<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLA2</accession>
    <name>A0A2G8RLA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLA2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLA2"/>
    <dbReference type="OrthoDB" id="2798231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="108" mass="12552" checksum="49BB44E8DE58354B" modified="2018-01-31" version="1">MNNIFKDLIILGKVTIYLDDILIFTNDIEEHRTLVREVLKRLAERDLFCKPEKCEFEQPKVEYLGVLVSENRVEMDPVKVKGIAAWPVPQNASDVRKFRGFIHQALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLM6</accession>
    <name>A0A2G8RLM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15112</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLM6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLM6"/>
    <dbReference type="OrthoDB" id="3219854at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="630" mass="70083" checksum="C4D6E2E28A0A8A4A" modified="2018-01-31" version="1">MFLIQQAQKLTTDPQNGLFSAVLTAFNVQSYALLQQDNTDLLAKALIQVSAQLSNFTLSGTTILSSASTFVQPSFSVPVSAVWINALWFASLICTLSASSVAIMVKQWLHQYDLGLSGNSHEVARVRQYRYESLVKWRVVEIVAFLPIIPQVSLLLFLAGLLILLWTLHALIAGIATVLIGGLVVFTVATTLLPAIKPDCFYQSQLALGFFLALQALCTFFRKTKVGPSTFRNWHAREKSEVQIKRSDLDRQLAATTYGISLDDHVLNEVVLPCMWDLPSGHLSPMLDDVFRIANRWEPLVPCALHFTLIAARDPGPNAKAVRKLLSSTWWPRMDPASELGELFVRAMATLVSRGVEADYAFYRVSRTLSYLTSNSGSRVKQEVVEHLVSIYPNPKTGKQFATLVRNKDPEGMPIVYSYLLTLPTLVRYLARLVVDSPHETERIQLHIDAMFHTLQSFLMHIAWTQDLSNLSIALWALARSRHVAQMVALKTDAYCSPLVPRDIVETYQDVLSNIDSSVTTKAFQMYFKRHLDRLTTANLGTKEPAELVTMLQDDVDVLAKLFQINLSHLSGSPDVRGIHNSEITPPKSPTYNLQRFISEAKNENKATGSPQLATDNGGFSVILACYGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLM8</accession>
    <name>A0A2G8RLM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_15098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLM8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLM8"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="480"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="351"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="585" mass="59833" checksum="5A868A54F1167EA8" modified="2018-01-31" version="1">MQHRKRRVEALAERAPALINLPIPLPSIPLLDPILTPLIDGSSPASSTTTPSTPTTPASQPTTATQGASPSQTPSTATQPSNPQSPTTSPNASPTTGDGSGDGNGSTSGNGSNPDPSGSNPSSPSEPNPAGSTPSSGPSPSDGSSSVSGISFRPGGAVITISKDGQAFLSSSQSGSAGQETGGNASPNGATQASIPGYSGSASVTVTGSPTGATTGSTNINADPENPAQSGSTHHGLSGGVLAAIITVSVLLAFVLLLCCMRRRAIAARVRRRREWFAGGETEDTGYADRDSASTRSSFATHYDHGSVESTLPAYDVPSMQAPQTMQQIWPSDLSGSIVAVPAVSHAVESSSSPTIRVAADRSSIHSASSSPSRPSSQVPLPRLVVPPPAAEASSNLSPLSVRPYSPTESWWFPKPPKDDAIVGVASLIRTSSVTSSIQSHDTSFHAANPQNTLVAAENPFAEPEDPFADPATAAWPESPTVPSFPAIETVRHAFMPSMPDEMAISVGDRVRVIHGFDDGWATVQNVGTGAQGLVPLDRMRDDGKEGTAPAFLAKKRISSYVRPRDSAQTRASFLSGVSTIGAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNQ6</accession>
    <name>A0A2G8RNQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNQ6"/>
    <dbReference type="OrthoDB" id="2758541at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60248" checksum="4BCD2DF2040E4C2D" modified="2018-01-31" version="1">MDPEEFLDQALFDSYESLTHAMTVCHKWYVVASEKASLWTDIDYARGPAGPTCLLERSGTAPIHLRVILERELEDMAPFPELVRTHAFRLRRLDLYMTSANALHTAELLLGNDMPVLRALNLSDDYYRKNAILRNAPGRFPSLRGMMLMGFLWLPPPEVTPFTALTHLHISMLAETPLATITAFLATTPALEVLELHECETVTLAELPAGTTALAHLTHLAIRRMSTRAAEVLMPALLLPAATAVHLWLDVDADAPPSDALLPHPAYWRDATRLRAEEGSYGGISIELELEGPSSPSLPHPHPHPHPQRQRVSLCLEYTAADDWDGHPLWPLPVPSLATLPSVAAAHLSLFGGWRAALPRFVARLPALAALAVEGCMADPACAAEMVSALRDALWYHNPNRDRDRDRDRDRDRDREGANEDSGRGLPRLRELALVLPCAVPGLTKSLTPALRKRKRDGLQLERLRTWIAPERRDASAATEGEAGEAAAAAAAAHAARGRDLGDALAEYVGAGKVEHEDGPFWPRDEEVWRRENEFWEVPRTWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP44</accession>
    <name>A0A2G8RP44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP44"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20433" checksum="4F1D124CF04F7F02" modified="2018-01-31" version="1">MKHLSRARSHLGEAYKDECQGTKLSRSTSDFYPCIRRVVTSTAHTMQLFAIVASALTLASAVVAVPAGLAARGASTVQVTWDSVYDNPSNSLDIVSCSNGANGLEPKFKTFGDLPDFPYIGGAQAIAGWNSPNCGSCWQLTYNKTTINVLAIDHAGSGFNIAKEAMNKLTDGQADALGVVQVTSQQVDASVCGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPF3</accession>
    <name>A0A2G8RPF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPF3"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="45"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="303" mass="33762" checksum="9AC0E6015282A58A" modified="2018-01-31" version="1">MVSTTRADGITWLPPEWADWSFPDPEVITDELKKEFTDEQRAKAWDDASGAVKTYHNELVEQWQKAMDSLLVYAGLFSAVLTAFNVQSYQLLQPGPTDPTLAVLQQISSQLNSFTVNPSFINSTQPARSPDQLLPPFQADVSVIWINTLWFVSLVCSLASASIALIVKQWLFEESKGLSGTSRETARLRQYRLNSLIKWHVGVIVLVPSVLLQVALFLFLAGLLILLWTIHVTVAAVVTVFIGALFVFVLVITILPVFKLDCCYRSPQAYGIFVLSRLIWTAPPRVYTGVAQISCIHLPLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPQ1</accession>
    <name>A0A2G8RPQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPQ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPQ1"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="2"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="296" mass="32338" checksum="838288A4041E9927" modified="2018-01-31" version="1">MAGASGVLGSAVYAAFKSAGNVTLGLANSRSTDELTKLDVLDAEATERIFTEFKPDWVIHCAAERRPDVAEKDPEAARKINVSVPEALANLSKKLKFKLVYISTDYVFDGTSPPYAPSAVTNPLNLYGITKRDGETAVLGVSGSQSIVLRVPVLYGPAPVNKDSAVNILLDVVADQSGKQYNMDHFATRFPTNVIDIADFLVRLTTLPPSRAIPPILHYSAAEPFTKYEMCLIFAKILGVPHGHIIADAEPPKGGTPRPQNTQLYVHETEDLMEGFGSLGWNPFEEWWTEYLTKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ84</accession>
    <name>A0A2G8RQ84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ84"/>
    <dbReference type="OrthoDB" id="3360976at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="167" mass="18695" checksum="EF3C395046C82DA8" modified="2018-01-31" version="1">MLQLTFTDRPLNSIVVNAANGQIMYDVKTPQLRGGSTTTVRDARGNVVAKYESSAFVHELTIRGERRDLNGWLEREHTLSLSRRMHAPNGRKYEWRWHKFAWMVTDSETGQLVAMSRSASKLHGTKFTVEILEEGLPILDAIVTSFALLEARAKAAQAVALAREASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQA8</accession>
    <name>A0A2G8RQA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_13449</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQA8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQA8"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="214"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="410"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL23700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="608" mass="68748" checksum="7755CC9C263ADC4B" modified="2018-01-31" version="1">MSEPAYKRARIQPSPSPVYKLDDEDDSYEPYVPVAQRRQAKLAKLTSWGANAEKEKARRLQEEQDDRDDEEREEERRREKARKERTLLMEAQEVHDRKAAEDAKKTAAEKAEEVDAEILAAIAARRKLASDLELAKGVQYTEPMKSSWRPPKFVRDRSLEENRRIREKYHIIVEGEDLPPPIDNFTDMKVPDPLVKFLRSKRITKPTPIQLQGIPTAFAGRDMIGIAFTGSGKTLAFCLPLIMVALEEEARLPFVRGEGPVGVILCPSRELATQTYENVLTWTAALAKEERYPQLNTLLCIGGISMGEQSHVLNKGLHIVVATPGRLIDMLEKKRFTFDNCKYLCMDEADRMIDLGFEDDVRNIMSFFKRQRQTLLFSATMPRKIQDFAQQSLVKPVLVNVGRAGAANLDVLQVVEYVKQEAKMVYLLECLQKTPPPVIIFSENKNEVDDIQEYLLLKGVEAVAIHGSKTQEERQYAIKSFKSGAKDVMVASGVASKGLDFNDIQHVIIFSMPKEIEDYVHQIGRTGRSGKTGIATTFVNMNTPEQTLLDLKYLLMEAGQKVPPFLQSIEDPRAAQGGTLKGCPTTEEAIESLSYSSDRFYNDCHFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRG2</accession>
    <name>A0A2G8RRG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRG2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRG2"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF47">
        <property type="entry name" value="ACTIN-HISTIDINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="315" mass="35074" checksum="463208F03402063B" modified="2018-01-31" version="1">MNDLEKRRWDHLLSWLKIEHGMDVGEHGFHVEARDVTGAGRGLFASRDCPPGTTLFKVPSTALMNRTTLAKLYPRLRKLSATQLISLHLLLHKPSGDDDSLDPAFGPYISTLPREFSSHPLTWMVKQKLRQETEWERGTLVLLPPGSARKCAELHTRFWKDWKALLPVLDETAHSQSSRPDLSSASFGIENNAALVLDYLWSWLNGLYFVISSLYRRLMDTPQSTRDAFSTVSGLTGLIQTTSLSVPYWTLPTTATAALIYSLSSTQRSGERWKKDRLSTSSSSDLLRVPSPGGKSYIFSTGTILTASCSLSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRL2</accession>
    <name>A0A2G8RRL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trafficking protein particle complex subunit 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRL2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRL2"/>
    <dbReference type="OrthoDB" id="10256906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055505">
        <property type="entry name" value="DUF7077"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045126">
        <property type="entry name" value="TRAPPC10/Trs130"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022233">
        <property type="entry name" value="TRAPPC10/Trs130_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056913">
        <property type="entry name" value="TRAPPC10/Trs130_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251">
        <property type="entry name" value="EPILEPSY HOLOPROSENCEPHALY CANDIDATE 1/TMEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13251:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23274">
        <property type="entry name" value="DUF7077"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12584">
        <property type="entry name" value="TRAPPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23036">
        <property type="entry name" value="TRAPPC10_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TRAPPC10/Trs130 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7077" evidence="6">
        <location>
            <begin position="721"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="TRAPPC10/Trs130 C-terminal" evidence="4">
        <location>
            <begin position="1000"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="123704" checksum="D614050A22D5BDF0" modified="2018-01-31" version="1">MSAQRVTVTYSGPIVFLSTDHWKQIQASLASQFPLRNLHWKSTSRNAVRSIQELDVKLVPFETLKEDQAASQVPQTVLEKPLLHLYIFTCEDSEVYRSTVRKQLKEWHASASTRKNQEWLIVHVMRPDQSVGQGRLFQIKTSVLDKVKADFNLDKKDRYVQLVWSAEKDNPTVWADFISKVKDGVLSSFDAALVQREEEMKRSEGQRTMPGWNFCTFFILKASRVESVASSLEGMNLHEDALQQYYELEYLFFQVLREKNLSWFGALITPMPTDDSVPLLSITKKPYRDLILANTISVFDFRVYLLARQCLLLSKMGDMEELCRKAASFLSIFSRTLREVENTLPPFFIESWIYSSSLSVVDQADEWAKKITLEKAAQSSFNAAKAELLELARHQRGRSPLIHDKLDILGIATGFLPNKPPFSLMLPSSFDLAAKDPKAKRGSMTITKTELLTSMEQQDTLYDLYVNVTNRAIELYANSGRRKFALKLHGSLAALDIHRGRLANALQTYTSLPAHYSPHGWTSMEAYMLNRALNIHDAAERAKDREWIHILLHFLRAYVEDGGRDLLLSEEDNKAYVEGLIAALKEAARNLDNDVPFPDHPALSVSLVDPHTRLAESRDGSLLTVAVHNKLPCDVPAEEVRLQLNGRDSSQFTFTAKVTGIISGRTELTLFCPSPAMGTFTLASTQISVSRLLFQWKHTKTPKQIKAGNMPKLVYIPKDARALDVKLKQPPLIELGTTSRIRVVLSTGRNEIATAAVKLGAPSGISFRCEEAELMGDDPPAIRFDAESLTFLDLKAGQTVVAAVPHSDASAYAYMRVNITVDYVTTAEPDIPRILRLSRVVATGLPVEINVQDFFRGTRPAFYRVHLVDKDTPACSSALGTVVVAGPDHGREARDGLKLQITYRMLREEVEALIELAVSEVSSKTPSLDSFRQDMIDKLVQALELEASWVELYGITGELVVPGITPTDDEVGSGLRQVMETLNQRRSAMSFGEWRDIVIPVDVPQIHILASARLQILENPFSSEMEAVEKRTRPLYAGQPISALLTVNTSFHWAPPEDVKVQRYNMRYDIEDLTQDWLVSGRKRGDFVAKVSFLPMALIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRQ3</accession>
    <name>A0A2G8RRQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcriptional coregulator SSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with transcription factor HSF1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRQ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRQ3"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000021">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="610"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="614"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL24182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="652" mass="70819" checksum="CE66B925BDB317D2" modified="2018-01-31" version="1">MTKAVGIDLGTTYSCVGVWQNDRVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPHNTVFDAKRLIGRKYSDAEVQSDIKHFPFTVFDKAGKPYIRVSYRGEDKEFSPEEISSMILVKMKEVAESYLGGTVTSAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKTTGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVTHFSQEFKRKHKKDLSGNPRALRRLRTACERAKRTLSSAAQTTIEIDSLFDGVDFYTSLTRARFEELCQDLFRSTLEPVEKVLRDAKIDKAQVHEIVLVGGSTRIPRIVKLVSDFFNGKEPNKSINPDEAVAYGAAVQAAILTGDTSEKTQDLLLLDVAPLSLGIETAGGVMTPLIKRNTTVPTKKAEIFSTYSDNQPGVLIQVYEGERARTKDNNLLGKFELSGIPPAPRGVPQIEVTFDMDANGILNVSAADKTTGKSNRITITNDKGRLSKEEIERMVSEAEKYKAEDAAATERISAKNGLESYAYNLRNSLTDEKLADKFDPADKTKLETAVNDTISWLDSSQEASKEEYEEHQKELEAVANPIMQKLYQSAGGQPGGFPGGAPGGFPGGAPGGFPGGAAGGEEGPSVEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRV2</accession>
    <name>A0A2G8RRV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13998</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRV2"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="12">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL24245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="128" mass="14108" checksum="9248DC32C34E095F" modified="2018-01-31" version="1">MADTDAKAKAWPRAPPELNNDILDLVERASQFKQLKKGANEATKTLNRGIAELIILTADTEPLEILLHLPLLCEEKNVPYVFVESKAALGRACGVTRPVISASITTNENKELSSQIDTIKLKVERLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRX3</accession>
    <name>A0A2G8RRX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_14013</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRX3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRX3"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL24260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="509" mass="57366" checksum="E68DC0094FFE3E8A" modified="2018-01-31" version="1">MASSAPPPATSSSSKPTGDSLFPKPQPPQSGVRAALQYTGIPPSWLDKRPSLPSRNWLIFLGVTSAVAGYYIYDRRECKKIRQEYVDKVKDLATVPMGSMELPRKVTVYGAKWLGDEDYDRSMKYFRKYVKPIIVAAAVDYDMVKGRRLGDIARNVADEIRADRRIMLGLDQPFVGPMQLPGSTPAEKRQRKVDGGIVIVGRHTLKEYFTGLKRGWTEGLEPVDREERLAQMLEADGKFDEPDPEPSHDVILGNDEPIPTRSRLPTSNPAFSVLATQSLRAPLPPPSKDAIPSHLNAPPAAIPPQPPMLLVSFTNHIGFTQIPLMIWEFFNERVKVREGAEAAYKLVLGNTRPFTAPLAEALSPSEVDFDPDQPQKPSLGELSPKDLDFDREAESYYKKSVVRDFLSEIEKTRKEYYNSLVKKLETARALAQRTREPTKEETNYPPPTEVELRAERLKKEQRWTTDEEGFSIIRPDKDVEWDERFRTVLRVYTDPSPEQSTSTDAPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRY3</accession>
    <name>A0A2G8RRY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRY3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRY3"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="306" mass="36471" checksum="0EDDFF5D0A5DB727" modified="2018-01-31" version="1">MARRLYLGKLPPDARADDVSKFFDGCGRIVDCRVMTGFGFVEFESSRDAEDALQHFNGKTFMGANIVVEFAKETRPRRDPYEADRLVRARRPPGFRLIVSGISRDTSWQDLKDFGREAGSVSYADIDRDVPGEGILEYLSREDAERAVKELDGRDLRGQPVRVNLDRERGGADDYRREPRRDDRRDDRYARDDRYARDDRHRERDDRYRDDRGGYRRERSRSPPRRAEAEDRRPRSPPPRREHEEKRPAGYDDRRGGYDDRRGPDPYYDRRRDDLDRRRDDRRRDEREDRYEDRPRHANGDNGWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRY6</accession>
    <name>A0A2G8RRY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Nuclear proteasome inhibitor UBLCP1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_14028</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRY6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRY6"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090364">
        <property type="term" value="P:regulation of proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01813">
        <property type="entry name" value="Ubl_UBLCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011943">
        <property type="entry name" value="HAD-SF_hydro_IIID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051658">
        <property type="entry name" value="UBLCP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02245">
        <property type="entry name" value="HAD_IIID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48493:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING CTD PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="14">
        <location>
            <begin position="170"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL24275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="363" mass="41040" checksum="4C9D12CC320DBB6F" modified="2018-01-31" version="1">MSSEASTQPGGQMPMASATTVTAQDNSPETEQNERWIQLQFTWSGKPFTMDIAESDRVFDLKAALMSLTNVPPERQKILGLVKGKLPDDDAIIGDLKLVSGKKFTLVGTPQGHEIKDPHELEFLPDVINDLDVDFSADPAAAATYMNDQRNRRKVKEHTQKLKVDIINPLREGKRLLVLDIDYTILDTKPLTSGALPPRECARPGLHEFLEAVYPYYDICIWSQTSWIWLETKLVELGMLGGVRNYRISFVLDKTCMFTVFSVKDGKPYKHSVKALQIIWNHFPQYSEVNTIHIDDLGRNFALNPKEGLKISAFKNAHTQVGMADRELNKVARYLVHIATSHEDFREANHAKWKDTVKSLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRZ0</accession>
    <name>A0A2G8RRZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRZ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRZ0"/>
    <dbReference type="OrthoDB" id="3267661at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="163" mass="18446" checksum="A502C60C839424E7" modified="2018-01-31" version="1">MVAAVASPTVVPRSPVFPRLLPLPPHPHPIPPAPSFQRRERFINYRDIWREMEELSEEEDAVEDQNLDIKTRGYNFLVPIGRTWTQHEEKNDADDPSEGTDGSDRTGEANSMMDDDENESSEEEEEDLDADMEDMDRTADTTADLDEMASSEQSSEADDSEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSR9</accession>
    <name>A0A2G8RSR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSR9"/>
    <dbReference type="OrthoDB" id="2744747at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="159" mass="17797" checksum="6D952E0AF12157D1" modified="2018-01-31" version="1">MESSPAVKVSIAAQDSVIPSLPAQPFFFPSDRQFPLYAHCNSQRPVRRVNRHRSNGARRTPSRRNDLRTVDNRLPPLKQRRSSFALSAAFERDGRVEFVVSSKLPPTPRSGSRSVTSVSTTSSVRSRMKAVLVDLVHTVKAKCHRNRSLPRILVVEPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTI8</accession>
    <name>A0A2G8RTI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTI8"/>
    <dbReference type="OrthoDB" id="2745177at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="675" mass="77056" checksum="33829952FC68BD38" modified="2018-01-31" version="1">MPPRKKAKIDHPQEGTTTSTGRTTRARSKAANAVTAADASDVQPPDVASAAPGAAKLQRGCLKDILNFAIEIQLMIFENLHPQDLFNLSRTAKIFHGFFLHHSNEVLWEAALKNADDLPTRPPWMSIPSFIHLLYLTRCHNCGCPNIRKVVIWEWFARFCSKCLPSVTYDSPHVERRFSDSAGCTIYRDYVLHRIDAPTTAEPRDRSYERYVPYWNLPEKINWYLKRDVDELIAQWSALPQPVDSDAAKAIQTQYRKDFVDRRKHAAQCEGWYLRREEDRKDDLRNGRIDRFWDIVDKLKEEGWKKDLDFLGSKGLEKMSCFPVVRQSAKLTNKGWEKVQKTLRGFLTETRKARLQKEREDLIRHRFAELDAAIIAHCVTIPRDATMVCHPLALDFALSSDIEPLVNAPSSKDITCESFTAMIPKLVTGWEARQRKYLKFLLGQFITEVPASVDILDLAISVVYMGTRSGYDTVRTMRYPYLLARSPFRSIDPRDHGSFMSGHYAAPVVRDRGMGPFDLKKLDEKRVEVGIKWMRNIVTKLGLDADTATLADLERCEARVRCLKCAEEGENSGAYTWEAAFAHTAKHNTTRFESRNAYPRSSHNRWGRVNKADMPKVKEREAVAHALMVGSNCVWSCALHNIEDADGAITDGTIFWSPIDNTDFMKVKKPAVDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUE0</accession>
    <name>A0A2G8RUE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUE0"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="513" mass="55839" checksum="F24B1DD2E4529E77" modified="2018-01-31" version="1">MPPPSTSAAHEPSPPAVAANGVSRPPSSQPIVANGKAPESKVEPQYTIRFASKPSIPRTMDHNAPARDTRRTAIVQAICSRDDPKLVLDMIREIPPDLTALASDVDLVLDEQGHTALHIAASTGRHATVEALLNAGADIHRGNFSGETALMRACLATHCFDTQTFHTLVAALNVSVRTLDTARRSVFHHIVATAGVKGRAVAARYYLDQVNLWIVNRERADFRSIIDIQDEHGDTALNIAARVGNRSLVRVLLDAGANKLLANKLGLRPGDFGVETEELGGGSRSEDILSSLRSVPSVPIQKSQDVIADITTMIQGLGTDFGTEVKSKQDALDVTQVHLRAATRELSEQRRQIQHWQARCGELDQTTQRVRNLERALSDEDSFDWTGRTEPPPDGGPRGGQAGAVDMPMPANLDVDPTVPLGDSAATLVRLRRMKMWYARVEQLLETRMRSLQGASAEKEFQCKKIVALCTGVPIDKVEELLENLVVAMESEAQVIDISRVSGFMQKVRNGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUP0</accession>
    <name>A0A2G8RUP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13112</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUP0"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL25223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="450" mass="49425" checksum="D919B0A298DBFA0E" modified="2018-01-31" version="1">MSLVSALRAGRSAYGVYLSPSAVTPTLGFQTRGYAAPAKPTKKVASKFRPNAKNERKKRGPRDTGLFRPMSVNNLAHPVFQSDLRGTLQLPVFRPEALTAEAANTAMAFPTGDSKALKAYGLPTNVLVDYMLLSRPCSVVRESTVEVLDQLDKAAGSSSAQTRVVFTGKSGCGKSYLLVQAVQYAIQKDWITLYIPRGINLVNSSTPYVYDARTQTYGQPAFAQQLLRRFVDVNEKLIKDLRVQGSYPFKDATIGSSSSLLDLINIGLESQESAPAVLSVLFTELSKQKEFPVLLAIDDFQALYNLSTYRDPYFKMVKAYHLALPRTLLEFASGKQSFARGAVLGALSTQNTTFRPPLELTEALGLVPDVPSNPYVRREPELVGYAKGLRNFPVPDQLTIDEAASIFEVWQNSKAPHVARGDEVFLSKYTEAGGNAREFVKKSLLQTVTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVN1</accession>
    <name>A0A2G8RVN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVN1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVN1"/>
    <dbReference type="OrthoDB" id="10691925at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1049" mass="112902" checksum="AE13CD5ECAC71979" modified="2018-01-31" version="1">MGGVEMVPPSLSAEAGPSRLTTDTPRRVSFPDDLIHSSKAKKKGRKGKGRAVDEEEREGEDIQGQSRVRRPSGAASDPEAMDVDGQPPQEECLPPRLRKAWIAKSLERLRGQRDGGAISPALSNGEGESRMDESYFDSRDMPPPPVPPSRTPPILSTSLCPPPISATSSTSSTSSTSSKQRVATDGTASPSVPFSKLSLLSPVVPLSLNTPTSARPRSPSVAPTPSTSKPESKKRRRPTDSPQPPLADLIPAKSTKAKTIKGKEKAKDKERDAESEEEREEAKPKPKPKSKPKSKTTKETKLACPSTPATESDEPVLKSSIVRRGEKKTVARGKGKDKAKAREKDREKARSASAELSGARSTASASATASPCVPPTALAPLSSPGPPPTTPIIILPELPPEPPDQKRWSVAIKAPDNVVDEEGQAPDAMDVDRPPAATPKASPAVSVRALLTPPVASLDLPTLSTPSIPSPSPAASPLVPMAALPPSEPPTTRSPSPPPAPPAPPPPEPPAIELESLPQDAMVVDQQPPEVAPNPPPPTVQPVPDSDSHAAAPSSLLPPPEAEPRYDSEAPTDRHSSPAPQEPEREPEESKGPPAPAKVKLSLKDFALRKKKQREEQKVREKEVQEQEKEKESASASPCIPFMASPLLEPDTPAIAIAHNNATERLSPHPDGLGIVNGDMDGDVKMAEVEAGRDLEAHATITEDAKEPGEQEQLPAEAINGVHDERTLDAVDKMLPVEELPPPPMSPVVKETTSDFVAPVPNGHSTYSSTRRSPTPDRFFYGRRKTETAWDDRRHRSPSPDYSRRRRSPSFERRRRSPSEEFEDRREYRRGDSVQAKVELIDSFVPNGLVAPVRDLSPADPYGRASPVTPPRATSPSKMSYSPPPRNVLPPPQSQPQPQSQPQSSQEDGEIFSPPPPKAPPLAPRSHTPPTHPRSFYAARGDISPTRRSPPPSSVRRPLHPTQYSRTPGPGPPRLAPSAPRALREGIGYSPSLYGGGGQNAPYFAPRGPSADRDRDRDRGRDWGRERADGERTWIQGPSRGRGRGTWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVW9</accession>
    <name>A0A2G8RVW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVW9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="107" mass="12568" checksum="845C0C76C994FBB8" modified="2018-01-31" version="1">MHRKTQLPRPPTLPLPRRALVVQPPHDRDAALRVEQRAPRLRVAAPRARRAHHPRELVFRRVHERQRRPLVRPHLRVERHERGRAPGRRPEPQRGQRALRGRGGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVX1</accession>
    <name>A0A2G8RVX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVX1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="171" mass="17797" checksum="13F27B33F424B05D" modified="2018-01-31" version="1">MAPLAIRDDFPNPSSINPGVVFAIIAGVLIALAILITILRAASRARRTLPRRPPAPRVAPSGGNATDYLRPDRPGNRTTRTAGNNDTFSTAWKVEDNNIIMTTMNNNAAAAAAASASPPAVHVPHVHHDHPLPPLPASPPPSGPTDMGTSWGAPTAPDPPPAYSEPFSGSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW83</accession>
    <name>A0A2G8RW83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW83"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44767" checksum="1BAA534983B77CF0" modified="2018-01-31" version="1">MSERHCPSDSDSEPDVIFDPELPPPVDYSYILCGLDDPSAHPHWRRFEEYAAYVRSITGLFAFDGPRRLELWEDLGRCIAPAPLLPRLQAVSFRQDRTRRKFAAGTFYLLSDSVTSLEYGGREYHNPAIRSAILRAFCYAEEIQKIRIPMQPWEDMHTFGDHICHVEVIPEIESRALKYLAKIQHLRSLSLSLGAIDLADGMLTYPRLETLDLKGHWGDHTALLNITNAPNLHTLSLEVLQRGASAQMFAKYTSECLNAVSTRLPSLTSLAVRMNSSPPTPLVYSIGAFHRIVQSTFQTSLLDVVRPLLPLHALRAFTLILPNYIDMNCSSDDLLAVSEAWRDLEGLHIHLWDYFTLKGLINHPGAGERPRGWPFAAIAQLSALADAAPAPDGCDPSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWD1</accession>
    <name>A0A2G8RWD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWD1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWD1"/>
    <dbReference type="OrthoDB" id="3217871at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41762" checksum="BAAF859AC8A7D183" modified="2018-01-31" version="1">MDPYESIRQSIAIGKSMARIKRTSMKPTHTSPRRQHTGTRPHPLELKKDDEFWYDDGTIILISQNIEFRVYQGPLAQHSQVFRNMLAFPQPPIPGPSHASSSRTTLGSGLVAPCPTVHLTDSPADLRHFLRALVLGGTIQDPPPSLTFYAVCAWIRLGHKYEVDKLVENGLQYLRRFYPSTFTPDPEPPGIWAGPIRKDRPMDLQGRSAIAIVNLARLTDSNDLLPLALLECCKLGADIVKGYRREDGTVEFLQPDDLGRCFAAKGALELSVVNAYLRIFEHAPIDGSCDGGQSCVVAFHYLRYHFRVATCEDVGVDELLVEDRMESDLTNTLCSQCRCTVISDAVQGKRVLFWNSLPNRFELDVVGWGVDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWJ7</accession>
    <name>A0A2G8RWJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_11648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWJ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWJ7"/>
    <dbReference type="OrthoDB" id="4476201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="534" mass="56757" checksum="E4E91AB301DFE833" modified="2018-01-31" version="1">MSVEKQRAKTEIQRADEELLATLGYKQEFQRAFTGLETFGIAFSIIGLLPSIASVLADSLPNGGPSAMVWGWAVSSIFILFVGLSVAELASAAPTSGGLYFWAHTYSSPRWRNLLAWIVGYANTISSVSAIASIDWGCAVQIMAAASIGSGQTYSATRAQTFGVYCAVVLSHAIICCFATQVLARLQTVYVVLNILLCLAVIIALPAATPKELRNSASFALGGFENVSGWTNGFAFILSFLSPVWTICGFDSSVHISEEASNASTAVPWAIIYAISIAGVLGWAINVALAFCMGTDVGSILDSPIGQPMASIFFNSFGQNGTLAIWAVVVMVQYMMGSSAVLAASRQAFAFSRDGALPFSKWLYRMNGYTKTPVNTVWFVTILSIILALLAFAGPSAINAVFSLGVTALYVAFSIPIAARFLGDNSFVPGPFNLGRFSVPVAIIAVLWMSFISVVLLFPTSPGPVVADMNYTVVVLGGVLVLSVVWYYFPVYGGVHWFTGPIPTIDKDTQEGSGRSSTSGSMEKSPVTVSQQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXM6</accession>
    <name>A0A2G8RXM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXM6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXM6"/>
    <dbReference type="OrthoDB" id="2727692at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="303" mass="34292" checksum="DE7009B736D1812A" modified="2018-01-31" version="1">MSAVDAVLHEDCDRFVLFPIRYPRLWERYKIAQRSFWTTEEIDLSDDLADWTQVLTDDERHLLSAILAFFASADGIVGENLVQQFYSDVAAPEARCFYGFQLMMENVHAETYARLIQELVFDEDELHRLFDAVNTFPAVGGKALWCLKWFDRAAYPFPVRLIAFAVVEGVFFSSSFAAIFWIRSRGLLPGLCHSNEMIMRDEGQHVEFACELYSMLGDKVAPAVAHAMVREAVVLEQEFFRSALPSPLRGLNAPLMQQYIDINPFPFMSGSVIPGRANFFERPVSDYQGAPGPAAFVSRAAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXP5</accession>
    <name>A0A2G8RXP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXP5"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="61"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="366" mass="40794" checksum="276A0C4CB4059E7B" modified="2018-01-31" version="1">MSAHVSRKRSRAEDDGEGVPPAKRESEHHVKGTAGTGQTQTTASDGGQVFKKDREFWFDDGTVIFVARDTEFRVYKGVLASLSTVFKTLFADRGHTVRNVSIDEEQTILCPIVRLLDSPQDLRHLLRVCFFSKRLESLYEEKEPSYDEISAGIRLGEKYKIAEWYSQSLVYLKSYFPRTMNRWTALESCDGPPGWEFGNGIGVISLARKTEQLSILPAAFLSCMFAESDSPATLGIGHGFTTEDGSRQYLSPGDLTTCFHAKTSIRVAIVTSVFRTFEPEPSTGCKTSSTCKKVLREVLVGLGNNSELLLSCNPFSDYDSYFSGTTLAICRACTTMVKARSLKERQDVWNRLPELLGIDVPGWAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY30</accession>
    <name>A0A2G8RY30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY30"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY30"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="10053" checksum="7F25974E1C3EB225" modified="2018-01-31" version="1">MVLLVRLLQYPDKADFLTESERPWLVDTIERDSSELSRHFKRKFVFQALRDPHVWLLFCIHLCLIIPGYAFSLFLPTIITGIGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYN9</accession>
    <name>A0A2G8RYN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLM1/RGC1-like BAR-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYN9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYN9"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLM1/RGC1-like BAR-like" evidence="2">
        <location>
            <begin position="98"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="151" mass="17039" checksum="FF4D98A2349E808D" modified="2018-01-31" version="1">MNETVSISRTTSLSRQTSRRGSTVSRSQSLIKKNIAPHDLRPSDILIERFTAWKAIVKQLISYFEGIADIENNVAREMTKLAGVVQVPFRSGNQFLGEGGLQDIFYGIRDKTRAIADQHANLGRTVEGSIVQHLQKLRTEIKAHIKRKRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYR2</accession>
    <name>A0A2G8RYR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYR2"/>
    <dbReference type="OrthoDB" id="2140240at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013869950" description="Transporter" evidence="2">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="26048" checksum="C4A2A479466D61F2" modified="2018-01-31" version="1">MKFATAALAAAAIAASVRSLPLVRRDVDPALIPQFGVTAGVSPDGTGNCKGVNNINIPCACPPPRDQFVAQLNQNVNAGFVLNNPSVKVSFPTDASKASKLARLFVATVTLQNLHGPGVGCPQAATTFGAQQAAIEAGTDTPAAPAPPAAPAAPAAPAAPASSGGVDPALVPDFGVVAGTSPDGTGNCKGVNNSLNANVAAGHMVNNPSIGAPFPTGSSKADQQARISTLLSTLQNLHGPGVGCPAVSTVYGQLQQQINALPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZG7</accession>
    <name>A0A2G8RZG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RZG7"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1480" mass="166605" checksum="DB4939BB2E32DB9F" modified="2018-01-31" version="1">MKRSNEERTTQMEDEMKKLKDLLENHLGPAKTSYSQAEGALRKEKKHLEDFQFQYAERLDKMQASLGKAERDLSVLKSQWTSNKKILEDMANQLSPTQDLAREAIEQLRQVDEKQQTVWAVVRMLQDDLHDFTHRTPGEESNDVEAPGLLSLASELSGPRLEDQWPPSPNYVSSRVKDDERWDCPRSQSSLPSSQGDSAWSDSELSSALLLDCQEHGEAAVLQTHTNVSDTPQAQARSTEPPSVATAATIGQNFVSPAATSGLVISDLIVKFHSICNWWSAQALCKILEGVPLLPDCTSPLLLALLSAMLVTDHRPNCLSRASVVGMGVIPLNNVFIENDEEQSGRLLTEKIRKKHLEADKWRKEQEELRESTVSHTILLAAASQPLSRQGSISLPVRRRDTQDNSSFQENVTDAPTGGSTRASSASTPSTHNEGERTAQSSTPPSGAIAARERSLANLTSIVQRLRNRFPSGMGLTFSNEPSMDGPPPEPNEATFVEAYQWFLEQRRYIEEDLPPLSHYEMDRRRIGLLRTIEDPSKLAYAKSLQPFVLAALIMSIVLHSLAAVSRVHVDYVLATLQAVLYGTVLWCNAQSGDSSDLTPSQASWLKTVPGDTRTVLTSLGLEPDIIRYACCPQCFATYLPDPDKPDDPYPRSCTFQETNKPICGAELVYEQEHAPTHKGGKVKTTLEPLQVYPYRTVESYLTDLLSRPGYVKMMKTAWTRSSNPKWRDLFDAPGLRNFLGPDGRTPFSEQSDGCVHIVFSLFIDWFNPFGNKKAGKSHSVGAIYLVCNNLPPHLRYKPENICLVGIIPGPREPQLHQLNHLLRPLIDELLVLWHCGLLFAGASPLDPPLLIKAAMIPLVCDLPALRKTAGFAGHMSSHFCSFCELTKDRINDLNRLKWPRHSWDDHRRYARAWLDAPTEAARDVEFKKHGIRWSELLRLEYWDPTRFAVVDAMHNLFLGELRHHCRDVWGLDVKDKTGDSKGADPHTPEQQRVQLQRVITGLHKHSKNALDKVRKGYVVAVAEFNGVAPEAGEFTKAAYVAALISWAKDFTGSIKLPPVLEESTADFHLVEGPHDISKFRVLDQHTLDQIRKDIAATSFPSWMERPPKNFGSPSHGKLKADQWRTVCTVSLVISLCRLWGSSTASRRQRLLLDNFLDLARAVDLAARHAMDQPRVEKYDGYMLSYLTSLRSLFGHQLVPNHHLSLHLRECLSLFGPVHAWWAFPFERFNGLLGRLNTNSKSAQMAVTFMRYFYIGVNLRWLMNTTKWPDMSHYQHMVAAYKDAVMNAVSIRGVNVADIVAFESHETDTDAYMAIYDEQKEVNLSADVHRALATLLRPSGDKQALSAKCHHIRSVDRDGMTFATRKAGKRNSFVLFSSDHSDTWASSFPRAGQIADIFIHARREAERIVFEPFFVIDEYMQLGRAHATQDPYRSYADLETCLHYNKFHPTQRVVRLSNIQCHFASLVCTVEGINEECIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0N8</accession>
    <name>A0A2G8S0N8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0N8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0N8"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="81"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="236" mass="26380" checksum="CCBF55045BEF5E8F" modified="2018-01-31" version="1">MTLLPGSLRSQYYEVDPYKKPAELLELSPKGLVPALKLHNYSPPKALNESTVIIDFLEELALSDARRSSPTTESLFPPASDPYARALVRLQADAVNRNVVPAFYRYLQAQEEDKQVDGAKGFVDAILGVVALFKRAEDEGYTTYGLWNAAGSLSYADVMIAPWILRATNVLKHYRGFIWPDNEALQTYVQKVLANPAVKRTCSTEELYLDSYERYAFNRPNTSQVANAINAGRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S184</accession>
    <name>A0A2G8S184_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 12 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S184"/>
    <dbReference type="STRING" id="1077348.A0A2G8S184"/>
    <dbReference type="OrthoDB" id="95118at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013560405" description="Glycoside hydrolase family 12 protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="26865" checksum="6F29338D8C7837F4" modified="2018-01-31" version="1">MFSKAFAFLALSAPLLASAAPAEFAKRQLDTSSHCGQWDVVTAGQYSLLLDQWGKDGATSGSQCANVVSLSGNTISWKTTWTWTGGTGVKSFTNIQLNQGINKQLSAISSMPSTWTWSQSTSGSIVADVAYDLFTSNSAGGSNVNEIMIWLANFNAGPISSQYGSDGQPVPVASSISLAGHTWNMYSGSNGANAVFSFLPTSGTITSFSGDIKTFLNYLVQHEGVSSSQFLVTAQAGTEPTSGSATLTTSAYSLVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1D0</accession>
    <name>A0A2G8S1D0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1D0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1D0"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32566" checksum="97FA545FF7B67921" modified="2018-01-31" version="1">MTVSTADTVPAALHYFSPPADGSKPYIHINADASTGQRQRNWTTVAHDTEIENIRGKEHTVSLDTTGFQFFKGAVPHTTFENDEVIEKEYYPQSIDLVKQITGASQIVVFDHTIRRHRPGEVEDTPQKRQPVPQVHIDQTKDSSIARVHRHLPAEDVPALLSKRFQIINLWRPIHHVALDYPLALCDYRTVDRAHDLVATTLRYPVRDGETFNGETFSVKYNPANRWKYVRGMEPDEFVLIKCFDSQDDGKTAIFTPHTAFEDSTTPKDAPLRESIELRLLVFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S246</accession>
    <name>A0A2G8S246_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S246"/>
    <dbReference type="OrthoDB" id="3350812at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="225" mass="25540" checksum="8FFAA30AE25D429F" modified="2018-01-31" version="1">MATTDLPAIEDILPGVGDLYLYQINRYLQFASLTCCVLEIISTLPDEVSLVWPAKRSFMKTIFLINKYSPLLDFTFIVLVDMVAREPRFCAVSFQALTYCYLVGTLVSEFILIMRTHALWAFDRLLLYSTVSISSMMVPHAIYVLYDMLRSNQFHTRQMITRTVGCMPNIEDSGAWPAYTYLICSETMVVILTVLKRYVDPTSIEGSFSSVILPTMDMLLGSGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S280</accession>
    <name>A0A2G8S280_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_10820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S280"/>
    <dbReference type="STRING" id="1077348.A0A2G8S280"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="54"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL27668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="363" mass="39895" checksum="0E2E5489E65FEFE0" modified="2018-01-31" version="1">MASGSGIALKTFNLANDIKDLNAQDEIFKFDPVENRRINNERPWARDPRYFQVCKISAVALIKMAIHARSGVPYEIMGIMQGKVVGRSLVVIDSFALPVQGTETRVNAQNEANEYMVQYVQGSEQVSRLENAIGWYHSHPGYGCWLSGIDVNTQMQNQKFQDPFVAVVIDPNRTISAGKVDIGAFRTYPENYTPADSGSSEYQSIPLNKIEDFGVHANQYYPLEVQIFKSSLDSELLGLLWNKYWVNTLSQSALISNRAYAANQLSDLHQKLTKAQTSLPSTRPPAPILIDEKAVIKQKPQDKNQESALSKAVKDSDKIASEAQHGLIAQVLKDIIFSSRLGAGSGAAAASVGDIVDTAMSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S285</accession>
    <name>A0A2G8S285_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S285"/>
    <dbReference type="STRING" id="1077348.A0A2G8S285"/>
    <dbReference type="OrthoDB" id="3266934at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="374" mass="38805" checksum="4EA45EBA5242946C" modified="2018-01-31" version="1">MVSPLSDPDEPMTTVTIPFGLSSPPSVIALSSFAESILPPTSASSQSPAPTLTPIRSFAWSNIPPTFDTCTSATFRWGYSGTSDLLEFILVPQMPPPTNSAIGSKRTISDGTTIAAHVDPTTLAWTWPKVNASAGEYVLQASGSWFNAASSSFAINDGADTSCLAAIVTSTTSTTPFPRPSNLPTTSVRSPANTGTIAGGAVAGAAALIMAILGYRTWARRRRQQLPHSHNPTEAAHRDAPSLYVASGTPSPAPPFSEKNAGGTNSLNHIATLDSLLSPNRRPPSFLLSDPCTPVPPYPSHTAALGQGMGSIMDVSTIGSRSSAAVSDATSTAGLMRTLSSCPPSYATRPSAPPSYTTNKTHSTMTQFSYASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2G5</accession>
    <name>A0A2G8S2G5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_10891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2G5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2G5"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573933" description="FAD dependent oxidoreductase domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>D-serine</name>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL27738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="373" mass="40403" checksum="3EA0CC83147F2AC7" modified="2018-01-31" version="1">MASSNALKKVVVIGAGVVGLTTAVKIQEKGGYNVTIIAETFPGDPKTIKYTSLWAGAHHVSHAANDAKQMAIDRETFDVMWELSAPGGPAEHCFLRVSQTDYLLDGRDECLDWMPDFKKLPEDSLVHGATAGSSFTTVNIDTPVYLPYLLARFLSRGGTIVRGSVQHISQVVEGGSNLFRHGRADPEPVDAVIVCPGLGARTLGGVEDKDVYPVRGQVAIVRAPWIRSGRTLSHLEQGLWTYVIPRRSGDVILGGTKQDNDWYPAARPETTTDIIERCLALFPEIVPPAIRSEREGTVEDVRALIVEEGCGFRPQRKGGIRLDVEWIPGREGQAKVPMVFNYGHGGGGYQSSWGSASIALELLEKALATASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2V1</accession>
    <name>A0A2G8S2V1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2V1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2V1"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL28099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="248" mass="27882" checksum="B2574635311012A2" modified="2018-01-31" version="1">MAPGTGKTKHTSRKCNTCYVSGDEKQLFTCSRCRSQAYCSKECQKADWKNHKSICQNNGLLETRLKEHETTLSGFMDRMVLVDGISMYELDQRLEKWVRFHNSTLMAATIQALRLPADLSRARTHLLYVALEPRGEDEHAGQAGKFFRVHDAYVVPVDDALRRPAPWPESIAQLHGMADEMERGGHGTVAAAMIECPPLAVQTVPFGSMTVRSLRSEMLGDSWKSFFMNHVEQGVRPKMIRSRPGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S303</accession>
    <name>A0A2G8S303_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S303"/>
    <dbReference type="OrthoDB" id="10508033at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="51278" checksum="EFC948E8230D7CCB" modified="2018-01-31" version="1">MTTHEIHRPIEDDEQVMEILDLTVNLNSLELSLDSSYLAVQRVSSAFSTLEVLQHLSLSEPLLPADRSWVPHALRALRAPLISLRITTSRYLSHSTPSALAIHFDRNVSHFATSSTLTSLHLTRIPMYDGTFLGLPRFPSVRSLTVDQRLPREPKMDALLHLFPSLDRWLHLRVEHWKALDIASNPQELAAIQAANTRAQEAFRWTKLDKLDCESSTALMLALRCPVRHLTIDCFDIPAIVRVQPRHVVIDSIRLPLHCDISHPLAATPEPVSTTHVVLIMVCNAQEYRNAKSNLYQTDNIRWDTVVRHATYPLSAFSHATHARLVLHCSTGCTSDVNEEVEDLIRNSHDAATSAGRPPHPGILAACSALRFFILTVDVRDETKSDPTLQRWVGTRAWRVTNEREGQGLTERPGGGDAPSKFEELNEYEATMIMEDEDMSLPEGWEERPPSCFWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3B4</accession>
    <name>A0A2G8S3B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3B4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="560" mass="60616" checksum="AB4D68D5340C8792" modified="2018-01-31" version="1">MFPIVSEPQPEAWDTYYSTLIFGGQDTYTAALWPCIVLMILSSVLLGLFTALASFAALVLVRKGLRHLSNAVLFAVILFMYASAVLHWTTLLLNVIGYYNIARAYAAQLLCQCTNGDTCRVLCPVILPQSTSPCTMISFGLPGAVHGLTVVLGDAVVWWRVWVIWPRSLIVRITCVVLLAATLVMGIIDTLDSCSAAAFSVLSVFNITNVPLGSFYQSDLFGLAASVLSLATNMVATILIGCKAWEHAKIMGSVSSLKRSSRVEKILIFLVESGTVYCIIWVGVLAHQVALLGTGLIGPSEQKVLDSFDYFIKGCLIPLIGMYPTAIITLVALNKSHFHGTSFGGGGPVSSISFRNPISTTSATGKEEHSLPMVASWSRSSDASFRTHDRLARAAGHADRLVDDLSLASYDSPSSSDERVIMHGLGRCLLLLVEAARRATAFDTYKIKITNRTAEANANVAEKVVLTLPLGERADIVPLPLGKNPRTYEAIYSALSRDVVGGMAQDPNTERVLRRQEARYRGPERGSLDVEASEHVRSLLIALSTFASLGLENPERKATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3H3</accession>
    <name>A0A2G8S3H3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3H3"/>
    <dbReference type="OrthoDB" id="2750120at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8513" checksum="B5160116867B34A3" modified="2018-01-31" version="1">MTSLGNILDELNTDVLLQVFDYLQPKGGLIPLSMTCWGVRNATIPIIFSRCRIKIKKPLNEDCFIPRSLWSYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S406</accession>
    <name>A0A2G8S406_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S406"/>
    <dbReference type="OrthoDB" id="10681136at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="207" mass="22192" checksum="720A77655DA413D4" modified="2018-01-31" version="1">MRPPVRYKDASPRRVSVVPRDDDDDDVLPPPIKPPEWDARSAAASSTAATFDSPISASERHFGPGAQVQVQSLDEKLRDIFYPAPAGPNPNPVRGSASFVPSFSSPTASTATTVTATPISPPPRAAHTQLPSFVPEPVTSPQAWTNPPPSPLPRYPSQTSEALSTFLSPWSAVGDRRVSVSPRTPVYGNGVLPEIRINGRPPSYSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S550</accession>
    <name>A0A2G8S550_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S550"/>
    <dbReference type="STRING" id="1077348.A0A2G8S550"/>
    <dbReference type="OrthoDB" id="2593747at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="261"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="468" mass="51148" checksum="A606894D906536C2" modified="2018-01-31" version="1">MEPISRLPSPWGPDSSPLPSPCPPPSPTYWTPYEGTPASRKDVTHARSLPLIPSQDRHPQLRTNTTFSPLPEHPDFLRGLQSHPMIIQRADPSWRAPSPTPSMEIVPLQKLDDHTSDPVPFPMSSGFTSPDLCPSPRPLPSLGSSRVGIRSLPTTTDSSPARTPDPAPGAFPALSSFAAPPPPPPLPNPAKNSGQVILKTPSPPTKKALPRPRLPALRRSTENPTATAPGNRPRSTESASSSSGSSAAGCPKHPQFYMQASMVVLKVEGTLYRVHKYLLEQHSDFFRGVLSDDADAMGHSDDRPLPLPENITRQAFDTLLSFMYTGIYDPASITLPDWVSLLRISTLLQFARVRACAIRQLSSRRAALAPVDAILLAREHDIPAWLGPSYAELVRRPAPLDDGEAERLGARVTARVGRAREVLRAEEYALYQQRRDGPGSKYTPSERPDEQLVARAVNEVFQLQPVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5J3</accession>
    <name>A0A2G8S5J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5J3"/>
    <dbReference type="OrthoDB" id="2765179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="187" mass="20604" checksum="5EC9BDC388451B40" modified="2018-01-31" version="1">MRDACHAASEKYRHCLCAGAVLSLTSTLQLDLQHESVRVPNGADVESNRTRVLSRASEHACPVTPEDLRAMARYLFEKRDDDPNTLRRYNFARWREFAARPENHKRTLDGWACIAPLSSKHAAGIERYLKEFQRDAEATRSTMGAKASSPGNYVLGGETSRESAADPEHAKDGANASGEGSVSVKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5L3</accession>
    <name>A0A2G8S5L3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09075</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5L3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5L3"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="395" mass="43402" checksum="D7691AD7A493115B" modified="2018-01-31" version="1">MPDIPVDAQIFDLAFHPQRPLVTTGLLTGYVTAFGYDEQGNYEEKFSIRPSKKSCRTLTMSEDGSNVWAAGKAKAIHVVDVGSGEIVETRAAAHEWVPLWDPRKQDAVRKYTHHFDFISDFLWLDDKKQLVATSGDGTLSVMDVRSKKMEPVAQSEDQEDELLSLLPIKGGQKIVVGTQLGILSVFNRKSGWGDCVDRIPGHPQSIDALCAIPSRYPNAQSTILTGSSDGLLRAVQLFPTKLLGVVADHGEFPIERMAVDMNGEGRWVGSVGHEEVLKLTDLQEVFEDDGDDNDNKSESDAAWDENANAEENGSGNESKAEAGPSKGEGKGKGEEASDAEDGDGDDVRDDSDDEEDAELELRKRKRKKEKDPLQTVKRQKGRNEVEAEPAFFADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5P3</accession>
    <name>A0A2G8S5P3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09105</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5P3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5P3"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="468"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="582" mass="63637" checksum="AA7CC69DE332FDE6" modified="2018-01-31" version="1">MSEIHGDGGPIPIIPDNLTIPQFILDVHHPARPVLKTPQPWCVDELSGREVGSDELRARTFGLANALKLRWNIGEDDVVCIFGPNHIDYPVAIWAVHRLGAIVSGANPAYTAEELEYQLGATKARVLISHAGSLPVALAAAQKAGIPNDRVVLFDGVPGANNVTLDTLVEEGLALPQAFVERRLAPGEGKKKLAFLSFSSGTTGRPKVKLSLTCRNAAHGAKSADIMAHYMGVKNQNRPKEIQRYLPGSKILALLPFYHIYGLVVVMHFHLFVGTTLVVVQKFNFEQMLNSIQRYRITHLCLVPPMIVLLCKHPAVKKYDLSSVRMLMSGAAPLSSELTNQLESFLPDCWIGQAYGMTETCTAVTFPPNDRRLGSLGSGGVLLPGCIARVVKPDGSLAGIGERGELIITGPSMALGYLNNKEATDETFLDGWVRTGDEVYFNERKEIFVVDRIKELIKVRGFQVPPAELEGHLLDHPDIGDVCVVGIPDEYSGELPLAFVVPSVSALTQLKEGREEGGVKDAIMKHVADHKVNYKHLVAVEFIEAIPKNPSGKLLRRFLRDRAKELQNTGKLVLPVRAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S635</accession>
    <name>A0A2G8S635_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_09285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S635"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1211"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1245"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1284"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1327"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1354"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1477"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="181"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="882"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="839"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL29236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1517" mass="168512" checksum="FE7A5B7FDDAA8563" modified="2018-01-31" version="1">MASTQAQPNSSQLEAMEGHDRVPELPTPSDIAASHGNSAHHNLVHPHSPSTDVDPASERHHVPLTRQLSSGSHVDIGHFDPQGVAQLRRSLSRQSHNGTELPFDLDPLREGQRQSANSISTEVTLASPDAPFDFGKTLRNVVKQLDEADIKRRELGVAFRDLRVVGVGSSASYQSTFGSSINPLNALRGIRDAIHPATRDILSGFEGVVRPGEMMLVLGRPGSGCSTLLKTLANERGEYHSVHGDVWYDALTSEDIEKRYRGDVQYCPEDDVHFPTLTVDQTLRFAAKTRAPRTRLNEESREQYITGVVEVVETVFGLRHVKDTLVGDASIRGVSGGEKKRVSISEALVARSLLNSWDNSTRGLDASTALEFVQALRLATDIARQSTIVAIYQAGEQLYEHFDKVCVIYEGRQVYMGPANRARQYFIDMGYEPANRQTTADFLVAVTDPNGRIVRQGYEQRVPRTAAEFADYFRKSEYAQLNASDVDAYRAEFVGKPERIAHYKSSVKLERARHTRSASPYIVSIPMQARALMLRRVQIIRGGIAAQVIQLASFVLQAIIIGTVFLRLNNTTATFFSKGGVLFFALLFAALSTMAEIPALFAQRPIVHRQSRAAMYHPFVEGLALTLVDVPITLVTQIVFALILYFLVGLRQEADRFFIFLLFAFSVTVTMKAWFRMIAAAFKSPAPATAIAGLSTLILVLYTGYTLPQPYMIGALRWITWLNPLRYGFEALIVNEFHGLESGCSNLVPQGPAYMNVSLANQVCTTVGAVPGSTTVLGDNYIAASFNYTYSHLWRNFGVVCVFCAGFISILLFLYEINQSLSGQSMVMLFKRGSKSDVVNGSQKEASSDEEKGHGSAAAAPKETGMHISEMKAATPEVHDTFSFHHLNYTVPVGGGDMRQLLDNVSGYAPPGKLTALMGESGAGKTTLLNVLAERTIGGVVTGSRYMNGHPLPSDFQAHTGYCQQMDTHLPMATVREALLFSAELRQSPEVPLEEKKAYVEKVLVMCGLSAYADAVVGSLGVEHRKRTTIAVELVAKPSLIFLDEPTSGLDSQSAWAITSFLRDLADSGQAIICTIHQPSAELFQVFDRLLLLRKGGQTVYFGDIGRRSATMIEYFERNGARKCTDTENPAEYILEAIGAGATATTEIDWYSAWCNSPEAEGVQVELERIHSEGRNKPPVQTRLATTYPTSWFYQLVLLLRRNAQAYWRDPVYIIAKLALNIAAALLIGFTFYKAKLTIQGTQNHLFAVFMSLIISVPLSNQLQVPFIDIRNIYEVRERHSRMYSWTALVTSQILIEIPWNILGSSLYFLCWFWTVGFPTSRAGFTYLVMGVFYPLYYTTVGQAVAAMAPNAQIAALLFSFLFSFVLTFNGIMQPFPLLGWWRWMYRVSPYTYLVEALLGYALGHQPITCSSVELVPITPPAGQTCEQYMGPYISQVGGYLADPSATDTCRFCQYQTTDEFLENSFNIFYAHHWRDLGIFIAFIAINVCFIYSFTYIFRVRKGDFLAAPFRRLRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S679</accession>
    <name>A0A2G8S679_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S679"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="213" mass="22961" checksum="9404614B9FD46117" modified="2018-01-31" version="1">MSSVATGADTQSLSFLPPSVFTLTDTIPLIQSSEPCALVLQPTSQLTPSLGHKRLLSALPCQQMTLSCPFRSIGIFETAHCETAPGLAIPATPDEFDFEDDEVANKTASSGDEFVVDGDEAEGGEDEDESEMEVDEDEPKRRGKGGGKKDPNPRKAVSLVLFVNARCTLCGRLVSRPSQATKTNKKKQKRKGALRSWTLLPGWEKIIQGPTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6D5</accession>
    <name>A0A2G8S6D5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6D5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6D5"/>
    <dbReference type="OrthoDB" id="3341476at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="116"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="412" mass="46788" checksum="6F07C0D6177D33F2" modified="2018-01-31" version="1">MQKHFGRRLAHFDVKIIYRPGRNQLAANALSRRPGHTDVPDCETLGPLFAHPLDSSAAAPATADSPRDLPVNNATGADPELPDEPAFPQGGLLWCCRHNGAGEVMVRVPTSLADARAVIRDVHQEISHLGVRAVSDALRTRVWISFPTEHVRDVVGRCNSCQFTRQEAPKPGPLHPLPRVDTFDCWAFDWIGPVHKSQRGNEYILTSIDHGTDLTFFVRSSHRTANRRQYSPTTARSSSHARSKPNYLHRLGIEHLHTTPYHPQTNGRLEKLNDNFVQTLARYVAPDRQDEWDNYVPDALLAHRAHHQRLEHVQNLERFRAEANAKGLQRLEKEASKRENAYHDRALGIGDLVLHRSENPTKLHPRWDGPFIIQDLTDRNTYQLRTRNGYVLRTLYNGERLPLVLLRQVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6L6</accession>
    <name>A0A2G8S6L6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_15684</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6L6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6L6"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL29426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="500" mass="56547" checksum="1FE42B87F81EB169" modified="2018-01-31" version="1">METHLSPWVLSLVVYLFLSLANRIRRGSGRRLSGPARLPLFGNALQLPRKRVWMKLADLAKTYGPIYSLQIFRTPVIVINSVEVARELMEAKSANYITRPLTKMVELSGYDNGPVLEPDAGRLRFQRKLLHAALGQGQVQQYEDAQEYHVQTFLRNLAQDPEHYFRHIRHLAAGITIEVSHGYRVRSRDDEFVKEADIFGENFSDAAMPNNYIVDMLPFLAVLPSFLPGMGFKRKAESYKKQYYALADRGHRWVQNEIAKGAARPSLTQIAIAEWKPGQYSEEIIMFSATQVYTGGGDTTTVILAAFLSFMVKHPEILKKAQAEVDRVVGSERLPTVADRPNLPYVEAVFAEVFRLKAPISLLPRLVDQDDVYNGCPIEKGTMVFVNVWGMLHDEDKYPDPHTFKPERWLGGERHPNVYPLDIAFGFGRRVCPGRHIGEDFLFTAVARTIALFNIAPGDESSGGVLVSELGKTFSGRPRQRFSITPRVPNVEELVRYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6U6</accession>
    <name>A0A2G8S6U6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6U6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="200" mass="22018" checksum="20F457DFB0F2CB8C" modified="2018-01-31" version="1">MSACARFRSVPPPDPVTGTPLGIDLRVFSRLGSLWLALPYALSACRELPDIVAALLQTWAPTKESASVPRKLTLTPSYESDFTRAEFAEVLRALGPVIEDVLGVQSESANEGNGEGGERADVTVKEAERGASAEVEVEVCVVDKADMREWWRGEARASFVRLGARGRLDVTFEKGFWPEAQWLDDSYEQEDEEALSARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6Z2</accession>
    <name>A0A2G8S6Z2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6Z2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="477" mass="53368" checksum="E375A7E8A60B1FE8" modified="2018-01-31" version="1">MTHADVDTLLATLHPHISFHRVSDGMPPPGYLRPRKDTAAGVRKLSQAFATLFGYHPGCDVAAVALQTPQSNETSKLSISLSPSIPPGFEENAKEWLARFAALRKESRTESESIRVPGGVREGGDAFSPAEKSLILHTHRVCYPAMRRRALTQGFGDWDVFVQGNWQDVATYGDDPTLAQGEHADNTQKFSELVRRFADCVRNSGDSDSLGGDEDVLEFHKLCMAIRDMMSNRGFSAFLNGHICQKPALTYFSPPLALHTLLALSQDPKLALSDQWSCTVLCPPEAVRPFNAVVTKTALSERFGEVHRIRWKLVEQAFEIFVSGIPNWYSTGANYHWNSDTKSLSTTRPVVVHPEVALIQHLLENGVEFEGKVEAFIACSRLPCYASIVYAGMVNQTLKTRFTMDIDDRRCHQLYKAEPWILPEDARPDVVANMKEHLLEDLRMRVSAWVGHRWSDGYIASGLGPDLDWEDSESEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7A8</accession>
    <name>A0A2G8S7A8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_08251</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7A8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7A8"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013546742" description="Exonuclease domain-containing protein" evidence="7">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="52"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL29614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="27902" checksum="8DF45FB853363F9C" modified="2018-01-31" version="1">MALHPLHGSCLFQLPLLALGMASPSNTPVYPTPPPPHPDATPRPPRFFSPDRYVAAQAQIVYYGIVSRLPMVARVTLTDYRGRILLDSFVRPTQPVCDYRTAETGLEAHHLADGTSLSALVTSAARSPVFIDVQRQVASLIRDKILVGYGLWEFLSVMGLAHPAINTRDTALFMSFRRTLGYRPNDVVPLATLVKQFMGRDIEQNGNIPVERARAALDLFRSCEHIWEEIISTGAWPCSLPPFEFRRCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7V9</accession>
    <name>A0A2G8S7V9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7V9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7V9"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="453"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="931"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="971"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1062"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1254" mass="135625" checksum="3482EDD8E73A8613" modified="2018-01-31" version="1">MLPNNFVVGGQSGLPQSQPQPGPQQGIPNMGIDQRIWIQQQQQLAQIRAQQQANGGQIPQQMLELIRSRNPQVMAQQRQFASGMPQMGVNNSPFPHDPSQALQNAQPQFGNPPGGQNFGIPQHLQGMQRNSNQMFTNQGSQMRQLDLMLAQNQQNQNGLPNQNPMAAVLQRQFAQQQSQAQQPQPSQLSSMGAPPLPPGIFGNMAMQPNLQNMQQHNSMSQNRAAGGMVSQMPDGQVQGQQPGRRHVTLAEMQVKANEFKNAIVAGESRIRNLREQALTSHLPPESVAQEISKVQKEVMERRQALQKIMQYLRPTGANGAAAGTFPNGMDPMKMLATSPVPPQRLPGAPQNAQMGWMQNPSQPQFNSPRPMSSPAAHLVPNPTPQPQPPQMSTPQLPQMVASQQNQPQRAVPTPMPILNGGPPPTGGAQPTQRPNPISNLVPVTFQYGPLNRDTFTKAYFQQWLPKHPIDQSILSLDGRNIDLWALHAEVMTMSGYKCFVQQPGPNQPGQILCTLTIVPDQWPIIAGRLGFVNFPGDAREPAKSGPVVAVHLERVYKQCLHEFDSQYLRQLIHHRKMLGLGQQKPNGMENGGLITAPQGLSDLKDPKVISEIMSYANLSVQEMHARGVQPQIISLVERNREQLKSTLETQRSFAQGIQNAAPQSQPRSVSNPAAMGNVNQMLHSQAGMNMTNAMNGVVKPPMQPGQPAQPMNMPSTSTTAPNGQPQQRPGGSALIPISATGRPTQAQTTAAIELVRRLKEENKHVGFPTTRPLHIPDGQRLEYNAQFERLHRLVTALDQKLPHFAVCMKEEVIKKLVVMIQAVQQQRDALTSNPSQYYMPLAWVIAMQTQVTQTEQVFHQWVNSAMRATQQPDANQSHTGANAAAQPGPSNQQIRPPAPPLARPPTAQTVHTPAALSPPGPPAHTPVASGASPQGVMTPSISKKQTPKPSGDVASASTPTHVSSPQTPKSPKNRAKPKAPPKPRKPSTKVSSVSSPNAGPSETKAPATPAAAATPVSAPTPEPSAGSKRPREEEPIASTSTSTPPSAKKIRTDWDDAPSDAPPKRDAEGVRTEEDPVKLLEQMSSWLEGDGQDHLRTEIAESLDEILRAYPVAADDGMSLSFMDSINVAGCSSPKPAAIDPAEFFDFTLYGLPEEDAGSKADTPDLVQASSSVGPSPGSASETEVHLPASASTGADTAKIADPKGEPPSGGDSMSQDLWRAIDGGESAFYNSSDNWKWDQTMQPLDQPWAIYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7W1</accession>
    <name>A0A2G8S7W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7W1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7W1"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="58"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="624" mass="68563" checksum="05C28F6758939339" modified="2018-01-31" version="1">MSTNYDIGKVRALDSRPPRNNLASPHVHGVAVRHLNERRRKLLEDIDNATFSWFHVKVAFVSGAGFFTDAYDIFAINIVSVMLGYLYGAEHGTSDSETISSRSLSTGQELGIKIATPVGVLLGQLLFGWLGDVLGRKRIYGMELMIIMVATFGQALCAPSISINIISMLIFWRFVMGIGIGGDYPISAVISSEFSSVYIRGRVMTAVFANQGWGQLAATLFSFVIIAAYQHSFLHDPPSTVLQSLDQIWRLIIGLGCIPAAIAIYFRLTIPETPRFTMDIERNIRQAHSDVGVLLGRDQAYTVEVEAISQRIQARQATRHDFRTYFSKSENLKILFGTAYSWFSLDIAFYGLGLNSSVILQNIGFGTSSKKGASEAMVVYTTLRNLSLGNLILSVAGLVPGYWVAFFLIDRWGRKPIQLMGFSVLTVLFLVMGLAYDKMASSSGGRIAFVVLYCLANFFQNCGPNTTTFIVPGEVFPTRYRATAHGISAASGKLGAVIAQIAFQWLKDVGGPGKFLDHILEIFAFFMFTGIFSTFLIPETAQRSLEALSNESQDEFIQAVPPPEAAARYLGDFHPAPIKLNPIESHLATLQPRSPMAGSLQSHSHKLSLSTHLTTLSDISITSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7W2</accession>
    <name>A0A2G8S7W2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7W2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7W2"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF45">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="293" mass="32312" checksum="D4B73ECD3A204A4D" modified="2018-01-31" version="1">MSTALHEVPLQVLSALSLTTRTGVERLRRHQPELVDSFVPFPLSAVLVLLYEKAGELRVLLTTRDKSLRAHPGQVALPGGKVDDTDADVYETAYREAHEEVGLPRHCPYIYTICTLRPYIASSKLLVTPVIALLTDLSVLEKLVPSPGEVDRIFDHPLEAILDPALVANEDLAPKGSEDWIYEEELHCTSDIDLPWLENSTYRMHRFRSRAFAIKGLTSDILIAVAEIVYEKPTTYDRFAPNQLKTFSPILRILLGQIPVQDVASGTSTPIPKVEVGIPSATGLVQAGGQATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S888</accession>
    <name>A0A2G8S888_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S888"/>
    <dbReference type="OrthoDB" id="3357224at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="826"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1927"/>
            <end position="1963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1984"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1596"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1788"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="490"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="949"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1107"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2028" mass="222197" checksum="45C6352DAF61BA09" modified="2018-01-31" version="1">MVMTCGNHTVVHLPIPDVDNGAGLKNVIVNSAWLNVDLIFEVKRATWRFQLSPVTLPYTLSAAAVTSVEPIDAAGALSFPSAMVSQHRQHLSRLFIPPALDAQQPMNFAANPPLFSPALPTSLQQGMHPPFPLNGQHPLQTPMQPNFFPPQPGAPGRPSLHRSHPSVMQLAAAGILPPPGIPMTPLGPVPTTPFGQGFPQHMVPGLAPFPPPFVPRSKRSASMSVGGPPKAVLGGPQRKVSPMPPTPTVAAAAPTTTAPPPQKQKKLVVNLPKETVPGDGDEPPTRALFARMPLVDSEIPVQDEVRYPETSTVELYPPDSWRYHLPPTVDVFLPGKAAWDGIKQRIIEEKLERLGVERGSGSSVPHIHAPHARAASISSPADPALLFFKLNKLQQSQNASGNTSLSTSPQPPLNLSPSPSQLPPRLQNRHGHSMSLAQPPSHQSPLYNPSGAFNPFGPSATLGSDQVLDRTSPAPPSAPSDFIHAPQGRVPTSVASLAPPAVASRPESRPDFFRGFGVDIPEEEEPEEEEEQPPAPEAVPDDDVSEAEATVADTTVVSAEETEQDGTSTVAQSRIHSRHVSRLSAALSLLSVGGGLEDESMELPEEPPLPVRSPEGELEEEDLDRDDEDFDADPDQEAVGEWTGSEDMQNNETSEDESIGEWSNPSDEERARQERMHRRMLRRVKQVKQELEIPRRLPNFPRPPALTVPAPAVAESTDDDIVSNPSDEERDYFQPSSAGRRPLPPLPHSRSGSQYSAHTGHDPALAHSRNTSEQYLTPGGLQPRPAVMSQPIIAPTPRAEALNPFAKPFVFGVSRGSGSFASGAFSNASGSPGGSTPATHTRAPSLGKPLNIAAPEFKPGGFTFRPPPGMPQLAFQSQPAPASRPLPTPPMVAETVRASQGREKRQRTSSRSFEVDSEDEEGANTMTSFRFPPPGDSIPARHSAPASPPINTVGVNKDTGLNVSAKPFTFSGSLPFLPQKTEDVPQSPRLSDDDDENDENKPLLSAGSIAMPVPQIGAEELPFPPPSKPKRAPIPLDFKHPVSTNTVPAGLFKALVNNDDSERTRRAVRSRLSSRDIYEHTPRQSLDDLHVAPISHRIGRGRLFTEPARREESPERGDVFSVRRPRRSSLPPRQRDEDEESSSDISVAPMNLSRRIEMQQYEQRLEKLLEEKFDAIKGTLDAYKHLAATNSQAINPATEAKISEVVTLFRSQLQESAARGLDEGVMDARGEFDFELLKGIIEQSHEESRVILQREIALLLQPQRSLSRERDIELKNLIDDLGNRTINTLANAMSQLGARLQAVEAAATRAPSTNKEHLFQDLFQKLLPHIAALRTDPIDYDVLTARLAQAVKPNISQLIDLASDKRETAGLIVDRLLPILPTIQPEIDLESIVGRLTAELKTIVGPLDPHEMKEQVSDLVVERLDSRLAVRDRPLNVDAISEKVAESMRGLVAPLAEVQKKVEELASKEPAVVAQELDLSSIQKEISGALADLPQRLSGAIDALNNAQTEFQTRASQPANDASAKALRSIENVVSTISADQTKLVEQNQEFADFCQDIIKHINSLPEAMVEATKVLQNAHAEFATRDTSQKDSEEIKRLLTEKSSLEVQVAKARGAHGQVRVEKDVLNERLKVAEAETDRLIERVEGLQDSMSKKAADMIALEAKNVELEEALARALERLKAADVQAQSQQEKLAELEKARTDFVVEKQQLIAKVDSLEVKVTYITREKDTLADEVAEQKRRNDDLAAQQSNFDELRQATEQIQMLASMIGHVDTEEVKELRLIRDRSKVLEGEHAAVQRRMKDLETKVANHEKVTQSSRQSLLQARQRAEEWERRAKEAEGQLEVTQTKLDEVEHSHSQLDADYSLVKLQLEERDAEERLDKDRQNKLRDQIASLEGQVTRLQAEVDKAKKGVSTTANVLQPAARYQNGKMHPPPRPDSRASTVYNHSRAGTPKAQYNGTTNDVRVVTPPQPSVRDSIHAPWRQSTLATPVTPKSRYPSQYKNFRAPSPTPSVVSVAPTLGEDGWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8I7</accession>
    <name>A0A2G8S8I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07666</name>
        <name evidence="4" type="ORF">GSI_07769</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2731295at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1485"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1524" mass="168802" checksum="62C2628534ED831A" modified="2018-01-31" version="1">MLLSHRHLPSPKLWLYSIMPSVTFPVIRHHGPLPALPPPPLHHPSLHLHIVQATLCSPTYVSDSQLIDIVTYLLDLEPIRDGVESLILANPFLIERARTLRAVIISDVRDIQDRIPPLHEQFPFPSPFIQAPPPLPPLEPSRPPRPALRPAWRASSMFPSPLAPRTPRFHACTPQRPPVPTSLSPSISPPRRRWSTRPTVPTSCMSPSRHSSRYLHRHCLRHLPRPPSDHQAPRLLPTGKPRKRRRPPPRPLSLLRPPILPPLPLHLPPYPLLQPCPPAPAPTNPDPAPQPQRREELRQPVQRSGLRWADTLLPHNGPRPWGNPRTAPKPRINEIINVLVSRLPTGHDTCRQYRLPDPVPLHLRPATTALKDHLLASSFPVRDVHWGTSGRVLSVVPTSTLSAADVHRLDDRVRTLLAQPGITSTPYLYKSQLSVPNLQSYECLPGGDTRPIDPRAFLLTAARRSPIPAWHALDPSTVLAARWGNPHSTSTTLFIDLLDTPLFATLRSLHGSSLEFGNFSGIRQVHACPVSSPALQCANCLVYGHPASTCRRPPCCAVCSGPHRSCDHTAAAPEASTSCVNCQGHHPATDPACPARKAALKARNDPSVSATQARQRGLPYHCRQCQTSHVAGKHVPREGRFCRSCNVAHPEGQHVRPPQPFCRACGTPHPFGQHVRAVPMCPPPTGSSGRAQPDADGFIAVPNPRQPYYGALKPIPAPGGKTNNTGPGDRTADHHYFGTTADSTNWNLLEPPVKGENRPHPRVVCYVNRRLGCKRAFLHPALIHRDAMLLGLDLGPHHTVFILNIYNDARSNSTLLADLHGLLHALPATVHLVGGDFNLHSPNRDPLGVRRLPVPTRHLDSLMGAWGLRLLSHRTSPPTFPHNRALRRVWVRPPGAKHLLKRLEVAQNVALRWVSGQFRSCAIGALQSMTGIPPVSIYCHKLQQSYRLRIHTLLASHPIRSLFPALYAPAAHSPHTPFYPPPTSPRASLYHSAVASLDSLHHLPDITEYDRRLRSNLPTPGYLRPRVHTSYDPLHPLCQPGNRVIDRFGDRLTFFLDHPKKKDADAIELWIRTSLTPRIANANADPASLVLFTDGSAYPDGSSCASGFIAYYPDTTVLHSAAETRGHGFAPDAELYAATDAAAYALTPLLPTVTRLALFMDAEAHTVEIHYCPSHAGVPQNEAVDSLVSGALRDRDGSGRHHDFSSFAYIRRSLGLDAQRRWDALTKVPKPDDPESGQVVPNPAYWGHDYLQSLDTRRHHPTDSRSIIRRFGDLSITTFSRLMRVITGHAPIGAYRAKFRPRAAQPTACPCSYHPRGPLQDRHHILFECPCYYRGLLRPAHLDNLDPFPIILSFLHLNPSAFTFDDGPPDTTDWDADDLPPLLSNSLHRVADLARCHSSVASQLRFPGWPIPDRERAADRFLLHAHQRPLPLDVLPLIPLGHEVGLHSQVNRHSLAYRARGHVYPLFEYSFHDDRATLRPVRHSITHYPHAPPNGRLSPSPTPSVVSSSPSLHEATLGAEEAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8W8</accession>
    <name>A0A2G8S8W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07680</name>
        <name evidence="3" type="ORF">GSI_07755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8W8"/>
    <dbReference type="OrthoDB" id="2755060at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="513" mass="55617" checksum="DC831E17D8C6E559" modified="2018-01-31" version="1">MSNLERLCLRAEQSFTAYPYLLPAFASLQTIKVLTIADVGVWSCEMVRTLQSELLIASILFQPTGPDVDPSESFVPSRHPLQLLQRSASTLRELMCGFWCDAYTESEGLLHAPETIYPEVRSLTLCNNVAPSPIPYIHALPNLTRLASESHRTIIGEYVQLGVSHAQRQMNIMLQKLALTDDGEGVVEFEDDEPGPLVWKDIQSYNGPLSDLWALGLTFPIPRLAVKDVPGVRTPRALTEVLASARPAHLMLVYEDQPFSSVLQSDFLDALRSEGAAGLRFLGLTIDVMAGDVDRDLDVGQALADIEAVMSGLQLRDVQLVLRDITPEEDPSFPVFNGLGDPHGHAHRQADTTTNQPTRPGIGDPAQGAPSLPTTMAAETLASLTLAERTLEEIDVQAFVRRLSASIPGLQDAIVSIGRPRRCGGTLRMACLGKNDDKVASHVYTAGKIRYREFKAADLEERGLAELRSGGVDVPNPGPSWASLSRAWYRGIRSAREGGLEGLVAGAAGAGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Q0</accession>
    <name>A0A2G8S9Q0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07186</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Q0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9Q0"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="362" mass="39076" checksum="8B1629E989B09D91" modified="2018-01-31" version="1">MSTPLDPLSPQSHIAVTPPAIRGSPSVLVPRLFKTGSPPPAPISPPPNGNVPAEPPGPSTFSAAQWCFSSSIIRTLRRMKTAGPFLNPVDPLELGIPHYPQVIERPMDFSTIERKLAASNPSKPDPNPTYARYYRVDQFVQDVRLVFANSVKFNGPEHPVTRMGKQVERIFDKQIKQMPPPEEPEAPTPVAGPPLFPPPSSSTSSPPSSPPPKKRARRPPVPVVVWAMLICSATEPTTSAGMEGMNADSQNHDLPICIWGTVVPSVLGSLTHADTSFLSLCLAFVSTRCANTQPAPALDAKQEFKSQALCVSLEEGGSPSTAPSIRMPYWRKPSVAKLILKLDTKSLSPPTWRLARKSASAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA59</accession>
    <name>A0A2G8SA59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA59"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="109" mass="11790" checksum="D7B24F06801DB3D2" modified="2018-01-31" version="1">MTPASYMPVVFVVSGTEISVAAHCAVFPASRHPDDAPVDDETAAVFEDIGTVFAQFIQHGIVLQPPVGELASCPVSGEMMPSIPLKTSLPARSVWMRFLEWFETVVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAT2</accession>
    <name>A0A2G8SAT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAT2"/>
    <dbReference type="OrthoDB" id="3365514at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="475" mass="48625" checksum="389FF9D78F82148A" modified="2018-01-31" version="1">MPPKPRPIRKPTSTTGNVPLGPPPPKDVATNAASTSMPPPPDPAPPLGILEAEITALSSCLQAAVIKKGQIYGFYKDVQRLGIQQYAPKPPRSLTSALGREIVKYDQLCDAMESHLLRAISVLQRDLAREEQRIKAEEEAAAAAIPKPPSPSLVTGTSPPGSPMQTQSQTETLPDGSVRPRLPGGVGVNVVRRQSTISLSSLSRPAAPHKLDLSASALRIHPDELIPSGLSSPVTLAPRSARAPSIPPELVMAALNDVASRPVDIDLTVDGDIDMGVPVGSSAGGPMRGMVHIDSSIGSSADKPIELDLDMDMDVQFFPDDAAAGHAANTGMFVPAAMGQQGPMVKPKQEEQLDLDLLGSFQGVQGQGGGDDLFASLGNAAPGGVPASSSGTSTDAQRALLAGLAGTPQAGNASGSIEHGQGSFDFDMPFDFNAHGSGGDMDMSGMDDIFNMGVPPSGGSGPGADGAAASGNGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBC2</accession>
    <name>A0A2G8SBC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBC2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBC2"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="69"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="556" mass="60926" checksum="BC74F7D904351FE1" modified="2018-01-31" version="1">MPFGILEDRKLDSVPGTALLATKGNQPTIGDASGLKRGTGKYSHIVLIPQPSDDPCDPLNWPRWKKEVCFWMLVFTSSLSGTLTNFASSGFFSLAKEFRVSVDEVASSFCASFAGTAVFLLLQLPISIKYGHRIVYLLSIALMFMTCVWAALSQNLVSIRISRVFQGFGVAAGRCLIANTIEHLFFVHQRGSRSCMWIMLQNIGITIGFLSNGYVIKLLSWRAGFWFASIACGVCFIGVLLFVPETTYCRQLSPSTAGKESVSEEHDLTEKMPTANHHVEPNVTSSSPATLLSHLKIYNGTFSDASLWSLFLRPLPFIFSPVTWFAFFSVSVPSVCIIFIAVCSSTIFTVTYGFDAGQIGLITIGNIVAIILALVFTGPLNDWWVVWMARRNRGIYEPEYRLVFMLSMLFGVFGYLGWAIGNDHHMPWIGAVACLAMVSLSLVVSSSTVIAYVIDTHGANASHIVALSECAVNLISFGATFFANGVVLSAGVKRTLLVVAACQAACWVTCIPMYVYGKRARSFIARHPRLFPAHADLSPSETPNLNLKPSESRTQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBI1</accession>
    <name>A0A2G8SBI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBI1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="485" mass="55219" checksum="B5320F0CDBE02DFE" modified="2018-01-31" version="1">MSPVCLWNDELVNSFYRFIFADKASRAPYLYGLELPDPFLYDVRGPLFSTVNDRLAAILREAVHLEYLCFPSSVEVDPVLTSAANATTLRELHVAFVSHMEPSWKLLSSFQSPLLSLYVEEDDGAYDQCFASVLTNDLANFAPTLEILDLYKLVLDMSPDSVTTQFAAVRTLKIRTISDFDGLGLLLRLFPNLDNTLTLSEVMNTTDRSHSTLRERSKEAQRTHSWPRLDRVVCDAQSAFLLAVQCPIRRMDITVPRFHGKRYLASTLRDNYPRFLYIRISFNDSLADLDDLFPCTEGAETLTHLVMVADFEIRYMQKGKKGKKGKRQTVSWKQFRDKLVDSMKHLHLTHLRLVLYYTVIKPTQDSVAKRDSVNTAGDADLYPVALRFSDAMPSLQYIFVTTCGHMHDILPGNPQQASPPRTLLNKWHTSKAWRAVREPLPEDRQNGSNADSTSRAPCMELSWVAAERVIAQEELELSPNEEKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCU6</accession>
    <name>A0A2G8SCU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06298</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the RIX1 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the IPI1/TEX10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCU6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCU6"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF2">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein Ipi1 N-terminal" evidence="7">
        <location>
            <begin position="133"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="752" mass="82712" checksum="346E8D233D661813" modified="2018-01-31" version="1">MPKSTKKKKDKAADFTKAKLKLGKGKQTPSNVVDTSFKARSIALPTQKIAVEKDEDAPSTKRKLTFDALLVHLKHYNASTRKDAVLGLRELLETHPQLTLTHLTPLINGCDASVRKALLSFFSWLFRQVSRDTLAPHSPVLLLFTTSAQTHIFPEIRIDAVRFLDIYLEYIPEVTIEGWMHPGGGSHGSRVMEGYLGILNAGMTFGEGGDTGPVQATSTASVVLSPTSKLVVLRSFESFLAHAASSSWNAKGTIESSAGRLTTPTWYLSSSFASTSAFDAFDGLLEPKFPSNGGSLRLEDDRMWSPEGSEHSEENFVGKFSLATDPCWPLHDVTDLDDAVAILRQEGRAGLGNDVEIVCTEHLARTLHPTLVSTFLDCAPTVFSPSSSPPETELHMVTAVCRICRTLYGRLLQDTAESGTAHHSAEMNLQTILSYLSPYFPFASTAPNVRRDMKAEQTFQDLNLIFCELSSSLLLVSQRTTAHRPSLRNTPRPGRSGGSELTSTPVLTTHSRQIERISAYIMQLLQGQSPAPSQSLPRPITPQAYIALLPTIWSLANSPRLDVSEPSSSIFSVVVDHAIRASSTSAVKRHTVDFIGRLLLLNKEPEYMGHFEASHSPEHGAKLEEWVLQLPRTLWELGTNHLATTETIVRLLLRLAQRRSRLLQPSTFAALRSRLLPYFSITHPTRGKLPGPYAKLPVQSPLRRLVLDLVSTIVAQGYRTSNMDDGLEVTVSEAVQGTPEASYWAGVLARDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCX9</accession>
    <name>A0A2G8SCX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCX9"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="11612" checksum="FBD8660BA56D44FA" modified="2018-01-31" version="1">MSALVETELRRVETTVTVTVQSEVLRACTNSPPGRPVPCLFTAHRELIPITSALAVVPKVDLPNYSATKASLHSWAISLRGQLKGTNVQVMEILPPLVESELHDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD50</accession>
    <name>A0A2G8SD50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD50"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD50"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="32"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="117"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35109" checksum="AB126D52A240EC0F" modified="2018-01-31" version="1">MSAERIRVAILDDYQNVAFKFGDWSSVQDRLSVDTFPDTTADEDVLAKRLQPYTIICAMRERTKFRASLLDRLPNLRLIATTGRQNAGIDVAYAKTKGIVVSGTGGKGNSTLEHIWTLILATARHIVIEDARVKASAIPWQTTIPMGLAGRTLGLVGVGKLGSQTGKIAKAFGMEVVGWSPNLTPGRADEAGVTYIATKEELFKCSDIVSLHMVLSERSRGMITAADLALMKPTAFFINTSRGPLVDESALIQVLQEKKIAGAGLDVFDQEPLPLDHPLRELTNVTLSPHTGYVSDSNYEAFWGQTVENIAAFLDGRPTHVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDA0</accession>
    <name>A0A2G8SDA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDA0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDA0"/>
    <dbReference type="OrthoDB" id="2392202at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="4">
        <location>
            <begin position="275"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="346" mass="37681" checksum="ED398CD0D0FF224B" modified="2018-01-31" version="1">MPPEGCAIAATTAATTGSTADSGTCPPPPPSSKPLSPLPILKRSRSPSLPVSTMDSDLPPAPQIDGEAMLEIFVHESIRFTGMPLNSDSPYGDGKRLAIIGNKALDAAFTHLLFDKRPMMTADTLDCEVRKLPDLIEKWVEGYKWREKVRHAKDIDIGTPKETRYLMDAYVGAVFVGGGYRAVLDWIAALVDPSAASPAQQGQHAEPDPKRFRLNQPQQMPPLFPNPAPFPPLQPTYPQAYPQVHHMQHMAPPQPPIPAPPLPPNPLAPAQPQSAFLPLFNQTAQQRRLEVQYPAQFTGPAHAGRWTVQCLVNGMEKGVGTGSSKQLAKEEAARQAYYAMGWAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDK3</accession>
    <name>A0A2G8SDK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06554</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDK3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDK3"/>
    <dbReference type="OrthoDB" id="2507344at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="36"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="229"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="673"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="694"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL31850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="713" mass="79020" checksum="7C3FE30E10D94621" modified="2018-01-31" version="1">MGDVQPDDPMMQKAHEVLKDTFGFASFRLEQEAVIRRLLVDNDNALVLFPTGGGKSLTYQIPALCLEGLTLVISPLIALMKDQVDALVTRDVKAANLDSTQDASRSAWIKNEVMTGSMKILYVAPERLNNEGFMAMMRRVRISLLAVDESHCISQWGASFRPEYLKIARFAEEMDVERVLCLTATATPSVSKDICDSFFIDRNAGVFRIPVYRHNLALNVEAFDNMGQKVTRLVSILKERTGPAIVYVTLQKHADEVANTLRTYQMDAQTYHAGLPSEERERVQLNFMESDKGIVVATIAFGMGIDKANIRQVIHFHMPKTLENYSQEVGRAGRDGLLSHCYMFLCAADLPVLEGFARGDTCAKRDIELWIQEVSLKQPASDGTLDFNLYKQSKDYDIRQTVLNLCYAQLELDYGYIRATTPFFSIYDISQRDANGWSKVLANSSAAAKAIRTYWSAKGNGYQIDTVLTAERAGIERSDISRTVNGWELDGHITSKASQVRARFMVMKPMPKGTKDIKALANQLYTGMVGRENEAVEKIRKVIEFATADDCMAQGLAAYFGDEDAVPGGMCGKCSFCLSGAGVEFSPIAQSIPDATRLKQILDACPERDDPRLLARMAFGITSPRLTYGKWSTAHPLFGSMVDVDFSALVAAFDVECKRAGYAKAEAVAPARTSQKRTYSQTKTSSNYASSSRGGYGRGGYGGSYKRGRRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDR8</accession>
    <name>A0A2G8SDR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDR8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDR8"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="103"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22187" checksum="C780C92E30F16A00" modified="2018-01-31" version="1">MATPRHEFYETDENLTLSIFDKGAEPEQVKVSFEPRKFFYSHGDKSLVLEPLKGQIDVEKSSFTVGKVKIEVRFSKMAQGRWGALTGDAPDPLAAFPTSSAPTTTTVRKQRKNWDGITTEILGQDKLLTGDQDPNAGGDAAVNDFFQKLYADADEDTRRAMMKSYSESGGTTLSTNWDEVGKGRVEVKPPEGSEWKKWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE10</accession>
    <name>A0A2G8SE10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-ketoacyl-CoA thiolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06693</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE10"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE10"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="288"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="43658" checksum="8C405B3B771D2835" modified="2018-01-31" version="1">MLSRLTARCSLRSLARGYATQLKGHADILAKSPDDVVITFAKRTALGRAKKGQLKDIPVDELLHALFKATFERTKLNPALLEDICVGTCHPPSPLYVSRAAAIASGIPAEVPISTVNRLCSSGLQSIVHISNAIRAGQIELGMAVGVESMSLNPRPTPEVVPTISENGQARDCVQPMGWTSEMVARAYNVSRQKQDEYALISHTRASKAVSEGTFADEILPVELRGAVVSVDDTVRPGVTLESLAKLKPVFLEDGASTAGNSSGVGDGAALCILTSRARAEKEDWDVVGKYVASAFVGVEPRYMGISPAAAIPKVLAQTGLSKEDIDVWEINEAFASQFAYCVEQLQIPIEKVNPNGGSIALTHPLGMTGTRQVVTGLAELRRRSAPLLCTSMCIGSGMGGAAIFVNEARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFW4</accession>
    <name>A0A2G8SFW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFW4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFW4"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="446"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="724"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="853"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="971" mass="106459" checksum="7DC8F3EF81489C37" modified="2018-01-31" version="1">MGFFVAPSPSWFTTVLPLSPKSDLKQPSASQLASLTERAASLLSQDAKAYASSSSAHSASDAHFLKTILSTGTLSDKLSALTLLVQASPLHNTAALDGLRSMAQRGRAKGGRDEGLKAIRCVVDWWVGGGGPSRKLRYFRDQPLLHPDVRDAHLLVWYFEDWLKKYLFSILQILETFSLDPLNYVRTQTLAFLANLLRAQPEQEQNLLRLLVNKLGDTEKSVCSRASFHLLQVLQTHPAMKAVIVREVRALVFRLPASTAAQATPSASHTHIRFTDDDPSTSKPKPKEKPIYKDIRWNSHAWYYAAVTLNQVVLTPSAGDRLVARTLVDAYFEMFEEILGSKTDNDDTGSDKDEGTKGKGKGVKGKEKDTGKVKDAKKRKAKEIKGEAGFVEVEDSSSRLIGAILTGVNRALPFAQMHLSSESSAIFQKHIDTLFRITHTSTFNISLQALTLILQISTAVSVPTAPSSKASPSATQSTTAFSTSISDRFYRTLYASLIDPRLGESNKQALYLNLIFKSLKADHNFVRVAAFVRRFVQVLASGVGAAGAVEFVAGGLYLLGELFSTTPTLKQLLSHLKPKVSSTPDAPTYDARKRDPQYAHPFASPMYELLPLLNHYHPTISLHAHQLLSSTPITSSPDLSLNTLSHFLDRFVYKNPKKPKPKGQSAMQPSLDNASSAHGVTLVKGEAGLGVPVNDEKFWKRRVEDVPVDQVFFHTYFVRKDERDKKKAEKVGKRKGKRGQEGSDVEESESDDGAIGAESQEEGDDDAGEDVEESGDDSESEDGGFDLASAGRKAAPAGEDEKEENESEDDSDAEEAEIWKAMKATMPSEVQDDDLMDDESDDVSSDLNGLSGIDEDADGQDGEQIESDEDDDGEELGFAEDSDAEDLLSLDAEVPMGLIDFDGSDSDGGEGGEEEEWTGISSVPKEKQKGKRKRDEEDGKRGRRKKLRSLPTFASYEDYAKLIEDGPEDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGV2</accession>
    <name>A0A2G8SGV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGV2"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="279"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="498" mass="54196" checksum="7F10C4213A6C6BC8" modified="2018-01-31" version="1">MQFTPVVPPYPSPGGGSGSPLNPPPNVIPQTSPAHQGQTPAWAQQPGGFPGQSPYIPAGPFMQVPGSYFIPPVTLPGGQTPMVQPNAGFSMDYTGFPGVPSGPPPGHTPFARTVQPPPTTPYMSAGPQTGYSAFQQPLPPQGMPGGMPAGMYPMGMGMAMPAGMPGGMPPYTSYVPMVPGAMPPGGMPGVMPAGYAFTPAAGNIPMPGGAPPQAAPPPGSRFANPKEKLPWDQMENVRFAEGEDYGPVLSTMLVYRMKARMEINPLIMPPNDALDRDYLKWNMLFPTGNCQRSSDRPGRSWHSGRNAPATWPRVTSLRVISRAFPWPIDIPATNTAIGVTCGDVIEAIHMSMYTRLSQGQYDNSSRQQRRLLSESFYHNRSTAHGVPGGRLQQTLLRSDWLGQDTMFGGLVDDERFVREVCKDNLPCTFELKCVRRYPMTETEIREQELREEEERERAMRQQQRSRSRATSRAGSSRPPTRPPSRASRVVDDDESETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH68</accession>
    <name>A0A2G8SH68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH68"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="173" mass="19338" checksum="1190B10D7C5E8E6E" modified="2018-01-31" version="1">MPRYSTLHDGVTRQHKIGTVQDYTVKFNAIAARTSFSAEDKRERYRTGLPYKIKDILATSGHDTSSITKIQAVALTMDQNLLVREEERPKQFSGRWRKKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSGETTDLAALRAELKEIKERLSAVSVNETKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH72</accession>
    <name>A0A2G8SH72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH72"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="116" mass="12096" checksum="C52CA5DBF1934E37" modified="2018-01-31" version="1">MGGHSGQLLPSLLPPSTFCPPAPKASVVCQSLLHRMSGLDPTAPASASATAVDFSALGGGPAAPPTDLLGVEESDAMQVDAEPVNKDVVDEEMDVVDNREHEKMEIDDLDNVMLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI93</accession>
    <name>A0A2G8SI93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI93"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="137" mass="15391" checksum="B8753D75BD83A88B" modified="2018-01-31" version="1">MTRGPRHDRRPTAGSLLRRGPNSGDSRVGDKSGLGGFRGDGGERDQQQYHTDNILIKNRDRVILLGGTHSREVRNTVRTLAPSFEKVIGSTIGYPWYAYAERPMWRNGVYFSGDAVLAWDVAVNVGRIEGRRRTESY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIK4</accession>
    <name>A0A2G8SIK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIK4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="107" mass="11957" checksum="79F2A43B3E3935FD" modified="2018-01-31" version="1">MFSENSRAGLVRWRQCPAQTGGQRCGSGLDALTSTVTIQKSSRQSLPLKAFIYGSTTSAQQFHETQTDTCETWKAKVIIRDAARARHAYWTEPSPASYQLQLGFSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIU6</accession>
    <name>A0A2G8SIU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_04260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIU6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIU6"/>
    <dbReference type="OrthoDB" id="2729249at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="165"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL33637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="582" mass="63946" checksum="1759FBA0DB3F3006" modified="2018-01-31" version="1">MNSATSLLSPRDPNGQKTHLVPPQPPNARFARASSPSPSSLVSDMSLPPISEKYSLPMDLSAFNGAEDDDSLHNPDLTKDREKNSSHVFSMRGLTNLGCLILLLVCLFALFAGFPITSYLLRHKQSYSGGFNLGGINASGQLPDITGMRGPIDRDTPQEARTKVDYVNGQTWQLVFSDEFNTEGRTFYPGDDPYWEAVDLHYWATNNKEWYDPVAITTRNGSLEIQLSARPNHDLNYTGGMMSTWNKFCFTGGLVEARVMLPGYNNVRGLWPAIWAMGNLGRAGYGATTDGMWPYTYDACDIGTVADQVIDGQPVQATVGNDEGNGGVLSRLPGQRLSRCTCLGESHPGPMHDNGEYVGRSAPEIDMFEAQVGGSALGDKKGAVSQSGQWAPFNWKYNPTGGLYDIVNTTISQNNTYMGGIYQQASSVVTAVDQTAYEFSGGQYSIYAFQYKPGFGDAYITWVADGKISWSIQQSVMGADSVVGISERPVPQEPMYLIANLGMSTNFGAIDFDHLTFPSTLRVDYIRVYQDPNAVNIGCDPHDFPTTAYINQYSEAYNNPNLTTWVQDYNQTMPKNKYLGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ11</accession>
    <name>A0A2G8SJ11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ11"/>
    <dbReference type="OrthoDB" id="3243413at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="736" mass="79262" checksum="B14F5F17F8D8D592" modified="2018-01-31" version="1">MPKRPVTPEIDDGAKYLTVVNPYPFRPNMYLDKPRELFAQWIAACIGSTYIRAFYYKPTSPGSIIVEVDESLPDFKALLGLHKWSEFLKDAKGHDNTVSRVYYCTYSSDRIVQKNGWKRVDVQDNWLRKRSKLFITPYPATYWCDISRHSDVIQNELCRPLPRQNFPPLPPTQPAPVVGTPEWQEWKKKQDSGKLVNAWTSNGPVPVTDAPSVRSRPAWNSGTITPLSPSLPPGLTRGGSSAGDSEASTSSGSSVSDSQPLSPVSADDDGPHVDIVSENIESALEALGLGLDDQDDSDGEYHTVVGSDFVEGPLQHTQYTILDPEEPVKSLWDDYVPDNDENGEDDDDEDDEGIMKAATKNPELCKFHNKVCKKGICKAYAAQLREEVKRKRQEERRKEREEARAKREKKAAKRAASVDSSSTGTASGATSPTMRVPPPPLGVARQRPAHLQRGTAPARTPTSPPPVTPAAVDDGDGDGDGDGDGDTDGDGRVTPTPSRQPDDDVRSVSSGGWGSVSDGPWGPVHRPRGNDWAAPPPKPSPRNPAAASSTAGRVPAAPKPAKAWGVWGAPSISASSMQRNRDGWSVSGRTQDDDNWPSAAAGPVSPPRSTSGRPARDSPRPPPQTQTQKAWGAWGKAASISGSSVRRNNAAWSSDGRNVAGDGEEGSDGRSVASSQAAGWGAEQPWGSTDAVKAARVKKSWADEVEDAMEGEFDARSVAASTESGRTWGNVSAGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ17</accession>
    <name>A0A2G8SJ17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ17"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ17"/>
    <dbReference type="OrthoDB" id="3202382at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="715" mass="79282" checksum="BF6D8BEC1B0BEE62" modified="2018-01-31" version="1">MSANHSSDPGDTSQDMPVISLATLPYDLLLNIARHLELLDIIALQRTCKSLHAFTVTRPVYRNLATALLRRCRALPLHGFQRLSDLSDDQLIDAVNQATRLESAWLRRGPKPSKSSPYLNTPDSPGGPQGGGQKWYKVISAPPEEEVDWLSPITSSYSLCATKSGKVVCWDVHRDVCLAEWDPKERWELWKCRVEFDIRTVFFTMAKVLQRSYDDRVMEFVLMKLEFFEDDQEPQFAELAVFKTIGVVMNVFLLDPSSRLLSAFVWVASSNTIGLYALLDWNKDEYVFIDTGVECSLSSNWSCILYKEQIVIHSEESDVAHQYFYPISVLQRHARPSSPSPSFVPSISERLPPITTMTASFIFPNQVQTRTHTPATATVTEDDLADEDGDVMIVMDQGITPPNGALNGDGDGNGNGNGNGNDDGNGNGTTEDGDDGTSVSDGNPFPYPPWYPESAHFVRQWWPTLASVPRLSCTVVLLADHEPETHRTRYVLAQHYFKVPLVEADEVEQIAASAPKAVAVKHGYSNGHGNGNANGGGLSPSSSVSSDGTLTMRTSLDSDDVADASPQGEQRRLKGTPESSMMRLWYVSEPFEVVCVLDGMEDDLDPDGSAERPRPLMAVDFGHAVWIEFKYPPELDRDEKQLRFVTFPPVTNDRYEMRYGGAGATTAESLEGIVHTLKVPDELDLDTVETINIDQSQGAIIISVKDGKIFILCYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJQ7</accession>
    <name>A0A2G8SJQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJQ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJQ7"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="50257" checksum="4A69F36485ACB8F5" modified="2018-01-31" version="1">MVGNAYPYTIEDWKEDIALASAHHIDGFALNVGPEDWQRRSVSLCYAAALELGLPFKLFLSFDMTYVECFVALRSSVLHETYLRAGLGPKTPPSSVLPGNAPEDIGLLRDYVADTFSHPHQLLYKGKVLVSTFAGQDRLFGFSDLREASAYIKDSLQKLAPIHFVPSFFIDPRRYPHISAMDGYFNWNGGWPIHLTADSPREEVECAKLDTDRHHIHHLGGRTFMAAVSPWFFTHYGPDSWNKNWIYRGDDWLLVRRWEQLVAARDEIDIVQIISYNDYGESHYVGPIKGAQPNSQAWVDGFPHTAWLELSAYFARAFKEGVYPAIDRDRIFMWARPHLRDAEATGDAVPRPDRWQLTDNKFWAVVLSTGPAEVHLSAGSEDAQARAWTVEKGVSKLSHPMITGGSMKATMARDGAVVAECAPAWDGFQVEENPKTFNFNAYVGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKL2</accession>
    <name>A0A2G8SKL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKL2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKL2"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013936813" description="FAD-binding domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL34306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="368" mass="40173" checksum="30C40C98F41746BE" modified="2018-01-31" version="1">MTSPRLRVAIVGAGLGGLLLALSLQKSCQDLRVDIYESTAELTEIGAGVGMWPRMWEIIEHLGLSDELKEVSGAHNPHGLISSAVPAQPVHIRKEDESEPVEFFQLPPTLYTFHRSVLQKLLARHLGPSIAIHFSKRLVSYIEPTESDEPIVLQFCDGTSAKCDVLVGSDGIRSAVRRSMFNVLADEACGRGEMEDSARIRSMVDPVWSGQVAYRGLIPSAALKSSGFEDTGSPAFLLGKNKAHAMTPHLGAGACQALEDGFILAAIIAQPTVTLQNLHVALGIYDSVRRPFAEMVLRRSRRNGFLFHFNTLGWEDVTAEQSMAGGFSAERLGEVGKALEEQFGFLFTSSIMEARGRAIDMVRALKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKV8</accession>
    <name>A0A2G8SKV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKV8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKV8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013802484" evidence="1">
        <location>
            <begin position="21"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="244" mass="26263" checksum="3C85024C8D5209E3" modified="2018-01-31" version="1">MASSLASVLVILLFGASALADISSNHPITPINGRHLRLNQRRNPYAPKLLDSPSCTLQTGLINVTSTHPSLNGYLAIPPPPDHGGVYGQVTDAMEGALRVSFCDCGELFDIIALNGPFQEAGYPAIGGTEEYPANITEYVLLVGTQQGLQGPPKPGNSTTIDKTTKNVRSVIWTIDSRNSFIPHWQHDDSTASDVPITLAHSIMFSPPLPGPGPTFLLTEYFEVFARLSPTDQPAIVEFLFVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL21</accession>
    <name>A0A2G8SL21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL21"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="325" mass="36045" checksum="BDE769E5DCFEA74C" modified="2018-01-31" version="1">MADSLAVFQNAFYIGNNFNAILYGVELVLYFMTIRVILSRKRKHAPTDKYFLLFSTVLLLLNTVFVATEAVFGEEMWIVNANYPGGMDAYLGDFASVWYQTFGTASSIVLNLCSDGLLIYRCYVVWNDLRVIAFPVLMYFASFSLGIAQLVDSGRPNSNYFAGLAQKLGIAYTSTIISLEIIVTALICARIYWMGRRYGQAMGNEVGRAYTSAAAIIVESMLLSTLTGIAYLITFARSDEVEIFFLSIYVMSTCIAPQLVVLRVVAGRAWTREKTSMIQSKLEFTDGSRTQIGGGQTTTNEKSHHDLVTTRSRSSSNDIEEVGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLL7</accession>
    <name>A0A2G8SLL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLL7"/>
    <dbReference type="OrthoDB" id="3263163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="747" mass="79210" checksum="4CB909F1F4FFB688" modified="2018-01-31" version="1">MAAKWPDIRDAYLPNLLENLRSADPSVQMEARWLTTSSASPVSALSIQDAAQARSVPELPLAAVGAARLSPAAISHAITTLSSTTRRQNTTRHLILVAATGPQTHGLNDTTPSGFDPWDDIAIALKQQYIRLHVILNIGAEMRTYHELFKRSLQLQNNSEVPAWFPVDSRRYSIRLSGRPQYVRGSAAVPIALVSTPFPDDPANNPSPPGSAPSPASPPTTSSSPSSPVLTASPGSRRSPHSPATPRTRPRAADSPQSPPGVEGGGGGLVSYLQQMHGLTKKKSYGIKAPKKTYADIRLPGSGRPILPRLEVPQSQSDIYTYPSFDGPGPDGLPPTSLPDSQQQLHHQQQQQQQQLQLPPPRRHSVDQLPSSNSNSLVVRTSIEDRRARRRGPWLPIAPLVSSTPSSPTTAASPGTLAALQSLAAMTPRLPDFVTNINNNAAKERSALTPGASDPRAAYMAVTQSPVPVPVSDAPAYYLDMNMSMNGSNSSINNNAPTWSPHFGSVGVGMSMPMSMSAPTPMPMSPPSTASIPSPSPTHAVSSPYSDAAPRPFQPTSPPTPSLAGSDYAGYSSSPPSSLSSSASSLPAQAQAQGDGDDQPFVVTPEYEAIVNAHFEEAIRSGAMQASMTNAIHSAVPALAPAPAPSPYGSQHGAQDHHHHHQQQQQQQQQQQQQQQQQQYYLAAQSQDAGYAAYQVVGHPQEGAGWAHASAHYGHGHGHGHGHGHTGPGYMAPVAGYAPPQGHWYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNZ4</accession>
    <name>A0A2G8SNZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNZ4"/>
    <dbReference type="OrthoDB" id="2750929at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="372" mass="42046" checksum="F363155C90381869" modified="2018-01-31" version="1">MNLSRRCCSIGPGISSFATKTLRSSAVSSRAALHTPAKRESYPAVSDISRITHLSKPTPVRTLFHRWFTPKDYIDLSDARGVVVSPGAPPLDFLVNGVDNDVPYIMYWRTSELNKAAKHRRLTYFPFPVNTRGFLYFWQHPTIPLASGLRFRIAQQPSVQGFLQGRDLQTPYGGSWHLPLIALASSERFGVLNDVLQKDGYVPPQLLEYCAQLKRSNNIGQWSQFVFFKGQPFYLDLGAPRSKIFLVGPSGIQGLPLDVGIFAGMKYPFKSGVVLCRFETRPSNSVAMRVLRVIEPVKFVDQYEGGVDQPQPGQLVTVNGHLQLFLSKSVDNRPSPLRQWQYDNNKDPFAWSWSQLQRKAGEGWKFPWLVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP08</accession>
    <name>A0A2G8SP08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_02223</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP08"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP08"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="656"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="686"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="716"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="303"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="751"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="313"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL35495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="796" mass="84047" checksum="D31876575CC6AD3A" modified="2018-01-31" version="1">MDPLLLAPAVHAEHRDFTAPSSPNLYDISPHPGSAYDSFDILPDSASHFPHTPSYNGSYQNSPYSSYSDLPPIEGTDDALGLFSDNPSGISITEEYEYDPSEYDVPSSGNPLLIDDHFMNGAHVSVSVTPPLNDYSSPNAFDHASPASSNGLEDDVRSHASSGSSYMHPSSPRPDISQTFQDLSFRSPAWPQGSLPDDRRSPPLSKPQSPPQLLIPDTTSPGGADGHSPPTINAPDGDGGLMGGPTLQIVPATPVSGGGVTAQNVPFQDSLGNLQPGSSSNAGPSGVQDWARQQYGAQGGQYADQAFTFPPGSSSSSALDDGAQQPQAHQQQYQRGQQFLLPQASQRSRSMSDTSLRPAPVWDTMPLGGSLDQRQGGTVNMNEILPGPGGSASDPLLAQQNFRHPSSAGPHQTTFGNQANFPNQQFASEYLTVEAPGSMRRVKSDGSQRGTHQRQARSLDIRSSNSLSPNSNLLFPPPGPAQQDFMRQFLHPTEPVTSIARGHHRRSSSGSRERGIGGLGMGGMGMSGMGGGMPGSWAGSSGGSARASPYPSPSVSPRPGYSPLPQDVGLSGPGMGMGMNVNVGMPGSLSGQMGLSNPAMAQGMNGQITVSRRQGVLQVDMPGTEGAMPMTVTRPHVTTPSTAKASHDRRKQPANFACPVPGCGSTFTRHFNLKGHLRSHAEEKPYQCKWPGCGKGFARQHDCKRHEQLHLNIRPYPCEGCKKNFARMDALNRHLRSEGGAECRKIQEELNPGSTAHLDAPATAASSTSASESESATPSGGDVKPDPDGWGNGIMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPV4</accession>
    <name>A0A2G8SPV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPV4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPV4"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12372">
        <property type="entry name" value="RRM_CFIm68_CFIm59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="119"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="407" mass="41284" checksum="2E93825318399984" modified="2018-01-31" version="1">MAPADDDFDIYGEDEGFSTIKAGDENQDDFQLEQDEKSPEDAATHSPVVGEKRLRDEDDSENQRDARNGGGATGVKSETSPPPGSNGSGAYSGQANGGNPSAPGSGMVGAAGAGAGQHDSLYIGDLQWVCTPSMLLSSHWTTDEDLRQVAQNLGVNIDHKDITFSEHKVNGKSKGVAYVECHSPENATVLKNWFDNNDFQNRRASANYTTSVNGNPFRTLPKEPPPREQRQQLQIQGGGNMGRGGGNFRGGMGGNMSGGTGINTMMNQTMRGGMMGGAMRGGMPNMMGGFGGMGGFGGMGGFVGGNMGGGGFGGGGRGGMIPQGPRGGGMMGGGGGGNFGGGGRGGGMMGGMGMGMMPGMGGRGGFTGVQGHFNPAFMQGGGAGGGAGGQFGGQDGPRKRFKMEESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPZ0</accession>
    <name>A0A2G8SPZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPZ0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="68" mass="7709" checksum="AC3EE78ED61F84A9" modified="2018-01-31" version="1">MPFSPLAVVPPLIEGGVQLVIGLYRDVAPTHIIKKADEKYDQGIDVLEEYRPFMTPDQIQEIINMAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ85</accession>
    <name>A0A2G8SQ85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ85"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ85"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="292" mass="32646" checksum="6C59017407580C71" modified="2018-01-31" version="1">MASHPNGRPVTNILRAPFDDEDADIIFRSSDGVDFRLYRVILAKASPVFRTMLQLPQPSSTPTAPSAPDDHELHVVTLTEDAKTLENVLRLCYPVEDPSLTSMGDIHSVLEAARKYEIAAVAANLRWALMCMLPQEPLRVYAIAYMMEMEDLAKKAATLFLDDPQFHFPPSPPPEFSVLPTLAVYAVHAYRQDCAVAVSRVLATEDWTSQNFVWLTCPNGMMVRMGPRNVPVQKWFEMYFELLKAALRERPSGRTVRSFFTSAGAGEAFSQMAVQIKFSFSITHEDGVASDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQR9</accession>
    <name>A0A2G8SQR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQR9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQR9"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="65"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="494" mass="54805" checksum="F98A806C379D940F" modified="2018-01-31" version="1">MSSMAASTEAPRVESDLKACLSANEKDEKQAPTLHCEDVMDVPDLARVVDTEAERRLVRRIDLRMITLSTVMYMLCFIDRFNIGNAKILNSDSGNSLQQSLRLTENQYLIALMVFFIAYTVFEVPSNYLLKKYKPSRWFAFLMLVWGTMTMLIAATRNYGGLITTRFLLGTFEAGLFPGLVYCLTFWYKPNERAIRVGIIIAGATLGGAFGSAIAFGIGTIDGARGLEGWRWLFLIEGAASCLFAPFIFLFYPDYPETVSWLSPEERKLAIERIKGVASLGHEAITWKDAWETLVDWRLYLHHLVWVAYSVGFSSISLFAPTIVEGLGFEGLRAQLFTVPPYAIAFCVVITVAWIADRNEMRSWCMAASFAICGVAFVIEGSLPPTAFTARYAVLCVAVPFAFSISGPTLSWLTANLRGTGASTLAVPLNGSVATFGQIIGIFIYKSSESPGFPTGHYTNAGFMFSGALLGLGLRYVYTRRNRKLEPGEPRWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR16</accession>
    <name>A0A2G8SR16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01855</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR16"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR16"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000006">
        <property type="entry name" value="Putative n-alpha-acetyltransferase 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="170" mass="19394" checksum="58A3E2D8AEAA2E50" modified="2018-01-31" version="1">MSLRTPSSRVSFAAVTPNNLGTVRKLNSVLFPIKYSEKFYSDIVQPDVEDFCQLIYYNDIPVGTMCCRVEEKDGQAKLYLMTLAVLAPYRSRGIGSQSLQHLIDAAVAHTKPKITAIYLHVQVSNDDAKKFYERHGFKETGLYENYYKKITPHDAWILQRDIEAKAVEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST23</accession>
    <name>A0A2G8ST23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_00572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST23"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST23"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="503"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL36882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="627" mass="72271" checksum="05CD779E1A309D89" modified="2018-01-31" version="1">MIHDVHVNCWPTSIIPYDHDFQIYIALKEEVFYDYRDRPNYKKLFDEARQSHEDLPVEKLLRGLGMKDEPLILELCLRRFSGWQYDRPFDFSDSMEVLRELSGHAQFGYFRCLHQSPYSNPFTGVLKPSMSMSVLFTDGMLRFAAACAMINFIPPIVLRIASWAMSCNTLYGIDVWRKPLGAPYECKEGLSIISDDGDPEWVDVETIEPPSYEDDNLPDMNVWEINENPEIFVDIPEKSWYRKGDVYRIRTKCLSPALLRSYKDLWEVNAVSFYEALMLAQKQIEIYVTLQQEICYDYRDQPSYQTLYDNAIDSFKTMTPHKLKRGLDLRLAPLMFELSLRGLAESLPKGMGCPVEPMDLIQYLAEVGGMPHHDKHVYYADPILRLRAVAALGWIFFRQFFWSPYLDCFETAHAASIIKQCAFQGQVLAISGFVPPIVLRIAGWLSTVQARYAKLDARTMLEDFEKMDTFWMVYEGYLERQKMEEEKRLAKVAKAPNRYRCAAEGCGIQAVNKSALRKCGGDCSLDKKPHYCSVDCQAQHWFVHRFVCKGSECPNIVEDDGDPAWEDVETYRPASGIKAMLDGKALWADHDREGPEIFIDIPNTSRYRNESLMANTTPSGSARATEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST67</accession>
    <name>A0A2G8ST67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST67"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST67"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="180"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="260" mass="28894" checksum="98569AC6B83462E2" modified="2018-01-31" version="1">MSSQPNTTLYVKNLNDKVKKDELRTQLFALFTTYGRIIDVVALKGQKMKGQAFVVFTDLAGATAAMRGCEGMVFYDKPMHIEYAKTKSYATLRREDPDFVPPTSIHVKNAPNGKLTNGGAGEKRGRDDRMDEDAREVKRERTERDDDDDEEMEIEDDDEGPKQSGSANGQIPAASQQHSARLMCLNLPQEVTDDVLAVLFQQYQGFHSVQVVPSPTPNASGQRVKMAYVMFDSPDLASVAKEALDGFALKKGWVMSVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STL0</accession>
    <name>A0A2G8STL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_00792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STL0"/>
    <dbReference type="STRING" id="1077348.A0A2G8STL0"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005568">
        <property type="entry name" value="Ribosomal_uL6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03868">
        <property type="entry name" value="Ribosomal_L6e_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 N-terminal" evidence="5">
        <location>
            <begin position="58"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL37100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="294" mass="32025" checksum="D560D2B049F70811" modified="2018-01-31" version="1">MSKPNGPESQTLTLVLSATPYITDAVEEAPIFPIGPDSRRCAKSTRPIDFKTNRNAMARSKELVPGVGRLSRSSVFARRGLYKGQKKSTKPAEVETPVTKQATVGGDKNGATRVVPTKKAPRFYPAEDVRQPKKSRKAPKPANLRSSITPGTVLILLAGRFRGKRVVFLKQLASGLLLVTGPYKVNGVPLRRVNQAYVIASSTKVDLGDFKVDEKINDAYFAKPAAKGSRSAEEEFFSEGKPKEKAAFPESKAADQKTVDAAVVAAIKKTQYLDKYIKATFGLSKGQFPHQLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV80</accession>
    <name>A0A2G8SV80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV80"/>
    <dbReference type="SMR" id="A0A2G8SV80"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL37676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="392" mass="44031" checksum="C1A05D8C629E432E" modified="2018-01-31" version="1">MVKVVDTNGSPQAIPSSPRLFVIIFTPQSQPPLTRAMSDNSENILYIPDTMSAWPWPRKLNPLYEEVEAESIAWMESFKPYTPESQTAHNKGDVGRLAALVLGDAPREPLRIAADLMHLLYIADEYTDAESAAGVQEISSIILDALHNPDTPRPEGESVIGEMTKEWWARVRAVATPQAIKHFLTAMEDYLGAVGEQAEDRDKLAIRDVDSYLAARRYDSAVVACFMPGELYLSIPDEAFYHPAVKQLQDASTELVVLDNDVASYNREQATGHGKWNILSVAMHQFGLDLHGATEWVAQHHKEVEARFFDALARLPSFGPAVGAELQEYVACVAAWPRGNDCWRFESERYFGKKGGEVQKTRRVPLLAKRPMNPEMRRERVEVQLIEELEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV95</accession>
    <name>A0A2G8SV95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV95"/>
    <dbReference type="OrthoDB" id="2739885at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="233" mass="25795" checksum="69A8C92695FE9440" modified="2018-01-31" version="1">MFIYSGNLGNCQYGPNETITVVFPARFELLDPVTAYWQWSNDPKLNKKASVANCGHIHSLTKTSDGYCLIHFSFGPCSFEGTVSPDLKTLSLTMDYPAGSPIGEPFSLTAMHTNHANVRSAMVYTGNLDWVPYARGEMMTIVVPYGVTKDAFFGLYYRWNQDPTRSRANVNAAVNGVFQNVNVESSGRITATYKDPNYTYSFTFGDRKGSLVLSNIRRGDVSDDAHFVVAYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLL3</accession>
    <name>A0A2G8RLL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_15090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLL3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLL3"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000247">
        <property type="entry name" value="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="183"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="394"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL22402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="559" mass="60830" checksum="7D34DA800C7B9A08" modified="2018-01-31" version="1">MGATPAQGYAAQKEKVGDRRGEHLQRLRQRHASESEQTRPSGTHSQSQFPGPGSGVFPSPQIPYPLQIFPHHHARSPSGKIFSPPARAQRHAPLARPSPRPLLPPPSSPTPPRTHIQKTGEMWSTAREIAAGDVVIAWMTRDILQPLVIAPGKELNSKYGYYLHSDLVGVPYGSKIRSRNGKGFIHLLRPTPELWTLALPHRTQILYLADIAFVASWLDLKLGSKVIEAGTGSGSFSHSVARTIGPTGHLWSYEFHETRASKAREEFTRHGMDDIVTLTHRNVCKDGFTVEDTVDAVFLDLPAPWEAVEHAKKALRKNRTTRICCFSPCMEQVLRTVSALNEAGFTEITMYETLLWPHQVDAAPALAPISVVGEKLKQSEARREEKRLRQIANARAGAERRAAKRKAEDDAPAGPGSDGKRARTDGKQEDEREHVPPEVQAQDEREAVEGIETAVEATGTEAIEAGTTSASGPAPATPSEVQEVAEAPRICLSKTFPDVRGHTSYLTFAVLLPAAVTRKLGAAATVFEQPSTVASAKPTPPPPGTVEGIQDGKTTESSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLN1</accession>
    <name>A0A2G8RLN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLN1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLN1"/>
    <dbReference type="OrthoDB" id="3359674at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="557" mass="63281" checksum="9067970165CBFCB5" modified="2018-01-31" version="1">MSAFGPSQPLDIPPVHRLPPELLIDILVHCSDEPSDQLNPIVFGRVCRYWKDVSCLSPRIWQHVYLFESNGTTLSHDQALCWMERSVPLPFDVRIEAATPDMILPLLSPVLSNMQRLRRCVISGRHEEEFDFDKYAFDRTRGCLIDELHLLIKGVSALDTLGINTDGASDVADDRTYSTVFRVHGPADGPQELALHFSVYALPLESVMKPIPVTSVCITEFSLEVSTDVARMVNFLRCTPLLETLHFTGWPQEGEPIQPGVLVPVLLTRLRTLLVRSTVSVRAILEHIDAPALEELFLEHTNVDFELRTEPYVALRAPPYEGESDDEAHDFSQSPWSDHATGTHIALPALSPNAFIHALPFPCLCTRFRTPIRIRIRTRMVTYIRPIRPPTPAWTRVRTGMGLRTLLRRSRPPLRLLHMDYADMRTKDFWWCFEHLPYLREFRIVGSDMSDRVVAMLAPYQRRRMAYGLANAYEDDARGSWAVRLPSLQKLAVWHCQRVTGDAVVQAFRERVRFTDRAAAEGRGETLESVAVVGCSEFLFQHGQALAETLGDRLRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMG7</accession>
    <name>A0A2G8RMG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMG7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="51" mass="5589" checksum="0410AD1BADB656E8" modified="2018-01-31" version="1">MPTAVTCVVMDSPRQDGEGFAECRRPQCPSPIAPPQFDAVTLIHSYAIAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMJ0</accession>
    <name>A0A2G8RMJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_15427</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMJ0"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL22734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="526" mass="59646" checksum="7C37324A2AD3214D" modified="2018-01-31" version="1">MNGTLILTLLSAALGYLLISLCLKFYKGATRFRSRHLPPGPPPLPITGNLFDIPKTRPWIGYRELSNEYGNLMLFRIFNQCLVIVNDAETAVDLLEKRSAKYSSRPSSVLTKLAGWEWNMAFFPYGWSWRHHRRVVWKHYQPDAIPRYYDAQTQAARRLLALFISTPHNISENIRYGVGAAIVTTTYGLDVGGDLSDKYLSAFETGVKSIQLFLSGTSILEFLPTLSYIPPWVPGAGYLRKLVEIRRATLRLRDLPWRDARDAVLSGRANGRESVVRAMMEDYACVKDKARYSFEEEAAKNVAAVSYAGTVFLLLEPFSGIDTTHGVLCNFCVAMSLYPEVQKKAQAELDAVIGQHRFPEFSDRENLPYINAIVKEIFRWNPVTPLGLARLTTSDDHYNGYFIPGGSIVMVNTWYVHSVPYTATSDPILVAWSILNDPQVYPDPDKFIPQRFLKDGKLNPAIRDPVAYLFGFGRRLRPCSIRSISDRLSTITVYQFTLSRGVVADWYRISKTVAARYRLGLQRQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNJ2</accession>
    <name>A0A2G8RNJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_14387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNJ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNJ2"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="398"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="126"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="321"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="574" mass="64248" checksum="CC53C937291D6A1B" modified="2018-01-31" version="1">MSTEFLRFILYGQTDGCKAILMLLTDPRPRGLQRGPKFAWNRGVYMLAGHLSPKVSTATANTSQTRSMSSSPASDVASNDDSASRNSLDRERILGSPPPLNGLKTDGDAPQAHQNGDADSEHLDPVQRLEQELQRTREEKDALATQYRNLLAKLTTMRTTLGNKLQQDAEELDRQEQLVQQLTAQNDDLAATVETLQSELIASNEEAEWASRELETMRSRALHDSSQETFLRERELRELQAELEQCRIERDEWEQKALQEHIEADEARTTVDSLRRDVEIERDSRRHAETNLEVEREKCVNLQSVLEDFQTSKDHDLKQAVKEYETQLIQVTQSLAEFKSRALNAELQLEESSTNNSRVQELEKEVKEKSVLVGKLRQEAVIMNEHLMEALRRLRRSSSDTNVDRRLVTNVLLSFLTTPRADSKRFEMLSLLSTILQWSDDEREKAGLQRSASSAQSPSGGSLWGRSATSSPAVKPVELQKTDETESFSRLWVEFLLTEASSGESGLPPPPRSPSRSNGSLPSTPTQASTRISPVGLNGTRRLPSFTSAAIASSPDLGVQLSSPPHKGKDRALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP30</accession>
    <name>A0A2G8RP30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP30"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP30"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="411"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="743" mass="80440" checksum="1F4F90795827952C" modified="2018-01-31" version="1">MAITLQPLPPYPSTRARSSFTPSQSATLVQTISTALSQVLSLSDSQISTPATLTFISSYAKDVAQQSLLALVWGTEDPSAKLSQVERKVRHAVFLLVERLAQLGTLDLQVLIDLSVAYTRISPSRLRALFSAAFVQSLKSSALVEEVQNSAILAFTALLSSTTHGLYGLRKTAHIILSFLRPSPPEVTRIFARNKTFVRALAYAYHARLASLAQTYGGVRTLSTAASQSQPRELDEWERLFLETKVALLDAFHILVNTLLDDVASVAQAGPALAAQAEPAFDVVFALVDLPSGGDGDLAPTAFLNRPLLADYQHAYDFARTLKDVLRRTEDARADVLEMSLREMTASADGASGSGSRTPGALKLILRSSGVPPGIDNLGRGPAPALAKADAKGKGRDMRVGTGDAGVPDEQLDVAVTQVLDLLPDHDPGYVRYLLSHSDYPYRGDAERLIGALLEGTAPSPADVDAALAREREIEGASGAAGAVQQDEFAFTRERRNVWDDEVMDLSRVKIGKKSDDAHALLEDRRFIEQMKADILRRAEEISDSEDEDEDTVDPANDDKGRGRAIAFEEELDDNDAIRVQDGGSSDGEEESDGEDSGGVGISRNPETVLELAYIQDPKVFERDGQTRRSKARADLKAQTGWGDEQIEGWKIMLEREVRIPRRNAHTPPGTDPADIVPVCSRREKRRCWRNTSSPATSQRSMLPSRKAASLLRAAGAATVPAVVAGAGDAVGVAAAGWGRWWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPK6</accession>
    <name>A0A2G8RPK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPK6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPK6"/>
    <dbReference type="OrthoDB" id="10335492at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="250"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="679" mass="76195" checksum="C6B0C1ECCC55D10A" modified="2018-01-31" version="1">MHDSKMWLIDTDTIQHRWVHDPAQIRYAILSHVWDRNGEQTFQDIQRIHAERRLAESSVVQDDDAEVPVTVWEDERFSKKLRSFCAFARANGYRFAWADMCCIDKTSSAELSEAINSMYEWYSSADVCYAFLHDVDDSAAPRGPGSQFRRSAWFTRGWTLQELIAPVEVVFLSKEWRMIGMRRTLAAVIEQVTAVNVEILLHRAPLDSVSIARRMSWASNRKTTRIEDEAYSLMGIFGIFMATIYGEGRHAFIRLQEEILKRIPDQTIFAWGYFMNPLAASQSSIHDIVPGQRSSSHLLAQSPSWFSRSSSVSSIDKGTLSQRLGLPGRGGTLECTLTSYGVRMLLPMLPLESLAGTEWWTLRYLSDKRFNAFLAFLAAGDPDGDLLALLLLRPKGETTDQYTVGIVHPLDQNFNQFEARGFAVKGIPTSVTSKAALLMDVYVLNASTTVPRPNKRLYQFTCPCTIILRPWTVQHLRTYGFESDLREDECLALGHQGGRLTTLTLSRLARAASEPEVVHIHITSCPQHGSWFPPLHADVAFPSHRSLAEDLPLPSSRSLSLSSRPESETAVRQCVEDIQEWPGLARTFEGPSGSLKVELEFSRWFFGEGSQLSTETYALDIRIIDDLPTDQSQWLLSSSMITEEPETMEVAEAVSPEDSEPSVEGAVEGPPIDDGTACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPT0</accession>
    <name>A0A2G8RPT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPT0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPT0"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="451" mass="48704" checksum="262692FEF342BBFB" modified="2018-01-31" version="1">MARTKKEEIPGIPRPPNSFFKFLKATVEEHKPIGTWAGLPRKIITQEVAKLWWAASEEVKAKYAVQALRAKEEHKRAHPEYRYRPRKKSKAAAAAKTKSGRLPCFYGSPSSSSTSSSASTPSPTTPVSATAMLAGGSSSGNAFGINSGYLHPNHHMIPRGAHATGLFPYVAQSNDYPLPPQVFGLGLADSSTYAIDMAQNVNFAPLPKADQASKQFSPPSYYQPPPSYAPQQAFHPFALGHQLQTGATSQQPFQPPPLPTFQPVTQQAFPPAPQQAFQHAPQQAVDPRLLTTQEHVDAAPAEPQDDSMSYDLQTTELGTWDKEFAPLDAGFCDFMSAWNNVKASATPVPDASSATSLPATNSMPSASGTLSPAPEAVHNLNVNAEWIQAPVPPSEVQEPSPLSSDLFFDPSFLLSLDDALGQQYNELCDALQALPPSAVWPEELNQHGIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPY8</accession>
    <name>A0A2G8RPY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Argonaute</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPY8"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="297"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="603"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="964" mass="107708" checksum="014BD3B148335E3F" modified="2018-01-31" version="1">MSSTNQLIRGGPRGRGRRRGQPSGQSGHGSGSSPSTGTRGTQSGGGSSSRGGPPAIFAQGVPLTQDSRLADLELKALVEGFNRLKVQRPAAEMPLRPGWGTLGQLGALRTNFFAVRLPQDAVFFEYEIAISPKAQAKGGDRKARIMHLVEQAPEFAPYAAHVAHDRSQRLVSAKKLPQPLDIPIGYLEEGETDNPNPLRFTVEITFRGEIKMSDLHQYISGKPEHRGIDTQPHISALNLILQQYAQRNGVRVSRNKYFFPSSSERHRLSLGVEAMRGFFISVRPVYMQLTVNVNLCMTAFYVPGNLAQRMDEFHQRTGGAMPDWFADKLKVSTRHLGFTRTYVIHTIMTGKTARQERFNCPEFGGMVSVEQFFKRKHSVTLAHHSDLPLVNVSADRNRPVYLPAEICEIVPGQAYRGKLGDEQTKAMIKVACNPPAFNGNTVVNQGFTDLGLRPNAPGAALEPFGISISPNMQVIPYRILPPPAVSYHGAARPPRIQDAGWNILDVRFQVGADMTNWAVLLVNENRQEEFRGPDAPHLRTFLQAFISKCTASGIKGAEKWPRIWSVNLPPLRQDTPTRSRAVTAIHKTLDDELKRNPRQRPSFVLVLLSGVDKFIYPGIKQLADVRLGVHTIHMLLPKARDTRGNRQDQYFSNVALKVNVKLGGVNHQLDAGSMRWLTGTRQEVKTMVMGIDVTHPSPNSVLGTPSIAAVVASVDNHFVQFPASLALQKPDWNKDSKEMVEDLTRMTMERLQLYKRKNGKLPDRIIVFRDGVSEGQYRHVIMYELPKLQAAFKQISPKTPYKPKLSIIVCGKRHHARFWAPDSEHATKNGNTLPGTIVDKGITDVYLFDFYLQAHYGLQGHVKATHYVVVYDENKLDADTIQQGTHTASYLYARATKAVSLVPAAYYADIACERGREYLNVLMNLENRSPQARLKVDKEQTYQTAVRMWGNGIHQDLKDSMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQF4</accession>
    <name>A0A2G8RQF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQF4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQF4"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL23721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="424" mass="48177" checksum="89F3067EC22C19CF" modified="2018-01-31" version="1">MANTTVRGAVAIHGQNPQYLVESVIRSRIYDSNYWKEHCFALTAETIIDRAIELKAIGGVYGNQKPTEFLCLLLKLLQLQPEKEILLEYLQADEFKAGVFRYLRALAVFYIRMTFRPVEVYEILEPLLKDYRKLRHLGMGGYTLTFMDEFVDQLLNDERVCDLILPRLTKRDVLEELGDIGPRKSVGKSKLAIELALALSESRQNHLYDGARIINADSMQVYTGMDVITNKVPMAERCGVEHLLMDYKKPGEQLTGPEWIKDAIQAIEETHRRNQVPIVVGGTSYWIQHLIFPERMASLDKSGDDSPEADESAPPSTAFTNALASLPPELLSLFNNLPEQAPTADLDPQLSLSLHKLLAHMDPLVSQRWHWRDSRKVLTNLRIIQENRRLASEIIQEQSQLSSRPRYLPPLLIVQVGFSGISNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQU8</accession>
    <name>A0A2G8RQU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQU8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQU8"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="23"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="52"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="271"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="35507" checksum="9011FCA1D1CD1352" modified="2018-01-31" version="1">MPNVRFSKSNIDLSLASSNEYAYLIQINVGGQSFKVLLDTGSSDLWVVSSDCTVDDCHGVPKYAQSTSLALTDVSFHLDYLSGTVSGLVGTETVTLGEYQISSQIFALANSTADLGLASTGNSGILGLAFPAEASIPDTVGRTLVLNLLSGFNDSSARYFAFQLGGSASGSSFTVGEVDPAFAKSADDLTFTPVFRAPGALYDYWKLPLQSFTINGTSFALSKTNVKGAPAPIAVLDTGTTLILGPSQDVARFWESVGGARQTDRGWEVPCNRAVNVGMILGEGSSRKEYAIDPADISWKEGSVDGDTWCLGGLQGNDGVFAADWLLGDTFLRVRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQX4</accession>
    <name>A0A2G8RQX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQX4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQX4"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="205" mass="23360" checksum="31EEC145D992E2A5" modified="2018-01-31" version="1">MSSVPPQLFFTNDVASMDEWSRRTGIPLTTADALGTNYARARRWLLSIRSKLVQEHGWQDVTPLDSRLLFDIECPTPYRSSRGLPRSPNMRLQIPVNASSFFSRERRVQWEMVFHSALFPGLRHTVPAIADLLHLLQCLLTGMVVLIKEEQVPGEGMYRTIRGLPPVEWVTGHEAALVDIFGSSHYRQLFRAASDNRVAFKLERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR62</accession>
    <name>A0A2G8RR62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR62"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR62"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="13539" checksum="61D109D3D929379A" modified="2018-01-31" version="1">MVATLIPEVLRAGGIAPLPPRPSKRPFDVRDADWEGAGQSDPKRARGDVEDRRTVKPEESDGDDEEDEEEDRAVFLQEQIVMLQSQLAQVQAKRSKPIIKREPSPIHVPFNWSNEVIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRW0</accession>
    <name>A0A2G8RRW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_13819</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRW0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRW0"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="13">
        <location>
            <begin position="78"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="940"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="153"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="599"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="699"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="710"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="808"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="855"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="886"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="969"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL24068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1214" mass="131181" checksum="269D7994BD4FD475" modified="2018-01-31" version="1">MSVAVASSSTLQALEDASQPTTRTSSPTSPTSVHFHTPQARSAINLNGSYASTPTSTTSNHALEPPFGVSYHDFLRSWTDAHVALWLSDIKCGHHAATFRANDIRGDIILELDQMTLREMGMTSIGDRLRIVNAVKQLRVKCTTNAALSSLLNRPRGADHSRTSSLSSDHGGSNRAAGARRLESGRPAPLHLPPNSGSSDLPRLVRDGQDSARIGGNMRPLPVQPNSATQHGTPTTAHSRMNLPPLPPPPRGQPPLPPIARTPRNLHHPPGTPGASGRRTPTLPDAPPSLPQAGLLTPSSQTSGSSWSGYGLPSDPRQGNRDLRTPSRSTSPLPFPPSQPPVRNASRAATDLTHTRSSSYSLSTPTNEKPLPRPGVRNPHPFAASQLQAHGLSPIAESFMSQRSNNSTTNPSPPTYRGLAAVVRPGTPSHNPSLDDLRRKLIKFTLPDEGKSATLNVADCNGGVEVLTKALKKFNKLGADGSESISSEDGGLSIDGWGAFLDWGQGDTTRGPLSELELKTIILAPPDDPAREHGLFLHKVGRVRRGQTPPTPTFHVSGSDDEDALDNVLAAEPPVYTKAMKRASSVSILSGLGVKIPEKSTAASDGVGPSQEGPSSPTSAVNSASPTKGFRKGPSKLRNFFGQRPPSELITNHLQEYFPFTEKRVLERTRRQSIMRQSGLPGRRDSIISFNMNLPSQSRFSVSTIGSQRTTSTSARMSTASSASASASLSATAVDRVSPEPSLLSEGSTLHDPPRVSLSTDDGHSIDLSNETTPKPLQGSMSTISPHLLPPVAFPSESLSESLNLTDSQSASSVRSSRRMSTASKRMSYITELRSKRDRSDTASLMTVDEITAEVESRQETAAKSGDSDEWTKVDVPDDRQSVKGDEEEDDDDDDDDDDDDDDEEYDEDEEEEGEEGVPTDEDEGTGQRIESKGEKTIKWIKGALIGAGSFGKVYLGMDAATGLLMAVKQVELPTGSAPNEERKKSMLSALEREIELLRDLHHENIVQYHSSCIDDDHLNIFLEYVPGGSVTSLLRNYGAFEEPLVRNWVRQILLGLNYLHERDIIHRDIKGANMLVDNKGGIKISDFGISKKVEDNLMPGNRAHRPSLQGSVFWMAPEVVQQKAYTFKADIWSVGCLVVEMLTGEHPWPHLSQMQAIFKVGSAKAKPTIPPDISTDAVSFLELTFELDHELRPSAADLLKHPWIASTPGPFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSA1</accession>
    <name>A0A2G8RSA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSA1"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF0">
        <property type="entry name" value="CALCINEURIN-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="49"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="284" mass="31236" checksum="2927B3B00BAFF844" modified="2018-01-31" version="1">MSWTTTSGNPLPSTATDSTFQQTAIVHDSYDITFPPEHPGLGWTRFICISDTHSHIFPVPPGDVLLHAGDLSRHGTLKDLEVTIDWLKALPHPAKFFIAGNHDLCLDRNYEPDGLLRHMKPFNLSDKDISAARKLVRSRALRKAGMIYLKHQAAVYTSATGRQYTIYGSPAAPFYSIGAFQYNLGDGKAIYDRIPASTDILLTHTPPLRTGDLTKGGANAGCPDLRERLAHRDLENCRLHVFGHIHDAHGATIVGQTMQNPNGRIAVNAALPRLPLPIIVDLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSC7</accession>
    <name>A0A2G8RSC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSC7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="365" mass="39811" checksum="B5F15A3900853FBD" modified="2018-01-31" version="1">MSLMQFTQPEALLTARHPSMQFDMKRALSSRGHTKRKPTGDFIPVGQENYPPSLPTKRVCASPSVQQQWNAPTASGAPESEAPHPFVEFLLQNRIAALAQTQSRPSVENIPQAHASSMWTSPSMPGTFPSQPVDPQHDVDGSSQERSPSEKAEVAKGKQPDRRRHKSKASRHAPKPEAASTDIMAQQFLSFLTHNLIAEQMALGAEVTAATCAPDPEPQQCARSGFGYPEAPVLYASPFEDMLVQTTPWPAAAAVMQEMRCECSICVRALAKRLEDAAPSIATPFKLSPHPEPEPRVEEPPPLEPYFTLDDGAAPPSLSEARLGFPADIVPMPAPFPSYSHQFFPHMQEAPAPPGGRLESAYHVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT88</accession>
    <name>A0A2G8RT88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT88"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20264" checksum="A7B4BCB6CDABB1DB" modified="2018-01-31" version="1">MSASPSTNLPNPSYTGPLTCYVSREIDAPLETVWEVLSDFTKYPEWNPFVRSQEITDKTGKTVLDDQTPAKGKYLFMKTHIPPTMDDSVRVQTAFELITAYDDVNHRLAWKNLLPWWLIKAERWQAVSTTADGKTVYESREVFGGIGAYLIKWFLATNLMKSFEAMADAVKTRSEQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTJ2</accession>
    <name>A0A2G8RTJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTJ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTJ2"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="420" mass="47203" checksum="AB12945BE0CF25AE" modified="2018-01-31" version="1">MPRTRRQSAPSDQSISDWESDSNATVPSPSSTQNPSERIPRPPNRFILYRAHAWKERKEQFERDNAVDNMTMGAFGLYIGPIWQNESPEVKAYWEKQAIAAKREHKAKYPNYQYRPNRGVGPRTWSEREVRPIPKRAPCRPKSTSKPAERKEATPSQAERTMKTRSMTRQRQVAEVRTGALERKASAVGRRKPTRTMATSLSPRGDRQQTERTTRRVVLDLTADSDDEGARVEGPTQNQNAQISESPVTQEAILPRATAGREVSPPTARLPVLPVGGTFSPSFDLPVGGGIVPVEQALPAHSQFPDAFNQSFAYSEPQSEWTEHDRPSLWDSPDLPLFPQEILEEHESSSHFEAQGVPDNWNYWQQRQPTFLADFGSGPSQPIVQVDPLLVGWPTCGGQYLGQHLGSFPEPQAQAWTAYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU34</accession>
    <name>A0A2G8RU34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU34"/>
    <dbReference type="OrthoDB" id="2742801at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="520" mass="56652" checksum="B9E3AD99E74AA266" modified="2018-01-31" version="1">MDSILDMGDEANDIFEYPEGDIPMIKTPVFIPVEFAEYSPLEQDVYTMWEVVDQLASAANAFSDLESTLSLAAPEQLPNDTDEDTLFWFIEALNIFANDCQDVAMQLVNFSEYVETLLFGEKQATLAPPVRILPRGSFSERDMKEVLESAANLPKEEVAKALAALEIEVPPSPMGSQRPRDRPPSLTLSTSDVVLLPPRLPRSRKQSVGAVGRFSESTSDPECRDKDVLKKHRAYVVYGDETPTSAEDNWSAKSIVDYGVDSPFDENGQPRRSPLPPRGRPSSRQTAILVPRPLSSPVTLGTTLSPARRPPSLTLSDSQSPRSSRSTSSSISSLFSNLPRTFASITSPRTSPRRSTTFDMVGKVDQVDKPRFPAPTGNLKKVFTSIFKRKEKEGGFTFPEKENQSKFGMANLGSTLRTSLPKRPFGRRPAASGSVDATLSALALSGPMSTSQIILNADSDPFAATPPASAHIPPPPVPQPTALDGYSSMFNPLKAASRYPTKPLFGGVGEEHLDGGKPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUR7</accession>
    <name>A0A2G8RUR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUR7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUR7"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="286"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL25251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="534" mass="58110" checksum="283CE4005A08F29E" modified="2018-01-31" version="1">MSNLKQGEFVGSLDCGTTSTRFLIFDKHADIVAQHQIEYPQYYPEPGWHEQDPDELMNSCEVCIDEASKALEAAGWAKESVKAIGITNQRESAVAWSRKTGKPLCRLIVWDDARTKNTVAHFEAKLQNVGIEVKPGEFKKGKEGVEALRQISGLTISTYFSAIKLRWMIDHHESVRKAHEEDDLLFGTVESWIVYRLTGGAEKNLHISDVTNASRTLLMNLNTLQWDDSLLKFFELKPSVLPKIVSSSEVYGELVSGALKGVKITGIAGDQQAALIGNKCLKQGEAKCTYGTGAFLLFCTGDEIVLSNHGLLSTVAYQDGKDGKPVYALEGSIAVAGSAIKWLRDSMSLVPTAQEVNTMAGSVPNSGGVYFVTAFSGLLAPYWDPGAAGLLIGLTSYTTPAHIALATLEANAFQTRAILESMALDSHAELKHLKVDGGMTNGDMVMKVLADVGGFEVIRPEMRESTALGSALLAGSALRLFGWDISAPETLAEVNTKGSTSFSPSMPEADREKRWVGWKRAVERARAWEEGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUW6</accession>
    <name>A0A2G8RUW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUW6"/>
    <dbReference type="OrthoDB" id="2742797at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="103" mass="11122" checksum="CFEFB95628554A56" modified="2018-01-31" version="1">MALLTIPGSTRHTSSQSTSVHPNGQAKIAIRDVQRVYGAALEIPLDVYRRSGALARPRPSSMVTPKQVKMASDRWDAESVLEDIDTQWGTIPEGGALEGYGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVA5</accession>
    <name>A0A2G8RVA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVA5"/>
    <dbReference type="OrthoDB" id="2758477at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="46264" checksum="6626873D8FFEF48E" modified="2018-01-31" version="1">MSLPIPAELVEHAIDSLHNDVHALAACALASRALLPRARFHIWRKVTLLVDGDPLHARIQGLLKILDTSPDIAHIVQSLTLNGTGVASSEARNRIHDYWDDPEGAMLLWEKLPNLRILKFVLLSFHNGLYQLIPFACSLPNLEELALIGFDAAPKTVHPASPPSRNSLVQSHTPPKLKRLSLTAGRVSWLFLEDLAKVLLEPGMHAPLETLDLFCSVASLNSRVSPRYSTDAVFSQAWAPVIASLAQTLRHCTLGLLTEDCSPANPAHLYGSLKRCTHLRSLSLVCFVHPTDTVGHRPSLFLDALADLLLSPADSPPPFPRFETLSVELLQDYELVLDGCADACAKLADALGDRTRYPHLKRVAICAKTLEQHSGPIDDNLSVGEELKEQEALCRSCFGRMEAVGVQVEISIGGPWEGYVSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW75</accession>
    <name>A0A2G8RW75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11512</name>
        <name evidence="2" type="ORF">GSI_14195</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW75"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW75"/>
    <dbReference type="OrthoDB" id="2804180at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="282" mass="31002" checksum="A3C964CD2695FA95" modified="2018-01-31" version="1">MPPTSRFPSPPFEWNPSCARFLAGLETVLIRTTLVVHRAQRPLLPVTSLQDHLVLVAALRDRLVLVAALQPLASDDEGSGEDEHDVTELGEPDADGLIPKPDGEVGRKKRGYSFPTILGWDDRTYWRLKKKVNVDISNYLDHTLSAPKQPAGSVLNLTKVIAAKHPIVSKFRDGWPIADLIHLRLKYTSGRRGSQRVPQGPEYPKDLAAAVRALERGKAVERHPEPEAARGTGTARVGAQAESGQSNGPSPILMGVRRASKRVAERQEVREREDSSDSGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWP8</accession>
    <name>A0A2G8RWP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWP8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWP8"/>
    <dbReference type="OrthoDB" id="2744000at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="85" mass="9064" checksum="8B7EB28179ACCEEF" modified="2018-01-31" version="1">MIRGDYSGWATIDTTLQAEHLIGRDRSRGAAMNKSASGGTGKPCESDICRNFNKGTCSTPCQHNRMHKCAGCSSADHGQSACTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWU5</accession>
    <name>A0A2G8RWU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWU5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWU5"/>
    <dbReference type="OrthoDB" id="3047765at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="347" mass="37826" checksum="DBE471244DBF016F" modified="2018-01-31" version="1">MSRASKSTNKSSRTKSFRAAPSPHSSEDESPPVARSSNGRAPDNTPKSTKEKPSKPKQSRNRKVPPQNSVPTSHIDTSTDHAALGTTSRKRVQKKATTPKSKVAIVAKLPASHEDEGDGDANPAPARSHSKPSARTVQSLQSDSEQPCVLKKSTKGKVKVKSLEEVNPSSQGGRITAKKTTNRKTRGETNAQSDLDKGTTLETDAQASTSLGTKKRKKLPAPSTSNNLRVHLESDSEKHSPRSRSSSLEPPAKEPARKRHKARQAADDDGDKLPEEQESQIQNRRPSRKLGNAKDLKETREVSRSKAPPIPMPNGVRLKPKPRPRLSMFQPPPDDDTSDRDPIDFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXU2</accession>
    <name>A0A2G8RXU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXU2"/>
    <dbReference type="OrthoDB" id="3238099at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="131" mass="14606" checksum="5525B033070E01EB" modified="2018-01-31" version="1">MRQTITATSLPLYSLGAFGDVLSRCDSQRFSTLVELTLALLTSGDLIGTVLIHCTRIQSLTLIVSDAYEGDVAAALRTHSDPLPLLTAFQVFYPRMGRKMSESMVSFLRNKLLLERLDMGLHEWPKAFDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYX8</accession>
    <name>A0A2G8RYX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000040">
        <property type="protein sequence ID" value="PIL26697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYX8"/>
    <dbReference type="OrthoDB" id="2752928at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="439" mass="49560" checksum="0A2B7C960296B612" modified="2018-01-31" version="1">MASFVALKSSAPRLPPDIIRLILRFFSHDKKALLTYALVSQDWLFESRPLLFRYVKILSQASSHNFISTVLHSDRLRPWLTSIHHLSFCFTDPTAAEPFILHISEHLSNLLTIRWDSVGLPNLNTPWRPLRPEVFPAFAKFTRLHHLEIHNCLFASFEDFKKFIVALPSLSSLILVQLGWLDSPDPDESSLVLPSAHIWPATLSKLSLSAYLSRSWERIDDVLTWLSTAPTPHLLREFSFDSCNIIAASRLMAHTSLTAVNIQLRGHKILGDDSSAKVAQMRSLLSQVVHIDVLKVIMLNEYEWDTTIRILSLFRSAPSVHRVRLCLRTGHILSNDRFRLYLDNVPANKLQTALLASPADAKCNAFHALRIVEFAWYMDTDSSKTLQYQYGLLSTWAAAALASLHEQCTVEMYAYSHKSVCGPTGLSAHAGGPDFPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ69</accession>
    <name>A0A2G8RZ69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RZ69"/>
    <dbReference type="OrthoDB" id="2803586at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="912"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1289" mass="144730" checksum="526D20191977BC3F" modified="2018-01-31" version="1">MPHLDPRDICFCPLHTPVFHLLVVRWFTNEYETEVLTRRRICCRRPTEDRYVNGILAPPILEPFVFELIGQIAEYDCHLTVDGHGDRTEAPVASCWIEACPDQVSRIEWAQSIVSLNRIIDTIREPVCPDELAFEGNPIRYQLFFEPPEGRTVCARTLPRGDQDKFRNQWNASAKTHLTSWKKSRKSQSTFEPQLKFNSQCTAYTEALWDRVQPTSSGGEWAALPADWPAYGPRFYPPTFGQYQLRQVASDCDPEWAYIKVLMVIHQVYFPFVMRCPNCHSRNTKPNGWTSTGHREVHGLSAEECVIGVQFRCKDCEARRRSGGDLDATYCYSTTSPEFWQKMSLWEIPRGVPHFFHRTAVTSELFDFIVESRLSENSAAIAEHVKQFHLLEYHRRRLEYLQAFQARSKQMSLRKKPDLRNFSAPQRAGKDLNGYDGTSITDNLVGDVYARFSVARQKECEEHLRTLTATTLSLDATFRAASKASFVNDDRSRSSIFNGGLHTAVNQKSLIISYRWCMTLLHSEIGDMLLGMKKRFELLNVDNPWAVVVDNCCHFRNMILKVFPETAVLQDVWHLIMRYMICVLGGTKNPHRREVAEDIAGAIIKTKAHDGIPARYWSQEEQEERLVEAFKKWVVVGGVWNAAAEKAHHEQLEHVRKGCLARPREDIATDGSRIEGTHKGWNSLQRTHPSGVEVLTALAADHVLRHNIRVDYASPDPFSFTASTFGSHHIHLVNACAQLWNALLEPANRGERRHPADLFPAPTLQPAASEETFGLVKASSDVTAYHSFVTVKEEHNDSLINLSTEDPDEAERIMRSLGLDPSLLHKPLEHDRSQSQAPSGRSTIAFVPAALEMDETMDVGTTSGPSDRPPSQPSRPSTVPGSPKKRHTSTALSRAHEDPTTPSNASDKRTRTLQSDAPSSSAPFVSIAMPAASPSSSTLLGPVAGPSSMSAVAAASLAQRLPSIFYQCRLATPDPTAVPICLPIPIISGTTCSQILISLVTGLDPRSLKFSNDDDEFYMFMDLRATYKWVTYNILALTWVEAASIFNAALEKKRGKDAVRKTPRALMEKLEDIEKTIHFRIKNKDFKSRSGTTSFWEKHCLAVDLSWGSKRGKGKGKQIAPAKPITQKPNTCHRCLSIMWAQGEGGSENHKKGYCSDGVKQKAASVDGVIEELPPWPQPNDIFTKGTHFWPKRFARTVRDLYDTVTDGDRLGGPRAMEFQAFAEMLRARLIVIPATDTQPSCVRFKLYRGLELGEQPTNPSDVVTVEGAKYLHVTYLSESGFQEVAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZE4</accession>
    <name>A0A2G8RZE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10031</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZE4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZE4"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL26893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="605" mass="65084" checksum="B7187FC72D8F71F3" modified="2018-01-31" version="1">MSDNENEKRATPGLVHDDVDVPEDAIPKLDQQTVAVLQAEEDAHLGVKAVEAAEKVYGRYSKWFLFVGIGLASYIYSLDGTTTYNYLAFATSAFDKHSLISTIQVAQSVIIACGKPVIAKFADVTSRATAYLIVLTFYVLGYIVIASAHGVGALAAGIVLYAVGYTGLQLLTSVIVADITTLKWRGLVSGLTSAPFIINAFVSANVATQVLERSGWRWGYGMFAILVPASLSPLIVTLFWAEQKAKRLGLVPAPTTEGRPTSIGGRVWSFAQQLDIVGLLLIGTSVALILLPLTLAPRAKHQWHNPSMIAMLVVGCLLLPAIAAWETLFAKRPVVARRFLTNRTVVLAAWIGFFDFFSFYLTQTYLYSFILITKPWSLLNVTYFNQTQSVALTVFGIAAGLSMRFLHRYKWVLVVGLAVRLLGVGLMIHSRGANASDAEVVWTQILQGLGGGFASVASSVAAQAAVPHVDMAITTAMVLLWTEIGGAVGSAVAGSIWTSEMPAKLAEHLPNVNQTTRDALFGSITDVMALPFGDPTREGVIAAYGDVMKLMLIAATVLSVVPLVLSLFMPNWYLGDKQNAVDAMDLKGERAHPHADSEAEKSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZV2</accession>
    <name>A0A2G8RZV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZV2"/>
    <dbReference type="OrthoDB" id="6845681at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="Hemopexin" evidence="1">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="1">
        <location>
            <begin position="244"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="1">
        <location>
            <begin position="301"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="359" mass="40772" checksum="9864BE3F46A2207A" modified="2018-01-31" version="1">MSHRSEADEMTARYHQQEEYAKIYLDHAQTIAANDPQQRRLGEVRHLLAETLRAAAEARRLRRDIEQFYPDADVGHDRAIDWVHDNLIVPARALLHDLGLCEDPEWMEQVCRPHGVQHYHRMRRSADHLFDKNCEPARACMMKPGDAQQAYFFADVGMAIIDPRPGGTGDVIVEKPMLIVQRWSCLVAVNIFTVDAVLSNRANKHEAYFFSGEFYALVNISEDRIVSGPKEIMSGWRSLQQAGFKTIDAVLPHPQNPSDAYFFSGEMYALVRYNPGELNDSLVIGPKVITNEWKSLRKAGFDYVDSAMTNPANSDEAYFFRGSDYVLVKIRPGTTDDSIVVGPKLVHNGWPSLKEALFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S040</accession>
    <name>A0A2G8S040_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S040"/>
    <dbReference type="OrthoDB" id="2729416at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="221" mass="25666" checksum="DE965B09D372041D" modified="2018-01-31" version="1">MDPRRWGNGQRLDEGDPACRDGGKFTEAAEKAQDAKWKRLMANRPPRDALPRSLMPRPGRSQPPLYHYGFPFTNQYVFDYTRRHRLSLPVPKEDQEFFGGCTAWYFEDLADAWLKSGGGDEDDLEVFKISVSRMLMLEDLRKRCKFVLGIGHPFSDDWDGIVSLWSNYNFDDRFDRCIDPVHVIEMLKAAMNESEGQSSETPVKPQWWFDWDNDVSVFSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S048</accession>
    <name>A0A2G8S048_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S048"/>
    <dbReference type="STRING" id="1077348.A0A2G8S048"/>
    <dbReference type="OrthoDB" id="2750689at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="174"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="691"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="713"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="756"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="903" mass="97354" checksum="44307D16FD1C6793" modified="2018-01-31" version="1">MFLKALPWANKEKAKVKAKINAAPLARQFSSKLSFLMDRRAATSSGRPIARDGAERVSEDLSAACIANLCVSQLPIDGATTAGDTQDSSTSYLSDEMYQADVSSEALPPTPTSTPEGSERMTSSAPPESVDLLAAEPSDDKTPSPLTFAFADSFSDADSFSDDVTLGDPTADDYIFQCVLGDGSEGIVFLAIGRRDRKPYAVKVVPKEILPKGQYGNLFTSQFAMKAMKGNPFIIDLQAAFETTENFILVFPFYANGDLKEEMHDLGRYSEADTRTRIAQLVIALQELHNNRIMHRDLKPENILLNAVGNFVLTDFGLCHTFGRSVEEQPWRVAGVPDWELAEDYDPEGHDEAGGGDKTKLFCGTPNYIAPEVYGEGSDGWYSYPADVWSFGVILYEMLHGKLPFGLSHEQVDELDPMTCILYADLIVDGSLSEDANDLLCKLLEKKPNDRPRWDAIKSHPWFNGIDWDTVAPTEPPPVPLTITLESLPPIPDDIRNIKFGEPYASESAPYPYFQYTSPDHLQHSGSTTSLYTGSPDWVPTPSVLEGFGWPVASPGNAFAMCPRLSSAPNLQKTREVPSFRVLHRPFYGSIGWDDDDAHGDNDNNDDSSMCSALARNMRTGRVPGLGVKLPSTPGSTSYLFSRPSSSRTVPVADRSASPASTNNAPASLASSKASPRRRPKGFRGDAQAGSPFRKSPSSSSHSGVPATTPQRPSALAPTSTSSPDTPTRKAIPPERAFAPITSTPLRGTGTRKVPSRSQRPSLGTPLKQSKSLTLSDIIQFSDTPSFCLSTPESLCRSSAPLPASATGSADTSSVSRTMVASTLSGDGLLKLVGLTLKATPTSDSGEECQPLVEGVSASSSGTLPVSLPLSPSKPWGRKVVGLFKGWLRLPHLGERRRGFAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0A8</accession>
    <name>A0A2G8S0A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0A8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="107" mass="11958" checksum="06E3835D72290376" modified="2018-01-31" version="1">MLQAALAEDRSPQRSLPSCGSRGCAGLRLGEVIIPSHPGVTAAELASIDHYDVRSRHPRCSAGRSVDVVAGHHLVRHGRWQDSTRRMKYHSPEDRERGLPRRRFAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0H4</accession>
    <name>A0A2G8S0H4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication ATP-dependent helicase/nuclease DNA2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">GSI_10406</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0H4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0H4"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="24">
        <location>
            <begin position="162"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="25">
        <location>
            <begin position="756"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="25">
        <location>
            <begin position="853"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="26">
        <location>
            <begin position="932"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PIL27261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1239" mass="137882" checksum="F68746EEE93EA74A" modified="2018-01-31" version="1">MPPSRHSEAEESDFLDSLLLELDSSTAIPHTSASPTRPRVTPLFPPRTPVRANKTTSPSKRTPKTHGIKSSGHVHEVGAYPVESVDIDALLDGAEDWDWDDMNSDFMTPRKSSPVKPKRSRYAVSNETASGPKVTRCTVKTVEERVVKGRFEKVLEANMVPSKEPRRIILRDDWTHADVRPGDDINVIGEWLTDPSPKVPEISVCSKHNYLIHHPDILLTATSLSNASHCPRRPLLANMVRSSSDVTPSLVWGNFLHEVMQTCLSVARWDDKFINKQISEVAQRGLGELLRINMGMEQAIIEVKARAKGLRAFADKYIASSPKPDASLTNTRAGRGEKSLLAISQLYDIEEDIWSPTYGLKGKIDASVEAVVQDFDDSSTPFARARPQIRESTSPMPFEIKTGRAVAGMEHRAQTMLYTLLMGERYGTEIPSGLLYYTQSEEVVRVPAARNELRALLVARNELAGHMMSRLRAKGEITVSEHDGGASLDDLESFLPPTIDDNRTCGKCFALDTIPQAVEGVEDTTSDIADIYDLKTGHLTPSQAAFFKKWEALISLEEKDLVRFRKELWTMTAPQREEKGRCFSDMVLDLTYRPPDVMKPTSQKEGKIHRLTYRFVKTKSGGASLLSGHTGVGDAVVVSVEPALLALARGFVVDLTPDGVVLGVDHELDEDLILDRLRGRPGREGLAHYDDTVVFRIDKDEMFGGMARIRDNLAQLFYAGADSRMLELVVDLAKPRFTGVLEEEPVAKTAPTSSRLNKDQRAAVQKVLCAEDYALVLGMPGTGKTTVIAAVITQLVEAGKTVLLSSYTHSAVDNILMKLNGSDFDVLRLGNLDKIHPAVQHRTMAARPLAKTIEQLEHQVMSPPVVATTCLTIDHPIFSKRTFDYCIVDEASQITLPTCLGPLRFAKKFVLVGDHFQLPPLVKNRAARKGGLDISLFRRLSDAHPEAVVDLTHQYRMNSDIMLLSNKLIYSNRLKCGSDAVASQSLRLPSQKFLEFLHTKSTCRNAHCWMAQLMSESCNAVFVNTDNVPAHDSRVGDLVENQVEARLVHQVTECLLECGVQQSQIGVISLYRQQLKLLSYLLQDRKELEILTADRSQGRDKDCIIISMVRSNDEGQIGELVKDWRRMNVSFTRARSKLIIIGSRRTLQQAPLLTEFFELMDGQGWILTLPPDAHLMHDFGGATPKKRSAADMLSDISLWSSHCRKENGEKFKRAKVFGATEESILVGRPLLQDIANDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0I7</accession>
    <name>A0A2G8S0I7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0I7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0I7"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="122"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="660" mass="73373" checksum="64CBF9E51310FACB" modified="2018-01-31" version="1">MSTAAKKHSKKRTAPSQSPGLKSKKLHLEKTTEPQAKRRSRPVTSTTLADSDGTSDEDISEDEFPEEDGLQEASDEMEVTEDFAKNPNATRESHKAQRALLEQRKASKPHSALLAEAKHGWTLARQKNLSKADRTKHMNALMDVLRGKVKDIVFKHDASRIVQTAVKYGGQKERNEIAEELKGRYRDLAQSKYSKFLVTKLIRFCPTYRPSILRELQGHVLRLLLHREASGVLADAFELYTNAYERSILLRDFYGKEASLFTVTVGSDEEKERSKRGLRGLMEGLEGDRRKRILGSLKANLVTIFNNPDKGAISHAIVHRATWEYLAAVSEIEDEAEAEKLRREIFETCQDVLAEMVHTKDGSRVVREFIAWGTAKDRKHIVKTIKPHVERMCKDDEAQLVLFTSLDIIDDTKLTAKSLVSDVVASAPSLYTSPQGRRALFYLVSPRTRRHFTPTQITTLAETDSIRAKTSKKDDTLRASEVRKAASESLLSWIAQSGADVSRDPGGSLVVLEVMLEADGDKSAASDALLSALAAPYPSADPANPHPISLPHTSRLYKTLLQGGHFSHSTRTIENAPRFSTRDFAVRFVQRVGRENTIAMAQGDGAFVVAALCEQLAEHAADEVAERAGVKSWFDKKTRKAIEGAGGKGVKVLLDSLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0W8</accession>
    <name>A0A2G8S0W8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0W8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0W8"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000009">
        <property type="entry name" value="Cystathionine gamma-synthase homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL27384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="448" mass="47592" checksum="1646B44D1F4D8BC5" modified="2018-01-31" version="1">MSPIIFSSESAAQTNGHAHSNSIHTIKEHASLDGFGTRAIHVGSEPNPETGAVIPAISLSTTYKQHGVGNHKGFEYSRSGNPNRNALEATLAAIESGGAYGIAFASGSSTTATVLQSLGPDAHIVSVNDVYGGTFRYMTRVAAENQGLEATFVDLENASDDEILASFRPNTKLIWIETPTNPTLRLVDIARIVSLARSAPSNPLVLVDNTFLSPFYQSPLVLGADIVMHSLTKYVNGHSDVVMGALILPAHHAALAEKLRFLQNAIGAVPSAYDCWLAQRGAKTLHLRMKAHGANALAVARALQSSSHVEEVIYPGLASHPRNDLAYRSLSSHARAYVDRYVKERGDEAGGFPYGGMISFRIRGGATEANKFLTSARLFTLAESLGGVESLAELPAQMTHGSIPPAERALLGIGDNLIRLSVGVEEEEDLVADIEQALAAAALPSKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0Z2</accession>
    <name>A0A2G8S0Z2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0Z2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="175" mass="19727" checksum="1DC0695FD1572A51" modified="2018-01-31" version="1">MMCQGHSNWYDIFHGHTQARRNLPNDITPLASVSHKQERVQLALSCIGIGIRVCVRIWRVTQIRAEAARVLTRRAPVGRFQGTHAELRDRPTSNPRDGTTTRSRVLSRRPVVNCGRGGGTSPEEGCKPQRLWCLERVVCSFLRRLRGQRGSCAKRRSIRLRAGPGAVWGRVGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1F3</accession>
    <name>A0A2G8S1F3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">endo-polygalacturonase</fullName>
            <ecNumber evidence="2">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_10536</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1F3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1F3"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013809107" description="endo-polygalacturonase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL27388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="355" mass="36702" checksum="7A04C685397B3A47" modified="2018-01-31" version="1">MSAFLRLAALLAFVPFIVAAPSATACTGTISSLDDVSTAVKCTTLNINKFTVPAGKTFELDLASGTTVNLLGDVTFAVKNWAGPLFQIRTDKLIASSGKDITFNGNGHSFDGNGPSYWDGQGGNGGVTKPHPMMKYNVKVLNSPAHTYSVSNPAKLVMSKLIIDNSTGDVANSKSDGKAVGYNIDGFDVSTTDLTIEDSTIHNQDDCIAINKGGDIVFQRNSCTGGHGISIGSVSSDATVSGITIKDNTITNKSTGATVSNITYSGNTGTGLRKFGVLIDQSYPSTLGTPGTGVKLSGVNFAGSTNSISVASGAKRVAVNCGACSGTWEWSALKVSGGSEGKINYSDHFAKYNCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1G2</accession>
    <name>A0A2G8S1G2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase MbtK/IucB-like conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1G2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1G2"/>
    <dbReference type="OrthoDB" id="4250781at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="2">
        <location>
            <begin position="270"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="454" mass="50358" checksum="6FEF32F9281B46E4" modified="2018-01-31" version="1">MSTPSPRPPLAVQQSASHVAWRRVVVLPDDAKVDIDAPQDTSQPTKVAIDGAIVAAYRTLPRTAALVISAVDTPHQNSATHIPKFPVIEVLPPSEVLAGALPTITPADLWGVLNIFHTFYHVQETIPIVFAPSLQNAPQLTTYLLLSGLARKRHATPGDPAAFAQAHASPELFLLRETFWQGAGTTAAFHTRGGWLRGHAAFLAAAPFPYVQSFTRTDLVIAAHPLRPPKPRPGEVVYRKYFPSVGQSLEFVYFDVTGETVGTEPVADAGGVQVSRHLATFHRWHNSDHVNRGWGERGPLEKHRKYVEGLLADPGVLPVIMSWDGEYMGYAELVYLKENHAGAYVPGGVWDYDRGLHILVGEEKFRGLHRSKAWLTAIHHFLFLSDPRTLRSIGEPKKVNNAVIHVSIESGMNVETWFDFPYKRSVMTWLPRERWFKLDVLAFAEDINTPAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2S1</accession>
    <name>A0A2G8S2S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2S1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2S1"/>
    <dbReference type="OrthoDB" id="2748152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="274" mass="29967" checksum="F431DA385FF6C834" modified="2018-01-31" version="1">MRLWDAHTFRPLAPRKLKGQIRSLAFSPDGCWLTCVSNTGESHIVNVALDVAPLPDTVTSLGSSSGCPSDSEYTRTPREPERQISLSYPVASAAFDAGSTRLAVGLFPRQREGKQPVHDVSFSPDAKLVLGSAGHAAHIWDASTGRERCRLEGHEEEIRGAKFSPCGEYVGTASEDKTVRLWRTRDGVCVARLTEHTHAVRHLAFSPDGTTLSSGDNNINGRVIIRRMDDILAPTPAKRTTIVTKSLPPPSTLSRNQTPFSNDRAGRSRTKRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S307</accession>
    <name>A0A2G8S307_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S307"/>
    <dbReference type="STRING" id="1077348.A0A2G8S307"/>
    <dbReference type="OrthoDB" id="2985259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="385" mass="41976" checksum="F622F89E34B70947" modified="2018-01-31" version="1">MTTAESSAMVDSAMTEPNAVEEPTLAAYAIRKQLPTDLGTWRGPFDMHGSDHTEAIWEALGPFFADRGYTLWPHGHIFITTASEDDMVVNGYMYAGPHRAQSEEMWGSIHGVVSHMHHNALTRAARGPDAQDVVLRVLAIGEDGKEHVDLLKTVARSSWSLVNSNHTLPLLDLLALDDITFGVFPMVGYSCSEVYGGWAKSSVRDILEVIAQCLEALVFLHACGIAHRDAFKDNFVIQWVPESLRAGHNATSSRPRVYMINFELAVRFPLDSPAEERVCVGLPSTGSLPGGAKRPAAPETLSDEPYDPFKLDVWQLGKTFSDFKSTIPEIDKVLASMVDPDPATRPTAYDAMKTLLDAVGAVPPASLIIEPDLESLPPESESVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3C4</accession>
    <name>A0A2G8S3C4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3C4"/>
    <dbReference type="OrthoDB" id="2753694at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="961" mass="108379" checksum="C9EE690738810A60" modified="2018-01-31" version="1">MALSTPHPSQSFWFEEQFFTVINPSRVDFLPGIRVGDPDRNFTARDLRKAVWAVDKGPEMAYMLRSSHSDSALLARLSCDPRNPPIVTTEKKRFALNQNVLTTWKSLEQSLYAVSETLLLHISKIPEAKFPFDAFWPLPSDLGYQNDHATFQSAKNAVLRSRDAFFLLASRCTLAIALFQYRFPAEDPPAWTSVLMQRGVPPPWIDELRASPIADLSSGIRAGAFIDPLPGPACTAWMNHIPCMIAANLPVYIAWPTFQGQLRTSLCQQILHDHPCLTAYLPVLVEETPVVPSLADPKAFQSFFRWTDILDDSCPVPIDSLFPTSSDEELSRLPHGPGQRPGETYQQFFDRREAEGQRRMKTETPEKKARRLERAAKAASYPCPAHPTTTFLWIELGEINDSSVPWYLLHSDYRKVIGFSAARDMWELYPDSQKRYDPWSDEWDICPRLTDEPVLDDYSDNNNYGFPLPVPPQPTSQSFLLPLSPATIASSFQADLQRFYSGEDFAGHVFIAEGFEQVAFYRYGVILGVPPASRPPPEYSAFNHGKIQKYFGVLSMDLADRCVPTLSAFLSVALDRSTSSTISAAVFDLDPGCPQYLMKAGQAHPTLHLKVWRLSGVEYYRIRYADEPDCWFDVIVDPTTAVELLRRQDIRSRAFAIGLMVQKGVRFHTLYSPDRRDTFSIQQSPFGDALGWRPRGFTATRYDYGQYIAQAYEVLRQPRGRAAILHGGIVWRLALEILGSDAVGRAVAGPSDNIFYFGQEFRPHRGGPLYDDSLSPGEVDIICGVYKLPSKSSDPELLSWWPRPNVFDTSGLAFGYWTPWCENWFQRRLERIKAGTASPLPAKEWRPTLMFWKGAVPGRVGRFKITQRPFATFTGTTAAASARQWVLSHWALVRRCTLAVRPRTSDTRSRGSPRSPTLLWRTPYPLQVATDARTDAVAVDAPMRLDLSGARAGFNSTLTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3Z5</accession>
    <name>A0A2G8S3Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3Z5"/>
    <dbReference type="OrthoDB" id="2765882at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="46209" checksum="2C712CEE65B5FB7B" modified="2018-01-31" version="1">MVLVHRQWRWGTYSHPWAAHFTSSDTTSTFFSEHSATSASETTQTHTVSSVSTSRTATTTLVPVAAAERTTDSTTQAQTSTEAATTQTTDTTVRTTSPTLLPLSVAGETTSRSTSDRGESHSLGLSTSSFSSFTLSGGLTVSLPETGSAAQSTASGSSSTAQPVVTGSSGNSTSSDAGHGIGKGAIAAIVLGIVFALGLGALVCCCWKRRAGRRRDSTFIQYPFSSNAATGRMSQVPHVGALVPPNTPAEWDTHTADMAESPSATVTIGSPTATGASGYWGGLAMYPLDEKAPLPSPSPSPSDNNNAFEPATTTPSPNSTTAFALSFPVPRSPLSQPPVSPSRPASLSSPSSPESSSSSPIAPPPPAVHPHPRLPEGEPSALPYAWDHPPPSSEYLPPRTPDRRSTFRSSRTGPGPGPRRASAGATPKYSSGVPEVDRRPPEYSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4I4</accession>
    <name>A0A2G8S4I4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4I4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4I4"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="187"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="363" mass="41289" checksum="02D0593F6EE4AD5C" modified="2018-01-31" version="1">MPTATLPSIPHYVPAASTEEIVEWADLPVIDLAKAATPEGRAELAPQVRDAMRTHGFLYLVNHGCTEAQNERVFDIANLPFEHVPEDEKKQFAGDIKKTGSYRGYKLRNYWHIDNGVRDQLEHYNLHRSIYDLQQHPTALQPVLPEIRAFAEHNHYNVLFPVLRLLALGLELPEDTFVNTHGFDAKGETYVRYMKYYPRTPEEERKTSNVWLKGHTDFGTITILWSQPVTALQILSPDGVWRFVKHIPNALVVNAGDGMEFLSGGVYKATIHRVVQPPADQRGHTRVGAFYFAMADDDVVLRPLVASPVLQRVGIVRRFEDADAPTTEEWRRARTSAYGQTELTRKDNVEEEVINGVVVKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4T1</accession>
    <name>A0A2G8S4T1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4T1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4T1"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4470" evidence="2">
        <location>
            <begin position="217"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="978" mass="110876" checksum="98261121677B4CF1" modified="2018-01-31" version="1">MTRKFPANAVGVDAQVLKQKGNKHFKAGKMKEAIEMYGQAEKSDPNNPVYPSNHSAALYKVGDYSASAAAVLRAWNLLQDKPDAKPDLIVRLASRLAKSLSYGVRAGSITMEFILSHKEDIMLLQEEASGKPLTSANTASLEEFARIWQEWECVKLEMEDYSTKRGTCLQGLSRLPMFVKPLDKTREYFLIGTDDIIDLTAGWGNDYPYPLEINKLSAQRLSDVGFFFGGVGDGRHVLGTLCGLRLAFDKLSKEKKKRFHAHLTLLDIHEGQIARLLLIFDLLHSYNICDDVEVRDEIKATFMYLFCGLAMPPYCSGAGLYQSLSTKDPHGMPPIVHVSPSSTGPLLRILDFWTKLKKSIVTMLDGHQPMDPGESAGAPFAGWLPGSKGMLREMYESGHSSEREQIKNMLLTAEDKHLYEFKLVPEGGTPDDARTIIRENLEAYIDAFQKLFRHGKVLMYEEVWYKRFKVFFPPRELLGRHAGFKAAMKEIRAAKALERDAEDEIFDELLEYWEPNITFFDLKTADPHVFSDGDGYPNLNLDMFRTTSEIDVFNRRNGPRAKDYPRTDANLLTSEACGKWFEETAAALKVLGKKVKIELVVGGLSEELWKMQLGGDADRPKEFPRKWLSNVPDYTHGILNMAVCAVPALQDDPQAAVACNSLLNTGAWANDEQFIHTYSLLLPEEVPRYLACRLIDARPVLDILSLGSQAHPRPLSELATRDELTTWLTRLLFNTFIPGHTKFRPANVRLPHNLIAFFAVLMYLHRVGYPAHWLSEFLARVLSGKMHSDIRQYDDFYPIPVTERTVRVKPRTVRTDPWLVEFETILATAYHGVPFPIATALPPDFSRDTSDIAVWEVAAQPVQCFSTRPMFNFSSPYDPRAQLVVYRSDVVSAGTLIDDIQKVFEGRATPAPGTFFVLTALEYVHYVDRIRFKLSRWRVERMRRESARWSALAYRNDTLQQATLPVPIQKWVLVNEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Y3</accession>
    <name>A0A2G8S4Y3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_08855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Y3"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL28811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="509" mass="57808" checksum="DF6C4ABDF6FAB9C9" modified="2018-01-31" version="1">MAILPIHLPDASWYPAKGDRATLFLRFIARRFLVFGILIAFVLFTISRMFYGREAFLEISGTSQERQHSRWPGVRLPPLYSRYHQYELALPQHHWHATSHEDEPKFFFVPGHTWGLGWGNAMQEILLNAYLSYKSNRANERHSRFVFYNYTWNMDPSQDYSDYSGKPIPSRVPLSALIAVNHIIRIEGPIVGGAFPDGQHAPFAIAEEYYRTICEGRKRVLDREEIHKEIGSSMVDPITKGWVQKLSTVDDQCVEVARGQDGGIYTWIIFGEKDAMHDVWADFAASPIITHFRWSPLVELAFDNNREVFAPTTVFEAPLSTIPYAVPSAQRYAMMKGLLALHIRRGDYAVHCDGLANWSSSFLSFNSLQGLETFRIPEGGGWGENTPENIAIYRRHCFPTVEQIVARVSEVLRSESARGLESVYIMTNGAVPWVEELKTALLNTGSFKHVSSSRDTVLNWEQKYVAQAMDMLVGQRAQVFIGNGWSSVTGGVVVMRQANGFHPDSTRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Y4</accession>
    <name>A0A2G8S4Y4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_08849</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Y4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4Y4"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="819"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="931"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="787"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="518"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL28805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1123" mass="123973" checksum="5D6D6845772EC815" modified="2018-01-31" version="1">MPSSDSAGRLHAHAPGRMLHRAAALLTTKGEPVPAVADAILAVGPESEYEPLRRRRTDGGSRIGGSIRRTLSQVKGVGTTVARRASFKRPPPQSPPTSASSLSTRTASSASDEHTAPLPTAPASSTTFMLSPVSWAKRRKSQSHRRAQSEVLPTRPRVHHAHSPSAVAEIAPDSPFIDSLSVLPTPLSGMASLPESPSPSVEQPQQPESHLLQEEYHVNEVVSPVAQPSPGADAAVPQILQQGIPMLKVSAKKQKRYVFKLDPDQGQIVWESKKFRFIPIENIKELRCGADARYYREQFQLAQEYEDKWLTIVYILDGGYKTLHLIAATREIFQMWDTTLRRLYAIRQQLMSGLGSADVRQAIWEKQFWKGADEEQDQRLDFDDVERLCRRLNINPSREDLLRRFKQADSQNRGYLDFADFKLFVKSLKARPELDRLFLKITNGEPSLKFAAFEQFMRSTQKSSSSREELEQLFLRYATPPKGEKAPGSPMQTSLDLAMRSVSISGQPLPPPPPSAPTPSSAPASGPATTSLSPPAAPSPVSPLTVESATMSKTGFTSFLLSADNSAFADQHGRIEHDMTRPLPEYFISSSHNTYLVGHQLVGESTIEGYIRALLHSCRSVELDIYDGDTEPVVYHGRTLTSKVSVREICTAIAKYAFVASPYPIIISAEIHCSVPQQVQLVAIMKDVFGDALVIAPPEGRPKLEVLPSPEDLKGRVLLKAKNLYVSQKAGSTDKEIIVEAESSTTDTASDSDLASEVRHEWRKAREAEVELIKDLKSEFKKAKGALNRVRSPAPKAAPPSGQAPATPQPPKVKMSMELVSLLVYTVGVKCRGLNKKEQYAPEHIFSLSENTANKLLKQITGMNDLIKHNRTHLVRTYPKGTRIGSTNYEPHRYWSAGCHLVAINWQTFDLGYMINHAMFQRNGRAGYVLKPLALRTSDKQVLSKRTNHFLNVTVISAQQLPRPKDSQGREIIDKSVVDPFVEVSIHIPDWTHSPFLPTDSPSPIATTAPAAAYSPPTAGSATAATSARTVACRTGVVKNNGFNPVWEQQLCLPFDLVGDMRDLVFVRFSVRQEDKDDDEPLAVYCASLGSLNSGYRHLPLHDAQLSQYLFSTLFVKIEVADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5R2</accession>
    <name>A0A2G8S5R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5R2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5R2"/>
    <dbReference type="OrthoDB" id="2507336at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="425"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="584" mass="64622" checksum="97E16335E13CE51A" modified="2018-01-31" version="1">MTRIDPVHRMTRADPAHHTIRIDLVHRTIPTDLAHHMVLPDHGMGNTTVHPVQVVIHMRRNGDTVRVLCRPVNVVGTTTTNIGHVRDVTLPNIMSIIHVTARREVARGILKKVSDLTRGTRERVADPTVPVLLNLGRGIAMVLVIDPVPEAQNTTRKIVMAGLVVPAAPLSMRKGITIARVPATPAILVVREDEPEHGVVHISPPSEPEYEHTFTPSPQSHPRYPHVAPPATESLRKTLVASPERRGTVPVLPSRTRSPIARSSPIGHATVPVPVDQNDAGLTDAEQERQNRFDELAGALDRTIIDVQDGEEKREENYRANEEERQRIFVENERRREIEVEERLEAMWKKVEDRLAALPSAVAMPAGSESTSTPPGGRSFEDNSIPDAFEPSAGPPDAPTPARHRVDGAASRHAADIREAILLGKEAAQAERERALELNEAARNRMQEEHKAHIRALEDELSAVRRELAEEKMARAAEEAGRHERKRAEMVAQTDLMRGQVGDLIGVLLDRRDVKAIRRHDSSDNDGKTWGGLTVIGPRCHSPLYELATFTTIRIRAKLVMEDGPGVRVRHASEAPAELDAEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6F1</accession>
    <name>A0A2G8S6F1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_09166</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6F1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6F1"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005365">
        <property type="term" value="F:myo-inositol transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="55"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL29118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="539" mass="58026" checksum="9E9E21CF77DB3398" modified="2018-01-31" version="1">MAMSIEKAPENVNDDKGKDTQVVENIENVASPQEISEARVVAEGVERTTMFVWLLVSCVSISGLLFGYDTGVISGALVTIGGDLGPAELSSGQKELITSSTTFGALLGGLTAGMLSDFLGRKPVLAIADVIFIGGAIGQAVCHTVWSMIGGRFLVGIGVGIAACVAPLYIQELSPTRVRGRMVVVSAAAVTGAQVLAYAVDAAFANTHRGWRWMVGLGAVPAGLQCIFLFFLPESPRIMIKRQKIEAARAIMAKIYSHATPEQVDLMVKSLAEAVKQSVEISNNTTLLQRIHLILFNGINRRALIVACGLQAFQQLCGFNTLMYYSATLFKEIGFDQPTAVGLIVSGTNFLFTLFALKYIDIIGRRKIMIWTAPVMVFGLVLASVSFYFMTKKTGGNLVDGTHYSHTWSAIVLLAMILFVASFATGLGNVPWQQGELFALEVRGIGTSLATATNWTSNLIIGATYLSLMGRITPSGAFGLYAGLSLLGWLFCVFAYPETAGLSLEEVTLIFRDGFGIRESERLRKEKRALQRGERGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6H1</accession>
    <name>A0A2G8S6H1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6H1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6H1"/>
    <dbReference type="OrthoDB" id="3054497at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="245"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="476" mass="54634" checksum="5510DDE78C1E1FC7" modified="2018-01-31" version="1">MSHAVLPQNLPQRARVRRETSHLHQLRLYPLYLLNLVHSTERMYQKCNTLCRRNLLRLTGQAQKNRDGLRESGKYQFAKAMSMRSAERDPPVPIPPSMRTHREPTPVISSSSSDDEEEEDIGSDPIPAFVLPQPESPAPSPDRSDPDDDDDDDDDEEEESEEESSGQSSDEVEARTDVAQLCREGGASLIQFLIAKAIPPDEGEKVPPANVREWTYHDIASLPNAERKEWFTACREELEALRRRDVYDLVDRPKGRKVVKNRWVFDVKTDGRKKARLVAKGFSQVEGEDFDKIFSPVVRFETVRLIMALAALEDWHISGLDVRSAYLYGKLDEEIYLEQPEGFRISGSEHKVFRLKCALYGLKQAGLAWWRTLSESMKLMGYKRLTNDAGLYIYKCHSDGELVVVIVYVDDALFCGRDKKLVALLKARFMRKWECCDLGDAKEFLRMRITRIGRKIFLDQRAYLEKVLDRCGMTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S738</accession>
    <name>A0A2G8S738_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_08238</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S738"/>
    <dbReference type="STRING" id="1077348.A0A2G8S738"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="51"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL29602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="143" mass="16391" checksum="D96C1A2F6DC85B79" modified="2018-01-31" version="1">MSQRFRTNVHNRSQLLGTPDYTTPPASGRSSPFGGAVAGRENPFAPQRYVDDLEGQNDEHLEGLTAKVKILKDITLAIGSEVKDSTIQLSQMNDAFSETSGILAGTFRRMNNMAERQGCRWLWYIVFLILVFWFFIVVWWFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7S1</accession>
    <name>A0A2G8S7S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7S1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7S1"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="42"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="540" mass="59001" checksum="D67A283697E4CE36" modified="2018-01-31" version="1">MTVSSPVNDDAGLQDVGVVNKTRVAALAEIDQADFSWFHVKVCMVAGVGFFTDAYDIFAISIASTMLGYAYGNATVPGTGTKPLHMLDARQDLGIKVATPVGTLVGQLLFGWLADMVGRKRMYGLELIIIIIATFGQALGGSGLRAVNVIHVLIVWRVIMGVGIGGDYPLSAVISSEFSSTRIRGRLMTAVFANQGWGQFVASLVALIIIVAYKDALERETTYVDYMWRLLIGLGCVPGAIALYFRLTIPETPRFTMDVERNVKQAAQDVENFLATGSYYVDPDAVYEPAQAPRATRRDFGSYFSKRENLLLLVGTAYSWFALDMAFYGLSLNSSKVLEIILGANSNAFKNLYQIAVGNVILSVAGYIPGYWATFLVIDRWGRKPVQLMGFVMLTVLFIVMGAAYDKMVNHSGVAGQRAFVFLYCLANFFQNFGPNTTTFIVPGEAFPTRYRSTAHGISAASGKLGAIVSQVGFAKMIDIGGQGAFFGHLLEILAFFMLTGVFSTLLIKETNQKTLEDISNERQDQFVTGTPLRQQRPKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S886</accession>
    <name>A0A2G8S886_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S886"/>
    <dbReference type="OrthoDB" id="2746049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="444" mass="46466" checksum="FF009313EFB3DCAF" modified="2018-01-31" version="1">MPSLLTLKFDGLARNLLFSRLFYHLFRTPALRTLIIHDTLPTVDPHRLTTMGVSPPSLFPNGTIHVEGTRKVKLPALDSLSLRPAPSWALWLLFHYLELPTLVKLDLQVYTDRRSLPWLWISPDGRPVEVPVPPSGAGTDILGPDHWAIPLPALRTLHITYCTGISPPAPQAASAAPATATLPQLRRLVFPGLTELQIIHTPRVLATQVGPQASESASLPPLPAFDALFHAPDFRHLVRLALIGCVLPLATLCDALRARMPALEVLALSACTGAGALVCALAPGECGGPGGCERSTGDKDGDGDGDSDGDGDGDGDRDGERETGGAWIGMNVSAVIVSKCADVRAGCLRRVIEARVRASAVSESASGSESELESTSTSSGTLPASSEPGVPVAGGGLGTGVGRPKRITQMQVFECPGVTKGDVAALADIPGAPAVCWLPPKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8B8</accession>
    <name>A0A2G8S8B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8B8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="168" mass="19025" checksum="901E08E9AB9C9383" modified="2018-01-31" version="1">MSSLPDKYIGARQCFENALGISRDAIEDDQEEEVESYDSAVEIDEQLAHEDLDSLETDMEHFDPPITPRFQKLSVDAEGLGDDPSEGGALTIPMKRKSDHETMFSALKAASKNVVGNSTLQLYIRLWILFTTFCLAQGFIQNEHELEKMQPNFPSELPTWIALWIMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Y5</accession>
    <name>A0A2G8S8Y5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07414</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Y5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8Y5"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="288"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="504" mass="55207" checksum="82A20B7DD921A796" modified="2018-01-31" version="1">MSQSDSQIPNSNSNSDEFDPDQDPRAAFLNIEDYLAIKAACLSPYAYKDSFHYRPTDLELRECARYLSEWPGVRVLDQWKFGDPKARPQAVLETAIRYMSGCTIFRVCPEAALHTLDVFPQHHQPPPDAGSPHHAHDVRAPSPSLSPESQAALARAHACAAHAHFQKFRASDKDRTTFAADERHYRRKQTLDAGLGHPAHTSLRFALGAASESARLGHVSAIVLRVGFAAREIAEGLGVDFGLLVGRARRYRPLWRAVEECLEELYAEARKALGREAGREALESVCGAEGCGVRASSSASLKACSGRCPLDFKPRYCSKQCQVKDWSRHKEICKPGGVGKIPKIPNRLIALEWFELEDPAKPEPAPEGKSTLSAERGASPGDEPSHRVTDDEKPQEGDETHTHEARVDCAAWNVQDENAKHTHGGAVPGAENMTAEGQATEGNLPPRDSDHAPPVDPPTSPRQIVFGSISPEYLRTMWEEEGPEALTNTGVWASKVPATFIAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Q9</accession>
    <name>A0A2G8S9Q9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA-splicing endonuclease subunit SEN34</fullName>
            <ecNumber evidence="3">4.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-splicing endonuclease subunit Sen34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_07199</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">tRNA splicing endonuclease is a heterotetramer composed of TSEN2, TSEN15, TSEN34/LENG5 and TSEN54. tRNA splicing endonuclease complex also contains proteins of the pre-mRNA 3'-end processing machinery such as CLP1, CPSF1, CPSF4 and CSTF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Q9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9Q9"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000002">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="13">
        <location>
            <begin position="162"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL30499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="255" mass="27785" checksum="ABAB81EF1000818B" modified="2018-01-31" version="1">MSGLELAVLIDDPHAHAAPSAEALANWNAERELSARHQIATAEAEKVSEKAAKLSTSEEAIRKRKEREAKRAAAARAKALAEGLAVDDNVPPSLTSASTTPSTEERPATPSKAAALQTFNVTIPASSLQLEWYAPDVAKYTTLDAARQAGVWTYPATPYERAKCRIFRDLWDKGNFMGGGIKFGGDFLVYPGDPLRYHSHFVATVIESPKAPLTPMEIVAHGRLGTATKKSHLFCEWDKDTQQVTYFSVEWAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Z2</accession>
    <name>A0A2G8S9Z2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Postreplication repair E3 ubiquitin-protein ligase rad18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 18">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSI_07264</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 26">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RAD18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Z2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9Z2"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 20" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 20" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="UBZ4-type" evidence="23">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="211"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="379"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PIL30564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="426" mass="46748" checksum="BE3F9E363CB57C3C" modified="2018-01-31" version="1">MASMLDDLLAQGITDSTDFPDDATTPGLRSFDDALRCGICRDFYDAPVSLACGHCFCSACIRSALPEKAQCPTCRKEASESQLRRVVAVESAVHAWKAARDLILRFALEEERRKSRPVLPSLSQTRKSSNGNHSERLGQKRRRRDSPLPPSSDDEIVAIPSSPAPSGSSTPDISSLPDLVECPVCQKDVLSSKINMHLDSSCKKYLFEGSTPTGSNTGAESSKSKQKQQWSHLFPGSKGKNVPAKAKDRDQSKTKTKGKGKGKSRATPDVDVTDESLEHLPKVAYDIHPRQRISEMLAESGLPTHGDKNALARRHARWLVLYNANIDRDPKQRHTLDHLRQELKAEEAEGRTKKETVDDVVAYQKANKGTFAKLTEAARPKKPIKVKKAKEGTPVLDGDEVRDPGLAEGRNSPAGHEVIDVDDSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA07</accession>
    <name>A0A2G8SA07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA07"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA07"/>
    <dbReference type="OrthoDB" id="60204at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044594">
        <property type="term" value="F:17-beta-hydroxysteroid dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078:SF57">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13078">
        <property type="entry name" value="PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peroxisomal multifunctional enzyme type 2-like N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="319" mass="33962" checksum="E7B23A548E4863A8" modified="2018-01-31" version="1">MSQQYDLGSAVGYQEEDQPVSWNQRDLLIYGVGIGAKHNDFAIVNELDKSWSPFPTYPVVLPFKGTNQDVVNFRQLMTGGKRAPGLPKFDPNRGVHGSQSIEILKPLPPVSGPGWKVKKRIVAVSENKSGIILENESTLVDPQGTPYAKLYSGSFNLGAKATGTNYSKRIAGPPQAKQPPKDRKPDWVVHDQTSVAQAVAYRLSGDYNELHINPAIGQAAGFGGVILHGLATFGFAARAIVSAVGGGDPSSLRLFGVRFTAPVKPGDAIETSIWEIGPASAPGHEGETEVAFVTKNVATGKVCLGAGVAYVKKAEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAB8</accession>
    <name>A0A2G8SAB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4100 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAB8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAB8"/>
    <dbReference type="OrthoDB" id="2752673at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025165">
        <property type="entry name" value="DUF4100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13352">
        <property type="entry name" value="DUF4100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4100" evidence="2">
        <location>
            <begin position="314"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="820" mass="89125" checksum="A671C1F9AF8D8371" modified="2018-01-31" version="1">MAASYVMPIPNTAEAPKFDGHYIADFLEDISMHLARVQVTDEDVQIGWILRYCTPAVRDRIRFLPEMDRDTTGKTWAQAKTALLELYGDIDKPKPLPLAEFLKRVQELADKPAYTTKAQVNEFYTQYTSLAQPLLKSNMISDNDFKFHFIQAIPSTMKPAIRVLIPQSNLTRANAPEAKIILGYLRSLADKDDPTYESWRYDESKAQEIMLLQPSASSSQPASSNAPASAAKSLTSDDRMDELVEKMENLRLLFAQGQRPANIPANPGLQQQRPLRCVMCGQAPPTHVIGFRNCPELANLVNEGRVRLDPMTNRYVMSADGSDLPRAPNGHPGGVAAYIRSLTPTPPTTRVAGAAHAAVIFPDGSTFATLTASHIAGSDPKLRSGKEYDASGRYDPKKRPDDKPSARQRAQPPPQPSGSSAPQPGPSTGPAGPSTPMQTPAAPPAPTAPSPSPPVASPPTSAPPVPPINREEGWKQSLPKNKGKEREHDPDVIMKDTAPKPRDKDKSTPTTGYRNMSELESSVDVQCVYETVLGQTAISLPLRDLLGIAPGLLDRIHEATRRKRVPKNQTAQTSVIESDGVPIVVAVPAAASPLRGATLINTDSEDHDQQIAQAFFAGQGSPSVRDRFLAMSVGVLSGTICGIQFRLMIDSGSELNLGDNSVPDRTQLPLDYLGSSWSLRGIQGGPEQLLGYLSNAPIFIGGHEFADHLFISPNDSIGETFSIILGQPFLTHYSARLDYSPSGRSMLYLWTRQDKERGARPTVGIAITLPNDPRNREIPSHSASYVSPYIEEITDEDVISQVFPVRALAASEPASPPSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAU8</accession>
    <name>A0A2G8SAU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_07050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAU8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAU8"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="117"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL30881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="211" mass="23064" checksum="1CF478CD99EEEF60" modified="2018-01-31" version="1">MKVHLSRDGPAPTSHLFIAAMVAGGLGGIAGNPADILLVRMTSDSVRPVEQRYNYSNALTGLTTLVKEEGVHGLFRGMGTNLTRAILMNGSQVGSYDLFKQLLLRNRLPIVDHQMQDGLLLHSVASILAGTVATTITAPADVLRSRLMAAHGETHPLQVLTTALRNEGPRFLFKGWTPAFIRLGPNTVLMFIFFEQLKKGWRTIFPANYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB82</accession>
    <name>A0A2G8SB82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB82"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB82"/>
    <dbReference type="OrthoDB" id="2742110at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="462" mass="51426" checksum="A63F4315D4025C4B" modified="2018-01-31" version="1">MAVPVRRMLAARLGKDLLLQIFYHLDTDASLCAAARVCRAWTLPAQELLYNTLCLGPFDPPARSRLLARTLRTAPRLASMVRCLSLHTGGPDSSVAQAREQEHEQDQDQDQERDQEREDVEWQWLHHLPPHGLARFRYAWASEDAFDPSVLAAPAVRTVPHLVAHGPLTPAALRACLALPRLEALEVDFANAHCSDPYSDLDPYFESQSEWGESGWDWGMDGWGRGTDVDERDWAIDASLAPRLRRLLVRVYFVACPAALALFRAFAPQLEAFQLHALFELFVPHRAWAAALASPPSPSSPLSLGEPFMDAVVRHHRALERVRCPLGAYSDAFFRDLPPSVRVLELYVDADPDPDPDADGESRGRRWFPHARALAGLLRGRRESGLREVRFLSQYRTTVPVGLGSGWDEGEGLVDAAREGGVRLVCVRVPGLYTPVQCMAEADIVESSECETLLAHLGRGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCJ6</accession>
    <name>A0A2G8SCJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCJ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCJ6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41854" checksum="562D262CF2137A6D" modified="2018-01-31" version="1">MSRADPVQLSMPSSYTHPHDDEMEDDAYSVISADSTGSMLYAHSSSSATSHDWEMRSASPAPSVYSMTSSLRAASYVREFGRGINNYSEVYRLPADEEEFERLDRQHIMFMEVMGRYAPPIPEILADDTPGVTKTILDIARDFPHCSAVAVDLVPMQDINMPPNCRSEVDDINLGLQHFYGEFNVAHARLVSSGIRDYKGLIDEMVQTLRPRGLVELVEFDFHMYDEHRQSILSNRLEEETDAVARWMNFVNVAIEQRGGEPDAANHLRQWASAHPDLEEVAYREFWFQSCPWKRPNEHNASRDNRIAAMMRDDILAFLQSGRPLLLGSGLGDDFVTELQMSAERELYEATTRTYVRVQNVYARRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDT6</accession>
    <name>A0A2G8SDT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heparinase II/III-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06442</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDT6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDT6"/>
    <dbReference type="OrthoDB" id="3476529at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="4">
        <location>
            <begin position="518"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="788" mass="85972" checksum="DC0D4642415CC78D" modified="2018-01-31" version="1">MASNYSYNATYNHSNASNIHQPTPYGSGDPYYNESTGFITPPQPKKGTSKWIKIGIPVGILVIAGAVVGIVLGLRAHDKSSTSSTSGSSGNSNSASGSKNNLGLFATATDSQYMLPIYPSTTNTALFTTPTFKASSSSSSGWPSDPFQPANPSVTQVRTDRPRLIAPAYKWAALPSLIAKDPYLKYWNETIFGNATAYYDLPVVQYFMDGDSGILDNAREVKMRVKAFAYVYRMTNDTKWVDRAFKELQNAAGNGTTAFGPDGNDKWNPTHFLDTAEFSAAFGYAYDWLYDILTDEQKSQIRTSLIQYGLSRGVVAYNNSDNRFTGWWSSNIYGNWNCVCNGGLTVGALAILGDDTTGTAEQLLALTVDNAKQNCALAVSPDGSWSETANYWYFGTTGHAEMASSLMTATGSDYGLLDVNPNFQLTGLFHMHITGPGSLFAWGDHGPNKFSTTANGMFLYGDHYSHPEYVLFQRDQHDAPEPWSMFWYNPTVAGAFWDGLAIDHFFTNNTDQWAAMRSSWTDENALYVGIKAGTLQGHQTHNDLDCGDFVLDALGTRWAGDLGSGDYRSTGYFSNDTQESDRWLYYRKRTEGQNTILVNQANQLVTAQPTILQNLTSGTTQGSSTVLSIQKDDTALFTADLTSAYDNVTSFKRGIRLLNGRKQVLLQDDINASGTIMWRMHTNATVAVDGTTATLKIGDKTLTMSILNAPSGVSMTTGEAKRFASDPALPTGMTDQDNPGVTVVMISLPAGSYSLQVLFNPQWDGMSSSDFVTPPSVPIDSWTLTSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDX4</accession>
    <name>A0A2G8SDX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDX4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDX4"/>
    <dbReference type="OrthoDB" id="3264102at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="101" mass="10728" checksum="3E3A3BAB2059D8E5" modified="2018-01-31" version="1">MGSLCSKSGTVTGGHQILGSGPSGSSTTSAAPPRPVDPRRAAAEAAERRQREVGHRKERIASRTRGGSSPQIRMQGGLLLNWKPRNPSLARQNRASPSDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE42</accession>
    <name>A0A2G8SE42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE42"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE42"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="149"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="653" mass="70274" checksum="A62FB4C49F54031C" modified="2018-01-31" version="1">MSRSQGRPVQVVYASWDEVSEALSARLKAIQDNLSDPLVTLTSSQDDRPQPTPGGSRDAFYIILPMLIVLSTFLFLLLLFLICVILLRRRRGIMLRDSDGPIDMSREDLIEGEGGFEGVESRWLETVSEPERRAYQRAKEYQMQYPPNSMPTDITLSQFLSIQEKGVSAWSFEPDFEALSSLLVHARTELTFLPDPASASSVQSNLPLPKLNEVYYWEAKMFDLPETTNVAIGLATKPYPTFRLPGLCRHSVAYHSNGDKSHNYPFTAQACGTTLKEGDVLGVGYRPRSGTVFFTKNGRKMEDAFTGLTAWNLFPTIGADGPCSIHVNLGQSGFVFIEANVKRWGLAPSVGTLAPPPAYGSEVGSILLAAGGEITPIPSGVGSPASPAGGSTRSRRSHRSRRPRTGLSSSAPIESSPLRGNPLTPASPPITPPPPITPIEEEPDSANGEGPSTSRRYFSPTDMPFHTPPNANLPPSPTQRDATPRADDDQSSVTSSRPPSRGPAGAGANQFNVPRPQPFNFTHSRTGSRSSVSGADLAIQVHPPPESPIAADLPTPGPRDIHLQALAPSNPPAASRSAHASADSSVAQLEVLNAEPPAYSPLDAYAYPDGAHIDLPAEVIAAALERGSLPPNVIGTGNLSRSDRHRSRRERRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEM3</accession>
    <name>A0A2G8SEM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06732</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEM3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEM3"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000534">
        <property type="entry name" value="Xyloglucanase Xgh74A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013970373" description="CBM1 domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="10">
        <location>
            <begin position="805"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="767"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL32028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="842" mass="87834" checksum="6C1F5E7B9CA8B3A4" modified="2018-01-31" version="1">MLRPTLLATVSVAAAISLVAAVSSQTYTWKNVKIGGGGGFVPNIVFNPSQKGLAFARTDIGGAYRLNSDDSWTPLLDFVDDARWNYWGVDAIATDPVDPNRLYLATGMYTNSWDPNNGQILISTDQGKTFTPSVLPFKVGGNMPGRGMGERLAIDPNSHNILYFGARSGHGLYKSTDYGATWTQVKKFPSVGTYVADPTDTTGYNNDIMGLAWVTFDSTSGSNGTATPRIFVGVANKGSDNVFVSNDAGSTWTAVAGQNNTFLPHKGALSVAEKSLYISYSDGSGPYDGTSGSVWKYNITAGTWKDVTPVSGSDLYFGFGGVAIDAQRPGTIMVAALNSWWPDGQIFRSTDGGATWTGLWAWQSYPTLNRYYAYDDSLAPWIGPDDTIDTLTMQIGWMMEGLSIDPFDSNHWLYGTGETIYGGHDLLEWDAGTSRNITLKSLADGVEETSVQGLISPPSGPHLISAIGDVDGFVHNDLDTAPQVSFSNPTYSSSSDIDYAGNKPATIARVGTATDGSQGKQIAISSDAGTTWSQDYGAADDVAGGKIALSADGDTILWKTSSNAILRSQYTNAFTTVSSLPSSAVIASDKKNNSIFYGASGSSLYISTDGALTFSAAGSLGSSTSPFRVIVNPNVTGDVWVSTDKGLFHSTDSGSSFSAVSGVTQAWSIALGAPKAFGGYPTIFAAANIGGVGYFRSDDAGVNWVQINDAAHGFGSASANVLAADPRVYGRVYIGTNGRGIFYGDASGAAPAPTATATSTTATTVKTTTASTSSTTTKASSTTASSTTTKASTTTSTAPSSTATGTAPLYGQCGGIGWTGPTVCASGTCVEQNDYYSQCIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEY5</accession>
    <name>A0A2G8SEY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEY5"/>
    <dbReference type="OrthoDB" id="2750860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="183"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="342" mass="37543" checksum="6A4314B3F2FAAD1E" modified="2018-01-31" version="1">MAPLADNTQLHARSGFPLPIIGSVESAFGLVLIGSYASLALYGLFINQTYKYFRMYKAEAPWLKGIVITAIVLETAVTVLHVHLAYYYFVKNYGNPLVFLRGVWSLDIFPVVATCIMINCQSFYTVRILLVGPSKYRLWLVVAIIILMGGALGVSVASTIVGFQGITLNNFSKLLVSLDPWLSAFADVILTATLIYILHHSRTGFKSTDSMINSLILYTISTGLLTTIFNIISFVLVHVYGVKNWVWLGTMMIAERLYSNSLMAALNSRKVTSKKRADADSARPAEVYGTAVRASTLRFNNSSAINEGIELPQVDSDSGVMETTRSVGDVKVHPFPFGDVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF84</accession>
    <name>A0A2G8SF84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF84"/>
    <dbReference type="OrthoDB" id="3064136at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="537" mass="56095" checksum="3E192B8FFF659759" modified="2018-01-31" version="1">MSSDTPLSDILSPQSPTMASAVFGSSPRTRRPSIPHLPSGSVSQQPTSPPHQGKALPPLPEHAQPQSQTQTRSPRSKRKTKTSGGPRGRPDSPDVETMIKRTPRPRRTSSVTFQTNSNSPIGRTRSATGTGMAVPSSWRGPGKRQGLDEDSEDSGMLLDKDASMDEKMLERDGSESDSSIDIHTPLPEDEDAPSLLTRRLIKTNLERQPSVYSTTSRALSQLSKSTSVGNLSRAPSAFSPSPPTTRSLSRSVSSTFSQNRLSGADSDSITSVDLPRPMSRSRTQSNASASSHVSSGSRESSTAAPSVTSSPGAPARTGVPRPLRLPQTAGIQSSKSVTRSTSIVDSRPPVSSATARIAGPPSSPSLPPPRNRTVSNPGSRPGHGHSNVYASGPTRSAAAPAVSRILPPRSLSTSVMAPVRSMSMSTLSPVERSSIASAAAGTDPLSAFPLPPSLATSQSVGGLPRPSSSLAYAQKPASSISGPSPPSSTRPQVGLRPRPRTGTGMIYRNSSYSSFLDTSRASRTSSVMSTGKEVGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF90</accession>
    <name>A0A2G8SF90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF90"/>
    <dbReference type="OrthoDB" id="2756561at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="414" mass="45410" checksum="1E2727BEEE03462C" modified="2018-01-31" version="1">MHAPTRLCLFKFVTSHRTTGDGHEHFSTTHPPVLSSMADPGPPRTPTPTEANPLGSASAARTFTRSASRRALFEGASGEGTPDTTPPPDMNGTGFDDTLSLGNLSSLTSAIDTATAYDDTNIFRMTPSFGTTPTPADLGKYRRIAEQAGLRGDQADAAIAVAQMTPRTARVQVFSTLTQGVNLLTKLRDAHQKNWEIPSKIKNRMHIVVRLALLAPIPHCYKDELPLLVLRILIKDGTLSKDYETRQEQRAKTIMKEVASYAGHVRSDMKNHILGSIKEPSTYVDTLALTTTLSRPCGKDIKLTKELLGAVAYLRGIMSLQAEGRTAVAVGADRDVWWQLLERRSKDSRERHETLDARAKHLQDWVQEDQVAYGSSNPESLAALAPVSTQLQTLVFDAQFKGIEGLEKDILLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFK4</accession>
    <name>A0A2G8SFK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_05257</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SFK4"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000003">
        <property type="entry name" value="Class V chitinase CHIT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF397">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="2 10" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013688182" evidence="13">
        <location>
            <begin position="36"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="122"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="14">
        <location>
            <begin position="161"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="218"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1293"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1300"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL32554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1624" mass="174517" checksum="AE15D78676974B5A" modified="2018-01-31" version="1">MATKPRPTRPNSHRTMVFLLLTCFVLLLLPDSVYPVKSEYLSPAARRFRLERRQTRQNASRARAPSTPNSRLPSRSNAPRSTPYDVDSALHHSRNTRALPLLPRQLDNESCNNITITPPGFDGSCTVLEPCPNGACCGKSGFCGYGSDFCGDGCTSNCNAVAECGPNAAPGHEDCPLNVCCSKFGFCGSTDDFCGANCVGDHCGSPSIPSGVNSPVTSRLIGYYEGVFETMRPMVSRQYPRGRIYSPQLRFRVYRSGTALLTLLVTTFAVVPASASDVPQYKAFTDLKQSNPDLKTYISVGGWSFNDPPTQHVFSDVASTTANSQAFATSLVNFLVTYGFDGVDIDWEYPVACERGGVPADTANMVSMFQIIRSTFSASGHTFGLTFTAPSSYWYLQHFDLLGLLSYADWVNLMSYDLHGVWDAKDVFIGNIVQAHTNLTEIEESIGLFQRVGVPLDRIVLGLGFYGRSFQLTDPACSTPGCSFNGPAPGGPCTGADGTLSFAEIQDILSRNSGATPVYDQTAQVKYLVYDTNNWVSYDDHDTFTAKVNWARGAGFGGLMVWSADQDDFNSTALAAVLGEDPSQIVPRSLDQNSKDGKQCVQPGCGQTCPSGYVQMTDVTDGELANLCNGVCNVGEITLAVDSWGTGAKCSSGHKAFCCQSGLTADEIARATDCQWCIRTAIAQFVLRSCNDNVCPAGTFTKATDYYGDTNIFHACLMQEKSYCCRPPDGTTTTSPFSVDDLFPNPPSNGDLSWDLQDDPIDENAPNGGADANDNSFGLIAMDGPSNLLSSMAVESDWVLVGCTGQTDTMQTVTAYCRKKDNDPASGCSAVFESGAKNTIVKLPSGCGGPYARLHSLEVNNSIALAGLHATKKPADNLVYMAEFDFDFSRMSETRAASDGSVLLRVDATTLPGYWSEIDTADPNSPARRELEERWFGAFGDWLSRLNKVKSNTKADLGMSKSFQSVLYSASQMCASEDGTTMFSSSLTLTASGNAQANVEYGFYLEGTLFPPAINQAYVYVSSHGSATIGLELAGRAAASYNSNKVAIIPPVFWPGLSYPGIVSIGPSLNIYGQLQGSLAVSGNIGASVTYPFPEVHVSLGIVGSDPSQNDRGIESSVETIVATYDVAPTFDVSLSGSLSIHAIPEASLTFDLLPNTPVHVGARAYVALDGAVTLSFAADTSAVDASVVASADVTTGVEATAGPSQYTLGPFNLFHTDLTLYQQSLSFGDTTQVRLAQPAYYDLVEGGVFSRGAVLSGNFTPRPFVPLGQPLDRRSIIGGTLTCPATVDNSGSASCDQQLADDDPADADPDDTTDELFRRSEFIEGLLENRSLEKRVKVIGCTGPSISPPSYRSTTIAGYWYFAQPANPTDVSIVALNQKQQGVSWAREHVYEVQLLTQFMSDVLLPQVFGSNTNTWCTWIKANIFRSVQFAPNIKVQLSSLLAATEPTGNALMPALTAEANSAKQAFISGKRRFRAASTLRNAKLSPGNLVYLIRAAANSIEYMNDNNIRLEFLRVGRLVEQQWVNFLALNGNQLNGVPFNVQQAYRTWVNGLLANYGSNALQFFNDALQALSDKMTAAGGTVQIGVLKDCSSTKVTFDMNQFAALSASVQNLANNGITWTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGG5</accession>
    <name>A0A2G8SGG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGG5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGG5"/>
    <dbReference type="OrthoDB" id="2738900at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="620" mass="69162" checksum="34015929BB47F298" modified="2018-01-31" version="1">MNLGHIDPSTSETIEMTLLQAVAALRRLRNSRRPVNKLPSEILSHIFSFVHHSGDNLDNISYQFGLHTIREPVALLVPLLSVCSRWRSIVTTSSLLWSTIDNRSILDLAISSKYRPVNGPLDVHIVDNFFRPAHVDYDRDPQALPVFLEHNSTLMKVLQNEGHRIRDFFAEIPTVLLPALTDFPGESLRACELWPSPSEHAPDGTGAIRPLFNACTPNLRALVIGNLVFIPSNHFPSLTHLILAGGVGSIPPGRSLFTFMDFMLLLSRCPKLQVLHLSDIDVIALQELPDDRILVPVNLQCLRKFSNEEVLLDQTGGHHLPYLGPQFRRALLTHLELSPDCVVWLATILPDDLEGTLHCLPFDNSFTSVYLGAHDPRQPKTRALNAIEPECFSIMATDPPRQRGVRIDFQMPGRCYSTGLTTELARARVLDAIRSAPLLSEVRELWVVPAANTLLSEPDSLLAGFPNLTTLVLGLMPDPLALVRVVTAINGTETDSELMHMPADWEPLLALEVHDDLAIPCPRLRTVCVYGLTERQAMLLYSVVLSRGEAGCPIRRLVVGFYEPPEDNVLDLVEGLCGLVEDFTLIRHGEQCPDDLLWVHRLPPVCCDSSEHNAYWPAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGX5</accession>
    <name>A0A2G8SGX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGX5"/>
    <dbReference type="OrthoDB" id="2802907at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="122" mass="13516" checksum="31ABD61777E8A270" modified="2018-01-31" version="1">MHTVEMQLPLSSSTTGFCASTKRSDSYGAGTRRSRPQRCCAAIIWMETVLEVLGILAFSAFSALRAYALSNRNRWFAAIVIFLALPPSVIFIIQWLFQHAKTLPSPFNCSASINISPAFTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHG4</accession>
    <name>A0A2G8SHG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHG4"/>
    <dbReference type="OrthoDB" id="3152032at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="129" mass="13940" checksum="555976DF35611D30" modified="2018-01-31" version="1">MLVTAGSQLLAICKILAGIYKGHVGSQVSIISQPHSALSTLRDHLLLARTIPVILQAPSKLSFSTSAPAYAFFPSALSAPNAFALFASTQSPRDTYHMYEDARQTLFPSSERTAQRKTSKSSLKKLFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHT5</accession>
    <name>A0A2G8SHT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHT5"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="528" mass="56872" checksum="D8B1F56EE396AF88" modified="2018-01-31" version="1">MPEYTAFPLLQRLQAILTENPPYCCGILELPPDNFELYYGKEDARYEVEINTSMVRLSSLRQRICRFVNLSKPHDNGALEALAQACKPAKCARGSEDTVPDQASRARARCKAMDPEEFVTRFDVEATGLLDTVRLALLSKDDQKPERALRAELHKLHVHGEHSAGAARDVDGPRALRPYTRKDTPCSQSTAFASLVVVFPTAHSGGALLLRHDDKQFTFDPSALRLLAGRTTRASVAYLAFTSASAVEPALAPVLAGHRVSLTYSLSYVEQEHWHAPPTGSIEVLQPSHANTSALTAALAALLADPAFMPQGGTLGFGLRHRGAYALPKVWTRDVDVDVEDPLDSLKAQLTGSDAALCAACTALGVPPRLRLLCRGPELELGDGDGDGDAIVLDHMEDLGDGVESAAGALLGRGGVRVRSCAFTGDAGDPWVPVRDRECGSGEVPGPERLVVHWVTKPGEKEKDGPRSAYATWGDEAALCWLCTSVCVLVEIGSYGDRSKKLKAEGVDDEDIHVGSAYGDEGELEDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIX7</accession>
    <name>A0A2G8SIX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIX7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIX7"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF382">
        <property type="entry name" value="ACYL-COENZYME A OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="62372" checksum="BC999E3862D07E99" modified="2018-01-31" version="1">MSSEGFPARTLHLLDTELFSRPVYFMDQDERARLSYEKAKAIGLSYDMTIHDILSLTPKFWEMHNEPAAVLDGGAMTLLAIQYNLCAGTIARYSRRRPELVPLVEDLLQYRKHGQFMLTELGHGLDIANMETTATLLPSGEFLLNSPTPSAAKFMPPTVPAGLPCVAVVFARLIVDGEERGHRPFIVPLNDGKHMLLPYRGGTNPLTHSLTTFTNVRIPRSALLGSLEAPASVHANLLDIISRVTVGTIALSCVALPVLKALVTIGTMYSLRRQVGPPARRMPILSFRTQHAPVLAAAADAYVMQALQRWAIERFCDEGLDARVRHGVAAVFKGVIIRHSQQDAVAVSERCGAQGLFCHNQMMCHYNETRGLGIAEGDVLGLAIRLINEILIGRYEMPPPADPNSLLARHEASLLQDLRGVLKSISHHRSTEVNRLILPHCQPVMEAMGHRMAYEAAVVQGVRQCLVDLYVANVVKLDPAWYSEHAGLGQRAQQEMATRAMDEVLPILGELVHEMDMFAYVNAPIVSDESWAEFVGSLKVFGGDAHVDLGLERVGRHADPLVRSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJP2</accession>
    <name>A0A2G8SJP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_03687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJP2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJP2"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL33979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="206" mass="22187" checksum="6CED66070D8D59CC" modified="2018-01-31" version="1">MTRACKGVPWMEVDGRFRHPNAIARLTASTAKIAPPPPPLVPSPRPTSSDRPQALNSLSSHPPPPYLDVLHIFKMSGAAASAGASKFQAFMNHPAGPKTVFFWAPMMKWCLVAAGLKDLSRPADKLSVSQNLALAATGFIWVRYSFVITPVNVSLAAVNFFVGSTGLGQLARIWHYQRTQDDPVARYFGTAGPAMKVKSEATAKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKL6</accession>
    <name>A0A2G8SKL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03079</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKL6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKL6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="7">
        <location>
            <begin position="327"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="54992" checksum="25881251C1DF59BB" modified="2018-01-31" version="1">MGMHANADVPAALGNAPGGILTLIYHACDPADYDAWEEQGATGYFDKISRDGPRVNKNPAVAPISEYGIEAAQNIGIPLSTDFNTSEGSLGAGILHAMIDGKNERSSAATTYLKPNVLARPNLKVAVKCTTERILFAQEGVVPTAVGVVFSQTRDGPKFVVGAKREVILSAGIVGSPHILQLSGVGPADDLKKFQIPVVHDLPSVGQNLCDHFSPGMICFRAKPGKTLDDLVQSPLRAVLAFLQWFTIGTGPMASLGGQVGIFTRSDDETLPYGPHLETLPIKNLKSGPRSPDLETILFPLAITKQGMDVAPPGNYGLTICPVLLKPASRGYIALRSADPYDHPNIDPRYLSDESDLNMSLRSMRLAMNIARTAPLVDHRPRIGPDGPDDLFWPGDADPDAISDDELKRIARMRAMSCLHPQTSSARTGQDPSSSVVDLELRVHGVRGLRVCDASVFPDTVSGHPAIPVIAVAERAADIIDICALPHFCYSTCISPVAPPTVQQPRSLHSTNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL28</accession>
    <name>A0A2G8SL28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL28"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="131" mass="14353" checksum="4AA2B77695E0691A" modified="2018-01-31" version="1">MIPTAPVLSKALRRALTPKRGNKDYYKGTRQAFLPGGHRTGAPGQHVVRGKAKYRLVDEKVRVFVAPPIQDLENSALKAYVSTTVKTSVSKEFNKVLYGGKLPRGGLTGEYFYKVARRVPVVPADPPSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLR8</accession>
    <name>A0A2G8SLR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLR8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLR8"/>
    <dbReference type="OrthoDB" id="2575061at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="856"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1126" mass="121223" checksum="565BA1691686FC28" modified="2018-01-31" version="1">MSRHTHDSPSPSASPSPQSASRPSSSGNTDRSKGPTHGPSPVSERQSSSPQSPQGVSSSSEGYPSWLPKRPPGPAPRSTIHSVAGMFSEAGPSNGNDPEPPATIGRKPTPRSVRIVSLQSQAEKSPRREPTDQSRGFSGAGHARVWSRATSAALTPTLFSASGGGEGQPPRPRFNAPSLNVELLRNPSWKMRLWYHLFPLFVFGHIPLQTFFDFNAVFVLLSVAKFPNPEAPGVPGSGRNWALGAAAYIACWFAWIAVVFVVYELVYSFIRRWRVKRPLILPIYFSSAAFNFAAMSSYVNFSFIYHIRFSAFAGEHGSLSDGLAETFYFYSQNLPTVALLMPRAGLCLALLFAFSSPDPNVLALTDAGISQRDGTFFRSSDGTLTDYARGVLIANAAWTAWRILVLLISWAGLWILSGQGCAGLCGPRYRWEEEDAEKAAAAIHDNVSDFDTLPWSWKECTILRIKDAYDFCLTNKPPRGESALGKEGKGKEVQEAAAPLEGIDRIFAAVGLQATPQPARRGLLSEELFESPRNTPELEDKAAGKARATVPELSSIIPPVAAVQQKERAGADPSGPLMSLPYPFTGFGAQVSSEDVVPFPPSPAIEDKDVATEGEETHHTGEEDEDGEGEEEEEEDEEEDESEVPSSERRTSGSMSSLGRPVVSRYPFQFRRPRGSMSSASHMSPQTHSTPHSTQSQSTQSRSTRHSRSTQSTGNVESSDSHSPRSNTSSNASPHHSSFSGSIIPMPPRHPQAQAGQRRARAGTVPIPPSSPGSPSPVVFPGGRPRARTRTESMVTDPSAERTFGPIPIGSFESDGEGEDEDDHAYEHDLNDESIIEVPEAEGSIEEAERQDSVGLLSAAPSPRASLANLRHRASGLSHRRSNGSRSGSGASVPHSRSRTNSHSRSRTNSGTSLSDAARSRAQSLIQSLGAASRSSIELVRSRANSLVRLADSPYASTSSEAVLSSPENHTFGHPLREQWRAEEGLHEMSDIAESEANIPLPSSSSGEGEGEGEGEGEGEGEGEGEGEEEMGETGTEELEMHTARSALSQQSEVSLATERGGVPVPGPSMTRAQEVAIESRPDLSTAPQSFITAPTTREDTTSSSGRTQRTWGTMDHYPQADWQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMP9</accession>
    <name>A0A2G8SMP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMP9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMP9"/>
    <dbReference type="OrthoDB" id="5283326at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="1">
        <location>
            <begin position="59"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="307" mass="33352" checksum="A346D275FDA2A9DD" modified="2018-01-31" version="1">MLDFDAVLRWLSSKVDVSLPPEFVRALGQSSGIPSPYSQLLGHSHLPTPLWNEGFLHIQPREQVVSVSIDNSSIFLPGGTNPQFGFRRMDIIAANNGEHTNLITQIETNKTVFHVSIQKDETRPLNYTHEYQIVFIEPNDGSHVFGIQLGSPFTDPTGALPAPNAHSFKVLDHALNVLFSTPFTSGAWHNFAVEVDWNARTLAVWYSQDAVLLQQVVSTTLNPTAAAGPDGQGDFHFTVLKSGAAESEVNGVDIQLPLVNPADSPANQADVVHYGIQEGTTEALLYSGVFVENAAQGISRGFGVIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMV2</accession>
    <name>A0A2G8SMV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMV2"/>
    <dbReference type="OrthoDB" id="2758464at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="190" mass="20192" checksum="1DBA5A544A53EC07" modified="2018-01-31" version="1">MSSFIPTPDAAQGDGGHISSKLILTMVGCLLAFVVIVVGFLLVARKSCCAPHPVHANASLPSYHDAQHTHIHTAATRRGCPVASLRDIRQCPDCLKRGDKGEDRSPRISLESLSLPPPPPPPYPPAAHPLPPSRPRGPTSWISRSASFERPPTTIAAPSTFSTPAPPPPPSYHYASRGPVGGPAPRYRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMZ0</accession>
    <name>A0A2G8SMZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMZ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMZ0"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="690"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="762"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="703"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="799" mass="89747" checksum="E61C7EBDFCDDD89D" modified="2018-01-31" version="1">MASMSSLNFYRLHLLTFIIIPLIGSLILWGSNGEFPVNFVDALFICVSAATGTGLVTVDLSSLTVWQQVILVILELVGNQAFVAWAVVIVRRWYFLRHLRHIVAAEMHRTSTRQTQHDTPPYVRHIRETLARFKRERDPSDTLPAQPKPARLRTVRPDMVRRLDIPPQPINPMGSQTHLEDGVVIEASGSDARPRAASRCSHRATGEPLQRPIPPAAADDDFGGFPGIQEIARHISQRLPPQLQQRLQRTLTMPRTETLVPQARRTVITPEGPVKLVSYFSFPVTVKRNSLFHGLKEEHIEELGGVEYRALSALMWIIPAYYIGLLTISFVVVAPYMLLPKWQVNFYPPLQHRPINPVWFSAFQVFGAWANTGMSLVDQSMVPFQTAYPLVIFMVICALAGNTCLPIFLRMFIWLLTKLPGRSRGQESLHFLLDHPRRCTIYLLPSRQTWLLFGIVMLLNCTNLVLDLVFNIGNPATDSLPAGVRVLDAIMNAAACRNAGWQPIPISSLVPATQVLFVIMMYIGIYPIAMSVRATNVYEEKSLGVYEETSEDDDELNDDARWNSSSESRVAIWGRYLMRHARRQLSFGINDFLYMWWLALSLLLLCIIERDNLMNPSKISYFNIFALIFEVVSAYGTVGLSLGIPGLNYSLSGGMHTLSKLVISVVMLRGRHRGLPVALDRAVLMPSEFLTTRSTAPPPEDQLEVHEKNDEHDPRVENESPPVVQQDKDELAELLRLRTRTISLQIPENGPGHTGYVSELRREVSAPSSLAEGLSEDDGFATPNLEGDTTTELEDSAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN55</accession>
    <name>A0A2G8SN55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN55"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN55"/>
    <dbReference type="OrthoDB" id="2745331at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="185"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="351" mass="38663" checksum="EB0E60BA726B35E0" modified="2018-01-31" version="1">MATAPHDLASSLVLASNATVDTFQFPALDNTYGALLLGASFGFMLYGLTVHQTYRYFRLYPTDIPVLRWLVLVILALETAHTAMALTGWYVDEEVEHEAVKGLSNDVDASYYHLVTNYFDPLSLLAGHWSTRLITPLTYANVFMPVAYGMLDGTIDTSWASRFKLSLNDFRHVSWMASAVFGFVVLADMLLSGALIVILWRSRTGLKRTDSTIEVLIVYTINTGLLMIIVGLLGFVFAIILPGNFIYIGISIVGTKLYANSVLAVLNSRRALANKMLVGFEMGSFEPRSVGMRPHTVVETTWDVPQLPLDLPMAESHMSFARPANLASSFDSDTVGTGRGSHTKSFPSHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN70</accession>
    <name>A0A2G8SN70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN70"/>
    <dbReference type="OrthoDB" id="2758570at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="28386" checksum="98644CA4C7245DF5" modified="2018-01-31" version="1">MSDQPWNRLPRTGSVMEVDSSQPRPPVTYALAPLTLVVQAPLNADAMPRKRRRLDSPESEETVGDQRDFGHHSTQDPRWQGPSHPPSDTSGYDSPTEADLHRLAITGPIASGEYYEKWPDTEADGDEPGFTQPAPDPPSPALTEVPLRGDGQSGALASRVFKGKPLAKEDTLMSIDFSHSQDDSTPRSDDALAEKLATMFDQMRQKQRDDMEMFAENIRAQLVVECADLKNEMTRLRAELVDLRIQYQRMQNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNF1</accession>
    <name>A0A2G8SNF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNF1"/>
    <dbReference type="OrthoDB" id="2570975at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="324" mass="35241" checksum="77FBFFBC34BC2798" modified="2018-01-31" version="1">MPSNAGRFRHPHPAYLNGEEPPRAREGRGREAASVDRGEPGKRTRARKPRVPGAIESSENHESRGHALCPPWDRTQRREKSTELARALTGHLNAFSRPSLRFGDNGARSLGFLRAAAKGSMRAAEDPEFLYALFFTRRCGPAVFPDTDMDDVGVGADRVHGGVSSKPSSAPTEGSSSESSMSTSSSVSDVAWHRGRSRPPRERKEGLPGWKEKSAGGRHRGSLGPGEDEETGRAKADDYGGPPNFGLGGCTDILAVRELPHAHPVHRKSSAAADARCKVSPIPVHNLVLAMHCAKWFKLGFWDAWRAPEYMYTLSVAPSPRPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNK1</accession>
    <name>A0A2G8SNK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNK1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNK1"/>
    <dbReference type="OrthoDB" id="548949at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013715141" description="Transporter" evidence="2">
        <location>
            <begin position="23"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="73586" checksum="C0A2BEE373894BF1" modified="2018-01-31" version="1">MASARQAPWLLLLDRLAAHLEAHKSEKSSEKDKKARGKKFVKILEDVCTVVRDAERKVQGTPEFAEVVEKAHGMLNDALRYAYSQAGGFSYIATFAHSEDEPFVEDALEHAGSDILDAFFKVYATLVKPGAPTPRLPAFARVRPWTKSPRPHPLTTRLSRFRGGFAPSATPDLPIAHTIYQARAQLTVDSTIPSIPFDMSLSSCGTILATASGSGWKAREPALHYYLLNDQSASFLEGVTMDPGLSGVPHSVTTDESRNLVFLADDGRIKSFSFAPEASEKVPKRLPNVHTLNTQCGCSGPLAVLPNGRLARAGAGKVAIWNLDALETHQDAPGKLIGEGTLSLDGSPRADPSAVEMSTGTPPDAIVRLASDPSFFPAVWHLHAPSGRLLCGEHAEQSGGYACMSVDLEHGGRRVARYLGHGGEVKRITTSAGDPNLFATAGGDGYARLFDVRRPLPVLTFNTGLQREACNDVVLVHPDGVPTLFTAGDVTQQVKMWDIRAEECVYELATGNNAVTGLAWDDTRSSLYVATECRYINRMGLRTGYRRARMPRWATWAAVEKEYKAYKEAAKKGIVQEEYGGKDYPDVYDAYSYLDDDETEGEEEESDGEEDEADEADVDEAYSADMRWPTKCFHKESFFGYAYDAGEHALLRWHFKDTPDIIQLPASTSADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNW7</accession>
    <name>A0A2G8SNW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02191</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNW7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNW7"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="653" mass="69865" checksum="5CB4527737EDE762" modified="2018-01-31" version="1">MSSSHPTHYSSYSLPAPMQDSVRLPSIKDLNFPPPGQDGAPTNPQGRPEHARPRHEPWSRSSGPSGPVPQPQHSSSMPPPHDPPPKHHQYPPPSKSDPPYAQPAPSPQQPPQVVPTHNGPSAGAPRPENPTDASSKRSRSQQGVSASPGRSPHTVYPPYPPQPPQTAYHQGPPSQVPPPPPPEHLQQPPHYQHPHPPPGYAPYPQPMPRGHYGMPPPPAPSHHQGQPPPSPYPPPAEHWQQPPAQPQPPPPQQFNGYTRTTALVPAPVEARAPAPPVPSPADAERANARHQVIAEILKHCNVLYGFANHYANMTRQQPPTQPAPQEIEEMNYHASTVMRLLEDLRRIEGGEAIPRKEVDYPAAAGNPADEQARPPKRPWEDMARDGEPPAPIVHYDTAGRSSPSPHSHSHPHPHPDEQAQSTAEQDMQIIRNKRQSSTGGAAPGQQKNKYRKRSRATPPGKCHSCNIRETPEWRRGPDGARTLCNACGLHYAKLMRKRDKALDANGKAPPIDLQTLRASTASARGAGSGGGGGGGGGEHGGEPSHSQPHPPPHQGQPPPSPYDQPKQPPMHAGGSAHPGPYQLMPVGASGGPPHAMMPPPHGPGSAPHSATGGPVPPPPWLSSPAGERPGYNAEPPSYVRPSHPPSHARASPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPN1</accession>
    <name>A0A2G8SPN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_02413</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPN1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPN1"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL35683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="411" mass="43933" checksum="FEF47B593E26A6E0" modified="2018-01-31" version="1">MFRFSFDIDDAEDSGFGPVVGPDTAPAQTEQGQLENSYTVAEHSASQVSLDDLLSSLPHTISFSPLSISRPSGHDVVLSRRDLFDARFQLISADHGAGMETRPSEVEFIDAPSDLVPGVYEGGLKTWECSLDLVACLSSIYGSQIAKALQRKRILELGCGTAAPSLYLIHSIFSAEPSTDARVQVHLQDYNELVLRLVTLPNIILSWYMSPASSKYRSSSPAGGSESNDDDEPAPLPPADLSQPGELALTPELKTAFLESLQAHGIHLKLFSGSWSTFDVERAGGPYDVLLTSETIYRTASLGSLVDLMRRATAPTTQAGSSASLEDSASRLSLSDSEDLKVLAGAPYLCLVAAKLVYFGVGGGANEFIEAVENSTAGLGPGGERSSSQVQTVWETNKGVKRSIMRVVWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQA1</accession>
    <name>A0A2G8SQA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_01582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQA1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQA1"/>
    <dbReference type="OrthoDB" id="2777056at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048411">
        <property type="entry name" value="Htt_N_HEAT_rpt-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20926">
        <property type="entry name" value="Htt_N-HEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="8">
        <location>
            <begin position="200"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="419" mass="46373" checksum="F99046FC3917D72C" modified="2018-01-31" version="1">MEVQLVDGMLFAFQEQMTEDPVLLNAFGTIMNALGIRARPYLTQIVSTILWRVNNKSAKVRQQAADLVTRIAVVIQQCGEDMLLNKLGLVLFEQLGEEYPDTLGSIISALGAVINAIGMTRSNPPVKDLLPRLTPILRNHHEKVQEATINLVGRIADRGAEFVPAREWMRICFELLSLVKAHKKAIRRAAANTFGYIAKSVGPADVIQILLTNLRVQDRQSRVLSAIAIAIVAESCGPFTCIPAILNEYRTAELNVRTGCLKTLTFVFEYIGPQAAFYADSVVTLLEDALTERDAVHRQTASTIVRRLAVSVAGLGREDTMVHLMNLVWPNCFETAPHVVREVMAALEAMRVALGPGVVLSYVLQGLFHPARRVREVYWRVYNALYVGAADALVPFYPDAGALSEGRNVFDRCCIQVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQY8</accession>
    <name>A0A2G8SQY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQY8"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="324" mass="36163" checksum="A562C8D6056D58A9" modified="2018-01-31" version="1">MVMSRSPTLRLRDGSEMPQIGMGTWKHYGTKAADAVYAGLQNGYRLVDGACDYGNEKECGDGLQRAIGEGIVERADVWVVSKLWNTFHRKEHVAEAVKRSLADWGVSYFDIYYVHFPISLAYVSPEVHYPPGWYFDGKSEVKHDSVPLRETWEALEELVDAGLIRHLGVSNVCSALLMDLFKYARIKPSVLQIEIHPYNTQARAVEYAQSQGLAVTAYSSFGPLGFRELSSPKALRTPPLFTHPAVISVAQKHDATPAQIILRWATQRDLAVIPKSNTPEMMRENLQSASFNLTEEEMGVISGLDVGLRFNDPADDFAGCYIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSD6</accession>
    <name>A0A2G8SSD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSD6"/>
    <dbReference type="OrthoDB" id="2637024at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="16287" checksum="460C125C26E805B2" modified="2018-01-31" version="1">MTSSNLLPSDTSRLPSYRSTHVGRFHPYPRGGPRRREDALMQTVDHRTADHVTGLPTIPEEPEPEPVRLRPLVVCQEVPDGDVSSLELDCPVVGDVSFFEQQGVRAEDDVGEKVKVAVAHLFVAIRRRSLALLAVMDLLKGEHRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSF0</accession>
    <name>A0A2G8SSF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSF0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSF0"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013425488" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="494" mass="54771" checksum="8D4B33D0C45FFBA0" modified="2018-01-31" version="1">MFSSLATWTVVALAALVCSQQVAFDVAASVGTHPVSAGTFSQPKGNFSTRSLASITSEDQYLALGHPRFPAHQVRVKKSSFCDPTVNVFTGYLDVGYGAKHLFFYFFESRRDPDSDDVMMWINGGPGCSSAMGLLMELGPCNIDMQNASNNGTTWNPYSWNAEANVFFLDQPVGVGFSYADYGETIETTEDAAKNVHAFLTIFFETFSQFKGRPLHLAGESYGGRYLPAFASYVYDQNTVALAEGRDTLNMTSVIIGNGIVDIMMVYRGRYEIECGTAAFDVPFQSISNCVHMKTALPRCQTAMQQNCVDIFDEIGCRAAIDFCQNEVSGAFERSGRNFYDVSKPCLGTLCYLESAVIKDYLDQPSVRELLGVETPKNFSSCDSGVGRAFNQRLDKYTVPSQFYIAGLLERGVRMLIYSGTYDWQCGWYASKLWLEKLEWTGNAWYNLQDFRDWTVEGHKAGEVKSSGPLTFATIRGAGHMISLQACLAWVMMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST38</accession>
    <name>A0A2G8ST38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST38"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST38"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="7">
        <location>
            <begin position="401"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="748"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="748"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="776" mass="88152" checksum="5A4C336A53B4F0A3" modified="2018-01-31" version="1">MAPRRRQQFTQESIDQQLQQIHLLDQASSSENLEQLGPIIKQIHANRQQEAYLRTLQSLIESKDSEIESICGDNYQEFISSVSTLFSIKSYTTNLREKITSLDQNVSQVGKSLVEKKKALLQTKKTAANLDEAIDGLQACLRILDVVNRVGEMIKEGKYWSALRSLEDIESMPPTSLSTTPLFQHLLSSLPSLRGQIKDAVTASVKQWLLDIRNVSATIGSLALEAMEMRTRRWRSRREKDPMLKSSRVGSAVESITYEKTEYNVLDNDQLQVDFKPLYECIHIYSALDSLDEIRRSYQADRKAQSDLIIPEPLPLSSLHSITQEIVGYFIIETHVLNTTGSFRSEREVEDLWDALISRLSAAVEDILRNENDPDTYLKVKEALLGFVMTLESYSYTTTSIHQLILRLFEKYVSILEIKFGKRFQSIIAQDDFQPMYVEKESEKDSVMETVWLTREQRDQLRKSTAPLNLPWSQGFYLCCQDIRSFVHNFYQFIEGVAQHHRNIDDLLSKSLDAILTTSISESIANRVQTIANVSQIAQVITNLEHFEISCSELERSLTNIRSSQRGGTIRVKAAGSFIATRTKAIARITEAMSSKLEDFGLSEYDWTAPHRADSPSMYLYELVNWLTTVIDSLALKDTYKEEAYRGAVSYIASCFLDFLTGRDIPMMNENAIANLLLDVDFLDEELKRNNHSHGAAFAELRSMTSVIMSDAVSAYLVASIRQTSYPAVKPKRLAALLEKLARCGLESRDAGSRERGEKRRKEAEAVGRLFPGESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STG3</accession>
    <name>A0A2G8STG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8STG3"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="244"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="561"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="580" mass="62944" checksum="0ACE30CE68B9A2BA" modified="2018-01-31" version="1">MAEKDASARLRRAVKENNLFLVKRLIKRTDMRNPDPYHKRYTSLAWAAILGHEETFEFLLTSGHDDHEYNHEYSKDSENNTILILLAEARPPPSYPQSNGSSEQDFLGATLRMARMYIDRYPDILDWANMEGKTALHVAALKGNEELVRMLCDHGADFDLADNEGNTPLHYASAWGNVTIVQLLIERGCQYSARNNQGFTPSDYAYSISTRDALQDTARIQFENNKKARRNVFQQAAARGNEWNGVANMQVYPPSPRDHSHGMNGSVRMRSGSGTSHTTTTSNSGDLLEGYPPQQSSSRFWSSPSRRPAPLPSGSHSPGQPSASSTSSTFGFATSPVSQPGSATLLPSGNSNPASALSPIATRMRERDADAMEKYKLRQRSGSATTASTDNPSQSDSTSPPPAPPPKDTDDISALSSIGTIGSVAPRRRLRPSASAAQLRTNPQPLSVPPSQGEPRSRSGTSPAMLKPASNFSSPPSESSALPTPTQNSTTRAGGTPRSGSVQHGIPGIEYIGPPSDYARFPPPPMTEEPERSMTPTTATVPTHSRRLPFNLLLSHKTSMDSHVSSSGHRRNASVNAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STR6</accession>
    <name>A0A2G8STR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STR6"/>
    <dbReference type="OrthoDB" id="3232130at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="277" mass="31244" checksum="C00BC9F76117006E" modified="2018-01-31" version="1">MTLWDYLPQRDGSTSSSSAVSQSSVTAPHVEEKTSRNALRTVLVFSAILIPCAAIPYVLLRRQCLGMVKEITILRVANESFARETRQFTTADAANTQKSVEDILKVVREHNVQLKANATALAEAKESLEAARMRMDELQEKVEDAEKSVLTKLLSIERTLTKAGRVEVEHIKMRTKWQEEMKLQLANLTAETTKWRSAVAEDVRDTGMSLANLAGFVEEVERREGWVELPNDGRGIERMRRLAKRLGERGQPESASLWKEKDDQADVDEESEPRPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU24</accession>
    <name>A0A2G8SU24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU24"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU24"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="538"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL37279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="866" mass="93988" checksum="91BC8A4C27A91EA5" modified="2018-01-31" version="1">MSSEQDWDDLLRNHPIFSLPKGGARSAGRVEAALNLSLSSLPDFVDLDPAEDKPTPCGRRQAIVVKDADLIAAVGSEIRITSLGDSKGARNTSQKTYKILHTPSVQFEIHQIALNPNGRLLAIAGAFQVAVIVLPRTGYNKLVTATVECKEYDISEDADEPQQTLSFFPEKKKGSSFLADDGGEREAISFALGKGRADWGPLTVYAVMRSGDIYAISPYMPKNASIPSSYVHALECYVSAKLEFLSTSTTGKSSSSDSLTTLYDYQRKYVNALLKQLPPGTAWPATARLVSMHPPTTIKNPCARQGPFLLQPAPRNLEASEGGDATDIVYMSFGDDAAEESEGETERLGLILVAFQDGKVDVYLDVEKVEARWENKQHPSTDLPMLAVYESIDLGIVSSLKKSSSNVGQSLLDLIQGNHPSFLLDPIHDDNLYVYHAFGAHVLNVGALLKSLASVLRDSNESEANSSSGMEVGLETVKSTDVQPVLLTFSTEHKSSTPVVGVAIPNDVYLTYSIFVLTSSMRMSVFPLNLRSETSLVSESPPAHSAKPSATKPPQASGSLFKGSQSSPSLFGSPAPPTKLASSTASGSVSVPALALPAPPDTPPAYVSLLSSQPWKTPDVIARPSGLPSIPRLSLPNGSALIDDHVEPETLRFLATTVEKLSAQIHDIQLTHGAAEARTALQEQEFKRQREACAKMLATVKALGGPRQRAAQDRIALARETQKALVEGLERVLQGLMVKASPELSESESRWFEELRRMKAEVVGAGKYDDQALLARTKLLRREVDRLLPHLKEMKEKEMARRENRETLGLSQAFELGKRSTEERARISRMETEIVKLAQRMDISIGRPPTQQQASPKGDAKGDGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU59</accession>
    <name>A0A2G8SU59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU59"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU59"/>
    <dbReference type="OrthoDB" id="3246510at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="91"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="284"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="418"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="567"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="921" mass="102956" checksum="2F522FF53E0AD6D0" modified="2018-01-31" version="1">MDVPDTPRLRVFSERRPAKSLRQRLDTDPFQEPSPQDPVAFAVDLGEAYFPTQHDQVAPRTHSRSASVLSSVRGRPEDDISSIMMRGATDLRNAKFEVEELRREIAFLQARVDSVVKEKDDLVQRLKAVKDAAKQSLQASSKSLEALRTALDDLKTRSEESFGVTRDIRTSLTDVQDLRNSVTETMNRIQPYLEPNEGWAKSTEVKNLMNALELECSRSQQVADLLRDRLQSTGGELVEAKSRILELETAQAHDLAALGRANDTIRGTMEELSSLAICLKNQREEQYEALAAAAEAEAKLASAQEKIEELGGNIRQKDTELILLHTAQTENVRLNEIIAEKDRYIITLRELQPELERLKDVISKEEARSAGLTVLSSEKESQVLALTARTAVLEAENTDMKVKVQDLRSQLDAIDAGRQATSNENKRLRTEKQVLEDKVHNLESTLTSARQELDICLQKLQKANMHCQALEERFEDQSVTLRLTRESAGDAQERLLGAESTYAKALAETTAKLELEISILREQKLGSQATMDVLNASLKRQEASTLAMQEEHANRLKQQELAFAARLEIEDKRLVQLTNDLKDARSRIALADDRNQSLEVEIQGLREQLNQARLPSPESEAELGRLRTRISTLENAEMESIVRAKTLDARYRVGDLSEEEKTFIATLIKTSQTIHEQELVANRNELRRRDNVLKEMRSKVHLLETTLAKHLSEKAKPAPEPAADHSMIDPASWMSSGQSSSPLQAPDRDGQQRTNVDIPIPVRSTPKSNQGERHATPSNDAFALVAPARDLVGESPSAKETRKTSAVPSVARQNKPRFGRLATDCSDEILGFDDEISTVQKATPPSFLSKRKKSDSPPKPVGEPMAPRPYKRLVEVRRAEDPDGGSEDDSGRLEEVTPAEWFQEQGSEATLNLAITRSYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU95</accession>
    <name>A0A2G8SU95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01017</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU95"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU95"/>
    <dbReference type="OrthoDB" id="3251949at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="155"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="382" mass="41809" checksum="F047BBC476A5D9D9" modified="2018-01-31" version="1">MAPYVSTGVVYSSSTADASGRPDPAIAGPVLIQAFMQYLFQGVIITQTVKFYERCRDDPMTLRLYVFLLLLLSILQTMIMSYKAWVATIEVMQWATSENIWILFSLAILCLVSLVAAIILTVKIGTTIVPNLQESHPDPLHASAFAYPLWVYSSLCTAIALTIILSHSLWKTKTGLTHLDHTVETIIFLTWETALLPSICMLTSAIIFSIRDAQGSGTSVAARSHLDLFFALLTGKLYALGILRTLNSRTLLRERLQSIPLGRQSLSRWEWAEPRENFRTSQEGADASEEGDTVGGGSDESRKGPQPTPTTTTVDVTEFDTLPAVAAPIVVMQPSPEGVDPIVGNGSGIDPFSLPPLRQSIPIQRRMSAARDPPSPEPHRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV76</accession>
    <name>A0A2G8SV76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="10">PPIase</shortName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_01182</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV76"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV76"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01921">
        <property type="entry name" value="cyclophilin_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000015">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035538">
        <property type="entry name" value="Cyclophilin_PPIL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="6"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="246"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL37488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="321" mass="35984" checksum="32EFDB5AB52E5FF7" modified="2018-01-31" version="1">MSVLFETSLGDLVIDLETDTCPKTCENFLKLCKAYYYNLNAFFNVSKDFLAQVGDPSATGSGGESIWSLVASQNGPPAPRYFTPEFVPRFKHRQRGTVSMAVAPAVGDEHKGGCGSQFFITLGDNIEYLDGKHAVFGHVVEGLETLDKLNDVFVDQDGRPLKDIRIRHVEILEDPFEDPAGLVIPDAPPVKPPDNSTRIAEDEDPLETMPEEEAEEIRRKKAAQASALTLEMVGDLPFANVRPPENVLFVCKLNPVTRDEDLELIFSRFGTIMSCQVIRDKKTGDSLQYAFIEFDKREDAEQAYFKMQNVLVDDRRIWVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVA6</accession>
    <name>A0A2G8SVA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVA6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SVA6"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="40139" checksum="18B5C00DAC1462A0" modified="2018-01-31" version="1">MATATKKTTYATEAAGHREYKYSQEISQMMFVFGEVQDPNPETVNLVEDIVRSQLIELILQARALASRRGARHLSAEDLIFLIRHDRAKVNRLRTYLSWKDVRKHAKDSDGGGGGGVEVEQLEDGADDKLTAKAQKITIKLPWEIMTMFSDVLPTDDEEDEDDIEAHEASIQRLKEADDATRQMTREEYQHYSDCRQASFTYRKAKRFKEFLNLPSSLDFKTGDDTVDIVGFLAFEMVRALTIAGLEVKKSLEDAYMRDAPHGSGSSPVLGKRKAHHGLGGGADSKRMRREESPEHDADQPLPVCALFAPPPEARTALRPEHIQDAFARMQGDWAQRRSAGMRNHRGGLVRTTVSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLP2</accession>
    <name>A0A2G8RLP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLP2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="171" mass="18836" checksum="CE0172CFC0C497A6" modified="2018-01-31" version="1">MATKRCYFCWVGRQETAGVGRRFAVRLDMNMLAGRRNCRALGSYTSTGGITSSESASDLVLASSPTASFGSTSLSLRYRSDERLSLLALVDLHDMDRQSRATPSLPVLVQVVLSILQREPAFRKGRTGPNPNVDGGCDRVGAIVQDERVVGRKRRFGWRGHGLEDKFTRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMM8</accession>
    <name>A0A2G8RMM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein root UVB sensitive/RUS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_15454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMM8"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="48"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="508" mass="54522" checksum="2CA5D8A72D8AB733" modified="2018-01-31" version="1">MSTRSAFVVREKDVSGHLTSLYTDGDKVASRVDESNKNREVPVRLHTATRSWRQFLGEVFLPEGYPATVSEDYLEYQIYNALQAFCSSLASLFASRAVLQGHGVGDASASATNAILLTVLQDVCSRLTTIVGGYYLGTSLTPEAKTYRLLADILNDAAIISDTLSPYLAFVTLSAQYPFVKPGTNSSLRVVALCLSGAFRALCGAVAGGSKAALTVHFATDGHRPGDVGDLSAKDGSKETVLALLGMLCGSVVVHYVHSAQATYAVLFGLIFFHLAFNAMAVRVISMRYFNRQRASIAWRQYRSTLDSKGRPTPKTGVPTYAVVSHHEKIFTDSSWIDCGGTLPARVTLGATFALLRHPKAASESWLYGFKTRPRSRHDALSDAEVVALLRAFADEKYILTIAPASPARPLHVLVSFKEGHSARDHLKAWAHAHEVAWMCGGKTPAEFEARLGAVGAALESVARIFPGFVDAAKAAGWKVDEGALVGGSPVALSVELVERGGKSRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMS0</accession>
    <name>A0A2G8RMS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMS0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="151" mass="16701" checksum="663052D7F292CAA2" modified="2018-01-31" version="1">MVLPSVRCQTAAGHRSSSMTVLAGSRALVRVTRIPQPSRVPFRLRPNRTSSPPLLWPPLPAPPPHRQLATNCGLIRFRAPRTTQREPRVVASLFTLASRRARSPWQRAAMYHPHAVVVPILASASRLFNVEPPFIIRTYALGAPKGLPTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMX0</accession>
    <name>A0A2G8RMX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="6" type="ORF">GSI_15558</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMX0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMX0"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL22862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="327" mass="36158" checksum="6FEF1A08385C3D6D" modified="2018-01-31" version="1">MQRTLRFSNPRPVLSKTRPHRPSSLVAARCLHQSPSPAQASTSTASGTTSTSTSTSTDTGTDRTTHFGFQTVPEDAKESLVRTVFDSVASSYDLMNDAMSLGVHRLWKDDFVARLRPGARGPLRCIDVAGGTGDIALRLLDFARERYADRETAVDVVDINGEMLKEGFKRFKKTMYHNTPQVAFKEANAQEMPEAEFPSNTYDLYTIAFGIRNCTSIPDVLKEAYRVLKPGGTFACLEFSQVNNPLFRTVYDQYSFSVIPMLGTILAGDRASYQYLVESIRKFPPQPEFAKMIQDAGFTTGALHEGKGGAWTDLWDGIACIHTGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMZ2</accession>
    <name>A0A2G8RMZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMZ2"/>
    <dbReference type="OrthoDB" id="2757830at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="482" mass="53251" checksum="3290049363E136D6" modified="2018-01-31" version="1">MAHSTRKTLLKMMRASRDLHRGGIKHLLRKSPDLEDERTFRSFLRFCDAGGQVAEIAYRMNYLRGLTIDMDPDSFDYDSDDADMWQDELGSMAQALTQLFTSTIRVYAHNFTRLVILSCDSLFAADPNLSLAIASLTTLTHLNFCDATENSFKLLGSLQSCLVAAHIGMDINLIDPLDGDLTALLRRSESSLTNLSLYHTSSPTGVACYPQVHTLDVRHLDIPATRHYVTTFPNLRVLTADECIGRYSGDEEEWARYRNLNIAQQARDGSWGSLQSYAGSILLLYLFGLACHVPYVHVHANDEYESMIIRQVRAVVADTRPEHLVVSQVSHVLEQAEDIVALFNDAGFQAVKTFVLSMSLCAGDYKADMEAMLECIFAAVSSSSSLVGLSLAINWSAIRRQIQTTRPRVGPSGKKQRPKPSRALAFLESLDAHTVADRLLGSCQSLQAVKVVLGKATAERGPVDILCNRKTFKGPGAARGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN38</accession>
    <name>A0A2G8RN38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN38"/>
    <dbReference type="OrthoDB" id="3466517at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="38444" checksum="9F915655B7B053D2" modified="2018-01-31" version="1">MPTAPVDQHGSVLYYEDSGVPGTSTDYVTLVLVHGTCFHSEQHNLRLVLLNLRGYPGSTPYSEEELKCFEGSAEEAESAVRARGLEVAAFLRWFIEAEKIPEFQDTSGSDSGVGGLSLLSWSGGNCQTLSMFANADTLPEDTRNVLNGYLRSFIISQPHCGRNTGPPGMGTAFFNPSLSPEEQALRFALAVSSYYPPFTLPDKIDGDTATYAPRVPLQDPKYVPTTVKLTEAELRGLVYPAIFQRVQPAMWSPALPLVYQSNASRALCDCRLLDGGSGPKKVWPGVKVHLVWCDMTGGDAAWAASVFNCKYKEADPAARRPMEVHKVEGANHFIHWEEPQRFIELLAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNU4</accession>
    <name>A0A2G8RNU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_14480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNU4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNU4"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="278"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL23171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="391" mass="40790" checksum="C5A9142CF8A217E1" modified="2018-01-31" version="1">MSAEQSKASSSASSSPHEAPQPPPPVAHYAPAPYGGHYPPPGPYPPMYAYPVPDPAHHDPNNPNGASPQPVAPFFMAMPPPPPGMVYAYTVPPPAPGYPFAPGMPAPQPPPKPKRKQVKMACTNCASACKRCDEARPCERCLKYGLAETCIDGVRKERKKGIKRGPYKRKNRAGSGEAGADQSEGTEAPSEQPAAVPPPPPGYPIPAEGYPFPYVYPPMSYVPAPPDGQQHTEGANGAPPAMPHPFYPPYPLYPHAYGYPGAPPMAYPPIIPAPVATSPNGTAKPDSTSAPPSANGASASSDPVKGKKRSKAKNGDEGGRAFKKAKDASQGDVQQQHSLPNGDADVAKEHPASQAQQPPPPPYTSHVEPATGPGPVPAFGGPEPRPLMAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNW0</accession>
    <name>A0A2G8RNW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNW0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNW0"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="713" mass="79023" checksum="4063964EC1ECA703" modified="2018-01-31" version="1">MATLQYPNFPRANVLVFGSNVVQALLPSTLISQADALLLAHRLEDVADLAEQQRKKLQSVLNVERHEADELRYVNQRLGFQCFTETLFEDAGNRLYEGELDPRILVSYYPELRGNLFSEDDTVDIMAGVAEYMPQEDSVDDIIRNYSPHLEPNTREAPPAVELRNILSMAARDMLEGYLRKWRRKLAVDAGAPNVQALRTVVDTVLAKLHVSAGKLPGLNGLIDQPNSILLSEIEPVLVKSRHIGVLTKLYRQHSDETKLLDAWAKLVDGEWTDPDVQDPLARIFDMLSEKKDRVLIQKWVGWLVKKDSERALKLLLSTMASKRKAEDDRALLQQIREASPAAGEQLLEHLVVQRRSTDSDLHSQLAATYIDQLLSCLADESISKLWRAKGMSTNDTPFISYFSSTTPDSESKRTRLKTILFLQGSTLYDPVTVRTRLDDHTKILKLELAILEGKLGNHRSALSILVHDLNDSTSAEAYCTLGGEVVPAKTAQQIGERSSLQPWAALVIPLAAPGKQGRGPPPAKRTKTVDDAVKKDLVMVLLEVYMSGGEATADRTAKLLNSQAMNLDVLDVVAKLPAEWPLRVLSTFVSRSLRRTLHARHEGQIVKAISQGQNLAVAESTWAVIREQGMVIEEPLSGDEGEEEEEVEKLGLELGERVEGEPASFNEKVERHHEVTFADDGQRNGGVGPGESVVDISVSPPSHPGMGYNVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNX9</accession>
    <name>A0A2G8RNX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNX9"/>
    <dbReference type="OrthoDB" id="10607687at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="214" mass="22732" checksum="3178250F6B160D43" modified="2018-01-31" version="1">MPLPSHEEETYMLLPSQASARLPIVPTQFPNVYATQPASVFDGPVVVMPVSHYLGLLGMSGTSPVGPPPALPAASPHQYSSTTSAQPSATLAADPRASHSTRQPTAELTTPIDEHATSPSPRRKVNIACNNCHESRKPRKRRAQPPRKPTGSNIAPSSSTASSLNVSLPRPAAQQHMPLGSSSMLSFLPSTAHHLNSSATNESVFDSSYFYSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPB3</accession>
    <name>A0A2G8RPB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPB3"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="341" mass="36570" checksum="EED46F05776C6997" modified="2018-01-31" version="1">MLSNDVAALLGFGCEAALWGSYTVLFMASSVLWLRRFKAPRRKLNVSIFLANCLLYASCTTHFALEFNHFYLILNATGVDHFADETMPLLGADILISFCDLLGDLILLYRCWVIWDKNHWVVAFPLVTATAGFGCIMGVAHLVLTIDPTSPVPPAALVPLGLAGYALPLATNCMATALIAGRLYASAHSAEKRVGALMSGTMRAAQRAVEIIVESGALYLAVQLVFVVLFAMGHPAQAILAVVAVQIYGIAPTLIVIRVALGMSSDHTTPFINHSATQIAIESEGTGAQGRATFLPAILPMRMTDTDTTDDTGRTMGTQRSSDFMELKRFDSDLGGLAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPF0</accession>
    <name>A0A2G8RPF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPF0"/>
    <dbReference type="OrthoDB" id="2747445at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="152" mass="16607" checksum="831F6FF493536AC9" modified="2018-01-31" version="1">MVVGMATVAAGLGAFWMLQFRGQNRNPAEMSTWHHRHTQQVAAANDQVDTPCSGTKITPREPLQPQAIRDMPAADGPGTAAAGRQGSSQPPSLSPAREDRSILASILTFIRGDPKDRSRDGYVGQPAQVRKLNDRGGVYTKNSEYKDSYRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQA2</accession>
    <name>A0A2G8RQA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSI_13443</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQA2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQA2"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="22">
        <location>
            <begin position="246"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="501"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="641"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PIL23694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="712" mass="80287" checksum="0BC04EED34E985A2" modified="2018-01-31" version="1">MARSRRRTGRAQKTPDPTAAADDDTQTQAVEEGEERGQQKRVDTCPACKDDSEQTPPSADKEQWVRCDACKTWFHWRCAGQGDLDAVDKWFCKPCLGMDPSRVITMKPPARKSARKKLQRDYAGLHSGQESDPNRWLRMMEGKPIKKDPFKRMKGSDVGIEWLENDENAMKEPVLIEEETGLGMKMPPPEFTVDDVAEALGHDHPVEVIDVATQSNIPHWNLGKWLEYWNTDPAKRDKIRNVISLEISGSELADKVLPPRLVRELDWVEKFWPSTKKGRGHAYPKVQLYCLMGVGGAWTDWHIDFAGSSVYYHILHGQKVFYFIRPTPANLAAYERWSGTEIQNHSWLGDMCDEVFKVELMAGNTMIIPTGWIHAVYTPTDTLVFGGNFLHSYNVPMELKVREIENATHVPKKFRFPFFTKLCWYTAEKYLRDLKGKEEFPPRILEGIEALADFLVFEARTIERGTESAKRQAKEDVPGDRIKDAPALARELRWRVRHAAGYSSDDDGRSNRKTKTPAMNGEANGIGGKRKRGGGDSVDEGSDLFRNFKRRSWDWEQERPTERDSRVTRAPKPRSQDKSQEWMQTWADGTEGAAEGDDGNEAQVERRRDVIVKVRRTAKGIERQKVERVLEEWVWAGGTSATLPPGMPARTEPEDVAMTEGGAPSGATKPEPVVVEDAKDSAADAPASTQVPNAAHDASNGDGMTKVAVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQH2</accession>
    <name>A0A2G8RQH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQH2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQH2"/>
    <dbReference type="OrthoDB" id="3230904at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="724"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="819"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1150"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1258"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1272" mass="130586" checksum="74D949A1D154706D" modified="2018-01-31" version="1">MPPYLLSRDSPRAQHGRRRPPRAQLARSGSLIGALKNIVSAPLAWFTSYDDQENLSGKRGRTATNAILEDEGTYHEDQPSAKRKRVDSPEPPVPLSQLAPRSIKGYLDVPDDLLSRPTGSRNRSGAQPGHGRSSSMVAPLSIPAVQGAHPARRTASPAGILAPGQLIAAQRTQSMDPPQYRALSLSRDVSMEDGQLGSATRDVTMSPSRRDPFQLRARNSLTPQPTGQAFGPNVRHKERDTSEPPPLAALMSKPQFVKPPLQTAPGQAGQDFTTLGSLAEAKGRVSRSPMRQHSGLFLGARPGTISESDSSYSIPINAAEKALIDLDVYKTPLLPSRLHGAGALPDMFKPKKSHAPVLMRSDSDRAHKPRLGTAEKKGKKKEKVEEIAPKPYAGRGGMKKMLARRKREEQVELEKERENAIEEDQDEVAQLVAEKGTIQATEETPRLPSPPAAPAPSSRPVGGREQSSLRVGRTRTSRNHIARPVSKAKNRFSAAFDEDEGEEANEESREEEPKKLPTLFESPKGFTFAQDKAPVLHDSSNAKEPPISALPFSFGKPTAAPSAAPSGLAQPFSFAQPPKMPPQAPESAQVTNGNLTVKASEPAPVTPAKTVPSVPSISLIPPSPAPAKPAVDAAAVKDATTSTSIPNFFASSSVFSKSGVTIGPPAPSPAPVVQSKEEAKPAALPSLFGGLPSFAPSATAKETSATTTEPPKVMTALAFSFASPASTPAPAPATSTPAPSSGFSFASIGQVKDTTTAQPTPSLFSNSVPTKEAAPQTKAPATASSPFSFGTSVIKVADTSTAPTSLPFSFGTPVVKPATTAAPATSPSPAPFTFGQTKPEAAKAPEVKPLLGASEPAKPSLFGPPPVSSSSPFGASQATGVTEAPKPAFSFGTPPPSTPAPTVEAPKPLFPSASTGGTGGFTFASTAPSAASPATPAKTPFSFGVAPATPPVTTPVDNKPAFSFGASTTPTVSAPTTLFGGPSTGSNGGDVPKPFTFGSCAPARPITPPQKEQEMRMEESPTRGGGMDINGEVKPSTGFAFGTSSASASGPFGQPSQTSSGPFAFGKTETKLEVKPVPTFGGFGQGATSSPFAFGSKPAEGVQSPISPAPFGSSAPFGQAASTPTSTSPFTFGAPSGGASGGFGQPSTGIGSQPASPSTFGQPSSNPFTFGVTPTSATTPSNPFAFGSQPASPANGNTGLPQPPGSSGGPAFTFGAQSSATQAPSSPFGAAPPLHASGGVGFTIGSAAPQQVAPGARQIKKLPTRNRGGRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQY7</accession>
    <name>A0A2G8RQY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfide:quinone oxidoreductase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13670</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SQRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQY7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQY7"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000034">
        <property type="entry name" value="sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0874">Quinone</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="422" mass="46299" checksum="C51351ECC7252280" modified="2018-01-31" version="1">MFLDFFLPRSAHSGSAGLTVANQLYNRFKSAGKALNPGDIAILDAAEYHYFQPAWTLVGAGLKQKEDTRRKLDSLIPSHLAHIPENVKTFEPKTNSLTTASGRKIGYESLVVATGLQTNWSSIPGLEKALADPKSGVSSIYSYNTADKVWRDIDALRSGKAIFTQPAGVIKCAGAPQKIMWMAWDRFRRTGRGDMVSIDFYTGMPAIFSVKKYADALEELRIQRGVGIALKHNLVSVDPEAHKATFTTADGTVDVDYTLLHVSPPMGPLDVMKGQPIVDEGGWASVDKATLRHTNPEYGNVWAIGDCSSLPTSKTAAAVTSQAPVLTENLFSVVDTGKLSSATYDGYTSCPLLTGYGQLMLAEFKYGLEPKESFSSFLGDQAIPRAAYYYLKKDFFPWTYWNFMLKGNWFGASGFIRPTYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR08</accession>
    <name>A0A2G8RR08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR08"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="193" mass="22125" checksum="301C736FD4F49C75" modified="2018-01-31" version="1">MASTARPSAILREAREESDELCGIIESKLVRRITDRVSGYVLRCDVASQTKAELQSELKIIIRQIVDYDWIANKNAPVERWLVELRECTRQCRPDFEMTRYFAAMARDLYARMTERRLAVQMGALSSARDQALRTDRMAEQLADVSHDLTERIARNIDYLCSPEASDAAAFEEWEDMPELEEPGGPIAFEAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR31</accession>
    <name>A0A2G8RR31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSI_13718</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR31"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR31"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="4"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="767"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PIL23967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="792" mass="89987" checksum="FC22901DCC03010D" modified="2018-01-31" version="1">MSLPLRLHPVAQQSAQEQYAYMCDLKRTLDATGHCVLEMPSGTGKTVSLLSLIVSYQQFYPTKRKLIYCSRTVPEIEKALSELKRLMDYRKECSETDEEREKEQNFYGIGVTSRKNLCIHPEVSKEKKGKVVDARCRDLTNSAVCTKGRENPGSVELCDWHENLGKLEPGNLIPPGIWTLADVLQYGRDNKICPYFLVRRMMPFVDVIIYSFHYLLDPKVAEQVSKELSKDAIVVFDEAHNIDNVCIESLSIDLTRPMLDSAARSVVKLGDKIEEIKKTDASKLQDEYAKLVEGLQEASSDEDAFVSNPVLPEDLLKEAIPGNIRKAEHFVAFLKRFVEYLKTRMRVLHVVAETPLSFLQHLKDITYIERRPLRFCAERLQSLVRTLELSRIDEFSSLQKVASFATLVATYEKGFLLILEPFETDNATVPNPIFHLTCLDPAIAIKPVFERFSTVVITSGTISPLDMYPKMLQFTPVVQETYSMTLTRNSFLPLVITRGSDQVHISSRFEVRNDPAVVRNFGSILIEYSKIVPDGIVAFFPSYLYMESIVAAWNDMGILNEVWKHKLIFVETPDANETSIALENYRRACDNGRGAVLLSVARGKVSEGIDFDHNYGRAVVMFGVPYQYTESRILKARLEYLRDAYRIRESEFLGFDAMRNAAQCVGRVLRGKTDWGLMVFADKRFARADKRAKLPRWINQYITETASNLSTDMALTVSKQFMRMISQNPNENQTGISLWTLADIEKAQAKQKELALQQEADRRDAAMEVDEDDEYGDGGFDDEALGAINLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRJ7</accession>
    <name>A0A2G8RRJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRJ7"/>
    <dbReference type="OrthoDB" id="3261349at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="322" mass="35296" checksum="8DB176C94693AD22" modified="2018-01-31" version="1">MSSVVSQSVRDAAEYWASTVRTDSYITVVAFTILYYDFALTVVSEIEFFWTSANWSIISVLFVVNRYFGLLGTVPLGFEYFGTPSEQTYHQAFAIATQAIVAIMLVIRTYALYDRSKRILAVLIVAHVGGAIGCLVAMLTTKSPNATNIPLPFTTSGCDLSLTNAQGLHIAFAWIAMLWFDSTIFTLTLVQTIRMRRYFPGGILEKLLRDGTIYFGIMVASNVSNIVTFLATPSGSNLKGLETTFTNVLSTTLTSRLILNLRDPTLGRPRRASETQPTTTLTSTAAPPTSSYMMSTRYTLTHIEAGGVLTNTEDISAVSTMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRT6</accession>
    <name>A0A2G8RRT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRT6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRT6"/>
    <dbReference type="OrthoDB" id="3236040at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="273" mass="29377" checksum="414EA820C470B5A3" modified="2018-01-31" version="1">MPSLRRTLSSPSVRSSPYRNPSSSAPVHQTRVGGNQPRRSSGSDTSNRRVLADIDWWVVQDGQREFVAPSGEEEGSDEQVAAENEQVRPRPRATVVASEDVVAVPPPVVADPPTSVPAVGGFESPILSSPLWDVSTDDSFGLSTPEVMSPLPHFAALSLGPRIPLRRHASQSSQSSLDSSFESAPGSPFLPTYMDVIRPAAPAYPSIFASSIGARRPAGRVPPLASRSVSYSAVEFQLSTSRFSDSRFDDMVPTPPPFFSSTMGDDEMDDLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRZ2</accession>
    <name>A0A2G8RRZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRZ2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="131" mass="13545" checksum="A9B697DC932294E0" modified="2018-01-31" version="1">MLSTWYRRLTVTTSGNSTVSKCSRRASAEALAKQHRSTHHKSSTEGCSHHVTRIFLSLGQTISPSSPSDVSPSSSSSHPGLSAPSSSSSSGSSLVLAASAAKTSAASSGCNRSSRLSSLGTLSHSRRNRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS54</accession>
    <name>A0A2G8RS54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_14074</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS54"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS54"/>
    <dbReference type="OrthoDB" id="300641at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013681425" description="P/Homo B domain-containing protein" evidence="17">
        <location>
            <begin position="18"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="732"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="18">
        <location>
            <begin position="477"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="634"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="801"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="705"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="802"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="841"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13 14">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL24321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="885" mass="95968" checksum="BF5C8A9271E277A3" modified="2018-01-31" version="1">MRLLPFTLALVIQSALAVTPAKRFYNTHDYYVLEHDPLAGASLAEVAGALGVEVVEQAGELANHWLVRVAKGLEKRDADPVLRSLDDLRLEARSPHSPRSEHGLRRRRIASSVRDIFPQTLRQRVKRAPPPIRPPKTETSEDVALRLGLHDPEFGRQWHLINDEYPEHMMNVTALWEEGIAGKGVITAFVDDGLDYTSEDLAANFYAYGSYDFNDHTDLPTPVLFDDHHGTRCAGQVAAVKNDVCGVGIAYESKVAGLRILSGPISDVDEAVALNYDYQNTSIYSCSWGPPDDGRSMEGPNYLIKKAMVNGIEHGRGGKGSVFVFASGNGGRNGDQCNFDGYTNSIFSVTVAAIDFKGLHPDYSEACAANMIVAYTSGSNNHITTTDRGKNKCSHTHGGTSAAAPNAAGVFALALQVRPDLSWRDIQHLCVRTAWQVSPTDPDWEKTAAGRPYSYKYGYGSLSGLAFVKAAQTWKLVNPQTWVDLPVVQLNNGTMDSSRETNGGTPIPEHGVESKITVTKDLLAHHNFGTLEHVTIKVWITHTRRGDVEVELVSPNGIKSVLAGRRYGDGATTGFPGWTFMTVKHWDEDPVGEWTIRVSDQHSEDQSGVFLGWTMSIWGAEADATKGHKTYVLPSGDNVLPPPPSNATDDDASSSVVPTSTKTLTGPTAYLPGDHGESEGENHKPAFSSGTPARPTKPAEDVTESASASPSISATPDEGWFPDLGKLTSNKVWFFLAVGAVVLFGAGAGIFFWRRSAARKRRANYSSLRGEEDLPMSAIGRATSGGRAPRQTKELYDAFGEVSDDEDADEETALRPRATSHGLDTGLHAGFLDDDPSSAAGDHKETRYRDEPDSPVNPEQKERSRSTSLGSGSGGSSWEHASETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT60</accession>
    <name>A0A2G8RT60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13413</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000066">
        <property type="protein sequence ID" value="PIL24538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT60"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT60"/>
    <dbReference type="OrthoDB" id="2446696at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072:SF52">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="159" mass="18616" checksum="D5B5E79D681F9795" modified="2018-01-31" version="1">MYDPDCKTRIEVDASRYATGAVLSQEGEDGKWHPVAFHSESMSDAECNYEIYDKEMLAIIRALQAWRHYLEGLPSVFEIQSDHKNLEYWKTAQNLTRRQARWALYLSRFEFVILHKPGTSNGRADALLRRPDHQTDDADDNLDRVLLQPDRFRITIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTG7</accession>
    <name>A0A2G8RTG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTG7"/>
    <dbReference type="OrthoDB" id="3193353at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="572" mass="64273" checksum="5DCE0E498EEE0FB2" modified="2018-01-31" version="1">MTPVFQLQDLPGDVLFHIFTFLDIRDIVYLRKTCKALEDLTRDRSVWHDVLSTRFLQKGLPIPGIKDRCVSSLSAAGLERVTIRASRYWSNWISPQPQCYFSLEIRPTARPWTSIPSHRNLAAEFLPWMDGRYLLTLTLYTTSSDRESRRFSFQCWDLAQTQTQGAPTEIAELLVSGLLSYAVNTSPDSPNVLAITLRGGNHTYMATTYTIEFTTPDTEPWFRRTGQFPSTRRILGLEGSRLVSTDESNIVRVANIESGTWMCALKVPLIHADPTLRLPEQQCLGYHIFGDFIVTFCKQWIYLYHIPDSLASLPLHTDDHTLAAPSPLLDPIAEYKWRWRIDSITVNPRRPHPSSRSFSHSDHTPPAIDLLIRFDTWFPWPVNILHHYVLPPNPTFSRSSFSPTARSTFPYLRSPAPADGPLMAHAIPSPLRLFTPSDMVLGAYGTALWLDASTDAATPSQAGDRGQRIAMRFLAPSPAAVLQAGEGLQDDQVSPGMTVDAALTDALGAMALDEQSEVRMREWEHGVSVLHSQETHELWNRVAVNEEEGQVAVGYTDGRVSVYVYAPPEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTY7</accession>
    <name>A0A2G8RTY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_12857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTY7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTY7"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="119"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="214"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL24970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="314" mass="33419" checksum="0B7E37B81EB82A73" modified="2018-01-31" version="1">MAEHMPEHLEEIEYEGLSANAGLGVSMAAGALAGITEHAVMFPVDSIKTRMQVFATSPAAVYTGVGNAFTRISSTEGMRALWRGVSSVIMGAGPAHAVHFGAYEMVKELAGGNVEGAQNQWIATSIAGASATIASDALMNPFDVIKQRMQMHKSSYRSAVDCAKTVYRAEGLGAFYVSYPTTLTMTVPFTAVQFTVYEQLKSLLNPHGAYSPATHIVAGGLAGAVAGAATTPLDVAKTILQTRGTSTDPEIRHCRGLVDAFRIIWARDGAKGFVRGLSPRVLTFMPSNALCWLSYEFFSASLSRADVPGLWVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUG2</accession>
    <name>A0A2G8RUG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13045</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUG2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUG2"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="105"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="471"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="588" mass="64122" checksum="2DB2481A4352A2A7" modified="2018-01-31" version="1">MVDSSWAPHQHRNNRGWASFDSDRPRRSGSASWLAKLLGVSTELPTYLDEKPSGGPDFSHRLRGLKRTLFRRLPSMDWSRQRGHRLSSSHDQSAVVMPSASTVRFILMCCLWYTTSALSSNTGKSIMTTFRYPVTLTFVQFGFVAAYCLLFMSPVVRFSKLRRPTKAIFETTLPMGVFQVGGHIFSSMAISRIHVSTVHTIKALSPLFTVAAYALLFGVGYSSKTYISLLPLTVGVMLACSHDVDRSSAVGILCAFGSAIIFVTQNIYFKKVVPSNGGQSSHKLDKLNLLFYSSSMAFVLMIPVWMYYDLPVLLSIDETHIVHPTHGHATPHSVTYYFIANGTVHFAQNIIAFIILASTSPVTYSIASLIKRVAVICIAIVWFSQTVYPIQAVGITMTFVGLYMYNSAKSDVEKGEHKMRRVEAARDLALPATKADLASDGEATPPRSVTPAPVSGMAAVSVTSAYGRVHAGATPSHHAPPHASYPRAPALPSSYSSAPFHQAPPPSYSRSHPQTNLHIKITPPSANNSVSPVDSYPSPPASLDSPPSSAVHQAPHPQAPWTSRQRRPSVVAGHQRVEAPPRRPVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUR8</accession>
    <name>A0A2G8RUR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUR8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUR8"/>
    <dbReference type="OrthoDB" id="16729at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28360:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="282" mass="31407" checksum="C04B4E9D24FBCE88" modified="2018-01-31" version="1">MSHIGSVFLGDVQRHRHLSTSTPPSSPPPNATVGPGATYSFGGVDLDDTDQDKAPRSQPAPPSISPALSLELRLRWLETLLFGAKHDLQDQSAKGGVKAEKLKDGETLTRRAEDLQRRLDGVAQSNDALKRFMDRYEQYAHMLTPAFALSGTLPVNPPTYENMSSSELDAFLAEMESDIRGAERDLREISTLENKGVTGAGKLGDYEALQPRLEALLQAHDEDLRMAADLEKRIALLMDHYATNVDTLSELFVSWDETIRDAEEEVDKLEKDRDERRKLGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW38</accession>
    <name>A0A2G8RW38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000047">
        <property type="protein sequence ID" value="PIL25548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW38"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW38"/>
    <dbReference type="OrthoDB" id="2800707at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="109" mass="12305" checksum="1275CB1E40FEA1E3" modified="2018-01-31" version="1">MAFPVDVFHAVKKHGADDGYCQEHCNPAGFPELVDDQKAWIFNSSVCEQINVWFGKFLPVVREMSEVHFNFFLDEMIAIHNALKVSTLHSTGCRPRLIPVEELMSPVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW99</accession>
    <name>A0A2G8RW99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW99"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="374" mass="40391" checksum="A60696F258821293" modified="2018-01-31" version="1">MAPILRHPFIPSNLYNTCQFCTRGRGSPYHTREQSASPSPGTPSWTSLLYAFTPSNGTNLCLHCGHPSDGTWFHFISEFPPDDSKWFPDPLSDPDGELSSDADSESDEGSPPAQLLAEFEETTRILDVLREFADQAFKATADPAFTHPLQYALHLMKTGFTSLTSPPPPSLVLSDSSCVACKLKDDMISDLEDRFPTPPRVLADAASQTPHPHHLECGTQATPPLPPAPPARVLTDMGSQTPPPARPPSRLAQTPPRSESPTPFSPSTRKDFEKILARLASLRREVSPPPSPPLTPRAASPALRTPSIAGHFHLTIAIPHGLQSLTLDLVDQVPANIYTGSLKPTSPPPVASAQRGRSRGRPLASPVWGTRLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWD9</accession>
    <name>A0A2G8RWD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWD9"/>
    <dbReference type="OrthoDB" id="10611059at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="857" mass="92194" checksum="36CCDCA1E2EC35E1" modified="2018-01-31" version="1">MSTASIFRPPPTPTQVDMLRMLSSKIHYAFPTRPPVGSPLRTTWDDRFLRDVVPLLNILNCATFKTLPTLAMGCAWAANLRLREKPRKEMLDIDAIQPVIAGHPALNEVLPKGMKHLTYEGDDFGAMDLLPEEALPDRWWAAFASAEVRMDGSSVEGSHSSPSSTRDAQGDSTGASAGDVRQSEGQQSAEAASGDGEMEVEGESEAAADEPPPWFQEQFGVDKPKVPRSAEGGASEASASDKQTITRMASTRSSARGSKGKERAASPAASVSATASAPAAASGRTSRSQAAKLTRSASAAPHTSSDPAEAKTEASKTAPHSVHSAKTRSKSRAKSTDAQVLADDPASSRGRTPATGSSAAPIDVDAMDVDGVSPSPALRGRPIDTSHLRLRRSPIRARGSEFSYKTTSNRRPSPSPDRATQSPTESLTEPPIESPTEPVDATVPPVEGSWRSIPRLDDVLLQLQSATVAEHDSEEDDLGADPSPATLDDLQPISDNGGTALPQTELMKSNLNAVAGIVQCTKEWAETLGAQSKRVLEWSERAMGDERDWSRTEVVDAWFNESQDLGDDVARLSRQLADTNKWVSLLARCLKDLMASPIDGDTLEQVLVEVARLKYAYEDSVRKFAALQEDVRPVRREVHRLRWRTDAAEHTAEVAANEAARAIEPLLTNLYSQLSAEIDAVRIAVSRPMERLATTIALPGGLTPPMVQEVIAAIREAVAEMWRTTTSISKFIEGTCVRLSSGLSAKVRDLEERLLRVEGTGADSQLGGTMAAADVSLPQLARAIESLSLRVDALQREVADDQAFDRRVQESLGRIGLMGDFGELDAFDRRVQQSLARLGIAGEVLQRVAAGRHARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWE0</accession>
    <name>A0A2G8RWE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWE0"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="110"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="206"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL25807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="283" mass="30603" checksum="7A17C34EC830E3CB" modified="2018-01-31" version="1">MVDIVSTKGEPSASTVTASTASATSMTFPQAHALQTVEEPEASIFVAAQRGDVETLRHLIESGKAHATDRDEQNITPLHWAAINAQVAACRFLLEQGAEVDALGGDLVATPLQWAARNGYLYVIQLLIAHNADPNINDAQGYNTLHLVTHSSSIMALLYLLHQPINVDARDSQGHTSLMWAAYQGDALSVELLLKHGASANTKDDTGLTPLHWAVVRGNRVCIRRLVEAGADVHAKDGEGRTARDMAQELKSLGAWKRALDEGGFTEDGVPKRKPLSERAEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWS1</accession>
    <name>A0A2G8RWS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWS1"/>
    <dbReference type="OrthoDB" id="2763996at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="164" mass="17873" checksum="C47DDAEC393B1EC6" modified="2018-01-31" version="1">MAMAMALPPDQTPTPCREREWLYLGIIDTRDAKICRRAKRIERLTLRLDQAREALAARDAAIAGKEQTISENAAALAEMDRTIAEGAEALAAKDAITASLTEDVEHLQLDNADALSMLSKKAHISDLCLQLDTTGAAEMRREVCTLCPYFLETALAISGLTSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX67</accession>
    <name>A0A2G8RX67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX67"/>
    <dbReference type="OrthoDB" id="2757830at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="28668" checksum="CDC9C32849E4E934" modified="2018-01-31" version="1">MPILGLSEATLRGRSSEDLRKNNREDQIAHGSWTTLEYFMAITVDAYMAGLTCRIPSLHLIAWGGPMEDEILAICAMFSDALPSHFRLALRPAHVDYLAALFYERAELFSSLSSLELRLDLADMPFDFKSFLDTIGTALQRLSIASLQVEIKCLTHLSSKRSESYCRSIGTPRATCYTLEAMANEEIEGRMRYFLKKVPTLRRVTIAWGQCVFSVPNHVITMDLDSVPHISERVGRPGDKYWQDGYHNWGIAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY74</accession>
    <name>A0A2G8RY74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_12195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY74"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY74"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF10">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="10"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL26437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="578" mass="61070" checksum="7F77CBFAC9A4B5B4" modified="2018-01-31" version="1">MPSILYNSLFVLSVCGVTILNIFVNGALIIALPTLGKALDFSESELQWPLNVYALSYGSLLLLFGRLADVVGSKRMFLFGTGFFTIWSIATGVAPNKVALIVFVALTGVGAAANTPTGIGIFSNHFEPGPSRNRAIAALGAGQAIGYIVGLIGGGFLCQSGQLWRVIFYIQGGLAAVFFALGVYTIPPDGERAKYDKGIDWVGAVLSVAGVGLLTFVLSESTVVKQGWKTPWIIALLIVSLVILGAFVAWETYRERRERSVIMPISLWTKPGTKMGPMVTLVFLAWASYNALSYFITLFYQQIRGDDPVHTSLETLPFAIMAFIVNVVAGWLLGTVRGDVLIGVGLLGTLAAPLIFVFVDPHASYWKGAFLIMLTISWTDVAYTVGNLQISISFDSRSQGLAGGIFNVATRLGTSLALALSSSVASAVSQSYHAKHPELAVDSKGVLMAGFRAGGWVSVALAAAALLVCVFGIRGIGVIGVKANPDMVLVEGEGKADKVGDVESGVVIDGQTAEGMLRNSEKLRTSVGGAQVVTLPSIRISTDVNAPRRTSVLISPGGRHSVQMIPPSMEGSATRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ33</accession>
    <name>A0A2G8RZ33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ33"/>
    <dbReference type="OrthoDB" id="2758786at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="55710" checksum="A1D68CEF3ADDB495" modified="2018-01-31" version="1">MFEKQVADAFGLVLAKRKSIEKLTIAFDGQQAAAVEAFVKAIGAEVTLLSLLPNNSLDKVRWDFAQDSFPRLDRLVLSCVIPVPVPGASLLSLTHLYLHDVLESFSDVDRSEKPWTFAHRFLAACPNLETLRTVDSFEYPLEYLDLHNDYDDLPVVTLPRLHHLSVEGQALDTSTALGTLRLPTLSTFDITAFPGRDPYDCDFYVIPQNVSESLPPIRRSRSLSFIAGGRANDLSLRGGPGPGPNSTFSNDSESDCQWSITLPDLAATHARSDLLGLPCCIRYTCARFLARLPHLVVPSILVRLELHVADGLPIPALGDLARFFEDMTRLRTLVIGSDKLIARVLEAFEAEAESRVCPQLEELELCLGEGPTRAEVGPLVEFVARTVGAWVRGGGMKLQTLTLLVRMGSDADGEDLGPRSGSDAAPDVVVDVVGQRGGFQVDDGAGSAHDSELAYLKLWCDLSATLKSEGSESVGEVRLKMVDCAACNVEYKPVDSVEFDDGVLSEDVTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZC3</accession>
    <name>A0A2G8RZC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZC3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZC3"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="56"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="154" mass="16993" checksum="9FE3B9D77EC6B666" modified="2018-01-31" version="1">MSDFAPPPPQNIAPQNIAPAVQGDVPGVIPQPAEDAPEPPPITEQEVGEYREQDRFLPIANVSRIMKGSVPLTAKISKEAKECVQECVSEFISFITSEAAEKCQMEKRKTIGGEDILYAMVTLGFENYAETLKIHLAKLRQVRLSRSCLLFFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S009</accession>
    <name>A0A2G8S009_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_10213</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S009"/>
    <dbReference type="STRING" id="1077348.A0A2G8S009"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL27074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="94" mass="10149" checksum="130A289157FC0E6C" modified="2018-01-31" version="1">MSSFAKALSPAVREIRILCCQTGAASAGTRQFITSHYPTLKQHNPDLPVLIRQAKGTPARVFARFERGQEKHVEVEGLSAADVASRISQLVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0U5</accession>
    <name>A0A2G8S0U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0U5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0U5"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="374" mass="39824" checksum="220041E0C5B8AF24" modified="2018-01-31" version="1">MLKRQDSKDSGSPTFRRPSWTGALGARLGMRRESALDEQSIASEETYGTMVDGASLESLKQAFGVMVGGRKRDDPDSPSSFDRRSVSRGREAFSSGRGGIGNIRRPSVEAASPPRGSGGEPLSPVRGREARVDPERAQSTGRGGMGNIRSGSRARNISLIPENHPQTASLVSDHAASVAEYERAVLERSEEAANARARSSGRGGIGNIKSGDNSHSRSRSRAPMTSIGRGGAGNIQTNINTDTELLVQLDDEERLKYAHDEGVHSTGRGGRANLTSKHTPPLESVSAHPYEFETTGRGGVGNMIRSRSSSREPDQSRSRSASRTPSKDRASSLARILNRVGLHSPREGEGSESPHGMSSVTELTEPSAAARASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0V4</accession>
    <name>A0A2G8S0V4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10551</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0V4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0V4"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="287" mass="30209" checksum="1FB4B6E35DEFEB5B" modified="2018-01-31" version="1">MAAALTHAHPLLQAFRTSKPAFGAWLTLPGALNARVAASASPHLSWVLIDCEHGMTGLHPGASESIGAIAGLGRDAPSTIVRIPATGACSDGSATWQIKYVLDQGARGVLVPMVSNRTEAASIVSAARFPPTGARGFGNPFTHLAWGPGVSATDYLHRANESVVVLVQIETRDGYANLEEILSVDGLDGVFIGPYDLSLSHGFPTPSPDPHPEVEKMIQNILAVAHAKEKKCAIYCNSGERAAKRAKEGFDMINVTSDRGAMAHGLSNHLADAVTDPEMGAEREIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0X2</accession>
    <name>A0A2G8S0X2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0X2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0X2"/>
    <dbReference type="OrthoDB" id="2563900at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="406" mass="42360" checksum="A7C461AD7E26FF48" modified="2018-01-31" version="1">MTTPQLSPGPQSLTVLTTSPAPTPRPADAHPPTMNGTTISPAELRHITSATNLVPSSRERKLSSHNSQHLRTHRLGSRSPASIPSSPTSVHSSSSAIFERDIEPIASTLPLTVDPHHIPRAKFTEEIERSVPSVLDSAAAVLTSTNPDDDDLDAISIVTPAPMDPGYQSGFTSPMSRLSSRSPSPTGNRRSLLFSNSLPGSPPRPIHSTSPVRPTVQISSSPPGPMSTLPSTVTPTPTSTHFSAVSSAASDADADSNASSPTTAVHTENPLRSLPSQPQQLTSITVPAPFPSHPPSPKNVTKRLSFISYMDLLSSTPASAIPLSSLTSSAVVSEPPPHIPSVMGLPQAHYAASSSGGSIHGAPTFVLERDGAVGVDDVGGEWEREGLGKGLEERLEALNVAMPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S127</accession>
    <name>A0A2G8S127_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S127"/>
    <dbReference type="STRING" id="1077348.A0A2G8S127"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="448" mass="48101" checksum="D5E66E5CA3AEF5AF" modified="2018-01-31" version="1">MSIFYDLVGRNDLEDAYAIESQGYPDDEAGSLEAFQYRQSQAPELFLGAYVPTDSGRKLVGYVCSTLSPDATLTHESMSKHVPGSSSVCIHSVCVAQEYRRQKLGLGLVKEYISRLSTNNDSSPAPYTRILLIAHEELRGFYEKAGFEWVAQSAVVHGARPWFEMRKALKPDLPQTSSSNNPTSQTPSISGSTKGDSIAAVPGCPTATQPPTDTDEKNVVSGTAPSEARSQVPSAQMQMPTQSIPPNIWEALQRESSRTRPVARLLASFPNAVQDVTSDDNAGDARQGSSNANTNKYDLLCPRAGCGSVILKAGVASSVEGASVQLEPPHGHAVPEALGALPVPPAAAQWWLVRGNAMAFENIGFSRPVQGAADGWRFSTDNWRRRFRNSSSNHCAFISGTATTIVPSGSGKSMKLLACAECDLGPLGWCQEGGSEFWLAVNRVGYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S198</accession>
    <name>A0A2G8S198_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL24-related N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_10665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S198"/>
    <dbReference type="STRING" id="1077348.A0A2G8S198"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="31565" checksum="6DF1857746925401" modified="2018-01-31" version="1">MSSDVRLSGAGTDQICQIFESIRYFAVFSAPKCVEMFEWLHNGRTRIRERSSSDCDVSSRGTFPNENLNYSAEWYGSWCPTWLCLASFGLWHTQSGSKTIHNANDTLPAASNSRRSLTLLLGSHLSAQMKLEIDSFSGFRIYPSRGRLFVRGDNKIFRFANSKNESLFLQRKNPRKIAWTQVYRRMHKKGITEEVAKKRSRRTVKHQRGIVGADLSAIAARRNQTAAVRAQQRTAAIQKAKAEKKAKEEKKEKTKPAHKPVSTAPRVSKQQMKGGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1A8</accession>
    <name>A0A2G8S1A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1A8"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="671" mass="73015" checksum="B08BB9F12B9B0CC5" modified="2018-01-31" version="1">MLLISSQLATTICHIRQILTQHVQLSVPTRRLKDTFVDGGIATPGVEDVKEPLVTREEDEAVFRRSGSPSAHAVPDVVQDIDGDDGTVVVADPAPAAQPSRGGSGGAKTSFTFPPSEDLTLEEMRAWSKEEKSAFLLQRCAIDPDVVVECEVPGPDGRPCGARFSRWEIRMARRHFIRTHVPKPMDDEEEAPKKHEVPSTPFFTRTFFNSRLQTHTATSIITSVPPRHGSGSATLHTRSNLFIVELNMSNAIELAQHYKAAFIREEGSLAAWASELQSALIVLRHVLVEHDVSLDRHGVVHIVDPNEIDSESTGDFGAACDAFDSFINDYYDPANKYQDGTTFSQPTHQNVDHYLPNCKPAFTVDTPQFNELCTIEDVLRRKDPDSRVGGRGLCHPHAYLPLSEPFPSPRCSTMRHTNMTPTTTPLQTTKSCPSWGVKTWTRPLCGTSTSVPSTMSTTLSPTTGSRGAEQPASPLRALFYDDEESVPPAGIRRESTLEVLDRASLPTAGPSRTASQTRTWWALQRMDSSFGSEFGGSDAVVYGCSERDEGSILSEDEDEEGGPEAVEEEHAEDCVFALHHDDDGSDSTEDGLLGAEAFEEEGPEDDAESQGDNSSDEGVAEDEATEDAPQDVPPPSSPVVGPSSGLRCSTRVRNRPAPFAPPLSKEGQGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S323</accession>
    <name>A0A2G8S323_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S323"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="75" mass="8765" checksum="22D4989ED576C29D" modified="2018-01-31" version="1">MTRARSQNRSFQSYRIDWYRGSEQNVAVDVPFKFITYSRVFRVKHVHVNHSFAQSSLALLLSESRGPPVPGPWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S378</accession>
    <name>A0A2G8S378_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S378"/>
    <dbReference type="STRING" id="1077348.A0A2G8S378"/>
    <dbReference type="OrthoDB" id="5835136at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="493" mass="55076" checksum="0BB3337EDEE77FA9" modified="2018-01-31" version="1">MTTLSNIAIETRGKYSLFGVIMLCDISQAYTNSRFDNTVNSIRQNRSRSAPTTSLTSVSPTATNKMTTSTSGMMPVKMLRTSTSTTSTLVQPTTISTTVAPMTTSTLGLPGYSPASTPPLNPYAGFLGPRARHSVVLHKLRNGLKSRELLGQLLHHFLDTKKVRRGLAKLPTKIDGALDKVMAVNDYAPHTIEAAQAQEPSVLVLVLLPFGGPPPSRTAALVAFQQSMDMHASKLRRLRLEAEVSATLLDALDAHLDTLHEICTREHLDLGTLRDVLLAEFWMILGWNHDRVCGFNSSLGLLREVGEYRKHASAHNRAQGESRIGHRFYVPLRIRTSYKARLEAVESWHVPEVEDEPEEPRWVLGRRKKRHPPNEPHKFKSAFEREKVAKKSRALFDVYYRLLGSNQFFLGSALLTTLDVVFAAHTHLLLKTAFPDPLVSCVLTESYPRFVTHYDAVFCASFSNPTRLPPVIEKTWTSSLHCVWQYRKAVLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S412</accession>
    <name>A0A2G8S412_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S412"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="139" mass="15023" checksum="2DF05EB9DA53D218" modified="2018-01-31" version="1">MTNSSSELPSQEPGIRDSDGTLYGYIPPYKRPVSYASFASDLKKHSPSEGVIPGVAGDRRLTVDAEPNTRSPSEHSLGDSRSVTGQEPVESVLPPSEFLHAVAPAGRRRDAGRLTDLDEDTRDSFYGAVNTLGLYILFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S425</accession>
    <name>A0A2G8S425_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S425"/>
    <dbReference type="OrthoDB" id="2766707at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="22503" checksum="BCD42AA466C26CD2" modified="2018-01-31" version="1">MTTRPSITSPPPPSPAAHQLNTGTIVAITLSALAVVLASTLALCFLSCRRGRRLRSRTSKRASVGSSNSQQHLEPHTYRGRWSRRLSSVWTGFGSVSVIPGIDPPGDVWRHSDQLSFRLADSEKTEPDASPRPSLAPTEARSLVRDVSVHSLHEGIARVQATSPSSELLALAGIDYIAAGPVRNKGSEWRRSIASRVTASSGGFQSVEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S461</accession>
    <name>A0A2G8S461_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S461"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="152" mass="16974" checksum="22AF769DC64485AA" modified="2018-01-31" version="1">MSTSQTSNNLQDDAPQWLLGIPWEALVVQDALYKAANAPATIPKAEELKLRALAEADRKDHYPSYGFDWALYTIGEVIEEEELDTEGNVDDGLDPLTNEDVLVFVLQRKSGAVSESDLDKPGSPDIMAPLATDAQVEELKRRGWVVRWYKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5V1</accession>
    <name>A0A2G8S5V1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5V1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5V1"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="41275" checksum="9EE4DC6760C5B30D" modified="2018-01-31" version="1">MVNASTLLGVVLLARHGDRLEFFQDPLTYNPAQTFLTPLGSVQELQLGSFLRSQYLDPRSPTFLNGISYDVANITQLNVRADGGGEGAVILESVYGLLGGLFPPTTDNNITLANGTTIVSPFGGYQYIPVESVEQNLDISLNSFTSCPNFDNHISQFYSSGPFLAEAAIAAPFLQNLQPFLGNRSTNFTNMFNIFDYVNVQSIHNATFFNQLQAALPTANAQAYGFANFHEGGVFSDGSPSGIGNIAIRTIVPSIISSLQGFASGGPVKLMLNEISYKPFISFFNVTQAAASQPLLNGIVDYASAVAIELHTSRNATSEPTVYVRFKNGTTDPTFHDVQIFGQRSLPLSQFVSKLAPIAVNTTQQWCTACNQTSLRGCSVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S611</accession>
    <name>A0A2G8S611_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S611"/>
    <dbReference type="STRING" id="1077348.A0A2G8S611"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="548"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="272"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="691" mass="76464" checksum="C34236FA596F90E1" modified="2018-01-31" version="1">MPKLELHNLKDTTNPQSKQIQFLENKVNRLRWVNDDLNKQVFNAVQRGHRLAAKLGYEDLNAAEAALATQAGGEASQLEQLSQRSSEELASHVQALQSELVSHVHLSKTTLSALEDALAELSVMREENEKLREELAKARVERKSEDAARKGRERQPDPGEVPSSPSKSVELAFVQAEFAALQDKYAALRKAKQESDDKHAKDYRQWKEFKQWFCSEELKKAERHSKRRKLNPPGDEEEQDDITLKVVDNPKGKAYDRVRRVMASGSVVLSKLPPLEPISSPAKPSVLASRNLNSSSSSPPFEVATPSKPGDIPFLPLQLAGRNPSVVIPSAEMPGSSDTESDSQPVGFLYPSQLNVTEVPPTVPLKRPRRPGQDSGSSDTEAESQSAVTFLFPSQIVPLTPAQVSGMTFKPSQDIRRAQQPLTPVSVVRPQAGKLRRKSSPPAGMLPPPSSPSTRDSFHRSLRAASESKGRIPETPTSRPVKKGKERATENDENAPSSTNAASSAKTPGDYSIYKGRGRYGPQAQAAKQTINAMFEIDPGRNGGVDFQFEEVVRDKEKRKGMHGGDCECCRDYYNAIGTLPARPKAPMWRSPESSPSKKPVRISFEDGGDVENETTAIKHHKNAISRHRQQWERAKTPPGYWNIGFPSTQEVAAMNAEAARMHERKRAVVAEEAEALFEFSFNVKRARKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S666</accession>
    <name>A0A2G8S666_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S666"/>
    <dbReference type="STRING" id="1077348.A0A2G8S666"/>
    <dbReference type="OrthoDB" id="2766567at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="37933" checksum="19602D79995D29E8" modified="2018-01-31" version="1">MGALTTPPQVIILRLPPTPPLTTLVQLRLNTPLRSMSSLNPSAPATFVACLVSMGFFGVIVTQFILYIRRYPKDRMFLKLLVYGVTLLQAAQQVLFTVNAWGVVINPGVSGQVLQRVTASNILIDAVIVAISQAFYASRIWTCDVYYAGRGMRKIHASISSSKLLLIIGTEVHFGTGQHGAVFLVYKILSVVSSDDDTMIKGILISVNAVTWSTGLLLSAIFVYSLLKSRTGSSFRVGWILFVVNAGTFTVVWGIAAFVLLLRGPYTVVPGLLYVTGSNSYTMSLICSLLSRFKPEDWENEGPIEVELPDINPGTFVLSTVEAQATSFQTHTAEEQSVKASSEDGARGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6P7</accession>
    <name>A0A2G8S6P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6P7"/>
    <dbReference type="OrthoDB" id="2764849at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="162" mass="18435" checksum="86EEB0860F60F94F" modified="2018-01-31" version="1">MHEQGTPNPDSKRRKLASPTLPTPTQLAPQPERQMGYVKDLSQAINRLTNHTLYLKEKVKCIDGIDGDVDALLQSVNNLDDNDEAINAKVDLIGDEVAYATKEIRNTHNEISKLKDLVENMDVQWEQERELRRMREADEQQCFKAMMANVDALVAHFIGHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S838</accession>
    <name>A0A2G8S838_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S838"/>
    <dbReference type="STRING" id="1077348.A0A2G8S838"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15522">
        <property type="entry name" value="PHD_TAF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="617"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="702"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="732"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="913"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="941" mass="102390" checksum="7558723666C4F1F0" modified="2018-01-31" version="1">MTRYDSFNVLMRSEPFGIHNNAADDEDHKQALDERPGNSSALGHAALLPAFGPKKRSHLPTPQSPIDVASYTSGHDDTYASPVRHPYERKPLPKSPAILIEPDVARDRDGGRNVAIEREDATTVSSASFMTPESSPVLPRKLIEPVTPVAGPSMPQNTHYHDHAVSPLAPSPVITTPVSSHSRAITPASRLSSPFQNRRSAGGRHAVKSPSSSPMPPLAANSPIPDVFSVPPPPSSPPPLATPVPQRAMGGEIHRIHLQLAADRAERLAETEARRPAYLVREKRPRSEADIPTLDELDAANATLGVADSPVKGRRLQLFQATSEETFEQSLLAGGYPGYGQSPAYKSGEPQTPTKGHSSLSNRALHWLQHATPGQPGPSTTPLVAIAEPLPTEEPEWLPSEQEVRKRRRLDAFREERREPGTKLYPAVVEGRGRLLLNVPPEGTSIPPDAPVKRKVNKRKRRRGGRRGAPTQDLQEDEPVQPNWPDAAFPWCLRVEERTHAETRKKEERLKWIERFLERESDSDSGEVEDDQELRPPLRSHENDQVAHSRGRGKMVPLRSNPDVTTRTHEENVLVPSDPADARAALLSKRSVRTLATRRKEQRSGAGGGAGEGELENVECIGCDRGDDGTELVLCDLCNVWYHLACIGIRHISELGREEDLWYCDRCLEREPAPPLEPTLVPTDDRSPVRRASRDSLFLQHPHPLLESPTPWGVVERAPPSTPVRGSGGAESMNTGMTRTFSTRSSRGAPSTPESSAKTVRVYDLTPNPFETFDPETPFDPTTTPSRGVKFSGGPPPTLGLSTPKGGVNLWAGRGGATPTPMMSMSKFAGGGGLGLGAGGESAGPRRLNWNDGVHAYSTPVAAGTNARSIYSASYLDDTPITRAPRTTALGGGVAGRRLWNSPGSGRRPATPDGHERERDRQMKRETDGDGDRDVAMETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S925</accession>
    <name>A0A2G8S925_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_07451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S925"/>
    <dbReference type="STRING" id="1077348.A0A2G8S925"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="234" mass="26199" checksum="865F67DA3359BDF8" modified="2018-01-31" version="1">MDGLKGMSVARAELVLVVYAVRRYTNLFCGIPPGDVDILMDDYLAIVSACLAVIVAVYVVRWYNDPLRAIPTVGGSSLPVLSYLGAWRMRGDCRDVLEEAYRKYAGSAFKIAYLDRWMVVVSGRNMVEEIRKRADELSGAHAIQEEMLVRKRSTILRGVIDEVAVAVGDRTVADENEWSSVEVMPAMRKIVARASNRVIVGLPLCRDEDYLALVFNFAAGFMKSTFILRFFPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S998</accession>
    <name>A0A2G8S998_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S998"/>
    <dbReference type="STRING" id="1077348.A0A2G8S998"/>
    <dbReference type="OrthoDB" id="2752736at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="821" mass="92463" checksum="9ECED45458A97F6E" modified="2018-01-31" version="1">MKRSRLPNLGFPIGRSSPSQRAAYTSFQKYAGTGVKLALQTPTLWNTVVTVLRSQEDDRDYCFGRSVYSPKDSSLDLNVHFNTPGPYAPLQQSVEKMIKFMLANSPKIRQLHAWDASSIFDFPSFLQSFDAHALEHCTIVQKIGCGGMGDPSPKPGRLLFFSDGGTRLRSLCLINLCDIPDNEFPSLTLLEIGFTGGCNIYWEVEDLVEFLAGSPKLEEIYVHDVSYWDQPTHSRRATVSLPPISFPYLQYLAFTCLHRNPIREFDVQIDDPSNPIDYLLSRIFSGQPTPASKNVYSPKDSSLDLNVHFNTPGPYAPLQQSVEKMIKFMLANSPKIRQLHAWDASSIFDFPSFLQSFDAHALEHCTIVQKIGRGGLHDPSSKPGRLLFFSNGGARLRSLCLMDLYDIPDNEFPSLTLLEIGSVKRCHVYWEAEDLVEFLAGSPKLEEVYVHDISYWDQPTHSRHKDAVSLPPVSLPHLQYLAFTCWHRDPNRELDVQIDDPTNPIDYLLSRISIPPTCHMYLDAPAVDEAQAVLKSVTDTLASVCRHVPGKHAVSYMFLRLSEPFHRDNPIQLVFQQGSLRLRIPRFLDLRDQSFPYPEFFHTFRDLFATTAELRVHYTHDAILTAFGGSGSGSMPWPAALFPNVAAVSLIRDSGMWWLPEMRPTLRAGIAHLLCPQPEPPASSMSPGLSGLGSEEQSGEHWPYYPALDTLWTSLESRTEIGELETALAARAAQGMPIRRLIVTLRYCPPGTDWDSDDVRRLRDLQVAGPGAEDSDVVVTVMDAEVSSELLEVDWLVRLPERYDLPSSIRRDWPTLWDGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9I9</accession>
    <name>A0A2G8S9I9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9I9"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="353" mass="37695" checksum="A9EFED8F286A9E1F" modified="2018-01-31" version="1">MLEYAERRSALGCGSRSSRKRRRLLNGAFAEGESTVQLVVDQEDEELCDTRVMVFGTDSSWPEIGFKYHPDALKAILFPQSPYEGRPSKRRKLAAIADNASDTPPIEENSDDELVRQQRAVVVETLWESFLISQRGQIPSSELEGDKENASDAAASGGGRRYVIALLTNAGGTMGKLPKSTQRRRQPEQAKDVETADTAPGPIKAVPAADDPPQVNGIGTRGDVNGVAQSGGESPQKNGAPAVPGSGAGQVPGADADVDAKMSTSQDSQTHIDGAQPPESESIARTPSSSEESVDADEGSGPIQILHRDLGEENFEFALDGISVVSGEVVNGMRKGWKLEARQWKWVQVGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAU5</accession>
    <name>A0A2G8SAU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <ecNumber evidence="6">5.4.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cofactor-independent phosphoglycerate mutase homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_07020</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAU5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAU5"/>
    <dbReference type="OrthoDB" id="1886626at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1450.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000001">
        <property type="entry name" value="2,3-bisphosphoglycerate-independent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="entry name" value="BPG-independent phosphoglycerate mutase, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637:SF0">
        <property type="entry name" value="2,3-BISPHOSPHOGLYCERATE-INDEPENDENT PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="2,3-Bisphosphoglycerate-independent phosphoglycerate mutase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 15" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="16">
        <location>
            <begin position="7"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="BPG-independent PGAM N-terminal" evidence="17">
        <location>
            <begin position="86"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="261"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL30852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="523" mass="57774" checksum="ABA9AA3308CDFA4B" modified="2018-01-31" version="1">MVQVKNKVCLIVHDGWGIAPEKGMKGDAIEAGNTTNMDNISKDHSHRTLHAHGLAVGLSDGLMGNSEVGHLNIGAGRIVWQDIVRIDVSIKKRQFHKNDTILESFNRAKDGNGRLHLLGLISDGGVHSHITHLYALLETAKEVGLKDVYIHFFGDGRDTAPRSSAGYMKDLLAFIEKEKIGEVATVVGRYYAMDRDKRWERIKIAVDGLVKGEGEKAEDPVKAIEERYKKDETDEFLKPIIVDGDAGRIKDGDTLFFFNYRSDRMREIVTVFGLLDKPMEVDIPKDLHITTMSRYSADFPFNVAFPPQAMTNVLAEWLSKQGVKQAHIAETEKYAHVTFFFNGGVEKQFADEERHMIPSPKVATYDKQPKMSVHDVAEKVAEVVKAGTHEFVMCNFAPPDMVGHTGVFDAAVEAITNTDEAVGIVYKACEEAGYILLITADHGNAEQMINPETGAPHTAHTTNAVPFIMTGDPEKIAFSVDKKDSEEEEGALSDVAPTVLDIMGLPQPEEMTGRSLLAKSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB94</accession>
    <name>A0A2G8SB94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB94"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB94"/>
    <dbReference type="OrthoDB" id="2687259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="50895" checksum="5BF01E19BB5EF783" modified="2018-01-31" version="1">MFSLTWITRSVAITVHPTSTTPDYGPFKNASQFRLMDYFYGRSDSKSLNTLDDLIAVIRSPGFSPEDLKGFSAKKAEHALDIWVSSSGVFSQEDGWHEGSVNIALPKTGAKYKSEEDVPKFNVPGIIYCRLLPLIKGVVEDTASHFSCFYHWLPHKAEHAMLQADEEIRKKAHNLGDAPGVEYVVLPMLFWSDVTQLSSFSSAVLWPIYLYFGNLSKYVRGRPTEFVAHHLAYISSLPDTLKDVYTAKYGHTSSVDILKFCKHELFQQIWVLLFDSDFMNAYEHGYAINGTCVENWLVKDSLMPIQSTFSTHFFQHGINFYNTLAPDLMHEFELSVWKGVFTHLMHMLTAKGADVVEEFNSQMRHMPTFGYNQIHRFWHDVASHKHLAVRDYEAFLITMMPTFEGLLDLPDDSTIADLLFELVNWLALAKLHLHTAVTLQPNICTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBQ4</accession>
    <name>A0A2G8SBQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBQ4"/>
    <dbReference type="OrthoDB" id="2641762at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="371" mass="41172" checksum="298EC16116CE886B" modified="2018-01-31" version="1">MSKPYYGPLEDQWNIQLQKSLIASDFVTGVAYGIPLVLWLSCATYLWKNRQKGKNTIFLLSYIALLLVAQTIYSITQVWFTQDIYIENQRYPGGPFKYFFVHQDDTADVIAYVTLCIVILMCDILVLWRCWVVWTALDHRLGYLVVAFPACMILASLVMGTFWIIKSVEPGNTLYSPLPQQLGIAYFSLSLGVNVILTTLIVARLLAFRRANIAFLPPEHAQQYLSTAAVVIESASLYSVFAIVFIVTYGLSAPSNVILLGCAQASQVRLRLLPLPSSLLPPPSSCTVTAGRGQGADATDLAQQVATYLIVYRVAEGKAWSKDTLNEQTVSSANFCGGANAHVHSTTPRFINIEVEMESTVDTERLPHNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC78</accession>
    <name>A0A2G8SC78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BRCA2 OB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC78"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC78"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04493">
        <property type="entry name" value="BRCA2DBD_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="3">
        <location>
            <begin position="673"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="BRCA2 OB1" evidence="2">
        <location>
            <begin position="733"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1117" mass="120822" checksum="DD79909134FC6C8B" modified="2018-01-31" version="1">MPESPESGSAHKRQRLSSPTYDEFFPITQQDMHAFEEIDKQLSQRAPSGPSQMQYLPKGGPMAMDTDNVDTDAYGEDGHDTRARDWSSSPPHNRTTTQERAAEDAFFTGAGGGRGFMSAAALPSRTSVDIASTPASGFTSAAAIPPVSKPAKLRASGSFTSSLPDTSGTRSVNPTALDSTTSPSTAFRGFGPASALPARPEEPYDDDDRPSTPPPPPQDYDSWFDSDASALPPDAFAFKTARTIVDSSKTGGDSASHAPQFVGFTSASGLAQSLSVPESGMESGPGESAFDAEAPVASVPFTGGFSSAASMGFSSVAKLNGGKSSWSAPSAEALARAAQKMKQWEHDFAREEASESAAAAKQDIENAHAGPSSYSSAPRPAAAPSFQTPLRPALRPMENSPAQLPDTPLAAKNPTHYTNIGGGVQMKNKPFKSPLVKKQGFAPAAPAVRPGSSLNPANAASASSSKLPAVFTFGSASTVTTAVPATPARAAPVAGPSTAPLSPGKGRSLGMTPRRLPGGGVKSAGKAKFLTPFKPGMEPGEAGRSQLEARMKAEAATQTPVRVGWRGAGTPGPSASASASAKGKAVARKEYKFFDLNPRPDRKSLASSGLRPQSYTQDELEDMGIDVEELRQINPTTAIYYSFHSADPAQDPPEPLQLGPEAAYAQLRELGCTLATQQWVTNHYGFILWKLAGMVCLEPERERNPETKRWCWPEVMRQLRYRYERELNGGSRPALRMISTEDAPAACPMVLCVSSIVVWAPAVVDGAGRPVDPHPELEVTDGWYRLRARVDRPLARAVRRGLISVGTKLAVSGTKLGGDRKEPCEILEAYDNTYLDLLGNSTHLAPWHAKLGFVKDPFIATLDSLTPDGGRVPAMDLIIMKTYPIAYLEFVKNEDGTTTKLGPRNEKEELKAQDQWMTRRDMEVLKIRANLERQIQALEKASERLLGVAGPRFEDKVKRDDPIPSYVEDLYAEMTDESTKPANFFDQLSYMDGGYLYLYTLDQIALAQERFNDDIERELQHICPPRNVRDFRVVVAKDARWQSKEPMRSAQITLWDPMRMVFSEAGSPGDIREGQRFLVTNLEVNQPNAWMDPGPEAMVYLVSKRAARWTNIRSRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCK2</accession>
    <name>A0A2G8SCK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCK2"/>
    <dbReference type="OrthoDB" id="5420143at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013802477" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="216" mass="21363" checksum="1C07045B22BEC268" modified="2018-01-31" version="1">MFVVKSSCLAALALAPWAQALLLQIPVAWQSSSPANISWTNVATDPPFTLQLVNTDEFHDTFSIANNVNPSADFDSFTLPVVPQGTYTLRAINVTNAGQVYDETPSFTIQGPPDTSSQSSAASTASAGASGTLTVPASKTTASGTAAGSSTGFGVTVSNSGSAASNTGAAAATSGRGSSAAATPSNFNNGATSLPHLAPWAIAALGVVAGAAAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD69</accession>
    <name>A0A2G8SD69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tethering factor for nuclear proteasome STS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the cut8/STS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD69"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD69"/>
    <dbReference type="OrthoDB" id="10061064at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031144">
        <property type="term" value="P:proteasome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1590">
        <property type="entry name" value="Tethering factor for nuclear proteasome Cut8/Sts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013868">
        <property type="entry name" value="Cut8/Sts1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038422">
        <property type="entry name" value="Cut8/Sts1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28032:SF1">
        <property type="entry name" value="FI02826P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08559">
        <property type="entry name" value="Cut8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="380" mass="41663" checksum="AC0B50CAA42D02B7" modified="2018-01-31" version="1">MVQSWPSAAPHVQPSPWTASPQPSQTPLRTKRRHEPEDEDRDERMDRSPTPERPRRAVPKRARIIPAAISSVGKEQQHTAKENKPPSQSEENDVDVGFLLATLPPQSLLPLLTSLISAQPSLKPTILSLIPRPTLDAALQGLANSAQKLKDAYPYSTSLFLQSPQSSFSNPGGFGSSRSSTASFSAGFGFGARAVGGTGLGSASSSAPNGGMREEYIVSRLRPHIQEFVSACLSYLPYFSIAVPSEPALSSRSQTAQSHASTLRQQHKDKLHPTETYLFLAALTSHILAQPPLTQESLAPMLASRLAVEWRSWVDRVDETVNREGGMFGRETVQTWERSLDEFAQAKGNGMAVMKDIRDRWVSKVGWLVGRQPVHPMEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE46</accession>
    <name>A0A2G8SE46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE46"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE46"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="270" mass="30399" checksum="44BDC678DE71D64A" modified="2018-01-31" version="1">MRQKRAKAYRKLMSLYSMSFGFRQPYQVLVDSHMCKEATVHKIELVKQLGSVLQGTVKPLITQCSIQELYDQEKDHKFAVELAKTFERRRCNHRQPIPGDECLTSVVGDTNKHRYVIATQSPGLRQHLRAIPAVPIIHVNRSVTILEPVSDATLRAKALEEDKALHPTKPEAAKLTPTTSAATELPRKKKVPKGPNPLSMKKKKPKPEENVSAAKSEFPDPTAQVGEKRRWQDDDQEEGAMSTKEGSTHKRKRRRKHGGQSSSTGQDPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFH6</accession>
    <name>A0A2G8SFH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_05225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFH6"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="695"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL32522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="764" mass="86122" checksum="EC41EC3AFAEC8BA9" modified="2018-01-31" version="1">MATLRDDKHSPASSYDEKLDAEKQVAPPAAIAEFDDPNFDKDALELEDDSPYPEVRSAVANTDDPDMPVNTFRAWFIGLIWSIILPGMNQFFFFRYPSVTVSAIVAQLLSYPVGRLWARVIPNVKIFGVSINPGPFTVKEHVLITIMANVGYQSAYATDIIAVQRVYYKQIYSFGYQWMVTMSTQLIGFSIGGIARRFLVAPPSMIWPANLVTCALFNTLHSQQYSGVGTRGGISRERFFFFVFLGSFCWYFVPGYIFTALSFFNWVCWIAPNNVVVNQLFGYYSGLGMSLLTFDWSQIAYIGSPLATPWWASANVAVGFVFFFWFLTPVLYYTNTWYSKYLPISSRGSFDNTGASYDVSKILSADSTLDLEKYRAYSPLFLSTTFAISYGLSFAGITATITHTFLYFRKQIWIQARRSLSEQPDIHARLMSRYPQVPEWWYAVIFVTMFIFGAVSIEVWHTQMPIWALVLGLAIAFIYTVPIGMIQAITNQQVGLNVITELIIGYALPGRPVAMMMFKTFGYITMYQALQFTSDFKLGHYMKVPPRPMFWSQVIATIIGLTVQLGVQAWMFTNIEDMCNPKQKDGFICPSTEVFGTASIIWGVIGPQRQFSSGQIYYSLVFFFLIGAILPCITYAVQLKWPNSIVKYINFPVIFSGTGYIPPASALNYVPWTIVAFIFNYVIRRRHFSWWTKYNYILSAGLDSGVAISVILIFFALQYPLGGTIGQNTIMTWWGNTVGAKTADGMSAALLPIPASGTFGPATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFT1</accession>
    <name>A0A2G8SFT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_05339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFT1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFT1"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL32635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="278" mass="29772" checksum="F9ED82AEA549C4C4" modified="2018-01-31" version="1">MSKRKLDSIALEAHQPSKRLKAHPGDTSHHPEEAPRATIAASTSAMEMEVDPTTRPHSSQSTSPRETTKRAREEEEEDSSGNNDGQLSKPPPQPQHKHKVRKLVPPRPFPTVPASVSATGPRSAHTEGKNYICITRRTELGAYLRRCKDVFLKDGYKTLHLSAMGAAIPHLMQLALSLPGMLPFPADEVRTEVTTGSVEVQDEVIPDDDDEDVAYRTRGKSTVSVVITVGDGVDEPPPAGIAGKGGGRKNKLGKGRGPAASSGKQKGYGKRGQKGGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG53</accession>
    <name>A0A2G8SG53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05271</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG53"/>
    <dbReference type="STRING" id="1077348.A0A2G8SG53"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="454" mass="48900" checksum="45E54EB1A5588D75" modified="2018-01-31" version="1">MSISKFHKEPEFETLQLHAGQEPDPATNARAPPIYASTSFVFNDSQHGADLFGLRSLPCHSSLTNLSGLTRGYRALGNIYSRIGNPTVDVFEKRIAALEGGAAAVAASSGQSAQFMAITAIAKAGDNIISTSYLYGGTYNQFKVYLKRFDIGIKFVKSSDPAAFEAAIDEKTKAIYVESIGNPKYNVAALPELAKVAHDHGVPLIVDNTFGMGGYLIRPIDHGADIVVHSATKWIGGHGTTIGGVVIDSGKFDWAKSGRFSDFTEPSEGYHGLKFSETFGPVAFAVKVRVEVLRDLGSALNPFGAFLLLQGLETLSLRAQRHSDNALALAQWLVQHPKIAWVSYLGLPSHEFYKEALRLLRPNAFGGMLSFGIKGSDAKVGSEVVDRLRLASNLANVGDAKTLVIHPATTTHQQLSDEEQLASGVTPDLIRVSVGIENIADIIADFEYALRIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGG4</accession>
    <name>A0A2G8SGG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGG4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="138" mass="15418" checksum="1334E951B76CF273" modified="2018-01-31" version="1">MARYQMDAVDQLDQTQSIHRPVYVKDSTLRADDLPRRRSRGFVNAKQLLSHRELAARHRLHALDEVASLVVAIPSRLPTPIPSDDDPDPYREVDSVRSDPPRVEDSGELEDGDKVTMDASEENTGPPHLVSDVSGLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGN3</accession>
    <name>A0A2G8SGN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGN3"/>
    <dbReference type="OrthoDB" id="2757906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="63995" checksum="CE45C8C7F5F563DE" modified="2018-01-31" version="1">MYGAEPPSRLPANLYLYRPSWNVPRFTLKMLAKHEGYVLLPIVENLAIHGRISPTLTVRASRSPRRPPLVSTSPPWAPHCRPLPVQPVPPERANSTSCNKLWINAGEKPCLGAVVEGFKVFMAIFLAWDVTEPVISGGLRAVGGQLRGIRPTLAPAYDGEAFADFTWIAEGDLTSMSPSSSRGRRAQVSSPMRHPFDILQKAMSPDQLAFQAINDVKRLLTPRSVHTRSSTCVSVSLAKWAVPWVHDGDMAEETREELQDVSTPALAVALLSVSIGEFGCSTFNWDGCFSPLPVYMQTPLTPRPGADSSGPEALHVPTEVCENIIDMLYSNTGRDTLHNIAALHSCALVCRAWRVRSQKMLFYKVMLLEVTPLHKFAAVLDDGQHLRDYVHQVSLVGYHLHTTTSIFTLFAAVVSRKLPNLERIDVVHLESPATWCPRPPDPPKFKELPCIPIHPHFPAFLSTFTAVSHLRLEFITFRSFSEFARMLHALPNLEGLTCRSIDWLTPGGSHPGAGFTRQPDWEDGRCTAPPFAPKLRRLQLADMDKYGLERLIWTRGPHLTSLTLTIPLLIVECWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGP0</accession>
    <name>A0A2G8SGP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGP0"/>
    <dbReference type="OrthoDB" id="2802907at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="300" mass="32594" checksum="666E26B32E7EDB3F" modified="2018-01-31" version="1">MAPSITLSAEDLSSLFTTIYCGNSALTILFFDWLLCLDQEVACVWKARGGLNAGSLVYAFSRFPLMIGLVFNTVTIFPLSLSMLTLVARHSCRLAVWAGNSLVLLSRFSIGMFSAFRVFAVSGRKIIPTLGVSLLSTVPIINSLIMYGGGFTIVKVLPSPLYCSNINTLSSQWTFSILALLNVLQIILTAVSLDAIDAKESYVTIFIDPISSILTCRFILNLRQVSHSRMPSTMMSLGGDVHFAAQGSRSTLPRFVAPFGEPLHTDLVESEEGDEVDEVDEGSGNMYDSSTARDEVDMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHT4</accession>
    <name>A0A2G8SHT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHT4"/>
    <dbReference type="OrthoDB" id="10632896at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="423" mass="44125" checksum="CBC0FECA9DC46866" modified="2018-01-31" version="1">MAKDKNPVRQLHNNDPVNASDPADSGPGDDHPASSDPPVPVVVTHTLQELEHVERPIPRHTVGEIGSRLLCMAYLDEGIPNSIVSLCTLCMQMAIGEKPCPHGTFPDDTRELPLLLWRDDLIALVVEIVRELIRRGYLSRAQATASSPAAPTADPFANEDAGPSLSQAAHRRAFSLDFSQDTPRLSSPASDSPSISSVSSITSSTTSTVSVAETLVSDSASVPRGAGSNRAPAPTSPLRNNAQSQDPTGSAAGPSPGPLDSMDSFREILDEIRDTVMANLSSALTSLLASRLTPHAAQSGVQTAESVVHAVSPAAPLPASPASPDVPLIAPDVLSFGPVPSTLPQAGPAVLPADPAAPGVPPPVNAIYAARIDAYDASVRNWADTQRSTGGVSGNAFVGTRSYQEALRLFHDAENRGDVSQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI23</accession>
    <name>A0A2G8SI23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI23"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI23"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF5">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="95"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="260"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="486"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="826"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="828"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="914" mass="100463" checksum="0F6F448268AEF953" modified="2018-01-31" version="1">MSCCDDAATYVIKALGGEEVTKRVVGGTKWWQVRGVKGVDAEWIVAKKDYQEAKRRQKVRQMSMSTPSSLPRDGDDASQEMLPSYQPEMDEMRCVLYAHGGGYYFGSFDQERYSIQRLARKINGRVFTMNYRLAPQYPFPCAIQDFIASYLYLIQPPPGALHTPVSPSNIVFSGDSAGGGLCIAGLQVIRDSGLPMPAGAVLISPWCDMTHSFPSIHLNTATDIIPQFGLSFHKPSTLWPPPPDHLTTQVHQGLRQRVREAIRPRDKGTAKDKDKQAKTEVPVPEPLPDAHPAGLPARSSTPDYCLSDPSSGRTLHLGAAKPIPSPVLPGTIKSQRLELLTAEGEQLAIDGQVHLYTPNYLLPHPLVSPVVSYLGGLPPLLVIASDKEVLRDEIIYFAHKAANPEKYPVKPETKMLYPSLEGIEERYGPTEVHLQVYDDCAHTLPILFAFTTPGKFCFRAMSTFIKYVTGMLTKPSVDAPIILEDDNKEPPMTDSPASAPANPVMANGGPPRMTASLSEPLMKTRRSMPTLTASPEEMPSTPASAISPSSTSDVLPVSLISPSENRGKARHALSAGVSRASSFLRRRAAPADSEVPPVPGTPAHRSPAHESSGPDVAGPRWQFHKSSVDPQHRRAGEQEVYDNGLDTMIRERVSTHGVLRPLEPEEEMAAFRLPPEVIGEISELAVRRWMDGSAKFGKKFGNTTKAIEKARERNIERAKQDTVQNMAQLQAFLHEEYEKEKHQGEAKGGGKVKEGVAASGSWQWAWALDGDENPPPSSIVSRRDTEEARRLAKIADQAVFSEDQTMSGNNLWSLIVNFLTVTPERNEHKHHGHHDHHHKHAASEKSKQTQEGQSAPVSVDETRDSSEQLASVGTKATEKPETMSRREKIVSKFAWLVAESRKSRGAAATAHNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ86</accession>
    <name>A0A2G8SJ86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_03539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ86"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ86"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11306">
        <property type="entry name" value="M35_peptidyl-Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034115">
        <property type="entry name" value="M35_peptidyl-Lys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708299" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="212"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL33833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="36920" checksum="9FA4C108A85FD774" modified="2018-01-31" version="1">MFSASLRAALVLLAASAPAVSAVPGLSLQVAGPTVVNGVENLQVVATLTNTGDETLKLLKDPNSVLHTMPADTFAIATEDGASPSFVGVRLKYSPIQTSRSTDAAAFVILAPGASVSVTHDLSSSYDFTNTGHRNYTITAASNRFQFLGSNDELSEINATPGPTHTAALSGGLLRRPGLLKRASFNGCSDDQQATLLTAASSAQDYASEAASYLGAHSDGTPRYTTWFGAYDSAHHDTVQSHFDSLNGNSFSDFTYDCTCTDSTVFAYVYPDQFGTVYLCGAFWNAPSTGADSQAGTLVHEATHFTANGGTKDYAYGRENCQALAQSNPDEAVFNADNHEYFAENTPPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJF3</accession>
    <name>A0A2G8SJF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJF3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJF3"/>
    <dbReference type="OrthoDB" id="2753077at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="533" mass="57140" checksum="769929C9E51D5E62" modified="2018-01-31" version="1">MSGSSSTTSTATALAPSPRTGRSYDAHLFRPIPREVAPGIMDDGTLSAAHPLVHQFLAYTARKFQRLETDARAHTRRAAIFASAATAAKRWSKNTSKNNNKAKPKTKTAAQKERERARERAEVEAAVEHWHGQHKHPRVTRWRCMRGGVARVADVHDALGPGVTDRLAAAIFALAALSVYNSWTDPAHWAFWAVNIVEDTASAVHGVVRADPREITVPDHVAWVDAEMAVNVLRVWHGGFVPHQPKKSEAASDEEKDSDSDDGETSVKNANGKRTASDDRPATPTKRTRTKEPQNLAPTRQSARISMRKATQVEPAEREEMVVDVVECAAEPVASVELEAESEPVDAEPEDTVVAEPASAAYLEAEPDSQAQESQVAPSAKKSRSRPSRPRKSTGGRKPRAPRKPRASAGDRDIPSEPSLPAAPSPSSSSSCTIRIPARSSAGPVPALRELLDEVLSSPPQVISPLQATSGETTAAGSRESTAVGTPSSGLSTRVGTPLLEVEVKVKPIVVKPKVVPVRTSARIRAKSSASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJH7</accession>
    <name>A0A2G8SJH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJH7"/>
    <dbReference type="OrthoDB" id="3006153at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="187" mass="20269" checksum="DFDECE4F09C6D79F" modified="2018-01-31" version="1">MTSTSTSAEGWHARATPHPDASTFQPSPDALVFVSRMSTMASPDSFTMALFRPDAAVDASGRVLGLQPRDFATLALLADDVARLPDTGAFQGFWVVSSRYTCRANDYLHVKTVVTPKGEGGLGGLKTTGVYAWEPRHTELGLPTAGYEHLPPALHELVGYAREAYAEKTESEEGGELIRRIRAFVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJT4</accession>
    <name>A0A2G8SJT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJT4"/>
    <dbReference type="OrthoDB" id="2757617at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="62"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="621" mass="68909" checksum="30703D89138946CD" modified="2018-01-31" version="1">MVPSIIPSVEEVTTLLSKFNTSLDSAIRERSFSLEQVQDVTAAVARSLSTLHRYHNTLLPIGTLPPEVLIRVFDFVVSPPSDVHDVKPHKQAKWAIALTHVCSLWREIALSTSRLWSQIVDEDLNLARLFLQRSRSTPIRFYASLSMPPSEPNYIWQEVVQNYPHRVHELHARVSRMTPTEDFLNSLSTPMPALEFLTIQSNNPALLLTNPFPTPPLILGGQPLHHLKALILSRLAPFMPGNPLPNLVNLQLYGLGLGVLTAHNLLHLLANCPRLETFELLSPPAGLFFDFDERPTAQPVPLRALKALWMRDLHITPALALLCRLELPATTTVRLANLADVSQRYERPTFLLLPAGRRSPFKHLAGLTHLDILEDPHGAPGGGGASLYAPLYFIAHGARAAVWLHVAVTTGDAHARDRLFWNLLDMLPTEGIAALRVSARAPACFARIEWVLKRTPALTSLTLRCGDAQVLSPPAAVMRWQNPALKKPRTILDDVASALAPRGSGSAAVRVSVPLLRALAIEVGGTWDADLAHGLVRALAARKLCGHPLRSVACGAKRVDDRALAERLREQVEIVKVVERKLWEVVGISAVWMVENDYWSLYLRESRYGWELPHDTYESNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLM0</accession>
    <name>A0A2G8SLM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLM0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="115" mass="12487" checksum="7F99E9E263045D1A" modified="2018-01-31" version="1">MTSASSSSESLFSESLFSESLFSWCPPFHSLTFHAVAVRITFTAPEMSLTISRRSGAGTSSQPTKNCMLSDSKTTPLSPRYRKQSRIASNVATVLVPETRNSLRFGQATTESACI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM20</accession>
    <name>A0A2G8SM20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM20"/>
    <dbReference type="OrthoDB" id="2741929at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="79274" checksum="D25160FE9FF2840F" modified="2018-01-31" version="1">MDPGNTTHDLSFFLDGVVRTTTDLRDDNLRLKSKNEHLEGQLSEVMPELEKLRKERAALKAAIGALLRQNGVLPAHGDDRHWRTPATFATLPHEILQHIFNLAVSTEPTYQFDPSIGPGAHNPWFDLVRMKKAFPLICRASVWPGMAVLFSDIVLRRMGQVSALAETLRIPDVGPRLGNLVKGIQWDSCLVTAPCSDVIREDLTFIFAQCTRLRSFSYHPHTSFPLRSVTPDEDECEGCFNPLWFITMPPSIPDHPLLQTPTFNLRRLELDLSMDDAILRAIHKILSTFNALESLALGPWPAYPSLLLEDSELMKLAAVSLPSLTNLQIFATSAALDQYLCTRWEVPQLARLTIIFCSGWPSQLLGQFGRGLRYLHLFPTPSVFSNNQTFLPSLQACSTLVDVCPVLEHLVVPLLEKSLTSYPLPLNSPTLDEPTAAMYRRSALNPESKVPALRTVRLLFTSEKAVPSLVGVAGGAASGSGVRSHVRNPDWPWICHPRLLVEGSADSDSVLYYYFAQGWVAQTGAAVIPQDLVPLVWKGRDFDDGWPAVYGHCLEDSLLDERAGDVEGEGGDGARSGDENNTTVIGDDDDAREKEEQEEPEPKEREPEEPEPQEQEMVEAAAELALPEYPVTQLDRETVLTAFRSSPGSPIVILTFGITISGLFTLYSGRAKAMELGARYRSCAGPPRPRRHRSLARPVGRAQAGGRRMYLLHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM52</accession>
    <name>A0A2G8SM52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM52"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="159" mass="17255" checksum="ED13AF5CA474BF2C" modified="2018-01-31" version="1">MNCVADPRDCPRPCRAQVATGGEPPTPIPIPIPNLASVLARPDAWTRTMNVALRYQARRARKIRVAPAEPLVTVSARPPVRLPNSFQVSSVSPSPWIRVARTCLVRLIGARGLMHMPHTQIPSTSSSAPAPAPPRVFRIHCHLLQLEGHACVPVANRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMJ4</accession>
    <name>A0A2G8SMJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMJ4"/>
    <dbReference type="OrthoDB" id="2766701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="149" mass="16269" checksum="10260BBEC22B8098" modified="2018-01-31" version="1">MWGALASLRLWVPVHPHERHISDCVSLVPCGSRMPIVMFDDAGCTRASVYVFDINPFVARQTPQILAAQPDSGPGAIATAIVEDVDAALPGIVDPECSASPFVVYRFGIPLPEVEHYAWRMIQAVRMSMTGFTVTFGDGPLETDHTWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMW3</accession>
    <name>A0A2G8SMW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMW3"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="181"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="330" mass="35799" checksum="E4E028FFD8659DF9" modified="2018-01-31" version="1">MDSDSPVLLTLSSLIVSRIKEALGCGIVALVVSTGVYGITILQAYIYFRSSGKDSGRLRSFVALLFILDTTSLVLAVDALWEYIVTDFGETWLLLQLPRVLAFENGITYLIATLTQCFFAYRLWGLSRGNVLLVTSIVILSFVSLGMAIVVCVRNYTDPGFPELATLEMRWLIGLANGLSVPCDVLITVGLSYYLNSKRTGFKRTDSIINRPIIYAVNRGALTAICQAGLTIVFIAFPGHLFHLPFDLLSGKLYCNTLFATLNAQKAIRVDGDNVMEANSLVLNLSRANAAAAWNGTGQRAPSERTGDSTLTGSLKIMGSERMQAGVSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN08</accession>
    <name>A0A2G8SN08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN08"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN08"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="321" mass="35504" checksum="F27E4EC13AE8E047" modified="2018-01-31" version="1">MGNALSEFQKKLPALAQIYPPKSKFSVDQIPDLTGRVVIVTGGNTGLGYETVKALLQHNAKVYLAARSKEKADKAIASLKEETGKEAIFHELDLTDLAAIKKSAEDFLSKETELHILFNNAGVMFPPISALTKDGYDLQWGTNVVGPFLFTELLMPALIEGVKTSPDHHARVIIVSSSGAYGNVLHWDTFKDTPERLKSTPQGLYYQSKHANVIVARQIAKRYADKGIVAISLNPGNIKTDLGRYLPSLTNKLMEMTILYPAPQGALTQLYAGTMPEALNHNGEYLIPWARLGKCRPECYDDAIGERLWTWLDDEVKPHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN14</accession>
    <name>A0A2G8SN14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN14"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN14"/>
    <dbReference type="OrthoDB" id="3209295at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="59"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="610" mass="66872" checksum="02AA30D02660C079" modified="2018-01-31" version="1">MDAINVLNDVQSASTRIQRFTRPDAKTQADYIETLRQLSTLLTDSSSHVRSLLNAVATINTLPPELLAHIFTFYATETVRIASISIFEAYEPFNYPSPRAALRLTEVCKHWRDVSLTSPSLWSGVICGGNDATPTTRYLSRSKSLPLHAIIKGDLEAVEEILDAYPSRIQHLLLVDSNSWTRRYDPRRLLINVAPDLLTCTLDLHSWPRGPSLPELGYTLFSGGASRLRTLSLHSVKLIPLDSLPNLRSLALYHILGIPSLPHILALLGRCPALEDVCVHSNREPARIALDARFEPEVVELRHIRKLALLMQNSVWLLAHLSIPASALVRVDDITLLQMAEWPSLPPPPEGTASGVLANRTRGGPLTRMRVSSPQGSPIHTGIVAELRIELAGSERGSGVCLNTAAPSSTPRERYGAAVQTVIKRSAPLFAHVTVLWAVRQSALLWPILFDLHELRVLGIVLGDSDARRLGWLTNMNMRTIASSDKKVVCPALETLCLCDFQGPASELQHLHRMVEARAQLSRPLRRLALECQCKCGEGDGDGDGAAHLAAIRAHVGELVVVSRGPAGSAAALPREWREELGWADNARWPDWEFFAESHGGSRGGSVGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN83</accession>
    <name>A0A2G8SN83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN83"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN83"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="45"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="301" mass="33278" checksum="A5037589A34BA01F" modified="2018-01-31" version="1">MSFQLPEPQSNQAYVEVSALEAGIITMPLMIVFQGAGPKDTSVIPSLAFFLRHKQSGEHLMFDLGVRRDTEALAPRTQWLIKNHMPVEVPQTVEESLKKGGLHPEDVQTVILSHLHYDHVGRPESFTNAKFVVGPGGRELLEKGFPGNPESDILTSTVPLDEKRSRFLTHEEFNVSIGPFPRAHDYFGDGSMYIVNADGHLAGHINILARTSASGSWIYLGGDTAHDLRLLTGEKEVAEIVTPDGHKHCVHADKEKAIEHIKRVGSLLAVPKVHVLLAHDREWYEKNKNGDAFFPGVIPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNB7</accession>
    <name>A0A2G8SNB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNB7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNB7"/>
    <dbReference type="OrthoDB" id="2791290at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="153"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="524" mass="59224" checksum="99F3599023784D75" modified="2018-01-31" version="1">MRTHREPTPVISSSSSDDEEEEDMGSDPIPAFVLPQPESPAPSPDRSDPDDDDDDDDDEEEESEEESSGQSSDEVEGVLRAARTDVAQLCREGGASLIQFLIAKAIPPDEGEKVPPANVREWTYRDIASLPNAERKEWFTACREELEALRRRDVYDLVDRPKGRKVVKNRWVFDVKTDGRKKARLVAKGFSQVEGKDFDKIFSPVVRFETVRLIMALAALEDWHISGLDVRSAYLYGKLDEEIYLEQPEGFRISGSEHKVFRLKCALYGLKQAGLAWWRTLSESMKLMGYKRLTNDAGLYIYKRHSDGELVVVIVYVDDALFCGRDKKLVALLKAHFMKKWECRDLGDAKEFLRMRITRIGRKIFLDQRAYLEKVLDRCAMTNARPALTPLPAGYIPAPNTGQATPELRSRYQKVIGSLLYLMSGTDRIWAFAVTKLAQHAANPTEDHLSKALHICRYLVRTKNYALVYNGDSQLGLIAGTDSDLGFGPIHSTLANWLYAEVSELCILVGFTCTEDHCPLLHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP69</accession>
    <name>A0A2G8SP69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP69"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP69"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="503" mass="54687" checksum="9C777EFF17D55454" modified="2018-01-31" version="1">MHELCPASIPALSLVMPRPPLPRRRSSLLTSVSDPHTPPPRNSPLPLLTPGSNRKSSDSWNSSNYDGADDLEWEWNSEQTRLLSRTLDALPAHVLTPFNGPVPPSNLLDKIAKGVMRAKGPAEWPHSIRATRAKIIELARIRAKEDTASDTIAEEDSTDLDSSQQKRGRGFKRPLHKQSSMDFLKPSKLDSSDTIARLSYRLQHTERMIPNPAYHPYARPSPHLRSGGSSASSTTLNSQSSCGSVSKMPRLRRSLSSISNSSDSYVQTPGLDSRVQHIRRTESFAGSALYPPGSPLKCVPSFGSISKRSSDAMSVDYSNRSDVTSSSDEEEKLRSKKAKKPRVKASSPTPPISSPPPTSHAKSKQLRRTTKHISKTPSAATPTDTPRTSRQKITLSRNPSILGPELPHLSQARPTPPIPAAQPRSYHKSPPAHSPLSPVPRAATVLQTPSPPTRKTPRRTKAPSSGRAIVGRKISFGNVMATHDEENACLGAGLGLESAFQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPI9</accession>
    <name>A0A2G8SPI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPI9"/>
    <dbReference type="OrthoDB" id="2589196at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013802485" description="Transporter" evidence="2">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18111" checksum="92C09A0459F4AB3B" modified="2018-01-31" version="1">MFMATVAALVLLYVLQPVQMASQNLTTRSIRVLVTFSTPFIQQFYFLRSSAEGGIRYGAWIPSQPAGGQTSPNAANTLSCRWPYVLFALISTLAFLASAAALGVALYLFTVTRDRFHAQQIEAAYGPSLWLSVAATAVLLVVALNAGCGTCVGGRFGRQPRHLHYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQI6</accession>
    <name>A0A2G8SQI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQI6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="111" mass="12239" checksum="82F5CDF377565479" modified="2018-01-31" version="1">MSSKRSRPADDRDAKAPSAKKTKIPFGRLDRRGQVIDLSIPVPKLEGSMEEPITDHDELMKLLTASTRQILTLLENAMKNLKGHAASAKKTVSNATKHLRVPDDDGFACKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQS3</accession>
    <name>A0A2G8SQS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQS3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQS3"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="2">
        <location>
            <begin position="188"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="264" mass="26866" checksum="9609DB5F14EAFA15" modified="2018-01-31" version="1">MSVTPGKGRLSAIPTPGKPGTGTGIPTPGLRPRSTSSTGQRPSSNNQDDDYASRAFQDAIRANDPAQHRAPRAAESHPPSSFASSLSPTSSASSASIQSLGLGFSTNGARSSSLVASVGGVRPSSSASSASASSAGRTPSAKASAVRPPSRSSDIFARSASRAGRPFDVGDNVRIESLGFEGVLKYFGEIDGKPGMWAGVELSGGFAGKGKNNGSVAGDPRIQPSSKGPSTVFKKPGSSTSLAFLRSPQWLSQLFSVVSSHPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQZ6</accession>
    <name>A0A2G8SQZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQZ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQZ6"/>
    <dbReference type="OrthoDB" id="2791547at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013641201" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="62649" checksum="712A1B52CAE753CA" modified="2018-01-31" version="1">MFSSFRALQGLLVLASVCSPVLSFPTTTPARLSARALSKRNIGDYIDNLIYLDANKTSIYSAISINDQTYAAALDNHWSGLLVYGDNFNGSTASLHNITVEGVTIDVEDGRETIGLLEEDVTLEFFHVPQWPGHLPRMSYNGIESAYWGIDINNPMSPIFTYFDAKWPWDYTKWFYDIVIFYDWLSDESKVGIDFAGIIVAGQTVDWTKVLDITQEQANSYGLPNLDGINSQNEIWLNADGTFYLDNTVWLNGQQTVINSSVPQTPSDKYVGDIYTDTRWSTYPDDVVNGLYNITGAKYFPDSTFGYYQIPCDSKVSFEFAINGTKYQVAEDALIAKNPWGDQCIGSIFTKGQAVAAVPEFDVKIGFQLLSSFYFRAGVNQTTDQPYYKLLALPEPTWEGYTSYGYPGQTSTAAQSAPSNVASASSSATSNASTLTLSPISAPSSSSVSTYTSNGAATVTPSPSAAYTSSAAGSSGTPATQIAGNLADTDGSSSSSEDFWRHRAQLFEILLIVFASLFGLAVLGGVAMCVFGNRGQKGRPSAYRSIHDTETSGTHAPLYGAEGGQSRYADPYHDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR76</accession>
    <name>A0A2G8SR76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR76"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR76"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="5"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="303" mass="33294" checksum="7744A5831C2972FE" modified="2018-01-31" version="1">MVTKLRVAICGGGIGGLTLAVALSRYPDIQVDVYEAASQFKEIGAGVMIWARTWEILSLLGMAEAFSCIAHAPPDGSLGVGFDYRKSDQPQVGSRFYLFEVPYGCIRFHRAHFLDVLVDHLPAGVAHFGKRLTSYTYSSDMPQIRLQFEDRSSATCDLLVGCDGIKSIVRKQLLEDLVHKRGGDPRLLTHIEPVWSGTIAYRGLIPVERLRNADGTEHRTIRSPMMHVVSYSISAGSIVNVVAMVSEPLLYGTEFTGQWVTDCSPSEVQECYGGWEPEVEEMLKVNHATLQSLQMGVTGPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRG8</accession>
    <name>A0A2G8SRG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl hydrolase family 92 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRG8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRG8"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000001">
        <property type="entry name" value="Putative alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF43">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573939" description="Glycosyl hydrolase family 92 domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="272"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="743" mass="81863" checksum="9D1F431BB0EE76A6" modified="2018-01-31" version="1">MARGSLLSLILLVVVASTDRLHSRRAPAAFCQPPSKAVDHVDPLIGNGGYSPNGSGGMIPSTAPPFAMTRWVAQTRLNRDSITLYNYSDTTIHGFQGTHEPAIWMGESGSAIVVPGAGTVRSKFEDRGMNFAHANETSSASYYTVVLDAIEGGTIRTEQSATSRVGHMRFTFEDTQTPYVLLEATRAQVSAFLNPKVLTYPNGTITIDPAAREVSGSNPDRHNFVVDPSHNKTIWSAFFVARFDQDFASYGTVQNGTITEDAKVGGGQAAVGARANLDKEIPDGTSLERTAYNTRKQWAEKLDRIQIEGASEAQLETIYTEVFHTLQYPSEQDKDGKYYSGYDNQVHSGNSYTSYSDTFHAEWAWLMLLTPERIPGMVQSMLQDYKEGGWLPMWKNIVETNVMIGTHSDSLVAEAVFKGFRDFDLDTAWEAVHKDATVPPNNDVTTSYYDRQLNVGYEVRAGLSSVYATKGWVATDIHSEAASRTFDYAYDDYAVSVLSTALNKTDDAEFFRARALSAPWTIFNNDTGFMQARPSNGSWGAVTAGWAEGDKWAYTFDVVHDVPTLIEKRGGNQSFVNFLDEHFNGGHNDHTNEPPHHIPYLYSLAGAASKSQERIREIATDNYNNSINGLQRSLWRAVIHLSNEDCGQMSAWLIFSSLGFYPVNPVSAEYVVGTPFFDKITIDLSAAKHPLVVTASDAPKNPYVHSVTVNDIDIASGGHINFKMSSTPQSWGSGTLAQNTTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRX9</accession>
    <name>A0A2G8SRX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_00215</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRX9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRX9"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="314"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL36526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="797" mass="85363" checksum="438DD5F139A760A9" modified="2018-01-31" version="1">MPPGPHQSGPPPSLLYDPSHLTDTSPPATTAHGHFETPPSSPRLGPQDDHLGSLNPPSANPDAPHLLTPYPLSSTARTDNGLRNSGPSASPASSGHILSEKPLENDAHHGEGASLVTHLDKDRTRSKRKRYIWLAVGLLVIIIVVLAIVLPVVLTSKAHSSSGSSSSSSSGNGNGNGHGHGGSPGSPNNPESPTGAVTGGDGSVVVMADGTSFKYTNKFGGFWVDDPRNPFNNSARAQSFTKSLDEAWDYSTDQIRGVNLGGWLVLEPFIAPAVFEKYQNVPPSAALPGGDVHDEWSLSVAMLNDTSTGGGIEQLEDHYKTFITEQDFAEIAGAGLNWIRLPIPYWAIETWPGEPFFARKAWDYVLLAFKWARKYGLRVYLELHTIPGSQNGYNHSGRMGTINFLNGYMGIANAQRTTDYIRFITEFISQEGYTDVVQMFGPINEPLLGIIGRDQLTRFYLQTHDMIRGITGIGKGPYIVIHDGFQADSSWKDFLPGSDRIVLDTHPYVAFGGDFNHPLTYWPQAGCIAYGNNQSQMDFGITISGEWSGAINNCGKWVLSVGQESTYAECPTWDDWQNWTADMKTGIKNFIMSQMDAMALPGYFFWTWKVGNSSVTGKVEAPLWSYKLGLENGWVPDDPREALGICQSLGFLRNLPWDGNYKSWQTGGTGAGTIAADVVAQYSQYPPPALSNVAGANPAQLPVYTATAAPVTLPPPQFTAATVSMGNGWADARDTESKMAPIEGCVYPNAWGPDGTSTALVCNGATAHIGGRGAPAATVAAAPTAGLAPAPTSAPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS51</accession>
    <name>A0A2G8SS51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00286</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS51"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS51"/>
    <dbReference type="OrthoDB" id="2763996at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="607"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="644" mass="70716" checksum="5616DABBA04B6B4E" modified="2018-01-31" version="1">MVPHVGPTRLLEFLSSNSHPEDSLATAALTISFILASVFDTSFRTVSITVLVLTLPSTRVIASLIFSAVRFVLLSVHSLVQDLCLVISSTSLFQAIAHYLVKATPILLLLILIILATWSTLSGFYPCEVAESTAPSTPRGPPRRSPMSFRRVRGIPVLKLPPDQTPTPCRERERRYLEIIDARDAKISRRAKRIEKLTLRLDQAREVVAARDATIAEKERTISENAAALAERERTIAEGTEAIAAKDTIVARLTEDVEHLRSDNVDAVSMLAKKSAHISDLCLQLATTSAVEERRKAAVDALHARVTALEADLSAAQTEAVALRAASSEKTVVPMEDTISAREASVVVQRDELIASLHAEILKLQREHDSLHCRIVEKEALLATQTATIDDLREEQDAAIRSAEAQTQLVEHLTPMVTTYEQEAANPSLAEHHLPPASSDGLETRTVTLDVDIRSLTQQLAAAQQEALEATRLQKAYEEVADAGAVRVIELVQQLEEQKELSEVDRELFLVRIRKLTVLLDKARSGIPVPDKAFAQLRLPANTRSARTEDIFTAVTPRLPAYTRSPSPSRSLQNERKLRRRSAVENLRQPLTDVTASATANPVPLGRQPVPRSRLPRPSSISIPVTVSQSPPAVSERRPDISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS63</accession>
    <name>A0A2G8SS63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS63"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="11839" checksum="04E45ED853ED6E90" modified="2018-01-31" version="1">MRGPRVPGRCDSERCTDGVVGAECDDGVFVGDGGRRSGGSPALSNKPCVSTGALGVKGSPRAAPHGDEWAKLADGGPGPDRGPSTVTSGVRAKSGGPLICAIPVGKEVVDAMVGATGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS97</accession>
    <name>A0A2G8SS97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_00335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS97"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS97"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL36646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="27526" checksum="FD1F02FBA916352E" modified="2018-01-31" version="1">MGRVIRAQRRSHAIFKSHTHHNKAPAQFRALDFAERNGYVKGIVKEIIHDSGRGAPLARVVFRDPYRYKLRQETFIATEGLHTGAFVYAGKKAQLAVGNVLPVGQCPEGTIVCNVEEKVGDRGALARTSGNYATVIGHSPDENKTRIRLPSGSKKTVSGSCRATVGIVAGGGRIDKPLLKAGRAFYKFKAKRYNWPRTRGVAMNPVDHPHGGGNHQHIGKASTIARSAVPGQKVGLIAARRTGLLRGTVKVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSD4</accession>
    <name>A0A2G8SSD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSD4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSD4"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="392" mass="43580" checksum="FF391A65175181F4" modified="2018-01-31" version="1">MSSVKAEEGHNLDQSLFGNLHIPPNYRKYDETAETETVVQLEEWKRNAYGVLCKLRDDLRALESVNATYQADLVYYVSPFDGDGPWVLDSSREVARDILTACTKSTADVQGRVLRNFVKPIFQPNPHPSVNVETGRKLPRAAGGPLNHLDFMEGQDWKNNPGVSHVIYWCLSHVDTPTVEKLWHLFIPPIMTLLDDYEAKYKLLGVQLVSQLLEVSPPDLLQRTGIDSLILHSLKTCLAFLQHRETPSLIRSAVPTSVRLTEITTAQGSAARFDQLCALLGDNIIGNIWVYASRDSDALQASVDVIPIIVKALGVGTSRYLKGLISQLVFPLIPAPDNGASVEYKLSSLKALRVVIEECAPRIHKWRGAILEGILKCWVDIPESNFNAEGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSH4</accession>
    <name>A0A2G8SSH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">General negative regulator of transcription subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_00414</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSH4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSH4"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex, subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="13">
        <location>
            <begin position="604"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="332"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL36725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="733" mass="80771" checksum="1085F7E2FCF66220" modified="2018-01-31" version="1">MAARKLQTEIDRTLKKVGEGVELFESIYDKMQASTNQTQKEKLETDLKTQIKKLQRLRDQIKTWVASNDIKDKSALLDNRKLIETQMEKFKACEKEMKTKAFSKEGLTQSAKLDPKQQEKVDTMTWVQSMLDELMVQVESAEAEIETLQGGGKKKKSGGAAAERLEGLEKLNERRKWHISRLELILRLLDNGSLATDKVISIQDDVKYFVDSNTDEEFEEYEGVYDDLNLDEEEEKFRMPNDESDSEDSEEASEPDLPLRTPSKKHDEESVASSNKRDSPVLKKAGMTLAQRKQSIAAEPPKPPPHANFAQQSVASMVKGPAPPRNPPSGYAKVAAAAVAPSSSQSHSTVSTSVSQAAIVPPTPSASTTTTSTSSLPPDQHSAVTSSPILTHPSVTSPMLSSAASVSHQPDDSVFSAHGSPALLDAVPSSIGGPAATSSPQRPIARKASLSSPTALQPPGVPHPSQDQSSAPVSNGLAPVSTATVQAPPTPSPLPQLGQTFPTTPAPGASSPMPLPTRPQSQQPQFPPGVVLNNVDHAKQAQAAPGARPPSTSAPGLPSQMQQRANAFPGSLSDLVMSFENVKQKAPHRMSNLDQVHKLLQGSYTSMPQPQDTEKPKYYVPRNPVQTPSYYPQVPHPLLNTPGIFSQLDVETLFYVFYYHPGTYQQYLAAKELKRQSWRFHVKYLTWFQRHSEPQAITEEYEQGVYVYFDWEGSWCQRKKSDFRFEYRYLSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STH9</accession>
    <name>A0A2G8STH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="4">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_00762</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8STH9"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000002">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="13">
        <location>
            <begin position="883"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="766"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL37070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112062" checksum="87D2B7A02246BD44" modified="2018-01-31" version="1">MSASNLPSAMDVDEAAIDEGLYSRQLYVLGHEAMKRMAASNVLIVGVKGLGVEIAKNVILAGVKSVTIYDPDPVQLSDLSSQFFLRQEDVGKSRAEVTVPRLAELNAYVPVRNLGGQPGQEISVELVKGFQAVVLCGVSLKKQLEINDWTHENGVHFISAHTRGLFGTAFNDFGPRFTCVDPTGEQPLSGMIVSVERDQDGVVTCLDETRHGLEDGDFVTFSEVQGMAELNGCEPRKITVKGPYTFSIGDTSVLSEYKTGGIFTQVKMPKILQFKSLHESLKEPEYFITDFSKFDRPAALHAGFQAISQFEEQNKRSPRPRNADDAADVVALAKQIDADVEEKTVIQLAFQATGDLAPMNAVLGGFVAQEVLKACSAKFHPMLQHLYFDSLESLPSDLPSEQDVQPIGSRYDAQIAVFGKKFQDRIANFREFLVGSGAIGCEMLKNWSMMGLASGPNGKITVTDLDTIEKSNLNRQFLFRPKDLGKFKSEVAAAAVAAMNPDLEGKIDTKQEAVGPDTENIYDASFFASLDGVTNALDNVKARQYMDQRCVFYEKPLLESGTLGTKGNTQVIAPHLTESYSSSQDPPEKETPVCTVKNFPNAIAHTIEWARQQFDALFVKPPQAVNSYLSEPNFLETNLKYSGQVKEQVETIVSYLVTNKPLTFEECIVWARLQFEEQYNNSIRQLLFSLPKDAVTSTGQPFWSGPKRAPDPLTFNSSDPTHLQYIISAANLRAFNYGLRGESDPAIFRKVADEVIVPEFTPKSGIKVQINDNDPAPQGDAGGDADPQESLKQLPPPSSLVGYRLNPVEFEKDDDTNFHIDFITAASNLRALNYNIAPADRHTTKQIAGKIIPAIATTTSLVTGLVCLELYKLVDGKTKLEDYKNGFVNLALPFFGFSEPIAPKKSKYGETEWTLWDRFEFKNDPTLKEIIDWFSREHKLDVSMVSQGVSMLWSSFIGKKKSEERLPMKFSKLVEHVSKKPVPHHTKHLIVEVMVSDEEGEDVEVPFIVVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STT3</accession>
    <name>A0A2G8STT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CcmS related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STT3"/>
    <dbReference type="STRING" id="1077348.A0A2G8STT3"/>
    <dbReference type="OrthoDB" id="3171339at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058258">
        <property type="entry name" value="CcmS-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26617">
        <property type="entry name" value="CcmS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CcmS related" evidence="2">
        <location>
            <begin position="506"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="701" mass="74952" checksum="CCEA508E06F1B745" modified="2018-01-31" version="1">MAKVKKNKAKGPDQVAKAQSAQASVEPAVGAAPPAALHPSSHAVVGSMAHEGNGHGGWPGHPQGTVEEAEEDDGWGDGADASGAVWEQPPNDWGTVPDNTWGNTPVNDWGSTPAAPGGWDEPVADDRWGSSPAVSASGGQGGHPTGSRGRSRSRQGGAQSNPQPTTQQAARAPANTHSLHPSAHAHQMSPAGWGPTVDAWGTEPPRPSWAQPAAPKPPGHKPAWTKWASEAKLVNTPPIHATPAPYDYATQAAALGGGTRQVLSEQQRSQILSSLLEAPQQQTKGYSPQSPPQASSHPRQQPAAHPGQSQTYMHAQFVAEQQGILRSIQEANMHSNGHTQRGHSQQPRQGLQYADSWTNWGRDAYGGERASTIPEEDEYEDDGWGDTEDEEEEDGWGQSHGYDNNQRVRFSSNVSYAGTPSIASRTPSHGAAPASGAIPPRQRVPSNPQMWTASPNASRTMRIATGTLSPTPNTTVKTTVFELPPPRNGFGENAFASSHGEALVPALRAMYNQGRPTKERIRWGFNPDKDPRVGSLLRWIAAMSNGLAEIGLQRFLDTQERGALFANADFRVPATHGSVTQPAFDWVTLTELQNTLDSTLQSSVTLYDPAYQVIVFVFLLSPSGNSMAVWRRKLNVPDSLRGTYEGDILAVKAGLKTSYPVYVDELPVKPAAATPTAVKKKKVRFAFIRRIFGGGKKAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU70</accession>
    <name>A0A2G8SU70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU70"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013936823" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="428"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="529" mass="56001" checksum="BBD89AFDC4B9C9DF" modified="2018-01-31" version="1">MHLRPHLLAAATIAPHLVVSSAVNVSVPIAPPSDSQTLSRTLLSFSIEEDRWPEWSGIDSRNDFAYNALTTLGNLTGQPPKLRVGGDSEDHTFWSPTVAINEDQFPSPSTNMPYPEATHITVGNAFYELVRFLPRGTHMTWGINLGADNATNAANMVKAVVGAFATDSVKDSGVILDHLEIGNEADIYTFTGLRSGNWTAEAYVSDWISIAGPAVEAAGIDGPDGPVSVQGAAFVVQFTPTEIFDLGILDSAPGKAITQISQHHYSVTAFCNGSDISLASFMSKEAVRSNLTIFSADIAEVHRHGLTYVLGAQTLTATHSETSSVACHGAPGVSNVAGAALWTIDYALQAASLGITELFFHEGVGFTYNFFQPVSLNRSTTDGSPLDPPAAPHIQAPFYGALVINSFIGSTGSSKVVELDVGDSNVSGYAAFENGVLVRAVFINLDAWLVSSTGSRPSVHVNLDFVGEASLKRLVIGHADDTEGLIWAGQSYETSDVSPKGTLVTEEVLLSGGFDIRSTEAVLVEFGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUJ2</accession>
    <name>A0A2G8SUJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_01143</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SUJ2"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000035">
        <property type="entry name" value="PHD transcription factor Rum1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000016">
        <property type="entry name" value="Putative Lysine-specific demethylase 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="17">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="16">
        <location>
            <begin position="312"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="526"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="18">
        <location>
            <begin position="687"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="408"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1716"/>
            <end position="1998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="423"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1752"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="1823"/>
            <end position="1835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL37449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1998" mass="223320" checksum="428D8F62E869FCAD" modified="2018-01-31" version="1">MASQTGVRRRGGGRRLVGGGGEGEGAVGGVVYVAMSPAIRRRQDRRWELDSAKAEVPTWKVSGLKDRSSGRNRGEHSLAAVSSFLSFSTAAMHGSPSPRGGPARRGRSPRTNADSPAPPALPPDFSVRSPATFTSCLTIAVEGAIPIERPEPAPVAPDAATSDSNSRRAPRKSKTDALAALHTHAQSNAGEEALADAMTEDGGIRIQLRDGPPLPVPATLDLSSVKTPHTRPSGPKAAPRLFGLTDCPTFYPTPEEFKDPMAYIASISDTGKKYGVCKIVPPPGWNMPFVTDTERFRFKTRLQRLNSIEASSRAKVNFLEQLYRFHKQQGNPRVSVPTINHKPLDLWSLRKEVHKLGGFDAVTRDKKWADLGRLLGYTGIPGLATQMRNSYNRVILPYEQFCERVRNSPALSPSKPRDPGLKTHTNIQTSTTLPQLSTAESAADDDSPPSSPLTATSSPLSEPPDESDMKETNGVKSDASRPRRSTRNTTQDLLPLARTSRTSTGNDALVAGQMDPDAPKKKLPSELHCEICLKKDQGERMLICDGCDCGFHMFCLDPPLANIPRGQWFCHNCLFGTGGDFGFDEGEEHSLSSFQARDREFRRLWFLSHPPQSGMFNGTDSSSSARVGDPYANRFGNMVVTEDDVETEFWRLVQTPTETVEVEYGADVHSTTHGSGMPSLETHPLDPYSKDPWNLNNIPILPQSLLRYIKSDISGMTVPWTYVGMIFSTFCWHNEDHYTYSINYMHWGETKTWYSIPGSAAEKFEAAIKKEAPDLFEAQPDLLFQLVTLMNPQRLREAGVDVYACNQRAGEFVVTFPKAFHAGFNHGLNFNEAVNFALPDWLPLGLDCVRRYQEHRKMPVFSHDELLITITQQTNSIQTALWLNDCLQEMTDREMDARTRARSLQMGEVLEETDRADDQYQCAICKVFLYLSQITCPCTTRVVCIDHVDLLCKCPPANHVLRKRFNDIELQDIQARVSEQAAIPTIWRNKLKKLLDESPSPHLKSLKAIFAEGERIQFPLAELNSLRKCVSKANEWLEAANTIIARKPARKRTRKSRGRSSTATVDGLSSDVAEEVIEKPDRTLDDLYGLLDEVANLGFDAPEIGQLRQIAREAEEIRGNAKDLLARERSARDREGFVHECRRLIVHSATLNVLVDEIVEVDKIVLREQLLKDLVVELEDENLSLEDIRQLKARADACNLPMDNLQMQRLYGLYKSGMAWEDKAKRLLEKKDRSLDELEEFMQPRRNGLPFDPEILERIAELRKKGREYEKQAKIWLLADARAEKPKVQDVVKLVADAQRDFVIPAVQDLQRTVAWAQDLEGRSEAVLNASYSGIDDKDIFETMGTWRDYAKKHLTMFSLTNFQKLETQLELHHRWIQSLPWYCAQHKDTHGQPILDDVVESTRPEDDLPPTDEYFTCICTTPVRPPAMGQVSDAVQCDHCFARFHGVCAANGGSCPFCDHHHWNGTIHKERSWHFCYLPTIMMHAPDISKCYSEEWKQLEIIVHRVDRLCGVIGQFLSFLNQPANQRVEYIPQVRHYMRKLYKIQFAVSPNPEVSFGLELASLHRVLAGQPAPTRMKKRRRPKFTFGQDQDKDWLDGTRCICRGRTNYLLNYPTVECELCGKLYHGGCVFFPVEGGRGARFMCPLCCVRKNRVYPYSEVRVKHVENPEQDLFVDTKEMLDTFSKDIIYMRLPPPYTQTLFVELLRFTPGQPDNIAANGASISAPPTRPMSMSGPSNPAPMPVTNGSSAHPRSMHPPHSHHSHSHSHSQSHSQSHSHSHSMSAPPPAGPSYDNGRPPSHVPPPPPWALTLTSRWSSAAAAAAPPGPSRPAPPPQSPAEQMRSPIGGMQTPPLASRKRKYPEEVAPPHGPPPPDDRLAPAPLIRSPKRHHSTTVSPPQPSAAPRSSQGMSPSLAMMLSPTPSADMRSPTRQQPPPPLPTYVHAHSRSIPPSPGRSGPTEDPNSHHRGQKVKAIYPGQSSAPPRVDEERWSPSLPPPPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV55</accession>
    <name>A0A2G8SV55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyoxal oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV55"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV55"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013593976" description="Glyoxal oxidase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="76"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="442"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="58868" checksum="76366EB14937B0FF" modified="2018-01-31" version="1">MRPLSKSKFSLLPLLATLASASPSAPAAPGWQFSVKGNSGIVALEAVVVSPTLVLLFDRAQNDPLQIDGHPAWGGLWNLEHNNITALEVVTNSWCASGAILSNGTMASIGGDQTGFPGNPAIKPGNQAIRLFEPCTSPVGAGCTVFEDPNLVLIEPRWYPSSTRIFDGSLLIVGGMHEQAHFYNTDPAASFEFFPRKEQTARPSAFLERSLPANLFPRVFMVANNQTIIYDVEADTETILPDIPNGVSVTAPTDGSAILLPLSPPDYTPEVLVCGGSVIDQTLQPGNFSSQHPASSQCARMTITPEGIAKGWEVDYMLEARTLLELLHLPNGQILVTNGASTGFSGWNAVQDTVGNSNADHAALVPSLYTPAAALGQRFSNAGMPSSGIPRMYHATASLTVQGNFFIGGSNPNNGSNFTTGFEFPTELRIQTLDPPFMFVPRPRILSMPEKLAFGTRVSVPISIPNSLNRRDANVQVSLMDLGFSTHGFHVGARLVFMDATTSNNGKTLSFVTPPNGRVYPPGPATIFLTIDDVTSEGAMVMMGSGNSPPTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RME0</accession>
    <name>A0A2G8RME0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RME0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RME0"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="65"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="236"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="671" mass="73303" checksum="EA6EA7873BC872D9" modified="2018-01-31" version="1">MPPNPLTLKQRLAALSANINSPSRSNSFDIQPESPITSKRKSFFKQPFGKSPSIPPEVPSGQHYGQERIQEVMNRLIFQAGVDYETRPMIVMCASAMPDPREVSYDLLLVRILSYLDLYVESDYTVVFLAAGNRHSPGWNWVWKAYRSLSRKYRKNLKRLYVVHSNFFTKMLFSLAGAIISPKFFRKITYINTLSELAYHVPLTQIDIPPAVYQENLKHERQINLPVLTRSDLFGVPLEELMGFDGEKGGLPRVVRDCIQYLRSTGLRDEGLFRRSPNSVLLKQAAQAYDRGHVVSLETFGDPHLAAVLLKKYLHDLPEPVFPERLYPIIRKCPIPTDDPNDMSAILYIRETLLAELPPCVYILLSNVLHLLHEVQLRSASNRMDAHNLTVVISPNLVSSSNPMRDVMMCSVPNAPTLFDAARAASTTNLAAAAQTASLSTAPAPPEGKATLGMIVKLCIQRYYEVFDEVLDRSEATSPTAVHGEEQEVFRPPHDPFDEMNSPTSSSLNNRDSALLEDDDIDDAMLVMPLGPPSRFSAGGSSGSRSAGSSAFRPQHRSTRSKDVAARSTHTTFGNGGGPPSAYATVNKARSTISIERGNPSRKGSISVGRGGSGTVRGKSAGSGVQAISITAEGFFSAPDAPPMPPLPSQLQNGNGNASANGNGNGNGAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMI2</accession>
    <name>A0A2G8RMI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMI2"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553553" evidence="1">
        <location>
            <begin position="27"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="258" mass="28804" checksum="3CB0395536A730BA" modified="2018-01-31" version="1">MLLALVQARSLLVLGVVSLFFSQILALSVPTPRHIDGQTPFLPPQGERKHRSGVLPPLRNTVGWVDPRLNGGQFLDYTTDTLGEPLNIIISSESDPDILTESGMQTYIKSIGFSRECLGLHYGHIHDADLGDGLGRKPEQFLGRQHYFPIIGTCWESIRGGHHFRAWRQNGTEANSGAWFLGASQEMDSSKNHMIVDDGYNRGRNYIVERATAGSHWRGMWWKAEVEWRDGLLESGNQGVNHGIEQDGLVAILTVHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMN2</accession>
    <name>A0A2G8RMN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMN2"/>
    <dbReference type="OrthoDB" id="3224585at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="126" mass="14533" checksum="5F984AC531A245C6" modified="2018-01-31" version="1">MSHISRHDRHDEMNRTDEALTFKKPYQIVNRPAVTEHDMHEQYLKHPPHPQILISGTFRMQNESSETATNLHSWDSPVEERARKAREAESLREDILGSPGRGKPLKETIMEEMATEDSVHPQNPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMW6</accession>
    <name>A0A2G8RMW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMW6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMW6"/>
    <dbReference type="OrthoDB" id="2368680at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="326" mass="36267" checksum="E5E8D61718C13DF5" modified="2018-01-31" version="1">MWPYLRLREAEVARRRRLYEASFVSRFLHTLGLPNPIATRIWASPDNSKQLSVAVRFALTRAWFELSVGSPRDSRTNPDSWLHGTVVDVQEIVPAEVWSVTVEYAASGARPYRRETLYVLETTCEVIGRPAAGVADSPGNLGGTTGYPRPLRVDWSAYITHRMATSETDGGLLAHLKWACQEDYVRGISTLWLKRIATEGQAGAAKRTVAERYVLASVIGNSISGRWMTTNEMAQEFAGLPARVNGQRGKKNATLNLFLPEHHHIESVHFTATGGRDLHPALAVVQTPHREYYVLRDNGMQVGCEEDGVAEVWQEVLRCDARGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNM4</accession>
    <name>A0A2G8RNM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2752093at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1352" mass="144400" checksum="3DD4BD151EC5E925" modified="2018-01-31" version="1">MFIQVSLSVLNINTRIVRGVVPRELVHSHLTRPRTSARRTMLRLPYYLPPYRLEHYPEGRKGPFVASPSLAAHLGMHPVFPSRSEYLYWVFEDRAFYRRSRARELDPQRSQPAPSSDSSGDDEYDDAARFRSRVWSGVDPAEVDSESATPQFLVNVRRARPKPPPTWPGVRRCLRTEEETAEAVARIVFGESGSAVTCDLPAASGVAPPVAQDAPAVAQDAPTAAQGLPAVAQDAPPVVQDASIIVQNVVTGNVSENHLRAPVIEPPHHPGPVFTSLSAFAPAASSQVVQNVSFQPPVPTLLQFLAASQQHVAMDGHLRAQVVEPFHHPGPMFTSFSAFVPAAPSQVEQNVPMNPQVHVETQNPVASSSTVPVPVSVPSPLPQADAAPVPPSPPTSPELLDTDPLFGGEDSDDEDDCVIIITPATPERPPTASPSQDVTLVEHQPMEWWPPAEQPQPQPQLEMAMEMDPVPAAPTPLVAHYQPMGPLQAPPTQGVEMAPSNVEVSMPIRDVEMASSDSGVQHTGLPQVRSVVRSVQPLRVPSVVQPLRVPSVVQPLRIRSVAQPLPVVQPLPVVQPLRIRSAVRPLSVPVPAPVPVPALVPTTIPVHEVITEAEHPQTGVDPSTTEDDAPVIRVRLSPPRRACRTANVVEAKAKAEYSGPSRPHSDDKGNDGDEGHSGDDDENSELMSELFAMCRDPNEWYIQPAVRVVDPLPRQACRAASVVEVKDKVAYREPNLSCSDSDSGDEDDSDDDEFSEFMDELLALYREPNLPYSDSDSGDKGNDSGEGHSSYDEDSRDEIEELICELLEMCRDPNEGRTQPATPARGSLAAVKVATSALSDLARSWPEESLVSDEDSDEDRDEGSDEGSSYGLSGSYETIATSEDPEVCSLADSFVKLNIGSTEAPPWVIVSPDAVPLVTAEETEVSVSTPVLASNATAKGLSLYKRIIRNVQSEEEVHSPQTSQRTALLLRPSTGASSFQLDGEAKGKLPQLELPHPRLASGPSTEHGNVGPPKKQEAIKTHELRRSLPPCDFKNVNAQATANAPVSSRPAPTISLSPSRFGYPNAMSRRPHSDKTSTTANAVQGSGAPSSSLRPVARDLGGAGTAYQGTSTLPVVKPLNIRKRNGQTSFPAGEARTVHQGTTTTTLPVVRPLNIRKRNNGQTSSSAGDKNRPANTAGSGLATTSRSGSASATASTSRREGPVLARAAGPAPASSSARVSTGTTGNGNGYPVSGILKTGCSASQQRPSSASSIRKVRLLLPGDTRIHDLGLDAAPFAGVYTRPASSRPSLLPRRVARASAPITPTSKSSLPTPQPIRRLAPPPPRRPMFAPARPTLSSRAVSLVKRSLGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNY1</accession>
    <name>A0A2G8RNY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_14529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNY1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNY1"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL23220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="500" mass="54479" checksum="33B9B8BF17441BF1" modified="2018-01-31" version="1">MSTKPTDHEKLSADGVTVEYVAPALAVDPGAVLRKLDVRLVPLACLLYLLCFLDRANISNAKVAGMANDLHLTGVQFNLCVAITLIPHSMLQAPSNIMLKWIGPSRWLPLITFIWGAILVAMAFYITVLTMPISVSVMQGTRILGSGPGELRFPRFVMSPAHCYSEQAGILPGLTYYISAWYPKSAQAKRIGIMYSGVSLAGAFGGLLAYVIEQMDGIGGLAGWSWIFVIEGLLTVVLAVYPEHATFLTEEERTWLLGTLKHDSAAGSKHFKREFIFQALRDPKTYLFVTMYFLGAVPVVSFTTFLPTIINGLGYSSTSAQVLSIPPNATGCIFTLIITYLSDKKHLRGPFILVGCPVTIIGYVMLLATKTPTIRYAGSILVAAGLLPSVATLLAWAGGNFAGELKRAVVLGMVIGFGNFGGIIASFIYRQQDSPRYILGHGVCIGSVSLFFVTCAFAMATLYRLNQKKIAQCEREGITRDHVDRFAEMGDRSPLYRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP06</accession>
    <name>A0A2G8RP06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP06"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP06"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrotransposon gag" evidence="1">
        <location>
            <begin position="95"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="255" mass="28130" checksum="3DD6B3A29D1D441C" modified="2018-01-31" version="1">MSNAGTTPAPPQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLASGTQPWADFAAFETAFKAHFCAADDEEAAIAELVKLCKGQHKIGTVQDYTVKFNAIAARTSFSAEDKHERYRTGLPYKIKDSLATSGHDTSSITKIQAVALTMDQNLLVREEERPKQFGGGWRKKGEKAAATDAHVRYRRARPIWVHADACGIDIEQHSLRSRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP60</accession>
    <name>A0A2G8RP60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP60"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP60"/>
    <dbReference type="OrthoDB" id="3237202at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="3">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="258" mass="28758" checksum="1C084B84FD8AEFE9" modified="2018-01-31" version="1">MGKFRPVGAVNERSKKAGVHCVSLGANRQVPLSKTQSSSTPLNPREGNVAKFIFRYRPRGLLQAQGIIPLPAAERKPIRLDRKIKKRPSDEVDRLDDISSSRPSKRSRRTHDLEEEDVKPSILKIDMSLEEDVKPVLKTCSSDEEEEELVEADIVKVDPSDDEEEAELEALAELEELAEHAKEVKKAKEEVVEEKEEEEEEDLELLQSQIQVLQEKFAKAVKRKATGGSQTSSVKAEPGPASQLSGVVIDLTLDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPY5</accession>
    <name>A0A2G8RPY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPY5"/>
    <dbReference type="OrthoDB" id="3063971at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="74"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="604" mass="66828" checksum="0F73B91A0BF87338" modified="2018-01-31" version="1">MHLSPAERHLFRVEPTLEVIQAAEATIRTHEGYIEALEDRIGGLLAQVRDLRYDQAKHRAAIERSRGLITLARRLPDELLIKIFGHLVADGWTRAPVVISHVCSSWRRAAHAPTVWSHVYVNCDDANVYERTKFWLRMAEGADVHVTVTASWRIPHWQIKQLMGMLVERSAQWRSLKVETDSLRHAELIFQECTLPLPQLRTIVVKTNAADSADAGVSDLQILAEQFTSEHAPRLARVEYASAVVPAAPTFPTHIASLALEIHESPVHRPLSAASLMDALEPLTSLHTLSLTMPLLYDHTFVPSPVPERTITLPVLSTLVCYGPTDLNELLPHLHTPALRALHLRSLEDLGYRQQPIAPSLLSFLALPGSEDGAPPLEVLELHDIDLAPDAFAAVFGALSGSLRELRLHESSISDATVRLLQGPGGLCPRLARLDLRWCGMLQGRALVDLVRSRASADADAEGSGSPARIEEVSVVNCAFVREEDVLDLARMTVCRIVMRDGDDYCRVRGLQSHALYWPLHISKPAGRCQANGNITVVASILYTLSRAARPSKRVRTDDGLNAKLEPSLDDDLTSDEEFWLEDGNVVLVAGNRAFKIYRGLLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQS6</accession>
    <name>A0A2G8RQS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQS6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQS6"/>
    <dbReference type="OrthoDB" id="73614at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF6">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL23857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="193" mass="21245" checksum="3D826AB7F6943B4F" modified="2018-01-31" version="1">MSSSSSSKGWFNLEAAGGVIPDTQFFEGDSAFSFLGLTRTQRLYGFIGWYASRMFQMKPTLEGSRELMNVAVDSLGLGFVLSLLGSIFLFLGSLTSFAFLYAIGTIIALIGTGFLIGFTKQLKMVGNLMFKPVRVVATILFLASIGLIFVGAFVIRSDLLCIIFVIIEYLAYTWYTLSYIPYARSAVLKVFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR40</accession>
    <name>A0A2G8RR40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13723</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RR40"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1856"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="4">
        <location>
            <begin position="232"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="763"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1003"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1532"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1133"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1168"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1593"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1650"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1674"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1725"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1762"/>
            <end position="1778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1918" mass="211075" checksum="6BA3060AB74DF976" modified="2018-01-31" version="1">MAMERKRMELALSGSSEPLLIRAAAAPDRAQTVPPLPPTPEFLNQKNSASANTRIRDIPISGPSSVSLDEPANIVFKESPSAKPSPSPPFIFPPPSRPSEGSMVAPASPRISCEGWVISELCRKYPNFHEVRRVKASTVSEDLSRIMEEYETVGNPLIVEGWHEHPGWRQDLLNLDWLLAEVGDKEMHVRNVHNRRDFSLNLPTFVEMCRKQALFHEPGEAYRCYWKDAECPLQWKEWLGTILPPELLPGCSGDLLRHLYPSEAVESLMCYLGMGDTYTAAHKDICSSSGHNLMCFSENGGSAFWFMTESKDASKAAEYFQKVLGQELDWEIHVTTLEELGNAPFDVYVAEQKVGDLVLVPPRSVHQVVNHGGLAMKTSWSRMTLQGLKTALHSELPVYRRVCRPEQYRIKTVLYRTMLHHTESLQSSLTFQATVNDTNGSLVGTNTLDLEYTSDKSDSGYELPSTPSPPPTTEQRADTLRSLVGLFDEVLLEESGWSVTTETSMRRKVVLVPPSDPRDPMEKQQAGTCNFACDFCGADIFQSFFECRACAGLLGQSTQPGDGFLVCPACYVEGRSCECDEMEPVQCRPLDALITARNRAAEVLRQVAATSNIKAPLELHESDLNKHKDIRVFEAACAYRDLKRKRYADDDRQCRATKSDMHTSPASACLRCPVCKIYKCFPHFLRADTHVAEAVLAFSKDKDDLHTVHRDNNLRRKHSPLRLYNVRGSELKTRLTIAAKSFPRCKPWHTKMRVGFYDTEFALDSEPDEEPSPPPPTPSCSDSRGSPRHIPPQLNLSATSLQLLDEGETSPLTSLDSESPERPATAALCPEESHRIWDEPEELIVSVDKPDVLLDLFGDPVDSNQHRSPSVSPTATAVDATSEVEISEIVNQLDLPRMRKARQNKAYVEIPRQKLHKRTVSSSSSDLEWVDEPQPKKSRPTHQRAGEKEPRAVRGRSASRAEPQTTRPSASRKSKARGASEDDFVEASYGPDLACALSKAVAVETPVLSQPRGERPSGPLPRRSTAAKRIVPPHLDNGASPIRLEPSNPTTQPPPALISPRPSSSMNAPRPLPRVKQPALSTSNKLAPPRPSKLPAAPANADVDMSRPPKRKRGNPPGIPHDQMDANMASRRREPRSRSPRKKARVAQRPDPEVIVIEDEPVPMTVSRCRSPTPASRMTGLNSSSSRPLLLLPPPQLSKPRNPTPPTNVAGPSHVGNSGRRAPSVEHQAGPHPSDDAPPPVLNLAAPSVPPLVSKFAPEPAAGSASASSSASAPVLVSTQAYPPLALAVQPGTTHANLAQRLAALNNNYAPLPESNPAPSNATSLQPVESNDLKAMSSVLGLAATAFASAATMNEKCQQVMQTYDSVRQRLDDLEVRTPSVAQRQPSVDDMAQLLARMERMEEALEISEDQDKKLARREEEVRQLRDQLQREHSESEKKIAQMYEEARQGRQERHHMAVRVRQLEGEVETLKASLADCVKKEALPEAVGAAVSSSMLPLRTSVEDMVVRAVEKQGALLATTSLPAVAEQRPADLPPHLSQDGPAGDIRLQLDGSRQAPQPHPGQPPWHGAPNVMYGPPPRHGNMSCQPPRAQIGQQFGGNHQYNHDQRRGGYQRGGFRNGGHSNYSTHRHPNDRHQDPYNNWHGPNRPEWPGRPETRQWDRGPYAGEAPIRNGHQHEEPVREPVRDQPRRDSPARGRSVDVRSEHSSASSHREHSCSAARSYSRSTERDQTSSIHQLDDTPRDVDKPGPSTSNDTIEDHTSENSQQSRSDIQESSSTQKVAEAAIQSATQPAYLAMSHGVALALVLFRVAVPRRAIVLGLSTGPRLRAGPDAALQCRAGPVIVLHASLHLVMVLNFLSPITIASLGLVTTLAILSPATRHHRPTVTMGLPVEDPTFTSEADLSASSASLSYYLLIFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR41</accession>
    <name>A0A2G8RR41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR41"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR41"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="149"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="49109" checksum="4E50FD528074BA8F" modified="2018-01-31" version="1">MARFDASLTRYASEWHSSDQAPFLSLRSSSTSLHLDRPDLGLSPFSRAHHLQLPNSYPVCTLVPVSMTLSSIAKHSLARTSTRTTSKCSLHPKHARYFSPSAPASSSSLPRPYRFHVGASWAGKPHDPRGPRVKSNPFPPDSPVGRWRDATLARPNAAAGKHIGEDFFYIQDGISLGVADGVGGWTESGIDPSLFSQALMFHAHRYSKVAWPGEPEVDPMQEYEEREQVEGWELSPVECLESAYGGVLRERNVLAGSSTACILTLNASTGVLRAANLGDSGFLIIRGSQVIYQQRAQTHFFNCPKQLSKLPTAQKRFSRAVVDHPSDADLCEIKLRHGDLILAYTDGLSDNVFPSEMVAICSLVARQFQFSRRTLTPSGETEIEGNVEDQEVQAMAERIVDYARICMANTKRVSPFERAAAREGMYFRGGKVDDVTVIVAMVQEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRG1</accession>
    <name>A0A2G8RRG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRG1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRG1"/>
    <dbReference type="OrthoDB" id="3058872at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="773" mass="81839" checksum="1BFCDA2BD80FF768" modified="2018-01-31" version="1">MPDVVVRPPSTRPPSAAPAPSDLYSRARSSSAAAGSSAAYTQPQPQTLGEADAYRSGGAHAKGSPSQDLPSRFPVYEDTTSANRLAASGAPHVPSASPKRGLTYPGASAPAHPSSVHVNPSNYQGSGTYDPRSPKPPSVQTITNDPSRLQTYLSGSPAGVPRTVSAGSSTPKHSPSVRLQSHRNGSNDTITHAAPTKSSPSGSSQQHLPHRPSAVNMQPQLHASSRLDAGTASRQPNASSAYPDINRYRSPAPQTQGYPNAYASSSAPINSPSYSTQTPLTNVDYQQYGRSAATPTQGTFATQQVQAPSAQTHARSRQSVDYGLRPEQILVTNPLASPAPTPQRIPPRAAPSPAPTGRPPRLLSSLSSKVTAPLHSAPPTPARNQTFPNPGSSYTTTAQFPTAHSRTVSDPQYADRVGTGYVSASLPTRGRAASQQQQQDILLTPSSLAPSMLPQTSVPLIPLDRSISRNTVNGKEKEKEKKRSFFGSLFRSRSSPPKQRDEPPPPPSQQIREKRERNNSQPTQPVAYMQAPTMANGASRPSRVPPPSPRTAVAPPALMPAPASAPTPGPAHQRGYSTSVVPNNAPIAQPAPVSLTRNTSGKMFTPFRLLSKRHRTVSTASVDAVDGTVLTAMLTGGDSTRSSTAGRPSPPLRDPMMAAQEWRNQEEVVQQGRGTLRRRRPGVTFDVGEEVPEDGRPSLQKTLRANLAAMAAAQGQVPGAQAQDHQQQQQQQPQAVQTHQGYQAQAAQHQAQGYPGQASYSHGQLLPTRQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSL8</accession>
    <name>A0A2G8RSL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSL8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSL8"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="271" mass="29888" checksum="696A988C0C91704E" modified="2018-01-31" version="1">MMPPRAYIFFGLNAVRILSIISMILVFASSIFVLVNDVQAVNRAMASHDDMSNCDYIEGSTVPNQPAGVFWAVVNRLLIIFQIIVLILSEIGWPAAFFTTYFPVLGPDFGLGALGIFQCLIGATILSHHVDDFTLVAAFFLFSLGCLNMFLGLFRERTKHRRSIRAWREEAKGVLPTHKDLRPPFARPASAFIGRVFNRGGEKAEPMPVFESKGLGFGRQGEKAAGMKGFLISKPLESLPRYATQPPRSDSRESSRAGTPEPKFKSSATAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSR3</accession>
    <name>A0A2G8RSR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000057">
        <property type="protein sequence ID" value="PIL24549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSR3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSR3"/>
    <dbReference type="OrthoDB" id="2796844at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF455">
        <property type="entry name" value="RLK (RECEPTOR-LIKE PROTEIN KINASE) 8, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013876648" description="Reverse transcriptase Ty1/copia-type domain-containing protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="106"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="367" mass="41225" checksum="D80DBBA9E677BBDE" modified="2018-01-31" version="1">MDLGRCRELVGAISIFVLILLVVEQASKANQEHFGEPRSMSEVMALEPEERNKWLKAAQDELQSLVENGTFELVLLPSGHKAIGFRWVFWVKRNADGSIECYKCCLTSIRAILALAALKDLELESVDISSAYLNGELKEEVYMCQPDGFEEKTPQWVWRLCKALYGLKQAGRCWHEKLDKVLNQLGFEQLTCKHSVWVYLCDGVRLIIPVFVDDITIAGKDKAVIQRVKDNLRKHFKLQDLGPTSWLLGVQIKHDHSKCSLSISQRQYALDIVKRYGFSNYDPVSTHMDPGACLKPHTFLPAPCYIKGTLDYKLTYAPSPEPELFTSFTDADHAGCPNTGRSTSGYVIKMGTGAISWSSCLQALVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTK8</accession>
    <name>A0A2G8RTK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTK8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTK8"/>
    <dbReference type="OrthoDB" id="3270344at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="658" mass="72316" checksum="5C7E18D46091B54D" modified="2018-01-31" version="1">MDTIQEHVPIRIPDACFWADFNFAPGNPIFISPRLDSTSIPLSPRASPAPPHTPDALPPARASPAHRHAMEVETKPNASIASLMASAARSASIPQKRKEPPPHSPTRPREPERANSQSETDAGTQATTPTTPTDEYGSGRVLCESCGEGISIKDDAGGFTVKHWEAHRNSCQNGSASTVDQLAAESPTTTVEVSHHHQPQAKRRRAKRTEEERIEYLRSDPYVAKFEAYRVLCASCDKWIRLRPNSTYCSIPWDAHRKSCLAKRVAKNTHLVDDRSAAFSADPNVKRFDSSRVQCRTCEKWIPILTDDNAAAIKTWKQHRDTCQPQSASSSGASTSKFNIANVPPPPKHLLALASSSSLPPPSASARTAVAQSLSHSGKAANASPTAAGAFTTAFKDYTPNNYAGTQESRRRNADQRAAALRADALLGEVEPNRVFCKMCQKWVQLRQDSTYCAYPWLQHRAKCLMKHQKISDREAEIAELRATRDAALVDELEVTDSSAHSGTEEGDDGGDSADRARQKAERRRAKAQAEADAAAARLRQLEEAPRPGRAGSVASSEDDDAMWDYMDIDMVLPPRLAELDSPAGRLDFASRSIRHLFRITYARSDELTIAALVTYLNAAMPPDKHEDFDTAEVTKMMTALHERGTFVFEGDVIRIPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU96</accession>
    <name>A0A2G8RU96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Phosphomannomutase</fullName>
            <ecNumber evidence="5 12">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_12981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 12"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU96"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU96"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL25092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="223" mass="25338" checksum="E04BC54B9F824341" modified="2018-01-31" version="1">MTALLRTLRKKVAIGVVSGSDFVKISEQLSPPGSKVIDEFDFTFGENGLTAYKLGQQLPSQSFIKFIGEDRYKTLASFILHYIADLDIPIKRGTFIEFRNGMINVSPMGRNATNQERKDFEVYDSQHRIRAAFVEVLREKFSDYGLTFSIGGKISFDVFPNGWDKTFCLQHVADEQFEEIHFFGDSTHKGGNDHEIYADPRTVGHSVKNPADTMQHLKELFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUD9</accession>
    <name>A0A2G8RUD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUD9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUD9"/>
    <dbReference type="OrthoDB" id="74201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10208">
        <property type="entry name" value="ASKHA_NBD_ScArp9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="494" mass="54039" checksum="82EB74F30CE53A09" modified="2018-01-31" version="1">MSSNNFRDSTVVIIETGRTTVRAGQGLHDLLRLPTVDIPARVGLRRSLVSPNGEIYPSTSTATPAVKVTDYLVGSQLDEALATGQDIVVSWPFEEADISDYTQAEALWKYVLFSQLKLRRAQMESPVMLSIAPGLSRDAYERVCQIFFERFNVAGFAILDRPMAQFYSAISGLQLSGVVVDVDQDYTDVAPIYDGFVVHTARTQVPLGLSDCLAYLAHLLRSNTSVMAALSPPDNPPPPEALQESLLELARHVWQSGLVKVLTEGEAARDLEDEGVTDIAAIVVAGKERAVIESGMKRRQNAKAQPAEQARAKEIEALDLVTTEFRGLELTLGKERHRFCEPLFDPILLDGIPGVREKGHKDRRRSVQSVIGDAVGQTDIDQRAYIWQGLFATGEITNHIKGLGTALSGRLAPYILSAPDVQNNEVQPRTIRTLRVPDYFAEYRDKGDGLAGFLGTSIIAKLAFNDSAGKNYVSKADYASKGPRIVLGMSPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUS5</accession>
    <name>A0A2G8RUS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUS5"/>
    <dbReference type="OrthoDB" id="2765866at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="600" mass="64598" checksum="3FD90F420AF8ECD4" modified="2018-01-31" version="1">MTGTTTQEAGQFAGNTPFLGHNIQGHSVGVKLVREVPAEVLRTSVTHFGTRGLFGKPILRTSQHDHDNLRRKKWRIAQSLKSNTRKAKPNLKGRGHHGAPGDNAGVPPPNSNFPGPVNATARRRPPTPTPLPPLPPLPPLPPPPPLPSPLPNIVDPSSLPTHVAQTRSQIRSVLSYEEASCTATLPASASGGTLPTFADHHNYVLSPANHFGNAPASLHPSSRYAAPASEGDMYLDTGYCLPVLTSNKHSAIQAPFTIEPVNSRYGIDASMSEPPLILQASSRAHIAPWTDKTPKVPHNELAVDANVNIRIAELNCTQGGMLDEKPLYWPPSSRLGAALSECPISMSVGRKGESSQVYPSIPGGLHATGESHSTWYGYPASYTASISPCSPIAPSPPQDVSPGRKCMPFVDRCSTPMWISPMHEREDWGINLPPNACDTYSASPSLAPVFNQYPGNDASRPVLTSPSDEFISDLTDRYTRGSETRYTSLPNEPIGSYGLISTPMSAPQDVWQILPELRLARAVDTNVNINANTSCPYPQPIASETDYMQAFDGNPSTDHPSWLSLIPRMSHSLAGSRRTQRDSGAPSSHFRTSPYTPSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUZ5</accession>
    <name>A0A2G8RUZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUZ5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="199" mass="22476" checksum="EB368D935A3965B3" modified="2018-01-31" version="1">MEDKRREVPEDTELVMVAQDSIGRPWASKIFFTRFPEEVPETSSSVLEISFHIPVIDFTTLPDSNVVRYHMRRRAPTFVLLLLISTIRHPALPEVPTLIRGTFPSEATPFDPATNGKELRHISRKKALLATTQDGERKDLTKHWQAIREGSEVATGDQRSRDQIRTKMGRRGRGGRGKRGWAGCRSRNGRIVIHSGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV67</accession>
    <name>A0A2G8RV67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV67"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="69" mass="7705" checksum="E06D54C96750B7E7" modified="2018-01-31" version="1">MAARGQLWNEILELGQGFEVRALRAPSIRIIADSDLQRTCEAEERTHGQPGPRRAPHEDIVQVSNSAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVV8</accession>
    <name>A0A2G8RVV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVV8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVV8"/>
    <dbReference type="OrthoDB" id="2754813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="4">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="176"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="37795" checksum="67FF233FA4636E59" modified="2018-01-31" version="1">MQPAVNTHTPHTGSVTSLAFSPDSQWVASGSDDTMIILWEAETQSVVRIWESHDDIVWHLAFSPDNLRLASSGGEGRIMVWDVDTGEQLAILEGHADTIHTVVWSPDGTKLASGSDDMEVRIWDTQTYEQLHLLEGHDAMVTFVLFSHNGLYLASGGADYNTRIWDVATGALHKELKGHRGVVWTGSFDEEDNRIATASDDGSVRIWKVETGEELVMLHEHHGPVWVVSFSPGDGRQILSGSSDSTLKICDFFTKEVVETLKGHDSMINSATFSPDGRFIASASSDNTVRLWRRSDGTNMKTFNEHNDKVTHALFSPDGTMLASGSDDTTVRIRVLSDIVNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW17</accession>
    <name>A0A2G8RW17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW17"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW17"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045:SF34">
        <property type="entry name" value="ISOFLAVONE 7-O-GLUCOSYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 72B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="59854" checksum="83006C01A9476670" modified="2018-01-31" version="1">MAYSRNHVVLFSYQAWGRVRPLVNLAARLVKLCFIEATILVSNSLFERVQAELARSFEPGQDDLMEHVRVISYGDVQGPSIRSDEGDALFEDSWKSIVFEQDSVCAYTGIRYPPLNQPKAIILDLFAVDLFHAIKAITGDAVKVFAWEPSLVSSIFHLFGPEKLGGKGNVRMVAEGEVHRTGRPYRDVVTEMYFHPAGDVVRAPAMPPMYDYEYWPQDFPMPDDAWTKIFPRVYETLEAVDGILLATPDSYEHEAVAVMKEWFMETSRPAYVCGPLLPSASKLVAEMYEMEESDSSEEVKWFLDAALARFGPHSLLYISFGSLFWPVTNPDTLWAVLDVVMERDIPFILSHGSSRAVIPDYVKAKVKAYGRGLLTAWTPQQLILDHQATGAFLNHGGHNSVMEAICAGVPQIVWPFGSDQALNAVIVSEKLQIGYELVEVRSGANGLKPICRSGRVPAGTLAAVKAEVRDLLEKMFRKDDGDGEKMDTKMRARVAQVRKAVLGEWEEGGASRCDVVAFLDTLPLGLPCLDYSPGLACY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWJ4</accession>
    <name>A0A2G8RWJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein transport protein SFT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_11635</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWJ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWJ4"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL25882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="211" mass="23033" checksum="AF32AB449B81E391" modified="2018-01-31" version="1">MPAQSAEQSFRDNLSQFRWARGNNDDSQQQQQQNASTGSNPFSRFYNAIGNGYVPLRSNQTSNEEEAYFALSRWERLLGFGACLIGAAVCFFVAFLTLPLIALRPAKFALAFSLGSLLVMFGFSVLIGPINHIKHLVSKERLPFSIAYLTSLGLTLYFSLGAHSYLGSLIGAIIQVIALVSYVLAYFPGGTQTLRFGGQMALRGAGSLLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWV9</accession>
    <name>A0A2G8RWV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWV9"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013795676" description="Transporter" evidence="2">
        <location>
            <begin position="26"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35159" checksum="4C0F7C12018204AE" modified="2018-01-31" version="1">MSSSSKIPPLDKIFLIGLWIGVVLEVQSQQQSCASCHLAPVVQVCVTIHVSTSLRQGLEAFIYTPPGAGPDYASLYFAQEGATLAATKNGLYTTAVFIQDLLLIWRMYIVWTRNWKIIVIPLGVELFHMGCAYAAVVILTQPDQSIYTAKITTLGSLGWPLELVVNARVTGAIASRLWYMGRVVSRAAGTGSTGISKNNAYTGPILTIIESWAILIALTFVMLVLYKAGNPAALMCTDIATQISALVPYLIIVRVGLGLTHTLPNAYKSYKETNNLRSLGGSSGMRFAPNRLFGIGTKTSQSGPPQVAVTISETITSTANDENIVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWX7</accession>
    <name>A0A2G8RWX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWX7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573924" evidence="1">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="112" mass="12474" checksum="E86EC3D25B33D14A" modified="2018-01-31" version="1">MVMLWLCPWLWLRLWFGTEQARAVEVSGVRRDAFGRMMPRPRGNFGRYCPGQPGAGIPVEKLNILAPGLGWGQGGRMLSTTLIGDRLYPALLSSMGRDLAVAPDSMLLKMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX94</accession>
    <name>A0A2G8RX94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_11692</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX94"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX94"/>
    <dbReference type="OrthoDB" id="3205891at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="141"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="700"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="994"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL25938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1060" mass="121979" checksum="158DCF7A6E30C212" modified="2018-01-31" version="1">MVGRICVAVMVEEEEEDKPPPPGFLPEWDGTEESLLDALATGQTLCNAPKLFVSATYTYSQQLAEQEYQKKEIRPVEEIVPKQYHEYLRVFSKEASERLPDHGPYDYAIELVPDARMFHSKVYPLSPSEQVELDKFINENLAKGYIQESKSPMSSPFFFVKKKDGSLRPVQDYRQLNDITIKNRYPLPLVSDLMDRLKKAKYFTKLDIRWGYNNVRIKTSDEWKAAFVTNRGLFEPNVMFFGLANSPSTFSALMNDIFKDLSILGKVTIYLDDILIFTNDIEEHRTLVCEVLKHLAECDLFCKPEKCEFEQPKVEYLGVLVSENRVEMDPVKVKGIAAWPVPQNASDVRKFRGFANFYRRFIKDFSAGCKPLDHLTGNAPWKWEAEEQEAFDELKHHFTESPVLSMYDPDCKTRIEVDASGYATGAVLSQEGEDGKWHPVAFHSDSMSDAERNYEIYDKEMLAIIRALQAWRHYLEGLPSVFEIQSDHKNLEYWKTAQNLTRRQARWALYLLRFEFVILHKPGTSNGRADALSRRPDHQTDDADDNLDRVLLQPDRFRVLAAKRGHMSVVPEKALLRRICECGEHEQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGRVYVPKDDALRAEIVRIHHDLPPAGHPGQAKTVELVTRNYWWPGMVKFIKDYVETCDTCRCGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNALQLIADWHGKIIHLIPCTEEIDAEGTADNFIREWFRLHGLPRKIISDRGPQFSSKLFRAVLKGLGIESAMSTAYHPQTDGQSEWRNQEIEAYLRMYCSRHRDDWVKWLPIAEFACNLHVHSATGYSPFYLMYGFEPQFHIPMLSTAVPSADERREELRQAREDATSALTLAAERMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHISLLLPHKESQLPGRHPPEPASIEVEGEEVLESRRYGRWKKLQYLVHWMGWGPEHDSWEDATDLANAPKVVQKFHSTHPDAPSPLNKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXC4</accession>
    <name>A0A2G8RXC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXC4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXC4"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="345" mass="38998" checksum="4D551298199FCD3B" modified="2018-01-31" version="1">MAPKMPYVRLGSSGLKVSKIILGCMSYGTPEWQDWVLPEEEAIKHIKFAYDHGIQTFDTANAYSNGLSEIVLGKAIKQLGLPRDELVIMTKLYFAVPKDQTNIWAVGVQAENLGILNQKGLNRKHIFDSVKASLERLQLDHIDVLQCHRFDYDTPIEETMQALHDVVKAGYVRYIGMSSCWAYQFAAMQNYAITHNLTPFISMQNHYSLLYREEEREMFPTLKQFNVGAIPWSPLGRGLLTRPLAIDTIRKKTDGFLRAYDIPFLPTLLERHVPVEELAKKKGVSMAQISTAWIMARPGVTAPIVGTTSLKNLEDIIGALDVKLTEDEMKYLEEPYKPLSVLGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXE3</accession>
    <name>A0A2G8RXE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXE3"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34803" checksum="1571D25939C5E8C6" modified="2018-01-31" version="1">MAVNFKSRTFRVPGIVFLFLSFILLFIVSISLPYLTDLDVVRVHFKDSLPTVGNDTNPITAVRFGTWAACWYQQNGDRVCNTNHGGYSTTLHDPQRMSSETIAASWTRGLAIHPIAAAVTLVALGLSFLTHASARLAAALVAFLAAFLTLLAFLAEIALYGWVKQRVDKLNGVGSETAIGPGFWITFVVLMLLSLSGCTVCVGRRRDRLDDAQKYPYSWKAGAPRRVPPAPAPFPAAGTRRVPPAFGSPAPGGRPTISAPMIPGMTAGEVEKEKEAEAEREREEMETEAEMRMVPPQLPPRSASTNRPVPPPPPPGLGAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZA5</accession>
    <name>A0A2G8RZA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZA5"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF17">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="471" mass="50968" checksum="71764E443E282A14" modified="2018-01-31" version="1">MVNYPAWYTTPMAQVVLVGITCFATVGMFSAVSNLGAGGLSDVALSDTANGVLYACFALTGLISGGITNLLGPRLTLFFGTLGYALYVGSLWCYQTQGTGWFIILAGALLGVSAALLWSAQGCIMMSYPLEKDKGKAFAVFWAIFQFGSFIGSLIALAINIRSGGLSAVSTSTYIAFLIIIFIGVASSFLILPPNKVIREDGTIVKLDAASKPHEEVVGLFRLFKDWRMLALAPMFFASNYFYAYQGAVNAAVFDGPTRALNATLEGAGAIVGALMIGYLVLDLKFLDRRTRGYFGLAVVAVLSIIVWAVALSWQVTFDRWDVSAANKNRIPFINYHDSNYKGKAALYFFYYFADACYQALAYWIMSALTNDPFTLARYAGLYKALQSAGAAGSFGMDAVATPFLNEHLASWLMILVSLPLAWIVVRTVKETNYEDEKMVYVDDAKREAAEHGAAGPESSSIEKQSVEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZG5</accession>
    <name>A0A2G8RZG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZG5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZG5"/>
    <dbReference type="OrthoDB" id="2755751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="306" mass="34243" checksum="214E0765FF393BA6" modified="2018-01-31" version="1">MILVDAFYNNDPTLSDPGKRVEIRNRSKGNFGGLLTDFDYAKILDPSDPSSSAGDGSPTVSAGFTILFHPQSHTSRTGSQGTPLFMASELLWSIYYRKPCPMHTVYHDLESFDWVALYAIYKHALGEVPTTHPLHRPLAREFARLFTAVSPKNVFERRIIAFSLDGIPSLIAYADSIAESESESGRLGAFLIGVWGELKATFEGHRDWQSRVDRERPSKKRRIHRPGREVVRYLSEKFRDFPAVAREVSDALATEAEAENSDDGTLDEAEEDEEGVEASSQLDPAFPVPCYKYEDQVLKVNVLIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S014</accession>
    <name>A0A2G8S014_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S014"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="62" mass="6579" checksum="577D2D174ACC7F6B" modified="2018-01-31" version="1">MHFVQQKKGFNTWQITACLSFFAIVSIPVLVFVKGVIEPDDVDASLSPSAGTGIQGNALVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S041</accession>
    <name>A0A2G8S041_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S041"/>
    <dbReference type="STRING" id="1077348.A0A2G8S041"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="86"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="585" mass="63501" checksum="37FEF29CA77516EE" modified="2018-01-31" version="1">MSGLSSPGSSTSTLQEPTRVHTLLQESLRRDEIRAEQYGGDDPQDPLPKQGDILPPSKEVYSLDPALVGWDGPNDPENPQNWSSRKKWATTILSVLMTVNVTFASSAPSGASTAIATEFGVNTEVGYLVTSIFLCGYVVGPLLWGPGSELFGRRIIFRIGLAVYVILHLGQALANNMTTLLVTRFLTGVFACAPLTIGGGVIVDIWDPITRGTATAIFSAGVFVGPVLGPIVGGFVIQSSLGWRWIFWIMMIFAGFCTVLAFLFLPETYAPVLLQWKAERLRKADPKANAQLYAEHERSDWSFTGVLHRTLYRPVQMLIREPILLLITIYISLVYGVLYAMFEAIPYIFITTRGFNSGEAGLVFVGVGVGTTIGAYLTIPLSKHYPKLIVKYRGFPPPEERLYGAMIGGVMLVIGAFWLGWTGEYARIHWIVPALATVPIGAAVALVFNGFLAYLVDTYLQYAASAFSANTIVRSCVGAAFPLFTVQMFSALGISWACTLVGLCGLLLAPSPFLFYKYGPRIRAKSKFSPCPDLAIAKAIAEEEAAAAAKGEAQAKRVPPLLVSVWFPGTTLPAFDDDHRLASCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0W6</accession>
    <name>A0A2G8S0W6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0W6"/>
    <dbReference type="OrthoDB" id="2749434at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="271" mass="30839" checksum="4C657AF502BF14A6" modified="2018-01-31" version="1">MPRSPTDPPALNMSPELPFAPEDGQTYYLEDKHAVFAQQPLQGPSLPECLMPSRSSTLKPPTLMYGWRLGHNKLMQIAVDHFPQVVRYRKGPALLGVVDEETYPWTDEDWDNEHANVAETILDYDFIVAIREYLGFGPEAKDLFDIDILYDSRRQAKYGLTVGSNYLKVIDNDAIKKLEALLATDEPAMWYLHSKKWMWRRVVRKAKSKSKWLPPFVNELEPETVVAKSKSTKSKSTKSKSKSTQSKAQRHEGDGKAVVAFNEPEVMQPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S105</accession>
    <name>A0A2G8S105_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10602</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S105"/>
    <dbReference type="STRING" id="1077348.A0A2G8S105"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="126" mass="13364" checksum="580F5167040C81BF" modified="2018-01-31" version="1">MSWQQYVDSNLIGTGKVSKAAIIGLQGGIWASSPGYTLSAEEQKAAVRAFEKPDEVLASGVRLGGQKFFAIQANPRSVYTKKQGDGAVLVKTKQAVLVAEYVAPIQAPETTSIVEGLADYLISVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S163</accession>
    <name>A0A2G8S163_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S163"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="124" mass="13723" checksum="B869ADFEF076F7D2" modified="2018-01-31" version="1">MNAREPSPYSVGMLISKIPKREYGWSSTLVVSRLEAQDIRRATLTSSSRFCCFNTSTSIPAISSKKAGRSCLEPMTFHSCDMNRRFRGAIGSWSVQPLVNHLLRRNLDFAPCGRSSCGTSTTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1B6</accession>
    <name>A0A2G8S1B6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1B6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1B6"/>
    <dbReference type="OrthoDB" id="2802742at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="297" mass="31967" checksum="72080DC68B9ACE97" modified="2018-01-31" version="1">MNAKLAATPAISIMEAPSAPATARPSLSVRCPTFPLEKAALTELAMTIAEEIATLSLSHSPMGIDVPLQHTGLNTHSLALLQSWLKSAYDYDVRMSRLMEDDTTAEALAADILASPRTRKARTLPVPIKQVGSGSFASRRSRKPPRAPISVDVTTGPDEIPITSAATRQYVADIGMVPFDSWSNRKSGLMYGLLAMGLVGTPLTPTPSPNTHSVKSPAVPASFSSSMRLRPIAPLDDPRAVMPMRTPIFTSFLDSVRMPGVDYVQSPWTPDHHYGSMNGMFAELRFPQTPLPMGTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1Y6</accession>
    <name>A0A2G8S1Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1Y6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1Y6"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="279"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="480" mass="51380" checksum="01C432A629ACB0E4" modified="2018-01-31" version="1">MDIQVAGESLAIETLEMSAMPSSKDSQPESPTKALSAQSSMVALRAADPQEGTTVQELPPVDRGSGAWTFCASAFVVEMMMWGFSFSYGIFQEYYTSHPPFNTASPVSIAAVGTVMLALLYGESFFLFPLLGRYPDFLRVSMWAGLATYFVSLFASSFATQVWHLIILQGAGVGIGGGIVYLPIIKLLPEWFSERRGLASGIVFSGTALGGFVFPLLLNALLNNLGLRWTLRIWAMGTTVASGIAFLGMRSRLPVPRYNAVHRRPKLLPGKLDFLGTTLFWSVAITNMLQGLSYFPVSLYLTTFTKGLSNQLTATIVLSLFNVSAVIGQIIIGHLSDMMPYPSIMLFSAIGSSLGAFLLWGFADKAIYLYFFAIIFGSLSGGFSSTWTNSAVECVGGKPELIGSVWTGISFLKGISAVIGPIISGFLLQAGQGTTMAHGFGKFGYGAVELFVGSCALGCGVGSVVIALARKQRVEVLPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S206</accession>
    <name>A0A2G8S206_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spermatogenesis-associated protein 20-like TRX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S206"/>
    <dbReference type="STRING" id="1077348.A0A2G8S206"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="15"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="720" mass="80653" checksum="51CA463790F59774" modified="2018-01-31" version="1">MSTSHGKAREEGGRTNRLAQAKSPYLLQHAENPVDWYEWGQEAFDKAKAEKKPIFLSVGYSACHWCHVLAHESFEDELTANMMNEYYVNVKVDREERPDVDRLYMTFLQATTGGGGWPMSIWLTPDLHPFFAGTYFPPGNFRQVLMKLAEIWEKDPERCMASGKQIIAVLRESSNIAPEGHVNANLLTTAVFEHLQKRFDSKEGGFGSAPKFPSPSQTLYPLARFAAYHLSNPGAEAQDKNAAEVARDMAVLTLTKIYNGGIRDVVGGGFARYSVDERWHVPHFEKMLYDQAQLLTSALELYQLLPSTSRSRTTLELMAKDIVSYVARDLRSPEGGFYSAEDADSLPTRDSTVKKEGAFYVWTAKQLDELLGADAEMFKYHFGNVLFTAHTTEETGKKFDKAPEEAQAILDKALATLREHREKHRPRPHLDDKILTCWNGLMISGLSKTYEVLHSDKIANEALKLAEEAAAFIRAHLYDQASGTLSRSYRDGQGPTGQADDYAFFIQGLLDLYEANGKEEYLLWAIRLQQKQDELFHDHVSGGYFASAPDEHILVRMKDAQDGAEPSAASVTLSNLQRLAHFAEDQHTAFNDKARSILASNGQLLKQAPHAMGTMVGNALMGERGYKQFIYEGNSQDSESPLLSLIRSTFIPNRVLLHFNPSNPPFGIANVNGSVRSLVEEVQKRKDVKENVRICENFTCGLPIEDAEELKKRLPLLSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S248</accession>
    <name>A0A2G8S248_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome recycling factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_10790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S248"/>
    <dbReference type="STRING" id="1077348.A0A2G8S248"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="112"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="268" mass="29413" checksum="0A1A944930090A8C" modified="2018-01-31" version="1">MSAAALISRTRLFTTSASFLLHAQCRSRATRPVTLAMHQVRSYAKPVKKSKDKGKEKESADVPQSGKKTGKGLSTDELIPASQRIPASADYKAAETKMQGVLEWFRKEVAALETRATGRVTPAVLAPVRVKLPNASDARGVRLEEVATVGVKEGTTLLVTVFEEHSLKYVEQAIYDAKLPSITPQKLDNRTVKIPIPKPTVETRNALYTAASRQAEDVRVQLRKLHQALLKKADVSKHSADFSTYQALSDKLMGELDKILAHLKKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S268</accession>
    <name>A0A2G8S268_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000033">
        <property type="protein sequence ID" value="PIL27873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S268"/>
    <dbReference type="OrthoDB" id="2756029at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="284" mass="32037" checksum="8D6E86F734D384ED" modified="2018-01-31" version="1">MGVLDGLSLPPRTLVRLDNLYIPFNSEYPAPIPRSLNELLGGITTMQLAVDKEMLFLVVEGESPESGLWLRVRHEANTFWSHWLSGLHVIMVPLGNLTSLHIDLYDPFVLTVLSQLSDLFVLLEPDKVAEERVRINALVPRVATFCSVLSQSQPMACPSLRSLVLEWRRDTLTYLEDLGVPDIFAMLSSRASFGHPIRRLVIQAIPASGAESGSTLQSHFSEQLSPLAGHVEEFEECVDGDAHVCAFKMQEMWNVTGAEDYWCVNERQRPRYIPLWSYDYSFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S289</accession>
    <name>A0A2G8S289_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7223 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000033">
        <property type="protein sequence ID" value="PIL27872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S289"/>
    <dbReference type="STRING" id="1077348.A0A2G8S289"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013815943" description="DUF7223 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="3">
        <location>
            <begin position="281"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="573" mass="59405" checksum="E78EF8930167685E" modified="2018-01-31" version="1">MAFPFILIAALFPVIALAANNWTEPCHAGECQWNLKSDHASGTMLLSGSNSSISDLTPAGGWTIIDCNATAADQEIRLVCHDPDKCNHLNLNGAENTVVRLPDDCSSEPFAVVSRIWKHTDQSIPASRRSVLQRRGGPQSSVQGITLSTDFAATNTSQHGNVTVFVVGSSMPGFDNLAQAVPGCNTTDAIMHPSQACNVSTVALSIFSGSGSKHGSFSLPATTLQTNLFKDSFSCPQSGAIPAFDGSISVDLKSTVTGSIKYAVTYKTHLFIPDPTSLKLAVGFDAALDGTLSLNADLTGTLSTGAIPLFTAGLPVLDFGSIFKLGPTFNIYAEADASLGTNLEMDVNLAYTISGGQLTVSPSSSPTSGGSFVPGKSNIKLSAGPHVSADAKLAAHLKPTFEFGLTIAGATPASVYLDLDAYAELDLSLTAGVTGSVSPGSKGSNSNSTSTHADVGGCVDISTGLSVDAGGKLFSLSTSITLFKKSFDLFKKCFGNGSGKRDFHDVAYGRRGHARALSPLGHNWRRRHHGHGSSRASAGRGGIVRKSNKGLSCPTSALGALSSIVSETVDVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2I4</accession>
    <name>A0A2G8S2I4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL27993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2I4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2I4"/>
    <dbReference type="OrthoDB" id="2752606at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022698">
        <property type="entry name" value="OrsD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12013">
        <property type="entry name" value="OrsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="68068" checksum="3C12695705F5AF2A" modified="2018-01-31" version="1">MGEEPAGKACKHCQKVFSDSGLYRKHLRGCSKVVTGRWANGLYTVTSGTEGVIVCHCTNPRCAHEYLSVDGFKGHISERYEWKEPKVAGREAGVGREGEGSGGADLELTSAERSAALLGAVGGQRSGEGSSPLVDVGRLREPEGQPSEVGGTPLSLGIPVEVLADGDENTNLGSEPTRSGSSNPAPAPAGRPCLPLAGAPAVAASGLQEGCRKEGEVQEEVSLSESPRVEISSVAGSLDLSFAMGGEGPRFGPSPAGSPELLGSSLDPDLGLYSPSSDGGAEREAEFAHLLHTNAAAVHSGGTPPGPGHQTALPPPPAKQTSRPPVDVGATAASLRMVETHADLDRLHLVYNSQHRFLVCADCHIALEPAFVQAHIKRRHAASQVHVDPAGLHRAVDALGIAPELPRFGPGSEEDGERESGVWTPVDVAERVVGGLPVYEGLRCLRCRYVCGAQATLRAHSGGAHGNHSRDVRSQPCKIQQLTDSGNRSRSWFEVCPELGEGPLQQGGPAASSGELRALGAVYTSLDRPPVLGLVSKSAREVSPWLLTTGWHLRTDGFEPQELRALTCFPREEELPGLALTVRDYLEHGLRLVAGTDTLTLQCLNTEDPAKTWVAHLYAGSAVLTLPSGRLRGVSNTPFHRHQQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2Q7</accession>
    <name>A0A2G8S2Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000029">
        <property type="protein sequence ID" value="PIL28055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2Q7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="19133" checksum="F1207925E74A7AC0" modified="2018-01-31" version="1">MTSGRELRSTWTTWIASRGPISLQVPSSTSLQSPTWRRNQRHPLTQYTLVCASGELRTRKSPCLNLYTGPRVLHLAVGLRLPLSHTVALHIVGGLRPRKAAFAFAGAANALVRAFPVLAISAPVRRHRCLSQNDGMHWQEAGASESWSQARSPSLSVRTSLRAVICNCRAAAGESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S372</accession>
    <name>A0A2G8S372_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_09849</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL27998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S372"/>
    <dbReference type="STRING" id="1077348.A0A2G8S372"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="329"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="81"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL27998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="743" mass="82959" checksum="4609C49FF5F28B7D" modified="2018-01-31" version="1">MPSSRSSSSHTAASPRKDHDLNPLHALAFAASSSSKQSPPQELHILKVTDSLHLEAGPLPEAVLHKVGATLAQHVPVFHTPRESSMDSNYGPPPPSPPSSFEGELPPPRRVASISSSSTSHPDGSPRPPVTFEEPIPVERASSSSREQRSRLGSNTLRHRASAETKASQSAYPQSTLDTAFTDEPAPSAVVVEPAPITLPSISKSLPSRSAPGATTALGAGSHVSVDGYLQPPAPHRPSRRNTIGAAAPPQPASPPRISRMATMHGAHPTSFEDVGELADDIELHAEQIRRERMSKRAKAQQEAERALTRSTTVVKKADEGPLVGNLIGEDHVNYVLMYNMLTGIRIAVSRCQAKIRRPLTDEDYTARHKYSFDIVGNELTPSAKYDFKFKDYAPWVFRELREDYFHLDPADYLLSLTAKYILSELGSPGKSGSFFYFSRDYRFIIKTIHHSEHKFLRSILKKYYEHVKNNPHTLISRFYGLHRVKLPHGRKIHFVIMNNLFPAHKDIHETYDLKGSTVGREYPEEKAAVNPRAVLKDLNWINRGKTLELGPEKRALLTEQLRRDSELLKELGVMDYSLLVGIHLMQRGNRDNVRRRTLKVFSPDMPIISRKKTVSKGPRSPEAIAMRRIMREADPQSLGTATFSLPEEDTGERQHFLFYQDEGGLRATDEANEGMDTIYYLGVIDIVTPYSFFKKIEHCWKGLSADRHKISPVPPPEYAGRFFSFMKAVMRGGEGGTRFKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S379</accession>
    <name>A0A2G8S379_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S379"/>
    <dbReference type="OrthoDB" id="2745919at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46879" checksum="C1CFC43DF543CC8C" modified="2018-01-31" version="1">MERFRSLPDLNFDILLQIMSLSTAQDVESLTRTCRGLRVALAAELPRGEVTLEGRCLASFLAFASVKDGRDRLTYLHKLVLPGSTYGESMSNAGKHAMSIKDVKGALPDLFKLASHSIQSLTILDLDVFSFRPPELKAMLDSLPRLRELEMSRVEKRYQNTLTDTLPHLHALTLGFCSNDTDTDPFLRAPHRAPNLQTLTLYNGILPVTEDAALSFPAVHTLRVCPRQLPCDVDACMRLFPNVRHATLDFPEGYGALAPAFRKDMRPGRPLRAWSNPSAVQARRARFLARVQEARGTGAWPHLQSVRAAGYDAWNIDRAGLVPQKGLARLEVACGQWTWQGETRGQRMFVSVLNELRPRCVVFHPSTFDSADGLKRLRFSPFARSNRSKVREKMAAPLDPINWNDARTAVCDRTRHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3N4</accession>
    <name>A0A2G8S3N4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3N4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="82" mass="9312" checksum="F9A72A7F4E22E772" modified="2018-01-31" version="1">MPHSMTHDLVLRYFDDPLAPDKKWPEDDKAISRAGVMPANNRMGSNNHRHGDGSKRKVADGVEHPLCPRTWRARCKLGVLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3U6</accession>
    <name>A0A2G8S3U6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3U6"/>
    <dbReference type="OrthoDB" id="2763577at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013950183" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="116" mass="12178" checksum="92E66247C3165B1D" modified="2018-01-31" version="1">MKLVAPFVLLAGLAANAVGQSKLTVSVPDHTQCASTVITWENGVELVSTAFDSAWIEKDGAAAPVIVAGSLETTSHPFVNDAAAGFTVSIQLNDNNNDIAQLQYTIEPSSYRYPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4C9</accession>
    <name>A0A2G8S4C9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4C9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4C9"/>
    <dbReference type="OrthoDB" id="2748371at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11882" checksum="A10ECBFF89713D8A" modified="2018-01-31" version="1">MELLSGGFYKGTIHRVVQPPADQRGRERLGVFYFALADDAVRLVPRVESPVLQRVGVQRRVADEDAPTMETLRRSRTAAYGTSTLKRRADGHEEEVLAGMTVTHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S511</accession>
    <name>A0A2G8S511_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S511"/>
    <dbReference type="OrthoDB" id="2681631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18698" checksum="5736977EBBC1B121" modified="2018-01-31" version="1">MSQEFSLDQATREWIQHEIADVFTRLRPLTTGRKHAAPRLAPPEYFDGISPDFEQWKSDVQVYVAGLDKDAAISAVLGLIRGTNVNRWKRNLTQDKFVANGNSWNYTDIAAFWAELTTKFRPINYVNDAIIALDQIHMGSRRAEDFFDEWETLRAVPVKTGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S541</accession>
    <name>A0A2G8S541_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S541"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013782269" description="Transporter" evidence="2">
        <location>
            <begin position="24"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37580" checksum="BE95756402781782" modified="2018-01-31" version="1">MFRVPFALILALASTAIFRVASARITDVVLFGDSYTDQSRAHSISNGTYPGKDYQEVYPPADTAADGGFQWPFYLGLYGNYTIWNYAVGGAVCSNALTPLLGVPDVAVGQQAWFVQDHVAHNGTRSQRLLLDPASFVVILFIGTNDVGINNFVTNDQPAAVSLPDVADCQLDALRALHALGARHFVVNSLIPLQLTGLYGGSSAPVIYYPAPPHNGTAWHREMTNLVQSLNRIVRDGVRALDAEWRAAGDGGSVQWFDTYGFFEEMYYHPAGFFNGSIPANVTGHCHQCPDPDDWRQCGIGDCTLEERDSYMWWDELHPSEQTGRNLAAEMHRKIEGKSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S670</accession>
    <name>A0A2G8S670_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_09294</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S670"/>
    <dbReference type="STRING" id="1077348.A0A2G8S670"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013428016" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="173"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL29245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="331" mass="36103" checksum="120AEE62869313FC" modified="2018-01-31" version="1">MLRAFARLYLVLVQLAVVLPATTWASPISTQQVQGVAAKGYRLLDLQPGVEPVWKTEEDKLELLRQGVHFFDVTEVYDPEEAALSVNIEPHATKANFPAPSHLSDIKPILETLSTTNMQDYLANLTSFNNRHYITSSGKAASQYIFDTVTAFAAGRADITVTKFKHPWAQFSVIAHINGSASPSASAPLVILGAHEDSINLRNPWTGRAPGADDDGSGTVNLLEVFRALVAADFRPSTPVEFHWYSGEEAGLLGSQAVAKAYRRAGTEVRAMLELDMTGYFKPGSKEVIALEADYMDAGETAFLKQLVETYSVLDWAMDAPVRNGLSGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6F3</accession>
    <name>A0A2G8S6F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_09365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6F3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6F3"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="14"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL29314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="528" mass="56310" checksum="0EE1362B2A370620" modified="2018-01-31" version="1">MSHTKRSRAKDFVLIGTVTLVMILNISNATAVSISLPTIGRDLNIIESKLQWIVSAYSLSSGCLLLVLGRLADLFGRKLTFLLGCACMGIFGLGCGFAQNEITIDILRALQGFGPAAAIPAAIGILAHTFPPSQIRSVAFATFAAGAPLGGALGSAIGGVLTQYTEQSWRSTFWFLAGLSAACCLGGFLSIEPDVPYTIPDKRVDWVGAILVTTGLVFVVFVLSDGSIAPDGWKTGYIIALLIVGVLFIALFVFWEWYLERVHARGGEASQKWWTPPPLMPVSIWGRKNGKVAAVLVIAFVQWCSFSGFTFWVQLYYQEYLKLSPILTLIRLLPMPVTGITLNIVIALIVARVSLVYLVTIGTLLTATSNLLFAVIDPAAPYWAFGFPAAIITVFGADFFFSTGTLFIARACLPHEQSVGGALFQTLTQLGTAFGLAISTVVFNATLKSKSNQLGVGTNAGGTNAPKAAQLAAYKGAMWTGFAFGVFGTVLAILFLRGVGVVGHRKGESHNENEKAGHKDTKAIHASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6F6</accession>
    <name>A0A2G8S6F6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6F6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6F6"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="99"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="20118" checksum="2FDC801856FAD88F" modified="2018-01-31" version="1">MPPFQSSLATERGWVDPHALPKYADAAHVAGNAPADAKQLTLNTLGAYGVGAADCFAHAVGRQIRITEMDVNVDRKGDRREVVVVAEVQVTKEMLNGAGLVHGGCLCYLIDNCAAFPLVALGVMQKTNGVGVTQALNVLFHAPASLQTCMRITSTSVTLGGRIMTSRCEVADKASGRMIASALLGKMQPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6U9</accession>
    <name>A0A2G8S6U9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6U9"/>
    <dbReference type="OrthoDB" id="2757906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62106" checksum="5A6FE6D1894055FA" modified="2018-01-31" version="1">MAAHTLAARSLPELPIEVWQLVMDAVWDATTYSTFYSNQADYRSWALVSRAWRTCAQAVLFRTVELSDPVHLRRFAALLGNAPHLAVYVRTLRAYSRDLHTHDNVLALLPAVLPGDVLPNLRSLLVTRVTEQDTWHPHASRPPSDKELAYMPLSTDSAENGGGSFTRGLEAHFAGVSELYLSYVTFETFGALAQTLHALRNLRLLSCLEVRWRALGAMPECLAWKGGDEGKGQGQEQGFLPKLEDLTIAYMDLHGVERLLSALGGRSAALKGLYIDCPHYCPVTFWDPPQPDPVTGTPLGIDLRVFSRLGSLWLALPYALSACRELPEIVAALLRTWAPTKESASVPRKLTLTPSYESDFTRAEFAEVLRALGPVIEDVLGVQSESMSEGEGEDGEKADVKLREDERRALAEVEVEVCVVDKADMREWWRGEARASFARLGARGRLDVTFEKGFWPEAQWLDDSYEQEAEEELLPSQQTSDGGTTNGERGGVESGDNGTSASGGVARRRRGSSRFTSFRPPNKLKPFEAQAFPLVLEEEEGQGRAGGVWFIHLAPCSRVASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6V6</accession>
    <name>A0A2G8S6V6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6V6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="103" mass="10974" checksum="D1BE80A5862DF652" modified="2018-01-31" version="1">MPPAEMAASSAAFMLFRIRLATRTHHYIKELAGPACNALLGLALGRTLTHSFQLLAEPSYACRQSSYTCAAPTRPAPAAKLPLPPRALTTGYKEGPRTCTSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7B3</accession>
    <name>A0A2G8S7B3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7B3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7B3"/>
    <dbReference type="OrthoDB" id="2801156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="894" mass="99289" checksum="11B7EA6C48B31E9F" modified="2018-01-31" version="1">MNFHPFYETIELGSGELNSVTAILEKGRRWMQAPRRGYYDHWGPILRWITDKSTAFVRKDDSDVSSLREDAKAWYCNKGRCLTSEPVDTDDTLWKRLHRGSASIATGELEIQLYLVAPATQPTKVRFDTGVHAEQIRRMYILDYQPVSEELWYPDSDGSDTDKDNSILTRMAALYEPAFAYAQNALQRGLQDVPLSDSGGNHEEEGNARSDGEAINVMVREANGEDNVLDTHLFMAQLRDALNGLKAGCPDSESKENASAHGVALGKVLQLLFDDPTLKVQVKLTGFGRRGGPLPRIKIEAECPTPCGIPALYVVADDRLTSLRDRNPKRKEWGMQESMIAYRDTILITGHFLNPAQRSPPAGFALGAHTLARTEFTEMPCSGRRQRDTHLFMAQLRDALNGLKAGCPDSESKENASAHGVALGKVLQLLFDDPTLKVQVKLTGFGRRGGPLPRIKIEAECPTPCGIPALYVVADDRLTSLRDRNPKRKEWGMQESMIAYRDTILITGRAPIHEATCSPCLVIGTAGAAIRIFAAYFADRIYRTHLCDFALDVDTDSDAQSDAVVATKVRVIRNTARMLREMYTRVHVGAHLLPPNHTCRPHLLPRPAILMPVPAPLPVHLSLLERVTRGQNSYVFTGTLTLHARHGTDDSAESSERELPVHVKFVEEYSVAAHRLLAAHTDPTSGAPRPLAPQLYWAGEVVPGLLMIVMETSPPTRACSDFTPEPQYKPVKRAELGDLRAAVQLLHAHGFVHGDLREVNVMLQRCAADSDASSTSENLESSGSTTISTSTGEAPRAYLIDFDRAGKEGSARYPMGLNPNVKWPRPVSEMHGQLITKEDDMFMLEKMLQELKEPEPEGGDGQDEKAHKRKRSREQDDVDKCKHKRDDTSDKMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Z5</accession>
    <name>A0A2G8S7Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Z5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="108" mass="12432" checksum="974EA1C337CC3C55" modified="2018-01-31" version="1">MSETSLYGTLPLLRPSPWPQLPFWKRLLDAFMLIIVENLDRLLSDLHIVDLSFVSWTRTTQTYCVDPDSGQDESWTWTNPQREKLELNGIVPQMCSTIGGLTGFLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8J0</accession>
    <name>A0A2G8S8J0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S8J0"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1956"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1974"/>
            <end position="1989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1997" mass="222459" checksum="706F659C3867A3A5" modified="2018-01-31" version="1">MAPSGSEPCRFYGTTSGCRYGNRCRYSHDLNQSTTPRGPSSSSGWRSRSQAANSNSSPTLYGVRGGSRPSGLPPNTCQFFWTSGSCNRGFECSFRHVKGPGTTDAEDEATAAQGDGSEGEESVDVDFFSPSGLAAGAGTARDDRLNLTPSEVHNHLKEFLKDDYRFESAAHVQGFVRLLASVNDSNKAWNTENAQELLRVVVKGNSLLRIADILRYEPVDVAIGSLTRTLSFQRGYFPVFQFLASDLVLKSTLHTNINLLYAVIKNNHAVVFATWQKCLRKMLTNASWKDPSPRPAAFYQNNLTGITVFRTLSTVLLQYFNRYKDAIRNNEDMSTFIKQLADWFKTWIDDVSASPPRFEDPASSVPLNKLKLMIAHIREDVDRLIAIVERETGLVQRVAQRGSAISTVTNAQRSQARAAQLVQTYDPPGSLREDGPRHDNDFMEIEQIRIAPTHDELLCAVPPYLPVFSRDAPHHWPADSMQRHLDIQFRLLREELISTTRASLAVVHDDLLRMWSRDRKKSDKTMLEVLIEKNGGAYRTSGYDSVFFQLYTNAEFAALRPPEATRKGISVTLAVDTPSGGAARDKDMRKRVEYWEHAKRLQGASLVALVVVADKTLQVYLGVITSYNTDIAESAKHEQGRIQVQISFFDAEVELMAMRGERLCWGPSNFAVLVDNGVMFEAVRPFLGKLQTIEPTEIPFSRYIAPGGPLDRVQVRPPKYGQVPGFRFDLQCLAKPGGLIAPLDVLNPLAVRRAREQLVRSSILDPSQADAVVDTLTREVSLIQGPPGTGKSFTAKEILRVLFASGIRPIVLIAYTNHALDHMLTSVLDAGITEKVVRLGTRSSDERIAQYTLGELERRAGVSAFDYSMKQQYAIMKQCEEGLYNTMASIRLPLASWEEIEEFLCINYGDHYDSIQFPPPWISRLAQLKWEEEDLQGAFEEVKRKGKKKRTVIKPGYRTMYSIWREGVDIHFLQQTYPARSKPPKGNQGGYDGSSGIRSLLSNPHKLFASIGFYDAIPRVPRTDRSLGLLRESSDVWNMSLAERARLADEWEAGIRARAYESQLEYYRSMKADFEEECRINDEMRDDARRRLLRQTDLIACTTTGAASLTSLLDSIAPKVLMVEEAGQVLEAHILTSLVSSVQHLICIGDPKQLRPTMATFGLSMDSAVGRDLYKFDRSLMERLSDAGYPMSQINVQRRMRPAISHFIRTILYPKLQDHQVVTEYPPVQGMQTDVFFFNHLNKENGTEDSVSKVNMFEVDMVRDLVVYFLRQGAYSGPGDIAVLCAYLGQLQKVRAALRDLKIAVAVDERDAEQLARQGLEEDSEVEMEEVVVAKHVRLGTVDIFQGQEAKIVIVSLVRNSGETDTSRASIGFLKSPNRINVALSRAKHGLYIFGNVANLRQNPTWSTILDDMEDRGQIGFPALTTPVIRASSSFLASTRAGSTARGATLATRSASSRAARNAHIRSVRSLARNRAPHVQSRANGRALTSPARCHAARYAPDFLVTNRARSLFNAGILAPPFVANHAPRRNLCLGDANFGSRDIRNRLIALACGHTFTVQALDLHCGMREYYDVDPTGHFVASKLPSDVRRLPEAANLSDVPRPYYGSALREDHETGRHGHSRAECCEGDLSNYQAQAREIEAETATYAKTKTLVKPSVLLIQSGPLPVENAFSLGAMQRVHGLAVEEARAWRQIVKEIVNTYQGVVKVANARGPHIEMYEAAVSTLLRIEMPEDEDRIRATDVASAGIIKDLINRKVGQARPQADVPFRVEAYFLSLDLRSLLAKIAQARVDGFSNTSNDPDTVRHRGLWTSFVIFLYYSCIADAKKAAALAKGCPTPRHGTRAAVYEAQFAFDAFRCKTVCQRAELSRAGALDGAARERLRCKAADYRRGVAQSLQQLEQSHLRAHPSQTADGLREERRWLEENCRAKGVALERECAKLEEELVTPFDIHMDNRPRVAAQTRPEEDFVRQRPSLAGSTSSAAASGPSDKSSCVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8L1</accession>
    <name>A0A2G8S8L1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8L1"/>
    <dbReference type="OrthoDB" id="2757774at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="468" mass="52392" checksum="A6F2F6E9D97D1710" modified="2018-01-31" version="1">MSTTHRHIHYSLLRFYSRPAHSRGDRCSPNPPLAHRHRLVHERPQSPARGFVPHPHALHPLLLQRRPRVPRDGPPAPRADPPGTQAPLLPPPPKPDGRRARVPGLLPRPHAVRRRARAVRRPARRAPAARPPAALLPRARRRAARRRGGFDARRSRARGRPRGEPTRARQPEPALAGVEEARPRRVHAVGAAPAHPALPDPPSHARPRPRPRRRCGRTPNPSRRGRPPREPRPRLKLTLRYRRDMFDGVFTPELAARLSRLTLCLVCHDDDSDGEDDTADVAQLLWGGFLNTLISALRPLHNLTHLRLVVHCKLVKRPAGSATSLPYSHSESFVDTVRGPAFDFAGTADALVRTLPSLQYVFLTTCGSLVDRGENKSNSGRPSLREHERWNVGRAWRVANADLGQPQGTRKSTTTLPRTDGIRDEDEDPPRGRLVELHSDVSDTIIRNEELVLSDADESLLFPKDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8P3</accession>
    <name>A0A2G8S8P3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8P3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="292" mass="31699" checksum="88ECABFA583BDABD" modified="2018-01-31" version="1">MYLATPVIGNNPASPNSSVDIMASVCRHIPGKDAASCIFFQLPGGPSSPRQLVFPQGSLRLDIPASSSTTSTFPHHELFGAFPHLFSSARELRIHYINDPAMAVLDSPLVSATFPNVATLSVIRDAHRVRQMVGHQRANGTLRAGLAHLTTGTGTIPPPPASIRTSLPGVESAQGEHHDLRYPLLDTLWTTVESSDEITELERALAARAALGVPIRRLVVTLRYSPATAEQPASEGLDDLARLRALDVEEVVVMDGEVSSELREVDWLTRLPDRYGLPSCIHRDWPTVWGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9N3</accession>
    <name>A0A2G8S9N3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_07168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9N3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9N3"/>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="578"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="850"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL30469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1133" mass="122027" checksum="C9F9F043B92CFFE0" modified="2018-01-31" version="1">MAFLFQRPPVAHVRAPSFHDSDVDAARLPEKLWRTLLLPEQAKATLSIARCTGNKGSGNAGLPSITCHGVLDRTIEKLSIPKGWQAEYPHIFLLGHAGSEDTTPTHSVSVTHPLTLSEVIFSALSNDAYAAASSGSAMLEDWLLDGNMILREGATYSLDAATGSSSSSLSPTGPLSYKLVMAAPVQQGVAQRGHTRLFVSAQPTQDGEVPAEDSIPDMVVDGEEDSEPSGSEKGDFEIGEDFLAGSVLRSLALSSPSASVNGHASNGDLATTNGVEPGNNLHLSSVEWTCRARTLQQPVSPVEDESTVFVRTSELSRIGVLDGDWAVVRSIRNSNNYRLVRVHARDDIATSSGAYISPQLLHNVNPTSAFDRKSDVCLRPRSFGSRRPTIPVAKTVTIARVASAFSTVRAHQPLFLDALQRYFKRSTRLVKQGDIIAVGINTDDLLKQLNALDEDDGHEVVDVVEEFAQNDSGANELVYFLVTNVEHSVVPRLGEMSSPDMYIGATVGELGCWVDTAVTRMVQTGVEHSRVPDMGGYLSLAHRVPPPVDLITNQDTSFGKLLALSSAALNRRAVDYHLQLSILLQGARGVGKATVAGWVAQRLGIHLFEVDCYDLIGDTDAKTEGTLQARFERAADCSPCILLLRHIDAFAQSTQAQEPGKEPAVAEALRDCIANLQPSWNLTGFPVVLVGTTDSHERVPPKVLSCFKHEVVFEAPGETERYDILMSILAESTLAPDVSVKDLAVQTAALVAADLVDLVARAKSAAILRSTSGGNAVYDIFSAGIPLTAADFETALGKARASYSESIGAPKIPSVSWDDVGGLAHVKADILDTIQLPLEHPELFADGLKQRSGVLLYGPPGTGKTLIAKAVATSCALNFFSVKGPELLNMYIGESEANVRRVFQRARDARPCVIFFDELDSVAPKRGNHGDSGGVMDRIVSQLLAELDGLSGGKAGADVFVIGATNRPDLLDPALLRPGRFDRMLYLGVSSTHAAQLNILQALTRKFKLHPELKLERIAEQCPFHYTGADFYALCADALLKAMSRKAEELEVTIAKLNASPPPDSPHPFPLTPQYYLGELATPAETEVLVSEDDFNAALRELVPSVSQAEMEHYARIQQRFSNEALNGRQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAX1</accession>
    <name>A0A2G8SAX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_07078</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAX1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAX1"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF28">
        <property type="entry name" value="CCR4-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL30909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="23217" checksum="C3CD620170D2DF30" modified="2018-01-31" version="1">MRQWDLNTGQCVMTMDILWAISHPTAAPGTTLPAHLFPGAAAAAGTFAVPTPPYADGTWELYQDFVGALQFWGYALVSGSGDGAVRMWDMRTGQPHRTLLGHTAPVTCLQFDELHIVSGSLDKSIRIWDVRTGGIFETLKYDHAVTALQFDTRKIVAATGENGVKIYNRTSMQQSTLLTNGHTRPVERLRYMDRYMVSGGRDSIVKIWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB04</accession>
    <name>A0A2G8SB04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB04"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013721935" evidence="6">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="322" mass="36018" checksum="4ECD949F51BD8A77" modified="2018-01-31" version="1">MVNAWLCAVFACSLLLVSPADAAYMPVPWVFTDPKHDPYNPLQYIASNTLTAIAISLVVLVALVQSALYWKYGGRCMLSMLIGEFTWTIGFGIRFGLHSDPDNASQYIAYYLFIVLSPCAFIASEYMLMGRIARYIQSNKHLLIPPQKITVVFVVSDVSTFLVQAAGAGLSISKNSSLSKIGEHIFLAGLVLQLVSFFLFVVVVLRFLFRIATMEPHTWRKDAQQPWHKDWRTLSYVLIVSSIGIMIRCVYRVTELSQGYLGYLATTEGFFYGLDSLPLLIAVAVYVPFWPARMIPGLDQLADVDNLGKDGEEDRGIEETRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB37</accession>
    <name>A0A2G8SB37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07139</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB37"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB37"/>
    <dbReference type="OrthoDB" id="1043025at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="36"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL30970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="415" mass="45880" checksum="AA7E0050E419130D" modified="2018-01-31" version="1">MGTEYHIIGRVLDERVLVDRSVVFLAGSSSNVSIRWQQSTFIGAGSFGSVYLAINLDSNTLMAVKEIKFQETAGLTNLYSYIRDELRVMEMLHHPNVVEYYGIEVHRDKVYIFEEYCKGGSLAALLEHGRIEDEGILQVYTLQMLEGLAYLHSQGVVHRDIKPDNILLDHMGVIKYVDFGAAKIIAKNHRTLQRTRRGSEPPPAVPGQTEVNGQFGVNNSLTGTPMYMSPEVIRNNKQGRHGAMDIWSLGCVVLECATGRKPWSNLDNEWAIMFHIGVATQHPPLPDPGQLSDMGIDFIRQCLMIDPMSRPTAIELMDHPWMLDFREKLENYEKAENVNTTSVPIPAGGSYEVASVARQAAILQEQETELIQAQSPSLSPIQTPESGASSASLSPGLQEKGSEGILGLVSQTNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBB6</accession>
    <name>A0A2G8SBB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_05746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBB6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBB6"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013795688" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="27"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="83"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="144" mass="14553" checksum="AD799B59A7A816F3" modified="2018-01-31" version="1">MFSRALLAAALAAVCGSVHAQVSNCARNYTVVSGDTCDGISAKENVSTYQLATVNNATIDAGCDDLFVGESLCLGITGQDCDVTHVVVSGDNCEAIAQAAGTTLDILLANNPNVDSDCSNIYPGEVLCTADDIIVVSSGSTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC88</accession>
    <name>A0A2G8SC88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SC88"/>
    <dbReference type="OrthoDB" id="10255344at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1355"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1392"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="485"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="653"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="890"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1363"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1392"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1440"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1512"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1593"/>
            <end position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1629" mass="180887" checksum="62BE36985F6AB845" modified="2018-01-31" version="1">MSTWGVGDDHDSEEVRLLKEQIRAKDAQNATLHGEVLKREAELKEVKDSMTEVLIKLRNDADRVVQLEADIKRRNEDLSNERITRANAEAALTTAERKLKESKHSALELQSTLDTVSRQANSTSLGRSKLEQDNVALQTRVRALERELQNKAQAEKTALSRSHGPSGSRSRIQPPTDDSFRIPVLEKEVAELRATSTQQVSELERTTAQLTRARDQLVQVQNEKIATERQFERQLDAARAALEEREEDLRLLQDARGGEDAAAREAGLLERLEMEEQRVAALEDQLARSAGSRKQDTAMLRDELDRTTQMLDDANDKLAAAESKLTQLTRDRESAYRDRDRLQRERDELSENMREAGARISYLELQLSTASQGTGPEEPSTEEHVTTIERLLHSITRIRSERDGLRRDLEFLNVENKFAVQSLEAKLAAASAPVTPSVNSTQFSQISTLEGYIHILEGQAERTSRTTLALAIVAQRTAEHEEAKAARIQSLLDQLSSARESLQQSERRLQERQGAIESLETQLSSSTSSIGEAESRVAAFRTTIQRLEDELARERHSHVETGAALSDAEAQLNQLSQTLTDAEAARDALALEKTHLEADLDAAREELADVEARHASQLASLAVAGESGRGAQAALRAQVGELQDRVQRRTQQIGEHQHDIKRLETNMKLQEERIAEMTAELDVAQSERVAMLEDCRTTREQRDDAMMRCDELEEAMEALEEAREVEVEAVVKVAFAAEAGRRQAVVLARNSAQATSGDRVALEERIRVVEQEKLELSSRLESLAAERDQLVQRTERELTSTRAQLEEATSTTRATDEAKSLAESQITDLHDELEAKDREITSLRNQLAVAQANHEDRQSLEASLFAQEKAAFETRLQEARTSHSELETLHRETVEKLRGVEAELKRAEDELACQLANGAAHSEAEERLQEEIAQVKQEHAKEIQDLEEQIKALDAEIEAAAHLRREADASKQAVEEELAQTKEQLQSRLAEAGESLDAADRLEAELAQAKEGYEELIRNLNGQLETLKNELQEAVYQRQGLEAQHVQATEDLRAQETATSEAQEQVKSLEDRLVELKEVYEEDICNLQAQLEHACRALEDAKASASVSQRDAVDELTRTIEELQGRLTVLTREVDECRSELDEEKAAHARIRESTTAEMREIMAMRDEAEAALTEAEQELPSLRAQLEHAESSLREVEEEKLSLQYQATNLEAEVQRAKSLQRFLESQAAESEHRIASLDAELVELRAKCTSLDKLAQTKEANLAMQSIQHEQTIASLKRELNALRTQPRFEDELAELKEKNAEYEELLRAKCLEIEENDDKFIDMLKEKKKLNTKIDSLNRKVQNLQTKLNAAAEAAAKASSPPPAPPPKHPAVFSPSPAFALAPAPIISGASSASTSRPTPSSRQRVVTAPASRFSPENVAPPPMPPYRPKTPESRSRMTSGSSSSSRPKTPESRPSHMPVFKARTPERHRVPTTIKAEAPSSSSLIGVKRRAPDDFDDCGTVPPQTFTADSAPSGPSADGSAHVQPTTPRLRKALQSMRSGFTPVRHTTSRAGSASPRRATTGGDVAAPLPHTISDVTNSPRAASHSETGKAAAKKGWLGKIKAAPSSQPRGYTSRPPVFGPPGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCA7</accession>
    <name>A0A2G8SCA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCA7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013863108" evidence="1">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="108" mass="11877" checksum="21F080CED86C8C5D" modified="2018-01-31" version="1">MFSKLPTLCVILLFAAFVTAAASPNRLPRDVFTDPLVAATEAETDAVLEVTEEVVNNAFSLAGEGFSLGKYWNSQGSRYRDGVVNFGIEEMPLEEQKNEEVYIRAQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCA9</accession>
    <name>A0A2G8SCA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCA9"/>
    <dbReference type="OrthoDB" id="2755270at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="73" mass="8051" checksum="C33D24FE382EF2AA" modified="2018-01-31" version="1">MEVAAPRPPVTEAEDKKASKPSSRTGPIDATESPQMLRPPLRKDRRPSLLEQIKQLGTPGHRRRDSEPGKKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCD7</accession>
    <name>A0A2G8SCD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_05946</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCD7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCD7"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="400"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL31248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="607" mass="67149" checksum="B3D6B65280145271" modified="2018-01-31" version="1">MAAEGGVRKRNNAEKAKAKAVAADQAGEKQPAAAENGATKEGTKAARGSGGGTGAGSSSFGTLLVVVLLSVVCVFVYRDPSLVLDPLSEFLGLEETGQVPETRSFTADVEKRDAVVSAFKHAWLAYERDAMGDDEYHPISHKGTNLTEAGGIGYTVIDSIDTMLLMGLHDEYARARKWVETKMSFERDANFNTFETTIRVLGGLLSAYHFSQDELFLEKAKELADRIMPAFDTPSGLPTSMINLGQRKGAMSEDNQNLVSTAEVSTLQLELRYLSYLTDNDVYWDAAERVMRVIKGASLTTGLASIFMNPEDGRFVLSAIRLGSRGDSYYEYLLKQYLQTNLSELVYQEMYHGAIDGIHAHLIKKSEFARLTYTSELVPERGPSGQISWRLMPKQDHLVCFLGGSLMLGAVTSGAHALPVSVPPRPGQLTATGKRDWNTGVELVETCMRTHDTATGLSPEIVHFRIPSDNLDLAVGNMPQDWYIKGAKPGAPPVYDARYILRPETVESLFLAYRLTGDEKYRRYGWDIFSAIEKHCKIETGGYASVLNVDAVPVEHEDKMETFLMSETLKYLYLLFEDDSVVPLNKYVFNTEAHPLPIFNPTRHANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCI0</accession>
    <name>A0A2G8SCI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCI0"/>
    <dbReference type="OrthoDB" id="5372118at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013653">
        <property type="entry name" value="GCN5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF1">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08445">
        <property type="entry name" value="FR47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="209"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="363" mass="40474" checksum="CCB34A4CFFDD1840" modified="2018-01-31" version="1">MPGLHADAHSQSFVLQHLTADDFLTFTYPTLRRHEASSNIVLAHALKRVGAEAAPNRYESTSEDHVAALFATMARDRYTHRPSNDAFWLTLWSVSPQSGLPTLDLVLSCVNWSLGDYPIFLWTPHRASAASSTWLVPRIQQITKHLLDCVPPERVFSVFGLTSLVKTFSRVWTQATGFAIEPEPFYAALHSYCTPETFRQRDAALPQGHQLRKAKMADQEAVAQLCKEFADDSIYFPLSIERARIEARELVSKGLAWVYDASGDITTICAATRNSPHVAAITKVYTTPRWRRRGCAELLVRAVTAQLLFDFGKEAVVLYVGHENSAQRVYDRVGFAGLCGKPKPDGVEDALELGFVGADRGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCI9</accession>
    <name>A0A2G8SCI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCI9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="107" mass="12057" checksum="3AE41C612684068D" modified="2018-01-31" version="1">MSREGARDEDESFEDMLGRCFVCELVYDSCDWRLLERVCALGRYSGSGGLRGMSTRVIVEDTPDARFMTWDSSTTLPLRRCGSASVSLLERGADMDDCEECVERLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEE1</accession>
    <name>A0A2G8SEE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEE1"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL32142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="203" mass="22967" checksum="8B5FF4C65413D3E3" modified="2018-01-31" version="1">MGRVLLKVIILGDSGVGKTSLMNQYVNKRFSNQYKATIGADFLTKEVMVDDRLVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNSAKSFETLDSWRDEFLIQASPHDPENFPFVVLGNKIDMEESKRQVTQKRAMTWCQSKGNIPYFETSAKEAINVEQAFQTVAKNALQQEQDDQLYVDYPDPIRIDSETSQNGGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEI1</accession>
    <name>A0A2G8SEI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEI1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEI1"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="629" mass="66883" checksum="1A1E8A54673251BA" modified="2018-01-31" version="1">MSLQSALIGFLMSKLLRKPMSAQENVVLQTTAVATGTMPLAAGFVGILPALGLLDEKRDGVPPVHLSWIAAVGWSCAVAFFGVFLSPPLRKQVIIEEQLAFPSGTATGQLISVLHQLPPPDTTLRQRRGYNALASADNEDEGVPAQETDALHRSGLGSDMTEVAAVGEQEGWNALSWSFAASGLMTLLAYFFPAVFTIPLFGTYLATEWMWTFTPSLSYIGQGIIMGFPTTLSMNLGMLVGWGILSPISKYSGWAPGPVGDMTVGARGWILWVSLAIMCSDSVVSLIPVVVELFQEKVWRTFRGHSGDDMAPESKEIETEDRLVPMSWVIWGLGGSIVLGTVLVWLVFGDEGIKPWATVIGFVMGGLLSVLGVTLTTTALWGRSVRALGETDLNPVSGLGKISQLFFAWIQPGNIVANIIAGGVAEAGAQQAGDLMQDLKTGHLIRASPRAQFYGQLIGSCLSIVVTTTAYTLYQRAYEIPGPSFPAPTAFVWLGLARLLRDGELPAKSGVFMVLFAILFGFVAAAKTSAVRVGWPYAKWIPSGVAFAIGFLNTPSFSLARLIGGVVEHVYYTRVGRENGGIKLIVIASGFVLGEGVVSVVSLILRTFGVGVVSCWGCGHGMCGGCPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEI6</accession>
    <name>A0A2G8SEI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_05429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEI6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEI6"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="309"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL32184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="394" mass="43214" checksum="65D73970B3257B6A" modified="2018-01-31" version="1">MPPKKAPAADKKTLLGRPGNNLKIGIVGLPNVGKSSFFNALSKTDLGKAANFPYATINPEEARIPVPDPRFDWLCETYKPASRVPAHLTCIDIAGLTAGASTGAGLGNAFLSHVRAVDGIFQVVRAFDDAEVIHVEGDVDPCRDMEIISTELRLKDIEWVEKHLEGLKKTGRALGSNSLADKARKEEIATVQKIYDALTKDNKDVRKVDWVGKEVDVVNGLQLLTAKSVTYLVNLSERDYIRKKNKWLPKIKAWIDEHNPGDPLIPFSVSLEERLALMASDEERTEEEKNIGANSALGKITTAGYASLDLIRYFTCGPDEVRAWTIRKGTKAPQAAGVIHTDFENKFVCGEIMSYTDLKENGSEAAVKAAGKLKQQGKTYEMIDGDIAYWKSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEL3</accession>
    <name>A0A2G8SEL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEL3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEL3"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="50"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="425" mass="46961" checksum="0091CCA72F8C70F5" modified="2018-01-31" version="1">MQAIARPLARIAPKHVRYAGSLSVWSTVPAGPPDPILGVTEAFKADKDPRKINLGVGAYRDENGKPYVLNAVKKAEETLAKQNPDKEYLPITGLPEFTASAAKLAYGADSVPLKEGRVAVTQSISGTGALRIGGAFLGRFYPHVKTIYLPVPSWGNHTPIFRDSGLEVKGYRYFDKKTVGLDFEGLKEDLRAAPEKAIVLLHACAHNPTGVDPTPEQWKEISDIIKEKQLFPFFDMAYQGFASGNTTRDAFAVRYFVEQGHQVAVSQSFAKNMGLYGERVGAFSLVTSSPEERARVDSQLKIVIRPMYSNPPLHGARIASTILRDEQLYGLWESEVKHMADRIIQMRDRLYDNLVSQNTPGEWNHIKKQIGMFSFTGLTQPQTKALAEKAHIYMTADGRISMAGLNGKNIDYFSESVSKAVKGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFD7</accession>
    <name>A0A2G8SFD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05198</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFD7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFD7"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="521" mass="58050" checksum="4677CEBBF562D3E6" modified="2018-01-31" version="1">MSSGSELTDIDEEEELSYGAPTKSKTKGKGKGSASEGGYKIRGALRPPRATTYTCQSLYDQIHGQDIDLQPEYQRDVVWPEKKQIGLIDSIFRNFYIPPVIFVVNAMDDGGERRVCVDGKQRLTSIYRFIGGEIPFKDAFTGERFVFKDTGKIKAQILPDRYRKLFLNKQIVCMEYTDISPDNEREIFQRVQLGMALTPAEKLQAISGGQADFIRTLLDTYVNDELSNSIPWDTSRANDFRGLATAVYTMSRWPKVTTLPSLPVIEAWLQEPDELDEDFCDDVHNTYRIFCAMAKDPILNKPMWLSGVKKVAPVEVMGITILIHARKLKLTMAQLSEAVGLMRKDVRKNEKDIRQNTRTMKIILAFIKELKTEKLKPDPTSPVAIDYPAVSTKAKVKRKKVVNSSSDDEEESRPAPTIRIPTPSRPSTSTSASNTSTAAPTPAPVRAPPTAPSALRLNGSGLPSRPTSTAAPPPQISTQRNNSLSDNLMARVMNQSYDASRDPRNPAYQSLSSASQARARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFH5</accession>
    <name>A0A2G8SFH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFH5"/>
    <dbReference type="OrthoDB" id="5592585at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="166"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="794" mass="89367" checksum="A492F0C188D584DE" modified="2018-01-31" version="1">MSASAPVDAEETPCYPRSADSVNNSTGKVPLKHYRRQSTIDLSNRSVRANSVEEFLNGLLPFRPGRNSNLQRPTLATNPFEELEDADSLVEAEVVELFVDAVNSRGLIPGLVMARCENRPDPRNIDTTGQKIDAAFYHATNAPDDDCPHWADQAGCAEFKSGKTGNGKDPWSDVKGNPEPDAEERETNRGQAMTFAELVHAIQQRVFLFMLYVIGRRFRLLRWDRAGVIFSPLVDYFENPEPLLEFLWRLSHLGDTALGLDPSASRISHTGRDWKIMDRAAEDARYDFDHHERDLAVGEVVPEGFAWTYVREMFADSIADPEWPRYKLHVNVAPKTTRAFLVGKPVIRADGLVGPGTRWYVAFDCEERRFVWLKDSWRASYELVETEGNILATLKAAGVEHVPTLVCHGDVRKQVTLTAQWWIAQNPKDTAPEQAPPRRRRAKGNPQEQASAESGYRRDCPVRQLAHYRLVTEEVCMSLDQFQNGLQLVSLVLDCLTALHGAYENSSEKRLHRDVTDRSVLIYPKIETGKTGAKFIRWRGVLANWELSKAVAAALIARQPERNGSWQFMSVNLLSLSPMRFSIADDLESMVLVLIYHAIRYLSSSIEKNLVVANHLESCFDSYTVGGCKVLCSERKTETVKGGSLFYYLPGIGRRNLVFGSPLDELLGTILAWFSSHYKVTTWEAHIALHRSLARAQTHFQTPAKSSRSHSGDGLPRRQDEEPEPPLPPVPTPEDRELATKTSAHSSMISEFWNTIQSERWSARPSDRHSDRDRVPAGWLSKLDPVPNVSGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIN3</accession>
    <name>A0A2G8SIN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIN3"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="678" mass="75110" checksum="9815812D650789F3" modified="2018-01-31" version="1">MEPGTEQIALYDEAILVFSEDVTFTGVWPSGDTSREVPGRLILAKFSPTIFVVMVFTRTGRVASGTPFCTNIVTDDTVFEFSEPVPTLIHASVPQKNSRARIVIDEGRALHGVAIGNTLEIRFPRATVMWQFCSLILEVKLCLADHRTRLDALLDSVIAENYGEVMYRLRVSRIVSKSRMDDYLYAALECDMFDVNSRKEAEYKRRDRLWLIASRQAALLAFAFFDVRRRPPPILESCPGLAKVLSRIDGPGESLFALFASTRAAASSHLPIVPYNPFLPYQSLSPPFVYSAKSADVPTLDSCKNRHRTRHQPDVGAYGIPKRSRRPCVAGRDALGRFDGRAEPYSEELSSCRKTRWASPTLSADGVGIGGMVSTILHPDHPTPSALFVRRLMLYCSVEVDAANEGQRCARFGSSVSMDDVGSSIVSFPDSDSHSEADVDLCAESEDSLEDLEDGLESGRSVHFLRQFSATSGGHLSDNPRSGTRISWIVSSLADIAPNLGLPSRSLLLLPQEQSLPPYPKSRYNRRVPDSSSAATSLPRSPHQQDVLLRRDRSIILSIRTKDQNACVVQQAFCPVRYKSVSRKLAKDGAYVQYIRPRGNLENNFTRNYDQGGVDEGVDDRGDGPSVSDLHRPRSRVEVSGLYIDLPVFNSPAADPFYPEKETATVHKLEAREVSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIP3</accession>
    <name>A0A2G8SIP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIP3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIP3"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF13">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="403" mass="45016" checksum="5E4D243486C92043" modified="2018-01-31" version="1">MSPFNWPAILSSDYLLASLLPLVLFVLSLQILGRPADLLDIILGRTRRSSPASVGHFSVQRAAASYAQYAKLARAELASMRASYQRMSWAHRRTGYALGYPRKLVRLEESIGTNAVVAKAIARLAREEFDEEERGLLAPGIKGDLGRVRESLKHLVRDWSEEGRGEREVIFGPVLDVLRACPGEKRAGKRVLVPGAGLGRLAWEISELGYQTTANELSFFMNLALRFLLSPSETQRPNQHVLQPYASWFSHQRTTDTLFRKVSFPDVVPRLSDDFALAERDFLSLRAPEGTPGYDFVVTLFFIDTSLNAIETLEHIYALLRPGGRWINLGPLLWTSGGQAAVELSLEEVLKLAEAIGFDFAGNGGEAAELVRRRTVECEYTADQTAMMKWLYQAEFWVAAKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ63</accession>
    <name>A0A2G8SJ63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ63"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="111" mass="11970" checksum="BCED805376374094" modified="2018-01-31" version="1">MTPSIMAAWVMKSLFPSPSSSSSWSSATENRLPVRVARRGARRLMGVDGTPSTPDWTGVLGTASRAEMPSAWLWLAVSVRSGPCIWAWSLSAACCWRPATVESLSGPWTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJA5</accession>
    <name>A0A2G8SJA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJA5"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055323">
        <property type="entry name" value="C57A10.07/YOR238W"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28110:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41437" checksum="61A6B32837280736" modified="2018-01-31" version="1">MLPLPASFSRTHPRRPGYGIGLGTGLTVRKAHYRSTRDVLLSRARVTNLGFFLLAGFAALSFLLNVFHYFADDRRLNGDLNLHGLNVNAAPRGIWETLARDRTLREIDHLIMVPGHAIWTGRRVEERMDEDAWVLESYQRGGGRVAAFFKHIAGGAQMAAEDEHSLLVFSGGQTRPSSTTTEAESYLRLAAVSGLLPSFPKSQSKSTSPPLVRATTEDYALDSFQNLLFSIARFHEYTGRWPSKITVVGYEMKRRRFTDLHRAALRWPADRFEYAGIDAEGEDASAARQGELQNGYLPYTEDTYGCHGILLAKRRACNPFLRHHPYYSSAPELAALLNWCPGPSDQEHGQDQTAVFPGPLPWDSDGAFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKT0</accession>
    <name>A0A2G8SKT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKT0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKT0"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="581"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1069" mass="118330" checksum="4FD2C85B32AA6B7A" modified="2018-01-31" version="1">MPLLSAQVPKGVNAEFKVMEGLIERKDISIPQMYQWNAGENPNFPLFIYDNGGKLEYITYVFANAAMDRVARYVLQSVGRSSTTFAASRPVIAILANTDTITYFCTVIGILRSGCTAFPISTRNTAAAVADMLSRTGTTHLLVSPDVVTGGIADEALKSLAGLGVHVSRLAMPVFEDLFPNEVDSASPFEADVEFPTSYDMESAAVIMHSSGSTAHPKPITWTHAGIFHWAKGPLRSKNDIKGSIMGWHGVPMFHGMGLSMCWAAPMNGLVIAAFKPASPPTVQTPDAVWEGYAATNVDFSLGAPSLLQQWARDPEKVQVMKRRRGAFYGGAMLDEEVGNRLAAQGVSLFTMYGCTEVGLMNRYATLDCLTDWVYWSVSPGHRLYFRPMDDGMYEVIVLSSPEFRLPCTNTTIDGQDAYATNDIVAPHPTKPGLWRIVGRADEQIVLSNGEKTNPVPLEKFIDSDPQVRASLMFGRGKFQNGVLVEPAPGFALDPNDARQVEAFRNKIWPTIERVNGYAPQHSRIFKEMILIASPSKPFQFNAKATPRRGVILKEYDEEIEAIYKAVESSAQSDIAPPTAWDETSTLDFVRAIVMGTLSRSLSNDADIFRNGGDSLQATWIRNTILRAVRETDQDAAKRLPMNLVFQSPTIASLARAVLSVLHSAPRPEAAHSPEDLWKYVERYSANFPSRPSDLVERPQGKDVVLITGTTGGFGCDALEHLLRDDNVARVYAFNRRGTQALDRQRAQFIARGLDVSLLDSPRFIMVEAALHEPDFGIEHALREEIRTTVTHIMHNAWKVDFNLTIPSFETDIQGARNLVDLALSSRFVTPPSVVFVSSVGVFRTPIPEIPLDDPASPFGTGYSEAKWVVERVLQHATQRAGLHTVVVRLGQVAGDRIGRWNEREWFPSLVKSALFQKCLPEHDGKVTWFPAYEAARAFTEMRHSPEPIVHLVHPRPVSWQSLLEPIAKELNVPLVSYTQWLSALESSVEHGSAQEVEAMRLNPALRLLPFYKVQSTAMTPEREAMGLAFISTDKAVQVSESLVRMPQLDGERARMWVAAWKKSGFLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLA5</accession>
    <name>A0A2G8SLA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_03308</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLA5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL34530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="543" mass="60476" checksum="56A44AF0DFEFD9EA" modified="2018-01-31" version="1">MMAYFSLAAIAALVYLGLKIFRNYLFRSPLDNIPGPPPASLWTGHFPQLLDRKAWKFTAHTAATYGPVSLLKGLFGRRFLLIHDPLALHAVAIKEQEFYTKSVTPSNDLKLFLGPGVLTTVGAQHRRQRKLLNPVFSVSHLRNMTHIFYNVAHKMRSALATRVPKDGSGKVLDVNDWMARTTLEMLGQAGLGYSFDNFEEDSIDPYGESIKMFFPIAKFGFIVEQLSWVCSDAALMWLLRLVPSENMRRMLKIVDTMREHSQRIIDEKKAALEKGNDALEHAVGEGKDIMSICLKANMAAEEKEKMTDEEILAQTSTFILAGMDTTSNALSRILHLLAQNPSVQEKLRAEILEAQGGAGSDANAAIPYDDLNKLPYLDAVCRETLRIYAPVVLAGRLAAKDMVLPLATPVRGRDGKMMNELVVADGTGVLLHYQGSNSTLELWGDDAHEWKPERWLAPFPQALEEARIPGVYSNLMTFSGGARSCIGFKFSQLEMKIVLATLLSIFAFELSDKEITWNSAAVMYPTMGEESMKSEMLLRVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLC7</accession>
    <name>A0A2G8SLC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLC7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLC7"/>
    <dbReference type="OrthoDB" id="3256367at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37651" checksum="39E9AB80CACFBC63" modified="2018-01-31" version="1">MESLPIELHTQIFEFACTDDGATARALALVSRYVRDAASPFLFQSLSVSGLVQMDALVARLHTLPPHARRIRHLFLSDWTRKEMLKGGAPFAEMERYDRERALAARILEYASPTLETLALVAACPYTAAPLVGHLFALALPHLEELSIHGFYPFPQSQSQSQSQSQSHDNGGLPRLARLHLSGNRNPHGLLQLGALEAACPALTHLRVSEVAGAAAFAREVYEAALPRPPTEEDARQGAALSVSLFPSALPARLRELVIEARRPPEPAPNSNQHRHHHRAGAKRGALGAHEKMMTLLREVELRRAETRLEKIEIVEGDGADMFEVLRSDWLTRLQPQRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLM5</accession>
    <name>A0A2G8SLM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLM5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="17607" checksum="651C9BA82363B2F0" modified="2018-01-31" version="1">MNDAPLQNLTHYPPLVAVRPTYLTPRFLAAPAIHYSRSTTSSDYVLSISIAIARLLRLGPLFISNRWAHNRVMLRVDHSDIDIYPPSTAAGFFRASQFLEWYKSRATTPTEENCDLVLILVMSHLIEKEVVVNLGHLANDRHEFAHPDISLLCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM07</accession>
    <name>A0A2G8SM07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM07"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="290" mass="32647" checksum="50DA4B723953E9BB" modified="2018-01-31" version="1">MSSSPEPVMSMAKIPDWLLTHPELRKRGLVVHEPSLQPTEWCSEGPVYVVKAINPSRPEADMYELLDRHSDSPTDHTVPHELIRGERPLLVMPYVAGVEFIITNKSSSILAVFDQILEGVEHMHRLHVAHGDIFAPNVVAATEEDARRDARLTVGRVYLIDFETSQQFERGPGVQTAVPLPNTHVVPPLNMKVFDPFSWDVYCLGVTLEVLVQRVFGSKPADKPWIVCRFAGWLKGNELGCTSVCHCRPTVSKARRVLAVVRRFVGVAEFFTAIFTYPISLSFYKIPQYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM71</accession>
    <name>A0A2G8SM71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tc1-like transposase DDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM71"/>
    <dbReference type="OrthoDB" id="6511194at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="82522" checksum="B8FB9CB390A97979" modified="2018-01-31" version="1">MSTGRKRGLSRTLADMGDAVRRKVTGFFGMHGNHGDRAGQALDKENQPVGGSNLAFPRTPDGSQDGGTPRRSLASLVLQHADSTFAEIATPTWSERGASPGPLTLSRTPSLQSLPPGICSGSAPTGSLTALPGSGNFCPSQAVPHHSQARVRQNEEPTNGHQPPPTREVARHALDDLKALLRPRNNTGKRRVEYKGGDVLRERIERMKHFLALYLLGFEWQEASAVAEEAKHHREHKAVMVRRWTRAFIADRHNLPVSLAGTTNVSLLDDEALELAVVLHLQGIGKNVRALDIVDFLSELDVQARFSLSDTVSLSTAQVWMHKLGYRWKRVSNGQYVDGHEREDVVAYRQDVYIPAIQALRPHLRQYTPDGEEYTPPGDHTAPEPGEENSPARILWQDESVFFANDRRELRWGHEDEKATPRAKGNGASLMISDFFTAEDGWLCSEDGKAVVDQFQKAGGIAKKRWPGEKLVMVVDNAPTHQKRADNAPSARKMTKGPSHNFGVKVPHLDDNGHQLRHPETKKPLMKTIRMANPVELDGTTVTQALYFPDDHPTPELRGAFKGMVTLLEERGYTNVDKLLAECKNFKCPAPPPGSSPLEFYTATPCCCRRLLYEQPDFRNVKSVLEIEMEKMGIQVVFLPKFHCELNPIEQCWGHAKRNYRLKPASSKEADLERNLIDAVDAVPLESMRRFFTRALRFADAYAKGLSGKQAAWAAKKYRGHRVIPDTIFEELTANDVNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM74</accession>
    <name>A0A2G8SM74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM74"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM74"/>
    <dbReference type="OrthoDB" id="2797114at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="497" mass="53651" checksum="ECFD1637788F614C" modified="2018-01-31" version="1">MASSLSVTFNPDPVGQQKDDRFVQLEGKNLEGYEVPQGPHTRSVESPLPKRKLGTSIRLNVSVVALAIASEIRAVANAASSAVAKVISCSPSRASDQHAGRDTLRTPVFIGLGDNAYDVSNEDAPLEDDLLDALDDTQAAVSTITKTSFPTSKRAKHNQAHKKKQRLAEAIRQKQAGVQLMKSSLVSVVRNVRAVFVNVDLGLSRHTQSGVPPSPVTFPVTSTGFTGHYVPPVPGDNKASTAPQLYQQGFSVLEWDGREPHALVDSNDRVFMMLAGSPKDEHGWLAVRHAAERQMRRLAATFKFAKSPKTSRRGNYRSVTCGILFGGGQPKPMNSAVASRNDKIVQETLGHPAIRRIVGFINGAFKLFAPAVHAEYARTLDGILASDESLVRLFPNGVFAAATFNCGRRVATLPHTDSHNYAPGWCAVMALGDFNARYGGHLVLWDLKLMIEFPAGAVIFLPSAILRHSNTAGVYGGGQSVGFKHRRTSSVEEVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMB6</accession>
    <name>A0A2G8SMB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_03499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMB6"/>
    <dbReference type="OrthoDB" id="2734608at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO-type" evidence="9">
        <location>
            <begin position="158"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL34718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="275" mass="31325" checksum="45DC5C3AD9BD9633" modified="2018-01-31" version="1">MEASPMFFPGREVTIQTQAPERTLTLTIDRPFAPFTKAVVLVARSPELGPDPVVVKIYDPRFLDERLIDVEYHPARPWSLELERAVDAIWDEPFHRRFLHDDPDDPKAPEVIAAQWEKYFRMLSTDCFESECKAYDRLRFLQGSAIPRLLLTGTVLPPDERAMQLSAVVMEYIPDAVSLCDVPPDVVTPELCATLLQVVDSFAELGVVHGDINWNNVLFTPRERPTRVVVIDFACGAVRGEDQDDDAWQENLVWGNDSWCMRRMLEKRGISVPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SME0</accession>
    <name>A0A2G8SME0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SME0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SME0"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013970381" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="137"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="587" mass="63799" checksum="B196486F1DF0D1C7" modified="2018-01-31" version="1">MLVVRRALPPVLLFSLLGFFNPDRTSAVAEPLNNDASSLSSAFAHLNAMVGGRLNLAVPFEQACFSVLDGQHANASAAACADLQANYTDPLYRVTHFSAYMFPQWETCQSSLGTDGCLLDSTNPSNPLAFEGMDCRLGNVPPYYITVRSAADVQAALAFSNTTGVRLSVKNKGHDFSGRSSGRGTLALWTTELRNISYNAEFRPEGCSANTTYDAITTGAGVLAQDVYAFADSVNRTIIGGYHQTVGFSGGYLLGGGHSILSPVYGLAVDRVVEIKVVTPDGVFRTANECQNQDLFFALRGGGGPAFGVVIEATHRTEPQLAIQAAVFSFNPTGTDLADWYSLTIDNALAWVNDGWGGHIMGPTLIYVNPLLNTTAARASMQSAIDFVSARNGTTIVEELPTWLAFFEKYVITAEATVGYERSASSRLLPSRLFTNASTLAQLRSLVADVLPFANPYIIAGTPWLYEPAPGAAGATSVTPAWRDAVWHLLLSTSFEYNDTLAEREGRYRALSAHIQGFRDLAPESGSYFNEGDVYEPDHEVAYWGAENYEKLLAVKRKYDPDHLLDCWRCVGWKGEDDDLYQCHIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMR4</accession>
    <name>A0A2G8SMR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02837</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMR4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMR4"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="8">
        <location>
            <begin position="243"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="47637" checksum="D753C774032A2964" modified="2018-01-31" version="1">MPDLTVSTQVRGGTGGLKVSEEMRLLLSLPEPLQLDCGGQVLRTLYQRGSKPLDPRLLNDFAQRCFYGDINGIKRVIENGTAPVLTGVETPYRWGYATLVVLGVQRVVAAPHRSRIDHKATLEYLLDHGVPADVPDIVGYTALQHACMNHPCPDLVRILLGHGADPDHQDKFGSVALISACQNNCVGAVEALMEYDARMDIEDADQCSPEEFYVKCGPAVIAAIQKWKRKRVGESTALDERACAACGEEATRLKFCVACHAIRYCSKECQRSHWFLHKTRCIPFSPESTVTLTPFYEDIGPVASLADMTRQAYGFRVDKQPARNSRSVKIPYIRPGETKKVIIKVQVPFNLDTGGPTTEEVGDMMVYDKKRSFVCRLRRQDGEEAYLRLSRTVRAHGVAGAKAYFSAELRSKDELVVKYKEVLGEQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNC3</accession>
    <name>A0A2G8SNC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNC3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNC3"/>
    <dbReference type="OrthoDB" id="3366231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="24"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="676" mass="77236" checksum="834549C9A798EB5D" modified="2018-01-31" version="1">MVTPPANPDTSQVWHYRGHLLREERFAIFGWLTNEYVVDMFSRNLETRMAFIRENQRKIQEEDAAQMGVDFVEPNENVYLPASFLGSNRWASDQIADSLAIAAAYGPPMFFITMTCNPDWPEIKARCRPGQTFRDVPVVVCRVFKQKLTMLEHDLRTMFPNAGGVEYLIHSIEFQKRGLPHAHILICYSNDCILPDNIDSVVSAEIPDNPHDAELIREFLVHEHKPYCSPERPDGTRAPCRFHYPKPLQQHSTIDSTGHVHYRRRKPEDAWVVPHCLPLVRKYRCHMNFEVASTSHIFQYLFKYIHKGPDHAKFAVVADHSASDPSAAPTHIDEINEYWDGRYLSAAEATWRILGFHITKKEPAVSALPVHTYDRRMHYRQYGHQQQSLSLLERYFRRPLGTFIQPNGDSRSFDSLTYSEYFTLFRLSTWNASNDDRPLYYNESIHDSAPPLHVIQRQTSHPHVARLHTARPTEGERFYFRAILRSRPVRSFVDARTVDGIVLNSFQDAANALGLFADINEGELALTEGINSLRTPFQLRVLFVHLLVNDCLLSPRAIWMSHSQPLSLDCIDRRDGVAALGEDDALDHIASLLEEYGRTLDDFALPHPSQHSTEVAHELARWNLIAHELGMRAHTAIAQMNTDQLAALHPILTAVQSNTPLLAFIDGPSGTGKTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQK9</accession>
    <name>A0A2G8SQK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQK9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQK9"/>
    <dbReference type="OrthoDB" id="10249612at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006742">
        <property type="term" value="P:NADP+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03429">
        <property type="entry name" value="NUDIX_NADH_pyrophosphatase_Nudt13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050241">
        <property type="entry name" value="NAD-cap_RNA_hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049734">
        <property type="entry name" value="NudC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904:SF6">
        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="11">
        <location>
            <begin position="82"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL36057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="262" mass="28666" checksum="EF0DBCE7630D4A46" modified="2018-01-31" version="1">MHFTEPRAAMGALDVFEAAIFAEARTIVDWNARNKFCASCGGSVHSTWAGWKLTCSTLLPWAEDTGKKPCATATGLHNFSHPRTDPVVITAVVDETGDKILLGRNKKWPKNFWSCLSGFNEPGESFEDAVKRELWEEAGVKVWNVRYHSSQPWPFPANLMCGFYATANSNEPLRTDLDNELEEGTRITQQEHREIAASAENSNPNANPDAKDVKSTSAPAQQSSSAPPFKIPPLTAIGGVILSEWAYGRAGPQPVNPKLGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQV9</accession>
    <name>A0A2G8SQV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQV9"/>
    <dbReference type="OrthoDB" id="3246365at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39373" checksum="A8A5913D2D1793DC" modified="2018-01-31" version="1">MAPAVEEEVLWLCGIFPIPLLSPRLPNLRRWEIRDGTTRISSHEWSLTFNKATLIQLLYSSASIEELSLKALRLTSAAELVRLLGSFPKLRCLVWDNIGFNLKRSNLHAGDALFARNHLPGLTTMDLSVGVDIVPVMHVILEVTHPTLQHLTLRQPKDTDFASALPPSPSRPALTQLRTLTLHTRHDTNVHLNPFDWLSLLYEACRTLHEFKCTPTLTTFAIHLRFGAVTHAPRRRSPKPSQLGTVVSRALRFLHDDARCMQLKRVLHDHARLELFTVVLHLPREEKKRWPVLRHLKEQGFFALHWMGLLGVDGSSGLCGKQPPEPRDVMTTWALEVVPRRLAPSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS04</accession>
    <name>A0A2G8SS04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS04"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS04"/>
    <dbReference type="OrthoDB" id="3049716at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="52"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="22712" checksum="C235679F36D4E753" modified="2018-01-31" version="1">MSLPSNISLATDATITDDPNSVPDWVQQLDYVALAAVHSGPVALTSNDAHPWYLDSGASMHLSPIKSNFTSLRPIAPHAICGVNSSVIHVTTVGTIKCPLPNGHILELINVLYVPTATVCLISIRALCDSYSNYTVTFSRSGMSLRSPSGNLLFQASRNSNTMFTLNMASPSSSPSTAFIVTHRSNIETIHHHYSHPSYSIAYNIAKHYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSU2</accession>
    <name>A0A2G8SSU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSU2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSU2"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047046">
        <property type="term" value="F:homoisocitrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009085">
        <property type="term" value="P:lysine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000019">
        <property type="entry name" value="Homoisocitrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF48">
        <property type="entry name" value="HOMOISOCITRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="7">
        <location>
            <begin position="18"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="360" mass="38617" checksum="669B7993ABDEE911" modified="2018-01-31" version="1">MFRTPMRQMATAARQSLKIGLIPADGIGKEVIPAAKAVLEALGSDIPKPEFVPLLAGWEVFTRGGNALPHETVDALKECDAALFGAVSSPTRRVTGYSSPIVQLRKELDLYANVRPVASVAANPGGKPDVDLVVVRENTECLYVKQEQITPTENGREARAIRLITERASSRIGKMAFDIALGRPRKQVTIIHKSNVLSVTDGLFRETVRAVPALPEINGAYDNVKIEEQIVDSAVYRLFREPEIYDVMVAPNLYGDILSDAAAALVGSLGLVPSVNAGDSFVMGEPVHGSAPDIEGKGIANPLAAIRSAALMLRFQGHTVGADRIDRAVEQVIREGEVLTPDLGGTSKTQEVLDAVLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUY7</accession>
    <name>A0A2G8SUY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUY7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUY7"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000006">
        <property type="entry name" value="Chromosome 7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="271" mass="30618" checksum="9E001A350AC9617E" modified="2018-01-31" version="1">MATKHWLMKAEPNSRIVKGKDVKFSVDDFEAAKTTPWEGVRNAEARNLMKEMKVGDKVLFYHSNCKNPGIAAFAEVSKEAYPDYTAWDASHPYYDAKTDKDNPKWYMVEVAFGSRVQHFVPLALLRNIASSSELPEEVAYIGEDGAKAIKAMALVTRGRLSVQRVEEETWEVIEQLAEKGGWEEVGTGKPKTKAKPKVNTKVTSSRRKRSRSKKAEDSEGAEDAEEDEVEVEADEEVEENRPRQRKRKAATIEDEPGGESSKPRRSTRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV96</accession>
    <name>A0A2G8SV96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyoxal oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV96"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV96"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010916">
        <property type="entry name" value="TonB_box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00430">
        <property type="entry name" value="TONB_DEPENDENT_REC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013701463" description="Glyoxal oxidase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="68"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="448"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="59850" checksum="5118180F4FC8DEA5" modified="2018-01-31" version="1">MKRSILSLLPFLATLTHTASPPALPAWQFNLKAESSGVVAVESVVVSPNFAIFFNRASNDPLQINGHSAWGALFNLKTAEVTALDVATNSFCAGGAFLSNGTMASIGGDELGFPGNPAIKPGNQAIRLFAPCASPTGDGCTVFEDPNLILLEKRWYPSAIRIFDGSLIIVGGMHVESTFNNIDPENSIEFFPRKEQTVRPSPFLVRSLPANLFPRLFALPDGKVFMIANDQSIIYDVETGTETPLPDIPNGVRITNPIDGSAILLPLSPPDFTPEVLVCGGSDIDDRIPAEQLSSQFPASSQCSRITLTPEGITKGWEVDHMLSNRTLHELVHLPNGQILVANGAATGFAGIASVRDPVGNSNADHAVLVPELYTPSAELGGRFSNAGMPSAEIARVYHSSITLTPQGNFLIAGSNPNRESNITGPGVKFPSEFRVQTLDPPYMFVERPKILSTPERLAFDSEVTVPIFLPDFLSHDDAKIQVSLMDLGFSTHGFHAGARLVFMDATISKDKKSLTFVTPPNGRVYPPGPATVFLTVDDVSSEGAWVMMGSGNAPPTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVB9</accession>
    <name>A0A2G8SVB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_01409</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVB9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SVB9"/>
    <dbReference type="OrthoDB" id="21072at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039113">
        <property type="entry name" value="ATG29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040666">
        <property type="entry name" value="Atg29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039362">
        <property type="entry name" value="ATG29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40012:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18388">
        <property type="entry name" value="ATG29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Atg29 N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL37715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="615" mass="64429" checksum="3BFA51BB103BD604" modified="2018-01-31" version="1">MPSPPAVRVIIRLPYNRPEDAPADPPRIEWNADKEHILWEVIAKSRAIEGAGTDWKGLAQHLQVPLPYLLYRAQVRYEEDLRGLQGLNGLGLGTLALGIRTAAAPAFPSDPSASRANGPVPGLGEYLSRPSSVASQEPTRPLLAHRESGPANAPYGSLASPTGRDGTASTSGTGTGTSTLRPHIGVRARLSSLGHAHGRALAQQRVPANNNNNNGAGAYPHALANGTGTGTGAGTGTGTQLPTKKASSSTITLQGPKRVRSPALHLQPLSPAGSSSDGDGDGASGEEGEGDSSSEDDDESDEEARRADEAERQEALAQKLRDLERLMTKDALGLVADPVAARANGNGSAEGGWKQRGRVPPSGMGASLSSSGVGREQERERAREPRNQSLSSASVDSPQGSIPSIPSPQAQSQQYAYTYQYQYPAASPGAQSVHSNGHGHGHQRHHSQGYGYGAHQNQTQSAHSSMYRNSRNPQRSASQSQSLSSHSLSQSRSNSNSHSHSDPQSPAGMTSPMPIGRHLATPDKTSSPPALSPGSARGQTVQVHGRAIQIHRDLVAGTPSGSEASSFSDISDASLSQSALESALMSNMSNMSNVRSAGSRMSYRNRLPSKRSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM28</accession>
    <name>A0A2G8RM28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Plasmid pRiA4b Orf3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM28"/>
    <dbReference type="OrthoDB" id="2940229at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012912">
        <property type="entry name" value="Plasmid_pRiA4b_Orf3-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07929">
        <property type="entry name" value="PRiA4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plasmid pRiA4b Orf3-like" evidence="2">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="395" mass="45376" checksum="E6FF7E9C16B993EE" modified="2018-01-31" version="1">MSSTHAVLNDNDINVPQLPAVQSNTALQGSSKRPLEHAGQASGSAEPPAPKRPRPRWILTPTPEPEPEPSLIMPPPSENLIQLRFQLCRFKGVYRTVRVPLSFTFAHLYRLILLLFGWSGRHLHQAEVLTNVIKYASPGRTGEVKKHRYWKTPPEPNCREERDEWRDWYFKYGMFYREPAMRVVKKVRYDEWEIGPRRQDEPVNPNNPLEALWDELVVPKKRDEDVRLGDLWAPRNRDNMTGGVCKNVEIAIKFEYDLGASWEVHVTVEADKDGGYMWEYSPPTNKPVVVMAKGGAPVEDARSSHGELEANKKNVPSMLFLPDIFERYLKGEVGSVARKTEHAVFDVEEEQARRQSAAEEKERRRQERQQRQADASDDDGEEYSSGEDEDSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM92</accession>
    <name>A0A2G8RM92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM92"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="115" mass="12485" checksum="94E7914854AEF243" modified="2018-01-31" version="1">MKTKMGRGEPRAPSEDKELQEHLDVITEGSPRGLGRRRRARGTERVEATMRWAYEETSMWLRGGLGVPGGRAAGGNSSSARGGPPVCMNAYQKGKAVEPQLVLDNLCSWNMASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMA4</accession>
    <name>A0A2G8RMA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_15322</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMA4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMA4"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="139"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL22631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="199" mass="22311" checksum="868F27F7A94B963C" modified="2018-01-31" version="1">MKVYSLAIVLAPPNKSATVLSSASDLSSFSFYQRGSVAEFMSFFTKTVAERTPQGQRQSIQENVYTAHTYNRGGAEQLAAVMIADQEYPVRPAFSLLTKLLDDFIAKVPQASFSTPAAISFPEVSTYLQKYQDPRQADAIMKVQQELDETKIILHKTIESVLQRGEKINDLVDRSNELSMQSKMFYKTAKKQNSCCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMP1</accession>
    <name>A0A2G8RMP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_15482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMP1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMP1"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013688171" evidence="6">
        <location>
            <begin position="19"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="108"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="417" mass="43723" checksum="DB3BB31AEB036361" modified="2018-01-31" version="1">MFCKATLFTVALALIASATPITPGGVRIPLQKRGNLQNADGTFNHEAAIREIVKLKNKHRQNLINLEKNVGRQAFSKGAEIKPLATLPNSFQKRGSVELTDQENDLLWTGKVSIGKPAQSFTIDFDTGSSDLWVPASSCSTCGSHSKYDPSSSSGSKKESGSFSISYGDGSTASGTPYTDTVTVGGVTVTGQYLAAVTDESAEFQKDPSDGLLGLAFPAISNLKHDPFFFTAVSQKTAKEGAFAFKLGSSGSELFIGGTNDGLYSGKVEYHKVASSNGFWQIGGASASVGGKSVADGFETIIDSGSTIITAPTGAAQTFWAGVDGAQEYDQQQGLYQYPCKSAPKVSFSWGGNNWEISSDNLSLGETSSGSGQCVGAIAGGDLGLGDNVWLLGDSFMKNVYTVFSVDQNSVGFAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNB6</accession>
    <name>A0A2G8RNB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNB6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNB6"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="398" mass="43142" checksum="12515B4E87B7AC39" modified="2018-01-31" version="1">MNPCSHSSAYTSTDAYSYASSVANGSLTISYLQHSPNFYEDPSSAAEGWSGEDVGLAEWLDADRALFEALVTVEVTNTSPPSGSRTLVPMQSPPSYSPGLSSLYYPTEAPCPHAQSLGGSQSHPSATVMSTVLTASEHTQREMTASDTAFDVIRDATRLPRIVLFISLSFPRASLQASSIDIAPQRRHAAVHTSHPHISFAFKQRPPESATPSISPNLVYPSAHCGHNLEDDHSTDVSPHSSRASRRTSPSAPYPSPSPSPSPRTPSTIIASQRRNVAAHTRAAPAASNTWQCPYCPYVQRNRRSPDLKRHVKTHTRDAEAADWVCCGVPVLSAIELGVPATILREAQVFEFDGVLMVGGCRKAFSRRDALKRHLQRERGRCFGDASSLYQPGNRDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNM2</accession>
    <name>A0A2G8RNM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_14418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNM2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNM2"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="45"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL23109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="150" mass="15678" checksum="D67E0C7985A95A1F" modified="2018-01-31" version="1">MAPKPSSTAGKAPASTASKAPAKTTSEGSAKGAKKTAKAASGAAGEGEKKKRKKSRKETYSSYIYKVLKQVHPDTGISNKAMAILNSFVNDIFERIATEASKLASYSKKSTISSREIQTAVRLILPGELAKHAISEGTKSVTKFSSAGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNN4</accession>
    <name>A0A2G8RNN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNN4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="131" mass="13734" checksum="9BDF801EF7C1A56B" modified="2018-01-31" version="1">MTPAVAGSIASPPNVNVIPHATLTARKGPFSRGSAQFDFGRSSLTLLDCVDTPSFTAGSHRTPDCSAPNARAASLYRPIVSTNASVSSRPFSESFAASSSMLSAQIFSTTSSAYSSFRSQDTTVLSYTWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP79</accession>
    <name>A0A2G8RP79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP79"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP79"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="3">
        <location>
            <begin position="14"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="245" mass="26784" checksum="B5DC2F1A48F8B0DA" modified="2018-01-31" version="1">MICKSGLSGSKKGVRTGLDTEQAFEFANLKTTDDDELLSRLSNHTDVGAIEVGVVRVHAEGRPVSVTVDKFSGMGAVHERSKKAGAHSVGLGEGSLVQPWTQMWVHDPIDPLEGKVATFIFRYRPRDLLQAQGIMPLDRPQSSEVDPSTVKRENKRPGTPQQRDAKRRRGGSASASGSRTQSAKKDLGVVEVLSDEEDYDALKSQLRKLQSKFDKAARKKFGDVKQEQDIVVGSNGDVIDLTLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPB5</accession>
    <name>A0A2G8RPB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPB5"/>
    <dbReference type="OrthoDB" id="2749722at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="11092" checksum="4A4011A65D13546E" modified="2018-01-31" version="1">MSGYLPLARDSVEDTNKDGEVVPSIDSEPWADEKSRQPRSTYTFAVYVALALVLVNVLVWAFAASKFKTIYDTIQDNLEVVDTRMLPRPDAGNGVKLSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQQ6</accession>
    <name>A0A2G8RQQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQQ6"/>
    <dbReference type="OrthoDB" id="2507795at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018822">
        <property type="entry name" value="UPF0646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10336">
        <property type="entry name" value="DUF2420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="801" mass="87416" checksum="EB87DFD8CC1641AE" modified="2018-01-31" version="1">MTSTMTEAFDTHMTDPGDIDISMYTGTAATDSWLPVEASMSDDAYAADAATFHYNQGAIEIEMGDDDEPITEYEMADEGQAYDGLEIQDIEVYDISQVPSPLPADDHDIIATTQSHVEDAEVMNIPSSEDPAPEPTLELHTTAPEVPVISEEVVVGDSIVPADLTDSSVVVNYDSTVYQPDPTSAAGSHLAEAVLAPLDDGVPQAELPSRTSGHFKLAEATRREDLSSGQTVESHSQPPEFAQHENHATQDLVGAEDHLHANLLDESAAAVGQDENDPHEISDGVYIDPPPAVLLSLPPSAEFGECCLFNLPPSSARQSPSSSAQPDTGDTPRLLLQERPTLYYEPLSAVFAALRQEEGIQRMHGFAEAELVLDAYDLQLSIPEDNIYTHEVTLHELNVIHDGSDLGGPLRLRLKVFAPRFVARYNMLRDQISRLNFAEDGERHPDVAPPEHYEPEYVEHDVHQADEGGEQGHYEDDTTQEPRFQFDEEHTGGVALEVVEAVTAANVARGQEEGETHKDTDDKRVERLPGDHVGSGGGVVTGVDPAFQAAQLEAAEEEVAEEDADADGEYDESETFDADEVHEHTTIEEGGDYTEHAEFPDDEDEFGEDLPEEVGGETKDAAYPHVGAVDDTPELPQDENDFEREVPVGVVGRHGEQQFDDTGLHTNPYTNAYAQSNSVEVPETGVEDPLRPTSETFTEEDVLNNLETDNVGHEETTILTEDAEDNGFGDNWDEADTLSSHENAHIEEHAEALSRKSSTTTLASGISKRAYEEVDLDDFDDGDDFFDTASSSPSAKRLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQX1</accession>
    <name>A0A2G8RQX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQX1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQX1"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013869947" description="FAD-binding domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="453" mass="48542" checksum="43149D39E3047A8B" modified="2018-01-31" version="1">MSLPQFAQVLIVGAGPAGLCLALALQKQGCPHIVIVDAALQGQNTSRAAAVHAATVEALETIGVADALVQEGLKFKKTVVWSSTHELETASFEPLSKYTKYNYILGVPQHVTEMILNQTAQDRGISVHRPFKVVSIKPSADGSNLTNVFFENGHVLRARTVVGADGARSTIRQLANVGWADPSGEVNTNKKEEVLANMIVADITVTNPPPFPRDSLNLALSANNVVLWVPLPGSSYAEMNVPQGEAVFRIATGIPQERGQPPPAPDTAYIQDLLDNWGPNKVLPLDTPRVEVTRTLWSSRFRTHSAVADSFFAHVPAEGGEGGGPIMLVGDAAHIHPPMGGQGMNLGIRDAIKLAPAVAEFVRAATSSPDTASEDLEKPLAEWAAERREKALTVIGLVKQIQGLMSMPNERQYALGFIPYNAAWIRDTLMGFAMKFESVKANGAYRVSGLGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSC8</accession>
    <name>A0A2G8RSC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_14170</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the activator 1 small subunits family. CTF18 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSC8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSC8"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053016">
        <property type="entry name" value="CTF18-RFC_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46765:SF1">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="265"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="755"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL24416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="849" mass="93480" checksum="4FE536C1A153FE16" modified="2018-01-31" version="1">MAALEFGLPSSLLLAGDPSDTPTESLIQAAIGDAFVPTGLLLEEPAVPQENDRGESSRVSGGEFGDAPLLFGEPTLPSQDTTSQFKSQDEDLPDVAELLKGYTAKVASLAPVPSSSRVISTKTFDGSSVHFTRKPPRAKATAALRRAGILPQAGQGQRTKTLLDAPIHKMLEDLSVSAAAKIVSEEAQPKKPAQLANTTNTLMWVDRYRPSRFTELLGDDRVHREVLSWVKEWDSCVFGKNKNRGRKRSREDANSENLDQWRRPQEKLLLLSGPPGLGKTTLAHVVSQHAGYNVFEINASDARSADVVDERIRPALESGSMIGSSKPNLVVIDEIDGATGGSDSSGGFVSRLIQLTYDRPYKKGRGGGGRKGEQQQHARPLLRPIICICNDLYASSLTKLRQHARIVRFARPHDTHVVRRLREICEREGLRADARALATLVGVAQGDFRGCLNTLQMLKARMDAGSGTGGMVTEGAVRSATRGMKEAEVGMMTVLGDLFAPLSKRRAKEMGVREDEPRFVTRLSVAVESCDSLDKIAIGCFEHYAHLHRHDASFDRYLKGTEWLCRWDVLMGSMRAEREYALLPYMSYPLVAFYPLFQDRGAPKVERPKADWEHYMKLKTNEEIYKSLARCLRTAASRSAGDYRHLAHGALMQLELAPYLNRIISPPLRPVNSQVIRPAEKALLARLVGVMANLELRFVQERTEEGQLVYRLDPPIDVFVTYDGRRAADIAVSRYAVRHLVAAEIDAQVIARQAEGHEKSKGGKSAFFGGASKGNASTDDGRPVAKRQRQEEKLAEKAAVDFFGRPIVAKDKPESATGGPKVKPYRIAYKFNEGNSAAVRKPVKVSAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSX7</accession>
    <name>A0A2G8RSX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_12501</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSX7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSX7"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL24617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="516" mass="58487" checksum="75D65C882BA3F2C9" modified="2018-01-31" version="1">MLEALVIVGLASTLSFLLWWLHRPRGMPPGPPRSFWGDNTLDIPRVKPWETFTAWNRKYGPVVSFYLGRKPVIVLGTAQAAWDLLDKRADIYSARPRSIVALSHTGVWRMAQLMQASLSATASAQYRSLQSLESKLMLRRLLNLKDDFAYKSEITLFQMSVIFRLAYGRRVKSLQDEVVLAKIKAGSYFGEPAYKADDMSCVVNRVHRRVPGKYLVESWPILLWLPKCLQWFRRDIDKHREMDVALYMSLMHQVRRKMADGTAQPSMATIALGKQEEFGLTELETAYTLSGPWDAGVVTTLVTIDNFLLAMLHHQDAYLKLRDELDEVVGPNRLPEYSDMESLPYLMAALKEVTRWRAAAPTGFPHAVTQDDVYQGHFIPKGATVYGNIHAITQDPEMFPEPDVFRPERFLDATNAKLANFTIPFGFGRRICPGMHVANQSIYIAVARILWAFDIAPAQDEHGNSILPSTTAYTTRLVTGPEPFPVVLKVRGKSVEELIVLESERAEAEAMRWDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTA1</accession>
    <name>A0A2G8RTA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTA1"/>
    <dbReference type="OrthoDB" id="5987198at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="370" mass="42905" checksum="888FD14B21A5B03A" modified="2018-01-31" version="1">MSAPSARLPRYAYVSPESAARHAKDTEEGLYNLLPGEVFWKNRCLFLHDRGYELRPRYRPDWKPSWIGTNRTPLFCEDSIMLNIPTVIDASRLSDDFRVAIKYTNSDTKELRIARYLTDQHSPRNHCIPVIEIVADPYEPRMSLMVMPYLRPFNDPEFGTINEVMDFIRQSLEGLAFLHECRIAHRDIAAANVMMDGRTLYLEGHHPVRIESLPDGVLDAHPVARSNSQVRYFFIDFGLSELFEEGDSTLVTGCTGRDKEIPELSNEVPYDAYRADVFALGNLYYKEFLSKYYGLDLIRPLVDMMKWKNPAQRPTADAAFHIFESIYHHTDETLLRWRLRSREESAPERVVYDTVAVAREGIYQLRKLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTX9</accession>
    <name>A0A2G8RTX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_12821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTX9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTX9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF218">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013775626" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="51"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="11">
        <location>
            <begin position="487"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="639"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL24934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="72038" checksum="B2B10A25655238ED" modified="2018-01-31" version="1">MRSFSLLLLTASLSQCASAHSGAHHDFHADHAHRDLKKRNIVYNGQIASSYDFVVVGGGTAGLAIASRLSEDSNTTVLVLEAGDSGDAIADRINVPLNAYFDGLVGSSYDWQYKTVSQAQAGARPYSWPRGKVLGGSSAMNGMYHVRPSKVEVDAWASLVDGGADKWSWDKMFAAMKASETFTAPSSDIQSEGGIQYVASSRGTDGPIHVSYPGYMLPVVGNWTTTLANVGVDVSQDAYAGESWGAYVASSSINPNNWTRSYARSGYIDPLPPRSNLAILPNATAARIIFDTSNASNLTATGVEWTSASGAAKQTVSVKKEVIVAAGVVGSPQLLQLSGVGPSDVLKAAGVSVLSNLPGVGQHLQDHLSTAVTWTTKIDTTGSLHANSANANNAAFMSLVNEATAYVNITDLLGDFSSTFKQQISDAASTSLSTLCPACDDTVKKGYSAIYNTTLNTLLASPIGQAEILFSLVSSGSISIQAALQHPFSQGRLYITADDPFTPPTIDPQYLSHSADLTVLREGLKLARKIGQTAPLSSVMGDETAPGSSVQSDDDWDNWLVGVIGTEYHPSSTCAMLPLESGGVVDANLKVYGLGNVRVADASVFPISFSCHLQAPTYGLAEQAARIIRATYNGVGWPSASGQNSASSSNSSTSASPSSTTGTSSGKNGAEALSHSGSLVLLAAGALAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUH7</accession>
    <name>A0A2G8RUH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor IIIC putative zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUH7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUH7"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="3">
        <location>
            <begin position="667"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="86649" checksum="12CD586BC69A38C9" modified="2018-01-31" version="1">MAELPLPTVLSLPAVSVSSSVRCLQFSQDGQLVLLTKYAVYILTPDTGVNVELSSVIKQTLDSKPSARSSAPPLGWLRTMVEFDRSLAHQWHAEYWGAVSLGSLDPSLQAAALSPSNLTADAGCVLALLSSNLELTIWGASKNSLTGAWIKLQDVTSSLKLASVASPPRSAFKETLRLQSTCLDWSSQPSWNLTPAPRIDASLLAVGDRAGCVTLLRYVRSDRYVAPVEEVQVSDRWVTHLAWSPWLLTQDGTCEAMLACGISDGSVNILVVRQTLTSKPGTTRFIPTHDLGLSVQAHHEIACDSDGRAITGMAWANTTGRTPILIFHKAAVVLLWSTASNASAWSGSRALLLPTQKRSVGSSALSPSSGVSYIPDRDICVLSLSDGSFHVIHNLSANPSLDPPLSEVISSQTLSAVSRAFFSRAEPEKVTLKDVDRINGMTTYDGRATFVWTYEAYRPTDFSYKHDAKHISTLIVAQLWHETTIDQQVVADLAESVGRAANSGETPISTLRSIFLHLRDPVRLSRIHSDVLNALHQGQPTGASADINVPSYAGEWTADVSRELRESLTTHLFGWDSIQSQRKRYAVALFCQSRAQAPDVQQKFADAARLFLTHIRAHVQLTLLRHISALGAPPALAKEAEILLAHFSRSAPHPEPINASATPTASVDSLDEPCPACGASVPLVPSETENAMCTNGHVWARCCITSFLLSTPMVRTCVGCSRKALLAPPSAPTGAVTTAVADPPRGNGSGDGDKDGDRHGHRDAGPPAVAGGTLSGLPGSARDSRVVRDLLDATRRCPFCGNNFVMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUI5</accession>
    <name>A0A2G8RUI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUI5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUI5"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="27210" checksum="01ABEFF15C3F5483" modified="2018-01-31" version="1">MSFCADCFKGVRHEGTPEGTTLTIAGIETYVATPTGEYPKDKVVLFLCDAFGLKLENNKLLADDFARNGFKVVMPDLFDNDPAPTDAFNPGVNFNIMEWFGKHPFTRGNEIVRAVIDALKADGVTKFGSLGYCYGGRLCFDLAFTGDVHVVATAHPSGLQAPADLTKYLETSKAPLLINSCETDQMFPAEAQKAADDILGDGKFAPGYERTYWPGCVHGFAVRGDLSKPEVKAGKEGAFKASVEWLQKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV19</accession>
    <name>A0A2G8RV19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV19"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF3">
        <property type="entry name" value="VELVET COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="27"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="438" mass="47029" checksum="494FA0FDA3916985" modified="2018-01-31" version="1">MQTDNVYRATAPTVGGWHSFESGPLAGRAVRVSLQELQKADHGRKYGRKDKRPLDPPPVVQVKCYQIARQGSAEQGGREFDTYDEFLTFGFLCHVDLFAEVSDPAPAPAARQQYPFQPSIPNPMNGNQWSPPVARNSFPGAESSGMAYGPAVPSMPYDVRAAPRADYARTVDPSTNRGHDPWSMRPKPYMGPSTSSPFGHHRYSDENKCTELLSGETVVPCSLVEYGGRKAAMFAFPDLAVKKEGRFVLRYRAFNIQSKTRDDGVVSILAECFGGPFEVYSTKSFPGLQASTELTRRLSLSGVRLNSRQKERRGVKRSSRGGGDSDTGSSPPRSAPHAALTARVSSTSLRKPFGLPAGPGGPVPYAAGFPSPEFPYAHHAAASGSAGLQGPMAGPSRTRSPVSLLAWSRLGGDAGDMRGGGDSCSTGTEEDGSTHSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVF1</accession>
    <name>A0A2G8RVF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13381</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVF1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVF1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="193"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="731" mass="78401" checksum="44CB9B1C4B32F841" modified="2018-01-31" version="1">MASVRASSLPTAIGCSQTPGAQRGRTAAKGSSSAPRSPNGHPDARLDSEVVMVLVPILTMDSDGFYDGRTVSPVPSKMKLRRELYSVSISPSKSDSEAGSDPPQPVFHDVTVLTFSFPPILWRQASVSLLHGMPSSRPLTSALHKKEASSCWLTPSTSNLTVRFEMSASKLANLLPLALWFSRVTTVWGGGLPSVQLDQATVYGITNGSVTSYLNIPFAEPPVGELRLRLPKPIDTYNGTIDATQIGPQCIQQPLPLRPDMPAEMLSDMIAAMSVSPTPPREESEDCLNLNVVVPAGTAPDAKLPVVAFIYGGGFTFGSNTQFPGEVMVQRSVETGQPILFVAMNYRLNAFGFLGGQEVKDAGIGNIGLYDQREGLRWINKHIAAFGGDPDKVTIWGPSAGGFSVGAQLVTNGGDNEGLFRAAVMSCGTLLPTGDTSNVQPFFDGMVAHAGCATAEDKVECLRGLPVEDFTAATGSVSSFFGDKAVPPWFARADGGFLEEPVRNAVLAGKFANVPFIAGDSLDEGTFFATGAWNITYARLVTPVMPVPPSTDDEFLDFLRGFFFPGASSAEVAPILALYPNDPAQGSPFGTGDANQLAPMYKRMAAFEGDFLFQSTRRSLLTLRSGKQPAWTYMVERNRFQGVGYPHGNDMLSFAVDEDFMDYLIRFVATLDPNGVPGTASNETVRWPQYDSAARRTLFVLDGEKPLVVGPDEVREKAMEAVAALSLKYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWD6</accession>
    <name>A0A2G8RWD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWD6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWD6"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013681427" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="10"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="411" mass="42770" checksum="E2DAC1909F1B2230" modified="2018-01-31" version="1">MSLAVPLAYALFSSAPALAAYNLAQEYSGSKFFDGWDWQDHVYDDTTHGHVFYLSEDKAMAKPNPIAYLNDAGNAIIKIDNTTSVDYNNKRNSVRIATHDYFPVGSLFVFDAVHLPYGCAVWPGFWTKGPNWPQDGEIDIMEQVNLAPANQMTLHTEAGCTQASGVQQLGKTVGTDCSAGVNSATGCSVAEAQANSFGAGFAENGGGVWATQFDATGVFIWFWSRKDVPASVSSATNSIDPSTFGTPSAAWPASSCDVGQFFNPQQLVLDITLCGDWAGQPNLYQSSCGGELGNTTVDMCYLYDVINLNQTALANAWFEISYIKVFTQNNASIEVPVSTSGSSVVLSAAANTGAASGTGSGAPTASSTSTSSGNGTSSNTGSGGNGALPSASAYVAALGAAVLAVSSWALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWI9</accession>
    <name>A0A2G8RWI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWI9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWI9"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="12106" checksum="3B84F95EEBABC7BA" modified="2018-01-31" version="1">MAAAPASLKHQMQKIAGRWAEDPFRPNVQLKTFLTSLADHPNLTPMAVRAARALENDEFKKMYALSDKILKPASMPHHYTRLIEAFEKSAQGIARPWWKIFFNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXI5</accession>
    <name>A0A2G8RXI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_11959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXI5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXI5"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="194"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="555"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="822"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="656"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="745"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL26204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112056" checksum="1BC85CBEE81C2004" modified="2018-01-31" version="1">MTDPPKPPATQRKSRVLAALDNPDFLYNTASSPLPPVSGTPLPPGSLDHLQTPVKQRLVTPAPSFNYGASFLGLVGPSQLKRSTPDDGFDEDSDDMGSSPAPQAPRGSQLAAGQGFNLNYDKDGAVRAIDRGGPDQEMKMAEFVSQGIDNAGNGLTTQKAMEKLGLQDLRDYLPGMEVRLLPHQVIGVSWMVDQERNSPHKGGILADDMGLGKTVQMIATMVFNQPTEEDDHRSILIVVPAALLLQWKEELETKANGIWDVHIQHGKDKIKNPKRLAEKDIVITTYHTLNLDFSIPSDLDSDEELNWLRDNGGPISQIKWFRVVLDEAQFIRNRSTRCSKAVAMIRSKYRWCLTGTPITNTLADIYGYLRFGRFRPFNDWSDFNGFIAKVQLEDAPLAGQRAQSVLMPILLRRTKDAQIDGEPILKLQPKHIDMVTIEFSQDERDLYDAFEKRARIQVNRFIKNNTLLKNHQYVLVLILRLRQICAHPHLVLAETDGFDDPTALLGSESDKELARAARLMGSKWVNTLKQRFMDRAKALEMAWENDDDDAEDSHCPRCGDMFLENNGRILSCGHEICEECVQTLATSDIEHNGIFGNNDEKENLRIEKEFETAAAKGLRPCPTCKKMQDLRPNSVFLARAFMPSEEEVRAAVRAARQIKKRRDSTPPPVKKPKLELISISDIEESSSSDEDSDDSMPDISTMLKSSPHGDKSKGLNKKAPAKKVPAKKGKAAGGKGKDKVKKADSDEDMESSDSDSESDAPKKGKGKATAKGRGRASAAKPANKQRAKSRDSSEEPPKPNANLYETWKQGGSNVESSAKMLQMVSYLKEWESTGDKTIVFSQWTSMLDLCEQIFFRHGIRSLRYDGGMSREAREQCLGQFRQIGGPKVILVSIKCGGVGLNLVSANRVINLDLSWNYAAESQAYDRVHRLGQEKEVFVKRLVIRNTIEERMLALQETKLSLAGAALGEGGGGKLDKLSVKQIKALFGMTSIGNRERERNRQQSELPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXK0</accession>
    <name>A0A2G8RXK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXK0"/>
    <dbReference type="OrthoDB" id="2758611at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="369" mass="41343" checksum="D6105D9726DC02DB" modified="2018-01-31" version="1">MDSECRILRLQPELGAMFADAMDILSLSMWRLSCKANYHQVSSSFRRSLVKLLRPFLPSPHSFIDLTSKFNAVFGGEFALTFILRDPTYLPSRVDVYVGIFGFEGFCEAFLDDPVVRDVIDTHVYVTVSPVDALRLLVTRTLSVHTLGGKTISIHCSHTVSATAPVCRAACTALSNFVTSYSFGCSHPILTLNRRALLADLAFPHQPLFQHDVFTHMLKHRFSLAVSPAAWPEYRELRAVIRRDADSPSTLGGALGIVVDTEWDDSREITQACWRHLYVCPAQGRYFGDRGSLIGFFDPLNGDETYCEAHDVAPFGQMVLWRVSSTFECNDACDFDDILEEGVTSIPVLIKKDPHGEIRDVISDRYMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXW1</accession>
    <name>A0A2G8RXW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXW1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXW1"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013755412" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RlpA-like protein double-psi beta-barrel" evidence="3">
        <location>
            <begin position="68"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="128" mass="12821" checksum="42CBE3D60A999BDE" modified="2018-01-31" version="1">MRFAVAALAALSAASAAVATTAMTGGDATFYAPGLGSCGHFNTETDFIVAVDIATIQSFPGATANPNANPMCGRQMKVTSADGKSVTVTVADTCPGCAPGSVDLTPTAFQQLAPLSVGRLHGVSWTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY21</accession>
    <name>A0A2G8RY21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY21"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY21"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013869949" description="Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="255"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="583"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="74180" checksum="572329857248BA5D" modified="2018-01-31" version="1">MQILLATVLATLGAAAAVPYQEYILAPPSRIIRPTSVYLSRGSLSSEHALLDGQVSSGRSLTLDKFNSSVTYDFGKNVGGWINFNTTSSSGSVGFTFAESSIWVSSEWCDATLAAGVTLDTPLVFNITGAGQYSPPLEKERGAFRYITVINLGEDPLSINDLWVHFAAMPHWEEDALRSYTGWFHSNDEKLNRVWYAGAYTNQLVTIDPTRGNAIVQIPAGLNLSVPVSARDSLAAFTFTPDPDWTLNTTITKGTSVLVDGGKRDRLVWSGDMAISLPSIAVTTYDLISAQNALDSLFNLQYTSGQFPYAGFPTNLGHVTSFTYHLYALIGIGTVYQWSGDRAYVAGKWARWKTGMEWGVGQIDATGLANVSAADALDWARQGMGGHNIAANALLFRTLTVGAELARTQGDSAIGERWTRLAARIQAAAIPLLWQPDVGLFRDNETTTLAPQDGNAWAVKSGLVTDPTQIAQISEALQARWGAYGAPAPEAPDAVSPFISGFELETHFTANRTAAALALIRSMWADFMLGDPRMTNSTFIEGYSTSGALHYDASYPAPADPRLSLVHGWSTGPTISLTTYVGGIQLLSPAGATWAIVPQIGDLADVDAGFSTSLGRFSSKWSTNGTVFHLEISTPKGTTGSVGVPLPGNFKSAMLSGMNREGEVVRVDACGRYWINGVDGGDHEFVVVGLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYE1</accession>
    <name>A0A2G8RYE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYE1"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="362" mass="38083" checksum="74DCB516547517A4" modified="2018-01-31" version="1">MAPTTQKALIIPAETQPHKLVTDWPVPKPGPTQVLVKLVSAAINPVDAYIPLFGGLGLVSTWPFVNGIDGAGIVEEVGAEVTSVAKGDKVFFMGGFDNRCATFQEYAVQAANRVAKIPDNITFDQAATFSLCLATVVTGIWANDGPNSVRLTPPWETNGTTKYAGQAALIFGGGTSVGQFAIQCARMQGFSPIITTASPKHTAFLQSLGATHVVDRALSPAEITAALPALTGGKPIQYVHDSFGRDRDAQRLGFTALAPGGAFVTVNPRNPEFIADLEVESEKKGEGKRVARAFGSYEIPGNGKLGDEMFGRLTGWLEAGVLVPNRVEVLPNGLAGIDAGCEKVVKGEVSGMKLVVHISETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S064</accession>
    <name>A0A2G8S064_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S064"/>
    <dbReference type="STRING" id="1077348.A0A2G8S064"/>
    <dbReference type="OrthoDB" id="3262409at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="174"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="351" mass="38728" checksum="948AB076B5EFF574" modified="2018-01-31" version="1">MSDGSSPSPVPEETILEIGPILVGALLSWMLLGISTVQLYIYHVSFPNDRRLIQAAVYVIYLLDIFQSIVAASQAWQFLVAGWGRHINLEFPGWTFTALPIVSSLVSLGVQTFYAWRVWQLGRWRVVPCIIILTALISAGAACAVAIRFAFTRSIASLHATSAFIPAILWLGAAAVADILIMSSMLYLLYAVKQRTRPFERSEFVVNRLIKLTVETGSACAVSALVQLGLFSGMPRTNVHLVLALVLSKVYSNALMTSLNARCPKSFSPETTSRTRSVGFMSRRSQSISRRQLASPSLPPVAIHITQEVASDRDQTDDKDMQHWEIEMDDVPSPMEQTTRGRMQSAKTPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0D1</accession>
    <name>A0A2G8S0D1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0D1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0D1"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF42">
        <property type="entry name" value="ZINC FINGER, CCHC-TYPE, RETROTRANSPOSON GAG DOMAIN, ASPARTIC PEPTIDASE DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="31625" checksum="B3BAD72701872CBB" modified="2018-01-31" version="1">MSNAGTTPAPLQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFLPSFPETILWITLLNKLTEGAAEWAGPHIVTLASGTQPWADFAAFEMAFKAHFCAADDKEAAIAELVKLCKRQHKIGTMQDYMVKFNAIAARTSFSAKDKRERYRTGLPYKIKDILATSGHDTSSITKIQAVALTMDQNLLVREEERPKQFSGGWRKKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSGETTDLAALRAELKEIKERLSAVSVNETKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0K1</accession>
    <name>A0A2G8S0K1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10447</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0K1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0K1"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="29"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="203" mass="21405" checksum="20602DA3132E2905" modified="2018-01-31" version="1">MSQSTSASASGQQSTSGSGSSSSSAIPQTAPAGGLTITKPPQTATSFFKIAPSNTITFAWNFTDVLSTPTHLTVSAIGENGNTYPVGPTDGIIDGTATSVTWDLWSYQQAHSTLPLAPGSYVLHIWDDRGPGAAREPGLLQENSALKFALYTPQSYTPLESWVCSTCSGAWTDFATHPAFVSLTVTFVVMFLSGYSLIRQALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0T5</accession>
    <name>A0A2G8S0T5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0T5"/>
    <dbReference type="OrthoDB" id="10420657at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.198.10">
        <property type="entry name" value="Delta-endotoxin CytB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035918">
        <property type="entry name" value="CytB_endotoxin-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="153" mass="16463" checksum="2036AD2CE5354D8E" modified="2018-01-31" version="1">MSSPSAKSPKFDLIVDIPESLLPTFTNVATFADTHVKKQPVGSQVANPGKPATAHFIWSDIRTAVTTRPGTDIAFDRLQSTTIRATEDASEPAADLAAKVTAFVADSFPALAREQLSERVEVAFAYPSEDGIPQRGPARPLLRARHHGQVSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S166</accession>
    <name>A0A2G8S166_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_10663</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S166"/>
    <dbReference type="STRING" id="1077348.A0A2G8S166"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="87"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL27512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="609" mass="65567" checksum="68ECCA2BB7C8FB59" modified="2018-01-31" version="1">MASVLPSPMLGAFEQPVIHPPALSMTPDDETTMSEAPDPSNLSTRSSMDMGSEAEKATSAPVDDAEKQELRTVEFEKPLSNREIQLVFFALSVAAFLGSLDQTIISTAMPTIASQYNALPQQSWISLAYLLTSTVFQPIFGRGTDLYGSRLMLFLSIAFFDVGSLFCAVATDFIWFCSGRAIAGIGAAGLLVVCMIIISQMVPLRDRGKFVGAMYARTAIATVLGPVLGGIFTRFNWRWCFWINLILSGPAVAILLLFIKKIPNKKRPGVSFKDVDFGGIILIAVCVVALCLALSWGGTTFAWNSPVIITLLVVGSVLIPVYILYEMYVPRFPVIPLDMFRIRNVVASTGNYFFSSVSMYGLSAYIPSYYQLVRGDNQLVSGLEILPYVGTIVIFSTVVGYLMSWTGRTRPWMWAGGVVNTIANGLLIMLDGTLPRAVEYVFLALSGAGVGFIAQTNTVSAQSKVAKELLASVTTMTMWSKSLGGIVGIAMQGSIISNVFQKNMFADPAAAPYVDQLKALSDLRSLPPDIQELASRSYGKAFSTMMIATTPFVAVGLLFSLTAEPADLDRKSGAEKPEEDEVAPKAGDTGSQTGNGDLAIVSEKPADAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S204</accession>
    <name>A0A2G8S204_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S204"/>
    <dbReference type="STRING" id="1077348.A0A2G8S204"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="POSSIBLE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17981" checksum="552BCB2866704ECB" modified="2018-01-31" version="1">MSDGPQTDYSRPSALPTAKLLQRQSQPTIDQNSNEYLDAIEEEWNKRVDVEIETLVDGMADIVGLAAIGDKDKFRIAQEAFQAQCRAESMIRAANSLMSTIHSMKLLLLLSDESQIAKRRDAELRGVQAEKADAQKRVAALLDELLLSSKGDRARDESMDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S251</accession>
    <name>A0A2G8S251_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S251"/>
    <dbReference type="OrthoDB" id="2734540at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="53175" checksum="639A0FA82776082A" modified="2018-01-31" version="1">MFVPETPLDALNWDILLYMVTFLSRPDVSSLMKTSHEFYELGLRELFRDPVELRANNVQSLHKCLHIGKSNPRSHYLRDVTMSCTLSHLPPVSRESNVSMEQLLCDILQNASRLRKLRFDWGAASLSGSFSVVMPTLHCLEELYMPLVSQELWDSIKGLRAPIRKLAVHFGPTNHLPFLTADPVSLLEPFQSTLEELDLAVVQCEDMSVVYPAVQKLSLADCYYGRTRGGIDIGPVMCAFPNVVDFSLSAAKAQPALSHWKEGRSCDHADLIERCRTANTQWQREHPHAAAGSGWAALESVTAGHVVDLYMLGLRRAVPRVEIRAFSKGTLWMFRHVVADTRPSHLAISLFAREDVLDCLPRLVPDAESADALRHLTLVLQCDDADIPVERIIAGVTGMLARPRLRVERLSLCMRRWDTVGPYRLSPRALRALDAALAAVWDGQAGAVAARLLDGIPALRELTLTVAEHEGRWART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2B3</accession>
    <name>A0A2G8S2B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_09940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2B3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2B3"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="233"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="318" mass="34615" checksum="5CE611DFD3AAE331" modified="2018-01-31" version="1">MSSGPSVAVIGGTGFVGLNISDAFLTDFRTSFSRVRILTRDAGTPKAQGLAYKGAELFQVDEDDVHSSLDAAFADIDVIVNTLPTTVSDRLNHGVLRAVARSGAKVYFLSEFMAYAHPLGALVLAAAVMLRHGLTASGVLTTSTLSARSDHRHLSSPGFGFEPAEWQRRRALAREVRRSFRGKVIALYTSLFFELAMAHPVLGFDIANNEFTAYGSPAQRVSFTSLRDIGRAVARRRAPRHPLHRPSRTRTRTRTCRRERECGGGGGAGRRAHRGRDGDVRGRARRRRARAGRRARAHPDSGLEGEEGDARDSGRPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2M9</accession>
    <name>A0A2G8S2M9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2M9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="103" mass="11127" checksum="1BC728500F26C00D" modified="2018-01-31" version="1">MRIICPDPDASPESGIGFVEIGRDRRGDGARNQGAEHGAGSAESSRSRNGSRVFNQGRDVDVGPRRRGFEGSQKTGRRDDRFRVGVDSKTTAGSCEREWSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2P8</accession>
    <name>A0A2G8S2P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000029">
        <property type="protein sequence ID" value="PIL28049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2P8"/>
    <dbReference type="OrthoDB" id="3214103at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="389" mass="41612" checksum="CFCDA2762E583FC6" modified="2018-01-31" version="1">MSVYALTTQRNGRIHRATVILCLTILALFSSTTVYTVTTILRYQADTIASFVYSSEAIWSYSTPIDSSGVPPELADYEGLFEARRLHACTSATTLAVNIVLGDAIVCWRACVVWQKDRSVTALCGIFLFATLVMGGADATGSCVLADSDSLHVQGVLFGGEHYGSAAYALSLATNLLATLLVACKAWQSRRRLGAYLAAKIGGSQVEKLLALLVESGVVYSVLLAVVLAYQVCEFRYISHDSYNPSTSATSSAAEEEYRFLSIFGVIVTGAFVPAIAIYPTVIIVLVALNRSHVERGLTRTQHLESLPTPHLALTVTGDTIATSRVHGHGRFEVPGNLKDAHSEEARSLTGCGVLEGDSEASRRHMSEEETAEGLGTSTVCGHPQAQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4F5</accession>
    <name>A0A2G8S4F5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4F5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4F5"/>
    <dbReference type="OrthoDB" id="2754356at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="133"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="518" mass="59007" checksum="D6952FD190D7C59B" modified="2018-01-31" version="1">MYQWYTYAEVCYAYLADVTAKEDAYAIVSTFRCSRWFSRGWTLQELIAPAHVEFLAKDWTPIGSKRSLGTLVSTITNIHYTALLRLEPLSEFSVAQRLSWASRRQTTRVEDRAYSLLGIFDINMPLLYGEGERAFRRLQEEIMRRIPDQSLFSWSWSDSYLSFHSLRGQVERGHDRFRYDPNLCGRANTDAHESLLAPSPDLFRHCGRIEAVPHHEVTRQLQLGLDVPTPSYDFTPHGIRTQLPMIPLSLYLGGIGTQAAQLHSLQIDLKTIHIPYPDRIDAPRVVAFRKTHERFHLILPKKTRRALCAQGYSPSLKGGDAARPTIQWLALLHRDKSHSVLIKFQHTLDSDGVTLSLEAYVRLAGPRGLHERPDLWELVSWTDSYPWAQVLDKRAVAVTADSRTLKVTLELHLVSPDHYVPHVEIPHVEIPHVEIPHVEIHDESDIVQPSSDWPRLLTSIGSQSESIGTSCERRTQTKEYWEKGERVEADHLETRGEGGGSTDGKGAGPSWWAVPCDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4I3</accession>
    <name>A0A2G8S4I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4I3"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="433" mass="44646" checksum="9E0815151A7F9C5C" modified="2018-01-31" version="1">MGRKPGSAQRPCWHPHSSPPRIRYAFLSVVLHAIIASWPVQRARAQADHGVLQLSSAFEAFECQNMSIAWQGGVPAYSLVVVSDHVEEFSGISGTSFQWLADAPVGTTVFVSLVDSTGAHTDSPVFNVTNGPGSSDACLPRASSTTIVSSSSSTISAMPSTSVRETPSVLSFGASTSHLPSGAVAAIVVEAAVLTLSVAGLLIIFFLDRKDRTREQSRAGPPVVDLLESPRPPSQNIFPYPGESRPESTTAASSSPPHPAAKELPLRTGTVRRGPSPTIQSAANAGARQSFTPSEATFVGVGVGAGISGSPAASIRGSPSSSVRFAQGTDEKPPRKKRRTPLQQALLDVPPGTGAGAGAGMGTNPPSAFPAERMQSVPGDRGRASDASWPRDLDATGAGRGVVGGVSDASDLDGGGEQEKDGEPPLLTARFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S504</accession>
    <name>A0A2G8S504_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08902</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S504"/>
    <dbReference type="STRING" id="1077348.A0A2G8S504"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL28856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="361" mass="38301" checksum="05D18B8B8CE76C9F" modified="2018-01-31" version="1">MRAIQYYGPGDIRLEEIPEPIVGPGQVKIKVAWCGICGSDLHLYHGVMQGATPSATEPHPVTNETLPIGLGHEFSGTIVELGPGVDTTRLSVGDNVTIEPVITCMQPTCPACSTHGTRNLCARSAFIGVSGRGGGLSEYVVVDQMLAHVLPPGISLEVGAMMEPLAVGWHAVKKANFKAGERALILGAGPVAILLLEVLRVFKPGWVGVSGRSKKRCQLAEQHGASAVFNVATAGVDVVSETLKATDQLGADVVFDCGGNQATMDTATAAVRRGGTIMNLAVWSTKPVVDMTTLFFKEVALANSVIYADDHPEMLEALGQGRFGDLSSLITRRIPLEDFVEKGIKALINEKDQHVKILLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5X6</accession>
    <name>A0A2G8S5X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5X6"/>
    <dbReference type="OrthoDB" id="2691029at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="218"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="558" mass="63583" checksum="24430B1461FDCD40" modified="2018-01-31" version="1">MRIWHATKLVWPNVGYRKKALGWFGEAVWLPSMVKDLAFQDEVRAVLNKVAMVGSASPTCDGTLPSKSKSAVARWPGALYNGARKVILRTTVTPTFHKPTATLRCEPVQYRPMRLLDTHTGRFFEVHDPNSVEYAVLSHAWDSAGEQSYDDVWRIHASLYLKIEAIVFWRRKQIPRVLHGAIRSTESSHSNSSDDAGQGLRRAAMNIRSWNSYRFSPRISPNIRRACAVARAYGHRLLWIDLCCIDKTSSSELSEAIKSMWFRRGWTLQELIARRVLVFLSTEWQFLGTKSSLAEVIEEVTGISSAVLCHQMPLSEVPVAKRMSWAANCKTTRKEDQAYSYSLLGIFDISMSTLYGEGGRAFIRLQEETLKRVPDQSLFAWTLSDQIPPGPLSAFAEAYRRQLGVRAHREPPPVESQVVCVVGNRPAHAVAIFRQLAGYVISCSVDSFSGNKLALTRGDMRLSIQHRRRRPQDPNDPFVVVWVAPTAGGESTQWDEQPSITLDLRRIRNCKEFAFEAAVEGRRVVLHFTLSCMFVSFFWTWRFWTRRSRHPRRPVRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S653</accession>
    <name>A0A2G8S653_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S653"/>
    <dbReference type="STRING" id="1077348.A0A2G8S653"/>
    <dbReference type="OrthoDB" id="2758562at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="52912" checksum="4224E36F49CB33EE" modified="2018-01-31" version="1">MSAGPSRSRARVTRVELTADQLLGADLTPARPHKASKHAPKVITVEQLLGSSLTITPAARGGSGSSSATSPSSSRSASRTAARPNSVRSAAARSPSPPRVPVVVPHRERVTADEVLRTGVPLRTLQAAKQRARSGQALVLTAEQLLGSSAGSSRSHASSSSTRGLAAESSRRPNTAGEPTSAATPSTGSRSSRIVRPSTAGATTGGDGSASAARGRENRPRQARRSSSLGSTHTLPIYTKEPGESEVVIDRGTEDLEDEVPITVMTPVEEDGPNLANGLPNQIPSPPASPDITQSLSPAASPTASSLAPNSTQSRVINPIHVSPSAPISIPAAIGRTPRYPGVRLAPFPDEIPSYEAVMSMSTPDLHGFPANIPLPSSPPLSAIGSPRALSPSTGSPSTPASPISRPDSSSPSSPDGAESPRRRFGFMSLFHSHSHHSHSHGSGTRNRGRSVSGLPSQTPEGAAAEQLSASPPVECPRPRLRSSRSVLDMLSRSWSDNHMARSRSDRGLGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6V8</accession>
    <name>A0A2G8S6V8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6V8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6V8"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17934">
        <property type="entry name" value="DEXXQc_Upf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13604">
        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="6">
        <location>
            <begin position="577"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="894"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="925" mass="101735" checksum="9C2B31045F13E254" modified="2018-01-31" version="1">MTSFIQQNLISPDLDIAPRSISLRKLAAKDVNVITRHILDNDTAVLGVSLRTSAKDGRVDLVAFATGTHVFQVTLGQASPVGSNCKDDLSQLLASARCQLVAFDMARLALHLYKQFGVRVHGVDLSTLFSTSTAAPDTPADLVSTRLHPNINRHRIHALWHDEEERSICLRAWLAALIAESSEDAVLRALKVDTDHLPKPHLQCLADLMTNVALLEAEKPTQAENEFEGVVLDGDGQLVIQNARYNTRVRRSKQTTVVLETTHGRTITGHAVHAEGKRTGVAVHGGNFRGDIQSIRTVGREEPTLAERARDEFILRLLRGEVRSLVQSAFVRALWFPEGPPGKGRRTGSYQNQREGGDDGDEDADDEYGWSMSFAMLNAAQKEVVRAMWSDDEPLVVVHGPPGTGKTRTIAVALEEWGRCGEPTWVIAQSNVGVKNIARTLIKHDVDFKLIVSKEFYVEWHEHLYETIEQHLIRSDDLIVDPVAAERFIGGSAVILCTVSMLSNPGLDSCGMYHLVPVERLVVDEASQIDSFEFMHLFHKFRVLQKVCMFGDPKQLPPFGKETAPLMKTIFDFKHLKPSAYFLNTQYRMPLPLGEFISEEVYNSKLKSVRKITDTACVRFVDVRKGTEESMDPGWKNTEEVHAVVNIVKNYYKRLDFCIITPYDAQRNAIAQRLKQENLPWESVYNVDSFQGHEAPYVIVSTVRTTRPGFLCMLNRMNVMLTRCSAGMVLVTNRRFLADAGRDTLLGKLARRWNGPRDSDAWVDALALSLSDGRRASLPGAPATTAISSHPLGGGGLGASLAAASRSHSSTGLDGILGVVPARTAVLRAVARLAVPATATHVHIPLPRPSLSISNPVEPREPRYGYPTAVDGSEHLSAKLGAMRVVGRGARDGSDAFPALGGVSPKKKASAPMGRWRAGSDACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6Y8</accession>
    <name>A0A2G8S6Y8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6Y8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="109" mass="11697" checksum="3F9EE3D6251A9964" modified="2018-01-31" version="1">MHKEEPPALWGCVGDRTNKYWGQGGRRQAFNLLIVAALPPEVAGLDSHLKTDGDGTSRLGSSCACKFLVGLVGGAAHVSLICLSGYISTRRKIEACPCTRIVSVFKHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7A7</accession>
    <name>A0A2G8S7A7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">sterol 3beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_08297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S7A7"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="368"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="893"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1411"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="535"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="893"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1427"/>
            <end position="1437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL29660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1446" mass="159347" checksum="76E2D867988A6250" modified="2018-01-31" version="1">MAQDGQPDSPSTTPMSSPTISASPPTNHSSTSAESASDNKGNVVKCIVEKTSDRLGKSKSLLSQSQPALPQSSHKRIFSLTRGQGKERQTPTEDQPISHSQQLVPSSPPHSPWKHRRFLGAPGDDESPFITPTSPPLGPSRPESLIFRGFRSMHAGTQTFIQALQAVPWVEDQQNDEDHVDHDATPGESESDDDDKIVNRLTSSIHAIYRPLARFRRGELSASSHRAARSPGLPSLSDNDETPQSEDKSTSDEDTEGDFEPHRAHLITDPNHSGRISPEAIPDLDASMPDVSSGTRGIPRSGSMATVRQNRRAQLAEKLRDVFELSNINEVVAEMPCWLLRSVLLQGYMYLTDAYICFFAHLPSREDQVLKSGSLFKKAQRTKRWIRHWFILKNDVLSWYQSASDPYFPHGVVDLRYAISCEPLNDKDIRLRTNQKSIRLSADSVPNRDEWVKAIRRVMLKAQNMGDSIKIAIPYPTVVDVEMSSAMDFSETIEIKVQDKTSDLAVDSYFFAYFQDLPRALEQIRDAVRTYRGMPSSQCSPTVVDTTSGRSSAMRSPTSPPTEHAAKPLPSFKLTSLLRPLQETLPLSRSASTAGVTGTSNEEFTHIVKKSGSSFVPVVTTNETTSPTEGGPGSLRTSTSSLTPTITSAIHDHTYPPSTTASLVDVGASMALGSAKDPSGSGWSVGIPSMPSIPGWLRAPSRSLFGAASTSTVGSGSPEKPAVEHAGTASLPVATHSLPAVTEIVSSRASSSSRPTSASVSGDFGFFSILETPETTVDIEMVEKFRQAFAFDDKESLLGIFPGYLFRLLPVYGRLYVSNNYFCFKSSGPLTSRTRMILPLRDVLATEKHKSFRFGHHGLVVIVKGHEELFFEFVDEERRDAFISVLQRQMDSARQRTKSGDTRTSSDGRQDALILEEFGPRNPLSMSESRSSSSESAPAHMFTSQSSTFLSFKPDKPLRFTFLTIGSRGDVQPYIALAKGLLADGHRVRIATHGEFKEWVESHGIEFGYVGGDPAELMRICVENGTFTVAFLKEGVQKFRGWIDDLLKTSWEACQGTDVLVESPSAMGGYHIAEALKIPYFRAFTMTWSRTRAYPHAFAVPEHKMGGNYNYMTYVVFDQVFWRGTAGQINRWRRDTLGLPSTSLDKMEPHKIPFLYNFSPSIVPPPLDWPEWIRVTGYWFLDAADVSSKKWEPPQDLLDFISEARKAQKKIVYIGFGSIVVPDPKAMTRCVIDAIVQSGVYAILSKGWSDRLVKNAPAQTEPEESLPKQIYPISSVPHDWLFKQIDAACHHGGAGTTGASLRAGIPTIIKPFFGDQFFWGDRVEALGIGASVRKLTAESLSHALREATTDQKLIDRARVIGEQIRAENGVATAIEAIYRDLEYARSLVKGATQRNDEEYFDAEHATIRDYPASSTLPEHPSPCLSASGGVSDWSVISDSDDGPQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7L9</accession>
    <name>A0A2G8S7L9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07987</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7L9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7L9"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000024">
        <property type="entry name" value="Calcium/proton exchanger, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="50"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="306"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="260"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL29782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="462" mass="49638" checksum="5DF4D19D1983A92E" modified="2018-01-31" version="1">MPPKPVGPAPPLWQGLKAIVLMSWINVLLVFIPVSWACHFALPKNDKNDTLTFVFSFLAIIPLAKLLAFATDELSMRVGQTLAGLLNATLGNAVELIVAIIALVQCQLQVVQASLVGSILSNLLLVLGMCFFAGGTRFSEQGFGMSVTQLNSSLLTISVIAVLLPAAFHTAAGDQIPDDQEAKDILAVSHGAAIVLLVIYISYLVFQLFSHKDLYDDNHPDIFKSTKYQGRLGRRRTQTAPTPALEPDASLVPLARITSDGLTTSPPTSPPPRHQELGDAESPPVSHSESEDEGEETPQMSVGLTIGLLVVVTVIVAVTAEWLVDSIDGLTDSGKISKEFVGLVLLPIVGNAAEHVTAVTVSVKDKLTLSLGVAVGSSIQIALFVIPFMVTLGWIIGKPLSLLFDPFESIVLFLSVLVVNYVVQDGKSNWLEGMILMSLYVIIAVTFWYYPGVDSLRQLLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7N7</accession>
    <name>A0A2G8S7N7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7N7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7N7"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="293"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="462"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL29786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="656" mass="72029" checksum="C9E770F39E4FAEE6" modified="2018-01-31" version="1">MAQPAVAPPAASQGAKTKTNAKKRYLKAKKERRKKRKALPEKPLASERTTARKKRNEEEESGADESLSGGSESEGASEAEGVRSFPEVALTAPHAQMAAERPRKRRKLDAGEPEEPRALSPEEDEPPAKSSLAPCAQSPTPPAALPAFPQPRRPEAPSKSVLALQGLDKALIEAEVIDPATTVPLDAGAKEALDERTGLSGRIRNRLKDLGITELFAGLSRFFALYRCTTYVESAGIVQTVVVPLLLSSSKSRALYRPYDPPDDICVSAPTGSGKTLAYVLPIVEIFRLQGGSSKVDILICTPGRLMDHLNDTLNFSLQHLRFLVIDEADRLLAQSFQNWLAQVLAATRPPRASDDTESTAGGLRSVDAAAQGHARPDSLAPAFLHLLHDIDYVRTDFDEKKESSCQKLLFSATLTRDPAKIAALGLRQPKYIVVQSPKTSAMSKEEGVLDFVMEKFTMPASLTEHMIVCESSVKPLMLFHLVHTRSVTNALVFTKSAESTTRLVRLFEFFEGSRQDSRSKGVVARAYSSDLAPGERKSILEQFKNQDIQILICSDLISRGIDISHVSHVVSYDVPVDFRKYVHRVGRTARAGRAGDAWTLVEEQEARHFKNMLKEADHLEKVKRLRIGDTDLGPLKPAYEAALTRLKEVYARGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S837</accession>
    <name>A0A2G8S837_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S837"/>
    <dbReference type="STRING" id="1077348.A0A2G8S837"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF38">
        <property type="entry name" value="OS01G0614300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="471" mass="54247" checksum="C34641A50E899038" modified="2018-01-31" version="1">MVAFFKTDAVPYRPLFSAPRSLSSKFFALLGFFSVVCLATYFLPSSYKPSFPSLRLPPSRQRSTCTPESWAAGQWISKPPPTTRTNLTKPEEAYEFLGLEGCASSREHWWHLAADKPALYDRFPGVASWSWSPPSDCAVRDLDSSAIVKDLVEQGGWLLIGDSVTENHFFSLSCLLYPHVRATPDYNEHPYYGRDHPQNLYLKRTSPLVSKIRFPSGFDIEKTPLVTFRRIDLLMEQAQLDHLYHALHPDSKYVRANESIFSDEATWNQSPAEYVKLFTTQLPERNYATMIVSTGGHWTTTLFSGLKDTDMFKDGIQNVLDFFSEAMEAWARQVQALLDETAREEGRRWRMQLSSFTAPRRAARQVVVRAYLPGHEDCHDYRAPIEEYKKGRWGWYNWNQIGEYNDEFKAVLESRKYPDIHFLPIDRPALLRPDAHATGDCLHIMSGAGVLEGWTHYIWHYVTRELPGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8H3</accession>
    <name>A0A2G8S8H3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8H3"/>
    <dbReference type="OrthoDB" id="2757830at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="564" mass="60047" checksum="47B6CEB95C770050" modified="2018-01-31" version="1">MSPTALNNDILLSITSISPPKVAVSIMGTCRLLYHEGAKIVLQSPVNLDGSEQEALALLRFVQAENLTRCPYVRTLHILMDAVPRSVANVLAKVVPRLTGLDRLALSGDQMFEAHPPLLPLFASLRSVKTLLVLDAGERCCKLVRTLQSALVSATIHFERMQAATLSLTAATHPVLLLERSAATLETLSCGFLCNTNPELTFFPPPITYPKLRSLALANSIYPDPIPFIRAAPNLADLALENGTMVISGGHLHMTELQRAMNLELQGDSSSSSPSSSPSSSPSPSPFPLPGLDFGSAPCRWEHLEAFKGRVVDLWMLGLACRIPSLLLTDAPASRPPSALTEALAHARPTLLQLSFRGQPLTDVLGPPDSESSDFKTALRAQGAAGMNMNLNLKRLVVQVDVMPQDRGMDVGRALDELASVISDSGLDLCHLQLGVHDGGLSNTAAPASSSASAAHQHGDTTSTSTSTGAAHACASCACSVPAPVDRASLSVAERTLDELDVHEYAKRLMGSLPSLTDAVVRIDRPDRCGGSQRIAILGIGREVMMCTGGELVYREITTAQHEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8U3</accession>
    <name>A0A2G8S8U3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8U3"/>
    <dbReference type="OrthoDB" id="2757774at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="81701" checksum="EFA5D0EBB335D4B0" modified="2018-01-31" version="1">MFDGVFTPELAARLSRLTLCLVCHDDDSDGEDDTADVAQLLWGGFLNTLISALRPLHNLTHLRLVVHCKLVKRPAGSATSLPYSHSESFVDTVRGPAFDFAGTADALVRTLPSLQYVFLTTCGSLVDRGENKSNSGRPSLREHERWNVGRAWRVANADLGQPQGTRKSTTTLPRTDGIRDEDEDPPRGRLVELHSDVSDTIIRNEELVLSDADEKFHSFLFADAAARAPHVRALCIRNWRPPPVQTLQAANQVNLCIVSLLAEIVNSCPRLVHVSISLDFNSIHDRPLLAAIAALRTLRSLTVTGWCTSTLRLLREVSSPICTLAISSLHELDPASLEEFLPRFAQTLEKLDLHNFRPCRNLVDDIMPGSPGFFRNHTQYPAVRSLSIGRCAGPPLLDHLQHLFPSLNDTLLVGGSDSALDTRAHEDIRAANLRAQDGSESPSHVWKKFDRVICTPSVLHLLALRCPIRHLMLDLDYYAREHSLRCAAEALRENPVPRLKLTLRCRRGMFDGVFTPELAARLSRLTLCLVYDNGNNDNQRPGTEDDAADVTQLLWSDLLNTVTSTLRPLHNVTHLRIVVCCKLVKRPAESESESESSGPSSTSARSLLYPYSESFVDAVRGPAFDFEGTAMAAALPSPALQYVFLTTRGALSFQRSAVHERWDVHRAWRVGDGAGRPASGTCGSISTDGMHAYDTDVDPPSGRLQLELVELHSDVAATIAKNEELVLSDADQGLLFPPIGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Z9</accession>
    <name>A0A2G8S9Z9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Z9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9Z9"/>
    <dbReference type="OrthoDB" id="2733483at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="25824" checksum="77CA91AF74FEEE03" modified="2018-01-31" version="1">MDRPKLPLDDAFLDLGQHCNNCGKRNWGGEKPKRCGGCGVVVYCDRECQRAAWKAHRLLCRSAPEKDTSLSKELGYATPMALGMALGEWLRIHAWSLNTLVDSSVYLGGGIDTLLSPRQPAFFMVLSPKHATANDGNPAEAFEIFTYSIMREGDYPTLRELWGKMEAQYDAVARTLRAQGFFNEPIFGGLLPAMYVIPEIGVCVFQTHAILRFPILHVKDDPQDERTRAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAC3</accession>
    <name>A0A2G8SAC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAC3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAC3"/>
    <dbReference type="OrthoDB" id="5599163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="7">
        <location>
            <begin position="431"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="899" mass="101641" checksum="E732C8E13CBD51CB" modified="2018-01-31" version="1">MPDPRAQQFAEIPELPPLVLPTHPPARSTLPLDSRMTRERLDGLLATIEPGFLSEEEVDLLAFVVVSYSRAFAWEYEEKGFFDPQYFPDYKIPYIEHTPWQVPPIPLPPALRQAVRDEVRRFEDLGRFEPSTSSYRSPLWWVEKKPGSKPPIRLVIAVEMLNSVAVRDASLPPNINDFAESFVGYSIYMAADMFSGFDARILDVSSRPLGTFHSPDGPKQQTTLIQGYTNSIQEFSRCTDHVLRRLKARDWADNFVDDSSVKGPRSRYNDEPIPGNLHIRRFVFEFAERIVAFLAALIAGGITISALKTVLACSRLKIVGSLVSLEGWQVGSGLVEKVLRWPVPESISEVRMFLGLAGGARRWIKNYARIAWPLTTLLSRPADEFAITPEVEEAVTELKRLLTSAPVLVRIDYEKATLITRPPRDSDDGMLVVGVDSSWMGAGWVLYQIVDGIKRVALYGSSTFTKPQQNYGQPKSEVFGTFVALKALRHRVWGVHFRLENDASSLATMLRKPDDVPNAPMLRWVSWLLLFDFEIKHVPAASMKMEDALSRAPQIDTGLSDPSEDVDEFLEAYDLHAAVPRTGRSPAMFSSARSMLRSLQLTHSNPFAVSSQYAPFMTTYSASTALAFHSGERFNPSAPSLLSSAPASLLALCTVIFSTAYHPEGNAPVERSHNTLTTSLFKVTGDAKGRWPLYLAPVLFAMRTTVSRATGFSPYYLLYGQYPVFSYDVEEVTWQTLNWDEVHSHEDLVAMRARQIQRRDINLEKAHDRLRASRKKAIDDYARRHHHKFDFADYEEGMYVWLRESKLDEIKGGKGEWTYAGPYVIHEKRGRDSFILRELSGAVLKGHVNIRRLRLFFFRPDNQTLRARIRTPPEHDARRTNPLSTLAAVYAYRAAHGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAF9</accession>
    <name>A0A2G8SAF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Chorismate synthase</fullName>
            <ecNumber evidence="4 8">4.2.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8"/>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAF9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAF9"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL30731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="414" mass="44225" checksum="93D0EA44374FF01E" modified="2018-01-31" version="1">MSTFGTLFRVTTYGESHCASVGAIIDGCPPGLPLTAQDVQVQLSRRRPGQSNLTTPRDEKDLVHLQSGVEHGITLGTPIGLLVRNEDQRPKDYSETDLYPRPSHADWTYLEKYGVKASSGGGRSSARETIGRVAAGAIAEKYLKAAYGIEIVAFVSSVGKVQLPSAISPPSQVPPEDDDAVEDALSPEFVQLLKSVTRAQVDEQLTRCPHAETSERMIKRILRAKEANDSIGGTVTCVIRNVPAGIGEPVFDKLEAKLAHAMLSIPATKAFEIGSGFRGTQVPGSKHNDAFALRADGRMGTRTNWSGGVQGGISNGEDVYFRVGFKSPATISQAQDTAQYDGTPGTLAARGRHDPCVVPRAVPIVEAMAALVIMDHVLIQNARKTAGSLLPAITTLPPTMVKPSKPAQKEELNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAU6</accession>
    <name>A0A2G8SAU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07055</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAU6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAU6"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="10">
        <location>
            <begin position="13"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL30886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="230" mass="25066" checksum="B035784C8A69B56C" modified="2018-01-31" version="1">MAAEGARSAPTEPIVIAPTAEHRATVIFVHGLGQSNSQWVPTLRRVVERLPAVKWILPQAPNAPVTYSQERVRPSWFNIASLPPCNCYDETGISSGVAKLENLIISEVRQGTTSSKIVLVGFSQGASLSLMTALTTLHELGGVASLSGWIPKQSRPAMQQIEPSLPVFWAHGNADDEVPLPYGEECVSFLRNTLEMSSERVVFKTYDGLDHSVNDAELDDLAEWLANIMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAX3</accession>
    <name>A0A2G8SAX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAX3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAX3"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="92"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="467" mass="52431" checksum="A3955BB42E219A67" modified="2018-01-31" version="1">MPAFRNIRRSRRISKQPPRDPSTDEYDVYDLELMYPDSDGVDSDPAPSSSPPTRDPPLPLVDPQSPHPSLLSCSGSSPTRSSHSRKKKPGHIPRPPNAFLIFRSELWNKEKIKGSVERDHRQISRIAGRYWQELSDAERAPYHVLAEKAKRDHAELYPDYKYSPVYRKDKATKRKAKAEDTEKVLRCQRVALLMRQGFVGDDLKRELEKADAPEDDDTSDASDYVEAPRRKRARTRKSYTKKPSSAQRSRRSRDISASVKEEVMDENDIPPEHLVSPVVDTLILDAHTSSSPIVDCPVSNVDPVVNSPALDVTPKQEQSTPLIHDHGGFVPQDEIPELRLGSPAFSPKVEFTNPFAEDSGSPSRNDAAFFTCDPLSPVISPLHASPSSDFLGVAFDEAPVSMEASNLDCTYDVELFDVKGDPLRPAVDCLKPDYSTMFGAEDIYSFYLNDYTNDEPSDHVFSDWVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB75</accession>
    <name>A0A2G8SB75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_05709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SB75"/>
    <dbReference type="OrthoDB" id="2420415at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="709"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="813"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="897"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1316" mass="146090" checksum="90898C616DEC539A" modified="2018-01-31" version="1">MTQDLPSSSRLPQKSSDSNNRPRSHPNSQAIDPATFYGSSASNLGSATTSYIPPESTSFRQPELVEEEPIPKHTATWDPESTTWGGEPSDGWGNLDTLGPWGDPPVVSVKVAIDGRDDYEETHWYDPDVRAIYTRPGTGVLPPLLADMLHDPDHALYSVSTQVHPTLVSPAAPFTPTADEVRTAIPHPNAYFCREHNGWVLLLWKASTVLPPLVKEPETPVPDQSRRKRTNSCVGDGEQIFGQANLTHHWHRYEKAVDATKLNPPYAHGELLLDLYLCCQCSMYCLVSDVIPGVIPVSLVNEFTLDKIGHPAIDKTPKATAVSGWETVLTIIDNRLWRDEQRSLPVGRSRFRAKLGWNDHVERVFAALGFPLDKLNQPDGKPDELALQPPPVDPSTAEGKASRTKLLRAWVEVSAWLAIYEKANKDGLKDYNTMVIHVKADSERDLYQTGIGAHVSQISRGSLPEHVIAEAQSDPSWKALGMTPSTYSWELLVFAYLAQCRCDPANTMVYFTHLVTIVDSLINWRAGEPDQLQAFIVQEKERYRFTLKEHDDYARRLGFGRNNDLGVELDSDVDDEFIAQAWRSARQRAWMSPGDASRRRAGLNDALKVVAEQRGSTALIKVWMEEKGSGMSPETAYSTLDVPRDVDETMLLTVYSMRIEDQPSQADRMREALNIIAEVTNSERLRQFLATGRDPGDTNILNTSPEMPRGLNQLGNTCYLNSLLQYFYTIKDLRVAIASLATADAKFLDDSKFTDDDLKRHRVGGRLVTRREILRSKKFVNLLSELFWNMEFCETAAVTPAIELAKLALVTSQDEEEDETDKAGTDSSNDTDATLVDDMAPRPVFDRSSPPVAPVQSPKSPTGSVLGKRARDGDGDADGELPMDIDSSPAHSPPGPSVASPPSTKASGSSGSGRASEDPMSFIEDAIGSSSKRPAAGNGDGDADPDVEMKDGSPPSQAAGKVPPPLPPRKRQAADSVMMFGRQHDVSECMDNCMFQIETALLDFQGMAASDDDKTSPIKRLFYGKKRQRLVSLSPNDDARHQSSIHEKEDLFSQVHVNVAEEGFDLYDGLARYFDDVVEIGGQKKQMEVSIVDPPPLLQVQLQRVQFNRETQQAYKSQAYVKFGETLYMDRFLDSADPGKKARSKAIQTELTIARERHAPFAPAFANTAEYLTKQGVLDLALDDANSFALSLAREESLITEQLRAERERTAALKAQMEEIWRDEAAAAYELTSVFIHRGSSPSWGHYFFYSRNLPGRPDEWFKYNDSDVSAVSKDEVLADTTGSTANPYMLVFVRKGYDAIDTVHRFNPDSLQEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC17</accession>
    <name>A0A2G8SC17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_05989</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC17"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC17"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="360"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL31291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="642" mass="72357" checksum="AD580AC7136D7467" modified="2018-01-31" version="1">MADDPPHKLPANRLGEYTVVDEIAEGTFGKVKMAIHTVTGQKVAMKFISKHAIAKHRTKTRVQREVEYMRTLRHPHIIKLYEVISTHTDIIIVLEYAGGELFNYIVANGRMAEPEARRFFQQLISGIEYSHHLKIVHRDLKPENVLLDDDLNVKIADFGLSNEIKDGDFLKTSCGSPNYAAPEVIRGGLYTGPEIDVWSCGVILYVMLCGRLPFEDEDVQTLFTKISQGVYHLPSYLSHEAKALINGMLAVDPVKRITIPEIMQHPFFTADLPTYLSPMPQQGPVLGTLSSLVAPPRALEFDFIEGLGRIEDEVVEELASRMDGVDKEDVWECLRRDDGPQGNAVKVAYMLLRDKRRAGRSLAEYEEQERDAKLAAMDPRHPLSPNAVSPGGGTDLEENPFDSEFNDYDEDDEDGLDFSTPQNETDNNTFAVLNSSLPEQLPEPHHLQSYATAKRSWPTKEKKQHRTKWHFGIRSRSPPMEVMLEIYRTLKALGMEWKEKTDLGGLGASALLKEKRGTDRAKIERARELDGYVDLRAASAIYFIETRARVQDVVVLMNLQLYMVDSINYLVDFHHKKTYKALAEPGAGKFDMAHPDCNLSETASESSRSVKDLILRDEEIVSPFIFMDVACRLILELAGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCE9</accession>
    <name>A0A2G8SCE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCE9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCE9"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="150" mass="16356" checksum="17AAFD49DE064BF8" modified="2018-01-31" version="1">MSGIVLSKEFAYPAAAAVSTFWLLIWQTFRVSRARRAAKVDYPQVYAEKAEAAANQAALKFNCAQRAHQNTLETIPMILTSTLITGLKYPVLAASLCGAWTFSRIFYTIGYSSGDPKKRYMGGNLLFGIVGMFGLLLGSTATVVSFVRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD06</accession>
    <name>A0A2G8SD06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD06"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD06"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="65" mass="7218" checksum="248AADCF0FE3E71A" modified="2018-01-31" version="1">MSDYKKLLELLPPTSPDAVSIRRSLAALPPRVESAQKRETAEMLDKLKGLGNSLLVSEEDRPERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD65</accession>
    <name>A0A2G8SD65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD65"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="118" mass="12361" checksum="67C554A9A5A40A35" modified="2018-01-31" version="1">MRGFMGVSPMIVSLRSAGWSSPSESSGLRRGAACPVKESAAWDATRARFSLTGEGETCSPRRRLRARVTGESTAEDSGRCWAKRRGSMGGNGSGEEERRGAGGLFFGLDGVANGSEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDC2</accession>
    <name>A0A2G8SDC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06447</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDC2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDC2"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1183" mass="130500" checksum="DB17284D7B7F02BE" modified="2018-01-31" version="1">MPDSESVRQRIVSSVFATKLVEETYVAHVKIWEEDASDEGGKKPRYIILSKSNSGAGFIHKSKLNSNGSFSVGKTWKLSELRGVEVLNPLAFNITMSRTYRWQTENQQHQSNFISDLIRLFGSITGGNAPLELVGVRDSMNESSSRPPPLTFNRMERAPTPTNGAPLPPTTPRRAAAAPNAYPDSSQTSPYANGRVSGGVSNYQPSTPGVSRSTSRARRPRSPPRAESPDLSRAAPTVNSERVSTPSRPRPSTPSRDQLPPPSALRPRHARLPSNVTVDTSTSSRTSAATTSSQVPSIVYPSSATTVQSESQSPYTNGFASARGSGNLDIPSRAASPASSTLQPSPMSAYAISPGGLVSAQSITPTPSVAQSITPTPSARPQPPPQPSRSPIEQTPDSGQRRENIRVSFYDPPNQATLNRVLSGDALLHETVDEEGEGTGVVEDESARATLESVEEMLEGYEWASDDILGRRALTGTVEQIEARLLDELMALDKANIHSFIEGDDRIVTVLKFLDDAINELDNMESVMSSYKIHLNAVSDDIAYIQGQGRGLQVQTQNQRALLNELEELLQTVQVDSDSLLALTQESLEQTWSIKNLETSVTVLYKALLAGRDRDMAATMERLDEYRGYNAQFCKRVLDYLSIVFTAQGKMLLGDDNGVSKSVRGRVSLKDHRNFETYLERYRGLLLYLKEMDESAYAKICAAYFTAASELHGVQIRALLSTYSAMVKKAPTEEEAEGFSGVTPTSNAAKAAQGMRRAGTIVRSPLERREKKEASDGEIRAAEALSMVLDQLARTIYAEEGWIAKFLQIDDAAQTFADYMGLENYFRRQAAKWAGLSQATTKLVRGAMDLIFGFLPMELKSWLDNAIARDSLQVVGMLASLEKFQSEAEERGNTFLLSLLEKQHMRLKALFERRVNDQIKSIEETKLTSKKRKGVAPFIKYFPTYISRVETQVIGSDTLEIRQSVDAAYDRIVQAMFDALKQMAKMGGDEEDKGQLNYHVILIENMHFFVAEISQIEIGTVAVFLKRAEAIYEENLGAYVKIVLRRPFAKIIEYFEGVERLLKTTAPSEISSNSSYSKSALKKVVKEYNGKDIRKHVDALFKRVEKHFDEASEKTTSEDASASTGIAPGTVMVGVWKACEEELLRITGLFNKTITQCYKDTGVALDYTAGDVEGAFKRHRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDN9</accession>
    <name>A0A2G8SDN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDN9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDN9"/>
    <dbReference type="OrthoDB" id="3258282at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="494" mass="56170" checksum="AD6FB6470F6246A3" modified="2018-01-31" version="1">MAHPRPADPRLNYYQQSPVRGQLENPDGTTRSGWRYIQCTDTPNELRVLLPPRTALIYGHILKAELAELAKDKAANWERIVQIRHLKDRMIRKCTRLSRSTQPKDKPMPRIMFQTVHAPPDFRLKEMERWFRLQGGEVTKPSGEPAAAPYCKDCRECMAHQARMQAYAQQGSVRRSPSFSKQGPPRGSTPERMARRQVTQQAQGSAYNHSNTPPVRQEQRMRGSPPPRGHVRYPSAPAVPGYHPDPPRPSQSRKSSEHLRVDHAARVQARSPDPLPIPYRTRPPIVSPEPEQVPSEPSDPASPSGQLLELPISSSPVPSPRGSITPPKVSSPPNGLPTIHEEESEHRPIVRRRSSLKKRDSMSRLSIASQSKSVAWAMDRDWVDQMSTYIKTSNEAEVLSAELEKLRVEYHDEIEAMRALCLKVEESQERVRQETEQLRENENAVKIQENKILASSEQIEQKQAEFQAKVLAVLEESKRVVQLCDKKRDIHETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEQ3</accession>
    <name>A0A2G8SEQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEQ3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="96" mass="11160" checksum="DD6974A311C9BA32" modified="2018-01-31" version="1">MEEGEGEDEHHLPRIPPELMVAMHILREEEKKLNIDEEMTNRWRGLYGVPGSDAVEDAEKELAKEAKTKKRNQPKRRERAPSAAVIERRSKSQRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEV0</accession>
    <name>A0A2G8SEV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEV0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEV0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="490" mass="53603" checksum="8283BB65B90EE4B0" modified="2018-01-31" version="1">MESEDFVIDGIAAPHTHHTARASFVRNKHSPLTLNLFLLRRGLSGCKYISATGLFRLLDIAIFSSAPGLSNSAPFRRYRLQPCSCPCLFLWLKGRAWSKHRLRVHQLGVKIRRSKLSANPNVTTNATVVAHPIPTILFGLSILGYTSAIYLNLDAHAELDLSLTGAADGSMSTGLGGGNTTTTGTALGGGCVDISMGLAVDVGADVDRLVIFKVGENVMLFGRTWDPYKTCFGDDNLNEKRDYRSLRRAPESGGLGGLRAVRREPFSRTQDNCAESSDGFACSTVLLGNLVSLVSEIVNGASHDCYASTQHPYAPSRVRVLCATLSNTLPAPLAQAVATHSYLPIGVRAEHTVLVRYLTAVFHISSRYSIALFRVSSSGLTHSHRSFARARALVHSPVFSRRLSPPPSLTYLRPRTPYFLIIIPIQPTGFYPTVYPSQRAYPLPLPSLSPIIRPFAHARTSSRHVSLATPALPSQRGQRHMRRQLRVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF77</accession>
    <name>A0A2G8SF77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF77"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF77"/>
    <dbReference type="OrthoDB" id="2793280at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="461" mass="52010" checksum="82A90E930530F4D8" modified="2018-01-31" version="1">MVDACMVPRPALSQPETSQLQLQVVFAGSVSIRHPGRLGATLFAFPAYSHPDPTDSSGRRSGLYHLLALDACRIVTNYAANNRGDFLARDREGKTPVPIDDVSLLTYGNYYYFLGPPEVHANCNYPIIKSFSAFVFPSQLPDNWYTARTGARWQQTLPLPQIVSSTNMSIHVVTRDECCTATKYREFTQCAHLVPRAEAAWFIANDMRDYSGGNERARVNAHTNGISLRDDVHRCLESHAFVFYPAGKDQFMTYFVSPRGYPNYTELLHQRLVTIHPNVAIEFLYARFAYAVIHLVLTKEAFESVPDNPRVKVWEELLALSEARKRAQKAAKLAADGEESPTSKTSASEHPRIFRSNEDPESESPVAPDLLFKSPPGEPLAEGDARWRDRLLARFPQFATLDEVEYPPEGVSVHMETPHMLRLRSKYMQENPQVWQTSTTPEGSTRGDEEGLLARWMTRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGE3</accession>
    <name>A0A2G8SGE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerophosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGE3"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29934" checksum="69E02F83E4F2924F" modified="2018-01-31" version="1">MPFNLPGILAPVHLIINPRLVVPSVVVKDIRQLDFQALYKAGYRGAVFDKDNCLTVPHEDRLVPELTDAWRECRETFGPGNVLVVSNTAGSHTDVGEIEAEAVSHHLCVSVLRHSSLKPSYACIKSIRAYFASLPRPVRDEELVVVGDRLLTDVIMANRMARKARRQESGSGSEDEKRALVGENVPTPGRVGPLAVWTEGLWKREGLLLRTIEKGMLRGVERWVLGPQEKAWRESLQHRFVKPVPAEVGPVKERGWARRLWERFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGK1</accession>
    <name>A0A2G8SGK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGK1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="320" mass="34519" checksum="1498DB8D2E20CD46" modified="2018-01-31" version="1">MSSSGPSLTGVDPAAAASDEGSPSMPIQCPKNPSNEMLKRIAFNANPPAAAVKSSRAPAPGTLARSVALLCLYASSAGDSQRLNIITFVNSEALHSVASYTLSDKLLRVSPAQRKDIMTRFNDLVARVLYGFAVWCLSWNAKPRRNIPASEAAKELCRQAFAAPNNSKVQWKFLVFVFGSIPEFWGLKAEVLDIPNAAAFARVKPVPVHRAVLGSSPSLPRPLGSNPATSVYDTHLGPTLSLPNLRSRATVHATSSDEGIIRNTIATRPAAPTFEARNTVSTANTPDRTPVYSPRMRDRASPRRRRDRISFPLRDATTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHZ6</accession>
    <name>A0A2G8SHZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHZ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHZ6"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="524" mass="59348" checksum="622C5240197A6460" modified="2018-01-31" version="1">MPQPEFVDDPEKALLDTLTPLPVLPVSSKAVIQDAAVGLAAQSGTDARPDLALAMARKDPASSNEPKRRRANRWIRFQLWFNTYRKFFTIVMSLNGTGLLLAALDKWTYPRRYTGAFILGNLLFAILMRNELFGRLLYLFVNKAFAKWTPLWFRLSCTSILQHLGGIHSGCATSGFLWLIFRVTLIFIDHKDNHDAVLIMGVVTNLAVSISILSAFPWVRNTHHNVFERHHRFIGWLGLLSTGPYEPQSPSNLLFERCDADGRVLAFAAWVFVVLGDSYDLDTHSWNPDGMRVIRQQDFWYTFGMTVFILIPWFTVREVKVDIEVPSPKVAILRFERGMQQGLLSRISRSSIMEYHAFGIISEGTHAKYHYLICGVQGDFTRSLVNDPPTHVWTRQLKFSGVSHTSTLYKRGIRVCTGTGLGVALSTCLQNPDWYLIWIGSEQEKTFGPTISGLIHKHIEPERMCIWDSKARGGRPDVIQLVKDTYRSWGAEVVFITSNWAGNKEIMEGCKAAGIPAFGTLWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIF0</accession>
    <name>A0A2G8SIF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIF0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIF0"/>
    <dbReference type="OrthoDB" id="2965236at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013923539" description="Transporter" evidence="3">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31751" checksum="EFE8AEE2A598D69E" modified="2018-01-31" version="1">MASIATSFLLTFMYPLLVHRTLARRKRYQDVGKAQETRVQEPSHKRTPVPPYPTALTCIMWALNYGIAGWVSWGTGLRSMKMAIAGGPLRVAVFHSSHSLLATGGDDHNINVWDGWKNRHSRLAPQSPQTADLPIDTASYPPRTPVPPLHRPISSPIRVECRRLKTRPSDISELRKRTPNLTPGTFNFSDNFSTVKYVLKGHDRDTSFDLTFNGEHDRFWVLATHLELNLSTAGHDNGSIVFKLDREHLPFAMHRDALHHVCVYDNTGSDIGLLSVRKFGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ79</accession>
    <name>A0A2G8SJ79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ79"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ79"/>
    <dbReference type="OrthoDB" id="2499463at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="67"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="347" mass="38992" checksum="2BBFA7D069F76FDE" modified="2018-01-31" version="1">MPLASELEARTARHRETRERSYALLDAARAEAKTKRKYDSAAVRCTMTEMCQKKTGLTPYPEQLDLAECMLLGLDATCIAGTGWGKTLPFVLPLFVSPRKIIIIISPLNALEADQASRFQKMGFRAIAINGTTYNSDIEKAVKLGSYSIILVGPKMCVDTQCSFRDVLSSPEFGKRILGVHVDEAHCIAQWGGKFRPEYSHLESVPVQVTSATMPPHVLKLAHETMNISPLESFHLNLGNNRHNITWKVRYMKAGRPELDELDFLLPTSPDTVTLMRTMVFFDDISLSMKARRWFKKHLPPHLYARVRCYNARRGELSKRLVLQDFQDGKIDILLATEAAGMVSGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK28</accession>
    <name>A0A2G8SK28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK28"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK28"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="37"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="31295" checksum="B7E062A8897FFFC7" modified="2018-01-31" version="1">MAVDDGLTLKSTIRLPTGYDMPLLGFGVYQNYTTHASVSEAFRAGYRHVDSAQVYRNEAEVGTALRASGLRREEVSLTTKCISKTHGYNTTAQAVDVSLERFGVEYIDLFLIHDPHRGKDLRIETYRALLDAQKAGKIRTVGVSNFGIKHLEEIREAGLQTPAVNQIEVHPFCQQRPIVAYCREHGIIVQAYSPLIRGQLDHPAFARLVEKHKRDPAQILLRWSLQKGYVPLPKSATPARIHSNTNLYDFSLDREDMELLDALDKGKAGAVTWNPVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK75</accession>
    <name>A0A2G8SK75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK75"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK75"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="245" mass="27796" checksum="A1355596371AC24A" modified="2018-01-31" version="1">MSLLVATPYPPGSYQHKDLLSILARIQNENPSLRKTLVAHVLHLDRITENRPNAFLNLARLLSPCPRTVLFPGNLSYTPPKNLYKTLVGQQAFSSSAVAGRMHKRKPVVFTMREYASFPFAPLAPVLVSRDDSTWCTERFFANVSRSVDWEECLWQVWLAHFGDVEVKQLQGWAPALPDSTSSTSSWQSENPVMEKIHRRLAAKFRGETCALAIRRFTALRNLSNNADTKKARWLKRVCRGWSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK77</accession>
    <name>A0A2G8SK77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK77"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK77"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31989" checksum="5970037909829B78" modified="2018-01-31" version="1">MFSPIFSVFAPNFAIPVADDTPSNSPDHQPHPIPATQTAIPDVPVTVLRPVFNPDSTTNTRLPNPGTARANVAPTPESPSGTPGWASAHAHATVLQQHCAFFDSDGDGVVWPHDTFRGLRALGLGLAACAGATLATHALFSYPTCAGALPDPLGRIWLARVHRCRHGSDSGAFDGEGRFVPQKFEDFFAKYGQKEGIHSNRLWEAVRAQRALLDPVGWFCTAMAWLLTYMLLRPDEGGFIKKEDIRRVFDGSIFDEIARRRAGEAGEEGEEGVEGQETDAGRWMGKKNGKQKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKS8</accession>
    <name>A0A2G8SKS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKS8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKS8"/>
    <dbReference type="OrthoDB" id="3171993at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="510" mass="57669" checksum="8869C0D0F4A708F4" modified="2018-01-31" version="1">MAEDQAVGFICIVILVFIVVYRWNLSPLNNIPTVGSSWVPGLSYLSAIALIRHLKEILQDGYTKYYGSAFKIPLMDRWMVIVSGPKMIEDIRRRPEYELSFTQAVESLLQYKYNVGSKIRDDPYHLAIVKEKLQNRMLADIIPDMIDEVSPAVQRYIPANGKEWVNMDVSSSAFKLVTRTCGRVFAGSPMCNNEEYIDLSVQFALEMLKAGRALRMFPDLLKPIAAVFINKAVKRTSNLTMLRLRPIIRKRIAATMREKEKDRFYRPNDALQWIIDKAVTRHETDIDITERLLLLNLAASYTSSSSLMQVLYHLAEWPELLAPLREEIEGAIAAEGWTMPSFARMWKLDSILRESQRCNGFTLASLVRIALKDVVLDNGMLIPKGTLLGAPAHPMHYDNAHFPNAHVFDPFRFARMREAACDTESAARHQFASTSPEYLPFGHGQLACPGRHFASNQLKAVLSHIILNYDLKLPEPECGTPQRPPNEYLSLAILPPTGGTILVRKRAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLP5</accession>
    <name>A0A2G8SLP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLP5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="257" mass="26185" checksum="AF57B13D308C5CE5" modified="2018-01-31" version="1">MTGSSPKLSLYSILIGPGACGTTSIRFGSCLNAASRFMRDMPSTMLIKLVSPVAVVGSERTVSGAGPLGVDTDAVRLWPGLGFDGCISSDAVRLRTAPAFARPSAACVAGDIRGGALAALIADCFDIDESRDSDGDPTGGGPAFLNRPEDGPASPGILNEPPIPSMSGGLDTVRFRARVALLTDSLTVSLAYPLSASGAIRDGLGACTEPRLVRFLSLATSASSSAFLAGDGEPARTRYACEGASSSELSRCTAAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLU4</accession>
    <name>A0A2G8SLU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SLU4"/>
    <dbReference type="OrthoDB" id="2554322at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="908"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1070"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1217"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1080"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1414" mass="152684" checksum="972CA48DE551D348" modified="2018-01-31" version="1">MSVLVPPAPRADSTENWDEDFEFSRPTSSATPNLDDVQHDSRSRIQPDPRPRVPPKDPSTPLSKPPKSILNTWAEPGPSTPLKRIQHTENWDDDFQDADSPRPSARRSSQSQSQSQSQAPPNGAQRSPPGSASPVENWDEDFEEHARTGASPRRRTPRKRTSWGSSDDEDESAFADREDDRTVTTRSRGVPFHIPIDAPPPVPPLPSPFPRSPTASVFSVPVSSTGRESSAGYSYSSHAHLPLRPTVSGGNSAAVAARLALLPPSPPIHRERRRLRKKSRPPHNFEEGIFELDDRTEFQEPSRPSTPDNSKRPRDPPATSLDDPLPEVGHTSTGKTPLLSRIGSVGKKWGAARRKRASTGPAEVALRERDEQSRDRDRYPESEGSRPTSFIASSSPGHGSGPKSWFFRGGGGGQGPGSPPQDAPLKHERSVERLLHLMGVDRDRDRDSGSPSPRKRKSRGGAHGREATDSTLPKDLEEAVDGSSVPTSTLLFGGTPRRPTSMHVSVAATASSSGSSWSTRPPVPRHVSYNDGRNRRPATPSSRASSKHRSASASVEDVHRAKKSSTTTRETFDGQSSDAHSIPPPEKPPVDAEKGGRRFMGGMRRISLVGGKNKRRKSVAQDDAPKVKRPGTASSTHEEAEKVKRPDTSTSIRDDTDTTHDNTTPRPPSRVVRSSHDAPLLPPIELQPPSPPRPAGERRPPRLRPITPPRTSLEHTLEPSRSHASLASRSTQAPSSATTLPTIPSPLPSPTRPKPSMSPVQTASLGRTAQVPKERDVPSSTAVPRRNSLGDLKIPARISQAQVGLKRDLSMVRDFATSVEQLKQLQSAYATLASQIRTIMHDPHESHSRPVSPSFVHFPKPSTRSRAHTNPAANHPPSRSQINAAFLNIEAKYRLAWECAELLIDLGGGAPKEEPTPTSPPPSSSHSVPVVHTVPDGRKSRERAITLAGDEQKPAIDPLAHGASPPLASPPPSQWRASTGRHDLSYRQLLLLREMLNNPDPSATMSLEPGIPEEEVNRNWRWGDAMHSTITLPSEESGPPGSQPSPTKKQRTSRLGMRGLRDMLKSLKKSYTQHPPIPPSMSSISASTDSSLNLPRESHTLSIMQVRRTRSSTGPESMASTSRRREIHPNSPYGTTPALSHKSSPRRPSLASIFRLGQKSKPTTAGQSVDDLANQAGLPSSSSGHASRSGTSLADEDEWHRVECASELDHAARSLGISGDGTVTVRGKKGRSPYLFQRPLPVDPDGIPRAPDGSQSSLWSPMGESPQKPSAIPPSVLQSYTRSIKLSDVREVDSDAGDGTHRPRSAASQSQSHTTRTRQAAPSPGPSSRRPPSRGRKNPTGSVRSAPPQAIGMGTGTGTPSPNLASGPLPDVKLAMAPENIKPLLENAREVHTRCSDCIAELEALLGSSAGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM93</accession>
    <name>A0A2G8SM93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM93"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM93"/>
    <dbReference type="OrthoDB" id="3358861at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="218" mass="23365" checksum="E44CE665F5768DE0" modified="2018-01-31" version="1">MVHRPADSRLLTNLLNHEKDYSKHLSILLDYSHASLASFSAYASASSPPTSQVIIAVAGALTGADDALRSYAAAVQRWQDQLKALKSMEDDVGNIVRDREILVNRLIKASKSPQRPARDSASLLGGTSSPSGSSLNITKPEVQVGQKLSVAQAELQACEAHLAAKEQELSAFRARTIRTGLEARCKAMVECGWAWGEMGKEGMRALEGLDLAGGYGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMJ6</accession>
    <name>A0A2G8SMJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMJ6"/>
    <dbReference type="OrthoDB" id="2742223at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="511" mass="55808" checksum="027A7FAC59A8A37A" modified="2018-01-31" version="1">MVDGVSSTLLVPERLQRLRQYSANFRNGIFDHENVDSHPEYVRRFRNVRWGYSTRPKASSSALFGALESAGSFLTIFTRGSSQAGVPSRRWMMPAGTPGDRTRWMEAWAIDRAQDLLVTVEVVSIPTNVGTSRFLEVRFCSLSGSETVRTDHPAAALPCVQVFPQPGTDGRTRIDIHPLNVGASYVVWKLGTTRGQAGKYSIEVFNWKAGEFVSRIDLGTQRVDVALLDDTHLVVLPESSESSPPQHINVYTLSPSAASRPPVTLQLPDFQSNSGERAVSHHLNNSRNPPDPEAHFYGDPSHSMVVLTCYIGSQSSQYVSHLLIPYSALLAQANGIAANTAGSPTPPDGLPTPVPWQDWGAPRCLRLRVPLPVAHPGRAQQHTALIPWGSRMPVFAFDRDGASPVVYVVDINPFVARHARTRHDDSNPNSNSESESESEANVTAIVEDVETALPGVFDPDCAAIPYVVYRFKIPPSPSGAAARVVRMSMTGFTVASDYGGRLGEAEETWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMS8</accession>
    <name>A0A2G8SMS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMS8"/>
    <dbReference type="OrthoDB" id="3058642at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21075">
        <property type="entry name" value="DBD_XPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="358" mass="40892" checksum="F024D8A4C8798CD0" modified="2018-01-31" version="1">MSLESPYPGCDTNGWITDIPAGVTVHKGRAIDLYHLHPADLDGVEFEHSFYQKTGRYFNKYKERDVEWRAWEIHGGPIEYWKFLKREQQRRPSHELYTIPPYSYRRRAQYDLSLLHPPTLQDRYVCDSATLRGLKASLAPWIWNACNVALDHVFLHGRIPLMSCELVSDREPAMRLALSFIHSHPIYSERPTQPLGSSPSMTQLRAVLNQAPIAPAPGSPRWGARIDGLVFDEEGSYYEWDRDFLERVFGAACGVVEELGTGDAGMRSARWEIYDKYSESPGFGLWYDPTCHEWTDNAADWLDDRLSGEELRNHLRSTCPAGTAYNNLLLHNAMNLSVKSLAKLRSPSRVLPTPEPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMW0</accession>
    <name>A0A2G8SMW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMW0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="261" mass="28917" checksum="CD57E791E9C058F6" modified="2018-01-31" version="1">MARGHDTIPALKDLADIFRDHNDACQEMEWKGTLEHVAKAIVKFTQHYLDYKVVTEISSLHSAFYLFRWVWEHRTEARGHREFFPLALRMGGHLHSSLGTAILHPDVDAHRNAFVLKSLTETLQFLSHDTHGLNLVAGLHAGAKATVERMSAQADSLPADSSVKQEFDGLKERLRTISASKNFGHQGSQHATFSPVPDSVNLNAAGPGPSTVMLRYGADLNRQGKSLRAREGYTTSPQPTPKPNPSPQPMPSDSERVQNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMX2</accession>
    <name>A0A2G8SMX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMX2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="257" mass="27000" checksum="77627A21B4993AC6" modified="2018-01-31" version="1">MGILVSFATIGINAATWSLSSITALIQLLLPLLQWLVSNCGSVLSGVTGFPQCVLQDLLLQLRRLQDLLYQLQGLQQLLPERLLLQLVQDLLLQLRIVPKQLLELHGVQGLLLQLQLLPGQLLRLHLLQGLLFRIGLRLLRLLPVWRTSFGADPTSGSGNCNDCCGGCLSQVCQNCCSACGSCASSCVDCAKSSSTTGFGSAPSSGSSCPTCCVNCGADSCCSDCGICKDCCPLCGDSAGCPCCGSIGKTAAKTKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN91</accession>
    <name>A0A2G8SN91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN91"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN91"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="299" mass="33082" checksum="06AD05F837CECE3F" modified="2018-01-31" version="1">MAEPCYNLVYLELAACRLMRLPGEFSRMVPNVRVLNLNYNFLEDPGPLEGLSRLRKLTIIGSRIKGAKQLIRIVRGMKDVEMIDFRMNPCTLGWYLPLLVKDLPGALQPSDRDRPGDLPPALESAQSGGAHPAETRLLPLSSSFHDSRSHRSSNREEKKRPWSDSTSDVAPSTALHGVSPNAPHAVVPISDSDPSRRGGVGTTVGDSQKRHEPGQNELVWRELDAKFRRDLPDDAYVGRLAYRGLVMRACPKIVMLDGIQVERKERDKAERLLRTIFSAGKAKDAGLSGVGIELEASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNK7</accession>
    <name>A0A2G8SNK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNK7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNK7"/>
    <dbReference type="OrthoDB" id="2737043at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043708">
        <property type="entry name" value="DUF5648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18885">
        <property type="entry name" value="DUF5648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013842841" description="DUF5648 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5648" evidence="2">
        <location>
            <begin position="43"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="202" mass="22118" checksum="F0964E8DE3BB2678" modified="2018-01-31" version="1">MKLSIATIALATLYMQVSAISAPATSGAPQPATVPNCGYPTVPFFRAWNNATTDHFYTTNKTEMDAFMTQGYMAQGIAAYILPSDTPAPTAVPLFRMYDAKIGDHFYTTNATYRDLLLGQGNYASEGIAGYVYPDQECGTVPLYRLLKYGEAADNFYTTDEEEVKDFIDQLGYDFMEVAAYSQGILSLQQLVSTAANNDAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNM0</accession>
    <name>A0A2G8SNM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNM0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="72" mass="7593" checksum="A0003549A33FE354" modified="2018-01-31" version="1">MSAVGICAYSTSSVVGNKVVGDRPEVHLVYARIQITLGHSLAIKMPFGYLCVYSRSGGAADGSDCELETRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNQ1</accession>
    <name>A0A2G8SNQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNQ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNQ1"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="518" mass="55002" checksum="688A35D404611610" modified="2018-01-31" version="1">MPTATTTALASSVISLKASHTTHATSSTAATLRSLYPRAARAFLQRDVTLTHSLLTSAFALIQPPASLATCNDALASSRRKWDILRITFETTLFSSPPSSHDPDRLPTSLRANLLLSPEPLIATLHNRSLQLFTPSDRSHRPSSSFLPAQILVTLVLSSLKLDSPEVARGMIEDWLANHGQEVDANDPKGYAKVLELYCLHVLPRLQDWEYAEDFLTYERELLPDVRQQYVQSLRLLRAEAATASRVLATLPDPPSSASSSSSSSSTPVRSPSPAQSDSSASSSSTHTATPNGHGLSSLRPLTPSHGAAPKSKSKSGAGDTRYAQPSHSASTSSIASTATSRTVTPHNAERERDAAAGKTRNRSGGPRMHANGNAAANSRSRSATPARPGSRAVVRRTSFGAPSTESTSGGPSTLALIRASLKGVLQSMPRSRLLLYVVLFVVVPIVSFVFRLRRKRARAAAATAGAIAGGSSASSTVDAVRRRLRGVDGQGNVVGKLWEEVAKAVMDTVRMAGRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNT9</accession>
    <name>A0A2G8SNT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSI_02147</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNT9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNT9"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PIL35420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="506" mass="54200" checksum="0393112234523A20" modified="2018-01-31" version="1">MPTLSRPDPTRGMASNSGPEYTSYLPPPHRLSTLDDPYALTLSANNSPRNSAAASQASLAHSPALPPVPPQDYPRVEHVDPYSDNPAMPLNNAGPGYGGAQQHGYANVDSSYSNNQPFNSAWHEKEQLAIGSLIPRVAALGMDLKLIGGIAALVVIIGVGVGVGVGVANSHKSSSKTSSGSSSTGVVNQTNPNDPSTFQLDSRLKKSFWGVAYTPEGSQYPDCGNKLADVITDIQLLSQLTGQIRLYGADCNQTELVLEAIKQTKVNMTVWLGNYPIPTDPAPYLRQRDAIVDALKKYGTDHVSGITVGNEYMLNYLNDNGATDPNSAVGNAGAQLLISNISDTRTTVQALGLSKTLPIGTADAGAYFNTEVLEAVDYGMSNIHAWFANVSIDQSAGWVNEFFQETNVQPASALTNHPTMYIAETGWPTASKDAGNESNGPSIASEPNLQTFLNTFVCQANNNGTGYFFFEYFDETWKDVQFGGVEGHWGLFYSNRTLKDITIPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP62</accession>
    <name>A0A2G8SP62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP62"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP62"/>
    <dbReference type="OrthoDB" id="3253876at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="355" mass="38599" checksum="1F35284A2901644F" modified="2018-01-31" version="1">MYSSRNTYGTTPPELSNNPFIDHPANAMTRYPDITGSDNPANSQFTSWMNGPSTSSTGTNFSGSYGNTSSMSPQGYGGTPGYQSQPQATGWSQGSGFSQPQQSYGQYPSAPMQQQQQSPSGMPFQPTSSFGQQLQAHVNSAYNTPQPQQQQQPLQYSGYAAAQSPSYGQAYQQGYPGQQQQQHFSEFDPYAQGGQPMQQQTPGANGAPPSSSGFRSQHPREYVQHHKAELETWDSYSWKQAQNSFDDLKRAWEARKSELEARLKALGGAGLFAGGAGGYGGMYGGNPAAQQYAQVENMVKEATLNIDSIAASSFQMQEVFAGYRQSSDVASKRRVREAINAALTSLPDWPQPLMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP92</accession>
    <name>A0A2G8SP92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP92"/>
    <dbReference type="OrthoDB" id="3223825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="37334" checksum="83876DC1900E662C" modified="2018-01-31" version="1">MDALDTKGKEKATDDALFTERLEMLFEQCLGNLRSFADREGRPFEEVRRRMAELHCKFLFGGILSQPSVDDHRERVRSVLEKVSREFESLETLAGVQSFFLVVNPHDSDDQGFLGGTVAGREFWRGHRGCGAPGAEAFKAQCMRITTQRPTAVPVQAILPTVQNTAPRKAPPAREIKNELYAGIRHALRTVSGVRKAEMKWTNHAKLVVYKVRINGWPDNIPVQNPSVLSSTQNKLLLELLREGKLYFSRLEDGSASETNAKDEVSSEREGEDAIFEDWLSEGTEGAGYEAPAPQDDSTRSSPAPSMLHADESQGMSQADNAETISTLKRKRVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPG3</accession>
    <name>A0A2G8SPG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPG3"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="29314" checksum="B66EA6968903545A" modified="2018-01-31" version="1">MKFARSQGERKRARRGKDAPSIDQEVFTRRPEVEAAIKRIFLAFPNDVSDESSEDASTCSYEDSENASTCSYEGLEEDAAEPAAFQPVRPNKVARLFNSLEGFGEWPLEFTSRAARDLRQARDGKMFGIYVKKLQELSRGHFSEDNQKRLTGVPVYIPVYEAKMTGDTRLIYQVDCERDPRNEVERQVLTIRGIYTHAQIDRRWKESLRHERRLASGQPKDAEYKKRCMYRNPPAHPGDNVYTPATWCLRRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQA9</accession>
    <name>A0A2G8SQA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_01563</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SQA9"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="366"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="453"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="585"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="19">
        <location>
            <begin position="1795"/>
            <end position="1873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="646"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="752"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="802"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1009"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1191"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1485"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="1617"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1055"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1080"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1114"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1204"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1232"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL35903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1925" mass="210310" checksum="ECDFA790B23A46F1" modified="2018-01-31" version="1">MDSPRFPWEVIERIIGHSGDHPNTLYSLSCTCRQLRPRALCVMVARVTLKSRDRIFDFCAVLHAKPHLKTLVRSAVVDPTDFAPIPFLRILPNLSELRFTSKETVVALHQSNLTCFRHYATHIQALHLSNLSFSTYLPLARVLLAFTNLAHLTCTDIKIIASEKQLSHLGALRQRLAKRLQLRSLAIDPSSPIRWESHDPSTEGLLFGSDLAPTLESLDLKLTSGGLSNDSWRLLAQLADWSRLKSLVLQVPHKNSGYLPWAIGVLESAYGPTLKEVTLVLGPVSSVPATAKGLSLADTHASNVYHKLEYTLLKFSQPKITWLTKIPMRPGRSSFWMRELGRRFPILSQRGLLALKCETVTDSAIPHGHDDTLRALTISPTGKWVVSGSDDSTIILWDATNRNMAYQWVPHDYTWVTSLAFSPDDLYLVSGGHNARLVVWALSAHARWKAATLEGHTAPISHCAWSPDGAAIASGSFDGTVVVWDAHTFTKRHVLKKGPSRFEARYVTFSPDGRWLASWFFPSGYCLWDVASGALHKFVQSDLTRRVHRLDIAAAFDPGSLHLATVSRRDGVEVWAVETGVRQVVLRHAGEVQDVSFSPSGTLLVTASSDRTVRIWNACTGVELLRLLGHTNIVSKACFSPCEETLSTASDESSPIHTPYDEMRRHTRERTSRSQLPTNTPDDFHIRSGSSATSSRSGARPRRNIGEARENDRGSYIPAVPSKDSNGPGHLSRRGTTKALIGRFEALEEAASSRSSLGYGFPPLDRRGSSVRRSPAGEKKDKGLLPIRESFRNLLSIFKRSKPTLKDLPPPRSARAPAPIPALKADRDDPGARKQQGLTLQIPQSGLAGSDKVVCISPVEAHTGKAGSLLYLSRIPGSDLPPIWMACSAQLHSTHILVTWDTPQGNPSPRLVPFTACTDVRSLTPSDLDPIERALLPAGQTWKVFEIIFEGRAGERFAANSLTERATDAVLLAQENKPRSPLRTEGAYISPLNDTPPLKIALKDVPVTASTAGAEPSPLPRSSQVPPTIDRELPALPTRTTKPPTLPRLDIRNFSSTSSPLSALPTPPTPMSARKLLFPSPNSASAESPQRTQSASIRNLDQRSVVRQRLAQLENASPNVNPRPSTPLSPIPRRVVKSEILTAQTQLGRQGSTGSNFATSILNAYLGPDSAVSGSPAPTSARSSGFRAIAARIGSPPPRPRTRLGLEDAGRGKRDRELEEGPLSPASQYSVDDGKQDNSKKAKPESGMTATPVHELLAVPRRAPVQTRVGAPAEESAAGNAKSEGASAPVLDDIRRGIEVLQKRSATDATNIVSIRTSLDGVLDELRRLPKEQLEANPEDTKAVMSKLGEVQMELKDHLSALHTLIDGLKQAQKSGDGPNDGLDPSAFAEVQEKLDKLLQLQQGQSSEGQVSNIFDAPTAAQLAETVALLSEAREQRTAQMEQQTDTVRYLNELNTWLEAFVKHGTSQIEGVAAGIQQLCRELGPINDPQDQLDVPEGEEPPPPQGGLLSDVKQLLVQNKEREQNAADLHASVNGLLAAVQEDLRKNAEARHLLTTESVIGMIDRQRQDQERMLKALATEWAAPELSNDIRGERLRFVEAMKEATAINVQIHVEEFKKELTREVLLMTQEVTRLQRERQGLEQQIADLFAFYAKQKQAGKGNEVGGPAQNDLVIVDPFRAPLPVQYEFDDIGSLNEEQGNLQMTSSRVESTMQSAASETRPVGVTRSEAWECTREGCTRRYPGLQSREDELAVLHNLVCHKTMSALRLVTSAARRAPRNFALGRRGYAEAADKINLSLVLPHQAIFTSTDVVQVNLAAATGDMGILANHAPTIEPLRPGVVEVIEAGNASKKWFVSGGFATVHPNNKLTINAVEAAPLEAFSAEAIRANLQEALRVASGNGSEEDKVEARIEADVYEALQHALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQZ9</accession>
    <name>A0A2G8SQZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_01803</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQZ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQZ9"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="168"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="434"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="474"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="738"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL36143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="827" mass="90512" checksum="F92F5C264B3242D1" modified="2018-01-31" version="1">MDDGLILNFDLGDVVPAKVGQGKKGGRWTDRLKAKRVAKRKTRAEAPAPSRSDATVSVVDVRPAKRPRKERRLEEHDQEHLGLATTASSTRAPHQIISSLFTSNPKIEKPLSRSAPSILAKPSNAPLDSSTFTGSGLDPLIVAHLSSKMNISRPTSIQRAVLPALLPTLQDTAARDVFIQSQTGSGKTLSFLLPILQDLLPLSSHSYIDRSIGTLAIIIAPTRELAKQISDVVEALLKLRLRAQDETAEESSAPRLTRWLVSGLLTGGENRSHEKARLRKGVPILVSTPGRLLDHLQNTSSFDVGKCRWLVLDEADRLMELGFEETIQGILKGLDGRRNLAMTAVEEGKSMDVGGWDWGRRRRTILCSATIREDVQKLAGQTLTNPMMIKAVHADDPLQEAQGDASEASSQKFTPPSQLSQKYVVVPLKLRLVTLVALLRSLLAQSQSKKGTKIIVFLSCTDSVDFHWHLLGGTTMDEEGSAPSSSEPENEGEDEDHKDSGSESPKRPKKKSSRERVEVKSTLLPDASIYRLHGSLPLQTRLASLKGFSAVPNTKSPNAPSSSILLCTSVASRGLDLPLVRAVIQYDLPTESGATEYVHRVGRTARAGKGGEAWSFVAPSESEWVKWVQTKMQGDAKGQEKKEEGSVALDGVSTETVLRKGFGGKGSEYEERATEVQLSFERWVLRDKENAEVARKAFSSHMRAYATHPSDEKHMFHIRHLHLGHLAKAFALREAPTALKSNKGSKAKTKQKATPSHPSSDRKSRRKHTRATDGSDDDEEVADAEKRMEKVVRAQGRLTKKGGKMVSSGTDEFQLAGGYDLEKLIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR58</accession>
    <name>A0A2G8SR58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR58"/>
    <dbReference type="OrthoDB" id="2434934at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="547" mass="57583" checksum="3143F4BCE9472D87" modified="2018-01-31" version="1">MVFGLWSTAAGKSKEVVVQSKEEGKLSLDPLKPSAQSQGAQPAPPEAAPASSALTEQVEVPALDKVSVSPEESSTVSVTTSDPEPRPQAQRRFSWRVLVEPRNSRDRKPALPPAREEAAKEAAARQEYVEHKILRTRSEKRARESALVVRELIVGPFAAPSAALPKSSKVAVTTASSSAPSQKVQKLKAQLLEPKQAKKVIAHLRQLPSSDVPVVVGRTSSGEEIKAVPHGPIHAVCLPYTDTEAHEKHFAQLDTVEAAVPSPKVSPRPVSRSLDLASTVSGITSVTATSLDKLRHVFKDINVVSLLSVPNWGLGQPGDQPGILAGAVPSAKAIVEGVEEITPQLMAMGYATGRAILPSHDGVYPPTDRMSILTYWWGLEIVMPEPSVQYLGNVPSVAHTVVNFLTALSVANGGVAEILPFIRYISTYIDMEFSQIQGQDEGKGVVCAATWIMPAALVPRPWDFADPPSSKQPGNPSLPAATPAGSQVPETQAGNAKPGLPGLVVTPPTPPASESLGKLAGTVSTEGTTSKAAATAVPANTNRAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRE2</accession>
    <name>A0A2G8SRE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRE2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="101" mass="10707" checksum="EFB8B5A46AD91DBA" modified="2018-01-31" version="1">MGSHACDGTYACCNWARVAICTTAIATATLRFPPSLPPVARRSPLPSNFAAAIHATACHNPAAVTGRLSPVTVRTRGCRARYPLSSRHDRPTPAALITRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRH7</accession>
    <name>A0A2G8SRH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRH7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="75" mass="8229" checksum="19E07066A875F311" modified="2018-01-31" version="1">MERAHETEAVSKRDGFEHTVTTREKERAAPRSRRAPSTSQGSFQARQFGTCSNDEGDGMHGHPPLTVLCPAHGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRV9</accession>
    <name>A0A2G8SRV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRV9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="206" mass="21516" checksum="6D58A5362DFC5F2A" modified="2018-01-31" version="1">MRRLRALAVDSSERPSSGLGDSVPANDATSARLRILSSGFNENVSVESFFPGREGGSAASCTAVGTCTQSGAAGGPSGPGSLGGMYSSFAGGMKPAARTRWMARSLMSTALSDSESPRSWPQAWTCSGPQPEAGFLQRPRKWRAQTLVWGPGGVVAAAAVVEARRGRCAWMRAASEPTTVWYVASVGPPTSAGYMRKRWRVVSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSB1</accession>
    <name>A0A2G8SSB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSB1"/>
    <dbReference type="OrthoDB" id="2755117at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="110" mass="11866" checksum="698F336B19E78822" modified="2018-01-31" version="1">MFTDAYTAHVEGPSSNSDSEPAQPRIRPVRRFAAVPDDADVSSFELDIPVVGVDYDDDELLAAGISTELSRSKLALLVSNLFGALRRTFLEPTATLGRLGGFKLGVQMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSK1</accession>
    <name>A0A2G8SSK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSK1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="357" mass="37851" checksum="90D9B11DD5B28447" modified="2018-01-31" version="1">MEKEVPRDSLQATPPSHSPNATPTPIHPASPATALLVSLEAALPIPPVAALPTPLEAVTQSCRPKRPLGGKLAHRLENVKVPRVDEFQKYPPHLRVTEDYELSFQDGRTLPQNDVSPQDDTSPQDDTSPQDDTSSQDDASSQSNSKSDEEASVMWFDITDEECFNVLQMYLKCTAQAQIAASEAAFKSLPTNHILALQNMTASQARQLTPVSRQPSPVVQGLNHPGGSAIIAESYQPPLDAELTNPPDVGIGSSSPAGASPASMESCSEGPSLLPGPSQVSTGSSVQGPSVPQGPPPKNWHMECDDHMSDDGPPNASNGNMQAVPPPVQVSPLTDTQLTGLNINVLPFANDRFMSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST22</accession>
    <name>A0A2G8ST22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST22"/>
    <dbReference type="OrthoDB" id="2744437at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="692" mass="76915" checksum="06A6E7511CF0FBD7" modified="2018-01-31" version="1">MLQPVDIPRTLEERKLEEQIAYLQQKLRQLRTKSNSQVPIAKLPPEILSEIFLVQAAKIREERLMIELRGDSECPNDLVHKSCYSWLNVSHVSRHWREVSLKCAQLWTWLALEPRITDDIVETLLPRARDLPLTAVLLFFSSRSYCGGCMRLDQLLDHYDTTLRRLEALLPRLRELVLVVDREECEDLWDVLTIPTDSLETIRIEVVGATHLSPPVLVVPSRLFASRTPRLQSLKLSSIALDWPNTLLCSSLRHLDVSRCGMDGDGELQPFLSAICMLPHLETLRANWMRPSATINPDIPPASSLPEEHEIAWLPCLKHVYLSGGNRRIATILMYTRWPVETRMHFTVIDTVAPAERAYFQFAFHILLSKETVRGAMYAFNGFGVDTSLLLWSVAGKITAKDPPDTAVEEPLHLTSNEIPPPRLHIHSDSDSQDHPILLALQTIDLVHLRVLLVLGATTGRQWASMFRPAVHLTTLRVKGQAAFGLPALLAGDARTLTPQDVSLAIRAGLDEWHWLDFNTGGGDGNEAQQTGLIQDAEAQEDLELNAHAAEVLNGAVEAEYESDTIPAAGNGGGGGDEATLSSVLFPDLRAVQIAAVDIALPDGWTGPLPYKYSAVMDLMMYRAKDAKYGLDVAALARCLRIRREWGIEGLAAIEFCGCHCEDMAQLGPLARQGVDVSWDGQPVSGSSDVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUD4</accession>
    <name>A0A2G8SUD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 ubiquitin-protein ligase RNF220 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUD4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUD4"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052443">
        <property type="entry name" value="E3_ubiq-ligase_RNF220-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031824">
        <property type="entry name" value="RNF220_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13459:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF220 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15926">
        <property type="entry name" value="RNF220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase RNF220 middle" evidence="2">
        <location>
            <begin position="57"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="415" mass="45248" checksum="B387BF2038B9283A" modified="2018-01-31" version="1">MCSRRASKGKKRAAEETLTEDEQVGEASFPNATGASQSARSREKQPALPIKKPKRAETRRCPVCEEVIPIRLLGKHAELEAERLEEIIRCIGSTEVLGEAEPEDSSSARTRRSAVKARQSLKPGSSSTAGAMLEETMKTLRTLKKRRKERHARLREITKEDEDEAWWGRGAGGREGQGQECPVCAKFVKGDMDVVEAHVDSCLVFFEEEQRRDRSIGRRGSTDLEMDADVDVDGDEGHYGVMDGVSMRGTGFDIRNRNDQDVDDEIDVDGEDEAVFGAPQFTEQDVLALPADPGEVDGAESDSGTDVEIDVDDTTAPGGSSASTPERDPKKGLSLRDLVAEGKVIRHQVEDAKQAMNEVMGVGDAEKVDLAVELARRGGDQAALVKALESKVKLLEARMGTTYACQVNGLDDSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUJ7</accession>
    <name>A0A2G8SUJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUJ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUJ7"/>
    <dbReference type="OrthoDB" id="3206554at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="365" mass="39419" checksum="5F230AAE7F859D0F" modified="2018-01-31" version="1">MSILPLPAPLELFSLSGHGPSPTLDETFGAVLVGTFLSLMLYGVTLHQAFRYHALYPSDRSLLKFASVIMQILPLSNVPYGELPSMHIVTPYANSIAIRDRSLQILPVLTGSVIGISQAFFARRAYVFGKQYRTWVSWAIAFLLGSFAFCIVATIVEILLTNRGFSAFVPDTWIIAVASAMAVCADFILTTVLIIALRQSRSGVAQLCPGSSFSDLLAGLLTSVSMLILFIFVVLRPADLVYTAISLVSTKLYANALLAALNSRQSLRDQTYHADQSSLEIQTLGAQLQGLPRRAFDQPVASGPPELPKRPRGSHGMETMGGRECPWSEGAISPGPEGLYSDSESASTLWEAKSLRDTSSIATAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUL7</accession>
    <name>A0A2G8SUL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUL7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUL7"/>
    <dbReference type="OrthoDB" id="2752721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="59104" checksum="4389460691A78DF1" modified="2018-01-31" version="1">MSPAILTEDILFHVVSHLSATHSRSARRTLVRLARVHSTFKKPALAVLWRSLPSAEALEHLLCAIGIAQEDPQNDHHGLTHLSLNGTLETHRSGWERFQEYSVLVREITLDPFFVPAQHPLGFGFSSFDPEDTFWGHLTSTFGITSILPCLKVVTLRSSDSVRFSTFNPDTLRFLNPSIRGFNVDVASVSPEGRWKFAQFFATCFSSVEDLDVIALNTLVPVLDFESLPQLHSRLRRLTVLSIQSDELSHLASLQNLEYLSIGMARRDERPPDLPIKLLQLRNLTLSSYQSSGLSAFLANVDVPQLQSFSGSMSQSRQNPKEVYEELSNVLRLLVAKCPALISFSWATDRWVRNDDRSGAGALQLAELVAPLLSVRTIRNFSASFRPYMISYTPSDFRAFAQAWPELETLELRIVTDENEADENEADENEADGNEADENAYADFESLVSFAHHCPRLRRLHIPTFKFDHAADTTATVRPPVSHWLQSLYVETVVLSAKQPEDEASESFLRLMQEVFPEADIDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLZ5</accession>
    <name>A0A2G8RLZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_15226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLZ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLZ5"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="141"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36371" checksum="468E9F4E37053778" modified="2018-01-31" version="1">MPVASSSHSKKRHTRALSSDIEEDSGPSQRKPHTQEEDVEMDDEDDQPRRLKKAKKEKKRAAKDDSDAEIDDEEEEELPLPDTRDHPLDKSQAVKIRAMAGDWAMTREKVHSFSYGFLREVAASVAEFTDGEKGEKALKQIDALMRELLDTEQHLNAHEQALDEIHQKLQRGEEIAGVIDVYEKGVQEKMDAYKTKTSRQKYAKSDNYSKFKQAIYEVHHPDTAMPPLTDLIPREEGDDSDDEDDVQIGGITQDYKCPLSLTHLVDPLTSLGAKQCPATGCNKMLALSDLEVDKGLAKRAKEAARRERAREEDSDDDDDVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMD4</accession>
    <name>A0A2G8RMD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMD4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMD4"/>
    <dbReference type="OrthoDB" id="2804704at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="417" mass="46917" checksum="18E65A278D7510B6" modified="2018-01-31" version="1">MSSLSIYRPTLILFPRLVELSWGDRTFCNDDSDLPGVLGLIGPHLKRISIAGWSLQNDDDQHLQTSLSIISTRFRSLQSFYLHCNQTPVVCRLIPGVLPSSLNNLCSFRCNQIPISADAFLALGQLRHLSELSIRLPALLSWAPLPPDAFPSLHHIEIAALTKNYLALTADIVCFPEVTGAIIYLRDVPTVRDGLPFFDLISRQFSHAVLSVLSIYMSSDANMGLLRQDKLTVARDTLRPLLSFTNMTAMDVNLACPYALDGSFFSELAQAFPKIDCLYLGTYDYCHHEPHLLPLMTEALPPFAVHCPKLSTLGVAFDARQTLTVDDVRDALPYRPSLSEVTSLECLHCPIDDAHMVAAYLARVFPMLDGDYAVDWQRLGPTHPLSIPWQQWELVWREVQEKLPWFRMIRDDERAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RML4</accession>
    <name>A0A2G8RML4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RML4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RML4"/>
    <dbReference type="OrthoDB" id="3259324at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54825" checksum="2203D70C94D263E4" modified="2018-01-31" version="1">MAATPRSSTSSDSFDSRGISPTDVFDPSAALILVPDTEDATAAAFDFSSDEEDPGQADLQVERVRNSSIPPLSSTSIYLYLLAPFLKLGALLIPSLDIPLRAAAPALLLFAALSVFTRHLWYMLARYVRRTDMEEIVLETFARGRGREGRRMALRHAVRLSVQIMRVSLAALYLRLSVDMLLAYFPNVLAVPSRLVTTIVLVALIAPVYSARTLASKSVVYASWISVGAYAAWFACTIYMYTRHIVEPIAYSSSLGKLWDGTPTFAFTFATSSTVPLYASLKGTTEPMTPKPRRSKSFKLLSLLSVILAVAFTLPLVFFEASAKVPRQELPSAELKATVAVFGSIALLFSVPSILITAPALPLPLPVRRATSLPVSKVLVYLATIGLALLPAHVTRIGSDLVLLLAFLSTYVAPALIHITIHNFRRPLSIVIPPTANTTSRPAEPSASDSRHDELLQRKERTMQRRRLGRRLIWDVAVWVLLVPVGGGGLVWAVQRMLGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMZ3</accession>
    <name>A0A2G8RMZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMZ3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="143" mass="15528" checksum="D5B8E00920A0DF56" modified="2018-01-31" version="1">MSLSRTPQDWCRSIRTRQEWKEAPLLSRTDLGRLPRAGTSSRWHHAGCTTAPLLRRSAVLSAEVPNVDQDLMAGSPPTALRASVHALSPPPEPSCGFVQGPHLPAGRRRSVLSSFLVLALRLLPAIDSSDLARNLGPCPLPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNZ5</accession>
    <name>A0A2G8RNZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNZ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNZ5"/>
    <dbReference type="OrthoDB" id="3069822at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF34">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="498"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="610" mass="68343" checksum="7059E43CF1E4C47E" modified="2018-01-31" version="1">MSNGLTSFVPVLTGPNYLQWAPKMQAFLQTTGRWMQPMTKTCPTLVATPSNQDKVDAWNEDDTAARGSIRLRVDDSIGTAIDSKTTAKQVWDYLKDTYGKPGIPVVYQDFRAAMGISIPSDSNPIPAMDKLHAHFQTLETNQFTVAEHIKGMILLSKLPSAMDPIIQVYTSGLTATQTTPAIQLVTFDEVRNRVIMYWEQRQGRHQQRPRDSTNKISAVKCKPQDPTFHQQQQRPQGQQQHQQHPYGQQHQQQRPQGQQQQGHRGRRGGRGRSQQHQGAHQHAHIAHVTDTFPVITKGEMDTLPQSRDPRALLHKPVRVETGANHQYPALRRAFTLAKELGIEPMTERIRKLEMLVVAGNRSKDPVLTPTTKLHSTRSSPESSATYSKDSRTTSPNVSCSPTPFAGSSVRIVEVDSGEDMDGEEHAAKRRRRTLKERIRPHLRERIGAVVEDEDMEETVSLGLSSEDEQDNDIEEFFDPCAKCKGKAKSIVNHDDSIWMLDSGASMHFTYSMGDFADFRYYKAKRPLNTADGMTYMTGEGTVFLLLETGGTLRLTNIALVPNLTNKLISMGALLRSGMSARATTAKISLYSNHERVVSFEPREVGDTIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPZ9</accession>
    <name>A0A2G8RPZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPZ9"/>
    <dbReference type="OrthoDB" id="2985022at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573922" description="Transporter" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13465" checksum="8FF36F00309CBF55" modified="2018-01-31" version="1">MQFSTNFSPLALFTLALASVATAMPFDATTDANLTYVGAPINPLAQRQSTTMVTYCTKRVGGVCGGSCSVYNGGPTCIDASGTSCLSATNNVGFCDRARCGGSCHDLSTCGTHLDKNFCATPGTQSILVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRB8</accession>
    <name>A0A2G8RRB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyrroline-5-carboxylate reductase</fullName>
            <ecNumber evidence="5">1.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRB8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRB8"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053790">
        <property type="entry name" value="P5CR-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="7">
        <location>
            <begin position="189"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="299" mass="31779" checksum="DF0CF31905EE539C" modified="2018-01-31" version="1">MGVAILSGVLASLDAKTSFVPQPKWESHTSGTVTPQTLEDDSLPSRFIACVSREETAKKLRNAFVTIGHLGRNVEIVQARNVEAVRESNVILLCCKPQIAQTIMSEPGMKEALEGKLLISILAGVTIAQLQAMVLPSTKVVRAMPNTPCKIREGMTVVSNLPPSDESELERSIILNIFSSIGRCRFLEEKHFDACTALSGSGPAFACIFLEAMADGGVMMGLPRAEALELAAQTLQGAARMTLQAGTHPAQLKDAVTTPGGCTIAGLLAMEDGRVRSTIARAIQVATERASELGQPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRE2</accession>
    <name>A0A2G8RRE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRE2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRE2"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="260"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="549" mass="62068" checksum="D41B2F3388A0590E" modified="2018-01-31" version="1">MPRRTQPTATPKKLRQGKLDVFLSSSPGHQSSPARPQTRRSKRKATAKDSDEDEAGPSHVPANADADEEGSQSSDAGAICFEPQVVVITSSEDNGDLPPRPTFSSKGKKRTKRAHSIESASTPSSQGEEEREVYVRKGKRAGKKSAAAVLDSDEEEELRPVKKRKLVKGERPLTPEEDDLMDEVDEHRIIDSRLRTRDKRSAFQKNLEKLRRKKRGETIQADEEEDEEEEEEVAPFAGARPDNDAEDSPGEDVDEEEDTFIVEDDSVQVIDLPAEFSMGTYQDLLHHFKIVCQMFVHILVHDPEDREEAANKLRESAYILRCLLHYQTSSLVPPTDQYFSVPLKIARRKLSGMRDSLVAGSTWKPRFRKALDTYPNFESQHLEFTVLGCDACNLGGRKSTIQGRLSGEPYDPQTYEASAGSACINIADEPSSDEEEESGEVKKEFDLGRFCAKRTRTYHRFTHWEYHLFHALRDEVESLKDGQEDRSFVRVAYAKGKQPPADLSDADATMDWLDERQVINIQWQEIKTMMEDARHLEVKGAKGDDIDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSG5</accession>
    <name>A0A2G8RSG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSG5"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="209" mass="22552" checksum="89CE91E2B890F61B" modified="2018-01-31" version="1">MPIPQAHAPQMPLPPLIPHPYPPADLASPQPIPRTQPIPPSHASSTPPHAPTRDVASLRVPLPRTGPSFPWARAGSAPTSDQDRSPVFLGVAAFRNGMHPCKIRPNCSPMTWVSYGGKEYPHTGAAYLLPFDRSTMEWVPASDGRVPPGRTPVDGGFEQVGGQRLFHALALVQGVKVPGKTGTHIHGANVPFGNREVQVPSYEILCWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT02</accession>
    <name>A0A2G8RT02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT02"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="15037" checksum="6B295A4DC6DEF722" modified="2018-01-31" version="1">MRRGMLSAFNDNSTFEAVLLRDVLSVSGLAFQHASDVIQFVYPATGVLVSRFLLDLQSANRYVLHLDSSFDPNVETIVFDHATFSAASLEAPGTPSHSSKGLDVDGQKLVSPDSEGLFSEHDLGTAGTREGKDLEGGVPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTK7</accession>
    <name>A0A2G8RTK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTK7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTK7"/>
    <dbReference type="OrthoDB" id="2669721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1086"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1098"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123658" checksum="1FB58BC6536861A8" modified="2018-01-31" version="1">MQQPPPPPSPPRQLLPAAILPGEQVREEQYFCDCQQCGGIALPVSKRTFDRHRDERHTPDEQLIAYGSRDTGAPLQGPALHAARSIVPTLGMHAPPVQSTASAFAARGMPRPLVAPTSPASMRRVPSAPAATPTAQLQGVQRVPPGPSSATQQGRPEPPLIHPRSPRGGVQQAASPRRHPTLSPPPAGSPSSRRGQAPTMGTRGREDHSEDDNSSSSGESNGDEDEEPEVGYTEDQGARGDAHRREFYRTQAFIDTLSTATLAGSGLDDNTLARLHNGRTSIPPMSRGQRAGVRMFLARGDASEANYADVRAAMLEYVEDIPVRTDPVPTYEQVKKLIGELTGITSIQTDMCPNTCVAYTGPFSNLLACPKCGESRYEALQAMWANPESAHAMRHRLTETDRIVRLLRASAQGGTDQEISIPVFDDIYFGKDYLDAFQSGRIGRDDMVVMFSLDGAQLYASKQSDCWFYIWVLLDLSPTLRYKKRYVLPGGVIGGPNKPRNIDSFLFPGLYHLAALQTEGLRIWDSVQRRTFRARVFLLFATADSPAMAYLNGLVGHNGALGCRLCCGQVGRHKPNHPIYYPALKQPRNDPDAPGDITLAVNQPKASERAAVRYRKNLEKVRKARSKKEYAAARLETGIAKPSIFSGLPGFLGVPGGFVLDLMHLISLNLTDLIVSLLRGTLSCEHPDNKSTWDFAIFSNLDVWKAHGQLVANATRYLPGSFDRPPRDPSKKISSGYKAWEFLLYVYGLLPGLLRHLLAPRYYRHFCRLVFGVRIVLQHRLLRVSLPPAQIQLVAYVHEYEDIYYQRRLDRLHFVRPSLHSLPHVVPEAFRVGPGALHSQWTMENYIGNITREIKQHVTPYANVAERALRRCQVNALKAIFPEFDEPETLPQHACDLGDGYILLTATDTIERSVSIPEGNEILRFLQEQRVHLEDPHWHPIVRRWARLRLPNGQIARCVWKECPLEARGRQLRRARMLANNYFAEVQYFFRYQMHGHTETLAMVLPFSAPDPAILDYSRLTLLACTYDGSAPRIVVFAKQIVSVVAMVPLPLTQDEARDPRASELYGQRYFVVEKPGLDVALMAGRTEDTHTDKDGLDTEDGVDTEDGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTQ1</accession>
    <name>A0A2G8RTQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_12767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTQ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTQ1"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL24880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="196" mass="21762" checksum="CD3A81F5C682E26A" modified="2018-01-31" version="1">MKLAKNHERKSVLSFEIQGTTVMGSNAQINKQLLIDVMRHADVDRLKEPLCPEPDVHILLPPLSKLRTVVERLRPLAEEGIHFRANHSGELQLSTSTENARLEIGWSGLTNPPMSRNSDGTQKTDDSEDKDPTEMHGILVSHKCLTKFLNCHAISSTTIACICANHCMILYVYIGDVSDAGGVLTFYIPAQFDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTT9</accession>
    <name>A0A2G8RTT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTT9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTT9"/>
    <dbReference type="OrthoDB" id="2802795at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="483" mass="50596" checksum="D0DF42534492524C" modified="2018-01-31" version="1">MIRPPTEPPELRIVEPAIPLFVPPLQTPTAPPPQSSTPKVKKPNFSFLPLLPVEDPSTLSAPVVQSAPTPPRRKINMNFLPVNAMPEPEPPSVLPHSPQDRGVGTQSESALLPSQTSFVSGPDPPSRSDAGQLNSESADYEVSSLTPTTSTSDKPSMSPPPLSLSLPATSFLPLAAESDTDTDTYTDTDGESDAPSNSTVASSVPSPPCEFEDGPELDDLKIGSYFPPVSLAHPLMDPSTPHLHALSHEEAIVLASSLSPEPGQTPPLSVLFPSPKRLNRILPPPLDPTVPSVISQSSTKSPAIFASLKSSAPLPDRPSITLPPGLVSGARTAESSLPTTPLSVGRILQKKLMLEALPSPALVPPSPFELEPHQRSGASPRFSQGVLPESAAADHDHHVLIEKLEGLRVAEAESLSDTPVSKAVPAVAADIPPATGGSPSPMLTLESMRVAWDANARQGLARAATRSGGVAVIAPSLSRRRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTW3</accession>
    <name>A0A2G8RTW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTW3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="466" mass="49402" checksum="492E0C25951AC905" modified="2018-01-31" version="1">MPAEMLADMLVEVSSIARGSSGPQSEHSLTINVHVPTAGTKAGDKLPVIAAGVFVCGQWIFGGGFVVGSSELFPGDPIVAHSVAMGQPVTYAAMNYRLGPLGFLLVRGKEVKEAGVGNLGLQDQREALRWIQKHIAAFRGDPEKVTLWGPSAGAISSALHMVTNHGNTEGLFRAAIMSAGSPLPTGDIEELQCGGTSDTLVCLRQVSGPADNLTAAAAALPNLFSYSGLATPWAPRADGQFLTAPLQHLVLAGQVADVPFITGGALDEGTIFATGSWNLTTEQEFHDYVHKYLFSSTPEALLEPLFSLYPADPAVGSPFMTGDDNQLAPMYKRMAAFQGDVTGNSPGLGYAHGRDILPAFMGAALADYIIQFVATLDPNGDGANGTTSAIYYWPKYDTKQWRVLETHDDGVAIGADTLCIEPMAALTAISLAYPMSLNVAGLVRDRMIYLMSWRGQNCQGRCFSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTX6</accession>
    <name>A0A2G8RTX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTX6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTX6"/>
    <dbReference type="OrthoDB" id="2800937at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01650">
        <property type="entry name" value="RT_nLTR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="398" mass="44609" checksum="D2252C0EB3FEF650" modified="2018-01-31" version="1">MASLDAALKECLQLGHHPAQWKFFTTITLRKPSYLIPKAYRPIALEDTSSKVVESVVARRLAALAEEHDLLPPNHFGGRPQRTTTDAVLHLVQRIKDSWRTGNIVTSVLYLDISSAFPSVNHRPLLHNLHKRSVPEPLVLWIANFLRERRTQLKFDDFTSQPLLADYRQRLSLGYIDDTAIVVTSPSVATNIRILSAIVPLLLNWSRMHACRFDIGKFQLVHHTRYEPCYVPLPLQIDGHTITPSESARYLGIIVDRRLRWHEHVEAAIAKGTAAVLSSPLIGRLAKPTFGLPHQFARRLFKAVVCPRLEYGLPVWYTPVCRWEGSHRATGSVGVARRIGKVQRLAGLMITGAFKSTANVFLDYHADLLSARVQTRRRTAISTTSCASANSAARACST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU76</accession>
    <name>A0A2G8RU76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU76"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU76"/>
    <dbReference type="OrthoDB" id="2728997at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27453" checksum="7747B90787C66F51" modified="2018-01-31" version="1">MEEVEEEGEAGGGGGDPGGGLPGGIPGRHGGGIPLPGGKGKVRPPDIFTGDHHKSQAFIDSLWLLFTGDPTRFTSDNVKITTALSYISGENVNYWVRNKIESAQYLGLGTWYHFVRDFTLVFAPLNEAENAILALEQLNLKSDSTIHEFNGKYNELIRKSRIFDDQARLSYYRNALPAWLRTKISTSCPVPKTIEQWIERATDIYEADAYDQAINRRRKGFGRFCRTPQKKVQQNQLEEAEETGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUL2</accession>
    <name>A0A2G8RUL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase TEL1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATM homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 16">DNA-damage checkpoint kinase TEL1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Serine/threonine-protein kinase tel1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Telomere length regulation protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSI_13095</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RUL2"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="21">
        <location>
            <begin position="1409"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="20">
        <location>
            <begin position="2117"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="22">
        <location>
            <begin position="2452"/>
            <end position="2484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PIL25206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2484" mass="279946" checksum="869DE0801D4214D1" modified="2018-01-31" version="1">MRRANVPAVSRAACHTAHTLLTYSKRLLSSQRVLLEIESFAKDLDVQGPAYPYDSVCDFMVLCLRVANQDVRLYRLQMEEKVLSWLTESWRIGSERRTSMPLHTTAHIHALLEGIVGASRRVRLQCGMMLPHCPIVDAVIEETQTKIIRDFQLHACLPPYRRPVPASESCSSIDGSQDDAGRTSLPFGDSADLTPPRGRERRISAFLLKSLEELTVTVSQRGPGYGFPTAERVRSSLDLAVTAFCFEASLVMNGTQSNRRVLQAACKLIGSIVPLLTDTRWKAEERRLILDALDPLARADEEGVQELEWEALVPPGERTGIRTQVLRKLLSTARTKPSETAHRRDLQRFVFRSADVQDAFVGLLEALRNVLRLAVGQSLDTGSQAMASVDDSDGFGPVRNAHAVTSLSTTRNAQQDEVHNSRIVDSCMTVLAVVPILQSSSGEPTRDRVLTDLVMNSEPHQFLALGPAYCEQVGRRTLNLSAATLNALLDKLLELSKVYSYQGNEETLLLVVNALDRTSHVWMDPTVATSGPGGRARTFSWETIDRLTQRSQRSWRVTDAIIRFLDRYLTKDPSQETWAMPVQDADGPEEDQFPAAVLPTLGNDDDIRIRFRIAATSPRLLTVGRLAQRDLMHEVYPNIQHNLSTHQENYESILTRLLCLGNIIISDASVRRGAYWHLLEVAFFSTMYLSHLKAVLWGVVERMGIETLSDLFNCYASQFAYSIRRGGIDLLKFPPELLGYRDRRECAEATFHSFTPTNLLAEGGAEEIEYGKELFVRHCQAVQKNEQAGLDECFVQLVACEIVYWLAPTPDLEAEAKLDDKLRAKTRYHKADPSFQERLKRDADAIVIAILKSFGDQDVSFSGRISDGIKSATNEDIVEAFESITRHRSLDTVESHEPNLPFYSTAVILRAIEWYRSRVNEADEPAVTYHVLHELFADIEASPLVNEQLRLLNAVSLWIACHHAHFKDECLLRTLTLRAVTMLAQVDLARGAQSLLEWCFSIYKVSPTKADYRLADVLIRISTIAHDFSQSRVDASVATLGMDLLTWAETQAEILRMNSLLKKQVLRALAAWPRELPDSLQLACEEVQFSDLTSVLVDHGVSASKFRLVRRIHNLAAQHEPDDFSKSDFWRLKGCIPPEKYLVDSDIDAFTSLLMLHHGQVDSIGSDQFERESVRVVHAKARDDSTSNSARKELPPCVPVSVARSAIVVSLRAMLDSSSAAQVHVAYKTLRTLMSVPCEEPYLNSSCSEDIRNELRYLKEYSKPLPEVSTLDLRGALMDDTMLQLAVDFDAWITRLTTILCNVLGTRDPFFSTLAPVLQSNRGFAEEVLPVLVHSLLQEEHRNHSYNTPGSVRSVLTEYFSAVLSFKDSTVPCHRAIISVILHLRRFHPSNKVKDALAHNKWLTLDFTTLGRSAIKCNAYTTALLFLELAAEYRPVENSSDESAREHILFEIYSHIDEPDGFYGIKTDDLPTFFVKRLRHENQWEKAFRYHGAMIESGSTGPSETDGVVHSMYALGFNQLALSTMQNFFADTNSTTESSALAYNLGWRAETWDLPENLGNDTSGATLYLALRAVYRERSTQTVTMTLRRAFVQEMNRLRDLGNENFTEIRQVTQNLMCLSQVRQWQGEEIQKALQSRRIDGAEWKPFTRIDPAFEFSNIEAIMATRISLVRSARQKEQRLQIGDLTSPFCDALLELEKASLLAQKLEQSFSPNVSQEFANVMWLTKEPKMAVQSLAALVSSHGMTNIMDDEHSKAQHAVLLAQLGTWSAEASVKKPSLIIDECFGPAVNLVARINTENFVSLDDGHATVFHQYAIFAERQYHSISKSPDALRWKIYVDRKREEIKQRQRRMTSVQGTPEYDTLKKEQSRAHQLLSQDIERSKEHLSQRTSFLASAVEMHSRCLAASDKFNEDSPIRLCSLWLANFDNDDPVLRFGEALDRVPSRKFVFLAHQLTARLSKSDRDQPTPNQEVLQTVIQRMGSEHPFHSLFPLYCLKGDRPPPKVSGISRRHSVRQGTPGASQLERVAAVSDVFDKLRSDPGAGERVKAVEHVCDASLEWAKYPIKHLFGKGKQTPRSLSVPEQVLIRKLKNVRVPVITATTPIDPTTEYRNCVWISYFDEVYTTAGGINLPKIIKCRGSDGKFYKQLYKGEGDDDLRQDAVMEQVFDLVNVVLRHDRETQKRKLGVRAYKVIPLASQAGVLEFVDNTTPLANWLKPAHIRYRPNDWSQDDVHKEMVGSDNKFSGQWRKEPQAVINRFDRVQQHFKPVMRHYFTEKHKTPMSWFAMRLHYARSVATNSIVGHILGLGDRHTSNILIDNKTGEVVHIDLGIAFEQGKLLPQPERVPFRLTADMVDGLGISGTQGVFHRCAEETLRVLRDGSETILTVLEVFRYDPLHSWTASEFKIKRAQATQPDETAQLTGEAFRFAVGIDMASGATDEAADRALSAVARKLDKTSSVEYTVNELITEASDSANLGLMYIGWAPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV14</accession>
    <name>A0A2G8RV14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV14"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="139" mass="15359" checksum="3C1D9003B0D006E7" modified="2018-01-31" version="1">MPPLRKIVKFEVLQIETGGQELYELVQINRLLEIARLQRQLAETSIERWVNSLKMVHGLADLLVLLGSAPLAHLEIISRDSDVRAHMWARVFRGFPSLVSLAASADGALFDGLHEASLTGPAEGPVACQGLMRIRISDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV88</accession>
    <name>A0A2G8RV88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV88"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013647907" description="Transporter" evidence="2">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34828" checksum="D635D01DF9562DB8" modified="2018-01-31" version="1">MLPQLLAVTVLAKAVALSAFAAGPAPGQIKNLVTFGDSYTDVDGHADGGIMWPVFASEDGNFGLFPFAKSGATCSNNLTDRPFPSVFESQLPTYFAEKANGSLTALKPEDTIYTLWIGTNDVGVGALLTGHQTPGVTVVDTVTCAVNWVQTMYNSGARNFIFQNMIPLETTPLYSADSYPNRYWTAQRNTTEWSVFMKELTTSGNAIARLELQLLAPTLHGAHIGFFDSHSLFADMFARPQLYLNGTAPLNVTGAVHSCVFQLNESTGDPGVCTDATGTDQDSFLWYDELHPSVQAERVVAKEISDAIHRRSEKWITWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVW7</accession>
    <name>A0A2G8RVW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVW7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVW7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="298" mass="34066" checksum="67770225F8D60474" modified="2018-01-31" version="1">MPRCDRCDRWFRTAQALEQHKDDSSMHHICYDCNKDFALNTALIQHFTQSPRHHYCRSCDEHFDDWDDLYDHYDEAHYYCRICNQVYESEPGLHEHRRIVHADEYCVPCKRMFRDTNALRHHQRSTLHQGRTIACPMRGCSRSFVSRAALVLHLESGGCPSRITRDMVNRIVAKLDKHGVLTDSARLLGSGSGGSGNGQETVTVTGAWATARAWNGARYECYLCHRTFAALPDLNQHLNSPAHASRAYRCPGAWRGCGATFRTLSGFCQHVESEQCGVHRFKRDRFIDGLPKGGKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW42</accession>
    <name>A0A2G8RW42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW42"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="291" mass="32681" checksum="A3705C51B54FADD2" modified="2018-01-31" version="1">MDPVLRPRSYQNSAAQIKALFPPASITLQNLVIRKTEKHLYEFLERVLVPGRLRGFATGPQWREDLPYVHQFLRSPAARNLLSISIDGIEDAYDQSLGATEASLVHETLGATLAQCMCAQYVHFGLIIDRETRNLWPDEGPLSESAPSTWCPLLANLPASLRALSLHVWILIYPGPPLTRGWARATRGWNSAARSLAAADRSLDPAGEGRRFRHLRSVELHVHFCYIETSGGRGDDAVEKRARRDIDSERAAMPLPRLKAAGLLREFRVNNMVHDPDHSGEFMADLYWPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWX4</accession>
    <name>A0A2G8RWX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWX4"/>
    <dbReference type="OrthoDB" id="10536597at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="204" mass="22398" checksum="1E293CF5B9F499EB" modified="2018-01-31" version="1">MSYPVNYANLLSVSSALWLGAGGIGKGSRHDSDPSAKVVKKIFQTLFKIPQPPIKIDTVPDTPPSPPPPNPPVRPALVRACTSATLLDTDFLSDALPPIVSPCIVEFRFKSSTDGPVVDRLRNHLSARPAPPVEDGNLGQEAPVVNVAAPPPKPKVRRGKKKRTTRKKRIVRWTADVIEREIQANRPVTGHERLERFRRLGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX71</accession>
    <name>A0A2G8RX71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX71"/>
    <dbReference type="OrthoDB" id="3235454at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="149" mass="17306" checksum="7D8706A02904D2C1" modified="2018-01-31" version="1">MTAVATQMQTSWEKKRREKEARFIHNAKQDLDKCLSERIEEYAAATAELNSAYEKFVLDYAQAEDRIRKLWLQLAHDQQKLLARIVDISKKRQKANEINDSEREKGQVKGLAIAKKAVEDIWLEDRREVQYAWPLPAISRSVHGTDGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXL4</accession>
    <name>A0A2G8RXL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_11812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXL4"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL26058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="40706" checksum="4E78D2E3441185C9" modified="2018-01-31" version="1">MTDHMMVVHFDPVHGWSPPEIQPYGPLAIDPASSCLQYATSVFEGMKVLLALAEIPTLSFTESHMAHTAYAGPDGKPRLFRPDLNMKRMETSVGRVALPSFDTDELLKLIQKLVTIDARWIPTVEGHSLYIRPTIIGTRDSLGVAASDRATLYVILCPTGPFFRTGARPISLLAVNEHVRSWPGGTGAYKLALNYAPTFRPQQHAAKLGYDQCLWLLGDTITEAGAMNFFVAVRRDDGGKEMLMGGGTDVDVITPPLDGTILPGITRASTLELVAAHPSRATLPGLSPDVRLHTVEGELTLPQLSTWAKEGRLLEAFTVGTAVVVAAVGRIGHNGTDIVLPPHEGALGPIARGLYERITDIQEGRFEWEGWSVACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY81</accession>
    <name>A0A2G8RY81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY81"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY81"/>
    <dbReference type="OrthoDB" id="3027208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="43"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="347" mass="39163" checksum="2E532F386A73B6CD" modified="2018-01-31" version="1">MTDDACRPLKRARVSDTDLSSSPSSASASHFQRQDPEFWLSDGNIILVAKNGTAFRVYRGLIAAQSTVFEDMFVSSTSGADELFDGCPVVQLTDSSEDLTHLLRVLLPKSERRYHRTERRTFDELSAVIRLAHKYHIQDVQDQALAFLQETVFPSSFARWYEPFTGTHVTAIQSIGVVNIARLTNTPSLLPHGFYFCTYLGGKLFDGWTREDGTVEQLSTDDLRRCFDGQRALALEANLIPGEIFTEAQMADCTSPARCQLTWQQTLRGIGTCREVNVDRRALDRWNPMITNMAKDEMGAPARICRVCEKELLRRERRQRYLIWKKLPEIFGVTVEGWGAGGDEAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYB2</accession>
    <name>A0A2G8RYB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYB2"/>
    <dbReference type="OrthoDB" id="2800059at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="36940" checksum="1608A5AF5C436031" modified="2018-01-31" version="1">MIPANDQANATMPADSTASASELQRHPEIWFDDGNIVVIADGTAFCVYCGLLAAQSTIFCDTFASSTPIPDEAFDGCPVVELSDSPHDLAHLLRVLLPKEKINFRSTTEDTAHTFDEVAAVIRLAHKYDIPQVLNQALATLQAHTFPTSFAAFSAPSGTPEIDLKPAHFIGVVNFAWLTDTPHMLPLALYRCCYLIDGWTHEDGTVEHLCPANLKRCMDARVALESERSFFLFHLLVHGKPSSAACDCPCRAECSASLRQLYECTMHVDSLAHLCELRGRTEFSQLFRHARPPAALLMPSMGLGCRAPGSERSEGRPVWGVRSGLAWEEREGAAEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYB9</accession>
    <name>A0A2G8RYB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYB9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYB9"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29858" checksum="E79E806F7D460B4B" modified="2018-01-31" version="1">MTQEDRPSKRSRTAADADADAHVETPLKHHEEFWLDDGNIVLVARQVGFRVYRGLLVTQSTVFADMCASSSPTADETIDGCPVVHVSDSPEDLAHLLRVLLPTTQRRFHRERDTAERTFDEVYAVITLAHKYHIEDVQRQALYSLREYTFNDNFEVWKGERQEVMKVDGACAIGAVHLARLLDVPQMLPIALYKCLNLGPNILDGWTRSDGSVERLSQDDIKRCISAQRSLSRDRVAYTYWTLYPQASTGTPRSFFQMLVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYS7</accession>
    <name>A0A2G8RYS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SLM1/RGC1-like PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYS7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYS7"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF1">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLM1/RGC1-like PH" evidence="2">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="326" mass="35278" checksum="29D49605022A9F2A" modified="2018-01-31" version="1">MAALPPDREWISFAAREDHLVDPETPLRDPQVINYPSKDDPSVHPVHDGLLERKKRYTRAYKESYYVLTAAGFLHEYASSDPALAPSRCLAVPADVHARATVDGEREEPQVPHRGAQGRDGRRKLGLVPEHERLADRARARLWARVGVPRALARRHDGVVERHPDALRAVPGRERADGAVGPVHAAVRAVGYTSEEEGEESEEEGSSVEEERDEEDGAVYVEARDHEEAGPPEYTHGPAPQGMEYGAHGYPVDKKTNGVQGEGGANAARRLSRRQEKAPEGRAGHAAAPSGSGPVADEEGTGAAEPEAEHAAAAPAGNESRFTEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZQ7</accession>
    <name>A0A2G8RZQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZQ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZQ7"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013567182" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="104"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="414" mass="43665" checksum="A221445A352DE1E3" modified="2018-01-31" version="1">MGTVSNITSVLVALAAWAYASTASAFASANDTIPAQAVLVDRLAYTVLGVNGAFRTSAFTELFNPTNATPPFFQVFDPAFLAILGPAATIRSIAANPDFAFAHEAPIWLPEADEVYFASLDGSPLGHSDIDHNNQVSKISLGDVAQAIDAAGPGVSAVNVGFTKIESLPEEVQMTNGGTGPLHGKLVFVNSGRGPLPPSLVLVDPADPANTTVLLDNFFGRQFNSLNDVKIHPKTGKLFFTDVTHGHLSDFRPAPLLPNQVYRFDPATGSVRVVAADFDKCNGIAFSPDGKTAFVTDTGVFQGYQSAVDQTATSTIYAYDIDPKTDTFTNRRVFAYIDTGAPDGIQLDAAGNVYAGCGDGVQVWNPEGTLIGKFFLATTAANLVFAGDGRLVILAETAVYLAEIAAKFNKVSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0C4</accession>
    <name>A0A2G8S0C4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10355</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0C4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0C4"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008854">
        <property type="entry name" value="TPMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32183:SF6">
        <property type="entry name" value="CYSTEINE SULFINATE DESULFINASE_CYSTEINE DESULFURASE AND RELATED ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05724">
        <property type="entry name" value="TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51585">
        <property type="entry name" value="SAM_MT_TPMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24654" checksum="10B5E1F153E2F04B" modified="2018-01-31" version="1">MAQAREAQMVQLQEMINEHEYKGWDFAWKSDVTPWDAGSFQPALKEILDDGIVPSSLIPADGRALVPGCGRGYDAIYIAKALGLETLGTDISQTAVEAAEAYRASLKEDVDVRFEVSDFFSIDGIQFDLIYDYTFFVAISPSRRADWGRQMKKLVKPGGFLITLVFPIDGDSGTGPPFYVRAEHYEEVLGEGWTVVADRVPEISLESHKGRERMIVRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0V5</accession>
    <name>A0A2G8S0V5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_10547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0V5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0V5"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL27399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="498" mass="53719" checksum="71FAAB205D54DE81" modified="2018-01-31" version="1">MVNITYDASESIQYQDPSTGTLTVYSPGDIAWVLASTALVWIMIPGVGFFYSGLLRRKNALSMIWASMMTLAVVSFQWFFWGFSLAFSDTASAYIGDLRYFGLKGVLAQPSIGSVKVPALVFCVFQLMFAAITPMIAIGAIAERGRLGPIMVFVFIWTTIVYDPIACWTWNSNGWSFKLGGLDFAGGTPVHISSGTAALAISIYLGKRRGYGTERLAYKPHNTTYVVLGTIFLWFGWFGFNGGSALAANLRATQACIVTNLAASVGGMTWMLWDYRLEKKWSAVGFCSGAIAGLVAITPGSGFVGSPAAVLFGFMAGTLCNFATQLKFVFHYDDCLDIFASHAIGGVIGNVLTGLFAQSSIVTFDGDLAPIAGGWLDHHYIQLGYQIADSVSGMAYSFVMTTIILWILHFIPGMRLRASEEAEILGIDDAEMGEFAYDYVGIDLGTAGGHDYHDDHHTHGELNATTGGREPRHAALKQDSASSDAEHEKNTSSASATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0Y4</accession>
    <name>A0A2G8S0Y4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_10577</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0Y4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0Y4"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12215">
        <property type="entry name" value="ChiC_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.20">
        <property type="entry name" value="Carbohydrate-binding module superfamily 5/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="Carbohydrate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013768938" description="chitinase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="55"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="425"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="447"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL27429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="536" mass="57035" checksum="731423A63DFD77CD" modified="2018-01-31" version="1">MALSAAFKRVLFIAAVALAAVADVQATQVMRRPAAYKDAPNNAAQSVHARATSGKVNAAYFTNWGIYSGYNFPPTSIVPGPLTHILYAFADVSADTGGVALTDSWADEQIHYPGDSWDDTGNNLYGCLKQLYLLKLAHRNLKTLLSVGGWTYSQAGHFNFITDDTKRQQFVTSAVQLVEDYGFDGIDLDFEYPSTDALGSGFSSLITELRTAFDALATRKGDTVPYQITIATSAGLANYENLKFSEMDSKLSFWNLMAYDYAGSWLTWSDNQANLYGGARTNVSTDKAVKDYVSRGATISKINMGIPLYGRAFEQTAGLGQPYNGIGPGTVEAGVYSYKFLPLAGATVIENTTDVSSYSYDSSTQELVSYDTPDIAKLKAQYVESQGLAGSMFWDLSTDKTGDDSLVETTANVYGSLDQTQNHISYPDSKWDNIKNNMGQGTGGGSTTTTSPGSTSTSSTPTSTSTTSVTTTSTSATTTPTGGSGACSGVAAWSSQTVYVGGQSATYNGHLWTASWWTEGDVPGGAAGVWVDKGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S102</accession>
    <name>A0A2G8S102_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S102"/>
    <dbReference type="STRING" id="1077348.A0A2G8S102"/>
    <dbReference type="OrthoDB" id="3267993at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="111" mass="11730" checksum="7C2C24D92CD3B346" modified="2018-01-31" version="1">MPSQTQKSDSSASSTKSIPPSQLIALPSLACSLSSLPQAKSIDTLPLHPTMLAQRNAESQAKLQKALSRSSANATLPPVYAAPRAQPVQYSASSNSPPLMMRKPAKTKMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S116</accession>
    <name>A0A2G8S116_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S116"/>
    <dbReference type="STRING" id="1077348.A0A2G8S116"/>
    <dbReference type="OrthoDB" id="1065058at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="450" mass="47822" checksum="5C1BB2AD06A54E1E" modified="2018-01-31" version="1">MPPPRSAAPSETPTRYTRVSTRSTAAGSSSTGIVKPRSFSTASLASNVSGVTTIVPDRRSINGSPKDPGSAARSPNATPVPPSQLPQTLARRLSSATKAPRRVSMPTPPTSFLDPSLSTSTMSSSLSKSTTTPSRQNSIPMPRKGPAAPSVAASRRSSVRSAAISLYTSESDTRVNSKMVPATPRTRALSTPFAQANAKANAKSPAKSPVRSPGSAIVKALPAPPEEPRATMVTPKSSPSKPQRTPSKPSPKVTPNKAVTPAKASTPGRTVKNSPSVHARKVSGSMDSPSIMLTSEDEPFWEADGDDMTLEMITDVNDGEVDEDMQGALDGVHSLHMRKLLHYKRLLERAQASSAAQLHALQAEVRMLRERERQQEMGGTVLDPDDDSYCVCGGKKKKGYWSGYRGSEDDGISGEVDLATVLRGDGGGGFNEIEVRRVVRGLSRDDRMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S168</accession>
    <name>A0A2G8S168_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_10445</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S168"/>
    <dbReference type="STRING" id="1077348.A0A2G8S168"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="43"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="215"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="402"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="797"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL27298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117531" checksum="798547DD24ACE4C9" modified="2018-01-31" version="1">MPSWSHVPAAGAVPAYRMFTGNLEKPELDDRQYRVLQLQNGLRVVLIHDPDADKAAACLALSVGNMYDPNDAQGMAHYCEHMIMKGSEPYPDEGDFASFINANGGAKNGVTGPMSTHYFFSINPTQLQGGLDRLAAFFYAPLFTESLAAREINAVDSEFKRNLQNDVRRLLQIRKHLGLPGHPIRNFGTGNYQSLTDMGRKGIPDEDESTVLLETRRRVAEWWEHQYCAGRMVLAVIGKEPLESLTSLLVPIFSKIANRGYEPNPSVKEPFWGSEQNGTVVFVETVKDFYAFTLEFELPDLRAYATSKPTSFLAHFLGHEGYGSIYAYLKKQGWLLGLTASISGHTRASQTFAVSGNLTLQGYLHYDAVLETVFKYISFLRRSFPLPDYHYAEVASMAETRFRFMPKEQPHSYAVKLARVASEPYSTECLISGPSLYRGDSDAIQKELLDSFTPERARVFLQAKVHREEVVGKDVQWETEKWYGTQYAVRKMDEALLERLRNANGNPELALPPMNRFIPTDLSVDKVEVAEPAKYPVLVKRTELSQLWHKKDDQFWMPKAHVRIFVKSPLAYVTPRHALLTRLLVDHIDDALAEITYDASLADSNYFVSAGVDGMYVGVAGYNDKLDVLLRIVLEKLRDLVVLPDRLRVLKEKLKRQYDNFYLGQPSSLANTFATWYLRPRTWTPAMKLMELPSITEAEIERHRDALLSKVAIDVLVTGNFTRERSLEFLSLTEECLKPRPLLPSEIPQLRSLILPPGSNVVTRKRLANAKEVNSALSYFCQFGESSDIKLRNIAALLHQLIREPCFTQLRTKEQLGYVVIVATWSVAHSTHGLGIRVQSTRAPWHCEARVDAFLEAFAARLAALSDAEFAMHKDGLVVKKLERAKNLGEETSRFWGRIRAGHCDFLRHEKDAEVIRALTLAEVVDAYNRLVRPSTGAHTRRKLSVQLVSQQLKEDPPLSPFAPTDIDAKEAVAVAAPLQVFLDTQEVLGVLDRKAEEQETAFKARLGCAPSTTPIVSAAFGEYAGPFEIGSPSGDAVGDEKVLAGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2P2</accession>
    <name>A0A2G8S2P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2P2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="16962" checksum="3B5B9895EEC155E3" modified="2018-01-31" version="1">MAFDPVHGSTRLAIAPCRSPVGLSVVDVETGCVLAQMEGQLGKNMVMHDFLFSPDGTLVLGVCSIYDGGVCLWEAATGIRLFMFPQYVDDFRKAWFSPCGRDGSGGCTGLEIRLYTYSETMPSRSSNNGKAKIRRRNRRVSEEGTRAATVADTAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2W1</accession>
    <name>A0A2G8S2W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2W1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="203" mass="22504" checksum="D96FD872156645C8" modified="2018-01-31" version="1">MPSSCPEADTQQRKVAGGPFSCGSGSSINVVYDRSEELRFWTTTSARSMTCSPSIAASSLPCDRRAEARHLRRSMSGKRQPDRASYQAPRPPGRSQVADRRGRVVHPNHPARFPSSSDSLTWKPPTPLSALPKDSNTPLHRLIPKSLSWRQARSAVREQGRSRFVVDNDLRPLNQFWDTGRATAVRDATALIIDPRDQDTAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2Y3</accession>
    <name>A0A2G8S2Y3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2Y3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="144" mass="15646" checksum="95372A961D4AE39D" modified="2018-01-31" version="1">MKSTTSKHLQDRRRSGPAGVDCIGDFATAERGYLLVFSHVIVRNNRSLSALLHSLRMHCARSIGFGGPLSTPLAEVTHDEVLEIFDRALGRDTSGDGPRPFDPPCLRRTTGIGSAPDAEGGTCEGSGLKTWKRKRDSVTTRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3D7</accession>
    <name>A0A2G8S3D7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3D7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3D7"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="239" mass="26519" checksum="93E1AD7CB5CC0A67" modified="2018-01-31" version="1">MVQNGQITFYTHMYSPNCHRVHIALEEVKADYTPVTVNLMEKPEWYNQKVNPITGKIPAITYGGPKHAPEVPSGEATSLIESMVIVEFLGELFPAANLVPRDPLLRAKARIFTSVVETKLLEGLRSHFFMGGPASELIAAFEALQALLPPAGGFAVGEWSTADIAAAPYLVRILMLLKHDIGKYPVGEGKKTMEVLRGPKFARIMQYVEDAKAWPSFRATWDEAATLEIWKTNPAIQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4L0</accession>
    <name>A0A2G8S4L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4L0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4L0"/>
    <dbReference type="OrthoDB" id="2793280at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="45735" checksum="391FFE86B8D54866" modified="2018-01-31" version="1">MNPRDPLSVPTPREILFRGWTVLIKHPGLDVRLLKFPALSADPTGRCGLFCPLVLNACRVLTNNKAEYGADFLATDIQGHNRIRIDDTPLDVDCYYFLGPLELEANRNYPIVKSFCAFIFPSSLPDDWCVIADARQRPIPVLGRAPPASAMSYEVKTRDGRCVITHYCDSTQCAYLIPKAEGVWFASNSMSTFASDNSEVGVDDRGNGILLRADVQLCMDAHGFVFYPADAHSFIAYFLSHDYSDFPELFHRRPATIHPDVPVQFLYARFAYTSINLLLSNDLDAIEEPPRYKAVKARNDLEKAKRKAIQTQTALGAMHESGRNEDDGMSDGSGDLDTSEKADGADMPELPEVEDPPETQTACHVETPHMLRLKSEYIRKNPQVWQTSTTPADAMREDKEGYYATLLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4N8</accession>
    <name>A0A2G8S4N8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08749</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4N8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4N8"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF5">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="3">
        <location>
            <begin position="150"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38460" checksum="7FCA05EDCB64B95A" modified="2018-01-31" version="1">MPAKGLAILGAGIFAKEAHLPSLAKLGDVFSLKAVYSRSNKSASAFAKDAKEVLQLQEPPDVYHDEDSAASLDVLLARSDVDAVIVVLPITVQPTVILKALAAGKHVLSEKPVAPDVSRGRALIQEYETKYKPQGLVWRVAENFEAEPGYLAARRIVQEGKLGKITYFSARSYNWIDENSKWYNTPWRTVPDHTIAALRMILDSPFTTLSAHASLAKDILPPHDTINAIARVANGAHGIIELSWGTPVPTRATDAHNSISVTGTDGWLEVTRAPGVFRITVKTATRDEKGKRVGEQTEVIEEKEVGVQFEIAGFLEALDGKDDGLDGPRGTLVDVAFIEAALNSGGAPVDVGKLAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S523</accession>
    <name>A0A2G8S523_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S523"/>
    <dbReference type="STRING" id="1077348.A0A2G8S523"/>
    <dbReference type="OrthoDB" id="3784821at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="68" mass="7735" checksum="3F6956A4AF1320E8" modified="2018-01-31" version="1">MAPKLTPQAQRWRTIIFTLPIMGVTSFVLYKRLVLGEPRRTLPTDLEKHGHEKVVDIYTAGGEGKESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S544</accession>
    <name>A0A2G8S544_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08936</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S544"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="67"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="547" mass="61366" checksum="0E527392257B2A8C" modified="2018-01-31" version="1">MSKSRHAQGHGRQSRMAKCARKTDDGLYLRKDAEDIEFESMDRRYAFNVDVLETDTSDPRGFTYQNRVFKIGDDVILNSKFDDTNDIWLGQINQIRTSKDKTKTLAKVRWYWSRNDVATIMKSFDHTKCSPYERILSDDYDYVSPYAFQARAHVYEYHEDDLNPPPIGPTSFFIRTTLLHRKKQIKPPLGHDTCHCKEAYNPYPAPVLTNPDDMTSSPSEPPDTMHFCPSVNCRKWFHARCLALMQNLDTTSHPMTRAIRLLANDPDSQAPFVMFGHFAGPESREIVPDSTQQMTVNEALEFWTRERTILAHLPPALLAIAQAPIVRRSGVPGGWAIGNVADVVLARRFVYAALEHDGAPERSAKFLELLRRDAARWEDVIWLERRRQGGPSHGDVETMDVDMDSGADTQRADLPVELEAKGLGRWGSSTRTAAATASATPMEVWGGLWDGVNLQEDSDCGEEEDGGAEETLTASGSPGKGKSRSADREPDEISALEALCEDLGQFELLASPYGPYWERRGREFEEAAAAGLLDGPDFVCPQCRSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S652</accession>
    <name>A0A2G8S652_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="2 17">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_09290</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="2 17"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S652"/>
    <dbReference type="STRING" id="1077348.A0A2G8S652"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 17" id="KW-0288">FMN</keyword>
    <keyword evidence="16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="16 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL29241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="679" mass="75132" checksum="CD421ADD4EC29807" modified="2018-01-31" version="1">MATVTLPPGTAPVKPEFLLSFQARDIPDDDAAEGSASHTNGRLDAGPQGAEEPGKRLSGAQRKKLAKEERKQKRGANKGRRFQKVRDELELCFRVASGKKCDFGAECKFTHDVSAYLAAKPRDIYFPSTSEFTDEPPFVRLPDVEMEEGDAPKTSLDPNTTCPLFQKTGECKHGFKCRFLGSHSRIQEGGELELLVDEKKKAHVAASETEVNFIDGDTLRKIRTKKYPHPIADAYLQEIKNNAEGENNQAESAPPAAIRAEPEYASVVIAEEPTNDSAIVNPAPVADGAVDKSQDDTPDVPTRVSEKKRLHWKGKTYLAPLTTVGNLPFRRLCVDYGADITCGEMGLAMSFLQGSKEEWSLVRRHPSEGIFGMQIAGSKPQLLVPAAEIIGRECAGNLDFVDLNCGCPIDLVYKTGSGSALLDAAGRLGKIVVGMNKALGDIPVTVKLRTGIKDGRNNVHKLMPRIAPEWGGSAITLHGRTRQQRYTKLADWDYIKQSVQAVRAREEEEDLAPVPIFGGGDCFSSEDYWHKIDNYDVDGIMIGRGALIKPWIFTEIKERREWDISARERLEIIRKYAEYGLNHFGSDTAGVNTTRRYLCEALSFQYRYIPIGLLETLPAKINERAPSFRGRDELETVLASADSRDWVKISEMFLGPAPESWAFTPKHKSNAYGSEESQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6A0</accession>
    <name>A0A2G8S6A0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6A0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6A0"/>
    <dbReference type="OrthoDB" id="2755864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="3">
        <location>
            <begin position="407"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="592" mass="65360" checksum="74CD6BA34F26981A" modified="2018-01-31" version="1">MADPGEDMQEIKFFLQHYKEECGRLSRENQQLRDENVQVKARNAYLEQKNDKQAQLLRQLTTTGSSEGGPSGTLPDPSPVVPPSNVAMTPPSSHVPSKLHTPPLSSAGSTHDPLVIHDSDENIGVENLPNIQNIHPCPIPAGPSKRKSSPVSPERKHIPDLMFTPTSPSKDKGKQPAFKKRKCDVFVLVPPDRKHSVKASPTSAKSGIKRASSSPSKTRFDDPWDYSSDSSLTSLSDDDDDDLRPPSRHADVSKARTVSAGPSRATERPKSPDRELTYFDPPMELDDVERGDPTYVPSRRASPVPPPSTKRASRTHSSKGEAQPKLPKLFTAVRSATISDKTSPTHPEVGPSDPRQPSPTSPLQRRVTLHVSPPSSSSASAPAPHDHLAGLTRFAVHPYNPALLQSTLSRKRFSELLGGNTMRMCVPLGARNFLFPTLKQNPRLPASPGLPGLLFRANVEAEWRGDVQTVFVGVRGAEYRYVGEYRLTRGEPLGVEEYRALGAPMRRKWANGVVKKSKFKDIRVRIRARREHGREATVEEVAVAVADKDDKCEVSEENVMQAYQSGQERLLVWRMQCVGFDEAFLADLVRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6E3</accession>
    <name>A0A2G8S6E3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6E3"/>
    <dbReference type="OrthoDB" id="10434748at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013681433" description="Transporter" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13691" checksum="6FF83600603E8AC9" modified="2018-01-31" version="1">MQFSLLVAFTAVLGAIGAMDSTTVYSPSSGSTLPETFYFKYINTNRTVSDPKYATSLQVSLYTDKDGFKLIGQPAFSDSDPTTSEAVLRADPATFPKGEYQLSVNEVGPSGTVFSDMFPVTLCSPDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7I6</accession>
    <name>A0A2G8S7I6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7I6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7I6"/>
    <dbReference type="OrthoDB" id="2756395at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="81" mass="9206" checksum="919FB395F35A4346" modified="2018-01-31" version="1">MSVKPWDIYVEELLPIGYGHPLWMPEPDSNGRQVFIGDVGWLKAGAFRALFNSMEDADHPTNQEKKVPVGFQMFRPSDLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7N9</accession>
    <name>A0A2G8S7N9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)</fullName>
            <ecNumber evidence="5">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_08008</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7N9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7N9"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 12" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="13">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL29802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="36964" checksum="F69F08DE2F5783F6" modified="2018-01-31" version="1">MPVKVGINGWMLRENQGRIGRIVLRNALRHNDVDVVAVNDPFITLDYMVYMFKYDSVHGRYEGTVEEKEGKLWVDGKPIAVFAEKDPTMIKWASVGAEYIVESTGVFTTIEKASAHLKGGAKKVIISAPSADAPMYVCGVNLDTYNPQDKIISNASCTTNCVATLAKVIHDKFGIVEGLMSTVHATTATQRTVDGPSMKDWRGGRAVGPNIIPSSTGAAKAVGKVIPSLAGKLTGTSFRVPTLDVSAVDLVVRLARSATYDEIKQAVRDAAAEGPLKGVIGYTEDKVVSSDFVGADASAVFDAEAGIALNPQFVKLVAWYDNEWGYSHRVCDLVAYAAKMDGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7R9</accession>
    <name>A0A2G8S7R9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7R9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7R9"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="66" mass="7073" checksum="CB664F2601689ECE" modified="2018-01-31" version="1">MYLDVLPAGPDGAKAFRGKPLDPTTLEKMSAEQLGQLYEVMHVTKDVWKPVSPEQDGKAPGSDGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7V1</accession>
    <name>A0A2G8S7V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7V1"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="389" mass="43881" checksum="DB586692E6AEF591" modified="2018-01-31" version="1">MAGGLPVVLHNFSSFKLSDLARLLGSRSFQYAPKVVKYVVALIFLINIRSWPLYWHWYIWKPVFQYRGRYYLHSLRHLLSPVHVRQQKKLEWLESLSPVGKNPFELTGIYRVWAGPDECDFNLHLSNSSYPKRLDAGRFRFGLLLSPTFFRSGGWMGLGATHFTFLREIPLFSHYELRSTLMSWDNKWIYVATRYVTKPKKGKAKLRKAISSPKEPSAADGVGPIPTLRTANGVISGTGTPANGTNPDLAAIAAQIIDRPEPDGATVHCLAIAECVGKIGRITVPPALILAADGFARAPESLDGVAQPWSHANPPPHWETVRELRGQAHLEHAGSLKRLQAFYTGGWRDVPEDKRWWEQALGGEIEERRLRGLRCMQALRRGIEEARTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Y3</accession>
    <name>A0A2G8S7Y3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Y3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="104" mass="11567" checksum="E547F9D97F0143FE" modified="2018-01-31" version="1">MSTCSAPWSADARTVIPYPSRRPADATTRHDSGRRKELRGFPCGRRPCRVFQARHPTPLCRSQERGMEDGGTVSDLGLASARNGRFLLFAHATTRWSCSGHMHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S854</accession>
    <name>A0A2G8S854_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S854"/>
    <dbReference type="STRING" id="1077348.A0A2G8S854"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL29708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="741" mass="83209" checksum="0550E2F5D9276085" modified="2018-01-31" version="1">MTMSPVTGFEENPQESRTFARQGELPKLPVPPLQETCRRYLRALEGLQDPKEHEETKRAVDDFLQHDGPRVQERLKEYAKGKARYESYLSHSDPVVLALNPFFVLENDPTPDRGQQLPRAASLIVSSLGFIHDLRAGTLEPDHMRGTPLDMDQYTRLFGTARIPTEKGCKMEPHGDSRHVVILRRGQFYWFDVLDSENRPVMTEREILRNLQAIVSDADQMPIHEVARNSIGVLSTENRRIWSSLRRALISNKNNESCLEVVDNALFVVCLDDTAPENLADLCANFLCGTYDLKNGVQVGTCTNRWYDKLQIIVCADGAAGINFEHTGVDGHTVLRFAADIFTEGLMLLARSINPSAPTLFHAPLSPYAKSYKSPRGQASQPFQAYHIDTAPKKLEWTLYPELRAGIRFAETRLSDLICQNDCQALEFKAYGKNFITSHGFSPDAFVQMAFQAAYFGLYGRIECTYEPAMTKAFLHGRTEAIRTVQPHTVEFLKSFFSEAPNAQKVALLRKACQGHVSLTKECSKGLGQDRHLYALYCLLQREREVAPVIDEDERPTSPESVTSSGSSAGRDRPPLPAIFTDNGWHILNRSILSTSNCGNPALRLFGFGPVTAEGYGIGYIIKDEGISICASSKHLQTRRFLDTLQSYLVDIQRILIQLHLSANQRPEPFVDHQGVLRDSKTGRPINGHRHGNSIDVGSLDEDNMMMGYSFFDSGDIEMLGRKKNRPSFYNTGKIIPLAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8D0</accession>
    <name>A0A2G8S8D0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8D0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8D0"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="351"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="45532" checksum="8D3757E1BE09C67F" modified="2018-01-31" version="1">MLEEGEIESITGSGSPYGLVDLPKVDTTGVTYSPAIEWPAAGSGDTESTPELLPYDDTTVHEPTANTPAPSVSLRLLVQQTTILRKNQKIALLDGYLQTEIGRDIAAPGSDIPRIRLKEMEVSKLHATIYWDQDRTQWSIVDMGSKHGTFIQSSAAPPPGTSSASGLDEKGSRLSAPRVASMPRALHHMDRLTIGRTTFTVHIHEGRTPCAACSPQGGEEIPLFLHRAVGTAGAVAGSNSSNKRKLDDVSPANTSDPTATRGRDPRKALAILKRTLLSSKNPAPAPPGSGSRSQYVDRSARRRALHPDMHSAATMPGSASADRSTVSLSTAPSPSASAPTTPPPPSGPLSATNIGHRLLLKQGWQPGTALGEGSGDSEGLVAPLDPPSTVGRAGIGVPARLGSGIPTVMHGGDWRDAGKRRRWEETGGGRDGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8J7</accession>
    <name>A0A2G8S8J7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8J7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8J7"/>
    <dbReference type="OrthoDB" id="2748713at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="714"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="803"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="949"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1070" mass="118721" checksum="2756CF33D12A112E" modified="2018-01-31" version="1">MICVYYANSSVNSRFPGIIEQVLPRGVMQTLEKLELDKFAIDPHDIQHQINLPMASIPTTSVFNMARYPAVRSLSVGSFEGKPLLDHLQHLFPALDGTLHFGWFDMRYREDSYAGIRDINQRSQESDRDGSDSPLRGWKKLDRIICSASTLYVLGLRCPIRLAMINCEGVEKYRYAADALRENPVARLKLTLYHEPGMFDGLFSPELAETLKHLTLCLLYSNNYPLDTDAAPRLQWDTLLAMLVSAIQPLKGLTHLRVVVGASVFVHKEASWPFAPWEEYAHSLRGSRFDYQGTAAALTCALPSLHYVLLTTGGFLSNWDEEGGRWKPYERWYISRAWRVGTPGNEGVPDGERKLVELHGDVAETIIRKEELVLSRSDEHRMVVFHTLPIEILEAIIDQTSDHAESLRRLSLTCKDFLPRARYHLFSTICIRNLQQMEASREFFDSHPWIVRLVQQVTLSVAVGDLDDESALNNPNIRVLDVVPVHLLSKLPSLRSWRMKTVPHLPSQVSLSLHRYTLSSYKKHGDRIKDLGLEMIPFDDILDFVGLISAFQGLDSLTCESLRFRTPRARDFQDQSDKLVGSLKIKRLLCSSVSADRYGLDRSICQAIRCATSILDHVGSREHLTDVCVVFEVSAIGRLGFCLSPAGTSWKECKALEDALLAFPYGHILLKDFPKKYRAGRVEFWAPAIERAFPRLAKRGLLTFPSTKADWSGSPGHELPVQCICASYDNRHVVTASGDGTIIVWDHERGTIAHEWLPHGGHGVLDLALSPHSPRLVSASGGGSERLAVWDFGLNGTQNVATLEGHTETVTACAWSPDGTLIASASGDGTVRIWDALTFEQRGLLDDSEAVSDPRSLQFSPDSRHLAWISKSPTNDYTCVLWQPLESDERQPMHLLSHPTLHTVPVNALAFDPHSMRLATAHGSQSSRTPEECVVRIWDVVSGAALAVLSGHARQVNDVVFSPGAGSLVLSAASDGTVRLWDAALGVLTVALDIIPGTSVLKACFSPDGEFIATATSNLKRGPVIVWRTRDGACMGLLAGHRLRVHHMAFSPNGEFLTTGDVQGVAIAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8S5</accession>
    <name>A0A2G8S8S5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8S5"/>
    <dbReference type="OrthoDB" id="2765179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="349" mass="38669" checksum="BF8CDB2288F64A57" modified="2018-01-31" version="1">MPPVPALGEQTPSFQTLVAAVSRSIQDDERSVSLAVIDAESEDMSSEDEKALVDTLKKWKDGVLRMPEVFEVLSKTNGHTEMGGYHSTHSLPADGLTGATEWKTWFITNFEKLNAKVDLTPTTQERVSAGASASTQTTVSGGNGTSRNRAGVKRQLSRSSATRRMNERPRSRKAPASAPQDLGGDVDGSPSRDWCHVSDSPAPRVASVRQRRSRRVTNTKGNKTIPNWTRVLSRAGDHSCPVTLEDLRAMARYLFEKGDDDPDTLRRYNFARWREFAARPENRKRTLAGWACIAPLSRKHAADIERYLKEYQRDAEDARSTRMVVEASSQRTHVLGGENLRESAASSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S905</accession>
    <name>A0A2G8S905_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S905"/>
    <dbReference type="STRING" id="1077348.A0A2G8S905"/>
    <dbReference type="OrthoDB" id="3265591at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="412" mass="46231" checksum="0096BA9441499861" modified="2018-01-31" version="1">MDDLQPTVLALVAVVIVIYAVRWYTDPRLQGDASLQYPDSAFKIATLDRWLVVFSGRRMVEELRKRPDDELSGPHGTWKDRYHTDIAREKLLKKLYSVLPDAIDEIFVAIKDNVPTQDKEWTRIEVMPAVAQILARASNRIFVGLPLCRDEAYLQLVLVFPGSLVKEAGILRRVPNVLKRALEEFGEDWDNKPNDALQWIVEKAIPRGETASTITQRLFVFNFAAIGTSSNIMAHALYRLAENPDLVGALREEVQACISDDGWTGTALGRMWKLDSLLRETMLTMTRKALKDVTLHDGTRVPAGTLLSANAYPLHHDAAPLADSDARADTFDPLRYARMRSGAGQSLRHQLTSTSPEYIPFGHGPGRFFAANILKATLARILLDYDVKLAPGPRRLRFADRHAAHADWSCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA27</accession>
    <name>A0A2G8SA27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA27"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA27"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="487" mass="55166" checksum="42D5466704462CC2" modified="2018-01-31" version="1">MASVADAIKHWASAHVWSLQTIAEEIPTPTTQTTRAANTFELAKCGIARRAEGDFMDDARPALEAVCRNFTAVMRTRLPEDSEERQAFAGFIPAVFHFQPTGMVSYHKYPIYRLRAHGSGPSYEHPCTEDERALFNDVLLVCAKYMNRGLVLRAPGGDYNQPLPEVGIYVRVKKSWAWIRWLDWEWDAPGRSGDGATPKSVAGTLRRYYTFLARRNFDGNLFDASKHMCIRSSGEEAAALGYLSTASLAQALSLWVNFHRWSLRTILEASSHTGGGVDYQLENQRVVVFVLLPRHLETGKPSTSADAFVLEQGGIVFKDERSFLAAQWPRLEWTCKIMANAMWMTLSATERHAFAGFMPVAFHFKATRLVAFHQYPLYRLTAHECGPSYDHPRITEDEKVFSDVASICGLLINRGVVVRAPRDDEPVLEAEVLVRSRKHWKWSPADSKWDTQDVAFDAPDPSCYHSGLPPTELYRRYHKSLTQRNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA38</accession>
    <name>A0A2G8SA38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA38"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA38"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL30630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="21254" checksum="8D1FA157C19C157E" modified="2018-01-31" version="1">MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDDPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVKEKWFPEVHHHCPGVPCLIVGTQIDLRDDPQVLEKLARQKQRPVTSEQGERLARELGAVKYVECSALTQKGLKNVFDEAIVAALEPPVVKKKNKCIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAC1</accession>
    <name>A0A2G8SAC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAC1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="151" mass="16804" checksum="6F7830556E09B12B" modified="2018-01-31" version="1">MSFMYASSSSFLSALRRSFASLSIRFCSSFSVCEWNDRTALPRRVMRSCAERPTAMTSRPCAQMTPSCSMCFCFARRSRSARCLRSAISVERMSRSCTLRVLRKSERLRGSSVPCIRRSATEARSCRCLSTTRSAFSSIRARSLPCVAGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB64</accession>
    <name>A0A2G8SB64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL30991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB64"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB64"/>
    <dbReference type="OrthoDB" id="2753634at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="112" mass="13097" checksum="339F45A266898C37" modified="2018-01-31" version="1">MFRPLSPKIRNACAKARHDGFHWLWVDTCCIDKTNSSELSEAINSMYTWYQHATMCYALLHDVPNLKDEDPRKPASAFRRSKWFKRGWTLQELIAHPTVIFLSKDWEAIGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBA6</accession>
    <name>A0A2G8SBA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBA6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBA6"/>
    <dbReference type="OrthoDB" id="2803235at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="384" mass="41025" checksum="38541D00E4A178CC" modified="2018-01-31" version="1">MSASSSSRSDAGHAVFALSPETVLALGSRLSIEVFCRAPTAKKQGKATPLCFAPVPLSGVLKKLDSNSHQRQRRVEHEVALIRVNAPRGKPALAAAQKCEAPKLILRIHAPETPLSPQLLPPATLPESTAVNEDAPVAHSLPCVVDFYEASDQESDTVVPTDCEAGPSTAKAPALTSSGKPRGNLRKRSVDTSPVTSAPAPASLPDDVTVASQHERQPGAGPLERQEDRRSSRTWLQFAESCVNYVGPYDELREAEEQSDDHQMEAVLARLVSEWQAVGQMLIGLAAVNTAVIGFVRGSTAFTIDDFSLGAVTIGAIAAGLGVAMDAWFFLLFSGADAAKFKRLAKDVYGTYFFFCLVCRLPTIHMFVSVLAVGLFLLSTAWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCY4</accession>
    <name>A0A2G8SCY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCY4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCY4"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="220" mass="24086" checksum="E722266CF105A864" modified="2018-01-31" version="1">MDDSIPSIQTAGVGSRFVSQNELEAAKARRDEQWKAAYARLGQEPPPQPTEDAFDGRSLAEKLAANRAAKQEEWEERNKLGNQFRALEEDEVLFLDSVLEKQREEERLRKEMEGEELKHFREAVAARETAANKPPPIGATSAANNSGPPKAKPAPAPVKKDAKKSLKGVLVKKKPVKPANPSGTQVLAAAETKADDKNKSGAERPEGNTREAKRRKVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD53</accession>
    <name>A0A2G8SD53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF866-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD53"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD53"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="18201" checksum="6C271CD21F4C66A3" modified="2018-01-31" version="1">MVRLRLSIKADLENVTDLLPASNDFEFFFKVKCTSCNEEHPKLVTLNPTEEREVTAGKGSTAHFVWRCGLCKRESSAKFEPNEKPKPYTVDANGQFTPFITIDCRGLEFTGFDPKGTWKCVGAESGTPFEVDLEEESEWVDYDEKAALPVGVSKIEAKWARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDI2</accession>
    <name>A0A2G8SDI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDI2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDI2"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="327" mass="36825" checksum="D4816742733597E7" modified="2018-01-31" version="1">MTSTLDASTEQVPISFSDPVPAGGRRGWDWDDDNEYDIWSCKFSADGNEVIAGGCRMIFVYDLIADRRTVKISGHTNDVNSCCWADTASGNVLISASDDTFVKVWDRRSLAETRKPSGVLIGHTEGITYVSAKGDGRYVISNGKDQILRLWDLRMMRSNIDFEGVADKHYGIPRFDYRPAETTGQQYIYSGSSDGKIHIWSLDGRVVQVLDRSYTLSMALDPSAPDPQDITPARVRPCVRDVSWHSQQPILMSTGWLGRHWGMSEGSVVARHEWKGLSKLRNSLEDHVEKQKLERAERAQRRAMRRDAMPGTFVAELSDEDTEMEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDN3</accession>
    <name>A0A2G8SDN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDN3"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF1">
        <property type="entry name" value="CANNONBALL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="9">
        <location>
            <begin position="137"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="514"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="604"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="646"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="688"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="729"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="795" mass="86980" checksum="7DDAB73C7CA59578" modified="2018-01-31" version="1">MSAATPVPSTPDGVSPPSAHPPPETTALDKMVLDYLRARGHKDPEKILEEIERNAAATPPQDKGKQPETAPANSISQEELVKQLAIFAEKPANPDENALKDSSNALQELSSLGNPQNIQNLISSIGPVGAEEILSLDPTDKHQGFRELESWVDGSLDMYRPEFRPILFPIFCHFYLDLVQQGFREAAQDFYTTFSPSLSPVHHSTLHHLSTITLPYHVQTDEVAQRFRSEKYTVRMSRSGFGLLIGWLTEGFGGESTGTGDGFSGDKGKRGRAAIMRVVNNHLRFDVTTSSTTSVTTRAWEESIGFLSAVVPQTNGSTTDSSAYNTSKGELKLGPAPISEELRTETERTLRDQALVDHDPGAQYDLHYARPLPPAGLVSPVISDLPPHPPSFKSVDVKREVEKIRDARKRIRLDPSVLNSANLNTPQGVAVRGRALPSICAYTFYDVGEGVPCCEFSPDTSLLAAGFSESYIRLWSLKGEKLKGMRSDFQTSSIRDVSSLNKIREKGGSTTRKLIGHSGPVYSVTFDPIGGSGSPPKYLLSASADATTRLWSLDTMTNVVAYRGHQNPVWDVKWSPMGIYFATASRDRTARLWSTDRTSALRIYVGHLSDVNAVGFHPNSLYLGTASSDCTARLWDVQRGACVRVFYRHDNVVSTLAFSPDGRYLATSGEDLAIRLWDLGSGKCIKKMLGHTASVYSLAFSAESSLLVSGGADWTVRCWDVKAAGGLPPKTRENGTMVNGTSEDHPPEKEESVENIETTDLLSTFPTKRTPIIDVQFTPRNLCLVAGPHLSSEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEN4</accession>
    <name>A0A2G8SEN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEN4"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="340" mass="36880" checksum="30668D53B7210C67" modified="2018-01-31" version="1">MSMSQSAVLRNARASYAASVIAGVAYGAYAILAAICIHFLLKRRSNGLPHRIILTYTILMFAVTTIYYATGCVWAEVEFVESTANIELYDLQTNSRLSVIKNTAYVFDIYLADSLLIHRLFVVWEGLVPVIVFPSIVWCGTIATGIGLLWSSSRQSASLIESEIIHWQTSFYSCTVSHNIMCTVLIAGRLWYHHGQARKIKALEGTPYSSIIAIIVESAALYSLCGIVYIPLVVKMLPAQFPVTALIGSLTAIAPNLIILRMALGTAASSPAEMSTMAFELSTNRHQNSQGLSRASGIMADNPLSDTPRTAIPLSGGDDVWACEVKSTQLSSAIDQGSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEU7</accession>
    <name>A0A2G8SEU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEU7"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="151" mass="16210" checksum="29FC34636009D6B1" modified="2018-01-31" version="1">MSASRTTGGCAAETEVTAGTVQSSPQGDKGITTEGNDETALEPAVPIRGGGPRGRKRTRRVASPPHWVPESLQMFDLTPVTTTTPVPFLPVRPWEGPEQFEERDSFDESVSTTPYHPQGWSGRLPGPGLLPNNTVGNNAEQITTFQLNIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEW3</accession>
    <name>A0A2G8SEW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEW3"/>
    <dbReference type="OrthoDB" id="3270641at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013567187" description="Transporter" evidence="3">
        <location>
            <begin position="27"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="32360" checksum="487D309966563AD7" modified="2018-01-31" version="1">MLAAPPLLRPLLVLCLLLPIVLVSTALVNITIDDTDGDASQDSTLTFSPVGFWAQGQDCPTCNVHSGNTTDTIDVSQVFDGTWHDSTFHPGDPDHTITASFIGTAVYVYNIIGNQIPSTITFTNLTFWINSDLVGSYVHPPENTAGFEYGVLVYANTSLPNGQHFLTIRAGGGPNASLILFDRLVYTQDSNSSLSPSGPSVSISFPSSTPLPATSAPASGSSKSSPPIGAIVGGVVGGVVGLAILGLVAFLVFRAQRQTAAPPPRRRSTRSSSAAGHSIPKADRCPALPSSGCPTCASGVRASGSCPGVLVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF04</accession>
    <name>A0A2G8SF04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF04"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF04"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF18">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="579" mass="67039" checksum="C344DF5686DE8E74" modified="2018-01-31" version="1">MLGDAVVQMPSDLRPTSTFDLDSPLESSYRPKGITRLTVHIPTAYNEQVKAEPHPPPRWRTPEFMAYYVVFVCALPIMFWIPYRLSSPSHPNYPYYEGSLSPGWLFGRRVDNSDSQYRSFRNGLLPLTFLAAVFLCLKQLCGVFVRKRLLLSPTDHVTRSLFLCIVSILLLFVLHGTSAIKVLGILFANFLIAKNCKGSKASPILTWAFNAFILYWNDMHQGHRFGDLHPLLAFMDAWQGVYPRWHISFNITTLRLISFNMDYYWACRGVGLPESSLSDKHRPRVNHSLETYSLLNYIIYAIYPPLYIGGPIMTFNDFMWQLLRPKKISWRTVLGYLGRFIVCVMTLEMILHFMYVVAIKDRKAWVGYSAAELCMVGFWNLIVVWLKLLVPWRFFRLWALMDGVDPPENMVRCMANNYSPLGFWRSWHRSYNLWIVRYIYIPLGGTRNLVFTSVLVFTFVALWHDLSFKLLAWGWLVSLFILPEVAARHFLPSSKYGDRPWFRHVGAVGGVLNVLMMMTANLVGFVIGVDGMKYMIEQIFGSWEGIQFLLVASACLFVGVQVMFEYREEEARQGIVRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFB9</accession>
    <name>A0A2G8SFB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFB9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFB9"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF5">
        <property type="entry name" value="ENOYL-(ACYL CARRIER) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="195" mass="21903" checksum="47294C1C7BACC50F" modified="2018-01-31" version="1">MDEIMRSFDTNVFATIRTAKAVIPHMAARKRGTVVNVGSIAGIVRPSPQADLLILIVRPIPWSGVYSATKAALHSLTDALYMECKPLHIHVVRSNFVANQGPCVSLPPDSLYGDYIDAVLLHLTMRQTNKPLPADVFARRTVDAVLSAGGPPRYMSIGWMAGWYRVYEWLPRRWVLDLFWKWMGEGPRKAAQKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGG9</accession>
    <name>A0A2G8SGG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGG9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGG9"/>
    <dbReference type="OrthoDB" id="2730708at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="167"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="38996" checksum="D95A22AFDA532030" modified="2018-01-31" version="1">MPGATARNRDLAGSLYILAAMTPAISVDLKQRIVNLYNNDDWSMQEIADTLKVSKGLVSKVIGIYRDYGTVIDPTKQRTGRPPYFNHDDHAFLQQTLAANHTLYLDEIQDRLAKVRNLHVSIATISRALRNEGMSWKGVSKAALERDEELRMLWRLEMVDYDDPELFVFLDESAVDNHTVQRNHGWSHTGIPCVSRGAFLRGTCFSILPALTVDGIIALDIFEGSVNKEKFIEFLRNNVAPKLNPFPAKRSIVIIDNCAIHHDEDIRHLIEDECGAKLIYLPPYSPDFNPIEEAFSSIKAWLRRNEGMFTHSRELPWLIHQAAASVTAEKARMWFEDCGYIND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGI3</accession>
    <name>A0A2G8SGI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGI3"/>
    <dbReference type="OrthoDB" id="2757425at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="99" mass="11213" checksum="10EA9D554FE39929" modified="2018-01-31" version="1">MYANEVASPDAQTIGDIVTKLQGKGAWHGLHQAGQFMSAVPKNEEVVAAFCHVYTFIEERLTQEERDLIQFDPVMLEHALCKYQQLMRELKDGPGSEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH92</accession>
    <name>A0A2G8SH92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_04594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH92"/>
    <dbReference type="STRING" id="1077348.A0A2G8SH92"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="339" mass="36286" checksum="7CFF3870833CD36F" modified="2018-01-31" version="1">MFWRVVQAFGASSAMSVGAGVIGDIYRLEERGYAMGLFFGASLLGPAIAPLCGGLAAHYGSWRYMQWALFVMGITAIISMALWLPETLDPEKLNKVKVEGKTVLKVLNPLASLTLLRSPAILVVTLAGTTALLADWVLMVPLSYTVGEAYGISNAAIIGALFIPLGVGNMVGAPLAGYLSDRAIIVWRERRGGVWVPEDRLRAAIWGTAFCVPVSTLAAGLTMKYVPGLPGIAILLVCLFLNGVGVDIVLTPSASYYVDILHDRSAEAMAASFACRALILAFATAWTFPLINTIGVLATNTLLALIAWLGYGMILFTIKYGDHMRAWVDIGYTTSRDTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJF6</accession>
    <name>A0A2G8SJF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03608</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJF6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJF6"/>
    <dbReference type="OrthoDB" id="2750010at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28515" checksum="4CA7DF9D33FF890B" modified="2018-01-31" version="1">MSSCNRVPHSPELTLSTRRTPCQGHSDVQTLLFPLGFHPDPATDSSEVDSSDNEGFAVTDDNCKCYTGKSSNFELVRTVIDLKSKHKCHDSIDTPSDNPINELQKRFRPGIQHLSTVQGMRLSPPVRTAELVDGYFGHLNAYFALLHRPTFERDVRSGLHLRDRGFGAVVLLVCAAGSAWAYGSLHAQPRQTPGWQWFDKVSSASFSLIARPRLYDVQACALMAAYVNATNSPQGSLPILSLGIVVGVLVGWGEGYRDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKL8</accession>
    <name>A0A2G8SKL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03086</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKL8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKL8"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17806" checksum="1FC00CD2362D5682" modified="2018-01-31" version="1">MSAPTNGHTAKALELFLAMIVEEASNVTVERGSKRVEAYHLKHAIETVDMLDFLKEIVEAVPDPSAGGTIDVEAENAEARARKRGKGKDKDKPEKEKKEKAGENGEGKPKRRSRKKKAVQEEEEEEETRDEMDVEEDEEEGGGRGRRRRDEDDDDWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL93</accession>
    <name>A0A2G8SL93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL93"/>
    <dbReference type="STRING" id="1077348.A0A2G8SL93"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="270" mass="30312" checksum="96F3966B4EA3CF6D" modified="2018-01-31" version="1">MLNRKTWKFLARTTETYGPIYLLKGHFEVRFKLFPRDSLQILPSVRSTAQGDGGLTQRPVIRNSNLHVFLGPSVLTTVGAAHRRQRKLLNPVFSAAHLRDMAHIFYSVARKMRSVLAARVPADGTEKVLDRNGWMARTTLEMLGQAGLGYSFDNFVEDSTDPYGESLKMFLLMPNENGLRLVRISDTMKESDGFKVCQLEMSTSPVLHAARQRGCQCVHSISEVVPVAMLSSFAFELTNQEITWNSSGVMHPTMGEESTKFGMLLKERAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM45</accession>
    <name>A0A2G8SM45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM45"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="13631" checksum="4CCA6CDA8B95CE1F" modified="2018-01-31" version="1">MSAVAQHHARSQIRAPVPEVSRRPEDKFFSIRGRPETRRWDFEGVTLEVTKRSYSQAEPAHISYQINLGPVLPEKDRLIVYVKHPKDDDVVDGLVANCAAYKRCLDDLIANAASFSSQKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMH4</accession>
    <name>A0A2G8SMH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMH4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMH4"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="51343" checksum="87D09B02E64DAF5C" modified="2018-01-31" version="1">MRAKSTYRGHGKGAGRVYPVPELNTVTQSTANTEPDLLPDADVTEGLLSEPLQCFALRSIPGGTEHSSVQVKNFRYLGSYNWLDAPHPTILVPGSPDIWRDRPVPFRVPFDEGLQIFDPNGYHMGSSSSSPLLPLFRAVDVVAEDNADTSMDWPSIDIVADRGSLRKLLRWIKHEDSQRLQVSEPSSTTQAGSYPSAKLQDFRIDLQLGGAKTVLMQRWDTRTCQYVTPPNFGCRVNFEKATLTPAPGCELSSDHYRIIQYELEGLQMVVRFEVDACIAPPSTASDSESANDLSDALAGLSLACQTLPPPGPGATVSTSPDNLDSIVKVIHGGTQVPQSSIIEISTRSVKGAHRHNWEETYTQLFLSQTPLHYLAVHERGQFRTITTRPLNMPEFQRIAARDSVQRNFKQLICLLREIQALVTKHGRRGHLSLVCRDGRLEVFERGDGNDIGCLPDSELARFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMK5</accession>
    <name>A0A2G8SMK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMK5"/>
    <dbReference type="OrthoDB" id="2731950at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="237"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="480" mass="53543" checksum="5071E48561D9B7D3" modified="2018-01-31" version="1">MATTAASGAEPVPASVVTPKPVASMAKIPDWLLTHPELHKRGIVVHRPVQPFTVYETEWQPEGPIYVVKGINPSRPEADIYDLLDRYSDSPADHTIPHEVIRCERPLLVMPFVGFIEYAITYKTSSMLAVFGQILEGVEHMHWLRIAHGDIYAPNVVAASEDDAKRDARLTAGRVYLIDFETSRQFEHGPGVQTAVPLPNTHVIPPLDMKVFDPFSWDVYCLGKTLDIMVQRVFGSESTAKPWIVGCFARWLKGNEVGSSMPSLLDVPDWLKDHPDLLARDIKLFMALKPYGGPYYTARPRGSTIPQYVVKVLDPATEEGAISERLQDHPSSPNHGIPSEIIPSEPRLLVMPFVGSLSLLDYIGRPNSFFLDLFHQIIEGVEYLHRLQIAHLDICIGNVLYAFPYEAATDPRIVAGKVYFIDFHTSRQLALEPGRQPPILLPPSQLEKPAGVTSLDPYSFDVYCAGTLMLRLVEVGGMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMP3</accession>
    <name>A0A2G8SMP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMP3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMP3"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="6">
        <location>
            <begin position="195"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="393" mass="44345" checksum="DD24BB6C97B73568" modified="2018-01-31" version="1">MTSARDDPFHSSWFVFEEPPAAGHWGRVRFRTNNSPAKAIAPLNRNPAAVPHGSVANVKGKRRFTIDRLLRFTAAILVVCAVLTTATRSQYGEPAFLWLQDQITSLPFRRPPTDPSNVPPVVQDHVQKYVQHLVEPYLEKHLPELVQLYLDEHLPHLVRFCVEEHAQQRVQPSLEQYVQRYVSKHISQHTLTLLRQLIPGQHDYAYHADGGRIVPKLTTGEAIKSRNHNPPEVVLRPNLEGGRCWNIPGSRGQVGISVSCLIYPSHITVDHIPADLADDAQQAPRRMRFWGSVDGSQNGGRFKEYLSLYPGTYQPPSAGPSMTNGYQFVHLADFEYDVNATSHVQTFPVHAFVPPLEMDFGVFVIEVLDNWGGSSTCLYRLRIHGQTSFRDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNB2</accession>
    <name>A0A2G8SNB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNB2"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="424" mass="45984" checksum="1C19332D24F242B3" modified="2018-01-31" version="1">MFSHELFDFASTGHLSDAHVDAPDPYHDALFDSYIDSSCVDQSFVSTTRDPHDPLHPTRALHLITSASQCSDFACCGQALPDLHRLLEHFEEEHVLPLPSDARPLFSSPVYAQPRSGPCTSYILSYPQPDPPLHTPAVPHSIPASPTPRGVLPSLQFSEIPPVAVPDLTHTPLSPSPSASSATSAHSSPEPGEPLCLPPALFSFQPTPSSSPSRGHRDRPRGHATSDTDVDMDESDEEASADGGFEDTPPRTRSAPTSSSHSSLPAPVLGNTAGPHRRVKNKTSAARMEPFGTARRSPSERERAPSSPKRRDGREKAFKCPVSARAGSVLFSRRWVRSYGGEERTRVRCTPEIRDSVIESQMAELSWCCPHTSPPGRGVCRVRFPGSPRSPLLALALRIFPIQICGMWVSESTGVTRHRGQGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNH5</accession>
    <name>A0A2G8SNH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNH5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNH5"/>
    <dbReference type="OrthoDB" id="5303367at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="78"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="583" mass="63337" checksum="94EC61544BF5CC0D" modified="2018-01-31" version="1">MSSVSPLTPFSLPDTLKACEGAPGQGDLGDKPLRVLVLQAGDTAYDLIKYTGQPFAAISYTWPSDPPWPRLGASNDKSDSCAAYNAGTRRAVWLDYHCINQSDEVEKTAQVAIFQKIYARSEITLIMLEDVGFTSEEFAALLRSNLKANQETAALVRRILAARWFSRAWCSQELVLSRKAVFFLHNTSTSGDAHRLDSDRLWHCIEVARRHDGSIPSFSSPRGSVRDELVTKTTSWALRIVQPLECSDGYDKLSLVCNLIRFVYRFTARPGAFRAPSESAPTVELNVLKMVNVMAIVRREFSLLTANHGPGNPLQGELGFGWAGVPVHGDGVSDMWVPKDYEVARDPDVSVDGDGLLLRGVVASVVREVMWEVARDGTGLHVAIDGETPSAVAEFPSNEGWTWSAESLGLRDLLTVLARIGTGPNGAHSGDVPLHARIALAYVLADPDYKDQPEPVVGDAVSLVQGILGEVIGPLKYIASALKFIHRAGGRMLFSTVLLSEGSVLLVSGNAPHGQLRGRLLFQPFVVRPKVFSPPMAMTANSMILDPAPLDGPKAIYRCVGCVRGLGMALETPENAARRLRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNL2</accession>
    <name>A0A2G8SNL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNL2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNL2"/>
    <dbReference type="OrthoDB" id="5591297at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31285:SF0">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="33959" checksum="FBDD385176271547" modified="2018-01-31" version="1">MSFASLLQRVQRGLSAVELVHTSHPRWPLPPGPFTSPTLQISVLDSSFNPPTLAHLALANALPPPPQSAPSTPAPHDFDARLLLLSVRNADKQLKPGDATYEQRMEMMVLLAQELAPRQATSSQPLAREPNVAVAIIDEPTFVGKSASLLDFLRKRILDLHRSPGVIFASPSDAFPSPKLTFLMGTDTIVRFFAHRYYPDERAMATSLRRFFSPNENDSRIICVRRTSEGLSGAAEESVEIQIPDFIREITPGDRISFVDIGDEERTLSSSQVRGMLANREESWKSMVSPMIARCIIEHCLYSTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNM5</accession>
    <name>A0A2G8SNM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_02048</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNM5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNM5"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 9 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="12">
        <location>
            <begin position="6"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL35323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="108" mass="11694" checksum="40A39503BD305363" modified="2018-01-31" version="1">MPFAPGDSGKGAGLFKTRCAQCHTLGAGEPHKVGPNLHGIFGRKTGQGEGFSYTAANVNKGITWDETTLFEYLENPKKYIPGTKMAFAGLKKDKDRNDLITYLKEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNS3</accession>
    <name>A0A2G8SNS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">GSI_02099</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNS3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNS3"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="245" mass="26245" checksum="2D8B1053BD5C8CA9" modified="2018-01-31" version="1">MATRIQFENSSDIGVFSKLTNSYCLCAIQGSTNFYSAFESELGDVVPIVHTSIGGTRIIGRLTAGNRHGLLVPSTTTDQELQHLRNSLPDAVAIQRVEERLSALGNVIACNDYVALVHPDIDRETEEIIADVLKVEVFRQTIADNVLVGSYAVISNQGGIVHPKTSIQDQDELSSLLQVPLVAGTVNRGSDVLGAGLVVNDWCAFTGLDTTATEISVIEAAFKLQGQSSAAVIGEMRDSLIDSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPS8</accession>
    <name>A0A2G8SPS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPS8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="160" mass="17711" checksum="3C3EB46CE2462407" modified="2018-01-31" version="1">MSSPAYLQAAGAPTMRLLIVSAKPPKAILNILAERSIDLSQFRARFKPLWEEKNRTARSLCVRKRSLRISVKVRVWGYACTGPGDLPASESAELELMAETRYGLLLLRWTCRTLNLYANSSNVLNVATRDTASNALSPILSLSTEELVIHSKLHGEALQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQS7</accession>
    <name>A0A2G8SQS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_01588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQS7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQS7"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="131" mass="15243" checksum="3B070F628D7D467B" modified="2018-01-31" version="1">MRMLSQEDEHDDNTEVTWEDQQRINTFSKLNTRLRSIEEKIEVLKAEKEALDDISMELELADEDQPVMYRVGEAFIHLPHPRAVKRLEKDLSALNDELGKYTSGAEECEKSMKELKVTLYAKFGRAINLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRC5</accession>
    <name>A0A2G8SRC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldose 1-epimerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00005</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRC5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRC5"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654734" description="Aldose 1-epimerase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="45521" checksum="45B69EE5C536D83F" modified="2018-01-31" version="1">MVFLHHLSLGLLQAAVAMHMLAAAATAAQASESQAPDWPFDVTTLRAPDGSITAKFVSFGATMTELWVRDREGAARDVVLGYDDNVSLELESACELDAERSRGGGGVLQTKLLTDPAHPVFNPIVGRYANRIKNGTFSIPITKHPQPDGPNVYHIPTNDHDGQDTLHGGIYGWDRRNWTVVARTDTSVTYHHLDAADEGFPGDVEATVTHSVESGGTLRTSVHASATEKTPIMLTQHIYWNLDAFQGGPGSESDTVLAHKLRVDASRVVAVDGDAIPTGELVDVGGTPFDFRETQAIGARWGDTVGLCGGGCQGYDNCWIYDASEEVKPGVSLWSDLSGIRLDVTTDNPAVQVYTGFWLDTPRKVVHGGPGVNYTKWSAVAIEQEGYIDAINTPEWGVDQIYYPGKDYSWESVYKFSTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRH8</accession>
    <name>A0A2G8SRH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00011</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRH8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRH8"/>
    <dbReference type="OrthoDB" id="3214739at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="313"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="569" mass="61411" checksum="DA35904EAB9B945E" modified="2018-01-31" version="1">MPDITYRTSYLEQGTYACSVTPTVINDDYGQDMSSGEEEGSDADAPRDDDDQSESGDDPVLDDGGDDLEAHLAAERPIWQERDSSVPGKGKARAATTPAIKSTLLPADFDNSSGSEFEPFEDEDEDEDDTEEDELDEELGAGKVEVGRERRTVGSVASSTHPKKVKVLSKAQLARQQLETPTWKPSTSIVSMIPANTNCPSQCASQAGNPDPASRSAVSIMPSLTPTSVDSDVRPADGGEVLHVEASDHDGEHHDDDNDDDNTAPSPPVIDLVSNPPADYFVLVFPPGGGPLNISPQQSPVQAVLHGANATVIKNVVFENAFPDSFGRCKFVADALFEGAIVHDYTGLLERLKTDPPFLHSMSGVAKQHISNFRGTIKKAAEGFVHGFYGVGGLPPAECADKVSFMLENLTYVYPFIYEPGKRSVPWHKPYSHPCVLALLTSSFFQGPKSIAAKYPDLFPSSDPDRLREHEIPPSMLALVGVAIHAALAEWKSGVHRAIPFAADSFVDVYNEHMTTINGIKPKNLGGYHTMLHRLYKSASNITPIAEPVPASVSTALDRVDVDAMEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRU7</accession>
    <name>A0A2G8SRU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRU7"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013701460" evidence="2">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="29077" checksum="F94C558056D60AD7" modified="2018-01-31" version="1">MFAATLLCQILLATAALAIPTSRDRLSARVARRDAASFTHQSQPNQPVEAASVAEPVAEVNAVTNATDAKVVHSTNWAGAVLSEKTATYKTVTGTFVVPHPKEPSGGSGRHSSAAWVGIDGASCGHAILQTGVDFNVNGSSVSYNAWYEWFPAPAHDFTGISFKAGDHVTVAVTATSKTSGKATITNKSTGKTVSHTFTGQKALCEENAEWIVEDFSVNGSLVPFANFGKVEFTDATATTLKGKAVGPAGATLWDLVKSGKVVTKSSTGNREVTISYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSA0</accession>
    <name>A0A2G8SSA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSA0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSA0"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013909948" description="Glucosidase 2 subunit beta" evidence="6">
        <location>
            <begin position="16"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="7">
        <location>
            <begin position="430"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="150"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="548" mass="61208" checksum="666806D9C640C97A" modified="2018-01-31" version="1">MHPWLLLLLPLHVLASKDRLLGVSPELATRYVSTKKGTVETWQCLDGSKTIDWSAVNDDFCDCADGSDEPGTGACPNSRFYCVNAGHVGSYIPSTRVRDGLCEPECCDGSDEPEGVCPNVCKEIGAEYRERLKADNKLRKTGSKIRSTYIAFAQKEKKRLEEEIAASAQEISTREKEVDRLKDLVERTESLSAAALEEMKSSPLYQSLKTHYTALKSLQREHKKHLEREKALGDILDQLRTGYNPNYQDMAVLEAVRGWEQLAGLPHINDVGKEEENADELGSDDVEDAATEDEEVLEEGMWTAMQLEYQLDDLLKTDYDGLLLEHDKHAGTPTSPTAILFNLSAYLPDTLVPQYESLRDQVVGWLALFGFTQSKSDSAADTSKAQKALNDAEHSLNLARKEKADKDQELARLFDSEWYGQEGEWKKLSGSCIEKEVGDYIYEVCLFDEARQKPLRGGQTFSLGKFAGWNTAESIEKGTPAYYSKQLYTLGAKCWNGPQRSVMLVMSCGLENALLSVAEPEKCEYEFKVTSPALCLAPSAEDIKREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSE8</accession>
    <name>A0A2G8SSE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prolyl endopeptidase</fullName>
            <ecNumber evidence="7">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_00322</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Pro-|-Xaa &gt;&gt; Ala-|-Xaa in oligopeptides.</text>
            <dbReference type="EC" id="3.4.21.26"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase S9A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSE8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSE8"/>
    <dbReference type="OrthoDB" id="248387at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070012">
        <property type="term" value="F:oligopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.120:FF:000001">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000005">
        <property type="entry name" value="Prolyl endopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.120">
        <property type="entry name" value="Prolyl oligopeptidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051167">
        <property type="entry name" value="Prolyl_oligopep/macrocyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42881:SF2">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9A N-terminal" evidence="9">
        <location>
            <begin position="56"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="8">
        <location>
            <begin position="567"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL36633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="787" mass="88434" checksum="6372681C12C7284D" modified="2018-01-31" version="1">MPCLFSSVAASLRTPSVATHISRTIRYTLSTRSISTSCPRAMPPTPTAWVPNRYPAARRLDHVDVYKSEKHGEVRVPDPYRWLEQNTSETEQWTTAQEKYTREYLDQNPERNDLEEQIRKNMDYAKFSAPSLKDDGRWYWHYNTGLQAQSVIYRSKDGTLPDFSKEDGAGGEVFFDPNLLSSDGTASINVSSFSRSGDHFAYGISRSGSDFCTIYVRPTSVPLAPVEGKEVSHDEGRLSEELRFVKFSGISWTHDSKGFFYQRFADRQSHGSASEDKAGTEIDSDKNAMLYYHKLGTPQSEDILVYKDPSNPEWMWGTQITEVDGRYLLLSVRRDTSRKTLLWVADLQKDTIGPNLVWDKVVDEFEANYEYVANDGTKLYLLTNKDAPQYKLVTVDLADAPEKRVFQDLIPHDEHAHLQDVLAVNGDYAAVVYKRNVKDEIYVYQLSTGKQLQRLAPDFVGAATINGRRKQSWFFSTLTGFTTPGLVAKYDFSVKEEDKRWSIYRTTLVSGLNPDDFTAEQVWYTSKDGTRVPMFIVRHKDTQFDGTAPALQYGYGGFTISINPFFSPAILTWMQKYGAILAVANIRGGGEFGEEWHLAGTRERKVNCFDDFIAATQYLIDNKYAAPGKVAINGGSNGGLLVAACVNRAPEGLLGAAVADVGVLDFLKFADFTIGRAWTSDYGDPHDPHDFDFIYPVSPLHNIPEDKVLPPFMLVTADHDDRVVPLHSFKHAATLQHLKAGNPNPLLIRIDKKAGHGAGKSTQQRIQEWADKYGFIAQALGLKPRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSQ6</accession>
    <name>A0A2G8SSQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSQ6"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN / WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232:SF1">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN _ WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="456" mass="49863" checksum="166BDD5FD9581993" modified="2018-01-31" version="1">MVSQAPQRSQTLDTAAPVLAHGGNMGAVYDATVRAPTFRSGTLSIELPPHVRPFDWKDFSSIRPQAQQDVDHSELRVAPVLSTLPSDTSTLLPNSLAQPGSSVVTDRSDPADADEQEDTGAASQPIDFTPKLFRCAQRIQMRKDSHDKPRRLLTLRPSGFLSVTMRGSLDLVEQASLRYTPLRTSAGDGARQLVEDACVLHGTHKRTVVIGRAGNNRQLSLVRIEDGRVRDIGSFERRSQADKKCGISAVCALMQPGAFATGGYDHLVNLWTLPNEGDSPPVPSAVLAIKHSSAVHSILPVRDTSHKLLTGGADCTLAIYDLSSERTVNTLKLSNPIYHVHAVESPFCALLELGHREFQFEVRDCRLVPETPALRFGYSNAKVHGRYTRGSVYTQVFACGGNEDGCIRLWDLRKSSEILETVTCFSGKKVIQVEFDGTRMAVCSEDHQIAFLTPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSS9</accession>
    <name>A0A2G8SSS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSS9"/>
    <dbReference type="OrthoDB" id="2996389at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="50046" checksum="9F9DA0964191C5F6" modified="2018-01-31" version="1">MPPRLKRAPPYEDDPECKYIVIDDPWPGNKVGKERDALYWNYLCAWVRFMFDKKHEPECVFSVNTRNEVIVQLPAEADIVPILGAHPWVKVLTRGDPRDRDRVSHVFEYDYRMKGEPGNHNWLANHATTTGDPPPHLRFPVKFPYPHVSWASPRGKSCANISLPLPPTRQPTPIPDTSGFTPYQRASQLTSSTISSAEARKEERRDRNPQSGGPSQSGKIDPYAKESNALRTVKQEETDVKPRIKRENGAHVKTEAVKSEPALYAPSKSFRSAVEQLQQSRASHDGRFATLPGEPSELGGVKPEEEPPRGPSDAFIAAFHNVRGDEEHEQRAPAPEPKMKDETQESSYQPSNAFIAAIQELRRPSSATDDDQTTSTPSAGVQVKQDPEARRSSTYSALLADSKVKREPEDERRQATGANPEAQAIFSLKRVKEEPHEGRCGKRIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STS7</accession>
    <name>A0A2G8STS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSI_00805</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STS7"/>
    <dbReference type="STRING" id="1077348.A0A2G8STS7"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000002">
        <property type="entry name" value="Histidinol dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="215"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="380"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PIL37113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="875" mass="92094" checksum="E478C10195D4D245" modified="2018-01-31" version="1">MSVFLPLLDAHVGDGALLAPLARIGPLILPPDFALTTSIPKNATRYILVDTDSSLSMDHVISLLDQGADKVIVPLALAKGLAGVVPAHRLLLLLDVANVSAVSDTIRSGVSGVLIKTPSVDVDFISSFTRFFAGSSVHVFPAASVEPPSRSTIRALHAANTTLVIPASLLTLSATDAKQINIADAFLANIVSDRKDGLFPTVVSSHLDGGRTLGLVYSSLESIQESIVSGKGVYQSRKHGLWRKGETSGATQDVVRIRLDCDADALEFSVVQHGAGFCHLERQSCFGTGEVSGLSALEHTLKSRLESAPEGSYTRRLFGDPELLRSKIMEEADELCRADTSEEIAFEAADLLYFALTRCIAGGVYLADIARSLDEKAKKVTRRPGNAKPQWTSKLTTTEGPAAHCAASTSAETPKPPTRPAATVPASATVDGAGDSGAPIRMRTHDLSATTVAERAQLLRRPVLKSDEMIAKVRPIVDDVRARGDAALLELTAKFDKAQLATPVIRPPFAPETMVLPDDVRAAIDVAYANIHKFHKAQAADTTLRVETMPGVVCSRFARPIARVGLYIPGGTAILPSTALMLGIPAQVAGCKEIVLATPPRPDGSVSPEVMYVAQLVGASAILKAGGAQAVAALAYGTASVPKVDKIFGPGNQWVTAAKMLVQNDTDALVAIDMPAGPSEVLVIADHTADAAFVAADLLSQAEHGVDSQVVLVTVGLPSERIAEIEAEVDRQARALTRVDIVRQSIPKSIIVRTGSVEEAIAFSNDYAPEHLILHLENAPAAVAAVENAGSVFVGPYSPESCGDYASGTNHTLPTNGYARQFSGVNTLSFQKHITSQEVTADGLKGLGPVVATLADCEGLDAHANAVRVRLRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STV1</accession>
    <name>A0A2G8STV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STV1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="15515" checksum="EC3413A5D85D282B" modified="2018-01-31" version="1">MAGTTTEEEQSVVNAWLNARSQLRDAAMAIIAGRDNQVPATTLNSLRQAHVVAAQEYLYQAARLLDELGGDARFWLVPLGGAPLRPEDVHALERAIAVGQEEMCRLFRALSAASQLLQRERDQLIELWPRSMISGGSCKSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUG3</accession>
    <name>A0A2G8SUG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUG3"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="215"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="414" mass="47493" checksum="06985D277E8387AA" modified="2018-01-31" version="1">MASQKFSVFLTQLAASLREEKGPELAYLLKPTSEHGKALVKDFRGNITRQSLSHYEGSLESPWDEIAIQYVLVVNHCGKKRATEAFKEQCTLLSLFLRFFATNSGWTLPALFSILRDLRDLAFDADLEGVSNGQEGTASMEEAARIIMKAFSNCVTDRQSPIQESRKWGVYYVVGLILKCYFRVKRISLSKNILRAIEANPDIPPLSQYPRAHQVTYRYYIGMLSFLSEDFAKAEQELTQAFYNCYTGAHSNHERVLTYLIPLRMFRGHLPSKELLQRFPVLEDLYSPFIHAIRTGDIRTYDASLDRFERRLVDLNLWLTLERARELCIRGLFRRVWIAAEKSTRIPISMFHAALLIAGQEEMTAEEAECLVANMVYKGFMRGYISHEKQMVVIAKTDAFPRLADRPAPFAMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUJ1</accession>
    <name>A0A2G8SUJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SWC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUJ1"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL37430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="501" mass="55193" checksum="1F0E6EB72A5CC8F0" modified="2018-01-31" version="1">MAASAADVRSILSIPNPPPAGPSTQAKKPQAAERAKKPEGIPRELYALIGPTAPTLVTQFAKPRLKQKPNLGGTSTPEDADYPFAKYNVPATPYVYSQDEYTRLLEDSKWTKEETDYLFNLVRDYDGRFFVVHDRYEFPGRPERSLEELKDRYFSVCRKLVRNRPWAGDEASKLALISSLTYDKGKRASSLSYEVSPVNVPVAIDKEILRKQYVASLENRTPEQIAEEDALYFELEKLKENERRFKKDRDELLRTLCGIESGLPDISIEDDGLASAALDTKKKKKTVAGSVEPQTPITPSASNVIALPQPPPKKSAAKSAAYDALHCIVRTEVEQTAGSSTKAAHIPVHLRSYKLAQPKTAIAPRVFQLLGELSISHSRLVMPTRDNLAKFASLVDAAQQLVEIKKAVDKHEQDIKTSKARLATLRGENPEGVEGGDGDALGTPVPMDVDDGAEAEGEVDGRAQSVMSTRSTRSRKQGRRSMSISSVDTAGGPNPKRQKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUJ8</accession>
    <name>A0A2G8SUJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUJ8"/>
    <dbReference type="OrthoDB" id="2793297at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="259" mass="27588" checksum="2DEB9F07DC5F3059" modified="2018-01-31" version="1">MNQNQIAVITSLASPPVTPVQRQTRSGALYAPAEPSQAKQPRKGHPRSGCPNVDPPIPPGSPVDEASGRTKSRTPVSNPGYNVINQQHVNVNFHYHASPNALLALVLPSAPLPEEPDSSDPEPPSPSAVGDLSESGDSTPSEPPNDDHWDLIHALLPEELVAKEHGYAVKVVYPEDSWEDPNQGLFILARDAATLRGTYNRARKAAKSGTSLATIVREESHKSLGDAVETVVDAMAGLDVGGPKPQGSRKPHKSRKNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVF6</accession>
    <name>A0A2G8SVF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVF6"/>
    <dbReference type="OrthoDB" id="2750707at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40878" checksum="4C8F0BF3F5518999" modified="2018-01-31" version="1">MADFRSPHPLRSDFAHPSPAVVSAYTICHAAERVVDPIQDHWPPDDPTMKTRLINIRILGHLLSQTGFLSDAAISRVATSVFTCRKDPAGTDEADVEALNELGEFYRDHLLRPFRKFKSLTPNISSPPSPPSFKLSKEEVDQMLAEPHRSHSQSRHLAMQREDFRCIVTRTLDKPYAKALRPPGYPKAQTLEFCHIFPESTNCDVDDNAKKRGVWNALESLGYTNVVNDFATAEKIHSLENTMMMVFNVCDNFDTLDLWFEPIEGVPNRYRIRSLLVISPEIADGQEVTFQSADSRLALPNPEYLRIHAACCRVANLSGASGLFYEIEGDLMSDPDPTTEGPEFARALHTHLDHLSLTAVQEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RL53</accession>
    <name>A0A2G8RL53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_14985</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RL53"/>
    <dbReference type="STRING" id="1077348.A0A2G8RL53"/>
    <dbReference type="OrthoDB" id="3243429at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="196"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL22297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="656" mass="72234" checksum="586191A3B44428E5" modified="2018-01-31" version="1">MAYLKRKSDEFVAFKAYKAYAENCLGLRIKATWDDKGSEYMGQEYIDFCAEHGIHQQHTEPDEPHQNGVAEQANRTTSEGATALLAQAKLPPSFWGHAVSTFKGDGCKPDVSYFRVFGCLAYVLIHKKDRKVLSLQPHMHKCIFIGYPDGTKAWKFWNPAAKKIIISSHAVFNEQYFPGNSPFINVFGLPLDNVDIPGGPDDAAPPEDGVPDVPELYNQGGDDDYDDPAPPAPPAPQPAPPPSHQLSLLQSPLPPASPPPALPPAPSPSPPPTWPPPAPVAHPPAPSVHQGAQNCTGFRPYPALARKELPVCSSHPPGSLNKRVLECQNLIPQRLRICSASSVPPPPEPECSSSPDPIIEAPVDAPAAPGLRQDSDEEALHVMLAGIEDVYSDPSFDYLSYDEALEVSFKSVVEQASKVNQEHFGEPRSMSEVMALEPEECNKWLKAVQDELQSLVKNGTFKLVLLPPGRKAIGSQWVFWVKHNADSLIECYKGRLVAKGFFQTLASISHPGMAYWKAIKHLFHYIRGTLDYKLTYAPLPKPELFSSFTNADHMGCPDTGRSISGPLWLTEFGYDISSASKLRIDNLSALSVAKNPEHHGCMKHLNLHFYWLQNKVAKGHIEVVHLRTSHMPADILTKSLPKPKVLEMVKMVGLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLP0</accession>
    <name>A0A2G8RLP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15124</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLP0"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="533" mass="59205" checksum="A590937B4244AE30" modified="2018-01-31" version="1">MADLFPPDLPRFNGLNAAGSPRKDAPIFARRHASDTLLRDGLPYSKKLVAHTSCVNALAVSKDGRWLASAGDDPYLQVWDFHQEALSEPASKFVGPRGNVFTLAFSASGQFVYSGDTRNIIHQYDISDLKDPVTRIERGSQAGSPSWSNHQHGDSLRAISCHPEQDALFLSAAEDGCMILHDMRADPRYTRAQRILQHRAELTGLQYHPTMPNIFATSDNRGCVCLRDIRMAFGPLSQRRDEGVVHKYVTTVARQGVSNMARPEASSLVFDREGRRLAVTMLHHLPTLYALNDPYPIAVFSGRHYPNGAAVSPGEKTYSNSCTMKHGSFGSLGSDRDLYYAQGSDDFRTYVWKIPEESALLESRMVVENSDWMKARRPGELGYSATLLGPRYVPQEISTPHARLTGHDSIINTALCHPYEPYILTAGIERYIRLHSPTAASPSTEPLVPTPKAVRTIASSSPGAHDVFLRAMGMLDETDLDDSDDSQSIALFDQILRMEGDGDVFAIRAWREDEEDTSDEDEDKDWAEGTLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN65</accession>
    <name>A0A2G8RN65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN65"/>
    <dbReference type="OrthoDB" id="2755641at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="292" mass="31395" checksum="E3D360B1DC375D55" modified="2018-01-31" version="1">MITGMGDTKLPPFPRDSKAPLDTPPAYSERLTPAPREVYTTAAPAPHAPPPLAPNPFSLPSTSQGPPPQTQFAHGSGRPVPAPPSLPSFPSPPSPPSPPPSHPARAADASSYQSSSTSTSKDKGKGKCKSGSGKVARAMGQGMFALVAMPVVATAAAVYGSGKLIEGIGRGLSAGPEAVLKAYRKVDGKIKGAGAGAQEEAEKEKEKEKEKEKEAREREREREWHQYQYQQQQKYEQQRKYEYEQRGEWGEVPVKMDKSPMGSRSGSLQMPMPMKASLMEDPSIGMTRSIQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNI0</accession>
    <name>A0A2G8RNI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNI0"/>
    <dbReference type="OrthoDB" id="2798901at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="127" mass="14283" checksum="428754B4F3672DBA" modified="2018-01-31" version="1">MDSPHRMKDYMDSPPRIQDYMDLPPVIQDNTDSHPTIQDVMDPPPAFQGDVVGPPVIQGDMIAPRSEFLPIELIEEVIDRASHDPESLRALSLLCKDLLTRARVHLFTGIAIRTVEQMDTSHPLQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNM9</accession>
    <name>A0A2G8RNM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNM9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="12778" checksum="CA0A229D825A39E8" modified="2018-01-31" version="1">MATLTRTRPTFQAAEESSDAEHHRPLHLDIPTPFPNVRRLEGSSSSNTPQDVATTPSMGEMEVGQAAGSAAAVEGSRAEATETETDMASASEELATNMGECSPRCGYLLPSMLVRNDLSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPP8</accession>
    <name>A0A2G8RPP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleotide reductase large subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPP8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPP8"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleotide reductase large subunit C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="447" mass="49260" checksum="AA43C47DD50CC000" modified="2018-01-31" version="1">MRRLQTDDYWSLFNPVQAGSLNDLYSNSFDSAYTEYERNGIASDRMPARTLWNLITDAIRDSSFPFIMFSDNVNARNNQMHIGLVKASSPSAALAQFSSTIDTAVAPSATLCLTRYIRVDGTLDYDELHRVAKAVVRSLDRTIDVTNYPTTDAAVSAYRTRSIALGTQGLADVFSSLEIPFTSDRARALNKRIFETIYHAALEGSSELADSLTPYDAWIGSPAEQGIFQVDMWHADTSEHYNFDALRERIHRTGLRNSVITSQMSTTSTAHLFSNSAGVDPYPSNVLRFPILGCDTTEVVRPLVNALQKRGLWTDQIRADILASDGSVQSISSIPDDLKVVFLTAYELDQHDVISIAADRAPFIDQSQSHTLFVPTLTPTLLMDLQLHAWRIGLKTGAYYVQSNLPTDSLPFIPTNPSPPFSLPPAVQPVSAVSSVNATSVSHAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ26</accession>
    <name>A0A2G8RQ26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ26"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="12195" checksum="80EE420BFDB934D7" modified="2018-01-31" version="1">MIWNRRGREDGRVAGMEGTRRTTGREILVRQKSSRRFATGDRRFDAIWVTCWAVAHFERRTLQRCRAACFHRAAEWLWGVWQMFARGPGCWMEMLGYVVEAGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQI0</accession>
    <name>A0A2G8RQI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13513</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQI0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQI0"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="299" mass="33774" checksum="57E157D94FAA5E15" modified="2018-01-31" version="1">MPKGRNNTRKTPVTSSAPSDHSSLPSGSSNRPQVTRTIIRRFHVLIKRQTQLQQLLQDGTAKKRNQALTSAKAELANIEREIHDLGGLAAYQRMSTIGQGKDRGGGSEKVLIGWLRQLGLPEELKCKGTKLCLLEVGALKPDNYASCHAWVDVTPIDLHSQHPNILEQDFLLMDPEEHREKWGAISLSLVLNFVPDAKDRGRMLRLAHSMLHSGGLLFVALPLPCILNSRYTTAEHYESLMVAVGFEKLQSRWKEGGKMAYWLFRRVDRTPSTTYQDHVLYEKKIVFRTGDRNNFVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQL9</accession>
    <name>A0A2G8RQL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_13555</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQL9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQL9"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="92"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="334"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL23804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="642" mass="73236" checksum="1582CF151602EB62" modified="2018-01-31" version="1">MAPHADPYGNARSNLPMPSTIKKPSHGHGRMSLAGPAIRAPYPMPPPSNPRQSLMRSQNVNPLLQSASKPPAYGRTPMHNNIRRGSMWQGGNQAAAPPSSQTKDTRPLRDRSFQAKMRQDVGTYLMNTGFDVVPQMLQNITGKDFRAVFQHLVTCLDPLWPFELEIRFEDHFMQALRAMKYPYVGQIDMKWLPTPAAMHSWPALLGMLHWLAELGKARGQYMTSGHPSLQDPTLVPDEFDDNNHHLALALDHNTTAYEVFLQGRDVFPEEEKLLEERYARKDSRVLSDLEQRREKLLEIQTEWEQLKKSAPPFEELKKDNGSLKRDKLKFEEILRRFEERKQKWLRQVQDEKTELEYNLADLEKIRAEEERLLGIVKEQNLSPEEVLRMNTDHQNLTRELESLKHKKHEISQVVVRLEVSLTRKVSDAEEALDQYTSLLSTLGLFPPMAPPLEDVDLTIDLHSAAANPSGLLTGADIRKVVKPTLNRIAEMKMTSRADVESERIRVDDELDQLTLECETVEEEVLEVMNKTNTLNDQADELREARIPFIRAAAQQEALVSNAEASRLERDLAAARTAAMANGVGVKSRLQALQIAYREQVEKVNRLKEDTVRAVIKNSSDIVAFKDEVSKQLQYLRDFAEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSL5</accession>
    <name>A0A2G8RSL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSL5"/>
    <dbReference type="OrthoDB" id="2745769at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59414" checksum="FE0F8D417E216892" modified="2018-01-31" version="1">MNFLQAEELSALMCTCRLFSDIGLQPLCMRSGGALRTPKQLISLLEFLRVGTQHTRAPLIKDVHFCLEEHRVPQDKASYFELHLREPAYFSASSNPLYEEHLLRASRNQALEAFLVVLQHCCELRRLQIDHWFEDVPTVPLYHAISNLTALEELRMPMVPRSRWYGDFKLASPSLRKLVLRPGRWHEIPDALTLLQPLSSTLVELDIPVCRWTRPRAPFPNVRRLAIEFPASEDVVFDLVHAFPDLTHLSLGGTRNFHLCHALSSRAEEDRLREHSQYQWHALASTPTPIPPWPSLVAVHAASACALYTLALPCKVPRVSVTYASGDPAEDMLPRILADTSPTCLEIRVAQAHYRYTPLPRRFTGLRPGDATASLERVVLTVDGAAVPDYVKVSGLLVDELKEALAPLRVTHVLVQHALSHFPAARAHTRTVVRTLCADARRRADALARAVPALRWVGVRVCVLGGPAWLYCWAVERHGAGRPQGVGVFGEANVQFGLTEVGAGVGLREMSEEEGWEVLRAEEMEEFAGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTE1</accession>
    <name>A0A2G8RTE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTE1"/>
    <dbReference type="OrthoDB" id="2797179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="307" mass="33571" checksum="6759F9DEEDE5E18D" modified="2018-01-31" version="1">MLTASQPTMPSIASGDDLAPLFARIASLARLGPPSRPCITLLSQLQPSVNAILATLSPTDAEIFRSVLDDVPLISHTPAFAKQPLPLPQRRLPCLLGPPRRVRRLPAREERPPHPRKSHPQLRVHLTLTDHPAHAVQAGAADLHFAARAALHFTPGELDEGMRFVRMVCACTCTVFAPLVAFRHACAAALAPLIDLGPPLTCALGEYAWTWRTCAKCAHHTGRGKCGMFCADAPWFVELWRELVAILRARPDPDAVLIWGKEHFSRALQKAMACPICVNVAEEHLKCFKGLLVVEAAKRIAEIPLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTI7</accession>
    <name>A0A2G8RTI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTI7"/>
    <dbReference type="OrthoDB" id="3357985at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="242"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="569" mass="62089" checksum="C1D031C4B67DF81A" modified="2018-01-31" version="1">MTADATQAGEQLQAPTAREAEAPFNREDADFVLRTADGVHFRVFRTILMLASGGFAGMLDVPQPPTAAGSEETETPGVDVSEDSETMDTFLRICYPHVASDIEVGSLSHLRKVLKAGQKYDAAPVVDVMRRALVQPRFIDDNPLVVFAIACRLDLEEEAKEAAKVAVMKNRVKDETPCPEMDDVGAGAYYRLMLLNQTRLTLRATIQIDFNGIGTFCRNAPPDPDPETTIDSVSQPFTDADADVVLLTSDSLEFRIHSKIIELASPNMFNMLTQDPSATEQRVYIMNESSAVADPLLRFCYPGPRPLFPDAPNTFLRVLAALQKYGLTGALDDAVRAHWAAFAATDPFRFFFHAVALGRASEARACARLVAESDGAQSMHTLYVPEMEGVGSLAYRRLLAYVKRFREAATQGFQLSGFRARPCVDDRGASPMPCPCRTRCPLVVSTRPPAAGFEGVIKEIKSRLEKRPTGRVLAGDVGLVGAVLDAMHAQRQEMAGLPISASNFMDRHAQWTSSSSLNSPYIPPLPTPEFQCTMSAQVDWASSLLQCYADAVDGAVSQVQLDLSNVITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTN7</accession>
    <name>A0A2G8RTN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTN7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTN7"/>
    <dbReference type="OrthoDB" id="21643at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="430" mass="47114" checksum="8CD31B6304976DDF" modified="2018-01-31" version="1">MKRRRLRGVQGVHAHDMSLVTPENVATRGGWRVTPTGRLIRPMRMRPLHPLPELVVGAQSLMKSKEKGKEKGKSEKEKKSRKRVRNPPTRARRKTIDPTKYGSQHLKGIFLENAAAFTPPAPLHSALITEAPPGPTDEAMSSSRLESEDDSEEESSTESEVDVPPSSVTTVAKLPVVAPSPPKSAPSVPKLAAQPSTPGQDFAEEKKQSLALLQSLFDDADDWGGTESIGSDGEVENQRSSVDRQPSRQSSVSEGDMDSDLAMDVDESLTEEAAPTASAVPVREQTSGVQRMKLKDLFAPREEEGGFSLLGHLDLDLELEEEVPFDVSAPVPSIAPSQTTSAQPSAGHVSHMTTLDASRPFFFPTERAGGKRSVLDPTNWRSWFYRTDTPEAIHERWEQTRGELTAGWKRRHREAVKSRRRRGGGGGDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTU1</accession>
    <name>A0A2G8RTU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTU1"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="465" mass="50622" checksum="48AD8EBBCF285575" modified="2018-01-31" version="1">MSAIPSPADLSIDFIIVGGGIGGLAVAYVLSKAGHRVKVLEKNDLSIPGGGHRVTPNFSKILRQWIGEEELKKISVRCIGSPSFNLRDGEVVGYLAWQPAVLAETGGDFILMHHKDIIDILFKLATEAGATVELHKEVTAVQPGTDEGNKPSVTLASGEVLTADIIVGADGCKSLVREVVLEAEDCPEPGGMTLYSGVINAEDMVGDPDLEPFILSDEWAIGMGPGRSMCGHPVVGTSHRTSKKQYAFHIYSWNNLDGLPQGGEENWEELYPTENLNILAYGTAVQKAIKLTTNLVRTQWKVRRKIEEWVDATGRIVLLGDAAHPSFPGGTHGSSMAVEDAVVLGSLFSHLSIMDQIPSFLDAYQELRQRRCDLVKGADVANARMVTLPDGPEAVKRDSDMRGRNDDWGDEGALKAQFEEIAEIFVYDAGDAAEEWWVNWGRFSTTAREQPNMMNFFSGITMLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUF5</accession>
    <name>A0A2G8RUF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUF5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUF5"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000070">
        <property type="entry name" value="Endoplasmic reticulum protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="136"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="190"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="443" mass="47845" checksum="A1927FF2A1019102" modified="2018-01-31" version="1">MESNKDEALKCLAIAQKHRNAGNYPSAKRFCQKSLSLFSTAEAAKLLEIIESEAKDAETSGSGSGSQQSGASASASTSAAETHPSAAGARHRHTQSTADGKAPANGDASGAKASQKSYTPENLAVVNRVRACKVTDYYEILSLKRDCEEAAVKKAYRKLALALHPDKNGAPGADEAFKMVSKAFQILSDPQKRASYDEHGSDPESRFSGMSSSGPSFDRGPGFGGGQFEGEISPEELFNMFFGGGGMGMNGGSFGGGPFGGPMFTASFGPGGFRTTRMRANPGAQQQRPEEPRSIWMQLMPLFLLFAFSLLNALPNLFSTPVTPDPRFSFSPSSRYNVERTTGGLHVKYHVNAAEFSGHPIAAELARNDNQAGPQLQQFETNVERAYTNELYGQCQRGLDRKQRRKDQEVGVFGIGTDWEEVKKIDVEPIESCDKLRELGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUL1</accession>
    <name>A0A2G8RUL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUL1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="135" mass="14161" checksum="C231E3D7EFDD395F" modified="2018-01-31" version="1">MPDPSSGPATGGAPRFPLQSRSLSYSFTEPPSRPLTPLYSFPPVQVTEPHTQLRSSAFFSTSEPFAPEELFLSPPPVATGPSASPSVAGPTPTAPPPGLPHFTSFMQSTAAGSAFRPRYDYGTPLPVSPHVTAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUQ1</accession>
    <name>A0A2G8RUQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUQ1"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="162" mass="17944" checksum="1EE59FCF0C8BD031" modified="2018-01-31" version="1">MSSSTLSATDICCVLFSRGDGSFHWAIVVPSSTSNMADVFHARNPEGFWEFEQTKVDVSNSKHVCVVVKIGTVTSTDTVGRILQLVQNIPMGIPAFEVGRVELTFTCRVWFKQAIRVLHANGILSCPNVYALEQELVLYGRAQDRKTRSGLGYKYHVASTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVE1</accession>
    <name>A0A2G8RVE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVE1"/>
    <dbReference type="OrthoDB" id="2804412at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="743" mass="81245" checksum="069E6EB49191686B" modified="2018-01-31" version="1">MGVACEVYTKLLFKRGHGHPLWEPEPTQSGEVLIGDVGYMLDGGFYRLFNTTLPADHPLNERHGVPDGYEPLTLPETLRHHRPHALQAGPICSKSVTAVSADASMEAGTGTIGPLAHIRFKFSDEQGAVLVLKNDAHREVLHPCRDLTQYILLNHAGWHQFARNVCRLDLKSQDIIFVCGWVKTAEWALAAATHRARDGEIAFGGDFGPAGQASFSVSATHEVSMSWEHRRGPNGTQGEGEKASNFDQCVFLHYYKVKHRPFFVPKVLRAATEEEHSSRSSTPNGSDYMESVEDGCAISGSGDASFESETSRIEVVPRPSEQPDMVNTMLDYILDQTDATCAIVSDRDIAMLSSQQGQVDMLENLSQLLADNRPNLTVTGGVGMLPCHNAPIDGATLPHNEHLTIPPMVQFVAGPPRVLPHHRAWSKSVSASRSRRSRSRSHSVARAPSSSSAPAKPSLSQPNESLAIPSLAQLQARISHTISISQPTPVPVPVPVPIHWSHEIAAPLRPRLKLNFRSQSSASVAEGPHERQRSLPRSLSLAAACDLTSTGAEWDWDESSAWLAHPGYISRPELTGEDEDLFPLDIDEVSWQQQQQHEGSFDAPAPGPSPLTPMAGVEGQFSMDVARVENLSLPAQHRFSQPPREEKVSALLESSSTAKAKQGSGRNAKKTSRKMKVTACKRKVTSGKEAASSPRGKEKGKGKGKETTRKRARSPSVQVYSINEDEQEPEDERPTKRARQQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVP9</accession>
    <name>A0A2G8RVP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVP9"/>
    <dbReference type="SMR" id="A0A2G8RVP9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVP9"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="322" mass="36474" checksum="B2C1052F9FEE7FA9" modified="2018-01-31" version="1">MLSTLPPPASGVHHPLITTTKETEDPLSEVKVLISDFLDRSNYKSPQSPCDLELRKKITEELSTWPSDINPTAISKIIDGCCVFVETAYGHTTHEHRCFIAFYIAFCIYIDDLGERDLDAIKLFTSRLVKGETQPDPILRRLAEHLGCVYDLWTPFGADAIIAGTLDAITATYLEFTTQEMVVKPSATRFPYYLRTRAGLGPPAIHFLFMKDWRATPESYLQIIPDMEHWTLGTNDILSFYKEELAGERNNYVHLRASAEQSSAANVLRQLVEEVLESAAKIDALTSEDPELAALWKRYQQGYLEFSLKAQRYRLAELGYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW34</accession>
    <name>A0A2G8RW34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW34"/>
    <dbReference type="OrthoDB" id="2754443at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64463" checksum="510E12D15486A574" modified="2018-01-31" version="1">MAPRVYTMRQGSFFRPLEWRWLNNAVLDTDVQEWLAKKDYPNARAVLVDGFHRNFTTPAEGETDEAFKKRRRGAKKSRKENIVRIRAESEEEFQTRMQNLPDHIGVWLANWRHRRARQGGKRWQPQTVPLPVKRKPRTITPFDAYCKTGPAPKGSDYADKRCNLGELRAARKAAWDKLSPDEQDNYRTVAVALMVKQEGFSEVVTEDGEDVTQEAVAHAEDIAAHVDGIVKGLHESVGWGGIAIFGGPDENGEGRMHITGVGTNRHGDTFLDVLLNHIGWTPLEFDTLFSLWVEQCRDGPQTAPNPMNTATARRAMDYIHREGPTGCAGNTPPYTAAVSLASDALANWETAPPPVFPLPVSNYGELDEASRRQHLLSNALHHLSLTTRREPSTSPAPFTADPILLSAFDTTNAGGGTSETTTPHDDPPALEMNGEGDAPDFPPPDVTPGVGEAPSVFASNVNYDPMCMDLECRLDVEHSDIPIHVHTPRPDCHGPTVLRAEGFNTAFEDVSELQTGQASTSQLTSLSTIESAPATSSHRNKRTEVSGVPMPGASGAAVVLRPMRARSTKSRQDTADGTLPLTAAKRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWI0</accession>
    <name>A0A2G8RWI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWI0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWI0"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="251"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="435"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL25847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="568" mass="61731" checksum="9AE77B4E72882AF3" modified="2018-01-31" version="1">MTNKKNKQARKKQQAAKAAANGSANGSANLHDKMDVEKEPIVVQDSDEEMPDLEPAPVEDDPDKIKEKGNTAFKAGRFQEAIDQYSRAIDLRPSEPTFWTNRAAAYMALKRFKPALSDCQQAAVLQSAAPQPKTLVRLARCQLSTGSTAPALSTLRSVLTIDPKNAAALQLQTRVLELEAHLRNLEGARGRNDWGMARLALDKCIQVIEGEGGDVPIQWRLWRVEIEIAKKNWDAASLAANDAMRFDSNSPDVMTVRGLLLFLTSKTAQATQHVQSALRLDPGHEAAMKLRKRIKDVERLKEEGNVAFKGGRLAEAAQKYGEALDRIGSDDREGGGGHIRAMLLSNRATTLVKLERYEDALADTEASLELNSTSFKALRTRARINLHLEKYDAAIADFNSAIEQAGFEGSDTDVRALRTELKKAEIALKRSKTKDYYKILGVERDCSDTDIRKAYRRESLKHHPDKGGDEEKFKLIVEANSILSDPQKRQRYDMGEDDDDGMGGMGGVDLSEIFAQFHGAGFGGGGRSGFSSFGGGGFGGGGFPGGGGFGGGGYGGSSFRSSGGGFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX43</accession>
    <name>A0A2G8RX43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX43"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX43"/>
    <dbReference type="OrthoDB" id="2737054at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61749" checksum="8C0D75B93A4E2E47" modified="2018-01-31" version="1">MSQNTVNFPSNCALMNYDVLLAIFDGSYYRDRRELAAFDLRNCALACRAFNEPALRALWKTMSPPKPLWHLLAPDRHPEEIISDELYKDAARWNRFQWYARFVRELEIPHHGSSAMRDAQIIRCLLNYNGRNSFTPSLRVLSYPPESIWDDSFCALFTPRLRDVTLHYTHPFRFDEHQWIRFGQSVSNVPYEEPVRRLRDSSPHLESLRLYSAGITPNLLTAITSFEHLREARLGTINSEAFRNLVAMPKLTNLEVYSLDWDEQTLACEPICARSLRSLVVGDDASTLENFFYALDAPSLEAATLHLFRDDTDAALNYVPCLSALARAVDPAIFRALALEAGYSRGPVPELSLVELLAPLFQLRALRHLDLSGTRLPLFAEDQDFMYLALAWPKLETLSISPMSQDLDDVCQVPSPVVLDHLRMFCPNLQRLRLPYLDLRGREFEIVPPPRGRARHGLVALTIGSVHRPALACEGQDEPEPDAKQIDDLAQYLLQLFPALEFPQPKQSGKVAWPCGLGDVLATSASEPTWGKVYDRCRVLREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX84</accession>
    <name>A0A2G8RX84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX84"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="124" mass="13666" checksum="0478432463E9BEC7" modified="2018-01-31" version="1">MVSPQRTSLSPQTRRQHFRKPCPSRVLRCGAALVGSLLAFVPGIWSSPPALADDRMNGMHRRMCWRTTWKEEALLCSSAGCSDPLDRDVIQYKGDVCIPGPLPVKSHTVHYDTRLHLVAGVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXH5</accession>
    <name>A0A2G8RXH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXH5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="13829" checksum="EA1F4EB09AE1EDEC" modified="2018-01-31" version="1">MLSSSSITGNLSARVMWKPAAIGILAVWKQGQKCFHIFLRSKSLYRRDTIANIHFEQVVTDTIYLFSAPLGQMSIETTTEVEVAVSSTSPEAIAQYQEKMDEVDAIFEVIAAVEEEYWGDIFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY53</accession>
    <name>A0A2G8RY53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_12174</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY53"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY53"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013916715" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="689"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL26417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="783" mass="83349" checksum="72D0F96A96C36418" modified="2018-01-31" version="1">MAKGLQRLSAFLCAIAVGPLLALGFTLPASGYAFPDCVNGPLANNTVCDATKDAVTRATALIDLWTDAELISNTVNGSPGVARLGLPAYNWWSEALHGVAQSGGVNFATSGNFSYATSFPQPILMGAAFDDALIEAVATVISTEGRAFNNFGRAGLDYWTPNVNPFKDPRWGRGQETPGEDPFHLQHYVYHLIAGLQGGIDPKPYFKVAADCKHYAAYDLDNWNGVIREGFNAIVTQQDLSEFYLPPFQTCVRDAKVASVMCSYNAVNGVPSCTNKFILQDILRDHWGFGEDRWVTADCDAVLTAYTPHNYSGDPVQIATNALLAGTDVDCGIYYAIFLPDALARGLVSSADLKRALVRQYASLVRLGYFDPPESQPYRQLGWTDVNTPETQELARTAAVEGIVLFKNDGTLPLSSSVQKIALIGPWGNATTAMLGSYVGVAPFLISPFQGAQDAGFAVESVLGTSIAGNDTSGFAAAVAAAGRADVVLFAGGLDESVEAEALDRLTVTWPGNQLDLIKELADVGKPLVVVQFGGGQVDDSSLKADDGVNAIVWAGYPGQSGGTALFDILTGKAAPAGRLPITQYPAEYVDQVPMTDMTLRPSATNPGRTYKWYSGTPIFEFGFGLHYTTFSFAWAPSAHTNASADTVARYSIAELIASGNKTAAFLDLAPLDTFSVRVTNTGNTTSDYVALLFVSGAFGPAPHPNKQLVAYTRVPGIASNESAVAQLNVTLGALARVDESGAKWLYPGTYTLALDTIGELKRTFKLVGEAAKIEDWPKDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYE0</accession>
    <name>A0A2G8RYE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYE0"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="39145" checksum="4745C13565CF89C9" modified="2018-01-31" version="1">MADPNTRPLKRARIATDGPADSQSNPSGSSISTSSSNLHRHPEIWYDDGNLVLVARETAFRIYRGLIAGQSTVFSDLFASSTSSPDETFEGCPVIHVSDSPHDLVLLLRVLLPQSRIHYHTTSANPTRTFDELSAVIRLAHKYNVSQVLEQALSSLHEFGFATSFATYSNPLPGSPLALDPWLNIAVVNLANLTDTPSLLPLALFRCAYLGGELFDGWTHEDGTVEHLSEADLRRCVDGRTTLTHEYTTFLMALFDPSTGPVCARHATCSANLRRMQHNAVCSKELALQHDALKDWVEVVREIENSGKVCRSCAGGMADRAKKGQKKIFERLPEIFGVTVEGWGTEQVATAVVAGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZT4</accession>
    <name>A0A2G8RZT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZT4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="108" mass="12211" checksum="E529289224BC0D12" modified="2018-01-31" version="1">MGPPNRPTGGSGSPRPVMSSKWWSQKPTRPGYLHEDRLKRRAVVPDEGMPPRPFTDPPDQSDGTSLPSTIGDSDVVRTRDQATRDSHWQIIAQLPVVQILYRILRNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0Z3</accession>
    <name>A0A2G8S0Z3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0Z3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0Z3"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37128" checksum="84EEAB2866A2AC9B" modified="2018-01-31" version="1">MHRPMLFSAAYSEQLERTRRETQQQAHARPQVLWRRGFHSEGGRAGWGYYLEPAPSSPEAQSSAGEESEATEGSTAVEDADVFHERAGRRRRRYARGEKSEDGVGEYGCGRRQRHVPGAHTRNTGPPAAEAESLTVSHGRRIARAIAERAKMAVKSYTLISLWFVLTIPIIFWDAGYCFFRPRSMVGGDLHWIWSPYALYQEIDYVYGLKAIEENSGFTNAQSALNIIENFMNIGYLYLTHVSGSSFAPLLGFASATMTLSKTVLYWLQEYYCGGCAVGHNDFKTLFVYWIIPNGLWLIFPTYIIWRLGSDITSALQLANRATAKTKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S152</accession>
    <name>A0A2G8S152_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S152"/>
    <dbReference type="STRING" id="1077348.A0A2G8S152"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000257">
        <property type="entry name" value="Conidiophore development protein hymA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="329" mass="38370" checksum="FC0E19D8E747AF63" modified="2018-01-31" version="1">MNFFKTKPRTPPDLVRGLRDALPKLEAGPPGGEVRRKANEEVAKNLQQIKAILYGDGDPLPELVAQLAQETYSTDLLFHLLQNIHKLEFESRKDVVQIFNNLLRRQIGSRFPTVEYLNSKPEVLFAAFDGYANEEIALNTGMILREMLRHEPLAKSLLYSDQFYKFPHYIETTTFGISCDAYTNLKETLTRHKTMVAEYLDKNYDRFFSSFTTLILSNNYVTKRQSLKLLGEILLDRANFAVMTRYIASETNLKMMMNLLRDKSKNIQFEAFHVFKVFVANPKKPPQIEGILRRNKDKLLKFLKDFHNDKEDEQFMDEKQFLIVQIQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1L6</accession>
    <name>A0A2G8S1L6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10597</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1L6"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013728649" evidence="7">
        <location>
            <begin position="25"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="233"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="381" mass="42646" checksum="6070F6CD784F8850" modified="2018-01-31" version="1">MYRLLLELAFGLLALTVLGISASADPPAPVWLGSLAKQCRFKLGQTTYDLCPIVEGNEGGWTIEFDRKTPPTVTKTVYRIDLRKPLERDANVPGEEQCPEGTWICQTISNRRPRHDGENPRVLQVIPVAGAMHLPNETHYRPGVNVTAQLTPAREDSKSKHFRNVPPIAIELMEAQLRAAMVLHVRLHGGHYMYAPQKADFQFLCDPNRDEPSSPAYAWFWNGTHTFQWRTKHACGSQRAVPPPADKPPSGGVGDEDQDMPPSDDESELRNGFPFSGSISRTRMILFLSSCTAIATLAYLAWRPPARIRQYVSRFVKAHPRLARFRVGERVLVRWAYEDLEMAEAVYAPGEEDTMVNGEMGEGIPLKPSPRKGQWASYGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1P2</accession>
    <name>A0A2G8S1P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1P2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="127" mass="13526" checksum="1F52387B028BDDC4" modified="2018-01-31" version="1">MVAMVELDFYVMTPRPRCTATQFRSCLLTLPTRRASHATSSHLALICSGVPMSPSMSSVMSSPMASVHAVEIPVSSGNTSDRNAATGTTHGARTTDRPTSSEYTIDSDLDLDSGAHPPRLTPLFMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3F4</accession>
    <name>A0A2G8S3F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_09595</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3F4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3F4"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL28306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="479" mass="52956" checksum="CF15E18035FE3894" modified="2018-01-31" version="1">MAVLTHPPTGWASTTTVLSISALLVHQIFRKYETFSLPFHAFLLLVPPAIVWHNCMSSASTGTGWPTAFDLAFCYAWYTGALATSVVVYRLSPFHPLHRLGYPGPVLCRTSMIWHAIRTNGGKQMEYLRSLHDMYGDIVRIGPNHLSVREASLVGPILGVSGLPKGASRAWNRGLAPAALKGYDHIMSNRVHQLVDVLGQQEGVVVLGKWINYFAYDFMSDMVFGGGSEQMKEGDTDNIWRLVEKGTEIAFHLGQLPWLGIYLGRTLTKKRIAEGSSSRDLFYYLNNEDLSGEDPPPSRHLLDDGVLAMVAGSDTSSSAITSVFHCLLAHPAAYAALQEEVDRFYPRGEDVCDTMHQRDMHYLTAVINETLRLFPPAPTSTSRQVPHDAPAPVVLGSLVLPPGTHVYVPPYVLHRDARNFAFPDAFWPERWLVAAGHMPPRIPDARLEQVTYYCMSLAATNALAIALTGALFQAMTNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3G3</accession>
    <name>A0A2G8S3G3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2729340at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058503">
        <property type="entry name" value="DUF8190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26608">
        <property type="entry name" value="DUF8190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8190" evidence="2">
        <location>
            <begin position="197"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1398" mass="159098" checksum="6BA65A404BA43FC6" modified="2018-01-31" version="1">MFDDGEGSLFSSDNEDDDDHHWQEMGMGRSGRLEDDRVEAEMGWPGIGDALYEDVQEGAGAEWTKRTHESRAVPETLAMDDDGGLDQWKVTDRILLDGIRETEPRVEYENVRTEDLPLSTLAHMWENDNADAAMALLFKKHRLTVDDRYLLPISDGNVVLAWMGAYQDYKLVIPSGIGLHAALPNLSIPEVRDDPNWNFNMHLNRRHWEFFGDRPPFGFDTAKRMVNIGETSSGDDIWMVWAPSDRLGARAQLGDALELSKEGTRMDPPTARVMMAMLGWMLQHINFSNISLVDDYPDVTSDATFRLSTDFMERRDLRFSLDAFTRLNDAIKTNYRAWVRGAPAAYRNDIVKGAVPCCIRIRYGQNRRIACDRDVGEDARYWEKDFDLPHIARIQLAIAKHYAAFEVDEWQDIMPEEIINQHRIMYTTDDEDTREEIEDLDELPLLDMQNQEIPIYNAEGKRIPRRRAVFTEDDAGLSLACGLLQDLSQVRQLFDTRTRQRRARSRLEGEPGEDHGRRTGTPEVHDGDGSRSDEKGVPLWFFPHFFSSKYGQWQADGVMNAVLPTVDKINQTLRAYEGVGMCVEPVRSQCYNTYAHETRASAKLHVAQRGMLTATVGGAWEGNQKGARTAKNLFEQTDWRMPHERLEAQTDKVTKTFLRLEEEFVFHIARFADEHQNGHAFFEQAISPLVNAGKCNDVLKRLKCTTVVFKPQIWPQLYSITTYPVTAMIRAIWNAHLRATLRDRVQLRDLSPTGTPSAEAMRLTPMPFYLEWIAVLERCLNFAYTGAAKVICYKLMNQLWAGRALRDGLMPVFSGIPRINILNWPIEKNSQRPLVASEKSLTLTYGKAHFIKYWTHLMIVRVASKPPVSTDPVKSERACLHAIALLAVDAYIEDVRALVREELGAIIDGQAHQEGSVEEANMKMRWRTFKHWSDLSEPLAWGERGETYTKLVRMVIDNENAMPDGLPVSTIDKCSLEDFVQRIFKMGTKTTLRSVQAPLVRKGASWPVLTMVIRECQKRLGEVSDASARTICSILVDAFKERKVEYVPDRLPPKPNPTIKAWTILSEAHGERTAHIDRSLQNPRERRAFQLSEHARSLSESAVNADWQAVKIPIGHYHKYLTRTTCPVDCRRDRHEQLASDVATVYNWAEHELQTNFSSWKCQLAVTLAFLVSKVLPNVHLPPTSQLAAIKAELKTVTPQHQESAIPIIRKIKFTSKDIGGSKDRKTYFTVTTLVILALIVPESPLRAKLERDGKLYPDWAAKHRAKAITTPTLIRLGVLNGHGPGLLHAAKWGQWNVRDEGHLRTWWEEITRSLQTPPHGPYHLIAKIFGATEAERQVGQGEFPGLDVIQSRAPMLGGCSTSPSSSKRSRQDSTSQSSEDEEEGDDEERRRREKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S496</accession>
    <name>A0A2G8S496_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S496"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="237" mass="25392" checksum="C810ED8B7FB1746E" modified="2018-01-31" version="1">MSTTTAFSPSGPIACAHVPVVRAAYCRDQNAHCAGWGRRMDPSCPRCSRPGLRRSPSPSDTVSGRASGATSTSRARRTGSRFRPRIPGWRQWCSSGAPLQTGSTTPRSTAWRGSPSSTRAYPKLRSQQAPDAELPCDARATPGDTAQQPHRPSHPTPLRFHQTPGPAPPQDPPCSSDPRTNAARTFSATETETETPLPPHLPPPPPRSAPSSRVKPHPQCRHRPRPPQASAASPPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4A4</accession>
    <name>A0A2G8S4A4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_08605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4A4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4A4"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL28564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="47671" checksum="0CFBF04C0A443F72" modified="2018-01-31" version="1">MQSYKASFPQLDLTGDRYNVALSLYFLSYNVCAIPSNLVLKKFRPSRWLPFITILWGIVTCLMGIVKDYPQLVATRVCLGIAESGFAPGVFFYLSMWYPRHMLHTRFGLFWGGATLAGAFSGLLAFAISFMSGTAGLLGWSWIFIIEGMFTVVVGVVAFFVLVDFPDTARFLTPEERAYVIQRKKFDNSTVGEDEHFELRHVWEAISDWQVWLLSLINMSIITPVFGLAFFLPSIINGFGFNAAISQLLTIPPYVVATVTVVVWAIWSDRIKRRFPFVLCGQLLCLVGFAINISNASIGVKYFGTFLIVTGGYAAYPADTAWVANNLAGHYKRAVGIACQVIFGNTGGAIAGIIFRSQDAPRYILGHGVEIGFVSMGLVLMPIVLYLYTGANRQKEVKLRQLDESGEKYTAGQLRRMGDRAPDFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4G8</accession>
    <name>A0A2G8S4G8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4G8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4G8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="182"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="248" mass="28977" checksum="5287995F32AA0D74" modified="2018-01-31" version="1">MYCSRHRDDWVKWLPIAEFAFNSHVHSATGYLPFYLMYGFEPQFHIPMLSTAVPSADERREELRQAREDATSALTLAAEWMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVPEVSRKLVDRYAGPYLVKCKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESRRYGRWKKLQYLVHWMGWGPEHDSWEDAADLANAPKVVQKFHSTHPDAPSPLNKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4J8</accession>
    <name>A0A2G8S4J8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4J8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="140" mass="14495" checksum="70B18C8AF2261FF9" modified="2018-01-31" version="1">MPLVDHGWGYSDGNVVDTVTYGHSDPWYTHTYAYTWSSQAVTLPSDGVGQAQADTTRTTSTTTHRRAALSPTRSPTQSPTSTTPAASQASTTPPTAHATSLADEGMSASASGSGGGPGYYTGSRGLKLELDWGGGSNRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4M8</accession>
    <name>A0A2G8S4M8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4M8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="94" mass="10502" checksum="D429BF2B9E765411" modified="2018-01-31" version="1">MHPLRSFGTEWEKKMKRENKHKHKKRLLVDADVELHNNTKAVDEGINQKSAEGTADSMKGRSVPLNHATGSDASYPMPEIGPKTEVAEVKPSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4R6</accession>
    <name>A0A2G8S4R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4R6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4R6"/>
    <dbReference type="OrthoDB" id="2750550at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="47880" checksum="29042A2A63793F42" modified="2018-01-31" version="1">MPRPDVPNLPVHQPKIQLGVGTRCLCAVTAVASFLVDVLITAADFLKVPLAVCVAFVVGSYIGAAVVRIVLGSTPGNAIAFLSASAQNASQSITFFVQSALGLKEGLRVCVEASLETAMTTICLLPLASRFAQCNITKVTDSIPLAHADYPTLMEVQGRAMDTLLVQSQTGLSLAVDVKHAEVAIKDLVVVVNASGITNLNRDLLVAALRDFVVDSKASGRALQKLSSKIYSAMDTSVNPSAIIYYYVANRAISVIAFDEYALRAIEGARASKTQDVQITLLRSFEAVAKLLSTQVTSILVEATRTMATLDVLEGHLSRVQALCVEEDLVASISRGSLLSELWTALGGNKGRLLDLERRATVLQNVDIYRRLAVAHVTATMQTLLAVEEELSLLIQKLSNPEIIGSEIPLEVHVASIHLGVQRFQDERLKVRVGNGNGAIMMRTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5B9</accession>
    <name>A0A2G8S5B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5B9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5B9"/>
    <dbReference type="OrthoDB" id="3178264at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013956880" evidence="1">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="16324" checksum="4C62BCE931D39905" modified="2018-01-31" version="1">MARIFATAGLFAYVAFAASLLANGAPARRQLGNLECNIDRAEIVFHVAQFAGIVNTLGNNTHLIAANKTVKHDVMTLQTGAQGAGEAIKQIIIALVNGEKADPNLRDQVGGNLTAVHEALVDLSSKDNSTLAVLDTANEEFVNSVNAANGVVNNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S615</accession>
    <name>A0A2G8S615_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S615"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="143" mass="14671" checksum="235E6AC8C3607A8C" modified="2018-01-31" version="1">MLCLWAQLAHSSCIFVPAENRENGGGHAGLTRLVGSSTGGVTTTTCPSRRASSPTRSRPSGNGWPRTSSRVTSSTATADSPSTSSTGPSPSRLATESTPGRRATTSGKTAKPLMSSVMARTKPERDRTSLGSTGATFVCRAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6E2</accession>
    <name>A0A2G8S6E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_09358</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6E2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6E2"/>
    <dbReference type="OrthoDB" id="3255500at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL29307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="264" mass="29512" checksum="B381D8E13541A23E" modified="2018-01-31" version="1">MDITYGLDVVGADNRFISLLADFAEAFQSAFSPGKYLVETFPILRHVPPWFPGATFHQDAALYKKSFSAMRDEPFDKTLDNMVDASLQVFFLAMVLHPEAQKQAQAELDGVIDPDRLPQMTDLESLPYIQALILEVLRWRPIIGLGFPHVSRSDDVLRGYKIPKGSLIFPSSWAISRDPQMYPDADSFVPGRFLRDGVLNTDVLDPRLYAFGHGRRICPGRHFAEASLFLTVASVLHTFTIKPRCNAAGEPVLPEGKMKPGFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6I1</accession>
    <name>A0A2G8S6I1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_09395</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6I1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6I1"/>
    <dbReference type="OrthoDB" id="3061254at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL29344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="278" mass="32367" checksum="A25DE2CD4BE0CF2F" modified="2018-01-31" version="1">MPSQSHPIDYRRASKPFELIHVDLKSFPVPSYHKYQHEILLYDDYSSYAWSISLRTKDNALQSTRQWFSYVETQYGAKVIKWKSDSGGELKSHAFTNMLKDKGIEIIPSAPHIHQRNGRAERIIRTLMDKSEAMRHDACIPQSWWEFSFEHAAHLHNRTPTRRLEWRTPYELLNGTKPDISHLRVFGCGAYVFLPPEVRKNKLSPKSELMIYLGVGAGNHNHKFMRLPNNVIFTAAQALFDESLFPKCSHEKKRQGQQSAPEPVEPVDIWTPVKRCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6J1</accession>
    <name>A0A2G8S6J1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_09433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CNEP1R1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6J1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6J1"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019168">
        <property type="entry name" value="NEP1-R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20996:SF1">
        <property type="entry name" value="NUCLEAR ENVELOPE PHOSPHATASE-REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="174"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="277"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL29381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="394" mass="43780" checksum="558E2A37864CF4C1" modified="2018-01-31" version="1">MPPRPPPLHLPAGSFYPPSDAATFRDLLLFEERLKTNAASLNRRKRRYQLFLSQLLLIIGFLLCEVLLQTNWLGVPYKWVLHQTLPEIYPGDADVRVHPYFASGLLFVSVTTLVLFFASGMYSEKIGYANKYVPQANRALRNFNMYLNVRQPPLRSKLPFNPFTFLFARPHSPPLPASPPLPTTPHPPRRRSRSPSPSSTPGATSRRSSSVPIQPIPPASNPRGELIFSSRVDRGFREPYDRYRAQFERRREEREWAAYGQTWRGWLHRKMPWTRRASTPTAALEKGEKGGSSSGAATPMTPREPGGVEEDEPGAGAGDTEWEEGLGRIGAGGEEWEGGGWDGYTARARDAASVGIGDREWGGHASVKCGLCDVFMSCFRVLSAIEDAACAGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S864</accession>
    <name>A0A2G8S864_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_07880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S864"/>
    <dbReference type="STRING" id="1077348.A0A2G8S864"/>
    <dbReference type="OrthoDB" id="3051303at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="81"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="615"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL29969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="828" mass="95727" checksum="2D8482FFBFC7440D" modified="2018-01-31" version="1">MEIAIEQNKAKKEQTFEEMVPEQYRDFRDVFDEAMFSTLPERRPYDHAIELTDNAKLYCGKLYPMTRDEQQALDAFLEENLSTGRIRQSKSPWGALFFFVKKKDGKLHPVQDYRQLNTMTKKNVYLLPLMQEILDRLKGAQYYTKLDIRWGYNNIRIVEGDEEKAAFITNRGLYEPLVMFFGLTNSPATFQTMMNLVFQDLILCGKVIVYLDDIIICTSDLDEHRRIVRQVLQILRDNHLMCKPQKCEFETQETEYLGHIISPGKIRMDPGKIKGVTDWPIPTCKRDVQSFLGFANFYRRFIKDFSKIAGPLNRLTGLSEWTWTSEHQLAFEGIKHTITSAPVLAIPNDTDPFKVECDASNFAIGAELSQCQNGLWKPIAFLSHSLSPAQKGYEIWDREMLSVITALQEWRHFLQNAREFEIHNDHKNLEYFRKPQRLNARQARWSTLLSNYHFKLHHKPGRNMGKVDALSRRVDHETGPVVEDVTLLKAHWFAASHTVDGADNLKDMCLKHIKLYDRSVVEKLGKDNDWELAEDGLIYRRGKMVIPNHPELRGRVIASHHDSIAAGHPGAAKTQDLIMRSYWWPTIRKDVIKYVTGCITCQRVKIDCQPRAAPLNPNPIPDQNWQFVTMDYMTGLPECNGHNAILVFVDMKSKDYIAIPCSKTLDSEGQARLFIKHVVVPHSLPKRIWSDRGPTLVSSFTKEVYCQMGIEGNPSTAYHPQTDGQTECMNQEIQTYLRIFINHKQDDWVEWLPLAEFAYRCRVHASTGMSPFFMTHGHEPNAGVETLKDGINESAKQFAERMQRIGKQAAQALEIAQEAMKRHYNKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8E1</accession>
    <name>A0A2G8S8E1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08004</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8E1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8E1"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="452" mass="48697" checksum="1A8DE96613EAF0CA" modified="2018-01-31" version="1">MSEPSPAHPHMSDLILAANAGSSSLKISLFKRSDSASGPPDDVVQLLLTSAITNISAPPARFSFALAGHEAKSSKESVQSIDDHASAFAHFLDYLQRQASIDRSQIVHVCHRVVHGGDYFEPVVITEESYHHIEKLSDLAPLHNGGALSVIKACIEALPGANSIAYFDTSFHRSMPEHISMYAIRQDVAKRRGLKKYGFHGLSYASILGAVSTHLNKDPSDTNLIAMHLGSGASICAIARGKSLDTSMGLTPVSGLPGATRSGAIDPSLIFHYTNRAGRISHDRALAVDVHVTEAEEILNKRSGWAALTGTTDFGQVVRWMKEVQEKAKRGEEVTEDDKKWGRAFDLFLDRILEFLGGYYLKLEGKVDALVFAGGIGEGSVELREAVIRKAACLGFELDGDMNATVDGDNGVVVDIGKSKDGRQVVVCRTDEQLEMAKDFTGPNVTVDLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Z7</accession>
    <name>A0A2G8S8Z7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Z7"/>
    <dbReference type="OrthoDB" id="3248728at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="338" mass="36915" checksum="CEB2B344BD478548" modified="2018-01-31" version="1">MYPSPPPTPATYSSDTDIQIVLEFLDQLIATLDPQDAESLEAIQLAQALAATISPDTVLQNMKRAQARVEMDAAVRWLAFKPGGKERARVRGCASAVETGAEDDCLALETTKELLRLALGHVSRSTEGGCRLVADILFLHVAALLTPKGRSEPGPHSVYVVPDVPLDTVQLDAPANNVNPNPNPKFGGLADYVLAKYPLPAGVALPSPGDWLKPEWYRTRGSVNIFVARTRVRLEDGVLQCVLAAASWCKFAGEEVMRGGVTTGDDWVFFAYRRGGQNPSRSARACYARTEVFHVGEDLENLDWILGVLIDWVENAKSFEHFEHFDVGDVPSEVEMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S961</accession>
    <name>A0A2G8S961_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07665</name>
        <name evidence="3" type="ORF">GSI_07770</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S961"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="234" mass="25324" checksum="9CFC8E2CE818186B" modified="2018-01-31" version="1">MADGLREAPPPLTLGGTRTALAFDARIRASALRFTSESDPRPMSGLVVRSPVGAAPPRTPVVPRSQRSRAPSSTSPRHASIRFNRPHPQPYQLPDSPNGEHERIHTATDPAHPGAVRLWSLTMVHGSWRASGQSPAWRCFSRLRSTLANEDPPRGSRTPPSGVHEVFGLSFAGSRFISEQNQAARHSGPRMLGIPLTSLAGFRLSSSWTSPSSLSASRHDVGPYTRALHALCVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S976</accession>
    <name>A0A2G8S976_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07496</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S976"/>
    <dbReference type="STRING" id="1077348.A0A2G8S976"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="160"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="561" mass="62764" checksum="E7923031AC3217FA" modified="2018-01-31" version="1">MAVEEHQLTQSTQQSTQPTQDASQDRSIVNAEIWGSLIPFNHANPYITRIDFLKTQTTYTMGRSRQPGVNDVPFPKCLKMKWDGEETASSAVIVTDLNSSNGTFINGQNVGLGKCKLLRDWNIISFSPPRDRDDPKDDYRFIFRHRAAKESPTDSLHQFYDIDHGIGSGAFATVVKALHLTERKWYAIKSFPGERVQQFLSWPSRRAEMMESTWKHLEREMRVLKRLRHRNICQLKETFMEPGYSISIVLEYVAGGDLNAYVNERDVVFEIEAQHITYQICEALIYIHSMGVVHRDLKPENVLLTQDSPPVVKVADFGLAKVMDSLSIMHTKCGTPGFVAPEIMGTDGYDKAVDSWSLGVLVFVMLTKNHPFHHDASSTADWKLLQEYNITPDCEDFLRKLLELNPRERMTPNDARAHVWLAAQAAKERVRSIEGELSRRSVASQPPLPKPKKRPRPPPPALSLLGCATDAGPSRAGAKRKASVLGLGRTLSTLSVADMEKPPAKRARAEPGGEENAGSAETIVPGLYRPTPPPRVVWTTESLDGEEIPGLGMWRDSSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9F5</accession>
    <name>A0A2G8S9F5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9F5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9F5"/>
    <dbReference type="OrthoDB" id="3267422at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="281" mass="29242" checksum="4A40AACF69EF57AD" modified="2018-01-31" version="1">MPMFQCRRQAAWPWCGVVVALRLELIAIAVLLLFLIEARADVNITLSDDASQITYSPPACGLTLSSAGAGNCTSSWQIVTSNASSGGTLTTTFGANNASGGLIPQLFLTVRALGLSIRTSNDSTAVVNISVSTTTPVVSVTSQFNSSIQPIRIIGLVEDRLTTLALTFEESNRTTLLGIDSIIVTVSDNNTTPFVSPSAPASTPLPTVTPSIIIPTPSSLSRSGQRPGDVAAEVLGALLGAALLVTGAVLVLLFYRKRKRKSAASQGPDPPEIPPQDIPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9U4</accession>
    <name>A0A2G8S9U4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9U4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9U4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15001" checksum="371387F487846C74" modified="2018-01-31" version="1">MPSSSAKPETWVISSDPAEAILLKHFAGWRKWLLNPHRLLRRVRRYSRPLWTLHIGHSWIYTPEVTIIGDTAHLMNRFSGTGINMALLEGLELSLALGLHETGKLGDAGAIAATITAFEESIDQAEVKMMANGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA96</accession>
    <name>A0A2G8SA96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA96"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="124" mass="13459" checksum="4B48D624633A82E0" modified="2018-01-31" version="1">MSESKEARDTRGFIDGIASQLIVGPEIDEGCGASDSVLGGVADSITGERTIDAVRERVKARDGGSSHRNGGKKGSKASNAVRHPDRQEAEEKVKNPHREVTDPLILTENVTAKEKRRETRTSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAF1</accession>
    <name>A0A2G8SAF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAF1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAF1"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="117" mass="12757" checksum="C4C990BB4012AE5D" modified="2018-01-31" version="1">MSSPPVATAALPARSTPPTENVERLKALLRKTLRVSVTDGRVFLGTFAGTDRQLNILLINTDEYRLGADAGADGLDGRYVGQVMIPWRLVLRVESHAEGDGTRNTGYFDSDEDSMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAL7</accession>
    <name>A0A2G8SAL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06967</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAL7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAL7"/>
    <dbReference type="OrthoDB" id="1918363at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="865" mass="96638" checksum="102A7156FB95747D" modified="2018-01-31" version="1">MASDLSALLNASKALTSHLSRPDLPSVNLSLDQIEAQSRRLVSRQPGTSADTSRANYLLAQAHVDASALANSIAHLNTQSTFSPLQALQDTDVAGYLRHAHEQNLISTIEEGRRETQEEFYRVLEDRGRRDWEARKKRVFEQLGARVGGENRAVTELKKSAHGKNLLSASIGLSPNIQMQSKMMAYDRVVSDLNSARLRGTSFPIIHGLRAAAASTDNPQKFNQIMQNFHVLAKIVGEQPQLPPVSHAGAHILNTPLMERKHARAYLGDPESREAVELRKQIARGARHALEEQYFDVVQRTIQTRATEARLGGDPSVANKIRAYLLVRHYQNGAWEDKIELVAGQPLWAKLFYLVRTGHVAEAVEEATRYQTAIENRESSFLSHLRAWVDSPDRRLPKPHRDQLHAAYNAHMLHSSTADPFKLALYKLMGKIDPTRRSVAQVTVTTEDWLWFQLSMVDEEEFGGLRGLAEVLLNYGEQHFDGVPGQKGTKRGIWAGVLLMCGQFERAVAALWDHHETEVEAVHLAIALAYHGLLRVPSRAETSDITPLTLSPTSPPALSLSTLIWRYVRQFVRMDAREALQYVYCVCLSADQLGGIGKEQVENAWELVRRIIVLANTGAAWEELVGGFRPDGTRFSGAIEQSAPLLQLEGLREYNDHILIRAAKSSSEADRIPEAIKLYNLAGDYSTVIVVLAHALGNTIAQPSVDEKARAIEKTAADILRHYERTNRAVGKERDAVIRLLRVREAMDAKDTGRVDTALELMESTDLVPMDGDVAKITKRAEEFRELPDALQRNLQTFLTLTMDILAAVHQKVKNSSLPDVLRQSTLVSLRKKSRSLIIFAGNLKYRMSPDVYSYLARLDVEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBI8</accession>
    <name>A0A2G8SBI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBI8"/>
    <dbReference type="OrthoDB" id="2735574at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="449" mass="51324" checksum="B99810DA46FED57C" modified="2018-01-31" version="1">MNESDFHTITDRLVDIVKAAIHLQYADLQTSISKSVFDAVVKLTTLRELRILADYPNYQEPFLNHLAVLNSPLRSLYLSGVDFSETYIPASFLHDRLSHLAPTLEFLDLDDFRIDIFPSSVTTQFTAVRSLKLQATFAPDCDLLSVLVRLFPRLDNTLELGSLYDSVRGDDVPAFRERCQEAQQRHCWSRLNRLACHADTAYLLALRCPIRRMDIQAHLPGATQYFTETLRYYYSTHLNAWISLYRGFGALDGLFPPEVADRLTHLVLFVEVGVHHGCRSRRRNCNVIRSNRIVNRLLGAVKHLRLTHLHIVFYYSVYLPVRNTAPDADSVAHNPSGDSMDLQVIRARFVGAMPTLRYLFLTTCGQTRAGPPRWEFSNEIFSKWFASKAWHVVHDVEDLHLSESESDVGMGSCVELSGEAVERIREREDLQLSRDEEYEVRLCADSMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBJ1</accession>
    <name>A0A2G8SBJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_05832</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBJ1"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="203"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="506"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="15">
        <location>
            <begin position="864"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="134"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1055"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL31136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1090" mass="125626" checksum="EC62A8EF9BB497AE" modified="2018-01-31" version="1">MSNLDVPMEDDVLSDVVPSNIVSRQESEGVESEYDGAADGMEVDELQSEGEKDGPPSPSKLAKMQASEERQRKKQKRKADEGQLAAKRQEMDKAKISDAVKRYSYLLGQTELFKHFVDIKKARDPEYAALLDAQPKPKGRGRKKAVDKVARHRKSEKEEDEELLKDGELAVDGNDQPFVFEESPSYIKGTMRPYQLQGLNWMVSLHHNGLNGILADEMGLGKTLQTISFLSYLRHYRDTKGPHLVVVPKSTLQNWAREFARWTPDVSTVLLTGSKEERADIITTRLLPQDFDVLITSYEICLIEKSALKKFSFEYIVIDEAHRIKNVDSILSQIVRSFMSRGRLLITGTPLQNNMKELFALLNFICPEIFSDYADLESFLHKDDEMAEGDEEKSKKVVEALHKILRPFLLRRVKSDVEKNLLPKKEINIYVGLTEMQRKWYRSVLEKDIDAVNGLTGKKEGKTRLMNIVMQLRKVTCHPYLFDGAEPGPPYTTDEHLIENSGKMVILDKLLKSMKEKGSRVLIFSQMSRVLDILEDYCLFRAYKYCRIDGGTAHEDRIVAIDEYNKPDSEKFIFLLTTRAGGLGINLTSADIVVLYDSDWNPQADLQAMDRAHRIGQTKQVYVFRFITEGSVEERMLERAAQKLRLDQLVIQQGRTQATKAANKEELLEMIAHGAEHIVNSIEDLMINDDIDQIIQRGEERTHELNSKYEGLSFEDLSNFKSEASVQQWEGEDFRGNRKALQFNPLALSKRERKLNYSVDSYFKETMRAGPSKTEKPAKIPRAPKQIQMQDFQFFPPRLAELQEQEMAAHKRMNDIPAAVRDPSSEDDTADKLEEERKAAQDFIDNAEPLTEEQLREKEDLIAQGFEFWSRRDFQQFVRALETYGWTDDYELLASEIQDKTADDVAQYYPVFKKKWKELSEYPRIKSRIEEGEAKRNKRSNLEALLSKKIASVKYPMQELELNYPTTKGKVYSEEEDRYLLCRLNHYGMQAEDVYERIKKDITEFPVFRFDWFFKSRSPQELQRRCNTLLGMIEKESEGKQAEEVKTKGTKGKKRGIEQVKEEDKAEASRSSTPSTTTASGKRQPKKRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBN6</accession>
    <name>A0A2G8SBN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBN6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBN6"/>
    <dbReference type="OrthoDB" id="2757351at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="251"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="480"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="975" mass="107898" checksum="8486D57DAF90399F" modified="2018-01-31" version="1">MPPKPSQPPATDASPPSADSAAANRVQSTRPPSRTIVAAKESSLFLSIPNTLSKALTIRRRRLAKEMAWWQLELKDWFNAYLPGEDLPDNLQWTPFNVDLTSEETMYVGLRKGLQDAIETVGCHALEARSTHRYPDNTPSSDGMTTRICPDLGIYPTSRPDPDAQQSPTSSVDSTESIRVRFGSMEVPVEVKRLLVKRNAASSAGTSETPPSSSTSNPSTSLPNIASTSWGDVIMLSSEGGYAIPLSLEAHRGQLVEYVIEVFNRQHRLFVFMILFVNDRGRLLRFDRTGVSMTVEFDYTQHPEIIGKFLRRVSGSRAAMGHDPTAAPADAADEKLFRELHTRYMSQSAVGRGLKNAATDGWSVYKLSIEGRFSPDHSTAVLPTAPMSRQEYLICKPMFGNRSLSGRGTKTYIGYDLARDQVVVIKDSWRLNSANVRPEYDTYLLLNEAVRQADSSDKFNAPTLLGGGDVVVAGVEQQTQTSNPDLLTRIHFRLVLKEICRPLEDFASSSELVRVTLAALNAHSFAWVKARILHRDVSIGNILILDPNPEGLPNPQKSKGLLADWDLARTREELENPAFTQRTRSGTWPFISARLQQSGSEQPHELSDDLESFVHVLNYCALKYLPNDLSSEDYRLALFISVVYDHVRQSGGLEKGSRDKLEFLIRNRPFVQLQPHKQPLQCLLEALSELCYEHYHHIQFPPPLHPPDHLRGGTSLEVLEDNFEELGTTLVEKKNRPPPVLAISVDAASEDPPSERLLRTPATIRALPPPDPSKSPFTDHEVMGVCLLDTLRPPDDSHPAYGLSWPVGDKIQRTKPLDITPNVSVSRSSKRESAGFPSYAPFAVADPEYFVPSKRVRTTTSGSRGSGSGTSRKVQQKAPRTSADASRTRSEASPGPGPSRYIDPMALRSDGEPSGSRSTTPESEGRFDDGDDDVDNLEPDTNESDAPAAANNRPTYQYAERITDMAAELDEILFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBP4</accession>
    <name>A0A2G8SBP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBP4"/>
    <dbReference type="OrthoDB" id="2757351at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="419"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="868" mass="96118" checksum="CC8BEFC6D82E36BE" modified="2018-01-31" version="1">MSWWQLKVDDWFNTYLPGEGPPKNLRWTPFNVDLASERTMYAGLTEGLQNVIETAGCHDLEARSTYRYPDNTLSTTTGQTTRLCPDMGIYPVSRPDPDGQNSAATSVDPVELIRVRYNSMEVPVEVKHEPVKRAEASSTGTPATDSPAPSSSLPDPASLPSFPSPSETDFSISSPEGGAAVPMGLKAHCGQMMDYVIELFNRQHRLFVFMILFVNKNARLLRFDRTGASMTHEFDYTQHPEVIGKFLYHLSRSRDAMGHDPTASPANEADTTLFRALHAQYDLKSTVGRYLKDAATDGWPVYRLAIEGGFSSDEKSAVRREAPISRREFLIGRPMSVSRSLSGRGTKAHVAYDVVTKTVVVIKDSWRPNSDNIRSEYDTYLLLNNIDGEVINDIPTLLGGGDVVCQGVTQETQTPNPDLLTRIHFRLILKEVCRPLEDFVDSLELVSSISSALGAHFLAWTAAHVLHRDVSVGNILIFDQDPGNPPNPSTSRGLLADWDLAKTKDELDNPVFTQKTRSGTWPFISARLQHSGPEQRHELSDDLESFVHVLNYCALKHLPNTLSNDDVRIAKFISDVYDYVRESGGLDRGGYDKLDMLVNNKPFVQLLMAGHPLGTVLQMLSELCWQHYHHIQFRSRQSSLPPAGSREPIVFRPSPLERLRSVVNPSPTPEKILPMADPERSPFKDHGAIGNVFLWATMPPEPSKVKWPSDKIKRTKPLIVPLATSRSGKRQSGAPSYAPYSVEEPKHSAPAKRARSAATLNSRGSRGRSTRAKALKTSSRKRIRSETSPAEITDPMAMRSGAESSRSTTPESQGMLGDVEDDADMDDGLEPDAADSESDTRVAGSALSHHYAERVTDMASGLDDIRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCD2</accession>
    <name>A0A2G8SCD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCD2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCD2"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="23587" checksum="0BADDCD1D55E2A68" modified="2018-01-31" version="1">MSRYPYGLSPDITPTSTPSKLTKAQKSRARREPSGVFSLFSPPQIQQFREAFSLIDHDGDGIVGEQDLKHIFSSLGISPSRSTLDQLLADRPGDRRGSLGGMHSRGPSDDAGSDRGITFPMFLTMMGEHLYDFDAESELLAAFECFDEADSGFVKCDEIRKWLGDVGERMDEVEIDKLLKGPFTRNGQFNYREWVKVLRINTDNEEKESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDL1</accession>
    <name>A0A2G8SDL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_06546</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDL1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDL1"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="144"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL31842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="583" mass="64422" checksum="67227234D7882A73" modified="2018-01-31" version="1">MDRKASGPQTRFYPSAAQSSTSLLQPQGNDGLRPPIARSLRASASNSSIFVLPLDPAEFNGPEADDKLHNPDPTRDRRSDKGGSVLTSRGFMNLGCILILVAGIVALFAGYPLISYFTRSKPSYLGGFNLGGINASGQVPSMPGNWGIIDLDTPNDVRTKVDYVTGQKWQLIFSDEFNVDGRTFYPGDDPYWEAVDLHYWQTNNKEWYDPEAITTRNGALEITLSRKENHNLNFTGGMMSTWNKFCFTGGLVEASVMLPGYNNVQGLWPAIWAMGNLGRAGYGASLDGMWPYTYDSCDVGTLANQTLNNLPIAATAQGENDKGHGGVLSYLPGQRLSRCTCAGESHPGPVHENGEYVGRSAPEIDMFEAQVGDDDNGNKVGSVSQSGQWAPFNYQYIWRNTTDNLIIPDSTKSSLNGYRGGVYQQATSVVTQTNQQAYEFSGNQFSTYGFQYKPGFGDAYMAWISNGQVAWRLNVAGMSADNVVEINDRPIPQEPMYLIMNLGISENFGFVDYENLAFPSTLRVDWIRVYQDPDNINVGCDPKDFPTAAYIEEYIEAYTNPNLTTWVDDYKQPVPKNKYHGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEE9</accession>
    <name>A0A2G8SEE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="8">Aconitase</shortName>
            <ecNumber evidence="8">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06846</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEE9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEE9"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="9">
        <location>
            <begin position="68"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="10">
        <location>
            <begin position="605"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL32140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="813" mass="87907" checksum="9C1223039E6B94C8" modified="2018-01-31" version="1">MRQPITICPRGLVRSLSSHSSVQRRALATATSLLEKDCTSITPPYSKLLDNLAIVRKVIGQRPLTLAEKILYSHIHEPEWTLANGGIQRGETYLQLSPERVAMQDASAQMALLQFMSAGMSRCAVPASIHCDHLIQASEGADKDLQCEICEPKRSIVTNQEVFDFLESAARKYGIEFWKPGSGIIHQIVLENYAAPGMLMLADSHTPNAGGLGMLAIGVGGADAVDALTGTPWELKAPKIVGIHLTGEMNGWTTPKDLILNVAGRLTVRGGTGAILEYFGPGVLNQSCTGLATVANMGAEVGATTSTFPYTPGMRAYLQATGRAPVARAADHAASQGYLAADEGADYDEVIQIDLSRLEPTINGPFTPDLATPLSKFGTFVKEQGWKDELSAALIGSCTNSSYEDMSSVAHLAHQAKKAGLKTKVPFLATPGSEQIRATIERDQITSSLEDIGATVLANACGPCIGQWKREDKQGEENAILTSFNRNFKSRNDGNRLTMNFLASPTIVTAMAFSGKLSFNPMVDSITTPSGEPFRFSPPQGQDLPAAGFTAGETQYYPKPVPEPQPEMNVVIRPDSQRLEILAPFPSHFGESSGNERGLELPPLKVLMRVRGKCTTDHISAAGPWLKYKGHLTNISENLLITAVNDEGGEVNVAFDHDRTSGESETDTIPNVAKRFKARKQPWALVVDDNYGEGSAREHAALQPRFYGCAAIVARSFARIHETNLKKQGILPFWFVDKVDYTRIGAGDTVETVGLADLLEGKTDAIISLRVTRRDGEAFEVPVRHTMSTDQLKWLRAGSALNHIRAQLTAGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SET9</accession>
    <name>A0A2G8SET9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SET9"/>
    <dbReference type="OrthoDB" id="2764086at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="357" mass="40298" checksum="E33E5FF50E4E8932" modified="2018-01-31" version="1">MELGQAESKGSMPFAPSNELPLQSHDRMPAVDRPSYRGANMSNDDNRVRTTGTSDSAQGIPEVVGIAGASGHGMDKAVAGRDVGGQEMKQVSESPQRSSQFISSLMVLPYLFPAYGLLQLATSLEVGSSLPEWYQLIRAAVVVTAKVEDLRHARERQRPTQEFNPLAYHGGREPWVMLWLRLQPTQRRRPVALQKYMEPKDCLHYPNNTSAADWREFWPRTRETIFTVMLELRACSPFNHQDQAIAETMDSRRWSSWVVDMLWVFRQLLRILPSEEDAIMTWIKRAQEPREPETSTAALRSPAGERSGRSTAGHESVIRGQIPPATSSTPNPDFTSQRKKRPLDNSAFLFLWISHAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFB2</accession>
    <name>A0A2G8SFB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_05133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFB2"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="831"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="862"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="499"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL32431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="893" mass="101193" checksum="E4C20E3917B54363" modified="2018-01-31" version="1">MDYDAYDALLHHIFKQTQGDAWFKPSEENIHAGVCLRVDNNNFRVFPYENEYLEPFESAIRVLNPVVAVKVRSAAIHAALGTVKEDSDCIYVDNDTRIQIMDTMAFLPRADKEQCAAFIRDERVMVVWTYDLDSIIPTCRDFEEKLIKLVWTRRSAFTSLAGSAVPSTTASDEHLTEKAKTRDASGTVSEKPSTIVLAPKELKSPAKKKRSCDIFGYWKADASDIEKTAEGPSARPMRLFAPVYSGLGAALSLFFIGSGASVLLEEALLDGYWARFALMATVPFLFCVSLFFSLMIVTNITYVLGPVAQFHENSKYYSAVPPAPNKLVDENLPHVTIEMPVYKESLTETIAPSVYSLKKAMQTYARQGGTSSIFVHDDGLQLISEEERQARIAFYADHNIGWVARPPHSGAPDGFKRAGRFKKASNMNYGLALSLKMETHILALEAAEPPPEPTFTEDGVAISIEDRALEMAVAETFEESGRRWRPWACNGRSLRVGELILIVDSDTIVPEDCLRDAARELTECPEVAIIQHESDVMQVAHHYFENGITHFTRRINRCISMCCANGEVAPFVGHNAFLRWSALQDAAFVDEADGKKKIWSEANVSEDFDMALRLMLRGYVIRWATYSNRGFKEGVSLTCDDELNRWQKYSYGGFYSDVVYQGCNELIFNPLVQWWRKGPITKQLRTFMWSDAPPHYKIGMMSYMFSYYALSGAFVLSTMNYFLLGWNLPVDGYYEHSFEIWLACTVVFPGAGNLGFTMLEYRLGSRPLLDAVTENLTWIPFFFFFFGGLSIHLSQALLAHLFSYNITWGATKKEVERSNFWQEVPKIFKRFWIALVFCTLMIFVMVILTTDAVPIGWRIFGWDWAVILPLAIVVGCHILYPILLNPWLMIFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFL6</accession>
    <name>A0A2G8SFL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFL6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFL6"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="354"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="561"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="661" mass="69680" checksum="526C0B619227DECF" modified="2018-01-31" version="1">MATAQPISYSSADSQDFVMGSGSFTGQNGSFTASSLTRHFLAGSPLSFRSGSFGSRFYPGVSPGQLLGPLDPNDFKFTKMSSSVESDRGPIVNALAMLERQDELCRDYTCCGLNLTDLHALVEHFEECHVVVLDPFAPQQPLPPTTAPLPAPTGQQMPSYYPDANAVSVPSQQQPQRVQAQQQPQSIAYQGFDPDDMELDVDQSVSSAPSSGAPSPPDTPITTPLSGYPSPTPSVATYSAAPSPHPSQPASPISAFDTTTVLPSRGAHHHSHHHPHHPFRPAGPTATRGVPEDAFNAYAGYADYSSLLPGAAPNASLFMQQGMALAPMNGSGGQNGQNGNGAVCAPTALILSGSAGNTPDSTPASSRVASPIPGGSGPSAYRQNAQASSSGPGSPSGSGSSSSNAQASGSGSAAQTARASTTLSRPASSLLLSKPFKCPKPNCNKSYKQANGLKYHMTHGSCNFAPPKDLEHLQELLASKRSEKAAASGQAGGEGEVTLSDAEMREVEKEAERRLRPYACGVGECQRRYKNMNGLRYHYQHSGDHGAIGLALLASGQHECLQHNKSRHATPSHSNSNSVPSTPQTHSRAASQHSSPSLSHQQPQYVPQQQQQQPQPLPQPPTYQSALANPPAYSYQPQPQHQPGAYVPQHYATQHYMPQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG88</accession>
    <name>A0A2G8SG88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG88"/>
    <dbReference type="OrthoDB" id="5599874at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="342" mass="36588" checksum="2F968548FBAE0325" modified="2018-01-31" version="1">MESTPSKAHAAPHRLPTVVLSPSPTLISFSTGSASQSMLRRRMAAGLCSMTVVLTIESLRGHPLNFIGTVRVKDVRIESPPQISPSTSIQTRHSPISFENLFCLSPITPSDRRRPRNSRSHHLRRTVALPSLLFLLRTSILHPHPPSILIPPATASTSHTLPHTLHLLAAPILPGPPPLPSFRLLRRGPTSCRPPLAFGGTGAGAKRKRESVKFDRSAAQAAGEGSAREAKGKRGAIVTGLLRMHAKALGKGARVGAGKGREGDVCKVPSVPVRRTVSEAGVFGGGAGSGKGKEKKAEAKDGEKAEQKRNREREGVERENKNAVKRAVINALAREGIWKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG95</accession>
    <name>A0A2G8SG95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG95"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013963688" evidence="2">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="240" mass="25366" checksum="2223A1F63717B639" modified="2018-01-31" version="1">MPSFDRLLVFSVLALAASVLSAPVGTDRGHRGVLPASSANNVGGVVSGDIDDRDFDEQNTHHNNEDAGSSIHQRRAATPTTGKTTQKPRPTKMASPKSTKAKTAAKVTPTKPAKSTKVKATAKPTKSIKATTRPTKTTKTSNTASKASNGTAAAKPSACPIEQPAKKHRAFTSRAYDYVAHLFARDSAEFIGWHGTNSVCPAYLWVAIHSADVLTRKPPPYGRPAGTLRSRPKGSAITCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGV6</accession>
    <name>A0A2G8SGV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGV6"/>
    <dbReference type="OrthoDB" id="10661041at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="246" mass="27912" checksum="DFD3F8C6F6AB28C0" modified="2018-01-31" version="1">MSIDLKTKNEEAPVAPTNNKATTHQRTNSLAEQIAQNWRAMPQEEQHRWTAATEAVEADSAFEPLHLHLEPRPLPADRELDIEQFPTEPQFPTDDSTNNTTLWFADNLLFLPVVRPVAGPTMLPPWRRPRAFSGGLKNVSLITFLPLAPDEDEEDEEDEEADRIALKSEKHSQTFDAPTLADRKAGAEAEAEAADERDDSLCQRPSWMWVQCPLEAPIRGAHWELGMHERFRTTGDIPAHLHSWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGY8</accession>
    <name>A0A2G8SGY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_04471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGY8"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="206" mass="22716" checksum="07AE60374DEAE41D" modified="2018-01-31" version="1">MPDGYDYLFKLLLIGDSGVGKSCLLLRFAEDSFTDSYLSTIGVDFKIRTIQLEGKTVKLQIWDTAGQERFRTIAAAYYRGAHGIIMVYDVTDMETFSNVKGWLQEIERYASEDVKKLIIGNKSDLVEKKVVEYSAAKEFADNLSIPFIETSARDSTNVEEAFNLMAKTIKDDVDSQPEEASTGAKASTVTPGRSLNGEDDAGGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH25</accession>
    <name>A0A2G8SH25_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH25"/>
    <dbReference type="STRING" id="1077348.A0A2G8SH25"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="322" mass="36655" checksum="8572BFD043F11A84" modified="2018-01-31" version="1">MERSSSIDSLSDDELYSLVETVSRDRSQQVGYIPSIDGPIPYLVWRIAPDAVAKLSVGPSEAYTMQFVRNNTSIPVPTVRRVLPRPADRRGTEDRYWIVMDYIEGNTLFDVWETFSEERRREIIDALARYVRELQAVRPPHPSIPGPLHPKGTPVKCSGSFFTYDDAGPFRSYQEMASWFDRQRSRIRIYNHHVFGGLMACPKFDASYPLVLCHMDIHPRNVLIDEAGTIWLLDWGYAGMYPVWFEYASIAVSVKADWRLAAVPAWKDLVANASTIAGDYARYYEDYLLVLFNSVGGINFDVQGQALGVVDDYFEKLGITVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH73</accession>
    <name>A0A2G8SH73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH73"/>
    <dbReference type="STRING" id="1077348.A0A2G8SH73"/>
    <dbReference type="OrthoDB" id="2681331at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11788" checksum="6F5E3D0292F41491" modified="2018-01-31" version="1">MDMDMVCPVRVCAAQVLVVLTPSESYLVDILHDRSAESIAASSAFRALVSAFATTGMLPLIDAVRVIVTNALFALVGWLGFAAILLTMRYGARMRAWVDIGFTTEEDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHD6</accession>
    <name>A0A2G8SHD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHD6"/>
    <dbReference type="OrthoDB" id="2750857at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="140" mass="15223" checksum="81E3B146B34BDDAD" modified="2018-01-31" version="1">MPVHCSTNRAATTPSRTSESHSSRLVELRSRISEDLTSNRKARLQWSPKGYARHVIIRGRKILKAADIRARAVWQPQRRPGRPAGDGASALVVDVDLPGALLNNTPPPAAAETIEGAEDSEAVWSSEVEGEASKIDEFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI47</accession>
    <name>A0A2G8SI47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI47"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI47"/>
    <dbReference type="OrthoDB" id="2739517at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="862" mass="97389" checksum="4E729BC2DD237BC6" modified="2018-01-31" version="1">MPPRSVSFAEGTLQHSDSPGRYNRANAPASNTLPNLEENRAELRCNMHGKITLLPVKTFLETFFPSIDIEEPAQPNIFHNMKTPTSERQMYEDLPRMLNAAGITSKFTFVATPYQSDQADPSKQSVDCGMYLNEDTPEPENGAVYARVDWSNLDLSIECKYHPTDQDPLDDAKGDGEPTADKRQEALGQILSYAELVFRYQHRMFHFMILFLGTEARIVRFDRSGIFATHKFSLKEEGHWLVEFLCAYTALSPVERGYDPTVTRVVRGSAAWKAMKQKADTVDDKDQRDYVRELFKSSLDEEWPWWLIEVHPEPSRSSKRQVKRRYLVGKPHFQAPGVAGRGTRGYVALPATAKGQPLKNAKFVYLKDAWRVDHANIDQEGKILKYLNDSEVPYVPTLVSHGDVPSQVTLSQELWSQFHSETACPLKRHTHYRLVVAEVGMPLDAFGDDSCDLVAAVHCCIQAHAAAYKAGIIHRDISSGNLLLYKGDDNEWYGLLNDWELSKKVERGPLEGRQPDRTGTWQFMSAHALNDPLRKMVIQDELESFFHVLLHYAIRYLPHNLKASEVGRFLHDYFDAAGVNSDGIFCCGKTKKAAMRYGVIDVSEYNGDRDSQNTTLRFFWPTRPCHPPQRVETPKSTPPPSFVGSSPPRSPAYKAIFDPYLTPLPSDCTPPPQEDAEMEGEAHPEHPPEHPLNRIIDKLLSWFKAYYSFDVAMLTRTASLTNTAAIGRVPTHRKKFQNIRVNKHKSDEALAARARGAVNSSAQAQETKQQAAQAKRVRDENEALSANLQSHDAILALFDDVLEDVWPVGDRQADKKPAKGYVRPKRQFPQGSTTSRSGSKRRTADEEVEDASEHKPSKRSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIY5</accession>
    <name>A0A2G8SIY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIY5"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="282" mass="30718" checksum="816E6B100CB6250B" modified="2018-01-31" version="1">MHIASDIVVSLYNPAGATPGMLSSGVEVRHGDYNDPASLDAAFAGTDRLLLVSSPSIAHTQRVAHHMAAIDAAKRAAVKRVYYTSLAFASDSRAAVMQAHLDTERYLKGSGIAYTILREGIYSESYPLYFGFWSATEGEDEVLVPHSDGGIAWVCREDLGEGTAKIMVGGGYENETCLLSGSRTVTLGQIAEKVSQLLGRNIKLAVGSEDDYVQRNLGKNGPRGEEEFLRKWATTYKAMERGELEVVDPLLEESVGRSLKPFEHTLKETLSIHGSVMEQYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK96</accession>
    <name>A0A2G8SK96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK96"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK96"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044980">
        <property type="entry name" value="NDUFB2_plant/fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36987">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="69" mass="7831" checksum="2AD84E184D33603C" modified="2018-01-31" version="1">MAGQHSTGFNPHLPGFKHKFLATTLGATMWFFIFYRARKDGAKLLGLKHPWDGHDHDHHGHEAGHADHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLL6</accession>
    <name>A0A2G8SLL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLL6"/>
    <dbReference type="OrthoDB" id="3267785at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="126" mass="13240" checksum="84BDA018F1B2E12C" modified="2018-01-31" version="1">MFSVGVLGLWDAAFNDSSLLKGALGLTVDGNESSWATLSDLMKRQSDTATASSSTSSLVSHKYYLIIIFVGLFLVVLAGICLSAWCCRGVFENPLCCPCYVCACCGGLACLECIGCGLCAEGIEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLV2</accession>
    <name>A0A2G8SLV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLV2"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="115" mass="12559" checksum="D21145CC4AB8E67A" modified="2018-01-31" version="1">MPFRVPSARIAQASPSISLEKGSYRMRAPPTRKPAARLQTSKSHARANGGPVSEFIPASHEKRMALLVVLLACATMASFGVAYYLWTTRPISSILLDDSDIPRLCTLFSRLALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SME3</accession>
    <name>A0A2G8SME3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SME3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="87" mass="9872" checksum="FC50974452F443FB" modified="2018-01-31" version="1">MFSFSYCPRFTDKTSQGALALRDLSLQYSIELSMNGMVDSDHSLTTLPVSVRMQRLRHYSSDFSSGAFHRQDLTAHPDAIFLDGHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNU3</accession>
    <name>A0A2G8SNU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_02119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNU3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNU3"/>
    <dbReference type="OrthoDB" id="5579860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL35393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="442" mass="49235" checksum="042C66A65A16DEB9" modified="2018-01-31" version="1">MRLRYRYGPIGHGSFGRVYMALVTNERALRPVALKKVHITDHAKHPPLLHEAAALLRLQSHRSIPEPYGWGSSQFFEYLSLELLGPDLYSWFILGKKPLTSRNLDAIAWQMLDALEYVHSQGIIHCDVKPSNIMLGRGANKSHVYLSDFGISLSFDPNAPPSERTTLPRGSAYYMSLNNHSRRALSPHDDMESLAYTIIQLRMGRLPWGTFTSHAEVFVSKQRWTGEHWTATTDCPQVYGQFLDSVRDRGQVLDYARWKRELCGDSVPTSLSAEAPYKYDPSDHDTPISRTGYDSELEKPLTASGRELARVPESPEPWPPLSGSSHGFYELSTWSGPVTLEEAATFGPEREVVLRALALIDRPPACGTSEGVSNSREVMKTFDSILGENVGRAVGGDREGDSGDGRDGRGSGESEQADSGNAGSALDESEFRQFYDPEYDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNW2</accession>
    <name>A0A2G8SNW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNW2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNW2"/>
    <dbReference type="OrthoDB" id="3360544at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF97">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE IRON-TYPE_GLYCEROL DEHYDROGENASE GLDA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="188"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="384" mass="40808" checksum="658A3135DC101170" modified="2018-01-31" version="1">MSITSPNLSGFYAYTETLKGVHYGPGSVKTALPKLLASVGGNRAFIITGKTLYTATNVVKTVENVLKEHNAYSATFYEIGQHAPIAGVRNGVKAFKDAGADVIVSVGGGSPVDAAKAILYFIQQETGGRCLPQIAIPTTLSAAEYSIGAGFTNEQGEKSRITSTELAPAGIILDAELTLATPERLWLSTGLRALDHAVENLYRPGPGVPIPLKYLCCVAIADLFTYLPKSKANAQDVEVRQRLQVASWMSVWPIKDERRGPLGLSHALGHKLGATYGIPHGITSCLTLAPVVNLKAEVASQADKEALAAVLFYLRQESTGSVNGDVRKLSSLIQQLVVDLGLKSTLSEYNVPNDDLPKIAQLAVGGDNNDPLVNNVISLLQGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP20</accession>
    <name>A0A2G8SP20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_02228</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP20"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP20"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="12">
        <location>
            <begin position="243"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="598"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL35500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="639" mass="68920" checksum="8F7012EA49612823" modified="2018-01-31" version="1">MHMGEHTRIRLSFVSPPTVSLSSLAAAVVAVTAAAHPPVLSKRVVHEARTFAPAGWSLHRRADPDAVVPLKISLTQSNLHRLDEYLLEVSDPESTSYGKHWTPERVAEIFRPSRESVDTVHNWLTNDCGIHPKKIRLGPNGGALHLDVTIAEAESILESEYYVYRHSEDGEERVAFENAYTLPEYVAKHVDLVTPSLHLPRSGASLARRAGKSSPVFARPSGAPKAAITDAEVPTDADHCDTYVTLECLRKLYNFYYEPVVPQKNTIGVVEVSNEVYQGQDLDLFFDKYSKSSVGDRPELVSITGGHLNPNETNTSFLGESTMDFELVMGLLGPKQNVSLYQIGAAGDTWDEALVAAFDKSYCSQSGVRSGLDCGNKPTSNVISISYHFEPDYPDPSNARILERVCAEYGKLSLTGMTFVVSSGDHGVAYGSQECFVNGTLVTQPDKGGFVGQFPASCPYVTAVGATQLAKNHTIADGEGATSDFPSGGGFSRIFPRPSYQKRAVTRYLNNYVPKSYDADVFNNTGRAYPDVSANGYPTVVALGGKFTRSGGTSAAAPIFASMIAAVNDARISAGKGPVGFINPALYSNLFRSSFNDITEGSNPGCGTDGFPASPGWDPVTGLGTPNFVHILDRFLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPB3</accession>
    <name>A0A2G8SPB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02339</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPB3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPB3"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013936816" description="Transporter" evidence="13">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="311"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL35611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44582" checksum="955629FA9AF352F7" modified="2018-01-31" version="1">MLSTVPVYLALATFASLASAHVAFWHKSMYGFNVTDKTFSYDNRPQVPLYGMTFDQWWLHGHKDYPPHDGDFFNLPAGGKVNSELSCDKGATSWYNSSQGGDVGYGSNSPCPGAPLSAFHTTGQSDVKGCALAIAYQSDVNALQPEDFTIFSVNQTCVWYLNTEFSVPKLPACPEGGCHCAWFWIHSIDSGSEQMYMNAFKCKVTGDVGTQSLGKPALARRCGADPNNGRPNATPGNCTIGAKWPMYWYQKERNNMFEGTYEAPYYNDLYGWHDGAQDDVFENGVISSLAGSVASATSAIGSHVSSILSTAPTAHQSSSSHTSAATPTSEPKPTTTHAPSTSEQAKPTTSATHSSEQPHTSATPLTPHVEPATSATSTAPSTTSTGKCKRKSKQRRAAENAKRLYARHLSGLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPH9</accession>
    <name>A0A2G8SPH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPH9"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="302" mass="33725" checksum="EF9B5EEDDFB656A3" modified="2018-01-31" version="1">MEGYLDFVVPGVDAPCKTWYKVFGDLKASARPLVVLHGGPGIIHDYLLPLTDLTSLYSIPVIFYDQIGSGKSTRLPEKNADAPFWTEELFLAQLKELLEHLGIQNSFDLLGHSWGGMLGARFATSHPAGLKRLVIASAPATMNLWVEAANHLRAQLPPDVQAVLDKHEADGTTEAKEYHDAVAVYYSRHLCRLDPTPKEIVEVFEALQANPGVYMTMLGPSEFNVTGSLKDWSILEDISKINVPTLLLNGVYDEAQDNVIAPFFRSIQKVKWFTFAASSHMAQYEEREKYMQVVGRFLVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPV9</accession>
    <name>A0A2G8SPV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPV9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPV9"/>
    <dbReference type="OrthoDB" id="5585746at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF97">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="430" mass="48174" checksum="79F9DB002459EA7E" modified="2018-01-31" version="1">MSRSLSLRTCWTLPPSRKWPRTSRTCQTSSGPTSPDFNLSDVRSRLDDVRSRISDLDFNRPLNYVPTLSNRLQSLQEHLSSMELASSMYLSSFAPSATLSALLDKVLSSHLVADISSDLQRGEESLEQAALEIARAMKRSLNGSRLIQYVDLPEKWRNNPFVEGGYRFIPLHDWPRLVLSLFALHNETLNIHTHLIPFLLWSFAFFRFTPSYDGSNIQEPEPVKATFTAFALLCLFTSTVWHTMSGCAHPEGMEFCARVDYVGIGWLISASVGTVVYYGFQCRPAERDAFLVLCFLVGLSGSIVPFTNWFNERKYKNARIAFFLSLAFSSIAPLIRLAQLHSTGAMHEFIAPIVPSLASYIVGLVFYATHFPECVLAPRWPGARCWLDWLGGGSHAIWHVFIVLAIRLHREGMEDMKAGIGEACGVAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ54</accession>
    <name>A0A2G8SQ54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ54"/>
    <dbReference type="OrthoDB" id="2747916at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="227" mass="25360" checksum="6E5B20958F47EB77" modified="2018-01-31" version="1">MAHPPGSTILANANNIVILPLYSLTMVYVNITLRFAPWEYDPETDEERKICCMKVDIAGFPAYLESLLPKVPILFEVIGQISPYDCFLTADGYQSPESSGQEDERLATCWIEAPHDYISRIYWMGIDPAIQEITGFIPGDVNTDKLLGEEDREVILQVCYQPPAGQSITSALPFYNSHGQREVLSSMAEVPFGQPMRIAFALESCFRRGEADGQPILIAVLEHMVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ70</accession>
    <name>A0A2G8SQ70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ70"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ70"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43832:SF1">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="23874" checksum="382A033FE3C2477D" modified="2018-01-31" version="1">MPTLTDSILEVGYHLLDKGLVPDVVLRPAIRALCRQRLREIDHGSFEANFAAKMKWIEGVRARSKIADVPEKANEQHYEVTTNFMLSCMGPCAKYSCCLYPTGKETLAEAEVLMLESYCEKAQLKDGLDILDLGCGALFGSLRESSWSYSAAKGWGSLSLYLAQKYPKSRIVGLSNSSTQKLHIDKTAETRGLTNLEVLTLLFITLAPYSLKTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ98</accession>
    <name>A0A2G8SQ98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ98"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="13925" checksum="AD439126D39F793F" modified="2018-01-31" version="1">MLLSRAFVSHRASGVVWQPIVLGAALVISIGIACCVYARRRGRNKGDPPPDGRTVASRAQVRSGSINPSAKETMRPTSDSEFSLSPLPGRRLDHDAERRIPNPVLHPPASGPPPTYKGSQPKGSQPEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQB2</accession>
    <name>A0A2G8SQB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQB2"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="283" mass="31098" checksum="B49FCA924E171801" modified="2018-01-31" version="1">MAHRRTFSARFPDMTPVMLDSPPLTPIPNVGGFPISGSRKPRAYWARTTLLAGFAFVALSLYLLVVSHPALRAPSFLDTARPAAADGARWSSETFRKALKHKKPVAAAADFSARPQIVLNATQELAAVSSFIASLPQNMIPATVDPSLPIDPQLILDFDTRGPHAEEELQAVMQDVWTRNPVMLYCKVHSPVSRELKQVLKNLYLRPASTIVDVDTRPDEHVLTQLLYRLTSASELPILLVGGRIIAEPKEIKWLAETGDLQKAITEAGAVVDGSRKKKPKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQN8</accession>
    <name>A0A2G8SQN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQN8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQN8"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="301"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="86270" checksum="DFDB0DEF67E569CF" modified="2018-01-31" version="1">MPPPPSPSNTSASSRAVSLNGPPSADLPSSMSDLEMNAKAIQDRISGLMSARKTPSSPRPDSRVSTSDSLQLLDLQGQIERFQARLDAAEDENNRLRTRTDGAEREASSRIEALVAERDCHASRVSELETASRTAERSLAERDAQIEALQRAAEQAARDAEKVKLDGEARLRDAQSMLEDKEALVAQLKEAVDAREGEQSENAALLKAKNAEIAMLEARVQKVSGELEEERRELGGHVDELRKAGQETIALYEERLSAADAKRYELEDMVVSLEEQLRTQARPVSPSTVARQATSAVEIDNEMLRDQVQHLQKKIGTLEDTLEDMRTANEHEDAAVRERIKRYKEREEATRKELTEGRQEIERVRKGEEKARMRIEELEEAFRENTIALENAQAEVETLRNEIADLEGLAAAAASNSAGELAPRANAERAKLQEEVAALRQQLAKAQAAAPSAGAGAQALEEELHLLQEDRETLQESLKRTQAELADERAIVEELRVLANERTTELDTLRKKLNRDGSINGHELKAPVSPSSKHDMAAAREEITGLKHIVQELQKENAAHTQRSKVLESENKLLMSETEQLREDLKALEEDVEKSLVREEAMLTGEQPPSPSTPSLDDIQALQRSYKDLKSKYETEGEQLRKKLADVEMKSARQAHDIYREDELEREIERLKEKVSRSQKKSSKTDLPLPEESNGRPPSVASTMSSTIGQSDELVCEICERPGHDIFTCDLLKEDAAPPSAGLMSSSLRADSELICEDCEERGHTAANCPHSLDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR74</accession>
    <name>A0A2G8SR74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01929</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR74"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR74"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL36267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="178" mass="19986" checksum="5B3C11CCED4B661C" modified="2018-01-31" version="1">MHTIYARVNNVSAMLSTCLMVLLGAVSLSSFLLTTTPPPGHLSVTNIKVFPGNARRYANKNQDFTFVNFNLTADLTPLFNWNTKQLFLYVAAEYENKQGTKNDVVIWDRIVRRKEDAQISVAGRNKYVFREVSASFGDVPPAHYTLKYNVMPYVGVLTYGEAARTVNPVPFPESQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRH2</accession>
    <name>A0A2G8SRH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRH2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="118" mass="12619" checksum="485DA21CF7904898" modified="2018-01-31" version="1">MFGTAGHNPPRPYPWPRCGLRTLVAGIGRRAGGAPPCVHTLVQRMAYVLIPSLFSTSFAVYVFRWGVESCRRDGKTLTTPPKLCSCGVGACGGDSSTTLERTELGGLGNRPVGWVVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRX3</accession>
    <name>A0A2G8SRX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_00206</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SRX3"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="76"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1085"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="900"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1309"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1309"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1327"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL36517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1351" mass="153036" checksum="75815C7FD3012CBC" modified="2018-01-31" version="1">MDSFGLNEELEGIQDLDNYTFDNETDVSSLSQSGIVHLLEPAVDALANSPDSITDPTVFDVYRSLLKHAAALQGTHMIKILDSISSAYQAEVEATLRDVDSEDQQTYMAHKTPLEMFAFLLAWFVNAAEKVKARGDDDAPPPTAKPKRGRGGKAAASRSTARKQVSEDWSWSDHIPATLALIAKVLKLKTQKIWQTSGEREFFIGCVLRPVRHIAENEQYMKQQQIRFGVYKAICLAVKHHAHGLPMQISIMQLLQYYEHTSEYMADCLDILAREFDHSQLGDEILREIAGMNFSTQDNKGPRAFSRFLIRFAELAPRQVFKQLTSLQSQLDSEAYPMRLALVEVLGSIIHELAEAPQDESDGQQKAKNLKQINGLYDLLLERMLDVSSYVRVKVLATLSKLCEGVAKFPQQRLAMTRAAVEALEDKTSSVRKAAVSLLVKLIVTHPYSIYGGFLSEEEWKVKYQEVADMLEKMEGDLGKAVEHNDREESQEGEGEEEEDGEGDGEEAEGGQQRKKKRKSKPKGDDSMEVDGEEEDDADEDEEEDEADDDEDVQMRDGSDGESDAPKPRKKKGKKRARKSELDLNALANEAAALGALNENQHLEQKLRKKFCLDALDFIRVVEDGMKTVERLLASNNKLEQLEALEFFRVTYEYKFDAAETGIKKMMHLIWAKDNNSTNEEGKELTGKSVRSRLLECYRSMYFEPGDMEHKKQINQIAKNMIEMTYNATLAELTSLEEMMRQYMEEGSISEEVVAKLWMVYSSERRLPKGQRRGAAIILGMLALAKRQVVADRVETLVKVGLGDRGKNDLTLARYTCVALQRLNGSAKKVKGSLLDKTLRLDMENALFRRLQDAIERPCRSREWFPMAEQAINTVYALGERPDLLCGSLIKDLTRRVFGRKPNRASQQQRDPDAMDQDEDNAGPSTQTQGEEDKDTGDAFELSQLLFVVGHVAIKQIVFLELAERELKRQKHEKEMAENIGGAAPTKSKDQEELDQVAGNAEDEIGERIAAMREDELLHGRQSLLATFGPMLVHIVGSPHQFKNKLLRATATLAFSKFLCVSSSFCDNHHRLLFKVLETSKDAAIRSNIVIALGDIAVSFSRIIDESNDELYKGLRDQDMVVKKNTLMVLTHLILNGMVKVKGQMGEMAKCVEDEDERISNLAKLFFEELSTKDNVIYNNLPDVISHLSIGAHAIDEEKFQATMKFIFKFIEKEKQAENIVEKLCQRFRISEDPRQWRDIAFCLSLLPFKSDRSVRKLVEGLQFYRDKLHEETVFARFQEILVKARQNKSANKPDAELNDFEAVLEENRRQGADDQEFEKRVEKGKAAAKKRAARRTQRKKAAPVRHEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSG0</accession>
    <name>A0A2G8SSG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSG0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSG0"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013627741" description="CMP/dCMP-type deaminase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="26872" checksum="88C76B2C6D6AB925" modified="2018-01-31" version="1">MMHPPVGIIGSIVLLAIPFVVGHNHGPNHLAARHEHGHQYTMHGPVIADPTLSINGIPFSTRAHWMRVANAALAELESPCSFSAFATAIVNHTAPGLGELVCIGVNANSKTGNPTLHGEIAAITNCTAVMTDPDGPFRFTPSKAQAAFKQLSLYTNAESCPMCASAIRWSGFREYIYGTSIDALIEQGWGQIRIPSISVFEQSFDLPTQARLIGGLLTNETDPLFFWQFNPDFPCPEGCARVSGTCKPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSI0</accession>
    <name>A0A2G8SSI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSI0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSI0"/>
    <dbReference type="OrthoDB" id="3263055at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013742028" description="DUF6534 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="166"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="320" mass="35028" checksum="211D882E34DDDB22" modified="2018-01-31" version="1">MGILLISVVLSGARTNATSTSLWGVSCSQVLYYYIRFPNDPLSIKLLVGAVTASDTIHQALITHSIYWYLVTEYGNPRSLALLVKSIVVEVIFQCITGFLVQGYYTICVWRLSKGKLYLVIPVAAMVLTEFGLSLAYSIIALTRLETFSDLVQIKMLSACTNIFAAIPDVAIASILCTILYRSRTGSPKSNILINRLMVFAINTGLLTSVCACISLITFFAFPTTFIYICFYFLIGRLYANSLMAMLNARRSRRDGCNSDDTTVSLREVPTAGSNLTHCNVNAPSSPGGGRIAIRVNTTKEMKHEPMECNTAGTFGPDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSQ9</accession>
    <name>A0A2G8SSQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSQ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSQ9"/>
    <dbReference type="OrthoDB" id="497927at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47098:SF2">
        <property type="entry name" value="PROTEIN MAK32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="73" mass="7770" checksum="0A9AD83B8667687E" modified="2018-01-31" version="1">MPKVPTKELVEEACRRFLDMGVGPDGQGSVVIRCGPMGACIAVKGSAYSWIDPYWTSENSGKVVDVTGNHSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSS3</accession>
    <name>A0A2G8SSS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSS3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSS3"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9712" checksum="6DC7F4FA263CD098" modified="2018-01-31" version="1">MSSSCSHLLDALKDCLLHSDCVLKQGHLPSDCLKNHTDELPEACQSLRKATFECKRGMLDMRKRFRGNNIDLPPPPPKAPEPTTPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST61</accession>
    <name>A0A2G8ST61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00612</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST61"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST61"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34473" checksum="8F1CF942CDFBB096" modified="2018-01-31" version="1">MILTASRVSNLTALRSVRCAYAGRRFLQTQIPPASASSAEAYLEPNHDYPGIVSLLLNRPRSKNAISLRLLKELQECLDIVQFDKSTRVLIVRSSTIGAFCAGADLVERATMSKAQVDKFLIDLRRALGTLENLPVPTIAAIDGPALGGGLEMGLACDLRVAGEHSEVPFRVAEEAKAGVREGHAVTKIGLPETKLGIIPGAGGTQRLTRLLGMAKAKDLIFTARVMTAQKALELGVVDYVSEPQTTGYDRALQLAGEISTSAPLALRAAKQAISRVPDVGFESGLDFERASYEPLLHSQDRLEALKAFKEKRPPVFKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STB4</accession>
    <name>A0A2G8STB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_00709</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STB4"/>
    <dbReference type="STRING" id="1077348.A0A2G8STB4"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="289"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL37017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="716" mass="78107" checksum="86D677DC36878BFD" modified="2018-01-31" version="1">MPSWGPHAMIPPIVASISTPTSTSVSDDDTVVITIGRSGGHPEYIWYAILCLLALAMATNVSYSGWAAYSRSHARRESESTTVATRQSSGRLSYCRGPQAILAALRIFSFRWRIPYIDMMLVEVVFTVLWMGGCLAYIFAPTDNVHHLLNLQPRYWGSSAARVAAIQLPLVVILSMKNNPITSFTGIGHEKLNLLHRVISRCIVFFIWLHFAGMFYYYRSFPKLLNEMWRILGFVGAVALTVTTVIGIKTVRRRFSVFFYLSHVVLVLLFLITTQLHVTPSGHAVYVWSVWILWGLDRVVRLVRCLILNFILRPKCRNAFVEVIGLGGLRVTMKRRVPGGWRAGQHVFVTFPTVGLHSRALTIANAYEQGQDGDGADMAFVVRTMDAQTRTLIDRALATGSCELPAIVEGPYGCPDDIRPYSTCVFIAGGTGVNYTLARMQQLFKDINAADARATRVVFLWIIRTEGEYRWLTADLSRVLSTAPPNLSLAVDVHVTGGRALIESQILQTLRQGSDTIGDGDDGQWLSHSTTLSLVDGRHRGCCSCSNSSDAEFTYTKSAGFPDSPTLPRDPGSPSLSRTASGSTSTSSSSSTPCADQGLLTVPTAAYSCQSCSCCSCPLQSPSMLHSPMSLSDHTASDTPTTIACQAVRRMYGRPDVRKILEEGIATAQGAVAVDVAGPDELVNAVRSALCAPFAGPVAVLKGAPTVMLSIKQFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU52</accession>
    <name>A0A2G8SU52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU52"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU52"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="11655" checksum="654A5091D191345C" modified="2018-01-31" version="1">MSFSVGSDLEGSRVQPLLAHLRGYPISACGLTDFAGKDWDLNLVRDAQAHFERSRAIDPSNVVAEAFLSQLHGTTQAPRDRQSPDSDDEKMNVDEPTQARKRTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU80</accession>
    <name>A0A2G8SU80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01013</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU80"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU80"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000259">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="193"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL37320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="620" mass="67997" checksum="19401BE62DC1012A" modified="2018-01-31" version="1">MSDSPPLLNPFDDTNGRNSKASVSPSPSVKGSTYRLVSSDRSSGPFPSIARRLTAYGSNPSLSAASDSPYLGASRPLSLGDQYTLPPDPQTWGTRLLPEDKEEDDDLHGPDPDVRGERIWADNGGDVFSSRGVINLGALVLLIVGILVLFVGFPVITAVTQKQLTNLGAFNLGGINASGQVPDIPGHRGLIDVDTPESAYQKTSWRTGEQLELVFSDEFNVEGRTFYPGDDPYWEAVDLHYWATNNLEWYDPEAIATQGGDLVITLSKKETHDLHYQGGMMSTWNKFCFTGGYIEANVSLPGVSNILGLWPAIWTMGNLGRAGYGATLEGTWPYTYDTCDIGTVKNQTIDNQPAAATVNGDTGHNGILSFLPGQRLSRCTCDGEAHPGPKHSDGTFVGRAAPEIDMFEAQIDQNTLIPGVSQSAQWAPFNHAYIWQNTSANEIITDPTISNQNTFKGSVTQQATSVVTDTDPNCYEYETGCFSIYGFEYQPGFEDGYITWISNNKISWTLNGPGLGPDDLVEIQERPVPGEPMYIITNLGMSYNFGPVDLDHLPFPVHLRIDYIRVYQPSNAINIGCDPKDYPTASYIEQFAEAYSNPNLTTWVDDYHQAWPKNSFLNQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVC1</accession>
    <name>A0A2G8SVC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terpene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVC1"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="183" mass="20338" checksum="CFE176B34E104FF1" modified="2018-01-31" version="1">MFPKEAFHHPVIEELENAATHLIIIDNKTGDKPASRTSFLTTRDKPQATNIAISSLSPCIKYLLPDGPRLGRGLDNRITQGRPTPRFLENLPLVPSFGPAVDGAVHKYIAQLADIRWSFEWGRYIGDKGAQVEKTRTPPVFPKRARKTELRRELVEIPLVEELEGTFSGANGDVLVDGMARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMA0</accession>
    <name>A0A2G8RMA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_15330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMA0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMA0"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="28"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="472"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="616"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="617"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="671"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="773"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL22639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="862" mass="94466" checksum="27EDA95418D42A8D" modified="2018-01-31" version="1">MRFDPFQVSIPHIAYAALGGFVVLFGMFSLFIREKLYVGEAIWAFLFGVVIGPYGANIFDPRGWGGGERETINTITLEVTRVILAIGVFAIGVELPKAYMQRHWKSLLFLLGPVMTWGWFISGALIYALIPSLNFLSSLAVAACLTPTDPILAAAVVGGKYADKHVPAHLRHLLAAESGCNDGAAFPFLFLALYLIVDPSTGRAVSDWILLLWLYQVVLGIVFGALLGFGFRHLMRFCESKELIDRQSYVAQYVSLAMLTIGATTLLGSDDLLAAFSCGAAFAWDGFFNKQTEQSVFSSVIDLLFNIAAFVFVGAWMPFNNFTDASLGLSLWRLFVVGILVLILRRLPVIIALYKFIPDIKTFREAVFSGHFGPMGIGAVFISTLAAEQLPTPENPPVGQQQLLAASIQPIVAFMVLCSIAVHGLSIPFFTFGRRVHSVSRTWSRHDTMGSTRRRPLLPEWATQIRHVQPGEDIVINRDQRTLTMTPVDGSSTQEDKPVDEEPQTPHEKVTPPGSEEPPDGSAVVSEWREGPHRVIERREGLGAEVEVEVQRNAYGPSETQTQTFRVAEAVSRHVVEDIRSKLRLAPHELAHMFHAAEEGVKHEVKDIEEWTRTVLHASSPQISPTTSQRDGVGGGQSRGASDGSPEDEGWVSDQSAGEPSGSEAHDKEKSRKSKLPKTKAPKSKSKRTFMRRGILGHRPHTLQRSQSEDFNQRRHAQFATPDDERTPSGAQTPSEETRGRSSAMRSPRLPRTPVSGATTPVGPNPHLRLAHRRIDSIRSELPSREMSPARSVRFVDDGRGGASTPRIVSPTSPTAANGDGDGEKAEDDDDSPKSTVRFSLPGPEVKQTPLRAAGNGNGEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMA3</accession>
    <name>A0A2G8RMA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMA3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMA3"/>
    <dbReference type="OrthoDB" id="2564984at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019317">
        <property type="entry name" value="BRI3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10164">
        <property type="entry name" value="BRI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="171" mass="18394" checksum="1CC1BE49121BF10E" modified="2018-01-31" version="1">MSNLATSMMNEKAQPQAPAPAYSGPPPPNGANPAQPQSPYVPPIQTQGIPPQQYPAQQPPQGQYYPQQYPAGQYPEMQPQFYPTAGVYAQGSIGPQSGFQTAPAQTVYVMGPGAQYQQQLYAMCANGNHDVMTKYGMVGILTAIFCFPIGLLALLVDKERRCVRCGALVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMY8</accession>
    <name>A0A2G8RMY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMY8"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="542" mass="58955" checksum="5122F80363BABE3E" modified="2018-01-31" version="1">MWFPGATASRSHNGVVADFALYADPVINTIRGRASLSFTHTGSGNLKYNLDFDLVPRQYNSSASLIPCLTKAGLNPVTPSSPSYQNDTLPLNLRLIYQPAALVYPNTTEDVSKAVRCGVANDVKVTARSGGHSYASFSTGGEDGHLIISLDNLNNMTLSGDYVTVGTGSKLGPLYWYLWENGQRAAAFGTCPSVGVAGHLHGGFGFSSLRWGLFLDQVVEMEVALRGAPPSFGIITKLKVLTHPAPTHATTFAYTYTWSTPEIASSAFQIFQNFTVETDLPSTLGLQVRYTDASPVPTFSLNGAYYGDDGIAGLNKTIQPLWDSLAALNDSKPSVDILEDLNWIQHVVYEAALNATLDPEATLTETAEFHAPFYSNSLFYPADKLLTETSTLSFTQYTYNGTSSDVSWYVLWDIFGGKRSAISAVPQDATAYNARDMFMNLQASDPASSSHRSGAHEGILGYSPTLPYPSDGVPFVTGILKSVTDLMPDGRFMGYPNYVDSQLGRNEAHAWYYPTHIEKLQQIMKKVNPGAVFDYPQGFYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN21</accession>
    <name>A0A2G8RN21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15608</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN21"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN21"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="745" mass="82767" checksum="2D3F6F599836FB94" modified="2018-01-31" version="1">MPSARTKKESISPTPPSDDPSPKDPSESSKIKRNPSSVSVLPRTPPHLRQSAASVWLRHVVSLSPSSEPPMLTDLALLFSRRQSQSCDACRARKVRCARDNPDDPKGSCKHCITLGIPCTYDYQPKKRGPPNLYLRRLQEAAAAAAAAHQENQNGSEIPRSPASTSQSAASPTQTALTASVQLPFLDTSLGSVQGLSALPPSRYPIAADGFHSQFPPLTMTVPSSFGNSRLPEHMAMSISSRSSPRQDEPPQCGSPSDQFSTYPLHNWSYKQYQALSVLPPSVIPPLSYHYRPHRLEDVAPRDTILLIIALFFDFVYPLTPCVHKPSFMADLHARREERDPLFFALVMATVASTLVQVPRSYLPMERHAVRKLAQTCHEASRHISVASYDPPTSMHVVIRYFDSCYHFCEGHDATQHAAFGEAAHIAVTLRMHEESSYEGLDYIECEVRRRTFWLLFGADKSMSILLGRPICLRDEDTTCNFPRELDDEYITPSAYLPQPHGKTAIVSGLNYISRIFALLGEILVRIRVDKRSPPQGQFLTARLEEVQALHSRIVSALGHAPDPLRLKFAHSQSHLPPEFGGAGFRQAAFTEVKDFFDNPNASRANALNPFLVMQANLYVTQQLVRFVIEQYRDELVTSLQGSVDEHRAAEDREMVASDLLNILHSIPIQSIATNGPSLVHKVRFVASTLLDAVRKAETAPASAARAHAYLWDFLSILSEIERNYLLDDDRDGVSNDAGMPLMVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNU7</accession>
    <name>A0A2G8RNU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNU7"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="238" mass="24662" checksum="98BCDF42955E67BF" modified="2018-01-31" version="1">MSTSQTVWFITGTSRGIGLELTKQLLQSPSNVVLATCRNPSKADALQALTASSGGRLHVLPLDVSDADSITSAAQAAEKIVGDKGIDYLINNAGINPGGYDSPFEFDVARFTEAFQTNLVGPALVSKALLPLVEKSVRKTIVNVSSTVGSVSSVWAAQPLSYAIVKAGLNMLTAKQAKARPDLTVISMCPGHLQTELGGASAPTPASVGVGGVLKVLAGLTPKDTGRFINSKGDTVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP47</accession>
    <name>A0A2G8RP47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP47"/>
    <dbReference type="OrthoDB" id="2758237at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58687" checksum="1FA39AF289402655" modified="2018-01-31" version="1">MIKPTSHLLDSTRSPPPGIASQPKSGGGKEPAVTGGGVLQLLIPSWHWKTSALIPTGVEDKDEELMMTSAGQSESAEWSRTAVQRPVPSLPEDIIAQVCDAIFATPLYEYDLSRTLPGLPSSYSNDLDFLQGIPLVSKIWWKPATRCLYEHIIIRQVGQIPLLVRTLTSKDAGIDFGTLVRRITLYECVVYPDSDGLDEDVRTIFERCVVIEELSFQRHPDCEDVIEEGDRVVVSEYGANPVWIFPQIIFPTMAARSPTMLCKLDLVSLNCRRWKEKAITALYNLLLASPRITALTIQNVEIPIGLVPPVLEYLKELTLLLQHSTSPSPPFPHDVWTWGLPNLRSLTLLNGFKIPTTILEKLGRTLTYLYLCYPIVCEDLQPALLSRLCPVLEHLVLYLHPFTLERVSATFRSASESGAPFRRLHYLDMWLTGDAYRRYRTVWGASDAAAFVASARSTFAPALVGVRALPALSLSSLPALADLPNICHPSALERTDDTRVVCVYDIPMLQTTWCVRPAEDWWLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPG8</accession>
    <name>A0A2G8RPG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_14721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPG8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPG8"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL23410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="448" mass="48865" checksum="96A17F6F820E23BB" modified="2018-01-31" version="1">MLDEKAVSATIEESSTHDDPLTERSPLEEERRLVRRLDMRLMPVLCALYLFAYLDRINLGNARLQGLPEDVLHGDPTGVLFDWVNSAFYFSYATVFNFAGLLTVRVCLGVFEAALSPGVALYLSLFYTRDEIGLRIATYNGVAAVAGAFGGLLAFGIQNAHAGIPSWKLLFIIEGVPSVLLGFVAFAFLPNRPEETTMFNERERKIALERANRRTTADVGRVLQRIAAFMDWKVYAAGVMYFASNCAFGSISAFLPTIITTFGFSNAIAQLLTVPPYAVAAIVLGLFQYSSDRLRDRGSFAIASSIVGAVGYALLLAVPSNIHVRYFATFCVTSGTYGMNGAIATWLTDNLGSETKKATGLPLFQAIGQSGAVLGSHLYPLREGPRYRKGFAVNCGLDLLAALVAVTLTIVYRGENRRRDVQYGKPLPNAPVDTTELADKAPAFRYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPU3</accession>
    <name>A0A2G8RPU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPU3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPU3"/>
    <dbReference type="OrthoDB" id="3268677at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="574" mass="63967" checksum="BED3859C2A9A75E6" modified="2018-01-31" version="1">MIPASAQVPAEVGDYTVANPALEVEAGVSHTSDHAEWGRSTTHKDDPSVEHTMHEEEELDIPLPDVPSPETYLGFPDTFSCVPLDCEGSPHPSIPPSPSAISLASTAPQSSCPSSPPGSPMLVSSGPASPKHLASSPSSCFESLAIPDDLSMLDDVMSFTESPAPDKPPSPKASSLPKLATIFTLAGMKAATSTLKRKSEEAAAAKSGKRHKVASEGGQAGQSRSAVASREAREKAAKGEFVWSPKKLTNWQFKIWELDEDAVLGEDNLHVRCSCCGKWLKIKEAYDATRYKDHYKDCKKKHKGGLPTLKQMAGWFGWTFRRPKTAHQSQYIVQEESEPTTDLQHPCRGVDARDDERIGTYLRRTGAVGGGGRSPVVIAKERLKKTFGDLTRQQKMTILDVQISEHKWRNDFRRTRVYATNCFNYVKTPEKSCERCCALLQLGRFRRAIRKPIPKDENYIFVNHLYRDPHLGELYAKTLGLRGLLDPDAKGHKSPFVRYTLGVLENRYTGGELLAGLLESVMIQEDKQRRGVGMQNFRWPVEYDRFMHLLAIESPKTFRLVKQYLPARTERSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ71</accession>
    <name>A0A2G8RQ71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ71"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ71"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22427:SF7">
        <property type="entry name" value="GH15728P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="3">
        <location>
            <begin position="800"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="489"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="928" mass="100522" checksum="0E2F1C4A16FE1018" modified="2018-01-31" version="1">MWRSRLYSDVRISLTGTFSSTNHESSTAIFSSHRFILVSRSPYFNAQLLQWNTKPSPGEPLTLNLPSPPFTPASLHFTLGFIYTGTLIFSHRTYDLDTAFHIMRSATYLDLDTLYDEIQARIVQEMMHGLFHAFLEFSEYEAITGGKWGTGGCRCRQCARRAPRVLEFSVLDDVKNSHLERGARRALVGLFGEGWCTSEFAALPQKTRDALLKGLGKRTTPMNVFPLLAASNAALKKLDTIIDTWGESVREMVNSARKTIDDVVCSQAAECFEQTEWIEIMEADGARFDDAEKVEMLLDSLRRGLNEKNAPMAYQVLVDSVLLRPHPSDPEAALLSSTSRVRVQAEQARMDIVRYIRRRWLTIKQDDGFAGLEGWAAKEIASELDLKNEDELLMPATPSSTSRGGRLTVRNGPIPKGDDSETISLHSTRSLAKSVMGREAIKSSAASARSVARSTHSTASRVTTTTISRRIPHSPGSLRPDSKLTPPNSAASLGRASLAGSERAKSPLSPSPSPIPRNSVTTASVRKSTASSIHSTTTADRVPRPKSVAASVRSTRSTTSTIRKGAAGPSTPRAVSGSSRVSSTTTASENSTAFETARSELTPSSVGRTRKTSASSAVSTSSVHTTGASTPRLPKRPPSVASRTTPSIRGKQTDSPKVGPMAKRTASTASVRSTISTRSTATRKSNVRSVSGAPLPFSKSSSPASKANGKALPPPEDENHIIKTANSTSPAVAHEKQASLVSASSSSTVRESLKRKGSADTIREATPAAKQPRGATLEIGIPCIISSKKARFRAYARYIGEVEGELGPWVGVEVPMNDAWPGDKLDGRQWHDGTWGGVRYFDIGAASEWDFGQDTTARRRRNEWLNSLGKDGMKGSLKREGDQLSIDRAKRLRSVSPAVSDMSSSESRGLFVRPQQVLYVVDAVGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQA6</accession>
    <name>A0A2G8RQA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_13438</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQA6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQA6"/>
    <dbReference type="OrthoDB" id="5599235at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="208"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL23689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="299" mass="33763" checksum="7439199964BAFC47" modified="2018-01-31" version="1">MDSFDLSNVDIPASGSRLLSEPTPDISSSSSRTGHGGDDLSLSELSLGDRPQSKSAHRRPFSLLAQPQSPDESAVAHEDAEQGEGGLDETMTQEEMEKARKAAAKTREEKLQHDLFVLKKLNAAFDVYKDALRETKSSTDRVAERLGHTNALLDKYVRILSKSEKITKLILDERWQGAEADEEQLLQEEEEARERARREEEERRLAAQREHERLEQEQREREERETRERLERERAEASRTASRSSGVRGVRGTRASMRGARGATPLVLAKSNMLGGGFSDGHKRFMADEWGQERIVLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQE0</accession>
    <name>A0A2G8RQE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_13460</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQE0"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001389">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="397"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="595"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="886"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL23711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122980" checksum="578B3C888E30DEF7" modified="2018-01-31" version="1">MSRPRNNLDELQRKHPLPVVSSPTKLTTPQTGGSKVKFKPAKSIPTSTPTTATVKRLGSWSTPGFGKPKPPPLKYPSAADNSVSYIDVSSTESIAANASTSSIPSKRLSSGSPEDLFPAISPKRPKTDHVLDKENVPYGDPKGKGKARARDPPRTQLPKSIPSLQAAFEALAPDANLREKSEQELLGVCDTAEDLRRACDKLIGAARSAQEPKDLELLTAISDFLERRAAAGRAELKAVQRGERLPVSVARRAPSVESNLRTGSSTTLADGESYHPDPFEPAPLDIPRTSTPVNHAPAPVSSSTVDAMDADDDYWGVFPSDPIDPLGGPDPGPVATPATPPATQPLAPLLIRDLAPAAPPVVEPTDYTGRPYYRQVFDVLKNTFGLPSFRPKQLDAVCAAMDGRDVFVLFPTGSGKSLTFQLPAICQKGVTVVVSPLVSLMGDQVQALKKLGVNVAQLGGNLSEPEKSQVKAQLWSREKPKLLYVTPEQLQMSNYMQSTLQWLYEHGQLMRFVIDEAHCISDWGRRFRDSYTQLTELRKNYPEVPISALTATANAEVEHDIISRLNIQNCVRLKLSFNRANLDYEVRPKKGHKGCVDEIAAVIQTNYPTDTGIIYCHSRDRCEEVAKELRERFGLQARHYHAALDPRDKLRVQQEWNRGDVLIIVATVAFGMGIDKADVRYVIHYTLPATLANYYQETGRAGRDGNLAHCILFYHWGDATSRIEMIRREDKPDEEKRWVEEDFWNVVRYCSNDVHCRRFQVLDFFGEKFDPAECHDLCNNCRDKTPTVSEDHTEDAIKTIALFEKLSQTGNMVSRRQMATAMRGGKLKAMVDKGFTGVEGYGSLKHLDVQVAERLVDEMFYRGVLTTLSHNAGKLKRGQIQVVLERRDNGKASGSKAPRGKARSKVAANDPVTADSAVASITDSSIAGPPTAGPSRSKKTKTPAAEPEPMLSLFRDDPEDPEWQEDDIEVISSPPPPRRMGTRAVPSVSQPLHMGLDSDVEEVDSPVRQPHRTVTVIRQEDLVNVSTGGGNSEIMEICKEDLLSLRDKIKLENPTLAELLTKDVVHILAVVLPTSRQALAEELEEHDISLEQLGKWENHILTICMNYNFTLTQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQE1</accession>
    <name>A0A2G8RQE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13473</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQE1"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040661">
        <property type="entry name" value="LZ3wCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18517">
        <property type="entry name" value="LZ3wCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="2"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine zipper with capping helix" evidence="8">
        <location>
            <begin position="112"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL23723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="171" mass="19071" checksum="D0EE2EFE05213F53" modified="2018-01-31" version="1">MKGIVSQSVKEVLQSLVDDGLVQADKIGSSNFFWSFPSQRGAIMQNRLATVKAQQEFLRAQVSDLQAAVEMERQARPESNKRGEALEKLATLKAEYAKVETELAAYGACDPVKIEEKRRAIVLAKEAAARWTGDVDNYLMLLSHFTRQNGIDAADVRTYLGVEEEYEDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRK9</accession>
    <name>A0A2G8RRK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_13908</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRK9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRK9"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="346"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL24155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="876" mass="94085" checksum="EB97CA8AF5CEC46D" modified="2018-01-31" version="1">MRRCLRIARLGVRSSSTATATQTKPNWQYDVQPSPSPGVPRSRSWGRPPELARPAESGPSGEQPPFVIPQKRTWERPQPPQQAGTSSTKDLPPHLGKSGRKDLSETLRARTTRDRQRDGRSWSQGQTSSRKSRGESSSLSGLGDILRSDRIDKASTAREEAVDSVRSSKAESEAQVSKSSGQGDKGFASQTWTFGLDADDGQDFRSRQKRVQFKERGSLMSRLGQDAEIPSYSKKSRTSSGQAATKEKTKAPKAPKAVKQVNVDVFIPSVVTVGNLARLLNISLDTFRRRMIRVGMESEASHDHMLTSDFASLLALEFNRNPVINDEAAFDIYTPAVHPQPETLPERPPVVTIMGHVDHGKTTLLDTLRSTSVAKGEAGGITQHIGAFSVPVPASGNSAGPTRTITFLDTPGHAAFSAMRARGASVTDVVVLVVAADDGIMPQTREVLDLVKNSKVGLVVAINKVDKPGVDITKVEHALLAEGVQLETFGGDIPSVPVSGLTGEGLGNLVETISALAEMQDLRAEREGMIQGYVLESKVTKGLGPTGTVLVLRGNLKPGQHMICGTTSAKVRLLTDSNGKAAKAAYPGMAVTVSGWKELPNAGDEVLTGSEADIKKALANRARKAGMEATLVDLEAINEQRRTEREKREAEEAAEDKEKTLAPVQPEGPKELRLVIKGDVSGSVEAVVNALEVIGNDVARTKIIATGVGDVTESDVMRAKAAEGVVVAFSVKVPRAVENEAASQHVPIVSSSIIYKLMDTVTQKVAELLPPIIETRVTGEATVLQLFDIGLKGKKTTQVGGCRVSNGVVEKSKLARVMRDGKSIYEGRLDTLKQHKKDMLEVARGTECGMNLAGFNDLRVGDVIEMYEEVTLPGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT31</accession>
    <name>A0A2G8RT31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_12556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT31"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT31"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="3"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="417"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="915" mass="100845" checksum="D73D1C38AF45D138" modified="2018-01-31" version="1">MRVLIQSQRFTVFSIIDNLVAHQREALKGMGDEFIRGYVNLAEGEKDPRNLMLTFAIDRVLLIEFEVDKFIEDFFNITFCYFPITFRPPPNDPYGITSEDLKATLRSCLHASPAFGKLAVPLFLEKLNAGSPLTKKDTLDTLDVCLPVYGPAVAREFARKLWNALKLEIFQPTDSVTEEKSLKTFQVLIQTIYSTAKEEQNDDGAIEGLAKDACDECMEILGEPEKSQAKHAIKVLCAFMSTTPSVARFTLTRAVPHFVRLFLNPDELPNRAPTLRLLADLIEAARKSTSEDPEVLPDEGNVPLSLYKDEVLGILTVGLKTPASAYPAIDALKSMVLTGGLLTDEELGFVVHNVDEVLQKDDEESDLSDVCLDLLSTISSFAPSHVTGNTLPLLFSTLSDTAPPREAEAERVKYWRTLASLKKLCMQPDLFETLVVRFLTKLDLLCVPTASIPVTTEEDLEPAAAYAHSILRTLADVLSMKIHQGHTDVVKYIDRLIPRLYNLFIYSALVSQERPMAATEPRLLVVAAQIVTLVSQSLSVSRQETFVKAVYAAYFEGDVSGLVDGVQKIPTDKKFNPFEPSASTAQKNLLVLFSAAVVALHKDVALPVPDEAAFLDHLLQWISAYAENALQREALNHLVAAVVNRHADKLDAFLSSSVDAFWSSQIADAAQSTEARRHAIGTFTWLTKALLVRGHASAMKNVDRLIELFDDESVSWDAARAVGRIPGADKILTKGHHAIIKILYAQKYTNSVLPRIVEGAKVSQSSRQNAYLVALAALIKSVPKSTYAHQMPSLMPLLLRGLDLPDNEIRAGVIDTLQAAATSGDKENDAVSEHATSLVSTMLKNSLVSQMPSVKVRVAALRYLATLPSVVRYDILHPQKATVIRELAKALDDPKRVVRSEAVEARTNWLVATPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTJ6</accession>
    <name>A0A2G8RTJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTJ6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="13998" checksum="1292A4D0A9321BCF" modified="2018-01-31" version="1">MNRKMNIPRTIMRQEPLAAVPVLARAVEPDALDGDLEPHVAIDLHVVREPPYPVLPAGELPEFPRFVLPVVQRGAQAWVCKIKKHDVTEVPRLERALDHELELQREVEKCGRHLTRAVKRVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTU2</accession>
    <name>A0A2G8RTU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">MGS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_12806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Also catalyzes the cyclization of FAICAR to IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PurH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTU2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTU2"/>
    <dbReference type="OrthoDB" id="6017153at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01421">
        <property type="entry name" value="IMPCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.20:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000003">
        <property type="entry name" value="Bifunctional purine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.440:FF:000001">
        <property type="entry name" value="Bifunctional purine biosynthesis protein PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024050">
        <property type="entry name" value="AICAR_Tfase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005492">
        <property type="entry name" value="PRK07106.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692:SF0">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="13">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL24919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="600" mass="64195" checksum="9C59312720637013" modified="2018-01-31" version="1">MSPPIALLSVYDKTNLLDLANGLHGAGVRLLGSGGTAKKIREAGIPIEDVADITKAPEMLGGRVKTLHPAVHGGILARSIPSDEADLKAQQISPISIVVCNLYPFTDTIAKPGCSLADAVEEIDIGGVTLLRAAAKNHERLSILSDPSDYAEFLAAWKAGNGDVGQATRSKLALKAFEQTAAYDEAISGYFREQYASSDLPAEKLAGSVQRMALRYGANPHQKPAQAFVTSGALPFKALCGSPGYINLLDALNSYALVKELSEALNLPAAASFKHVSPAGAAVGVELNEVEKKVYGVDDLKEPLTSLACAYARARGADRMSSFGDFIALSAPCDLATARIISREVSDGIIAPGYSSEALEVLVKKKGGKYCVLQIDPAYTPSDVESRQVYGVSLQQRRNDAKIDANLFTNIVTKNKELTNQALTDLIVATLALKYTQSNSVAYAYHGALVGIGAGQQSRIHCTRLAGTKADLWWLRHHARVLALPFKKGVKRPEKANAIDLFVAGEPLEGAEKTQWEALFETVPSPLTEEERRAHAAQLDGVACSSDAFFPFPDNVHRARRSGVRYLAAPSGSVMDAECVKAADEHGIVFAHTSLRLFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU08</accession>
    <name>A0A2G8RU08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12851</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU08"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU08"/>
    <dbReference type="OrthoDB" id="250836at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="491" mass="53811" checksum="9DA48BF87554998A" modified="2018-01-31" version="1">MSNPLNATPNPSPGRSRPVTSKARGICAYYNTKYGCYAGDRCKFLHGQDERLTSYDRSKVCRFYAAGYCIHGDKCWFVHADPGSSSSKPPADFEEENLCAICYDKPTTYGLLGDWLQSCLLSIEGDSRKAEAIEKYKGSMARVKCRHFEQSPPGKRFCPFGNECFFKHENVDGTSYLFQHGADFYMGRRGSRRNESDFEWEHPNDNLEQMLDGIRLVAHMSTRDIQQAILSSVAAFFGRDPMYRLDEGPAREDVIPLVADESEGEEQPPSLQPPQSEEAMANPLSGGLVGPHQAFAGSSTTPRSPVSTATSTLDPDSPIFEPLHLDNLRPLPSGPEEDAAHLERLFRGLEDQQRAIQENVSSSSEPSFPSIVLNTPPSGSTGDEAVQDADPPFMTDGRGRVVWSRRSSSLSRVRATSSSATILPHSKSTIDLTSTQEDSDGGLQQTSPGRGPSSIPRQLVRRRSVPLVGSSAGAEFVTDGRGRVVFASSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU72</accession>
    <name>A0A2G8RU72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_12938</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RU72"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000005">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000082">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015348">
        <property type="entry name" value="Clathrin_H-chain_linker_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09268">
        <property type="entry name" value="Clathrin-link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clathrin heavy chain linker core motif" evidence="9">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="543"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="692"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="839"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="985"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1134"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1280"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1431"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1626"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1626"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL25049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1689" mass="191302" checksum="EC2997057FD47840" modified="2018-01-31" version="1">MDISKPIAFCEHLQLSAIGIQPASISFQTLTLESDHFICVREKVNEANQVVIVDLADANNVLRRPITADSAIMHPHQKILALKSGRTLQVFNMETKQKIKSHVNAEDIVFWKWINDSTLGMVTETAVYHWTISDATSPPQKIFDRHPTLVGAQIINYRTTSDEKWLVLVGISGNTTNPAAFKVKGNIQLYSRERGVSQPIEGHAAAFAELKVDGCTKPTKLFTFCARTAQGAKLHIVEIDHQAPDPPFAKKNVDVYFPPEATNDFPVAMQVSKKHGIVYLVTKYGFIHLYDLESGACIYMNRISGETIFVTAEHEVSNGIIGVNKKGQVLSVSVDEQTVIPYILTTLNNTELAFKLASRANLPGADDLYIKQYQQLFQSGQYSEAAKIAANSPRGILRTAQVIEAFKAAPSPPGGLSPILQYFGILLEKGELNELESLELARPVLQQGRKQLLEKWLKENKLTCSEQLGDVVRPFDMTLALSVYLRANIPNKVIACFAETGQTEKIVLYAKKTGYTPDYVGLLQSIMRVNPEKGAEFATQLVKDEAGPLVDVERVVDIFMSQNMIQPATSFLLEALKDNKPEQAHLQTRLLEMNLLHAPQVADAILVNQILTHFDHPRVANLCEKAGLMQRALELYEDIADIKRVIVHATAFPTDWLVDYFSRLTTEQSFACMQEMLKVNIRQNLQIVVQIATKYSDILGPVKLIEMFESFKTFEGLYYYLGSIVNLSTDPEVHFKYIQAATRTGQIREVERICRESNHYNPEKVKNFLKEAKLSDQLPLIIVCDRFDFVHDLVLYLYQRGLTNFIEVYVTRVNSVRTPQVIGGLLDVDCDEVTIKSLLTSVPGNFPIDELVHEVETRNRLKLILPWLEARVQAGSQDPPVYNALAKIYIDSNSNPEQFLKENNLYEPLVVGKFCEARDPYLAYIAYAKGFCDDELIHITNENAMFKQQARYLVRRRQPDLWSQVLRGDNMYRRQLIDQIVATALPESTDPDDVSITVKAFLTADLPLELIELLEKIIIEPSPFSDNRNLQNLLMLTAIRADKGKVIGYIDKLQNYDTAEIPRIAIEHGLYEEAFLIYKKYEQHAEAINVLVEHVVSLDRGVDYANKVNQPAVWSRLAKAQLDGLRIKDAIDSYIKAEDPSNFAEVIEIAGRAGKSDDLVRFLQMARKSLREPKIDTELAYAYAKTDRLHDMEDFLAMTNVADVLEVGEKCFEDELYQAAKILFSSISNWARLATTLIYLGENQGAVESARKAGNTQVWKQVHAACVEKGEFRLAQICGLNIIVHAEELPALVQSYERRGYFDEVLSLLEAGLSLERAHMGIFTELAILYSKYKPEKLMEHLKLFVSRINIPKAIKAAERAHLWPELVFLYVKYDEFDNAALAMIERSADAWEHNQFKDVIVRVANVEINSYYKALSFYLQEQPTLLTDLLSVMIPRIDHSRVVRMFEQIDHIPLVRSYLIAVQHLNLEAVNDAYNKMLIEEEDYKTLRDSIDSFDNFNSTKLLRELETHELLEFRRLAAHLYKKKSKWEESITLSKQDKLYRDAIVTAAASNSSEIAEDLLSYFVDIGNKECFAATLFCCFDLLRADVVEELSWQHGLNDFYMPYKIQRTRSMVEKLAALEKEVKERSKKETEKEQQEAERPLIEPGFGGRLMLTQGNGFPAQAPPPGMMPNGTSFGIPPAMTGFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVY2</accession>
    <name>A0A2G8RVY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11421</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVY2"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL25671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="42213" checksum="9BEAC7CD27E6F040" modified="2018-01-31" version="1">MRSPRLVTDARVPRRTVLRHWHPLPNILNAQTPLSLLPCQTTLTMKSMSQNPQSVLALACQKIACECCGKPRTADRPLKRCKGCSATWFCNKECQIACWPHHKNLSYATIASLSHASKQWAEVHQLALFIIATLLVELRGGGTRAALSSSYSVTFDLGPPRSPAAHDGNPASAFTLAGIEFNDNDQATPGAVAAAQWAPPALALRVAVARRFVLKGTHPDVVGVLPATFYIRDAHLAGQSTIPLLRPHPRARVRARATRGESKRAGGVGGALEFDERTEKALYSLIGLCTGVINTGTVLRIPADAAQAVPDLGRLVRRDSENANAKKGGRCQWRWAPLAPLPQTRDVEKEFFGLREFDPAPVPAAESFEAYHRLWPYHALRVGASRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWZ5</accession>
    <name>A0A2G8RWZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11591</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWZ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWZ5"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="28"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="437" mass="47138" checksum="1CD0958254CCDA57" modified="2018-01-31" version="1">MDTPRSDKTHVATEVSYAGKASKYAGPLSAATSVAPSIYEKGDGVVVETEMLDVPPDGGRGMGVWGVTEEYFKKNVFPDASDSLLSTLGSVSGMFMTLLSVIPGKLADRYGYKQFLALGGVLWIISMLACAFATKLWHFFLIMGPIQGIANALIYPLIVALPAQWFLKYRALATGMVVAGSSLGGGISTLMFRAMLTSLGLKKSFLIYTAIDGVLLLAAWFMIAERRKPSQRKSIIWFDKSFFTDPVFWSLGCCFFFMVFGYLSPIFFLPTFAKEKLPYLSPLLTVLPITMLNFSAATGRTLIGFIADRIGPVNALWIVIMLSGLTQLFVWTFVSTYAGIMAFGIMYGFVCGSFLSLSPAVAAQLYGSGRLAGLSGLLLLFNLPGNSAGAPLGGAILSATGNNWVAVSLYSGSLQIVGGLVLLYARFKREPKVFIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWZ6</accession>
    <name>A0A2G8RWZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIM-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWZ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWZ6"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="10"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="281" mass="29744" checksum="EE7BFFD24D2315EC" modified="2018-01-31" version="1">MAPPTNREEALARLRQTIDSGKIVLGAGAGIGLSAKFIERGGADLIVLYNSGRFRMAGRGSLAGLMPYGDANAIVLEMANEVIPIVQNAGVVAGVCGTDPFRVMPRFLRQLQDVGFCGVQNFPTVGLIDGTFRQNLEETGMSYALEVDMIREAHALGLLTTPYVFAVADAEAMARAGADVLVVHMGLTTNGSIGAKTHVTLDGCVRRIQECRDAAVRINQDVIVLCHGGPIATPEDAAYVLGRTTGVHGFFGASSMERLPAETAIEDNAKQFKNLSLPKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXF4</accession>
    <name>A0A2G8RXF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXF4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXF4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL26196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="82" mass="9501" checksum="3DE945C489A378DF" modified="2018-01-31" version="1">MLSRLAVRSAVRAPRATAAPVAVRFYSENAFNKKEKAHEDQYAREHEKKQLEKLKKQIAAKQAELEKLQKEHDELDGNQEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXH8</accession>
    <name>A0A2G8RXH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXH8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXH8"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="17616" checksum="15838882550B209D" modified="2018-01-31" version="1">MASSPSPPPLFLSSVIDHSLLLVLSTRTMPWIPWSTSPPPRSQPQSPREYLDHYGTQLKSQLPDPLQKHWWDPQDLLAELGRHSPYILLALGAALGLAADRAYVRYLKRIPNSGWVTPDMLKSRRWIKGYVTRCSFSASCAQGARSLRPQTLNVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXT2</accession>
    <name>A0A2G8RXT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXT2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXT2"/>
    <dbReference type="OrthoDB" id="2749026at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="200"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="552" mass="62382" checksum="E8F836AC0C7D3646" modified="2018-01-31" version="1">MWLLSTDRAELHYFARNFDTVGGYAILSHTWTGDEQTLQDVRAIGERCRASGTNPRDDPALSPKIRNCCILAEKHGYCWVWIDSCCIDKTSSSELSEVINSMFRWYKEAEELIAPDFLIFLSDDWHEVGNRADLAELLEEITRVPSRVLTGQYQPAQYSVCTRMFWASRRKTTRVEDEAYCLMGLFGVSIPTNYGEGNEAFIRLQYEIMQRNPDLSLFAFGYCIQQDLALTLSFHAKRHPSLLLSSLLAASPQEFYRSCAYIPDLKQNAKQPYPPRCSDSIPTELFGGVKLPQAAVTSYGIELLVPICETDEATIAVILCQHKGQNIGLFLTRDAGGEDPTRPRYVTGCSCTKPDTGSAQFSARLANLGDDLYNLTFKGKPVKASWQTVYIVPTISDLYSSYSNTPKLTINCNPASRFRIPRWLIAQFTTQKFKVKQITDRDTLQALEIYGNGVVRIKVSFGSCIQHRGHDTNETGKLWAKVDVLLYYADMDTFIHNCSEDHIDSESWATRSKFFGDPDRGVRLSLMPSTRMSESCFVIHLELLGNVLGKMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYG9</accession>
    <name>A0A2G8RYG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYG9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="245" mass="26955" checksum="94A2FF7570617CBB" modified="2018-01-31" version="1">MDPWEQLLASYVAPHQYPSPTPSPPPVLRAIYAREAREARSAQDNSTVRSKNPQTSDLTHSSLTTVSTAVYNNPALTDTTAEIPSASAHQTPGSTQSRASRQQNKHQDQQLRYLERLLHELVHVSRPLSPSNALEAHTHAPVQNDTESRPLLPHVSPPPSKPQNLQKRPRSPEAADWTTESQPKIPRLQISHQSPTLSTIRNRPVVIDLTRTDSPKPSVTSASTLPLHPLPKTLSNPHASANHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYP8</accession>
    <name>A0A2G8RYP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYP8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYP8"/>
    <dbReference type="OrthoDB" id="2802798at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="44"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="353" mass="39669" checksum="731B0E3BC3F7FFBC" modified="2018-01-31" version="1">MQYSFPSTRPPSPPPYTESVPQGRGQGAHVPVPRRDPDFWFEDGNVVVIADSTSFRIHRSVLARHSDLLADRLGSDHDHRDETPDGCPVIRVADSARSFRGLLSLLYPGPSEILRHVASTSDNRVPARVTHKYLHALLPTTFDEWKRREDRALHGNPPPPPSPNLIPNRDMIGVLNALRQIHADDLLPIALYLCAQLPPRLLLPSSSPNPQRPNPQHPSPNGERLARADAERCLRLRESLVKSSARMAMRLFADAPSTDPRCRGCCRAVEEAFDAVVRGEFEDAPRTDPLGAFWRRYIDGHGHGGERGERRGRGDKDNGHTLRVCARCAGVLRERDEEQRRELWDELPRLVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYV8</accession>
    <name>A0A2G8RYV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_11188</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000039">
        <property type="protein sequence ID" value="PIL26709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYV8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYV8"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="69"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL26709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="458" mass="52050" checksum="14461FDBA40D9F6F" modified="2018-01-31" version="1">MFGVRHLSRRLRAGLVASKPRPPSLPRRLSTASFKTLDPSQRVEEEALSWYNPQAFYPVRIGEVLQSRYQVIGKLGYGAYSTVWLCRDLVQHRYVTIKVCTRNAIPVKRELAALQHLDSLPKTRHIGRTLVRTLLDQFVLTSEPAASTDSQSPGTDPDPTPPQLFQCLVHKPLLMSLFTFRNGNKLPEDFLKLVLQHVLLALDYLHSEAKLIHTDINENNILLDLDDIITALEAFEEAERTSPVARKDAGDRTIYLSRKIVTASANYGRPVLCDFGEARFGSATYTDPIQPFQYRAPEVILGAPWDEKVDIWTVGVMIWDMFEDRNMFKVTGGPDKKVDDLYHLAHMVALLGPPPVDLLQRGTMDDIGRYFDAQGKGFLYRSFRVLPHRLVWVCVSGNWVGATSLPDDSLEQSERNLEGEDKALFLAFVRKMVRWKPEERCSANELLDDPWLNKFEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ07</accession>
    <name>A0A2G8RZ07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_11149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000038">
        <property type="protein sequence ID" value="PIL26735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ07"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ07"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="10">
        <location>
            <begin position="112"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Importin subunit beta-1/Transportin-1-like TPR repeats" evidence="9">
        <location>
            <begin position="520"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="279"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL26735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="918" mass="100662" checksum="58D20F13E4BE23C8" modified="2018-01-31" version="1">MSDVVVPPEVTAEVTQILSNLVLGDNQIRSSAEKAVDERLAQTPELYLLAIAQFATSADTELMRSFSLVLLRRLLFRPSTSQRVALYDHLASQAIETLHRILLHSLLHEPAPVVRRKTVDTVTDLSNNASKRGYPWNALRSQVFAMADSAEVLTREAAFRVFAGCPNLILDLHVEDTVNLLQKGLQDPQSTEVRLASLRASVAFLTACDLTQQAQALALMYPMLNTLPSVPHTQQPPFLSVLTELASSNPHLFRPHIPALLSFLPSLLLPVVDAGPTPTVARPNPGGGSTFAFPPVSSTGKGENGEDRESGEEDEVRKGALEFMTTLSEAKPNMLKNVEGWVNIVVRGCLEGMGEIPEDDTEAWLDADPAEDPTDDTYPHTYEHSLDRVACALGGAAVLPPAFSFIPAMLASHDWRLRHAGLMAIAAIAEGTSKVMQQELGKVIELVTPMFGDQHPRVRYAACQCIGQLCTDLEEVVQEKFHEQIFAALIPALEAPEARVHAHAAAALINFCEGVERDTLIPYLDSIVERLLKLLNPAASDASKQPKRYVQEQVITTLAMVADASEATFAKHYSSIMPLLLNVMQNANGPEYRKLRVKAMECAGLIAIAVGRDVFRPDSRTFVELLMRIQNSPVDPKDTMLSHFLIATWAKVCQALGEEFEPYLPVVMPPLLRVASSKADISIYDDDEEHEDREGWESISMDGHQVGVKTSALEDKCQAFETLLIHASTLNARFGPYVSQVLELALPGLRFYIHDGVQEACAMLVPVLFSCGKNSGTLSQQMVVATFSQLINCIGVETDSSFLASLFKCLLDTMLVIGGPGSLAPEFHNGLLEATKRQLQAFADKRKARAARPAQELRDDREDLMLIEEMEDFALEDMAKALRTLDPSHPLLIAVSSVRDLGLHLSDWEGEEDGVVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ08</accession>
    <name>A0A2G8RZ08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_11174</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000038">
        <property type="protein sequence ID" value="PIL26759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ08"/>
    <dbReference type="OrthoDB" id="2752194at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013735358" description="CFEM domain-containing protein" evidence="15">
        <location>
            <begin position="23"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="94"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL26759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="222" mass="22268" checksum="83B92A67F24BBB18" modified="2018-01-31" version="1">MHLTLFSAAIIALTLPFAGVRAQLPPQVTPCIENCLVEAAAQDLDGCSVSDVQCLCANKKIQQDALSCLQQQCTTQELEEVQVFIAAECAPAASSSSASSSSTHSTGPSTSVTHSASSSEPHTSEKTSISSTTTIPSTHLSSTTSVSATSLANSTTSLVSTSFTAPLALSSSSPPSSSSATSNTTASAAPARTNAAVRAGQDSIGIGIAALGAVFGGAMVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZB2</accession>
    <name>A0A2G8RZB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZB2"/>
    <dbReference type="OrthoDB" id="2793474at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="307" mass="35830" checksum="74799FAF6B37B1A8" modified="2018-01-31" version="1">MSSPFFFVKKKDGSLRPVQDYRRLNDITIKNRYLLPLVSDLMDRLKKAKYFTKLDIRWGYNNVRIKTGDEWKAAFVTNQGLFEPNVMFFGLANSPSTFSALMNDIFKDLIILGKVTIYLDDILIFTNDIEEHRTLVREVLKRLAEHDLFCKPEKCEFEQPKVEYLGVLVSENHVEMDPVKVKGIAAWPVPQNALDVWKFHRFVNFYRCFIEDFSAICKLLDCLMGNAPWKWEAEEQEAFDELKHRFTESPVLSMYNPDCKTRIEVDASRYATGAVLSQEGEDGKWHPVAFHSESMSDAECNYEIYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S092</accession>
    <name>A0A2G8S092_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S092"/>
    <dbReference type="STRING" id="1077348.A0A2G8S092"/>
    <dbReference type="OrthoDB" id="2730708at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047655">
        <property type="entry name" value="Transpos_IS630-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033545">
        <property type="entry name" value="transpos_IS630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46564:SF1">
        <property type="entry name" value="TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tc1-like transposase DDE" evidence="1">
        <location>
            <begin position="146"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="308" mass="34849" checksum="26288F2D6595FE16" modified="2018-01-31" version="1">MPPPISDDLRQRIIAWREEGIPVKSIAELAGCKDRVVYKILATHRDTGGVRYPPSFRPRGRPRTLDNHDIDYISGLLAANPTLYLDEIQEKLASARGVDVSISTVSRTLNRLALSNKQVSKVAVERNEVLRATWVAAYGHIPKEYFVFLDESSVDDVTGQRQKGWSQIGRACVRRATFLRGQRYSILPALTVDGLIALDIFEGSVNKEKFIHWISTELAPLLNPYPGPRSVVVLDNCAIHHDAEIRRIIVDECDMNPIEQAFHTIKSWLRRNENRVARPEQRPWMIHQASLSVTPEKAVGYMINCGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0B3</accession>
    <name>A0A2G8S0B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0B3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0B3"/>
    <dbReference type="OrthoDB" id="2953893at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="175"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="339" mass="37563" checksum="E427AF98B77F8E97" modified="2018-01-31" version="1">MSDVQDQPPLPASLLLQIGPPFIGDLLAWMLFGISIVQLYIYHTSFYRDHIAIRAAVYFIFLLEVFQSIIVAVGGWQVVVAGWGRLNNLEYPGWSFPATPIVSVIISVSVQTFYAWRIWRLGGWRLVPLAIITTGLTSAAGAFAFSILFAFKKNIETFHETIMYSLTTVWLGVGAFTDILIMTSMFYFLYTAKQRVQHFESSELIVNKLMRLTVETGLACALTALIELALFLGLPKTNVHIIFATSLSKVYSNTFMTSLNSRASRYKQKSSGAINLGSYSGTTITDQLSSGSNPPLAIHITQRTDKGQNWDMELNDLPSSGSEQHTVTVSGKRSDVGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0R6</accession>
    <name>A0A2G8S0R6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0R6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0R6"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17764" checksum="5F31BEDC5F8E6042" modified="2018-01-31" version="1">MVLPHNLCSHVQNAFRARHQHIAVHHTTQNLAILSILLRAGFLSNVTRGTIEEPSPEAFLGVPESQKRIWAKLKYRDDRPVLSDMELISMPSKRIIMDLSEIRRLCTGRRVQNVKPLRMGEIAIVKTKDRENEWVEAREALQLRLPGEVICRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S161</accession>
    <name>A0A2G8S161_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S161"/>
    <dbReference type="STRING" id="1077348.A0A2G8S161"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL27477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="544" mass="61600" checksum="07C65AC6A3EE3C16" modified="2018-01-31" version="1">MEGVSVLQVAVATVIGYISWYLLKPCVVRSPLDNVPGPPRQSWLYGNLTQFLTQACWDFRDELVRKYPGRVIRLHGVLGARMILVWDVKAMHHIFIKEQDIYEEPVGVKRETIGTGEQHKRQRKMLNPVFSVKHLREMTPLFYQVIHRTRDAIMTRVRADDASKDGVELDMVSWSGRTTLEVLGQAGLGHSFDPLTGDRADEFATAVREFFPQLVRSVTFRTLMPHASKLGPASFRRWVVERTPLDYVQQMRRITDTLHDRSVKIFREKKALLEKGDDALKHQIGEGRDIMSILLRANMSASENDKLPDDELIGQVSTMILAGMDTTANSLARVLQLLADHPEVQEKLRQEIFQAVEAEGDGDMLDYDKFMELPYLEAICRETLRVYPGVTILFRNTAKDVILPLSEPIRLRDGTLVDAIPIPKGTRVIPNVGASNVDPALWGPDAHVWRPERWLEPLPRAVEEAHIPGVYSHMMTFIGGNKACIGFRLAQVEMKTFLLVLLQHFKFKPSGKKIIWNFAGVQYPAVGEIGSDPELPLLVSPLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1F0</accession>
    <name>A0A2G8S1F0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1F0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1F0"/>
    <dbReference type="OrthoDB" id="3256745at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013788952" description="Transporter" evidence="2">
        <location>
            <begin position="32"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50429" checksum="C5BBA83A747E7BC5" modified="2018-01-31" version="1">MLAFGFKVAWFTLSLLGFLSNLLAFPAFAEALDGYIIPSLYTGSNFVLQGIFCLGMIWKMDPLAMPRAFCTVQPAIFTVAWLFTTFVTSGMAVCSTSAILRPKGGVPATPMFVHSFGHTVDHFTPVPLRRQSRTKANSVYHEAKTFDPSLWSAEASPISTGLPADQRSTTPSGIIVEAIPSPPDSLSSGRVRVIAGRAPAIRRHDLRYHLPFQWRFNEPLNSADGFRSSPDSSLKLSLSDSRHTPSPLIFANPVEERNQYTTTVAVVSDPSERLYEAAPWLKDEKVLLRQMEKVNRSLARHHCPWNTSKGFIHDDDEDYDAVSRELRWARHSSGSISSAKSELEFARRPPGDNFEEGVRRPSPAELSTYDAALTETPIPDFTSMVWRILFFQLLSSATQIVATFSSLVDMSKQHALPAPFGTQHVALLLTAWMPLIAFGVRWPWWWRERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1J2</accession>
    <name>A0A2G8S1J2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1J2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="195" mass="21225" checksum="3070DF7F518318C3" modified="2018-01-31" version="1">MVWKGKVTGAAVIFVLNRYIGLLNTAFDAVSAIANLSDEVRRDLCNALKVCNIRSNGQCLDRNLVYDLGRFKTAPLGGATSVNFGKKSLLHVFLRNETLYFIIIIALGLVTFGIYVLQIADIEKNYTYLSIFTTAISNILISQFLLELQTADKRTRAGGSLLSSTNSGISTVVFDRLIGPIGLASVTPEDEDEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1Y7</accession>
    <name>A0A2G8S1Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1Y7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1Y7"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="135" mass="15217" checksum="76272971C61DF83F" modified="2018-01-31" version="1">MGDSSDSSSSEDQDEAPSPSSHTRKRRPRKPQRHGSNDETLHDGSSAEIHVDDVPYSRKAGRRRRRSKRSTDIEMGVVENREGVTKKRGLTLSKVGGWRGWEQSMPADAVLTKEGVDEFLQSVDRAVMHHPRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S230</accession>
    <name>A0A2G8S230_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S230"/>
    <dbReference type="OrthoDB" id="2332199at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="284" mass="30838" checksum="F194C07607C37AC2" modified="2018-01-31" version="1">MWNIMGNDLSRARALTVTSLLVNFGAQLYGMITTPNMKDVADMNHYAFSPNPYFIAVFVTGQVVLQLAWIRKLFVDDPPNGYCVIAQNPPSPTAARESTAMSPVTDQEEDRAWKAAVMYAPVYAIGNLCIVGWLFFWLHEKFVGSQVLVTVNTLLQLAAVVALPPAQPTSPALHKLTHVVAKTFAGIAVLDFLDNGAIAFRYRPPPSSVVQALTYTFFPLAAACSGPLFAAVLLYDVLAVAVGQTGVEGATPWPQRLGWTTLATAIILGVKFATRGSQFFHHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2G4</accession>
    <name>A0A2G8S2G4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2G4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2G4"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="331" mass="35160" checksum="27CDDC26F6A15A01" modified="2018-01-31" version="1">MALGTNAQTAVEVTRSGGFGFVGAALSTPEILKQDFAFIRTSFPNLEPNKPLPVGYGFVGWLLDKNEEAGKRMIDIVIENGVQAIWLAFGNDIGRWVDYVRSSPANARAHRDRRPLIFVQVTSVEEALVAANEWKVDVIVAQGTEAGGHGGSATPSTFVLLSEILAALPQDGTAPPVIAAGGMANGTQVAAYLTLGAAGAVLGTRFLLTPESPYTDAQKAALLAARTAGPCATVRTLALDYAGDTAYWPVHINGRGIRNKIVDDVEAGVDHATVQARCKVATEVGDQSYMIVWAGQGVALMNEIKPIKDVMAELHADLVKQLQKSQRLLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S386</accession>
    <name>A0A2G8S386_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_09648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S386"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL28236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="536" mass="59612" checksum="662CFC3377A98B23" modified="2018-01-31" version="1">MARLSSWVHPSGWVLEPEPSTFAPSGRWSNKDMDPVPPEKRTWSTINYVAYWVSDAWNAPGWQLASSMLAIGLSWRQALPAIAVGTSIISVVMVLNGTVGARLHVSFPVLNRSSFGFWFSYFSVISRMVLSMFWLSVQAYTGSQCVYQMLKAIWPSIARMPNHLPPGTNITTSGLMCFFLYWMILMPFMFVSPQRIRWLFMLKAVIVPPAWIAMLIWAFVKVPSNTALLDQHSALSGSALSYAWLLAMNSALGIYATVAVNIPDFTRYAKHERAQYIQLAIIPVAFTFGGFIGIAVTSAGATLYGKVLWNPLTLIDHWDNRPAAFFAAFSFALATLGTNVSANTISAANDMTVLFPRYINIKRGQIITAAIAPWAFVPWDIVSTAQGFLSFMNGYTVFLGPFAAIMVADYWIVHRCKVDVPSMYRPYGRYRYTGGFNWRAVVTILVTVPPNLPGLIASVNPAIQIGGAFKIFDFAWLFGFFVSLVVYSCLSLMFPAKETFVGEIIAKDQQSPEEEIDARSLSESKESIPRDTKNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3F5</accession>
    <name>A0A2G8S3F5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3F5"/>
    <dbReference type="OrthoDB" id="2750727at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="299" mass="32372" checksum="59B7551A7F22007F" modified="2018-01-31" version="1">MFPIVSQPQPGPWDPSAVSLTFGGVNAYIAALWPSIILLLLSTALLGLFTALALFASLVLVRKGLREPQNSILLMVILLMYASAVLHWVTLLLNVIGYYNVSRAYATQMLCQCTNGDTCRLLCPVILAPEVTCTMNSFGLPGAVHGLAVVLGDAVVWWRVWVIWPRSLIVRVICVALLSATMAMGIVDTSDSCSAAAFSTVSVYNLTYIPSGSFYQSDLFGLAASVLSLATNMVATILIGCKAWEHAKIMGSVSSLKRSSRVEKILIFLVESGTIYCIIWVCTPNHFIGELRAPESETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3Q5</accession>
    <name>A0A2G8S3Q5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3Q5"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="280" mass="30681" checksum="051D2E178BF2EE6D" modified="2018-01-31" version="1">MNVYAIGASKNIGYFAGLRLLNQGATITYLLRSPSAFDNDAEMLHFIKDGKVKLVRGDGLKPDTIREGWQKALEVGNGKIDVVLFTLGGKPTFSMTCGFVFNPPDLVCRSLMNTFSTIPDELRAPENQPRFIVITSMGITSVSHKALPLALKPLYGTMLTGPHEDKLGAERLLSHVRGLPWTVPDEVKKEVLPDGWQNTPGLPKAGEIRQLVIVRPALLSDGDCKGDGGRKKGKGPYRTLKDADFGDGYRVSRKDIAHFIVCDALPNWEKWEGSGVTVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3T7</accession>
    <name>A0A2G8S3T7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3T7"/>
    <dbReference type="OrthoDB" id="2758182at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="731" mass="81223" checksum="5C0C547D6226AE0E" modified="2018-01-31" version="1">MPPQAKPPKPTDLTDTETAYLESCIVNYRSTPTGDKEDFRDNCVRYIMRGRSLADHEFTFEHFSTKVRNWFQNHTGKGKTESLPININQHISAKRAWAIVNEKTIRESVEKRKAEAGGDERFHLNTWNDVVRQLWEEVPEAEQAVYECLTQKWLVEGPDESVKSIIAQKRAPKWLRSVTHLFWHQCNMPIFIYGMYKDKDGDLHAAVYDTSKLWREDDKTTPLLRNILGWDQDFRRVAWNFFQATLRPDLAAAETLQVMKAAKRLPPATFQFNVYPDKCPILVDTENGKVIKGSRMQEVFREYMKAHYNLAAGREMRAPPWGSLTTNTSKFFAEGMLPDGFQFNDPSHINAGFLGDFYTHVIEMEKADPLRRFRFSHYEIGSGDNRQYHPAVYNGAVEAAAPRRAKKGIAVPEFEDPPSPPADDNTSLTNRSTASPAPVPLTVVPPLQDILAAHLQAARIELEAERTAVHGSQSDGGHMLNPTHSTTPQLGAANHPSSPSEEAMPWLDAEIDAAAHRTDNEFGLTDDEFIPEPTYDDGSDDEVENVLVAELVREAASVLSTRNADSHAQRPPPMPHPIVMEGSSTAAVTPAPAPSTSQAAGPAGAIATVVQGPLLPPCDAGSSPSSRLVYLQGLADDAEYIALLERLQDSLQVVVPVRAQNPVFWGTWGHRSPHVPQAVHASEKKTGQLLQWISKTRDTSGSAADIQRFCLVIGLTLRDMSLLASIDGTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4K9</accession>
    <name>A0A2G8S4K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4K9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4K9"/>
    <dbReference type="OrthoDB" id="2762307at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="131"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="306"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="743" mass="84354" checksum="57B83CEAA4E7D99F" modified="2018-01-31" version="1">MRLLDTLTGQFTDANLDETQYAILSHTWDEEGEQTYEELKKIQRRYVGRRRASKSLRATLSSHRPSQRLTLWLNRITALMLDIRSSDNEANIIPLCARLLDPRTPAWHLNSSTLPQELPSKLFRGCIWDDRRLSPKIREACAVARTNGYRYVWIDSCCIDKSSSSELSEAINSMYEWYARADVCYAYLADVPPGVDHQAEDSFFRKSRWFTRGWTLQELIAPRRVEFLSKDWAPVGSKHVLARLVENVTKIDYKALLHLESLDNFSVAQRLSWAANRETTRREDRAYSLLGIFDIHMPTLYGEGDRAFRRLQELIMQRLPDQSLFAWGLLYLDSRFSSNPDLAYTTKILHAKPLPYGQRHLLSGSPDSFKNCEAVSTIRRDATTTLASSSHRSKIEYASTPYGICTQFQMIPLTRDLLLRVIPDAEDVQLKFDAPEDYRWYLAILECEHAERPGDRLGRVCYIPPSDSDVEFVYTGSIVVSSERNYSSWPSHLFPLSPETIEYCRSQTELKTVYIPHPDRRDLLWSLQLQPYTSIKLVLLPETRDALRSQGYSASLSDPDPDHPTTQRLALSNDEHAIAVEFQHVLEDDGEAFTIDAAVEMSVHLRVDSGTGTMDSDRADRPTVSWTDSSVFGWRPRLDFERVMLSALGGAGTVTVDLALDFAGAGSYVLRVEIRSEASRTSSAVELPVGGDQRSEMGRNGERDVPVGEVGTEDEGSVEDVDEMAGVEVREAAVTRDRHCQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4S0</accession>
    <name>A0A2G8S4S0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4S0"/>
    <dbReference type="OrthoDB" id="2570975at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="436" mass="47593" checksum="4197BE27D420F3C8" modified="2018-01-31" version="1">MVTLVQPLGKRFLIRKCSNAENLPPSASSKKADALVSAREASRRRRARVVSGNLPLKVKKVVHNAQRRASKAAHLSSKPLKPTVSLASIHCSAAPLASEQVIEVSAASEATTAPTPKQAEVKPDTLNLPRFLRRPPSSVWPVDFDRANIDACSPELEGVDFSYIMQGLEVTGPSMWNLVKTAHIDRTSMGRRAALPDEVNVIIADHAALCTPANIAPSHPTHVLAVWELPHAHPVHRKSAATADARRKVSLIPAHNLVLAMHCAKWFKLGPTNTSETRVLDPQGLPGTQITLPIVPLAVPHPESFLLLLQAMYTHKASWLMDQLVPVQKPAVAFPSAANPAPENPHYILETGRRLAARYTPSALLEMVGTVVGLWQNAVYLGVSDRRLWTAMDWSYDMLLTGLGFALRRPDLVPRPQMGSFRWTAVPQASECKAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4W0</accession>
    <name>A0A2G8S4W0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4W0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4W0"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="463" mass="48262" checksum="A5E21E52A7EF7178" modified="2018-01-31" version="1">MMWLLTTAQAASTLRFNNPSIPAQLLCSKVTFSWSGGVPAYELQIMDATTEAVIEDFRGTAGTSLEWVADGKVEGKNVVAKIIDSTGQSAITKHIPVSPGSPNACPQNIAIPSSAPSTLSFTTIVTITPPSSAPSSRATIETTSKSSPRDTSVSQSPTGTRPLPSSAPDAASSISSASTTGASSTTTSIPVPPVPSSPPASAPAPTQPPSVASSTALSVPTYKSPPPASPSPAKIKPPSKAAIATPIVALVVGIGAILLYWLCRRAAQKRKVVRSSGRRADLDLQESCPLLSEPAAPGRAVVARRAWAGPSLPWRSSEQSAFAPDDENDILVIRRPRPRSTDAQASLWQSDFASAATASPGYTSFLSATGTGTRPWGPKDRRTDSPIDSLTSLFPAGSTRPSSQYLLSTHRDVAAYMSDGRPTGMETGSPSGFSKPLDEGEWDDLSDTGTTTTLPPPYYHYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5C9</accession>
    <name>A0A2G8S5C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5C9"/>
    <dbReference type="OrthoDB" id="2570975at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="137" mass="15492" checksum="8DABA47D556296BB" modified="2018-01-31" version="1">MVKCKYITPKHRAYAATARVNKLVLPRALFMAAKYRARRALPTHSAAWNGLKNRSCRQTDGGLYSFSLERPPIPDIDPERVAYTQPQFKGLPPAHIRGHVGVHELLMGLYDRIFVDPPKTRLPSWYNVVIKDLGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5W5</accession>
    <name>A0A2G8S5W5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09219</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5W5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5W5"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="846"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="862"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="916"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="939"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="964"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1110"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1155"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1197" mass="126036" checksum="670FBABE3E5BC694" modified="2018-01-31" version="1">MHFPSPTAPSSSTIHASNAQATEQANGGAGSSQAPSGPKFSNGPHIRSRITVVCAECKRLKLKCDRRTPCSSCIKRDTVQRCVYSQAAAEKVDVQTLHNRIIEIERVLAQLQAAAPSASVSTALSTFKQPTPVNTGPSKVPASSASSSSLLAGFPCNDRALLAQGASGSSVVINLEDVVSLWLSELEDFGSDSKARTSGPDASGPTRPSSSTTTVKLEPAPVSIPPAPSASFSPGNGSHIPIGGFSTLHPPAPFESFLPPASAGPSALPQVTAALVSYLPSEPARSYYLKAFRETMLLHPSFNVPHFEQRIAAVFSWAEIGESAPTAVPAYGKPPMSKQDLARDIFFSSAKPNSAPSRAATGPGGPPGGPGPGSNTPKPTLSFFSAACSAFALGSLVSRDEGHPADEASPPGSGTGAVGETSGTSAMLFALSEQALQLFEKTAAYDLDSVIAMILQVLYMLHEGGMSVAQSVFPLVGKMVNVARMMGLAMDPDEFPGTYNLFEAETRRRVWWEVYYYDLFVADAMGHPPLIADNTHTTRLPADVEEDQFTPSCTSLPVPEDIQGDSSSIYFCLKCRLAQLVKNVKKQTFRDPLGGNDEAPTELSIDHAGMFEAEVTSFLQELPAGFRLEMAQDLSTPVSPLPAPGSGLPSAIRVAQKCELVILANRLVVKLYLPFLKEAAAAGRPSHQAVFGTINAAHNIICAARTLHGVWGQTRPAVFDFYDFGRTLFDAAVVCAHAVVQEPGSIIAPEGMKSVTCALDILKELGSSRVGVEGSHGDSGANSRGEAVKIVEMMKRKAEAARSGGGVVAGTKRKHAEVEGETLAPSSSASFQLPFVGAAVSSCKAERPRAHRAGGATAVNGKDAEKAKSEAKKHGKEKEKKDDKDKDKDKASKYLNGPLRMRPMTGQPGSSRRQWTASVSTTAPATPTPTATATATATAPPPQPPAPVPVPRVAPAPATPSPPSVSVNVSPPLSSSSQVQASSSRASVSIPDPSPMTASAPYDAYPPAPPVQEQPQPQDDYVMQYSSPDSVTDDRRYSAGQSSYDSPQSAGTMYDPQPQPQPQYAQSPVTAYPPPQSQPQGGYYLSYPPPPPPGTPGGYEGHAAMMAMMAPPPPPPPPSQAEGGIAPSMTTISHTYGPPRQIEYQTQPPPPPPHQHQHPHSHPHGHQMMGSMQGWAPQSEQVWPKYEYGGVNPGWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5Y0</accession>
    <name>A0A2G8S5Y0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5Y0"/>
    <dbReference type="OrthoDB" id="2737129at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="213" mass="24006" checksum="CC7D0477E1295191" modified="2018-01-31" version="1">MSSLNDSSGPSTTTAALPEPCDLLLDHDDSEVSDNQSESSSRSVTPEPKRPAQAKNKSPPFPFEYGKSRVRKMLPRLVLPRLLDPRCVAIQAPTDIPLCWLGIPFSFASISTWAKNSGLGVPCTEGYYSRIPGSIDVMKSWLALLDHFYEETGITIDIRDVWGAEYPILAFISNRQTCDITMDQHRAIEDVLEDMEFDKEEGPMWYLDKRELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S631</accession>
    <name>A0A2G8S631_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S631"/>
    <dbReference type="OrthoDB" id="2638860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="363" mass="40969" checksum="0B0374AD700A00E7" modified="2018-01-31" version="1">MSLLGLLPKGVSIIQAEQLFIQAIEDTFVVNLSAAAAATWVAYDITLTFGDEVTFIWRAKWTMQKVMYFLVRYYGLFALLFYLSGEEDRLLVTQPLLTRVSKTLVNNMRPIRYVVDGHITKPSFPCVLFGEAMFLFRLYAVYERNKRLLGLIVFFYIAGIVTAIVTGILEGRLIHILPRPDHWPMPGCFTLASVPLTISLGAWVLNLVTPTIYMMLMIYKLMTGPTFRSDAFARRDPIGELSELRRFSPLIYLLLRDGIFYFVMVFLVNLANLILFVRFNGRALEGVGVAWLMAVYSVASSRLCLNLRSFAVRPPTQDEDSESDPSSDPKAIMLSTVVDLTGTASYSFGSSRQTQSTYTSWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6E5</accession>
    <name>A0A2G8S6E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6E5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6E5"/>
    <dbReference type="OrthoDB" id="2755864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="2">
        <location>
            <begin position="305"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="433" mass="49115" checksum="DB5677FD6E1E8333" modified="2018-01-31" version="1">MASDAVRLLEIQLDVHKRSLHEKAQRIDELEARNIDLEAQVDHLKEVVAKHQAQSKDRLGPLADLNHKRESDRDTEPETGGLSSKRRRLSPQEVVQPHSSNSNHYASRSGGQSATADVRDPNGSKHGASQPPVYQPRQSPKIVPQQPESTQEPVLPRRETLLSSSRAHPRVDPSTELELEYPVEDPGSESDPSYEPEDEDDGHTQARLFERPWCTYRLHSPHRLTLRQTSRAAFSPNPATAARLASIEPFEHGVVAKELLASTAERKAIGRRLDCKGKKTVIYRQDGTAFLALRGRLFFSALLNEWMLSGTFQVFVGLTPGKWKYMGHYALQRMHPLEGGEFESLPRGTKSHWVKDILEQKKYGTIRKDIHRRGIYGRAINAQDIIKALEQGEELKNFHVTQKLFVWRMKCIGFDYNLLRQATGVPSEEGHYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6M2</accession>
    <name>A0A2G8S6M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6M2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6M2"/>
    <dbReference type="OrthoDB" id="2764751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="791" mass="86302" checksum="3E5A6FC5997BF5B7" modified="2018-01-31" version="1">MSSSKATRVRRAASTGAKAPSGRLPPPVLSDSDDDGQDRDPVPPAPKTRGRGRGRGRGRGAPVKTESDSEGGNDLAEVKPSKRARALKALPDEEESVSTQTPRKRAGTIKVEKIDPPPVKRAPSRASKVVKSPEIVPSTGDEDEDEDEDEYKDDKPVMSKVKSSVKPRKSVVVKDADDVESTEKTLQKTPAKRVVKDKPSAVAKMRTKAPASIDSEADAHRPDSRPSVMQTPKVQRVREDDVDAVSPESPSPRKLSTPHKARPTRSYGKSMSQKRPVDVNSSDDEADNGKGHPSPSKKSRKESPEIAYMPTPRTIRAVGFSQQPEVVITTKRNAQASSKATQDVHKDTRKKETSPVKTHNPPDSASDFFTSAPAKSPKKGQGLFSKRQSIINNEVEESAGEEDSDHGSAMSVDTEDHVISALSSPSAEMSEEEEPKRVAKKKSTRKAYRSPTPGVDQDLDEANDAASQINDMTLVTPKKGKQRAQLEEVKKEGGPAPHPLLYSWDDVIDIAKDPAAADLLPGLNAIDLDLDGGDLFTVDVHESVLDVPWYKVHSIGLLWTIGLASGDKLYDLAINPSRASLHRVTTIPIGKDGKDSLLAIRTETGGHRAVCFTINIVLQSDVLAPTTAYRTKLVKQILLAPFDQEWLRMGYFLGNAFGVPKLKIPHYKARGSQVDGLVFKTLPKDDPRKVLVEPEPSFKLMRAGAGKRGQSGRANADPSAPPAPDANPDQSFQAMASTTVWPTDTRIPLWDARNELLDNKQVECGRFTIDKTFKLPRLTEDLRYRDIALVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7D3</accession>
    <name>A0A2G8S7D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08121</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7D3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7D3"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="435" mass="47327" checksum="72F6D6E2C0453F58" modified="2018-01-31" version="1">MSSSSSTDKEKLSTEKLSAEIVTVEYVAPSPSVAVDHKKVLRKLDLRLMPSVCLLYLFCALDRSNITNAEVAGMGTDLHFTGVQFNLCVALTLSGLLPGVTYYLCAWYPKFAQAKRIGLMYSGVSIAGGFGGLLAYIIQDKMDGLGGLAGWCWIFLCEGLMTVVIAVILFFSMYDYPENATFLTDAERAWLLETLKLDSAAGSKKFKRKFIVQAIKEPKAYLFASLFFLSAIPGASFSTFLPTIINGMGFSSTNAQILTLPPHVAGCITTLFVSYLSDKKHFRGPLILALCPVAILGYALLISTRTLAAQYLGSVLVLAGLVPCVATQLSWMGGNFAGLLKRAVVIGMVLGFGNIGGIIAAFIYRQQDSPRYTLGHTICISSLSLFYVMCIVAIVTLHMLNKRKIAQCERDGLTLADEDTFAELGDRSPLYRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Z3</accession>
    <name>A0A2G8S8Z3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07639</name>
        <name evidence="3" type="ORF">GSI_07795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Z3"/>
    <dbReference type="OrthoDB" id="3256283at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="275" mass="29696" checksum="EC961B7BD4AE3E56" modified="2018-01-31" version="1">MPPRANSSKKRACSPDEPKPADKPQTRSSKRVKKDVTSTASTSTSLSTTSAPAAKSRTRPKAVNVVEDSAVAPSFHGNFDLYAMSLPFLSSVFAPKRDYAALLKTIRTYQAKPDNTAQIFLPEDTSKSGRFESLAVLDPIQEWPFDLALRSLARKPTLTFTAREMSDNAKFFSGAGAGSPAKGPGVTAAVALAYDQCGIASSKGAFKMRRAWVSADGRDEVFEGVFSVSIIYSSLYRGKCDETACRETFAFWGVRARVGEDGKEIGLGPGTGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S918</accession>
    <name>A0A2G8S918_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S918"/>
    <dbReference type="OrthoDB" id="3232438at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013876657" evidence="2">
        <location>
            <begin position="22"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="216" mass="24234" checksum="17F0B2A0686FF565" modified="2018-01-31" version="1">MRTSAASSLVLSLGFLSGVVSHPCIWYVPYVPFLTSSLQRFHANKAIIIDLGIRDHFHFPKLHSLDHYITSIKLFGTTDNYDTQHTERLHIDFAKEAYRATTRKDEFPQMTLWLERREKVLRHGAYIQWHLSRFISGPSDRGDRRTAASTSSTSSSESSLVPLHAASPPLPCFPSVTQPQPVPTRMKLAKWPTVKALTFPAATQLYGAVFHVGGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9N0</accession>
    <name>A0A2G8S9N0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylserine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9N0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9N0"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF13">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36751" checksum="75D7A4C8FE6E640B" modified="2018-01-31" version="1">MSYTPTTAIVRELVDYFSENPEFKAAFEESFATAYATGLREFHTFKIHSVDDYLRYMDEYVHWIPSENLTGTNVYSHLCMFYFILDLPPVRDHQSPIDPSSHSPWRWLSEWLIMYAKEMGMWMDMPDSITPEMIETFVKCPAYRDKGVDNFYDQYPPPFDGWKTFNEFFAREINPTLRPIAGPDDPTVIVSPADCTFDGQWPINDTTADVTTFDVKGVPWTIGQLLDDEAAGTDYGPAFSGGIFTHSFLGPTDYHRQHAPVAGRVIEAKIIPGLCYLEIVLKKVEGGIRSSACTVTCGTRISTRRISSPQRPPTLPGTSSSRHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9W9</accession>
    <name>A0A2G8S9W9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1766-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9W9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9W9"/>
    <dbReference type="OrthoDB" id="2417614at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13455">
        <property type="entry name" value="MUG113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46570" checksum="7EE876897A3772E0" modified="2018-01-31" version="1">MQIDGPSYAANRPPNSAPAFPVPALPTPPGAPSMPVPQTSLTMQYALTGSDAPLGAPPLPPPPPQRKDTGQSLSLKVPGSGGRLRPHSDSAAYPHGNNNNPSTPQRPQLQQAPNSAPAKPRPAVSPLQTPSRRRRASSSPPSPSAASSSGGSTSGGGGKGGLKVQCSGTTKQDKRCTRMVQVSVPLARLNADGDIPHYCHQHLKGAFEDKKFWSHKKPSVEVFYDEWIPEYLQEDTRDSLREQMRMDPSTADECGFIYAFEIDDPTDPDMFHIKVGRAVKLTKRLHEWDKQCQSKQTHLRGFWPSTPDADKGNLARGRVKVGDPGQYCHRLERLIHLELADLAVNAPYLDNDYPDVKGGNGSGNGRAVVRKACPDCGAMHKEIFSFRRAKKGQFKGKEWEEIVKPVLEKWGLFVETYYEPLPLPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAR4</accession>
    <name>A0A2G8SAR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAR4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAR4"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="101602" checksum="8D9193DAE1E2312A" modified="2018-01-31" version="1">MAGPASPTMDEAIRVVVTPSQASYFAGEPFSVTITFTNTRSPETPAPLPRSSSQFHRRGAHSISSVPLARPPTSPGTPRTAVPVFLPPRTNGQSRTSSSRKGLIGHSLLAKSKSPDEPPSADVLRKRFLASRSLSISISPNDLPVSNEAKEPSSPLNRPVANGTSNSPIAGPSSPRVVAPLARTPMLPPNHPHARKQSLLDGQLQLQDLRPPPTMSPFAPSPNPSTSTFSLSLDPIAEAGSVSPNAPTTPYIPSPVLNPDLPNVRKQIPSGPSASAMANGNGHPPHLDGPPRGPPRRPPQLGLGHGPPPAASPTAYLKPPRTAFSSSFPIANTELILYAYAQLLGTLTITPLPDTPSSPDQSRNLNRLRTRLLKRKAVGGGSMDISSSLSAQPGSPTSPTRRASHGRSSSLSAGLLSMLAPSPPGPQSSSQPFVPGHRARTSSVFSLFSNGQSPPPSGRSAVGLGFSTSTSEDDEVDPDQPLPTLEVQPSMLAVDLSLGPGESRTYTYTLNLPENLPPTFRGRALKFSYQFVLGVCRAGGGTLGASLSSNSRVMKVPIRVYNNVAVGRPLVPYDLLWPVVSQRAPISSGKVTEGSKEQKKRTGLRATPASCAKPGTYEDLQGYARNLLASFPDPKATGVRIKLPIEAMQHGNGDVERELEDDIDSPAGCRQAVEVLTRNPKKASYDVNKDGVKVAVLTFPKSAYRLGETILGVVELNERHHRARVLKLSAMLEAHESLPSSIGSPTLSRQMRRVHAEHHSCFMSATLRMTFSLDIPPDASPAFEAAYEEPHLDVDPVNVRKPKPKSGGLEWKVRLCLLVAIASPGAIEGPDGARTRHLVRDGRRGQWGSSWKAAQTIAPLERPAVPKSDGEPAPVSASTPMSWMSYLASSLLGPSNAGYHDGDEDLEDADGEHGDDVGPEEAWRDVKVEMVECEVPVKVWPGNTAFKATEVVFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBT6</accession>
    <name>A0A2G8SBT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBT6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBT6"/>
    <dbReference type="OrthoDB" id="2748421at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="532" mass="60127" checksum="FEC2FC1E3F89FFDA" modified="2018-01-31" version="1">MSTSDKQPCAGDRRSSDYGQLISNLPPELFVQVLDWVYRLLRRIGITWDTNWTVPYQLVCRRWRDVVCSTPQFWQEITINSSPKWLDFCLTRCAGAPAIVDVFHPTCPEAIFTTLARHASIIRAFRVHCDVACLYDLEGLPSLLATPMPALEVLLLHGPYYESEILDVPLTHDLVPRLTSLELWNCIAPRDVAVYTPLRYLTFLGTKWAGSYDEFLDVLCNCQALEYLRLDEELLDSFAEKLASPPIDTRRRTTPPNLDLPHVKTVELSGQRGALFHLLATIHMPQATAVELTNCDDDDESGPLITRLLAPNPQLRIPFFSSLRTVSLSCWDGDPFNVSLHGGPDGNARFSVDYGMVHNELWPGNSYLEHNLVALMNIFSVASVHTLEVQGRLDEVAVETWHRVFQTFSSLRTLRVKGRGTLDTLWLGLSRGTVSSLEHDGAVCCPSLSEICVDDLPWVALRFKFAATAQLLETVRGVLSARVRAGCMRVKKLQLYLEYTDELWDQTCELREGFVEDVKALVGELDYRDRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC13</accession>
    <name>A0A2G8SC13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC13"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC13"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="575" mass="62796" checksum="A690467A4A7A07C9" modified="2018-01-31" version="1">MRRCLNCVVIVKNICEQAYEGGYNPDCRSTVATLSATCRAIHRVASKVLWSRLFSLRPLLKCMPPDVWVEEAQDATGDRSAIIALRRPPDTLDWDRFAANALLVTSFKRFGFDPDLEDDTYRTLCLYRPGPGPLLPNLRELAWEEANADAFEYGYQFLGPKLATLHIGQPPCDSLLLPMLRSLHTKCPQIRHLSVQCRSSVGPTDPVVSKAVQRLRHLETIDLSLPLLDDALVHLATLPSLSVAKIFLPRNSEVHERLAAVNAPVFPCLSVLHVNTIRLEPSLTCLIDMLSSTQLSEVRLSAAHDPSSVSLHSFLTALSRSPSRDALSTVSLSFPLPSTIPLMRSLHAVPPLAHPECALGLATLEPLFACPELAELDVTSFFLRPDDAFLAALAAACPRLQSLSLVPPYYAGHLPAATLAGLLPLLRRCPELEHLALPLDASTAPSITITAGDGEVGDSESQLRTLDVGDSPIRFADEVAALLSAHCTHPAFEIVVAEPDEGAGAPEHVRARELHGAVWEQVGRLVRLFVRVRSEERERCRRMGFRVGDSDGRVPPSSSGISAGDDDDSDDEHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCU3</accession>
    <name>A0A2G8SCU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_06297</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCU3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCU3"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013755418" description="mannan endo-1,4-beta-mannosidase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="46"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL31595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="448" mass="50020" checksum="7D2CD1E1C8E78173" modified="2018-01-31" version="1">MRPVLLVGALSLWTASLSCGAASSPSTTRQVLPGFVTTNGRQFELDGQPFVFIGANSYWLPLLTSQADVDATFQSMKEAGVKVLRTWGFNAINETELEGALETSLTYYQVWNSSQWILNEGPQGLQRLDNVIASAATHDIKVIVAFTNNWVGYGGSDLYVNWIAGAGQPHDVFFTDRRIIASYQSYVETIVERYKNSSAIFAWELMNEARCLSDTLPAGPACVPGSNTLRTWYEQQSNFVRSLDPNHLITTGGEGHFFWKHPLKYWFNHTLVAYGSVTRLPLIVERAAGEDFNRDMLLPNIDFGTYASPLSPILVCLVGLPMMFVLSYFRYDRYSELDYPGSNFTIEQWGLEWIDQHIHAANKANKPVILEEFGVGGLQNKTTIYPTIMPWQWGQLGLTEDGGNRVIKYADAIVDGASPNDGNTFYPNQTNVWDVFTRAAKIQNGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD41</accession>
    <name>A0A2G8SD41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD41"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD41"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="153"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="532" mass="59661" checksum="32A223F3FEB990AC" modified="2018-01-31" version="1">MSTHSAPPTIRGSTALHWIVVPKPGVVLSATKSSSSKQEQRSRPGSVLSPIPGPFLATVQVAQGSPSSSPCPQPLPLAPLSPLAPPLPAMSDYDSTNGDASISLPPRDNGSSVSPQPVPEQQHGLSPIIRKKLMGFVGFANLPNQVHRKSVRKGFQFTAMVVGESGLGKSTLINTLFNTTLYPPKVPIPPSAERPSTVAIESISADIEENGVRLRLTVVDTPGFGDFVNNDECWKPIVENIEARFDSYLEQENRVNRQKIVDNRVHACLYFIQPTGHSLKPIDIEFMRQLHTRVNLIPIIAKADTLTDEEVAEFKARVLSDIAHHKIQIFEAPTYENEDEEAVAEAKEIASKIPFAVVGSDRIVKTPDGREVRGRAYPWGVVEVDNEDHCDFVKLRQMLVRTYMEELREFTNDVLYENWRTEKLISMGVVQDSTVFKEVNPAIRIQEERIMHEAKLAKMETEMKLVFQQKVQEKEAKLKQSEEELYARHREMKEALEKQRLDLEDKKRRIESGRPLTPEKSSTGRKKNFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDU6</accession>
    <name>A0A2G8SDU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDU6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDU6"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="403" mass="43462" checksum="E2AB478DF6764CCC" modified="2018-01-31" version="1">MPSRHHSAIHLGGKRAIGIFAVCLVAFVVETQLAQYVQAQLDFQRPYLIFYVVHSSFAISFPLHVIYLSATSQHSIASILKTVLIAVQKHLSPKATSTLNATTFPTRRFLWLIFYLTTGLTVPSILWFVAIALAPVTDVTALWNTNALFAYVFTVYLFGHKWDARRLLAVLIATAGAAVVVYGDSGSNKKSSEFLDSSAIEQGPRPPLIGDLLTLVASLLYAAYQVAYKAYAALPNDPEVAADDMYTPLAATPDEPTDDLDAGPDAAIWSHAHIIDPLPFGLHPNLLTLGIGTCTLLVFWVPIPILHIIGIEPFELPHRGITYAAIGGIALSGAIFNAGFMVLLGVWGPVVTSVGSLLTIVLVFLSDAIWGGAVDMVTIWSVLGCTSIIVAFAILAYDMMKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE37</accession>
    <name>A0A2G8SE37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="17">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSI_06736</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 17">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="17"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE37"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE37"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 17" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="10 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013788958" description="NADH-cytochrome b5 reductase" evidence="19">
        <location>
            <begin position="30"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="101"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PIL32032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="38217" checksum="5787A604B8B419D2" modified="2018-01-31" version="1">MPNRYQVAFAASFVGTLFLLVLLTELVKAKLHQRGIYVSDLILLGTGKRPNRQPLPPSDAMSDLFDGSYTQLVALSLALLTSVFLAVKFGGGKRKPVLDPQTWKEFPLKEKIVISSNTAIYRFALPRSDDVLGLPIGQHVSVSAEINGKDIMRSYTPTSSDDDLGHFDLLIKAYEKGNISRYISLLKIGDKVRIKGPKGQFKYHSSLSREIGMIAGGTGITPMLQIIRAALKNPLDRTKLSLIYANVNHDDILLKKELDELASKHSHRFHVYYVLNNPPPNWAGGVGFVSKEQIEKYLPSTDNDIKVLLCGPPPMLTAMKKHLADLNYPAPRTVSKLEDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE72</accession>
    <name>A0A2G8SE72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE72"/>
    <dbReference type="OrthoDB" id="2804448at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="102" mass="11863" checksum="D8DB1FA5F35D1A2E" modified="2018-01-31" version="1">MANADELYALQEENLRMRSQIENVQARLVDLRGAHGDPSNMEHLDERLGELSEEASRKDAEYTKSREKLSKKIETMREKYREQKAIGTKLQEVSVFVVRLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE79</accession>
    <name>A0A2G8SE79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSI_06592</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE79"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE79"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="175"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="273"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="449"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="346"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="471"/>
            <end position="475"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PIL31888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="518" mass="55553" checksum="58F0273E64F16E9A" modified="2018-01-31" version="1">MTSLPVEAIRSLAEQHPKPSSVQFQYGTAGFRTLGNALDPVMFRVGILAALRSKKLDGKTIGVMVTASHNPEPDNGVKLVDPRGEMLEASWETHATNLANAPTTNALIEAVEALHGFKALGAEARNAGVTTTPVLHYLVRAINTKGTKGSYGEDTEEGYLEKLSSSFKKLVAGKPALPSLVIDCANGVGAVVGEKLAHQLGNSLSMILTNTAIDTLGALNNACGADFVKTQQKLPPSLASVLKPGQRACSLDGDADRLMYYYLDDQGHFHMLDGDKIATLVAAFIVELTKSAGLEGKVQVGIVQTAYANGGSTKYLSERLPVKCVPTGVKHLHHAAEHYDIGVYFEANGHGTVLFSPETLETLSTHQPSTPAQSTALNHLVNLTNVINQTVGDALSDMLLVETILAHKSYSGLEWDSLYVDLPNRLVKVVVADRGAFKTEDAERRLISPPGLQAKLDELVRRYEGGRSFVRPSGTEDVVRVYAEAIARSQADELAFRVAGLVYDEVGGDPAKRPSEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFB6</accession>
    <name>A0A2G8SFB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFB6"/>
    <dbReference type="OrthoDB" id="2755487at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="101"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="764" mass="85475" checksum="1EFDB13A067B56FD" modified="2018-01-31" version="1">MRSAKNLTEEDISELLVTAINGNELTPGSTCSRYTPCFEPTIDKTSYDDSTAIFDTAHIPSKGHPRWPDLSVPVEVYTHRHAIDPFDYTDSQDLDANERLRHRILEHISTVADLLFAAQRDRVFLFMILIIGRRFRFLRLDRAGIITTPSIDCYEDPHVLCDILWRVSQLNDIALGFDPTATRVLPGDVNFSRMDFLAISNPSDLDDTERVQVRDGKTTRNYLIGKPSFRSGEFLGRGTCGYVAYDCKRHSFVWFKDAWRASYMLAETEGDVLRRLNSAGVSNVPTLVCDGDVGGQSTITADWWEQMHPETSTPVRPPPSLASSSSSATLASSASPGSRKRKRGDATSTSRRSRWSPGVTMHSGCPLRQHKHYRVVVEEVCMPLKSFQYGRQLVSVVLDCLRAHYQAAIYPKTRLLHCDISGGNILICPKIRRDKNGENPMVELSKPVDTQDTASRATQADRMGTYEFMSVNLLNHIAQPVKISDELESFFHVLVYYAVRHLRSNCTGVTSWIDNYFHRYSCPERMLTCGQKSYAIEVTGRLQIRSPDRPLVFDSPLEDVLATILESLHAHYKVAQYDLAKARPPPPPSPPPPLRPSLLPLLPLPPSPSSPSSPPPPPLSVPRLLPLDFDDVDDAQLAQWEAELEAGPLDNSPTAEDRALARNVAGHRFVLDLLLRTLRDPRWCADDRIPSVPDPQCGVSPATSLKPRSGDEPSELARRQEPPSNKRQRTSGPESKRNASLPVPVPARLRAQVVGRLRYLDHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFG1</accession>
    <name>A0A2G8SFG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_05218</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFG1"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013423714" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL32515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="607" mass="66119" checksum="2F44F579A7F1C1AF" modified="2018-01-31" version="1">MQLSARFVRSVYAAVILASAASAVPFPDSLKHTTLQVRTIGAHKTVESFHPESLFQTFGIDGIDHPLSARAEFSLEEAAVSFVQSKLNVTPNAAAYRTGYSNDVAQHAYIHQQINGIPIANAVANVAFNKANKVVSFGSSFVNVPSNAPSTIPSISAADAISKAENELGGTYNQYPTKLEYVAKQDGSVALTHVVQVRDDSKAMWYQAFVDAHTGDIVQLTDFVSHASYRVLPITKQNVLQGFETLNDPQNLASSPYGWHSSDGVTNTTDTSGNNVIAFVASADGSFWSTTGQSSFTLNFVYYQDPTQAPDALQANIDAARVNTFYVANSMHDIAYQYGFTEAAYNFQDYNFGKGGAEGDRVELSVQDVSSANNSFFATPADGQSGYMRMGIWYYASPARDSSLANDLVVHEYTHGITNRMTGGGTGDCLQTLEAEGLGEGWSDAFAEWTHWQWPTNTFTDWIMAAYVYDDLAGLRNYPYSTNTTTNPLRYSDLQTLNEQHDIGEVWANVLHNVYAQLVAAHGYSATARTDPTTTGGNVVYLHLFLDALAIQPCNPTFPQARDAWIQADAIRYNGANYCLLWNVFASRGLGVNAASHIDDTTVPSEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG80</accession>
    <name>A0A2G8SG80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG80"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="102" mass="10347" checksum="2766136E267F8891" modified="2018-01-31" version="1">MDFKAEIEKLARALPAATSPPTTKLPPPRNTARARERERGTGPTHAGVSATRQAAAFSPGSLAGPLPASPRPCPSSLSGSAPGVAVQELRLLCEAGLPAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGJ2</accession>
    <name>A0A2G8SGJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGJ2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="45751" checksum="983F3B37C7464B1A" modified="2018-01-31" version="1">MRSKPPAFEFSLEADRRARQTYSVFDSLPPLARALTTTPSATPATTRRISEPQSPMRQPPRQATAAPAPALLHSGGSEPSRAFSPAPLAHFFRRFHEPGKGPPGMSSLRSREGRESANTRTREMGNAPHRAAAAPRTGPAPRMRLRVHMAYACYCVHTLPAQTDAFVASRPPARQAPIALRRAARALALVRERFLGVDPNRRARIHTYGCPDARSQPQTQAQAQMHARGQEGARGDGSNLKFKGVDANADADAPAPRLDSVLGSAVPVSTSRGCCCSSLAGSLADWRARTRDDVSADLPQRLPKLDALRVAVAQMGGSRARRGSFPELYLRVMARSGRAGGRGQGPISGWGLLRLRGRSRNPWGVASWFETSKTGGGAGYYAFDAPRSECNMATYVRAYGTPSPPGSAGGSVSWRPLLALSSSPGGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHG3</accession>
    <name>A0A2G8SHG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_04665</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHG3"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013694843" description="beta-glucosidase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="18">
        <location>
            <begin position="111"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="17">
        <location>
            <begin position="274"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="19">
        <location>
            <begin position="675"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="447"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL33215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="889" mass="97910" checksum="64D2C997C3801FF3" modified="2018-01-31" version="1">MSPRAALKFALLAQLASLASATNTDPKVLDACPGYQAKNVFNYGHNLTADLVLGGTACNVFGNDTEKLKLEVTYENKDRIHVKITDPATNRYEVPEEVLSRPKADLSAGPQTSNILFNYTASPFSFSVYRAKTHEVLFSTASHPIIFEPQYLRVKTNLPANANIYGLGEHSDSFRLPTHNYTRTMWSRDAYGLPKGQNLYGNHPIYFEHRTTGTHGVFLLNSNGMDIKLDDTEGTGTTLEYNVIGGVLDFYFLAGSESDPTELVRQYADVVGTPAEVPYWSFGFHQCRFGYTNYIDVSEVITNYSAAGIPLETMWTDIDYMDRRRVFTVDPQYFPLKRVREIVDYLHARHQKYILMTDPAIAYAPGEGYGAFDRGTAADVWLKAANGSSPFLGAVWPGVTVFPDWFHPKAQAFWNNEFKLFYNPESGVDIDGVELLQLPVHGPVRAGEAAEAPAPRTSSPPDPNTPIFGEAPPSVRKRASAPDHSKDNVQSPPYAIANHAGSGALSDRTAYTDARHANGLIEYDTHNLYGHMMSTTTQGSMAARRPGLKTLVITRSTFPGAGAKVGKWLGDNLSTWSEYKSSIAGILGMAGIYQIPMVGADICGFGGSTNENMCARWAMLGAFYPFMRNHADLSSISQEFYRWPTTAQAARNALDTRYRLLDYLYTAFHHAKKDGSPVLRPLWYAFPKDNNTFAIDSQFFFGPSVLVSPVIDANSTSVNVYYPHELFYDFHTLAPTTGGSSVHLTNVNFTSIPASIMGGAVLPLRVQGQNTTTALRKTDFELVVAPSLADGHAHGSLYLDDGVSVAPLNHTSVSFTYEKGRLDVHGWYGYATGVNVSRVRFANTKSTPKTVTLNNKTVAADKIAFDSSTGVLDVKLDIPFKSNFVVEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHJ9</accession>
    <name>A0A2G8SHJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHJ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHJ9"/>
    <dbReference type="OrthoDB" id="3256408at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="730" mass="78372" checksum="F77956E692DE1775" modified="2018-01-31" version="1">MSTCRARFSPSNSRVSPSSLRPSLSPPSPTDTTTPPWRPPPHPCNVAYPPIPGSLQLDNLGPADLRAKSTPPGDQHRPPRPVYPSPPLTDAALASTIPLPDVPGEPLHKQECPQFREGVVDGNMSHDGAQHFTPLSPPPTVFVGPSELPEGEPFQDGGHQVESWSYGEDPQDGGVCAPLFPPVRDDSGFEEFGTQGGCGADPRFEGSQENRSLIEPTSIWIPHSPLSMDEILPLGDLSSLHGVAPALHGGDQSSGHSNGLVSPISPSGTGSNTDSWSSGSVMDWTYSPSSTLVNTLSLPPSPKPSGLSLELPELDTSLGFQPHHALPLQQPSPLSPVELPFGQSGPHWFPGDTLGAPLGKTSPSNEHAPLPEDHDPFFPFTHSSLLRPPSADLDSEYPDSIMPSEDDESPPSSPRRRPLNDLHDTTPPHGDILLTPIPRSPHLPLADLDMDDPAEAPCSPHSPHALLPELDGEDEQQYPPITTIAPSLLGGAPEPQPQHAGLGLFLQSDPPLARSPSPDDDDFGFLDIQLDPESANVEVDEFLALRAMRKNALAQERAARMAETELSERITVAASALLPPSHADADSMDVDAEPVVLDVAEKRVRKRELHALMDMRTEARRTRKLQKQRSKEIGALLDFKMHSPMSPMEGLPPLVIGGGGKGWTKTIAHLVAHMVLRRHDRSRPLENKPPAPQIRSPTSLRRSLSAEDLSLLSSMGVAGGDEDGDDDMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHT0</accession>
    <name>A0A2G8SHT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHT0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="12937" checksum="25B68DADCA42B618" modified="2018-01-31" version="1">MSRSFASPMLGMLERLRPVEHPDKFIKSLPLDADARIFGPPSLGKTSCDAMAVACNMLPVLILGDTLGMPSEPPNAFKAAQSLCGTGLLTAQQNNRRDAIWPKIGGITMGATTDGHLRECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI62</accession>
    <name>A0A2G8SI62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI62"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013600731" description="Transporter" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="54" mass="5506" checksum="623E0D625FFA90F5" modified="2018-01-31" version="1">MQTPFNVLAFLLLATSALVGAIDPRQARVLAVNRNAACSGPSGCAPSNDAAHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI79</accession>
    <name>A0A2G8SI79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_04084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI79"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI79"/>
    <dbReference type="OrthoDB" id="5788137at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="130"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="218"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="314" mass="35112" checksum="6FA2649A23A529A1" modified="2018-01-31" version="1">MVELKTLQALYDSTREWFVVLPPFFCPATFVIDAPFGRFATAKASIFTVDGIRSWICMELVSLILFVNAYLRSPLSPTTTLALTSPTGLLPNAPPLSPTHPSTLLAAAYITHYLNRALVSPLRTPSRSKSHLLVVSSAVFFNVVNGSLMGAYLSSPSAQTFLHDAFARPSFWLGLGLWALGFAGNIVHDEILLNIRRNAKKPSPSKNDRDDDDANNGKNKQEHYAIPHGLLYRLISYPNYFCEWAEWLGFALAASPPPSVASVGAFVATVTPPWLFFFNEIWLMLPRAYKGHRWYLARFPDYPKERKAVIPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIM7</accession>
    <name>A0A2G8SIM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIM7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIM7"/>
    <dbReference type="OrthoDB" id="2736048at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="153" mass="16642" checksum="93557FED65B6155C" modified="2018-01-31" version="1">MPIRVPCPGAKCNLPPFVLCPKAELRNLRGLYFSSAVDEASAVNIATVIPRAESRLAKRFPSIESVLGTGTPIHECLVTVSDDQGKPYRFFVAFREQQNLPINPALKKLLPDGDFRGEVVVMRAGARVMVVDLRGAKLALLAKRAVRASSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKK6</accession>
    <name>A0A2G8SKK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SKK6"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="981"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="1142"/>
            <end position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1426" mass="158313" checksum="7A06343E7BFBBEEB" modified="2018-01-31" version="1">MSGIAKTKLKGARDAIAKKDYEKARDAAQQALEYDPDNYLANVFLGVAYRNLKDYQQSEQVYRKAIDSDGQQLLAWQGLSQLYEETRNWDEYLKILNKLAELYAAGNEATKCAETVQKIIDIRRNADLSAPIELAEALTLLLPESPFYATLSLLPPPDPTSPTSTTTFVAQSAIHNSLPVLEELVSIYEKHEQGVRRDEVSKRRTRLNGPPLEQIQRDVALEILSISQLPRLYNEVLNHPNTSDELRRETEAKLLHLKQQHLFALPPSGKTTEKVRLASELDELISGMVLLKIPNELAWTLLIESKDAAEIEDYDFNLLRQFIGLFPRSPLMKLVRAYFEYMSVPLSEDEDEDVPTPLAEDEADYIDIMMDAFSSLGDSILAHRIIGGLYQQEADYENTIKVSESGLELVRRVEQNWGRPINQTKKAFNIMLSSSLVHYFPPKHHLRAQRVIDGLLSEDPDNIPALMSRGFILEHAKKWPEAGAVFAKVVQLDSEGVDHGLRAKEERAWSEAMCKKLQAAADELRDVISVLDELEGREEDKARAWWRLGRSHWTMGPEHCEEAYKYFVTALKRSSTFAPAFTSLGIYYSEFVSPPDPNRASKCFQKAFELDPREAEAARRLAEGFAEEGEWDLVEVVARRTIDGEGGLEQGPDAKASSRYLPLNAWAWKAVGAVELTRRNYVPAIEALQIALRTDANDHMSWLRLGEAYSKAGRYAAAFKALERARELDPDDWVASYFIGDAQRQMGVYAEAISAFETILVGRPAELGVLHSLGQTYLELGHFELATGFLARAETSFISAIRVTLVLLDASSGFRRVAWKTLADSFYQLSNLSGFSDQESVKEVAASVLPLVTEHPGKDLVDIISEPLSIDDQTDMALFMLQIAFAAYEYRLSLGAIDDVAKATAHYDLGAALSAFARRTLDAVKREKAQQEAITQFKHALRLEPGNDAFWIALGNVTFLSQPTLCQHAYIRAIEIDGKNAATWTNLGMFYLHHEDIELANEAFYKAQTLDPDYALAWVGQALVATANNHNREASALFEHATGLTAAAPEADLEYATRLFNKVNETTKSRSVSSEALLPAFFVLDRCCKQRPKDTTALHLFGLVCERVGHVELGIEMISRAISVLEAAYEEAEDPIVERQFTTAHANMARLRMATEDYEGALESYQVATGLLPEDPEEGDTDTKALLAQCQFGSGLVNFKLGQLPEALGLFESAIATAADHPTIRGHIVVLLAQTLWAIGTDEAKESAKAQLLQSIEYDPENLMAINTLAGMGILTDDDGLVDAALSELLSLPLDQRHERDPEREVAYLLVQHHLGQGDAKQALSVAQRAVFAEPERTDARRELVSLTLQSGESAVALAVLGGSAETRGSFAELRASLALHAVSLCLESGTVAEALKLAQKGVMLSPWDQRGWETLAYVQSRPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKN9</accession>
    <name>A0A2G8SKN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKN9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="167" mass="18825" checksum="A5CEBD7DAFE16BBB" modified="2018-01-31" version="1">MPAYILPSTADVFLTCTTQTEPPVFTPCMAENVDCLRYSIRVRNAGADLTIPLPLSRLQPTDGPLIRLLLAFLHSRAFHRFRVSSTAHITIQTILGALWAFWSDIHGIKPTAYKEFCERLRALMPLTEPEAEDMTDRLQDFIAWVEVKVGVTELKFKTLFSNSTAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKP8</accession>
    <name>A0A2G8SKP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKP8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKP8"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654730" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="253" mass="27758" checksum="2FF38B1E0545013F" modified="2018-01-31" version="1">MRPFFLAAFIPLATAKTLIVDFSTFASSGLTVAQFLDQHSLYRSAYQINTNYPTEPTADPYPHIFKAENVDIQDGYLTLKVSGGTLQGSAVPSAEIATYDKNILYGTFKTVAIASPVPGVCHGFFTYKNDCEESDIELLTSFFNTGNAYVQPGLQLTNQNLQCDHSQNTHTQVAYPADPTAGEHEYTLVWSANSVQYLFDGKVVSTLTTNVPNQPSSFIWNSWSGGNVRWTAGPPAQDSILRIKSISLDYQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL52</accession>
    <name>A0A2G8SL52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL52"/>
    <dbReference type="STRING" id="1077348.A0A2G8SL52"/>
    <dbReference type="OrthoDB" id="3235294at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="147" mass="16686" checksum="748BB619C8121D42" modified="2018-01-31" version="1">MYPDDNSTKLIELQAAGRCPGGERHVLLRWTNGENGETKYTQLIHLTGGRGNYAFHTPQVKPHSEASRRYNTFYPLGYYTRAQRDQVIALAQSIKFNRHSDVNDCCVWMRDLLGAMVAYGPLRKDIFDRVVAEVPLRSRVPESDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLC3</accession>
    <name>A0A2G8SLC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLC3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLC3"/>
    <dbReference type="OrthoDB" id="2754195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="78248" checksum="2E4AFA6AA8B23502" modified="2018-01-31" version="1">MKQYLSLFASPPDYPDTPIFPLTFFSRCIAAYVSPLDLIHLSHTSRQLCRLFMSKTSRTTWKTVLGNVPELPPCPGDMCEPLYAALVFGKYCFGCGVEDAFWVDYALRLRVCETCYKANVVEGTEVLKSLPQDTRHIINDVLFMLVPSANIFNFANLDVSFDRINPLYHLQEDFYFKPELEAMLRLLWPVPASKSDVSELKELTRIRANYVMMRQMHAVLIHAWDNLCATSASESDFSRIKSMYRSVEDIQVFGCDWDEVCAPENPVFAGYLSGKGAEENAIVRLRRDPPKPHAQLAAERDTLSQQEVTGRQARLRARRAQVEKWYQTVVVQHPYLACRRAELPNAHDTEGLWESLVSGSDGNARDTFDPDAPLDGPFVRMFIVTPLIMYQRRLVRCLAAELEEYERRHVEDAGASSLTSRAWELSAGAEHEPWTMEWQVDPLEMLVRPTALFACRECGAQPYAFPAINEHWQEAHPDESAWVRVGTGFGGAGEYGAEVWEGAEVAERILEVLVRKGLREGERNMGGLNELVEEGWVYCACGDPTMATPDQVEEDLGWETLVDHVLNHLNDNMLRRKTSPNGSNGAPVWLDDHNLASCIKYLPEDADTFEGNNRVTADDSTRKRVDALLRKCPETSSPACLLCVLTPDSRKDDSLFLMANADAIVYHMEAKHGKHFEDADVVFWDKAVFDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLJ1</accession>
    <name>A0A2G8SLJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_03398</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLJ1"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="698"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="806"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="830"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="479"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="776"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="159"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL34619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="98726" checksum="7F3D260E225B38B3" modified="2018-01-31" version="1">MASPSNATGPDQAAQPDTRPPGGTRRSGTKTPRRVQWMSDERNPSPSPRALDEHGLDPAAFETLTHALERHRSTSTSAEGERPTNPLSSRVMTAVSPGPSLPSSPSPEITPIREVPGEAFIEKSETAGLPGRDIEEYSHAQAQKLITAHKYNLFKFRGKHRHRRSGSEALSDADHEGKKPRRGLFKGRDAWSDIEKSAETRTETKASEPKGILSTLLSFYEPASVLQSGMSTPARSEMSFDESRAASIYNAQSSPTLPPPASVRGEGYFPPQANANGSVLSLRPPNHPWTRVPFSNSRPPKSRGGAGVFGPLIAGTNNITGVAAPMSATVAPDLKRPGYHLSRYSLDESKLPKAGSAVERKPLTRSRSMHFDSQSLRSPLMTGPPTPASEETLSPHSSSGGSQSPVAPLAGKQGWNGVLKDLPKFAGRTPSTVPSTPATELGAEDGASSFDEKREKRRKRRKAEIWITRHVAEIVCRQEFILKLARAMMMFGGPTHRLQAQIKATAKVLDIELSCMYLPDVMLVSFDDAGTGTSNIKFIRQGSALDIGKLQEAHELYWEVIHDNVSVKDASVHLDDLMRRKQFYKNWQIVLFGGACSASICSVSFNGSFIDCLVSFPLGCLLILIQFFAARNELYSNVFEITVATVFSFIAAALSATPYFCYSAVASSSVVLILPGFIVLCGSLELSSRNIVSGAVRVCFACIYSLFLGFGLAIGATAFSKLTNHSLAGSNDLTCGLSHDPHGPWWQRTPSLWWAFLTVPLYSLFLSLRNHAPWNRRELYLLIAISCIGWVTNHFTGTRFHNQSDISAAVGALAVGFVANIYGRFFNGSAFVVMITGILFQLPSGLANGGLFTFVQQQESGSSTNESYLSGFQTALQLISVCIGLTVGLGISLVLVHPIPSRRRAAGLFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPG9</accession>
    <name>A0A2G8SPG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_02341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPG9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPG9"/>
    <dbReference type="OrthoDB" id="2747507at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="51"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="633" mass="71033" checksum="35184542201C401C" modified="2018-01-31" version="1">MPPRSPDDSESIQIARDFMSDYDSNLLAISAVAAREEIQINDDKRVTSRTCTYCKQESQVNLQSCPRCKAARYCNEECQRTDYKDNHRRECTEFVHPPRTRAFRTHLIGDETWPHSPIFAHAHEDGIGCWISTGNKVDCEMGQLSRRLIPDIKQSDPRYAARVERMLNEPKKLIPAAKQNLTTLHVLVQNRRKDNVPVLLFGGLAQVVTKASGTKDALRGRMPDDDITTFTRNGKKHVAIGVARDPWDNELRVHVAHVNGDAVDLPPYPSVVEDASQAIVALSRGDYAVMSLQFRTGDGKNINRDWQAFRLLDHVVIPFMVWNSNLPAAALAAILPSAYKLSATSTPPSLESDVKRLRLAFDQGAITRFYKDAIARGDSEFLRTHHGDIHAAMNISMNKATMVLTEHTLWLAELPEFQRPAGWRASMKNSIKLAAVGVPDDPVYLRPRLYVSHINGQALHKPPHPPGMLDVEDGIVALDPGDFAIIRIQFRVGDEYTVNMEWQALRCLDHIIIPFMPWDRLSHPISLSLAVPPAYMLPELTAWAARAPIVKHLLVPFDQDAITVHYRDYIEHGEEAFFRSHYGKAHMDLTCTAAKSSAALAAMDLLNGGFTPEEIESSKQLGEFLAKFFRGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQF5</accession>
    <name>A0A2G8SQF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQF5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQF5"/>
    <dbReference type="OrthoDB" id="2732257at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="362"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="676" mass="79031" checksum="97E5D7F89DC046EA" modified="2018-01-31" version="1">MNQEPEKRIHPYVNDKMFYKNLEGGYVNTEYFWRDHQPWLQEQGYMLRPRYHPDWKPSWEGTKKDFEDVEDGLIPMRLEVMDATRIADGRVVVLKKVNKNTHPYEAEIGRLFSTELLASDPHNRCVPIYDVLQSPLDDSKVFLVMPYLMRHHEGLEFIHGQHVAHRDVMALNVMMDPAPLYSDTPHPIKRGKSYDFKRRVRRFTRTERPVRYYYIDFGLSCRYGPDDASPLEDIIVGGDKSVPEFEGTDEPQNPFWTDIYYLGNLIRTGFLETARGLEFMQPLIDDMVQNEPSKRPTINQARSRFEELRGSLSEHVEVFRGGLFEGEFLWRNHQLWLAESGYMLRPRYRLDWEPSWLKSKKHPLLCEDGRAPLVTTVMDAVRTTDGRIVALKQVPKSRYPDEEELNRFLTMSEPQASDHHNHSIPVYEILQSPLDDNVLFMVMPYLIRINRVKFATVGEAVECFRQLFEGLQFLHQHHIAHCDIHINNIMMDPTVFSDIPHPTYRSRSIDFKHSLNTRTRTSHPPRYYYIDFGLSWRLPPEDPSPRIVVSFPGDKTIPEIRDPGAGGLHDPYKIDVYCLGNIIREHFMAKSRSFDFLQPVVDEMVQGDPAKRPSIDVAFQHFEQLRASLSPWTLRSRVVYEDELPLGRLFRACRHALRTAFWIARGTPALPTPRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQH1</accession>
    <name>A0A2G8SQH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01674</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQH1"/>
    <dbReference type="OrthoDB" id="10614764at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013909946" description="Transporter" evidence="3">
        <location>
            <begin position="24"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="64998" checksum="17C25B3C4A41B998" modified="2018-01-31" version="1">MSSTTQFVTSSIIVLALLQLVSSGSLSSIFVQLCILISLGFLMIGLTRSTFNPLLSVLASALPFSLSQIRAPSLDPFHGIATIIAFASAVIRSLYSVTIIVLLWALSHSIVLFLHTSAYVALVLFPPEPSRCCKCTTKHEHEEAPTVVKVEYCRSRDTDAVFIDASRRLDEFCGSRTGSFGASDVSTCTDETDAASSSTRDSVDSSFGDPDSSSNSTWHSDATSVTLLSDSDICSIAARFNHALVRKRFYVEGSVFCTPAPGRHYELATETGTAESLSSNQATESGLDMAGLLSPSFSSTSISAQSPAPSNMALDFSSSCSLFGMSPSPTHASSNLSSVFSTSFIAVARATSSSRSAPISRRSSFSSIAQLFRPLSLLASSTSSDVSLASTSPSPSRPLSMYRPLMLLPSADHSSTSSSSSLADFFFDAPELTGESPSPPFSPSVSGYSCADVPTPAPWIPASLSAWYLAEGRSVADNSLSHPLRIFGIPADELEAHSYSLYSDDFSAKDEAYLCAALGLYEPSISVPRCGFFRASGDPLRSHPSCREWYGWVFPGRGGHKPTFVPEEIPAQAPYDEHELAYLWARWGFWPTYAPRPEYMSGYACGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQJ7</accession>
    <name>A0A2G8SQJ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_01508</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQJ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQJ7"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL35848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="270" mass="29702" checksum="FF400957B31D8906" modified="2018-01-31" version="1">MAKIEEIQEPPPQAAQAKKRKGPPALVKYYLVLYNVLSTAGWAYILLITANAVFNLDGTHATVPPAPGAATVQRQVEAALPAVLVPAIRRAARAYAAVGAQTAFVQSFAALEVLHVLLGWVRSPLGTTLIQVGSRLYLVWGITHLFPQETHTNPLYASMVLSWSLTEVVRYSFYAFSLLGTEPAPLVFLRYTLFYILYPTGASSEAFLMYATLPQPVLSLGLQGGLHALVRKVLFVTWWPGLYVMYTHMMKQRRKVFGGGRSANPKVKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR69</accession>
    <name>A0A2G8SR69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR69"/>
    <dbReference type="OrthoDB" id="3242031at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="61"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="183" mass="20390" checksum="F5786DEC4B21435C" modified="2018-01-31" version="1">MSNFGLPFFLEDTTGKLTGSEFVDLHNRMHLSLKQTLRDAHHSAYVIYDLSRRSATRGGLLVPLATLDFGSQNALGSIKIGDHDHIPMGHYLMKSAGSAVKSRKFKAADGQEYRWTLQTDGEWQCTNAKNNYHVATYSQKPAGEPQYPSSSGCMLTVEEAYPHLVGELLASLIVMRHIEKHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRF5</accession>
    <name>A0A2G8SRF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01818</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRF5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRF5"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL36158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="394" mass="43562" checksum="5E225C48AAEEAD07" modified="2018-01-31" version="1">MMWPILTKVHYEALPTLLPTRHTLTHVLLSLLLNWVFAPFLMLALAWAALPDLPTYRTGVIMVGLARCIAMVMVWNALARGDGEYCAILVVLNSLLQIVLYAPLALLFVNVLGGGGGTEETLHVSYGDVAISVLIYLGIPLAAGIATRFAMLRLTSRRFFEEKFLPYFGPLALLGLLYTIVVMFAYQGHHIVHNLGPVFRVFVPLVLYFVIMWSAAFALVWWCARRAGRARDKENTSELEPRTEQDVEGGRVTRHSSFPEGARKAEWSYEMAVVQSFTAASNNFVSTFPWLCAGAACVLFVFPGACDSGHDRSLWSRVRPGPRRDYWTTRGGSCPTWSHMGRPLVASAVEMDVSYRGGGGEHGRHGDQATRSANGGHGVDWCGRGRIVGDECRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRI6</accession>
    <name>A0A2G8SRI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_00073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRI6"/>
    <dbReference type="OrthoDB" id="2721240at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013788963" description="chitinase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="44"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL36385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="319" mass="33261" checksum="722013610400BF86" modified="2018-01-31" version="1">MFSSTRMITAVFAAFALASTGFAAPAPADGDISALSARAVAPTSRFVIYSNNWVTGGAPPASALKGFNVFALSFLTLKGAVDQAGNWAALPAAQKTAKKNEYHNAGIKIIASAFGATDLPTTSGANAVSTANTMAQWVKTNGLDGIDVDYEDLTAMNKGDGAAEKWVSDFTTTLRKTLPQGQYILSHAPLAPWLAPHHQFAAGAYVKINQNVGSLIDWYNVQFYNQGMYADCAGLLTSSGGSFPGSSLFEIPQHGIPLNKLVIGKPATGADASNGFMSPAALGSCVKQAKAKGWNGGVMVWQFPHADASWMQAAKGGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRT2</accession>
    <name>A0A2G8SRT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRT2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="204" mass="22139" checksum="0EDE34B1C35800D4" modified="2018-01-31" version="1">MQTNLPPLLAPLHNDVIMGAPNTDPIAVLAAAAPDTVKLDDVDDPSFQSAPSAAKKAPPPVIPPVDVFNMLTDNSTHPSPDAAALVGAQDADWDLRRRQVCTMIAQSRIKRGHLALDMCRLQAMHKAATGAVELFPQERFDAYMGLVNRCIYDDDDKVTAEDVQYHLMGVLPQSVRDLITNSSPAGEEDEDEDDHDNEDGTQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRX6</accession>
    <name>A0A2G8SRX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRX6"/>
    <dbReference type="OrthoDB" id="2755983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="186" mass="21263" checksum="B9D5FAA5FDB15BDA" modified="2018-01-31" version="1">MTGCQSLGQTLRGQYARREMMIRSQLRQSINAELGCSTARMRWSLQKYLDEIFFGLGIRFAWVRYLLFANLSKHTGLARIMHITTLWNAGVIYFARVTPEERETTLHDLLSAAPGPLHLGLPEWYGRSDIKACRYRPITNPLGLPYKYERNGPKSAKTVSDEAEVAAEAEVREAKERMLEAQLEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS05</accession>
    <name>A0A2G8SS05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS05"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="16833" checksum="DE35A78D52587B59" modified="2018-01-31" version="1">MTMQVHLQYRKYDRPPSKFSRPPSNPAGNDTPTPSYPITRSHGVYGFPLNSCTVSSNSYYLTSSQQPSIDMQFKTLFALVSFAAVAFAAPADPADASADAEQLSLTTQFTTDTFTATRILQSMMTQAPFITTLTQTTVWTVEHTVTVAAPTAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSN3</accession>
    <name>A0A2G8SSN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_00454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSN3"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013429854" description="Peptide hydrolase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="183"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL36764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="433" mass="48083" checksum="D2BDDD8A2CCE7BEA" modified="2018-01-31" version="1">MKFLALLALVSAALATPALSLYDINAQEPLLGDVLPTSYPGFDLDLDAKRLVQLEGQEEPIVMTELEKIRAKAQGIRFFDVTDALDLGSRARFRVATKPSYPTPNNTAIVRSVIDTLEVQNLRDILDNLTSFRTRYYRSETGKRSQQWLLNKITELTTAYAPKFLQDSISIEEFSHSWQQSSIIVRIPGTSTDDDGVVIIGAHLDSTNNWPFLPAPGADDDGSGSTSILEAYRGLIAAGFQPERTVEFHWYSAEEGGLLGSQAVARSYESRNVNVVAMSQYDMTAWVKRGTKEEVGIITDYTDSDLTTFNKNLVEQYLSIPWVETKCGYACSDQYVLDDAAERPAVPPIPDIPSQSPSASWRKAGYPSVFTIEATFENSNHGHIHTSDEYANSDTLSHVKYDISDEFSFEHMLEFSKLAVGFAIELGGWKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSN9</accession>
    <name>A0A2G8SSN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSN9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSN9"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="441" mass="47707" checksum="C93E8D417D6A2BA4" modified="2018-01-31" version="1">MVNYGGDEVSALVLDFGSSSLRAGYAGDDTPKAIVPTSFGFIDDPAEANGGDVTMGDAGATEGEQPPAPPKPKVKLHIGQNGPSLWRSGMEVGNPMHDGLIQNFDCVPPLINHAFSEVMRCSPSDHPVLITEAPWNTPANRERMAEIMFEEFQVPAFYIANTGVLNAFAAGKGSALVIDVGQSTASVTPVVDGFVLRKGLAHCALPQLVHAHAKHLLTNPTQTRQGISLVPHQLIANRTPVDAGVPAKFTLREDRQAGTTESWRAWAENHEVEEWIQSVAGILTQGWNDQFASGQGARHYEFPTGYNNYFTGMERYAVGEQFFAHSSALVASNPNLPKTIPSLIVSSIQQCDNDLRQVLLGNVVLTGGGSLFAGFADRLSAEMSRHFQHVKIHAPGNPIERRYGGWLGGSILASLGTFHQLWISKEEWQEHGKAIVGQRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST16</accession>
    <name>A0A2G8ST16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST16"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST16"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="311" mass="33963" checksum="BCBF28E657292811" modified="2018-01-31" version="1">MANDPMLYVPATAHYSPPYAPATNVNQHLQHLGFPQLRLAQGANPNPHDPNNHNPLAPPGVPGAEIRAIPVRALMIPLMMLVFRTLLLLYFFSPSKRPLFGLLLSVWILYEAWNAMRLVLNDGNDREAGGAAGPGAANGAAGPGEPAAPAGAGAGPNGNGTANGATDRSPAGAVLDRLSTLNLAAEDAILDTDAPVPEPSLAQKTKMFCALFFMTLWPSAWDRRRNALRRREGRIRTDAHAREAVMRDREEALTANAGGDSQDGAQSPLRSEEDLARARQREQRVARHERRPLWLRQYVQRVEYTEWVDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STC9</accession>
    <name>A0A2G8STC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="11">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_00712</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STC9"/>
    <dbReference type="STRING" id="1077348.A0A2G8STC9"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="175"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="944"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL37020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="975" mass="110401" checksum="11E9CB0E4000B881" modified="2018-01-31" version="1">MSSAHSPERSPGPRSASNPRLFTPSPNGSHSDLSALTDQSRPPIILGICAMDIKARSKAMREILTRLVERSNGAIEVKVFGDKVILDEDVENWPRCDVLISFFSTDFPLDKAISYVKLRQPHCINDLPPQALLWDRRLVGAVLDHLSVPTPRRLEVSRDGGPKIDDELRDIMKQKIGISLGGFQVTPEVTLSEDGNAIIIDGQVMDKPFVEKPVSGEDHNVYIYFRGGGGRRLFRKVGNKSSELDPHLNFPRTDGSYIYEEFVDVDNSEDIKVYTVGRDYTHAETRKSPVVDGVVRRNTEGKEIRFITHLNDEEKDWARRISDGFGQMVCGFDMLRCDGGRRSQIIDVNGWSFVKGNDTYYDRTAEILASLCLHVAESPERPLPAAEATVEEPTWLLKANVTVFRHADRTPKQKLKFNFPIGERWTQPFVTLLNGEREEIILRERGQLNRIATAVEEAKGLGADGEDLVKLTQLNNALFSKIDLPGTKAQLKPVYSKKQPGQVRRLTKLTLVFKWGGEFTHSARYQSRDLGENMKKDISIMNKDILRNVKIYTSSERRVVASAEIFATALFDTSPSSAASSSLSANGGHQSGVHSSRSSIDGYASGSHYTPRRENSVPAQKPPKLIVRKDLLDDSNAAKDLMDDVKKRLKILLRPGEPEKRPELTWPKSMKKEPVEVVKEVIELLSTFRDIMRRNWETMDVDKIQERWCCGDEPWLFRERWEKLFEDFCDVKQEKFDPSRVSELYDTIKYCALHHRTFLFSIFNEDGRTEQAPHDRRLHELYGRAKALFDLVAPQEYGIEPEEKEEIGVLTSLPLLRNVVGDLERARNNEECGLTLYFTKESHIHTLVNLVLLSGLPIANRRIPELDYCAHITFELYERNHGRGKSDKEYSIKLSLSEGAHSSNVLDSALDARHSLNVQPRRKLTQHLPYPLVIERLSKHFGRVMDDDDTGPDSPFETIDALQAPVASTAPADDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUE4</accession>
    <name>A0A2G8SUE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUE4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUE4"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="44"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="36864" checksum="1BD1A9F83050033B" modified="2018-01-31" version="1">MSFEYAAVTKSLMFGIALTSAVAGIFDLKHYLNLQLVPHISKHHQYWRLFVHHLACASSSDLLLTELLLYNVGIPIERAFGGVKYASFFIISAVTTMVVSFVALLLAQLIPMTRANFNNIPGGPFAILFAIIYQYMRLVPPAYHFRVFGLGMSDKIWIYAIAFQLTVARLPATLLPTAVGLFVGYMYRSDVLQLKSWRLPPRLVRLAEDWVKPLLGEDKPVRRTHRVLPEPRAPGSARGSRRAVNLADDEVVTTARSAPRRRVPRPSSGTPSTIDVDANTNAAAETLPAGENGSEQARDRADTGAPASAIDTGSGMNPLRDAWDEIAEFRGPTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUL4</accession>
    <name>A0A2G8SUL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPI inositol-deacylase</fullName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_01151</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUL4"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708307" description="GPI inositol-deacylase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="654"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="865"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="13">
        <location>
            <begin position="75"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="14">
        <location>
            <begin position="691"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="752"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL37457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="914" mass="100027" checksum="6C7E72DE79DFE19D" modified="2018-01-31" version="1">MSKLLATLTFFSLLAIALLYYAGLDTHHSLSPQGCRMSWMWPSYVLQTKFDHTWTPLARRYSLWLYREGNLESNELHGSPVLFIPGNAGSSHQVRSIASSAANQYYSAPYQVSPEFADKRYSGLDFFAVEFNEDLSAFHGPTIDTETLYATHAIDYILSLYSEGTSVVVMGHSMGGVIATALLPNPNISAIITMSTPHTLPPVRFDRRIDHIYANNHKSLASDPTPVLSLCGGATDLMIPSESCILSPVVINLSGSVYRRTVFTSALEGCWTGVGHLAMVWCHQVRWRVARAALELVAVKTAEERATVLDKWLRDGNVLPPDYVPTDVHLREGLYHPVPPNQHLLVRDPVGSQTYLLPFPAVGEGQNAYKFVLYASQGSIPPIAPRRPLPFQARVRVCKGQNEISCTPLPPSTLKLIPSPIPGSPFPVPDEGSDESEGIVLFEAHVPLGTGSYVAVTVENGDKRGWVFGGFSEDEPVDVHVGLTSLLISTVNVAVPNGIRVQLNLPILPANSLIVYRLTPKYDPKSSCTSNTVFLPLLTHQSHPSETHYFPLAPTFSRRILLHSHSAAPYIASDHSSGHVLTIHSSGECGVNEVELSVDWWATIGRWGTRYGTAAASWAVGIVAILMYDTWRLVEGGASVPDVKTSLDWFARERLPYLVIASYFASLLPFRRILKIFRRRKEDSAARRPAAALLSIGLVFLVIFILVPWQVAFLGSWLIHFYTCASSLVDLTSSPSSPPGAEAVPLVTIQPESTASPSEPMHSSSPAPDITSRPPSSHHLPLQQQTNAHLHMLLFMTWLLPLVAPVLAVWVRTLATAGLTTPFDGDHNFLYVAPFLVLVEIFGSGDASGFIKSFFAGRPQGKERVSPRWGMVALALVAFFAGPRTTYMVFEVASVAVGWAVMARIAPTYLGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUN2</accession>
    <name>A0A2G8SUN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial distribution and morphology protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MDM34</name>
        <name evidence="13" type="ORF">GSI_01164</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="10">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MDM34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUN2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUN2"/>
    <dbReference type="OrthoDB" id="17927at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21673">
        <property type="entry name" value="SMP_Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03105">
        <property type="entry name" value="Mdm34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027536">
        <property type="entry name" value="MDM34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058825">
        <property type="entry name" value="MDM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28185:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26545">
        <property type="entry name" value="Mdm34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 10" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="12">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="479"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="618"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL37470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="726" mass="79606" checksum="5C9CD1DD2DF91F1E" modified="2018-01-31" version="1">MSFTFKWPRFSEQFHTNAIQMLESALNKGNKPPVIADRIEVVELEMGTQPPELEIRDIGELTMDQFRGIFRLTYAGDAHIVLRTKVQANPLNHKQPDIHLMGGSRGMLAAKHGLVVPMLLRLSQFRLNSYVVLVVSRQKGITLVFKTDPLQNVDINSTFDSIAVIQKFIQREIEGQLRQMFREDLPGIIHRLSQQWVKAKVEAPYLAKNPVAAGPAMSRTRSLDAASTLDPSSYRIPRMPAAGLSPTLASLPRRPSSIAFIPRPRSPSARSMSGVGRRPASSLLSSPASRVASQNITHPPVQDGPTSFPEIENYDPTYGMRPEGIPTKSAFGGLRNLFGPNKGLADLAEEGSEIDGWADDVASPDPSTWEDFLSDGGNVGPSVSEAGDVPEYETVPAVGGGTITRPRVYHSQSQIHVQSPDGDVDDEPPTFRRHPASQPTSPSGMRSPSRPTSLYNPYFAGMTPLYEADFDVHPYSQPSYAAESSAEPLRRAQSIPPVPSLDHSPFVHPSSPASLKTQLSRSSDMTHSVPTPPPPEEEQNLNLGVRIGRPRRLSATSSNLDTFSASSYEHHHHPHPEPKIVLRPTLNGSISKLSTLSHSNHTLSPYTRTLEHFTVRSVPPRDGGMAGPPSAVERQPVKARRKRLHRLGKKPAKLPEAASLKGARDGGAFDESEGSVDLPSSPGSPAPHSEFDASEMDVYFRKRDDLIPRYPNLHPSHVRRRVAHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUY3</accession>
    <name>A0A2G8SUY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUY3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUY3"/>
    <dbReference type="OrthoDB" id="2726860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="234"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="621" mass="69657" checksum="9A4A16F6D11C55B7" modified="2018-01-31" version="1">MWLLSTSRAELHQFLSPEAIPGPYAVLSHVWGKKEQSFEDTRRLETKCRGLKASPRDYASSKIRESCILAEQHGYDWLWSDGPCIDKSSSAAVSEAINSMYVYYSRAEVCYAYLKDVPPGDIFDERIRKAFRESQWHQRGWTLQELIAPRIVIFLSQDWKLLGTKAELADLIEAVTQIPESLLRLETQLASFSIAQRMSWAAHRQTTREEDKAYSLLGIFGIQIPPLYGEGRQSFYRLQEEIMKRFHDTTLFAWQFVSSRTDRALSSTFYHHNHSDDTYLFAPSPLAFCNSSQMRFSPPPFATRRSEDFLHQTTVESDTEPSPIPTLSVTPYGVLAHIPVIELPQGTIAIFFWMNKQDHLGLRLSPCSSSIDSSRLLYDVFPGDSRLVPLSVDENDYIVDGHPVHAVWKKLYIAHRPPPDTLAPDASTSLYIPLNLGVLMPFRVPGGSIHELHVSTGLRLASVSPMTLPWTGSSPVTLTFEPDNDDTRANILPGIELHLGRCTKSVPVGQAPSGRHLGPHWARLVFHDLKYMSPHGDADDGHSCSEDHVEDWPQSMKVIQPPWSQPDGISGLLAPPPAKLCCTPCPLNPGTTLVVEFIVEEAGHGENDRNRGPGGRQRTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLC9</accession>
    <name>A0A2G8RLC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLC9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLC9"/>
    <dbReference type="OrthoDB" id="30289at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF3">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="114"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="339" mass="38238" checksum="8B04A7EB40FA11A6" modified="2018-01-31" version="1">MSAFLSLASSPSSDQPAKGSTITPDVTSGHLTHLTHDQQAALSSFKDILAKARLYSPPSDPDRPRPSHDEPTLLRFLRARRFDPHKASKQFADAEAWRAKHNVEALYATFPVDEFETSRRFYPRWTGRRDKNGLPLYVYRIGSLTTPLQKELNAVPPERRYQRIIALYELMTCFTLRLCSHLPRRVEPTPISSVTTIIDFADVSLPLLWSLRSHLQEASTLATANYPETLSTIVVVNTPSFFPTVWGWIKPWFDEGTRRKVHVLGKDSGPALRTFIDPRDLPKPYGGELEWSFEDEPALDDAIREVIGEMPKGPVVFEDGQVVRPSRPADAPHENGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLE9</accession>
    <name>A0A2G8RLE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLE9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLE9"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="6">
        <location>
            <begin position="536"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="750" mass="82921" checksum="75A27270147B257B" modified="2018-01-31" version="1">MRVPPAFPVSVLGLAAQVPLHSPLNANSSMTTPQTVFKEGAAIFSPKDLVQLPRPGTGTANEAGDLLFVPIAQYSLKDKKNSKSIHIAAVETSISSVDFPLPHGGEAFWLDNRTLAHAVAEGSEKDKVINLYAIPVKIDTAALSLSDSPQHIGKFPTDSATNFRYSAKAGTLVFSDYVHSDGELKKVKENDEAWENRGHTAFVYDETFERHWDTWVGPKSQSLFSVHLSKGSNGKWTLGSDVANLLKGTNHASSTHLTAQAPVEPFGGTDDFDISETHVVYTTKDPQLPKAWHTKQDIYIVDIHGKSAPRELTSGKHGATHSPVFNAAGDKAAWTELDRDGHESDRAKLVIYDLKKDVKYTLTQHWDRTVGSIAFSRDDKTVFFTAGDHARIKIFSLPVPETPSVSSTDPAFSAELRIPREVTSSGTASAIQPLTDGRLLYTRSSLTTPNDVFVLHGLDANTETKPAVAQLTRFAASGLQGKALDAGSDFWFEGAEGKKVHGWLLKPPGFKEGEKKKWPILLMIHGGPEGAWEDGWSNRWNLNIFAQQGYVVVAINPTGSTGFGQAFTDAISEDWGGKPFVDLQKGWKYVLENYPEVDPDRAVAAGASYGGYAINWIQGHPEFGFNFKALVCHDGAFGAQYHGYSTDELFFFNYEWGGRPWEPRAQEVIKKFDPINFVDKWETPMLIIHGSKDYRLPETDGIGAFHALQQRGVASRLVIFPDENHWVLNHQNSLKWHYEVFRWLGKYSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLY6</accession>
    <name>A0A2G8RLY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLY6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLY6"/>
    <dbReference type="OrthoDB" id="192748at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="139" mass="15539" checksum="1D408430663C1716" modified="2018-01-31" version="1">MFSLPPSRTLLRPTSLPRQLRPWARGASRRPSPWPEIQGPPGDQPKLRTWVAPASRIANFLIVPTAILYAVFFADFGDHEHVFSPPRRWLESQKSAFFSLSPEEQKLVGVDAAKSESPAGVQGSGPSRWYALRPTFRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMI1</accession>
    <name>A0A2G8RMI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_15403</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMI1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMI1"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="108"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="218"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="372"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="440"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="503"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="547"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="624"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="632"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL22710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="741" mass="78868" checksum="4A3B7CDDB5564761" modified="2018-01-31" version="1">MAPELKPIDPKTPRWEPTAHPADIVVSGLDTTAPPYDQIEQIEQLITIKLQNIDANFSKIQHAMANRILPAVKRYAVGTQPVREAAKFWTTFYEQAAQIRIPTYDDYSAGQEHTEDGEPSESSQVTSESTPAEPSTTTQSDSDSDGETPHQNRTFDRTPSEVSFAPGQAAVSSTPATAYRSRSRNAHDNTFASQTSEPMPSWSASLESPLMQLNRDIQSLGDERSLAGRPATALEQSEDFDDSQDVTQRAIAPGVLGEEKTTIHASDKGKGREGPQPLLHKVLNRNANSSNLTGTTSRTTSPLKFKPKTPVIKALNPYLPPDGNPSDWKGVVDLKDPAVASPQRSARKLVPPASSSIKLSAYKPSAAFTARANARSGGTGAKTPPPGDEDSFDENFGMSPPVMTDYARLPKLGRTPKQEAAARIMKDLVDVERRGVFGPASAAAKGKGGYGTESSMSSMPTPPSMTRYSRPSYVPPAPSETNSSVVDASLDSIMRRVGLSVPGYSSQKPAPESVAPPSRQPVFSSMSSATSVSVASASSASSAFSTTSSRSAASGSTSHTLQPPPPPEPEPSIHTPQPPQYDFYDDEVIGRGGIGGGDADDSLDSLDYEDQNMGTAPADFLFANQDGHSFDEDSFDSSMGDDDEPTDGTAPPFIVGPGDDGDAFDDDSFDDGQFDGQGEEETVFGVPPAQRLAQQQAQMAQAGLRMLGEDLLQDTIGIGHQMAMAGRVEESPTPWNGNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMQ1</accession>
    <name>A0A2G8RMQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_15487</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMQ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMQ1"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL22792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="485" mass="53377" checksum="A96E80D31C2C2EFA" modified="2018-01-31" version="1">MGYDTPTVILRGIARYTVVPSDPPENVDSRMSPIVSTTLGEPPFFLYCNHCRWDSAEVGITFEKPTGLAAQLQKFEDSAPESLEFERLKEHFEPFLRASSSSTALPSASSHHVHTNPITAAASSALARDIPGVGKYNPLSRSRIGREKAAHRQEYPDYKSRVEVGNAAALSGEVDVEFLTHLETVDEVASLEQRWTNSWVSPLRSSDLKPLRIPLQSKKSKRCPSCRHILIKPEQKAQSTRFKIKLVAANYLPAIAVTLPHAQAALEMMKRSTAKSASAAAAAEEQQAAGALIAGHSYSFHLAFTNPLYDPIQIRLAKAVASPAQMTDDAEAAERARRSTFQIQLPTAAFPVGAFAEAWEYDDEDEDMFLDDDGMELVDARGKKGKDGRGKARSVGIVEKRANVTIMSGEVLIPKEARGDIRFNMLVSYTYRSDDPEPSEEAEMGTPSRSHGANKGPEMKNFSFYTVVDLGSIMYREEPRLSADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN81</accession>
    <name>A0A2G8RN81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_15672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN81"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN81"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding oxidoreductase/transferase type 4 C-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL22975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="211" mass="23244" checksum="E804D6E65D522691" modified="2018-01-31" version="1">MRATNVHGLSARKWPEKDSLFFKFQGPTARSLQESADIVKKIATKHGGTGFELARNEKEAADLWTDRKNGFYSSLAILPGARGWSTDVCVPPSRLPDLVYATKADLTEHGIVNTIVGHVGDGNFHSLLLFRNDEELVKARAAVKRMVKRALELEGTCTGEHGVGMGKREYLIEELGEGTVELMKTVKKAIDPHNLFNPGKLYPDSPKASKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN86</accession>
    <name>A0A2G8RN86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN86"/>
    <dbReference type="OrthoDB" id="2726318at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="126" mass="13379" checksum="E20B1BD7D47354F5" modified="2018-01-31" version="1">MNSPTDHSPNSDSSSDNDIEDISAPTEQPGLAAGPSAPIQASFFGTSAPKRRLPGGLMMGGPSARDPKTRRKDIRPGGGGGYWDHHMGPGPSRGFKDDLVDTQIVDQLRQQFGDPFDESDLKSATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNZ8</accession>
    <name>A0A2G8RNZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNZ8"/>
    <dbReference type="OrthoDB" id="2735574at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="62082" checksum="4E9E51494E21157E" modified="2018-01-31" version="1">MAPSQLNADVVAIVCDFLQVTDVSDVLSLALVSSSVRPIATRWLLRTCCVPLTSDTSIRKFHSFLFADAPARAPHVRALDINLEWPYFHQTEDHTGNVSLVLDILTSCSRIQHISIDLERALGHFGLSILRAIAAQKRLNSLNIVASVRTVIDLITEIRISCCPLRRITIHSNGYWFPDALEQFLPRIALTLEELEVYIFMVDQDYIQSSCGILTESVFTMTQYFAVRSLSTPSFHGQPLLDHFHHLFPALDTLHLGKLYNDSVREDAYPQVRTANQQAHVRSCVWKKLDLVDCDARMLYVLSLRCPIRRIMLDYCKMDEQRYAADALRENPVPHLKVTLGHGRTMVDELFTPELAGTLTHLTLCMSYYNYISIHSGPEGSCVPRLRWDDVLDKLVSTLRPLHKLTHLRIVFHAAVFVYSDAASPFAPPEEYALTLRGSTFDFDGTAASLVRPFPSLEYIFLTTCGVLSTWDDSNRHVRPMKPYERWHVPRAWRVAKPDTLGRTLQNEERVLVALHDEVAETVIRQEDLTLSQSDEEEIRKCVARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPD7</accession>
    <name>A0A2G8RPD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_14691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPD7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPD7"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL23380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="409" mass="45703" checksum="21B277424E4B70D2" modified="2018-01-31" version="1">MSDFSNAQSFKVAVPDADLDHLHKRLELVCFPDELDGAGWNYGAPLADVKRLAAHWKSGFDWRKAEAKINELPMFTRDIEVDGFGTLNVHYIHQVSDVKGAIPLLFVHGWPGHFLEVRKLLPLLTAGGKDQPSFHVVAPSLPGFGFSEAPHKPGFKGQQYAELLNKLMLSLGYDEYVYQGGDWGHLLGRFVVSHHGHKHVKAWHTNMPLATPPTFTQFPLLYIKFLLTMPFDKVAQRNLAETAKWAVTGRGYFSQQSTRPQTLGYGLSDSPVGLLAWIYEKLVGWSDDYSWTDDEVLEWISIYWFSRAGPTASTRIYYEMTNGGAPTTAPRAPWTSVPLGVAYFPGELARFPKIWSHTLGNLVFESEHDKGGHFAAFEVPEKLAGDLRKMYAKGGVAYDVVPGKTGYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPL1</accession>
    <name>A0A2G8RPL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPL1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPL1"/>
    <dbReference type="OrthoDB" id="3267892at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="71763" checksum="6EDED721457911B2" modified="2018-01-31" version="1">MESTTMTETMPTASTTRPEPEPPTHEQVPSTSDSELESSSSTHQLQPTPEERARICKEAMRDFKRGGDIIRKTLPLTTLPRWLDPLWVDVDDPTRLPLCWYGVPFIPKLVYAYAEHMRLASYYTQEVDRFMPGDLDQLRTWANMQDWFEKETGVKLELNLVWGEDGVPDHMLTFWSNHEMDNITTKMWDQVCDLLDYMDYEEDDSELMWMLPLPVELVDAIIDIVAELFPEWLLSCALVSREWKPRSMHHLDRIFRAPIITTFDAPQAFMDIVKRHPRLAALATSLEVAPDLASNSAWASYIPFHHLSSRLLPNVRRLVLGKALRWADYPPFYRTVGTGAFLFTGVTTIDLSCHFDSVPDLFRALMILKPILDVCGDAVVNLSVVCPQMSAVSIKISVPVESDDPTNHAGVEKLSRLLLAPLSKPDIRYSFDLIRCPEHNAVGVRVTDTTLSRLQVIIQILAKADPGMTQCQECLKRNSALQGQEDLTKSAPIGAPRPAASSFWQARPQIVIPNVQRSASFSPPPLPSSPPTTPGSSVSSRTDAVSSKRPFTPNDDDEDDDMLERLTHARMELDEPMPKKPRKKRRAARNSWKGWVEGSPPPSEKLINLDSVTVLAERKTRSGRGFDAIGSGRDGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRD3</accession>
    <name>A0A2G8RRD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13649</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRD3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRD3"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="7"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL23898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="325" mass="35936" checksum="0EBDBBBBB7A83B9C" modified="2018-01-31" version="1">MGSTLDIPLHVKYIQSLGENKDDLVYHLTAHLRMNAVYWGLTALCIMGHKDALDRDEMIDFVMSCWDDEAGGFGAHPDHDAHILATLSAIQILTTQNALDRVDIPRVVKFILSLEQESGVFAGDQFGEIDTRFLYIAVNALSLLGHLHELDVEKTVGYIRRCKNFDGGYGAREGAESHASQVFVCVAALAILDKLDEVDHETLAWWLSERQLPNGGLNGRPEKLEDTCYSFWVLSALSILNKIPWINAEKLTAFILSAQDPEGGIADRPGDQPDVFHTHFGVAGLSLLGYPGLEDLDPVYCMPARLIESKGLRKGWAALPRRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRY9</accession>
    <name>A0A2G8RRY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucanase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_14025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRY9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRY9"/>
    <dbReference type="OrthoDB" id="64893at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.40:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 12" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013423713" description="Glucanase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 11">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL24272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="449" mass="46990" checksum="FFF61D2D7317B32C" modified="2018-01-31" version="1">MSKFASLYALLAVLPAIVSAQSPVWGQCGGIGWTGATTCVSGSVCTKQNDYYSQCIPGASTSAPATSSAPGSTSVPSPTSTSGGSTPSTTPAAGNPFVGYTAYLSPYYAAEVQAAAANISDSSLSAKAASIANIPTFTWLDTVSKVPDLGTYLSDASTLQKSTGEKQLVQIVVYDLPDRDCAAKASNGEFTIADGGQEKYFDYIDQIVAQVKQFPDVRVVAVIEPDSLANLVTNLNVQKCANAETTYKACVTYALQQLSSVGVYMYMDAGHAGWLGWPANISPAATLFASMFQSANSSSFIRGLATNVANYNALTAASPDPITQGDPNYDESHYINALGPMLASAGFPAQFIVDQGRSGQQNLRQQWGDWCNIKGAGFGTRPTTNTGYSLIDAIVWVKPGGESDGTSNSSSPRYDSTCSLSDATQPAPEAGTWFQTYFETLVSAANPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS45</accession>
    <name>A0A2G8RS45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_14087</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS45"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS45"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL24334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="465" mass="52033" checksum="16631DA0A549B8BF" modified="2018-01-31" version="1">MHEPRVFYNTLLSMIRNARHRVFLSSLYIGHEDVELISAIQESLRDNPSLHVYLHLDLNRSTRPGPDSPARVLLPLLQQHPDRVHVSLFRSPKLKGLMARIVPPRFNEGWGTWHPKIYGVDDTLIISGANLNTSYFSNRQDRYLQFTAQPRLADYCFSFLKAASTFSYSLLPSSSSTDDYTLHWSHSDTHPHQIEAKAQQALLSLQKAHLAASEVSLVKHSEKGISGQPDGEDDVLIFPVIQAGQFDIREEERCLSLLFRELAAQQRYSVSPASGYEGPVVDLTSGYFALYKPYQSAVIESRLACRILAASPRANGFYKSRGVSGRIPEAYTLFERRFMNAVRAAGTEWPSNSSDVAPGVQLHEWQRGGWTYHAKGIWVRPTPASTPALTLFGSTNLNSRSANLDTELSFVLATTSPALRQRLAEEVDGLREHATPWRGQDSSDDDARRVRLGTRALVAFVGGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSG3</accession>
    <name>A0A2G8RSG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSG3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="63" mass="6908" checksum="C3ED5FFE17E3273E" modified="2018-01-31" version="1">MSSPLENYMGGRDVDVIVTVLAQLRCSKGKHRGAHTIAAVNLTRADYPLWHKSDLRAAMGSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSV1</accession>
    <name>A0A2G8RSV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSV1"/>
    <dbReference type="OrthoDB" id="2757612at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="304" mass="33693" checksum="4AB33ACDEF4EDAA0" modified="2018-01-31" version="1">MSNVGIDTWNLISGMIGVLTVLPFIWAFVRYQHPESKMAELESALKDTECLIHSTISLTLPPILRGALSRPLLPLSRGRYRYRYCMKTEALREETFIVSVSWRKALVAWSQGLSKRISILCGQVKKTRAGICRTIATALPSSLINLLVYRSPAAETADTASQRSPTPAVDPSAASTDDSDTRRASNKSHREASSYRSKPRRSPSRMLRVAADSRDLRMLTSAIRRIDRDLTAQGISHVLLTQLAQTTRKQWSPASTRAHRPRSRQSRGARPGPGPNDAVPSRHARQPSIDSNTYTSGEETACEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSX0</accession>
    <name>A0A2G8RSX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSX0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSX0"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF4">
        <property type="entry name" value="SSX FAMILY MEMBER 2 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="324"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="561"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="749"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="759"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="800" mass="85209" checksum="ADF3629E30DE19D4" modified="2018-01-31" version="1">MSRTEDLSTKLRTLSYDHERLTSMYKTETEKAANAEREMNLQKTRATAASKSLQSSETAHKHTTAELQRTRTTLHSLRATHQTEIKKLEKEKERMVERWTKLSDSQLKVGSLPAGMTCSNLAVVEASDVQLRGKGQGFLDVALEQAESARKELLEQNRRLRGLLLNTVNEMQSVLYGARPVGDTDTGPEPVPISFDALFQNRPADAAGETFNNLFASLRETLSRKAESSSMSCSCSSQKQSSSHSVQSRTPPTKVQDSAEIERLQAVIDKLHADIGQSQKQAAASAAQTQELFDRYAEDQRLAASNLGEMSVDLITAPARDEEKQRLDARFTELERERRKFTEAAVRLGKEKAALEAERLKLLEEKRSWEVEKMLADLPPTPAPALAAPVSAIPPSVAVRHSPRKSPRKPKGKTASPRKTRVSRRSSGLGVVLSPKAKAPAKGKVTPAYETEVIPSTIPPSPVRPPPEFKTSMAAPPHPSPAILTSTFVLPPPSPAALFPSREQGGGTKLPPIPPLPKLEIPPPSSDTSEDDIMDISAEPTSSASSSCASTSASTYSCASVPPPSAPPIPSTPIARPFPVAKPFAQRMVHAYSPVKPSPLSRILMLADSPESPEGPALDPLAEVDENSMDLDTSHIPARAQLSLAEELGVSEDDDSPLREKAPVPSKPAPPASRKVGGAAAAEKGKGKGKARAEPAPPPPQPQGPQTRTSRARAGATLEKENVKRAKLNPPSTAAGGSKDAKKPPPSKPASGVGARTRSGGGAGAGGGGWGTVVKPPSRGGPRRVPIGSAEAAPVPSWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSY8</accession>
    <name>A0A2G8RSY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSY8"/>
    <dbReference type="OrthoDB" id="2744098at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="340" mass="37984" checksum="30C3E0A700E51570" modified="2018-01-31" version="1">MVSQVTLNDLHDNNYGLFAVLAFLGYEHLITFDTEVALFWQKRFSGASLLFFVNRYLTIAWAIATAASPYYSSAERFVLPHAVQLSSFLYFPWAVFSALRVYALGRIWSLAAIVFVLSMMPNITKFAATFCIMLTTGLPDHSPDCKTVQGPITKQLANTLIQFEETRPTFTVQRPPVTIVTRTSLIAAELIVLVVSWITTYRRGTFRGKSGEKHTVAHVVLLNGTTYFLAMLFLNCLQLGFTLAAVGPTRKVLNVSEVTTFSEPITSVLITRFLCDLQRANQRDVVNLDSTGPVSSHSSSEMIISPHTMRFRSMFDSFGSVLVREGDESAHDDTEYEATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT87</accession>
    <name>A0A2G8RT87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT87"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT87"/>
    <dbReference type="OrthoDB" id="2802734at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="215"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="404" mass="45046" checksum="2E3A811C57D2CB35" modified="2018-01-31" version="1">MREVDAQTFSDMVPGSPPIAADREKFLKPNFTKKNMSEYAIGIQLTKTIKSVFQTAASDGMRVLHSPPHKVSGCLYQMSDAFNRVGIYLDNETARRATTLSAADGAKKLTREQVESGDFGRHSWHWIAVLGVVKGFHNPECAFDMGRAPSMSSDFIFEEDSDWLDSDDDAEGVQPPSVPNALLDSMDDEDGSSDTSSDDGDSEPCTGRAGTKESAVSELADFMYNLATRQHRTFTYGFYVQWRRARLLYFDRTGILVSESFDWTKPTSPLHDFVWKLAHMTPTELGYDPTAQQASFEDMVKVYQKAMDPLLSEAIRGYINSAFFSTTEQSDLDQFPIYKLTVPTPHSSPEEEFLDSERRLLPAAAQESQRAFLVGRPHFTAEDLIGQIRAATSPSTSRRSDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTC5</accession>
    <name>A0A2G8RTC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTC5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTC5"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="226" mass="24427" checksum="E75D7C76E97985DE" modified="2018-01-31" version="1">MSALELSTPTRDVPHPFDQRSADIILRTSDSVDFHVHSHILSQVSPVFATMFELPQPAAPPPSSEPKDLAGIHPVTDVTEDSKALEPLLRLCYPDPIPGHDLHDLHDIQPALEAAIKYDMARPTEELAARFLACTPQSPPQVWVFGCRHGLENVARGGAEALRKVLLRGASELLLSPDPMDIPPSSRGLEGISAGQYFRLLQFVCCRGGVRDAATTACDGSNSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTF1</accession>
    <name>A0A2G8RTF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTF1"/>
    <dbReference type="OrthoDB" id="2797179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="304" mass="33787" checksum="30018363A09AF9FE" modified="2018-01-31" version="1">MPSTFKHEPFEATLARLTAPPPSTPCRTLFPQLQPSVDEILRTLSSTDADVFRSVLVRTLLIYRNPSGAPYLPPLPAEAATIPLVALCYTGMKQAMLDMTLAVVGQAREQPISTYLLFVNAPAAFMFCDPNSDPQRRDDLHFAARAALRFTTAELHDKVLEVTMRCRTSWETFRPLFTFRHTCAAALGPLVDLMPPPAGALGEYAWTWRTCARCANHTGRGRCGPFCADAPWFVELWKQLVAILRARPDPDAVIMWGKEHFARALQEAMACPNCAKVAQEHLRCFEGLLVVEAAKCIAEVPFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUY6</accession>
    <name>A0A2G8RUY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_13183</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUY6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUY6"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="173"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL25294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="348" mass="38345" checksum="E91EE4E7FA7AA10F" modified="2018-01-31" version="1">MSSENTEPIPVPPPATDVPASTIEPTPAATTAAVVSELEPTPAASAPEPTPASVAEATAKSEEPTPAEPSVVAVEDKKEDDEPQNELTKKFTEDEWKAVKELRTQLPSIFEKACPDTKPVPSSITIWGVELSTTPSAKASVILVKFLRARTLAVSDAADMLAATLKWRAEMDIDAIMQEKFDQDLFGRLGKVYGKDKDGRPIAWNLYGEVKDMKAVFGDTQKFIRWRVQFMEQSIEFLDFETIDQMVQIHDYEGVSMTSRDAAQKAAAKEATTVFQNYYPEFLSRKFFINVPTLLTWVFWLFKPLISAATLAKMAVVGTGAKTIGAELSLVIDVKELPKRYGGEADDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV52</accession>
    <name>A0A2G8RV52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV52"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573926" description="Transporter" evidence="2">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31905" checksum="7C0D2F523C41ABBD" modified="2018-01-31" version="1">MLPQLLAAAILAKAVALLVFAAGPAPGQIKNLVTFGDSYTDVMSSKDGGIVRPVYAAQEGNFSLFPFAKSGATCSNTLTPRPFLSVFEYQLPTYFAEKANGSLGALRPEQTIYTLWIGTNDTLYNSGARNFIFQNMIPLETTPLYSANSYPSLYWTVQRNTTEWSVFMKELTTAGNAIARLQLELLAPTLHGAHIGLFDSHSLFTEIYAHPELYLNGTAPLNVTGSAHACVLQLNESVSDPGVCTDAVGTDQASYLWYDELHPSEQTDRIVAKAISDVIHRRSEQWITWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVL4</accession>
    <name>A0A2G8RVL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000046">
        <property type="protein sequence ID" value="PIL25566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVL4"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="256" mass="28430" checksum="D4E39077946CF59B" modified="2018-01-31" version="1">MSPQVGQITLYNNHAVFWCHRVRIALAQAGAEYTLYNVDLDNKPEWFNEKVNAAGKVPTLAYGGSQTLPEDPSPESAKLTESTVIVEFIADLFPAARLLPADPVLRARARHFVHHFDAKVAMPLLGFLAVGQSTGSCIDALEGLQALLPEHNEHEHEDGQRQLERSGPGFAFGEPSVADIAVAPFLITGIVLLENDIGAYTSEEGQRALEEIRSPRLARLRAYVEFLREWPAFKDTFDKATTLAAWRKAPRMRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVX0</accession>
    <name>A0A2G8RVX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVX0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013694835" description="Transporter" evidence="1">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13657" checksum="43940BF31754C245" modified="2018-01-31" version="1">MARPFSLRYGIPRESFIFALLSLLSICLAFPIPPPKPRVPRVYPSTRLPCVLCSVANNGDLHSRVNPRRLRMAREAGPSFCYFSDEPIGPFCPIPTGFSGRFRLEDVEILARQSTVFLMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVX2</accession>
    <name>A0A2G8RVX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVX2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVX2"/>
    <dbReference type="OrthoDB" id="10637181at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="301" mass="30257" checksum="84C02C15B688200D" modified="2018-01-31" version="1">MVHVRLVIERSDEFSSIKRGGGTGQLTIDLLPSFLSQYLLTRNQLDSPSTMMRMLSFVVAALAIYGSAVPLKGAVTTIPIEPSLSEVTTITVDSTAASPTAVTTTTEGGSPTTITLLPSGSPTTVTADPTTVFPSGSPTTVTFNPSTACPTGSVTTITFDPSTAFPSGSATTVTFDPSTAFPSGSPTTVTIDQSTASPSASATTITVDPTTASPSASATTITFDPSTAFPSGSATTVTFDPSIVDAFDRTVTTVTVEPSTSVGGVTTVTFEPGTGGVTTTAVDPTTTTGSVVTLTAVPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWN0</accession>
    <name>A0A2G8RWN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWN0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWN0"/>
    <dbReference type="OrthoDB" id="2959108at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041177">
        <property type="entry name" value="GEN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF75">
        <property type="entry name" value="ENDONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18380">
        <property type="entry name" value="GEN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG-I" evidence="2">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="974" mass="105580" checksum="43A663492CBF1CD3" modified="2018-01-31" version="1">MRSLTHLSVKDGFEANPHGKRGFRIGIDASIWFYHATYGREGENPELRTLFFRCKTLMTMPFLPLFVFDGPNRPEIKRGKRISGKNHWMIQGMQEIITAFGFEWQAEAELAYLNRIGVIDAVLSDDVDTFLFGAKMVVRNPSTNLSGNRAHSLKNSAGRDDGNHVMTYSSADLLAHPNIQLTQGGFVLVGVLSGGDYSDGLRGCGVQIAHGLAKAGFGDTLLHAARTLSRDALDAFLVGWRAELRTELRTNAKGCLPRKCAALSKTIPEDFPDIDVLLAYTNPVTSEAKGRAHRNAVVDWDKEPDLGRIAGVCEMYFEWGVRHIIIKRFRTVLWPAAVLRILRRAAILKDRKEGTRAEGQKQLPPMTPRKNGKERRAPPGTPSSMIAKHFSGMALNSPQRRGADEATDDDADDEDEDDPLIVKIHSSRQHASTDQILEYRLEIAPAQLVRLCEAGIKGLRTALPPDLSDDDDDEDDDGDDEGGGKKKGKKGKKPPPDPDSHLRLWLPACMVAMVEPEMVDEFEGVQKWKAEKKAAKGKKAAGSGKATAATATAAKKTKAKAPPVAAVPEEEEESSGEDSEPPLPPKPKGGKAKASTSTGADKPTTKRGTTNKPSAIGGSKIDEFFAAKKTMNKVTTGKPAKAVAKSSTSKVPALFKDLSSDSDEEPSTSKRPPPALQKISSNTRPSLTTASSSSRFLSFLDSRPQHRPTGPSKASVSPSKARTPQPFPMDFDAYPLNKPSTSLASDLDEDLFTPGAGPSSQSSSRAHTRTRSTLSSESSSSDTRPSASARAHKSPRRSEKHSSPRNSPRKARGRETQRTPRKEEEEESSESDSDPALGRRPSSPSPIKGQIRLPTTLGTRAYGFTHARRQEEEESDHPPSSSARPKKLVPLPASSKASARPTAARKPKPPAPLPGNMTIISISSGSEPDDDLPPPKPTTKVAPLELARARLGLASTGNKPPRRAYNPEDVIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWS8</accession>
    <name>A0A2G8RWS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RWS8"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 10 N-terminal" evidence="2">
        <location>
            <begin position="264"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Utp10/HEAT1 HEAT-repeats" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1858" mass="200875" checksum="D568B0228DE80D37" modified="2018-01-31" version="1">MTSSLAQQLAKGASLNANLLNEKSRRQAASESYLFSPKEARQHDIDSLHALGVNGFLQLKSLLSDVARFEHSLFSDAAKSLDRTLLPKEQNADLNSTIAAFLPLLGPYLLDVPSGKVLEWLVRRFRIHEFNVSSIVSLFLPYHETPHFTKMVSILHVSDSSPLRFLQAYKATVKPVHRPLLINDLLSKPEVARFAAAILPATLRDYAAGVHRALIAFHAGVLLEYIAKAKALDENVMTFLLPAAMEPLQSASESHSEVRPALLHESILGGYLILAAISQRTRLTSKATKTILGAIVECAERVSPKQLVRTLVSVCAPQDQLEKLSGSLVKVLIAIPGISSELVGAMAWTGAEKFLNPFIDNVLSRVDDASALAIAEAFLTSPGLLPTIARSSAASLLRRLVDEDLTDSFASWKSLLSQLHQRQPKAVQGASQSIIDENAAHRDAIEQVLLSLTMPIAAGSTADTETATLLVGSSNADVNVRAKAVRDLVSRLADDSVPETEMQSVASTLVLRVHDADASVLQALYATSPEASANALLSISAGAAYLDALRQVLHSPSAKPSRDVVRAHLTFLLSHFLPAASGTSADDEQEEEDSEEVRERSRRVFMDILLPFMLYSKPRVKTAQAVWEILDTAEGEATGRVAFELLGGCVEVVRWERARPGASKSGDKDGVDPELLTKINLAVAAKIADNILVSNYFSAHLDLLLVKLGDDNPHGRALSYLITRALLARLSGDQRVDAGHRVLNAMKLTTLEGMGDFMRGIVDVGQFLDDASVGSAVVLKPSSQNTLRRLQVSVLSVLPNFPRPSGVSLDWLAEYPLQLGGAVAADNRASRYIQLLRAVYHLSNSSPSLPLLSTHLLRTLFINLGDEALSFLAGIWLTASAESQDGEGKAHIEYAALRHAGAFLEAHVQAKRTLDFQTALPAMLVALQSADAGVREAAVRCIAVVVKLSFASEAEGVYAFDAIYGAESAALQYLDWADFQKYMKAIADNRDNLIHDPAYLQAFHRDHLGLTKGDSKKTAGYKQHILCYLLSHVNCCPLLNFKVALLKSVDSVSNEVKAQVLTPTIERLLAAEQDCQNASKRRMLQDLATFAVSSFDALSAGDLNDAGKPIWDVYLKILTTTLKHSVWELARVALIHRLQHGLFIKLDNDRRTQLCRTLIQVGAGDESLAPVCKRALASLLSDVPLIIRLLVSFQPVSTADPVAQPASKRPRVEKTGHPHGEELSALALLVEVVGSLKIAASLELVSGLLETLNKVASHATPDAADVRFIEQLLMSAVENVVGSFPTSATVAPGSVRVDTLVEILRTSDNPQTFHQACLLMATLARIAPDAVLHNVMPIFTFMGSNVFHRDDTYSFRVVQKTIDSIVPVMVASLKAQHGSGMDLYHASKEFLRVFTNAANHVPRHRRVNFFSHLVDALGPADFLAPTAMLLIDRVSNRVMRQSATESSGSLFLPLTVHERYPADLQLSSLVQFVHEVRRLGLNDDASVHPFLEDTSDDEQAHADQAAKRRAIALLVFCDHALKCLRTTSLARSDKERETSQELLGLLLATSTARPEDASFSEVADAARSAMASTLGVMSAPDFMAGIVSILESGSIHAQTGALELLGERLKQVAEKARAALSSSVVKVVDVIRRIASTARDPALVRSALQSLAAIGDTLAPGEEGTVSAAVPSVLGCVSRSESRLPALAALLAFSSKMGPRAIPHLKDIVKECVQCARQAISSEADSAVIPAISSILHNLLTSIATFWGESELVKVIELCLDSSQSSTADASEMSLLVRTVAKRASPNVLLPTLCNMWTSTVLPKAKDQPTRTTAYIQIVQVSIKAASRPAVLENLRELFKTFLSIFDFCTSSGSPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWW9</accession>
    <name>A0A2G8RWW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWW9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWW9"/>
    <dbReference type="OrthoDB" id="2522283at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48099" checksum="CA623EBF31E6BBA6" modified="2018-01-31" version="1">MHLPTQPSRCYGLPIELVLEVLQEAQYHDLVPRYKWLKNYALVCRAWSPYAQQLLFAYVALLGGADHCKIFRKIVALSAARDPEHAAFLKSSICVLGMVIDHQPFYADIVHLCPNLRELHLSLYHGSFRPDVLRSLAEGGVRLKALRVKTYHYLPMFQLLSVLPSLEYLEVDCNSVLGNTLIIPPLYPPAWPLRHLRYSNLRRNTHLFLEWALSGPGAVARESLEVLEVVSPSFDPSTIATLGIAPTLRSLTLQRLFDSDDLTALTSLQEIAVVHPSGTPPTFRLLPAGVVHVALGAIPKTSGCATTVAGLAAYHERLGGSLRALTYNRKCDSSVDPPLMDVDMLYHFCAGRGIEFRLMDPPYGFYPGERVPLKPVRSFPRDLPMSSRRPLHAQGEELPWKTRRKATFARKIVNVASRAFGGTIPAMALAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXA0</accession>
    <name>A0A2G8RXA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_11871</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXA0"/>
    <dbReference type="OrthoDB" id="2749455at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL26117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="426" mass="47266" checksum="6BA8D8ED36A1826D" modified="2018-01-31" version="1">MAPYWIAQVDAPAALSLVGFVLITIPLCWHLRAWNTGCVLYIFWIGGVCLANGINMLLWRENAINFAPAWCDIYIRFYIASSVGVVSSSLVITHRLYHIANMTATAMDTSAARRRRKIIIDLLIGLGIPLLAVALFWFYQGHRFNILEGVGCVEAYPNTFLSILLTTSWPIPIGLTTAVYAFLSLRGALDRTRDLKQLQVVEPDLSTSCYYRLMALAAANILFTIPLSIYMIVTNLSEGLYLYRGFADLHSGFGRVESTAAIVWRQNATVVSLMNFRIWTPIACAIFFFVMFGFTAEARMQYRRALASVAKPFGVVLFRQPRAASEVSTLHFRRRSVVESGFWDSEDWQMTKPGLLAMDDADGPSTRLVGSGECSRALPLGTSGVSVYRIERSSKKGDIVVMAPVTEPPPAYTKSPPSMRSPLDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY60</accession>
    <name>A0A2G8RY60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY60"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="270" mass="28484" checksum="09AD230C14C5CBCF" modified="2018-01-31" version="1">MPSYAVIGASRGIGLEYVRQLASRPDTSVFAIVRNPAGSTHLQAVAAGLKNVHIIASDVADYSTLEHAAKQVAEVTEGKLDCLIHNAANMDINTVHKGFDDYTTMEELDSEFTSAFKVNSLGPIHSITAFLPLLRASNTKKIVVIGSGAGDLKAIQALNIANMVAYGMTKAAAVIATTKFAIKLKDEGFVVVTLAPGMVDTSATAGTDEDVVAEGYAAFTSLVKEYTGIQIAVQTPQASVAAQLRTIDGLEASRNGLFLSHRSGEYRPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ29</accession>
    <name>A0A2G8RZ29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ29"/>
    <dbReference type="OrthoDB" id="2750039at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="438" mass="47245" checksum="C0AB5B55422B9C3C" modified="2018-01-31" version="1">MGIRLVRAPEPELRPVFINDLALNTTLFYAEDLSYTALDIGLSSALFGVLTLLVAIALVFLMQVRLIPRKGFGHTPARILLPSTLLLYGSTVLFMASLVGHVASVNRLVARAQAGLFSDAYTNADLDAFQDDVLRHSWMMTVALGTNLLIGDSIVWWRVCAVWRSRVVYCTGPLLIVLVFAFGAKALCGEQRCLDPPQQPQTLLRADVFTNACAVLSLAVNALATVLIGYKAWAHRRLLRGRFGRGRGRQWHWQSRGVMDALALLVESGTIYCLLLIMVVVYQATPALFPTPAVHQSAVLSVVADYTYACFVPVIAIYPVLIIVIVALNWSPIEHCGLASGAGDCTHGAADVDAYEGRYLSTVQTATATHLDLDGDGDGDGDGVTMSTIVRSDSDTVQISMQMRGLQLQTRPRSTSGEDGAVDAETQTKPAGVAVAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZF0</accession>
    <name>A0A2G8RZF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZF0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZF0"/>
    <dbReference type="OrthoDB" id="3256413at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="535" mass="59105" checksum="31D7CE1035F8A0DC" modified="2018-01-31" version="1">MSLLSLPSELIVAILNELRIRDLLRCREVCTKFKTIIDDDVRAEYKVELAVSGMQDGISSPLTLVERLSILRTRQKAWNEFAWTAQENVPMHRGYAWELSGNVLAQPDGPGERTLHFKQIPSAVRGIEGIEWTIPDVGCGMAGFGMDPTQDLLVIIEHFWNENSEFMCRLHLKALSTGAPHPAGPPEGMLTPQSTRCPSSHFIETSENHLGFLIVYGGSKELVVWDWKLGTLQLHLTGSEIGSWAFLTSRLILIAKMHSRYNEETRRMVYIPHLVVIDLESHASSACESPEPVALSDANVVGTFHFPPLTDHIVALDMIIRSNSKPTHNEPPPPSPKRRSAVLALGRPGAPPLPLVPAIGSSETQAEHDVAWAEWGKHGARLFATSGYRTATSSEVCYVHGTAFVTTQVDSDPDPEAALDDSVRTTVIVRDFNQLALRRHAHAADRGSKSGGKYSSGIEEQSVRVVTEATVWEPAGMFKEEVTTSLPYAERVLVLSQSEKGEDNTSWDEVIPTEDAFVLVTSTSDSRFRCRIMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZJ1</accession>
    <name>A0A2G8RZJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZJ1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="40790" checksum="988F4460C8DE4487" modified="2018-01-31" version="1">MASNSQTITIWNSSAEVVQTILTEAGDTSIPDPPTIGRMHMSASLLPPIETEGLQRRYPFVAELGDIFLKALKVHEILCSRGILLRNITIETVMTLAAAWSDHDRKDVAAIAPGGIISQARDPQNATSEFLSEWETACLHPDAIRGVAPATNIADSRLVEPGSYTKVTPGDFTTNTPIFFATEVLLGLRKNRKVVVTKAHYLESFEWVFLYAVYERCIESASTGTYAAQRILPALLNEFHTIFALTVDPPALATHREVLLARPTDPQDDHFEKIRALLSFVEHVVESEELLGVLMDVWQDLKERLLTLYTWAGRPPVRPGSFFQKDPKGDCVPPNEESFRCMEHRDLIWCLESLILPREGRNLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S089</accession>
    <name>A0A2G8S089_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_10324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S089"/>
    <dbReference type="STRING" id="1077348.A0A2G8S089"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL27182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="149" mass="16894" checksum="B3AFB0EC71F4334E" modified="2018-01-31" version="1">MALPKRIIKETERLVADPAPGITAAPHDDNLRYFDVTIQGPDGSPFQNGVFRLELFLPEEYPMSPPKVRFLTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSVQALLSAPNPDDPLATDVAKHYKENEKDAQRVSREWTEKYASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S178</accession>
    <name>A0A2G8S178_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S178"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="110" mass="12171" checksum="A636846D37F07C6A" modified="2018-01-31" version="1">MWRFYDRGSGTADLVFDEVLLDDSIGEQAAKIFLEWMHGAYPHRIANVVQKRGVALNLWRGMIAANRRIGDRAIAGGIVGMTLAAYSMDDDLVVDAKSRSYGIKGGRQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1U8</accession>
    <name>A0A2G8S1U8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1U8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1U8"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="263" mass="28846" checksum="E2372FCB87F44A01" modified="2018-01-31" version="1">MRTHGLSCLLEPNLRTRFLVKSLEIEALQQMLGVYITNSPYTRTCIYAQPPCATDDVWNPYQSELPSVDLPWLAKQGKPPTPASYSLNETACGGIDGSTDACVGTEMGPDGCGVCTVLRTAKGRYGSRVAGTDCAAMSHVDAVSRISDECAVRSRLARWSVDDDATACNEDQPPDTPSPAIQASQTTISAEARHVLQYESQQNTTGIDHVKPHAREVPRSPASRWMGKRDVPSDRDHDHVPHPGLGHVNEDWTRIPDYRRHLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S300</accession>
    <name>A0A2G8S300_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_09686</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S300"/>
    <dbReference type="STRING" id="1077348.A0A2G8S300"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000350">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="8">
        <location>
            <begin position="89"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 beta-propeller" evidence="8">
        <location>
            <begin position="383"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="6">
        <location>
            <begin position="716"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL28149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="992" mass="110315" checksum="93B234998D62AC60" modified="2018-01-31" version="1">MSAKPGDNGVANPTQEDEQNAGICASPDNMTEVSSEDGHGEEDGVGTNGSVAGENGQATESEEYGSEEDVTDEEDQEDEDEDDDEEPALKYERLGGISHQLLQKDSASALAYANQRLALGTHGGKLHVLDLAGQPIKSFAAHSASVLDISMDITGDWIATASIDGQVAVYSLSNPETYVFNMKRPLRTVALEPNFAKSSTRSLVSGGMAGNLILHEKGWLGYKETVLHSGEGPVWQVRWCDHLIAWANDLGVKIYDTHSQSRITFIDRPADSPRADLFKCTLHWQDENTLLIGWADQIKVARVRTRPRKSAASNLHPLLVEITAVFQLDCMISGIVPHLMTPSPSAPQPRDTAVKNGSVRSTMSPILTSFLVVAYTVPDTALLTGNEATADRAEQARKLAERPELRIISRGGEELSADALGISGYERWGCNDYVLVDIDAAAAKGSSPSSSAGHDGDRYYIVLSPRDIVVVKPRDWRDHVAWLVERKRYEEALDVIERMGQDDSVAKGDKDDLDAVQIGERYIEHLVGEGDFVKAARLCPKVCGQDSKRWENWIFVFAQKHELQAIIPFIPTESPTLGHLVYEMILAHFLTHDRQTLLQTIKTWPKGIYDVPAVIVAVQSELDRAPSSSSKKATGPETVILMECLAELYTLNRQPGKALPYFLRLRRPNVFDLIRENNLFTDVQDQALLLVEFDQELREKRKKDGEDVDTDPVAAITLLVDHIHSIPMARVAQQLQDRPYYLYLYLNALFQNDPHLTSPYADTQVKLYAEYAPRKLIDFLRASSYYSLEEAYKVCNERDLVLEMVFLLGRMGNNKKALHIIIERLGDVNRAIDFAKEQHDDDLWEDLLRYSETRPAFIRGLLENVGAEIDPIRLIRRIKNGLEIPGLKSALIKILHDFTLQVSLLEGCQTILNGDCADFVQKLNRNQTSGFFLSDCVQHDEDLPHQPDPTLVGMGIGGQPGLSGKVAFTAILRARLPQGCPVCHKRSEGQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3D4</accession>
    <name>A0A2G8S3D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3D4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3D4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="444" mass="48132" checksum="AB5031A4090C42C9" modified="2018-01-31" version="1">MLDKRAREEAERISQLDFLPSSDEEPLATQLALAQPGGADASDRRRPQPTARNKVRTPTHSDAQLQRNTRDSEDDDDVDIFIASHLQRHVDSTLHTPPGSPMAVDNTQELERAPSDLEESDDPRGDGPLVGELGRSKDGARQPLPSQKSQGGRGGRSAESNVRAPREVPPKPKKLTEAEKKKLRVALVRSQVDGARQAQTPVVPSAALKCPAETSTSAKKTKKRKEEDAFTPDYRARIRDAVASPSIQALRPSDSHDDMSGDCGLQFLDVTSARSTSAAGPSQPNPPAHALWKYAPFTFEASDQDSGSPAPRTSLAIQQPEHAALSDEEIGRFEDDDVAVSRQAVVARKKPIVNVSPKLFHLPPASSTHASQMVAILPNATIEGDSVVPASTKKPRGPRSQVSVTVSRAFFALDNWVQETVLTKIVPSLIVWERVGRDDGEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3U1</accession>
    <name>A0A2G8S3U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3U1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="377" mass="40769" checksum="4A3AE8A7298692B8" modified="2018-01-31" version="1">MTTSPAVRGVVESAYCITGRRAGQRLNDGAGWKLEMDSDGAAPATSRHESSIILQEADGHGGDASKARRRCQRMRQPRRGVAPRPWPFRFGTCYAREPAGLAARMASRQMPLAFPGASVLLPGSSRASTLQHAPASSWNTNTAPSCCSARHTNGARYANVSLRGRGVAPNYGWKAIARRTSCPGRRNALRRAGRFLRMIIDADGVRDHAPSRISNPRHLPPCVLRSACRLLCDEECPLAHPNFCSCSRPASEGLPVCVPRPAFDTIGVSSSDSTYDRNLPFEMRTSESRGRAQVKHAGRAAGLRLLPAIPGTGRTQSLDQLKRVACELEADTAPATLNGECDSLLTRSNCNYEKLHMRADDSDEMTLAREGAASACF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4A9</accession>
    <name>A0A2G8S4A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4A9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4A9"/>
    <dbReference type="OrthoDB" id="3250989at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="707" mass="78728" checksum="DDA3550C91A77E03" modified="2018-01-31" version="1">MTLPFYRPLSQRPTLRQCDSVIPVLSDTQAPPLLAKRRMFIEKSQALLASGEEMLSDDDASKSSRDNPHHHPNLGSWATIHEPVFAYATTALEGFLPVNPEVRALDENLEVIDGKAFDIRICAYDLCEAVQHVKHTPDSTHMEALKGLLRDLFDDPDLQVNVKQVREDGGRVSTELEIIGECHTAHGLPAPYIMGKEKLIPNRRFTAAYEGEGFGAYKRAVVGPKYAAVREMTCCPCLIIDMHGFCMHFYAAYFTDDVYRTHLCDIPLPVNPAWSDAAPGEYSNAFKFQVIRKTARELRKSYARVHTGSALPDAPHLYPQPAHFAASPLPGPLTLVDRVPVSPLALPPARFLVRPPLLFTGVLQTMDGGQKPVHVKFTTDRDYGVAAHRLLAKYELEPEPSDADEDEDTRERTPWPLAPAFLHRLLFPGTYTRMVLMETLGGDTLEHLLASNSGAAVSEADLADIRTAVAVLHRHGFVHGDIRASNVLVQRQDAEEGGRGRTGGPLQSRARAFLLDFDWAGRAGKAKYPVSLDERLEWPRPARELRGRYITKRDDLFMLGKMLALVREREERASGGADHDGLGKQKGIAADEYDDGYDDEGDEDDQETETTSAMLSAKPDDGGEDDDPWSAILTREKVVDFGRAHGAVYPVDINPGIKWPRPAEELRCQPITMAHDNFMFEELLKELEFESAGLGEDEDEDEDEMMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4I7</accession>
    <name>A0A2G8S4I7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4I7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4I7"/>
    <dbReference type="OrthoDB" id="3268787at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="18"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="353" mass="40491" checksum="B7277490492FC172" modified="2018-01-31" version="1">MNPNAVSERHPDLYFPDGDVILAVKQTPHSGAVEPPKYTLFRVHKFLLKHHSTTFANFFADANVAPAEVYDGVPLAEMFGDRAEDFAVLLDYLYNPTSLVFKRNDPNIPLTVSGVIRLSDKYLIEPLRRRLVQEVCAAWPTTLVEYDIKQAEIDSLRALPLNAPLKYRGRLADVIPEPASAILFAQEFDCPQILPAAFYTLSLIPITHDWDAKPRECHEPLAKWSLLDNENLVRYIHGFQSLNKYRPHPIQFLCEHCDVSWNMDGPAEPVNNSSYDYIKRLLDVVWDGAGPSVTHSDPIRLLAKCFNYYDMPELSEKHFPDGLCEGCDRLLSRRLPEERKRLWENLGEWFKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5E1</accession>
    <name>A0A2G8S5E1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase dynein-related AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S5E1"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039891">
        <property type="entry name" value="VWA8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21610:SF9">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="2">
        <location>
            <begin position="73"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="2">
        <location>
            <begin position="454"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="2">
        <location>
            <begin position="789"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1394" mass="155150" checksum="32ED297042304833" modified="2018-01-31" version="1">MANRRLKNVLSGLAPPPPTLGVLKLGDISHDVLAAADPSRLPHSEDVLLDTADPFNLDNLHFLLQKYLLGQDIFLLSQPGPYARRLALTFCRLINSEYEFVALHRDIGETELKQGREIRAGGNLVYVDSAAVRAVKNGRVLIIEGIEKAERGIMPVLNNLLENREMNLDDGTHIVHPHRYALLGTTVTESTTFIPAHKNFRVIAIAAPVPPYPGYPLDPPFRSRFQARFVDPMGALLALQPRPDGSASNTAFTSPLYVKLRDIIASTQIASESRHSLDAVARSSLPAFPQTALAKVTALLSVFSPPEMLSSEHLARLVLSIHPALIHSPFIAWAMLSRQFEDAGLGELGSPNLTGIEDDAGLLGYRLARIDRVDARTARLHFDHSSGMKDVSVAVAAGPQEYLAFPFANPDFLEFIPSARFVGLLTAMLQVHALGWDISYAPPALPSTASCSTTTLVRTFAAVLGYELDDVHMYKELGGRELLMRRKIEEGGATTWEPAPLVEGAWEGRLVHLAGLDVIGSTAGSLARLTQDREVELWEKKRVVRRILNNEVGICFDYRGAVLNVVLKEPSPDLSIAHRAFRMISTASKSLPLKDWLSDEHANMFFPVAAQPMSHAEEEHLLLQTGCPTPVVDALLRFADRYRTSMTADAVQKNRKLGTRALLRIARRVAQFPAAEPDLHTLLSRAVLAEFLPATEAMNLLNICEETGIKKRTSAFNPSPEIRDGGVWFPPPSGPQGGGFGATFIPFFDRSRDPEGVSHIPHMDHFYDNSLQTGLMRDLAIDLEVLGEHLVLLGNQGVGKNKVIDRLCQLLGRPREYIQLHRDTTVNQLMFQTVLENGVIKYTDSPLLRAIQMGRVIVIDEADKAAEHVVAIFRSLAGHGQLTLADGRRVRQMKEREGDIVVHPNFRLILLANRPGYPFLGNHFLQVLGDNFCCHAVTNPDMASERKLLSQLAPQLSEDMILRLVAAFHDLRRAYESGTLTYPYSLRGKFYQLLNLVRHMQAYPSDSLEVALRNVFDFDVYKPETISKLEGILDHHGLAVKKLGIDAAREATKKQILDLKFEPKGDTGLNSPKFGKEDPNNEPHTGGNTWAGGTGGRDTAGLGGRGGYMRLFKGHDINQVSDALKNDVPDHVKERARERAREMARQELARRLEELNMSAGEAKLYGSLLAAVEGHVAQLHDLLENLAAREEERVWVKRQTDGELDDSRLTEGLTGEATVYKRRGMAKPEMGRPQLKPKRIRFLFDVSASMYRFQADGRLRRSMETAVMLMETFDRLTRKEKYVWDIYGHSGDSPEVALVETDKQLELKERWKVVDKMEMITQYTFAGDFTLEAIDKSVTEVAKFDGDDYFVIAITDANFARYNITAEDLRRVMDRNPKVHTALICIGEGAEVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5S6</accession>
    <name>A0A2G8S5S6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5S6"/>
    <dbReference type="OrthoDB" id="3166447at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="468" mass="50960" checksum="F358730DCC1847C8" modified="2018-01-31" version="1">MPLSTMSSTSSPTPSRYPDLPPPRTQSVSEFEVEQRKMPFSPSKNRRRGSEPDAKEVTYRSAIASVVGAKARPFCVSGRVPMDPTQLTLFFRSQSGISHSLDFPIDIDVDMPPALDVLIASCLPHAQRSEYAETETLFYPPSLPLTATLELANHPILEAVRNTLFPALPVGHYLTALRDKLEVWPSGNAPLIQPRPIDNRVATVLITLPVKFRGGVLVVRGTDGREERFHGRGGRPGDLEWAAFMSDCEYEIQTVRSGCRVTIAYAVQVQSFGPAGIQPSPLISPSDAFLDYLSPLLNMSRRRSIAFYLTGDYGVNPGEVVAESLVPNLKGGDSILYHALKLYQLLPELRWTAGGYIWPVDQVVEIVNEGPDSPTASVGRGSLSGSSTGSRRGLFSSSASEPGEEEVDGLRAKVVKSGAIPITDTDIRLLSDQITFPGVISREKVPFVSPVGDMEKLVVNVLMVVYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5X4</accession>
    <name>A0A2G8S5X4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_09225</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5X4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5X4"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL29176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="300" mass="33934" checksum="E32A2986E28511FB" modified="2018-01-31" version="1">MSAGFSTATEEFNKFADVEHADESNLPVDDEEEGAEEAEGGDALTSRKKKLEELRKRMRSSAQANRASVIEESAKAKITAREVARLERQRKLAETLRQKADAEDRGEDVERQKNWEYTIEENDQWEKKLARKARRADFSFNDDADAARRKYKKDLDFIKPDLETYNRQKEIALGLAAGTLAKNGQGSGSSAVTAFDPSSGALVGLSSLQQQLAAESLYRDANSLLYADNKPSEDAVDRVISKINKDVDKKSKFSRKRHNEDEGDITYINERNRVFNKKIARYYDKYTAEIRASFERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S642</accession>
    <name>A0A2G8S642_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S642"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="11980" checksum="1A1D357DACB47114" modified="2018-01-31" version="1">MRGRRMFVLVLPAPCISMCVVFVSRCLYLFSGRTTPAHYSVQIVAFDCGICVGLTNHPHSVYWFVALQLVYTSIYLVDPLVYCYIQDERPRRVMVLGRDQATADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S694</accession>
    <name>A0A2G8S694_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S694"/>
    <dbReference type="STRING" id="1077348.A0A2G8S694"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="403" mass="45102" checksum="962AAA1D421545A3" modified="2018-01-31" version="1">MSKKRVPQGMTPELLDSMQQILQGFKGSDLSDMMRHVSGQDPAMLEAVINAVSDAKEKNQVDLSTFDYASLRIKRDSFWVVQLTQMGFGDPLTGRVADNQFPGSQPVFQIIIYDDRNSYRVLEQADKPGLPPSSFVLQAIQKAMANPIPPLRPQLPEFLLVARKLQQHLPVLKPFLDSFPAPFTWRIETREEEEEVANGVHEMNIAGVKNGIRDAEQEKERGNRAFVNKDRKKAIEHYNKAIDCLLDAESQKPTDAELVKIKAVEAVCFSNRAASWLLPGEGQDAQKALADADRAIEEDCEYAKAYYRKAKALLTLSRTDDAIDALTSALMKPNFAFEKGLNDALVEAYGGFPDTADALRTFCLEKFKNEDGDKRARHVAEFRRRAEAQLKTILGPDATIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6H4</accession>
    <name>A0A2G8S6H4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6H4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6H4"/>
    <dbReference type="OrthoDB" id="2750302at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="3">
        <location>
            <begin position="167"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1039" mass="119413" checksum="2CD93E9F9443199A" modified="2018-01-31" version="1">MKRKSNRSSYSKKVRVKVVEDPADTVLDESGSAAVAGPSSIEVENITFTPAASGHRYGQSTERRTIVPNPAEHVLRPHADLETVDLDDLDPTSSLDSERVHDFFEGSESGTHPAQEPETPLKKTRARPDLRAANKLREWLPFREEFLEELLCYAEEWDGKRFMRTSLRALGLEVQLGHLPGKECLQPGSNARRIVVCHLSGVHEIQVNFCKCLDDTGHESPEWAQLFRVGWFPATTAVPATAFTFDLLKTFQELNFQAKTNLNDFWSTIERLTDNSGGSDVPNRYKQLSHVMRLWRHLTLLKRFGRAHDNTGAAGTSQGELVVECPACPHPEKNLPENWENAAPSLKWLYTLFLMMDANFRARCKDRGFDDIELAPGWAYYVEEKTYQAHILSRANEKEVENTCSAEHNAIRQANLHKEGYIASGIGAVLCARHALVRKNGAGDLQQGERQANMDYLYFSTLLGVVLVILISYDIVCQWARHLFKRMFEWFPSEMHVTQTQLEEMRFAIPKKHFRVHGGSPHSQYSFNYLPRVGRTYGERIETHWSHMNPLALSTREMSIGMRHDVLNDNWGAWNWQKTLEFGYFLLRSLEEAHEMRIKQRRIFREYNATFAPEVVERWEKMVQEWNRDHSQPDPYEEPSTGITMAAVKLELAQQEAIEAHLGQLPPHEVTPAVFLQVALELEEQQRTLRLRAPTGTSISELADQQTKRNVLSRRIELWQAIQDVHMPTVSPLRSEHASRSAAPIKPEDVQLWLPSALPPTYRSVESLSGLQDKERRLHLAQMSDSLEDIRRIRRVLAAISEFKRLNVSGTGQRAVTRTLGVYNRFLVKERRCTERYRAARTAMVALDPTGKWVETYKVLLDGDLRGPRRDDDEVVSSEGCYEISWIWLTPRSALEPGETSSGATAEEFTETMRAEWARSKARAERWEEEEQLLLEEMRRVLTFFEWKSRWWQSQGKAREDVSPRFRRGLAVYAAKQAAVYERLAARTASYWINYLKALGPLPSWIQPYQAFARKVRPRWTVLTTNDVEQDGESSDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6J4</accession>
    <name>A0A2G8S6J4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6J4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6J4"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000090">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-17 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="180" mass="20091" checksum="BC8EDF69A77B1EE7" modified="2018-01-31" version="1">MSTNCRRRLIRDFKRLSTDPPGGISGSPCPDNIMLWNAVIFGPGGANRRVVDGIADTPFEDGTFKLLLTFDESYPNKPPTVKFLSRMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLHDPNPNSPANAEAAQLYRENMKEYVRRVRATVEESWLDPEEQAAMEQDSSGTVGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6M5</accession>
    <name>A0A2G8S6M5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6M5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="434" mass="46421" checksum="235B46A515FF973C" modified="2018-01-31" version="1">MSSSSNSKKGKATNPQHEIESARERIRNMRHFEPEDNAEVEDHVEWVENMTLAMEGVASAGAPDGEVKAIADDVYLQHAAQLSHLFDNWPEWASPILTGAHERAQAAAAARRVADAEAERERKQAERNARLDAFLAKNKIPRLEGSPSGTADRPATPAIAQPPVASSSATGASSKSGAKRKRDPKSPATTGAKPKKPKEEKEKKDSGPKLATITDPKRMCDLCRKIGVAVCEPLVKGKRCDKCVSDKKGCVHGEEPFGEWYRSLEPVPGERVATPGPIAGPSGTSGTPIAPRSSTARADPETPTPSRTRRALSVELGAPMLNFEPHFPINPTPEPIYEADLVERLRREAREAAESAANADDTNEGAGDNENANDGTGEGMEASGSVGGNEPTNTSEPANATATGSPAGEEEGAGESARKRKGKEKEKEKRKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7J0</accession>
    <name>A0A2G8S7J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7J0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7J0"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="506" mass="55345" checksum="4929F81030D9DAE4" modified="2018-01-31" version="1">MSGPEPGWEQRPGDATNAYTRPLIGSELWYDQSMRLQDGLSQFAIGVQFTTTIHERDIEARVKAALVRLRFECPLVAATIERGTHHPEFRSWVYAPLPSAAAARAWADQTVHYLRTPADPFSFLHSTVETTTLPHVLADGSEQFLRVYLTRPSAALNVYCLAFHTVHSIADAKPALNALSLLLEWMAAPEVRVGDGPGEDLAWGTEQKNLPPGPVTVTGGPREDWGTNGMALIQKFQTVFVEPTPSHGLECDTSGDKPEGSGMAHRLLVRFTVQESAKIGQALKALGFTFSELLDAAGLLAAFAHNPVPAGKVDTALIKGASLITLTDRLPPAVDRRRHLVSCLVFAAYRLPYAPLAALPAGRARLLAALRETKEHYDAWLANPCLPHLVAEFGPYIAPTKVVEAPPPGPYVPMMTNVGRVEDYVAPVWPREGEEGGASGGEKVIRVEDMHMVCRMGRVWVQPTLHSWSIQGRLSVLLEAAGVWDKDVLQDYLNEVVKQISLIFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7W6</accession>
    <name>A0A2G8S7W6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7W6"/>
    <dbReference type="OrthoDB" id="10496354at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="160" mass="17457" checksum="C1F8C1C585484A0B" modified="2018-01-31" version="1">MSSTPPCTVIIHVAGDVSPPTSPTLSSSNLPSLSPKTPARNFLRPPGPRPFYGRRRPSLNDYYPHFRPSWKVADGSDPGSGKLTLVPIDSLDLDPDFAPDQPWHKRWKAKSKAQRKTRGKFSGRVLFCGAVVAIVVLRGLVFLVELACLPLALQSSSQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S821</accession>
    <name>A0A2G8S821_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S821"/>
    <dbReference type="STRING" id="1077348.A0A2G8S821"/>
    <dbReference type="OrthoDB" id="272672at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="38958" checksum="1200F1BFFB094877" modified="2018-01-31" version="1">MTTSTKNIPITVFTGFLGAGKTTLILSLLPRLPKDYKVVLLKNEFGDIEVDSQLTKQSSLAAVSEILNGCMCCVLVGQMKTALLEIREKFRPDRIFIECSGSAFPATLAFQIRELERETNDDLKLDAIITVIDAENFAGYEDTSPTARMQASYTDLILINKWEHASERHLDILIDHLNTLNDTTPKVKCQEKDGVDPSVVMGIDSKLFQNPEERPTDAPHHDEVETVTICQGGQVDHVHHGGCNDGHCGRNHGNDLERPAADASLPLSQECLMESLKMLSKETVWRVKGFVRLESGYHILNWAFGRYELIPTEAVPEDIDRVKLTVMGERGEVKRAARKMAEKLAADVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8S1</accession>
    <name>A0A2G8S8S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_07839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8S1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8S1"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL29928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1065" mass="115321" checksum="11D100FFA4884052" modified="2018-01-31" version="1">MVRDTASAECFRGRALTLVGQVFVNDKKFACESCIKGHRSSGCQHTDRPLFEVKKKGRPVSQCDKCRELRKTKRMHGKCTCSTTPAAGTSAEVKIAGPSGQPESKGKSRRFKPIAPALPNGLKGVLPAPDVGTDGTLNLCRCGGKDATVCTCGHERGPSMSMRQPDNGGLAALAHAALFCCADDLPSTSASTSSMPSNTLKPLSTAAPTHGASRKHTRSSCCSSAANSRPPSPKAKRPKPSASAAAASLAHSHEQHLPHALNCCSISSPSAHMASSSAPPIFPAIHPHSASAPVTENGCCCGVQCACPGCVQHRGEEHAAKDMGDCEDGECRTCVDHDGGIALPEHALAFSQGRYAATSTISNPTSASAFKSAAVPAPPLLSPSSSSGSAHGRPQGASTSTSYIDAFFATAASLPAPPPGRSMGSLDPTSVLVYPRGIFVNGDAGRRSLFGLVEVPKLQCSCPGGLDIMVQPEFKSGSVVKELQDTLRDEVDRMDESALRTLLHEAMKVTASLQYAVNSRRPIFTLPTELFNHIMEDIMPTTVPIGSSKIAQFWRPLFRDSTALIPLSQTCRHFRQISLAHPEWWTTLASQRIRDFSICTANSWPMSFNVVAFPEDATDVFRVFNDSTAARLEEVHAVRCNQAVMLGVRNLFSTDNRAPALKSLTCISTLEDRVHPFTLDPERIWALKHLVLDRAEFWFYGQIPYQIPSITHLILAGSSAIHRNIAQLISSCPNLQTLVLSELFSRADGVVPNTPFPVSNRIRRVVLHDLRHSAIEFYLALIRPRADGRLALQILNEQVHHSQFAYEPLIEQCLAGKATHLRIGVFTDTASFYRFSVTLASRANALRFASTASNLAASRYGRPDLWLARLLHPDVTDSSDVREAWLFNTTAPFTVYLTTFQTAVRSAVSALSALETLTLVTVDHPADGPPGTVLWPDISVVPTTDGSEWGCHRLKTLRMVHYDALPPRAQGDPNVFRFARAGIKLEFTRMLEQLALGGYGYLERLVVQASPRFEIDEGEVGALRAHFKEVVVERILELPRMWLPPVCVGADDGPGGRDAWTTTHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9B2</accession>
    <name>A0A2G8S9B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9B2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9B2"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="96" mass="9818" checksum="DBCEDA6EA54085C5" modified="2018-01-31" version="1">MSPMSGAGANLSQLDGLELGLVFADLHETGKLGNNDAVAALVAAFEESMCTLAGRVVSVANGNLATCVGPHAAEVTIARFGDLAIRNTQQLFQGKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA66</accession>
    <name>A0A2G8SA66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA66"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="104" mass="11048" checksum="3EB56874A8FBDCC2" modified="2018-01-31" version="1">MAIDVDTPGGLCVELVIPVLWAPGLNRGGQAELRSASKADTVTAQASLLPSVCFKKEADYGIMKNSSCKKRSEKKTRSGSIRLPTVIVPPSRDRHSAMKAPLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAG0</accession>
    <name>A0A2G8SAG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAG0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAG0"/>
    <dbReference type="OrthoDB" id="368909at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="117" mass="12673" checksum="E9F17ED53BEDAD5E" modified="2018-01-31" version="1">MSSPPVATAALPARSTPPTENVEQLKALLRKTLRVSVTDGRVFLGTFAGTDKQLNILLINTDEYRLGADAGADGLDGRYVGQVMIPWRLVVRVESHAEGDGTRNSGYFDSDEDSMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAI5</accession>
    <name>A0A2G8SAI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAI5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAI5"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="801"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="969" mass="108813" checksum="C4DD2BBCD1D129EF" modified="2018-01-31" version="1">MSVSGTTVPQVEEGKLLSESLSTVKIQVQQMKRHLELDQLMDALKSASLMLAELRTSSLSPKQYYELYMAVFDALRHLSNYLYDAHTQSRHHLADLYELVQYAGNIVPRLYLMITVGSVYMSIPDAPVKEVMKDMLEMSRGVLHPIRGLFLRHYLSGQTRDHLPIGDDAGPKGNLQDSMNFVLTNFIEMNKLWVRLQHQGHSRDREKREMERKELRILVGTNLVRLSQLEGVDLEMYQKQILPSILQQIVVCKDVIAQEYLMEVVIQVFTDEFHLYTLGPFLSATAQLHPKVNIKQIVIALIDRLAAYAAREAESEDPEETKRQEEAAARRLAEKVKQARGIRQNGLTPSSPVTESSSTLHNEWGSPPTSPVVDEKPEEPTAPATNGNGTVEGETEKDGKGKEKVAEAEQVKKFRGVPENVKLFEVFWHQVVELIKARPDLSIQDITALLVSLTNLSLSCYPDRLEYVDQILGFAAEKIKEFTDSPDLHHPQTTANLSALLNAPINSYQSVLTLLALQQYSALLAQQPYSTRRTLAHSLVSSVLKNETIIETPEDVNGILEFCHVLIRDQSDATGPSHSQQLSGKDPRRGPYHHERDELAEEQGWVARMVHLFRSDNLNVQFEILQTARRHFEKGGDRMRFTYPALITSAIKLCRRYKNREHLEDEWQSKVSAILKFVRQLTSILSTTVDAPSISLRLSLLSAQIADECGFENLTYDMYVDAFTVYEDSISESRAQLQAITLIIGTLQGARVFSEDNYDTLITKAALHGAKLLKKPHQASAVNLASHLWWQEVPPEEEVAEGEKESSEKKNGAKEEAEKQAYPLQDSKRVLECLQKALRIANSATEEIITIQLYCDTLDQYLYYLDRGAPAVTPKFVNSLVELITSSIDNIASPDVHPAQRAPPGLLDGVQTPEMITRHFRNTLMYIQTKKAAAAAAAEAPGVTPGAAESRWDDVDIVGALLKMGIPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAL9</accession>
    <name>A0A2G8SAL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_06975</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAL9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAL9"/>
    <dbReference type="OrthoDB" id="5245018at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="132"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="663"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL30807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="953" mass="109785" checksum="EFF281A14A89CDAF" modified="2018-01-31" version="1">MVEEEEEDKPPPPGFLPEWDGTEESLLDTLATGRTLRNAPKLFVSATYTYSQQLAEQEYQKKEIRPVEEIVPKQYHKYLRMFSKEASERLPDHGPYDHAIELVPDARMFHSKVYPLSPSEQVELDKFINENLAKGYIQESKLPMSSPFFFVKKKDGSLRPVQDYQQLNDITIKNRYLLPLVSDLMDRLKKAKYFTKLDICWGYNNVQIKTGDEWKAAFVTNQGLFELNVMFFGLANSPSTFSALMNDIFKDLIILGKVTIYLDDILIFTNNIKEHRTLVREVLKHLAERDLFCKPEKCEFEQPKVEYLGVLVSENRVEMDPVKVKGIAAWPVPQNASDVRKFRGFANFYRCFIKDFSAVCKPLDRLTGNAPWKWEAEEQEAFDELKRRFTESPVLSMYDPDCKTRIEVDASGYATGAVLSQEGEDGKWHPVAFHSESMSDAERNYEIYDKEMLAIIRALQAWRHYLEGLPSVFEIQSDHKNLEYWKTAQNLTRRQAQWALYLSRFEFVILHKPGTSNGRADALSRRPDHQTDDADDNLDRVLLQPDRFRVLAAKRGHMSVVPEKALLRRIRECGEREQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLTPWAGKDGGVGNANYWWPGMVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNALQLIADRHGKIIHLIPCTEEINAEGTADNFIREWFRLHGLPRKIISDRGPQFSSKLFRAVLKGLGIESAMSTAYHPQTDGQSERWNQEIEAYLRMYCSRCHDDWVKWLPIAEFTCNSHVHLSTGYSPFYLMYGFEPQFHIPMLEDATSALTLAAERMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGHHPPEPALIEVEGEEEYKVEEVLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBW1</accession>
    <name>A0A2G8SBW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBW1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBW1"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="190"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="470" mass="52543" checksum="8B88FF560F7F2E87" modified="2018-01-31" version="1">MGDNITSSDSKSIIPPYAQPREQYSTSIKLNKTLVLCFDGTGDQFDSDNSNVVEFFSLLSRDNHDEQMVYYQAMSKVLDAMVAWNLDAHVISGYKFLMQNCEIGLSSISRSKITPSLSLFPFLGFHPFVDKEGDKISLFGFSRGAYTARALAGMLHKVGLLPPDNYQQVPFAYKMYKRTDSLGWEQSKRDTVCSVGLIHRQLPFTVSNTAIRVFRHALSLDERRAKFKANHYNRADLGPTDETQKSELTAAAGTTSVATPDTHAVSAMEGGGIGQRPATPANTENSGDLLSSKSRGKQQAELNEKNFNATQKRLVQETDVKEVWFAGCHCDVGGGSVLDNVENSLARISLRWMIREVFRTNTGIHFSSKLLKSIGLDPASLWPEAKVADEPPPENPHTSKTLPFTPNLTMEEIEEEVKDAMCPIYDQLRIKPGWWLLEVLPSKQHRNEQWWKVLNVALVRVHGFGPEVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC43</accession>
    <name>A0A2G8SC43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_05865</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SC43"/>
    <dbReference type="OrthoDB" id="8061355at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF36">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1014"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1054"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1091"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1157"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1207"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="459"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="780"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL31168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1596" mass="174017" checksum="572957F0DE30F69F" modified="2018-01-31" version="1">MAGLFFRQFWALFRKNWIVMSKHPWLNVIRCFIMPIAYGVFLAVAQIFLNKPNNYGLGTSVPVPRLADVFDGSLALVWADGTNGTGSNPSAHDIISHITSGFSSKQLSAVRQLDSPADIPSACPQNFNLFSECFAAVAFNSLPGPNGSLPLNYTLRADGGLFHIDVTKHNSDYEKRLLPLQWAVDSAIIELQSGVAPQTPLEWPFTQETNDEQFTEIRLSYIRGLRTLLVLALFICYVGISYQLPGSFGGERANLLTAHLKVMGLLDSARIFISLAYLPAWIIVSIIWHFRIFTATNVGIIIVVHLLLGLTLASWSFFVATPFGKSPQLAAVASTFLAIVFAILALVFSRASTGAAFIFTIIFPPGFYIFAIRAICGWEVHQIATNVLQPDPDNALRLLPLIIAAIINVFLWPYLAVLWESRLYDARNPSTRSWLSRIFKRKHSGATDGVPPIGPGTAISIRNLGKDFKPPFFKGDKDLVTAVSDLSLEIPKFGIYVLLGSNGAGKSTTMSILAGLLGRTRGTVTFEGGVERPPRGTIGIVPQKNVLFPELTCYQTLRVWKAVKRSNGREDDDIEQLLRDCDLGKKIHYNANALSGGQKRKLQLAIGLIGGSKIILVDEVLKGIVWVALWRTLSAVRNDRTVVFTTHFLDEADLLADTIAVLAAPGKLVAHGTPVALKSTLGEGYTVNVSFTPEEKVKSVRTAEGELLEQIHSIARLAYISSSAPNEVSYHLKLKDPSVVRRVLELVENNRERHGVANYSVAGTSIEDIFLGLMHDSARPEDAKDKEVENGQSSATPSLVHVPPPAPALQLTNGRRRSPFGQALTIFHKRVLIARRSWLTPTLAVLVAVAGSCIPIFFLSNRTNQTCETHFRTVAQTPLYLPASPLLLAVQMAEGSPLLESPPNIIQTLGSPTQFLTTQNIPDNATFVQTIDQNFRNLSFGGVSIDQQSGRSLFAWEATPPGLTGLVMLNLVSNLVYNTALNSTNHAAASPSIILANYQMFPGIAAGTLVALKWVAFFGAAMAVYPAFFSLYVAKERRSAVQAMQLSNGLSDPVGLWLGHLLFDSMFAIVVASLIVIVFAAASNQFHGLGFFWVVLVLYGIVGALFSYCVSLIVASPLAAFALSAGYQVIMFVLYLAAYLLTLTYAKTSDAGTDLTIIHFTMSLLAPVASALRASFVSVNLFSLLCDGSSPVTASSLGDISRYGGPILYLFLYAFVLFGILVWVDSGSIIVRKFSQFRKNPIFGMGSGTTTPLDEKTDMKDVDDEAVKVNASDDALRVMNVVKAFDSATNRVVDNVSFGVSQDTIFALLGPNGAGKTTTFNVIRGDVIPDEGDVLIKGVSMVHHPRSARLSLGVCPQFTAIDSQLTVREHLLIYGRLKGLYRGEELRTNVESLMRATSLHMYADRLASKLSGGNQRKLSLAIALIGNPSVILIDEFSTGIDAKMKRDMWGTLRNVAVGKAIVITTHSMEEASALANKVGILAKKMLAVGTTDSLVERYATYEVHFSCRTREEVVLAQEAMSHIPGARMADDVATRFEVPIGTGMSLAQLFAVLSGGGFAEYTVERAGLESVFLKVIRENNVLEEDRDKKRRWWRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCP0</accession>
    <name>A0A2G8SCP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCP0"/>
    <dbReference type="SMR" id="A0A2G8SCP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCP0"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="207"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="36563" checksum="BD2B8E1240CFBC17" modified="2018-01-31" version="1">MDQHQQQSQPMHDDSSQNFVASQYAMYSSSEDDTAGYLVYPQMQQTGYPPVVHNPGAPPRQMSDSDLQQAMQYHRSIQMMPPQSQHFGPAAPGVYTASPPHGVMPLSASPPPQSPNMYDPLSPPMSGSDTSADGIYHSRNSSATGSPASSRGTSLVHRHPLRYDPTPSPTSSVGRRSRGHSISDDDDRNPMGGVAMAESLANTRKEATRRQRIEAEQRRRDELRDGYARLKDVLPVSNQKSSKVSLLERATNHIVNLEKTNRQLQQRLAALEAEVARLRALNEKISLGVNNTPSPGQVSMDSRPLSPPPEGTQSQSSNIDQPLAESSPSASENGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD68</accession>
    <name>A0A2G8SD68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD68"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD68"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="13"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="199" mass="22316" checksum="44182FEE828FB67C" modified="2018-01-31" version="1">MSHSRYPIPPPEKYLGLSTTSVGCGPGGGTPMIARVALVDYRGQVVFSVYVLPTNPVTDYRTSSTGIRPEDLQPGSAMAWKDVQQRVAQLIRDKIIVGHTLWQDLSVLGIRHAAVATRDVALYQPFRNALRSTNHVIGLPTLMWQLMRRRVQETHVCPLENARAALDLYRSHSDEWESTIAKGQWPSFLPPSTFSRCYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDD0</accession>
    <name>A0A2G8SDD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDD0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="15897" checksum="7C02B52DF7469D4E" modified="2018-01-31" version="1">MSAGASPYWERARRRSAATHTKPLPRANATCWWNRSLLSTRTPRNRWCVAGLMVVVPSARSGPRASVTRRDMLRRPNLSREKWELCDADHSRAPPGRSKKSQSLLWVSANVRPTVIRATSSMEPTAISPFFWQALLISGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE82</accession>
    <name>A0A2G8SE82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tubulin-tyrosine ligase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE82"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE82"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54774" checksum="456531DB43A9E7D9" modified="2018-01-31" version="1">MADFTAFVSWPSAPLTYRLVLDALGSLTPPPPVQDVSPKDTNGSPHRLLQWATYDELDHDLTFSHDPASKVLSSSYVIRKALIRKHYLSRCIHNYLTKHPDSILRRGVPRTWELELGFADELDELWSDELYDLSKEIEKGDTSKWWILKPGMADRGMGLRLFHTKEDLEAIFQEFEQDESDAEDIDRCDEDARDTAVVTSQLRHFVIQEYLGNPLLLDPAETPLDDAPKPPASSLHGHKFHLRVYCVASGAIKVYVYERILALFSALPYTPPSKSASSIDLATHLTNTSLQTQRGEAGVRLLDELVGCHLLSAAPVPRQRQPARPPYAMGQALEQEAIRAARKQERQYPILTEEDVENLKSQIGAVLAETFKAAIEMSVHFQPLPNAFELYGIDFLVTHDTSPEVPHKLQIKLLEVNSEPAIELTGPRLTWILEDLFKSIAKTCVEPFFSPQGSLTRSDMEVWRTGETRENLRKSLDQQIRSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEN7</accession>
    <name>A0A2G8SEN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEN7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="81" mass="8921" checksum="2E8AD928A9C75677" modified="2018-01-31" version="1">MKLEETSSQREQNMQAALDLQNDQLQANSKLIDIALAQVEVAKEYQTSVQKRLNGLKARLRALEGVRAGLEARLANASGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFJ2</accession>
    <name>A0A2G8SFJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFJ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFJ2"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="188"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="386" mass="43000" checksum="6A68C1771A2CA14F" modified="2018-01-31" version="1">MLASRLGRCARLPPLPTPSRTLPKPKLSHPVARQVRNYAQSPFGGRSRYVRFGASGPEGKEHKPWDWRHWDSRTRLGVAVGVFAGIYYVSHLEKVPETGRWRFMDISPKFEAKLAAAAHQEMLQEFQGKVLPPNHPITRHVRRVTQRILEGSNLGTLDAPDVQRAKGLEDLWSFTERDELPPEVGGAKQWHLFVVADDSTVNAMASYGDIVVFTGILPVAKDEHGLAAILGHEIGHAVARHSSERYSSVKVFIALASLLDFIGIPFSDAITRLMYDLPNSRTQEYEADKIGIRLSSRACFDPEAVPEVFTRLGKLEQSMGGRHIDFLTTHPASDKRSTALREMLPEAYAAQAASPMCGSTTDHMAAFRDSWLGNLDPDKMSEVRWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGK6</accession>
    <name>A0A2G8SGK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGK6"/>
    <dbReference type="OrthoDB" id="2756545at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47179" checksum="3AE6C8A0D8507956" modified="2018-01-31" version="1">MLTAKDPSRFAYFRKLDLPLRLPPDSSYVQRLLTDLLLHPSLSLETVILDCATSLLDRTSPCGLASVRGILWTIQTLRHLVILRVGEASASLIQSLLSKLESITIGVGADAGGRLDVMSILRPFSDTLQTILIKWTPSLLPPFPRTDAGSCYFPLVRTLGIVVSDYSVLKLLASPAFSRAFPAVSHFQLIPADPPTGLYRLYPHRERQVSRLDQIREGNRALRSQRLDTGTRPAPSLPNLKECSGALNDVYASGLDCSLSTLRLWQHLLVRDLDLLCMVLEDTRPQRLCFSTRVDDVRQVLDLLGALRTHVPTHIDMTISVARSSWLARVLKGPDDMPRVNRSFLESSLRYLPTGLVELNIDVSAVIPLGDRSAVRDVLERFTCWTLKAAPGVALTCRLAADEDWKWPDLGQEDDLEHILRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGZ3</accession>
    <name>A0A2G8SGZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGZ3"/>
    <dbReference type="OrthoDB" id="2802907at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="306" mass="33860" checksum="5259B54A0D54C6BA" modified="2018-01-31" version="1">MSDLLIVNQADVSLRSHPLRANSCRANLWLQITTGVLAMMAFGAFSALRAYALSNRNMWLTAVIFLLAIPPSAMAISVRLQRLDVAVPHAFHEVCFPLSILFEHTNRLMITPSSINVVWRVSQFAAELLVISITWWYTYRSYRIRKGIKLGKTISSLLIYNGSLYFLFLATLYILGIIVNTTSILGAVGDATSNLGMFYDPIAAILTCRFMLSLRRFDSTISSPTYFATGSRLRGQAASTMLQFAAPASDTLPAFIASFAHPVYVDSSFADHDALVDDDDRSEWREMDAVARSPDSEGTVLSESGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH16</accession>
    <name>A0A2G8SH16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_04513</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH16"/>
    <dbReference type="STRING" id="1077348.A0A2G8SH16"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000011">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL33064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="143" mass="17081" checksum="618DAEFEF8EEA420" modified="2018-01-31" version="1">MIRFILVQNRQGKTRLSKWYVPYDDDEKVRLRGEVHRLVAPRDQKYQSNFVEFRNHKVIYRRYAGLFFCICVDANDNELAYLEAIHLFVEVLDSFFDNVCELDLVFNFYKVYAILDEVFLAGEIEETSKDVVLARLEQLEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHN5</accession>
    <name>A0A2G8SHN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHN5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHN5"/>
    <dbReference type="OrthoDB" id="2800059at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="39"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="353" mass="39276" checksum="CD988CC594CD6E41" modified="2018-01-31" version="1">MSSESAPSRKRPRVEDGDRERPSNRRKSDPRKDDDVWLSDGSIVVVAADNVAFRVHKSTLSLRSEIFRDLFSLPNADEATAETMDGCPVVRVSDTSSDIRHLLLVLCCGKNYYHDGDALIAVPFETLASLVRMAHKYAVQDVLDHALSRLKKFYTNDLAAWQDPDARARYVAAKDQHALTVVQLARLTNTPPLLPTAFLLCTKLLATLARMKQGVPVALGVSSLPVPDQLTIISAREYLLHMCAERTLHLLAGAPCTACTTLAVCSLTREAPLSSIRDGHAFPAPPLFRRDVLQPMAATLWGDRWHMFCDNCREALTEADGKESKWVWRNLPRIFGVKLDRESWPSLPADHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHS8</accession>
    <name>A0A2G8SHS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHS8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHS8"/>
    <dbReference type="OrthoDB" id="2802139at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="75895" checksum="42D1D5278E95A2DC" modified="2018-01-31" version="1">MSGSDYYEHLTHLTDSVGINPPPDQRLALELMVKQWRRLKSLQHAGTFHGGDQSISPNWGVTACPACPRPEDMPAKSASSRTPKRGNKDTAYHHRSHTEISMAFEGEADEQHDSGVYVDVVACPHGLKRACVVERASEWYVITSSLLSAALTLSSCNSHIDSSLPHEPLVAPGHDPVCVSKTGHNIQHPSILTKAADANTHCNELDEIFGTWNRRRIVALPGALLRRAKEILPQHVHCWQMYDALDLCIPEEFASAWSKMMVNWREDLTESEVRQELKQMDAIAFEEGRRRKTGFTTSQIVTMGLDLEEEQRSLCAEIAASPPTMTDVLKADLRERQNVLRSRIEAWHDAEQVLIPALASLRSGAANDLPAHAITLLLPSFIYSSIAFTQDFLDCEWRLREAQAYDALAAIRGYLQVIAYVRHIAHGMREDARAQIEVVLVFASRSIDELVVRYRDAQAALANLAEPLGTNGRQFLRELSDSDVRFVTERDARQRPSWIWEFGGTAFLKDEDLFDISRNKNLQLGKFFFSACSQHCLILRALALRTMWCRARARAFDISAERDLLLEEMDRAAAFHDAQSKWWEGWVNLAFPEHPDDSEFLEGVNAYAYRQASIRRAQEVHCSSLARVIRYWFSGKKLPDHTSLGRRPLSQVSLTSGGSSLESVQLENVGDDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIH1</accession>
    <name>A0A2G8SIH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_04140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIH1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIH1"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="502" mass="57061" checksum="6918E6E2933E1B12" modified="2018-01-31" version="1">MSADPQTVFYASLAVFVTWYLIKWRADPLWNIPTVGGPSAPILSYWTAMKTLKDSKGVLQEGYNKHYNSAFKIALLDQWVVVLTGKRLIEDLRKRPDSELSLSESIEDIQQIRFTVGREMLDDPYHVNIVRDKLTRQIPAVLPDVIDELAMVLPEYIPTDSADDWVEVGVWRSMLNIIARLSNRVFVGPPLCRDMEYLQLAIDFALDLNSDGALINYLPMFIKPLVGHYMSNVRKSVRRAIPFFSPVIKERRARMKEYGDDWSDKPNDALQWVLDTAVPKGYDDVSVVERLLFINSGAIHTTSNSLTHALYDLASMSEYIEPLRQEIEPIITEEGWSKTAITKMSKLDSFLKESTRIHGIILTSLTRKACKDVTLIDGTVIPKGTFVAAPQSATHLNEDYYPDASTFDPFRFSRAREEEGQALKHQFVNTSTEFIAFGHGKHACPGRFFAVNELKIVVAYILLHYDLKLAGDGTRPKNIYLARNILPDPSGKVLFRKRKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ24</accession>
    <name>A0A2G8SJ24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ24"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="13203" checksum="4AF700760788CC9E" modified="2018-01-31" version="1">MSLAAFMTTTITAARIYRKMLHRLDSCPVNLCPIQVYRWLEQGALFVAGKLGLKPKPCLIASNQAHPSNGSPPLGSQRPSQSLTLSMFSARQRQADNRICVPAHSRSTYAHSSLYETQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJT3</accession>
    <name>A0A2G8SJT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJT3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJT3"/>
    <dbReference type="OrthoDB" id="3251181at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="563" mass="61021" checksum="4D6C41EEBFCCB579" modified="2018-01-31" version="1">MSTEASINSSKYSVPRLATDGSNWVTYQARMQAIQAAKGHMPHIRGTARKPPLPPPLERANPHISGSTAMTTSATATTTTPSSSPKTTPAATTTTKPPSDVYSHLTDDEYTELVEKMDAKYCTWEAKEADARALIYETLGDDLFIEVQSQPTAKHLWEAVVASCENKSLMYANAICTRIQNLRCPESGDVRAHLALLLRERQNLAAVGSCLGEDEFAAIITNSLPESYHPRIQSILDISSLSGHTIPIDFLIGKLNEEYDRRRINKANGSALAAAAAARSNAGSGGRVPVECYNCHRFGHIARNCREKGGGREGQWPKPRDNNSGNGSANANAATEKGFLALGNTVTSALVAAPGSYVDVFDSGASVHILPYRERFTSFRELQPARSITAANGEQFLATGEGEVELRVPNGDKTQLLKLRNVLYSPSVAFALVSIKKADEGGYTTIFEHGECRIVERASDLDVARVPLTDGLYQVVSRYIEVAAAVVSSTRPGSNRRTLEITQAEFHRCLVHYSYKAARSLILNGHATGVEFTDPAPYDAQCDITCGFHCCITIDHYSGPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJT7</accession>
    <name>A0A2G8SJT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJT7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJT7"/>
    <dbReference type="OrthoDB" id="2801180at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="68366" checksum="D349670CC00C68BF" modified="2018-01-31" version="1">MSAMSTPQSGKARVLSCPAVLTEIFNHLEPGRCTPKERRTTSTIEHLSACRRALLMSALTCRTLSDIALDVLWQVLNDIRPLLRLLPTYERPLPVIVLRSQIMPVTWARFQSYAARVREVGYSPKIKQVHPSVWTFLAVKYEGSPLLPRLCRLDAPDLSPDNLSPLLLLLSPSLRSLSLSFGEKSGSDVAAPEVIAVALQHATQAAPRVESFHISGHNSFTRKHLSILQRFAELTELSLGATFLFDQTMIRQLSTTTFLRTLAITIGQVQPSTLELLANNFQSLNRLTLRGDLNNLVNFILAFSLPHLDSLTLHMHDCNDPKAFSPRFASMCQHLGLPKSLKHIDLRFCSGMLVQRQETLSQYLEPLLLFPKVERCNLIFYNTAPSVCDEDLIRLGDAWPNLQHLNFEEFTTDNERYGRFSKYGHLWCNAPDIQHPTMVGLTELARRCPTLRYLHLVTADVGTLPAVDAVSTLDHPLEKMLFDHVHNAASSGEKRCAAAEVLDAAFPKLSISRSAGHRLLLGRPETRHQWRRILMLMRIMRRQRKHPKSDADEGAGQSLADLNVDRELTDSDPEEDAFEEDGAMDLDSDSAANSEGSQESDGSEEVDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK91</accession>
    <name>A0A2G8SK91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal ligninase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK91"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK91"/>
    <dbReference type="OrthoDB" id="2755629at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal ligninase C-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="101" mass="10705" checksum="2105B097B0D8E2A5" modified="2018-01-31" version="1">MEVPRDNRTACEWQSFITDQTSMVSKFTAAMAKMAVLGQDPKTLIDCSEVIPTPAVATSQTAHLPAGKNLTDIEASCNTTPFPTISADPGPETSIPPVPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKG0</accession>
    <name>A0A2G8SKG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_03757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKG0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKG0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL34048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="553" mass="61969" checksum="86002BCB317F66AA" modified="2018-01-31" version="1">MISTTDLTGSTVYLTGAFVALGLLLLVVRRIFDRKGIKHIPGPPSPSLLLGHDYAYACQEEACSLELQWMREYGTTWRTCGALGNDVLMTVDPKAIQHIMQKSSYNYTKKIGLTHSAWLLLGPGIVTVVGKDHQRHRKIMNPAFSAAHLRSFLPLFQRIAGKLSDRWKGELMATGESSTLLNRWLSRATLDIIGEAAFNYDYNALDGGERSAISKGYEDIFKDTEYLPGKATVLFRAAWDYIPTPLLKLIRYIPVHPWTRIRNLNALFEEYGRQIIREQGPNTDTEKKSTSKDIMSILIKANASEDPKTRLDDEELIAEMFTLTLAGHETTSGTLTFLFWELSKHPEYQARMRDEIRSVRARVTARGGSEFTIEDLESLTLTMNAIKETLRFHPIVVALQRVAEIDDVLPLAYPIASTSGEVVTEIPVRAGQLIHMSFAGYQRLPDVWGEDAHVWNPDRFSRIETGKQTTNVGVFANLNVAAAGVRACIGWRFSVIEMQAFIAELVENFQFDPPTEEVEIQRALAGFLFGMFPVVKGQAERGGAMPLRISLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL41</accession>
    <name>A0A2G8SL41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL41"/>
    <dbReference type="STRING" id="1077348.A0A2G8SL41"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="193" mass="22405" checksum="20FB47D31F39A82D" modified="2018-01-31" version="1">MLAKRTVETSLIALAIVALGLNAIFKFAARSVIDRAQDARRDNGGIWNVERKEVALQFDSWTRYQLDSSQQWAPLFPEGGIIHLGPTRTPYTVSMMHQLRCLDVIRDQLNRPKSERDAEPTRHCLNYVRQMATCRGDLQFDPIQYPHKVNALHPHAVRRCRDWRAVYDAVWKNQQEHRDWLKKSRASNEVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLY5</accession>
    <name>A0A2G8SLY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLY5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="117" mass="12467" checksum="FF86B76482C9D279" modified="2018-01-31" version="1">MGTVSAIQCMVAHVRAMGKPFFSAGINPPLSSHTTFNGVQMVIRSNGFSSGTLQPSLHFVVQLEGYQPPGIPKYDIWINNPKEDDAAANQAAVAAGLEILITQGTWNTRSAVSIEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN23</accession>
    <name>A0A2G8SN23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN23"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN23"/>
    <dbReference type="OrthoDB" id="2753926at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53552" checksum="2D61A61EFA48FFB7" modified="2018-01-31" version="1">MYVEEDGIILSQWEPLALIDAPEKYEDRVEELHVVTADGWKHGILPPSLLSPRLNSLKRLIIRGMHFGTFATSSWQWHGLQSLFQGQTLPLRALAIIDAPFLPSNPAPALTRLVLFYDMKREMRETWSARDLLRFLSAIASTLEEAVICGIPCLGTREPDGPVYLPRVRKLSLRCWSYLNPGSPRVPLPLLPFIVTPQNCYLRLDANSIAELWVLADHLHKRQQQWDVPTSNVHCVWASSLYTMSSLQATFPGPAPDGGGGVRVDFPVLLNRRAENTFSGALGALLQTPPFAAAQALWVSGSGVDDAYEPELTRSMGRLRGIRALYVATDLLSGSEPSRFIESLAGAAPTRRTPVPLPPFPVLETLYVTVYDRPGVEKLAEMLRRRAAQGCKLSHLLVGRAEVGDEDDEDDEGEGAAMLVFGGFEELCAALRGAVGKVTVLSEDGYEKHYALRTVLPPICTRPGGGLIWPPWTENETTFALMHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN36</accession>
    <name>A0A2G8SN36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN36"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN36"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="4">
        <location>
            <begin position="70"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="223" mass="24358" checksum="3FB11E4FFDE60828" modified="2018-01-31" version="1">MLASMRQAAARVAFPRVAGVRTLTTGSLPPAAANQVPTISTAGPVTTPFMSGPPSASSSLSNAAASMQAPIIHIPPAEDPLLHLFTSLVMFDGKRQAASRVVTRMLLHIHAFTKAPPLPILRQAIDIAAPLLRCRQFKRAAKQYVFPMPLSERQRTTTAIRWIWEAAKTRGGRHVEERLAREIIAIVKGESEVLKKKSDVHKLAVLHRGNIVKPPRVPRSNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN53</accession>
    <name>A0A2G8SN53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN53"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN53"/>
    <dbReference type="OrthoDB" id="3248529at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113696" checksum="DFE15DB8A896FAEC" modified="2018-01-31" version="1">MSDAPDSAPKQKAQGTAKQAAASKVRKQGESASSGSANQQQGKQPESSTAGSSTQQPAGPTPSGSSTQQSSQGREPQSGGGADTESHAGPSGRLQADLDLTRTCEDLVDSFRRGQAQKGATLLALAAALRVGTHDQGVDGDAVETAFESYCAQVDEIAKYHDENRPNDSGEGTQPRGDTPEEDRGRPETLSKSKGKRRAHRSASRSPSKSRSRSRSTTRSSDEDEQPAKRQKQDPSLFAWASANSVAESSLRPELQETLKLLRNHEKDLKFAKASLRNLVGVPEFPEAEWTNVLLGKPVNLNHVLSGQYTLEQDEKHVEKFGLVELSYRTATPSKIVKNAGDWIIAWQRTTAATLYAFPHRRAELDGYYLHIFGLFSAIHASHHNCILDYDRRVRKRVAAMRTLLLTDTHEFADLRDQFINIFGASTSHASEESKKRAGSNRKPHDEEACYVPDSILNDPVINDTLRSRPDLFKIVTPIKIDVFENLLSDHPNPAFIASVVKGLREGFWPFADGRPDQYPDTWDEARPPLIDEHARQFLRDQRDEEIALGRYSPAFGSDLLPGMFSMPIHVVSKPHSDKLRLINNLSAGKYSLNGMIRPESIKGAVLDGLPALGHEYRKLKAAHPGEDIIFWKSDVSQAYHRMPMSPYWQIFQVVTIDGQRHVDRCNTFGGRASLRVWLAFYCCVAWIAVVKRRITSLVSYVDDNAGVQLCRLVQWYIAYGMYVPKDQCTLLILWDDLGLRHDRPKQIHGLREDYVGFEVDTTTSHATLPPDARHKLLDALEAFCAPTHGRRRTLAEFQSLAGYVNWALNVFPLLCPALSSLYAKIANKTRRFATIHVNNAIRQELSWMATHVRALPGIRILSTNVWSPADLSPGSLDDEFVMTDASGRGLGLYFPWQHLGFHATLPQDAPTGAIFFFEALAICAAIHKIPIWHRAGRIIRRIGILSNNTNAVSIFQSLRAEPLYNPILISAIDVLLTHGVEHRVDHVPGEYNVVADALSRGNLDVARAIDPLITILPFQPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN61</accession>
    <name>A0A2G8SN61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02996</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN61"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN61"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="841" mass="93183" checksum="9CF361E7275EB665" modified="2018-01-31" version="1">MFDESIAWLDSILDVQDTSNGFLSVAPSSEHLLSPQGSSFAYPSPLSEDQHSPYRLTRSVDSPSSSTTSQSQSPSPQPPAADSSLGTPSSAPAPATKPPRRRIRPKIALDPNQPLTARGKQRARVYVACDQCRIRKTRCDGAKPPKRRGQDKVPGTRVRTSTHHKSKRRKTSSGTDDDDSGSESSSPGSPSPPCESTCGQRQPDPQLHATYDNFPGLYSDGDGDGESDEYDPFPLVDLDGPNAETEYSLGRYAFQKEPAIPARPSIEFTRDTWWDALLTFYSTDLGTIEAISLSADQRSDIVVHIISDLRALFHSSVYWVSFIHLPRFFDRLLNPKSRATMQPSFIMSALAIGLFTQSSEAERGAAGRVKALKLVELAHSSLQASMASGWVDVELIQAAWLMTYFELQSHPKKSVERGRSAMLLLDSLIRLFSLTTLDSDVKRAYTTNRPSMVSQNAAQYDPPMNDMAPMGGLSTTNHIDILLSQAGLQPNPPPSAASHVPVEPLIPDNMTLGPATASSPLSGCTCGSLTLEKNWPGVNAIAPTWAGTLVWPENLPDGEFKKEECRRLVWASVMITASLNAYSSTNDIVGDIHKNQLWIKNPENFALLFPAESLALHGTSVHANNLWTLHLRSMLLLDSCVCKRGDVHLTNGERAQFAMQAWLEIDAIEHALGQHTCELERNFGFQAREMLFSARMCVSHEFQRYIPCVTTSGSMLFYRDKAEEWLTHRMQFGNRLWQDMQLGIQSLLLDFRKPMLIYWFMSHVIKGLVLWEADPTLAVALETGKTFAVRVEHLMLYWPSEAQRREWEGIRMQLVQSCLKAGVPLPSVSIPGAIPRMNAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNF8</accession>
    <name>A0A2G8SNF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNF8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="15345" checksum="452F24C8EFD5A391" modified="2018-01-31" version="1">MVAKGKLFSDLAHLAHLPATASQVPATSRFSPSSASRVSPIPYTIAQLKFPSPSLLRPRSPSLMTLRHLPRSTLHCAQGAQLPRADLLRDQASGLHYALAWLVQVLPRPPLTLRPLSSLYAHVAAGSSRKHFGILRSIPSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNS0</accession>
    <name>A0A2G8SNS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNS0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNS0"/>
    <dbReference type="OrthoDB" id="9999611at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10821" checksum="BCA4EA39AA36D602" modified="2018-01-31" version="1">MSSNSGEPSKATGQLHSLKGTAVEAVGNLTGSDSWTQSGKEEHAQGEAEYKAAQAKGYTEGTMDRLGGKKDAVVGAVTGDREQEVSGNVRHDKGQAQQDINKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNV2</accession>
    <name>A0A2G8SNV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02157</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNV2"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="206"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="357"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL35430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="666" mass="73304" checksum="C0F75C2F39706789" modified="2018-01-31" version="1">MLRALPVSRAVGAPSGRAAVRVVRRRFATEPPPAPPKKKKSVVRRLVFYTAAGATTFYVGSAFVSFQVPQYRQIFVEQVPLGASVIQYAEDHEWDNLTVNDVIKGGQNLFVVSQELFNKVVAMFSGDNVKDTLEKTKEQARHAIEQGKDRVKSAASRAATKVEKSESKVYDKGAKAAAIAKHQSVQFSEGVEELVRKAEAALAGRPIPESTTIPAEPVVSPISTVPPPEEEASPKAAGNVYDAPLPVGFEPPPGYSRPKPPKKAAPTSAKESAKPGEPVLPAPSPLPLLAPAVSEFSASEPVIAQLATVIDDLASYLNTNPTAAEKARDILDTAKVDLTQLAGRIEEIKATEAKKLEASLDEQAREAMQSLMELEMQAQDKLDSQEESFRRFFEQERAKMIHEYRQRLEHELQTQSEIINERLKKEVVAQGIELQRRWIREIKMRVEQERGGRLAKLDEIATNLKRLERVALDNAGYLDENIRVHALWSALRAVSHVVDAPERRPFREELRALRRVTAAREDPIVSAALQSLETSDVPDVGVEPLADLTTWFTASVAPRVSSVALVPDQDAGVLSYLASNLFSSFRFQRHGLVPGSDVLSVLARAEYHLNEKDLDSAARELNQLNGPARLLLSDWLDAARKRLEVLQALQVVEAEATLASLLVVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNZ2</accession>
    <name>A0A2G8SNZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02209</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNZ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNZ2"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="193" mass="22373" checksum="6A3AD76BAFFBC6C5" modified="2018-01-31" version="1">MDSKSKTAILLLAFSLSNLLYILWFWRHLSRYEVGLPEAFSYRAHDYPEYLPVTLEDVFVTIEETSHYLPLGEESEAALVSMVPAGSGYIRLGPEDRTFVVTMFHELHCLRMMNRAFSKSPTVTLDHLKHCLNYIRQGILCSPDLTLEPGDFEERDFEVERTSGTHVCKNWDAIYNVMEEHYYSWSNRTGYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPB1</accession>
    <name>A0A2G8SPB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPB1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPB1"/>
    <dbReference type="OrthoDB" id="548949at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="696" mass="77562" checksum="8E8DD581CF6E0474" modified="2018-01-31" version="1">MATIQGPWTNHLHGLSQHFDEMVEIDGFGERDPGDKKFTKILHDACHVVWDAEKRSFPDLSGIVEKAHTLVEKAFKYGFADLAMVHPHCYAHSKHAPVVQDSLQMTGSDIIEAVMDFWTNFDQSGEAPPKLPDFAKTDPWTKTRQPHPRTTRLARFRDGITLPTSAATPRAHLIYQARATVRAEYMKPPAAMAISADGEHLFMASSTGYKSRDPSLKHYNLDEDPELDWGGRQDPGLSNTPDYLALDDERQLVFLADHDRIKSFRWGVPPDESSADAARGERKSKSKPSKRLPNVHTLNSEREYTGPLAVLPGGRIVRAGKGAAAVWNTDQLATHLDTPAGTLLGAGRLNTDNSWREADCAGIEHSAGLPAHAVVRFADEPGFQPAAWHVHRPTGWLLCGERSCDTDGFACVALDLEHGGRRAARFLGHGHDAEKFATSAGEPSVFWTAGGDGFARMFDVRRPLPVLTFDTGGQSEGCADVVFVHPDGIPTLFTGGERTQQIKMWDIRARACVYELSTGNNGVTSMLWDDKHTTLLAASERGYPKYRKARIPRWATWWAIEKSMKEYEKLSQEPGVSTDEERTAGEAASATNVPADEDVKMEDSETIEDNESDWEDEESEDEDSEDGTEDSKEDDYENPKDIDEEYSSDKRWPQQAYHDERFFGYAFDADGSALLRYQFTDEPDWDMPASASRSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPV5</accession>
    <name>A0A2G8SPV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPV5"/>
    <dbReference type="OrthoDB" id="2753918at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="346" mass="36777" checksum="C8D9E8EC17B48668" modified="2018-01-31" version="1">MLPSQVSEKLNRNQPPLKSMNSAPDALKLVYKGLVLRRKDLSNEPTHPSCTVVCITIAYSQASITMDANTSTTLAPSASTLAGPVSSTATTPTDSSKTKSPVPHRPNKAELQSRLFHAHVRAQVRRLRQSMLDQDLPLYSKPQRAHRPSAAAIPRNLPIIITSSGFAILAPTAVRPAHPSTPDAPKLGPLPTPPATPEPETRPLLPTRRSRAAPLERITGSLALNEFGDDPILTPNHVFPDNLRRTPGAAVAKAGKTGSEVDYFCLPPGLFETPVVGQSTSGSTSISASTSTSTPPPTTPVGLGITVPTDDGWRSPSRPRAVVGLGITGFDFEEDGRIERSIPTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQY6</accession>
    <name>A0A2G8SQY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQY6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQY6"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013546749" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="61"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="482"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="508" mass="54247" checksum="9509110883124595" modified="2018-01-31" version="1">MKFLAPSLLLYLSCLLDEFPIAQAIRLPLRARMGGFGDGGLARRASLTGTPDLTNQGNMQYQTNITLNGQAFQVLVDTGSSDLYVVGSVNGAKDTGKTGSVTYAIGSTKGPIKTATVEFEGFKVADQVFIEQPADSTHSAGAGIVGLGPGGASNIQEIIASSAGDPILDRIFRQNTSTPNYITILLGRADDPTDTFPGDLTIGEVVSPFNNITSQPKLPVTQMSNRNGQHWTAMLDKNGIIGPDGNRMNTTKHATGNKLTVMFDSGFTFPQVSKNIANQIYGRVPGAIFTNVTGGTAPMWTLPCSTELNVTFIFANVSIPIHPLDTVTSALEGPPDDTGAPTCVGAFQPITTDIEGFDIILGMSFLRNAYMLINFGDFVDGALTKVGDPYIQLLPLTDPQEGHSDFVKIRMDGIDKSADLHLLPALPNNGEDGKNDKTQEDTLHKYLPYIIAGSIAAGVVILALIVVASYRSSAKRRYRRLHDPAPAGLPSHATNGAPSQDYQPTRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR32</accession>
    <name>A0A2G8SR32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR32"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR32"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553560" description="Transporter" evidence="10">
        <location>
            <begin position="25"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL36227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44172" checksum="D5364A85B309232A" modified="2018-01-31" version="1">MAHYRLGLFLLWSSLLVLNPLCKREQNKSTRTPATQHENQDEEDQDVERLSSQDAYLFPVIGSVVLFGLYLIVKFYGKEWITWFLQWYFTFAGVGSVGKSLISLTRWLVGDSRWSKFDKATILILKGPRELLSLSLRTPSFFLIPAGAIPSILYTFGGSATRRSALLTDILGLSFSHNALSLLKLDSFKTGVVLLSGLFVYDIWWVFGTEVMVKVATTLDVPIKLLWPKSLLFSGERGFTMLGLGDIVIPGMFVATALRYDYYRASRLGQTSHVGKPYFYSTLTAYAAGLATTMSVMHFFRKAQPALLYLSPACILSFFAVSLARGELRDAWGWADGSEDKIEQSSDKPAAKADDTQANGDVDGGIKISDEGLVENSTVSSSPPEEDTERKTKKKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRE1</accession>
    <name>A0A2G8SRE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRE1"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="910" mass="102001" checksum="715B504B7AE93D32" modified="2018-01-31" version="1">MVASSNGDLYTPFPHMPIIEEGVQSSEEGSDLHSPIFDAPYATPDARYHLDHYAYSDVSTQLLPPPTSAFDARYSAPTVDPHSRDPHILETLQVPSPTTIHHHLPPSHPLPDLALHGHPMLDLGISSSRFHPAVMNAATEYSMHLSQPSRIPEQQVRLSGDAVQSFPSRQPTTMIVAESKPQISLPSAAGPVRSNPSGSNPASTRPPRREASTVVIACRQCRARKIRCDSTRPFCHNCLRRNNECEYDAVPKRRGPDKRPGTRQRSCKKRPPDAEPTSASAKKKRKTNADGESGVLSFDVKVKENVTGGHRRGQLSSRGAMDDMNALNIPPPQGQLYINTSIPPRGTGPEAIYPKDGLSPSFHRSSVIMDYSDSNHSFARPVDVNVSQPLEDQDNLSYIPLSSPLEGASSWWDELLDQYNPTSREQSMQDIISDLTFLFTTSSYWLSFINVPLFFRDLHQPDLRSRMQSLVMSALAMALLMKSSEIELGRRGRELALTFRNKAQACLEDACHSQTFDHTLAEAALILALFESSCHPMYSPEQAIGALQLLDRIVHVLSLYSVDRDDPCANIFAARSVPIVYVHDGYQRPDSCSCSSYSTPLGSPGPLPIDAPWDPHWDDTEIRREECRRLCWCALTLVSAYTAHCSAFHTEPVELSLAEPSNYVLLFPGEACERTPGHQQADGRSPKESIWALYCRSMLLWNSCSCVQRDESLTTEERASFAIGAFQETREIQDALDMHVCNLDTGLMYVCREYLYNTRMTITYELRRLQDGDIPVLPPIFNRRQAEEWLLYQDQVAQRVKEAVLHVGETQGQLLTRRPFQVTWFSSQVAICLGLWEFNPELMHALELAKSFFIPLDVLNALWPCPGQRTKRDELRRRLENACLSAGLHPPLPEDLTLPPILRRNPRSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRM4</accession>
    <name>A0A2G8SRM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRM4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRM4"/>
    <dbReference type="OrthoDB" id="3243310at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="971"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115944" checksum="6DF71232AC84D140" modified="2018-01-31" version="1">MPSLSPQRSRKVAQSPLGQQGPMQNITPREMTPSPSFREKPRTIKANSMPSVPSLGQVLATRDVQMMYPQGAGQQQPSPTASNSSHQSRRSPPPTSRISPTSSKLASSATERERPTSPAALHVHSASLPQLVSQALPNPHHPRPVPRGAPPAFLNQFQTEEERWAVTDELMAKFEREHMQKFDPEGTSGVAYAGGAASSNLKRHDSLGVRPPAKDPAVERVRATDRASPKDSDGNGSGVGVGVAKRQLPVKEQSAGVVSRESPVATGGPGKGHTRERSGTVTSQQLAAAQGEVRTPEYRGSPQYPAPMASPGERTAGYTQYVPENYQNQGQQQGAQQNVPRKPVPAAVASEASATRLTPPASSKLATNTHTPPLQIMGSRPPDRSLPLQEPEEDNGHDDDEPEYTDRHHGSPLPASDLYADAHTTRYDTRHDRRDDDDETLNEEEGEEHLPQNKNSEDSESGSGFTPRSPSTTLPERTPVAYGPQTSQYAENQKTIRAAKHRSGSTDQLGMRSFDLTMFERDTVNSLRSSGTQDAPPSATRERASHSPQQPPSATQPEFSRQQLPQYDPRQYPISLNNVLDQRMGYGWNHSSVQSDDMQSLFDDPTSSYLQTFLRSASARPGAPIPPTPQSHTAAPSPSPLISATPSDIEPRQIGSPYPYPFTHIRRSTVSGPLQAPSTSYDMNNPAVIREQLALQMQIYALNNGLAPPSSESAFSPSSTPFPGPGYNPWAFVPAGGGLGMNAQTVAASIRSSPSHEPVSLPPPPAMRGRGLRRRDQNGHMRSQLQTARTAARRVKPPPRVDSTQPRETSPEPSSGEETAGEERFVDQYEQEMDGIINGKGREWNGVEIDASPPEEDDGEWVDEEEDGEEDDLLDLEFHPSYMTNPQKRRRRFDTRWDALVQAFQALDRETDATLVVLAAPSHTTKLHSLTSRSLRRDPALLNSTALASVRRSFSHLASQRRAARKAQRMSLAERLSNRSDSSADGSPGSGTPREMDLRRALETALGSLGALSTIYEQREARWRDEMRRLSDDRERVELLLRQALGPVLPINGHAGANINGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRN5</accession>
    <name>A0A2G8SRN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_00117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRN5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRN5"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF78">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="560"/>
            <end position="561"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="651" mass="71874" checksum="8265BA6C23275C99" modified="2018-01-31" version="1">MGHPEEVDVIVCGGGPAGSVVAGRLAYADPTLKVMLIEGGANNRDDPWVYRPGIYVRNMQRDGINDKATFYVDTQKSSHLRGRRSIVPCANILGGGSSINFQMYTRASASDWDDFKMEGWKADDLLPLMKRLENYQKPTNNDTHGYDGPIAISNGGQVQPVAQDFLRASHAIGVPFSDDIQDLKTAHGAEIWAKYINRHTGRRSDAATAYVHSVMDTQNNLFLRCNARVSRVLFDANNKAVGVTYVPSRNRANNADVVETIVKARKMVVLSSGTLGTPQILERSGVGNAELLNKLNIPVVSDVPGVGEEYQDHYTTLSIYRVSNETQTLDDFLRGDKDTQKELFAEWETSPEKARLSSNAIDAGFKIRPTEAELAEMGPEFNALWDRYFKDKPDKPVMFGSIVGGAYADHALLPPGKYVTMFQYLEYPASRGKIHVQSANPYVEPFFDSGFMNNKADFAPIRWSYKKTREVARRMDAFRGELASHHPRFHPDSPAAARDIDLQTAKELLPNGLTVGIHMGTWHSPSEAYDAAKVHEDIKYTAEDDQAIDDWIADHVETTWHSLGTCAMKPRAQGGVVDARLNVYGTQNLKCVDLSICPDNLGTNTYSSALLVGEKGADLVAEDLGLKLRFPHAPVPHAPVPIGKPATQLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRR5</accession>
    <name>A0A2G8SRR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRR5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="196" mass="22579" checksum="0AD88FC739625A73" modified="2018-01-31" version="1">MCDFDESLLRPGAFARTPFGTPFFALVTDPETDTSELGKLEVGGRLRQELAAWERIQRTRKLKVLMDNKRTDQIAEEAPNTGHRVHRRGSHNFFEFVDRDDNRPDTATATTEESEAGADIDSEIDGFVLINRNHATGTVFWNQRTHSTRSSRVRVRPRCHHHKYQLELELVDEDEEGVDPWAAFMDLLRPVGEMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRZ1</accession>
    <name>A0A2G8SRZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRZ1"/>
    <dbReference type="OrthoDB" id="2755983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="190" mass="21755" checksum="5AA3B610A8BB7FC6" modified="2018-01-31" version="1">MTGCQLLGQTLCGQYARREMMLRSQLRQSINAELARISGCSTARMRWSLQEYLDEIFFGLGIRFAWVRYLLFANLSKHTGLARIMHITTLWNTGVIYFARVTPEEREAALRDPLSAAPGPLHLGLPEWYGRSDIKARRYRPITNPLSLPYKYERNGPKSAKTVSDEAEVAAEAEVREAKERMLEAQLEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSP7</accession>
    <name>A0A2G8SSP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSP7"/>
    <dbReference type="OrthoDB" id="3197626at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="356" mass="39499" checksum="B5F142FD956BCBA7" modified="2018-01-31" version="1">MVDWTSQVEIQRGTGMFPYCYLRRSSSYSTLLTVAYANVIFASFGLYIWEVFQTSDFEWSVVEGKRKLKLHMVCRKHSRVVGDLSQCNVPCVQIPFFIARYLIIFSITSLMASFTVKSPINCGALYAFICVAGNLSIICASITLMLRTIAVWERKLPIVATLGTLCLAHCALLFRSMFITSASYSSGGQTCVLTALSNTNRVFLSVTFWATLGFNLTLAVVHILGLMKTGEQLGFGDLLFREGVIYYLAAFTFNAVPAVPATVMTVVSATRIVTRLHDVDDDDDIYVHSATQLTTPRLPNPPPIRFQNKVARYPSRPEVHVTTDRIVMEDYDPSPSSLTDKAASLTGDDKSTFHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STK7</accession>
    <name>A0A2G8STK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STK7"/>
    <dbReference type="STRING" id="1077348.A0A2G8STK7"/>
    <dbReference type="OrthoDB" id="3199068at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="62"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="267" mass="30243" checksum="F190744707C8930E" modified="2018-01-31" version="1">MSTAASSASQAQPPSRSLELSPSPDSQVAYSTQQVVALQSVLRETCATSKMHKHDNYYFDDGNIVFEVEGILYRLHRSILERHSPVFRELFMVPLPDGSNEGMSDWNPVVLEGIDPKGFTRLISLLYPQTLGDCNVATADEWMSIFDQAERWQMGYLRECALNQLRTTYISPIPKIVFWMRYHLPKTEIIPSLIDLITRPDSLSLSEAYELGLEMLVKLAHARDIARDNGLCPRSTGFSVKRDEALARIVHKVFFSQESTFHTLTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STM5</accession>
    <name>A0A2G8STM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_00821</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STM5"/>
    <dbReference type="STRING" id="1077348.A0A2G8STM5"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553563" description="J domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="43"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL37129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="323" mass="35089" checksum="F4ED294086D36762" modified="2018-01-31" version="1">MRVLHLVAFLAVLVTAVVAWTKEDHEIFDLVSAVEKAEGKDTSFYSWLDVPSTASTPQIAKAYRKKSLQLHPDKNKGVKGAHERFARLGVVAAILRDPAKRERYDFFYKNGVPVWRGTGYYYSRFRPGLGTVLTFLVIITSSLQYVVQKINYNRDLKRIEEIVEQARIAAWGLKMNPVEGQRKVKVNLGGQSRLDEDGNVIPGRTVDMVVEGSQVCILEPDGSLLPVDSETAVAPSIKRTWFLSLVTGLLGKVTGRDGAIQGAGQDGAVGEDESDDASGVSSDVPGSGTATPKEGSDSGRSRNGKIAATAMAGGRRRKAVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU28</accession>
    <name>A0A2G8SU28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU28"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU28"/>
    <dbReference type="OrthoDB" id="276151at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="13832" checksum="7AA31D290E857070" modified="2018-01-31" version="1">MIRRPREDDCSPTTGLRGRRGTVERQGGVVTGRSRMGSLFIHVVKSTGVSVIQWAAAYHHLLPPAYLESVPQEDGANQCPRFPTCVYYDEVLGDGWEKVLDEVPKISMESHIGKERIVVRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLE6</accession>
    <name>A0A2G8RLE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_15032</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLE6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLE6"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="53"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="307" mass="33956" checksum="94AF45D935E1B907" modified="2018-01-31" version="1">MNSQDAWRRLSQQLQRVSTSGGGGGPRLPVRGFFTGSGLLLALVGGGLALNASLFNVDGGHRAIKYTRLHGVKEEVYPEGTHFMVPWFETPIVYDIRAKPRNIASLTGTKDLQMVNITCRVLSRPNMSALPTIYRELGTDYDERVLPSIVNEVLKSVVAQFNASQIITQREQVSRLVRENLTRRALRFNIVLDDVSITHVAFSPEFTHAVEAKQVAQQTALRAAFLVDQAIQEKQSIIVRAQGEARSAELIGEAVRQNKGFLQLRRLEAARDIATLLAASDNRVMLDSQALLLNVADDAKDLLSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLH0</accession>
    <name>A0A2G8RLH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_15057</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLH0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLH0"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015215">
        <property type="term" value="F:nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="115"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="210"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL22369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="314" mass="34926" checksum="8B5AEF3236747743" modified="2018-01-31" version="1">MIAGAGGGLVASVATCPLDVVKTKLQAQRAVHGHEAYEGVVATVKNILKHDGIRGMYRGLGPTILGYLPTWAIYFAVYDGIKRKFGERPVGEVDGGRHVYPAAQVKGYQPLAREHPWTLHILSAMAAGATSTICTNPLWVIKTRFMTQPREEGRYRHTLDAALTIYRTEGWRAFFRGLLPSLLGITHVAVQFPLYEHLKRVAGRDRTEPLTATQILGCSATAKMTASIVTYPHEVVRTRFQTEKRLLNGNGGHEPNTERRGIIRMTQHIVTHEGWRALYRGLSVNLVRTVPNSAVTMLTYEMLVRSLNRRSGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMI5</accession>
    <name>A0A2G8RMI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMI5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMI5"/>
    <dbReference type="OrthoDB" id="2556122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045226">
        <property type="entry name" value="Dsc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025390">
        <property type="entry name" value="Dsc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019413">
        <property type="entry name" value="Dsc3_ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049:SF1">
        <property type="entry name" value="DSC E3 UBIQUITIN LIGASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28049">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN YOR223W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13373">
        <property type="entry name" value="Dsc3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10302">
        <property type="entry name" value="Dsc3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="319" mass="34723" checksum="603F0C940D9FEA05" modified="2018-01-31" version="1">MPPSLSEKAKGKQRATEPEHAESGTPSSKDLTIRFTEGIPDLTVQVAEKDTVKDVKDNIRAARPQLKDRRLRLIHQGQLLADTAQLYSRIASAQGRRRKPAAGPSSSSSVTGTPDGYEELAGEGAGEEKAGAAGTTWLHCSVGPQLKEGEVEDGKVQTAQLKPLRGFDRLAAAGFSEQDIANIRLQFHTHSAGDYLDQEFDDQEDFDEHARVLEEQWIDSLDGPSSDLTNSQTAVSSLHNGIVLGFFFPLLPLFFFRGHKPAVFWDGGSEQEMMVEPVFSIHAASSVPSASVTNCIRELVGDCDSLRILEVLFCVYAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN71</accession>
    <name>A0A2G8RN71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN71"/>
    <dbReference type="OrthoDB" id="5121585at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="856" mass="94044" checksum="7EC31F8E934D5416" modified="2018-01-31" version="1">MPSDFSVFTRLINETHESLSLDSDHLVAEHGDWYDVPKSIGAGESKRFSLQGRLPAFYGCEGEFTYRILDTNSRILSKLWSYQVDPIQSGNNVKVRDPKPEALYTVSFQTSTKGPHGPWTEGKVNPDGHPFWVEYTVKYQPRTYFFLLIHISASSFHIVRNTRRKLVYGTHSLWDSKDPNAFNDGNQGSYQPNLFAYDFVSPIAIKSAIDVTVRPVDLELEGAEAVVVGRISNTRVFLSEWFILKVNADQKVTTRIISPNTSTMPFAWNDDVQWSLELRYSDRPVMPLPRTPSSTRLELYWIASHVHFAFKNEIPVGFLRDVLRRAPRQLEWTESGSSNLKASDGPVGVRTSGYYQYVTNAVFGDFCKKYDTVTGASHFNMDSYGGFFAQGRYRLADASGVPGSLLRAVNCMDQAAMLELSCSFWQEVSDPRPTSWLLQCPFGYINTTHLVGITQSDFSGPLIPVNNPFFGTDRSKALLDINDTSRSWFSCHVYVGYSSLFDRVNDGVFDACSGPHTGTENAESYVTAAIDTQTNLYHVHNTHPGTVASIQQSYGVVGIDGHSPTSVHNSRSGLNLTPFRQLLDRLAPVPNAGTVTQVDWANLSDWVESVLGDEWSVVFGSVTASEDIADAFWDLADAANPDEPVCVHVIVPSVAGTDGALDVAASAEAARDRLATILSSTDRDPEGVWTTGTFNDFGDYSLQYAADLAAGRVIVVAANTVVDIAGRSSTNALDRVARQLFGHTVRSDAPALSIPVLEYRGDGDTLTVHGLGTEFTIVFAAVGQLSVAGATCEDTGVVFDDSLIVEVEGGNSTVEFKFVTRELGEHAVRIHCAEMLTMVCATKTLQVNVMEDDANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN92</accession>
    <name>A0A2G8RN92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN92"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="205" mass="21674" checksum="3DCB3FAA63F56C87" modified="2018-01-31" version="1">MRVFQTLGEELQLETGDNVVRSERYGLKRDHRADAERREPRSSQSTEHAVVSTTVTPGAWLPVSSAFAPTSFVPIHNAYTVSRGCSVPSEPLACAAKYVGKMGFEEGREGAGGEGVGARRADLSEGEEGEVAVLGGEHEPHRPPVVVAVLVNESVAGVAEGDQVLDLAGLGPGTVASKGRKCKTFREDDGDESVLSTTMASIRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPX2</accession>
    <name>A0A2G8RPX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_14873</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPX2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPX2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL23560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="532" mass="59266" checksum="0DA3E02F6D5458DF" modified="2018-01-31" version="1">MTIYLSQREPEVPPSPQPGTMIALGPTYIQALLAGLVASVALWLWKSRTQSRLPLPPGPKPLPIIGNLLDMPFEDRARKFWEIGRTYGDIVYFDVFGQPMVVINTYDAAVSLLETKSANTSDRPRIIMADLLGLSERIFALMGYGRYRPIFLRQAKRFLQRLLNTPENFIAHSHLVIGASIMEVVYGIELTEGDKFLSIAKKGAEIFSKALSPGRYLVELFPILVHLPAWFPGVEFKRDVAKWLPDSCAVPRVPYATVKRAMVQGNAKPCMTTTLLERAASKGPLSPEEDQLFEDVAGLAYGAGTDTVRGRIIIPHYRQPLTYSAFPQSYTYLTTFFLAMTIHPDVRRRGQAELDAVVGPDRLPAFSDRQSLPYVTAIVKECLRWHSVLPLGIPHRAIHEDEYNGWRIPAGTILLANAWAMSRDSAVYPDPDKFVPERFLKDGAIDPTVRDTLKYQLGFGRRICPGLHFSSEALFIFIASVLHVFDILPPLGDDGQPVLPDPVFSLGDTMSILPRSAAAEALVTQLHKEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ27</accession>
    <name>A0A2G8RQ27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ27"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ27"/>
    <dbReference type="OrthoDB" id="3270670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="491" mass="51279" checksum="B96BE86AF0C0F0F0" modified="2018-01-31" version="1">MSAIAAHYASSPDRRYAHDLAYDVPQPFFNYTHSSLNAVTAAPSSSLDSSYALGSGAAASSYVWDTPYPTSSSSSLAATTAAFASSSHPASAGPSTSSNLTAYAPDYASHRPSFAVRSSAASYQISATSSSSPLPPAPSRPSYTSASRSYSSLAPAPTTPHAPSPSSSRLQNATWDSTSLYTIEPSEPIAAPVSAPSPAATSPPSTPIKSEDPDGEFIIEVTVPSDPAPGAMPEVPLRAIHAVPEMKKMMYAFRLENFAMHDGIKSAATQPGSGGIEVGPLRERPVEIEWQVQLDVPLIAEEEEAFRYGSMPQTPSRAGAVRKSALYRADTPMSPRESARASYASVGSASPALSMDYPLAVDNDGWDTSSAYGGNSSSSASAATSSPNFAAVMTPAQSLGWSMRGYQAGDVDLESSTYRRPPPPSGQSSLSRVSQAHGQYILSGSSKTAYQQSSPYAGYESAGYSRNASGGRYAQEVYASSSSSSSTWFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRQ6</accession>
    <name>A0A2G8RRQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_13950</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRQ6"/>
    <dbReference type="OrthoDB" id="4457at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="145"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="346"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL24197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="438" mass="49120" checksum="F6F06CFDC3DC9FFB" modified="2018-01-31" version="1">MTAGLARTRSSLHFLRTVQYRRCYSTRPPSVSLLGKEYPTDKTTNITSAIADKVGRNLYMNPSHPLGILHALVSSHFRDFNSMVGLPPVVTPAQNFDDLSFPPDHPGRAVTDSYYLNDSAMLRTHTSAHEVETFARGERRWLLSADVYRRDEIDASHYPVFHQMEGARVFASGAEGRAELEADNARLAGELARARIAIEDVPHVSPTNPAQAAHDPVLAELVAQNLKLSLNSLMLSLFGDHAGGEAGEPLRVRWIEAFFPFTTPSYEVEVFFRGKWLEILGCGVVQQQTLDRANVPNSISWAFGLGLERIAMILFSIPDIRLFWSQDPRFLSQFTAGQISTFKPYSKYPACYKDVSFWLSEAGLHDNDFCDLVRDTAGDLVQDVVLIDDFTHPKTKRSSKCYRINYCSMDRSLSNEEANEVHAQVIASLKDKFGVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRZ8</accession>
    <name>A0A2G8RRZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_14035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRZ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRZ8"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="108"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="517" mass="57039" checksum="A9F831E78B8C2629" modified="2018-01-31" version="1">MSSPTGTPLVSGTSTPLTRSGRSTPLHFRDVVMEVVRHARHEKESEAHRLFRQSAGHKPKGQLGTLPQTVNPDEETVPGIEHPGSTGVIYCSDRAMANGFSYASSHEWANLGQGAPEVGPIPDAPERPSSIPVPEDSLEYAPTTGVKALREAVANLYNETYRQGKLSQYTYENVCIVPGGRAGLSRVAAVIGEVYCSYQVPDYTAYDQVLSAFKRLVPVPTALDEKQQYRLDLQQIKRDIMTQGLEVIIASNPRNPTGQVIQGQDLKDLVDTCRDASATLIMDEFYSWYLYPEKEEDFGKSVSSAEYIDNVNGDAVVIVDGLTKNWRLPGWRVCWVLGPKNLITALSQSGSFLDGGANHPLQLAALPLLDPARVHLEKVALQRHFKAKRDHVLARLDELGLHVFVPPVATFYIWLNLEHLPAPLNNGLTFFEELLKERTIVIPGIFFDINPAHRRNLFHSPCHHFVRLSFGPPLADLDAGLDAMARVLKKAKVHGGHGIGHGYKKSIDGVHGIDKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSG0</accession>
    <name>A0A2G8RSG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSG0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSG0"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33720" checksum="4CDF54510218562D" modified="2018-01-31" version="1">MSSTGEGAKENDPLHALDTAYAMDEEGLTFMKAQTGIEDEQELKKHIIAVRAEGYSIFPYGCIMRFAFLQLRLSRLPAYNQLLALGKERKDAIFLDIGCCFGYDVRKAIDDGFPTGSVIAADLHPEFWELGHKLFKSTPETFPVPFLPGDAFDPAFLEPTAPFTASRPPPAPRPDLATLTALNALRGHVSAIHASAFFHLFDEERQTQLAHALAGLLSPEPGSMLIGGHRGQPVAGVRTDLGRRRQDGTKRFAHSPESWAALWDGQVFEKGTVRVEAVLREVERPGDLAGVSGDTKSYNLCWSVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSJ3</accession>
    <name>A0A2G8RSJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSJ3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="192" mass="21157" checksum="72CE0267D8180787" modified="2018-01-31" version="1">MGARTTRRRPLPVARRHRQGLLCRAVIGRRASPPARPLPLLPRVVVPSVVCSSLGCCSRTRTFRSLRTVCPPLRAVSITRPFCPSALTFFFSLLSSGAFLHILHSPPSAAPVAVPARVCFVDCLFSCRRPSVVHLYHRSFHITHTPSLASPIHIHIHAPHSVLIAQRSPPPSSVSAPTTPAIDSLRKHRRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSW9</accession>
    <name>A0A2G8RSW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSW9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSW9"/>
    <dbReference type="OrthoDB" id="2732296at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="264" mass="29539" checksum="262C4EACC9CF5EBD" modified="2018-01-31" version="1">MSLVPTFGAVLIGDMISAGLYGLTTLQVYLYFQNCWNTDPPRLKAFIFYVWILETVHVLLIGAFIFRSLITEFGNAEALNVTRVSDDVTTAITGLIIFSVHLFYTRRLWILSEGSRYRVVLTATVMILAITHFGLELAVMVLTFKFPEFAEFHKITAAYTGSLGVAAGCDIIIAIAMWHFLHSRRSGLKSTNTMVNRIITFVVITGSLTRYAFDLTFYGSQVTTFLSVVDLAILICFVAMPNNLVYLSMYNLVNNLYANSLLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSZ8</accession>
    <name>A0A2G8RSZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_12514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSZ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSZ8"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL24630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="263" mass="29767" checksum="353E72540A07DE9C" modified="2018-01-31" version="1">MARGPKKHLKRLAAPSSWMLDKLSGTYAPRPSPGPHKLRESLPLTIFLRNRLKYALTGKEVTSIVMQRLIKVDGKVRTDPTYPTGFMDVISIEKSGEHFRLLYDVKGRFTIHRITAEEATYKLLKVRKVAIGNKGVPYITTHDGRTIRYADPLISVNDTVRFDIEQGKLTDFVKFDTGNLVFITGGRNRGRCGVITHREKHIGGFDIVHVKDSLERTFATRISNIFVIGEGTKSWVSLPKGKGIKLTIAEERDVRRRQRAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT43</accession>
    <name>A0A2G8RT43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT43"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT43"/>
    <dbReference type="OrthoDB" id="79367at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="794"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="661"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="923" mass="98016" checksum="F160907670D5284C" modified="2018-01-31" version="1">MATIEEFETALKEVVTAKRLSQSKMASLTEIAMRCMENDTQMVSILYRTHKGLTTGGKTWSLYAFDALARAARHQVNKNQINQNQGHGNCVTFLRKIEGVLDGLFEDIATAGTNDLKEKAKKILDIWAKSNTFPSAVLSPLYALLKQAENDKEPDMPPDQSANPTPNPHSMPALPPTQPPNPQPSVTPFAGADIQSALFALLSKAANVAGTNGVAPGQTPPNIGPASAPSAPAAPPTPVLDANQLALLHQLAQTAKGIAPASAQTQPLGVVQQQPVPSSLVPSNIAVPVVPPSALANVGGTSTSQPQVYRDDQYGPPTTHARESEPPHHQPYGHGGRYTPDAAAAAQSHDPRAGGYLRGSDYGTPSHDRDAAVTANLTPKPTGSYEYDEHGRNRPIPDPDASYGPGLHDHDRDRDHSPRDPRRDGPPRGFRGSPGRGRGRGRWDDRRGPGDYHPQDSRGRDRDHRDDYRDRDRDYDDRDRDRDRDRGQRRRRDSRSWSPQGRRRGRPPRSPTRRRGPRGDRDRRGDGEGGFRERYTYVPGRDGAEPGFDEFGRELRPSTPEREHEREPECGPALATLVQSPMPNASSIQSSHPGQRQGRTESPFPPGTSTASVTASDGGSVAPEDALSVREPGQGLGFGNYNHQPAGGHPPPPYGAPPSEPSTSTMASLSPAPSASSATLPPASSSTSTSAADSGGEGGLDTFDRAAFDPSQPASWEALGRAWATTHGRAPSQEELMQFVFGAPCRRLRPPRDWGSTTTGLGAMGVGAGAGTEDEVGATTRAAMDTMSVEGVGAEGGGTDLGEGEAAEGSMGRGAGATSRGTAEEITDRRGREEGAGAGSSMAAARRGTNMVEAELHRDTRMSMTVQVMGDLGEKGMEAGDGAGLEAAEHMGEEGGEMGEGDTDMGPEWLRGADVPAVWVRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT96</accession>
    <name>A0A2G8RT96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT96"/>
    <dbReference type="OrthoDB" id="2752751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29803" checksum="CA86A9B5432B479B" modified="2018-01-31" version="1">MDNLRSLKLRLPTPLGHNALDSATRSFDALRDVSLDCKQASLDDAIAFLRAISSPHLESVRLDHCECPTSSLATSLLEFCTVLHNKFRSTVRSISLSVTPIGSPIVFEHPLVKYLEPLLHIHELAEFRFAISRTSRNVSIPVPESNLVSIAESWPRLSHLGLNYDPADEPPTVWTISTFAWRCPSLTTLNLPCIDARDVAFASLDSPHPSLISFGIFDGGWDSLIPEPGNLAKFLKALFPKVVLEQPQLGAEQWTQTVECLEKLQAVVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTP3</accession>
    <name>A0A2G8RTP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase family Tnp2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTP3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTP3"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="109490" checksum="24632ED9E0B70B4A" modified="2018-01-31" version="1">MCKLVPDGMKLTFDGVPASIESSAPEPSTPGFRTLAMWLQDQVRYVSEELAPIGDHDMDQRRLALLRRLTSEIDRLQQIKETAWAGHIAAHIMKSHMSETDQNGPLCVKREGSRGVAYAASLQPYVLAGLLMATVLHSLAATARMPVQYVLRVLQVVLYGAFLYCNSTSGSKTTSLTPDQKSILETVPIDIKTIINDLELSPDFIRFACCPTCRFTYPPDPKKPHDPYPRTCIHQETDKPVCGTPLVYAQSHGPKRKKGTPAITYEPFMIFPFRSPTAWLVDLISRPGMRTLLRQSWDPKDSPPGVVPDILDSEAIRSFLGPDKKTPFCSQPDDTLNLVFTLFVDWFNPFGNKKAGKSHSVGVIYLALQNLPAHLRYRAENMCLVGVIPGPHEPELHQLNHFLRPLVDELLRLWHHGVYLDDCSQERALLFIRAALIALVCDVPALRKAGGFAGHMATHFCSFCELPKADINNLAREKWPRHNCEQHRRYATQWRDAKTEAAREAEFKAHGIRWSELLRLEYWDPTKFAVVDAMHNLFLGELRHHCRDVWGLDIKDKGGDGQQLDPHNPDQQRAQLERVRAAVLGGHRNALDKIRKGYIVAVARLNNVAPMDGNPAKKAYVDALLNWGKSSSTVNLPPVLSEPTTDFLAPDHAGDCDIPRSRIIDRETIEHIRRDIGATYFPSWVERPPRNFGSPSHGKLKADQWRMVYHMPLTFMKYFYIGANLRWFLTGFEWPGTDAFRSMVNAFREAFASLSSGARMGGYVPFGAPSCQPTLEDYDEKKEERLPPPVYSQLVTLLSSPMTHFSSGHGSLPDHPILNDSANYVSRVEHRGVSFATRRSGLRDSFIVFDNASPDQRFPRAGQITDIFLHVRIEREQSIAEYFLIVDEYTSLNDLDKAKDPYRRFTDLQTRLFYRRSQPSPRVIRLENIQGHFAAFFYKPDDIAEECVVVRSLDRVCSFTSATPAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVI0</accession>
    <name>A0A2G8RVI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000052">
        <property type="protein sequence ID" value="PIL25513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVI0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVI0"/>
    <dbReference type="OrthoDB" id="2013610at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="242" mass="28131" checksum="39DD6A6E689EDE3D" modified="2018-01-31" version="1">MSTAYHPQTDGQSERWNQEIEAYLRMYCLRRRNDWVKWLPIAEFAFNSHVHSSTGYSPFYLMYGFEPQFHIPMLSMAVPSADERREELHQAREDATSALTLAAERMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESQRLTVEPCSALAAQVLVDTLARLRKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVN0</accession>
    <name>A0A2G8RVN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVN0"/>
    <dbReference type="OrthoDB" id="2757163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="14879" checksum="FA9B6BA441F5E53B" modified="2018-01-31" version="1">MYGGLPVGTVASICSLATNLVATVLTAYKAWFGPPEVCPEPRSKRVPEEHPSREHLRAPGALYCTLWIVVVVWQTASWVSDRKLSSSFLLSLELSHKLKNESASFWFKGGVLIEGCLVPLIAIYPTAIIVLVALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW93</accession>
    <name>A0A2G8RW93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11531</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW93"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW93"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013546737" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="4">
        <location>
            <begin position="474"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="673" mass="70341" checksum="3D952BE5E0D36FAC" modified="2018-01-31" version="1">MLKPSLFLLSLAALSTHLPHASAVTVYNQDGVTAVSAAATGTGAASATATASWLSSLAAYNNVTLTPPALPNPMPSTAFSISVMNSAQDVSGLGIQQAGDFFGFSVEMSVVEQVIGKNATYVQVPFLNLLATVADRAGRVRVRVGGNTQETATLVGSLPNNSMIAKDKTDATNPTDTPVLDFTAEMIYLLANVSSLVNVKWYLGIPFNDTTNLRLQIAEAAESILGDNLLAFQVGNEPDLYAAHGHRPQDYNQTDYFNDFGIVVNAINNDASIPTRGNLVAPSLQGTWTLQSVFDTGFITSYSSAISILSVEQYPDNNCAAAFPDAGFGAPVNPQDVFPNYLTHLAGKNLIAPYLPSIPTAQQAGKQFMMFETNTASCGGFPGVSDSFGSALWAVDYGLQMAYSNFTGALLHIGGQDVSYNPFTPPPTNISTTHGWTVGPIMYSTLVLAEALGTTNTSQVMDLFANNNANSTPAYAIYENGALARMVLMNYMTEQGGQGAYTATISVGGGQTGEANATPSQVKVKYLLAPSVAEKDNVTWANQTFGGRFECDGRLSGTEDIQTISCDTSANTCQIPVPAPGVALVFLSSAAQGATDPTQTQTYATTAVTKSANTVSINPSVLATSNGQSGKDRSLSSTSQGSSDARRTVGAPGATLLAMLVLGAWAVAGALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXI0</accession>
    <name>A0A2G8RXI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXI0"/>
    <dbReference type="OrthoDB" id="2744661at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="17884" checksum="B65E9B15BE47A712" modified="2018-01-31" version="1">MPWMTTFVCQNVKFRTDERPGSPCADCAEWSSVNISVHELGVETPWLLVEKSEDKDRSVRPIIFRAMRVGWRISCDEQTMTITMQGDEIEALTAGHQKLRFEKAADFWSLMYQISTSRLREYTAQSAGGRTQAESRQIWSTKRIELYTVPMNVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXJ7</accession>
    <name>A0A2G8RXJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXJ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXJ7"/>
    <dbReference type="OrthoDB" id="2747971at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="382" mass="41957" checksum="9C1B96A3012ED7BC" modified="2018-01-31" version="1">MEAADDLLAKYKKHPFAKGLLPFQSCMEALGTSESKIRDKATRRPALFSHAAVFAEADHPETGNYVPPDEAIPFGVDPKNVQRKANTRCFYTYILDTFTDISLYEGQWTLDEYVSGLPGFNARTVPRRAYLSGQDVRYRTRFWMQTPMFLRKGAQKEPSIATGHLHPWVVEADKQSKGFRGNPDRPRVWVKDGDDIVPISEREPGTLQRGDVVALSFTVTYHITTSNWFPQFHPADIIVLQSGDGDVPDYSAPEIDLYSRPPPSFGMEDPGDSDVEGSKEARRTGGGEGDGEMEDVVDGSMELRADNGGSGQHMDVQAGGRQGGTGSSVTLGSSGEGGHEAFELVPPGGGDDDNEDDEFVDVEAQEEVLRPLRSGRSGRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYA7</accession>
    <name>A0A2G8RYA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYA7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYA7"/>
    <dbReference type="OrthoDB" id="2797394at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="169" mass="18564" checksum="86A5E86E4884EE95" modified="2018-01-31" version="1">MSVADVTAHTELRKQQISVTRIQCIGAVNLARLTDTPPTPLALYECCMLRDGWTHEAGMVEHLGAEDMKRCFGASITLRQERQLVLCGIFYPAPPQRCRDRGFCAQDISDAADSVMRVQDMATKELLWDWMSWGLDPGPRGRVWRVQGGPARAGPGGAQEDFGGAATDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYS3</accession>
    <name>A0A2G8RYS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000041">
        <property type="protein sequence ID" value="PIL26679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYS3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYS3"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="105"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="572" mass="61981" checksum="4A42D64C99C8861C" modified="2018-01-31" version="1">MTPPDSRPGGICGWTPPDGNRDTLYTTIPSPASHTSPIYGLDALSPSPSPSSPPPSVTAASRSVSPDTTATEPEEGELSQNISPYYNATSLRRYKAKLKIDPKWAPRPPNAFILFRREYAERHKGEELQSPEKTTLSKRAGKAWHSLTGEEQKVWYDAAKQQAEDHQRLNPGYIFKPNKRTRSDHRKHPAMRSRREQVEEFVRKSTSTSRRRNPAKRGRHSSPASVASSASPEPPDTPATSRSRSCSNPPQVACPVPITPGGNNVLLSGDPFGSMSSLVERPVCPSKELACPDGSSPYFLFGDSYTESSDDLSEFWFDSFAPSPVPYYGDGTPDHMPSPMSAPVQMTEAQFAPSFELPPPSVASQGASYIPSTTAPLIARRRRSATTSMIPTSTPHAAVTSSLYGWARDELVTARMAPQSQFDAPRPSVSSDVNRQGQAPESAFLPMNAGDEVWGSARLHPGAGAAYKFHDDMLTVLVPGMDPDRTPRGSICTAHDAPPPPAPHSFADYSLAMPGPPQDMYISAAFDPFDTAGDLESYSVGHYAVHEGHETYAAPQGVEPYSLYLAQGGQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ64</accession>
    <name>A0A2G8RZ64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000044">
        <property type="protein sequence ID" value="PIL26608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ64"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="55205" checksum="E1F1D36643015619" modified="2018-01-31" version="1">MSSSSNSKKGKATNPQHEIESARERIRNMRHFEPEDNAEVEDHVEWVENMTLAMEGVASAGAPDGEVEAIADDVYLQHAAQLSHLFDNWPEWASPILTGAHERAQAAAAARRVADAEAERERKQAERNARLDAFLAKNKIPRLEGSPSGTADRPATPAITQPPVASSSATGASSKSGAKRKRDPKSPATTGAKPKKPKEEKEKKDNGPKLATITDPKRMCDLCRKIGVAVCKPLVKGKRCDKCVSDKKGCVHSEEPFGEWYRSLEPVPGERGGLTPFASVGRLTDRLVATPGPIAGPSGTSGTPIAPRSSTARADPETPTPPRTRRALSVELGALMLNFEPHFPTNPTPEPIASGSGEKTTEEDSGRTANDATGPAEVGSGDRLQAEATKLFASYVREGPANFGHAVHELGTDSLRQEGIRADGGRLGLEQYEADLVKRLRRKAREAAESAANADDTNEGTGDNENANDGTGEGMEASGLTCRRRRGAGESARKRKEKEKEKEKRKRRRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ78</accession>
    <name>A0A2G8RZ78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RZ78"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="294"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="933"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1214"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="620"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="875"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1015"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1055"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1232"/>
            <end position="1248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL26820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1304" mass="141024" checksum="F8840D384FCD7355" modified="2018-01-31" version="1">MAPARRRVSYVIPPPTDPPPRLQLPPHGVPRHGSTGPILIPLQSAGPPPPPTPKWTQHPRHRLGVSCLALDSSTQLVGRASPEGILYTGGRDGMAIAWDLGVPTMRRGQRYGYAGRGMRRWEVMTNWADDVIEEEAEEGDGYRSDGDVLGEVTGRARRRIPTDNAIPYEEQWETDMDAYQALKAHPPTSHFRQAVQMHSDWINDMILCNYNQTLVTASSDGTIKAWSPHTHGQSAPLHEPTVVGTHSDYVRCLAYCREQQWFASGSFDRTIRLWDLASASHRADPLITLHTPEGAGAKASVYALTTDPYGSVIASGSPERVIRMWDPRSGKRIAKLVGHTDNIRAILISEDAKYLLTGSADASIKLWSLSSQRCLHTFTHHTESVWSLFSSHPSLEVFYSGDRSGLVCKVDVEGCADVSEGECILLCQDSGSDRPGTSGSGSEGINKIVAMDDNLLWTASGSSSVRRWRVPGRRALRATALTAEGAVDSPVSSPRPLDYRHPDSPTRSKSVPRSPSLSQTNSRSSSPPTSLSNNGNTTADPELELDPDREGEETWYGIPFESLVRLTSPNDSGFGMGGPALRAPDAEIATLYSAASVRSVPRMVRSPVQAMFGQPPSAALRSSSPFRSDTLRSQTEPRPPNAGEDSQTVQAPRPRAAYEIREVAADAVPLRLEADEVIHGEHGLVRCLMLNDRMHALTVDTAGEVAVWDVVRGVCLGRFPCADVAAASFCGSAKSQKSEKSGGEETQRSPREALETVRERIEGEAVVPSWAALETKTGVLTVHVSERCFEAEVYADEAGYGHGHGHERMNEEIRFNIGKWVLRNLFYGFIREEQRQAARRAKEHGGHDSSQHRMQRGSVPSHIELSNASSHGRSRASSDVSVRSSSSASAGPRSPTGIILSPTMLPAVSPVISAAHRSSPLMTPMIPLHGALRDSGLPTIPQSPNLADATPMPISHGLRDSQRSDNSTGSGVPPSAYGTVNADYVSHHGISRRPSVSTPGGLTTPDDFSGWGGKSTLSVGSGSDATPLVSPSTPTMGSLMGRLNKAFSKTKRQPSENAGTMSQGTATSTSMDTPAEDPSPPIKTPAQALLAGPITPPSSSEAPTLPVPSSTSIIISEEAPSGWLTLYRGHVSSTGLDVRLLEEAMPLWSLECVLQNKIPPIQVTKVSFVLLPFKEPGVEPLPELLNTQQSKLTASRFLRVRKLTVHVQDKLDKIASGGGNSPVSMSMTPRSSIDRRSTSSARARDHDSRPRADELYEILCNGIILSLDMTLAAVRQYIWRQSGELVMHYRRKAVPVRPAIHGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZL8</accession>
    <name>A0A2G8RZL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZL8"/>
    <dbReference type="OrthoDB" id="2758610at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="813"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="362"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="703"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="737"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="773"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="872"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL26934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1113" mass="123750" checksum="A861141AE9652041" modified="2018-01-31" version="1">MSTTSNAAQGKGTSNEAAATPSLPDITLGEPLDLEASGELLDPHSLPLADPEPVPTRGGRPPSRPDATEVALGVKWGLTDYGRLMEGRSGRRVTRNTAQTVRSGESASAAPAGTYRGHRGPRLLQSVPLELTAAHPEASQDGRDPETVPRLPVETRLEGAGDREDVRRDGSLLEDMDERRDGRLLEIERRDGRHLTQSDERREGSLPDESDQRREGSSGDRISPDLPGLEIGEWRGTDGTVVRTYINPRIMQYIKDIKAPHRMPAWSELCDSSDQLGPLPAEWFPPSTSGETPVLPDTVYHDANASFEDEFWREVEEHATAAEENDLRRAIAASLSTAEADFAKRQQADTGHLDVNAIVVEVPETAESPKGHDGRYTTGQKQKHVPRATPQREFLQTFVGGNPTVRATSEPRQPPMTSTPRRHQTPASYKRDASQVPDSRWNPIAAGGGRGGGREGGNTPPDSSDPSSSSESSSSDDDGRGPSPEPDDPESDVPATPPRSKSPSKKRHRKKQREDTRETHKLLKRINLKPPAKWDGTPDLDKFDHWKYELNTWKELNKAPGYLIVKTMTNYVSGKASRFFMDHVANSSSEWSLENVYDGLFDYCFPDDFKAMLRRRLMTAKQGSLRVRDYVRELEHLASRFRDITEFQLVQIFWQGLNGYLQVELIDKGLGPETTALERLVKYAVRKEKANIEARKLQREFEGQVPGRTWGRFQNRTTGPAPYQPQRPDPRGPPPNQASGSRQGDYRNNGSQSRVQNYGGTRGQNNGQRADRQNQQNNLHSSQNGNKKAPPKRHQTVHTPEKLAELASGTPQCFTCEQPGHISRNCPQRQKARAPNVQLGAGSVRFEHLEDLADKARRTTTDIHVGAVAFTEDSDAETIGDSEDTDTDPYEPMDGSVLTEAGKLVRAKFLAYFDDEEAEAAGLNPAERFSFWCTDTTVEVTDRVPAAICERSFLDSYEITLEQLAEPRWTVSDAVQEAWKEWVTMPAPPDWADGFPDCRTRHNGHPALYWLRACVDKYMTAEYPQLMGTQDLMKVNPYKMGYLLSSVANDDKYFLTHTMVHAPGFDITPYAAALVEGHTAEDLKFFVDLGRVPPSPSSVTYAECCAHGRSPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0K7</accession>
    <name>A0A2G8S0K7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0K7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0K7"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="440"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="665"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL27277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="702" mass="77642" checksum="010BCC38B0BE2AB7" modified="2018-01-31" version="1">MSSHRTARAPRKSGGAANLSERATQSKGSEKMTMEPPTKKAKTKPLTMSLARPPMFDLSGIQPFPQQPKTSQSKLGGLGQNKRSQKDVKGKGKEKVQSGDSDTRLWVDRYEPESEEDLAVHKRKVQDVRHWLLEALGPNDPSGKLRKYRRILVLTGPAGTAKTAAMQILSREIGFDILEWRNTMAEQFSRSEGEWNGIEYEGSADKFRTFLGRASTCRPIFASQSSTSHTQSTQGSRISSSSASSTGAGSSRQRIILLEDLPNVLYPPTQSSFHAALEDFVDTPDRGAAPLVIIISDAGLRGEDAEDGGARWKSRSKEAMDVRNVLPPNLLRSPYVTQINSLYSNESWGSFNPIAATYMRSALKTMLDRHFASFSAMGTRPTKDVLDLIVESSNGDIRSAINALQFACTADQSSHNPPKGSKKGKGPSATVMLEAVTRREQSLALFHLLGKIMYNKRKGDQPAQSVSAKDIRRDKEIDAGLKDPPPLPPHLKDHERKASRVDVETLYVDTPIDASLLSLYIHQNYTQYCTTLEDCDALMDSLSWVDSSGGENWYQANPHQFHVVALGTLHALPTPVPRRSQKSFKPAFFEMLKQQHEAEDGVRDVQLWLQRLGSLPVSSWGARDVSLGISSLWRAGVYSEPIPPTHRNFSQLEFALVADGFAEIAQEGETAPDLPPPQREDRPLAEETITGSYLSDDDIEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1K4</accession>
    <name>A0A2G8S1K4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1K4"/>
    <dbReference type="OrthoDB" id="2758629at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="560" mass="60467" checksum="79530446FCE2A05E" modified="2018-01-31" version="1">MAEYQSAPPLAPALRSTAPRAGPCDYQTLLHGACPLDVSDRPPSLSPVESRRRRREEHRESLQTLVGTPPRPLILPTLREEDWSVSPLIRTGTLTPALVKAGTLRLPPACLRDNRYSRLRDTVPCRTLGGLDQSGAGRFIAQPVPTRDVRTCHNHLSDIEAEAAAPGSPTISDRDSTPSCPEWIRPYLSAFREQSKQEWNVYRPQTGLVAVSSISPSSSSSRGATPFPVIVVQSCNDPPSSRPDSPGSMYSVTEDLSYEDGPSLSSSTGPPQYTPCVVLTSRGERVSSREGNATEDSSFVTGPAGSDMVSPVKFYFPTLPTFGESAYLQVPSASCDSSGRVEEIDEEPRQTQTSSRTQSNAAEEPVGLQRFPTFKAKNTQDLSGDVGSALTSDMPSGTGRGQVITAAVGLGLSSDPKFSSVSASNDSHKVPAKGDPNLEPHSWLNYGDDSIRDSTVRFSEVLGHYGCSILSSDSVYSDTSFVSMQSSQRTSSGGSSDSHFREIIDLYRRRDTDDEVSSLHQALDGWVNAVTRKEAVRLGLGSNLPYGPLRHDYASRHSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2B0</accession>
    <name>A0A2G8S2B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_09945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2B0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2B0"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="212"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="415" mass="43804" checksum="231E2E3E913368DA" modified="2018-01-31" version="1">MPTAERLVDVLTSSTKSPSPDSPGLKDPGGTVLVEEVVSEECPDGGLRAWLVVLGVVCGMCATVGLLTAWGTFQAYYQEVELPHESSSNIAWIGSIQNAMLFAPGLLFGRLFDKGHLRLPVFVASAAFVACVFLTAQCTQYWHFLLCQGFGMGLASGVFFNMGNMVMAHWFKRRLGLAIACSFGGAGAGGCIFPIIVRALLHRISFQWTMRILGFTTLGLLLVSNLTIARRLPGTRDLGPLINLAEFKKPPYSFYVASLVVNTLALFTVFTYLTVSAVGEGVNADMSFYLLAIANAVSTVGRVISGLLADRFGPLNVLIPATLLTAVVTFTWPFATNVASFVVIAIFLGISTGATLALLVQPFARMGPVPEVGLRIGMGLTVVAIGVITGAPMSGAILDGTGSFKDVGYAGGASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S354</accession>
    <name>A0A2G8S354_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S354"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="98" mass="9969" checksum="B2A1244EB1D3A573" modified="2018-01-31" version="1">MQTPTGICTGAAPSTESSEGFLSVAALKLTLNTFFEGESQSAVNSSNTSGVVALDARTGDDGDDGTESSARRTGSVAALCWEGVGECSKCSERRAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S363</accession>
    <name>A0A2G8S363_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S363"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="94" mass="10307" checksum="2472163C8AA47D91" modified="2018-01-31" version="1">MRKPWIGYVERLVLCLYAVAFLASSKLELTRGAQQHAHTPPADSGGWHGAQSMSLIVSAHNYTRLPAQIPGVRRILSTHRAHGGHDPTGLFRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3R1</accession>
    <name>A0A2G8S3R1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3R1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="255" mass="28363" checksum="7C568AA13018770E" modified="2018-01-31" version="1">MSPPPLPPRPSTPLPDDTMLPLQPISASHDANHRANGAASSEEKTNFPTHDTASPSESSTAFSEPTDENPFSDCYEVPGANPFSDFYEVPGLFPKHPSAFDAEDERKMVWEYLDARSEETLWASTKYCGLTETVRQYHVPQSLHERLLSNMFGFGVNGAYAAMGGPGYFDLWGIYLEPDHQYRGARIAEVGDLHVLRTMQHFRALPYYNHDWLLEPTQAVRVPAGGETTGEVTEFGDPEAEEGAGEPEYDETETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S428</accession>
    <name>A0A2G8S428_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S428"/>
    <dbReference type="OrthoDB" id="2758311at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="543" mass="60534" checksum="39249FFB77DB9B1E" modified="2018-01-31" version="1">MSDNLSTAQLLSHLKRCEDCEYYVGAPVLCKGQADASKKGFWYEKCLNNAQPSPDSCNFFEWRPDIPRGKATGGKKTPCPGVLCRQGSKPNTSNVECTFGVCVKCCRHLQAHLTIVRSCSISEHRKGVVYPTPKANADLQEDSAPPRRGRGRPKKAENPGKAEVSKRTLGRDEEPDSVRVTPSRAPPKHKSYATPTGPLYQARMSALDAEHRLEVDRRAERAKQDQAHAFQHRVALQWWAKDGDGPELAEVVVDNPSSFHPKDVPHLVDRFHCDTQPFQYYDPKNCVWYTGSKYSAPRDLKKLGPNELYYRSEGVNSGPGMPGQSKKRPAPDDTPTDDTPRRPMPPFAHFPNTPASTPRRSNSPAATEPPMSGSSASTEPPDLDPFFNAFDFTPTTCDKGVPTYAAINATEPPLPALFPTDPDITHPFPSTSTLLTHPQSIELDLSTAPRGRGAKPWPWRYVCDMAAGFAAIRVLEDSQPPVDTKDAFKDVFKADFKLTTYREQLRAWRAAGLVAGERERWIQYGRTEAGEWLTFMRSWRQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4E1</accession>
    <name>A0A2G8S4E1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4E1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4E1"/>
    <dbReference type="OrthoDB" id="2757183at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="126" mass="14559" checksum="9CF545E5D723A62A" modified="2018-01-31" version="1">MPAPTKPPVTHYEPAPETQEDNYAPVPIVDFAKVGTPEGRAELAPQVREAMRTYGFICIVNHGLTQTQNDRMVDIADVPFSEVPEDEQHRLLSKVRELREWKRYKPRQFWVGIRPLCTREYVAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4P5</accession>
    <name>A0A2G8S4P5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08803</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4P5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4P5"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF867">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="189"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL28759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41314" checksum="3A170915EECD40FC" modified="2018-01-31" version="1">MPGTTLPSAPHYVPPPPTKESLEWADLPIIDFSKVGTPEGRAQLAPRVRDAMRVHGFLMIVNHGWTQTQNDRMFDIADAPFSQVSEDEKKRFQTKTQETGTAEGYKMRRVWTIDNGVRDELEYYTFFGQANHPDVLQPFLPEYQQFARHNHFDVLHPILRLLALGMELPEETFVDIHDFNDAAVKYARFLKYYPRTEEDEAKSKNVWLKGHTDIGTITILWSQPISALQVMSPDGKWRWVRHINNALVVNVGDALEMLTGGFYKATIHRVVQPPRDQRGSTRLGAFYFAMCNDDVRLVPFTASPVLQRVGVVRKIDDEDAPTMSEWRKGRSKAYGMTELKRKDDVVEEQVINGVVVKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4U0</accession>
    <name>A0A2G8S4U0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4U0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4U0"/>
    <dbReference type="OrthoDB" id="2740528at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="134"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="194" mass="21708" checksum="A997A96BCD953754" modified="2018-01-31" version="1">MRLLDTYTGQFIEKDPRDPDTKYAILSHTWDREGEQTYQELRDIQKRYAPGPKRQSSDDRRHMPGNRPSVGPQQNVAPLTPSQSLLLLTLLLILLSLLPPHDTLQRTPSAKHGESSSASALSLSSAPSSPSDTSQAHSETLLSPIWDDPKLSPKIREACKIARENGYQYIWIDSCCIDKTSSSELSEAINSMYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4X0</accession>
    <name>A0A2G8S4X0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4X0"/>
    <dbReference type="OrthoDB" id="2729416at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="175" mass="20515" checksum="A48D198258033836" modified="2018-01-31" version="1">MENRPPQKKLPREMVAQNGSNPPLYHYGIPFMDQYMLEYAKRHHLTLELSPATREFFDGSPVLDFSKLTPEQEQDEELMNQLLSAAGLLARCHMQERCGITLHVARPFSLEWDGMVSLWSNYDYRDRYSRLVGSRERFNTIVAKLKEAMYEGGQENDIEWWYEWSNDVGIFTSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S506</accession>
    <name>A0A2G8S506_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">UV-endonuclease UvdE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S506"/>
    <dbReference type="STRING" id="1077348.A0A2G8S506"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="473"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL28869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="516" mass="58129" checksum="8DCFBC5AD8088079" modified="2018-01-31" version="1">MAPKRKRTSTLSAITDSGGHEPSPPLAVLPTGMALVSTPEEAGVLIRRSSTRRKKVVDYAEDKSQEDGALDGPLTELEEDELVDEEPAPKKKRRTRKKVVEPVIYDIPPVDTKETSFKGRLGYACLNTVLRAVKPDPVFCSRTLRIDTILKPDHGMDYCKELGRKNAEDLSRLIQWNEENSIRFLRVSSEMFPFASHQEYGYSLDYAEKELKAAGDLARKYGHRLTSHPGQFTQLGSPRDAVVTSAIRELEYHCQMFRLMGLDQDSIMIIHMGGVFGDKQATIERFKETYRTRLTDDIRARLVLENDEMCYNADDLLPVCEELNIPLVFDYHHNWIYPSVKPIPELIAQINAIWHRKGIKPKQHLSEPCPGAETVMEKRKHADRCKALPPDLPDDMDLMIEAKDKEQAVLHLYRIYDLHPVIHENLRPEKPSKPFPCACLDEDGLTTAPRRRKTKGKGKAAVDDGVADAVESGLVDEDVETPKTVQVMVSGGKSRPKSTSKARTSKKDQKKDGGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S558</accession>
    <name>A0A2G8S558_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08910</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S558"/>
    <dbReference type="STRING" id="1077348.A0A2G8S558"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013829486" evidence="4">
        <location>
            <begin position="20"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="81"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL28864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="406" mass="42364" checksum="6BA9F92C211E540A" modified="2018-01-31" version="1">MARFSTLLALCAAATAATASPFVVRDSPVSLPLARRVAFTGAARIVELDQARAALLKNVGHGKGGQLKRADLEAVNQLTHYTVEVGIGSPATTYTLLVDTGSANTFIGVNQTYVKTSTSNDTGNSVSVTYGSGRFSGEQFTDTVTLGNVTIQNQGISVANQTLGFPSTIDGILGIGPSGLTKGTVSGGQVVPTVLDNAFEQGAITAEAIGISFEPASNASTANGLLTLGGSDSSRFVGNINVATITGTSPASNYVGIDQTVRYGNDTPILSQTAGIVDTGTTLILLASDAFAAYKNATGAVTDTTTGLLKITNDQYANLQSLFFTINLVDYELIPNAQIWPRSLNTLIGGDANSIYLVVADLGSKSGEGLDFINGYSWLERFYHVYVPQRNTVGFANTQYTHSEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S571</accession>
    <name>A0A2G8S571_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S571"/>
    <dbReference type="STRING" id="1077348.A0A2G8S571"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="445"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="653" mass="72104" checksum="2BD9E23ED606D0B5" modified="2018-01-31" version="1">MTKTTAPYGTWTSPVTPDVVLKSSSKVSELFVDPIASTIYHIERRPAEAGRNTIVDTEKGTDVVGKEWNARTGVHEYGGASAIAYDGVIYFSHFKDGRVYRQKEGEEPVAITPENKNHRFAQFAVHPKQTHLLVAILEDHTKPQPADVVNTLVAINSEEKTVKPLVSGADFYSHPRFAPDGAHIAWQQWFHPDMSWEGCEIGVAEVHADASSIKVVNPKTVAGKPIEISAINPSWASSDVLLFVSDKHGYWNPWKYSVSACEASAVLPKPVDEDFAEPGWQLGYSFGTPLDSDGKYALFTALRQGRNVLYLVSLLHGALEELECPYVHVASMVRVTHEAAVFQGSRNDGEEQTVLCTIKDYAKPKFTPIGPGSEKDELPFARTYVPAPQSFALKDAVTGEPSHVIYYPPANPEFTAPEGERPPAIFYIHGGPTTRNPQGLSYKRLFYTTRGWAWVDVNYGGSSGYGRKYTKRLEGQWGIADVHDTVVAVQQLSSAPYSLVDPQRTAITGGSAGGYTVLKTLCSYPNAFAVGTSSYGISDFFKLAEFTHKFESQYLFKLVGGTPEQVPDVYKERSPVFLADKIKSPLLVLQGSEDAVVPPNQAEGIVETVRKRGGRIEYTVFQGEGHGWRREENIRAALEKELAFYDDVFGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S587</accession>
    <name>A0A2G8S587_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S587"/>
    <dbReference type="STRING" id="1077348.A0A2G8S587"/>
    <dbReference type="OrthoDB" id="10476783at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013768941" description="Transporter" evidence="1">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15191" checksum="67856BE4A77FCD73" modified="2018-01-31" version="1">MLSRAVVFFFAFLSLFVNSQIYAAPTREIASRQLGTIGCELARTGVSLGLSTLNGILTTVESQVTDNAALSTVIQTVLGAVSSAESAISSLGSATSASDALSLVQTNIAAVETALSSLTNSTSSDIGANIEKALEQIASTALADALSACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5B6</accession>
    <name>A0A2G8S5B6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5B6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5B6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="133" mass="15107" checksum="593CC0C518E10836" modified="2018-01-31" version="1">MSHRSDINYFKCPLAPPTVVSTKQQRYRFRQRLLATFEPRYHLDRCVLRRSTSFGAGPLLLRSVFADQIKTASLLKRINSFGTLSIGKRASAFLDCATCDDVVAKVGWQSCGLNFLRTESNLFGGKFVTFEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6B7</accession>
    <name>A0A2G8S6B7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6B7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6B7"/>
    <dbReference type="OrthoDB" id="2739487at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28731" checksum="92DCEBD24A1E6046" modified="2018-01-31" version="1">MFSLPTLACGAARPDKPVVDVQEPAAVWTHVLSFCYFAPRPSSLTIDDVHALLEAARKYQMPGVTDWMRRTLVDEFVDKQPLSAFGLACAYKLDDVVRRAARASLLLPPNFSYAKELDLIPTRLYHRLLEYRRRCLQTAQKVLSWEFYPEGPSWLSDKSNALRYNRVFYALHPSNEPGQSGPFIGGGYMINHAWRMGMEALCKDIDKQLRPSSTFWEDADTIATRAQDFALLLDAEIERVVNEVELELDNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S724</accession>
    <name>A0A2G8S724_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S724"/>
    <dbReference type="OrthoDB" id="2754576at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="584" mass="64654" checksum="103795823C6BFB41" modified="2018-01-31" version="1">MSSQLRVTAPESADDPGSSSLLPQAMDASTLPPYIPIEIVHLIMDQLYNGSLPRDHCYRNQTTYRHWSLVCHAWRPYAQALLFRIVEVTDASSLRRFAALLDSAPRLASCVRLLRVYSRHLHTPENVFACLPVVLGSRLINLRELAVSRISQDDTWHPHAQSPPLSCELSYMPLPSHFFAALPVLGTVTTLKIYWVTFETFGAFARTVHSLSSLRTLVCIQARWCLLGEPYPSTLPGPSQSAMHGKFLPQLEDLTVSFLAIHGAERLLSSLDGSSITKLYIDCPTYHSTVVTPFNPSDPWTGFGLGTDLRRFPRLRTLWVSIPYTLAIFPELPDAFATLLRSWTPRESEEGEGTRTRTLTITPTYEYDFSRGDFVDVLRALGPVVEGILLGGDGAHQHDPSGSRDRDRTQGEGPAVEVEVEVEVCVIDKAEERRRWWRGVARACFPRMHEEGRLRSTFTKGFAAYASPTEYWDYWDWKDVPSETASEVGPPGATVEDAPLPEAPAELGPHGEAGHGGVPVHPGPGHGAVGEEATSVGGCSPTTKFRWRKRLNRPVRALAGILAGVRMRLKLGKLAIVKASLHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S750</accession>
    <name>A0A2G8S750_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S750"/>
    <dbReference type="STRING" id="1077348.A0A2G8S750"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="243"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="443"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="627"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="581"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="704"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="586"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="781" mass="85035" checksum="C35AF7864025F445" modified="2018-01-31" version="1">MHDALSSNLNGVHLDSVSAPDSPAVDSVATPVNNSLVPDVKIDVDYNEQESDARHEPPPIKLDKLDNASIIPHLDTPPVPDTISIAPPPGTPPPPPAESQDDVKMSEENAPAPGGDVEMSESSGKANGLPNGQTHESPVATPASPLPAVSSSETAVDSNPASSPYAINTNANNDDDDHDKPPPAKRARKYSDAERASLANTGTPPPASVSPPPNGNVPAEPPGPSTFSIAQWRFSSSTIRTLKKMKDAGPFLNPVDPLALGIPHYPQVIKRPMDFSTIERKLSASNPSKPDPNPANLRYYQADQFVQDVRLIFTNCVTFNGPEHPVTQMGKRVESVFDKQIKQMPPPEEPKAPTPKKVATPPPPPPPPKKQARRPSIPVAPVIRRNEEPIGRPKREIHPPPPKDLPYSEAPRKPRKAKAPKNAVAAEQLKFCEKILKDLHQKQHYQIAHAFYEPVDPLKMGIPEYPKVIKKPMDLSTMKKKLDAGEYPTAEKFRDDFKLMIKNCTTFNPPSNPVHEAGKALQNLFDEKWKNLPVPRSHDASDDEDDEDEDDEDDERARRAGMEGMIADMESQIATMKNNLAALKRNGKEKTKKEKEKREKPAPPVASTSKAAPKQSKAPPAPKGKKGKKPVTDDDVLTFEQKKDLSDTISKLDGAKLEKVIQIIHDGVPEIRDSTEEIELEIDQLPAAVLTKLYNFVIRPMKPPVKRPRTGKGTGTGGLKRKSMDEDVETKKIRALEEKLKSFEQGGRASGGATNGGAAAEMSEHSSAESSSDESSASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Z5</accession>
    <name>A0A2G8S8Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Z5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8Z5"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="70" mass="7456" checksum="EF7A83C2374AAA50" modified="2018-01-31" version="1">MFAEAGSLEYEGGAANVGMIMDWREMAGRPTTRALPGEGPWKSFNSVWSGGKQVGMGSLQQGPLRSVDPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S955</accession>
    <name>A0A2G8S955_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S955"/>
    <dbReference type="STRING" id="1077348.A0A2G8S955"/>
    <dbReference type="OrthoDB" id="542931at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL30294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="36901" checksum="AC9BE0EFBAE4768E" modified="2018-01-31" version="1">MPSRISTLVQSGSRRTGPRGLARTGGEARYGNRPCAVDGDRGGMVVAALGMWMQGQYERPMKILLLARAKSLPITGMTSTFVHSVSCDDMNEYLHPDIRCQPSSSSLVGRLSSLDFTAINMWLAGTPDLKDWSWTDRIIALQTLHYLTLSFLIPPMLVMFAESGSLEYEGGAANVGMIMDWREMAGRPTTRALSGEGPWKSFNSVWSGGKQVGMGSIQQGALRSVDPVRSWIIAVCWMTASAADIYYLYALVRRPRLILDFALTLLFNHLVLTTYYAAAIPTSVFFWLVMCVSTTGTVVFAEQLCVKREMNEGLVVASTHEAEDSVEMGSLLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9A6</accession>
    <name>A0A2G8S9A6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9A6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9A6"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="374" mass="42642" checksum="35D7120ACC01E5FA" modified="2018-01-31" version="1">MPEQQPSTQPPDRMPRLVVPKHAQAKAVTKAVANEKAAIGTRSEDRKEHLRQVRAIFAEFLGAPEDEDFVSGHTPAPREVVEAYLNGTGFGPDRNDLCFSDLKPFNNAWNCAVASELGAILFARQSSGNWRRPDSTRVTAASQPYWADAVLEKFKRQATSWRDAMGRDVIDQSTGLRRQESRTEANNRRCQQAEEQSKISRQRERRAQRWERRKTICKAVLTFATTTFDKNQWTQFLRIVETLGKEGMSSDESAAEEGTHRSCYRVSILPWRRDFDAIMDKIDAERLSPRSGYSARGSRPTPRHRQDRALVSLEDADDIYFSHREPVPGLPASFYNEQWLEGRSEDYIEQVLCVSEEASDWVAQIANLYSANKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9D9</accession>
    <name>A0A2G8S9D9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9D9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9D9"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF42">
        <property type="entry name" value="ZINC FINGER, CCHC-TYPE, RETROTRANSPOSON GAG DOMAIN, ASPARTIC PEPTIDASE DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="277" mass="30202" checksum="7ED8BF14EAD4C179" modified="2018-01-31" version="1">MSNAGTTPAPPQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLAGGTQPWADFAAFETAFKAHFCAADDRKQPSQSSLSSDYTVKFNAIAARTSFSAEDKRERYRTGLPYKIKDILATSGHDTSSITKIQAVALTMDQNLLVREEERPKQFSGGWRKKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSGETTDLAALRAELKEIKERLSAVSVNETKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Z6</accession>
    <name>A0A2G8S9Z6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Z6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9Z6"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016002">
        <property type="term" value="F:sulfite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="133" mass="14826" checksum="AB91FA50CF2E2C56" modified="2018-01-31" version="1">MVGGTRRTTNPLRKHHARCRNRDQDADGPETGYKLWEPLVWKALGVDAVEVTEAEPEPITNEHIKVASQYLRGTISEGLEDNTTGALAPSDTQLTKFHGIYQQDDRDIRRPTATKRVAPSCSSRVSRSFPALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA25</accession>
    <name>A0A2G8SA25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA25"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA25"/>
    <dbReference type="OrthoDB" id="2585251at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="503" mass="54738" checksum="77113A303C4D71BF" modified="2018-01-31" version="1">MQLASSGFRALKGGGQHHLESRSGPLSRSIHIPAFTRPPPNKPSTATAQAVFRYARTAISRFVAHLTTPGTLHSSIHVHSGASGTRMFHRPATRMPTIQDRLSFPARQILSKPLAVPFLPRPPVVPRHIAQVGLGTARNFSTGRPIFQHLIENVPVYARAFNEVDWDLRLEEERARLRLEKQKARRAAKAAKKPQAPLRPVKQNVVSAPVANVVESEKDELEHYFPTPAVPEVTTHLLIPLAPTPTSRLPLPPNPPPSSSAHPLLPLDVIASLHAGHGTHALRVSTVFARLDTARIFDEPGVHCEARGDPSGLCTVLEVRFEGWTASKVRGILGEAGTGWCVLEEVWHDEEHAEAEEMDAALETLSIGESEASRNVSLSSLSDMNGSWSMSDSSIDPSRSFVLPTLDFSASFAAPTWSPAPIPPSGSSTPMSDLEFHNVWTQMESRASSPGNFGSDGDSEVGSVGSEWHELSRAPSVSDVRFGFSSQFSERMQGPDGPREEMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAT0</accession>
    <name>A0A2G8SAT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAT0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013963685" description="Transporter" evidence="2">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30310" checksum="342B7BFE8EE68D5A" modified="2018-01-31" version="1">MQHLLKFVLAALAVAGALAAPINNNSAQSHVKHVALPHSSSHSQSDPHSHSVDPHSGTHLARPRSIDPHSHSVDPHSVDPHSHSVDPHSHSVDPHSHSVDPHSHSTDPHSQSDPHSVDPHLGTQSAHPHSVDPHSQSDPHSHSMPVDPHSQSDPHSHSVDPHSGTHLARPRSIDPHSHSVDPHSVDPHSHSTDPHSHSTDPHSQSDPHSVDPHSGTQPAHPHFVDPHLGTQPAHLYFDVDPHSGIQSARKHSARTAKAFMHRRPRPIPIPTPTASHSGSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAW3</accession>
    <name>A0A2G8SAW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAW3"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="219" mass="23425" checksum="4965F1A0882E3823" modified="2018-01-31" version="1">MHILVLGGTGPCGIQLIQQSLELNHTVVVYARSPQKLPADISANPSVTIVQGELTDAEKLSSAMQGVQAVVSALGPVVTSVHPSNTPLANGYALVIKTMKQHDVKRLILLGAPSIRDEHDRFSLTVTGMIAVVATLARNGYKDLVAVGKTIRAADPKDLVWTIARVPFLTDNEDRSAIAGYVGDGKFRIRLGRAAFAAFVLGELEKNEWCHKAPLISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB43</accession>
    <name>A0A2G8SB43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_05664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL30971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB43"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB43"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="723"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="372"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="748"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="913" mass="100081" checksum="FCD27D745C204D83" modified="2018-01-31" version="1">MRRAGSTRATSPTNTTYSGISSYRTDSYKPLLRDASSKDYSVLDPRTVARTHFEELSQYLAAYLAKEPANSRSTARQKLTRLTRQQFQELSTDVYDELIRRKTNTSDNEVPFLPVRDDFHPKRNQARQKLATLPTGRFKDLSSDVYYELARRYPEFKEELPDAPNSAMSAGSNYDDYPSPDFPRNGRASEDRGNDSGYGGSTPGTSAGDAYSRRKPSQDIYIGSDRRRPSQDTTLGRRPSESASVTSGGDAQSATAGMGMIIPNKSTIAEEDIEVPYGRDSNVTARNRTGGGLSDSERDLEDDLSPRSPPERGLGGLSGLSARLQQADESEDYYDRTSYGRQSVASDRSAGAGSKMLVGGRSSVAGDDDRVRKEYEFKIATMQSRITSLERDLEDVQDREQKWLDGETRSRAMEQELGDLRRRAEEKSSSMLALQQELDALREERAREKDIAERGQRQHQDEIQILRERCEVLESSGGAGGSVDSAMLDQLQSDMEGLMTELADLSRSNDELLAAKDDDLAHIRELENQVKEYKRKYEQAKTELRSAKATSQLFLQPPKVDDQLPVARDGGLVDVHVTGFVSSVDTLLTAGRSNAPTRVLQPMKGVINAVTAIIEDVRTFERRPQRDRAEVDLEALQSLRERLDATLSNLVTAAKTHATGAGMSPVSLLDAAASHVSSTVTEIGKTIHIRKATKAEQDTFMAGASVSSSPSTNGFTPSLRAVEELRSPPPHQRSGSTSSRGVDERFNTSPSSSPRVTPRRPPSNMSSSNASSPPPLFEKSLINGSIKSGSSVPAEGPEDAWAELKPYLEAQTESIVYAIQSVLSGVRSPTPSPTLNENLTQIITIVSSIVAVCKDNLPPTSKAQGEEILRELGEHANKLSEVQTQADITKESRQVMAKSSFAVANAMKGLMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBB4</accession>
    <name>A0A2G8SBB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBB4"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="15627" checksum="2CD2BCA4D6484CE5" modified="2018-01-31" version="1">MPFGILGDVSELKRGPGKHFHIVLIPQPSDDSRGDPLNWPRLRKEACFWVLLVVSSAMRIAYLTGTHGANASHILALTEFALSLVSYGVTSFANGVVLSAGVRRTLLVVAVCQAACWATCVPMYVFGKRVRSFIARRPRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBM6</accession>
    <name>A0A2G8SBM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_05838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBM6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBM6"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="459" mass="51030" checksum="99810C36087256CA" modified="2018-01-31" version="1">MAFGILDDHKLDNVPGTGLLSDKTSNQMTAEEARGLKRGAGKHSHIVLIPQPSDDPRDPLNWPRWKKEACFWTIVFTTTVSDALWSIARPAYVQLSKEFHVSIDEVASSFSSNLLGFAAFTLVQNPFAIKYGHRVVYIVSSLLLGFWFMSIACGLSFVAVFFFAPETTYKRNSVVESTKHSDVQIHNNDSHRHGVESLSPATYLSQLKIYNGTFSNESVFKIFLQPLPFVLSPMTLFALICYCIPTSLLALVSQCASTIFTIEYGFNTVQIGLTSLTGVVGIALAMLVTGPFNDWVIIQMSRRNRGIYEPEYRLVFMHSMVIAVLAYAGWAIGNDRHMPWIGAAACMTMLYLSVFISWSPPFTYLIDTHGTNAAHIIVLLKCAKNILSYGATFFANRVILAHGVKATLLVFAACHAACWLASVVMYVFGKRVRSFVARHPRLFGGDLPERDLPQSKSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCS3</accession>
    <name>A0A2G8SCS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCS3"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="65"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="443" mass="49170" checksum="D199DF16593A75D4" modified="2018-01-31" version="1">MAKPYQPTPEDVAKAEQRRLKKEQANLNLAPKTDDEPSAILPREWLEISISSQTANTSGQMIRLMTWNLLAQSLVRRELFPTSDCLKAGQREHMIYKEINSLKATICCLQEVDRTEKLFPQLEKAGYAWVYAAGPRKKHGCLIAYRKDAYQCVRQKVVAYDDQEVRSEGDGQARRGSSFRTKNIGSLVALRRLQGDDGIIIATTHLFWHPAYTYERARQAGILLREVTSFRKEGTVVEEHWPCVLAGDFNFGPDDPAYSLLVGNELLPVQKARIQSSRVVHATIDPSVSTSGAAVAEEEEEGAELGENDPDRITVNARAAQPSDGLLSDAELKGLFRQSGTPTSAYDAGQRLYPSAGEHTFGSRVPIPEGRCGAFEPIYTSYTHYWQAVLDYIFILDAPGSEVSVVRLAKPYSKESFGEGLPRKGICGSDHISLAADLHWPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCT0</accession>
    <name>A0A2G8SCT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCT0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCT0"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013607415" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="847"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="39"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="221"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="362"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="507"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="895" mass="98204" checksum="7C96E3EC87590DA9" modified="2018-01-31" version="1">MRPWSSIPIGLLAFLPLVAPAQLPLPLPLTPEAAPTIQSFTLLDALYNDTDYVFLIKLLQRARLIPTFNRLNGSTFFAPTNDAISRYAASNELWQLALRDDTQELHDNIQLQLRQQLFYHLVNYTLPLLPSEQTPQEHDTLLYPRETAGPPSQEPPPSPPWMPIQNGTLGTDPQRLRLSARDAAIWAGVDAFGNSGAKIVKDHVNTTNGLLLGLDAVLEMPPDLATVISRHPRLSYLHKILTPELKTFLNSTPTLSLFVPVDDAWNALPELQRLYLESEFASNDMERILNMHTVVDGSQQVKWSDSFRKPTNLSTIEGPDLKIVPTDSKVKVSHAELVEHDVYASNGVLHTINSLLLPPDALKVTPEKYLLTLNCTQFVSLIHSVHLTHLINDTEAKYTILAPRDDVIKIFGHDGLPHRGSEELKQFLQYHFIPGKWSPEKFENGMLVETVLEEAGLEGGNQVMAVEVDQNKASQAKAIRFAGAGVMDEVKINNTVVYFITHTLTPPVDVLEAALPNLDFSTFLAAVFSTNLAETLKTTPRTTILMAPNGAFTRLGVLVSNHLLSSSGKSDLDRVIRHHALLGVHYSDPLVNGSQRTFKTLEGSDVAVDRIGANRSVIFTSSGGWEDLQSGLQPMNMLTKTGVVHQVSDIMIPRSVHLTVGKLVKAAKGSTMSTMIQKAGFEWVLNGTSPPEGSKWDEMGLGASGWTLLCPHDDAFNNINLTELYSDQTRLEAIVAQHLIPTATAVPVEPHEGLIDTVVNNRPLPLDDSATYSTLQSTASAYGDIIIRVLGSKDGPQGTVIGIKGARGENGEQEWARIVAWGRSTTGSGTGGVVQIDRLLFPYAPSWYVQYGAPVGVGFGGVVLIGLFFWGVRWVWRRDTTEATYEPIGGFGSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD54</accession>
    <name>A0A2G8SD54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_06393</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD54"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057106">
        <property type="entry name" value="NXPE4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF1">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24536">
        <property type="entry name" value="NXPE4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="NXPE C-terminal" evidence="11">
        <location>
            <begin position="62"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="10">
        <location>
            <begin position="315"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL31690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="870" mass="98317" checksum="36DC0AD97AC8739C" modified="2018-01-31" version="1">MPPKRFQFSLNPLWPHYLSWASVAIAVALGLLRYGVVDRPDPLHCNALLAEGRWLDAKFRNWQPHGCMMYQYQAKDVSTCLKSRRVVFIGDSVTRQLYFQFAHIVDKSLPSGPPDDEHKHMDYTFTSNTDVQLSFHWDPFLNSSNTNTLLRPLGRTSPSDTPALLVVGSGLWYLRYAQSGGLPAWEATMESVLGAISQAHHPLADRVVVLPIEDVISSKLSADRAASMHASDIDAMNSDLLHRIQPAALRDPFSFLPIPIPRPIGMPVSLPLVFNRMLHPSQTQDGLHFFDPVVGMQAQVLLNLQCNDILPKKFPFDKTCCRSYPWPAPLHLLLLAGIVLWGPANWLLARRFNPRSSGLPLIKDDEIPAIVFSFATATIFLADRTGYWLKEQKQFDPWLFAFLTLLSLALGLLTVTRGDKDLGFLNREQTDEWKGWMQIAILIYHYTGASKVSGIYNPIRVLVAAYLFMTGYGHTTFYIKKGDFGLLRVAQVLVRLNLLTLLLAYTMNTDYLYYYFAPLVSLWYLIIYGTMAIGAQFNDRTPFLIVKLLVSMAVVTMFMSQQWLLEVLFQFLERFCAIRWDAREWAFRVNLDLWIVYFGMFTALAVIKTRDYRLTDHPLWPLTVKIASGVSGVVLLWFFAFELSQPNKFVYNGWHPYVSFLPVGAFVVLRNANVILRSGSSRLFAFIGTCSLETFIIQYHLWLAGDTKGILVVLPGRHSRPLNLLLTTIVFVYVSHLVAKATGDLTNWICGSSKNTSLPTASQQGNGHGSQRPEVVLASQSQQSQEVIFMVPQGQEEEQKDRNGSLLPPEADTPSRPPPRWIDRLAEGSMTTPPSSGLHVWYGESEWKPGLKTKLLIGVGVMWLLNVMWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD76</accession>
    <name>A0A2G8SD76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD76"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD76"/>
    <dbReference type="OrthoDB" id="2751906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30064" checksum="9149AED26FB9D7B5" modified="2018-01-31" version="1">MSSTDVDAPRQQGLRVSFDPDNIFTLQPVSSSYPWSEVTVIDEGGRPSILTEYGTPWVSKSDGARDLYRGYMEQFTHEGGERIQALREVALRWVVGEAQLDGIANEVRLYEQELVPLQGTVVPKFFGFFKGFVGKNKVGCIVTEWCRGVQIGEEHELNRQRMLSAIELHKAGIYHGRLLDKTHWVSAGDGTLRIVGFSSAHIHDCEGMTVLSKDTGGDPRPDAVCKELAVLESRFGVDAERDGNYVRWANNMYPDFDTSFYLVYSFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDD6</accession>
    <name>A0A2G8SDD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDD6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="159" mass="16747" checksum="C62E8561310C1746" modified="2018-01-31" version="1">MPIGADRCEPATELGHGLIAHDGAHALHVGKRWSQTSKDRVDLVTLDGRAFVKGGDRIPAEGNGKGCSSGLAECTKRKVPRCAVSEVDRAPEGTMVQRDAPEASTGGCKDVASGMVVLHGSDRWGEDDIGEDHAEDLVGKLANAEERASQEAMFPQVAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDJ9</accession>
    <name>A0A2G8SDJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDJ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDJ9"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="342"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="345"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="485" mass="53193" checksum="C6FBD839323DACFD" modified="2018-01-31" version="1">MAPHLAHLLEHDPSFFDDYRAMPPPLPNHLAAIHFPIDGTQIDPQLMGVVGLGPPGVPYPGHTLDNRPMSPDNAPVTKNSRSRRSSRKRSGISSSGADAALLDEGGSAAPSKRRRSKKKNAEGNEDVSEPPTKKQRLSGSESDRPRTRQPSLPPFDPEADPGEELDPTAVTMATLCDDTGRGRVSTRAAQIVSNHAAWRTSNREKRARMKAIMEARKYGRNLDDDEESAARVAPDSQTGESTDPVDPESASRSGTPAVDEGPSRRVDGATNDEGGTGVGGFDYTENLAVSRYNVQVRIGANGETIIDEDSLFVNRDEEHHTEDYTHVEESDFTKFVNSSTYSKKARGSRWSAEETELFFDALSQFGENYELISYVLPGRDRKACKNKFKSEDKKNPARITFCLTNRKPYDIATLARMTGKDFSGPTPEIRAPTPVRSTELLVDEPTTASPRPVRKKSRTPSVRDADVEIVGGIDEFDKDDVGIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDN2</accession>
    <name>A0A2G8SDN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06584</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDN2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDN2"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="171"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="722" mass="80932" checksum="39CA1FCD8A8273E3" modified="2018-01-31" version="1">MSDPRFARLKTDPRFRRINKDKNKVLVDDRFQHFFDDSRNKKNKKGNARVDKYGRPLADDHEQDNLRRFYRLEDEDEAHLELKPGPDYARGEVLLESSDEEDDRQPGAHTDEESDSSGIITLGRDVNQPIPVPDDAEVNLDEDTFADLDAQAAAYAQANPVTDQDSQVQHTRRIAVVNLDWDHVRARHLYKIFASLVSPTGAPVASGSKNNGSSKKSSGSVARGKVLSVRVYPSEFGKERMAREEKEGPPSGIFKKKCDLAPEEINERTVYEVGEGEDYDENALRKYQLERLRYYYAIVECDTVEAASHVFSELEGTELERSANILNLSFVPDGMTFDDDFRDEAKDDLSAPYKPLEFVTDALRHSKVKLTWDEDDPDRAQVTRRVLSRKEIEENDFRAYVASSSSEESDAEAASRDKRKTKTKAAEREKLRALLLGGGDDAMPEGWGTGTGKDEGNVGMEITFTPGLSAGTGGKDETTLEKYQRKMKDKKKKRKEDVLGRRQERDKERVEGNSAKNDLDDDFFGGDSDEESAHEVKVEAQRGKKGTHKDKKGKGKGKGDGEEDDPGRVESTAEELALLAASDNPNGEVKHFDMKAVLRAEKRGGKKKGKKGRKSADDGENELQEDFVIDVKDDRFKAVMEDHTFAIDPTNPHFKSSKGMAALLDERTRRQHEQTSKNRESTVVKGANADTSQPSLQSLVESVKRKSVAMEASGMGKRRKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDY0</accession>
    <name>A0A2G8SDY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDY0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDY0"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="165"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="356"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="741"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="757"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="871" mass="98695" checksum="5B1B58019946ED78" modified="2018-01-31" version="1">MDKEFYVSVDLYVSAKAASALRKPPAKKGSEKRDSTRVVPANGDSSQRKVKEKSSWLSLARSPGGTGQWRPARCKLVEEEEGCLLNIYVDDTILYRSIYMYLLNHTDIRLAHRSLFDRRNCIAIFTVAGQVRGAAPTTEPLYIQFEDEDIANTWLSLLRSYAMPEVYGRWLSPEDGGLYRMWRQVDLTCLQGRNLGVTRPLSDDPSGAEQEAKAEADAIDMDVYCEIFVNGTICGRTTVKKGIGSPDWHERFQLTDLPPFENLEIVVWREKRLTRPCIIGSVVIVLVNFRRGDSVEGWFPVLNGGQASSTQAGEMRLKIRVDEEIILPYHAYSRMLRTLHSRNHLDWMRELETRLKMKNVNRDIMSIAIAKNALLDNIMELADREVDGTLTSHNTLFRGNTVFTKTVELYMSWYGMAFLEASVGPSIRRLCAEKVGIEVDPVRIGKGGRAIEKNVELLVTWCQEFWERIYDARRQCPPELRKLFEHIRRLVERRYRVRDDSNRELPWQSVSAFCFLRFIVPAILHPHLFGLLPGLPDATVQRSLTLIAKVIQSLANLNPTVQKEEFMRGVKEFLTNGLQAMIDYIIIVSTPESKAPSTPLSTDKHERLRVIHALRQRTATAPVLHREAIPLLPHLLDIPRHLAVITSVVVRFSRTQNFHPTQQINPEDKYFSEFCTRCLEVEEQALARVSKLAAKPRRLHSEPAINVPTPLVPTSSLPISPIPISPSSAWKLPTRERKLSASFMSPIKRSRGRKSSRPSTAPSSSDRGSESSSRQSFSSGSFAEPRSATYPHPPMPLPSSLPLLPVSPPAFDDHLRKRPTLVHHPRSTSTDSPLARKSIPEPLLSPMSDNSADDDAGKRRRNIFRSILTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDZ6</accession>
    <name>A0A2G8SDZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDZ6"/>
    <dbReference type="OrthoDB" id="2575000at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="235" mass="24560" checksum="E54F276F62099945" modified="2018-01-31" version="1">MIAGLSKAFHLYLAPLLLLTSFILVLFSYLAPVILFPTQVSLLQVSPSTALTQSKSSDGVDGPSIFLGALGSCARSKNDASVACTPPTVSPTYDLSVLPSSAPDLLSAPTATTPAFIAVSLAFTIIFFILFTLTSFRGKMGKFGNALDKPGVQRATAWIGLLGFLIGITSFLVIRMWFGKAVEDFNAGIAKAGSDGPQLIASTSNGFVMVWVGFAFYAVPVVCSLAKLHVAAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEE8</accession>
    <name>A0A2G8SEE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEE8"/>
    <dbReference type="OrthoDB" id="3267487at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="433" mass="47022" checksum="8EA5070C9252B95E" modified="2018-01-31" version="1">MEDACLARHNSLTGAYSPLWPLRPTCFFICSILAAHALLRFPVPFLPALRYLSTTFLCTIDRCSPPGEDLEPAPCPPLAPHPPVMSAGYLTLSRPETTTAPLHATPTTILHASSAIVTTFSEANAIANAASTYATSCTGLSSTPTVVHVVIHTTVTIPDFYRYYKTPLSSFQPQYTALDDGSLISSVYTPNLRVSEGWLVMGGALIVFFMLSTYRAIQYTRVVKVKNKGLFYMLIMSQLIGIVVSVFFVLADFNTDIDCTATGMVKKGGVLISSTLLVTGILGTKAYRCLSNAGFVIVVLAFLRAAVVAVSGVVLAEYKGGRRFTGTCETVSESPLLPVSIVLQFLEAFFICICFMSAVFRSYRGPANHARLSLPLEEDETSSVGSNDKEHDGAQVRTIRGWWDYVPSPRGEKTTATPAPLYVKCRLARVNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFU5</accession>
    <name>A0A2G8SFU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFU5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="116" mass="12517" checksum="71F065FA5709522F" modified="2018-01-31" version="1">MDSAAPISAPEPFSSHKDKEKANSSGEDSRSGISTVVGPVDDRLATIGEPVDEEGNAFPDIQEDGKPDPFEVRMGPNDVDNPLSWSKTYRWYVTGLSALLLLNAYVPNRVPPSADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGE9</accession>
    <name>A0A2G8SGE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGE9"/>
    <dbReference type="OrthoDB" id="2804045at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="325" mass="36656" checksum="86A51A92D0995071" modified="2018-01-31" version="1">MSTVQISPQDMSDIYTTTYCVYACGVLLVYDWLLCFGKEVKYIWKWHSRVTISTVVYAVCRCAANQWTQVVTEILAMIAIWAFSGLRAYALSSRALWLTTIIILWMLPPTVIFIPYKLLLVELAAFGPFEHDIVIELLAVVVTWWYSFQSYRIRKGTVGLGKSLSSLLIYNGSTYFLFLASLYIFDIIVRTAPVPESVAYVTGFMELFYDPLASILVCRFMLSLRQFDASVSYATELGTDSRLRDHTASTVLRFGAQPSESLPALIAPFAHPVHVDWSQSETEPEAVSDRGSEWRETDVIGTETETLRSSDRTPEGQLAKTEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH69</accession>
    <name>A0A2G8SH69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH69"/>
    <dbReference type="OrthoDB" id="2751943at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="628" mass="70814" checksum="9A931EDE2419C0AC" modified="2018-01-31" version="1">MSLHSAATILPYPELASALSEGDAAALIKLSNASQVWAYEKYISTLLAIQGSITPIDDLPPEILRMVFAYVPSEQVWWDETAWMLSLQLVCRRWRSVLLATPGYWVQGIDRVMDLYKRDNRSLLVSDSTEEDTRVQVLDLFLNRSAPYPLELTMAYMSEARCPGWRAFEKHLDRVTVFEVDAMDAADLQENILPAVTTEMKQLESLALDVDHFNMSTKGLDRWEAQNLPRLRDLTISSYLFCRATTVPSLRTVVLTGERYIESLSALLPALEGCPALATLSLHLDSNHRRRKGNKRRTPERIVDLPNLLHLNVAGTTSEIYSFLSFVSFPSTTHIQLVVNNVHRVEDPLLLLPSMLPRHHWSAYTSPNIDRLHLHKGTPRWLYSHGGCVSMRGYIQGNERLSIVPALGSNVDADGLVQFLNTFSACTLTELALDLRSRYHTSPFWASFFAALPDLRRLELLSQATSQYPDPELRKINLTIACEFLKASKGRLGTSLAWVLRAFEGCPGDLDQELWDVEMALSYLAEVGGHLERLELYIVTPTSKDLFPYRDPAEPIDLKQLATNGTASRSVARAYISRLEEAADVVVISGGWGFLEDDEQDLEAYINDDEDVRTWRTRKTVKDSGNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHI7</accession>
    <name>A0A2G8SHI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04661</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHI7"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="262" mass="27603" checksum="BCB95AAE3A338268" modified="2018-01-31" version="1">MSNPPVDFPLQGKLALITGCTGGIGQATARAFARAGCSIAVHHSSAKSLPKANALVAELVKLAPGVRAAPFEADLSSYENARRLCDEVVDVLGHPDILFSNHGVTGPKIGPQGDMQEVSAETFEEIWRTNAGTGYVLAQKCVPYMQEKKWGRIVFNSSVAAGTGGVIGPQYASSKSALHGLIHWLSLRYCKEGILTNGVAPALIEDTDMMANPTQAARSLIPIGRLGKPDEIASIVLMLVTNGYMTNKIIVADGGWTNGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHJ2</accession>
    <name>A0A2G8SHJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_04695</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHJ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHJ2"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013748623" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="18"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="203"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL33245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="558" mass="58791" checksum="F6458A299F8FE536" modified="2018-01-31" version="1">MVASGLLLASLVTLALGKPATRNLKLHEAVRGAPSGFSLTGSADPNQTLKLRLALVQGNVTELERRLYDVSTPSSANYGKHLSKTEAHQLAAPAQESIDAVNSWLKENGITAQTTTTTGGWLSFEVPVSKANELFDADFSIFKHDDTGVEAVRTLSYSIPAELQGHLDLVHPTVTFPNPNGHLPVFKTPVKSKRQVDASCSSTIIPACLQSLYNIPSDAATQSSNQLAVTGFIEQYANQDDLAVFLKQYRTDMSSNTTFTLQTLDGGSNSQTHIPGFEANLDIQYTVGIATGVPTVFISVGDQYQDGDLDGFLDVINFLLDEDEPPYVLTTSYGQDEHTMSQKLAQNLCNAYAQLGTRGVSILFASGDGGVAGSHSNTCTTFIPTFPSGCPYMTSVGATSGINPESAASFSSGGFSNYFSAPDYQSSAISSYLSALGSTNEGKFNTTGRGFPDVSTQGVNFEIMVRYTLEGVSGTSASSPTFAAIVALLNDRLIAAGKSPLGFLNPFLYSTGASALNDITSGSNPGCDTDGFPAKEGWDAVTGLGTPDFLKLAAAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHY3</accession>
    <name>A0A2G8SHY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHY3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="259" mass="28008" checksum="55E9EA12800A53B1" modified="2018-01-31" version="1">MPSTYLGLPALPSPVEIDQTAADMLTDFVIRTIQLHPRRARDDTGPEQDKAAAGDTSNSSGANSESEEKGDGEGKGEESKESVQGRGGGGEAAVEGEAKGARIAADGLVGADDLDGTEVMKKFHVLLRGVSPFLCADTLFVQLLRFLERESLLCAEEAAVWKDYYTFLSRRRQMSTAMGEVAGTLSRIRGVNEARARARAKQTAEGGEQADAEMADADVMLSALMQKLEFDTTRNRQAGEEMMFVAKNGTFWGMKVEFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIH7</accession>
    <name>A0A2G8SIH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIH7"/>
    <dbReference type="OrthoDB" id="2734493at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="28878" checksum="A8D5F183CF7557B5" modified="2018-01-31" version="1">MPLIDSRNKVIFGEINPEKRRCQYLFCQSFRKHKACSKCKYVRYCSPECQKADWPNHKKVCGRFNTPIFDAAAWRDNYENLFRWAAMHALEAHWKLSKIRSHYLLVHVLYGDHLVGATPSPFEVEAVEVISHAELRHIAHWSGDPDGKDVAECRKIQDEGGLGQATVLFRFPPPRAYMDAMKNPQNCYLIRERYKLTERRDPSTPRVASIEQVEETVKRRINGAPLPGMLDALSAMLHNQAISTALEWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ84</accession>
    <name>A0A2G8SJ84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ84"/>
    <dbReference type="OrthoDB" id="10472341at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="138" mass="15769" checksum="D0AFB38B25A285CC" modified="2018-01-31" version="1">MPRAQVPEEARLYRMTPLAPNPLELFAGDHMPTQDEKWRVYDDMVNIYGCTGYTRRQHSNWCMDHERNRLKSPRPLIAARLQVMPNPTAIDVARWALELNIADVDAFRLVGALLPEGVKAQAHFKHALYHTQVAPGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJP4</accession>
    <name>A0A2G8SJP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SJP4"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="1187"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="877"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1595"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="757"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1595"/>
            <end position="1616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1712" mass="185748" checksum="CDB1F5850905EFFE" modified="2018-01-31" version="1">MDHSSAAEQRATAVAKLKRAASLPRMKDGRRPPMHVEAVSEGERSQGEERDVRDGQEEIERGRNGREGKSSEEESANEVSKGKDDGPGARSEVEATTDVEAVGESLENGEFRNEELDGEEGEGPPSGAAPPGEQVKTSRKRRSRSRTRSRGSKDMKGKAMAKHSPPFSSATNESSADENYTSGPGEDPPPSPPLLSPIPSHLAGFQASRFLRSPITPVAPLFYPGTSPSTPLPSLDDIQKSVGAGLFRSNSAGAARAMAMSKLTGEPLDLTFISSASPTPSKLTRNNTVAGGERMAARRMLLNRLGNRINNQTDGDQTSGGEEAPPPPLTTSKRRRRRSHRRSSSRASTVVDDRDDREPSSTTPNTPLVPPSPLPLFFRNTPEPFFRGTPEPPRSGSSASRRVNGEAERVSPRPLPNDNAPYTLGHRGVVIEDEDDLPDRVSPIRPPTLPTTPARTHRPLVGPRLPHTSDAPSNASTDSPGAITVPMFLSHNASFRQDLFPASPFQTPLKEPVYPDEDEVLSPQDPRSRSRLATATSAFDRDSEISWVDPDDEDEDDDEDEDGEENEEEDAAEHVPEEEADESFGDVAQRSSREFSPQEERPSAPKPLIVDVETSPEITPAHVPSSPASITAPSVAAEQQEAGVPPSPPTYPMRLSVARSPSAAADYTDFDDSRAESTPKRQGEGVSTWEKMKGAFTRSGSSNGRRSRTNSLSARERRYNTDSSVSRESGASLKLEKESPGTGVFAMQQAQPPLMQSTSASTSILSLAPQSAPPGGVSPVPPASSADLLKYQDSKLFPFPALRQLEEQRRARGLTPSSSSPDVASPTNGFPFPLEQVPSTASSSGATTRVADGGRERKLSHQASDSRLWAKYSHTLMSPTDNLNTPPPPVISPTASNSGSLGKLPMNREAVRKWLSLFKSQPSTPTVAPPQVFLQVDPHSRIGKKPSLSDLLQRKDSELTVQSWDDVSSDKSRTPTNVTSAQRFGTPKETPQTVDNNLDSQPRGDADMNVPTSGAASPAYVLSDYSSPGFPSPPHPPSSTTPDPQSSLDDFPTQSTSESTMSSSHHSPDPPSNDSSAGAIIMERLDEILGRGSKSSIWPSAIDDPPRKLVMTSPVLQVANANTVKDRFLFLFSDILIIAKPILQDTDALLEATKPSPLDRKYVVKSIVQLKELRFSGDRDDTRSKTSATSNPMRHPVMQTFVNQFAKDPEHAISALLGKTSARDDVAVGQLLFRATDLDRVRLGDYLSRRSSKVALKSFVDSFGLTGLRIDKALRVFLQAIHIPSRATAGHSSALEYLLDSFASRWYEANAAIVAYDKDLAIRLVRAIVQMNEVMHGSIAAEPGITGYPKRNVIARDFVEAFRRFDPRNLVSDDVLDKIYAAVRREKLYQARHPSSVAKHPDVVINIKRPLPPRLTYRIQSEPVILRIPQPDPQLTIQLFGQDLVFEPPVLTFSKSSEVSFRVTGTALGNKTIVMWRSGPNALAYSGLPLSSPVVIERSFMRNTFQIAFLNHTGLKRRYMFSVDDSLVRHQWTVAIKRQIEIASNSQPSPTTSRAAEALAFKVLQDTLISSEDPNASFSASYPSPIDQALARLNGANRSRSGSVSSALGRSGSRRLAPAAHVRSKSRSQLYRQNGAGKMESELDDSDEPRFTDDSPSQRLWSGHDLQVVCRQNSSIPFVLAYLQVGLGENGHAQAHALPNGNGNGNGNGTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKL5</accession>
    <name>A0A2G8SKL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKL5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKL5"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="77"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL34287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="452" mass="51941" checksum="3E3BEA6222F72DCA" modified="2018-01-31" version="1">MAGFLRVSETRIVDDEGKEVILRGAGLGGWMTMENFISGYPGCEFQIREVLAEVIGQEKSEYFFDKFLEHFFAEPDAAFFKSLGLNCIRIAINYRHFEDDLNPRVLKESGFKHLDRVVAACAKHGIYTILDMHTAPGGQNGGLVWLWTEIAKHYKDETWIAGYNPMNEPADPRHNGLVNFYDRVDAAVRSVDPYHILFLDGNTYSTDFSGFPDDAGARWSNTAYAIHDYSVYGFPDTPEPYARTEEQRTRMQKSYTKKRAWMDERGLCVWNGEWGPVYARPEYEGDATDEINERRYNVLNDQLQLYAKASVLCTDVKATLTGMVYVSPETAYRQHFAAFLGHKYRLAADSWGADDKYVRHAYDPIVRLIEENVPNEEHRKLYPYPVWTVRGRVARVARCTLISEFLVREWADQFAGLSVEQLDRLAESFKFENCMERDGLNKVLREHASQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKX7</accession>
    <name>A0A2G8SKX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKX7"/>
    <dbReference type="OrthoDB" id="3466517at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="29"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="379" mass="41952" checksum="A25E4EA55A40C683" modified="2018-01-31" version="1">MASNESTGQRLGVFHDTGAPEGSADYTTLVIVHGYVWHGGVFTRLLPLAKEYNTRVILLNRRGYPGSAPYTDEELASFPELPPGDVIQEKVDEAGKKLDVWMRERTYEILHFLEDLVKADSIPQTQPGKNVGGIVVVGWSFAALMALSIVSYGPTFPANNDVDLGKYLRRVVMHDPGLGVLGYIAKEGTYQPALDVSLSEEQRAAAFDAWIGGYYAHGSTLDSLASMPLAEPPSTISTLSPEEKVAMTHPFPDVTVLDLKVTELGVRTGLTATLRERALYDKNKLPGRQDGGSANKLEEAGDGPDTWREVELRLVWCEKSVMQVPYGMMLLGLELEEARKTGAWIRDVRIVRVKEGNHFVHWDHPALAMRAFLRDELEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKZ8</accession>
    <name>A0A2G8SKZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_03949</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKZ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKZ8"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL34238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="379" mass="42690" checksum="7C6062A780FDCDBF" modified="2018-01-31" version="1">MLVSVHVQRLCARAPLRPSARAYSSRPPLPPLPPQDQWRKLFPYVNVARRDRVFVQSPQAARAVAQSLFRSTPTTSGKGKVVVEAFPGPGALSRALLELPESTVRKLIILEDDPAYLKYLHPLADADPRVTVVPMSGHNWDTYSHLDENRLLGDVEVAPWESSIPDLHFVSHLTHNVHGEQLIAQLFRSIPERAWLFQYGRVPMSILMSEWVWSRLTAGTGTIRRCKLSVIGEATADLQDAFDPELVAPYEAHFFPPLSRGKTSNRKAGQPIYGITAVPYPEQIIQRGTTDQWDYVLRRLFVLKRTPLKDAFGSLAPGATTLIKMLSDGTIPLDQRVNLSKRVNELNIADWALVNRAFEAWPFKPQDLMINDGFMPEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLD0</accession>
    <name>A0A2G8SLD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLD0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLD0"/>
    <dbReference type="OrthoDB" id="2767786at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="549" mass="62235" checksum="44BD278147583AF0" modified="2018-01-31" version="1">MHLHQLPTEIILMIFHDLYNSLDFPHIRPIRRKDVKPELKFMLVQAVCRRWRDMIRGTPYYWRVINVYSKQDWLRLCLARSAGKKTPTSVYFRKFNIPPPLLQLLSLPSHIPHIRHLSFNVDDDHFDSLRHFFSRQFPNLSTLELECPTHKMWMPSKPLSLPSHNLPRLENLVLFTTKPPEDLGVYTNLHSLELSAVPLDVSWDTMLEVLNACAPKLERLGLVHILSDVSVQPDLHSGPSPVTFPRLKMIHVANKLPYLARILSHFRVPAGIDVYLMDNIMGRQADEVTALEQAFIPMLPPDPATIVPHFSSVMAVRYTAWESEFTFIGTGEGELGVHLELYRHDDDPPLAWGSLGRKGLMELLGLLSRADVRLFEIAVDYDTLGADDFEAVFKAFPKLETLNLNGGGSFDYILELLGSKARSSSIAPPSSSADEEDKAPEASEAGPDSMWCPNLKAVIIGDVDDQWSCDDDLLDKIVQVLRARAQRGLRLDRFEIRLLHNTEEEYLEAQAKYLPQLQALVGEVVYGNHKPDDGDCSTCGSDLDSESEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM49</accession>
    <name>A0A2G8SM49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM49"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="173" mass="18400" checksum="C3CD4C5FF6D75CD3" modified="2018-01-31" version="1">MSRVSVYAFPRTLATTGSTRSTKVLSQTKSYNLRRTQRKVAATAADAQDVSIPTLQPLIQTSLPRTGLLSKPADPGSIQKRRELRRPIGLNLQQNHPSGRVAGVRGEAEIKLLGSATTGRTWTTTIQDLAVAPRVAVLPPSLRSSQFRAGSDSDSSGAVQAVQRTAACPAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMB4</accession>
    <name>A0A2G8SMB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMB4"/>
    <dbReference type="OrthoDB" id="10641133at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="180" mass="20393" checksum="27B0C38FE81C5EFF" modified="2018-01-31" version="1">MPTVVRFMINIDPHYHEATFDCPYQDITANDVLDVAPRVCMDFYHLQTSGLPPPKELARRETYRLHYITDQATAFNLDQAYQARYDIRPAQRSNPDVLKQALGWYRAMGHYLTSEYTEPTSKLESKAPPDTTVVRCMISPKSNRTPPLSLPNGNPQSHPAPFPPKRHARLRSASSAPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SME9</accession>
    <name>A0A2G8SME9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SME9"/>
    <dbReference type="OrthoDB" id="2766701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="478" mass="52314" checksum="6609F164733CE97C" modified="2018-01-31" version="1">MAKISRDVAEIELAQNGMVDGHRTTLSISDRLQRLRQCSSKFANGPFDHEDLGAHPDYLIHLRNRRWNTTVHDDRSSSSLHSQNGRSDLSLCVITPGSTQGGIESSLSLLPTGTASRQGFIISKWAIDGTQDLLVMAERVDIMLPQQLPPGSVLFFMRMHTITHLTYFLAGRPLTRLQGYLQYVGPALVNVVPLGPDCPYFLVVPRAPAAGFDLAIYNFSPSSIPGGPICRLQLPPLNPGERIAWHDIHSGDRPLHTSEGHFHADLSLSLIALTLGIMSADAEHEHGHENQAHLLIPRTTLLAHARAADSVSRQSADASPGIPRRVPWADWGPQGCLRLRQRPPAGLAARRVMLIPFGARMPLVVFDSDEPGLDAKSVWVYVFDLNPFLPRRCRVPEGTSGTGPGTAGIIEDRDIEAVLPGVVDPACASIRYRAYRFRVGLPAVPIGNRVRLVVMGMTGFTMKLSGVSYEEAVQTWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN32</accession>
    <name>A0A2G8SN32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN32"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN32"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="740"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1103" mass="123355" checksum="FF5E2869E933B374" modified="2018-01-31" version="1">MGRSEKKPRRWVVFGDDEVALNGVEGTFGDDDDREWLAAWLCPALPGATLSYTISNSTMSTPPSRNSAHADTDATGHLQVPGQHADVIQRLKNVPGYTTPVFKGKEEQRAKVQATVAAKGFVPRELVPNEVNWFYTHLGIDDTYFQAESVEVISDHIIALFGAKVLAYTKHDPSKLVIDLEKIDENGNGATFIHTSSPGMTTTEGPGSTCESRIDELFLDPSTPVNAYRLETYRSQGSISATASQQLRCYFVTKCNFPAKPPASTRTDGKTDIRTVADPIFLEKASENTLEIYQHVMWSVQQRYGPVIEVFEVEGSRERRVVIGYKMGGTKKFFSALSNLYHFYSLYSARKYVEQFSNGITIISLYLNPLPGANAPPIEHSIFQVVKEASLLFCLPDNPFFYAGKGPSGDHAVQEATYAYCGWIFAQHFCNRLGQAYLALKNILDETNPTHASVLNDIKRRFREETFTRESIAQVIHAHAELINLLYVNFAMSHYPETDEAAQLMPTLSYQRLRTQMPLSDEELYDKIRRTVTNKHELQVLESFLIFNKNVLKTNFYQPTKVALSFRLAPEFLPEVEYPKKPFGMFFIIGGEFRGFHIRFKDVARGGIRIVMSRNRENYSINQRMLFDENYALASTQSLKNKDIPEGGAKGTILPSLGENPKLCFEKYVDAVIDLLIPGQTPGIKEKLVDLYGKPELLFFGPDEGTADLMDWAAMHARARGAETWWKSFTTGKSAQLLGGVPHDVYGMTSLSVRQYVLGIYKQLGLREKDITKVQTGGPDGDLGSNEILLSSDKTIAIIDGSGVLHDPVGINREELVRLAKLRKPVGFFDTSKLSKDGYLVKVEDQDVKLPSGEVVLDGTDFRNGAHLRYKADLLVPCGGRPEAVNISNVSALADAEGKPHFKYIVEGANLFLTQQARLILEKRKVVLFKDSSANKGGVTSSSLEVLAGLGLSSEEYTENMIFKEGKPSEFYQSYVRDIQRIITENAANEFGCIWREHARLQGAKPRTIISDELSSKLNELQEELEDSDLFDDEPSRRGVMQRAIPKTLVDKVGLDALLHRLPVPYQRALFSSYVASHFIYKYGVNASSVDFFHFARDLATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN63</accession>
    <name>A0A2G8SN63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN63"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN63"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000583">
        <property type="entry name" value="MAP3K epsilon protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052441">
        <property type="entry name" value="Armadillo-Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="909" mass="100947" checksum="E4E50678D44187F3" modified="2018-01-31" version="1">MIASVQLNSSLQVPQQSMLLAPQGRKPGSLPKPGMPAPLGHIRETLPMPFILQAPEEQTDNWDDDFEEGISLTKLHALDKTPAEDEKLEADDNARTIRAGRSPGLGTVPLPLAKAPEPQIAPIAEDYSDLVFEEDEAKLEEKVADFKLKNSVRRGLFHPNDIKTLGLQPPSPGPMTAPLPGLAHRRSRPSLSVIATGSSSGPSSARAHSRSSSFVGNESFGREHARRLQKDLDKYADDDDDDYEDVFGKTNGTAAQAMQTLQLNTRLSNKSWFGDEDDEEDDPFAEIDEGYAEEDLEANLQRDKYARLSNQVTQLIDELTPSAPDFQLRDACDQLLNIIHDTPEMQSQLVSAHGMLAILEVLESRTARDVALKLLQIVNALVTTDMGFLESFCLIGGIPVIMGFTSKKYPSECRLEASHFIRLLCHSSVLTLQMFISCRGLKVLVDLLDEDFTEQSELVIHALNGICSVFELQSPTTKNDFCRMFIRDGLLDPLSSALLNVMASRGEIADDMNRKILQIILVFCQVSQSDIHVRNALGTRKIVRRLLRACELLEPQYLVQMLKAVKHLSMNANILEVLQNANAIEILVKILDEQSSGPFGTEMSNHIFQTCYNLCRLNKSRQEEAAQAGILPSLKRVIESSSPLKQFALPILCDLASAGKSCRILLWQHDGLSLYLRLLEDPYFQVSALESILSWLQDETARIEDELMKPESIDALLRCFVQAKANSFENLLDPFLKMFRISTNIAIGIAKSQFFKRLIDKLGSSKAVVRLNLLRILRTVCDVHPNRVVLVERYGIYDIVAKLSKEDVAVLVRELAREIVPTLAPALKPSARLSKGFDTPKSAKAIAPKRMRRHASESLAGMMPASAAMGAHSNGSSHLRTSTRGSVGLNTRSSRQQLHDIPWQGQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPR7</accession>
    <name>A0A2G8SPR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02296</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPR7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPR7"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013842842" description="tripeptidyl-peptidase II" evidence="12">
        <location>
            <begin position="23"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="13">
        <location>
            <begin position="236"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="601"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL35568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="642" mass="68224" checksum="A63753EE5466F089" modified="2018-01-31" version="1">MAFLPSFRLFIGLAAAMAGVASTSTSPLLSRRVLHESRHAVPHGWSLHRRADPNTIIPLNIALRQSNLHYLDDYLLEIADPTSPSYGQHWTPERVAETFRPSTESVDAVHTWLVNDGLDRSRIQLSKDRAYVQLNATVAEAESLLATKYYIYQHDDSGVEHLACHHGYHVPEHVATHIDLVSPTIEFGGIKLGATLAKRGGASPAKGKYMHRPQGPPKIPVAAEALTTDAENCAASVTPNCLRELYGFNYTFVETQKNKVGVVELADQTYVARDLDIFFQKFAPDLVGTEPTLISIDGGTINFTEMDPGLIGESNLDFQLIMPLVGKPQPVSLYQVGGDGSFNLLLDALDGPYCTSDGGDDPSLDSVDPGTTRQCGGAPPSFVYSISYAGAEDLGAHYTERQCTEFGKLALTGMTFLFASGDNGVASNSLGLCLLPNGTAAPVSAGDLTANFLPNFPATCPYVTAVGATQLPSGSKVTDPESASIDFPSGGGFSNLFPRPKWQNRAVGKYLSNVGDTLGYGPEVFNRSGRGVPDVAANGAPTAVVLDGNFTLSGGTSASTPIFAAMVAAVNDARLALGKGPVGWINPVLYSHFFAGVFNDITTGSNTGCGTDGFPTAQGWDPVTGLGTPKFETMQQRFLVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQB3</accession>
    <name>A0A2G8SQB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">X-box-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_01621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQB3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQB3"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14812">
        <property type="entry name" value="bZIP_u3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052470">
        <property type="entry name" value="ER_Stress-Reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46542:SF1">
        <property type="entry name" value="X-BOX BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="42"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="365" mass="39255" checksum="5B968D76F924BF6D" modified="2018-01-31" version="1">MKRPADMDLALSPSPEPQSPSSPASDLAGPPRKRARSDVTPEERREARAHRNRIAAQNSRDRRKAQFAYLERRVQELEEENQQLRAGMGLSQRSRSHEQKDEEREKDRARDQENDELRQRIKTLETGWEAVMKALAASGLPLNVPSAPSSSLSASSSSSPSATTSGHPPTTTFPVFVPPSPVFPISPAPSNHSSGSSTLFDSDDFDTTRHLARLELNIPSPTYPPTIQIGDGASSAVDEVAMDDLFREILAPSPVSPQAPLPADAPSRSRSQSFSEIQLAPAPSAAPVTHPTPTLPEIDWVSEVEMQKLLAMLPVVPQDATPLDAGSLIAPQDDFPSALELELSGWDLAGAVGAPVGSMSSVSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQX1</accession>
    <name>A0A2G8SQX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQX1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQX1"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL36113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="497" mass="54516" checksum="BCD51C2DD8A505BE" modified="2018-01-31" version="1">MLLPPRALHTLNAVANATWSPLRRQCRSFHFQTGVLEDLKARGLVADITRAEQLAGELQKQPQTVYLGVDPTARSLHVGHLVPFLSLLHFQLRGHQIIPLIGGATGLIGDPSGRSTERPLSARETIEHNVTQLTAGITRFFERATEYAEKRLPLSSTRIPPPNVQNNLNWLKDLNLLEFLRTVGFHSRVNTMLARERLVYVSWMNQPHALNGRLSVQARLLSQQGISFTEFTYQLLQAYDFLTLHKTLGCTIQIGGSDQWGNIIAGIELINHANALPGTQDPGAVAEKGFGITTPLLTTASGQKFGKSAGNAVSLNEDDTSVYDFYQFFLRSSDADVGRYLRMFTLLPLEQIEAALEGHNNSREARGAQRLLAEEVTELVHGRDGVARAQLATRILYERDIAAAKADEVLAALRGNPVLHLCDPAEVIDVPLTKLAATHRVTSSNSAARQLVVSKGLYLNNAAVANFQQKLTAADLIDGRLAFIRAGSQKVAVIALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR19</accession>
    <name>A0A2G8SR19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_01878</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR19"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR19"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013909947" description="Amidohydrolase-related domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="5">
        <location>
            <begin position="68"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL36217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="360" mass="39687" checksum="7A7171D86E31E4F7" modified="2018-01-31" version="1">MATLSFFLLFSLFVTHAVHGRVWNDTGVGSIVFEEAWTTAELIHQSDKTVPPVGQTNAELEANLLDIHNQRLADMDATGIDFASIAIRDTTTKTGIADPVNASAMAVSINNELASQISNNTLRFGAFAALAMHDPAVAAQELTRTVTELGFLGALINDYQQSGTGDNQTFLFYDQPQYDVFWQTVVDLDVPVYLHPRVNPPPVSTLLYSHAPFLIGAPQEFAVTLSTHILGLCTNGVFDRFPNLTIISGHLGERIPSDLVRINDQLTRQVVAGMPMQKNVTFYFQNNILETTSGNFAKDLVQFHAQQIGLERILYSIDYPYVPMEQGAAFLADDVPTFLDDDQALALKRGRAIEVLRLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR52</accession>
    <name>A0A2G8SR52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR52"/>
    <dbReference type="OrthoDB" id="3197787at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="326" mass="35360" checksum="F28C7CE4817EB4DA" modified="2018-01-31" version="1">MSSYSSTSLSSYDPPSSSSDYYPTTPSTSPSSSPPSPSPFPLNHRSLSWKTRSKDSLKATHPPLMERQTSQRNRALTLDVRPRIGVDPHALVGKQLTRVRRSRTHPCTTLQFSDGSAYQILVVGYDPHYPGLPKVLESDSPILNPLASNGTANVRLTVSHATSITLSDKAFQVRGSPQPSSPISPSPTSSPSKNAALAPREDRWTQRHAALALKFEEEPGWHCVWATMAEYDGKDGERCVFRNYADVYLDGLRSATAHAAPPKSAPAHVTINPQLPEPSPVHTPSRPTHTPASPSGQQKGGEKGEKNGQKPKRKGGKRKPGAKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR60</accession>
    <name>A0A2G8SR60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR60"/>
    <dbReference type="OrthoDB" id="2802082at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="432" mass="45862" checksum="D3E63244A9AC7051" modified="2018-01-31" version="1">MSSSGSRTHVFAKRDTVLGPPLIAGIVVVAVGFNLVVALSWCVFRQRKKLKEAKSRKAGTSAPVDCEKYETSAAFVSSTKAKPAAPRPKAKGDAHRAPAGGASYYELIRSLQQPAIQPSTRSQSSPIRLSPGPPRGSPDSAKLKQFILRPQDMKNLDGVSFYPKTKHHHTARRSANLGVPPRAGQRRPHSISAETASVYSAASAPLDLHEDLSHPRSTFTLEPIPASAPPWVIDLPKPPTSAVLTDTAAVEFEIPLPSPTTSTSECSQAIVEKPTRNASRPSLSAFSPIALPNGSTPSLVRARANSNPSTPPQIRWLTKGAAKDAANDTAPSPTPSKRPNSISSLSTLFSLHENARAPSVPPVTVAPLNVQRRSNGSRWGSVDMTRGSAPLVSPTLRPSTASAVGQVNAPPALPRRSSKRRAPPPSGKHLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRG9</accession>
    <name>A0A2G8SRG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRG9"/>
    <dbReference type="OrthoDB" id="2755675at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57049" checksum="672782639767C7ED" modified="2018-01-31" version="1">MDVAPAEWDLFLKETAFAVLRDWDGYLERIVYRHTTAPWRSQLTIASGSALIARLKRISIRNVAMGRGWVKPFGHDLVDRPQSITSPEDNALTDRQASPSDEASFSVDLPVELWLTILGHITDKATLAVLTQVSRTFSHEAEARLYHTVTFDLDPAIYRFCESVLADPRRATLVVGFHLMAIENAYGSTLRALLPVLQSLRNLEYLKLNISLGSGLPSLDSHDEQHRRTLTAILGLRFPRLRGFATTGALSTQPQSLRFVLGHPRLEELEFNGSCYDYSAWGPGAGSSTAMFQALSSLRALACRSWFLHDNCAVAGSLTHFHATSLNPAGLVHIARLLGKRLVSLRIAHCVPFSFQHFEPMSLDEVASKFPRLRFLQLDMEYRVKPYINKHPIVFTAPCPRPASENSVTAPDAHVHARPRSRSRFTLALSYARPQTRAVDMTVAAAWHEFLNRTALQVLRGWGDDCVARVVYRHTIIPYVSVALSADGMRLVRRQDTEMREDEWKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRZ0</accession>
    <name>A0A2G8SRZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRZ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRZ0"/>
    <dbReference type="OrthoDB" id="3032860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="48009" checksum="ABD3B0F2DD75DD1B" modified="2018-01-31" version="1">MSNGLTSFVPVLTGPNYLQWALKMQAFLQTTGRWMQPMTKTCPTLVATPSNQDKVDTWNEDNTAARGSIRLHVDDSIGTAIDSKTTAKQVWDYLKDTYGKPGIPVVYQDFRAAMGISIPSDSNPIPAMDKLHAHFQTLETNQFTIAEHIKGMILLSKLPSAMDPIIQVYTSGLTATQTTPAVQLVTFDEVRNRVIMYWEQRQGRHQQKPRDSANKISAVKRKPQDPTFCQHQQRPQGQQQQGHRGRRGGHGRSQQHQGAHQHAHIAHIADTFPVITKGEMDTLPQSRDPHALLHKPVRAETGANNQYPVLRRAFTLAKKLGIEPTTERIRKLRAALDALIAGILRDVQRGLPHHQPEHIAQPNALRGQQPKHCRHTLKERIRPHLRERIGTVVEDEDMEETVSLGLSSEDEQDDNIEEFFDRQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSK3</accession>
    <name>A0A2G8SSK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSK3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSK3"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08681">
        <property type="entry name" value="C2_fungal_Inn1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037791">
        <property type="entry name" value="C2_fungal_Inn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46502:SF2">
        <property type="entry name" value="16 KDA PHLOEM PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46502">
        <property type="entry name" value="C2 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="452"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="743"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="777" mass="83149" checksum="6097008F9C20DC44" modified="2018-01-31" version="1">MSQGQGRHIGTLIVVILKARNLPNKRHIGKQDPYCQVIFNGEKRRTKAIKRGGQHPEWDEEIRFELYEDVDELPQIPGVDPPPPPPKANGKGPPKVKGGSFMAVACYAEDVREPDLIGETKVDLTEVLTKGETDEWFTIMHKDKYCGEVYFELTFWLDEPPPTKKTTPKQTNGQYGGRGTFVPLGESASSSLSDLSRYGSTGSRDEIRRENLPPSLRSSNSRLDIYVAPYESTRSHSSSVDGVVNEFAELNVNHGNRRLSMPVQPTGGSYFQRPASAAPPEPSYDSQVSQVLHGLTYSDGGQGYHYDSSPGQLQPYDSAPLPDPYQPAYEQAATPAPSTFQQVHRPRYSLPPQSSGFMPLPQPSGFVPMNSGPPAPSGFLPPPSATPAPIGYGAVVPTRVASSSFSTLSPALPAPSGFSQGPPPSSSYPPLSQSPSLYYPPPQQNPPPSSTPFPQHQHSLPPSSSFPQHQSPLTSTYSASTPPTSSFPHSNSTPPTSSFPHNLPPTSSYPQLPPPPPASTPPGHQHGYSSSPSTPNHLQPSQSAPPDQPSYGYGHQPSSFDNIPPPPPLSDSPSAGGYGGSRPLPQPQSQPGQSPQSHYSRKQSSLPVPPGPPPQGYYNGTQNGPPALPAATSYQSIPPPPPLPGQVPPPPLQSSFSNGHQLALPGPPPPLPSSMSMPQQLSAQPPPKRRPSLPAPPMSYQQQQSAFQALPPPPPPPSLPSHLQYEPPASSFMPAASNQGYYPPGPPPRPPQYLPGPPQVAQGGYSPVHQPEYSYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSU9</accession>
    <name>A0A2G8SSU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSU9"/>
    <dbReference type="OrthoDB" id="2756380at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11095" checksum="50253EBA94A944F3" modified="2018-01-31" version="1">MQQSGHKPEPAVAQRCSREMVEAIKEVEEEKGLMSYDIILGTELYQTVWRLADANVNGRKNQPSNVAKTVLDCWEGRFPGMLPGRRDNGDGGEDMDVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST21</accession>
    <name>A0A2G8ST21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST21"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST21"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013762239" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="193" mass="19203" checksum="906B1424830D26E2" modified="2018-01-31" version="1">MRAVFALLSFAASALAYSVIEPDATTGWTTSGPNVVVWQMVSTDPANFTIVLNNQNVTPATTQVLAALVGGSLGNVTVNPPSGGWKAGKGFRVNLVKDSQDLNSILAQSPQFDIVASSSSTFSTSVSATAGSATLTVPASATTDATTGSSASALNPTTSDTSTSPTKSNGASPAMAMSNGLVGALALLGAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST34</accession>
    <name>A0A2G8ST34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="6 12">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_00417</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="6 12"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST34"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST34"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000001">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="14">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="15">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL36728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="361" mass="39800" checksum="BAD375BFFA10A38C" modified="2018-01-31" version="1">MASFPLMKNDLILRAARGEETERAPVWVMRQAGRYLPEFLAVRADHDFFEICRTPALAMEVTLQPIRRYSGLLDAAIIFSDILVVPQAMGMEVIMNPGPHFPNPLITPADAEKLPKVVDVDKELGYVYEAITQTRHALKGEVPLIGFCGAPWTLFSYMIEGGGSKTFHKCKSWLFKYPEESKALLNQIADVCIDFLVGQIKAGAQLVQVFDSWAGELAPHHFEEFALPSLQRISSGVRAKLVAAGIPVVPMTLFPKGQNLQIALCADKAGYDVIGIDWCIDPADARRAVGDKVALQGNLDPNLLYGGRDALEREVKRMSESFNGGKKTKAWIANLGHGITPGVDPEDMRWFLECVHSHSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STC5</accession>
    <name>A0A2G8STC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription elongation regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_00718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STC5"/>
    <dbReference type="STRING" id="1077348.A0A2G8STC5"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="5">
        <location>
            <begin position="249"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="449"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL37026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="707" mass="81504" checksum="08DF33BEB857958A" modified="2018-01-31" version="1">MAAVPPPGFVPPPLPPGWTEHRSPTGQPYYHNAQTQESTYVRPLPAFPIIPQAAVSAAAAPPTKKAKKEKPLVKTPVPGTPWLRVITTEGNTFYTHTGEKRSVWAVPEEIKDAVEALEREEALKKAEDTRRAEEERAREVERIQSEVTEMVGKRKAEEPVPVDEYVVTKKVKVDEEEEEEDEDEEDEESEEEDWQREAAAQLAAEAEEEERRREEERKQQEEEARKLKEAEKQKGSSQLNMPERVDLSLDEAKALFKTLLREKNINPLHPWDTSLPLFVSDPRYVLLPSVSARREAFDEYCRDRARELRQSKVKVEKEALNPQQEFERLLKEEVRSTRTSWTEWRRQWKKDRRFYGWGRDDREREKRFKDHLKELGERLRVSFAEKRATARKAEADFFALLRESGLAKPSAVWKEIKNNLTADPRYDAVGSSSLREELFHTYIKAGASEEGLKPQSAGSTAQPAAEEGEEERELRRKERKERAVKEREEKVKAERTKLETEIDRSKLGLTKEEGELEFKTMLVDAIRDPQVSWDSVQPQLRRDPRFVNSPLPMNQQLYFFHAHVNGLRDKHLASLHVLFASHAPGLDTAFTALPVASLLSSLPATKLGYAVDQLEHEYEKWQRERTHEARLAFDQMLNENSFVEFWGRLGKIGGKGVDASIKYDDIGEDTEEDQVDMKALAKSVDLREMIKVLKASCTLHRIRVDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STL3</accession>
    <name>A0A2G8STL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_00786</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STL3"/>
    <dbReference type="STRING" id="1077348.A0A2G8STL3"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="15">
        <location>
            <begin position="4"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="14">
        <location>
            <begin position="436"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="441"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="441"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="571"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL37094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="765" mass="84811" checksum="07F8B45FEEB69E12" modified="2018-01-31" version="1">MVLSSVLGFPRIGANREVKKAVEAYWASKLSADELTKAAADVKKASWTSLKERGVNLIPSGDFTLYDHILDHSAAFNVIPKRYLGKGLSPLDVYFAMGRGRQADGVDVPACEMKKWFDSNYHYVVPELSQETEFKLNFNKALEEYREAKDLGVETRPIVVGPVTFLALGKPAKEASAGFQPISLLSKLIPVYKQLLAALKEAGAESVQIDEPVLVLDQASLYEKQFASAYAELAPVSPKLIVTSYYGRLDSNVAFAAKLPVAGLHIDLDRAPGQLDEVIAAVKPTNLVLSLGVVSGRNIWKTDFQAAIKLGQKAVDVLGQDRVIIASSSSLLHTPVTLAAENKLTPEQKDWFSFALEKASEIAVIAASLSGSQDPKVAEAVKANRVSIAKRREFERNSDATVRSRVAAITPDMFERKSPFSVRKELQQKQLQLPKFPTTTIGSFPQTKEIRQARAKLNKKEITVAEYEKFIEKEIESVVRFQERIGLDLLVHGEPERNDMVQYFGEQFEGFVFTQNAWVQSYGSRYVRPPIIVSDVSRPKPITVRWSSYAQSLTSKPMKGMLTGPVTILNWSFPRADVSRELQCKQLALALRDEVVDLEKAGIKAVQVDEPALREGLPLRKADWQAYLDWALPSFKLATAGVTDALQTHSHFCYSDFDDIFPSIQALDADVISIEASKSDLKLLNTFKHYGYSNQIGPGVYDIHSPRVPSEDEIKERLTAMLATLPSDLVVVNPDCGLKTRGWKETEASLVNLVNAARWARQTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU22</accession>
    <name>A0A2G8SU22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="2">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_00760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU22"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU22"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06155">
        <property type="entry name" value="eu_AANH_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1490.10:FF:000001">
        <property type="entry name" value="Diphthine--ammonia ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="10">
        <location>
            <begin position="2"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL37068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="372" mass="40328" checksum="5DBA9A2C6EDE94D5" modified="2018-01-31" version="1">MIEAGMEAILIKVAGIGLTTKHLGKTLAQMQPTLLKLSSSYGSHVCGEGGEYESLTLDSPMFKYRIKLDEVETVVHSDSDFATVAYLRIKSASLVAKEHLAESDVTIPSILSETFSHLHDVISGTSSPQAEDENTQKQHSVPIAVPIGSKRVGNWIAVTNLQREVDEQAFDISVEDEVRECFEKLRESLVSQALPLASCANINIFISSMDLFARVNAVYGTYFGTSPPARACVAVDLPPPIRVRLDCIAYAESNAQERQALHVQGLSYWAPANIGPYSQAIIVDERVFISGQIGLIPSHLSLPSPQNLAVEAALSFQHVHRVVDALKNNSGGGWSGHTQGIIYWLARKSDVPAVRAASVAYAEVSSLFSRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU79</accession>
    <name>A0A2G8SU79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU79"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU79"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="203" mass="23000" checksum="F2957B331D82FA29" modified="2018-01-31" version="1">MKVIYGMDGKLRQPREEVDPACALPTLKELLQALREAETSCLKRTPPFSVETPRSVLDMDDKMLDQYLAFCEKALLPREDRMSPRNAATDQFPLGPDKDTSGNSIEDSEEDRVDKSDLSANLIAEGVDQLQPGEEYAIYNTQDILGSLPTDLELVISRAAKWAGVEDNYVCGTVERFERRVLRWWERQQRKERAGRSMASASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLN8</accession>
    <name>A0A2G8RLN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_15111</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLN8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLN8"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL22423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="814" mass="93412" checksum="6720D6562F3AE18C" modified="2018-01-31" version="1">MSHIANISPLHISRDDAVNPGGQSRRSSPDSREQSRSPPASMVDANGGFFDYTEEKHLHHIEAKLLAHRRGSDANTASRPTSLLSSPSSATAAPQHEAAFLNTPKLSAIPEPAAITPPAWDGRLPDAMRPTSPIDLKSPARPHDLVMPAENIPILEALEECLSLRDKYMSVSGQKLGFNPRDHDGKFGGLDDDIVGVCGVHPDVDFASRAPPKSPFRKWRIYPRPPPPHWHWKGKGTVVPINAGYEATEDEEFDFSKCEIPGADKSDFAIDEKGVFQVYSSTEEKGKKPRFYVPSIKEYFLDLEKILSVICDGPTKSFAFRRLNYLASKFTMYSLLHEQKELAEMKAVPHRDFYNLRKVDTHVHHSSSMNQKHLLRFIKSKMKRSPNDVVIFRDGKELTLDEVFKSLGLSAYELSIDTLDMHAHNDSFHRFDKFNLKYNPIGESRLREIFLKTDNYIQGRYLAELTQEVMTDLEQSKYQNCEWRISIYGRKLDEWDQLAKWIVKNKLYSHNVRWLIQIPRLYDVYKQNGSINTFEDIVRNVFQPLFEVTRDPSSHPELHVFLQRVIGFDTVDDESKAERRFHKKFPYPRVWDAKESPPYSYWVYYMYANIVSLNQWRHARGFCTFVFRPHCGEAGDPEHLASAFLTAHSISHGILLRKVPALQYLFYLKQIGLAMSPLSNNALFLTYERNPLPDFFKVGLNVSLSTDDPLQFHFTKEPLLEEYSVAAHIYKLPQSSLAELARNSVIQSGFEMEVKRHWLGLNWYLPGAAGNDINRTNVPNSRLEYRRQTLFEELRMIRTKRPVDSQASITAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLV0</accession>
    <name>A0A2G8RLV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_15168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLV0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLV0"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="216" mass="24379" checksum="80911BA58358D661" modified="2018-01-31" version="1">MPVGVEAWVTQIPPITRAWLALSVLTSLAVQTQMVTPLQLYFSFKAAFTNVQPWRAFTTFFYFGTISLDFVFHMFFFMRYSRMLEESSFANRKADYFWLLLLSSLMLLGLSPLVNLPFLSSPLAFVPIYLWSRRHPSTPVSLFGLITITAPYLPLALVGLSWILNGTWRAAAGDLLGCAVGHVGWFVRDVWMREMTGGPTILSGPPEALRRLFGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM87</accession>
    <name>A0A2G8RM87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_15314</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM87"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM87"/>
    <dbReference type="OrthoDB" id="2317741at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013715114" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="133" mass="14308" checksum="6600FA3EAB9E46C1" modified="2018-01-31" version="1">MFKSVMQLSLFSFLLSLLAFAYALPVAIRDVFVPPVTSPTTGTVWTVGSQQNVTWDTSNAPAQITNKKGQVVLAKDGRLDIENPLASDFDILQGWVTVTVPDVTPDIDYTIVLFGDSGNDSGVFAIMPSVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMT1</accession>
    <name>A0A2G8RMT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMT1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMT1"/>
    <dbReference type="OrthoDB" id="3269067at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="34"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="433" mass="46808" checksum="92FE88D87E52BBBD" modified="2018-01-31" version="1">MPSSSSSSSLSVSDALTNLSKAATIALNAVQGAHNQVYEEAERARAERDDALRALHDAQLDAKDLEGREERWKAALDKSDLTIKHQTETIAQLRSEVQTWKTQLTRLEESSRQEIDGWKEQYLRAEHERARLSARIEELIAGQLAWNAAAHAYTAPYTPRIGYTEIPEPSTSSSGLTTKRASTSHSRRAPGTPRANGHVPAPDDDDDVPLTSARKPKTNANRNASERRSRAAASPSRAPTARRKEAPAEVPQASGSRATPRTHAGAQPNMPPRTQLIRRVTAVVDVKEEDDDDGEGLDDLDSAASGSVFDPDEHPPVAARSRRRRGSTASGRSKRTRREFDDEDEEDQSADEVDGAHGDDGGDAEDDELLLGPKTQQTRKPPRTPSQGQPATKVPRTGGSARQTASTKKRKLVDGDAGAAGGRPGSAKAVKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMU1</accession>
    <name>A0A2G8RMU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMU1"/>
    <dbReference type="OrthoDB" id="3183258at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="339" mass="37537" checksum="BDEB696BD72DD339" modified="2018-01-31" version="1">MASPATLTYGPIFVGVIFNVLLYGIMITQTYLYFNVYKKDRLWMKLFVGLLFLCDTLNTVFDIVFLYIPLVNNFGDVTALTYASWVFATDPVMTALIGSLVQCFFAWRVKVLTNSLPAVFFIATCAIVQFCGGLGTSIAVGMIPEFIHFQKFEVIVIIWLAFSAVADCSITVALVWHLRKHKTGFVATDDIVNRIIRLTVQTGLITAVCALVDLILFLVTPAGLHLLFNLPLSKLYTNSLMSSLNSRSGWRYGSGNGESTSDDVNRTDHGRHMNVRSETGRRVSMMPPNQVYIDVESHEMVDVLDAKMLPTGAAIASMPTKQFNEKAGKLTPHSGSDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNB2</accession>
    <name>A0A2G8RNB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNB2"/>
    <dbReference type="OrthoDB" id="2765130at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="405" mass="45073" checksum="A0CF4BA6611FAA9E" modified="2018-01-31" version="1">MRCPKQTPAEEAQHAQFLQQLGGPGMLWPPCPPAPQPAFNPWIASQYPMTGSMPPLQSQLPPLVPGLGERWFQGLVAAVSKEIKDNEKKAAADNARKKNAAPADLSVEDEKALIAALRRQREGTLTMEQVFGELSKKYGHTETEWKTLFFANYERLLSKLDLHSNLGPASEGSPQRFTSPVASRTRSMSRNQPSRSSTRTASRTLTDSLEESESEFESETETESEWGELCSDGRSALRELESSSSSPRAKRKPPRGARQYCRVTDADLRAMAQYRFENGDGDEVRRYGYCAWREFALRPENSKRTLPAWRCIPRRLRHAAAIDRYVREFQLRVEVTGSKPILPILPDPQDSPGTSRSGPGMAVEAAQKEASMNQQNGNSGSENATMASRATDAMEIIDLTDDKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP37</accession>
    <name>A0A2G8RP37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="3">SDH assembly factor 2</shortName>
            <shortName evidence="3">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDHAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP37"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP37"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="172" mass="19253" checksum="8ACA5D1A68DD513C" modified="2018-01-31" version="1">MSAAMLRLAARRCLRPIATSTALPSSATRTTATRTISTTARRAADPWLLPNMPGHLEKTTSPPDAPAPEPLPRPGESVEKMRARLVYQSRKRGTLESDLLLSTFARERLGDMSEGELREFDKLMDEPDWDIYYWATGKKAPPARWEGSRVLAQLAQHVKNEGKVVRRMPDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPK0</accession>
    <name>A0A2G8RPK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPK0"/>
    <dbReference type="OrthoDB" id="2737129at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="242" mass="27782" checksum="60BE5F9A74FF05A5" modified="2018-01-31" version="1">MSSTAETSAASTVPESGPVNSLAPILDEQTSSTSDSNHTPELQATPEKQARIRKHPMREFKWGVSRKQFFVHFLDLTSDATMKGNLIRNALPTTTLPCWLDPMWVDIDSPTRLPLCWYGVPFVSRLFYGCAERVGLASYYTRKILASNPGDLDPYRTWGNMQEWFKKKTGLKLDLNLAWGEDGKPDVILTLWSNHDIDNITPKMWDGTFEMLDYLEYGEEYDLLWYLNHNLEQVLSDDCKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPP6</accession>
    <name>A0A2G8RPP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPP6"/>
    <dbReference type="OrthoDB" id="2765210at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="179" mass="20180" checksum="B2BDFFCE79002528" modified="2018-01-31" version="1">MKHWPIHAQSCDRDVTRDARTVEGVQPVYPYVGEITLSTRSAVDPLPPVSIDHMPAPAASGSTYDYVIYSFYAKHNGDGSRILPVNVSPTPMSKSGDALLLSHCFQSTSVSRSFIICYEGRYNPNRELVRLTQSVDMILQRPWYGSVVVTKFRSRACTSYVDITFDDVVHIRDYFAYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ95</accession>
    <name>A0A2G8RQ95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1690 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ95"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20476" checksum="8259DD534DB79875" modified="2018-01-31" version="1">MGASQSSPQPDEKVFTTDTSLHFSDDVVHQLVDHQASSDIPHERQLTIDAHIRARIQSELSRLHQEEERVREEIEHALEKENLDRERRMAGEDSASEEAGPSGSVKSSAALMGDLEELRQKVEKYHARQNSQELSAVRTKGEEVVSCYQSNPTTPLDCWKAVEEFKASVGQVEQRYVSSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQQ2</accession>
    <name>A0A2G8RQQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_13572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQQ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQQ2"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="52"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="242"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL23821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="522" mass="58084" checksum="39BC4C0AFF98B7FD" modified="2018-01-31" version="1">MPIREFVYTILTISYAPPQKLPAFPPLATIENIILKEKQGNCVPVYVELPGDLLTPCVAYLRIAKDSKYSFLLESVVAGENLARYSFVGADPFKIIRVGPNEETTGDPMVALQKELGVYKYVKLPEVPTFTGGAIGYVGYDSIMHFEPKTAREVEDPLGIPEAIFMLVDTLLIYDHLYQSVKVVSHVFCPGDAGQVNLSFIYQTAVSKARRLAKLVMSTVTPEVYQRPIVLGNEAVSNVGKAGYEGFVTNLKEHIVAGDIIQAVPSQRLARPTTLHPFNAYRHLRRINPSPYMFYLDCGHIQIVGASPETLCKVENNKVYNHAIAGTIKRGQTVEEDERLGAELLASEKDRAEHIMLVDLARNDVNRVCKAETVHVDHLLKLEKFSHVIHLTSQVSGLLREGKDRFDAFRSIFPAGTVSGAPKIKAIELVYELEKQRRGIYAGAVGRFDFAEDEMDTCIAIRTMTFKDGIAYLQAGGGIVFDSVEEDEYVETLNKLKGNMRALDVAEQYWYDIQNAKSVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQT1</accession>
    <name>A0A2G8RQT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQT1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQT1"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="353" mass="36989" checksum="C2D2347E1CA80540" modified="2018-01-31" version="1">MPSSAPVFSTPLTKLFGINHPVMLAGMNVAAGPRLAAAVTNAGGIGVIGGVRQSPKMLQDNIDELKSHLEYKNAPFGVDLLIPQVGGNARKTNYDYSKGQLPALTDVIVKSGAKLFVCAVGVPPKEMVEKLHSAGIVVMNMIGHPKHVAKALAQGVDIICAQGGEGGGHTGETPFSILIPAVVDLCKKAMSPLTGEPVLVVAAGGIADGRGLAAALSYGAAGVWVGTRFVASAEAGAPKVHKELVLSAGYDDITRTLIYSGRPMHVRKTPYVASWDNKQQEIAELTYQGKIPHEVELEKHPEKSMEGRMWLMGKVAGSINDIKPAREIVDELVTTAAKSLQGASALVVSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRI2</accession>
    <name>A0A2G8RRI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13878</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRI2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRI2"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054728">
        <property type="entry name" value="RsmB-like_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22458">
        <property type="entry name" value="RsmF-B_ferredox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="214"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="507"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="306"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL24126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="577" mass="63581" checksum="8266CE93F5221DDD" modified="2018-01-31" version="1">MDGVEDDDDLLRGPTQELELGSDDDEEEEEEELPVKLKSKKSKQADRPLKIIPTASDASSEESDDDNEDGRVTMKNIEARSRALDAKAAREAELDIEEMQQAALAGEESGDDFADADMDEEGEGGEGSEEFVLPTAEQREEEKTRGGPDVHTVQRRMRECVRVLGNFKRLAAKGRPRAEYIQQLISDIASYYGYNDFLAEKLFQLFPVAEAIEFFEANEVPRPVTIRTNTLRARRRDLAQALINRGVNLEPIGKWTNVGLQVFESSVPIGATPEYLAGHYMLQAASSFLPVIALGPQPGERVLDMASAPGGKTTHMAALMQNTGVVFANDANKARVKSLTANVHRLGCKNVVVCSYDGREFPKVIGGFDRVLLDAPCSGTGVISKDASVKTNKSERDFTLLSHLQKQLILCAIDSVTPDSKTGGYLVYSTCSVTVDENEAVVDYALRKRPNVKLVETGLEFGRPGYTSYRGKTFSDKLNLTRRFYPHVHNMDGFYVAKFKVEKRAKVKSDKEETAAGAGGADADVEMNEPTFPFNEDEDRPYIEENERRRMKAKSRKAPPQTKPVPVAAGGDPAAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSU2</accession>
    <name>A0A2G8RSU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSU2"/>
    <dbReference type="OrthoDB" id="2757612at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="346" mass="38483" checksum="DCD91250685C5E7F" modified="2018-01-31" version="1">MTTTLSGLDTWSVISGAVGVLTVLPFIWAYARSQHPETKLAELDSTLNDTEALLRSVVEEGLLDPDLHVPHFESRLQHFRAIADKLRDDTFIASVEWRRLLRAWYDGLTKHISTVCKQVKGVRANICETSASARMQLTHEHAEDSVPLPFRRRWRGGVAKLWRCIISLARRNRHAYVDDARDSATPASSTFDTVVPSAEDAGSGTFVWDDASTPEADARSCLPPSRDTSPHWPRSPRACPHVPCTASTIHELRVISRAIRRVGRELASQGVTNARLAQLVQATHKRWSPASGKAHRLPRRSRKQLGVTPRPKHALALQGASDPAIDIDPDCDCDCDGDWEETMCEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTB4</accession>
    <name>A0A2G8RTB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTB4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="148" mass="17072" checksum="764143075259ACC7" modified="2018-01-31" version="1">MENNPATHWQWLIYFWMATEDALDHVQITSGRLWCTKVAATLPLSPTPLRPGGKKLYSACDHVESTSHARGLMWIQKCRDEVVADVRRRLVVQEMPTVEELVRRSVVQTLKEKPWCAACSDIAWDIVRLGTTFRERMVWALDKVPLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTT3</accession>
    <name>A0A2G8RTT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12808</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTT3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTT3"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="12"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="360" mass="40590" checksum="48080C78D4F7A09C" modified="2018-01-31" version="1">MAETGGDFLLMHHDDIIRMIYKLAIEAGATVRLNTEVTSIHQGSDEIPNPSVTLANGDVLTADILIGADGYKSQVRDIVLEEEDNARPAGMTLYTGVVNAEDMLKDPELRPYAQSDEWPIWMGPHRSVCGHPVRAKKEYFFHVYSWHNLDGLEQSGEESWDELFPTEKINVETHGPKVQRLISMAPHLIRTRFMSRKAGIDEWVDRTHRIVLLGDAAHPSFPGGSHGASMAVEDAVVLGSLFSHLRMIDQIPSFLDAYQELRQRRCDLVKLADIGNAQMVSMPDGAQADARDEDMRRRKDEWDEGTLKAQFEEIAEIFLYDAGDAAEEWWVNWGRFSQTAREQPNVVDFNGFSSVVVHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUE8</accession>
    <name>A0A2G8RUE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUE8"/>
    <dbReference type="OrthoDB" id="2725436at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="20187" checksum="74BBA9FA9259415A" modified="2018-01-31" version="1">MHLNDIQSKSQPASSHPSEERCTVDMAFSDLLLPEYLRLGAHNWFEFKLAIETILRLRGISLTHLRCPKCPPPLPVTHSGTETNRASEKSRAQLEWAAEEDLCKTIIVLNVRGDHMRLVEYNYASCSTAELWALLVQRDEDIRKEWERKVGWLDCIRTLAPWVFLVIVCAAWLMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUL9</accession>
    <name>A0A2G8RUL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_13096</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUL9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUL9"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="504"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="59"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="305"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL25207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="779" mass="84923" checksum="1650902896824BBE" modified="2018-01-31" version="1">MSSSSQSAVNQRSFHSHSPSNSRHSRITVEYHRPSRESIQEYNNLLAEAHLHASAANNYSDNFVPSRTAPPPPGPPRTAATPPKVRNSLQRPPHRRPSHSVDRDPFRNDQPMTTTSPPPRPSRANTATLNDIYPTQAALARHRLSDPVISPQDVPYYIDPADQQQYPGQQQSQLAQGGYAANYDMPPLPPAAYTPSTPSTISAAGGRSRSGTAAKSKKGMFGFITDIVNPSKRPEISTPYDPVHLTHVGFNTSTGEFTGLPKEWQQLLQESGISKSEQEKNPQAVMEIVKFYQENNRGDASVWDKMGSIAAPTPPTPVAPAPPKPFDDGFANPRAAPMPPKKQAGPSQPQPVSHRMAPPPPAPATPALDRSTSQRLPQTKPPKPAEQLARANTTRDRRSPAPGQQSAHAAVHHPGAPAAPTKPPKVSPGSSQTDLPLKGSPSMRDRSQPAPSAAAASLQKTAAAAGASATPRRREKKEKDIAKEADIVKRLQQICTDADPTKLYRNLVKIGAGASGGVYTAYQVGTNLSVAIKQMDLDKQPKKDLIINEILVMRASRHPNIVNYIDSFLHKNELWVVMEYMEGGSLTDVVTANLMTDGQIAAVSRETCQGLVHLHRHGVIHRDIKSDNVLLSMNGDVKLTDFGFCAQISEANAKRTTMVGTPYWMAPEVVTRKEYGPKVDVWSLGIMAIEMIEGEPPYLNQNPLKALYLIATNGTPQIANPEQLTPEFREYLARTLEVDAEKRPTAAELLEHPFFKLSEPLRTLTPLIKAARDIAKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUW1</accession>
    <name>A0A2G8RUW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CobW/HypB/UreG nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUW1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUW1"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="69"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="275" mass="29232" checksum="9FC0E8D4B8BAB28F" modified="2018-01-31" version="1">MADTVQFINNLSGAGDVGLAHTHSHEGHIHSHGPNEHGHTHEILDHPGRFSERDMPDYAGRNFEERGFTIGIGGPVGSGKTALTLALCQKLRAAYNIATVTNDIFTKEDQEFLITNKALPASRILAIETGGCPHAAIREDISANMGALETLQAKYECQMLFVESGGDNLAANYSRELADYIIYVIDVSGGDKIPRKGGPGISQSDLLVVNKIDLAPYVGASLAVMDRDAKLMRGDGPTVFTSVREGKGVDDVVDLILAAWRTAGSPGKAGPVGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVH3</accession>
    <name>A0A2G8RVH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_12423</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000052">
        <property type="protein sequence ID" value="PIL25512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVH3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVH3"/>
    <dbReference type="OrthoDB" id="2013610at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="14">
        <location>
            <begin position="406"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL25512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="742" mass="85986" checksum="0E7028D28A293F92" modified="2018-01-31" version="1">MNDIFKDLIILGKVTIYLDDILIFTNDIEEHRTLVREVLKRLAERNLFCKPEKCEFEQPKVEYLDVLVSENRVEMDPVKVKGIAAWPVPQNASDVRKFRGFANFYRRFIKDFSAVCKPLDRLTGNAPWKWEAEEQEAFDELKRRFTESPVLSMYDPDCKTRIEVDASGYATGAVLSQEGEDECNYEIYDKEMLAIIRALQAWCHYLEGLPSVFEIQLDHKNLEYWKTAQNLTRRQARWALYLSRFEFVILHKPGTSNGRADALLRRPDHQTDDADDNLDRVLLQPHRFRVLAAKKGHMSVVPEKALLRRIRKCGERKQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGRVYVSKDDALRAEIVCIHHDLPPAGHPRQAKTVELVTRNYWWPGMVKFIKDYVETRDICRVVTCDFITGLPDVDGYNALQLIADWHGKIIHLIPCTEEIDAEGTADNFIREWFRLHGLPCKIISDRGPQFSSKLFRAVLKGLSIESAMSTAYHPQTDGQSERWNQEIEAYLRMYCLRRRNDWVKWLPIAEFAFNSHVHSSTGYSPFYLMYGFEPQFHIPMLSMAVPSADERREELHQAREDATSALTLAAERMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESQRLTVEPCSALAAQVLVDTLARLRKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVR2</accession>
    <name>A0A2G8RVR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVR2"/>
    <dbReference type="OrthoDB" id="2757163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="347" mass="37657" checksum="0C7EB90B7D73F8F5" modified="2018-01-31" version="1">MAVTVSTSFAVLYGLFVALAVVSLYLLFRRGIRRPLSAIQVFAVTVLLMSTTIHWAVVVLHRFGSLLVNPGMDNETFYGQFAVEECVGTATLTINIVLSDLVVWWRVWVLWPESRVVRISGCVLLFATFVLSVVDTTFSCQAQEGFLFEGLAVGTAASALSLATNFTATVLTAYQAWLYRKSARDYAESGSINTRVEHILALLVESGALYCALWVVILVWQVGDDEGSIRAVIYAQHQHLSLSFWTEGGVLIEGCLVPLIAIYPTVIIVLVALNKSGIKNGFKRDIGGARPGGIAVAVETVVSTHSDLDAEDSPSEGTAGLGSFSHFGDPRRQGLDVSEKMAWQMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW79</accession>
    <name>A0A2G8RW79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW79"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW79"/>
    <dbReference type="OrthoDB" id="4849794at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013607403" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="817"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="999" mass="109281" checksum="9516A376A475D75F" modified="2018-01-31" version="1">MAPLSRAALALGGLLALASSVAAIGADNCVGFANASDLYVVVKAGKATPILISADEWPGVQRAASDFVGDIQTVSGVKPTFKNVTATAKSDYPTAIIVGTLGKSSVIDAVVNRTNLDVSFVQGKWEAYMTTVVQNPLPGMDSAYVIIGSDKRGTIFGLYTHSEQFGAVSPWYWWADVQPTHHNSLYVKTAGCHHDTPSVKYRGIFLNDEQPALQSWAKVKFTNGTGAAHTGSPFNHFFYTKLFELLLRLRANYLWPAMWSSAFCVDDDQNQSLADWYGIVMGTSHEEPLMRSLPPEWSIYGKGAWDYSTNQANVYDFWKTGAQRARNYEGVFTMGMRGAGDAPISGSNPIQLLGKIIADQRSLLKDVFNTSDLTTIPQVWTLYKEVEGYYEQGLTVPDDIVMLWSDDNYGNIRRYPTIAERKRSGGSGVYYHIDYVGAPRCYKWIMSSQIERTYEQLSTAVTRDATKIWVLNVGDLKPLEMHTEFFFTYAYDTTKWNPQNLNSFVENWATREFGFSSSDAATVASIISTVTQHNARRKPELWNTTTYSVLNYREADTVLASLQAAGDASTKLYNSLSSASQPAFFELVQHPVQASLALQHMYIAAAINNLRAIQYSVAANMYKTQVESLFATDFDLENEYHTILDGKWVHMMAQTHSGYEYWDQSQSNVMPAVQAVQAKKQNLAGPMRITIEGSMGAWPGDDRYSCASGMSCGSPVTTLDNYNPFGNRYFDVSSGGPAPFTWAATSNVSWVKFSLSSGSISSSTLEQRVFYSVDWSQVSGQQTASIAVKATPQGLGTQTTHVILQATQKSVSSGFHGYVESDGVVSIEAAHAARNTSVQGLTWINIPGLGKTNSGVTPWPRGGDDLNFTAGAGPSIEYDFYLFDTNKGNVTITVKVSPSLNNLGDDRPLGLALQIDNGSAQTQHFVPKSNPGSLPSGWSGNDGWAANNIIDVKYTFTVGTGAHTLKVWMIEPTVVVQKIIIDAGGLKSSYLGPPESVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWE5</accession>
    <name>A0A2G8RWE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWE5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWE5"/>
    <dbReference type="OrthoDB" id="2750871at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="53"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="898" mass="101063" checksum="DCC2E793A3BBE317" modified="2018-01-31" version="1">MKEFQIVGGLLDGILAVVHPDLYQSAIALMAQLYADHTASRAVIAEWPSCYSAVQIIANRIHELPFTFCICPNADREDLQLLDLGYYPASKSRPKTVFTTRVLDDFLLANKECKTPARNYYNKLRRMSNSAFPHMVPDRYKELLRVSRQWRNQQMRLSAGFGHRAQTVGPGDLAILCPACPQPGQNLPEDWQDDPDSWKFTRSVVLDGNFSAQHKHMRNPEDDVALADGHAFMVTDGPYKEHLRTAREFKEKSTCHEHRAVLTATMERAKFEATGIGAAACSRHGFFAPHACVDFQQGERQRNMDYVLNWILAWLNGLTCILVLYDIMCQYFTHLRARFEQSPFLTMPVGLTIQRGIGQFHVHGHVAQCFARFSTNFISGAGMQDGEIIETLWNQTNAIADSTKGMSSAHRREVIDDHMNDSNWKKLTKITNILIGKWKRATREHGPAVEAFEDLCKATDADLREEWQAAADEADAARDGDPTAMDIYDVSAQPLPSRKEIQLMLAEQELAHEAPVDGVADWIAQGLRLEETKLAVAYSARRLKAVGATQTRLSLVQQRQKLRKDIGVFNKESATHLGLQGSPEFLPESVDLGSLGAEWDSFAATDNPATGDVETGVDEGPDFSQPERLALILPSTLGPDFLRRHDLLHLACTERLLREGQMNDALQAIRTGIGYKSLLYRTKVRHAPTYRAKLRSFDDTHIADEGVRKHVRIYTQARAAMEKLFDPADGGDTELRTRFRENYKEIKKDDLRATTAVLESFTPGLRNIHAAWFWNIADTSIGADSQWMKESRLDHAGFLASARALLKEPIRGGDEWGFPKWWTWNVAPSEGGKEMPGWWNAPTADVGPPMPLFESDRADIEAVSGRAYKILGELLFQKECKLQGIEGRITEFQLRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXA4</accession>
    <name>A0A2G8RXA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXA4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="301" mass="34593" checksum="CAE83EEBB4580A5D" modified="2018-01-31" version="1">MEEEPDHTGNSLLRSSSSAGSDDDDLPAPLRFYALNNTMWLARAPLPWRLMILQRDGTMTLIPDSEFADELCPRVLEMFVMDRHHQEREMAGLAPYGALIMETLGGDLSEVELEHEMLLLKNVLCHWDNVAATWILAHTPNRYHDIYLLNVNPEPWRTIQQDHSIYSLVQYTLGYNIIDMHQLAEDLNNHPNAPTNNSGLLCAQLFCGWWIIRDCDGNYHQLPEDSYDFRALILPLHPEQDNDRLETLWRLHVGYLGVWPPQGCDIQDFQAYCARFYELEGEAMDTGRDDPQERGGANVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY10</accession>
    <name>A0A2G8RY10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY10"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="22823" checksum="7457D2FD75E84249" modified="2018-01-31" version="1">MSTAFLLRLHTGVKFRGKQPAPKGPRAPLSAGSYAARIRTLFWIALSNFVFPVVFDIAQLVLIFRDASYIGGGYVISVNSYISILGVLFSTIWSGSHRVAEATLTSSSPQPSVCSQCRGITGNPYHSAASLIARCLPRPPTPLPLRADLGRSGSGSDSPQLKGRFAPTSSRMDADALSAEGSPTHSHELFSQTEPASRFSVAIPAAIGVRTQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY76</accession>
    <name>A0A2G8RY76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY76"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY76"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="45"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="352" mass="39874" checksum="FC6B8D767FDFDBF4" modified="2018-01-31" version="1">MSADNHEARPPKRSRTEDTPRQSSAATPLDLDNFQCHEEFWFDDGSIVLIAQQKTGFRVYRALLTAQSTIFADMFTSSSPSAEEMIEGCPVVHLSDTPEDIAHLLRVLLPKSQRLLYSRKSILSFHQLSAIIRLSHKYHVQDVLDQAVEYLQTHFTSTFDAWTSNTALRVPLFSARHAIGVVNLARLIDRPALLPIAFYRCAQLGGDVVSGYRREDKTVEYLRRRDLRRCIDGRNELAEQAASVLAEVFGNAYPCDACVRRERCAIALLNLSARMVADEFVSEVDVLTSWAGRIEEWAEDLDLCEPCRRAVITQDRRARRQVWDDLPTIFGLTVEGWAASEDEDETTDPDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYG8</accession>
    <name>A0A2G8RYG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYG8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYG8"/>
    <dbReference type="OrthoDB" id="2747532at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="368" mass="39380" checksum="8E1E6262B3829D4D" modified="2018-01-31" version="1">MPVALSLDAYGGFAGHASLGFYAATLSVEIGLYAAFLVSYTYGTWCILSCDQQKAPRRGLNIGLLVCNTLMFLLATAHLALDARGAMHGFTEGSPLFDAIKFVIYVLETLIGSCFMIYRLYRVYSRRWQVIIVPSVLLFADGVVGVSSTFLGVAGFYMSAVFYSLGLLIDIVCAICILARVLRISRDSEVHHVHTRRSTQNQVWRVVEALVQSTAITCAASMSLVVTFVNSASLGYPTCLNVFPALIALVFSLTVLRIALNARAADRRPSPSADSSASHTGGVASDQRAMMLGSGTMSTAASCGTLAESLRREFAATPSPTRIHISTTTVVQCDLELLPNPKPPGLDLDSEVQGGRGFVLPVAVPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYJ9</accession>
    <name>A0A2G8RYJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYJ9"/>
    <dbReference type="OrthoDB" id="2756277at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="327" mass="36092" checksum="5923EF2D8C0C923D" modified="2018-01-31" version="1">MENFTSSETIQPIGHELYTEHDIVLWHTVSLLLQSVLFGAFAVTYATARSALLKGSGPFLHVEQRNIVYLRAITAMLGFAFANLAMSFMATLLPAAGYEGKLDIPYKTFRDKYFLFLSVNGIQFYLYVTQTAIAGGLLTYILCIKSDGNPKAYSHAALCSVLGTLFGYFAFRDGLWAFQFLFFTTVGVNLLSSGPMMQASLRGTEIVRKPWDWHPRALVAFFCSKEFTDATVQSAAPYSLASLLLPVTFLVDTNILFYTAMSVLSPLMGIVFSFAVVGWSRAGGANEPYVPWTRQSQGRPPMSDTGYISLTAPLDRSPDLALYGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYP5</accession>
    <name>A0A2G8RYP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYP5"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="606" mass="67292" checksum="B81875C5A434170E" modified="2018-01-31" version="1">MQKHPQLLSESFSYSPHLYHAYYFPLELSPFTLECMNSHLGRLKSLSSPGSPTFSDASTTASALLGIPSSVTTVSDYSPSEWEKETYYHGVSLNHPELLYRSDYLHTPFLRPTGRFKRNRTKSVVGVYNTPLNPVWHTVAPKIREVLKAHKIRYSAIHAVRFVTHGREGEDEQDSLGPVVVWIATHPASRTHPTGTTADDAHRASPDILALLEANGVHGAVVEWFEGALERLFGPPLLRVSPRANPTYDEDVQGSVAFFFHENKDKDGNDSTRVLAVSNCHVLRKDPTVPYQYQRGRGARQRVRVAGFRRFQRGVDEIVTAIAHRGVTADLRAREIAEQEPQLESEDAEEAGHAGRIVDSKRERLAEALNDIAALEAFHEQVCRQWCDINRRNIGHVDWAPEISTDVDGHGYTRDIGTFEVDAERFRAEFEGNVVDLGKNPPGKKYAPNKLIDKFYPDREGYTTAFEFPPFGQLRISGCLTREDLAAPDTCDSAGAPCIVVMKDGNASDLTVGRCAGLEAYTCDASGTVEAVEIAVFNYAPLSGSFSERGDSGALVFDGRGRMVGIVHSGLASGGNNHVTYATPAWWVIEQLKREYPHADFDRDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYU7</accession>
    <name>A0A2G8RYU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYU7"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="133" mass="14614" checksum="31CDBF9FD8718678" modified="2018-01-31" version="1">MRETIKAEVMPLLQWTGPKAMALLWKAIKKLGGVAMKRALQHAVGTSRQMGLLSRSFQDYIEDEDPNELLEDNAQEIAGREGGSNREKPALYMALRDPATGQPLTIHAAILDLLQARFVGMAVTVLPRSTPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYX5</accession>
    <name>A0A2G8RYX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_11232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000040">
        <property type="protein sequence ID" value="PIL26705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYX5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYX5"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL26705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="551" mass="61796" checksum="3C732F3E9066943C" modified="2018-01-31" version="1">MHQLFRRYETFSVLTHAALLLGPPALIAASAVPGPSTNLESFKSTFRYSALLYLATLAISIVVYRISPFHPLARYPGPWLAKVSMLVPALYSTTGRRNRAVKRMHELHGDVLRIGPNELSIRDPAVAMRILGASGLPKGTDWVGGMLRDHNLPVVGIRDIDEHLRRRRAWNRGLGPAALREYEHVLARRAQLLVRRLEEQEGEVNLGQWVNYFAYDFMSDMAFGGGSELLSEGDKNNVWAVLDKGMALATFFGHVPWLGVYVGYIPGAAWPLNSLHRHGEKCAAKRLARGSTTSDLFHYLNNEDLPDRTPPPARQLYDDGVLAVVAGSDTASSATTSIFNCLLTHPETYARLQEEVDRFYPAGEDPFNTKHHRDMHYLQAVINEALRLYPPIASASQRHLSRSAQGITIGSIYIPPGTAIRLPPWSIHRDARNFTFPESFWPERWLIASGHLALADAPLPSSLSQSSADKSKSSIVFVHNEQAFLPFSVGPMNCPGKALAMQEMRMVVGALVQRFRMRLRDGWDAAFYEREIRDYFNATRPRVPVVLEKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ99</accession>
    <name>A0A2G8RZ99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ99"/>
    <dbReference type="OrthoDB" id="1715602at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="140" mass="15855" checksum="460D1A119610F6B3" modified="2018-01-31" version="1">MTMQTLKITTTTSQTRRRMRITTREKQGTKHTEDEEDEGEGGNSLDSAFSANKLDDDIFDVLRNQGPPGLDELGDELEHYLCLSIESAHAILCLSMWSRAGFVKTEDQRKVAQLDEMDRDASDLEMDKGWDKIDLGKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZU4</accession>
    <name>A0A2G8RZU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZU4"/>
    <dbReference type="OrthoDB" id="2753572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="25008" checksum="61052EE915644D74" modified="2018-01-31" version="1">MAPYVVYSGQDEKPVLPLGDLINRVLDPEEPSSSNSESSSSVQSAPNPAEASESLKLPLRNFVWGSKLVRDALPHPMIPPWLDPLDVDIDDPRKLPLCWYGVPFYSDMVFAYAQRIRIAVYMKHENLNLKPGDLDTYKTWPKLVKWFEDQSGFTMHLHQVWDERKPLLTFFSNHEIPRVTEDMWEFINALLDDIGYPKDIEPMWYLDRRLDKTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZX0</accession>
    <name>A0A2G8RZX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZX0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZX0"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL27034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="37307" checksum="43914D7BEC9CDD8C" modified="2018-01-31" version="1">MLVAHVRLNRIPHWHLRYDVRGASTFVAGVHKHHRSTTTHSTTAALRKTSTMPIPPALLTPDLLAPADGAYPQPRRGTLTGQSPPKVPTPTSVVEAAKRLAAWTAVDRHILPEHKVIGIGSGSTVPYVVERIVAQGKEVNKDRVFIPTGFQSKELIVKSQLLLGDVDQYPEIDVTIDGADEVDHDLNCIKGGGGCHLREKVLAEAADTFILVADYRKNSTVLGTTFPQGIPIEVVPFAYTKILQNLHLIGSPNASLRMAKSKAGPVVSDNGNFIIDAPFPEEIMKDPYTLLTRIKMLTGIVEVGLFCHMAKAAYFGNQDGSVTIKWHDGRIEKVAGNESAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0N9</accession>
    <name>A0A2G8S0N9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0N9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0N9"/>
    <dbReference type="OrthoDB" id="2756516at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="240" mass="26880" checksum="6B22E34316BB7EA8" modified="2018-01-31" version="1">MDESQPWSEKEVKEVDKIHSALTAELCDDPTVVIPDLGVRTPAQLEDYLARITSRPLAFVVKDIGTDVTGGGRAGKVRKADMARALVDWRLTQPKKSDQPDTTIISADVFETFHSVIRDTITPSWVSSVPHNFGSAAAGTPKADEWRTVFTIHLPLCLISLFGYPSADNPQLDQVLDHTLQLLPSLYPGLDCESIHHMAFHIYDFLELFGPVHSWWAFPFERLIGQLQRLPTNHKFGSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0P2</accession>
    <name>A0A2G8S0P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0P2"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="415" mass="45253" checksum="9927B5F8A5D5D4B8" modified="2018-01-31" version="1">MAIFNHPLYFYDTYPFDYSSEMFNPASAPPAVNDATNTKTNHLTRTSSLTDIRNLHGPSTTTTHSPPSSPLYVPYLDLWDENAFPPIDIPLPGTLIASQPLASSSALQPPYSSSSDAVEDNENDGDPSVQVPGPSDPRGIWEVSPLSLDADADGVLDGCIIAEVRYLKPSDAPLEPDFLGESEYARARRQLEFQQPPSNRLPGSPARPFGRVPAPSTEPTAATLNSLGSGTVVERPRRSQRENKRATPPVVDDKQTTTSTSGKGKGRAVAHEPVPTSSKVSGKSKRKREASGKDASAIAEVNSTQPPAFKKQKLSTKEVEKMMTVAAMVGHFASYHYSENERKSEEKLRCRWGECEKELTYGQLVRHVKADHIDARWPCLDCGMKFTRPNGVSRHKSSESACTKNQAAATSRACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0V1</accession>
    <name>A0A2G8S0V1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0V1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0V1"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="25"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="504" mass="54670" checksum="F6A4C448767E47A6" modified="2018-01-31" version="1">MGLSGRKTKQRIPNDPRNLAWANDANKFGAAYLAKFGWDPSGGLGVSGEGRTKALSVTQKLDMLGIGADHKNSAEGLAWKQNKDFESLLRRLNAANGDGEEEETRMKVDGFTKGADMSTLEDKATTAQGEGRDEAEGAEERKSKKKRKKDADAEEGEREKKFKKKRSSDHHSDSEGETKSKKRKSKKGETEVEAVAPAVPDSETFTPSSTPASRSVVPNRHPRAAFRARHMAAKSRASTSSAALAEILGIADSGSATPVTPSSVPTPYPPTPFEAGPSTSSSNPSGAATPATPAEEIKLQELTVSNKSVMDYFKEKLAAKSHPASSSGTPAPVEEENDYDQRPRMGLGASRLRQEISLDAEERRGLGGIGNGSRLSFASMFTSAAVPRSAEVVTGPETQPEVNEDADAASKKSKDKKDKERKKEQKSRKEKGKDKEVIEVESVEENRDAADEKAVRKRRKEEKRRRKEAEAQTSVADDVDGGDLPSSENMERRGKSKKRSKTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S142</accession>
    <name>A0A2G8S142_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_10640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S142"/>
    <dbReference type="STRING" id="1077348.A0A2G8S142"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL27489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="572" mass="65230" checksum="EFD2C7CBF19DE005" modified="2018-01-31" version="1">MRFAAPRSPSPSPTRSNRRHRSRSTFGVPSDSSSEDETNGSDSESPSSSEEEWLSSGTGVQTSKPRKQKSLAEQWLMEDTLASVRRRINHHDPYEEWEKETRQEAFRVARQKHAQDCVQQRNARDERRAQDDQRRAALHALELKEVESQLAAMNLQKQQEEATLRAQWQERDRQLWARIDAVIKKEEERLRVKQEEERKKREAEERVKREAEEKKRQEEERKRKEEEDKRKQKEKEEEEERTKLVAAQAQKERELAEAEARKALGHTTAFEDWKRARDTLRTLKAGPMKVVKQDKSLKSIWSAGRRAITPKVGQLTNDMDVIVRVSHEVVNILRPSAAHPPPVYLALLSSLAKAILMQAETEVTAEKKSAIPLAQLTVNLLMALDGFADIFWAKLCQRAGGWPVPIAVPPKDVDGTAFTPQTQRKAHGFRDSDELESIGDYTSRVTGILRVYFTVLVLPVNQPLDPLFRTPRYWSYFSRMLKDPHLLENPTAAQVMFTALDIGGLIACEVWGSQWTRLLALLFEGVTVGYHGMEGRLIGGKSPEGNASRTRLQLEVERIMTAASTMAVGFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1L0</accession>
    <name>A0A2G8S1L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1L0"/>
    <dbReference type="OrthoDB" id="2757361at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="189"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="413" mass="45618" checksum="F732B12FC861F763" modified="2018-01-31" version="1">MVFAFSFGAFGDIVTAADLALRVSKALSSSKGSTYDYQYLIQELDALAHILRVAEAATQTGLLERTTVNNINAEVLRCRDVIERLSEQVRKYQKALGSGGQATGTIEASWRKIGWGLFKTEEVRETRAKLTTHRLNLIMLMTACNQSRLDKVLGQNAQLESSMDVVTTHVKELSVVMRQLPTKLGYARPNAITIHDPFGTSTLLPMALCESPRQFDDMLALVSAKWPMLMRQTIKTGQYVPICVEAGARLDHADEGEWMASVVPGRTIRISYLVDWHPTSMTGQALGKLLQFVVCPDCERGGGPRQLLPPQGQTQLMVVGCSSEAADWKVSVEDVWNAQVNAPVLRCTFHHPTFPGCKADYASVAVAVLRDNEMAAMGDYCNALMKFLMQRFGIRDTRKCIHALGARGTQIHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3R3</accession>
    <name>A0A2G8S3R3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3R3"/>
    <dbReference type="OrthoDB" id="10679636at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="447" mass="48977" checksum="BBA98C2823E14DE6" modified="2018-01-31" version="1">MPDTRFALNHINPPPRADMCSSTTSTPSEQHSISPIAMSSDALTRPVTRTETLGAGLVSVRVNESNCPLFGSTATSTGSPEQRKRPREDEEENPESPKRPCLSQELGGEEYEDHKDKENSDPAGVSSLLTVLDAVAERLSLEDSAPTPSVAASPLGPSHTTNTGPPTTNPPVDPHPMCKSARSKPVLAKESFKGILRPQPFRRFPTTKNAERVVLRNNLRDIYLGNKARPTNVRYARDAPPRPRPRGTHSSNAAHRGPLTQPLPQKKYQYRFLSDTYHARLGLPPGGPVDPALFLGARPERGSPYADSDWTKDTEMSENGLELSPGRPLRARGQPVRIPCFRIASKRPGFRWHAPILPSPVAREDWARMEMAWRALLRKRKEELKARGARKGPGKPASRGRGPGGKPGPVPPIPVVRSKLGEELWRWSVEGSRGDEGDTNGVEVNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S455</accession>
    <name>A0A2G8S455_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S455"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654724" evidence="1">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="36418" checksum="513CF34610487257" modified="2018-01-31" version="1">MRTVLSTLSLLLSFLSARALRLPEADYSQHVLAPPQADDNNGIHLAVSPACGPLSGAVSDVNAGVDLKRIKTIVAFGDSYTDGGRTDGGPLAPPVVTPPDAGAGGRSTDGKVWVENLADDIGATLMDYAQSGACTDLSLWPSAIRKVDFLGQMRTFLGQSNALDPNSTLYVVFFGINDFDDSRRDGEANLQAAAQVILSQIRILASVPTNARNFLLADVYGLGTHSPAGDAMVQTVFSGLYDLHRGVNSTGRGEGIGGQAPGPALNVAFSQFGRIWDGVFGEPGYKAFGYASTEACIRICCVTTGMCDDPEHYFYYIPNHPSKEGMRIIADYAEQVLERCAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4J0</accession>
    <name>A0A2G8S4J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4J0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4J0"/>
    <dbReference type="OrthoDB" id="2762307at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="204"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="645" mass="73207" checksum="F569598E6AEBD289" modified="2018-01-31" version="1">MGPVVRRTLPSNYSPRPPRANLQRIWDDPELSPKIRDACRLARQKGYRYIWIDSCCIDKSSSSELSEAINSMYKWYGLAAVCYVYLADVPPGQNPHYKRSAFRRSQWFTRGWTLQELIAPFWVEFVSKDWTPIGSKLALVDLVENVTKIDYKALLHLEPLEEFSIAQRLSWAAGRKTTRKEDRAYSLLGIFNIYMPILYGEGDHAFRRLQEEIMQRIPDQSLFAWGHRYLSFELSDRANRLKAPRATVQTHQRRQQLFALSPKSFKGCESIRTARRDTGKLRSSTTSNGHKISYTSTPYGISTELQMVPLTRDLLLHTIPHEDVQLDFSGSPEGSQWYLAILRCDHGEHPGHFWGRVCHITSSEEFDVQFVFTGQIRVDCLGLFDLFLLSPETIEHYRQHMELKTVYIPHSYRATLPWAVPWSLQHQPYTAIKLLLLRDTRNALRARGYSAHLLDPDPDHPTTHRLALSKDEYTIIVAFHHTLEDDGKKFTIEARAEIKMSESCAQLDSAAPDSDQADLHTVSWTPRSPWMTKLAAKEVSLSAMGAETLTLDLRLDFAGSGYYILRVDVLSDATPASPAVNQAADPADDGSGVSTAEVSLAGEANWEEAEEEGGREVTSAGTWDVGAVRDDRIKHWNASCFCVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4W5</accession>
    <name>A0A2G8S4W5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4W5"/>
    <dbReference type="OrthoDB" id="2748713at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58881" checksum="B0EBC32ADCA6658A" modified="2018-01-31" version="1">MLRTRPIVLRLKNVATILGFHDFLFSDLADRLPHVVALVIHVAEGETHPSTECSGRAIEALVAILRDASSLKSLELRSSAEWQSLGYLDDLRLSAVIEEVASLRELTIGGRTEVANFIGAIRSPLTKLAVGVSISEVRLDEGQWSPDSFGAALSRITPSLQTLAITKSYVRLIGGPPDSVSALTPFHALRSLTLSWLVVVPQLPLLFALSPNLDGTLHITMLIHGSPVSAGLEERYNFFRTAREQNSLAQEHKCWTRLHRLICDVEALFALSLRCPVGLTIVHECPTHAVPATRRYITESFRDHPPTHLNLQPMIWWGPDEPSLAGMFPPEAAATLTHLTLCVQCDYDSVPGATPLLEEMLRWDDLWRGTFLPALAPLRSLTHFRLVFHCEAREPEVPAWPISEDPFVEDLRPTGGTSRFDFAAMAAALVDALPALRYCFLTNSARLVEMKLSAGRTFVERWRESRAWRVACTPTGLDGVDDLQAVAAVDAYETRRELVELDDDIAEAIIDRGDLVLSTEEKASAVNRSSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5Z4</accession>
    <name>A0A2G8S5Z4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RENT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5Z4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5Z4"/>
    <dbReference type="OrthoDB" id="18087at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12455">
        <property type="entry name" value="RRM_like_Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039722">
        <property type="entry name" value="Upf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005120">
        <property type="entry name" value="UPF3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112:SF0">
        <property type="entry name" value="FI21285P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13112">
        <property type="entry name" value="UPF3 REGULATOR OF NONSENSE TRANSCRIPTS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03467">
        <property type="entry name" value="Smg4_UPF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF3" evidence="6">
        <location>
            <begin position="35"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="500" mass="51969" checksum="0FB469B5DF8CE613" modified="2018-01-31" version="1">MSTAEASRPPKSKGKDKEKEKKSKSSGSGQKSQTERLKTVVRRLPPNLPEDVFWQSVGKWVSEETVSWRAYYPGKFKTRLNKENIPSRAYIAFRNEQILASFSREYDGHVFRDKNGNESIAVVEFAPFQKVPNEKKKADSRAGTIEKDEDYVSFLESLKEVSTKPFDADTLETLIASTQPAPLPTTTPLLEALKAEKSAQKDKEAILRNHAHYKDPAALAAAAASTKKGDKKKEGAGGPSAKEKAGDSVAGPSKKGPKKGVTGAKAAAQQQQGQVQSGASKDTKGPGAKQGASKPPKPPRERKGGSSTPGAAPAASSSSSAPASAPTATSTSTAAASAPGDSAPAPSRRSRPVLGLASRQFEAALSGAGVERKSRREREKEREKDKEKEKDSGASTSTATVTAAAEGSSAPAPKAKEEKRERGSRRGGAPPTILQRDAAPKILARPAEGQGAAEGSAPGAGAASGNATEGGEPVASGGAGRGRGRGRGRGRGRGASTQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7G6</accession>
    <name>A0A2G8S7G6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7G6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7G6"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013916723" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="23789" checksum="2034B5245DF99B60" modified="2018-01-31" version="1">MRFPKLSAVTFELLVPLFVSSIALGATINKRAATFFDPALGGGSMFIDAGNGLGEPMNVIISGLSSPDVLTLDGVINFARAIGFSEECLGIHLGNPFSANLGDGHGAVNQSIELRQDFGSAALGTCLESLIGGNHFRVFFQNGPLADSGAVFLAVSKEEDLEEGHTIVPDGYDVGRDLLVQNAVGTKCFGGVTYSTTAQNITGLMAAGSEGVNHGIAVDGIVTLLTVNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S856</accession>
    <name>A0A2G8S856_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrD-like helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07852</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S856"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="358"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="379"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1585" mass="180812" checksum="B116A9988EEB6212" modified="2018-01-31" version="1">MSDVSAILFDAQELEDALQHSFSAFQNIVSRLVGLGRLEGVLAALNDDTYALLTREVEQRFPPTAEQFISSTHSILVSSFAARLPDAIPASKGELVQRLNECWKAVVLARAVLSEIAATSTANTPNRVSTLHAKPFSDLGCPVPSTPRELATLEAEILRDQGDVLKYFLDVLRGPAREDVIARQRELHELEAAAAHAPRSSTPDNAAMAPVVESPTALVLTSRAVSETGAAPRPAYIPKAALYVENVEGFGEWEVFCTDHANKELRKLRKESKDVFLMVLKKIRCRARSQPRGSANNIFKPVEFFPEVREESEELDEPTTSKDLDDKDYETILSMHRQVQFSKALFNSFLVGHDLQFMYRPSATEAEIIEHPSSCYIIGRSGTGKTLTMMYKIISVERGWCTASWYLPRPRQLFVTRSGMLSRQVQRTVGQILESFRLADMTQQELVDIWRRKAESAEHCRPLPRKWSELEDDHFPLMISFDKLRELLEADFTEAGLLKVRTGELEDEDLDETSFISAGRFIKTYWDHLPKSAVKGFDPASVFGEIMGVIKGSEGTVNTAHGYLDREAYLKLGERSHPTFAALRDKVYDIFHRYLSLKRRRYERDDADRTHDLLSLLKVHGLPGKPVDFLFNDEAQDNLIIDMLLLRSLCNNPNGLCWAGDTAQTIALGSSFKFSELTSTMYSIEKRNLKPSYWHSYAPPRMFHLTVNYRSHAGIINCAQMIVDILTTTWSDSIDRLDPDRGWRKGPKPKFVRRSGFRELFQFTNKDHINVRSEFSSGQCIIVRDDASRKELFSRGTPGGQVMTVYQSKGLEFNDVFLWHFFESSEPSKRDWECVCEEFQGTPLPLHKTTEQYRNLKALYVAITRARNRLWIIEAEDSDKADPMLTLWTAEDAVEVTEASIPVDVPVEPDTEGWAAQGRVQMDKQNFDQAKYAFGRAGPGFERESKIAQAYIDREVAITEEEFRAAASSFERCAMSSEGMPDHRELALSAAACYTRARAFTESARLYHSVCEYTKCTRQYIRATMMERARQVVLEHKNDVDELVVKRVCVYFLDQSEYEPIEELFINDEESLTQFMRRHNLLPQLADYFEHLGQFCEAAEIHLGCHGIPKAIELFFRGNKATSVARGTSTLLDELRRRYTLGQPVDENFKDFKKLNGLLSRRKDLLNTYPVLPSDESQTDLLWKIRLYWMSSLSNCLHIPFFALGTPLMFPSLEPELALKFSEASRVVTTWINTIMYLTSTPDSPSSISSEVRSQVIPCAALLGYMLDILRDCPHTASMVIPLELWYWYGPSYRRHIEQLHKYARVVETGRAQMPGALLYLRFLLQVDGHPQGREAIITYIAEGLATAFVLAKPPVSNRRTLHNVILGRRWLRTLFDPERWDSSEALPPHDRRHINEFVKLLRPLLQMLCSLRTGPAYLLLPSQLLVSNSISRVINSWVLVAREMERHEESRLSIMKTVKEIPQHRRPPHLQPFHGESVWDDLERAVWLSNGPGTTLTPADGLVHVQNEDIQDYPMDTPGTIDCVTYKGLDSLSSLLSVQPPLRAWTRIPFPPEWRFPKRRPVLVKRNDWVRSKPVLCFRGQPMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8V0</accession>
    <name>A0A2G8S8V0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8V0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8V0"/>
    <dbReference type="OrthoDB" id="2764599at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="102" mass="11203" checksum="9CF850F628BA00DD" modified="2018-01-31" version="1">MLVSRDWKRKDLCVRPPSPRPSPCVPYRRKANGTTVSELVMTPTCELTVQEHGTLEELGELFGILSVAVYGRMDDGPQIIALKDLNKGGMTTHIVVGTPGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S901</accession>
    <name>A0A2G8S901_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_07411</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S901"/>
    <dbReference type="STRING" id="1077348.A0A2G8S901"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL30234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="318" mass="35445" checksum="AA58DA71BDF9B724" modified="2018-01-31" version="1">MKESDLERRFRVLHWQKDHEENHRERLKGRAIGSQFEQRRSFASYVERLTDLFSNWVTGGTTNRLANDGTQNDLLQFILDKAKSNNDTVSTIAQRVLGLNFAAIHTTSVLFQTATHALTRLAEHPELLAPLRDEIEKSIAAEGGWTHAALANMWKLDSLLRETLRFHGIGLLEMGRKAMKDLTLRDGTFLPRGTIVHTAAHALHHDSAVLEHADVFDAFRYARMRTAGRGAGAKLQFSATTTSPEYLPFGHGAHACPGRYFADNVLKAVIAHLILKYDMKLGGDGVRPADVFIAMGVLPAPQSRVLFRPRKHGGDPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S931</accession>
    <name>A0A2G8S931_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_07448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S931"/>
    <dbReference type="STRING" id="1077348.A0A2G8S931"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="501" mass="55330" checksum="A2C1CEC7E97C031B" modified="2018-01-31" version="1">MDDYRQVALALLAAGIATYAVRWYTDPLRAIPTVGGSSLPGLSWLAAFRMLGDCRDVLEEGYRKAHGTFKIPALDRWMVVVSGRELVEELRKRGDEELSAPGGSQESRYIFEPEVLADEYHVEVVKEKLTRKLPAVLPDVIDEVTVAVKDHIVTREDEWTSVEVMPVMQKIIARVSNRAFVGLPLCRNEEYLSLAVDFAVDFMKSVIVLRLFPGFLKPIVALFYNLVKQDTARAVPFLRPIIEARQRAAVDLGEGWNDKPTDLLQFLLDKATPKNESVFAIAQRLLTLNFAAIHTSSNTITHALTHLAEEPELVEPLRDEIEKSIAADGWTGAALANMWMLDSLLRETLRFHGIGLLAMGRKAMKDLTLRDGTHVPRGALVQVAAYATHHDSALLARADAFDAFRYARMRSGEGGGGGARQQFTSTSAEYVPFGHGAHACPGRYFAANELKAMLAYVVLNYDLRLGGDGAREPDVFVAMAAVPAPTTRVLFRKRGGGSQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9J7</accession>
    <name>A0A2G8S9J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_07142</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9J7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9J7"/>
    <dbReference type="OrthoDB" id="2792843at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="767"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="848" mass="94724" checksum="A50118578ADC8036" modified="2018-01-31" version="1">MSKKGRAQGSSSKSRAAPSTTSGAKKSLTAGATSSAKSGAGVPGTKNGPGAGAKKKHAAVKSRKEVNNEDKLEQDGFVLVDEQDSGDEGTSSESEPEVDEAAVLKAMQQRWPSTIYAFYKPTPKIQYEGSRCAHIFKCANRGCDVTVRHFLDKKDHSSTSNLRAHAVKCWGPETVTAAAEVASVQVVRKEIVGSILKTGSITAHFEYKASQITYSTRQHSRTEMCVEIVKWVCESLRAFRIVEDPGFKVLMKTGRPGYYLPSTSTVARDVADVFQQSRSQIAKMLQEHEGALHFGTDAWTSPNHRAFVAVTVHFEQQGKPMCFLLDVIEVACSHTGVNLAAAFARILKEFGIDHKIKAVTWDNVSNNDTMVKELAMDKNLPVFEGIAARIRCFLHILNIVDGKNLVCLFDTRVQKKKGDGKEEDDLEIAELVVAAGAEDAPDEDAVEGKGAEEDEEQEYDPDVVLDGEEEVHAIGEMTAAEKAEFTLAVHPVKLLLAKIRMFTSKVVNSSTILLPAWKEAIALHGLLERLIPRNVRTRWNSTYNMLAMVLEYHLPYKQMCERTDNGLRGYKLLDEEWGVATQLEKVLKVFKHTTLFFSRTTPNLAQVIPVMDHIDKVLTNASRSNKYAKAIRVACGLAKEALNKYYSYMDMSDTYWITMMLHPSHKLQYFKKLWWTAEWQKTACELLQEEYERTYANNGNGEDDEMHEQDNDDEAPARGSKAASSVSSHEDVSESDEDDFDDLPDDENIFDALALITRLQVSEKGDELERYLAVPVEPTEDPLLWWADCRALYPRLFRMALDYLSITVGFVNHSDLQKAAQAVNINDDDAPFELTPGWDRVDVNVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAM8</accession>
    <name>A0A2G8SAM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAM8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAM8"/>
    <dbReference type="OrthoDB" id="2747112at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="684"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="829" mass="92541" checksum="946B1F39986D4916" modified="2018-01-31" version="1">MLNREGRLDRREDKRTDRKENVDCKGIMLTASSTSSSSRPKRHRSSHPEDTATASQADAAVPKDVESTSRHNGVSKRRKPNTVPTGAAAVARGEESNPSKDVVDDQLEPDADATNGGVDAVRACVRRTCKMRLLSTEEKRNRFLVKYAGMTPEQILDAIARGWRSKVYEHFQSPTILRGEQGSVTYRFICKRFPSKHVDHTNYEDSTSNLKCHVDTCDPDPTLESEAITAFANGATYSSARMRFLLAMWCTSCHHPFKVVEDPEFRAMLGMLYGKVQIPSCITVSHDVQLILDETMAQLMDQFENLQGKIHLCVDGWTSPNVMNFLSVTAHWQEAGAMHHIILDFIRLTKSHTSKYLSRKLLECIASINDKMLDEMTKEFLLFRGKKVRVRCFGHVLNLIVKACISGFQGRHSHDKFKNEFETAFCDIKAEPLCDMQELTNDEYEDEVSENEADDAHEQADEEVIASVDNTHPELTDTSDKYAAILKLSAKVWNNLNVRAEMSRLAKEAGLQSEVLVCPITTCWNTICAVLECALDMQEVATELLDPFVFATRQISSSDRALVHEVIPYMDALTEHLDKFSNDESLTPTVHMAAKRRRVVLDKYYGLTNETIIYHIAMILHPRYKMNYFWTQEWLEEWISEAGKAPTSAGPSRVPGRRSAATSSSRALFESIARGPSAENQDALEAYLEAPPLTMVKDPIKYWKLRAQMESNPALARMALDFLSVPATSTDIEHAFSHGCLTMSQLRYVLGNKSMHASTLLGSWVRSPGLVDEGKIVDIIKNSGVVPLATLVVPAAPVTVGSESDSDVEVVAGPSSSSRSVVTHRTSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAZ0</accession>
    <name>A0A2G8SAZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAZ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAZ0"/>
    <dbReference type="OrthoDB" id="19908at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="39"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="266" mass="29317" checksum="D5E93C1878C9D34F" modified="2018-01-31" version="1">MSLPPIFYHCFKSPVPYTKALALQERIHAHQLLARKTSQTHRDYLLLLEHRPVYTFGRRQLESSEEIASEAARLRGLGADCVSTKRGGETTYHGPGQVVGYPLLDLGRTSPPVGIREYICKLQKTLEAHLLEAHGIQHIPSEHTGVFLDPYTKVASIGVQVRHRLTTHGFAMNITDEPLVWFNRVVACGLTDVKAGSIAKFSKTGGDPSSISVAAELAGLISRFGRITGRELVELDVSERGEVEDAIRTAEHDAVKIGPWSRIPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB83</accession>
    <name>A0A2G8SB83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_05704</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB83"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB83"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL31011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="477" mass="52135" checksum="3E7800DA81C2194F" modified="2018-01-31" version="1">MSGFRFLNLVRPFLPILPEVSSPDRKVPFNQKVLWTAVTLLIFLVCSQVPLYGIMSSDSADPLYWMRVILASNRGTLMELGITPIVTSGMIIQLLAGANLIEVDFSLKEDRALFSGAQKLFALTLALGHATVYVLTGMYGQPSDLGAGICLLLIIQLCSASLIVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTVNTGRGPEFEGAVVSLFHLLFTWNDKGRALREAFWRDRLPNIMNLIATFAVFAVVIYLQGFRIEIPVKSNRFRGQRGSYPVKLFYTSNMPIMLESALTSNVFIISQMLSNRFPNSFLVRLLGVWEPLENSPQLAAVSGIAYYMSPPHTLRAVLLDPIHTVAYIAFTVTACAIFSKTWIEVSGSGPRDIAKQLKEQQMVMAGHREGSMYKELKRVVPTAAALGGAILGLLSVVADLMGAIGSGTGILMAVTIIYGYWEIGMRESGGPEMAALGELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBB7</accession>
    <name>A0A2G8SBB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBB7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBB7"/>
    <dbReference type="OrthoDB" id="2742110at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40871" checksum="3CBD8C987C6484E1" modified="2018-01-31" version="1">MLYHDLLRRIFELMDNQPGEYIKPRQASAVNTWASTALVCRQWTLPAQSALYARVFITIMSNPERNARAILFARTMHTAPHLRALLKHFSLTVKGVAVLPPELVDWVAHVPEGSLLSLESSLEHRPQPAQLALYAAPAIRGLRALTLRGHHPRELLTALGALPRLEALTIQFDDLVKKADTWAGVQLALPPTVRTVRIDACTERYLLPAVDLIRRAAAAPHVRVLKLRLVDPVVHAGAPAIAQALLQVSPHLWELRLSSVPWAPQVQLPFVDELVLRAPALERLDCVLGTFSDALFARLPASVRDFRIALWGAEFFPHEAGLANLLERVGQGGMALTEMEIFAKSAAVRSQLAGLGDACARRGVTLRWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBL5</accession>
    <name>A0A2G8SBL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBL5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBL5"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="14736" checksum="3B600791C04A725B" modified="2018-01-31" version="1">MNDGHPTITIDLVLDRLQTKEVLRAILHSILFHRLFGTVRSRTFEVLDVTMEEVPWEQWIINAEIRQPSERERQKFNSDLASTLTKSLQTMLMHASSERGRSAVPLITNAQSISPFPIKITVKVGGVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBQ0</accession>
    <name>A0A2G8SBQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBQ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBQ0"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="128"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="226"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="372" mass="38761" checksum="C91F219D3085E885" modified="2018-01-31" version="1">MTKPEANGAVFRLLDLQLGEIDMSSPPEGYTVRLVAAGWETSYVVLSCPDHSDLLLSFGANDFGNLGVGPPNAKPTSKKHRIHVVDLLRALDASPVPPSTITVLALSTGPHHVLAHIRQRDPTGSSLTHFLGWGASRHGQLGPILDPAGRPLPTCPSPIPILCAARSDADAALALGTQHTVCLRASGGLVGLGSNRRGQLEGLAGLADVVQVACTWNGTYALLRDGRVLATGSNTHAQLGRGVAEGGGGGGGLGPVVFPFDVDVSAGTHAAAKLVCGSEHVLCLVDVSVAGPEGEERKKRKREVWGWGWNEHGNLGIGGTTDVNVPVRIWPPHTDDARAHLDGDDTTRSRGSTGGVLDVWAGCGTSWILIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCJ4</accession>
    <name>A0A2G8SCJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06181</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCJ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCJ4"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="455"/>
            <end position="459"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="569" mass="62392" checksum="458F5862EC64613A" modified="2018-01-31" version="1">MLRTSLRVRGVTRILAPGSRAMSSIPSLPLTPPTPQEEAAQFEARIADIEAFFAQHRFASIKRPYTAAQVASKQGSMHILPLPSTLLANKLYALFEKAASEGKPVHTMGAIDPVQMTQMAPHQEVVYVSGWAASSVLTTGNNDVGPDLGDYPYTTVPNQVHRIFRAQQLHDKKHYDERWLATPEARAKMPYIDYLRPIIADADMGHGGLSAVMKLVKLFAESGASAIHLEDQLVGGKKCGHLAGKVLVPASAHISRLIAARFQLDLLKSTMLLIARTDAEGAKLLSSNVDVLDHEFIKGVSAPDRALAEVIAKAEAEGRSGAEIDKIEADWLARNPLCTFNEAFEKALEKSSVSDKEGALKAYREAADGASNADARDIAKDILGEPIFWDWDLPKTREGYYHYTGGVEAAIKRELAFAPYADMIWLETKLPDVEQAKYFSRKIREKYPGKWFVYNLSPSFNWLGQGFSDATLKNFVWDLGKEGFVLQLISLAGLHLNAVTAAELASAFKTDGMLAYVNLIQKKEKEIGCDVLTHQKWSGANYIDRILTTVSAGSSSTSAVGKDSTEHSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCS2</accession>
    <name>A0A2G8SCS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06277</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCS2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCS2"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01871">
        <property type="entry name" value="Rac1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="196" mass="21544" checksum="0C43CAD3A3E47E76" modified="2018-01-31" version="1">MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKTISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPPSFENVRTKWYPEISHHAPSTSIVLVGTKLDLREDPATIEKLRDRRMAPIQYSQGVQMARDIGAVKYLECSALTQKGLKTVFDEAIRAVLNPPPQPAKKGSKGSKCIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCY1</accession>
    <name>A0A2G8SCY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_06305</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCY1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCY1"/>
    <dbReference type="OrthoDB" id="5549158at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="129"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL31603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="305" mass="33080" checksum="6B2BE77B3D24C9F0" modified="2018-01-31" version="1">MATPDRQDLVRNAVSFLSDPKAQAAPLAQRVQFLEAKGLTAPEIEEAMRQAGANQTVPSPAYGPSAYAPAYGPMPYNPVQLPPSQWDWRDYFITAVVSGAIAYGAAALFRKYVSPHLRPPSATAYEQDKDAMAAQFDAAEALLKEIQAETAAVRAAVEEQNEKVSKVTQEVEGVIKNMRDGEARTRDEMREIREEVNNVREMLPKVRFCLFMIEKNKESHNQSLAELQQELRSLKALLLSRGPGISTGPSTPILPGKPSIPAWQLAGGSSAQSVSTPSTPPPMLPPTTVLNGKGKDVAVTESETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCZ7</accession>
    <name>A0A2G8SCZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UreD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCZ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCZ7"/>
    <dbReference type="OrthoDB" id="5550464at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01384">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002669">
        <property type="entry name" value="UreD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33643:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01774">
        <property type="entry name" value="UreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33134" checksum="EF4E76974DB98E5D" modified="2018-01-31" version="1">MAPTKIEQGHGRIVLRNDASGNVFSELAATYPLKLLAPRLPSQNVSIVYMLSYGGGLVGGDRIRLDVEVHDAACLAILSQGSTKVFKTRPGQRLSANDHIHPVTAQSLNVRVAPACALFLLPDPVTCFRDAKYHQIQTFHLSKNSSAVLLDWVTSGRKSLGEEWVFSRYYSLIEVFVDNDRIAKDAMLLDERNPDGSPFTHRSLADSLAPYSCYATVIIYGPLVRDVMQHLSAAYTAITVFKQHAPPSLLWSFSPICSGEGCIVRVAAKETEYVKHWLGKALWDLEKILGIDVYRRAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD15</accession>
    <name>A0A2G8SD15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06368</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD15"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD15"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="422"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="555"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="887"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="986" mass="106392" checksum="A1D5493265158A6C" modified="2018-01-31" version="1">MSVPRSQSVPHFTSTSLRRTKIPPVATVTATGVTDDHAYAHPKLPRHRSAVAISGTKHLASVYTPRVEREDPFSLSGFFPANLPAHEHSVADQGSWEWLRASSDYDSEYRSSYPSPVSESDDEWNIPTPWSPDEVDAFTRDAIKREDKLGILALSSDTLFLPARGDELYVEERGVLSPFTRAGDPLDADAVVDALRALRTAYSLPSGSAVKDESAALHELFSPEKESGDKVKVEAEGWEAVVAWGLRPTMRTIMPFASNPLHLQMSPTQTTEAREHIPTSLNPQDLSRSASPQQSNLSLLVSNGHAALRSPPAGVAHPPIPPGNQPPPPSEPSVSIQSILSNPSPAAALPNGHPPSWTTSNASSRDSGHAIAGPSSGTGAPQRTSTKRKLEPPDAADPHTKIRRVVRDHITQDPARVMPMTTVICLHAAVAQKSYGSEKRFLCPPPVVHIEGPVWQMKHQHLSMAVVNEGGERTCELKAPMDHALTASFKFLHVTGSAKSKSFQLSLDIAEPSPNAPDGGEATGNERVWASFDSAPVTIISKPSKKTAKTRNISSCILAGGPVSLFNRINSQTVRTKYMTIEHNQLCASNIAWSAFAVNVVRPQGNENPLGGPQPVTYGSEIVLADTVTGVQTAPLIIRKVDKGRIVPDDGGPVSQMQKIALQRVNGDGTRHYLSAAGPIPGTPGVTVPPAPGLSNQAGTHPLLFQSPRIREEMKDGVRVITDEVDDYLCWTIVGISKFQYTFFDAFGMNNSVPEMPITPFPTLFNTPIYRSQSNTLEMMAANFFYMDPKTKTQMPLDVYIGNIGPLRLRIYNHSPLAMDGRFDPSMPFIPVPPLPNQPGVPVIAADIAHENKPADVVLSLPARHLHMMIVAEMPPMPDILKALREDALPPGGDASDKSQDASGGRGSNLMRDIAGRSLPLLFIRSYDGVGYHSGRVIAADNVLHAMDLSNPARSGAEGGDWLAAAQAAARMSDDTSMHGWNLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDC0</accession>
    <name>A0A2G8SDC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDC0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDC0"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08577">
        <property type="entry name" value="PI-PLCc_GDPD_SF_unchar3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039559">
        <property type="entry name" value="AIM6_PI-PLC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013600728" evidence="2">
        <location>
            <begin position="22"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="311" mass="33517" checksum="01D611E6027611E6" modified="2018-01-31" version="1">MKLGALQSLLAFLGRLALVQAKATVGQAIATLENSNSSLLQYPTQFTQNIVPKQIHSHNDYWRDVPFLTALSYGVASVEADVYLINGTLFVGHETQALTKDRTFDALYIQPILQVLRLTNHKSAFTGNGNSANGVFDTNSGFPLQLLVDVKGDGPTTLPAILQALQPLRAEGYLTTFADGMLSQSAVTVVGTGNTPLEGVKALEPRDFFYDAPLTQLNDPSLNTTFDATISPLASTDWATAVGWSGIGTISEGQLANLTQFVGDAHALGIKARFWDTPEWPIFARNAIWKVLAENGADWLNADDLEAASSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDP7</accession>
    <name>A0A2G8SDP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDP7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDP7"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF90">
        <property type="entry name" value="CORA METAL ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="689"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="762" mass="84547" checksum="F79CDDD3E324160A" modified="2018-01-31" version="1">MSPQDEPSSSVQPPQPAEVYGHVPNSVELTDGSDSEREDQDIYRGAPPTFVPARTPSPAPTTSSSSSSSSSSSSASVFRGRLGAISAGVEHAISRWARAWLSSSSLSSVSSTSYSSSASHGKSQTTRRRKRRPRSIATTIHNARSEREVAARIRARQDLRTIPRGFVFYTPKLVPVTAKSQAAAERRAARIALVNQDPILRTTDLDEVTARLNVVLRERAKAHRVRSDPLPSAPSAGTMFSSSPPLRAVSLPLQDYMLSDQSAVAQSTPILPTSSSTSRKDKEKGGKGKQRPPFIEASSSTMLPPPKTTTVQLEPQRVAKAWWLDVSSPSWEDMCQIGKLLGLHPLTLEDILTQDPREKLELFPRLGYYFLSFRAIESRKTRDRLRNMLSEDAANADDEGIVGEVNMYLVVFREGICSFHFADIEEHIDRVRHRIMLLDESSNASSDWIAHGLLDSIVDSYFPYLEVIEKEASEMDRRIFSAGERGDVAEDVPPIIPEHSSAFESGRATSNKNSTSADLDEKEPASLPHLTKATSIKSNRLRLRFVSPIKLPMTMRRAKRAIAELFASIPRFKAVDTKAPGYHHPTNTVTRMAHIRRLVTSLARFLAVKSEVVAQVKKRLLTKGEWGLGTGMEDDLNIFVYMGDVQDHILTLQQSLVHYERMLSQSHPTFLSQLRFSVNRAKSDSDKAVMFLTAISLGVVCVQTLIGLFSLNVLVPHNDLAGTKYNGFAIVLAASVVIVIVYSTIVRYWWTQAKRRRFNLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF89</accession>
    <name>A0A2G8SF89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF89"/>
    <dbReference type="OrthoDB" id="2757774at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="62094" checksum="E34A942D9341060B" modified="2018-01-31" version="1">MAHLNLDVLREICGFLTDVPDVLSFSLTCSTLRAAAVERRLSMRDITIWSAESIRDLYNFIFVDENRRGRHIQAITIPVHSDIPPEPSEELINALVSVLASATRARRFSFYFPVPDEWSATEGSDELEVSCLFCHRKILSAVAEMVSLHELRVVAQTDIAGYFLQSTRSTLKVFWHGDVDGDSHEQFPVTVAPQLIPALQEIALTFELFEFAMTSTPCMSLPAVRSVTLTDVFEPFKLDMLLTAFPNLDDTLIIADNLYTFNNGHLRRSREENREAQKRYTWKALDRVAASAVMLYALGLTCPVRHLTLNPAPVLNPRRPQATGNAGVALRESASSRFALLGLRLPLGNSILGGSLFVADTVARLTHLVLEARYMSPPGIVATPGWETDSEEEDNMSWDDILDTLVAGVDVLRLTHIHIVVSCDVESSWGPFSTAIYDGTRHFSFDRLLTALPNAMPSLTYIVITSSGLLCNIETNERETWRTCRAWRVRRPPVGIAESLLESHELEELSSMEGEALINKEELNGTTKAELHRWKTVEILSNLIVELEVEVAKGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFE7</accession>
    <name>A0A2G8SFE7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFE7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFE7"/>
    <dbReference type="OrthoDB" id="2743659at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="154"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="315" mass="34523" checksum="3DEFF74C171FF3A9" modified="2018-01-31" version="1">MGFSPGGTLGGFFVGFTVSLFLTGMLVAQVGTFYRYHEPKPNAVTALIFVIFILENGHTVFMSIGAWDYMVSLHGNASQFHSPVVALGVLVYIATACNTFCRIIFAYSIYKLNGRRGLFPVIIVASTLIPFSPSGFDHICYFKTCFYVGTAAALTADILITASLVVVFARRGAGFGRHVLFVVSIYLCLILVYRTIKTTVPLLFYCLNTGVASSICVIGVLISYVISPTTFIWMSFYLVLGKVYTNSLLGFLNAREVIFVRGGANRQNMQQTTTAPLFTSIVTIDRSDTPDSQFYIDAAEDDPRGPAPVTTDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFH9</accession>
    <name>A0A2G8SFH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFH9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="101" mass="11154" checksum="94BFFD2147A584EE" modified="2018-01-31" version="1">MIEFPCGLAALWSILSVSHAVLDMDIRSSRLHDTLRIRFACCSLSLSSMLVVLGLSLAYSTVLFIIVHLRTLVYQILSLGLLLYPSLSLPRCPSLPAHTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFP5</accession>
    <name>A0A2G8SFP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFP5"/>
    <dbReference type="OrthoDB" id="2796682at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="3"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="649" mass="72209" checksum="87A1F785323639A3" modified="2018-01-31" version="1">MECATALKDHDDAKIQGWKEEIDTHLVFAGLFSAILTAFNIEAYKLLGGNNPSSNSSADTTNQLLALLVQQTATTNNLGNVLNTNATAFASKVFISAQQDASSNPTKPAASAIAINALWFSSLICSLAAASISILVKQWLNEYKSGMASVSLEVARIRQFRNDGLKKWRVQEIMMLLPILLQGALVLFLIGLILFLTPLDNKGAVTKAAIVLISSLLFFLGLTTLLPTFAQDCAYRSPQAWGVFVVIQSIKKPIRNVARRLYSLTTRMADRHADGTFSRLRVRMAKSFVRMFQRFANKPNTYSWKARERVLVEGQGRGLDQHLLVGADATFLDDTFLRNVIQPCLNDMEPLEAVNCYFRLMSHRAHRVEDGVQYFENKATESKAESLAILAEITLETIRKSREEPIPIEHPIQVLRTMEPLLVRTLPLVYPRFCEVMFGLLGDQETTVRRMGFSILYQQLSRNLDLAEQYAAAGCHHDLGALVAFVDGARRAGDVKDFLDGCDLVICLATLDALPSPDTAVRTHLRDTLVHLQAFLESPLWKNVQPRMLLYPISRITPHLVALERRYLGVLEDKLVEVLEQVVHHAKALNHDGNWEDKIIILETTLHDLRSVRLGGSSAGSVSTLNEDRAGHGRRPSFMRNALTPTLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFS7</accession>
    <name>A0A2G8SFS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SFS7"/>
    <dbReference type="OrthoDB" id="1262810at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052972">
        <property type="entry name" value="Sacsin_chaperone_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600:SF42">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="2240"/>
            <end position="2323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2393" mass="268254" checksum="520458487ED4C138" modified="2018-01-31" version="1">MLRKSLDVTPEWLTREVEREKLRSDVALALPINTSHNIQGRLFTFLPLPLTTNFPCHIHGIFSLTDSRQNLRNPSETIMQQTADALAVAWNRLLFDTLIPRTWLALLESIAAGHFSLSVYNCLPPLQDRNTSGDAAYWTSLLRNVVQLAHTSKARIWPLCTGSGDSSQTAMHASLEDAFIAIAQDEEQLCALTDAGLNIVDPPPSSLGGVLTEICPSRALTPQSARPVLARSDRIRRLPQPQKDLIIEFLLGSRDVHQLIGVPVFQLVSGMTAALEAKRAREQEAHVLLDEVAAELFRQVDANAISLHNIPAIARTLLLNHGSKHLNIQPLDSSHCISYILTAQANFCLERAARSLYGIGRWLSMTSSGGAWPWDRTVEWLAKLWGWVETCSFANTLQPHLKKLRLLPTVTGQVRSVEDQVFSHSSAVADDVRDALADLGVSILDPRIPIKFFECQTPRFTKSLSSASDLLAVLGSISSTVSGKAAVILREHLAGCLIDAPRLNEAQKVTLRRLPIHPVLTASAPPSVCRIPDNHSLQCVVDRASITIPLPSLLDTTFIECTANEQYRYLLEKLDYHAASWPLTTERILQLHVSHFTEQGPETRLAVLQYLTKHPLLLTTSMKEQLRFSSIVRVDRGARLLAPKDVVDPASSIADIVPPWDTSAIFADQGINSKITSALASLGLLRQDLDVEYVKARIIHVAQSPQGFELARKLLSTVDRTLFNCSQVRYDRDRAWIPTNDGLRRPQDCRDEIHGPLCNRVMPILNMQLQSTSLRRMLGWDEPIPLDTVIAQFRKILSEPHSPSRSEYLDLLTSEFGRRFKEATTSQLEDIASNPCQVSWVLTSTGELLRPLFAVFDLPGRLRGFGQVSLELARRPGVKEFLELMGCTVSPTNDAVLHQLQEPLLAQSVEQGSQQAIEGCVQLLQALDIPSLTVPQRERLLAPGTDCRLHEIHGLYYNDLGFRAFHLESPSDRIQVHHAMLHNLCVALQIPSLGSLHLQPLELDAENMREDLSTRIGNVLRSYDVEQAFNEFLANAADAGAKKFNIMLDHGGDRRAQPSEVLCPNMAQFCQGPAVIAHNDAEFTMDDIRGICRIGRGGKEDREGTIGRFGLGALSFYHFSEVAMILSGSYLLLLDPSSRYLPEDSRTNSLYPGHLKLFHNLFGFQVEHAHYNGTIIRLALRTETQAASSVLSKRSISTSEVRGMMDRYYAIAARSLFFIEVQDITALEARGTMPTLNWSVTAQREALQPTGNENDRRSLVRLHIDCCGPFAFPRSRQSSWLVVSTTILQEQIPERLRSAFDEHRFQHLNIALAARTSPKAVPTDDHASNFHFFSSLPLPIPTSLPVHLHASFILAADRRNIRWDGDGTLTRDECNHWLLSTALPPLYLRVIELLNLDGPFVSEVPTPWPGNKDRDLDPISKALVDAFYSDHLSVSTQQVFRGVTGRLLEPSKAVIRHTIPRVVKDVLHELHPDTLVELPHAVRSKVLTVPSIPRVSPQYVHDVIASSREQFLVICGKDTSTIPEIAQGLIRYMLLDDPKLSIPSASLHGLPLLPLSDGTLENIEAEGEQADRIYVGSWGSSLTPGRPWPLFSATRFLDPKVDQQLVLDQGWNVFPWDEAAVVALLQERIPESTRREVSETEREWTMAFWRFFDHSPLKQSELLNALNPFPLIPTNDERVFVSLEIATAFPAICLPSLSSEAWLVGPLQQIGVLIINIQPSSMFARVRTTEGLPRIVKDRLLDSIAFTSTRVLQTLHHLNSDGHIETRFGTLSEENRTRLARWLRDSLGHILLLHPKAAKLDFVNVLRSLPIWPAYRGSGVSVLKSLSTSHIRLLPQHAKPACSIVPFLLANPNLYFVEHSEDISCLEVIQPMSMGEFSRLLKFPPFFRTDDMIPRYKPLLDVVIKLGGQEIELSKSLRVPNGNLELITVCSMYKSNVPEFTAAFAHRRGEKFVHPQLSSYEQKLVVFGLRERLTFETFKECVAAIDQDFDEATQPGDLDRCGVIYEWYTTRLPFTVTNSDEWRQLDGYSFIPTRLSRREGVATLFNDTGFALRLPRIVSPRQILRPEYSAIAWTQRALFDGTPDKRLFMADESVGIPAIEEVVKHLHVLATKIAPRHSRDAGLLSDLKGTYKYLQERHGEAARFLLSHRNHARLFLNVDDPETESWEFLPASQIMFNVPDEDDRKEARAFLRPFRELLLASGANEIKIPSAAPIAPSSPEAHLSRFRASFDMQRRTKVLTDVVFRVAGATAAEEDRNHWAHRALLATASRHFYDSFCAQSGFSESRAASVEEPVVIELEDDLEFRCVGLVLDHIYTGQFQESQGRECLLELMRLAHRWELADVQAKAEALLVPTITPGNYHELREHAEEISATGLLEKIEEFERENAFVLGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFX6</accession>
    <name>A0A2G8SFX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFX6"/>
    <dbReference type="OrthoDB" id="2755887at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="296"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="805" mass="90685" checksum="C19B5BC2A654C05B" modified="2018-01-31" version="1">MAHSTVVLDCDEFARAFLPQSVTMYNPANSSRHQFSPLEHADASSGREISELVIQAFNDDRLAAGSKISYFRPYLAAVSSTSITNAAIFDAEHALTRTQPSWVEQRVPILFCRHFVGSDPFDTASYDDECGEIKMERSKVFDHLNAVVELLFAAQHRVFLFFLVVIGRRFRLLRWDRAGIITTPSIDYYEQPDVLCDCIWRLSHLDDVALGFDPSATRVLPGNVDYVTMDFAALQNPNDADHAERALRDDESTDPTTFEYARTLFRNSLASDWPRFKVQIPSRTTYHNFLIGRPTFHASGVFGRGTRGYVALDCNTGRFVWLKDAWRTSHILSGTEGDILQKLNDTGIQNIPTLLCHGDVHDQHTVTGEWWECAQSLSSLPSPPCTSSSPPSSCTLTGSTSPSSRKRKRVDDGADEPTLHSQCDIPLRQHKHYRIVIAEVALPLDHFRNGKQLASIVLDAMEAHYQAATNPTTLILHRDISGGNILIYPRVERNKDGVHTMVWGGILSDWELSKPVDDEYTPSKATQAEQVGTYQFMSVNLLSHPSKPVKISDELESFFHVLVYYSIRYLRSNCAHPMSYIDNYFNNYAGPGRLHTCGWKSLAIEVDEWLSTRFPHRPLLFQSPMDDILGSLLSCFQVHYKVMKDDFAKTGPPLPEFEQPPPDPSGKGLAPIAVRKIIFFDEDDDDNDGHISDDSSDVDDDDDTPTPEERDRARQILDHTFVLDHVATIARSLDWPEDDRIPSSTARPSPPRTAAGDSDASLLPPSSHKRRRIAGPEPIVSLPARLHRSTRRTRMQPRTMPIRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG11</accession>
    <name>A0A2G8SG11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG11"/>
    <dbReference type="STRING" id="1077348.A0A2G8SG11"/>
    <dbReference type="OrthoDB" id="2596179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="150" mass="16646" checksum="4C27AB22795E667E" modified="2018-01-31" version="1">MGVLDYLPHLLYSTALTSIAMHHLHQRKAAADERSHVAAQISILEDLRARLSARESIPEREVERLWHLARSHDVWAARALAAAAAADPSGAGEGANVKSVHMQARPGEEIGWREVLLGRRFDSRRTEELDRKDLESVAREVQAGAGEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG96</accession>
    <name>A0A2G8SG96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG96"/>
    <dbReference type="STRING" id="1077348.A0A2G8SG96"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32638" checksum="0271301C2A6D3D46" modified="2018-01-31" version="1">MMYSTALWGDEEGGVRGDLTQGPTPNDLEAAQQRKIHHVLKTARVKPGDRLLEFGTGWGGLAIEAAASYGCEVDTLTLSVEQKELAEERVRERGLEGQVRVHLMDYRDIPPEFENAFDAFVSIEMLEHVGSKYYKKYFEVVDFALKPTAATIVVTCSTFPEGRYTNYQADDFMRRYMWPNSCLPSATVLIDAAYDASKGRFTLEGVENHAPHYPRTLRTWDRRLKANLRRETMVERYPALKDDATYFAFLRKWEYLFAYAGAGFAKGYITCHMLTFVRASDVTAACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHE0</accession>
    <name>A0A2G8SHE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHE0"/>
    <dbReference type="OrthoDB" id="2611509at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="14482" checksum="CD077CFE6DE05B21" modified="2018-01-31" version="1">MGRPKEPSGTLVAPEDLREHRASRDFLGPCCLCPALTGENTRTFVEAAMYDRGDGEFVAMCATDDCGYLVFLGRIFQRGNMPTVTYTKREDGTLEPPRVYHQSEDVANVFRGTHFYDMSCECNLGSPKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHE9</accession>
    <name>A0A2G8SHE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHE9"/>
    <dbReference type="OrthoDB" id="2751071at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="157" mass="18158" checksum="C8D4F47207304930" modified="2018-01-31" version="1">MTHIPTSVLPFPELADALPLEDVMALSRLAGAREARIWTRNRIEECKKQLDALIAIQNTITPINTLPNELLTKIFASIPIYSWLSAPWMLSMTQICRRWRAVVLATPEFWVKPLEYWADSYNGRELNHHLPVFLERSSPCPLQLYELERSSDKSYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHG9</accession>
    <name>A0A2G8SHG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHG9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHG9"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25003" checksum="5820A913DB3D13AC" modified="2018-01-31" version="1">MATYHDDIHVYYLVDLVKNERIPPARGKTGGIVLAGWSLGATWIIALLAHVAEFPVGDVRLGEYVRRLVLYDPSYLCFGYPYPTGTYHPLHDLASPVEERLDKFGVWVSSYFTHGDLLASGLKALADRNAAEDPPPTVATMSAEDLAESTSSAGAPGGCEDLFAQTCFAHGVYESLRKQAFFLRDVPAGGDDWRSVELRYIWCDRSIWEMPGESPFHGRSLIFQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHK2</accession>
    <name>A0A2G8SHK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHK2"/>
    <dbReference type="OrthoDB" id="2757618at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013721941" description="F-box domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64838" checksum="FCB980840D118BBA" modified="2018-01-31" version="1">MAVWTASLVPLLPLDVLHLVGAVAQPPDLCSMLQVNKALNRTLTPILYSSIELDAWDPILVCMKTLGSPPNERSFGRTLEKHVRSLIIKRPITRKPFYASGGIGEILLKALPLMVNLKHFSSGVSLSPCSSNIFYLLATGSCPSLQSMELQVLGEIPTALEEKDPDEIESLTLQAPRNLQRLALELPVGSTAQRSFVQQLLRTWAPTLRSLSLTIDGRYVRGIWDHFLPPDVDFVHLQDLATDFQALSHPPFRRAANVRSLKVLRWGSGELSSGVLPDLHTLSCPAKQLSAFLPAEADHPRPIATVSLGKASYRSAADDTSWPTAQDPSVWRHVFAALRHLRYSAVPVTSLTVDVASIPIAGIQAAQPYLTALEYLDIVLHRAHTPDYMDMLADELVTRLPRLRTLLISHAPPTRTHGLSLDDTGLSFTESMRLSRKVILGLEDKQSMLQRLAVSADIEWRKMDDGWRWSGDPRYYRALGGSLDDPECKDELEPEFEDEDDEVTEAEGGSVYSGPSEDGTVCADSGYEDGKGVESDGYEDGGEGVDDGQEEDRGSGDDGYRSEASEDLEDTRFLPDVVSVWEELPYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHZ3</accession>
    <name>A0A2G8SHZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHZ3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="102" mass="11515" checksum="CC3D1006FDCA3B40" modified="2018-01-31" version="1">MPGRGNRDSMLVPTNTLCSAEAYATLKGNGPDGKPNGRQLIVKKNIKKCFYIVKAKYLTYSVDKDICNMKKEFSNFRALTPEELAQYSRSLVPPPGRFINWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHZ4</accession>
    <name>A0A2G8SHZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHZ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHZ4"/>
    <dbReference type="OrthoDB" id="2722301at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="51"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="363" mass="41610" checksum="B4E05A5AEF497F5A" modified="2018-01-31" version="1">MEELLFTEDARAYPTIPDAIPCAVDRMDSLSVDEMLGLWFTAKEWLLLRGVRLYGLEPPPGWGKTRIARGQDMVGRDIILKVIQKDSPQHHIFQTLLQHQSLFTDPRTFPGVLPPIDIIETPHKYSIVTMPLWGTYPCLTEMEDVRQVLTFIRCLLEGLSFLHANRIAHRDICDSNMVVSCYRPDRDQKRFGGDLRELRRGTDIRYAFMDYDQSIQLPLDVSVKHCRRPSREAWMGCDMYKPLDVSLGESQYNPFAFDVAMLGNMFRAYLSEAIPTLPALAALFDGMTTHVVSRRFSADEALDFFKSNIQLLPQEVLVAPVTLEFDYEMMYHPERLDPQHNIMLGLQDTFNGTVDRELEGTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ92</accession>
    <name>A0A2G8SJ92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ92"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="734" mass="76500" checksum="979A8298284209E0" modified="2018-01-31" version="1">MHGPRGEPPSSMFYGQHPQFNIPPYGGDPFGQPMFPVAYNPYPSGPSPIFGPPGAVQTPAMLGEGLGAPLEYPGMPGMPGMPGMPGMPGMPGMPGMPGMSGIPNSTPAVQVRGSRRQIPKKTNAGRDASVQPRVTDKLGPYARHRKPLKAQKPSRDSDGTPEAQVSDSSPDVLLGVVEPAVMQAEPVADPVAASGTSMHASSERTSTEPTLSTTPPFPPTTLVDQGTFEVTNTPIPAFVPVPALDLGSSTATAQNNLSPVLSFDAAGLSADHEPAANSSGQVDTQNSGDLSARTSNGHVTPPVGSVSVVEPTSNDANDAMVGSERSSSYYSLANPIEEAGGSPGDESVRTVLGREGAEAQGGSPHSTAMSIASGQDPMQLPEEVFSVDAANSVDAIPAAVHNECGCFTTIAALRGEVDRLQQTVNMLMPAAAGPAARQADAHEACIVTIHIPGSSELGEERQQGFADRKEGGFVGLCLFDVRRRPPPILESSLESTTLVAPTDSPPSTHRHAFASEVDGRPAAWREDVCIPRSTCAKHRGAREPGMRSGVGQGLSPSVYLGPGSAGDGCSAPPRLNDSYWSALGCIVAVAEWLVSCALPSSRTDHVCCKCVDRQALSGRARNRGTTSTTPELTRRRLNYELVSSYARGRPLSFQSQNLIRSPAVMARDEVTACDRLGHAIEDLEGAARLCLAVAPWPVPSPAGGLASPSGSPSTDDHPSRSKGKRFSTCHLHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKV3</accession>
    <name>A0A2G8SKV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKV3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKV3"/>
    <dbReference type="OrthoDB" id="3364141at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="366" mass="39602" checksum="BBD97F5063F73109" modified="2018-01-31" version="1">MLTSAAWANPHQLHPWFRMPSQKRKDLSDDDDSPRTAYHEPRHSLSPPLRSPKRRRCDVLESGMSQLTLEGLPYVAPSMHRGPVGDTSFGAGTSSSYVASTTQVLSPSAFPSTSSQPCADGPPSPFVTHIPVKPATPVVLPGSVEEPASPEAAVAGDSDVADVSMKGPSWYEIEKDRTFDSPVPLPSSPPESFHASTATRAPSAVYLSPPLQRTYPHCPPRSTVVDVPHEKTGIVITELEDSDAEDEETGAGADSPVPFKISSALLDRLPKSHALGPVAPDPSLARALVLYRPLVVRDEAEAEVRRREAERGRETGNEKQKEVLEGVVEEPQPIGEEEPMDEDTLPCTPMVESVEPGYEPMDIEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLQ0</accession>
    <name>A0A2G8SLQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLQ0"/>
    <dbReference type="OrthoDB" id="10467828at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013815956" description="Transporter" evidence="2">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11744" checksum="FBA849062883A9D3" modified="2018-01-31" version="1">MQFFAFPSRAIGVVFALLIAASTVSALPQPTGVMATGAAATLNHDENTMLKRHGEENTMLKRQENSMLKRQENTMLKRHGEENTMLKRYGEENTMLKRQESTMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM75</accession>
    <name>A0A2G8SM75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM75"/>
    <dbReference type="OrthoDB" id="2984821at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="212" mass="22997" checksum="D79DF48E29A5E28A" modified="2018-01-31" version="1">MHSNSNIDCAIAFVIERGQQLSVPNVFSAYLQTLISPTSYSYDGDRFETDDAIARAALVTFERAMDKYPMPAPPAKTKTKTSKSTSRASAPADAAKTGVGVAPLAGRSRAKKYSAEVAELRWEYQQAVLRATADGEYQGCSCMSCASLSSMRDRLPVSASEGEGEGEEGEEGDQMVEPVRVRRRRKAKKQARKKARAMPFDPYAPSTSAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMC8</accession>
    <name>A0A2G8SMC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02686</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMC8"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17730" checksum="026E8255CF86D96A" modified="2018-01-31" version="1">MSEPYPTVWFSTSTGVGRAVTEVTLEKGDIVVATARQPNSLDDLSLRYTTDRLLILPLDVTQPDQIAAAFAEAERNARSGASTSSSTTQGSEPEPHVRRFGRDKATPWKDAAQTAEAICKIACVPDPPLHFVLGKDAIGMARKKVAELVADIDTYEPVSESLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMU4</accession>
    <name>A0A2G8SMU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02885</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMU4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMU4"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013688188" description="SUN domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="122"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="641"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="774"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="854"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="903" mass="98455" checksum="3337B5B4C673503C" modified="2018-01-31" version="1">MFSLLPTSLLALLYASPAFAAPTTPNDAFRALALVAPKAPEEPICCLRPLPPLEPPAEEDVLLSFEDWKAKRFSEHDIPNAVHKPPENLSESSGTTPPDPSHPSPQTQTQQPVQADVQEPGGGPPPPERLAPQMRIPITDRFNYASLDCSARVHAAHKTAKSASSVLSSKKDRYMLSPCAEERQFVIVELCEDIRIDTVQLANYEFFSGVFKDFSVSVAKQYTNDPKEWVHAGTYRAKNVRGVQSFHPPPTLRDFYRIIRIDFHSHYGSEYYCPLSLLRVYGLTQLEEWQWETWEAESRAKRSVEEASSSIEVPAEPPKPAPTPPSDSLSPGNASIPPSPITIAGNDSSTVGTPSATTGSIPTAVDIPHSHQSIFTSSSFTVDSPSYPPSDSLPPKTETQEVPYDSSRHRSDPVYYTPVSLSSPSPSSHAHSTASDNHSSSIFIDLTQSGSSSSSSSYSASPSSRGSAAAPDASALSTLSPSYLPPSPPVSTGGESIYRTIMNRLTALEANTTLYARYVEEQTTGMREVLRRLTEDLGRLEGIGKAQAQLYHRSVVELEKQTQRLEAEQRLLLHRVNYLTDEVILEKRLGIAQLCLLLIVLVFMALTRGSRGEYVPPPEARMSVRDWGRRTLSFSGELVNRFRARSSTPPRTASNKNAGENEIAFPTFDLRPLDEPSRSRRSHHPIAGSSRRNGARPHTPTVRTPVSRHFVHSRSGSVLPLSPASLHALRPGIQRSNSGGFGSIGPVPRSAKRWARSAHLHEVKNVASPRRLDRDLDLDVDEDREATPMPRVSSSAADDETDAPVLLVPPELERSETAGKGKGRMFAASPMVRQPSPLRDMDAIDLASPPLRAMSLSGSAGETSEWVDTDVSGSECDSVGDGGGLDSAGLRERTFVRPTNSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN57</accession>
    <name>A0A2G8SN57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Aurora kinase</fullName>
            <ecNumber evidence="1 15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_02981</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1 15"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN57"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN57"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072479">
        <property type="term" value="P:response to mitotic cell cycle spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="150"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="278"/>
            <end position="279"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="12">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL35191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="416" mass="46694" checksum="FA5BB4DFC9E08D51" modified="2018-01-31" version="1">MTSSVNQLTRQISALEISSKPNTTRPATTQHQKKPSQTNVSKLLSKYAAPNPIQGNAPGTLQKASSTNSIASKSSTNTSRSASPTRSAAPAVPSAKPITATIDIGSYDGGFEIENETRGHAVTGAAAEELALDSSVAFERPTREWHLTDFDIGRPLGKGKFGRVYMVRTKAEPNYILALKCLYKSEIVQSRVEKQIRREIEIQQNLRHPHVLRLYGYFHDEKRIFLMLEFAGRGELYRQLTKYGCFTEKRSARYIDQMADALIYLHGKHVIHRDIKPENLLLGINGELKIADFGWSVHAPGNRRKTLCGTLDYLPPEMVEGRDHSEKVDYWALGVLTYEFICGSPPFEDLSGYNATYKRIQRVDLKIPSKVSPEARDLITKLLQYDAERRLPLVEVRKHPWIVKYRSKGHSTAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SND7</accession>
    <name>A0A2G8SND7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SND7"/>
    <dbReference type="OrthoDB" id="2762700at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="401"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="619"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1289" mass="144654" checksum="AE7383FF5E4F9500" modified="2018-01-31" version="1">MQRLEQIRLSMVADGPLDVLQRIGNPKRLALASFVYDDEYADGGHSIPSLLTPLAVFPNLHTLMLWEFKPWPLDDALVFPPLPAVRYLLLSWASLYATGIVEHCPNLSTLVFSGDFDFTDEAESVNSRWRPLRRVMLAEPRDGVCVVDRLGTVHLFQLSGGLDVAAEIVDSFFLRLLRLASPIGLYFCLRVYRCEWALPSPFWKDFPAAVPTLRSLELKLDWSIPWSGQDYDQLLRQLLDTLGKIPLLVLKILVPPTSVPRRVKFRGRRTNAAAYKELAEAKMRREKERVQAVAEWPQPFADAIPSLRYFSLGDMAANPALVDDANASETSDEADTDDAENSATPEHWKWDALRETGLMKRMWWKIVEEGGRRVMVEISADEGERVKRQFVWVNNPEQERYAILSHVWSRDPDAPEQTYHDILKIQDEVRVARAADPTIPVDEVLRRASPKIRNACRYALSDGLSLIWIDAPCIDKTSSAELSEAINSMYEWYRLSTVCYAFLHDVTEDPYTKPSSFRHSAWHTRGWTLQELIAPAIVVFLSSDWRMLGGKHRLADVLEDATGIDRGILTHSRPLSTVCVARRMFWASKRCTTRKEDEAYCLMGIFGVHIPIIYGEGPKAFIRLQEEILKHIPDQSIFIWYRADPMELPHSDDSSLESRSSSSIPSPRPVTIVPPPISPPPEETLDCTSHDHDALFASSPARFALSSGIRTIPKDVLARRLGIHELPPTTYIVTSEGMRVTFPLCSIAPAVDVAVLACEDQRGNLLGLVLRQTKLAYVRSVGAPLNNVSFLDNSSSIITQHPSVYIRPIPLVDLLPRPLKSPSIFGSIFSASWVRAREAQPAVAEVYVVHYRTPSMPPRPSLTLEDSQGDVWPFKMIVSRHLSAGYVGDSYTCVFSEREPSPVLDIFTRPPSAIEASSLRLMTNTPSYTLRITGEAEWTFVAGFTRSECRLGGTEAWSSLAVKVTCIREGEVVHGTDYPQHDDFPGPGDSCIGHVHRWSGSNRFRYKYFNYPSTNAWGPLLIQLCIYLEHPGSHTYPPTVSLSADVTAPRKLPLSSVSSLTASSEIHFLISELGTPRPLILLPSPQPYIPSGDSMPIWESRRATWHSSLWRHLRSLIRYGKGGFHGRIPRMGDYPTRPQTPMPTSKFGHIKLRDALDQKFPNLAHANRPAFEDEEQQEAPTSLTIRISIMDRVPYIRAVNIMGLIEPGQPLSKGMLATAIALEVHLFLERERGYGNPLQYGEREIQLKDLVLVDVERESSAMLVPMLALSIDDAPVSAKADNLSPAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNE4</accession>
    <name>A0A2G8SNE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNE4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="14116" checksum="AA3BD46B59B453FA" modified="2018-01-31" version="1">MQPYLSVNRVRNMVVTGDHSRSFYNPIPPYTVALKLVQTPLELEGAARNAFDGSLALSHPSHIVPSSGSSEKELIVNRTSARGQASILGTSSFDQLVPSASPPLSVTAFELQAYQHPGRILHHYVLFSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP66</accession>
    <name>A0A2G8SP66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP66"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP66"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="1">
        <location>
            <begin position="82"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="498" mass="54814" checksum="235517C9C71900C8" modified="2018-01-31" version="1">MFFSAQWHPLGSKQTLAPRIAEITGIDIDILVHAKPLDEVSASRRISWAAERQTTRPEDEAYSLIGLLGVKMLISYGEDHAAFFRLQEEIARQLRDPSVFVWGPILPYHSLLSGSAVSTPSIISSIPTPSQPRLLAESPRDFLYSSRISRLSSDVFLRRLGEELQGFRVFTQTAFGFYARLPVLPLPSQDPYAFIAVLPCDDDDERAVGILLRSSAELSDANIFYVLAAAVGTHPAAHITTLPKETIDSLRPMLRMADVYVTHRLPVRSQEYADARLRAALCHGRGSFEVRQTLWSRNALLWRGYEVSPASYVNVALPTLKYHEELFRVSGAASPGPGVIISRSGERISIQIGRCGCSFGARLGLLAVSASFQSLVALPQDLVNGPDGESLLHPFDHPAHISWDFVRSETATKDLPLDPETMLRLTLFMGSSSSPTKVLHLGAELIDVGDMRLGERAMTAAGGMEELERSRFGYEKALHLASWIQQVFGFVGGVKDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP72</accession>
    <name>A0A2G8SP72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_02287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP72"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP72"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013970382" description="Glycoside hydrolase family 5 domain-containing protein" evidence="6">
        <location>
            <begin position="23"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="120"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL35559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="466" mass="51877" checksum="10B1B22C0D2A7BD2" modified="2018-01-31" version="1">MLRPSEVLRWLLIIFLFARGHARQQCRLIQKLDVQSGGDHSQLPLSANPTASSQPSQTASATPSVTPFNYGQDVIRGVNLGGWFVLEPWITPSIFETTNNSNIIDEYTFGQMQDSNVASNVLQNHWNTWITEDDFVAIKAAGLNHVRMQIGYWSIPITSADTNYSTSVTPYISGAWPYLLRALSWAKEHGIHVILDLHGAPGSQNGYDNSGRRGSASWAQGDNVARTLDLVRFMAAKIGGMIDVLELLNEPGGFQSDIANVIPQFWKDGYDAVREAAGSSLKVMIGDAFLGVDNWDGFLAYPEAQGVLMDFHEYQIFNYDQIELSQDQHINYSCQVLDTLSNYAKSNLYTVSGEWSNAITDCAKWLNGRGVGARWDGTYQSNQPTLGSCDGYTGNMSTFSDDYKTFLRRYFESQVAIGEAVQGWIFWTWKAENADDWSYQKGLEGGWIPQNPIDRLYPNICAASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP79</accession>
    <name>A0A2G8SP79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP79"/>
    <dbReference type="OrthoDB" id="242766at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013869959" description="DUF155 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="168"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="431" mass="48118" checksum="CFD77DCFE31D9564" modified="2018-01-31" version="1">MRVKLLGVLADAGLAATLAHSRPPSPIATLGTMNSLAHVHRQLRHTIPTTPRCWQWRHSPVAANAALRPIQSFRRTFTERRSSPPEEAPKPKPKASTALRRAASASLPIRSNPTPTRSDIHPIFTYATAERYLMPNLRSALPKDARLLHDAWWVPRWTDETSGREGEVFVFGNGSFVSWGLGEDEVGRFVEQVIARSAAEVARLKELETEDLEFVTDPQEDTRLQGDLIILGRTPPLSNEDSLPIDLPSSSYPRETLLARYAFSQALSRSTALSGLETSLEHYLSSVSLLPQALQKTGKPGLGRRALVMKLGELLRFRQGLNLNRENFSDTPDFYWSEPVLEGYFNSLSNALDMRTRIRSVNDKITYAAEMQSVLRELLTETSAHRMELIIIALIAVEVVICLIRDGPELWHMVFGTDEKADDSAANEVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPG6</accession>
    <name>A0A2G8SPG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPG6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="13691" checksum="892D488C9C234DC3" modified="2018-01-31" version="1">MRKGFSSIDLLGEIVIEAASRARRSRVPSTARPGSRLSITFAFGAVHRMTLAPPSFLSAAAWSTFEPSMYSWAPSWWESSLFDSLEDSATTRKPIPRATWRARWPRPLIKELASEVAYMGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPR4</accession>
    <name>A0A2G8SPR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_02462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPR4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPR4"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="15195" checksum="98200ADA4FA23044" modified="2018-01-31" version="1">MSNKGRSTPRVVCCAIPIARSAGKVLVITSRKRPNHWVLPKGGWEPSDGVLEAAASREALEEAGVRGKITRFVTTIPSASSTYHFYELDVADLDTEWLESKERRREWVDYAEAVRRLSWKAELAQGLSLSTLAPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPY2</accession>
    <name>A0A2G8SPY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GET1</name>
        <name evidence="11" type="ORF">GSI_01486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPY2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPY2"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="3"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL35826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="23810" checksum="230B907DF356A6CE" modified="2018-01-31" version="1">MALMAMLFALVFVTELISWIGQSVLLEFFYSLYLRIFYGSAVARQKQLRSEILLNKKELLQTSAQDQFAKWAKLRRSVDKGLSDLEKLNSELATARTAFSLKFNSALWVMTTGLQFAIGWWFRKAAVFYLPPGWFGPLTWWLALPFAPAGSVSCGVWQMACRRVIKVGERVVREVASSGASASSGASDGATSGSASERERKATEAQDVGKKSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQZ5</accession>
    <name>A0A2G8SQZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQZ5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013694848" description="Transporter" evidence="2">
        <location>
            <begin position="25"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47442" checksum="2AD172A36ABC6A59" modified="2018-01-31" version="1">MATSFSRRLVHVLVPLLLLRRGRPLQLRLLPLHLPTPSSVFHLQSNRQGVGRVVYRAARPYQILGPGAVPLLWILSSSRAPMVPDMAMRVGRHLTWATMPRPRWMWSPKARYPHRFLRPPSRTRPCRLPRRRRMVPRIGPSKCRCFWTFRRLPCRLSATILGLGSQVHSPTHLRIRQTPVVPLVRSTRILPTSMPRTPLIRSIWRLPRQLSGRRSRRSTLLVRSRFLIRYHRLRRFFLILACSRMGLDSYIPVSLVPCGERGERKSTLFYWFGFLSFSHLSYPNGLPAVSLLPLFSSATYCHSLPSVVSSSGGLASWIALCRCRWLVILLSVTAFSVLLSTTTFVFVVPAVVHVVPPLCLYHVQFSSLTLYSHSLYIDMAFSLYAPYLVVCALTSSIVLGVWAFPVGSYGGSRARAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRZ5</accession>
    <name>A0A2G8SRZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRZ5"/>
    <dbReference type="OrthoDB" id="10638066at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="434" mass="45509" checksum="F5A34B47A0B8C30E" modified="2018-01-31" version="1">MAPFFWTENKTRSLEPSSAAADSMATQAVALFCASVLIFLVFLGSSIVLIRRRRLRHRTQDTTAEVEAQIVQLPAREPAASQPDSKEKGESVSPSRSSSSKSSAAVPLLPLATAPCSGLTATAEKPVEKLMARTSAALSKADKYTTLPLRRARQARQSKLAQKNPVLDFSTPLATLDAEIVNSEANSAAGRRSSESHQPSMRSTSLTVGTETPSRSELLLHSTAIAPSTCGQPEPALRPSPTVASMEVRPLEADAAALPDAKGMGMLVSGSLPSFSSAFSASSICQLADDGHAPPEADSLKEKEANKHSFASLDCETPRGRNPVLVLDAEKGTPSCSESTPSLSTVTTLTRRDSSFSSDADTVCELGPGKMSLITVTGKASKLCDPLSFPVAVSDLSLDISSDKGDDIVSSRPNSGTDDLGGLTKYSGDLTTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST33</accession>
    <name>A0A2G8ST33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spherulin 4-like cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST33"/>
    <dbReference type="OrthoDB" id="5342184at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="26799" checksum="C709A251B893F187" modified="2018-01-31" version="1">MHIAPAATSAAATLFSGVLIPLYINPVGGPGCSGWGSLLSTIAAHPTVPYYAVINPNSGPGGAGTQPGAEYQQCIPILRAASDSVVVLGYVPSWEADSSKAAGVISDVNTYAGWSSSYRVDGIFFDQVSGAASDFSAYTNYTSHARQTFDFIALNPGAAPADTDYYDLADILLTAENFYDQFSPSQLSLGSATPPSQQAIVLTDAPSTPPTALISKLITTDKVGAFWVTDDSQANGANPYDTLPADIETFVAAIVAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STU7</accession>
    <name>A0A2G8STU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8STU7"/>
    <dbReference type="OrthoDB" id="3363734at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="54903" checksum="38CB9B1B172FF1D5" modified="2018-01-31" version="1">MLASSRAHHTRQQPSISKPMPVSQVSPTMRPVSPPTSPSNKGKSRRPSVSSPMTWLSRASSSASIQSATPYAPSRPVRISEPRFANPVDALTAPRSGVLGAGATVVRTPQEALAGPRASASSPDLLSRVRSPTPVQEYDEETDTPGSPPLPPIPDNVSEYIDEDASQDTYVEDSETIASHPSPMSVTVHPPPPNRPPPSLPHTPDMHVDAAPMRSTSPLRPHKAHSPLDCFPAVPPLPAVAIQTPPQAPFSAILVSIAPSTLDASKIIVSLETSTATHKAMMSTLTSRPSHFTSYLLGLLPSSDSDAQSVYSTTSDVDGSFNSIFHHHLATSGVLQASTNLHIFLDRPSAPYTHVLAYLRSLPSPEHPATLPHAVRLNGSPGRLEALLELRDEASYLGLEELHALCVDELRHRQPCPNLGGLGLHMRGFSNASTKSLHTLRETSEPVDPGQRHSGHSVDSGFGSNGAGPRKSGASGDSLDAPWPSPPSLKQRLVHKEGGPKKDGNATSKARPTGTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU55</accession>
    <name>A0A2G8SU55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU55"/>
    <dbReference type="OrthoDB" id="3366139at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="338"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="472"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="552" mass="59483" checksum="281FE05E9CDF88B7" modified="2018-01-31" version="1">MSLGAYTGFTTNINVDDLKRLCWVWEWDGKTLPSEAATSAGKDKAKEDAEENPFLDDAKPAAQAPPKDWTRGAMGIVISQATHRQKSTASRVPVYGIGIEVEMDIDKDMKGGMAAVARWTGEKETRRKAVMTKLRQWVKVATHLSSFKLHEKEDPVPPIPTADLPSLPPTQKPSNLTRLLASSSPKSPSASSILAAPQPPGSPTRSTSRSPSKSPSKKDRDFAVPFPATPSSRLGTPTTNRIFKTPSADRIFKTPTTDRIFKTPSTNRILFPKTPSSRHSAASDGDPSTPTSARTPSLSGRDTPTDSDKSVPSTPVHQRGPDASTVPQTPTSSRRQALYERVRQRSLQNTPTKANPTGASLSKDELFRLGQEEMRRRLLLGRLSGIAESVWMYFSNPAGGATAVPTARKRRALPAAEVAAAVVKSSPVPLSIAETQESLGMLTKMCPFFLRELNVSGEEWLEMPEPAEPEGDAAASSSSSGAGAGANASASPRKGGKGKAPGLVPKSPSKFKTKDESVADFFTRSPRQVWAQGGGLREVRERIRRELESIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUA7</accession>
    <name>A0A2G8SUA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUA7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUA7"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="236"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="948" mass="103406" checksum="AF89123FEF5DF7C2" modified="2018-01-31" version="1">MNVAGPSQSTPIKPLSSSTKSRLRSTQILTSLPQVVSELIQNSLDSGARNIEVSIDPGDWECWVRDDGSGISRDGLALLARGPETGRYGTSKAYDTMSLDEVNTFGFRGEALASIANLCCLEISSRTTHSAQSWSVIMKGEQTLYSGPSIRWRRESPGTVVSVRDAFYNLPIRRKAHPNPPRIIELVRRDISAYALVFPGVSFTLDTMQRAKDSAQNKPNARLLTVSKTSSTLFAFRHLYGKALATHVEEVSERHDQMSLEGFLSLHGVYSKAYQFLYINRHPLETCGLHRTVEGVFARSSFSKHAYDEEGTMDTIHPSRRRSPRKTEKKPVYVLNLTISPRFVDNTVEPAKTAVQLQNSAAAAAFLSSVVEAVLVRHGFLSRRSQKADRHDGTPPPRKIRKSTHAGGPDPSGLLAGLSLNRSSSQGQGGLVPTDTSGPGQCGSAPPGRTTFLLPAIQEEEALIVGEAEEATDILWKDPATGETFVVDARTGNSYPQNAPAGSSTQDASGTPVPRLRRSLGERDSARTGTVPAWMAEALQANEAYRIVEQKIPVLPSSADFVQRFASHSCNQGSGAHRHAGPQQQTFHPWDAPNFGRFSKDDLRQALVLGQVDRKFIACVMHPTVDDEGIRSEPMNEYRSNESQQNNIGSGVCTRKLDPPVNILLTRPEAERIGGSSDVRGAFSRWGVSFALPSGPIRALDGGADYASYIQVAVNTVPEVVAEKLLAGDELRTLVKGFLARLESNGVPDVLCPHGDGSDVLTWQKALRWCPQELVELVNSKACRGAIMFNDTLTLEQCKALVAKLSDTDMPFQCAHGRPSLVPLVNTRGATKNFGASHAHVNWSGFIPSQIPPGWESTRYMRILSSSISRILHLDFLLHVLIPPPMAHADHLAPLPHPGSRIDAAKPTQCVLYVRIWFQLLVGICAYRNMTRSASAYVAGAWVAGVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUG2</accession>
    <name>A0A2G8SUG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUG2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUG2"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08570">
        <property type="entry name" value="GDPD_YPL206cp_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="11"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="327" mass="37395" checksum="9A11E76DEB7DD339" modified="2018-01-31" version="1">MTMSESTRTLPECWGHRGASAAFPENTLASFERAIHDGAEGIESDVHVSLDDVVIMFHDPTLDRTTNGKGKIKEQNWYGPDGMEQLRTSKEPKQSIPTFAETVALLMKPENHHVTFDIDVKVFNEPLHLFTLMHEIISVQPNWEIDLAPRILLGLWHPRFIPHAKTILPYCKRSYIGVSIPWARRYFWDSCEVFSINFSILATWEGQRFREECKRVGKKVAVWTVNEPVQMLEAVRWGVDVILTDKTGDWLALRESLRGDYDGVMKGHSSTFLWTSPRYYFPTRMFWETLAHYYLTKFGGPCRTLDVHEDSPASIAVPHAAAGTVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUH9</accession>
    <name>A0A2G8SUH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_01066</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUH9"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="16"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL37373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="117" mass="13553" checksum="827731204D810073" modified="2018-01-31" version="1">MSSLPSPFTAAHRTYVKNLYRRILQNELDWIVQRDLWRARALSIRAEFERNRDIHDPRALAQIFAKAEAGLAARKHPDPYRPPEAPEGTKWERNLPPPVGPIFEHEPYNEAHGRAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLE1</accession>
    <name>A0A2G8RLE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_15020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLE1"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL22332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="19789" checksum="31E3CACA1C3F0A49" modified="2018-01-31" version="1">MSLLRACQQAVSKQTIARSALVAARPYTTPSADHTIPQAPPKLDTEIAEAPARDVITADVVSGAPKELRHRAVRIFQPTRSTTQSGSGKSNQWRIDWDILQGGGRWENPLMGWASSADYMQGTRLSFRTKEDAIHFAEKQGWDYYVAPTEVTRIPPKNYSENFVYKPNKLRICRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM13</accession>
    <name>A0A2G8RM13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_15036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM13"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM13"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="12290" checksum="B1464C013F8C5BCA" modified="2018-01-31" version="1">MAAVAPSRLAALSRLRCEIFQTAYNPTSVRTGAKYLRARLRGPSMINYYPEQLTVPRFNHMAGNFKIQHWDEYQRLADVEEKKRRGKGVPKKAKSPAESRRQSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM49</accession>
    <name>A0A2G8RM49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM49"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM49"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="93"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="405" mass="44125" checksum="A834B62C24C566ED" modified="2018-01-31" version="1">MFRAGLNTLHSRASPVFTKPFRAGVAAANLSSTSSRPATTTDWVATRKNHSHGPGSTGTLEDCDSLPTAEDFRISADAERAHALATANGHLGRSYLYVPATAEKMLEKSLTTSSDVIIYDLEDSVPPSPADKHGARSRLAHFLSTRSGSLPSPDRIAIRLNSNATEFFAEDIIQALRLPWIRTFVLPKIHSAQDLHHVSEEIHIAYRAHKVRNPNGPPIQLVASIESAKAMYNLGEIASWQSLWGPAQGGKLSALLFAAEDYCADTGIIRTTTRQELLYTRSHIVVTAKAFGLGAIDMVCVNYKDLEYLRDECEDGRRLGFTGKQAIHPNQVDVIQSTFVPSDKEILRAARILKQMEKAHLANRGAAGLELEGGGMEMIDAPMIKQAERIVKIATAAGLTIPDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN73</accession>
    <name>A0A2G8RN73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN73"/>
    <dbReference type="OrthoDB" id="3238347at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="205" mass="21320" checksum="2F27E576983874FB" modified="2018-01-31" version="1">MGRSAKFHKRQATLPCSYIYVSNNPHNRQDKKKTSSAGSGSGSTPAAQQPPSAAHLKPKPKPKTATAAGAPTPKEQKKRAGLKDKAKASASARRRDGDGPVLGGADYVELMLGGRRRAAAEAAKLPQDPDALFSDGKLILTVLVLGRPGLLRRHSPLGTCARSSLVALGDTAEQGLSVLSSLVPGGVNSSPSGRDVLPQSQWSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPF7</accession>
    <name>A0A2G8RPF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_14716</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPF7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPF7"/>
    <dbReference type="OrthoDB" id="2757115at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="335"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="42505" checksum="E8350DD07B0A667A" modified="2018-01-31" version="1">MDCTSFYTYGTETLSSSFKDWVGVPGSPSASHQARMDLDDEPATISSFDQDIDDALGLPFDVFGPLDVSYQPDLEIDWQSLFNTTMPFPPAAFTDDSYSTSDSFNQPLSPVSDTTLVDSAFPPFQPDFKLPPAGDVLVDQPVASLCSAFDDFQFTFRCESAATIPPLDFSPPQLEQHYYQDNYGCRQGQYWPGQQPSQHEVGAAGAVVPGLATGVEVNADAFAFTAMGPTLLPPLPAASPEPQQIDSPINTNKNALPARAVPKKKQPRVDSDADSNYSASESSSGDDTPAPPRKRRKQDTTKRYRCLHPECDAAFSRTYNLRVHINSVHEKKRSFACEEDGCMRAFSRKHDLVRHHQSAHTDLGSPRNANNAKGAKGGEARKKDKLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPR1</accession>
    <name>A0A2G8RPR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14639</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPR1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPR1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="24466" checksum="84622A546AB4AC6E" modified="2018-01-31" version="1">MPAPHTFTRRAVGYYVCAVAVVMCALWFNHRVYHIIRASARDPSLQEWREEDFSYVADDYPPTLLPPHQHPRSVALITEETVHYWPQTPHDWESMAPAGSGGFVRLGPQKQLFAVAMYHQLHCLRRLQQATTSSNGPGLDGTGEVHRRCLNYLRQMLLCAANVRLEPLTEDRASGDLKTDGIGLEHRCRDWTVVRRKVQANFERWTSESERMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPT2</accession>
    <name>A0A2G8RPT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14813</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPT2"/>
    <dbReference type="OrthoDB" id="3261349at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="436" mass="48355" checksum="1404815212B160B7" modified="2018-01-31" version="1">MVDHDVHGLSSSDVERSSRIAPPPFTTASPNDLLAFSGNGVDQHSAAEYDSDGQASNCDRESGSLFASTPLNSNTFPERYKAPNASRKPTHATCLLSPPPCAGNPSRYLMGLYPTNDGLRILSIITLNISPSYHGLAGILYYDYTLTFGMEVDRFWKRRASFASFVFYFNRYLVFLGHIPVLYEFYGTRDQNAGDSPFPYDRELMNIWSWRCSKVQMYHQLLAGIMQVVVAGLQMFRIHALYHGDRRITFALVALAMVCASVSIWSISRTWMQPSDQKHVVGIPGVGCDLMMTKIQGKYLSFAWLSILAYDTAVFGLTLYRALGVESRWRGDILSILLRDGAFYFAVLLVCHLCNIITCVLAPAVTRGVSVTITNVIASSLITRLMLNLRDPHLLQSRYGDSRASELERSELPWRPRTNAAACSSAGGSESSTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ43</accession>
    <name>A0A2G8RQ43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ43"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ43"/>
    <dbReference type="OrthoDB" id="3181259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="509" mass="57443" checksum="D4DE968DC26637B8" modified="2018-01-31" version="1">MRLDQPLQTLLTMSSSPSFEDLASWDDLNIILPDVSLEDPDDPRRLDPRKLPAEIVQLDQSIADLEDKLSALKLRRANLLDRRALITRLPPELLSRIFELGVHETGDLLFTLSLVSRHWRNLVLATPTLWTYIILDNDWSWRIPSFLRRLRAYLDRSQASKLFVDIDFRYVDSTHDTETIMSQLAPHLWRCYSFNVSVPDWFRMRKVQEHASCLGPALEDLYLRVDSSDSEYQDPFTVLSQPCPRLGYVMLEHAPLDCLGVPMPSLRQLYLLRDARCHSSARIAYPFKELMTILTASPIKWFSLRLALFTIDTTEDVFRATPTPQELPHLKGLSFDIVDPGSISLFLESTSLPALELLSVNAGEELQWLTQMSLTPSRFPALRLLDLRNCSFTGPALVPLVRALHQLPQITGLGISTPAAGLIGTRIFDMLAAGPDTIGEWLLPRLEAISVQNCGDISGHELLRVVSARRGAAAPQVANIAFLKITQCYSLDPEVLDRLTSLVETVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ61</accession>
    <name>A0A2G8RQ61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ61"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="104" mass="11205" checksum="70431697AE7F8367" modified="2018-01-31" version="1">MILPIHPPLPPTQISPSLLPSLPLLLLSFRPLHTPPTSIQPHPCITGVFSVPPTFIILDPFPPSCPPSTASPAIQAAITTIHPRCAWSLSTLPNTPHSHCHILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQD5</accession>
    <name>A0A2G8RQD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQD5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQD5"/>
    <dbReference type="OrthoDB" id="449091at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050955">
        <property type="entry name" value="Plant_Biomass_Hydrol_Est"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037:SF4">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43037">
        <property type="entry name" value="UNNAMED PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="440"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="934" mass="101394" checksum="CB4E66F538FC61B1" modified="2018-01-31" version="1">MLIVTHCFTSCRSVFFGLIGLSVARLTTTLQTQRQVAMNVPMVTESDGWTVYLSREWEVLGPFPIHAREQHFLSPSFPLNLSEPIDLDRTWPSSYVDGGSVGWSKACAGKDGLIEVSYPAVRWASLRATEGWAALQHHSVLRSTLIVHPPSRSHSLSEPQLLVNLFQGSFFTILPSPDAVGEAVIPEWHAGNIYALGKAPPNALKLPHPPSLDSPTTYQIVVSGDYEIRLFGDPRSILGTEVPKLSVTLAVDVQDSASTVIRDESHDVVGDFVGGWAFGNAVGIGLRSLGSWWTVTGATVSTGISENLTVSLLEKQRIGPTQTRVIPVVLIQTSPVYLDELEIILRLESGDAESEVFVTIPLLHHPQWSADSVPAGGIKATFFYGTSMPSAFLVLPPEEPRNVPLPPILALHGAGVDIFHSDRFWIKALPRQQHSWLIAPAGRTEWGLDWHGSSTQDAWSAVEALCDILASREEWNRWSLAPKTKVLVMGHSNGGQGAWYVAARYPDRVVGVVPAAAYIKSQAYVPWVQSRSAHYVDPSLRAILDSSLTPDDNDLFLSNLAATPILAIHGGNDDNVPVWHTRALISTLKTWNPHANVTFREDSEERHWYPDVFKNDEVAAFVSSTLSGQDAGASIRTFTLTVAVPSDSGSLHGWSIYRLGIPGRLGRLTVNINPDGISVETSNIGAFSYRPESLPKDVKNAPFLVDGQRIELDEATWDQPNFSLALVQEKGVWTPHALFDVATTSLTGRISNLLSSTSPITIVVPNRLPSPESSAALRIAHNLNVYHKLDVGIIDADEADRAVRDGSLASGNLVVLSYGKLRGFAASLLSKSATPFGVDGTTLRLRSRSLTAPSTGVLFLHPHPTNPEALALVIYGTDVSGLERALRLFPIRTGVTVPDWIVVGSQADARGTGGVQSAGVWGNDWSWNEAMSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR29</accession>
    <name>A0A2G8RR29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13721</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR29"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR29"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF2">
        <property type="entry name" value="OS05G0199100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117070">
        <property type="entry name" value="LEA14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="303" mass="33218" checksum="A2CE42F397F9FD2F" modified="2018-01-31" version="1">MSYHDPYAHNQYAQQQYQDAPFNPYEVQQQHAHGGYTDGTGAQAYGGYDSRTKEETVRPASGGYDNDDVTLQPMGEKTPRNMRQWRKDYQGNLWTKGSRASCCGRFFCCTLMIFLLLLISVVLTIALYLRPPNVIVGSPTVDVNSFSINSSSVSIALPVDISVNNPNFFTVELYKLDAAVIYPINSTQVGSGHMTNIKFQDHTQTNFTFPVTIEYNAASDPNGAIITDLAKHCGIDPSVSASDISVTVNIKIGVKIMLVPFTTSLSQQASFKCPISSNDITEFENLLKSLGINLDSIAGLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSJ5</accession>
    <name>A0A2G8RSJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSJ5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="386" mass="41571" checksum="ECDBCC66623FC178" modified="2018-01-31" version="1">MCIAVGSTLIPPPPQVHRSVSWGRVATGRPARGAGAGGVWPRGWQTWLSELGVEKEGRIREGRGREEKGGNPRRRGKGGHRGPGEEETALPRGAKSRDGDGDGEEGRRTRVSRTRGTGLSTTTNAADATTTMALTIAKKTSASAARSALRPRDVDDRAFVGVLRESSLFLFSLLLSRCRPPLPSPAPASPSAFRSSCLHEPAPTPSFASPHLYTVQHGPPPPSANKYILIVAPRAYLCSPVSLRAADCPSVPPLESSSFKASSQSPFVCLCLRLEVQVLVLLIMTCPLALSPLAYLPTSLRHGRKLHCLSYPPFARPRPVSSEDRPPRAPRPIQQSTAHRAMHIRIPCFVSSHIQSPPAAHAPQRLVLGGKPPRGRARGPHAHRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUG7</accession>
    <name>A0A2G8RUG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUG7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986:SF1">
        <property type="entry name" value="BENZALDEHYDE DEHYDROGENASE YFMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="340" mass="35709" checksum="3C0430D6B57BFEA6" modified="2018-01-31" version="1">MQAGLPKGVVNFISTSKADAPARVAQIIAHPAVRKVNLKFTGSDRVGRVIAREAAKHLKQCVLELGGKAPVIVLEDADIPQAARAITSSALLHSGQICMSTERVIIQHGVATALVEELTALFRKAKAGDTYADPTANLGPLFMEGSAENVVAMINDAVAQGAKVVVGDRNRQGTIVQPHIVMNAKPGMKLWERESFGPVVAVAVVDTVDEAVDLANACDYSLTSAVWTKDIYTAFEVAGRIHATCANINGPTVHGEFMRDLGGLGGSTGYGHFRVEDWTTVRMTVLHPAIEPSYVLLGSLNATQEANGMKTGMNGAKNGENGSSVHNGASHGPNGLSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUV8</accession>
    <name>A0A2G8RUV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUV8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUV8"/>
    <dbReference type="OrthoDB" id="2754773at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="815" mass="91300" checksum="6AFBD5F858FF08FF" modified="2018-01-31" version="1">MAFYAPLRRLTLMDLEHLGLTEFLQQFSGGETFRPPRSLPSILSLRVYGHTPIHSTQFLSRITIPTSSARLFVGAKYDEGQRGETIGTSLPPNLVNTLPNVATFTWARLTLVLDWWTPDPILARSDWEERMSDSLDDLLTVFGDARLTHLEVIGLCATVTAETWITVFQAFPCLVSLEADAEAALFDGLHAASLASLAPSDNTDSQALQAPFECSSSESDITGHDDEPHVPAPPPLNGLRQDIQRRLDMLDVKEEEIRRQRLELKSAWNHSLAVTQLPNEILFHIFVAVGKQPVPPSKAERLDTGHLQVDSHLNGQKSTLLAWTMLITLNTSLEPSIEAEILLYLVYHLQVPPSVCIPIKFGQAHGDSDGDENDSSEFRLARTGWTKLMLVCHRCHDVAHATPALWRTIDVGKTTSWMKLALTRSCSATLDVSFPFHFSEEHASLLKLHCHRLRSLRLRSWSPFALRLIRNALPTLETLEIHNNPDGMKDARKGFYTDLRLSRTQLPNLHTLQLVYSLIPRDPLFYARLRKLSLKACPFKATVEQFVRLLASNPCLEHLELDEFLQHLSDSGEVRRAWPLPSLHSLHLSNHIPLHSAQFLSRLLIPQTPTSLAIEGLAEEMGDNPYTLRALVPPKASSSLPGLSTVAWARLVVTWKEIAIKCPSMESDLEEESDPALLVDLALTSSSPTAGLGWADSMPDGLTDLITLFGAAPLTRLELIGDCFAVAEEHDHGLPVVACRGLERIIISDYWGASRRVEWFLDPLIRCLRYRAERGSRLQELHLAARRPEDMVDVYLPQLEELVPNLELRYTQAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVM6</accession>
    <name>A0A2G8RVM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000046">
        <property type="protein sequence ID" value="PIL25562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVM6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVM6"/>
    <dbReference type="OrthoDB" id="5314275at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="277" mass="29471" checksum="66817163DFE4A0DF" modified="2018-01-31" version="1">MLLNEKDSSAGGSYIQTGGPYDAPPSYDPTSPGPSRVDTLKHPPIPAPFSPTPGPALFPTFAPSPDGTKGPELPGDNPHGFMGHVKNFAPGKSPQALLDPPPASFLRPPAPGLPYAAFPAMLLLSKGATLDRGFPYAAPASLGGEARGAEVGGHAHPFAGHDVNEQDWRRFLHDVRVAGSLSPMNRVVAGLAPLALGIGIIFGFFIVKGVDSVMRRTKKGPVSQLIDYWNHSFFHPRCIHIGLTQGPPKDARGKRDKAQAADKNWRLIISYRPYAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVZ8</accession>
    <name>A0A2G8RVZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_11432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVZ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVZ8"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="212"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL25682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="448" mass="49293" checksum="2F7BFCF135914208" modified="2018-01-31" version="1">MSHAGASGYGLPSLDDVLTQITTHAPNLASYLKTFAPREVRETILASTLGSGQDPLTVLDPQINTLGFLYILSARLHSTSMNQASNAALPDAIEAFTSKFEPQHARLAPDRVSMLGRDIARFYEAASNPRGAIGPLSNLVQRYPPNPSYLTTLHPIFLKLCVAHRHLTAALPVLSHHITAIDTTLSDLTYNDNLIYHYAGGVALAALKRWPQAEEFFEICVTAPAQVPAAIQLEAFKKLVLVQLIQYGEASSSTIPPPKYTLPALLRQMKNTPYQGFIKQYPGRVDFLRQIAAKDQDIYVQEKNWGLVSQAIDRAPVWLIKKLTATYLTLGLGDIGKEVGIDSPEEVRETILSMIDSGEINASISEDGTVTFADPVPQFSKDELDQMLVDAQQHSRLLFEIERGVNASKEYLTKAMRHKDDAGWGPDEDMFPMSMAGGHGWADDSSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWD4</accession>
    <name>A0A2G8RWD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWD4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWD4"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF5">
        <property type="entry name" value="MEIOSIS-SPECIFIC APC_C ACTIVATOR PROTEIN AMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="285"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="59495" checksum="347119F0DD730AD3" modified="2018-01-31" version="1">MSLRNNPFLRKRTRSIESIDESDRKRLRRLPTLPLDDEASSSMPSPGPSRGPSLSRLSLEGSFTQELARRLDQSPRRPRLSASSSFLHSAPLSSRASSIDDDGFHALIRSASASDIRRKRDSMGPGSEFPTFKEHSSFHVLKSVNNIDYSVPSPADATAGSPIGWSHSNALVFGRGNRVYYKSMADTEGVAQQLCKITDTMGNLALVQCAGEKHPNTAALATSNGYMQLWDLATKRPTLQWRMKGPRAMIFNATLLTVGDEKGALRHYDTRVNDPAKMKDQATKVTRHQGRITALAWNRDNFTVASGDQNGLILVWDIRKPRLPLEVGELVQRRRKMQHVGAITVRVFPTFSTPQGRRSRDRDVGGQALAWCPWYGKYLVSGDSAPDQTGTIRIWDIANDHGESPSSFSSSSSRTSERPKKLELDAQVTSLHFSPHINELLSTHGPGKVTEVPSLGNSIVDPLQSRMANAIVVHQFPLMRHVRTVCVARKGVAGSVLSPNGHRIVLAVPEEGQLKVWDVWGKFKAPKQQSLFESCAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWD5</accession>
    <name>A0A2G8RWD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWD5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWD5"/>
    <dbReference type="OrthoDB" id="5588482at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013950179" description="Transporter" evidence="1">
        <location>
            <begin position="17"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="31035" checksum="21AF58C0DEFCFBF2" modified="2018-01-31" version="1">MKTIAAASLFASVALAQTVTLIPSGIGSSCSSFLNEFNQDTTLTTCTSALITASGAFAPATNATATTLSSSNAKTALAAVCTASSACSESSFRSKLADFYKACTDELTSSQNKDVIRTYDVLYSLIPLKNAVCSKDDSGNYCVTSIGSTTSQSASQLASISSFISVSAVATTSNARRAEQVVAAVAPNATTFANNNLLFLLLQPSLSKDALCQTCTRNVITSYISFESSTPYAPGLAASVLLGGQSALYQAVQSTCGSTFLSGAVAAAAGLSGGVVGQASDSGASRTILSNSGIAGALVAAVAMALGAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWE1</accession>
    <name>A0A2G8RWE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWE1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="129" mass="14057" checksum="809176D9301D6735" modified="2018-01-31" version="1">MLDSASPPPSTEAPSSWNTPLSAAGASLPTLSPFLGTQPDDGLTGEEKAARVHIEKELTRAYAEKETVSAEIASLCAAETVARRMQEMPLDSLPQHWTTYQYGLSLRAHQARAMWENIGRDCKDAGREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWJ0</accession>
    <name>A0A2G8RWJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RWJ0"/>
    <dbReference type="OrthoDB" id="2019644at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="612"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1925"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2121" mass="234637" checksum="9A8DDA8D96CE6A9D" modified="2018-01-31" version="1">MSSVSRLRAVLSSAFSSRGLPNGEQEFFEELMAHRPQLVNLYDVGPRNPQEQRELESGKITINGRSVAVNGDFAKQALFISQHLECSERYAAGLLQDVMTHNPNFTPERCIEAAIMEFHTRRRELADCLGTILQAAERAETGDASPLHQRIDMFVRQQLLYPQGTAGAGLSLAMKLFQEIHSVGNTLAKAQAARQNAKSETVAPTQGPNAGLGVDVLNARCESLKYERRTLAVALFLLARMGHLSSKEIPKVVDWLSANPRHPMVFYLLPTVLTAFDIVDPESTAGRARKALLADGQLVPDMKRKLDMTKEWPEQGLKATILLKWTLFLASARRADPALENTDGFKSDELETQIWNSVQGDCFTYLARTLTLLQKSQIARSTTSYAASVLTITEQDVQLELPSDDFRPVIVEASETLVRSLITQASSELRKIKQRQEDLLLAGARADRTRMFRSTHPQGASRSGAPEQERPTTPPRNDMAMLFSFIGMLYTQLPPKRALHFWGAGTILPGQRSSYREYVELSSGKLAAFLQWSVWSTQTRDVDMSMALFDMLSGLANGQQCSELAYNYLVRGGGDVVPGAPVASTSSAHLNAGPTVSWSSIFSILESWAAAGQPPRSNAPQQFTPTQQGFGNSHFNQPPPSPPRPQQIQLSQQDVLLAQSFLRLLSVVVTNSIPARVNISSHARFRAIPTMVSLIPLGLPLELKGAVFDSLAAFCAPGAGAAGVEICKSVWTLMERLEVINVRVPHGPSGGLSVGRGVELELDEVEAAYKLYPSTIPFLNLLAILIHTPKRIPLRERVADPTPVNTIPEALGSPYRTPGIGPFVSFVVDNVFARIPTREYLRPVDRWRMNDLCLCFIERCLASFELESLVTTIEELQPNKEAVVQLAIHPGFELLRRLLTASPLQASILSYLVEGLNGFEKGLAEEEPYYRTTIIRVLRIIHRVLEIQDIFLDVFLPLLAELNEPTLTGDVPPASYFIRFDQALSFTPDYVPALAAYICYPAYPELMLLSVKIITMLASSAALNQLVLLIDRSSESIRILEGYLRALDAGVADDVETAETTADQATGAGAPDPDEPSDLLTQAIRLAILDLFIQNTHSGRAHPNLAHFLLFGDASPDKSIQDPHALGARRSCVHSILDLLNFGVPRLKGKERKQTLGEPLFISLPAFAERCYHVIFQLCQHPRTSEPTMRYLRTREDFFARHLAAIPFKVPETEQQPFIEIQYGDGSRVVTTVTTTASFLKLRSWILDLVALDLHVLTNKGHQKSVSELLELLFGNEEDGLEDGTDTWDVDVFKPFREVGQSHLRMIELVQSLDFDWSDSLVVQPQNLDFLGQLNLQSCLRVDESGCEVVDRAALLSLLTVAKRALYLQGRVATKAHVDALEAETNYILESCAIENHRRKVHYAAASGYESWRRVLDMALMKSFDRLPFDRRENMLFDLLHVLPNSLRSSNINESTAVLLSETILSTITKLREDRRHQVLMQTAGGDVEAGSLPAERLNALLRSILECIVDHSRIELVRGNLYASLVNYLHLVLHAEAPESSGDDVPSILASSVSPWEELSDSLSLVSVSGQLTRPPVAGGSLIQSSIAILKPTTERLVAIVSRDAIDGTEVWKTVAFMLLDSLVRLSRWEKHSSSLASLARQGFLGGFVRGLKESDLPLQGVLKPDPDDLNPLYVYEAKMSLLVRMAQSRQGAERLLEARVLPILGECDYLDARPEADQAFLDRDSFLPSAVQRYHQLFLPALQLVSGILIALGPKHTTAANHALQFLSSHRDTAILLLKNEIDELSISVLEEIRLLVSICASVVHLVPKTELLSSSGFGALHGAITSLGAKCLPDRHWTEIVKPQTDAEFADASVQSLEYAPQSKFRAALLLKDELLKNAITSYLGTASDFTEADFTLVFSPAITTPKHEERSAKFIATVPSIGEAIEALDDLSRNLSQVLRRIVDLSAELASKDHIRVDNVQEIVHVSDPTVLENLDMRQKQTLVGRELAAWRTGAKRRALTILNSLEMLLLLLWRHLAFYLEGKHVNNSDLRGPITHTMRLASAPDVDTLRAEAQRRLVPVLSALASLDLSEDTLGADWRSYESYRTIMARRLADTAGLEEVEADVRGSGDSPQNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWL8</accession>
    <name>A0A2G8RWL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWL8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWL8"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="734" mass="80881" checksum="CB5EDABDEE4A78C9" modified="2018-01-31" version="1">MSCCGEPSHKTDTAQAAQYVTPFQTQPITQQPAPQPNLQWQQPNMNEKGFPPQPGVGPTPPPQAHQGYGNWEKTSPNQQTTFQPYVPQGSPPPVAYPNGAMPPQQTGSPPPATVSSPYSPYGAPGPVQTPPLAHTPEQRSVPMSVTTRGPSPPSMSQQLSFAADEGKLSVSIDFGTTFSGVAYGSSRIAAGKVQQILNWPGSFETFRKIPTCLLYDPNGQVMAWGIEAKNAGPMPGAVKCEWFKLFLEPHALRDSSNVDPRLPALPHGKRAIDLIIDFLSCLWDYAKQQITREIGAVADLDSADVWLTVPAAWDATGCQMMRDAAIAAGLVRSARAGDNDWRDRLRIISEPEAAAVHCANLTDVHKLTPNQNFMICDAGGGTVDLAVYKIIGMLSQLEIAEMCARSGANCGSLFLDLRFRELMRTLLSDHPVHLDPISLANFMEHFSETEKLRYTGQEDDDKMFHFTCFNVEDPDDPAVGLVNGEVTMPGNLLRREVFDPVVNQVLELIEAQTKKVDQRLDALLLVGGFSGSEYLFRRVREMFGSRIRVIARPSDCDTATVRGAAQYGLARRALVSSVIAPQSYMLKVKLPAEQEDWLKRPAYIRENDAGVSICENRLQYLVAKGAILRKGQRLKTTFCKFSQTASDRTFVATLYTSDSDKIMRYTDEGEIMELCKWTIDLGALPSFQQNASTPNSNGFYTEFELGLELDSAEVRGVLIYQGQDWGRVVFDYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWQ7</accession>
    <name>A0A2G8RWQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWQ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWQ7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="11528" checksum="F7A998471FF02E7D" modified="2018-01-31" version="1">MSRFQVSEEELINYQMQPKPVEPTQPEPERERDYSARIHGAISSYSNSILSIGELFRDGQKGVRFPKDLIKGLEQKLQDIAMGKDPAYAYIWYKCEMASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWV2</accession>
    <name>A0A2G8RWV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWV2"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="22"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="345" mass="37795" checksum="1A357BB4DDC8648B" modified="2018-01-31" version="1">MAPVKNGRVIFNEMPTDYPIPGQTTVYDESETIDLENVPLNGGILIKTLVVSIDPYLRRMMIDPKTPSSFPPFSIGQTLINHAVGLVLRSENLAIPKGSHVAGLFPFQEYAVLSGPVSPRVRVVENKENLPWSVFVGVCGMPGQTAHHGWHEYSHSKKGDLVFVTAASGPVGATVVQIAKAEGLRVIASAGSDEKVEFVKSLGADVVFNYKTTKTREVLEKEGLVNIYWDNVGGESLEAALEFAAPKSHFIICGNISGYNTGEPYNVKNLQQLVWREITFHGFLVDSLMPKYREEFLRTFPIRVASGEIKYKEHVVHGLENAGQALLDVMKGGNFGKSVVIVADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX31</accession>
    <name>A0A2G8RX31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX31"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX31"/>
    <dbReference type="OrthoDB" id="3261349at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="269" mass="30260" checksum="7BB932724282D6E2" modified="2018-01-31" version="1">MSTASDSDALAADILLISSSTQVNHIVQAISFSACWYPGAPTVPGRVLISPRATAILYFDFFLTLPAEVDRYWTGNGCSWASFFFFLNRYMSVICHIPIIYEFFWSMPESWAVLGGKGTLPDSHDVSRWVGCDLRVTQKQGYYVAASWSSVLVFDATVFGLTLWQALNVGRMWSHSLFHIILRDGTIYFWILAVCYTANIMTNIFAQPELKGVLTTLTNVCVHRLSFSVIGPSSAPSISTSLVSRMMLNIRNPELLELPHRWPSEHWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX87</accession>
    <name>A0A2G8RX87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX87"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX87"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="529" mass="58814" checksum="3583F1485E3A44F9" modified="2018-01-31" version="1">MTSRAAEAGPSRRISSSYRPPMRAPTAADLEEESFGSVSEGTATEGESESESTEQEYQEAIPSRADIKGKAPASPAGARAPPAAAAPRKKVGSWTDLDLSIIVALVSPIGNWLTGGDHIKNLFLIILLIFYLHQIIEIPWQLYLGARPRKTGHRIPSVSGEEDERVAHLIALAHRELYRHEVVYLALAVLSPLGGALFLRHVLSSLGEQNSISWFSTTLFVLATGIRPWTHFVNRLKNRTHELHTALHYPDEDSLVHMYEQTNRALQAAHKRIDALERELGVLRESLKRAEQLREVCDDLTEVLGELERAGKRNERKADAGRAAQSVRLTSLEQSVVQLEQRRQRDIAAFEAAGLRIPKGDAFLQQAWFSIMTAVDKILCVPRALILFGLEDPCATQKTASPKEFRIQLPPNGVNGNGTLHARIRSPDREKHLPHLVPRLATIPEAEDSDSEETFVSDKETAPPPQATPQKHVRRRSTSGGASSHRPRIKTFGQRVFEFAQDVVLWPYRFSVRVLVALLPPFKNVMPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZA2</accession>
    <name>A0A2G8RZA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZA2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZA2"/>
    <dbReference type="OrthoDB" id="2752681at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="631" mass="69890" checksum="89326D288C0C36AC" modified="2018-01-31" version="1">MNQRIPGWVRDAYDRLWSRSEDFTAERRGLTVLTCPPPSNLGQRVIAVRDDYLQLWDFLKDAHHGKHHGGIVLTGHPGAGKFCFLLYAFARALREHVPVAFCNSPDEYYYCDRTGCRLYPTHGLVLHEIKLQDGKFSLVLVASSESVPIPPYKFINTSQMCFTVQATSPQSALLRCGRWVREREASYWVIQPWSEDEVRKLQHFYEEEPEGPHPWKNNDAYYSPLETFALLGPSIRKCFCAHGNRKTAHGPAHDFEAFLRPDDIFDDMDDFVDGLREQTMASLRPGGPDFHRLFVASKPWDISNPMRYSLLFHHAVPTLFLQRLLAARFRRRTTSEQVALVSNIPRIPQLKGLSFVYDPAILDLLCRPQRASPSAPCGPSASASASPSTTTTTTNGHVLRGSQQCQCHLADGTAFTLGPGLALASEEEVTPSTPSVALRDNHVYLLRSGSGFPWIDAFVVTVGEARPRPRTRVTLLQTTVCYRREVVSSAVRRVVELVRRSTPAPDPDPDKGGGGGGGGGGNGGEAIEWSFVFVTPSGRGEKMAKTVGEVQFRGRDWRHPAVVAGWLEVGALLGYAPEVVDALKRQDAESVGEHVDDDAELATHVHKATRLDSGCVDWDRLPPGGSLYGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZD6</accession>
    <name>A0A2G8RZD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_11061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZD6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZD6"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="454"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL26881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="544" mass="60892" checksum="1CB27319CFEBCE81" modified="2018-01-31" version="1">MYSARRSLDPEDPFAAAMAPPPGETADERAARLRREADAKRVNDEIEETIKQDRAAWKTHKNMFKLLLLGQSESGVLFTDFQLVFAPKAWRAERASWRAVIQLNLVRSINSILDVLSAEMSKSPNPTSPHHHPDTSDSPGPSSPLSSALAFQFSHTHALLKLRLAPLRRVEADLKQLIGAATHELVEDRPFDAPLSLSPSDDLVAAAPFLDGSGSRRRPTEFYVRANNTWREAVRSAYHRIAGPAGEDGGGGVRPSADGSKLEDATEIIASCAADMKALWEDQVVLDLLRRRKIRMELSPGFFLDDIDRITQRDYQPSDQDVVRARLRTIGVQEYKLVMENYDPPPAATEVSREWMIYDVGGSRTSVRPLPFPSLPLPLPISVSPFADPPADRAAWFPYFDDAHAILFLAPISCFDELLAEDHRVNRLEDSFLLWKGIVQSKLLAKCIIVLFLNKHDLLEKKLAAGARVNKYLPSFGDRENNAATLARYLHKKFRDQHREYSPHVGRPFYGYVTTVTDTKATASTLTSVRDGVLRHNLEKANFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0C5</accession>
    <name>A0A2G8S0C5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0C5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0C5"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="168" mass="19003" checksum="1B7ABD4AA83ECA05" modified="2018-01-31" version="1">MSTQTMAEYRQLGKSGLRVSVPIFGAMSFGDRRWNSWVIEEEQELELLPYCEYKGIGVVAYSPLLTGLLARPVGAETDRSKATIGSPFEKKLRESDSKIVRRVEELAQKKSWSMSHVALAWVASKTTSPIVGLSKVERLDQSITTGKVLSDEDIKYLEELYEIQRPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1U4</accession>
    <name>A0A2G8S1U4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RING-type E3 ubiquitin transferase listerin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_10874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosome quality control complex (RQC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S1U4"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054477">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22999">
        <property type="entry name" value="LTN1_E3_ligase_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin N-terminal" evidence="3">
        <location>
            <begin position="83"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin N-terminal" evidence="3">
        <location>
            <begin position="375"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin HEAT repeat region" evidence="4">
        <location>
            <begin position="1404"/>
            <end position="1617"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase listerin ubiquitin conjugating" evidence="5">
        <location>
            <begin position="1633"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1762" mass="194885" checksum="8AD5DCBB4CEAB85B" modified="2018-01-31" version="1">MAPKGKSSASSGTHKKHARKAAAAQGVVEEPPVPKEKEKKPKGKDKKNKKEPRKKVYIPPVKPAPVLPDPLDTLGLAQKLPAELVVVLRLLGKKDATTKRRALEDMQTAWLGRAKKGEEGEYLVYTLQEIVPVWLHHLPALFIHPSRRIRLQAIGLHSSFLQIPNLRNQIFFQIREVLSSDQTESVLGSWCLAAHDADRQVSSFARDAWHRYVSTSESSPDKLLLDASLLPRLWEFAQRTLLDPAGVYLYINPPQPVIPVSTPGKKGSGRGTPVRRDPEPASPRAKADEDEENEQDRKARLRVGAFGATEWVLNAKYATPSKAEEKAKASAVEGGEKEKEDVDDVFLQPLTNPALWSSLYCGKTPPFVETESFGFEQPVVRRSAWSLLQTLVQKCKEHLDPLVSVLSGAVLRSAWVEIDPNVKGAMWQPLLVFLKDHPNAWTLEAEAGREDEDESDSDDDEETPKPPSKASTLPSNPSQAYTEFLQFLATGCSGSPLQGYPTILIILSTIPSSVIAASSEHPLEDLFTSFWAAVDARVLNSLDRVAASTAFLASVLESLVFVSRRIFTSPEGEAASLINGKAVAEAQTNTDADSAVKALIQDQTKRAWEELSSGRLKVEGKAAGAELAKTFTELHKLRTDLFSAAWGVISSSVQSALSSTTEIVSVPAFVSELLQQFSVSLERGTAPGNAAHDLLLSVVRTTLDQCASLLQAEEVEDARVSSLVCILDKFGELVFSDEDLAKSVDGLVQSQTNRLLATMPSLLLLYLKFRDDEAAALSVWHRVLETVGRSPEEFNAMFPTLLDAAESKQLPFYLQPQGEELEQAIGSLLAAALYVSPNPSRALLIRRVLVSYEHFLSRSSREKLLGTVADGFVLTLKGALRDHGASIDTFTPTLDLLHGVIEQDPSSTSIESFASSLIPHIFLLAFLLPQVRPVDAKQQAAAKGLWVKWLANASEEAKETARSTIKDLLRELLSDISSQPTPEQLLRTISAFSSSAEIDVLADIFPSRGELDGMLDMLPSTPLDSSLAVVDPLVPPRVQYRSLKFQKDGFDAQGLAKYARIVQGLLLHLVDDRQTAKENPWVLHHFLALALYAEESRHLPSAESHVFSCTVSRATLQDILHRVQQVTTYLLTSTADEKWHTAVTNALAGQAAATGLDGVGQLVVDLVNRVRRYDSIRESRILHTILRHALSTATKADAEQWITSHLLRNQPTRLERFRNELAAGTLGIPASKANTEGLWLLRNLAASAPDPESDIVFLPQQRAVNLIKACQQWITSDEDLEEDVQSEMTLVFTSLVPILSNVPGGHWDLVFDVVENNLENATLEDPSTYVSLSRTLQLFLVIEDFASSNKTLKAVWDERRSANLTLIRDIISLKLDDAKFSTPLSHCRELALQIVQDLPTSLLTRETLPKMCHLVTDGSVDVQRMAYQLLQEAAKKYTEELVVEAAVDTEDSVKSELPTELLDILQRTLNQEEGEEYGQDWFGYILAWMVTFDLFTGASLKVKSGYIDQLKDLDLVGSQLLPAVFGLLELYGGMPKAFKLELWDVDEFYFELYNSDTPLSLRLLTAHLYYRALLIVPSLVRAWLSDCRDRQLHTTVIAYTSRHFSPAIIRTELERVKDPDAVQELGGENENVTIKVASAVNEVTAAYAVDELKLELTIKLPVDWPLHTIDIRDSRLVGVTEDRWRAWVLGVRQILTFRSGSIVDGLSFFLKNVTSHFEGIAECAICYSIVNASDGSLPRKPCKTCKNRFHAACLYKVRGALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1U5</accession>
    <name>A0A2G8S1U5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1U5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1U5"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="212" mass="23748" checksum="DA404DABA3BF5A9D" modified="2018-01-31" version="1">MSTLQLPPGLTYDRPLVETTRGGVVDWVDYKSVKLYTNAFVISPDSRKVLLGLKKRGFGVGLWNGFGGKVDPEETPLQAAIRELEEEAGIKAPLEQCGTLFFAVDGVDAAFNIDVYRAYEYTGTITESDEMRPQWFSVQDDLLPRGHLPANTGHAPAEDSAELPPVPLEQMWADDEFWMPLMFARRYFVGRADFNADNKMLKWWFAGSPPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2H4</accession>
    <name>A0A2G8S2H4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000031">
        <property type="protein sequence ID" value="PIL27983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2H4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2H4"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="5">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="152"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="495" mass="52871" checksum="89079FD5055B3D91" modified="2018-01-31" version="1">MSLCTSPSIPHQSALIPILSHVFGQNGKKEYGFDNIKVTNSAWDTNVISASTRYVSLNWNSSGGGAFAVLPLPSPFAPLPTGFPSKLPDLIPLAPRHTAPVLDTDWSPFNDSVVASAGEDGKAMIWKVDPSIFEGWGQDGWEPQDLDPVARIDVSPRRVGHVLFHPTANNVLATSTGDHVVKLWDLAGPENAKDRKIRLFDPRAGGDPVRVGEGHGGIKGARAVWMGDKDRIAMTGFSKMSDRQVALWETGGLGNVKTITIDQTSGVLMPFWTDNNILYLAGKGDGNIRYYEYENDNLFMLTEYKSSDPQRGMCFLPRRGLSVSDCEIARGLKVAASSIEAIAFIVPRKSDSFQSDIFPPALSAEPALSAAEFFSGKSAAPKLVSLEDGSISAGSAPISVLTPVPTKTTSAPPPVASVAPATVVREDPASSSVAAPRGGSMCSVSTSRGATALEEDNAWPNTRLRVDPLPRAASRDHLHKCAQGGEGEIAVRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2Z3</accession>
    <name>A0A2G8S2Z3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2Z3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013721931" description="Transporter" evidence="2">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15536" checksum="1C669BFF9E2A3E6F" modified="2018-01-31" version="1">MMHLAKFVLAALVVVGAIAAPADSPAADAVSVAASVPAADAGDVHHPKHHKKPHHPRADPVADVGDVHHPKHHKKPHHPRDDPIADAADVHHKKPHKKPHHPRDDATAEHPKHPKHPKEPKHPKHPHTSKHPKPAAATAAADEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S356</accession>
    <name>A0A2G8S356_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_09618</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S356"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="15">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL28206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="670" mass="72540" checksum="7195AEE9CCC8CDB3" modified="2018-01-31" version="1">MTGWRNVGEGRIWRSSNVPFHARYKGWTDRPQDLQATSFPSSLGQTFNGLSHPPALPHYRIPFTDHTQNPRSAMFSFNKVFASVFLAVLCASSATAVPFPASSKYATHRIREISRDFKLEAYHPESSYETFGEGIDHPLSKRADASLEDSAVAFVQSRSKLDSDAVHVRSMFQSEHASHVYVKQQANGIPFANAVANVALNKDNKVVAFGSSFVQVSKVADSKPTVATEDAIAAAEKQLNGTFDAENFPAPTLEYFAKEDNTAALVHTFQVRNEAAGTWFEAFVDAHSGELVSVTDFVNKASYLVLPIWKEYPTDGFETLTDPQDTTSSPQGWHTSGTTTTSGNNVIAYKSSTSSVTSESGSGLVFNYPVNFATAPTTTANVNAARVNAFYVVNTVHDIQYKYGFTEAAFNFQTDNFGNGGAGNDRVTVSVQDSAGTDNADFSTPPDGQSGHMRMFLWDLTSPERDGALENDIIAHENTHGLTNRMTGGGTGRCLQTTEAGGMGEGWSDAFAEWTTHTNSSVPDFIMGAYAIDDAAGIRNYPYSTSATVNPLRYSSIKTLNEVHNIGEVWANLLHNVYAALVAEHGFSDTARTDATGTGGNVVYLHLFIDALALQPCNPTFVTARNAWIQADVNRYAGANECLLWKAFASRGLGVNAASYNDDSSVPSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3Q3</accession>
    <name>A0A2G8S3Q3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3Q3"/>
    <dbReference type="OrthoDB" id="2802798at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="182" mass="20311" checksum="16E1CA183CF234AB" modified="2018-01-31" version="1">MLDPHHYVEALNLFGLLDRPEMVPAAVYRCCQLGPGALLEGVQREDGSEALERLSPEDLELCMETVPRLMRATVRVMMGLTDLVEARMSLVCAQQPDCVMPKTCVGGLAAMLGEWRDHMAYRVDTDALGTDFSEDVDTRVCRGAMCRVCGDVLRAAHRRFRREVWAALPRLTETDVKGWNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4U5</accession>
    <name>A0A2G8S4U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4U5"/>
    <dbReference type="OrthoDB" id="2803586at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="43025" checksum="5288EEC9C891A072" modified="2018-01-31" version="1">MPPPLKSKQNGATQSTATSSKTQHKQRAQSQKGHGTLDAMFASTSNATTANGAPANGAPSTLDLTPTNEPCLPSPSIVGLTRSQRLFSVVTGVDPRSLVFGKGTSREFFLFMELRATHQWATFQMTPYDWVCAASMYNTAIKKLNYEHGAALPLKTPRALLDKLSEVETLVFGRIRDNNYRSHSGGTSFWEHHCKVVYLGAKIQRMVDDGKFKMSKNHICGHCKRIMYPGGKNHKENHARKVCSDGVRQSAEKVHLVINGISRDFVEQPPPFPQPKDVFTNGNVFHPARFMELVRSLYDRIIVNQSAPGSLAMHDYAFAMLLKDRMVIVPGLDGRPSKAMFKLFHSFTMASGEAAVLDDHEGEMCLRMDCLSEPPLETMPDDRQEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4X9</accession>
    <name>A0A2G8S4X9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acetate--CoA ligase</fullName>
            <ecNumber evidence="1">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4X9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4X9"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="230"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL28784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="354" mass="38922" checksum="A09217052AFB36B8" modified="2018-01-31" version="1">MADIGWITGHTYIVYGPLANGVTTTVFESTPVYPTPARYWQTVDKHKLTQFYSAPTAIRLLRRLGEHHVQDHDLGSLRVLGSVGEPINPEAWHWYNDHVGRRQCAIVDTFWQTETGSIVVTPFPGAIETKPGSATVPFFGIEPVLLDAQTGKELEGNNVEGVLVLKTPWPSIARTVYQDHNRYLETYMKPYPGYFYTGDGAARDEHGYIWIKGRVDDVINVSGHRLSTAEIESALITHPGVAETAVVGTADELTGQAVFAFATLKPEFKYDPNDEGGLIKELTLQVRKVIGPFAAPKKIFVVVDLPKTRSGKIMRRVLRKIVAGEGDQLGDLSTLAEPAVVDSIKEKVASALAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S626</accession>
    <name>A0A2G8S626_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_09288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S626"/>
    <dbReference type="STRING" id="1077348.A0A2G8S626"/>
    <dbReference type="OrthoDB" id="65434at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="235"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="547"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL29239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="679" mass="74400" checksum="4DCB48276060A1DC" modified="2018-01-31" version="1">MPSHPSPIALNPAAPTQSIFKKKKSMSGLPTAASYLSAVSVADARARAHGATPTSTPALSLSSSVTSSSEDTVLEETSDDFTDGLSYPRVPPTSDQVFATVHSEFGHCANEDYRYTSQHRAGTAYKSIPERDPPYYILLTTYISYIIVICLGHLRDFLGKRFRPASYRHLLPWNGYAALNSDFDSFYTRRLKLRIDDCFSHPVTGVPGRTIMLLDRYSPDYNKTMVPTGTRTRALNISSYNYLGFAQGKGACSTAVEVGLEKYGFSGGGPRLEGGTQDLHLQAEALVSRFLGTEDALISSMGFATNSTIIPGLVNKGCLVISDELNHASIRFGCRLSGANVRMFKHNDMKALEDLLREVISQGQPKTHRPWKKILLIVEGLYSMEGTLANLPVILELKKKYKFYLFIDEAHSIGAMGPRGRGVTDYFGIDVKDVDILMGTFTKSFGAAGGYIAGRKQIIDRLRIQGHSGTYTEAMTPPVLVQIIASMASIMGITLPAEKPASPTLALLRSAEQTPVISECDIIPGTVPASALPVWMPLSSTMVDGSDGKVRLRRLAFNARFLNRGLRKLGFITYGHDDSPVIPLLLFNPGKMAVFSRMMRTRATPIVVVVVAYPATPLVTSRVRFCLSAAHTKEDIDELLRACDEIGDLLDLKQAEGERWPVEEIISRAVELVRMPECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7F5</accession>
    <name>A0A2G8S7F5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7F5"/>
    <dbReference type="OrthoDB" id="2576311at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013647911" description="Extracellular membrane protein CFEM domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="51647" checksum="32AA0746374937C2" modified="2018-01-31" version="1">MLPLALLPLELLLVGLVVAESLNNNLGQTPCTVATQIQTACQDRNEAVMQTCNCNTVYYNVWAACAACSGQTQPTWSDWAGNYSCKSRQASFPPQVQFDNGVIPDWANQQLTSDGDFDLTAALQTSLSRPAQIAVPIAVGVGVALLAGLLFCWYRRRKWRHQRNARIRPLSDGWLSSPRQWFNDLWLRAHSTRLKASKKEPSWEIDDEHLSWREAYNDPYSPPGHRQKHELGVRPSHNREASSSTLLSHLEFPTVRRVPTFLERFIKFKDGIRKSATYKAKYVSAISPDHTFRIDGSAANSPITKFEDHALDGAASHCKSGSDPQASFQPHRVSTVREEDEDTPGGAPVIVDLADFNLGPSQYPAEFPSEVLVISRDGQDFALDDMSTAPPTSLRTPTVARQPSSVYSGPPLSGVSGGSWGQSPRRANTSSTVSGAYPHSLRRDPDLTASRLPAPPQSLYPASVRAVMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Q4</accession>
    <name>A0A2G8S7Q4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Q4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7Q4"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="520" mass="57870" checksum="70107FFFDC210F41" modified="2018-01-31" version="1">MASKELKKFTREEVEQHNTEDSLWIIIDGRVFDVTRFRNLHPGGPTVFFDEGIPGGDATEAFFGLHRFDVLEKPQYQRLQIGVIDGEEPTIQGGILRGKVSQVPYAEPSWLADGYYSPYFKESHRKLHKAVREFVDNIVYPDAQERELDGKRPSQSVLDKMTEVELHAMRMGPGKHLKGRTLMGGIVKPEEFDYFHELIINQEIARCGARGYGDGLQAGCVIGLPPVLNFGSPELKARVVPEVLSAKKFICLAVSEAYAGSDVFGLQTTATKTEDGKHWIISGTKKWITNGTFADYFTVGCKTEDGFTVILVERGEGVNTKPIKTSYSSTAGTAYITFDKVKVPVENTLGEEGGGIFVMLSNFNHERWVMCCTSARSQRAITEECMKWVNQRKAFGKPLHSLAVVRSKLAGMIQRSESVQNWLENITYQMCNMSYKEQASKLAGPIAFLKSYSTQSAQLTAADAVQIFGGRGITQTGMGRFVEHYHRTVTFDALLGGAEDVLSDLGVRQAMRTMPKNTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7W8</accession>
    <name>A0A2G8S7W8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7W8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7W8"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013431992" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="666" mass="72309" checksum="215937285E9760F7" modified="2018-01-31" version="1">MLGILLPVLALELCALVFGQSNSGVPNSFPHAWPGQPNTTFGNDWQSYFEVTEKLPNITGALPALPRSFAGNIPVNRSGHPNDTLFFWAFEKVGKNGSLTAPADVNNTDPWIIWLQGGPGSSGMIALTTENGPIHVLPNGSWVFNNFSWNNLADTIWIDQPVGTGFSTSDTTGYVANEDQTGQDFVGFLSNLVKVFPSLAARPLFLTGESYAGTYIPYITKHIFQTPNPPVNLRKIAIGDGSLGSQATVEHLPVVNVIETYPALIGFDEDVFNYFREQTHLCGFDLNLTYPQNGHFPTLNLVRPTESSAFSESLLDPAESRASTLKESISEKFAAVHGSPSLAKRAELHERREAERQQWKRDLSGRANGTIDPFYGCSLLDELIDYAVNFTFPWSNGDFDVYDIPDATSPEPFKNASSFFNNDTVRAALHAPTSKDWIRNFNYPFGSVHNRSVGNQYGDPSVEPIAFLSELATNASAANVSIVFYSGNDDSLVQHRGTEVIIQNMTFGGQQGFTRKPATPWFDDDGVFAGIVHQERGLAYVLFQGAGHLVPMWKPAQALVFLREFVLGDNLNGTVSGTVVVGGENSTLANDFLPGGNVIFYGSSATQYTVTVPAASQSAWSAFIATAMATKSPLEHGANGALGRWLPGMALAAIWGTTAALWMVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA01</accession>
    <name>A0A2G8SA01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA01"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA01"/>
    <dbReference type="OrthoDB" id="2729743at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48960" checksum="90514CCCD3264AF5" modified="2018-01-31" version="1">MNFSAATSPHVPFDVQLLVLDQCHKEKLSLFACSLVCRAWLGPTRVHLFRDTTIKVPHRTDEPVRKFIHALLLSETELGRNVTTLRIVGSDRFTPWIRLRNPYSPMVLTIAFYPMFSRLPRLRRLSFVNVRFVTLDFAMSHFVCDDDDIRPSLDYLEINSCLDDGDKANGTVNFITLFASIRTLVLDLEHYGNTLQRSVERIPHNHPVSIRSIILRGMVDWWSSCLSHHFRHAVPSSGDVPHPSECLNIWPHWGREWTQLKGIGSFVELNAPTIRALRINSMQLMVAKPEENLAGHWHELRLASCVHLRSLLFSLDTTDFAPDQIPDAVRRAHESILEILMDPALPAALECVMFHLTVPVESHPALAAFNWEFVDEVLARSVRRLRAVVIEFAAGSVAPTEKLAQRLANTRGILEFRVGETGVPWWEVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB76</accession>
    <name>A0A2G8SB76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB76"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="15688" checksum="2467B091F39DEAC4" modified="2018-01-31" version="1">MSTPFKFLLATPNRPVLHLYPPSIILPPSSPPVPLAQHVRTPPRPAGVHEGRRRRGVDRGLGAEHLLRGLHMWVLLPVAVGGRDGRRRMQPARHRPRSARGCGSVVNHGMMGFRVRVLSLRSVLCLCAYSRRPVQHRASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBU0</accession>
    <name>A0A2G8SBU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBU0"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013668105" description="Protein-S-isoprenylcysteine O-methyltransferase" evidence="6">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="219" mass="24733" checksum="1B9A2DD34999C02D" modified="2018-01-31" version="1">MTTGTFHIVKALILLLVMAAEYKSWTPPHWITPQKAEMSRYPGRADLNTRFPALLSAVTLTQTGAKWARDTVGCRQTGEHPYVRSRCHPPHPRRRGRKTCYDALGQLFTYELAVLEGHKLQTSGPYAIVRHPSYTALLASTVGLLVMHFSPGSYLFESGALEQPGLAIMAVAWGLAVANFSRVTLMRIPKEDAVMKREFGKKWEKWAKKTPYRLIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBW7</accession>
    <name>A0A2G8SBW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBW7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBW7"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="207" mass="22599" checksum="CB10672E8D2E902C" modified="2018-01-31" version="1">MKNGGVDTRDEVIQSFILWWTIFLTSTSLFSMPVPADTSSSSNAVIHIHIPAPAPEPEPAPPLSEEEAAHYYAGLPTRPRLLARTSTTPWVPPPSPGPHAHLRYKRKQFSAVGIGDHALAPMWERPVAPKVVAYLNERGVNWTSVDVVRIWEEGEAGEEGTTPAPVVLWIGVAPRSLARDDAHAAAFGCLEILRGFGVTDVEVEIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCG4</accession>
    <name>A0A2G8SCG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCG4"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="318" mass="36462" checksum="B7FD5227D1665777" modified="2018-01-31" version="1">MIHKVGLLPNFKSYESVSAFWIYILRELYMSELQAISDDWHKYLAKFKELEPRDVHIDFVGVWYGFALHILRIRRMWVSSSNSQDTVPSVGDVVPTTLPFTGSNTSIRVFRQALALHEPRARLHPKFYQQFDTQAGVDTTDVQEVWFAGSHCDVGGCAVPKDTPHSLGRISLRWMVRECFRADTGIQFRADKLRDIGLDPASLYPVVKDRPRPLQPRSCHLTTLAPPVPPASEEEHDVRDALSPMHDQWAAFSLLWWVLGLLPFWQRILPAPPSEWADSRGQRQTVRMSLPRVLVTPKDNSRIFAHPTVHIREQANPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCN5</accession>
    <name>A0A2G8SCN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06238</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCN5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCN5"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="517" mass="55734" checksum="A20F93DE81727593" modified="2018-01-31" version="1">MSTLGSDISNDKEKGGVFQGLTLPVYEGATEKVIVKRYGRLGPLLSKLFASGVEARGVERVPEDERETKNMWNNLLMWWSVNTVLTTIPIGTLGQAFFFLSLPHTIATILCFGAIGGLATAFISTLGPKTGLRTMIITRFSSGYAGGTIYSILNILTQLGFSVTAVILGGQTLASIKPGTLPLVVGIIIIGILSLIPCFIGYNYVHYYERYAWIVIFVIIMFLWGLGGHAGFDVNAQKPDEDRGRALSADILSFGGIVFGSFTGWAPVAADYNCRLPADTSSTKVFLLTFFGLWIPICFVEILGAALMTITDPAYVQAYADGSTGGLVAQVLAPWGGFGKFLLVLLGLSVVANNIPNTYSAGLAMQSIGRPFAMVPRFFWTFLAFVIYTVAGVSGREHFSEILSNFLSILSYWTAFFIVVVAEEHFIFRRKGGPLGGYNLDDWDQPSRLPIGIAGILAGCFGLAGAVVGMSEVWYTGPLAKKAGAEFGADLGFELAAAFAGVTYPPLRWLEIRLTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCR1</accession>
    <name>A0A2G8SCR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sphingomyelin phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts sphingomyelin to ceramide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acid sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCR1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCR1"/>
    <dbReference type="OrthoDB" id="282973at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006685">
        <property type="term" value="P:sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011160">
        <property type="entry name" value="Sphingomy_PDE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF27">
        <property type="entry name" value="ACL091CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000948">
        <property type="entry name" value="Sphingomy_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013930159" description="Sphingomyelin phosphodiesterase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="248"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="138"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="141"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="270"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="662"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000948-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="694" mass="75325" checksum="66F9492D8581DD69" modified="2018-01-31" version="1">MGLALTVLFIAVIMVSRTILSVAAASVAAFSFPAFAEPIPSGALGPSAFTAPGAFPTSLYKHYYNNPTATSAQPQPVISDPVTHKTYPFDLTNPATIPKNDTKDPHILPPKAASRQILESAFQQILSIANNSNFGTNCAKCQAGLQAGKFLALAAPELGPELAVRVCEHFNFNSDCATQYGIFSLGSVVTQVIAAADVGGLDGQMICNHFLSGLCPLPPTSPLDLTNWFAKPKPNPLPAAKTPSGQRLKVLHLSDLHIDPRYTNGAEANCTSGLCCRENNLASPTPGQISFPAPRFGAYLCDSPFSLVAAALQSIPVLTGTEKTGFDFTVYTGDLVSHDSEHQLSRDYVLYTETVIYDLFKRMLGTGPVYAALGNHDSAQDAPHALGGQQADQFSWNYDHVSSLWEYEGWIPKAAVDLARAHYAAYMVRRKDGLRVITLNTDLWYTANYFNYINMSNPDVSGMLRFLTDELQAAEDTGDAVWIMGHVLTGWDGSNPLLNPTNLFYQIVDRFSPHVIKAVFWGHTHEDQTIIYYANNATVISAETAGAVAWIGPSITPLTNLNSGFRVYEVDSATFEILDAHTWKSDVNSFSQLDSQTQFGPTYEYEYSTRDAYGMNIAGWGPNDPLNATWWHHVTEAMSANNTLVSVFNTFQGKGSVRSPACTGDCIEAKICYIRSGSAPIAKQNCILGFGSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDZ8</accession>
    <name>A0A2G8SDZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polysaccharide lyase family 8 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06698</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDZ8"/>
    <dbReference type="OrthoDB" id="5980780at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="entry name" value="Polysaccharide lyase family 8-like, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481:SF1">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="Hyaluronate lyase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013943388" description="Polysaccharide lyase family 8 central domain-containing protein" evidence="4">
        <location>
            <begin position="30"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 8 N-terminal alpha-helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 central" evidence="5">
        <location>
            <begin position="414"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="85167" checksum="19B1A01754DAEE67" modified="2018-01-31" version="1">MSRTRHGRVSRMLLPAVFTALALANWAAASVIPIRPSISNSGVSVVQVDEVDVDIVEDIEVIVERRIDIIVGGTTGASSISTLLGNLQADGTWPDVDYTAGCDAPTANWKAEEHWSRILTLASAFHGGLENADQFVGSSQVRSALSSAMGFWFSNDFSNVACLDFGGDASCACGTLGLWNRNWFSNIIGVPTFVAEVCLLLEDSLSASELASCTTIAERSFATFENGINGVSAITGANLQAIASIGIDHALLIKDSSILTDAFNRVHSDIVIQNALRADGIRADGSFGQHSGIIYNGNYGRDFESEILDFEIEVIETEFEASVDVQEVVEVLFEADQWMIFRNIFTDTLHWDFGVLGRFLTDPVADNHASSGVKTNLTQVQNLGNVWNSSTLQSVYANLTMNTTSANSGNLTGNRVFYSNDYAVQRGDGYVTSLRMYSNRTQNTECTDGANNLGFHLADGAVYQHINGDEYEDIVAAWDWNLIPGITVDYGATPLSCDQTRQTGIDPFVGGASDGRVGAVAMRFENPLTRNLNFRKSWFFLEEDVQVVIISEIVSVTEVEVFSVLDQRRAFGDVFVDGNTSTGGNFSNPSTLWHGGVGYKFNSGNATTLSVNVANRHGDWSVIGSSSQAPIDVDIFTAFLIHEDISVDVSFLVFPGTTVETFETRISETQVEVIESDSSVAVVLDVVHETVFSVFWESDGGEFIIPPLTQGGAPIHVQSSGSSNIIVHTDTWTVIVADPTQLLTELTLTFTADLEVGTAPTGWGSSASKSLQFALPTGGLAGSSLSQALFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEG9</accession>
    <name>A0A2G8SEG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06866</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEG9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEG9"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013762234" description="Alpha-galactosidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL32160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="432" mass="47147" checksum="65BF146B41D19533" modified="2018-01-31" version="1">MAPKLVALLSVLPAALALNNGLAITPQMGWNTWNHFGCGIDQDTIVSAAQALISNGLDKLGYNYVLVDDCWQADARDPSTGAPVEDKSKFPNGIKAVADQVHSLGLKFGIYSSAGTYTCGGKFGSLGYEDIDAQTYASWGVDYLKYDNCYNEGRAGTPQISYERFNNMSQALNATGRPILYSMCNWGEDGPWNFAVNIANSWRISGDIYDNFDRYDDRCPCTSMLDCKLPGFICAMSRIIDFSAPLGQKAGKGHWNDLDMLEIGNGGMTYDEYVTHFSMWALVKSPLILGNDITNMSNETKEIITNDAIIAVNQDSGGSAASRIWKRALPEGGDIQLWAGSLVNYHFVFAVMNTSPKNQTIDISLLDVFNDQGKVFGSGTFTISDLWQKDSSGNWGTTVGNFQGKMTVSVKTHATRVFMAVPASMAAVRQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SET3</accession>
    <name>A0A2G8SET3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05452</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SET3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SET3"/>
    <dbReference type="OrthoDB" id="2756378at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="177"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="373" mass="40982" checksum="74D2FB019C3FEC3E" modified="2018-01-31" version="1">MSSNPSSSPLAALPQISIDKSFGSVLIATFIGIALYGVVLNQVYRYSRMYTADRIELKITVYATVILETVHIALSCHTCYYYLVTSYFNPFLLMYPTRPMQLLPTFTSLVIVTAQGFFARRAYLFGKRYRIWVLIAVVALICELGFCIATTAEDQSGNFDDFVSTTWLLACGSGCAAGADIILTTVLIVALRKSRSGVKRTDSTVDVLVLYTITTGLITRRHNHAVVVPRSVYTVFGYFSIYKSGWLTVDLLEQLVIIPGEVGIYTSISIVATKLYANTLLAALNRRKSLKDRADLHMMGTDFVFGTEIREGARAHNSLPVAIEFHTITHSDASTSAGTASNKDNISHPSASIEKLGNGNQPHDLQADVMNIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF39</accession>
    <name>A0A2G8SF39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycopeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF39"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF39"/>
    <dbReference type="OrthoDB" id="3342934at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013668106" description="Glycopeptide" evidence="1">
        <location>
            <begin position="19"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15418" checksum="4867A02D98EDBB36" modified="2018-01-31" version="1">MQFSLSTAFVALAGLVSAVVGETHTVHFDNRCGHGTPKLVQGGKVLSSGEDFTIHGPLVSAIAYLQTGDCGLNGENCTLIQTTLQNGGSGSDTDISLVSPHKFSVTSGFGYYGGCDGAGADCKDQECPEQYHPVPCSADNVNLAITFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF87</accession>
    <name>A0A2G8SF87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF87"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF87"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF105">
        <property type="entry name" value="COPPER RADICAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013715134" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="150"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="275"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="387"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1003" mass="106163" checksum="65F643CD5B445B93" modified="2018-01-31" version="1">MPKMVALTASLAVLALSLPRISHASTLRVRQSPSTPAIPGTAFKFLGCFTDQGARSLGGATFTNTTGMTVESCIAFCSAQSFNFAGLEFAQECWCGNEIANGGTNATLSDCNSPCTGDASEICGAGNRLSVYWNGVQPPPPPTVVPSVGLWESLGCYNDSVNARALPTGVNVPGNFTVEGCTEACFEADFPLAGMEFADQCFCSTAIANGGAPIAASLCNMACAGNSTELCGGPNALNVYNFTGTITGTPGVPPGGGPGTGPVLVNPVTSGLPNNFTYAACYVDNANGRIMGTQNPDDQGLTVESCVTSCHSQNFTLAGMEFGVQCFCGNTLIDGATVGDESTCNMACGGNSQEACGGPNRLSVYTSSGSVVALPVPTPKNSSLPGQWEYQGCLQEGPNGARLFPNEIVQQTNNTVEFCLNQCAAFGYPAAGLEFGQECYCGDVSDIAQSPGFAPESDCNIPCPGDPIHLCGGGDRLQYYTWNGVMNDWKTPANTGRYEFLVPGVVVPLLVTLGINNKVSFVEKFGTSEFPNSTGAYELDLSLVDDFEKTWRTMHVKSDVFCSGAVVLPDRSARHLMFGGWSLDSTFGVRLYAPDGSPGVNGTNDWEENFDELHLQRGRWYPSGLVMPNGSVLIVGGEVGSNGAPEPTLEILPTPQGGPTYLFMDWLNRTDPNNLYPFLHVLPSGNIFVGYYNEARILNPATFDTIKTLPNMPGSVINPFDGKAGGRTYPLEGTAVLFPQHAPYTDPLTVLVCGGSNFGLALDNCVSIQPEVDGADWVLEPIASSHDVHALPDGTFLLVNGAKQGVAGFGLATDPNLQALLYDPTQAVGSRISILNETIVARLYHSESTLLPDGRVLISGSDPQSPQFPEEMRVEVYIPPYLTDGRKQPSFTVDQKDWTYGGSYTIHVQLFQGTTSTMRVSLIAGNAMGMRTLFPEFSCNGNTCTVVAPPNVFVAPPGWFSLWVLDGPTPSHLNWVRIGGDPGELGNWPDFPDFTLPGMGPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFH8</accession>
    <name>A0A2G8SFH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_05219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFH8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFH8"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="50"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL32516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="490" mass="53556" checksum="DF8B01973E9EA48A" modified="2018-01-31" version="1">MSDAKAADATSSSYPSSTKSAGALEDARAELDQFDPELVKRTWRKVDWAILPIAVILYLAAYIDRANIGNAKVLGLATSLKLTSSQYNWALSIFFIGYVIFETPSNILLRKISPRWYIPTLTVLWGLVCVLFATVKSAKGLLAIRFFLGVAEAGFLPGIVYWLSCWYPRTLLGRRYAVLYSTVSLTGAFGGLLATAIHSLDGTYGIAGWKAASQADSASSPSSSCPPTQAPRASSPPEKHVVLLANEADRGQRADERFRGAQVRAAFADWRTWLWGLVYIAIYIPVYSVILSLPSVVTGLGYAGTHATLMACPPYGLGFVIVLLAGWTTDRYGRLFCHFVGAIVVVMVALVVLMAVENLVVRYVMFFFVMFMFIPVSVCWTWLGSNVTSATKRAAALGVVFSLGNIGGTVSGQIYRAEWAPRYVQGHAINIGCYAIALVAGGALWWSYKTDNERRDGAANETVKKTKQHDLLGEDLGDLGDRHPSFRYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFL5</accession>
    <name>A0A2G8SFL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_05234</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFL5"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL32531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="599" mass="65230" checksum="980AE59118FF7370" modified="2018-01-31" version="1">MQFFASLVRSVYAATILATTGYAPSFSGDTKHNAVGAAKAIESFHPESSFETFDVNGIDHPLSDRPEFSLEDAAVSFVQSRLNITSDAVAFRTGYANDVIQHAYIHQQINGITVANAVANVAFNKKNRVVSFGSSFVQPSSVPSNTPSISVTDAIAKAESQLAGEYNGHPTTLEFVAKEDGSVALAHVVQIQDDDQDMWVEAFVDAHTGDIVHLTDFGAHASASPVYRALPLREQNVTQGFRTIKNPQNKAASPIGWHNNGVTKTNNTSGNNVITYVRGKGGARYTTPQSSAPLIFNYMQDPTKNPNATRANVHAARVNAFYVVNTMHDIFYLYGFTERASNFQNTNFGKGGWGNDRVEVSVQDTRGKNNAFFYTPPDGQHGYMKVYLFNRSVPMRDGALENDLVVHETTHGITNRMTGGGTARCLQTLESKGLGEGWSDAVAEWTEWTNATITDWVFCPYLKRGGFRIYPYSTNSTTDPLKYSSLKTLTEEHRIGAVWGNILHNVYAALVSKHGFSATAKTDPKTKGGNTVFLHLLIDALALQPCNPTFPQARAAWIQADANRYGGANKCTLWKAFASRGLGIGAANRVDSKKVPAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFN9</accession>
    <name>A0A2G8SFN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFN9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFN9"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="694"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="110"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="739" mass="81197" checksum="29D5937A26448D0D" modified="2018-01-31" version="1">MSDHGRGDWGSLAVRRTEDTEDGVCDLNVPTLLPREDDASILQIYAGNAFNAVIMPVWDSIKPDRIPTYPGWGESLYNIFIRSWYNIVCILVPLALAWVAKFEVLDWGELVTFVLCFIAMIPLQKTLDWGAEQMGLFLGKELSDLLVITLSNAIEAALAVILLFKCELRLLQSTIVGVVLLHLLLIPGVAFFVQGTQVYEQKLSPQFNLNHSLLMTGLLGILVPTIFFAALDRGSVAAGSGDQSGLTANFVPLVSDSVRWDILRMSRGISIMLILIYVTSCLYRNQVLPAHHAHALPLHEGDVIGQLVIQSPPHSRTPSLSRQPRRTMTSSPILLTRTISQPDTSPRALRSMTSPAAPLTANEHEERRADVNPWVCMILLVVAVGFMGATAEFLVSSIEVVLNTTHLPDEWFGLILLPNISFSADGFVVTVNFLLALVRHLYRKVRKPKSRKSRKARLHPRKLADRQHPSLYDPKCSEPKLSPTEDQDVLHTGFVSDPEAMDPVLPHPHQRARSDEVIGANHTRGASTTTALAHRPPAITVRSPTASSVAPTGSRSATNDTGQCGDGGADIDAEAEDEKKFEHVDADVESARPVDALDEDGDEDEDSDGAGGGWSIFNVVPEMPWASEFAHGRPIDLSIQFTLWWMPFLVLLGWWTDRPMHLLFDYFEIGMLLGACFLVNWVTSDAKTNMSEGLTMITFYAMIATAAWWYPGQPQVAFMLNCPGSVAEAVAAAGNATSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFP1</accession>
    <name>A0A2G8SFP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFP1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="109" mass="12548" checksum="4BC347D55C8B9563" modified="2018-01-31" version="1">MYTLPLARIPENLHWVPRARRDVLGLHLQCVTWTMTGRLSDVVVYEEYAHNFEWFAVEPLEGDAREGLARVRQHLEAPHLVDLDEPLYAVALPNCSNKCHTKETSSKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFQ2</accession>
    <name>A0A2G8SFQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFQ2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="116" mass="12139" checksum="7112F476ED5C19A0" modified="2018-01-31" version="1">MGMQLLERSSSPVRSVCTGACPGAAPAFMTLKHEYAWRAARDMNVTVGSMCRRTRGPEELSPRPIPESGEVGEPGVGTKLAMADEVAAVGERGDEGMEESEGRRGGGVPGSGRTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFV0</accession>
    <name>A0A2G8SFV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFV0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFV0"/>
    <dbReference type="OrthoDB" id="3067110at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="351" mass="38768" checksum="C0829EA0B12A9CE4" modified="2018-01-31" version="1">MDAPCAHIDASVSKAISTLRPISLTGLFGGDTAVAAMGTVHLFAHRWICRWYNTPGSYEIAKRYGQLANVWFWDGLFPGGTHDPSELFKLNGMKGPPFLGRALERPSSILVACCSFLLLGQFVTQLLIIPLGTPPGQVLYIFSLAASWLYNAYLASHNREDIQTEILFKMLRVEEGRICKVRCDFRTPMAVFTALVLQGHSRAADPKPSASSTSSAPSPDPSPDDVPYLLPYSDKHLQVENGRTLRIALQNPTKILNGIIPNDTKVWTDWKKHVGKAITRTLYPDQGGPLNPAAGWSDIPSTSSGAETASGTRPSPVEEEERLIRRLYGYANDGQRMYHAWLEWCASRTHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFV2</accession>
    <name>A0A2G8SFV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFV2"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="282" mass="31237" checksum="E3B4E807C065E0B0" modified="2018-01-31" version="1">MDHFPTNWGRPRNDAFDPYGTYPIHQRPATKDNFAEGVQRTQQPIVTGTSVLAIQYKDGIMMAADNLGSPPPFLPLTQSDRILSAASYGSLARFKDIQRLHQVGNSTVIGASGDMSDFQAIQSLLDEVVIDEFTQGDGHDLGPAEVHEYLSRVMYSRRSKIDPLWNSILVGGFRDGKRFLGYIDLLGTTYSSPSIATGYGAYIAIPILRSAVDGRVDELTEENARNLLHECMRVLFYRDARSLDKYQIATVNASGVHISDQVHLDTSWSFAEGIRGYGAQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFX7</accession>
    <name>A0A2G8SFX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFX7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFX7"/>
    <dbReference type="OrthoDB" id="2757183at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8443" checksum="0F831A48FBC76CB6" modified="2018-01-31" version="1">MPVQRIGAPADADVRTPEGPAELAPQVRTYGFMCIVNHGLTEAQNDRMVDIADVPFSEVPEDEQHQLLSKVRELGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFY3</accession>
    <name>A0A2G8SFY3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFY3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFY3"/>
    <dbReference type="OrthoDB" id="3095879at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="437"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62424" checksum="79CBA8BFC39F56AB" modified="2018-01-31" version="1">MFFGLANSPSTFSALMNDIFKDLIILGKVTTYLNNILIFTNDIEEHRTLVREVLKRLAEHDLFCKPEKCEFEQPKVEYLENTSDVQKFRGFVNFYRRFIKDFSAICKPLDRLTGNAPWKWEAEEQEAFDELKRRFTKSPVLSMYNPDCKTRIEVDASGYATGAVLSQEGEDGKWHPVAFHSESMSDAEHNYEIYDKEMLAIIRALQAWRHYLEGLPSVFEIQSDHKNLEYWKTAQNLTRRQARWALYLSRFEFVILHKPGTSNGRADALSRRPNHQTDDADDNLDRVLLQPDRFRVLAAKRGHMSVVPEKALLRRICECGEREQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGQVYVPKDDALRAEIVRIHHDLPPAGHPGQAKTVELVTRNYWWLGMVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNALQLIADRHGKIIHLIPCTEEIDAEGTADNFIREWFCLHGLPRKIVSDHGPQFSSKLFRAVLKGLGIESAMSTAYHPQTDGQSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGB9</accession>
    <name>A0A2G8SGB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGB9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="144" mass="15130" checksum="C941087E21674CCF" modified="2018-01-31" version="1">MDDMSAVINGRSGGLEAWLPSQGQSWGMSDIHEGEAAWVQVDVFAVLGGVRDEVELSELVMTGETARKDLCTDRTVARCRAMWALAECALRLDMFALHWISTGILRWTAAGTCSVCACAKAASRGALAVAGNMAKAVAVVALGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGU7</accession>
    <name>A0A2G8SGU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGU7"/>
    <dbReference type="OrthoDB" id="2757906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="264" mass="29714" checksum="CD8DD5CE776D0C5B" modified="2018-01-31" version="1">MVHGLPNLKKLTCYSVHWIAPGGSHPEADFTKQPKWAAGKDTLPSFAPKLLELELSNIAMYGAKQLIWTRGPHLTWLALAIPVLSDLEEPADGSVIDLGSCTGLETLNLLLTSQFSINTHARFVTELLASWKPLHLNPVLQLSPECQSDTTRQDFAEALRGLGTITEAWLQTLEEPPPSGEIQDHQQVKYRLEVYMHESEAEIMWWLDHLESCFPTWMKLGRIELGMSMPRDEWADEEKSPRSEAVDLSEVEEVESDSLSKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH08</accession>
    <name>A0A2G8SH08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine kinase/Phosphomethylpyrimidine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH08"/>
    <dbReference type="STRING" id="1077348.A0A2G8SH08"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="1">
        <location>
            <begin position="243"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="291" mass="30441" checksum="31603B70C0C4E059" modified="2018-01-31" version="1">MDRKAPPAVLTIAGSDSSGGAGIQADLKAFMAFGCYGASVITALTAQNTKGVQGVHPAPPEFLEQQLKSVLDDIEIKAIKTGMLYDAEHTRRIAHTLKAHFTGGRPLPPLVVDPVSVSTSGHTLLHPGAVDVMVRELFPLATLVTPNTPETELLLSRIADVTESDSGPTTIATLEGMLAASEKLRTLGPKAVLIKGGHISATFADVRRVSAARPEVVLVLESFLDDNMEILQVNEADLGASPLVVDVLRESTGAVTLFVSPRIESTSTHGTGCTLAAAIASLLGKGESSMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHC6</accession>
    <name>A0A2G8SHC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHC6"/>
    <dbReference type="OrthoDB" id="2756427at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="47181" checksum="BD4A36378BA02E2C" modified="2018-01-31" version="1">MDLLTWYDRVSGGASFLVSMPARPGTLPTITAVNMDVFLPIIPQEQPKTSIVFARMVQSFAEEIGLPTIRRMNKAKSTTAQRLPIVVANTGSSVDIQPLIPPSETPWHRFYGRDVGVLERLIAEQFPDVSAVQKLPSMILRPQALLPPLAPKGSAPHATVGSSGLQKQVPWTAGDILHLAEQFGRCNERDEAGLRAIAEQVSTRLPDIFKVITDLELRVEALETVKQTQLEEIGSLRQALQESFDQHRGELIRINEELSAPSVPELPRPSLTSVRSGRIRALATSNSILPVSSIIDSAPPPSIHNARYEERKTVPIHAATSPPRSASAPNNSNRPSGSRSGSPNVSLNVLQVEEKWSKGRIYGPNTEQVLQRHKLPRRVHTILRNLEKTRSQENLMQAVRATVPNCSQDLARELVDAMKNDRDLSSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI20</accession>
    <name>A0A2G8SI20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SI20"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1355"/>
            <end position="1371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1436" mass="161099" checksum="2F024EF6171C6DF4" modified="2018-01-31" version="1">MAPDNPQTGSSTGRKGTAVSSDVDDAKRALDVASARNLKTRKPEGKETQQAGPDLAAATKVVDTVSNNDGVNLLFQGVNSLVDSLPPLVKALEAVAQIHPFVAIAVGAFKVVIELEIKRRDNDKKVNLLFLEMRNMMSVLLQLQSVRANHVARDGITIGARLVDLVKRTANDIKECANVCDTYSKKRLLVKVLKGPIWDDTLKGFIQLFVDRKAEFNFAVSIHTGMAIDRANDKLDALTARMELILKFFERSIPFSQRSLNALVEQAGGPDAALQSPNVLQKLIERESSFERIPDLAGDDRVPYFRAPARTPSAVGIAGSSRYRSHSGFDYSRAAESQRSRRRTRSHASTAESHRASAPRSYIPNSYASGLAPAYPGDQNPPLYGYRKSYIDDVQKSPHEQDIAMLKQELAQAPSAEISKNFETFERKFEIQTRELAEEMKRLIVHEGDRVISSVLAGPHERIIDPDLYEIWKDMRWRGIVKARHLVLAIHDYYLQKQEDQGQVFQVDGTQKRGSIYEDDSWTFEYIDLMHVQPIIEGLDDDASGFVTIQEVNQFTTSRPKGWSLLHWMAYWAVGWRVCMTAYRRKMLSTLEFMTSLLETVRVPNRVKLVEYLSLTRNVILDIVQPFHEDTEQLFVLPRFQAYMDHNEARLRKVLETVKYQIDALDTLALINGRKGLERNVFPLLHLVLSRHYDIMKLGRIHILHPDELIEAQESINIIQDAFKLRRNELSALFQQRRLSVSQEFDDFAFGMFSSASGYMPEVNARNSEGDETCSPDEELKPPSTGILQYPVHHEDFYPVNEDDVHDDEIGKDVDDSLKPILGRWSGTVDAVDGSIGMPLLNIYFHPASSSKNQVIAAPKLYFPWLCTRAIIVGECCSTSAGDSIFTFTTTFNSASCQTEYLRMTLSPDGKTLVGYQDIVPDCSSSGRFHVVMKKDIPLEVMAFYPSPQLLDTNRPKALWHFATSAILFQVQQRTITWRRIKAHRDKRRRYASLVYLQSTREQLQPADYEELQRLSNRSTLAEVHCCVYTAVEPEKFPWILPPCSGGTCGLLMKTAVPMLRCLFCPPELGYERFGAVFCGDTPDCLGDHLRAGLFGMHCIVKTRMVGWSAGDNEDERGRKASNLLSLVTATIGLLEGSRYGPPMEEHFSPHRLSPITEMSDEDQTEYGEPFLASVGTPNAVDNLSVSPVLKDAQHPDWQPESDLRSLAGEPTTPTHGSQLVDATFSPGSRSDTTVVEDGVMGEYPLLDSTEHSVQLVADRGRICIDCKEEVKMPCWLCTDCPGMFAPGDYNIGAFVSYYIHTLSGNIFVCLICDEKGGITAGNHEDTHTLVRIYVNQTGHASARKARHRQVSDYNDADEDYEDEENDDASESDWNNSRIEGAIESQLIALGGRLTRMEERFGTIESKLGRLEDMLGTVLSLLRAQPSTDNVRSTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI46</accession>
    <name>A0A2G8SI46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI46"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="543" mass="62001" checksum="918A444055533F9A" modified="2018-01-31" version="1">MFGSPTIRSTTCNSHQRRKPTCQGKEYSTRLKIAFPDTEFTFLPFAPNDVEDNSARTLPRFRVDLPLMCESANQDPFDDNLPTGAPRDRQRRAAFDQVFAQVEHILHHQYRTFLFMVIFVGLSARLVRFDRSSVFVTRLFDITGSDVLIDFLGRYTHLFPEDRGYDTTARYIDPAARDPCSLAEKMRRCLQDAKARKDEDYIIEMWDVSLDERWPWWKLRYLKDTWRAVVTDPLDEASYIRKEGATLHDLNVAKTNNVPTLVCHGDLLGQHTRAPATWAERLPGFKPLSQTYQHYRLVVQEAGKPLSELENSGDLVTALYDCIEAHRGTMKVGIIHWNISLGSIILYNKTDRWHGLLTNWELAKDCSLAVRLEMAPGRIGNKRFALSFFHVMIYCAVCFLKHNIPDEFVGSFLHNYFHISSGCTQTGEFAASALKRNSMVSGTISLLGFGTGNYYLRFDWRSPLLLFPYVHNSFGSPGQIEFSSLAHLSPGYLKTLYGLSANLDHHSHVMQLIRLVGHKPFPLDKVDDKQPVCEFCLANSGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIB3</accession>
    <name>A0A2G8SIB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIB3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIB3"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="405" mass="45456" checksum="08287A96AD935B96" modified="2018-01-31" version="1">MSSSKKIGGEYGDIRANIDNDKLNAYLVAHVPAVAAPVDIKQFKFGQSNPTYFLTDARYVARILVRKHADPERSKKRFVLRKKPAGQLLSKTAHQVEREYTMLRALHKHNTNSATPRDKRVPIPEPIVLCEDVSVLGTPFYIMEFLDGRIFTNPRMPEVSPETRRECWLSAARVLGTLSLLDPAVIGLSGFASNTPYFPRQIKSLTAVSQAQAQAVDVETGKQTGEIPRFADMIAWYKSNLPDERKTGLRIVHGDYKLDNLIFHPTENRVIGILDWELCTLGSPLADLANFTQPWAVATDSFPDGVNVSAAFKNNAKEAPIAREELEQEYCRVTNQPYPIPEMVFAQSWMLFRSAVIMQGIAARYARRQASSERAFMYVVGFPYMGHLAYRTLEEAGVTGSRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIM5</accession>
    <name>A0A2G8SIM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIM5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIM5"/>
    <dbReference type="OrthoDB" id="2745837at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="325"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="794" mass="88576" checksum="79C8D4903D53B3F5" modified="2018-01-31" version="1">MTLVSINTPSSPTKALRQNSAATRKFTRQDARAELRSTMRRKATIVTLEEMMKDFLTPLAKGSKAIPNVFTKVPKFGSEKQMYEYITKTLNESDQFSRVGMTFVTTGYKPDKNDDSKQTIDCGMYAAKLAPQEEYTESGEESRRMVWALIELLIECKLDGVGQDPFDDSTEGGEVTAEKRREVLGQILSYVELAFKYQQREAVFMVLFLGKYARVVRFDRSGIIASEKVDYKKDGEGLTEFLVRYARLGLAKRGHDPTAFRISPADPLGEKLKEHGAAAAEKDPEDHVQKLFNQSLDEKWPWWKLYVHDEESDKTKWFAVGKPHFYAGGVAGRGTRGYVAVPLDDDGEKIDSKAAFVYLKDAWRVDHEGMEMEGTILKALNAAKVPYVPTLLYHGDLDQSTLSYDRWTDYHEGKTRETCSLKSHQHYRLVVAEVGKPLSEFENSIELVWALVCCITAHEQACAAGYIHRDISAGNILLYRDATGHWAGLLNDWELSKEWKGGKTQGGGRQLDRTGTWQFMSVHALVKKHRPIEIPDDLESFFHVLVYFAIRFLPHNLADNLVGHFLYTYFDDYSDGAPGFTCGQLKYNAIKRGLIDITLITGSGDATESDKEEPLVFFQPQSASPDDNDETTEDVAARASHPIDDLISDILKALQAFYAKDAAKKPKRRALGNTAPGKLPPSAIAAIEAELDQSEDDSEEDDGAESSSPKAVPTSVSRLAAKVETHAAMRKLILSHLRREGWPDVDRGDDKKPKGGYVPAKENTLVGSVIPTGSKRGAQDDGESTSKRVRSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJS3</accession>
    <name>A0A2G8SJS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJS3"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF82">
        <property type="entry name" value="NIPA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="464" mass="50115" checksum="5E8CBF373B665803" modified="2018-01-31" version="1">MRAEYVAPLGSTSLIFNFLFAKFLVNTPVTWNDIYGTIIVIIGVIGIVAFGSINSGFASETDAHHLTELWTRGNWLAYFFFMSFALILLYIFTAQLDQVLAARSDLTAEPFAGMRSRAGGLVTPPTLGGRVVAFWDNAMMWTREKLELWTASHDDKRIAWTLGIGWACCGGGLAGATLVFAKAAVKLISGAMSHENTGNQFGHASVIFTFIFLAVTAVCQIICLNKGLAVYDSTLVVPVFYGVYTGLGFLNSLIFNDEVDAYQSWALFLIFCAMIILVSGVVLLTYKKPEPKGSTPQSGTPLSGRGHRSATKGTFVSSGRDEEEALHEGGDIENDDATMWQLGEASDDEDEAGGVPSRSPRSPRMQPASPRVQRKVSGISLKPAAGQSQINLPRGRVRSQGEDEEASMLADQDDADDDEGDDPHRRPSSSSDSDATLARPDTTPYMDDDAFGAWEASPPAKAHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK31</accession>
    <name>A0A2G8SK31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">fumarate reductase (NADH)</fullName>
            <ecNumber evidence="10">1.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">NADH-dependent fumarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_03836</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK31"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK31"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF1">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="514"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="482"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="483"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL34125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="591" mass="62907" checksum="4615FDF398E1F369" modified="2018-01-31" version="1">MAQVIVVGGGLAGLSAAHTLLERGANVLLLDKQPFMGGNSTKATSGINGAGTQTQQELGIPDSAKIFFDDTKRSARELARDDLIRVLTGQSGDAVNWLQDKFALDLSKVARLGGHSQPRTHRGNAQFPGMVITYAQMERLEDLAESTPDRVQIKKKARVTGLIKDETGAVVGANYEHQGKSHAAYGPVILATGGYAADFTADSLLKKYRPEYWDLPTTNGEHCTGDGQKMALAIGASAIDLEKVQVHPTGLVDPNEPEAKVKFLAAEALRGVGGLLLDNTGSRFVDELQHRDYVTGKMWENGKFPIRLVLNGAASKEIEWHCKHYVGRGLMKRYESGEALAKDMGISTATLKKTFDDYNTVARTKKDPFGKKFFADSEWKLNDYFNVALMTPVLHYTMGGLEIDPESRVVDKSGKPIPGLFAAGEVAGGVHGANRLGGSSLLGCVVFGRVSGASAASYLLQKIGPLAEKAAGRLGVVAGHLGSETSSSKPATAAASEEKSTSAGAKSSPASSSGGAYSAEEVAKHNKKDDCWVIIDGKVLDVTGFLPDHPGGEKAILLYAGRDATEEFNMLHDAKVIPRYAPEAVIGSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK81</accession>
    <name>A0A2G8SK81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK81"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK81"/>
    <dbReference type="OrthoDB" id="3238622at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="300" mass="33837" checksum="B6C0591E4AE27142" modified="2018-01-31" version="1">MQAAETSDSLTTSSPRSEFHHLFASPEGDIVLGSKDGVLFRVHSYTLKTTSGWFRAMYSLPQRTPDSRPELKAADNTPDVVYVDEDSRTLEGLLRMVCGLSIPNLDSYDIIEPILHAAEKYDMPGPMSIIRALLSTPPLMSDPLRLYAVTCRYGWQDEAMMASRATLTLNIHSPEHRNTLQKLGSDALLSLFSLHRTRREALRKRLDDPPFVNDSGDTSCSNCGSLVDYHTWRELKYVIIMEMDARPLGDTVCNTGLLEWSAARACWEAKCINCDRVLYDKTLTMRVIRECIEQLPTTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKD3</accession>
    <name>A0A2G8SKD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKD3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKD3"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="544"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="654" mass="73632" checksum="23A9669BA589A875" modified="2018-01-31" version="1">MATAAPLPRNPLATRPQQHNTGMSISPCRTTLKKASVALKRPLSPEPADTPTDHSSKRVKTTLSAPVIQESPTPAAAARMEAKKDKERRREKERVQREEEFKVKYSRAFPSWVFYFDLDSGNPETASIRNHLEKRVGFMGARIDDFFSKDITHFITLHDVDDKENKEKETSRAGSASAAAAATGGGLLASPIKLRGRALATNTKMETLVQKAQSFNMKIWSATKLHNILDRCDAPRVSASGHLPTAAQRASKEHNLAHLLKTERLHGTTSERDPSQRRHDFSYFSKESYFVLVEDLKQELATISVAEYQIQKTRDGKEKGAWPVLHCHPKARGPFLEYDDREERRRQKQEKAELDRREERARRKARLVQHERKRRAQEVRMRAQQHQHDLRRTASMTNLQRRATYPDASLQAPGKGLVDLDADFPEESHVEGESVHASGYLASAAYMAASGNSVRVASTTGTSAAGDLLRSLAVTSALKDKLAQQITMNRRASAAASTTTGTAPPTDRENKENVMGPPAMIPDRAKFVRKSKSMSTLKLPKREEGSKPGYCECCRQKFENFREHIITRRHRKFAADDNNFKALDAILSRVRRRTVEEVAEEEERWLAEARGDVDAHADEDDEELLQPKLEDASDDDVRWDEWVAMDAVKVEACA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKE5</accession>
    <name>A0A2G8SKE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKE5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKE5"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="665" mass="75310" checksum="B070970EE333ECCA" modified="2018-01-31" version="1">MPQVSRSPKRKRVRRYFSASAATGVRWNPKTHAVAGSSTASKTRKRGSSVSSDETYGFSPDQAQDEILSEEDTTFRYSTIERSFPPHDDQPESPDGPRQPLTYASLPPTPITSSPPLQPTSPEPVPLPAFQSLDSAYEPPFSLWDYLREELLATDFDSHQELKWERVSNFLSMPIALEKMFLFGFMVCLDSFMYTFTILPIRFALACWRLLLNTFSRSSLPLPPSQKADILRALLLVVSIVILAPLTDASKLYHFIRGQDTIKLYVIFNALEIADRLCASIGQDLIDCLFSRSTLEVISHRKRPTSHTLRPFFYFLLAVVYTVAHALVMIYQMISLNVAVNSYDNALLTLLVSNQFVEIKGSVFKKFEKDNLFQITCADIVERFTLALMLLVVAFRNLIELSGSTFNFSEGFALPKSFGWFRGNNVLWTISYPVLTVMASETLVDWLKHAFITKFNHIRPSVYERYTDVLCRDLASASAVGRHGVRKHSYVDQSPLVARRLGFASLPLAVLAVLIGSQSVSLLVSMHADESPLWTKPWEAYTQDDWINIVKWGALGFLCWGCFVVIKIILGVHLLTYATRRRAGMEAREQADHINDFGRDPIGEGKEEQRYNKELKTLLDNKRDDASPAAEMGERKPGDGDKDGGKRKRLPLEEITRFTMVKRIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKJ1</accession>
    <name>A0A2G8SKJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspergillopepsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKJ1"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013694845" description="Aspergillopepsin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="28605" checksum="D81CD09237BE7FB5" modified="2018-01-31" version="1">MFAATLLCQALLATAAFAIPTSKERFAQRIARRAGGFNHQSYPKQGIEAAHVDLEVNAHRNASQTSYSSNWAGAVLSKSTATYKSVTGTFVVPTPKEPSGGSGTHYASAWVGIDGDTCGSAILQTGVDFNINGNSVSYDAWYEWYPDYAHDFSGISFKAGDTVEVTVTATSKTAGKATITNKSTGKTVSHSFSGQPSLCEYDAEWIVEDFQNNGGLVPLANFGKVEFTNAKAGTQSGSVGPSGATLIDIKQSNKVYTSSSVGSSSVTVEYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLA7</accession>
    <name>A0A2G8SLA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLA7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLA7"/>
    <dbReference type="OrthoDB" id="2752753at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42977" checksum="702318A1A0157D2F" modified="2018-01-31" version="1">MGRWPSIRVLRLTHLVIPVKSAIFSTLRVLDLSHLQDSPKMRALPLDFALNALSGCHELQELKLNSVFPELVGESDYIVPLPQLRRLEVISKVGPTTRVPFPASPLVAMMILRYVELSPHASLRFVSHVKPSTQVGYRSFIPPEDPAYIPILSHATFAHLRPNSFTCSEPGGGTLEVAVEFDHEEEEPRQWFNQDLQLIDMASLLARAPITHLALTSASLYSESIAIAFRTFPGLTTLEFSTVPSSSCRPKDWRFPALFCCLIVPPEVHIRDAVEPADETDEEYRARLPLRRLRVLRFNALLWESTVLTLLFGTLYARCALGAPSLAELFVAMYGRAEAAEAEDADVREKEEKAMEMLESLVDGPVVCEDCEPPVSSSPGGSNFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLN3</accession>
    <name>A0A2G8SLN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLN3"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="16650" checksum="6B2BEA679147ABCA" modified="2018-01-31" version="1">MSYFLPHLPSGWHVDEAIKSEEDRVVVIRFGHDWDSQCMTMDETLYAVADKVQNFAVIYLVDITDVPDFNKMYELYDPCTVMFFYRNKHIMIDLGTGNNNKINWAMDNKQELIDIIETVYRGASKGRGLVVSPKDYSTRYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM22</accession>
    <name>A0A2G8SM22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM22"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="13813" checksum="63316A6FAD576145" modified="2018-01-31" version="1">MPFASPVLDICARTTSSVLAVFDQILEGVEHLHRMRISHGDLFEPNVVAATETDVKRDPRLTAGRVYLIDFESCQQFEHGPGEQPAVPLPNTHVKPPLGMKSFDPFSWDVYCLGRTLEYMVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMA7</accession>
    <name>A0A2G8SMA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMA7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMA7"/>
    <dbReference type="OrthoDB" id="2792702at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="128"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="209" mass="23083" checksum="066FA03C274A133C" modified="2018-01-31" version="1">MVPKVAFIFILDTLSLVLAVDAFYKFIVTDLFDPLLLLNVPRASAFENGVSVLLRTLTQWYVPPFGALYALSNRQQASLLIEFGALACAFSSFSLGIVVSLHMYTDSYIFSLATVNMRIIAGIDNGTSVICDIVIMVSLCYYLHSRRTGFRRTDSIINRLIVYAVNRGALTTICQGGEMVTMVVLPGRFMFVPFALVGGKLYCNTLFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMR2</accession>
    <name>A0A2G8SMR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMR2"/>
    <dbReference type="OrthoDB" id="2746427at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49810" checksum="C9671FD23E3876C8" modified="2018-01-31" version="1">MLKRDPPLYAFLHKLIVEHIPERASDGFDPNDLLEVLSRATYLRDLRIRWCDHLFTSESNKRLPETLPQLQDLRRLEIWTRRVSTDPLVADTVLRLRSQLRILQFSSDEDNQLPRDFPNSLAERQTSLHRLRICYPDLTSTPWVPFPSLRALYLTIANKLPSLPHLAQIFPNLRELAVFAVGFEVDFAHPAPEHVRVRQEALAFQKTGGGWKSLDVLTTTTIGDPWVLCLACPVGSVRLGNYDVSNHEAFVDVVSRTRPKKITLHLACATYCVKPMPNPSIFLFPGGDPSKDGGAGRQGATHAVLPFTIASFWEGQTTSAIIDVINSHISDSRIEYLHVALAEFFMFSPEIDERVLKPRDIHPRSVKVIEEIDVDLLVHEIAMAAAHLRVLVVTVATRDQSLWMIERRGEARVLIRVESLCSAREIIEREERAYLYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMU0</accession>
    <name>A0A2G8SMU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMU0"/>
    <dbReference type="OrthoDB" id="2746427at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="48750" checksum="76D477B76FAE75E6" modified="2018-01-31" version="1">MASDNFDPSALLQVLSRATYLTELRIHWPDKDILNLFVPAGGTCFAAIFRELRSLRRLQLGNVPPAAFKDLAAAVPNLTPHLRILEIISNHLEPIEFPHTLGAHLVHLSSLRIYYPDLTRPRWEPFRSVRHLFILWPESVPLSLHALASTFPSLRALYFGLGRPGRHVDPHAIPPSQEGVRAAALAFQASGDGWPRLSVLSTTTAAEAWMLGVACRVRALRLGVYDAARHATFVDVIARVRPTKVTIALEGAARCVQPQGALSVFHSSASSPEVVGHAAANGAVTHAVVFMVVPSTQAEEAQGAPGIAEIIGSHLRHSRLSYLHVVVPPDERLKGMIFMQDERHIYPYALRQHRQAQDQAQAVVDSDPSSHQEPSRFADIDIPLLVSSLATAGCRLRTIALTIAERGQSVWRIDRSVNRHAQMISRIMDPVLAKAVIAEEEHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNB3</accession>
    <name>A0A2G8SNB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNB3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNB3"/>
    <dbReference type="OrthoDB" id="2757214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013822646" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="48047" checksum="AF0E46BA9E6739DC" modified="2018-01-31" version="1">MTTMPALGEWLVYTFLTLTLSTRAAYGAAKSNTTCASTQLDWYTDAVGETPCVTYQRLRQICNSDYQVQKFNSLTPGDTCDDQLKDCCCNSVSFALSMLCMNCQYDSASDTSGIDAGDGAYEIYAGSCLKSAINQTLPDDVQSAVCNKRIKIDRNLYSLFWNTGAWFYKYTKDTITEDLAATNNNTFTHCASTTVNATTTKAGSGTATSSTKAQAHSTTASSKSQSSGSNTAAIVGGAVGGVFGAIALGLVGFCLWRKKRQGQGPKPLDLSGEYQYKSETQPGQFGAITPFSAPSTQDLSSRGGPESTFGASASEMGSGTGSGIASGSTPSTTALVGPGAASVISGRPSKFAGREGPSAYGFDEDFERHQDGGPATFLHRSASGRLPPAYQSWDEEPNDMSSAASMSQYQPHSVVGSSVGVDPYGAASVAGSTEPVVPPPPLPEPQQYPRDVKRPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNP2</accession>
    <name>A0A2G8SNP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02122</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNP2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNP2"/>
    <dbReference type="OrthoDB" id="5579860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="135" mass="15253" checksum="A7B438DD7D3245C2" modified="2018-01-31" version="1">MRLRCRSDPMGGGTFGRVYMALVTNEASLRPVALKKVHITNHVKHPPLLHEAAALLRLQDLYHWFIFRKKPLTSRNLTAIVWQLLDVLEYVHSQGIIHCDIKPTNILLGQGGTESHIFLVDFGLSLPFDSQNSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPT2</accession>
    <name>A0A2G8SPT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_02453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPT2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPT2"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="118" mass="12828" checksum="9E06B8456317F30F" modified="2018-01-31" version="1">MIQTGDPTGSGKGGQSIWSKPFSDEVRSTLKFNNRGILAMANSGPDTNKSQFFITYAKQPHLDGKYTIFGKVIDGADSTLEAMERVPVNAKNRPLNEIRTTHVTIHANPIADAQLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPY5</accession>
    <name>A0A2G8SPY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01495</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPY5"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000192">
        <property type="entry name" value="CTD small phosphatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="10">
        <location>
            <begin position="226"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL35835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="398" mass="43731" checksum="9C8DADBDD65CDBE2" modified="2018-01-31" version="1">MTGTAISIAEKSPVEDLRPPKEKDNSVTTFAAPVEESKPPAKRAKKSFLFKFTRLCKSCITAQQTHSIDLDEGQLPESEKQTLKDTETGQHGTHSSSSTVTVPNLPPLAIPAVVPDGEVEVIVPPTPTKQLLPLSETDGLTSGAVQPPGSTGENLNRPPTHYDKSHVHDASDDSDSSFSDEGEFNEAILINQAEDEEQRLIRSGGTGIPIDADGQPKPLLPPIAPQHVGRKCLVLDLDETLVHSSLKAVPSPDYIVPVEIEAYWHNFYVLKRPGVDDFLRRMGEIYEVVVFTASLSKYADPVLDRLDPYNSVAHRLFRESCYNHKGNYVKDLSQLGRPVKDTIILDNSPASYIFHPHNAVPVSSWFNDPHDTELTDLCPFLADLCHVDDVRGILNPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ55</accession>
    <name>A0A2G8SQ55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01554</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ55"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ55"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="168" mass="17741" checksum="EF5704BBF884AB75" modified="2018-01-31" version="1">MPVPSTKTDSIYPPPATPFDHPSPWVVLSDFGSAFAMGAVGGTIWHGIKGARNSPRGDRMVGAFSVIKARAPVTGGNFGVWGGMFSTFDCAVKGWRQKEDMWNAIISGFMTGGCLAARSGPKGALTSAVMCGILLSVFEGVGVLVSRVFNEGTRPQLPPLPENMQPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ63</accession>
    <name>A0A2G8SQ63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="2">2.4.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">UDP-glucose-glucosephosphate glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02438</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ63"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ63"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000007">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000035">
        <property type="entry name" value="Trehalose-6-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF106">
        <property type="entry name" value="BCDNA.GH08860"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="593" mass="66334" checksum="B3911E7E71D1FC7C" modified="2018-01-31" version="1">MSPAVVDSSLSAPDLAIPGDGEQRHLIVVSNRLPITINKDASGEYHFKMSSGGLVSALSGCKKSMSFTWIGWPGFFIPPKDRPLVDRRLQEEFSCQAVYLDDDIADRHYNGFSNSILWPLFHYHPGEMNFEDENWLAYRQANMAFAEAIMSQLKPDSMVWVQDYHLMLLPLLLRTLIDGPQTVGDLTATEVDRILEGVDCEEIVPPRYENVKIGFFLHTPFPSSEIYRILPVRREILLGILYSDLIGFHTYDYARHFLSSCTRILGLPTMPNGVEFEGRLAHVGTFPIGIDPSSFIDNLRKDAVKKRIAQLEQRFSGCKVIVGVDRLDYIKGVPQKLHALELFLSQHPEWIGKVVLAQLAVPSRQDVEEYQNLRATVNELVGRINGRFGTVDFMPIHFMHKSLPFDELCALYAVSDVCLVSSTRDGMNLVSYEYIACQQERQGVMILSEFAGAAQSLNGSIVVNPWDSQQVADAIFEAVTMDAETRAENHRKLFKYVNKYSAAYWGTSFVREMTRIELPNSAPKPVAESPAESTPDSPVKTNGALPRPTVKELKGGQAELHLKKDELRGSVLLENGIVPPTPVQNALAPHNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQA5</accession>
    <name>A0A2G8SQA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQA5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="331" mass="36590" checksum="7511FCEE2F702D9E" modified="2018-01-31" version="1">MFADTVIAEALATDLRRHSAEKLKVIPNFRDVSIGELRLERMNWCSTRDVMVKEIDAAPGVYPVVWSVKVKPRRPQQEPGASGAQAAAGHATNQSKAGRMIRSQPFEDFIRDEEASISLWTIPLDHACVPNSERCGEMPDPGEGGELEPQTTSHRSEHAPQDPQDIRISKAIRVALDFTMRDGRPMRRTGIVLLKGQKVAIQSNSRVPEDLSSMGWSVRWDNWQWFAGMQVSLIVPMPPSRPVGSGSGSPSDPIDVQDDESRFVVLAWKERMPNSNVEGNVGSDGSIVTMIFKKHDTTSGQSEPVEFTEEEKRAFGIGLSEGDEVRISTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQN3</accession>
    <name>A0A2G8SQN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="2">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQN3"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836175" description="AA9 family lytic polysaccharide monooxygenase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="4">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="244" mass="25588" checksum="B7111EDA8E3E4534" modified="2018-01-31" version="1">MFAAAALAALALGATQAAAHGGVLSYSINGQTYEGFKAYNSPTGQTSIQREWDTYNPLTDPTDSFLSCNTNGANLGSGQLSATVPAGSEVVAYWNQWPHTIGPVMVYMANCNGACTSATTSALEWFKIDEAGLISGDLPTGLWGQGELVADNSSWTTTIPASLAPGEYFIRHELLAIHTSDQPQFYPECAQLIITGSGTAQPSGSYLVKFPGAYSMSDPGVGIDVYSQPGVTNYTIPGPAVWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQQ2</accession>
    <name>A0A2G8SQQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQQ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQQ2"/>
    <dbReference type="OrthoDB" id="2012566at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="487" mass="55468" checksum="B95B7F0E913EBF18" modified="2018-01-31" version="1">MFLKRGYTDFVFDVSDVLITWPSDLTSPIDRKALRSYLVTRSWFQYESGKISKDQCLQDLATKFSHDAGSIDNAWRQVAAALRPNEEMVALIKEIRQMTGGTARILGAFNVSKPDYEFFRSRLDVDWTIFDAVFTSHELDIRLPNPGFFKRVIAKEEWKVNPHDTVFVGHDSDDVVTARSFGMHGVLLADFKEARRELRNIVGDPVKRGWEYLRANAGRLACEADRPGVSIMENFGQLLILEATGDRSLVQLMEPPRYWNYFQGKGILTHENFPDDLDTTSLGLVTLKPPKEHCDSLMDEMLTLLTEDGLPYTYFDRDIPRLDPVVTVNVLHLFYTHGRGHELPGALAFVRSLLENRAYIDGTRYYFRECFLFFVARLLQASDDRHLHDTLEDLLRERVKELIGALGDAIALAFRVVACASVGVPNEIDMRNLLPMQCEDGGWEIGYIYRYGISGMKIGSRGYATAMAIKAIEELDKLRAKQGVEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQX8</accession>
    <name>A0A2G8SQX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01841</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQX8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQX8"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF6">
        <property type="entry name" value="MAP KINASE KINASE MKK1_SSP32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="167"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL36181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="485" mass="53305" checksum="B56AF857B18C2FFF" modified="2018-01-31" version="1">MQSLHPSPARPIGPRSLRSASPHPFQLPDVAPLNVRKPSRDQPNGSSLLSPPASTSPSSRSTTPTPSLPTPPSLMPGPSPRRKPAFPKIELNTLNLGGGSAFSGIGGPQPQDSPQQPLRSNLTNESEPTIRPADHTISPQHPPPHMMSMAVLETQVKEFEQWSDDMLEEVGRLGEGAGGAVYKVRDRRTGVVMARKAITTHEAPMKQLLREIKITSSTEHVNIVHFYGAYISPSSSEVKVLMEYAEGGSLESVGKRMREIGARVGEKVAGRLAEGILQGLAYLHSRKTIHRDIKPPNILLTREGVVKLCDFGVSGELINSVAGTFTGTSLYMAPERLSGNDYTIRSDVWSTGISLLELVTNRFPFPTDLAAIELMMYIVQNEPPELEDEEDIVYSAEMKDFIKKTLTRDPTARPSPKEMLEHPWIVNVMQHKLDMAYWMRKVWKWRKNESTSQASPSRPSSSRSDRPSLDASIASLSINDSGSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR07</accession>
    <name>A0A2G8SR07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR07"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR07"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="108" mass="11086" checksum="269DE33C155CD790" modified="2018-01-31" version="1">MLVVDRRDDVGAYAPGANRAAVQAELERHHYPHAGAYESTAVPAQVEIEGAPAFMGTKQGQHAAASMPLGGGQVHGIAVAGGVPCITKTPGPAALVALLLERVWGVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRD2</accession>
    <name>A0A2G8SRD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation protein SDO1/SBDS central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRD2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRD2"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="2">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="72" mass="7868" checksum="D5DFB9032AE8C737" modified="2018-01-31" version="1">MLQEQVGEKEREHGLSSVRRKIATLVAEKCVDPATQRPYPVGVIDKAMTEAGFSVKQGKGAKVQVSECIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRS3</accession>
    <name>A0A2G8SRS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_00158</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRS3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRS3"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF479">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013430618" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="505" mass="55822" checksum="44CD5F58510E4FFC" modified="2018-01-31" version="1">MFGKALLPLLAGIAAIASVDARMMSKNELHAKQAEAAARIRANMPRATSTGVKNITFSNPRASEFYVDGTTIPDVDWDIGPSWSGLLPISSSPNETRKLFFWFFPPGPQGSLDDLIFWTNGGPGCSSLEGLLQENGPFQWSYGQAQPTQNEFSWTNLSSIIFLEQPVGTGFSQGRPNVTNENDVAAQVVGFFQQFLEVFSELKGKNLYLSGESYAGMYVPYLANFIYEHPTDLNLTLNGFWVSDPVLGWDVVQEQIPAVDFVHKYEGVFSFNQTFLAHLDSVAETCNYAGYVDKHVTFPPKGLLPLPGKSVEADRGCDVWDLIFDAALLVNPAFNIYRIFDTWPILWDVLGFPGSFFQTQSPIYFDRPEVKAAIHAPNVTWAECSDIDVFPRGDNSLPPAFTVLPNAIEKSKRAVVVHGLADFILIAEGTRIVLQNMTWNGLQGFQTPIANDSFVVDGMGAMGNVHTERGLTYYEVSLSGHMVPQFSPKAAFQIMSYLLGFRDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRW3</accession>
    <name>A0A2G8SRW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspergillopepsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRW3"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013903346" description="Aspergillopepsin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="27700" checksum="D36BFAA1C20C5E59" modified="2018-01-31" version="1">MFAATLLCQVLLATAAFAVPTSKERFAQRVARRAGGLSRQTLPKQLIATGATTLATNVSHVEYSSNWAGAVISESSATWKTVTGTFTVPTPKEPSGSSGAHYASAWVGIDGDTCDNAILQTGVDFNVNGNSVSFDAWYEWYPDYAYDFSGISFSAGDSVTVTVTASSKTGGTATITNVSTGKTVSHTFSGQPSLCEYDAEWIVEDFSSGGGLVPFANFGTVTFTGASATTNSGSSVGPSGSTLIDIEQSGKVLTSVSTTSSTVTVSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSJ2</accession>
    <name>A0A2G8SSJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSJ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSJ2"/>
    <dbReference type="OrthoDB" id="3253804at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="139" mass="15849" checksum="DC26CE8B98ECD801" modified="2018-01-31" version="1">MPGLAFSNKLISCNEGLHTDFACLLFHHLQNKPPPSTIVTIIYKAVQLEQEFFHGLNSSVMLQYIEFVADHLLQALDCPQTYQASNPFNFMDLISLQGKMNFFEKCVSEYSTSSYRNSTRGTLYVSPFTVSKLIPYQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STD0</accession>
    <name>A0A2G8STD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_00717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STD0"/>
    <dbReference type="STRING" id="1077348.A0A2G8STD0"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF9">
        <property type="entry name" value="PEROXIDASE STCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="5"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL37025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="242" mass="26233" checksum="8A6AAFE32F5C8421" modified="2018-01-31" version="1">MTNDDRHPYLPATPGDSRSPCPALNTLANHGYLPHDGRSISPSQLVAAIRQVYGLSWAFATLLAYGGAAKCGHADGLSLKLDLHDLAKHNVIEHDGSLVHDDTATGQTFAPTTVDHHLLRQLLDTSDSTHLSLRDLCRAQVRRQAASRPLDSLPSYVSKGELDLIYQVFGVTRGSERGSGSPAEGEELVVPKAFLEEWLGHERLPEGWDGPLREIGLVALVEHVKQISNLETEIKSSGKSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STJ3</accession>
    <name>A0A2G8STJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Golgi-body localization protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00788</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8STJ3"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="3">
        <location>
            <begin position="659"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="2">
        <location>
            <begin position="780"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2180"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1358"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2180"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2209"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2226"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2254"/>
            <end position="2271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2280"/>
            <end position="2295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2295" mass="258597" checksum="5C53779957D97FC3" modified="2018-01-31" version="1">MELTERLDVLEDYKRKESSVEKVVDHQSLLPPMLSPVPRVSFGIHVGALSLRLISPTSQREQEPFVIEARTDDIVASLESNFAARPDHRYGAADRDFAGLDMEFQYGLNMNRPYAKIWFGPDAHMRGVHPEDFRAPSYPSEPLVQIDSIHLGGTGHGLGEFVDEASGIVSVDVSSIYTQCQLATDAISVELWQPEVIGSLAFILSRLASHPKPTSKPSRRILDQLPFGVDASLAIGRFITFLTSPDLAPCDTLNISRGVALRTGVSVTYSALRKHHCSRMSSIILRSHHRTKLMLPKEQVLHVVHEHSKPESHQVTRALIQMSFWDIVVRDAFATPFAADDPYGLDDQSVHHRSLEFLHIDNCDIHVVISGRRPHGAPPPHSMDDCHVEVSIPKVRAKMDLCQIYHALLAVHTVQQLVPSRPGPSSVAPHAPSTIRLHLRFQLQQLQLLWRFPLSSKMFLRLSSLSCRIAPDRKISVAWDNILTGVNVPICRDGREKEEWEELARLPRWRVDLDPNAKPLPIKVKGDSGRLRIPFDFVFADLILDINLTVKSAKHLVRIVHTGKHGDPPSPPAEDAKHVPDIQIELGRLIVEAADDEHEARLGLIWKTGFSAAKLRREREDAFKAKVDTIISPKHSSTSSLRNDSDFQFTSKHTVSITDARSRLDQVHSGAWKTALDQAFSKQTQREESHWQNPIGSLRMSTTVDDDIVRINSVPPVPPLLRFSFNQLSLAITPPSFPYSSIPDYLYEVGHGLPRDTQFSLLVPMRIKFTVSSLRLAFRSYPLPLLHIPPHSSGKIPALVFETDLVIAEEMGTDSSVEWVPCEIVKEHSGLHGAASISVNIPKTIMPVKTYARPTIRVKTDGITDFSWGVSYQPATQDLMRVIDMLSHAPRDSSPAIGFWDKLRLVFHWRLKVEFKGEVHFHLKGSRDPYKLDSHGAGFALCWKGKPKLLIGQPNNASELIQVISDSMLIIIPNIEDTYGDEANKPSAKGGAARRARTVCAKFRSGTCFGVGFTLERTCGPECTECTGRPFDRSCRHFEFKPHYDVRLEWKDQVPTIKSQEDSYNGFRSDFIHMSISLTSGLRKTSHIQASNLHLSPTVFEHFWAWWHLFSGALSLPTRQGDLYPRKRPISPKFGQHLSTLKYLISVPQLYISHVYVDESQDAWADGVTPYVGVKALIGEFRADMHQRDTATTEFTDGGMKTVHNKPFYAIEVVLKSLDLRAMLAVFSDPLKQCTPVEYSPFVSNYRTRNELPSIPLHSKWVDMDDFAFDETESTAVPEVHLLPAVSCPRFTYFKQYDDDMDRKDMPASHSKFGAEDTHVCFIGKEPSVAQVQMDLVSQRIDQLREMVCEEADDVDDNASTHSSNDQSQENDDAKRNRAGHDLSRMITLLESYKLQLRNIDKASQATKARNRNSSYYMPTDLVTPEEWSGFDNVYQVHNPHIVMDNAIRDILMQYYYCSRSRRGFEYHLAQRAVKFIRDQAQAALTEFQRETEKHAGPAASAHAAAARLKTFLTGESNVPAPVEFAPQSVSKLAPTVDPLYGWAEGVSARKGHFCLLLKPQIVLRSNDDQESVCVLAAVQGKLKTFAIMDNANVNDPISGKVMNRNFAWLTGLQTFSPSATNTLGKDYVPLEVLIDLRADNSDFDRLVPQTDATFQYDKFNRLRLRNDTTAVSRSANQKHAHLQNQTDLIRVHVPRFTVSANDRHFQAISNIVTKLVLFTDAAHKTRAEKLESLLFSYDFTNFASAADVVSGMQDRLRQALVTKSVAERKLRGLGNPGRVELLKIDAHILLLVEELNMMFDAIKLAQDKANSESDQKSALLLHTSSEEVSWRMLDQQDQLLAKVAVRVTDFYWLSRHDSSTVNNLAVGDLQAFDGAADAEWTEILSKCDEPATHPLVKRKLFLLAHWTVLPPVGGITIYEAFELSFHPMRLQIDTRVGRKIMCYVWPARRDRTQSPTELESFLIPEPISDDDHDQGLKSSVLPAVTYTDSPRHASFDVSPARRSLDMNRLAPPSPLRRLGTSRSFTDLRKERQDSLKIPMIQRTSSNGNLRDVHGMTKAVSMSSRSTPKDLLRNQQTDDALEMKTRASQKTFVRVKVASLHLLLSISKEDSFLCRDARIRTRDLEYRNQTWSFEELVDQFIPSGRNWRGWVKVAFQQPLVPVFPVARELITKTKWIAANKKDAHHNDRPSRPSTPKLLKTPRLPPSGDPPRRSTEMPRKSKDKDTTATILTDATFITSGPQLMREGTTQPKREGVRKRAMSLFRRKHRHGHHDSSDTLEGSDSVSSVGSPRSGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU29</accession>
    <name>A0A2G8SU29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU29"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU29"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="4">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="426" mass="47146" checksum="C356C2A23533AA41" modified="2018-01-31" version="1">MAVTTKQLWENAIAHLHDLSDATLYQKTELEARVAELEAELSAVKSAYSNATDMAALDKKAHNAQLSSLNKQMALTFPKAQDPLVLCVIDGDKLLFCRYLIEQGVQGGRHAAEDFTKAVAQELVQQSLIGFERLSFWVTIYLNKRAVMARLAGEGIASPQQFEDFLIGFGQASPRFLIMDAGPGKEQTEVKVKEYVKTFVRVPQTLRVFFGGVDDAYFGMYDSLMQEDLAGKLVLLQPPVDQSPLVRQMAVRRARFDGLFLEERLSPIPIRRPGPLGISQSNLHPHVITNGGLISPQSETQTSISPPPADRSPDGLRQIDPSKPLHKQNPPPCNEHYLMTCSKGPNCKYSHEWRLSPDQLDVLARNAKKAPCNYLKNGLTCPYGDKCCWGHVCPSGARCFHLSKGKCWFKGDGMHPSSAPSPVESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUU5</accession>
    <name>A0A2G8SUU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUU5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUU5"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="14"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="295" mass="33015" checksum="D2CE86B9FA18FF3D" modified="2018-01-31" version="1">MGDMLDASVDGYEISVGDLTFTHKEGDSPSLSGVNIRLPKGSRTILVGANGAGKSTLLQILAGKRLISSPGTEVRIKGRDVFRQTPDGITFLGTEWAMNPVVRGDIVVSDFLNSVGGYRHKERRDRLLDILDVDLDWHMHQISDGERRRVQLVMGLMGDWDVLLLDEVTVDLDVLVRDDLLTFLKEDSENRGATILYATHIFDGLNNFPTHVAHMHLGTFLMEPTAWPFTSETMGGTSVDLGPKPTLYAVALQWLREDRDRRRALEAQGRKSRGARIETVPSDSETFYKKYDYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLJ5</accession>
    <name>A0A2G8RLJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLJ5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="92" mass="10287" checksum="2B28009950078B99" modified="2018-01-31" version="1">MILIVAQNNRRVLSLYIYNSRRPPELPISHAIHCPTPQPWPPIPGPGRANVLYTRYNPAESPLTIDASLMYVRKRADAINARSAPPGIAEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM99</accession>
    <name>A0A2G8RM99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM99"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM99"/>
    <dbReference type="OrthoDB" id="2720823at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32353" checksum="9C7ACE01E3507DCE" modified="2018-01-31" version="1">MSETHRPGWDKPLDPALYTLDEEEKAFMKAATGIQDDEELKTHVLAVQTKAFASWFSNRLRMARLPAYNAFIALGKQREGAILLDMGCCFGTEIRKAALDGWPVTGIVAVDLSKDLWDLGHELYRTSPETFPVPFLQGDILDPANLTVAPFPTSPTPLPPDGFSLGEVTSLNQLHGRVSAIFVGAFFHLFTFDGQERVARLLAGLLSPLPGSMIFGSHGGLEAKDIWSPAEGTRMHCHSPESWRELWEGIFAEAGAQVKVDAILRPRSGGITIHGTYPENAVIRPYLVWSVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN40</accession>
    <name>A0A2G8RN40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_15421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN40"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN40"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL22728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="543" mass="58687" checksum="6F235C2A31F44651" modified="2018-01-31" version="1">MSNHSSVSREPEKAAPSVSVQDAKNVLEPKFKDPAGDVEGATMVYIEDHDIFDGEDAAIDPVYQAKARVLNAAFQEIGMGKYQQVTGLIINPVVNEFVGTKGPFLILPQTIGLLVGAVFWGVGCDLWGRRWSFNLTLLITGIFALAAGGASNEVALCSLIGVYAVGSGGNLPVDSAVFLEFVPATHQWLLTVLSIWWAIGQLVGALVAWPLIANFSCASAVGCTKEKNMGWRYLLWTLGGLMIVLFILRFFVFHLYESPKYLMGRGRDEEAVEVIHAIARYNGKTSSLRVEMLKQCEKYAIGGPVSDGEKEKDGQEDVKVVPMDTSLRAALVRKLRMMNSDHVKALFATKKLAYSTSLLIVLWAFIGLAFPLYNGFVTVFLQQKGAETGDGSLNVTYRNQVILSTMGIPGSLLAGWMVEQPIFGRKGTLAISTVLTGVFLFASTTSHTSNTLLGWDCGYTFANNVMYGVLYAISPELFPAKDRGTGNALVASANRIFGVMAPIIALYADLTTPVPIYVSGALFVVAGLIAVLLPFEPRGKAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN88</accession>
    <name>A0A2G8RN88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="8" type="ORF">GSI_15679</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN88"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN88"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="231"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="460" mass="52562" checksum="949EEF16BC4BAD08" modified="2018-01-31" version="1">MAEYDLTKTIIPHCDRHLVFPLLAHLAESDLFPVEQVQTAQYELAKETNMVDYAVSLFEQTHPDEHVPPEFADKREKAVSTNEQLQQEAQAVLDVIENPEVAQSLRQDKNQNLQFLRDHYNVTLEHITALYNFGKFQYSYGNYSGAADYLYHFRVLSTDPDLTISSHWGKLACDILTGKWDVALEELNSLREAIDSRAPSHPQFAAPSSTADPALAQLHSRTWLLHWSLFVYFNHPQGRTLLLETFLSPTYLNTIQTSSPWILRYLATAAVLSRKSASGALSSRVRHSIREIVKVIQMEEYQYQDPVTQFLKELYVDFDFEAAQKELSKAEVVVSNDFFLGDFRDDFMDNARYLISEAYCRIHQRIDIGDLSERLNLSRDEGEKWIVNLIRETRMGADAKIDLEKNVIEIHRPPLPIYQSVIEKTRGLAFRTQALGAAMSRTQQPPGVQDAAQPAVVEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNL3</accession>
    <name>A0A2G8RNL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-8 sterol isomerase</fullName>
            <ecNumber evidence="8">5.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Delta-8--delta-7 sterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_14401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ERG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNL3"/>
    <dbReference type="SMR" id="A0A2G8RNL3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNL3"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="UniPathway" id="UPA00768"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL23093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="238" mass="26494" checksum="BD3476C60A9FBAF6" modified="2018-01-31" version="1">MPSTKSGTKAAPKSDASASCLRKWVTRAVIAFVVYVTCSFLDRIKDRWYVFTPEALHALAQDAVKAHPNDINAIIPHIVSNLSAEHPSSVIALNTNSSEWVLSNAGGAMGAMYIIHASITEYLIIFGTPLGTEGHTGMHTADDYFNILVGEQWAFSPPNLAMEVYRPGDVHHLPRGHVKQYKMHEGCFALEYARGWIPLMLPFGLADVFTSTLDYWSFYHTVRITARENIRNFLIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNP0</accession>
    <name>A0A2G8RNP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14443</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNP0"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="323" mass="34709" checksum="B73A8EB8D54B00E5" modified="2018-01-31" version="1">MRYTVGLLTGRLFDKGHLRLPVFIASALFVAWFGIGLTSGVFFTMINMTMAHWFKKRLGLAYAFMYAGAGIGGCVFPVAFKTLVQRMSFPWAMRILAFITLVLLAVTNLTIARRLPPKPDRVPVINISEFKNRTYSLYVVSLFMNALALFTVLTYIITSAVKAGIGSNMSFDLLSIMNATSTLGRWTGGYLADRPLTVLTSAALMSAILTFGWPFATNVPGFAVVAALAGLSTGAIIATLVHPFTRMGPVSDVGVRIGMGLTIMSVGILAGPPIAGAIVDATGSFRNVGLYAGPVGDYYVRCEAVNCRDRSGRLDVDYTAAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP52</accession>
    <name>A0A2G8RP52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP52"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP52"/>
    <dbReference type="OrthoDB" id="2660687at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="234" mass="25393" checksum="738DA8F1F11B075D" modified="2018-01-31" version="1">MVSREWFAHRGGVRHLVVSPDGQRLVSLGRSLGIPTIWDISNDVHKAAQLEGHTQPVSACAWSPDGTLIASTSVDGTVRVWDAQTFKQCDLLQDPVHASGYLRVLFSPNSRYLVAWTPQLPKQWIGLVIWHPLTGDPPTRLPPMSSAIGPNDHIKALSFDTESRRIVTSHGREVGESVIRVWDVATGAALTELVGHRGLPTDVSFSPDGRSILSVSCYGFAKISDGGTGEKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPP9</accession>
    <name>A0A2G8RPP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPP9"/>
    <dbReference type="OrthoDB" id="2764441at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="13474" checksum="E8463FCC58652713" modified="2018-01-31" version="1">MPASITYIAVDDVGDDRHRICVELSPLALQDVIGLDYLASFARPVDDEYPRGVVISGYLTGDEARGMHYAFGTGILDALWTEVFLDDYILIELSVSRAYDTTRSWRLQFNLLAATRIATSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPZ6</accession>
    <name>A0A2G8RPZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPZ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPZ6"/>
    <dbReference type="OrthoDB" id="2737640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="3"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="382" mass="43462" checksum="BEADCF100574D2F7" modified="2018-01-31" version="1">MRVPATAFTFSLLKFFQELNFQGKTNLYDFWKTIERITDNSGGIDVPNRYKQLSHVVRLWRHLTMLKRFRRTHDPTGAGGTKLGELVVECAACPHPDKNLPDNWESSPPHLKWLYTLFLMMDANFHARCKDRGFDDVELAPGWAYYVEETAYLTHIMMRTDEKDLENTCSAEHNAIRQASFHREGYIASGVGAILCARHALVRKNGAGDLQQGERQANMDYLFFVTLLGLILTILISYDIEAIVSAWNWDHTKPDPYEEPSTTISMSTVKLELAQQEAIEGAQGLLLTHEVTPAVFIQVGLELEEQQCALRQRTSTSRSVSDLADLQSKRNVLGWRIDSWRGIQDIHMPLAVQLRATEPERPTTSPPIKPEDIKLWLPSSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ78</accession>
    <name>A0A2G8RQ78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13419</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ78"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="92" mass="9805" checksum="C182BDFD77AB0B4D" modified="2018-01-31" version="1">MARLTTTPSSAQSIVMDNQVAAHVHDTPNDGRSQNSAIPDTLPDFAVLSLTDSDVSDRGTLTLLMSPRGGAYCTGRIVTILQTIVHVTQQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQA9</accession>
    <name>A0A2G8RQA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQA9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQA9"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037626">
        <property type="entry name" value="NUP37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806:SF0">
        <property type="entry name" value="NUCLEOPORIN NUP37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22806">
        <property type="entry name" value="NUCLEOPORIN NUP37 P37 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="370" mass="39929" checksum="A9524F78DA7825A2" modified="2018-01-31" version="1">MDVRHSHGTEVHVVRACYEDDAADLIAVGGAHSVEVLLLSESSCKTIANFHIGSRVTAIAWSSHVSSPSSADDWSIELAVAGADFSLYLLSKSASSQEDIFPFGGGLSGHHGKVNDMTFCGGRSEDSMRYVATVSDDKVLIVWDLSPNLNIASPPSPTAVLPERPQPTAYVINFPHPLTGVDSHPSTSKELLVADCRGSIFLTDWRSDPDENEQNSWRKHSVVEVVEPRALADAASGLSTTWSGSVAWRRDPSAEFVGAAYGSKFALWDLGNLYGGKPYVAGTSFAEGGHQFRWCPTYPDYFAVSTSSPAKGAIIHVHNVNYTHAQPTAFQIAPRPLYVRSFDFVACRGIPRIVAAVGRDVVVFYIGVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRD0</accession>
    <name>A0A2G8RRD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRD0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRD0"/>
    <dbReference type="OrthoDB" id="3173976at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362:SF309">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24362">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="289" mass="32813" checksum="2AA64FB375B76C9D" modified="2018-01-31" version="1">MSAASSSSHTPRPSPPRRTEASDSDADSDDDSLSCRSSIDEEAVNTRVSPNWCSYRCIIASRGFRLDTCKDVKEWYHQYWETQASEGRTVTKDLPGYLRACRGQDEDELCRDAGLPRVRRHPATFMPDPAEPSHESLHTESSIPMDMLAVLDLVEVPKDELAFIVMEEWPAPLTTAVPTNLGEYLNFLRHCIEHTAFMHMHHIAHLDISPRNIVTDICGRYACIDYECSMRFDSTPEPRICHARIAELPPEMERGEPSDPYKVDVFGLGVMMLRTMKVRVDHGVIHLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRZ4</accession>
    <name>A0A2G8RRZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_14040</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRZ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRZ4"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF18">
        <property type="entry name" value="PROTEIN GAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="65"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL24287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="322" mass="35270" checksum="9B42E90944BC8C69" modified="2018-01-31" version="1">MASTVPVSSPTSASTSAAATMPEASGSSSSNSAPLTPTKEIPVFEFTKRKRWADLLVTELNDTIIFVLSEACTVWYCGNAVTELLGWRDEELVDSDLIDLMNAGDRVNFRTAFAESVRARTEMLAYARLQCKNEFFVSANLTPEPREVLFEIRGRPHYLPDSGDFKCYFAMAQPYPSRNTAMLNTFLELKMENERLQQRVAQLRLQSQALDGAADSFFSTSENFGVPAVDGGRTNFEPGVGPSLVTDADEDGPRKKLKRAAAEQHVCVTCGRTDSPEWRKGPNGPKTLCNACGLRWAKKARKNVEGEGEGDGAQNSGSTLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSG8</accession>
    <name>A0A2G8RSG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="2 8">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_14041</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="8">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="2 8"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSG8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSG8"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL24288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="435" mass="48881" checksum="9BD27D729D75450D" modified="2018-01-31" version="1">MTDTPHLADTSPQHWKYISEGGSSIVFSYSGPPHPAFNGIALRLRKAPVPELRRHEDTEQHQQPQFGEGEEHEPDDPTIVFQHAVIERLVPRQFLPRLDAVRVDRVWLQELSDQIEAQRPAQRRMKDRIDRGRRKAVLATDLVGGSGWAVEIKPKWGFLPAPAHLSEETREIKTRTCRFCMHAHLKSAQGESVALGYCPLDLFSRDRQRVTRALCTLWDVWIASGATVNNLRVFVEGQKLTPTADPISLAPLAAHLFPPEDPPVRTQTLDAIRDAFTSALLPLLLDTPVLQTLSTLQRTLDSLDVDGLSALWARLRPEHATKLGKGEPEPTIGDWTRFVDTYLAPHARDGDTASPEETEDELRYRLLAYLLSASFKDCSLILRMRPGQAGTITMIDLDVKGIDRLVKWAKLDREIIDAYRGVAPRNCVDSWASSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT99</accession>
    <name>A0A2G8RT99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT99"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT99"/>
    <dbReference type="OrthoDB" id="2745559at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23456" checksum="3A0AF07D97BCDA0B" modified="2018-01-31" version="1">MTAHADVLPFPLIVDKLCHRATVRLCTLAPPHPLVPHIRRAAARYVKRHRSQLHELLNAYVAPDTPVRIEKLRPARYHPNSTPAASALTFDNKDRALDEDEKWMREHKVSVYSDGSEKDNKVGAAAVLVRRDKPYRRTLRYHLGPSSEYGIYEAEIAGAIMGTELLRTEREVVDGPSVALDNKSSIDASQQISTRPHQEKPPIIFDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTC1</accession>
    <name>A0A2G8RTC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTC1"/>
    <dbReference type="OrthoDB" id="2752332at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013863145" description="BTB domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="27706" checksum="ACF1A05331BC0436" modified="2018-01-31" version="1">MWQLLQIFLIVLSFLQSFSPLIGKAGGLFQILELPLAHSDDVSQQSDISAASSRDGTDTSASSERGDEPEDAPLDSNLQETKSNTATGDSNSPLEAVTAAPRSELEALPAEQDHPIGSERVAASVGSDDDTAPDTSATAELKRDEELWFEDGNLILIASEVEFRVYKGPLIAQSLVFKDMLSLPQPSSSDTRSNQDTDTARPSTSCATVHLQDDSLSDLRHFLRMFTGHTVSYVTSAVVSKCLHVMRCPAADHILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTG6</accession>
    <name>A0A2G8RTG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTG6"/>
    <dbReference type="OrthoDB" id="2735257at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="173" mass="18204" checksum="5C184C4C78CE1E73" modified="2018-01-31" version="1">MSSTTTQSSSHSHALHVIIPTSSAPRAPSESTPKTSTSERVPGPNPLDTPSHSHALALDTPSHSHALFALPLPADTPTHSHNFFRRLSAATPTTPKMSVRAARRSSLFSMHDADEPEQDVGAAHGPEHVQQGFALLPPTSETEEGESGADLGDLKVVGDREFHVEGDGIGGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTV8</accession>
    <name>A0A2G8RTV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTV8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTV8"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="86"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="525" mass="57864" checksum="53815DC5CD47B142" modified="2018-01-31" version="1">MAVHQVTEEEPMPIDSLATKSCASASVQEAVAHARISQAAEDVEKQDGEKTHKKSLDTLNEITYVDFDEGDPRDPANFSYRRKWAITVTASFFSLITASSSGAYALGFPSMTRDLHATRFQGTVGISTYTLGFALVPLVTTSFSEEFGRQPLYIVSAIGCLLMHVMTALAQNIQTVIVARFLAGAFGSTSSAMVGGSIADIWAPYQRGLPMSVFAVMVLAGPGIGCLAAGWIEQNPHLEWRWIQWIHVILLGVLLVAMPVCMRETRAAVLLTRLARKMRRETGNALYRARVEDERASMRTLIYISCTRPIYLLFTEPVVASFSLWVGFAWGILYVLIESVGPAFSDIHHFNTGQTGTVFVAMIVGCFAGESIQLYQERLKYHPTKGPEARLFSACLAALLFPAGMFIYAWTASPSVPWIGMVIGIFVIMTALFILYVAVFTYLADCYGIFASSALAGQSLSRNIMGTAFPLFTQQMYDRLTYHWGTSLFGFVAVVMIPIPFVLFWKGPAIRAHSKFASQVVHHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTZ9</accession>
    <name>A0A2G8RTZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_12866</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTZ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTZ9"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="299"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL24979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="595" mass="64611" checksum="ED118A0F366DCF00" modified="2018-01-31" version="1">MSKEEYAAVPLLPSTASHAAPRKKGSCRAGLAVVKALLFGVGLFVCLNAVGLSPIPRCVTDRLAPDHHWKAEEQCPQATAVVPTKNAELWNSLGDTYGTDAFRSRAVEWLGGAVRVPTESYDKMGPVGEDKRWEAFGPFHDYLSGAFPLTHSSLELTKVNTYGLVYVWKGSDASLKPLLLLAHQDVVPVNPDTVDEWNHPPYSGYFDGERIWGRGSSDDKSGLIGILSAIESLLESGFQPTRGVVLGFGFDEETSGFHGAASISKHLEKTFGENSFLLLVDEGGGFAIEYGGVVATPGIAEKGYLDVRVEVTSPGGHSSIPPEHTTIGILSQLLVHYEENPYEAQLSRGTPVYWKAQCLAAYATDLPHKLRKDLKKSVKSDKALKAAQKELFKSKAFHALVGTTQAIDLVNGGVKTNALPERAWAVVNHRIATDSSVTSIQAHDTKLLKKLAEHFNLSYTAFGAQVSEQDVPAYGTLTISDAWGGGLEPAPISPIDAREYALLSGTIKATYNAHRSLTGDDNIFVAPGIMSGNTDTRWYWALTEHIYRYNHHNAGNGTSLANGVHTVNEFLVVDSFLEVIRFFTTLILNVDEFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU47</accession>
    <name>A0A2G8RU47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">L-serine ammonia-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_12930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU47"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU47"/>
    <dbReference type="OrthoDB" id="192663at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000001">
        <property type="entry name" value="L-serine ammonia-lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051318">
        <property type="entry name" value="Fe-S_L-Ser"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005130">
        <property type="entry name" value="Ser_deHydtase-like_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005131">
        <property type="entry name" value="Ser_deHydtase_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182">
        <property type="entry name" value="L-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30182:SF1">
        <property type="entry name" value="L-SERINE DEHYDRATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03313">
        <property type="entry name" value="SDH_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03315">
        <property type="entry name" value="SDH_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine dehydratase beta chain" evidence="11">
        <location>
            <begin position="54"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Serine dehydratase-like alpha subunit" evidence="10">
        <location>
            <begin position="267"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="67022" checksum="6FBF67A6BB0C4760" modified="2018-01-31" version="1">MATSERRNDDTGIAVNRSHLKQDKGEEANDGVIPASESSPIGSHEHKHEHAVISAFDLFSIGVGPSSSHTVGPMRAGKIFIGDLEVLGLLDKVKTVKISLYGSLAATGKGHHTPQAILLGLEGSDPETIDTGTIPSRYTAILENKTLILGGRHRIEYDMDKDMVWRWDQVLKIHPNGMRFSVFGEDGDLLATNEYFSVGGGFVVNEKTKVDENLFYKGVDKSVVHGARLHQPSHTGSDSMEATEMADLNQPPYPFVSGDSLLTLTKKHNMTIAQIVYDNELHFGYSHEEIHEKLLRIWSVMDDCIRTGVSSAEEKLPGRLGLRRRAPLLYRRLMRGFYPGLATPTLPTIDGRPFSAGNGNITAPEEYRILLSARSESEGEQESSGRSASGQGAGRKIAVSRPTRVVGVLDHPVTPVPPRKTMIPAMDFLSCYAIAVNEVNASGGRIVTSPTNGAAGVIPAVLKYIVEFVSDDPEKSVVTFLLTAAAVGMLFKRGSTISAAEGGCQAEVGVACSMASAGFAACMGASPETILQAAEIGIEHNLGLTCDPIDGLVQVPCIERNSLGAVKAITAAQLAMASQNVYSVTLDEAIEAMRLTAADMSVKYKETSLSGLARTVRIPLTVPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU77</accession>
    <name>A0A2G8RU77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU77"/>
    <dbReference type="OrthoDB" id="2728951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="151" mass="16604" checksum="C1464A8F67796912" modified="2018-01-31" version="1">MSYEQTQKLSGPCVGTKFQEKIQEHNKLRSETVAAAAEVTMCSLDATPPQMREHLDDQANLLNIPAVGSEHNTTFPFMQMNVVSTQPCGQGSKNIKAQLGRVGGKHFDLHDAGGGITSMITDPETEDWGWFIVCDLEIAIELGWKWAISGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUI2</accession>
    <name>A0A2G8RUI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUI2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUI2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="154" mass="16771" checksum="59CE80BABB3D156D" modified="2018-01-31" version="1">MSLPFAPLFIDGEWRPASNGATFDISNPATGKVVGTSASASEEDCVAAIETASRAFKTWEHSPLAVRRDVFLRAADLFETEKYREKVAAVTKEELAVAADMTLFNYTMQPNHLRNYAGAIQLLKGETFPSVIHGGQVFAQRRALGVMRVKPAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUJ7</accession>
    <name>A0A2G8RUJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUJ7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="131" mass="13693" checksum="6808AF37571668FD" modified="2018-01-31" version="1">MKDGSIGVVGDEARGARGSVWISRTISEEDERCRIGVGVRNAGSEGRADPKFDGVGVLLLGVVEEEGETVPEAVDDTVTRLTKRVQGVVRCVDPGPEIAGGGHVGAKAPVIFGDVGQVVERVERRDSGVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVB6</accession>
    <name>A0A2G8RVB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVB6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="77" mass="8684" checksum="72EAD1388D86BCAD" modified="2018-01-31" version="1">MKERVPATVKECRRSLSILHRRGLLRVAVAALGEKKDEAWVCVWPEEGAPAASSYTRQYDVRELLYAVVNVLDKTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVK2</accession>
    <name>A0A2G8RVK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000047">
        <property type="protein sequence ID" value="PIL25540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVK2"/>
    <dbReference type="OrthoDB" id="79252at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="648"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="865"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="899"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="960"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1021" mass="110053" checksum="8B46FDCF17FDD318" modified="2018-01-31" version="1">MPSDATEAALGLLGLTGAFPSSSTTPSIPAKRKQPPARPRSPPSHDGPESQSSDSISCICGFSFDDGFSIGCDSCSRWSHAACFNIVENQVPDEWQCWICAPRPVDKDRAVKLQKARLRQAASNAQSTTNPTSNGRRRSSPGVERKTRRPSTITSAQDPSCHPNDKPTHTNKRKRRASTSIHIANSNTAHPQEDEHVDIDEPWTHSYVPTSKDIVPADETRDRLRRVACDWRGVSAINGNGSPNSRLHTPPLSRRTTFPTHRPRSVWPGLYANGSGSHSVRPPSYAVHANKPIQSSKLIAPYPSTIIPTSMYLRDPLNAYAHLGMPKPYVHLFGPPLDVALDSRITGDQSRFVRSGCKPNAILRPMLCGAHGKKTGKEGREDEAITFGIFALRDLKPNEEVVLGWEWDVDNVVHHLPALIQSPFTFPPHQLQHFRNQMTSMLHSLASTFTTCACGAKTRDCVLNRIAEFVENQTPLTPSPSPPSQFTKEKEKNSGKSRKCDPAESSPAPVDLGPLVGIERGFRTRERIPSSGGMGGVEMVPPSPSAEAGPSRLTADTPRRVSFPDDLIHSSKAKKKGQKGKGRAVDEEESEGEDIQGRSRARRPSGVLSDTEAMDVDAPSPQEECLPPQEECLPPRLRKAWIAKSLERLRGQRDGGAISPALSNGEGESRMDESYFDSRDMPPPPVPPSRTPPILSTSLCPPPISATSSTSSTSSTSSKQRVATDGTASPSVPFSKLSLLSPVVPLSLNTPTSTRPKSPSVPPTPSASKPESKKRRRPTDSPQPPLSDLIPAKSAKAKPVKGKEKAKDKERDDESDEEREEAKPKPKPKSKPKSKTAKEAKEKLVRPSTPATESDEPVLKSSIVRRGDKKTVARGKEKEKAKARERDKEKARSASAELSGARSTASASATASPCVPPTALAPLSSPGPPPTTPIIVLPELPPEPPDQKRWSVAVKAPDAVVDKEGQALDARARGRGSRGGRCRGGLPEQDSPASGTKPTKTALAGETSAPRCARAPRNGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWF3</accession>
    <name>A0A2G8RWF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWF3"/>
    <dbReference type="OrthoDB" id="2590746at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="81" mass="8893" checksum="8CF4AA8C32E91AE5" modified="2018-01-31" version="1">MLSSISSFLPSALQIGGDKPHQPLQESPTQITQSPTKDTEDMAVDEHGVKKKKERTNEAWPHAYLLASGTSRSADQQWLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX96</accession>
    <name>A0A2G8RX96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX96"/>
    <dbReference type="OrthoDB" id="2756463at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38640" checksum="896AEAE069277F60" modified="2018-01-31" version="1">MTEDCILLGDHDTASVSSGCSSYPEETPVFSEEGKLLVQIGRDVFLSIQEEGDIRCLGRTLSSLPSFSRIHLEVRHPVGLRALSNAVGFGALAHEDFAKVRVFKVDLTATLSSTLDDLATVFCALTHIRDVQLFMPKCSLGSIYLPHKRIVHSFIAESSTIRSLRCPAPPLLCLSITVRLEEQGDIYSVVSRLFRNSLTKLRVLRRQELGATFAMSSPARVCPFLDLPRLHYLEVRDLATLSDSGLLDVPDTVSASSWMTTAVRRRLPKLATLVWAPPWYNFRDYAPAKYHDAVAAYQWDLVRVLGSTTLVMCVSRAEGIVSHPSVDGAGSYKHMERVFLDEDEWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXG2</accession>
    <name>A0A2G8RXG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="13" type="ORF">GSI_11961</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXG2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXG2"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000032">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="11">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="220"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="35"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="429"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="530"/>
            <end position="531"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="539"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL26206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="615" mass="68797" checksum="C14411A33D6397A2" modified="2018-01-31" version="1">MSSPPPSPPSSSRCPTPTDDADTHDDRALAILYATETGTAQDVADRLARVCRCLHIRAQVHSMEAYSPAELINEHLVVFVVSTTGSGREPRAMTPLWQMLLRADLPEDLFEDLHFAVFGLGDTAYEKFCWPAKLLSRRLEALGALELCARGEGDEQHHLGIEGALSPWIDNLSGVLLQVYPLPDGLQRESLDGLPPPRVAITDADKDAQITRKDPLVADREYHAATVAVNRRLTAEDWYQDVRHFEFELAEGVEYDPGDVAVIHPEAMPQDVEAFLSCIGYANTADDPIEIRHTLLDQHLPDHIPTITTMREIFTRYVDINAVPRRSFFALLKHFAQDDMEREKLEEFLTVEGADDLYEYCQKPHRRIHEVLSEFRSVHIPRAYVFDLFPPLRPRQFSIASSARAHPRRIHLCVAIVAYRTMLKLPRRGVCTTWLLARQPGDRLQIGVQKGFIALPPDPATPLICIGPGTGVAPMRAVIQERLHADPGVAGKDTLALYFGCRSEAKDHHYGAEWRALAVEGKLMYRVAFSRDGPEGKARTYVQDLIRADAPRIWELVGTRGACVYISGSSNKMPAAVRAAIAHAVKTEGGRTEEEAKEYVAQMEKEGRLIEECWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY93</accession>
    <name>A0A2G8RY93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY93"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY93"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="208" mass="23892" checksum="EB2419FE2080D3BF" modified="2018-01-31" version="1">MPMLIAELMISRENIHSETYAYFVKTFVMDAEERDRLFGAIETVPSVKAKAEWCFKWFDREAHSFATRLLAFAIVEGRGVLPGLCFSNELIARDEEMHMRFACLLYAELTEKVPADTVYGMMMEAVELEKRFFSDALVALFDGLNAAMMADYVEFTADYVLLCMKYEPLYNTSNPFMFMTMLRLPGRSNFFERPVSEYSGAVVGWGPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZQ0</accession>
    <name>A0A2G8RZQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZQ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZQ0"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013661392" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="123"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="413" mass="43650" checksum="7ACD5E1770993D53" modified="2018-01-31" version="1">MVAITSITSVVVALAAWAYATTPATTTPPTNNAVPPQAVLVDPLTFNVLGINGSFREDAVAQFFNPTNTTPPFFQVFDPTFLSILGPNATIRSIAANPGFAFAHEAPVWVPQTDEVFFASQDGGALGFSDINHNNRVSKISLGDIERAIKAAGPGVSPVNVSVTKIDLPEAVQMTNGGTGPFFGQIVLVNSGRGPIPPSLVLVDPADTSNTTVLLDNFFGRQFNSLNDIKIHPKTGKLFFTDVTYGFLNHFRPTPLLPNQVYRFDPVTGSVRVVADGFDRCNGIAFSPDGSTAFVTDTGLNGGFLGNNQTAPATIYAFDVDPKTSAFTNRRVFAFVDTGIADGIQLDAAGNVYAGCGDGAQVWNSEGTLLGKFFLGTVSANLIFAGDGRLVILAETAIFLANIAAKFNRVSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZU7</accession>
    <name>A0A2G8RZU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_10153</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZU7"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="338"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="566"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL27014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="684" mass="73813" checksum="DE62E19D92514B96" modified="2018-01-31" version="1">MSSSAHAPSPSAAPASASPSGPPAQNATAGGPPPSPGGAGMSMSPDRAIYFARDEAYPEQLWWLVAAFIGLVAVCQLASWALAKWSLARRLSRKKTTTGDAVENGGSPGAAGRGFALRNVPTALVNAYRVVAFRWTLEIGQSYTLNVAEVFVTVAYIVALFCWEFLGTTNLEGQKLDIKYWGTRAGILAVSQTPIVTALGTKNNVVAYITGISYDKLNYIHRMTARVIFVLLWVHGASKLKFADEGTWEEWSARVALTALIAFSALILVSIRPVRSQAYEIFYFVHFFMVLIFLLGGYYHANNYRYGTYVWPSLLIWALDRAIRLARVVYYNHLYFGFSKKAGRLDASVELLSPHFVRLHIQRPPHFSWTPGQTAFLTVPGVSGNPLECHPFTIASVDSHYQLAASASSTSKNEKKAATSVAVSPARPGDDDASPYWKELTFLINVRSGFTRRLAARASAQAPAPVGAKVAVLVDGPYGFSPNLDNDDTVVLVAGGSGVTFTLATFLGVLSCVQSGRSACRRLVWIWSIREPGHIEWVSKALTRALSRAPPELEISIRIYVTGKGAGASGKEGAREGGAGERGELGPEWKDDDSVHSSSEGTAVGRSRPPSLLSFDAVQVCEGRPELHELLREEVEATSGRISVTVCGSQGIARACRKALRVPLSMSLRGGPSVVLHVESFGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0R7</accession>
    <name>A0A2G8S0R7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10492</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0R7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0R7"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013943385" description="Glycosyltransferase 61 catalytic domain-containing protein" evidence="8">
        <location>
            <begin position="29"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="9">
        <location>
            <begin position="177"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL27345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="485" mass="55250" checksum="08126D218696E586" modified="2018-01-31" version="1">MPPFHPTPREIFLLILLLGCLLFFTANLQRHPTHVSDLISSPYAVQDEVPAKPLTLETQYTLQTLNVPLSWGAGSVPETKIIAHVPGWTIFDRLYLRNGTLYVVTDEPESIPDRLYIVSSGAFITSDPQDIPARAPTDQSMRVISTAEARQLFGTEADRLDGVSWLAYDPKQFITHYYHWSAELFFGFWRTYSSLDPSIPPSGETSLPAPRRMIFPHLDSNNWRDYAQMNQWVVRAAFPSLSMEFMNDWKERAALNRTLVLDRVVLADRAAAMHGEMYLRTQRTAANAFTLPGSVNWWTTIRNNVVGFSLQGDASDAATVQGIETKPVITYISRQGWNRRMLIQADHERLVAELYKLRDEYGYEVNVVEMDKLTRTEQFQLAGRTTIMMGVHGNGLTALLWMRPTPRSTVMEFFFPGGFAHDYEYTTRALGMVHYGFWNDKHFTRPDVPQVAYPEGFQGNEIPIDGAAVARLVRERLTLAEEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S130</accession>
    <name>A0A2G8S130_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S130"/>
    <dbReference type="STRING" id="1077348.A0A2G8S130"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15937" checksum="7AF39B0A46C5BAC8" modified="2018-01-31" version="1">MGGECVSNGGRWEVGTTPMQLTETGKRLFGVPELNIQQMHRDHVPAVPPSFHLLGASSITPNQGMVKLYPGAAPESVSPSNVQVFCVQGHPEFDQFIVDEIVKARSASGVMSQEVVQDVAQRREWRNDGIGVIGKTLWEILRASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1A5</accession>
    <name>A0A2G8S1A5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1A5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1A5"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF3">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="748"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="31"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="627"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="769"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL27552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112881" checksum="D530C50D6EE7862F" modified="2018-01-31" version="1">MSSDSPAEDDILNPKTKGPPAPKKSSVWDKLPPWVANNLRSKKSWKVLLRCWLAAWASFVIMLPMKSLEQLGNTAFFALLLSFMMPPNMPVQIFLMVMLTLVLGIALGWALSCAAMAAALAARNQTLLKATLEKEVQSAAGLANPDALFRNAIFDGAFLDTRSTVVFGVFLAFGNFLFALIRAYAPKLTLMSVFGTIAIDIFCSYGPLFPFAQYTLLNSMLTSVGCYVAIALILVIIVFPESLNHSYLDSTSALLQTLKGLLASQEEILSADPHVLPGTPLVGNVFGMRTGAIQQLQQLMGQKQMLDFEVSWGRWCAEDVEGMLEPMQIVVTRLGALVNFIKLMALPMSLPDSASGDTQSVGDESTASSTAIGDTYLLRQFRERNTAAETQYHVRLVDVLPNIREATAGVRTSGVDVLNALQKLVVSINSKRYKRSHAEQDALLLQLEKSLNGLRDALEDFENDRRFILLQPFRDLLDRADAGEMKSIPLRSLHISFVFMSNLVSTSNAIVVLAEYVSKTAAKRPKTRLWLPTGMRAIGKALMTRGSAGEAVGEDTTPEEEIEMHNTQKYKRDPDSKVPENGMQKLADIIHRLYLWTKTPEALFTSRYVLVTIALWIPQVVKGTAGFVYQERGIWALIMAQTTLNIYASDQIFNYIMRLGGTFLGALVGMVCWYIGAGNGNGNPYGLAAITGVILVPFIFLRIFAPPQYLSAVIMGGATFVLVVGYSWIDGNLPGIFKSVGLGWNVAWKRWVLVMIGSAASFILMMIPPKSGRKAVRLRNASIISGLSYLYSHLTSLWLAAGEPLDSLHKLEETQRRWPSELREMVITLSQQLQDLRVRTVMSKWEGNIRGHWPFEEYNQLLDLQVDIMSSLVLMASGLTNLEPTLRKASLPHTFVLNPHFISDAVSMFYLVSQSLRTGEPLHAAQYKNLWDRLFYHGCTAGNVLTDVDAHNQSKKAHRQSIMSYEYMFYASAVVAVLHMSHSLNELRTVVAGLCGEVPLEGFEQWRDEYDRSHALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1W2</accession>
    <name>A0A2G8S1W2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_10909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1W2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1W2"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL27756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="393" mass="42918" checksum="BC0CED987CAAB43A" modified="2018-01-31" version="1">MARNVFSVPIFFIVFRETLEAAIIISVLLSLVEQIINQDPALLPGVVPPTAPTSAPEQDKDAAPHEKSSSSNSNEGLPAPPELPSSEEPGQLNTKRILRKMRIHIFVGAFLGLFIALAIGAAFIAVWFTQASNLWAKSGELWEGIFELIASIIIIIMGIGMLKMDRAKAKWRVKLQRAFAGKAEDRGSKTGKYVLFILPLITVLRMEAVIFVGGVSLGQPATSIPIATIVGLVCGLVCGYLIYAFASRTTLTVFMVVMTNFLILIGAGLFSKAIWAFQQNAFNTLLGVDVDDSGGDGPGSFNVRGNVWHLDCCNPENNFDSDGWTIFSAIFGWTNSATIGSVLAYVFYWLAVIAALVYNKYREGRTTLMGRESAMGRKRRERKEAREAGETEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2B9</accession>
    <name>A0A2G8S2B9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2B9"/>
    <dbReference type="OrthoDB" id="2763045at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="649" mass="71941" checksum="94662A9392052F80" modified="2018-01-31" version="1">MDGTVTSPFHISLFCIGEENPRASFKLPLIIEFLVLSFRQRRSEFVAMASSGSLNVATSLDIGRPQMHRAIPRLDLDVLQAICSSIAGVHDLLSVAQTCSLMWRIATREVLRTHTIHLTSSKAIRSFHMFILNHKATHAHHVRSLAISGSSTWYTGPPLCFDDAAADFLMDILDCTVKLDSLHLSLTSQSLRVDPARIAVVFAGLSSLTSLSLKDPGQRWAHYALDALPVQAPLRTLTVHAERKLVIQPVLEPGPYFRTFLRFSISSTLTSLRLDQAPIYDDSSFPHLPQFHSVRSLAITEPLERAPRLAALLHLFPSLDGTLYLRQSFRTGMQLFIDPSASDDAREQNRRAQDVFRWAGLDRLDCNAEIAGVLALQCPVRHLTIDRFDLKAVEAVRPKHLVVASLLLPFRAPGALADTSRSPLPDTSRRHLVVPFKGFFERKYAIPAPGPQRGHSIRESLLPSYTLQVELILTSSPSLMFVSPGSALYAQERLVQTILLFSSATHVRLVFYYDKKGPSEDKLERFMRDVRARASESGGAQLQFAPPPRLLAACPRLRYFFVTAAGGDSTTTNTPAAIPSERCWNHARAWRVVEPGEGGQSRVGGGSDEPAGAMPIVEELCDSAVRRIIEAEDLGLPEEWERKLEACRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2S3</accession>
    <name>A0A2G8S2S3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000029">
        <property type="protein sequence ID" value="PIL28051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2S3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2S3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="15381" checksum="466E53507427B079" modified="2018-01-31" version="1">MHASPPRTHQAAGQHQALENPLRGGGEAAAGIQGILIMSRLPALEAVGVRPEATVLSYASGAGYTGWTDVAERYGAPCFYPYPPRELALALARPRGGAHGAAPRRDVPSVTLRSGDVVAPEGRRCWDGRREYLGAEGRAGPGLYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S308</accession>
    <name>A0A2G8S308_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S308"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="58" mass="6253" checksum="B7871D9C4945039B" modified="2018-01-31" version="1">MRMGVGDDAAAAISLVLDTLSASGWDCLPNLWHIGLQYYSCGPEDALGHLERGTFPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S393</accession>
    <name>A0A2G8S393_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S393"/>
    <dbReference type="OrthoDB" id="2742161at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="221"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1092" mass="123392" checksum="6F1DC958C1EDC685" modified="2018-01-31" version="1">MAPPAYDPDTPRVDPFAAARNHPTMPGVPSISSSTSRPVVGRIESPNPNSVDPFGAARNYPGAVPSILNPQYNPALENYLRAQAQTDLSSHLHALPVTSKAERRLDDHHNEGAPPAKKAKLNNTIPVGSRLEAFLKCAIVAQKELLAREACPSLPSACPGSCKKDFSPPYYRCFDCFHPPTVCEDCIIRDHIHNPFHRIEVWDPALRFWQRRSLGTLKKFVLNLGHGGNPCPVTTKDPRPMTLIHGQGIAHMKVLFCACPEAGTKAAVPDMSQLLRFGLFPGSWDVPRSAFSINGLRDYHLLSLQCQITALDYMRFLQRSTDNVVPDDSKDRSRELNNTMREFMFLRATRRAGIQPTQGLPAGSLGVLCPACPQPYKNMDPADQEKRPEEEKYLDMFFHTVDGNFHSSQKMKPMDPSDFSLTNAAGYYAEQKEFSHFQKEFKPPKKEPTTCHKFGAMGYSRFGGRISGTVGLSCARHMFLLPCGSVDLPRGEAFAYVDYCMCSGLAPYFTLCRHCSGYDINCQYRIHFKARIKELQEQFPSLSTFRILFFPYTLPAIGKFHAPAHTSSCRTAYSYNFLPGVGMTDGEALERIWSVFNALASRTKEMSSGHRHDVINDFHSDMNVRRVHAMPTTLSERYARAIEHKERTADYLAALEDSIDDDAKLARWQRRVDEWIEKILHREEEVSLDETPYEIGQEFKKTLTDRELLAKITQERSVTTKSAIGLLSVIQDGLSLQQERQRLLDRLNTESESPKGGDLSERCQTFLTDAARWHVLVDAYLTPLIEDAVRQLTLRAAATGESLDSRGPDFPLRDASQDTEDAAQGLPRGRSPRNLTEACLEITDIVLPLPSSYVKDLVELPSMSEPVAIERNLRQAAADHALEDVRTALIGVGYLQVEKKSKQRKTHTTRAQGKIQTAQREADKAAGEYRRHRAALLALGMESSDPRYQMLTPRDVVPFSMTSDRTTVGQSRQRTSWIWENFVFATPEEGEGNFTDFHEEARRVHWSRSSATHTRWCEEVELLKEEMRRTVRLFHYYRYQWDTTTRREEEAGNFGAAAYARKQAHRYVRLLALCAENFRGAFEVDALLAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3A1</accession>
    <name>A0A2G8S3A1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3A1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3A1"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31086" checksum="408270A9B7B21D9F" modified="2018-01-31" version="1">MSDIKRITLYAAVDSPFPHRVRLALEEAKATYDIIWIDLVGKPEWYEKKVYPGEGRADAPPPPSPRTQVPYLVYGGPKLSPDEAPSGDAVGIPDSLVILEFLADLFPGARLLPADPVQRAHARLFASQFVEKRLLPAWLPSIFMGAPADGLFAALDELQRRLPPADSEGKGKGTFLFGEGWSIADAAVVPILLRMEHVWRLRPFTLGEGEADKALGTWNSARFERLRRYVADNKERESVKKTWDEADVERHFARRIDRIKRTGVINSDIRVPVPAAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4C2</accession>
    <name>A0A2G8S4C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4C2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="116" mass="12175" checksum="B66884631D0C395C" modified="2018-01-31" version="1">MYTARSSMCSARRALVSAESGNSSTGKQFQFTSQPAMPSTRRNSDGDRGKGAGGKGGVLTVLGRVRVSPPIARRLLQHTRPSRHPGTPFACIRPLSETTARVVAGPGHTAGCARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4X6</accession>
    <name>A0A2G8S4X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4X6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4X6"/>
    <dbReference type="OrthoDB" id="2729416at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="249" mass="28795" checksum="4C0BFA4F89D181EC" modified="2018-01-31" version="1">MLNELKLNHVVLQPPHIQLTFDALQVSMPQPVPADADPRLFWNGQYLLEEDPDHPANLSEAAQEAQEAKWLALMKNRGPLKKLPRKMVPKDGSKPPLYHYGIPFTDRYMFEYAKRHGLTLELSPETSEYFDGSPVLDFSKLTPEQEQDADLMNQLLMIASLLAQCDMEKRQCGMKLHVARPFSSEWNGMVSLWSNYDWHDRYSKEVGSCARFQNIVAKLKEAMYEGGQENDIEWWYEWDNPVGLFSSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5C6</accession>
    <name>A0A2G8S5C6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_08792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5C6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5C6"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013930152" description="Peptidase A1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="92"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL28748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="199" mass="21075" checksum="6988B0B75C37B3B5" modified="2018-01-31" version="1">MARLSALLAIAFAAVSISAKPIVVRDLPVTLPIARRFNLTGANNILKSDQARAKVLKARSQASKEPPASVSAVSKLFARDVDVAVTNGAVIYTASVGVGTPPTSYDLIIDTGSSNTWVGAGKAYVETSTSVDTGDEVEVIYGSGLFFGEEFVDTVTIGDLVIENQARQASGKSAPCQRRDKVGTYTHLCTQFDKDFGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5J7</accession>
    <name>A0A2G8S5J7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5J7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="183" mass="19633" checksum="654B301A9121C305" modified="2018-01-31" version="1">MTPSCARKGCCCCFSGAMNCEMELCSSARPSSTLPTALSTDILPGPSVPGEDTTTDAPVRDVAALPDRVRAALPLPLRLRLVRGITSLSLRAGSSPAECATSHLSPFISRSRRSRSRSSTSTLCTSSARSSAWRSVRLRRYDERRLYLSTCCCRASRRSCAVAFSSASTFRARSSRTGVPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5V6</accession>
    <name>A0A2G8S5V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5V6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5V6"/>
    <dbReference type="OrthoDB" id="843225at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23659">
        <property type="entry name" value="USP_At3g01520-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47815:SF1">
        <property type="entry name" value="UNIVERSAL STRESS PROTEIN A FAMILY PROTEIN C25B2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UspA" evidence="2">
        <location>
            <begin position="144"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="328" mass="35653" checksum="79FF0B8B81DEEEC1" modified="2018-01-31" version="1">MSLPAVTSPDRPQHIPLPPPLRSAMKRSSSRPTTPNQHPISPPFSPPLGPVPLSPPAPSISLSTHAGSVSVAPSIYSSTHPSSSSSMVAVNGPHPSSSPVIAATGYQPKVSFDTLENPQASMFSYTLHVQSEGYSRTRSTRVFLCASSPDESGTHALEWCLESLVQDGDELVVFRGIDHDDFEKDHDQYRDDARELMRIIQEKCVEYDAERKLSIIVECIAGKVTQTIDRLIALYRPDSLVVGTRGQRSVMQAWAGAFGAPGVGSVSKYCLSHSPVPVIVIRPESKVRKTMAKRRADPKRGQHFDTSTTVKTNNNGNLSVPMFSALTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S656</accession>
    <name>A0A2G8S656_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S656"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="17296" checksum="AF7A2E05C3777800" modified="2018-01-31" version="1">MYRQAADHAGGHDGVDHYHYYGYDDLSAFTKVHESRSAMFKVLDSLWLVLTSQLVSRRSGDQDLTTEVRTDNTTGHEPTAAYYCKWFPIAIGMTMSSIEQEWPAQRAPPDNLDHCGDMCSHVALYALHAVMMHLAASPEVSPRCTARASYNLPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S684</accession>
    <name>A0A2G8S684_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_09293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S684"/>
    <dbReference type="STRING" id="1077348.A0A2G8S684"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL29244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="552" mass="62923" checksum="D5A256A200880E54" modified="2018-01-31" version="1">MDISLVLHGLSGALVALLAAVLWKLGPYLLAPFRSSLLNLPGPPSRRWLLGSLKDIYDSDGEVILDEWIEQYGPTVMFRGFLNTPRLFTTDTRALNHILTHSAEYQKPEEARRSLAHILGRGVLFKEGDQHRQQRRVLNPAFGPSQIRELTDIFVRKSMELRDLWTSTISVQGHVARVDIQKDLSKMTLDVIGLAGFNYDFDSLNPEGKPNKLGQAFQDIFDVPDRFPLLLLLRNFFPILRFIHNKQSRKVEEAQAVMQRIGMQLIQEKKAEITREHAEKSEQEKSFDDIERRDLRSRDLLTLLLKANMASDIPESQRLSDEDVLAQVPTFLVAGHETTSTATTWCLFALTQNPRVKKKLRDELLAVETDTPTMEELNALPYLDMVIRESLRLYAPIPTTIRVPIKDDVIPVNEPFTDRNGEVQDSIRINKGSHVIIPLQTLNRLRSVWGEDSYEFKPERWESPPEATSNIPGVWGHLLTFLGGPRACIGYRFSLVEMKALVFTLVRAFEFELAVPPSDIIRRATIVTRPLLRSAPEQGSQMPLYIKPYKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6D4</accession>
    <name>A0A2G8S6D4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6D4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6D4"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="116"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="449" mass="51794" checksum="639A1256A4A714DD" modified="2018-01-31" version="1">MAEVSSSDYTKGHWSAPPAQGSQALSWLVRDGPEYEERKKRSQFVPPSVSIKDVHAAVPRHLFERNTAKGLFYVARTVGLSVFFYKFATQIDEFSWSTAVALGLGPTGRWLISWSFWILFWFWQSVAFAGFWTLGHECGHESVSPYGSLNHVIGICLHTFLLTPYFAWRATHRTHHKGANNLARDETYHPMTRKTLKLPGAAHATKMDYKDLIEETPLYTLFKLFVRQFLGFQLYLVHNRKGNPKYPPGTSHYKPSSKLFKPQDKNYIIISDIAIGCMLLNLAVWIYQIGFHAVWSLYFVPWLWAHNWLVMFTYLQHSDPTVPYYREKSWTFARGALATVDRPVFGWIGVFFWNNIAHHHVAHHFFVTIPFYNLERVTEAIKPVLGDSYCYDSTPTFYALWRSFTQCTFIEDEGDVVFFKNQRGEALRDCPAPQAGKEGEDEAFKLAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6P8</accession>
    <name>A0A2G8S6P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6P8"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="265"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="703" mass="78532" checksum="63CC09A29CC9C06A" modified="2018-01-31" version="1">MRLLDTKTGQFVNHDPRTDIYAILSHTWVPEGEQTYQELQAIQRDYDSNGFSRLAYPPQVVSARLAPTTTSTQRPAATNYKIPQPASIWDDPKLSPKIRLACETAREAGFRYLWIDSCCIDKMNSAEWSEAINSMYAWYRDAKICFAFLSDVPTSPPSRDSRFRTSRWFTRGWTLQELLAPREVVFLSTEWKYLGTRDDLAPLLQTITGIDRGVLRQEVSLDAVSVAKRMSWASTRETTRLEDEAYSLLGIFDLHMSTMYGEGRRAFRRLQEEILKRIPDQSLFAWGNPGIGPVPATFLPCVADLLESTPAEAIGQAAASTSGRGAPFLSSVGRPMFVDARSMFATSPRDFYASGSIAPFVDHDSFAALLGGIDIPVQDYSPSPYGTRTQLPLLSLSNKLGFSPEDYDFCIAILACTDQRYGDSRLLGRLCVVQRYQSPSSKLHRLYATGLLQANLNGLCSLFVLPHAQVLKQQDLLRHINVQTVYLPNPDRELPPHKDEDFPYGPVRDLGDEGITKVTVQFPQWAVDRLRAQGYVVNVSPRTHDTKTGALIALSKGPNTLHIIYQYSVSKLHRVGVIDFIARIYRIQPESVPHASLSRNSRHAGLARTMATLYTSVTLRVRYGQRSANDITSVSFLDGSTVVVRVDLELVSAACYHLKFSVESENSSSEDEATVEADDSVDPRSDEGRFVLRTGVIRMGSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6R9</accession>
    <name>A0A2G8S6R9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6R9"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013936810" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="34716" checksum="B1AE670348A51C86" modified="2018-01-31" version="1">MVQLSSALLLTVSALSLHARGAPIIHKRIAQVIADSTALWEKACLAAGGAEQCNPVSVTAFTTLLAAAGPCDQQDSADAMIDLAKTLNSDADMIKFAQIFAQQPRNTPNSVAVPYCQSAPKNSELDGLFQCQFQGANQQTFVGGLALGAAGTIPFGLTAPLSPLGACPANPAGPIADGTQLTDITQDPGLQNIPSESDCTDNSVTVTSTVTAAAATSTADAATTTEASVTTTSAAAAASTASTSTSTSTASSSNFQLQNALDAQKLNAQFATLTSDATCTDGDQACIDGGFAMCVSGKFVSMGCAATTQCFALPLVNKAGTSLACTTQADAAARIAAPGATGGITGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S747</accession>
    <name>A0A2G8S747_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S747"/>
    <dbReference type="OrthoDB" id="3174319at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="429" mass="45862" checksum="9CCADB798ECCB17B" modified="2018-01-31" version="1">MSQPADVQSPSPSAVFDADLFQTSVLEVQQDFAIVGLLCALYVWALTRRKGSGHGRQRQPNSIILCLTIFALFASTTAYMVTCMLSCQSIFLKSFISSGYALWSKSSNADVTAFSDGPLKQTPGKDYTMIHSCASTAAITTNITLGDAIVCWRASVVWFQTRTVRATLLALLLATFVLGATDTAWGCRAPYRVAPLTIYSFVPLGTSPGHAGLPLGIAACALSLATNLLATLLVAYKAWESRRRLWGHFVVGGTRAQVQQLLALLVESGAVYCALWGVVVAFQVGEHGVGHPASTPVTDTTDGFLNVFNVFMSGGLVPLIHSQAHRDPAPHGQAIYPAFIIVLVALNRSPIDRGFSQQNADSVPTPHISAMVGMASVHVDVPSENSASASDAPVIDGRDKLRPRGIHNSQDTSARTSLEDLEQKAEEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S820</accession>
    <name>A0A2G8S820_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S820"/>
    <dbReference type="STRING" id="1077348.A0A2G8S820"/>
    <dbReference type="OrthoDB" id="406833at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23808">
        <property type="entry name" value="UBCc_UBE2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="139" mass="15088" checksum="6EDBA358044460F7" modified="2018-01-31" version="1">MAVSTRRLQKELADIKKEGTPVGIELLSADDFSTWYLTVEVLGETVYQGEKFALKFRFDGQYPISAPAVQFVVDGSYHAPIHPHVYSNGHICASILGSEWSPVLSVVAVCVTIQSMLASCKVCPSVHPICPSCACQCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9N4</accession>
    <name>A0A2G8S9N4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S9N4"/>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="77"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="932"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1347"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="712"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1326"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1363"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1418"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="534"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1205"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="771"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1326"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1369"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1477"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1486" mass="165816" checksum="AD7A9B7EA63A8CD3" modified="2018-01-31" version="1">METLFGKRRNRPRQSSVVAQDASERLRPLSGASVATTRSDSTRGSRYAASVSPFEPHHHHLSNLYKHTSPTEEFNFLRPDNDEEIEMLFENIMRMRGLDDIPHLSIDQKWHIVYNDEQMRWGEERKREEQARRQNDSGQPPAFVEGTPEWYIKRFMDRTITPKQASSLQVSLRSKEMSWFRHFVDLQGTSVLGQALQNISRKGVQRRKEDIELENEVAKCLKQILNHNFAANDALNHPMILTQIASALNTPHLPTRKILLDLLCFLEYYNDGQVHNLVVSALEALSAVNNEAGSPYAYWFKSLEIALAGRGKMGTLVGASDEVKRHGGIDPSLNDYALSNLFFINSIMTHIDDLDIRVHHRSQMEAAGLQRIVEHCQSFGVAVIDKQLEMLQQALDEDESKLKERIDQAILRDLANPEDVYNALRAKTADSRAKDHFLSIMQHMLLIREEGPALAHYYQLIDSLVADIVLDKKLVGAEQRLGHSVERIIAQFNEADRQQQLEDDLALANASTLRLRLEKEALEDEVAQGEGGLVGSLKSKVARLEEKLAISRENTQKLQGQMEAQKAGYEEQIAQLEAQIMELFRMLKEVSKGVGKIIDHANAGGMDRKTLIDTLEKHFQRDKTISILEGRSGKKLRDGHEGSEGGDGTEEEETPKKSGSLRRNQPSTRGRRAPRMDRISEAQNGHTSQFMDADDEIEQEQIQQQMVEGAMNNVHHSASSSPRSARTPSRRNKNLPRTPLGSHFVPDSDDHNVSLAETTDEFDGDSELRRSGSTHSISSNQTTEATSVSSNISIDHHGKNSPDQPQSLAEQLRRHLTERGRPPSMPSPLHSPIPEGPAPPLPPPPPPPPGASASPPPPPPPPPPPPPPPPPPPGAKIPGPPPPPPPPPPPPGAPPPPPPPPGKIPLAPPSAPGSARTSLLGANISNLLAARKDISITPSTKMKQLQWDKIPMQQAEKTVFKEPSNEDEWVKKLQLDGVWTEMEEDFKAKQLVINLMAKQKRAELKSVLDPQTKKRVEILIQTVKKFSPEELAFRIRDFDQEVCSQLFLSELKRVLPNPEQVGKLNVYRNADPEELASLHPSDRLMVQLLKINRLAPRIEGMLYKCVFDETWGLLDDSARKLSQAGKALLDAKNFKELLSLILLIGNYMNGTGVKGGAFGFRVSSINKLVDTKSLHNTTLLHFLERTVAKHFPDMETFLDELAAPAEAYRVNLQEVRKSLSELREGLKKIRKELTDNFSDMDINDKYGKQMWSFVGKATSQLEDLVDDVNHADNTFSEVVKYYGEDEKNLNSAEFYGIFKTFVTSYKKCRSENLSIAEEREAVEKRRQAAEESRANRAKLKESSQEANEEDNAALDNLLEKLRNGDSVGRKARRARKSTATRQTAAPLTLNTDILLTTKSGDETVDIARDMLMRLKSDGFDALTPTTPTAPNMRRSRRKRDSEGVAALAALGESISPGGPSREDSESSTAPSIILDSIEEHPSPATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9T0</accession>
    <name>A0A2G8S9T0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07216</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9T0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9T0"/>
    <dbReference type="OrthoDB" id="2757990at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="327" mass="36349" checksum="FE032B48397BC48C" modified="2018-01-31" version="1">MALSNHLIHDWQFQDRLMSREPALRSCSGGCGKTRDNAQLRKLLCRTPGDVTASPTPTTAGELPTQFSSLGSESPSFASPLATALQEFSAAHEWAFRSLAKAFVLLRGSIDSWSQNPALKNLNFFLSPTAISGARGRRGDPASTFRLTSYSFTPLDEILALSADGYLARQKEVHKMMEDMWRGHPDYVGLLHMMFIPNGVDNCFGRYIPLFRPVTLQGPSEITSLRDDERLRKNILESIVLVSSGSINAGIPFRPVEGSGPRRDMMVALPGKFVRGENASWSWTALFSRWDDYRRGEHRHLDDLINMVPVLRTSSSPGYTIGAFNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA63</accession>
    <name>A0A2G8SA63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_07333</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA63"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA63"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL30631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="185" mass="20010" checksum="7F81FF27970D361D" modified="2018-01-31" version="1">MSASTDVAKWKHLPPPPGFAASVSSSKSSGKTVAAATASYEELKSKRAWDLAFSPAKSLPMQAFMLYMSGGGVQIFSMGIVFMLLSSPFKNLAGINTAFASFAPASSPPKALTTLSLQKLAYFFCNLLTLALGLWKCRSMGLLPTGTGDWLAFETRGQARTPISRYPYRFLMLPFVLKPPEILLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAD7</accession>
    <name>A0A2G8SAD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAD7"/>
    <dbReference type="OrthoDB" id="10355321at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="166" mass="18576" checksum="D0AC6617D8FF9DAF" modified="2018-01-31" version="1">MAQSSHHATHPSKETVSALSDVAFAEILAKRLASLSAEQEAANSRLGILSCLAAEVLKEDFPEPTDEEAPASSELSWEEDTEDLMDEDDDDDDDAEHTCPRFKSGERVRVPSKSSPEGWRYLHIADLTVFPPKHSPVCCTYPVLMQYKPRIVRYLDSTTLTRVDPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAT7</accession>
    <name>A0A2G8SAT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_07046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAT7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAT7"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL30877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="448" mass="48021" checksum="C4DB47DCFB988E2D" modified="2018-01-31" version="1">MIVPVIPFRLQDLGYADVSSLVGWLLFAYSAALVISTPPIAYLSERHKNRRIPLLCGLVALIGSQILLMEAPTYWLMALARVAQGVSGSVIWVVGLALICDTVPEAIVGKQLGLAMIGMSLGSGSSTTSAAFRHFLVGPPISGALDNRFGFRGPFIFGVIVTGVEFICRLLIIERKEAARWDASTSALVESNHASREHVNAYGATNQAVKNEGPGPATEIATQPQTQNTGTDTDTVQVAAIQPTEATETQPQAQAHLTVMGLLLKMVKSPRAMAPVFLSFAYGIIITAQEPALPLYLQSTYNFDVSKIGLVYIAAIVPSFISFKGSIVYFLAMFACINFFFAAVISPITAELAAVTRSMDGVGYGHVYGAFNIAYGIGSAVGPVIGGQLYDHTSNGWMAIAFFDLGMIAACTLITACFLGDPTVLRTMMIRLRACRRLRERRRGVVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBF2</accession>
    <name>A0A2G8SBF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBF2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59730" checksum="E4F0911A0DF014FF" modified="2018-01-31" version="1">MHRFEADLLEQPRLNFDVLRLVCNSLTEIPDILSFALTCSAFAVFAFQRRLRMSPINLSNDEVVDSFHRFIFADKAARAPYIYGLKLPSMHRLRRKESPGSWLQAMHDQLVSILEAAVHLEYMYFPTNLDLDPVLAAAANMTSLRELRIVFEALASFPKWSPWKLLGTFRSPLRSLRIDSSNDSARNEGFSVKLIHDYLANFAPTLEVLEAHSIDFDDFPSPVMTQFTALRSFTIHTVHNFNQSTMEVLLQLFLNLNDTLALGFLGVMGSMEHDHRALREWLHIAVFRSYGRVLLEPVLRDSCPRFLHISLQDIDILHNLDDLFLNTSSEEVDALTHLVVFVDVEVRGSWHAESVRIPSWAQFRDKLIDSVKHLRLTHLRIVFHYAIWWPQQRAIPTHSLTPEQIAVYIADKGDLHTVATRIFDAMPTAQYIFLTTCGHSYPDRHLNEKRTDGLTVLNKWHASKAWRRAAHPLAEGRRELSNAKASPVELSGEATEKIIAQEELYLSSDEEVCTKFVFANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBH8</accession>
    <name>A0A2G8SBH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBH8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="37518" checksum="4D82F90B0A3B3065" modified="2018-01-31" version="1">MSSSSRTRDGATDAEPATKPTTCSGTDLRLIESIKPLRLTHLCIVFHSAVDQYARRPPQDEDLMKTACGVDLRPAATSYTNVVPQCSNRGPLFLQRTFDGWLSSKAWRVVHGVDSELRSLGLDAGLGSCVELSRGAAERIIDEEELELSLHDEWRVPKLSCPAGTGANQRVLEKVLQNTDGARPSYVCRYEDARRWGEMDLRPAATQLAGAIPTLQYIFLTTGSCGCTHRLVPHDPWGLSTERQTPDKWFSSKEWQVVHCHAHDSGDRPSNVRAGAACQCTVTELSGSAAAKIVNEEELELSPGEVVGGDPVPVPPDRLCIPKLTSTRTTPQNELQKFGTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC54</accession>
    <name>A0A2G8SC54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC54"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="549"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="92736" checksum="F3CFFAF3CCFAFAA1" modified="2018-01-31" version="1">MSEQDEYDAYFVPFTLNYEDLDAIQAAETRALSPKHATEHTPELHSNNSPSSHTPPSSDEFDAYDLSEFSAEDFVQIDKLVLSVHPPPLPTIPERPDTTVSRDSQSPLGRGSPTGGDGGVKNGGPSIEIALERNRNADSPRPLKDSWIKRTKRSPYEQFRSWNRLLSVTDITGPSWCEVQFDYGLRQKRHKKLAERPKSFVTAEGKTITVAHQVAAVNARTVTRGKSVHKVLEREIQPEAVKVEITTNEERWGLRYLQLSWKREMPVFGLIHDQIVTGIIDEVVRHPLSTSPTSEDPLLRGPFMSPNKRPPSDSTPPSPEGPSLKKICAEPSGGPSQITSFFSPTTCKGNTAETTIKVDLEEPMAQVPLQRELSEATDSPTPDTIRYSLHLSDTKTRVHPTLPPDEDSFAGRIQLMLYHRLLSNALSIAQPDIASAQPLDFDAFWKKANVDPTRRFSDSFLLQTGLPDAGRTPQEGTSIDNAIDLSGIHCLNDLTRAWRNTVEALNAARVDNTLTIVYRSQPGRAGAPVTSPDAKGKNKDQGADNTAEPAAAASTPASSTLSLSDQEARDVAAAIQASISDIQPGAGGDGDLARAIFESLRDAIRSGQTSEGGDLGILTHPFGPPISEAMSTLEGGSSGQAQGGLGMVMGAGGGGDAERPRAHVAAADGLAEDPQLAWALQESLLARLKETPALKEAISEAVASSRADAPAADVEEEAPEEDGGESGVAVGTLLSRAATEEPEGVSKTAPTSPPAPRVEDEDEDEAMITAAELETEAKIIGTKEFELDDELLDDYLESVLAWWYGKRQPQGVDIELTRRCVTCEYRDGCEWREKKAQEALQKYQDRSMPGAAAEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCK7</accession>
    <name>A0A2G8SCK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06184</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCK7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCK7"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="195" mass="22189" checksum="E00DCE0E82DB9F33" modified="2018-01-31" version="1">MTIGTPEERVAAMQDHHHKRCEKWKGELMTYSPAVVFMLKHLKQSGADVTSNDIVCAPCDFARAGGFSPAGVIVLCQDKFMSKGHMEDTMVHELVHMYDHAKFKVDWDNLRHHACSEIRANSLSGDCRWSREFRRGFVSFSKQHQAGLADECVRRRAVLSVRANPACPDQATAERAVNEVWESCFNDTRPFDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCT2</accession>
    <name>A0A2G8SCT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06263</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCT2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCT2"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="59" mass="6796" checksum="FCE6E0986AC89D24" modified="2018-01-31" version="1">MPPPPIQVFLTTIASQPALRQRQEYVLRVLQVKKAQFTSYDLASDEDAKKLWRRKAPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF03</accession>
    <name>A0A2G8SF03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05601</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF03"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF03"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="513" mass="56092" checksum="0207E7EE8A686514" modified="2018-01-31" version="1">MSTLTYTQLEEIPKIHAAAQAAFRSGRTKSVEFRKAQIVQVGYMLQDNEDRFKEALHSDLGRPHQETELLDFNPTYAEVKVAYDNVEKWIKPQNAPFGINWFAMKPRLTAEPKGVVLVISAFNVPVFLTMTPLISAIAGGNGCVLKPSEQTPAFSALVAELVPKYLDPELYHVINGGVPETTKILELPWDHIVYIGNARVGRIVATAAAQHLTPVTLELGGKNPVVVDPRADVALTARRLLWGRFSNAGQICVAPEYVLVPAHFQDALVGALKDAYAAFYPDGPATSDSFSRIVTSAHAARIKRMLDATEGTVVVGGDADVEKRYVAPTIVRDVKEGDSLLSDEIFGPVLTLVPVKDEDEAIAFIRAREHPLAVYVFTPDAAFERKVFDNTMSGAAVTNETVISAGVPGLPVGGVGSSGYGYYTGKQGFEEVIHWRVSLKNPGWVDRLVLHFRFPPYRVCVFAEGLPEVHQGDERGAAPRPGKAGKRWGFWLLFALIGVSSVVLTRVKRPLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF94</accession>
    <name>A0A2G8SF94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_05493</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF94"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF94"/>
    <dbReference type="OrthoDB" id="1934695at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL32248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="556" mass="63244" checksum="FCB66608D0FF0043" modified="2018-01-31" version="1">MTQYVAIAVLVLTSWVFLRLRGRKSVLANLPGPPVTSWFFGNLQEFFDRHCWDYRTQYERQYGRLSKLNALFGGTWIHVWDTKALHAIFVKDQDHYLEPMLTMQILIGPGLFATEGEQHRRQRRMLNPVFSTRHLRGMIPLFYSVTGQVCDAIAQRIRRHSGGRGNTAEVDMLSWMGRTTLEIIGQVGFGSTFDDFTSDEPDEFRTAIKSFFPEMMKSILIRVFLPILVHIGTPAFRRRVVELIPLESVQRIRHISDVLHERSVRIFAEKKAALAKGDEALKHEIGEGQDIMSILLRENVMASREDKLPDDELIAQIALRAEFLQTVEAEGDGATLDFDRLMELPYLEAVCRESFRVYPSVTCLFREATKDMILPLSEPIRMLDGSFISSLPAPKGTRLITNLAACNVDPVLWGLDASEWKPGRWLEPLPKAVEEARVPGIYSHMYVLFIRFPVQEPRSNAGGFAPQDDVPKREQGLHVSLKCLSREMQQADTLCRSGFKFAQIELKVVLFVLLQRFRFEPTGEPIAWNSAPAQYPTVGKVSEDPALPLKVTLLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFI2</accession>
    <name>A0A2G8SFI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_05232</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFI2"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013426950" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="105"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL32529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="603" mass="64880" checksum="53AABDB1507BE575" modified="2018-01-31" version="1">MQLSATFFRSVYLAVTLSSVVSAAPFSGSVKLRSLQTRAVSSGLTVESFHPESSFETFGVDGVDRPLSKRADFDIQDATVSFIESKTGFKADSVNFRTSFSGDVTQHAYVRQQISGIPVANAVANIAFNANKKVVSFGHSFVKAPSAKTIPKTEPTISAQDAIAKAESALAGKYNSHPTTLEWVAKKDGSLALAHVVQVQNDEQHEWFEAFVDAHTGDVIQLTDFVAKASYRVLPISKQTLLEGFETLNDPANLNASPKGWNFNGTTATNDTSGNNAFAYKFSDSGTTKQSSSGQNFIFTQDPTADPTTDSNVAAAVTNAFYIVNSVHDIAYLYGFTEAAYNFQNDNFGKGGAGGDAVRASIQNMQGLDNAWFATPPDGQPGQMAMFLWNDAHTGPERDGALENDVPVHENTHGISNRLTGGGTGRCLQTDESAGMGEGWSDAMAEWTEQKDAEVRDYVIGPYVTNNPAGIRSHPYSTNATTNPLRYSTVASRTEVHDIGEVWANMLHNVYAALVGKLGFDANAHTDASGSGGNTVWLHLFIDSFSIQPCNPTFTDARDAWIQADANRYHGQHNCTLWNAFASRGLGVDAKNYTDDSTVPAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFK8</accession>
    <name>A0A2G8SFK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_05624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFK8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFK8"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF42">
        <property type="entry name" value="ZINC FINGER, CCHC-TYPE, RETROTRANSPOSON GAG DOMAIN, ASPARTIC PEPTIDASE DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL32378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="293" mass="31826" checksum="BB3A5FED6186050B" modified="2018-01-31" version="1">MPSSTMSNAGTTPAPPQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLASGTQPWADFAAFEMAFKAHFCAADDKEAAIAELVKLCKGQHKIGTVQDYTVKFNAIAARTSFSAEDKHERYRTGLPYKIKDILATSGHDTSSITKIQAVALTMDQNLLVCEEEQPKQFSGGWRKKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSGETTDLAALRAELKEIKERLSAVSVNETKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFP8</accession>
    <name>A0A2G8SFP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFP8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFP8"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12213" checksum="46790282D65861F1" modified="2018-01-31" version="1">MMMFNSLVPPMSHGMHASFSSPHHMHSGLDVKAPTLIHADEDAYASLPPTPTSPFDLAPPHGGWSSHHHHHPLAPPAQDCGRGMYGMHGGMGGGLAGDVAIAGTGQYMNSFMGYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGA3</accession>
    <name>A0A2G8SGA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGA3"/>
    <dbReference type="OrthoDB" id="2733439at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="43791" checksum="FA6200B5E41C8CAC" modified="2018-01-31" version="1">MPANMEDIMPFLFCLSPTIRTFTLEFECGFAVKLEDLDFLLPFLTFISDPPEYAIDPILYLLITSEGDAEEIIHHLRKSARLMMLEELDLTKMYYRIEHASVAALSRLPSLRTLKLELAVRGSATPPFTFASFESLRHLSLDPMPLPTLSTVLATGGLRTTPLRSVDLRCFLNSCLSFTDFQHYLALIRAALPDTLEALRFGLDYNKLAEPPLPLAALFAPFLSLNHLTSFDLSLRWGYIPHVADDDLRALADAWPRLEMLHVWVWEMCYPRSSDARPPTIAGLVDLAEACPRLRRVMLPALDVSMLPETSALPVGGYRVVRFLDMCALVKDEGVAVEDVARILDKLFPCLEAYPCDWEATHPQEKSWAKVQDAMREMQTARRGIGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGC7</accession>
    <name>A0A2G8SGC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGC7"/>
    <dbReference type="OrthoDB" id="2756950at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="246" mass="27304" checksum="B1CF5C2F914D7FA5" modified="2018-01-31" version="1">MSAIQVSPQEMADMNIWLARMIVLLVLPPVAIFISCQLYLVDLNSFRLVKHDLGIELLVIVITWWYHYQSYRVRKGGIDLGQSISSLLVYNGSIYFLFLASLYTIDIIFQTASVPESASYIDGFLELFYDPLSSILVCRFMLSLRRFDASIVSATNSGIGSRVRDHTASTLLQFGAQPSESLPAFITSFAHPVHVDWSLSEAEADAIVDDGSESREMDAMATRLETLPSGCYSDPMSEGQPAKPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHB6</accession>
    <name>A0A2G8SHB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHB6"/>
    <dbReference type="OrthoDB" id="2751365at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="526" mass="59083" checksum="89D088A054F80BFF" modified="2018-01-31" version="1">MVSFCNGAVSSQLEPISVSNRDRRTYPFTSINTVVGSHLAASEVPRLVEYSNSAGANFFRHPDLVKVMFDHFKKEYHSPRERRDLISFMLISKVTFRYPARILWSRIGRQFVAALQLLDLEVWDNGSHRRLFGPPLLDALEQNKDRLAEHVMWKKFLYYADAIEFVDTNTVFICPGTITLLAHLLPPSDALVFPCLRHLIWTESLTDSNDLLHMLGPSLSVLHLHIYDFFDEQYTSTAFMDWATRMIHAASHLSHNIRVLVIDAMGSLILNPSVLAYFCTLHQLAITQASPNSGQDVMAPPMAFQSLEDLEIVSYHGSKGLLNSLPYVISFMAHSLRMVNLQSIAGSSALDNTSFVENFQPLLSLQQLMEVRIGFMLVDFEFTDRDLITVARAWPNIVEMAFAFSRLRTSPVPRLQTLGLVAAHCRSLKKITLPFLVGPGSGTTFEISAPPSHPLEEIRTHSMTWDKNQSGAITSRLKQAFPSLTGVFSNGSIDDEHELLWAILPPYILSSQVAAYPISVPHADNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHS7</accession>
    <name>A0A2G8SHS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHS7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHS7"/>
    <dbReference type="OrthoDB" id="3046414at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="435" mass="49355" checksum="255A8A97BD635DEB" modified="2018-01-31" version="1">MEINRYLDGLRQGCRQIRSYDERYVPGMAYTQLSPLELLLLGHDAKTVDFFFSSWTPDLIMKLRSLSSSLFFAVEAYASRKWNINTHLRRWFHDVPDFLRKLTACDAVVSGSEAVSFFDRHSFHGHDLDIYVPLHGLLPLGRYLKFYGFAYQATSRSHPLFDAAAMMLPSSLRYPLPPSAQSITHGQRSEGRHASRQDATYTFATFNFVRSVGRNSVRGHHVQLIAVSCDPIEYIINNFHSTGVMNILTGTHALCLFPHLTFVDRVMVTCRDLARYAGWEAPWMSKYRQRGFQVCTAEDTAPECKERFIWRRKVGDRLTWVLPYKRTGLHPKNSVEISCQYAFEVLDTSYDVTPIGAALRVGPRFVYSSISFLGNCKSPLLDTDYQSVELAAAFPHFFYPMSDDDSANSTVGTEVEEDGTETESASENDDGDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIL0</accession>
    <name>A0A2G8SIL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIL0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="37150" checksum="D3F736F03E447CFE" modified="2018-01-31" version="1">MTLDPKMISQVPPLDALVQGDGPSPRAVLDMLEISWCEFNGAKSLFDILRLFSRIRLIRVWSCDVKSGADDADALDLHLSTGPLVESVVLDTMHNDSPSILQSALSMSSLPAGSLTAVRLKITRQTDLEGFLIPCLHGARDHLRTLHLDLDRRLLAAAPGIGLTPWNPLVDCIASCTALEALTFVVEGKNQSRVPYMNYLRDVLPAYARLVSLSPPSVRSITFKVHAGDKTCGYEDEDANFEDEPVDRNFEDYGVKEVLEAIAEGTHWRTMDTELAGQRALARCVFVFYNTEGHPAPEDRDRIASTLQGVLPWLVKRGVLAVETKPPVDSKASLYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIR8</accession>
    <name>A0A2G8SIR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIR8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIR8"/>
    <dbReference type="OrthoDB" id="2754335at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="517" mass="57095" checksum="7B8E0644FDE9C121" modified="2018-01-31" version="1">MSAPPPPTSQCAIGRQLGSPNSTRGRDLTELAPDSPSTHPDVPLRDQFLPKRDPACEQCTTPMTQRHLFDQALEPGRYAYGEIVMINESVHVPIDHILTPYRQKMGLASTSTLSLARSRRKERPGVFLGRRPKGANGTEMMLMATFSGIYKHDDLPRLLRLFCLPISPHCGIGATIEHLHTTPEWQKNHGWLILHPFSSLATVSGRWKWKDEDGTYQKECSFKLDEEVISQLEEIHNRRFKEWNAKCSDKGYLRECLEEYQKFKQKGKNQSKSSVGGSPFVPQTSFEDLAEPAVTSEQDGPQTNENAQSLGLLWESQPLPGNADVEPGPPIDAQLVPSPPHSRRPSVSGRFMFGDAPPLDLDPANLDRHGVGFRREIVERWRRTLSPLVGPRNKLRGIAFEADEWLNKLLDMPGEPFGVPGEVFESDDDWETTSAATTESVHDDAGPVVDETRAVLGGATITLPHVQVGQPSGEPVNELPPSADNDRGSLGEPPTSAPLQAIATSVLEVCNVSNRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ43</accession>
    <name>A0A2G8SJ43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_04362</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ43"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ43"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="6">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="550" mass="58877" checksum="3EDBE9480D226F57" modified="2018-01-31" version="1">MDDRPRKRARVYSHNAADKDVAELWWDAMRSDELLANGLPSLTRSVSRDVSAPGPPSAINDPPRNSSRRKKKKKKETTSTNTMLYHMNNNIRTLRRVRTTHAKFTALNQSLEENGGVAPPPIHDIHEDLDDVVDERPWKPTGAGIDMGGDNAKDCLHWMGNKVLEHAGFQGTSKMALDVLSSVTAEYLQNVGRTIRFLCDKYGNQMTPEEIILHTLFESGITQIGDLERYIKDDVVRYGGRLAELEKKLGNAYREATTEEAWDDEALFRMEGEEEDGEFVMGNFAESFGEDFFGLKELGIADEFGLSSLTVPKRLLKGKKGGIKEDPSAPSDVLVTSAKPLEPPPPFPPPPPFIPLDSNTVDDQIGLLKGFYQSRVAEASAALVAPPPLGQAGPGLPPPLPASGTINGLPAPYPATLPSIPVNPAPVDLSFGAPHLRPTEPAQVVVLPDDAPSLAHTKIGPLGTINKAAPAASTAKKKSKAKPPAPTPGLPPADGDAPPPATPGPLPPPPLMHSSSTGGMSESKKGKGTGTPSKKKAKVEAFPPVVMASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ64</accession>
    <name>A0A2G8SJ64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ64"/>
    <dbReference type="OrthoDB" id="2758769at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="246" mass="26950" checksum="FE4D08601F38ADA7" modified="2018-01-31" version="1">MSSTTLTLTESEVLSHLPAGSRIVSPTAKVFIKHADHRWWNWVNNACTGLSLQPGHDLPKGSLAYLPNELVLSCYVKHPNGSWLNVQPPREAFSPNNAAAPLQIISQTPYKSGAALVDDQVVPFNVLMTAAERGEVADPAGHAFTGDLASPSREKFSIRFGLPFVESSRYKAGQHNLHRAKVPVMRRQLAMDIAKEVRRVMDALEEIHKPLALPGGRQVAFEELVLVDIQRMSHGSLQPTLAVRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJB3</accession>
    <name>A0A2G8SJB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_03565</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJB3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJB3"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="105"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL33859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="168" mass="18564" checksum="08B821AFFD54C309" modified="2018-01-31" version="1">MGKRKAEASSSDEEDDVLLSVPASSPERPLQTARRSGKKAKSKADSDGESEGEEEKPVKKSKAKAKEKVKAAKPPSIKKPKIPALNEDTDEVKTGVTDEGDRFVDLGKKKRATVRMFKGSKLLDIREFYGDEDDLKPGKKGISINQEQWEALKKSSDVIDLFFARLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJI9</accession>
    <name>A0A2G8SJI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJI9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJI9"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="410" mass="44733" checksum="84BFC8503AD72C49" modified="2018-01-31" version="1">MAGTKVILAGGGVAGPVLGMLLKLKGYDPIIYERLDAPSDMGLSLALQANGLKVLNLIPGLVDKIPMHELAELVQYSALPDDERELARMRPPQKEVAGYSMNGVRRPVMLRVLIEEAEARGVPVVFGHQLVGFEQHAESVTARFANGATDTGSFLVGCDGLHSDTRKTLFGEEAVSFTGLTQTGGISPYPETFRAKGEAPPGFNIYGDGMHMVGYPVNDNEISWAITRREGEAKETWRAMDEERQKEFREGPYSRLPFWGGELVRTAARIIKYGLYDRPELPTWHKGRVVLIGDAAHPTSPHLGQGANQAMEDCYHLTRLLLAHNPSGAPPSTALLETIFTEFEGPRIARTSELVKGARQQGELRVVDGAEACKKRNEVIAEMYSGSDGGLVAQFVHLVENPFKAGESEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJJ0</accession>
    <name>A0A2G8SJJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJJ0"/>
    <dbReference type="OrthoDB" id="3215534at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="986" mass="106709" checksum="BA74D6378365812C" modified="2018-01-31" version="1">MLHPSSAQSSAALLRQPVGFGAHAVPPPTYHPSLAHSPPHHYPAEPHASKKKSSKGKEKEKSKEKSNHASRKGKERDKGTPIQPAPAPSPYPVSQPHPGAPQQRTAFRVRAYTNDPSATGTPPSIQEGPYGAAYRVGAGEDGRSRSHANRQHAQTAPGATDTQPRPSYYRYDYDKIRDSAPANRAKQQAAGIPIPSTSPYAPPPPSHRVAPPQQLYPHHSSSPVPTSSSRPHGSSSSSRSSKRKDTHMYPTDNIYPSPQPSYSDTYDWSQDTYFSPAPAPDPNHYAPTPVPVYEASPPPAPAPPPRKEKRHKSRSHRHHEPPPQQYPPLDSGYAPAPVQTQPPIPQPPTRVVRILTLLIEDKRQYHDEENENLLTEVRVPLRPADPGDTGMWADAQEVSEELQKGPSRIDGRAKVYTLRGKYKQYFLRTSEDGTHVCQPANLKVTPERTLEIFIEDNPLPAGQYYAHHSLRTPSSPPRDLPTPSTDRRSMTIPSPSPAPASVSSSLQLQIGIPGPTPPAEKRPSHSSLFSGDDDFQAPSPEEFKYDAPSSSKKRPRSSSAQSVQSVRSATPQHQPLDDAFSPFEHREPSEMPVSAVQSRTSSVASQPSQPRAPQPFPAPPPLYDPAPVSPVSPFEFSDTTTPQAAQTRVPSAQHSRSPSTSSFSQTAPSPAPSRAPSGSKPSPTKKAKLDRLGVPQVQPPHESQAHTEYSVSPASTSRPPAFPFSDTRTTPRVVSGFEAYANKPPPVAFSGPPPAPAPAAPNPFARYRGDDAASSLPSFSFSASQSQPKPSPITIPTVPMKPTFSPPSSPLLANTSPQPSMPTTMAPTALTITPTLSGEASSELDNAVGKYIRGIIVDEPAWKTFVANRSRVLPMRAQLTQYRYVAGVVARFAGSTTPVDLPGAAGVCVSQGQVVKAFNLKREWWEECEEILGLAGMYGEGGSRGQDPRVVGMLDEEPPITTGMQAKKFLKVLREVHAQWTMKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJV3</accession>
    <name>A0A2G8SJV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJV3"/>
    <dbReference type="OrthoDB" id="2804054at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="519" mass="54095" checksum="2E8070CE550F3A19" modified="2018-01-31" version="1">MESFDNMTPIVGSRRPIFLPAFSDHSSSSSSHTHTPTPPSALSSATSLVSSSRSRRKPAYAFKSPSAEEPSQPQPGEWEAHHPTRTSPTAINIGKRASPPYERRRGSASTDASRSSAHKYTPSVKSAVQRHAPLLPLYHPLGPLAQSLPRLDPGLFGLPSSLSIDDGEDKPDAEGDPRSSSGSRRAGPKGREDDTQSNGTPNGVDKAAQDATARERNASPRKRRGGGGGKRKRKDADDADGMFPPPAKRTRNPRGAAANSSVPAAPSPLVGPAVVASDLALEEIPENNGVASADAEEPEEAQEEPEIQQTPKRTRTRKPRATRPAKRRDSSGSASAASSVSVSIAAATRAAAAAAPSVGLSTEDGQMGEPEPEPEPTPQPEPRPELRASEPPPQAPQPMVNGVGAHEEADSGRPSGIPSSTRAPIEKPAASGQKEKLQQSSTAGDAPPAAGPSRNASKDVPLNGVTHTPSSRVTATVPTAAAAKPLPKPPTAVAPTQKQPPPPRVPPQKEEREEGELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJV5</accession>
    <name>A0A2G8SJV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJV5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJV5"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="165"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="792"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="326"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1020" mass="110634" checksum="985B509591C7340F" modified="2018-01-31" version="1">MAGYIHADCLPTQALKHHTSKLASFSDLDTVTTFGFRGEALSSLCALSDAVSVTTATAADAPAGTVIDFDRAGKAKPKKAKAARQRGTTVSVSGLFKPLPVRRKELERNARREHAKALALLHAYALVPCAHENHGVRLVVTNHTPQGKKTVQIRTDGTPSTRASVAAIWGPKALGHLVDLDLAFAVEVDAAVLRRLGRTPDDGDAHANEVRVKGLISRFAVGCGRNGTDRQFFFVNGRPCTPTKVQKAFNEVYRSFNATQAPFLVADFILPTNSCDVNVSPDKRTILLHSENNLIQALKAALEETYAPSRATFDVNPSQAPRKAEIAPLLSQRASARSKDKAATVHDKEKVPLFLPGEDAEGAHQSSQSDGDEEVGEEADQSAFGELALLLEPSQPGPSRTFGGDEDEQGDADSLARIEDETRGSQTVTQMMKRGRGVQDVADRDKSSDAEDDDAGEDVLPRSQQPLAKLVEARRKTTLVVAEASQEDDQGEENAPIPSLRPPVRPVARAPESVRAKAGGSGPSRGGGGGSGGGEQMVLSTSGASWSLRRKAEAEASDGPERARKRRRVEGKEAQAGMRVLLSQFARKGSRVEEVEEVEEFEEDEEDRTHAEEEDGEERRDEESTTDEGEDGMRELVEEEMGDVEMGEAVETELNDGVAPNEDDLGEEERPIAIDVDDDEDDAIHVLSPAKAAKRAPGGSNVGTSAVSATSEEVVRTSDCAAIPISIDLSSLTASWKKLRERLSDARQREVRERDAKAKLDSTAGVGNTDDEEAVEALSRVIDKPDFATMEVIGQFNLGFIIVRRRKSRAGGDGGVSASDEEESVMDDLFIVDQHAADEKYNFETLQRTTKIESQQMISPEVLELAAADELVALENMDMLHQNGFELDIADDRPAGQRVRMTAHPVSGTTKFTAKDLEELLHLMHDRPAGQMVRCSKARAMFAMRACRRSIMIGTALNKRQMALVVQHMGTMDQPWHCPHGRPTMRHLSDIVGMGWNCRGGSVKAVDWAAFAYTARTVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKY5</accession>
    <name>A0A2G8SKY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKY5"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="305"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="442" mass="48317" checksum="877A61A63CF8C151" modified="2018-01-31" version="1">MSLESNQPSLRVAIIGGGMGGLVLAMCLKKYAPDVDFDIYESAAELTEIGAGIGMTPRIWWIMKELGLEDELLTIAGSKDRDGFPLQHRKGDEEQGVHIAYTERIYTFHRSIMQQLLAKHLDAGDKIHFSKRLKSYSETSATEPITLTFKDGTTATCDLVVGSDGIRSAVRRTMFNELADDAEKHGDGEKATRLRDMIEPVYTGQIAYRGVVPTSALSDEIVQYAKAPLLDMMFYPVSGGKLVNALAVKYTPGHGRTYDGPWVKPTTAGDVVKLFEGWETNALTLFKAVTEPLCWAIHTVPDLPTYVKGRVALIGDAAHAQLPHQGAGVGQASEDGYILATILAHPSVTLNNLPAALAVYDDVQRPFSQSVLHGSDRNGMNFQLRRAGWENVSAEDSKAGRYAPELLAAVGEEVIKQVKWAYETNIEDDRARVVERVAALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLG3</accession>
    <name>A0A2G8SLG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLG3"/>
    <dbReference type="OrthoDB" id="376357at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="7"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="360" mass="40014" checksum="10995D86096E7BAE" modified="2018-01-31" version="1">MSTEDVNPYELLGLSIEATEQEIKTAYRQRSLKVHPDRNRGNPDAARKFHELHQAQELLLDPLRRMALDAKLRIKEARKARYATYDAKRKGLVEELEERERALKKARLETENEKKQRLRENERIMEEGRQLREQRERELQRKERERDALQQKVQQEANAGVEPPPSGPLDTTVRVKYALASRPTLVDAASISAVLTPFGAIDESSVVLSLKPAPPKKPKRGTALVPFTQIGGAFAAVCASERAEHGLQDIEVSWAGGAEPELIGWLKKMGQLGGTANGKPPPPSADHKSPAPTAAAPASDDAFSSFPSTFPDLDGAPRRPSAPTAVAGLDYESLTLMRMRQAERERLEREIREQEAAEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM92</accession>
    <name>A0A2G8SM92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02646</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM92"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM92"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="32276" checksum="EB7EA68EE4C90F5C" modified="2018-01-31" version="1">MSYNISTQPRIAIIGAGLGGLALLLTLHHRDRTTTSATSALTPAPTPAATSTSDGRGASARCARMASNFAFDKHSRPEGEEMRICDSIGKVHLKLGGEGQDRPLQGKEDIRPEIDRTVPRKLLLDAVPAHLVQWDHALSSVRSLGDGQHELTSTNGITATCDLLVGADGAHSRVRPLLSPATPQFLGVNGAEISLASSTTKLPALAETIANVGQGTMMAMEDSRMLGAQVNGDGRIRTYAFLHAPASWTLPADPPSAKAALKEEFAGWAEWLLNLIDYYDDGAIYLHALWSLPVGHQWAHVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMD6</accession>
    <name>A0A2G8SMD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMD6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMD6"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="286" mass="31025" checksum="3E60DABA462733BC" modified="2018-01-31" version="1">MSDFTPRVWFITGTSTGLGRAVAELALEKGDIVVGTARRPSTLDDLAQRYPKDRLLVLPLDVTHPEQVVDAFAAAVRTLGRIDVVFNNAGKADVGEFEGIEEAKARDLLETNFWGAVSVTKEAVKCFRETNPPGAGGRLLQVSSLGGLVGMPACSFYCAAKFALEGASETLAAELDPAWNIKITIIEPGWIRTEVAPRASWSPEHPAYNQNPALPTTYIRRAGWDKVTVWKDARRSAEVFYKVACLPDPPLRVLVGKDAISATRKKIAALTANIDAYEALSEGLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN38</accession>
    <name>A0A2G8SN38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN38"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN38"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="13">
        <location>
            <begin position="187"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="226"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL35170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="292" mass="31246" checksum="5AA73103CE406A1F" modified="2018-01-31" version="1">MNVYLDMVDLGRYSDRVHLILSLIHVLLSRTSALAKMFRTLARASSRSLHTLSRPASSARSNARLRAVLGVSAVATSYLVWNSWYGQRIALDSSRSPPKAPSTPEPTPSPEFVPDEPPSPPKDEPSIPPASRPPSDAQPEGEAKGDQPAEGAEGEGEGSAQGGAFNPETGEINWDCPCLGGMAHGPCGLQFREAFSCFVFSEADPKGIDCVEKFKAMQECFREHPDVYGDDIMNDDDEEEEGLALDSASPRVPDAVEPANSPAAAPSERSEAAPPPAEQKSKPRKPAPSTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNA8</accession>
    <name>A0A2G8SNA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNA8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="159" mass="17545" checksum="1AC9C4F53ADF08B7" modified="2018-01-31" version="1">MAVACPARTVPSTEHKLLARTDPVPPYVPFLAYQRPPITIPSPPGCPFPAKPSVRLTHSRPLSVICHPSPPPLVFRRVPCLRSRKRSPLGHPCAQAWQTSGTQSKFPKPFPYQRPCISKSPSQARLRIRRVALRAAALAYLGRPTADETIRKLGYGKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP43</accession>
    <name>A0A2G8SP43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP43"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10695" checksum="5D29A40B6FA9E03C" modified="2018-01-31" version="1">MATTPETQWHTVTIRIPFASDKDADIAKQVIDVDREMQPDVVKRTLSVEGSELVATFTTLTVRLARLTTNAFLENVDLVVRTIGEFGEDAARVPAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPG4</accession>
    <name>A0A2G8SPG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPG4"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="131"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="271" mass="30773" checksum="D87CBF56D8B5B410" modified="2018-01-31" version="1">MPATPFRKPRQSLEAFDKLFERAFAPRDTPPLSLAPLALTDDRDVRPPSPKTQFYSPMETEFPISDGHDHSLDSLWDEVRQAKEVELESSPSKVKSLEGATLSLGSSQSGTAPVRRQTTGEQPQSPGRKRVTKRRSSVNFRESADGRNIMVTFDMTGVKKQDMHVSYRSSRLIVNWKVERTTEKQEEDGVVREREVRRYSHTIPLPEGTKFEEVRASRDSQRLTLTLPSWKCVRMDGDGPEDQLPESLRLIPDIDVCVLRCADFASRLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPQ3</accession>
    <name>A0A2G8SPQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">GSI_02475</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPQ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPQ3"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="183"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="374" mass="40616" checksum="6E736811900826EC" modified="2018-01-31" version="1">MASDNSAKRVVYLEDIEVKPSKGSATKENASVAVTEETTDGSTVVDTDASTTVTEKKTTTGATKRQKAITDMFTKKSSSSSSSSSRSGPLPKKARSDTPSLNSIPFSLKEYQDSLSEEEKTLLTLECETLGKSWLKLLKDEIKKPYFLTLKRFLAGEGVKGLNDSAPNLKVYPAPKNIYSWSNMTPLGRVKVVIIGQDPYHGPGQAHGLCFSVPQGVAIPPSLRNIYAEIKAEYPSFEPSKHGNLTTWAENGVLLLNTSLTVRAHEAASHSKRGWEEFTAKVVDVVDRYGGANLGDKSSSDAGRGRGIVFLVWGAHAAKVVAKLDKKKHLILTSAHPSPLSANRGFMGNGHFKKANDWLEEKYGPDGCVDWTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPU0</accession>
    <name>A0A2G8SPU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPU0"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="31"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="515" mass="55838" checksum="89FA11095F14107C" modified="2018-01-31" version="1">MTGHHLEDDEETPLLRSESRKHQRTPIPWGQFTILLICQLAEPLTSQVINPFAPELIRSIGITHGDETKVGYYVGVMQSIFYATQALTVMHWSRISDHLGRKPVFMTGLMGLSLSMYCFGLSRTFWGAVISRSLNGALNGNIGVMKSMLAEITDSTNIAQAYAFMPIAWSTGATIGPAIGGSLSHPAERHPDIFGQNEFLKKYPYFLACSIPATFSMLACFITLFFLKETVRNPVSLRKLLRLSPKEAAVESEASTVVNAPLADDKSGPVPFKKLLVPRVIIPAANYAFLAIVDITLRAIQPVFYATPIALGGLGLNPQEIGWILSVYGVINGVVQLSLFSRANERFGSKRVYLAGIAIVLPVFALFPVINEIARVEGMIPMVWGLVMGQALLSIIINFSYGAVFIFITASAPNKASLGSVNGMAQLLVSIMRAVGPATANSLFSLSIDDVHHYMGGYFVYYALSAIVLVAFWVGTLLPDDPSYALEDNVKSLSSSSTSDSGPSSSSSSTFSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPZ6</accession>
    <name>A0A2G8SPZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01505</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPZ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPZ6"/>
    <dbReference type="OrthoDB" id="2803502at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24207:SF2">
        <property type="entry name" value="ZYX102 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL35845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="182" mass="20786" checksum="5C6A8261A03749F6" modified="2018-01-31" version="1">MDESTTEETKKTQTRLTEDRICRKCERSVVDAKEGVVITFGQSVFHISCFKCAKCGNQATAGADLLLLSDGAPICADCSYRCGMCMLPILDEAILTGEESYHTHCFKCRKCERQIEELVFAKTSRGMYCMGCHNERVERGRERRAKKEDEERERDLEYARVLQKQQQQQGAETTALDVRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQD1</accession>
    <name>A0A2G8SQD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQD1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQD1"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="535" mass="57931" checksum="C71E913E4678C8AC" modified="2018-01-31" version="1">MTLGPPPSAAGPSSNAAGATAPTSSSQAAYPTSVGPSSSNTATPSPNPSIPANAYMSQFVVQPQPASRPYYPMSHLSAHPVNAQAGASQPPSQPYPAQGTYYPQQGPATGSSQPPPGSYSYYGYPSNAWANAWNSTTYQFPSGGSYSYSYPPLPQAGSQTAAFAPPPVPAASAKQKSPSPSPSPPPEYHKDWDAVIKSFLSSLGLSQALRGFEADMVVLNPDCERKNVPQALGILMTNLLQLGQAKNEDDEDTVMQERPLEERKLDHVHLANGVEPRSNTSITKDISRFLAQNRARNDASNRNEFLLSIAEKRRRLNENGEFEASSPLPSCARTDAKTQNRDLQMKYDIVKNEDGPLRRTMKPGALSGTNSSQHTAPAKDNHNGAARPTEGYPSVERYPALDERLQNVEKHFAVRYVPSPPRSLLDRLKYLEDHIIHLEKEYPPWAALHFNQPNRGWPPPPRATPIIVPSHLTSANRQPQQPLADSHTPTAGISEACAGDTKVKLARRTKSSLHRAVMEKLEVQKAMNDLAGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQG3</accession>
    <name>A0A2G8SQG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar sorting protein Vps3844 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQG3"/>
    <dbReference type="OrthoDB" id="5583277at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053065">
        <property type="entry name" value="Archenteron_Induction-Rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024382">
        <property type="entry name" value="Vps3844_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853:SF1">
        <property type="entry name" value="DUF3844 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36853">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12955">
        <property type="entry name" value="Vps3844_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013809121" description="Vacuolar sorting protein Vps3844 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar sorting protein Vps3844 C-terminal" evidence="3">
        <location>
            <begin position="250"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="354" mass="37687" checksum="632E35B6C03A7F8E" modified="2018-01-31" version="1">MKGLFIPLLLTSLCQAVRVYLHPGPHVPPRLHANTAGAALSKHLDLDRFEDAAPYFGEQELFVGHGSDTGLLLTISQDDARAVIPHSLKESTFSISPAPTSASLSALIPNYISRAHHVYSYVYEPAASFTHTSAAAALQAFVDLKDFIEGDYPADRFAAFDFTSLTASLEGHFGADHEQVHEAHKTLRETLKTLAARNNVKLAVVSIPSLKPHVHHNKHGHGHGHHKRQPQQSPLPLPHPAEPIDSISTCYSDAETCGNATSSCSGHGQCVAASKAGKTCFVCACSTTKDLKGRREHWAGNACERQDVSGPFVLLAGTTLTLFLLVGGSVALLSAVGGEKLPSTLTGGVAPHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQV2</accession>
    <name>A0A2G8SQV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_01807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQV2"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="33"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="127"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="228"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="358" mass="38868" checksum="C626DABA42158CAD" modified="2018-01-31" version="1">MKVLAILYKGGEAAQQEPRLLGTIENQLGLREWLESEGHEFIVSDDKEGPDSVFQKNIVDAEVLITTPFHPGYLTRDLVSKAKNLKICITAGVGSDHVDLNAAVDAGIEVLEVSGSNVVSVAEHVVMSILLLVRNFVPAHEMIERGDWQVSDIARNAFDLEGKVVGTIGAGRIGYRVLQRLRPFDCKELIYYDYAPLPDAAAKAVGARRVADLKEFVAQCDVVTVNCPLHEGTRGLVNAELLKSFKKGAWLVNTARGAICDKDAVAAALKSGQLSGYSGDVWDVQPAPKDHVWRTAKNPLGGGNGMVPHYSGTTLDAQARYAAGTRSILENYLKGTDQEPQNVIIGRKGYETKAYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQV5</accession>
    <name>A0A2G8SQV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQV5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQV5"/>
    <dbReference type="OrthoDB" id="10673014at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013815957" description="Transporter" evidence="2">
        <location>
            <begin position="20"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="52827" checksum="7B73C08C9767FE1B" modified="2018-01-31" version="1">MRFLLHFTQLTILAVSLDAAPVASSFRRLERRQSDGNVSQLIPPAITTTTSDVPSRLAQDFEALRDRRTCLGDPTQINALVQNIVTDLIALLSMVVPSSCDASSQTASTIPPDPSDAGPSNDQSDPFQAQLGDFGPDDSFGGVRSGFDDGCTADELGLLGDNGGGTNSGDLGSLNFGDTGDFAFVKPPLANDDATSPSGASTSGSGGPSSNASSTNDASSDGTNLDSPSGCSGSTCASSNVPSVGGFPTIRVGGDQAPDVNAGSGANSGFIGGSGDTTTASGTENLGNNVATDNASDSLGFNSPSFSTGSPPLGGSPPFSDGDSSAIGGSSSPSAALSTGSGDSSSADTGSTVEPNASESTLSSGSRGSADGTSGTQGTSGAPIGTSGVFSPGSGPTGDGQPGNISGGNAVSQTGLDDLSSGTGDSRNAVAAGGTGPSSGGSLPGSSVSPSTSNGDSPSASGGSSTPDDDGKFAVGVQRNGTGGNSNSDGAPGSPVSSPNSSPSSTTTACPSSTGYPNLHVHVSNPAVAACVNIGYITNRTTGNLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSC0</accession>
    <name>A0A2G8SSC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSC0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSC0"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12363">
        <property type="entry name" value="RRM_TRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="291" mass="33436" checksum="62D4D17AECC1B957" modified="2018-01-31" version="1">MVSLAPTPPATSPSLYSDSAPAADPYNEAYNTDPPPPAAAPASDSRDRDLPPARGRSRSRSPQRSSSYRRSPPPRRPPQAPVAPNPSNVLGVFGLSIRTTERDLDDEFSRFGRVEKVVIVYDQRSDRSRGFGFITMSNVDEAGRCIKELNGVELNGRRIRVDYSVTDRPHAPTPGEYMGHRRRRGRDTYSGRDVERSDRYDRYEDRERRDRDPYRSRYDRDDRDRDHYGRDSRDWRDRRSPPPRSRYSPEYRRRRSYSRSPPRGSSPTRARDYDAPSSSALPANGNGDSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STH8</accession>
    <name>A0A2G8STH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STH8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="75" mass="8242" checksum="B60C2EF96CD0DB5B" modified="2018-01-31" version="1">MRKTAAQSFMPTNAAACRDRKVNPTRGVDDARFELVDKFTESSVQKTPMQGGLPPSAGEPVREMHVSVAHQQLKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU39</accession>
    <name>A0A2G8SU39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LCL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU39"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU39"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013849645" description="Long chronological lifespan protein 2" evidence="4">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="114" mass="12584" checksum="3D9DD2DAAF6DE116" modified="2018-01-31" version="1">MLLHAFLLCFTLQFSLVFAQFGFFEQMFGGHPQQQQRPAGGMGQWQAHSEAVECSNYLCPDTLVCVSQPSDCPCPDVQDVKCLIPDAQDQGASTVVCVRGQDECADVLRLSRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUE1</accession>
    <name>A0A2G8SUE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUE1"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="453"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL37380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="59861" checksum="4ED8C31368992A71" modified="2018-01-31" version="1">MDNSRPSSPDAPPQDLWSSILDSVSSSRSIPSKQIILLGEPSSGKSSLVSALLQKPPPDESKEETRTDFAIGYDWADVRDDADEDTLARLSVYTVPSSAPSYSALLPHFVPPRASLPHTLVMIALDWTRPWLFVQELVTWLEWVEKWVKGDGSRELDIAKEENRERLQVHWQHYTEPSAEPLPAAATVNGTVLPLGQGTLTHNSAGVPIVVVCTKADLIDEGSDIIGSGPSGMGGMVKGKGGEWEERTDSIMQVLRTVCLKYGAGLFYTTPQPTTLQVLRQYALHTLFMPPAPSPAMAGSEVTAPPRNPFPFPHKPNALDRDKIVVPAGWDSWGKIGVLREGFDPKLWGEGWENDLDGGDDSDGSKATRLYANLVPDLSRKPPPLPPLNNPTPEQVFLAKNYDENAKNPNRDPRGAFRNPNETASAGIVGPMGSSSFNLPNVERALTEMEGSAAPTANPLNMSVAGEPARKLASRTAARPAPSTLSVPSAGAALLGRSTSGASPGPLSATTPNSADDQTQHQALKKFFDDLINKRNRVDDKGATPKSPDGDGGADEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV71</accession>
    <name>A0A2G8SV71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01355</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV71"/>
    <dbReference type="OrthoDB" id="3232438at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="628" mass="70292" checksum="94E1B1765BD0C07F" modified="2018-01-31" version="1">MSGRSEQGVRVQQGRALLQRQEMHVRSVTAARASRLATSNPNPWSPSLGVDIDTEGFSIVLQLAVLAVSMVYCCRSAFVTPGGRRGAAWCCAGVYLIQHVSGEDAHGFSRATLYVHGKILLAYLPTSKLEHITNKAARCRTLANLFHACLRRALAPLASAGVDGIKLVRGDGVKHRGHPILAVYVGDYPEQLLVTGCKNSECPKCSVPHADLGAETDTSRALRDLGKVLDALATLDDGPRAYTRACHEAGIKPIFHPYWEDLPFANIFLAITPDLLHQLYQGVVKHLIAWLKEAYGMTELDARCRQLPQNYSLRHFSNGISKLSRVTGKEHQDICRILLGLITGLSPQNGVSPARIECSTRALLDFLYYAAYPTHTAGTLKLLDDALWRFHANKAVFVDLGIREHFKLPKLHFLDHYRECIEMFGSTDNYDTQHSERLHIDFAKDAFRTTNGKDELSQMTIWMERKEKIEHHEEYINWHLQQDEAARAMLEALSVTFEELAEHYGASFFRDALKRFVVEHNSAVTLMHAQVERASAAIYFPFSKVLVWHRVKFWISDPYDVTKHIDPIKDTAHIRPARKGKYGVHVPGRFDTVLVNDSSGGVVGIKGYRVAQLFSPAQLAHSPLFSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLK8</accession>
    <name>A0A2G8RLK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLK8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLK8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="110" mass="12100" checksum="16582058AF6353C7" modified="2018-01-31" version="1">MDSGVWSIRVCSVSRGITVFIVQMFYCRRISVLAPTYYKYLAVGMVPLILSELGFSIAAAVEAFIVGTFTGWERKAWIDGAALAIVMVADIIVAATMVIILYKSRTGIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLR0</accession>
    <name>A0A2G8RLR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLR0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLR0"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="210"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="302" mass="33424" checksum="FD1B94FAE4B991F7" modified="2018-01-31" version="1">MVFISADYRLLPPATGHDILADIKDLFAFIDRDVNVLVRGCKGTRAFEIDSSALAVAGSSAGALCAYLASMHASPRPKAVLSLYGMGGDMLTWQYLTTKTTPFFRGREMLDPVEFSDFLYPQCQHLLPTSDSPLAYHPPTYHIPGYPANPRQLLGRLYLQLGTFLDYYTGAHEPSLSGSLQEILAKSGRLSQRSDIEDTNADYAAHVPAEHRPLFPQFNVNAQFPSTLLIHGSADTAVFIRESQAIHAQLKSSGVRSELKIVEGKEHNFDYDTKAEEEFGQPGGLFEQAIDFLKEHLTKREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMG3</accession>
    <name>A0A2G8RMG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15398</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMG3"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="47"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="171"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="405" mass="44636" checksum="C1F3E3AFCAD384FC" modified="2018-01-31" version="1">MTMSSAAVLPQDALPQPLQFKGEIMDFDLAGLEVDHRKRRRNRTTQSCLNCHTSKRKCDRKRPCQRCIQLGLTGLCVYEVDDPALRDDPNIDENTRLRNRIAELESLVRELRGKPHPKWAEPNFCDGDANEKWHSRSSRRLQYQKLPRDRHDDGQHLQGANGRGPPAIKTEQANDPSQQNLYRFTPSPTHPTVDGSSGHSYGLYRQQAHGHGQGVYSPADDSSCYSSPSSASVMTYSEARHGAHGVTNGEHYYQQEQAHQQYVHAQTPPCPCLTNPAAGNALIGLTTQLQNTAVLLRQLPEHNTARQTCAIVRRVTELTDIMHGNTVAGGSSYEGLSTPTETELSMSPISTSSQSSMGASAPGMHEQWPGAASMAQSAAGYDSYFPVAATQPEHAAVFHKTYHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN76</accession>
    <name>A0A2G8RN76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN76"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN76"/>
    <dbReference type="OrthoDB" id="43122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38700">
        <property type="entry name" value="YALI0E22418P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="417"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="593" mass="64907" checksum="7BBCB534DFFD08B6" modified="2018-01-31" version="1">MPPTSSPPKDDTTDDDVPLAQQIPGALKAQRTIRRQVRDELDQKRAERRARAQQALLQQQQQQQHEEQRPTIPSQQSSPSRPAGRPRTRTLPSTMNSPFSAGDLTNKLLSLQTSPPGATPPSVPPMPSSASPLPGRSKRPSFDGNEQHTSSLARGRTITGDLGSFAPSAQRSQPAQEGARTLRPTRSFHRRPRTADPETTPPLPAQTPPSAPLSRSGTSLSRSGTTSRRRPAVEEPLPPPPYSANAPALDRGKSTRSAPSRRPSYERQDRQENSGFVVTSRSRAATAQAQAQVAAAPPPLSPSVFAQPAKGSGAQMWQQRVFIGNMQRFVLVEIGSVTTAGDVLSIVDGQGALEQGRDGWMLWEVSQDFGMERPIRTFEMLNDVCGAWNSDKTVNLLVIKKTLLAPLLSPRAMPSSSPMCSGYVQWEYKRGKWQKRWMELREHSLWLSKRDTGKDAQFLCSLNNFDAYYVTRVHKAPKPYVFSVKSTDSLTYFEDTSDYVHVFSCGESEGKNWLEKILLARSYVLYQERNVVSASSAAATGSAAPSSSGAGALQRSGTRRRPAQPLLTVGPPKNDMVAPLNFEAPAGSLLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNR8</accession>
    <name>A0A2G8RNR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RNR8"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1903" mass="213148" checksum="A6B369FA5750FB5F" modified="2018-01-31" version="1">MSRNVDVRVVARRPSVRQVLANPLHCAVRTISTIENVELFVDEISVAVRSGTGIENLTIRLTGLPIFQDTLVLPIRASLQLVPELTDLTLLLPLAPPPDFLLNINFRALQFFKSNLPHSALTNFLARHQSVSDLVLGPCGPAIRCPLHEVDLTHVTDLECEAECVRSLVHSDLFRLTIGKSTDGPRVGVIFRTSPVSVPGLYSLTIDFFPDDVDVLDNLAVFAPFLRKLKLLEQRGSSRRDRSGRRPFNDALTWARALRKLRFLEELSLQTSAGLILRPGDYHLEHSLVLGWVYGVRTRALRRPPPSAKAHPTLYHVRLWYGARGEDPALSKWYKDGKEWRRLGRPILWALRRNPPAHLPTQSQPPRDLTPFDADNSMASTLVAPSDVEKSPTTAASLLTGSNSATDTSSETSSPRSSPPSSVNGDDSTVELAVKALMSSAEVTHTVSSLLMRSHELVSRVSGNQSAAGEDTTTGPEGTTQESEDMLAFATLITRTLEAVKQLAQLQEESSERLFNLESTVVNVRGDMERVQSRANRLLYRTRELVRKERETAWGEERLAVTGQGALIQDVYRLNMDLMSLNERNTMILDGLRGLEAALEELKANGARSSTGPAFRRLWDVLQDYGWGVLEFLGCGAGRVFGWMLSAFETMISACLAWPLPSSPFAPLPLYPFAPLPSLAVQYSPFRSSSHDAKQKYGSRSFGTDVLLATMSNRLAVRAQDSVAVRLRDVRADGSASTNDAALDSHVELEGQESPPTGQDSVAASNPDTVQATVEPISHLREASIPPVVQDAPALRVDVEDPFALEPEVVVDDSISPQERLREVGDMQSILHRAEARFRRPILKFTNVPQSLHDPPSDLDASDPFTAEFVEYRTETLPNLHTRASQLLPVGDRSVDQLHARLVEDIKTYTERAIRSQLDAWRDEVMKLPHANLDTLEDGPPIVTTDDVFVARNVMQPFVTVALIIAVVLHGMAAVARPEVAFVLSGLRAMLFGAFAWCNAPSRSMSAAQRLLLKCIPRDVRTVLRTLHLEPDIVRYACCPRCCALYPPSDDPTKCDDPYPHTCTYSTTDGDLCGTKLVFEETQAPRQKNGPKRAVFKPFRVFPYRTLRSWLKVFLSRPEVEAALAASWQQTDASGAWHDIMDSPAIRQFRGPDNTTLFSVQQHGSLNLVFSLFVDWFNPYGNKKAGKSHSIGAIYLACLNLPIDLRYAPEYIYLAGIIPGPREPALDELNHFLRPLIDEFLVLWTRGLYFGRTALRWTGRFVRAALIPLVCDLPALRKTAGFAGHSSKHLCSFCPLPKDDIGNLNRSTWPARRTRAEHLRIATEWRDATKARRDEIFDEHGLRWSELLRLPYWDPTRFAVLDSMHNLFLGELRHHCMNVWGIDIRDKSPGSKKLLPHTPEEQTRFLQNAVDALKKHSATALSKLRKGYVVSIAKLNDVTPPGAALTKSAYVNALIDWVQTVDADAIRIPPVLDHDATDFHLADDMGADISKYRVLSYDVLQSIRADLRSTYLPSWLERPPSNFGSPSHGKLKADQWRTICTVNMVISLVRLWDSPEASPHDKLLLENFLHLVAAVDIASRRSMSRDRALAYDKHMFDYLCGLQRIFDHDFVPNHHLSLHLYECLVLFGPVHGWWAFPFERYNGLMHRININHKPAEMPLTFMRYFYIGANLRQLMAGLDLPNDPEYTDMMTSFGRAFSVASRGTDALNPLASLSGSRRDRRGGISKVREMELPKNVYDAILHLVNQSSEEVFASDYTTSFGHADCLVLSPTAQEVNRIEHHRVSFSTRSRGIRDSFVIFKGLDGDSHAGQISRIFLHTRTRLGELVVEPFILVDVYEPLSGDNEGHDPYRKWADIRTHLCYNTFQGDSQVIRLQDIVSHFAAFSYTPDALDRECIVVRDLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNZ3</accession>
    <name>A0A2G8RNZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14539</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNZ3"/>
    <dbReference type="OrthoDB" id="3185525at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="733"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="577"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137000" checksum="5A1F719A4F01137C" modified="2018-01-31" version="1">MLSLSPYIRPPLKTVYYRLDSPSLHKFLHVAHELQDAAWAFRKWHARRHGRTGGPEHVQEGWSTFDEDDMYVLGGRNDPKAYVFKFLESPPYPSLEGPGNIYHEIWLYQQVCKDYKWTGAERTIDWVRDARKNTPSASLRDYEACVASPSANVSTVLRDPLWRANTLLLCAMRYPPIDPDAVDYDSDTGSEFMETTFPMFPYRFPSVSMPARVRTVAFDLFGTILDRDGAIHDALTPWTLVSGCRKTAAQLTKLYLEREALINYHCSATPRSLARIVHSALTEVSERLDLRISPHSAMFHDAMTRILAPGLFPDVEPAVTALAYRGVRLVCFPPHTLTTMAHYKSRLPRAFLDHVSFTPIAAPVHTEAPREMFRSIGHEHTPQLRMPARPELRSDRDSEVLVVSTGVGRILAPAIKGKLATALLKRPESVEANVDFCIGLRPGDNPEPLLVVHGLMELCAALKLLENIATPVLPRTFKEHHSGLPRRLQGVPCTARTAAGPANAATGETIDTAAHSLLTTTINTPRRREQNMDFAGSATHQRSPHESSQAKLNVPDPKDTNVGHMLEFTDEEKANVWKNAARAVQTYHDELIEQWQKAMDTLLVYAGLFSAVLTAFNVQSYPLLQPAPTDATLAVLQQISAQLNSFTVNPSFINSTQPASSLAQLQAPFRAPLSAIWVNALWFSSLVFSLASASIALIVKQWLHEVSSGLSGTSRETARLRQHRLNSLVKWKVGTIVLVPSVFLQIALVLFLSGLLILLWTIHEAVAIVATVLVGALFLFFTVVTALPVFQWDCCYRSPQARGVFFLMRSVWNGTILFMLRTVATLCLAITDGRMYERSLLLRRLANALFAFCVGAVNVLPRMPTWYGAEQTEVARDTGLLDRQIAMTAYTITFATHHLKTLPIVLSDLPCEQIAWCFHDVYHAWCKLWGLMDIEVSSRRLKETLFSRSLFYALRKMLSVDYETRQRIGDDWLHVPGRFLWGAEDILPRSDECLSTLVQLSIGDSALAKRAWTLLDRCFLDENSPAIDFSITSETLRNIFSMCRWHAERWDVHHPESPPLQLSASRLLLVGIRQILIDNSGLSLGNEALILDEAQDYLSFLKTKISTIDWERWRPKNPWDLAWLLRDDLLGPLLVLCRDVPGACEVVPNGLLVGIRRSLAFLDPLCTEGPDSEIESEAVGAVDHNIMMEALKSEIRRWRHREAQAVPCFFVQQPPVVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPA0</accession>
    <name>A0A2G8RPA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPA0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPA0"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="329" mass="36940" checksum="A554CE39DAA95E20" modified="2018-01-31" version="1">MRSLPSLRSSVHASFKPPSRYLWLRARYVSTTPQRQSGQLSTSPSDTPVSQSKGKEKETAPVADAAAAVAHDELPLLQRPLGVKEKPKARVKTWSDTKEKFMDQDKRMEERTHLAREAMRGHFSDLNATRKHGGKTWIAPKVMIREDRALYFPDIHGTSLAGREEQVHTTNILEGKVSVVTLLTTRISEIQAAQFVEPTQRAFGSNPHFQFVQINLQDNLVKSWLVSLFQSGIRKQVPEKLWPTYMISNQNMEYLREPLGIGNKHVGYVYLVDTNKKIRWAACADPKSEEVAALATCTKVLLDRLAKQQELIAPAADSSSSIPAVEQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPC1</accession>
    <name>A0A2G8RPC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_14685</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPC1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPC1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="37"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="519" mass="58329" checksum="284337FDB8D45719" modified="2018-01-31" version="1">MAPGVAATAGSAEGFMHLVDPNRKWYNNKRLITLHAWLVLLLITSSTNGFDGSLMNSLQSMTQWETFFHKPEGPTLGLLNAIQNIGSLAGYPFAPYLSDGIGRRPSIWIGAVCMLAGAALQTACQNIHQFIGARFLIGFGLSLASNAAPMLVTEVSYPVYRPQLSSLYNTLWYSGNIIASWSAFGTSRINSNWSWRIPSLLQAIPSFFQFFLIWFVPESPRWLVSKGKETQALHTLAYYHADGDESDPLVLYEFEEIKAAIKMDREAKDRVGWLALVTSRGNRKRIGIIIAIAWFSQWSGNGLVSYYLNQVFDTIGITNTDIQLLITGILAIWNLFWAVFASFQVDRWGRRFLFLTSACGMTLFFTLQTICSAQYALHGTQAAAHAVIAFIFLFYAAYDLAFTPLIVSYTLEILPYSLRAKGFNVFNFTISLALIFNQYVNPIALKNIGWKYYLVYCCWLGFETVYLYFFIVETKGLTLEETAALFDGEDATQLQKVAHQAADVRHEDYDEKSSKPEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ58</accession>
    <name>A0A2G8RQ58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ58"/>
    <dbReference type="OrthoDB" id="2753605at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="214" mass="24086" checksum="71B1F4D01D1AEA80" modified="2018-01-31" version="1">MVSAELRRRYFTLLRSFFSVRAYDVHELLQSHRAIISGSTALAFFSWTDSWTPGDMDLYVPDSSYERFVYELEHNHLGWFEANLGSQPHSDYHGIVAVRRYVTPTGERLDVIQSTTSNAANPLLHFWTSAVVNLISPFGAVCAYPNATLDHKALISDISRSQKLVVARSKYEARGFEFAQVNTWRPAADGEGGLMLSNQPILGLAGYWLHTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQH9</accession>
    <name>A0A2G8RQH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_13507</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQH9"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013909929" evidence="15">
        <location>
            <begin position="31"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL23757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="519" mass="59455" checksum="796FA6400A663C2E" modified="2018-01-31" version="1">MDFLFNSGLLPSFLALTVVLFLLLVWRVKASHLNAHLPPSPPSDPFIGHCRIFPRSYQAEVFFEWSKTYGDIFYLEILGRKIVIVNNYEMANELMDKRSANYSDRPVFPLFMNLGWGISVTFLRYGPQFFKQRRILQQYLAKTEVPRFRPIHTDEARKMLKNLVDRPADFDWLVRRYVSAAAFGAAVIMKIAYGHEIERDDDEHIKMTENVSLAHVDAGDPGTAPVDFFPILQYLPWWFPGCWFNRVIHNWSWAIKKFHDYPFEQVQRKMADGHAPPSFLLTYLEEFSKPDYTGEHSLDDLKHATGAIYAGGAETTYSTINTFILAMVLHPEVLAKAHEEIDRVVGPKRLPDFDDRENLPYIEAIFQEVLRWRPVVPLGIPHSTMEDDTFNGMFIPKGTMVFANAWSMAMDTRVYHDPELFKPERFLPGTHGAPEQFPHASFGFGRRICPGRFLGMNSVWMAIVSLAATMDIRKAKGPDGEEITPKGEYTSGLSSFPKPFPADIHPRSAEARCLIMSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQV2</accession>
    <name>A0A2G8RQV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pirin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_13646</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQV2"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="66"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="228"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL23895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37588" checksum="90220EC86EE0F25D" modified="2018-01-31" version="1">MFRVSPGIKVCATLLASSSSFHPNPLHTHSLRTSSFLSHIARMSTSRTVAKKVLSVETEEGAGAIVRRSIGTPQLRNLTPFLMLDHFTISKGAGFPDHPHRGQATVTYMLEGSSRHEDSAGHKGEIKAGGVQWMCAGKGNGLTSFKVIHAEMPVSGDGIPEPRGLQLWIDLPKQYKMVDPSYQELDPKQVSEAYPQGEDGPVKVRVISGRSHGVESPVRPLGGCWYFHVIFKKPGTIFQEIPAGWTSFIYTLKGGLKVAPDGSAHGPFHTLVLSAGSGENGAELTATEDNTEFVLVAGEPLDQPVVQYGPFVMTSREEIQNTIIDYQFGRNGFEKAHNWKSIIGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR39</accession>
    <name>A0A2G8RR39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR39"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR39"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="7">
        <location>
            <begin position="113"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL23980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="509" mass="56610" checksum="4F2A2E442A1D32F3" modified="2018-01-31" version="1">MADIDEDVIVVDDVDDNDNDAFQPSHRAATSNAPQRSLPPRASRAAANLRRQSTPPYVDPSEGRTTRSAARGPKPQPKLKLKLSEKAAAQAPGMSFLGPYDRELDSDDEDLVFEEQFILRLPPGEDCEKLRKMVQGREVSDDVWFKFKDSRRAIFHIGDNTYQSKLVDLPCLIESQKTLDNKQMFKVADICQMLVVEDKIPDEGSMTGRGTFNIDEFIWPHGITPPLKHARKRRFRKRVNRRVRVFPFLSLPPHPPTFLFLVKLCALTSFLRQTIETVEQEVERLLEADALASDVKYDVLENVNPDLSDSEFVDIDPDAPLDPATPGFGFDATTPAAQADADEDDEAPAARDDDEVGEGDIDEELAAELDLALGDEEGGADGDEDEDEDEDDDEDDESDEDDDDDDETVQARKLLNEEIRDLEAAVNKKQTEIASSGNPLIKRRFEDALKKLQADLDTKMAQRDEMKEKSRLRKQGITPGAAAGGTDAEDFGGDDDDLFGEGPDGMEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRC6</accession>
    <name>A0A2G8RRC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRC6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRC6"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="102"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="480" mass="53203" checksum="0F7FE7337CB617A0" modified="2018-01-31" version="1">MASPSLALGDGPNASRFTITDNELVVERDADKKWPVIRTLLRNVLWAGIDNGNQLHVSLLAKKKRTSPMALVHVAGTVPDPDIATATAFTDSVMQSAYYGLTLRRRLKVIINPKSGPGKSAQIFRKKIEPIFRAARCPVDITFTERGRHAQDVAQTLPLDRYDAVVVLSGDGIVYELLNGFAAHADPARAFRMPIAPVPVGSGNGSSLNLLGKADAKDKAMAALNAIKGRPMSVDVMSVLQNGQRTFSFMTSCLGLMANVDLGTENLRFMGPQRFFVGFLREVIRHRPYSYRISIKVAETDKDKMMQNREALRAQAQALHGSPISTYSSSTLPETGVPELKHIGPDADRDGWITFDKSFSYFYAGKGPFVSVDLMQFPVSHPDDGFIDVVIAERTTRLALLKAVNGADRGTQYWTPVQHYFKAYAYRVEPISPDGYLSIDGEEYPHEPFEVEVHQGLGTFLSMYGHYKNEFRRPPEPEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSN3</accession>
    <name>A0A2G8RSN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_14278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSN3"/>
    <dbReference type="OrthoDB" id="2748580at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="318" mass="34863" checksum="D5C4E4EDBC94F9FE" modified="2018-01-31" version="1">MTLTILQITAIGILTHVAFMHGENGLCHWLTTSSLVWGGKLALFQLYPDIWFMRKRLKTRAEPVQGVPVVRVCPPDHATFMNLLTFIDALLVAIWILLQVGVLVVHGKQCYAHAPLVSTLAVVLLALALLYYLPTTLLLIFRRSRESRSDGGDNIEIGPLPQSKVDRIDLVYYIPPPAPAPALAARPSGPVAGLRRFGPTSRGLSATSDDNNNGEWEKSFQRMPRAFLRIEKHEAQCAICLDEYTAPPRVTGEEEGAIPGSATSASAAADAQGVPEPLRWLDCGHVFHKRCIDPYITTKAAKCPTCRAPVKVQSKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT64</accession>
    <name>A0A2G8RT64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12558</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT64"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT64"/>
    <dbReference type="OrthoDB" id="2663142at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="54793" checksum="2C7B2C96286E3B0B" modified="2018-01-31" version="1">MHPALCIDEVLQLIFDFCGDLRDSEPKWTYGQLARCCKTWTDPALDRLWRRMGGLKPLLALLPKSDECIAEATPTVEDYAKRVRHVVYADGFVSVPSLKLSEEHGPNVFPHLESVSLVNAGCLAPPAWIHSPFLTRVAVNLSFSRKPHSVFDRSAAVARFLPTVPQLHTLQLRGRMSVTLNAVLASLTQLRSLTVHTGDSLGCDTLAAIATFPALRILEVHASHIDADELKDTFAMGDAAFFPALEEQSIRTNAPLLATLLAHIPSGVLRKLSLDIDGDGDANQAALEARMKPVFELLAQKAAGSLHDLLIEDRTVHDEEQDGNHARGYALDVLSPLARVRQLRSFILREPDLFDKDLETMARWWPVLERLDLGTPEGCGAPEESDEMQADEEHGQAAVAQAMSQMTSEAYRIVARSFRFLESLSLGAIAPCEVVPVEERTKFVTQLRCLTVGKASDVTGKVDAPAVVAALLSIFPTVTSIDCPDAEVSARFEVAVAGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTX1</accession>
    <name>A0A2G8RTX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTX1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="109" mass="11189" checksum="3F66527DF9DD2CB4" modified="2018-01-31" version="1">MMLDRRTYVAMGSACPDRSRPKGGTVEDEEAAEGGTVVSEGSGAAVEEASGEATSRVLSGDCTRAASSVFPDDLNSKGDWSSSDAGGGEVASRGCRRRLRLRSIDSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUW3</accession>
    <name>A0A2G8RUW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUW3"/>
    <dbReference type="OrthoDB" id="2741677at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="201" mass="21741" checksum="01AB9EB67954E63F" modified="2018-01-31" version="1">MSWNADVHEWLMIHHTIASNSDCGAHKYHVFAVAEYPIFGSKSKYINTNIGIPLGPLAVEFAGQIDIRECATCVSQLTVNVKYPLLASVKAGTYKGDLHCGCGIDLAIGVPEIYGTLRFWVQGGDACHPTAWLWVEFDLHVFDVEYKGNRCQWFPSPDKLIEGAATPSAVAIASPSISVHNETNNITNIVAPTVAVAAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV77</accession>
    <name>A0A2G8RV77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV77"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV77"/>
    <dbReference type="OrthoDB" id="5404599at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="31967" checksum="AF5CC6AE90ECAFB0" modified="2018-01-31" version="1">MLEGEILDVKQYPTVTSTLWAAWRLMPRFLRLKVYQCIMHFGGATSSSRVTCLPFGLYAKHGPNTSVAEALATQYVSTRTTIPVPTILDVLLDSAGAPLILMTRVPGTPLGGMPLTADELSDAQLRAFSDTVAGWLAQLRQLGPPPSGSAVCGFMGTSIMSYRIDHSKNVGPFSSSDEFHSQYCCTLPPEADPGIRALAKRIREKPYRVCLTHGDISPTNILVNEDYVPVGLVDWGCAAWMPEYWELTSSIYCRQLYLGWVHIFKAAVPQYEEELAVEMELWKFISPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVF9</accession>
    <name>A0A2G8RVF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVF9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="339" mass="37319" checksum="BB562EDA016C3889" modified="2018-01-31" version="1">MSDNGPNDLEPRSPFAPAEVTSGNFAMNPHYASSGTQAARETPLYVHSFFAPPAWSGPPLYPSPPYSAKHSGPHVPQHPRDSPNRFAPTYPQAWAPQPQPQLPAHIPDVFPQVVRGTDVRNVRYAAPPVGSPCPRSDRMPPYNGPSAPPSGSSDTQKRVNGDAMRYAAHDSQVPGPSTLVVQVLEEITHSPETPASSACDFDGTLTLGDALRKTFSRISGHGSRRAFPGYRFAAKMTFLHMFNPDLGSSYRPRKKQVTVVTTRRSVVQQPSEARLAYLVAREMEKYLKECELRGKPFPYSLDQIVLRRIDLASRGTLRPRLFPRVRPPRSVRSSSAATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVN8</accession>
    <name>A0A2G8RVN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000046">
        <property type="protein sequence ID" value="PIL25567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVN8"/>
    <dbReference type="SMR" id="A0A2G8RVN8"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="365" mass="41454" checksum="F4B7D359050BD14D" modified="2018-01-31" version="1">MGSPSTSPQTYLRISDMLADWPWQRRLNPHYEEVAAEGDAWLRSFLALTPKSQRAFATIKASLMAALVYPDVSRDQLRTCVDFLNVFFLVEEYTDVEDAEGVRRIVEVCTDALRNPSKSRPDGEVVLGELMRQFWDRGRRTVHDETGKPFVDSAIDFFNAVLVQAEARDSGRVLTTDEYVAIRIDDIGVRPMYALGGAFLAIPDALYDDALLTKMMHLGCEIITIDNDIVSYNRERANGNADFNIVTIAMHHHGLNLDDTVRSLVEKNARLEAQYMQCMREFCSTLERRGGADETASIRGYLDHMGNVRRGLWSWSFECGRYFGDRGSTYAKTQMVPLVPEITRDTSLRENQVDILLMEEELAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWE3</accession>
    <name>A0A2G8RWE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWE3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="88" mass="9837" checksum="DBF436FE690AD94D" modified="2018-01-31" version="1">MAEHKLPDLTVRGYDPRKGPYKRVSPDVGDDGGLVNNREGLYTPDNFPCWNKGRVKVEQSVFTLSAVWGHLWGILGVLMGIPWQLICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWW3</accession>
    <name>A0A2G8RWW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWW3"/>
    <dbReference type="OrthoDB" id="2765710at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013930146" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19190" checksum="3701277CFDAD907B" modified="2018-01-31" version="1">MFLPHMSMSGAAWTGLLGTSLSTAFGAGGVHSPNFSVLPPSLSLLRDVFNTGRHIAWLTEHHPPAQGVSRSVDRKPTWWLSTFALAPLRLPPSSRITSLCRRRGGRANAFPIQSPVRDGRLGLRGVGVSHCKAEPPTACTGINGASLADIGAFGSQIQVPELGTIPKDGQAFGDGVGISLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXM5</accession>
    <name>A0A2G8RXM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXM5"/>
    <dbReference type="OrthoDB" id="2755266at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="220" mass="20849" checksum="DD4A0B4CC93FE782" modified="2018-01-31" version="1">MLYKPSAVFVLLSALSHYYVSGAVVSLLVPLADGDEAVTGQFLGTDAAGHTSWSLGPGVPSGAFTNTDFAAVTLVADATDVHEVGALSTVLQGVTVTLTASAGCAVATGANGSPVSAVCSGSAEAVGAFSGTSTTNVVATTFTSLPPMIAVHVADSGSGAVPTAVSTSGSGTATTSAGGSASTSGAGSAPASTSTKNAAAKERLGWGVVGAAGLLLAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXT5</accession>
    <name>A0A2G8RXT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXT5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXT5"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="48"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="347" mass="38475" checksum="B2D47E55311D6402" modified="2018-01-31" version="1">MQPSSDSSDGPLRKRPRIDDSGDEAGSAATETTQNTRKRDDEFWFEDGNVILVAHDVEFRIYRGILADHSPFFRDMFSLPQPPDHEPPEADSATCPLVHLADSPEDVRCILRVYIPRDDSSPFAPDSPSFDFISACIRLGHKYQMAKLLDHSVAYLKTWYPTDMASWQKQYSDRENHTSPGFDHAHAIGVVNLARLTGESSILPTALLDCCLLEEEVLDGFDRADGTHEELAPTDLRLCLKTRIGLAAARVSIFARAYRADVSKGCADPASCRAALRKALALIYDLALELSATDPFKPLSSLDDSHGISLCPLCFSAAMERGKEEQKGFWNALAEAFEIEVEGWGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY54</accession>
    <name>A0A2G8RY54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY54"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY54"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="44"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="362" mass="40361" checksum="622CD487C1AE3041" modified="2018-01-31" version="1">MDAGPSKKRTRTNSVPEDISAPPTTGLDKVKAATRDKDYWFEDGNLILVSQGVAFKIYKGLLAEHSTIFRSMFHIAQGKPETDDLVDGCPVVTLYDSPNDLRELFQLIYPLSTNVKFGTGQKINISFISAIIRLDHKYELKGVYDQAMSYLTTYYITNFGAWVDGRNAAQWQPDPIHAIGAINLARLTNTPSVLPFAFYICATLGPDLARGFVRPDGSVERLTPDDMRICLEVKARLATENTHTAFLLFRLAPQHCSHATGSTYCADVWRKILEHAGLSKAPHPVASERALDSWLGNADCLPAPAPLGPGVSFSAYMASYSPQRTLCKGCRGHLEVRDRELRRQIWRRLPEFVGLTIENWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY56</accession>
    <name>A0A2G8RY56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY56"/>
    <dbReference type="OrthoDB" id="2929525at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="302" mass="33142" checksum="61AB8923E6AA97F8" modified="2018-01-31" version="1">MPLSNDAAEISLGLLTTSLEDTIGAVLVATFCALLLYGISLNQLYRYLLQFPSDDRYVQAICTQGRAARIILNGQCDDDPMAPSYFAVVSNLTQKEALLNHAPWSENAVLIASAPILIVCQMFFARRIWIIGPRYRLIIGIGAVVLLTEFGFAIAISYKSFMTVLSNDTGGVRWLITAGLSTAFAADLLFTPTLTVALWLSRRGRQGKQGVAELFSTYIVNTVLANSLLSALNSRDPQKSPSIFDSGSYGRNLIQRMNHRAAAETWNVPQIPDEPSVIHINVMTENEGVMRDSQFKRGFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYF3</accession>
    <name>A0A2G8RYF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYF3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYF3"/>
    <dbReference type="OrthoDB" id="2756716at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35375" checksum="42E52E16A2748056" modified="2018-01-31" version="1">MMVESLWRNLKRLVLIMHNRPRIDFTIHSIITQTIPAYPVTLSKIVNDSRDGRAAAPTHMQAAFKASWERLLKVPVKGAYKTSTAKWTCDCGAQKYHAYLLCKHLVQAADRPPPTWWTSLVRYHIPPFYTVPTKGTVASPPEDRTKHAWVKRMPSFTHPKPEPSDAPSPLPPSSPPSSPGPAPDDEISRMGTPEPAENEVIDLTMLQSSSPIQSSPQKAPPTGKDGLMRSQTGGDIGFEPENARDLEKAELVRRLRKAADILEEQEDPRFIQNAKAVTKRVSDWVGEIELHENRRTMPTTNRRSASSTIGYKYASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ26</accession>
    <name>A0A2G8RZ26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_11112</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ26"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ26"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL26776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="369" mass="41936" checksum="A3BECF576291861C" modified="2018-01-31" version="1">MADAKAQKRQKFEDVFPKLREELLAYLNQEGMPQDAVTWFERNLDYNVPGGKLNRGISVVDSVEILKGRKLNDDEYFKAALLGWCVEFLQAFFLVSDDMMDQSVTRRSQPCWFRVEGINLIAINDSFMLEGAIYYLLKKHFRSEPYYVHLLEVFHDTTFQTEIGQLIDLITAPEDHVDLSKFSLAKHQKIVIYKTAYYSFYLPVALAMYMCGIPHAPSSPSPSSSPSADPYALAQSILVPLGEYFQVQDDFLDFAAPPEVLGKVGTDIVDNKCSWCVNTALALAGPAQRRVLDENYGLKDREAEARVKALYEELGIRERYAVYEEGAYGRIVGLIEGIPVEGMEVGAGDVRLKREVFKTFLDKIYKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ81</accession>
    <name>A0A2G8RZ81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ81"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="101" mass="11148" checksum="668686416CF64F83" modified="2018-01-31" version="1">MNVSDDERKYVLGIGCRFEFENTWVVLPLTLTLRRSGAGRGREPRADYRRLEFGFGFMVGAVGRGRRVSTSGCGVAERGRGRGGGEGGMQRGRGLVHEGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZM1</accession>
    <name>A0A2G8RZM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZM1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="61" mass="6373" checksum="301ED74FBFFF5C74" modified="2018-01-31" version="1">MTMARPFNHSGLSQMLAGDAGVGRPAPARLKHSGATSRPAPSGPCTKGFLETYLFRLTTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S026</accession>
    <name>A0A2G8S026_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phenylalanine ammonia-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S026"/>
    <dbReference type="STRING" id="1077348.A0A2G8S026"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="78760" checksum="A48CEEC0E0B03AB6" modified="2018-01-31" version="1">MPTTFSKADVAVESSSHLSKKSVTPSHPYAESTAVKDVATATLLRSFLEAHRALHDYKQGQPIVVDGQTLSIAAVAAVARYSASVVLDDSSDIQTRVLKSRQVIAAKVTGQKSVYGVSTGFGGSADTRTSDPLTLGLALFQHQHCGVLPSDTDATSMVLPLLDPLTSTSMPESWVRGAILIRMNSLIRGHSGVRWELIERMGALLRENIIPLVPLRGSISAPLPALVHRRPAHREPLHPRLRRAPDPRGRRIVSSREALAAHHIEPISLASKEHLGILNGTAFSASVGALAVYEAVHLSLFAQVCTALCTEAMLGARGSFAPFLHAVARPHPGQVEVAETIADLLEGSQFAVTAEEEKHISADIGELRQDRYPLRTSAQFLGPQVEDVLSAFAAITIECNSTTDNPLINGETGEVHHGGNFQAMSVTNAMEKTRLALHHVGKLLFAQFTELLNPTMNRGLPPSLAATDPSHNYFAKGIDIHAAAYVGELGYLANPVSTHVQSAEMHNQAVNSLALISARATLNSLEVLSLLTASFLYVLCQALDLRALQHEFQLEADSILRDELARSFGAHLAEADLAALFAAVARQVRSSLETTSTMDAAHRMRAVAAATTTPLVDFCAGRAGSGGVHVDVDLNEVVAFRARLAERMTDALVRLREAYLRGAKGPAPAAPYLGKARGVYEFVRTTLGVRMHGVENLSGFEGGAGVEEPSIGQDISVIHEAIRDGKMQDVVVGLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S059</accession>
    <name>A0A2G8S059_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S059"/>
    <dbReference type="STRING" id="1077348.A0A2G8S059"/>
    <dbReference type="OrthoDB" id="3248986at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1066" mass="118707" checksum="A0196C65874A04AB" modified="2018-01-31" version="1">MDEESRWQQIVECRCQSHRCGKTIRGFRWQSRQVRRKHEREDERRRREVGSEELVPTICAQSGACPIAFSGELDLGQTTLADCAEAPSPEAPSSPGQDLVTLPESLLDDCISEFTGDDGLSSSGDDSGPPSGDPPSDSLLGGSSPSPSPPPTRQPTPELQSPSDTSRLKAQADFVLDPDSRSTVPPAFQENPGIRLLYMQAALGNIFGSSTVDQATKQISDGLDIIEESAGSLPAFPKPARSLATVKRRLGLNVDDYIDRRAICTVCYKHYTLAEIAALPSPSCSIQRCSGHVYSIKRDGDGVEKRVPAKIQSYSSFMKALQRFLLRPDFVQNLIFPSSFPDRRPLREDELMHDFHDGEAFGNLVLGLERIKLADGSIADCQTYIGTPITLKTVPYGLSLSIYIDWYGVVSGRPHSTGAVYVAFNNLDRSVRFLQRNVHLATNIPGPKEPSLEQMNHALEPIVAEISTLYRGVTMAMCGHEVPIEVFGGIESRVFDVQGARKCEGAAAHSHNIHPCNLCLILHSDINSPAGYDIENFRIRDDFSQLAAAWKSREAKSERARKKILDESGSRWTEFMALPGWMPVSGAAVDFMHNFYLGIVKSMFIDFLVNGYCLDKRMWETLEATVNSIKWPSGIGRLPTNLAENHSLAKADQWRRWANIQYTVLWICWRNQHDGIPACPPDVPGSAKKRPTFTRTSLPAIYDVFLKASIVERTLAAKSISMEDVNRGHNHLVHGVCQAMLRLGVHLVPNHHLAMHYPRVFRLGGPSYAWWLYAQERFNGEQENVNHNGHAGGEMELTLLRNWVAKHRLYELVSSLPASATAKERALLNRIIHGDGPARGTLRTQLAGFAQGDRVYRPKLSKHPTNLRKLPDTFVYRLLLDFARQTWPASRVIDDLDDESFAGPTAIFMADRSAFKIPFVIKGGVRYGSHADKRTEADEYACVDFDDSRIPCRLLYHFELHVGTEAPVLCSIVQRMCADDKIPVFPWSLYSTELGIYVAYADQYQPPEVIAASRLSAAVAVLPFTSHALGDEQPLWAVHSFDRTGIEPDDDWFNTLADELGLQQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S075</accession>
    <name>A0A2G8S075_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S075"/>
    <dbReference type="STRING" id="1077348.A0A2G8S075"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013883348" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="13307" checksum="1ABC535D5385B377" modified="2018-01-31" version="1">MRFATVLMVALSAATSGFALTKKGGNATTYDPGLGSCGVFSTAAELVVAVDAHTINNFPGAGSDPHLNPMCGRKLKVTYKTKSVNVKVVETCPASKCKVGSVELSPTAFKHLAPLSVGTLHNITWTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0T1</accession>
    <name>A0A2G8S0T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0T1"/>
    <dbReference type="OrthoDB" id="2798001at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="28589" checksum="E94851A1B3489C59" modified="2018-01-31" version="1">MAGSVFQNSYYIANTINAILYGIELSLYFMVVQRLLALGDRRTSMDRFMMIFSTMLLILNTIFWTIQVYFGQRMWINNPDYPGGIDGYWQDNSSVWYQTWGTTACVASNLSFVVWDSQRVTIVPSLLWASSLVFGIGLLYGSGRPNGDYFAGLAAMFVTAYTASTFAFNVIVTGLICGRLAYIQRYMQTFYGADRRFYAGAVAIVVESALPFTLFNLAYLVAFAVGTDIAFAFSFYAMFTVSSSLPSFFSWHRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1I1</accession>
    <name>A0A2G8S1I1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1I1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1I1"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="15248" checksum="D5098DDFCD750B3B" modified="2018-01-31" version="1">MTPLPDMESETLMPTYRKLPDEAFERVGRRQQSRPSHYRHVLVRSRIPGHLWINLTPPLYSVILGRAIKNEYLALGTIFGTVGLSMLATSGGKKEAPAAKPTLAQVKDTVKIDASSKEEEEFIRSFIAEAEKDSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1Q8</accession>
    <name>A0A2G8S1Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1Q8"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="430" mass="48115" checksum="20C52737E4AB9A88" modified="2018-01-31" version="1">MQQPTLTNIRIRSTRDALQIFFAVARNILPMTTRRLDAEERRAISSGCVYIWEERCANSEATGMGMERWTDGMGWGPSRVRDEFLFYHQRENEVHEDPNNPSARWASMMRRRDTRSNLPFSRQDAERLIKQTYSVHVSLPEDRPRGITRKWHLTAYFSQTTLDSLGTIDAIPSVGDVQVPEGMFKSARASKINKRNDPMPEDIGAATHEPWGINIPPAASHPSMPPYGAETPKWANASPRLSNSPHHASGAYAPPHNPYPTPRSSYESADYARPLSTHQPSIAHYAPPIAVHPSHPPPPPGQLPTLHDSGLAMYRDPSPYTQSSSSSSEPGTSPRTFSSPLTPPSSTSLPLSIKSEKQQALPSGPKLVPLSYLQGLQSQGRQQRDPMDVLYLQRFSTPEKEPNRHSWASSPPYDRFGEDEAKPTLVDSRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2Z1</accession>
    <name>A0A2G8S2Z1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2Z1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2Z1"/>
    <dbReference type="OrthoDB" id="2751896at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32424" checksum="E7B60B07456378BC" modified="2018-01-31" version="1">MPSIKVDIDAPNKPPNFPSADEILQQWRERLRLAEAANPGEHIRGVLLVDGSGAPYAWLKFGPTVTMAEGRTQHFVAQLVNSDAAAPVRVPYVYLTFEFGLRGFIVMEFVDGAAPAYESERDVADAAAAVRYLTGIRAPNSVPGPIGGGLIRHPFFQDRESAVAYPSVDWLQLHVNRASILRLAYGRAGGSVDFSAEVEAHGLRLCPADLNRENFMKDSTGGKIVVLDFGATCFLPVSFFRSAFDISADHFTMLLCSQITEPPESRNSEGVTRASYALVPRGSNWFGLPKELKPLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3C5</accession>
    <name>A0A2G8S3C5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3C5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013923533" description="Transporter" evidence="2">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9578" checksum="B6F40362E8856DE7" modified="2018-01-31" version="1">MPAFHRLLVLSVLALALSVQAAPLGTVESRDLGNVSGFEARGLKPKPKHSAGSGHATQHVGGGHHGRDVEEDVEDALEARDPKHKLKGYGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S454</accession>
    <name>A0A2G8S454_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S454"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="159" mass="18077" checksum="C0A50D55A709A93F" modified="2018-01-31" version="1">MSSSDPWCAPSPPDKRQKWYLAIPWTGELLWHVLDIRAADVDSDSTTDPAVSARIARAKADKDQDYPSYLFNWAIKDIGGIIEKKNLGEEIPEIEMAYYNPSKTRMIAMLVLRTKRGDSESDLDESPDLHEPRATDAHVEALRSKGWVVGWYRAGPNWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4T6</accession>
    <name>A0A2G8S4T6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4T6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4T6"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013890073" evidence="5">
        <location>
            <begin position="20"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="90"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL28799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="415" mass="43518" checksum="C00C6A7624A24F08" modified="2018-01-31" version="1">MARLSALFALAAAAVAVSATPIVVRDSLVTLPIARRFNSTGAANIVKADQARAKTLKARLQATKVSPVDTAAGKIFPGINVPVTNQAIIYTASVGVGTPPTSYELIVDTGSSNTWVGANKSYVNTSSSVDTGAEVEVFYGSGFFFGEEYTDTVTIGDLVIKNQSIGVAEIAFGFDGLDGILGLGPDDLTEDTTSVGGEVPTVIDNAFAQGLIHAKVVGVSFEPTAQESVTNGELTFGGVDYKKVTGPIKYVPITSTSPASDYVGIDQSITYGSSRIPILSATAGITDTGTTLVYIASDAFAAYQNATGAVIDNNTGLLKITPDQFANLESLFFHIGDATYEFTPNAQIWPRALNTLIGGDADSIYLVVVNLGSPTGEGFDFIDGYTFLERFYYVYDSANACVGFATTHFTYATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4W6</accession>
    <name>A0A2G8S4W6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="12">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PIF1</name>
        <name evidence="15" type="ORF">GSI_08857</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="12"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4W6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4W6"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="81"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="12">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="383"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL28812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="615" mass="66442" checksum="D564E2AF31E42A33" modified="2018-01-31" version="1">MARSAVLSTTTATNTKKRKSTGGLDASGKNDDTSNKRRKTLDAFFAPQVTVKFPTKEAKGPVEVVALNSEQRRVLQMVVEEGKNVFFTGPAGSGKSLLLRAIISGLRKKYSKNQAVISVTASTGMAASNIGGMTMHSWGAVTPGMHNIDRQISCIKTCKPAFKRWRETKVLIIDEVSMVDGELFDTLAKLADQLRNKRTDKPFGGIQLVVTGDFFQLPPVTKSSAEPFFAFESESWKKCIDHTVTLTEVFRQRDTQFVDLLNELRKGNIAPSAQQTFTTLSRPLPPLPSGILPTELYPLRAQVERANTTRLAALPGSVSAYVARDTGTHQKVFEQMVVPARLALKVDAQVMLVKNVDETLVNGSVGRVLGFHTIAACAASIGTPTTSQDKDVKPFSGFGASSSGSRAKPASAASSQESSASSKANGAVRNVQVDTDGRTPVSLSGRTLADKENAGAEQADIKPMSAKGRPKDDELYPLVEFRTQQGTEIVLVVRDEFRVEDNEGKLLARRVQVGQGSTLRGCLNEFADVGIRIGMQVPLVLAWAMSIHKSQGQTIQYVKIDLRSVFEKGQSYVALSRAASLDGLQVLGFDPKKVKAHPKVVEWSSGLEVAASADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5F7</accession>
    <name>A0A2G8S5F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5F7"/>
    <dbReference type="OrthoDB" id="2747999at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="326" mass="35501" checksum="EBBCB8197E7AA094" modified="2018-01-31" version="1">MADYRALIVADVRLSVTSVNDIITSLQRETPLSSDIIQMNYPQSTIDEFIRSSLAVVDSIRSASERASSWLADTGDRLSQNLDEARRVEDDVRNTSSLLRDAEENIRATEENIRTSETNVQHAQNGLASAQSALARARDRMEEAENTHKAIHIGSMIAMIFMPIVAFGVAAVNMAAMSENLDNHYDAVRRLESELSASNTELETRRGTLAQQQGERGQLELKVAGLRSRASSLAAEGRTLSEARESLAELSRRINDCLYAVNAALSSSTSIAAMCSMRNVVTGIRGVVGGLGRDEMFAGPLTLLDEGAFGALDRRVATIRRSRLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S623</accession>
    <name>A0A2G8S623_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S623"/>
    <dbReference type="STRING" id="1077348.A0A2G8S623"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL28988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="63" mass="7119" checksum="F33EF01AC96533FC" modified="2018-01-31" version="1">MGKVHGSLARAGKVKSQTPKVEKQEKKKSPKGRAKKRMVYNRRFVNVTTLPGGKRRMNANPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6H2</accession>
    <name>A0A2G8S6H2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_09187</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6H2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6H2"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013863107" description="CFEM domain-containing protein" evidence="15">
        <location>
            <begin position="17"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL29138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="161" mass="15182" checksum="FA9476C2D54C9F29" modified="2018-01-31" version="1">MRFFFAVLALVAAVSAASLQRRQSFPTCSESCLTNANFGSCDPLDDSCLCHDSGFVSSVTNCIVGACSGSDLTTAEAAAQQLCLAVGVTLTASSTVSGSASATGSAAGSATATSPASGSGSASASAASSTATTTSGSNGAASHGVNALAALAAVGAVALAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6U1</accession>
    <name>A0A2G8S6U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6U1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6U1"/>
    <dbReference type="OrthoDB" id="3215905at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="581" mass="64450" checksum="B3507C51D0B434C8" modified="2018-01-31" version="1">MRSIEEITAALSPLQPSPLSRDEILCFFAYLPASPLLIARTGAPWKPIPLTTQWYVPYKRELRPVGEHPIAAPGVWENHVGPALLAVLDQENVQWNTIDVHRIHYIEFDHEAPFPVVVCIGVKFGLLTGQDGARVAERCQAVLDDFGLADVEVAIKASERFQLAAPAFEEPGEWIRPEKDPMAKSRMPFTFCVGFPLSNQARPGVQGSGGFFFTNGEDTSKVYLVTARHAVIETTTREKNTVYDHNSSARPRRQDVTLFNEQSILDHMQTIRAELGSQSIDAEVYQRQVEYMQGKLNDKMQAGADRIPIALIRHQDTLERAQESMVALETFYADAAKLYLSDLGRLLGFVSYAPPIGFSVGEHKYTEDVAIIELDANKIDPSTFRPNVLDIGSERSLGDLTAMMGPRGSRGEDRASPIPFPFPFPLERLLELRGGIVPDAELRAPQQKDFNDDPCLMVLKRGAASGVTTGRLNNVPSYTRTYWADGTSDVSMEWPIFGYLHEKHKYARSFSERGDSGAVVVDGAGRIAGILTSAAGLNDPSVKNRTSPLDDEANVTYMMAADFIRDQMLTRGVDMNVNFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7L4</accession>
    <name>A0A2G8S7L4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_08190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7L4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7L4"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="12">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL29751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="97" mass="10707" checksum="7F5F7F4CF54384CD" modified="2018-01-31" version="1">MATIRDLVASIYFEKQEPGTALCAQHALNSLLQAHYYSPAELADLARDLDQDENLALDDDAPAATSNNMDDSGFFSVQVMQRALQNFGLECAFIHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7P0</accession>
    <name>A0A2G8S7P0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7P0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7P0"/>
    <dbReference type="OrthoDB" id="10267950at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="2">
        <location>
            <begin position="201"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="338" mass="37185" checksum="CC3326CDE05DFCE8" modified="2018-01-31" version="1">MAAQAEIVAKLSDNFEKARSSGDLLFFPSSLHTHSENGVEFQIRLCPALQDKPRLPTPDFGPDAPPPEEQEKKRPDPFAPPYNANLFLGEVRDEAEGNEYVILFNKFSVVPHHFMLVTKEFRSQTSPLLPADLVQTYLFLVAAKKAGRKFFAFYNCGDLSGASQPHKHVQFLPLDDDGPPVERLARSTKLDHDSRPFSITTLPYANHVRRLPSSLAFSSPDELEPVLADAFLSTLDLAIQTVRHDASYPAGAPSFNVLLTLEHLHVVPRRHETHVLAGTGEKLSVNALGFAGMLLVKSERELAAVKEEGVGNILRGVALEGGLEATTDAHRVADDQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7U9</accession>
    <name>A0A2G8S7U9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_08069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7U9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7U9"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="10">
        <location>
            <begin position="37"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="8">
        <location>
            <begin position="565"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL29862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="845" mass="96412" checksum="3DBC2F3FA8CF347C" modified="2018-01-31" version="1">MDKDNRDDFTFAKLSDLKMPVTFRISQLEGIRKAHPFTEVLEKPELRFHGIQQAPDYSDLYVTCQLVADNKPLTIPFRTAFKAFRNQYTWNEWITLPIRYCDLPLNSQVTFTVWDIAGPRSAVPVGGTTFRLFGKKWTLRRGKHRMILWPDREADGANETTTPTKMGTRDETGRLEKLIKKYDRGDLPKSDWLDTLVFRKMGEIHKAETAKSENLFLYIDLPRFDFPVIFSEPDASNVPGPSTSPVAPVPPTPAPQTTAFTADSHLWAVVDPDLARENPVEDKHRRLVRSHRSSPYDRELKPNAKIRDELSVILNYAPSQPLTSEEKDLIWKFRFYLTRDKHGLTKFLKSVTWRDPSEVKQAVEELLPQWTEIDIDDALELLGPGTVDSRVRAYAVKQLSRADDDELHLYLLQLVQALKFESTASDQRSSRSATSAVSYDDSGLADFLITRAVRNPVLGNRFHWYLMVEVAMEDKVMAKLYGRVVFKFMNILKDNGDERRDLMRRQGELVDTLAKRAAELRTSKDPRPKKIEKLRAFLADGKSGLASMAPLPLPLNARVQITGIVADKSSVFKSNMFPMLLYFQCADGGEYPIMFKDGDDMRQDQLVIQLFTLMDRLLRKENLDLKVSPYDVLATGPSQGMVQFIPSKTISAIISEHGTLLNYLRAHYPDEGSVGTYGVEPGVIDTFVRSCAGYCVMTYLLGVGDRHLDNLLLTPDGHFFHVDFGYILGRDPKPLAPPVKICKEMVDAMGGVQSVHYQRFKSFCFTAFSILRKSANLILNLVTLMVDANIPHIKQRDVHEQVLGKFCLEMTEEQAIEHFERLLNDISPFTAVLDRMHDWAQYWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S818</accession>
    <name>A0A2G8S818_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_08093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S818"/>
    <dbReference type="STRING" id="1077348.A0A2G8S818"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL29884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="466" mass="51092" checksum="8BF778DCF3BDF2B5" modified="2018-01-31" version="1">MSSALRAAVQQSRRSVFARSARYASTSAKAPTLKERLAELIPAEIENVKATRVAHGKKSFGPVLVDQLYGGMRGLPALVWDGSVLDPEEGIRFRGKSIPEIQEALPKAPGGSEPLPEGLFWLLLTGEVPTQEQVAALSKDWAARAALPAFVEEILDRCPPTLHPMSQFSLAVTALNHDSAFAKAYQEGISKKEYWQPTFEDSMDLIAKLPSIAGRIFRNVYGGDKLPAIDLEKDYSYNLANLLGYADKPDFVELMRLYLTIHADHEGGNVSAHTGKLVGSALSDPFLAFAASLNGLAGPLHGLANQEVLLWLRKMQSKIGENATDEAVRDYVWTTLKAGQVVPGYGHAVLRKTDPRYMAQREFALKHLPNDSLFKLVAQVYNIVPNVLLEAGKAKNPWPNVDAHSGVLLTYYGLDQMGFYTVLFGVSRAFGVASQLIWDRALGAPIERPKSYSTEAINEIFKDKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S916</accession>
    <name>A0A2G8S916_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S916"/>
    <dbReference type="STRING" id="1077348.A0A2G8S916"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013788957" evidence="1">
        <location>
            <begin position="27"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="30"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="171" mass="18156" checksum="EEC94815731C2423" modified="2018-01-31" version="1">MTRLAYTLLALPLLLASTFLAAGVDATSQPDITAYLNAHNSVRAQHRAAPLTWNETLASAAQSWVNKCVFKHSGGSLGPYGENLAAGTGSGYDIAAAVKSWTDEVSQYNPNNPQPSHFTQVVWKATKQVGCAVKDGCSGIFDPKFGAAKFYACEYSPAGNVLGQFTQNVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9T4</accession>
    <name>A0A2G8S9T4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9T4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="11343" checksum="1A5CACA2A0EB40EB" modified="2018-01-31" version="1">MPANLVETRDDHRRRVALAHSQCRVVPGKRAKDGCGRLLRGPCPLAGFGLQGLLHGFAFAPCPRLGLALRLLLFGFFVPPLLLFGARARLGSGVRMPMASALRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9U3</accession>
    <name>A0A2G8S9U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9U3"/>
    <dbReference type="OrthoDB" id="2581931at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="74" mass="7639" checksum="B03821DC380FF238" modified="2018-01-31" version="1">MKHQVPDPTTEIRGAGAGENFAGGRDAARAMGKLQSDEKTVGLGVVNVEGRPGIMESTHIGLLDEHSNDGALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA23</accession>
    <name>A0A2G8SA23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA23"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA23"/>
    <dbReference type="OrthoDB" id="5976465at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="319" mass="35839" checksum="1B747ED5B2DE25E3" modified="2018-01-31" version="1">MSQASQPTALRFCNYCIRSPEDGIKLMRCTGCVDGPTYCSKACQKAHWSLHKVLCRSESSNKRLLENAPCAAPGMLHGFRSVEELTQTFNDYTGSHRWALQTAVIICTFLRTNSSTNLQGYGVRPDNVVPRFWFARATGEASTSRNPARTFAFTRMSWYEACRPKQLEGFAALHASSVALFRREDPDAPDATILALFTLEGGVHSALECFSYFQRYQIKSAIPRTMQESLTAPLKDLARMCVASLNTPFPIHTMPEGEKPGLPVPGRYVRENKSWVWKPLFKNWEDYFAGDTDCGPLVALEVLTSGLPPHYLISLFYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA32</accession>
    <name>A0A2G8SA32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA32"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA32"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="273"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="472"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="571" mass="60068" checksum="C6F34BFC3C8457AF" modified="2018-01-31" version="1">MSTHPEAFVLLHIPEVILSTSSTSESGTLALECVTLAPDNADKDAPLAASLSAADRSLILVLRLGALELPLDPARPISLRIARDGTRTYTFRSATADAGASVQEKLEHAADDPTATWLTVPVPSRPDPHRAETVEALDHILAQYADFDWETEGGAHHEAPPHPQEEEVEAPRPRADAPPEELRGKLVLMDEESGEIVGELPNRVRIKEDPALADAAYGKVKGGEPAPVMLELPEDVYDAYTGAGTSVVPYSDRSELDEAREIFVRAIPPEDQDWMTKSATLISHAISSSTSLLLGGFTSATNYYISHSSPAPTPKDGTPPPPRALLLLSHPRTQSTLSRAYAISGQAVKVSAKTVDIVEGLIKRAVGAPPDKAKAPPVPPRLQSSSSAPATSGLSANPPAYFGSADGKPPLPPRHSASASPTLGSGPPPPVPPRSKSPAPGSTPGTPAAASGTSTPAGAVKPLGRREKLALSANLILATVDDSIRRSWDVGSEQATAVVAHKYGPEAAKSTHLAAHTAKNVTLVYIDMRGFARKALIRRAGKHWIKARLGSPGGGREMSGLVVDKQEQGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB34</accession>
    <name>A0A2G8SB34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSI_05669</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB34"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB34"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000064">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1065"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1101"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1130"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1173"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="147"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="21">
        <location>
            <begin position="239"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="23">
        <location>
            <begin position="951"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="807"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="809"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="899"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="905"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="925"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="928"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PIL30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1277" mass="142883" checksum="CB2885815238DC9F" modified="2018-01-31" version="1">MSDDFVRLVSQANPASRRQYQPANTGYPPSSSPNAMDPFFDDDDDVPDSAFGQPAAMQSKESGLPFARSGATPAGVGNSQLSLPTTIQPDRWSFDDDHGSKSFAGSSSFPGPSTGHERKPPKAPKKKWKFKLPWQKKEEALTGNRVIALNNPDANSEFCNNYVSTSKYNLATFVPKFLFEQFSKYANLFFLFTALIQQIPDVSPTNKYTTIAPLAVVLLASAFKETQEDLKRHQSDSELNSSLAKVLQPDGTFADKKWKDIIVGDVIRLESDDFIPADVVLLSSSEPEGFCYIETSNLDGETNLKIKQASPQTSNLTSPHLVTSLHGALRSEHPNNSLYTYEGTLELVSSGGNPKQVPLGPDQLLLRGAQIRNTPWAYGLVVFTGHETKLMRNATAAPIKRTAVERQVNVHIVFLFIFLLALSIGSTIGSSIRSWFFSSSQWYLLEQSSVSGRAKGFIEDILTFIILYNNLIPISLIVTMEVVKFQQAQLINSDLDMYYAKTDTPALCRTSSLVEELGQIEYVFSDKTGTLTRNEMEFRFCSIAGVAYADVVDESHRGDGDDDKEAWRSFADLRALVAGEHNPFVDFSDASGSAERHVVNEFLTLLAVCHTVIPEVHDGKMRYQASSPDEAALVAGAEILGYQFHTRKPKSVFVNVNGQSLEYEILNVCEFNSTRKRMSTVVRCPDGKIKLFCKGADTVILERLSEDQPYTEKTLLYLEDYATEGLRTLCIASRDIPEAEYRQWVTIYDQAAATINGRGDALDKAAELIEKDMLLLGATAIEDKLQEGVPDTIHTLQMAGIKVWVLTGDRQETAINIGMSCRLISESMNLVIVNEETAHETQDFITKRLSAIKSQRSTGDLEDLALIIDGKSLTFALEKEISKAFLELAILCKAVICCRVSPLQKALVVKLVKKNQKSILLAIGDGANDVSMIQAAHVGVGISGLEGLQAARSADVAISQFRYLKKLLLVHGAWSYTRLSKMLLYSFYKNIVLYMTQFWFSFFNNFSGQIAYESWTLSLYNVVFTVLPPLVIGIFDQFVSARILDRYPQLYMLGQRNAFFTRTQFWLWVGNALYHSIVLFAFSVILFWGDLKQATGLDSGHWYWGTTLYLAVLLTVLGKAALISDLWTKYTVAAIPGSFVFTMAFLPIYALVAPAIGFSTEYRGIVPRLWGDAVFYLVLLLVPIICLTRDFVWKYYRRTYQPETYHIAQEIQKYNIPDYRPRQEQFQKAIKKVRAVQRMRRNRGFAFSQTENAARQDQARLIRAYDTSKTGARPSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBF0</accession>
    <name>A0A2G8SBF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBF0"/>
    <dbReference type="OrthoDB" id="2757857at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="453" mass="50041" checksum="6556F4C0DFE85CD1" modified="2018-01-31" version="1">MEINPRAGPSTFRPTPALGVTYLLDTEEQDVRIILPVPLPLPPVDDPNDEDYDPSADQDIDEDELEDDDPEELDGPPYPTPSSIARGKRKATEIYVVEDRDGEESRQSDRLRRKKARLGRRGRKEPEYICISSDSGGDEDDIMEIPKPASPAREKKVKLEREDPPAKPRVAASESKEEGEPDAEPLDESSGSASPDPSPSPEADTGSVERLRPNAPTWLELQLARIRKRYPSAKIEICYHYSIEGDVWKVKCCTCPKTCAVGPGYSLEYMNRHLGGAAHQAAMCRIPEPQARAAPSKRKSNDTQKGKAKVIPQLQAAPRRDLLQAQRHQPATGSGRYYSPAQPATPTGHGRGSGREKEPEMGPGKDGRDEDRDRDRDGDGDDVERFLDQLGLSVALAPKLRSFGFADDKRMSLMGRLSDESLGLLMEHLRKEGVDLVAAIMVREGLKRRAGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBT7</accession>
    <name>A0A2G8SBT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBT7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBT7"/>
    <dbReference type="OrthoDB" id="2748421at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="533" mass="60269" checksum="34BF6EA5E65F5151" modified="2018-01-31" version="1">MPPSREQAGSPRVPSNDGQLINNLPAELFVQVLEDVYWLRRRSEIDWEIDWDTNWTVPYQLVCRRWRDVICSTPQFWQRIDIRSNPRWLDLCLTRCDGAPVSVKVWNTTSPDGIFGTLCHNAASIRAFRLHCDFPYLSYLSGLPSLLATPMTILETLSVIVPFVECELDVPLTHHLVPRLTSLELWNCTAPRDLALYASLRSLTFVGTTWAISYSEFLDVLSKCPSLEHLSLDEDVLCPFAEELADHPTGTQHRTTPLVLPRLSSMTVHGLRGLLVHFLATIHVPQATTIELKNCFDEDEPGPLVSRLLVPNPQLRIPFLSSLRTVSLSCWDGNPFQLSLRGGPDGNALFSLDYGTIHDIDWPGNTYLERNLVAIIDTFPVAAIDTLEVEGCLDLVAVETWHRVFQTFSSLRTLRVKGRGTLDFLWSGLACATTSSLERGGAVCCPYLSEIEIDDRPWISASRFKFTASTGLFDIVRGTLSARENAGATRLKKLQLYLEYMGELWTRTSERRATWVEDVKALVEELDYRDWQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBY5</accession>
    <name>A0A2G8SBY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_05951</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBY5"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="143"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="224" mass="23827" checksum="93E49A780C5BE0B2" modified="2018-01-31" version="1">MSCDPDFTFSIDGHNMTVIEADAINHEALVVDSIHIFAGQRYSFVLTADQDIDNYWMRALPNIGTTSFDGGVNSAILRYSGAADIEPTTSETTSVLALNETDLVPLENLTPPGTAEVGGVDYALNLNFGFNGTEFFINDVAFVPPSVPALLQILSGTVAAADLLPSGSYYSLPSNSSIEISFSMDAADAPGAPHPFHLHGHSFYVVRSAGQTDYNFVNPPSATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCP6</accession>
    <name>A0A2G8SCP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCP6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCP6"/>
    <dbReference type="OrthoDB" id="2595178at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50002" checksum="8159AEFA09D4B94B" modified="2018-01-31" version="1">MSTSTTILLSETIWLCPRPLARTPGRFLLVPLLPEKPAPKSLPSDIWNRVLEHVFVLYNAPGVKSDEALRLKLGLLRISRAVNAVALPLFYAFIRVSSLCVLEKLATRLQAADKSWDSIRRIPYSAPGRWIHVLDLEHLQCTSLEAVLRLDMVLNELLPLVPFLTDLVLNQHTVLSRRALCGFTHRDGVQNMRFLKGIQLATSMRVDEDAFVELLRACTRLEELEILGTGVDLSELSTSDDDLLDPPPSVYPLRLPFLRKFVALSMPCSPALFALLQSPLPALRHLTVTPYDEIFVPGTLIPRFLRVHGSKLTSLHLYTVKQWPTMLFPSPATILDICPSLRHASLELPLPILMLSRSEHHHLEILSVPRPKSDYFGVLERLLPKLPKLRFVRARDVKWLRNGMSTKAQQAGVQGEMLLWKRKLGRRGIQLLDAEWNPGTEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD22</accession>
    <name>A0A2G8SD22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06343</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD22"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD22"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1053"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1074"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1085" mass="121934" checksum="7839569B02C567D5" modified="2018-01-31" version="1">MSSFSSFPAFASFPDLDPGPSSSTPREETKVGKDKGHKKSTRGEDGEDDNERKKKKHKYKHRVREDGGRVRHKRRSSSRSPTREWERYGLVDDERRKQEEDRGHSREDGDRRNAQQGLVYFTDQKGDPLNLRYGGLHAGDVPKYRLVGGGKRVLGLNPALSVVYRGRGGLEIGPFGRRKIPALGDSSTRALLAAPPQRRLIASSENRYKFQEVDGFIRVRTTKPSKDNQAYREIELAKQSLDSDESNLSEESASSGDESDTTPLTSLQSTLKSLEGRLSANPTDVPTWLSLLSHTLSTMPITSKNASRARADISLSVLSRAISTHPSNLRSRTLRLKYLKAGETVWEPGKLREEWEDAVKVDDIEIWMAWFDWRVRKTPNLLETITEDMERVLRTSTVHEDEVGQLRIFWRAAVALRDAGYVERANVLFQAQAELLYAIPEQLSDKPFEEQLDAMEEYWDSEVPRLGEPDASGWATWDAYRHEQTLRPTRVAEAAPDTSDPYSKWAAAEGLADRTQAMSLRSTDEDEDADPYAVVLFSDIRPLLLCLRSSCSKDVFRSVWLAFLGVHVPGFIQSLSEHPEDNSDDRWAYSHLATEPYLASLFPPTTSVRRITADAHAGVLIGREREFGSGFGPVKNWGYDVIGPLETHGLAKWTMWSARDAQGVDLTLMREIFRHCRLKQGGSDWDVLAVAFEAAVDVKSAVKLSKSLLAGAPESLPHWATHARLETLRGKLKDARKVYQTVLTSGQNRPGESPLWWDWARMEWLAGNDDTALQVIIQASRVAGSGATAVLRTKRHLVDLLAQTFDLHWKEREAWIKVAALLELLTSSVQSALSLFDTYLSGVQARSSAHESLTVASLTLLYNHATVLKNPTPPALLRERAENAIDMYPNNTAILGMFLEAEKGQGIWGRVRAVLGETAVDGMGKEKGIARRVAEVWVAGWEKGHWEAEVERTRRGLAAAVEDERTRGSPVLWKVFIAFEMRAGEPERAKKLLFRAVGECPLVKELYLLAFGPLREVFSTRELRLLGETMAERRIRMRVGLDEAVGAWTDNVNRAREETGESDSRSGDEDEIEESARELRRLMPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD47</accession>
    <name>A0A2G8SD47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD47"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="551" mass="58655" checksum="2CAA211E21F0ADF4" modified="2018-01-31" version="1">MSSSSNSKKGKATNPQHEIESARERIRNMRHFEPEDNAEVEDHVEWVENMTLAMVRRGVASAGAPDGEVEAIADDVYLQHAAQLSHLFDNWPEWASPILTGAHERAQAAAAARRVADAEAERERKQAERNARLDAFLVKNKIPRLEGSPSGTADRPATPAIAQPPVAASSATGASSKSGAKRKRDPKSPATTGAKPKKPKEEKEKKDNGPKLATITDPKRMIGVAVCEPLVKGKRCDKCVSDKKGCVHGEEPFGEWYRSLEPVPGERGGLTPFASVGRLTDRLVATPGPIAGPSGTSGTPIAPRSSTARADPETPTPSRTRRALSVELGAPMLNFEPHFPTNPTPEPIASGSGGKTAEEDSGRTANDATGPAEVGSGDRLQAEATKLLASYVREGPANFGHAVHELGTDSLRQEGIRADGRRAIRAVRNEIAFAKARIAVFQGVVLGLEQYEADLVERLRREAREAAESAANADDTNEGAGDNENANDGTGEGMEASGSVGGNEPTNTSEPANATATGSPAGEEEGAGESARKRKGKEKEKEKRKRRRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDL8</accession>
    <name>A0A2G8SDL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDL8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDL8"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="236"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="557" mass="63748" checksum="441A4E852303C493" modified="2018-01-31" version="1">MGENWFQREFLQPKRLTFNVIFYGLHLFFFAYGWHSQATNKKLSVLNGLTWSVWTSRGAGLVLAFDGGLILIPMLRNVIRVVRPRMTWLFPADENIWFHRQVAYSMAFWAMVHTTAHYVNFFNVERTQVRPNIALQIHYNQAGGITGHFMLLIMVLMYTTAHHKVRHQCFEAFWYTHHLAFFFMIGLYSHATGCFVRDSALPAYTAVFPFYTTDHCLGYESWRFIIWPGIIYFGERIWREIRARRATRLSKVLVHPSGAMELRIIKPSFKYVPGQWLFIQVPEISSFEWHPFTITSAPEDPYVSVHIRQVGDWTYALGERVGAGPQVVAAMTKAALKGDEKDDHIYGTRGDFVEIDSTGRALPAVRIDGPYGAPTEDVFNVEVAVLVGAGIGVTPFASILKHIWYRQKKGTLKSLKRVEFFWVCRDAPSFGWFQTLLQEVEAAQADPNFLRINIYLTQKISEDMLWNIAVNDAGAEYDPLTLLRTRTMFGRPDWKSIFGRMSQAIQTSQYLPGSNSQLKTTVGTYFCGPGALAKAIKEATLEATCSTVNFTFAKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDZ0</accession>
    <name>A0A2G8SDZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDZ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDZ0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708297" description="Transporter" evidence="2">
        <location>
            <begin position="19"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="17366" checksum="7CA5A101A77580FF" modified="2018-01-31" version="1">MRYSQFLVLLLLPFLAVAQTTSTPPTSRQSTQSGSTQASNSGSGGSTQPTASGSSAASASPSVTVITSVFTTVVLGTNRVLSTITSTNLITSTIAPSGQSGSSGASGSKSTSTSSTPPPTTAPASIDGGGNLSGGAPSPGATGAGGVFGPNDGYIAAAFTHQASMLLTVLVGVAAGGALVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE76</accession>
    <name>A0A2G8SE76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE76"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE76"/>
    <dbReference type="OrthoDB" id="3357813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="721" mass="78170" checksum="A9F61D92CECAC0EB" modified="2018-01-31" version="1">MPTDLPPTYTQEPSETDAQASDDSDSFVSAHDGAPPDVHPEAAPADADAGEALGAEGGSLQILIIPVAEGYVHFQKGYLGADGERAAIEGELQIKSADTEFRWRKVSVSLRSVERAPEREIELAYTELVLADAPDPSPQQRSSFPFSIPLPPDTPQCLHTSRSSLAYSLTATVWPVEEAAPLRRSLIVHTRRYTSHTHHLQPVPETRIISEPSRVEVQLPRTMFKAGEPIPIYITVPTPPADLVVEQGQRLRNLRAELVRVININRSAAEEDELNESDFEDNLPPEGGQLSSQTQKTAPGPSTSRTPPVLVMRRGEHGERKVVTFSGASCRLHPSRALRIRLVLHQPNESTRPDSSLHHPPSEDTLSTDLDAQCAYITQSTVLHSVSFRLLVHATFIRMSSHTETVSTVSIPLLILPPSAPLPEVESSVDSAYMKKHDRPPTRTVRAEDAEVPQYEAGPSAIPGAPPPFEEREAPPPFWSAAAEASTSTHPPSFLEADASSSRLPTFLESEREIYVPSAEYSSIVPSPAMAPTELAFEGEGSLFGFSTADQFDGYADVVPQRSFTPPPSVEMATHDADVTGLANMDLGQPAAIEALGLALEQQNITLNAHEGSSVSVGVDERFLPPPPPPMDDPSDPPPSIDSAEFRAPGAAHDSPPRAQSPPAHVHTHAIISPPPHDEGESHGHAPPPYRVPGMDHDHGHDDHERVTNPPPYMDLVHENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEM9</accession>
    <name>A0A2G8SEM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEM9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEM9"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="2">
        <location>
            <begin position="71"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="574" mass="62497" checksum="58724E3DA8F72396" modified="2018-01-31" version="1">MPPSSLSVAVAAASLALGAYYTGHLHVRFGVPIVEDESERFSCRPFLPSLFAETPPTTGHSALGAAAETADRFFTERFSKGDIDSLSIAVVTSGGVLFEKNWGVTRGNESATSPPTTSHSQYRIASVSKLFTALEGLILEERGVLSWADPVDKYFEDFQYRLDGLDPQHPVQPRETTPMTLRQLVTHTSGLGRDWPPGTVTEWPESLFGGGPPPTNGHPFPSHQALFDAIAKHHLTSPPGSYPAYSNTGTGLLGIVLAAADSKAKGVSPAITYAELLQRDVFGPMGLNGSHFLTTEQNKDLVVVPSLGPEVADQDFLDAMNPAGGQFSSLSDLIIVVQTLLNTNHLKSQISRYSRDKWLQTVHAFEEDDWTEIGFIWEIIKLKDSNGRARKIYWKLGAMAGYHSAVAIHPGTGYGVVVLLAGHYPDAAKLTYDAFEIFQPAIDRALADFSTELYAGTWTDAESGVEKKSSARIVIDKGTLYIEEFTLEGTNALAKFGAHGRLALRSSMRRDELRVDTGLPGYNGKKHMGCYPYWNGQDIWGVRNGAAINAIYFTGSGEERRLHVPALSLVLKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFA0</accession>
    <name>A0A2G8SFA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFA0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="181" mass="20821" checksum="3ADE21A1B0ECA5D2" modified="2018-01-31" version="1">MFSLRSVDIDGPYALTYPQPPRRALLSSSSRLVSDFPRLASPPPSASPSTSPISSSPSRYYDYPISHPSTIPPSIPPVNPDTLGLGISFDDDSDLQARLWALEQQDDPALLQLQYDDSESDSEDTDYDFYADFDFDFDYRYYCHVTEDDNGWRSRFGRRVRKLFSFPVRLVRGRRFWAWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGB6</accession>
    <name>A0A2G8SGB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGB6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGB6"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="351" mass="39378" checksum="4733EF358004368B" modified="2018-01-31" version="1">MSQSVAQPENMAGPSASNSIPPQLSAEQDSQPDRGSLEDVIQPDNGLDMLGLPLLQYPPPSAAGDEGNDSQQVPFEESSEGTGVPPLAVLSELRDAQKFIEAIRAATLDKDALDEDVLERLYAPPSTLLDSEINDPTFRFALDLFLDTNTSSDDTYKSVRSSYHRHHPDRLLPSHYQMKKRLTEITGIAPIKHDMCIQSSRSDGQDKVPRRVFYTLPLGPQLQAQWRNPVGAQNMRHRETRTKKVIEELRRDGWNVSEYDDFFQGSDYLQAVLDGKIKDGDTVLMLSMDGAQLYRNKQSDCWMYIWVILNLAPDLRYKVNIQEGSVSGMQKGIYLSFHSSSSRSSRLMVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGE1</accession>
    <name>A0A2G8SGE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase CHL1</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ATP-dependent DNA helicase chl1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Chromosome loss protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">DNA 5'-3' helicase CHL1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSI_04884</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGE1"/>
    <dbReference type="OrthoDB" id="267079at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001372">
        <property type="entry name" value="ATP-dependent DNA helicase chl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="23">
        <location>
            <begin position="8"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="121"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="224"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="22">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PIL32767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="883" mass="96698" checksum="E54EE57D1373B6A4" modified="2018-01-31" version="1">MSLKLPTPDNFVAFPFKPYDIQLDLMRHVFSAIEDKKVAIMESPTGTGKTLSLLCASLTWLKDEQHRARTGQLEPDGESAHGPDWVLAQTIERRRRQLEADDLEYAERLATARKREAQLRKLSRGHVRKKPRLEPELDATPDDGDDEAAFLPDSDEGDDEKSNISPAVLALMRKLQGPTSSPDSEKEPTCTKIYYASRTHSQLAQVLHELEKLNIKLNVAVPSAPSSSAAARSKPPDSDRGCHGKRPAEQNSGEGDGEDSEGTGPRVVSLGSRKQLCINEQLRGKVGDLDEACRQMLGEKGKNRCPHLPPADEETRMLDLRDQILATPKDIEELSSIGQAADTCPYFGSRRAIPQAQLVLLPYNLLLQKTAREALGIDLTGQVVVIDEAHNLISTLLSLSTTRLPLRTLAAARHQLAIYLARFRTRLSTTHALHLRRLANVLDALAKFAEEWREAQARPNPGAEKRQGQGQGQGKGAGVEVGEEGGGVNLLEIEKYLRESKIARKISGYSVKELEKAAGQDTIKLAKLARLSNTTPPLHAVESFIVALTASSDDGRVSFSLVDGSVEIKYQHLNPATYFQEVVDTARSVILAGGTMSPMSDVVNQLFASLPPERLATFSCGHIIPASNLQTLMLKKGPRGGELTFKFQQRGDDSLIAELGQILVNFTNVVPAGMVVFVPSYGFLNVITEKWKASGVLEKLGAKKKVFAEPQESNEVEAVLRDYAAAIKDNQQTTADGVKKRGALLFAVVGAKLSEGLNFTDDLARAVVIVGLPFANLGSPELRERMRYVNRLQQQTQAKAAGAKDAGTELYENMCMNAVNQSIGRAIRHRADWAALVLVDGRYASPRIRGKLPKWIEAGTVVTEGFGQAMKELGRFYREKRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHC0</accession>
    <name>A0A2G8SHC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHC0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="101" mass="10667" checksum="9C8EE9ED652322A8" modified="2018-01-31" version="1">MAPRDSRQAPAARKLFQWSSPEEWKAGIGGRTGAWAVEQPQCDSPHLENWVDPDASTSGPESSCSGCGGVQGKYNIAKSSTTTKKSGDFKIMYADGSGATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHL6</accession>
    <name>A0A2G8SHL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHL6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHL6"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="38590" checksum="C51F3842F837CCBA" modified="2018-01-31" version="1">MSTTTKMPYVRLGNSGLKVSKIILGCMSYGDPRWQEWVLPEEEAIKQIKYAYDHGITTFDTANIYSHGQSEIILGNAIKKLNLPRDELVILTKVYFPIAKEGARLDGNPEDSGIINQHGLNRKHIFDSVKASLKRLQLDCIDVLQCHRFDYTTPIEETMQALHDVVQAGYVRYIGMSSCHAYQFHQMQNYAITHNLTPFISMQNHYSLIYREEEREMFPTLKLFGVGSIPWSPLGRGLLTRPVGADAETTRGKSDSFLMRLENDVVPAVRTSVEELAKKKGVSMAQISMAWVLAKPHVAAPIVGTTSLANLEDILASLNVKLTEEEIKSLEEKYRPLPISGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHV9</accession>
    <name>A0A2G8SHV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHV9"/>
    <dbReference type="OrthoDB" id="2367075at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35641" checksum="2C8A44905E55064C" modified="2018-01-31" version="1">MTALKMNSEATSTTAASPVPSSPAPERFQATSPKSPRRDDEFYCQDIVFLVEDVLFKVPRRPFEHESEVFSGMFALPPVNSPYGVEGSSDDNPIQLEGVTEDEFKALLWVMFRSISLFLLYLSSPCYSRLPSSSALPPTHRTPHTPRRATPVSPIPSGYGSSRTLTQPQWVSVLRLSTMWFFKDIRTRAIAELSKLVATPAARIVLARTYNISGWTEPALCALAQQDAPLSAQDLEALGWDAAAKLVQIRESVVFAGACVCGCNYCTVAHGHIATATPGAGAAGVGVHGHGLGLAAQQSAGPRAGQVTVASLRKKTDFSQQIRALFGTALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIG7</accession>
    <name>A0A2G8SIG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04186</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIG7"/>
    <dbReference type="OrthoDB" id="2499931at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="52"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="425" mass="47665" checksum="FA33226FE92796E9" modified="2018-01-31" version="1">MASHPQPDGAPSIGLRTPQDLWRYVDRFSANLPARPVNLVKRPPGQTDVVLITGTTGGFGCDALEHLLRDETVQLVYAFNRKDSHALERQRKQFAARGLDSSLLDTSKFRMVEAVLHEPGFGIDAEVLEEIRTSVTHIILNAWTVNFNRPITSFEEDIQGVRNSMDLALSSPFTNAPAVIFVGSITVFCNWKMAGPVPEIPIDDPASSFGMGYAESKWVSERILQNVALERGAHTVVVRVGQIEGDRMGHWNEREWFPSLVKSALFQKCLPKQDKTVAWVPSYEAARALVEMRHSLDPIIHLVHPRPVPWDTIMVPIARELNVPLVPYTAWLSALEGSIASERGSTKEVQAMRLNRALRLLPLFKDHCKKMERMPERDAIGFVFLGMDKAMRVSKSLASLPQLDGERAMLWLAAWRKSGFLSLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SII3</accession>
    <name>A0A2G8SII3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SII3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SII3"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="256" mass="29231" checksum="33BA0E304B024106" modified="2018-01-31" version="1">MSSTKNPIGSGPLPPILKVPLLITNAILIFRSFTPPEKPPLARERKRVEPAPGITLSRYPSVEKVRRGFKVASMIFFCGISLIEAALILWYHSSWIYLAYVPRSMLPFVRLGSLGLSPGALAGCLLTVVGGLLRTRSYRELGRLFTYELSIRDNHKLITMGPYSIVRHPSYLGVFILMVGNITLLTSKGSWFVESGLWDTYWGRRIGCSAAGFFLFTALRLFLRVDEEDRMMRKEFGEEWERWAKKTRYRLIPFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJE9</accession>
    <name>A0A2G8SJE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJE9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJE9"/>
    <dbReference type="OrthoDB" id="2754335at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="266" mass="31059" checksum="B20438BCFDD7FCB5" modified="2018-01-31" version="1">MPEPALPIPRPQAAADDSAPTPDYAFLLRDGPQMPHPRRDPKCERCTDPDIKPWSFNPAKKSYRRGDILQIQESVHTPIDALFTSVKKTLPGTAQSASSVRSYLNSDRKPRPGVAMESRPTTTMTNEQTYTCLMATYRGIYAFAHLPPVLKHFCVPISPHYEIEKDGTHLHTSPEWQRPHAWLIACACVSMKLVVGRWEWKDETETRRPEFSFRFYKKMFKDLDQIRAQKWDEWWQRAQEKGYLEARYMEYQAFKRQIKEANEQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJI6</accession>
    <name>A0A2G8SJI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJI6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJI6"/>
    <dbReference type="OrthoDB" id="2802356at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="415" mass="41175" checksum="C2203B5035780576" modified="2018-01-31" version="1">MAYEYYRNSMPGWGTSQDVLSYNSIMSASRPPGVGVGSSALSLGRDDAQYWHRRIYSGLAPLAQVLPTDIGAAAAYEAYWTWKHNSFLYEPLSADRVQQREGLVGMAIVEDAHASLPSTALLSTRLGQYAGRSADTFGLRAAAEAATAVASLLTDRLIGYIGAGSVPSYASSASSYGAGPGGSPYTYGGYRGRRSSFAGTTPLGAPGGSPFIGGGGASPYLAPGLGAGTGAGAYSPRVSTPRSISPLPPALGPGVSAGTGPGMGIGGAGAYGGGMGLPGSGLGGGMGGGTGMGMGAGMGAGMGAYGDPSMSMQSVPPGSTIIVKHWGRRRRHSDAGSLRRRRSPSVEVVQTGGGAPYAGGYAGGGYSGGYGGGYGRGYGGGYGSGMNVYSAGMGVGASYGGRGIYGPPAYGGRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJR3</accession>
    <name>A0A2G8SJR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03675</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJR3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJR3"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="358"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="867"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL33967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122358" checksum="6CD0DF69F483B5E2" modified="2018-01-31" version="1">MSSSDATDAQVIFIPKSTPNITDGRVMPAVANTFEHGCVVHFKDKDVPPDRQVAKATANITNALISDWYIAHHEEFDAMTFEEFMAEFRDQWLPRGWAMKLRAQILQASQSHQEPFDLFCIRVMKLNTQLRGSNLRFDDDGLRATISANLYPDLAVQANEYAITSIVSFKDWQDAVNELDIARRRINAQVLSLLATNSKTATKQKASNPFVGIKDALKLKLPKLMDLKYTYLRAVKGCFKCRKDVNAAHTSANCPNGYPDAATYSTCIPKGWKPGPSDKENKKLAAHSVNALNAAEGSEDTNVITAIETLAVSTGVLGSGSDSETFVLKDANMVIARHQYDCPKKWRDTWKTLLEQHLAAGRLHPSDSPYASPAFLVPKTDPAALPRWVNDYRVLNANTVPDMYPLPRISDILADCAKGTIWGKIDMTNAYFQMRVHPDDIKYTAVTTPFGLYKWTVMPQGCHNAPSTHQRRMYNALHPFLGKFCHVYLDNIVIWSQSLDEHRRNVEAVLQALCEASLFCSDKKTDLFLTELHFLGHIVSSAGIQADPSKVEKILNWPVPRNARAVRAFLGLVRYVANFLPNLADHTVLLTPLTTKEAEASFPEWTSAHQHAFDAIKQLVVSRECLTVIDHDDLERNKIFVSCDASDLRTGALLSFGPSLDQARPVAFDSAQLKGAELNYPVHEKELLAIGEDNVAADALSRIDVAALPVEPSAVTIASTLLNVTTVLAACAVDLATESAPHSNSIRFSLHTDPAWLGAIRAGYAKDKFCLCLRLLVGTLGVRELDGLLYIGDRLVIPRVPHLREGIFHCAHDALGHFGFEKSYANLRDAYYWPRMWKELEMLYIPSCEECQQNKSLTRKPTGPLHPLPVPDARASSIAIDFVGPLPEDEGFNCLATIMDRLGSDYHLVPCRMDTTAEQFAVLFFDHWFCENGLPMEIVLDRDKLFTSRLWDALHKLTGIKLKLSTAFHPQTDGASERTNKTVTQALRYHVSRSQRGWVRALPRVRFAIMNTVNASTGFSPFQLHLGRSPRLIPPIVDQPLPASHPDAEVAELAKSIIDALQLDVMEARDNLLASKLAQAAAANVHRVVLQGPVRSRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK13</accession>
    <name>A0A2G8SK13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK13"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK13"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF66">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="38299" checksum="2CD8EC4CB43D5F77" modified="2018-01-31" version="1">MSPSAEVNGQSLNGSNEPRVNGANGTSKVSRPLTAGIWAPIPTFFFSETEDIDVPTFTAHILRLAKAGVRPLLAGSMGEAHHLSHSERVILIKAARQALDEAGLVSVPIVAGTGAGSTRETIQLCKEAAEAGADYTIVIVSGYFAGVLANNRKALKAFWTEVAAKSPIPVVIYNYPGACGGIDLDSDLITELATECPNLCGVKLTCGNVGKLTRITSTVSETSFAEQHPRQNPDAPFLVLGGFIDFVLPTTYVNAHGAITGLANVTPYAIQKLFELSAAAAKDPSLLPEAQRLQGIVARADFTIAKASIAGTKALLEKLYGYGGLTRRPLPPIEPEAVVALWEHPHTQDIVRVERELSGKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKY8</accession>
    <name>A0A2G8SKY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-chaperonin molecular chaperone ATPase</fullName>
            <ecNumber evidence="3">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_03939</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKY8"/>
    <dbReference type="OrthoDB" id="2738154at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013869958" description="non-chaperonin molecular chaperone ATPase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL34228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="667" mass="73504" checksum="55F3599018897DB7" modified="2018-01-31" version="1">MSRPTRKQSRRIVSSLSIIFLAFLAIILLCPVSAKAHAGTDNKLKENIIGIDLGTTYSCVGVKRGDQVEIVANDQGHRITPSWVGFSDDERLIGDSAKNAFHSNPQNTVFDAKRLIGRKFDDPELQKDMKHWPFKVASRDGKPTIQVKHQGDLREFTPEEISAMVLSKMKETAESFLGEKVTKAVVTVPAYFNDAQRQATKDAGTIAGLQVVRIINEPTAAALAYGLDKTEGESQIIVYDLGGGTFDVSLLSIEDGVFEVLATAGDTHLGGEDFDNCVIDYLVKLYKRKTGTDVSGDLRAMGKLKRETEKAKRTLSSQQAAHIEIEAFEGGNDFSETLTRAKFEELNMDLFRRTMKPVERVLRDAKVKKEDIDEIVLVGGSTRIPRVQQLLKEYFGKEPSKGINPDEAVAYGAAVQGAILAGDGDYCTLGLVDVNSLTLGIETTGGVMTPVIPRNTVIPTRKTQTFSTAADNQQSVLIRVYQGERPLTKDNHPLETFELGGIPPAPRGVPQIEVTFEIDSNGIMKISAADKATGKSESITISDGKNRLKNDDIDRMIKDAEKFATQDAELRKHIGKINELSTYVWQLNSQVADSDGLGGKLRDDDKKTLQEELTRFSTWLEESSKSVTLEEIEERFAELQSVVNPITSALYQRNDGSGEDIFKHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL78</accession>
    <name>A0A2G8SL78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL78"/>
    <dbReference type="STRING" id="1077348.A0A2G8SL78"/>
    <dbReference type="OrthoDB" id="2799983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="126" mass="13854" checksum="DF643B0B929F42A7" modified="2018-01-31" version="1">MVNSTLTIATDCQVGVSSILCGGFVTDFASYLKPYPQPAAYAEGSPAVALVRNILVRSTAENQKKHGFGDPVKGVQKMWELSKLENPPLRLLLGKNINTHAKQYLAQLTKEVDEYESWSDHLGFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM24</accession>
    <name>A0A2G8SM24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM24"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM24"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19503">
        <property type="entry name" value="RecA-like_CDC48_NLV2_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001985">
        <property type="entry name" value="Chromosome 9, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="339"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="612"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="784" mass="84718" checksum="63AF016F2DEFB741" modified="2018-01-31" version="1">MAAFVGRKFTVDVSNPAEPISRASRRLIINSELLKQAKLYSGDVVAISSPESPKMISNASLNQLIEFLITDRNLPSASLGPRPMYHRTVGTHVPVPHEHRMGTFPDEITVLNSDFVLPAILVSAPLLLTAKVSQGAKVSLFALGSSKSPPGAPSLRHAELAQVIRVKEVFCEAGSQASSSRVPSKSTDHRKGNRRDWLTLQVREALIDLEYLTPTQTFDLKYEGRSRRFAISSVSTIHEDDQQPDIADDIQSLSLSDSPPKLWTVGWETTVSLETESSNAEEARQSGSKEESSGAVERGVEQDAYSAVGGLDKQIAQIRDLIEIPLTRPELFRQFGLKPPRGILLHGPPGTGKTHLARAIAASTGSAVLIVNGPELSSAYHGETEARIRDVFAEARAHPSCIVVLDEVDALCPRREDGPGGEVEKRVVAQLLTLMDGMDDGSGNGKDGALGRVVVVATTNRPNAIDPALRRPGRFDREIEIGIPDADARFSILTVLLSKAPHAISEEGLRSVAAKAHGYVGADLSAVVREAGTLAIKRWLASQSHQSQPQSQSPLSCDTTPQLALADLLAALPAVRPSALRSLFLDTVPVRYADIGGQARTIQKLRECVEWPLLHPEAKTLLVRACATESGVNFLAVKGPELLNKFVGESERAVREIFRKARGAAPSIVFFDEIDALATSRSGSDSGGGAHEGVLTSLLNEMDGVQELVGVTIVAATNRPDVIDSALMRPGRLDRILYVGPPDLEGRIEILRIRTQKMSVEAGLDLEQIARLVRRSSLFPFRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM80</accession>
    <name>A0A2G8SM80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM80"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM80"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="162"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="409" mass="43046" checksum="2D63597BEF772470" modified="2018-01-31" version="1">MSTNISTQPRIAIIGAGLGGLALLLTLHRRGIPATVYERDTSFDARAHLGGSLDLGWKSGQRALRENALQDAFDKHSRPEGEEMKICDSTGNVHLKLGGEGEDGPGGPPQGKEDIRPEIDRTVLRKLLLDAVPADLVQWNHALSSVRALGDGQHELAFANGTITTCDLLVGADGAHSRVRPLLSPAIPQFLGVNGAEISLAPAATKLPALAETIANVGQGTMMAMEDSRMLGAQVNGDGRIRTYAFLRAPESWTLPADPSSAKAVLKEEFAGWAGWLLNLIDYCDESAIYPRALWSLPVRHKWAHVPGVTLLGDAAHLMSPFAGAGANLALLDGLELGLALASLKEKGTLGEVGAVSEAVKGFEENMCAMAGRVAAKANRTLEVCVGPGTPQAAIKRFGEVAASGEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM88</accession>
    <name>A0A2G8SM88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM88"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM88"/>
    <dbReference type="OrthoDB" id="2755983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="325" mass="36353" checksum="BB637AA3F0A9571C" modified="2018-01-31" version="1">MSVVSKLPFIPFTASNYADLQRNVYHSDRDSYRGELRHGLNGRLAETTGISDIQVPYSKERYARMLVWCLHVLLDGWPWHIPFMNLSDIKGGAAPLRLLIDLLRDGMLRFIPAPEHVWKRALHDPDSVLPHVIAAAKLPLLPRTTQLPKFSLDRFSDLTTPRGGRAPFSRNQPPAAQAASRRLPALAEERVLHPHNLELVLTAPIGPGSSHTTGPRRQRCNTNKARHRPVSNPEGKPLRARKIGVLTSQFVLDRPSGPGTSTVPVSPSKVMKPLSEHRLPLLINDDLGRYVVLGRDESGVEEIDSKSDLEDEREGSQQAKRRRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMQ0</accession>
    <name>A0A2G8SMQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMQ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMQ0"/>
    <dbReference type="OrthoDB" id="3220866at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="162" mass="17756" checksum="432BDB15E6122A1C" modified="2018-01-31" version="1">MHRISVVCTRDYTDPDFSSLAFPEMRLLIGLANGLSVPCDVAITAGLSYYLNSRRTGFKRVCQAGLAIVFIAFPGHLFHLPFDLLIGKLYCNTLLATLNAQKVIRMDGENVMEANTLILNLGRVNMPTMCHRPDGLRTPSARTGDSTPTASSLKRMVGTPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN51</accession>
    <name>A0A2G8SN51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_02986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN51"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN51"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="TesA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF194">
        <property type="entry name" value="FI04476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase TesA-like" evidence="5">
        <location>
            <begin position="132"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="396" mass="44360" checksum="7C11CE27E310E4A5" modified="2018-01-31" version="1">MTSTTDSPRRKTLLEKLHAFAYFSSGIYALFIALLATPFFQRHAFYQHAIRLPWGARFDLPEKYGLAPGKTMNFQLTTTDNLTLGSWFVLSEPFYQSHRMSSPLPVANPSLEVVHDAIRKHPTVLYCHGNTATRAAPARVQHYLSFTSRLHANVMVIDYRGFGESQGQPSDWGLKEDARAAWRWLVEHGAKPEDVLIVGHSLGTGVVTTLATWLTQEGVKPRGVVLLAPFTNVASLLETYDIQGYPILQPLQTFPLGRKLLKRLVQHEFDTLNAIQDINVPVLIAHSQDDPDIPYHHSRTLLDKLLAPHLPVAPLLPPNPDMTFTQEQYAAVIEGEKARRAKRSELVRKVDIPSFGTIEEFDGSAGKVVYVETFWGQHNKVGLQEGVQDVIAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNW6</accession>
    <name>A0A2G8SNW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNW6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNW6"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF2">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="359" mass="40323" checksum="7A96EB6DD07F9C82" modified="2018-01-31" version="1">MSEHPKYDTKGMPFRLLGSSGLRVPLFSLGGWLTLGGSVKGDPVKEIIKTAWDNGINMIDCAESYSGGENEISVGRVIKELNFRRTDLIVTTKLFWGTRRGPNDMGLSRKHIIEGTKESLERLGLEYVDVIFAHRSDHTVPMEEVVRAFNFVIEKGWALYWATSEWSAQEIEEAHHIATRLNLIAPIAEQCEHHLLHRERPEREYAPLYRKYNLGTTVFSALAGGLLTGKYNDGIPEGSRLHTEQDPMFKRKITFLESPEGQAQIAIVRKLSEFAEKELGCTATQLALAWVARNPNTSTVILGATKPEQLLENLKALELVHKLTPEVLTKIDEIVGNKPAPWPTYGRPALDIFAKLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP39</accession>
    <name>A0A2G8SP39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP39"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP39"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="3">
        <location>
            <begin position="230"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="354" mass="38499" checksum="0F434433EA78DDC8" modified="2018-01-31" version="1">MHVLYECYDSRDDYAAQRRVKGDKGSGYTPMDSVADVDDDELPGLDEVPYDHTEDTLTMILDEGALGKRTAKSRVEMEKITLLLGAQRHGVPACLSGNTSGQSSSFVPSGSTTHWKELIQAQKKRVLDERRAGAERGDEGAGEHIGGQQEPNAGSVFVVTYAMLESLRNRQTDIAGGPQDSNLLLLHGVIEQFTLNEEQLNAFFLAAKHLHHHEPDPLRMIIAGMAGTDRNESHRFVVLGPTGSSAALIGGSTYHSILGFTLSSDTGPFASNSHDKVRSRLELVDMLFIDEFSMISCLSVFHIHKQLASAFSTSLEAFGGKSIVLAGDPAQLPPPGRSPALYSSKVEYAARHMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPF9</accession>
    <name>A0A2G8SPF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPF9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPF9"/>
    <dbReference type="OrthoDB" id="2758859at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="949"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1179" mass="123803" checksum="047FDA68BB885982" modified="2018-01-31" version="1">MSLAAFLPLRSPHPHHRSPPDAFSPRMSFSPRPALMPMSRIRIETVSRRTNDLPRDPSDWVDKDLLSYVRYNYSPIEAVSLSEVIERDRLTPTALWYLQAEPEQLLAIAEEESLRDTLLGLALSLKPAVSPTSPRIRHVRRLSEDLERPPPPPPPPPPSPPTPEEPELEEDDDVAESVVSDWALDEDLGGNDGTTPTMVDLGDLAGSAGQPEPPLEGLGLHTGEPQLDNTTAPPPQPLPVDTDDLINLEDDAQPTVPPEEATNPHTTRADTDHSPAEEPASSQDASANAHVPDAAEEKPPVATPSADPSPPLDEASASQEAGAGVPADPFAGSPIEDDDLGNPWADSEDTTKPDPAPPPHPVDPARTATPTSDYHDANSIHSDEGERPEATPAEHEPEPSPVHAQQQEGAAMSRDEEQLSTETRPPAEAPIKGDPGSGDDAPPSEEVQQEETPPPTSEEIPIEPPPATDPVQTIPPDANPVQTTPPATGPAQTSPSVTDATQRSPSVPEPVPTRAEETARTQDEHVSPAADPEHHETAHLDQENSKDVHAEVPPAQSTTVTSGIPPSDQSQETASAESGESAHLGDEVRKVGEEAITQMGEETGDKESEGRDATVPAITTTESPEATVSLEASQDSLDNSPPLEGSSEGVVSGVRANAQSSTSETTQAVQPEAEVTSLTTQEETLEKCSTPLEKESSSPLADTTIDPTPAVTVIDPPPSPTVRLASGIEAQLIGLDPESTEQTPSASPGDTPPNESLTMSESRQASPPAETEALVETKAEKPLSPPLGCIPSSASHASSAEGKSPTPPRLNTAFGSLSEPSRFGRPSAGARTDNSAWQQSPASRSTLSPATAKTIGWGSAHSPAAKPPAWGRVLNSVTSFFAPPSESSTRESSQERETPDPRSPVSPAPAVRQSPWAKGKNWSAVASSSPSSLQESKSKQPPAPITELSVSVSPAQVSPPTHTGSDTKASVLPLALPFDSSLAEGFVIPESNPRTEDLTDVMSDSVLVDSGMPSAGNGEPVRDADASQDLPVQAVVSSQGDLPDVGDVGGKNEIKDTEDEDLVEVTADDAAGAEKEGGPESQPQGDVDVDEDEDENTPLNLRLDRVRQMTGDSMSSAATSDTETQGDEERPGGRRGPKLQTSGLASEPDGIGSPSVESPIVGTPTQSKARKRKNKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPM4</accession>
    <name>A0A2G8SPM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPM4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPM4"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="13"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="406" mass="44861" checksum="78A0C733945A6448" modified="2018-01-31" version="1">MTAPPPPIPKHLIRSHTSQVNVVCFSDDNERIYSGDFDGTVVVTSTRSLRAIATWKAHTDGLLGIQEWAEQEQIITHGRDNKLHVWRTVKEPARILGGSASLPGLQAPELCYSMDVNALNYCRFSLLPFPEDALTDERRALIAVPNLMESAHADVWTLPEKQRLHAAIGKAGQEPTLSDGRDVRNPVGIIMSMHLSTMPHPHTAGRTRLRLMCGYENGSVTMRERTGDGETSIEGLGWDVLWSVRLHVESVMAMIVSRDGVFALSVSADHIVGRYNLAEAEKPELLASACTVHRTKHPGNGSVSIRDDGRVCAVGGWDGKVRLYSTKTFKSLGSLAYHKKNCQSVAFAHLRSDMRSSGTATDTEGSEEEDEDDMSEAEKEERTRWLVSGGQDSRVVVWSLMDFDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPX0</accession>
    <name>A0A2G8SPX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPX0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPX0"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="570" mass="61084" checksum="2F1F40BCC17F4743" modified="2018-01-31" version="1">MDSLLAIGVGLGLRALIDSVTHHNHRVNGSLVGLWEGAVLRHFITKYPSTFDPYIAYGFRLLADLLWTQSWMRLVIVVLWTFMGMLLSDVGVDLSADRRFRRLTRTLRYTVIYPLLRQFSSSRRSSSSSSTGPSHAQYYQVPGTTSTTSTARSPATQARSPTDVSAPPRSATPGPRRPALRVPGSFSDRTSETDTDATRPPPISRENSSTSQRDGSVTSRSSSSRTPSVTFSDPLVSQTRPLTRADTLRRTPSNTVHPSITSVLSPPSSVGSPPATVIRPPISRVPRPILTTAPAVPTPPPVRPRSPELEYVSVPAIPEPTYPLRPVLSDDERSLRSGLTTPRSDRSRPDANLYSPPPVNSGLTTPDRSYANLPHSATPVPYGTSSASSTATGGTEATAAPLPIRIQEPEADAEQVQASLLHPGLLPDIPTPQPSPGVVQPAEYLPSPSPEDKKAPLPIRMPEPDLSATLGAGAGVGSGGVGGGEGNRMTMSEPPPAYEQTPGQEEMDSGSNTPAQSVLSHSGDRQRLLQRAESFRSTADEVDKRRARLKRELEEARRGRGSLGGVQAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ01</accession>
    <name>A0A2G8SQ01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ01"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ01"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013600740" evidence="6">
        <location>
            <begin position="24"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="195"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL35849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="508" mass="53082" checksum="4680F8F2F5B2A373" modified="2018-01-31" version="1">MLSLVVFRFVTLLFLLPALPSCSTPVRHGGASFHVAIAPRSFKDTLSGTQAIGNASTFDPTPAMREGNALVFKYAKANQFLSGIDLNPDTHPEAGYPKFEPPATPSQGANSASQSRPSTLPSLLSPSPSSSPSSSSSSSPSSSSSSSSSSSPGLVHALMSPDDEAPNIIGMPPMAPGTVQMPLTDYISGAMDVLYYGPLDFGSPPQSLTVDIDTGSADLWMPVDCQGCANDQFSSRHSSTYRGSSTRCAITYDAGGQGSGKVSGTLATDTVGIGPATVRGQAFCAVRKESSDLNDEPNSGLLGMAFGSIAATGRPTFFESLLAQKQLAQSIFSVHLTRTRETGSQVCFGCYDATKAVGPVRWNPVISRTYWTIALDGLSVNNSQSVSANLIAAVDTGTTLIYMPSDLADNFYALIPGSASAMQYGAVPCDTTMSVALILRGETFTIHPGDFNLGRTDADSNDCVGGILALGHGFPPNLAIIGDEFLKSWYSVFDYSGRVGFARSVNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ77</accession>
    <name>A0A2G8SQ77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ77"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ77"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="46108" checksum="B8252FB05E459273" modified="2018-01-31" version="1">MEFLNGFPPATLKDVTVQLRGWLCRLAQGASTSWKRLCLGFLNPKSRASSTACATAEIRSGLNSSDSAFALLQRGAFTLTPTTGGYHSYRNFVAGSKLTTYLVISGEGHDDMVRELVASPDGKWVATGSKDSTVILWDTADGTIAQRWIAHSYKPVRALAFSPDGQHLVTCGDDPNVKVWDLGPRADAAQGTPELVAALGGHTYPAPCCTWSPRGDMIASASMDHTIRLWDAHTFRQLHALEHPLHGMNAIALVAFSPDGRWLLSGMPIHRYHVWDAASVALHKSFAAPPDGGGDDEAAYSFPAAAFDRAHASRLALVSEPSSNLVQILDVEAGEELAVLEGSDKMHVWDIAFSPDGTRVVTASLDDKAPISNPCRLTIWDASTGVALFSLRGNERRVSQALFSPCGQYVASASLDSTTKNEWNKHPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQG9</accession>
    <name>A0A2G8SQG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQG9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQG9"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="205" mass="22463" checksum="2656C14D70A2F6F4" modified="2018-01-31" version="1">MSQGPLPVLPSLIVWPGISETVVVVIKPPKGLNSTDNSVFSGFLEIVNADESHVTYLGLAAALKDTHVVDNTDIFFGVQIPAIFDANSNVVNTTKNFTFQGTDFPSIVSRLNFDTPLLRRFDLVKPDIKLTTSLSRRDGVHVFERWNYTFPATYQTRGSNQNAGTDFNEIALSSQLQFANGTAIANGSYCTVRLRALNVTGDPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR47</accession>
    <name>A0A2G8SR47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR47"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR47"/>
    <dbReference type="OrthoDB" id="3013446at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1088" mass="117437" checksum="BA01CE4D936B3875" modified="2018-01-31" version="1">MATAVHLPSPETAGIPLSDVPTALVSPGAHTHSNSYSLKRLTLTDLDLRDDRYPSLSSVKSSPPSARSQFTRLDPAIDAGMTVALRASYEKEHGPGTTPPQKSWLGENITQEPAYWESSQDVSLAPVLEAQPGLPTARESARPAGNSPVEPNPADEQATSGPSAVSPADHASSIAVPLAQTVDMGQQLSKMRRSDDQYEVTVNSIPPPNASLSLPPGVGPATPILSPGGASSPRHPSVPGAGNGTNANAASIPPIVPLSAGPTYNPSTMQIPISPKPRAYAQHPTYITPPAAPAMQPSFSPPQVPKEEVCVECAMRDQDMADVDVTSPGVWDRESDVLYEELCRREMEEETSGVSLSTDSTSRPRAKGGKLTEENLRFWLSINPKEPSSRQQTLDLYVKAQRSLLEADALARARALRESRLLDEKMRDTFSQLRRSAYELGSSSSPADDSFGLRIKTPRVPSSAQTQLHSREVTLLENGMIVEHVDLRKEEREERDRKRREERREKRDVSRPRKSSRSSRSAADVASVYSVPLASPVPQADSGFFSNPRDSRYSQFFSPRPSSVLAIGGERPLTMLRAQSQASFSEVQSIGSAASPRRSRFFGFKNLSSAWHSRDSVAPTGSMIDMHVALQQEQQYFAAHPSAVDISSNTPTLRVSQSWPRTVTSPEPAATAAPTSTKKKSGLKKIWKLVTGTSKGSTKGAGQSRSIDRHEDDAPLAPPPPLSYLVDREGAGRRHVSTPSLLSSISPNQFSQWASSPPTAPSSALPSPTSSRYPTLVPELNSELKDQPIPEMVVPDHRISAFELGSSSDGTPNDLDIRGRVVPSSSRTLSSLGPPTPGATTPSNRPQSAVIMRRDKSLPPLPGESRVEFPSNPMPETRPQTMYDLLQAPSNLTTRGLPPPQAAFRTPEARRQSFGGLASMPHPAVQTLPARTGYARGPVNVPPFLAEEKYAEFGASSPALSQWGAPDATKRSLTTPGKPKQRRSRFGLASLFGKKSVELERPESQVDIGGLSNGSGSMEPLDYNPYRSSASDQRDEPSWNGAAGPGSSHSSAPRMSVMSKNIAELVEQDPEFVAYRYPSSDQRLEVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR63</accession>
    <name>A0A2G8SR63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR63"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR63"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013890081" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="10">
        <location>
            <begin position="73"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="11">
        <location>
            <begin position="208"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL36271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="47325" checksum="5101ADBFC0EE0302" modified="2018-01-31" version="1">MRSVLPLLALGLSSLVVAKDGGGHGKDDTGNDAYYGSTSSTSSATTSTATGTTVSGAASSSNSTSSATKGTVCETYMCITGVVNGSATTYTMQSTGKANLGWMAMGFGQTMANSPMVIMWSNSNGSITLSQRQSSSEVMPTVVSSPPRVATLDTSGSDLTGSTPKFSFTIETSGGTSQSIIWAFGTTNPDDASVSANLVQHIDSGPTTIDMSTPASSSDTSDPVSDPNASSGNNDTPLQPYQKMIVAHAILCTVGFLILLPGGALLARYTRTFTNAWFGGHWVFQFALAGPVITAGVILGIDTVAKEGQPQLADFHKRLGIALWILFYVQCVLGYVIHRWKPASFAVTKKRPVQNYGHAVFGLLIIGLAFAEVRSGFHDEWPAFSGRPPISNAANIVWYVWVVLIPVLYFAGLALLPKQFGQERPGKKTQSDCAQDGYTDEPRYSDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRJ9</accession>
    <name>A0A2G8SRJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRJ9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="184" mass="20876" checksum="966A6E98F6FE2732" modified="2018-01-31" version="1">MRPWAKPQKRKQKSDNTAWKSRRERGCDCPLEPQETDTPRSKKRSRKRRTFVVPTWKVTVPLRYHGPQLARPSDAPTDIGATSVFIMGSRQENSLVLASTLPGYASHLCLRVLWWGRPRLSPAAAKFPEAPRTRHSPNTATKRRARFAPQAMSSSPRPSPARSALFTCSLVAARTEIRFSRLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRR6</accession>
    <name>A0A2G8SRR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRR6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="201" mass="22207" checksum="96B07F2C9892830F" modified="2018-01-31" version="1">MWEEIRAWEKLQRIGDDNGDDNDDGTVVEAPTAAGAVCGGFVVGGEGYPSYFVPDVDGPGDSEATTDSTDGDGDNEDYDDRLWPDTYSIDSDSDIDYILDGFVVIDMSDATRSVFWNHRRRCRRKRRGALVGRLGDASGGMATYHELSQSVVGSGNSRYRDMDMALRGLGQGHRRTWTREDWDSCIVYVVSVPGLDPDSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS38</accession>
    <name>A0A2G8SS38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS38"/>
    <dbReference type="OrthoDB" id="3002933at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="163" mass="18011" checksum="6C4686875D3FFA97" modified="2018-01-31" version="1">MPEPGPAIPASFNPGSLYIAGFTQARAPHVGLILPVDAQSGDLVHIRIDRSISPNWMYQHRAQKIEGDMFLSSLLKIHDVPAGAITVEDLQKAASVVPAPQNDTFGECSRWLYMVIQELDRLKLVVLKDVVALEEEFSTFASDNRAYARRDRFPNVAVSPHCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS41</accession>
    <name>A0A2G8SS41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS41"/>
    <dbReference type="OrthoDB" id="2762949at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="276" mass="30282" checksum="768A437E91E3AFF0" modified="2018-01-31" version="1">MLLSPDTSSLSLATSPAILSPNSASPQVDESAELRSHIEAPISESLSNTTQSSDSDSESASSISTSSIPSLVTVLSYTQAHVESDDDGQEHVSLGDWQDSNESSEDEYLASAPLAQRTPGDPLPPRPTRVHIRFYYTFPEFYPAGLRHSVEMEEKFLLHVYSATGASGEVVDLPLVLATHQARSPAVWNTYWANIVNSQLYAELKPEQREFLHGATKILQFYATPSPQAMETWDEFSRMLCTAGLLQFRYPHISGDVLLAVLIEWAHAGIPDAFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU43</accession>
    <name>A0A2G8SU43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00973</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU43"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU43"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL37280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="247" mass="27023" checksum="40EBE9B38E310B21" modified="2018-01-31" version="1">MTSIGTGYDLSASTYSPDGRIFQVEYANKAVENSGTAIGLRVKDGVVLAVEKLIHSKLLVPAANRRIQTIDKHIGLASAGYLADGRHISNRARDEASSFRENYRAPATLQYVVDRVGLYVQAYTLYSSVRPFGCSTILGAVDKTGPALFVVEPSGVSYGYRGAAVGKGRQLAKTELEKLKFSELTMKEAVTEAARIIYLVHDDAKEKDFELEMSWVGDETNGIHQPVPKDLSDEASRKAKEALENFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUE9</accession>
    <name>A0A2G8SUE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUE9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUE9"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46395:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="140"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="47754" checksum="1DB4E182213649A5" modified="2018-01-31" version="1">MDQTLARKTLQELIKREDLQNKKCIDCGNPNPQWASLSFAVFLCLQCAGVHRGFGVHVSTRYIHPTHNLAHSFVRSVSMDTWQEEQVKRMQMGGNAPFREFMKSYDSQSGGYKEGMNPYDTYHSWAASQYKDKLDAALAGRNFSPSAPPEGFGSPSNSTSPPNRPSSAQGLRKSRASARSSTGRSLRSESPASFTNSPSPSPNPGGSMTGSYDQKAQNEAFFASLGHANASRPADLPPSQGGRYQGFGNTPTPPPGASHPSFALSSANAPSLVDLQENPVAALSKGWSLFSAAVVGASRAVSENVIQPGMEKVMDPTFQASVRGYAAEAGKRAGDVGRSANMWGRTTFGVDVAESVNGVVGVARDRMGGGPQSRGYGALGADPGHEESSALYHDDDDEFFDSFNGSSAEQSQPMPSKLSSNSTQTSTATRRAPAKKDDEWDDWKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLI8</accession>
    <name>A0A2G8RLI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLI8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="83" mass="9326" checksum="6F1917331F03CBF7" modified="2018-01-31" version="1">MYNYVTERFAGYEELCRTGMTFVTYRSNPGQQTVICGTYSSGLAQKEDCTASNGPKHMIWTLTDLLITCKHDPVTQDPSKNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLR7</accession>
    <name>A0A2G8RLR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLR7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLR7"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="59010" checksum="0C42D2320DA69374" modified="2018-01-31" version="1">MARPSPACKDGTAGDPQRQPRTLILCFDGTANQYDGDNTNVVKFYSLLKKDDESNQQLCYYQPGVGTYFNPGVVSPLFQWCAKILDEAFACYLDAHVRGGYQFIMQNYICGDKICMFGFSRGAYTARALAGMLHKIRLLPRDNPEQIPFAYKLYKSTDANNTALAAGFKQTFCRDVQIEFVGVWETIASVGVIMSPSLPFTTANTTIKTFRHALSLDEHRVKFQPNLYHWGDAERGSGNKSSDKTKISVSLSDSPARAKEKLNGRPNARTRSLRSFLSRWPPKQPQNRAPASLSMSQKAAEVDLEAVVATKSGVSASSDNAESSSSMSSGLGDQIDGGTDVLEVWFAGCHSDIGGGSVSDSTKLSLSEVTLCWMVREVVLAKAPIAFDPVAIQRANLPGSIFEEAEAKTVEDVNLPGQLDPSTSNPNKTQDPGPQAPTGPTEGGGGDPLDVAVDALQPLHDQLKIDPAWWLLEIIPLTHTVRDTNGRTQTKWWIHLGRGRDLPNKPKFHVTVKERMEDADLKYTPRAKWTAGTEIYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMK9</accession>
    <name>A0A2G8RMK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_15448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RMK9"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="535"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1099"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1825"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1898"/>
            <end position="1940"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="67"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="490"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="876"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1340"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1485"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1607"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1825"/>
            <end position="1837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1856"/>
            <end position="1884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL22755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1940" mass="215977" checksum="ACE0C5D2017A66E3" modified="2018-01-31" version="1">MKTRRKSKITPAASQEEAEPPAAGSSAPFTVTIPDDLDLDYLSSLLPEVVDLTNPSPETISSLYRLLVGQAADAETSQRELEEAQAEIQRKDVELDQALQDRETATSELQSTTEAVQKELEQVKQEKETLATERAKLQAQLDAVSTTQTSSSAEVQTLKQRVEETEREKRDLMGVVSRLQDDAAQRENEIQALRADLRQARQDHQALERNLRELTSSETSTKFKLESLTQQLELAKTEAERTSAELVAKSEEFAKYRKTKHVELAELQAAHDSITQAHASTESSHKALQSAHTTQTHQLTEALTRIQTLKGQLAEQEATYSSEAAGLRRLVSMMEEREKQAKVIVDSIEKDYEGVTDKAERREAVLREEIESQKQRAEDAEKRVEDLQAVLDRMDRGEFPIPAFAGSISNPGTPARGMSASTPARNGSPSADLLTSGMLGLSPTVAMASRAQRGGKSFTEVYSDYIKLQEEFSRKCAEYDHMDRTLSAVLAQIEERAPILTQQRAEYERLQAESTQLASQLSQTLSERDALATAAEENGQKLQKSLRENELLEKQLGDLSRQLRTLLKELGRHQDPSLPSDEELEHDAMSRPAENIEAVITNNLVLFRSIPQLQEQNQKLLKIVRELGSKLESEEKEYKEALEREQGEAVREAHEAIKQLQSQLESQKRSSEVTVQAYMKERDSLRTLLQRQQESGSGTRMLNGINGQSQTSEPSELAKELEEVQKQFEAYRTEMGVDSTRLRDETVTAQREVSKLTTSLAKANAQIEVLTERHRMVQDQIIIQKRENDDLLTRNQKLFDQYTRMDIEVNRMSEDLLTSNQFLEQLRNECANLRAEKKIWESIQARLVEENKILAVERSHLSDLMANVQKMHNDLERSGENDRRRLESQLQLLENQAQDMRAQLSQERESVRRITLQKDLEIREQQGKIEKATQELGRTRESLVAAETSKTHLEERVEQLTRQLQGNEEKLSVYERRASGINGITSRADEDLSREQQLEAEVAELRSALKVAEVDLATARSHVQQFQDISQANEAALATLNATHDEYKAETEAELERRQSEIQALQEKLRLAEERLNEVTQQNAELQRSFDSERAAWVNEKKELEGTILDMTTSVQHTQSDKSAWEAEIRQLEVRAKAAEDRYSREVVAHAEALKSLQDLKKRLSQSQTAARENRAAAETAQAKLASSEASWQQQRGALDNEIADLKTRCKDLGEQNSILHQHLESVSTHAARIKQAASSTSAEAGEVESTDDDTKLTELRSLVTYLRKEKEIIELQLELGKQENTRLKTQVDHLSQNLDETRQALSEERERAAQAAVSEEQHSQLAEKINQVAILRESNATLRSDCDKYTKRARRLEAELREVTAQLEPTKEQVRIAQAEVEAKDEQIKMLENESRRWQERNAQLLSKYDRIDPAEVQSLKDEIAQLQTQNLELKAAAEQQAIDTAAQQLKLRQLEEMNTKLKHTGQENNSRAKARFNKDALEITKLKQESTELQERVDALTKELEEVKTHSQEAAAAGASVDPALTQELEALRADKASLEKALAEERAALMVNSAQTTGLNESLEKLRAEHESLLAEKATWASTAPSAEVPVDVAAAQSQWQSERAELVKARDEAKALADTLNQQIAKANDEIRSGRLASEKFQSRIQEISKIRIAEGEELKRLRDELQKVSQQAETSTTSPESVAKHAEELRALEERLVQKHEAELKAAFEAAKASAPAPPPDTQAAIDAALTAYKETLKEEHTKALDDAVERGRKEAAARAKLKDQQLVRSQARVKELEARIQQLDPTAATAAPAVAKEAAPAKAAPTAPAVATTSTAPVSGAPAAAATGKAGLPVNLPARPTPVPRAPLRGRGGPPGATGRGGHAIRGAAAGLGRGAGGAAAAVAAVTGDAASNVAKRTREDGVDDDTAAKRQKQGEGAPVPPVALRRNRVPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMW5</accession>
    <name>A0A2G8RMW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMW5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMW5"/>
    <dbReference type="OrthoDB" id="3190888at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="147" mass="16177" checksum="8322D14716CE22E1" modified="2018-01-31" version="1">MVYSINSGLVTSVIGVICVVAFAAMPTNFVWLSFFWIMGKCYVNSFLALLNSREMLRERVAKGAWHLSNMATPPSIQPSTSASELHSKIRTKSLRPDAGIAVSVETITEYGPRFPHRDDMSAIKEDEVHQLTIKDDTASTAEAIGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN12</accession>
    <name>A0A2G8RN12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA polymerase Rpb1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN12"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN12"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="242" mass="27746" checksum="11641374A485F2C8" modified="2018-01-31" version="1">MDGAFIERQNIETFGLNNMQFEHDFRVDVTDPSGGFLPGVLQAGLDDSSIDLQGKLDEEFAQLSDDRRLLRNWIFPRTDPGAPRYLPVNLQRIVQNAMQIFHIDRRKPSDLEPAYIIDSVRDLCDRLVVVRGESLLSKEAQQNATLLFHMLLRATFATHHVLERYDLNHEAFDWVLGEVEAKFNLSGQAHPRDSVTLATTSGLTVRPWRHATTQKPEHLQCSTYARSVHRQYFPQTNGAHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPT9</accession>
    <name>A0A2G8RPT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_14834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPT9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPT9"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="170"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="262" mass="29925" checksum="4E7644381007F347" modified="2018-01-31" version="1">MLKVLLLGSAGSGKSTVLKQLRLAHGVPFSPQEIEFYRQHIFLNLTQGLKRVVDAMKDMGLEVSPENLDLVPILNDAKDVQDNKPYPAEYRDVLKRLWEDPNVQAAYARGNEAALPDYLQYFYADLDRFFKPSYVPTEKDIVHSYVPTTGISETHLTRLSRRGYDLLVVDVGGQNSEREKWIDCFENVACVVFVVNLSGYDQRLSEDKSTNQMMDTMTIWDSISQSHLFRWTPVVSSAPSLDRASSFQHQEKPPIIFDAIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQA1</accession>
    <name>A0A2G8RQA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQA1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQA1"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="98"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="137"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="246" mass="27206" checksum="39E9EFE881EE0149" modified="2018-01-31" version="1">MPAIVDKIAHALHLGSQTSSDSATTQSASTTSSAFDHNKVTVFFVLGGPGAGKGTQCANLVKDFGFCHLSAGDLLRAEQHREGSEYGDMIRKYIREGQIVPMEVTVKLLENAMRAALSENRQGEGWQDGKGRFLIDGFPRKMDQALKFDEDVCLSSKVLFFTTTEEEMLKRLLERGKTSGREDDNEESIRKRFRVYKEQTMPVIEHYSKEGKVATIDATATVDEVHEKAKLIVGRVFAGEVGNITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQC5</accession>
    <name>A0A2G8RQC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_13450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQC5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQC5"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="148"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL23701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="332" mass="34458" checksum="8F1F2C2A5D338C78" modified="2018-01-31" version="1">MVKAVVLGAAGGIGQPLSLLLKNNPSVTELSLYDIVNTPGVAADLSHISTPAKVVGYLPPDDGLKKALTGADIVVIPAGVPRKPGMTRDDLFKINAGIVRDLATGIATTAPKAFVLVISNPVNSTVPIVVEVFKKHGVFDPKRIFGVTTLDVVRASTFVAEVHGDLGKAPTVVVPVIGGHSGIVPLLSQSSHPLPSGFAQESLEALTYRIQFGGDEVVKAKDGAGSATLSMAYAGVEFTNKIIRAVKGEKGIVAPSFVHLSADKNGGEALKKEIGRDLDYFSAPIELGPEGVVAIKSLGKVTDYEAGLIKTAVPELAINIEKGVSFIDSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQZ3</accession>
    <name>A0A2G8RQZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQZ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQZ3"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="68675" checksum="8A87630A626FA45B" modified="2018-01-31" version="1">MPPPHQPPPNPVSPYARASHVLRPHHILLLYIFALGFQPLDENLLPGPFMLALHRIMIREVAEITPPRSYKQILTDIKQAALPRADGPARAFILRLEEVPDAFTSPDALSDFMQTLPLLFHDRDDEETARFVIPSPDLTCQNGMIKCIANRLLIDLGYGIADYQLFKTKLDKTDYAEAETYALFMKGLVTGDSNVANDGLRRFFEQKFHEGSESLLHRLPPLEPGGRPIINEVQPDMHPLEILADVKKLMNVHHQQPLALAYERIVQAIGLYDHYIDVQGGQFVESEQLAQHAVQSVLWNNFGCTKLARIEEDIVIAFSEVGGDDNTRLTVTLNRAYHVARQGKYQAAVASLLDPDVWRGLSLADYNLWAFEIWSILALRACRRRQQRQLKDYLIPKRPNGPHTAREYSWGRDPMGCTIRDPLYDAMLNRMCEQSHASVDQLLTALWHAEYHGRYNLYRTAIILLADAGLEFGLTKWCKRLVDEVMPQIMSENDLEQKAFAEYTLARCIIAAGEATQSALEEAVPYLEDAAQCYCILEMYSAQCDVLFLLSVVLHNAGELERRDEVAREHAEALEMRARVHTVVMESWIEDTWAIVEGVGAALASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRC7</accession>
    <name>A0A2G8RRC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13804</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRC7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRC7"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="193"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL24053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="413" mass="46700" checksum="3D796575BF182316" modified="2018-01-31" version="1">MDEIGVDIQKEEPTFETVVEEKTALLQELESEEDLYIKYKKLARHLEMLDIQESYIKDEQANLKRELIRAQEEVKRIQSVPLVIGQFLEPIDQHTGIVGSTTGSNYVVRILSTLDRELLKPSSSVALHRHSNALVDILPPEADSSIAMLGKEERPDVTYQDIGGMDSQKQEIREAVELPLTHFDLYKKIGIDPPRGVLLYGPPGTGKTMLVKAVAHHTTASFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQGSNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPSRREKRLIFQTVTGKMNLGPDVDLEDYVSRPERLSSAEIAAIVQAAGLQAVRKNRYVVLPVDFEEAWKQNVKRADETLDFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRY4</accession>
    <name>A0A2G8RRY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRY4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRY4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45570:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013795671" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="56"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="557" mass="58583" checksum="5CCF65EA40CBCC2B" modified="2018-01-31" version="1">MFGLQSLVFALLLASWVAAAPAHVAMPAYSLKSELCRLSPIIQKVLCPRQSSGNTNSVTTPIGTALGTSDDSGATRFAVKYASASRWQQSTLATTWELPNGSSDVTALPVPCVQTDNNGNTTGAEDCLSMILYVPASLPADAPTFMWIHGGSFTSGSATGPGLDGSKLATATQSVVAVIQYRLGALGFLQPSGGFNLAVKDVINALAFLQEVLPSFGASASKITVAGQSAGANMVRAILAAPSASSMFQSAVLQSDPMDFGFLTPSVHQEVLGNFTMNLNCSTTNTTCLNALSLDSIMSAQTSLVNAAANNELDPAAGASEPIRPVRDDSLITNPLDLTASFPQQSKSIIVSTVRNEAALTIYGNFPTSVDSSLYEQLVQFTFGNPRTTRILNTAVYAVSPAVNGVEADQRPQLEELGTDQIWRCASWTFARNWVGSGGAAYVGEYMLGATYPGNEEVPFCTAGGSVCHQDDIEIIFGTVQNATTAQSALITEMQARYKNFLYTGSPNADGYSTWEVAGTSDANAINLGATGLATVGACNTSYWGDFVEYDYQVFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSJ0</accession>
    <name>A0A2G8RSJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14061</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSJ0"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="330"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="405" mass="42820" checksum="37AAEDD0194C0F3F" modified="2018-01-31" version="1">MQEYLSRQLYAATYAYIYAFLVKQEHKKAADILKRAVKDVVVLKDGVEAKGPSLERIIKEWKELTEKAAKGAADNSDSDSDSDDSESSSEESSSSSDSSDPDSSDTSDDSDSSDSDSSDSDSDSDSSSSSSSSSSSSSGSKTKVEYKAAKATPAKAVASKAPVKAKVPPPKVAKAKAPSPETSTKTLSTDDAETSESSSSDSDSSDEEDEEKGPRAKVAEKKAKESDSSDSSSSDSSSDSDSDSDSSSDSDSDSDSDESAKAAAKKRKKPAKEEVSVTKKRRTDEEGTSVATAVVSNSITPSGSTTPKPSGNGKGNGDGHGKKPRKSNTPFQRIKVDQITFADERLRDNRFDARGAGEADYGARASRDLIVTRGAGFRKEKNKKKRGSYKGGEITMQSFSIKFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RST2</accession>
    <name>A0A2G8RST2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RST2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RST2"/>
    <dbReference type="OrthoDB" id="2754125at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="316" mass="35949" checksum="6ECAB115C2FD7C0F" modified="2018-01-31" version="1">MLVVFSSNLPGIVLREIGLPPTEFEDFGELTRIILDVIEAHREAWDEAGVLHRAVSVGNILIDPVTRSGYLIDWDESCLRSEIENGPVEPYRVGTWQFYSALTLSYPRKPYRLSDDVESFVHVFRWLVLRFHSTEIRNLRTFVDAEYESNVRSAISGIRVGGDQKLRSFSTPTSLFKVTRNDSLQGLLEQLAYNCFLHYQLIDMDLMHARYSVPHYTNPQAAQQPKPKPDHAPIPTPPRPSDDDRIKGIIAEIFDLDHDDAWSESPWQAAPPGTDACDVVGFLSDHAGLVNIFKQAVDNNTPRQADQFHLRFCEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU44</accession>
    <name>A0A2G8RU44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12923</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU44"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU44"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553533" evidence="4">
        <location>
            <begin position="30"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="356" mass="37613" checksum="EBAA790ED69EF354" modified="2018-01-31" version="1">MQAVKTSLTRLLGIRVPIVCAAMANGANAQTACHIQVEVTRGGGFGFVGAGFSTPESLRQDFDFIRSSFPDRGNKPLPVGYGFIGWLLDKNEDSAKQLLDITIENNVQAIWLAFGTDIHRWIQHVRTSSANARAHHKPLIFVQVTSVEEALVAANEWKVDAIVAQGTESGGHGGASAPSTFTLVSEILAALPQDGAAPAPPILAAGGMATGAQVAAYLSLGAAGAVLGTRFLLTPESAYKPAQRAALLAARGPGATVRTMALDTARASFGWPPNIDGRGLNNKIVDDIEAGVDHATIQARCKAATEAGDSSYMVVWAGQGVSLMNEIKPVKDVMVELHTDLVRQLQKSRRLLQEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU55</accession>
    <name>A0A2G8RU55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">squalene synthase</fullName>
            <ecNumber evidence="3">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_12755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU55"/>
    <dbReference type="SMR" id="A0A2G8RU55"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU55"/>
    <dbReference type="OrthoDB" id="431150at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000023">
        <property type="entry name" value="Squalene synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL24868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="494" mass="57067" checksum="A1B3EE6E855F3A2D" modified="2018-01-31" version="1">MGATSMLTLLLTHPFEFRTLIQYKVWHEPKRDITQVSEHPTSGWDRPTMRRCWEFLDQTSRSFSGVIKELEGDLARVVCLFYLVLRGLDTIEDDMTLPDEQKQPLLRQFHKLAVKPGWTFDECGPKEKDRQLLVEWTNVSEELNRLDASYRDIIIDITEKMQTGMADYAHKAATTKSIYIETVDEYNLYCHYVAGLVGEGLTRFWAASGKEAEWLGDQLELTNAMGLMLQKTNIIRDFREDAEERRFFWPREIWGRDAYGKAVGRATGFREMRELYQAGNEKQALWVQSGMVVDVLGHATDSLDYLRLLTKQSIFCFCAIPQTMAMATLSLCFMNYDMFHNHIKIRRAEAASLIMKSTNPRDVAYIFRDYARKIHARAVPDDPSFLRLSVACSKIEQWCERHYPSFVRIQQVSGGVAFDPHDARTKVIEAAQARDRELAREKRMAELREKTGKLERKPAEETSPVEMMLYVGGAFVVVIAITLGFAWILIRYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUL8</accession>
    <name>A0A2G8RUL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-reducing end beta-L-arabinofuranosidase-like GH127 middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13063</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUL8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUL8"/>
    <dbReference type="OrthoDB" id="5358475at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654717" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="2">
        <location>
            <begin position="433"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="663" mass="73162" checksum="F597E60BE3726C7D" modified="2018-01-31" version="1">MRLPEVEDTVNGPFTMIWSLLLSLFASLTARSVVNGQTPAGLAPKAFLSLPLGTVKPAGWLYDQLVVQTNGLAGHEHDFYHYVSESDWIGGTSYYSSLEEAGSYWFNGMVPNGILLDDPTIQSQVQQFLDYVLDHQDSTGWLGPEVNTTKPRYLWGRYPFFFGAIQMVEANATLTDRVVTAFHKFVALANTMLHNGEGLEDWTRTRWEDFVIVLQWLYDFHPEGNEDLLIDTMKQLKYTGDPWEDVFNETYFPKTAVEDLRNPFPVLTWHGVNMAEGLKALPSTYRFTHNQSDIDAASKGWDLLFQYHGRPSGIYAADEYLAGLEAARGGSYLYQVIGDPKFADRVERITYNALPATLTGDMWSRQYLQQQNQIAAKNMTPNPFPEDGPYSNVFGLEPNYPCCTVNHPQGWPKFISNSFVTTPDQASLVQVYLGPYTVSTMLAATGNKVSVSVDTLYPFSDTLTTTIKATKAFTYYVRIPSWVTNGTISVNGGPSRPVSPTNGLHAVSVHAGTTEFTLDLPSEITIEERPHGSVAVHRGPLHYAFDISRSSRVLAQNAQQPLAVDLEFDATEAWQYAIDPSTLTFHTGTPAGGQLPSPIFDSGLPPFTISVAACPIDWAEGGNTFAAAPPTDPACTGAVTNITLSPFGSTKLRIGEFPTFKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUX8</accession>
    <name>A0A2G8RUX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUX8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUX8"/>
    <dbReference type="OrthoDB" id="10260285at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="168" mass="18887" checksum="1DDEF2AAC39FCC29" modified="2018-01-31" version="1">MHHLIDGDHFLVYCFTKEDEASLELKQGRAARDPGDAPDGDEPTYFHFVEQEMLTQFLLVFDEGTDVRVRALPPKGVYYENIERKMLLKKKHVNDVVKLMHTPMSKEVQQEHKETLARVTDPLFPLVRADADADADGEVDDGAFGLNGASAETANAIRQEAIDVFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV91</accession>
    <name>A0A2G8RV91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV91"/>
    <dbReference type="OrthoDB" id="2744819at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="327" mass="36332" checksum="1C264B2578FFE97D" modified="2018-01-31" version="1">MDYATSALPAQFDRRAATASFIVNLFTFHSKHGTSPDLTAPRVFMDLPAPPEHIDRDMVDECHRIARAVATTVENKYVLEWSAEDYAKDVGGGVLVKPEHEATLMRKYPPLIDVHKVLNSMEEHLPIIDDRPAVITDRDGNVLVWSLPGILPEKRQMEILKATRCIEAQLSTKPVPPDEPIMKHWRSGKPFFSKSGDWLSGTTLLYVAGFAQGHTGPKHPLIPSADAKSQRAKDWMAEFETSGGVLDGILAITHPGLYDAARAVAETIWQKRGTSHSLMELWPTCFSSIQVIANRGTPRHRDNSALPGWLDLLLSLRTYGENGVLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVD5</accession>
    <name>A0A2G8RVD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_13362</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVD5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVD5"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="102"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="23837" checksum="84319F0476350373" modified="2018-01-31" version="1">MAPASTYRSRSAEPSGSSSGISRQASESSESKNLLVLIPDRIDVEEEARFYDDIVDSASTVGQDDYPYGQPDTPPRTSIEGRSIFSNDIWLGDNCGESNAFARAVDIPGWSSVGDKRGGAYVVYDCAIKTKEGTVIHALKRYSAFAQLQARLRATLPSTQQPFIPSLPPKFPLAKFRPTFLDRRRRLLQHWLCAILLHPEIGGCQAVREWVMDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW46</accession>
    <name>A0A2G8RW46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW46"/>
    <dbReference type="OrthoDB" id="426133at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052762">
        <property type="entry name" value="PCW_deacetylase/CE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834:SF2">
        <property type="entry name" value="ESTERASE, SGNH HYDROLASE-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37834">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G00620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="456" mass="49877" checksum="355D6FFAE8C15203" modified="2018-01-31" version="1">MSQSPSVEHPTVEMRLQPFALPRVILASVILVLHAGAAPSIQELQDAPVISVDNPLVHFHGRWDASPGTWWAGSGFKLHIQDLTSLTLNLGPHTTSPLASIGVSVNYEPFYTVNVSQGSNVIPLHGSSGSTSTISTLTGSSESGPEAGPKTMTNKTIVRVNVESWQNNRINLETIVLNRGAKLLPYVPSKLAFQFIGDSLSAGQYLPQGVDQAWPFLTGEFFGAEHNVNAQPGAALIRERLILFLKDIVSYGNEHGISYQYFKVAVSQSRILNLLGTEDTGYFYTTDHNYTTPWNFLRDHPEPTHVVVHIGANDASQNVTADAFVQTFQTFLGRLRGLYPAAPLFVFTPWGWPSADGSISYYYDGQYERIVRDRLRANIAHPNAPSNSLPFHILIPIGVRIYSPPFLPFSRTPGADPGVPTPEVPMETEPTRGATDSADLDGPTFGGWWEHCGCKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW72</accession>
    <name>A0A2G8RW72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW72"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW72"/>
    <dbReference type="OrthoDB" id="2763255at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="360" mass="40849" checksum="458CEB697B47DCA6" modified="2018-01-31" version="1">MPRLVVARHPQAKAVTAAVAAEKRAIGTRSEDRKEHLRQVRAVFAEFLGAPEDEDFVSGHTPAPREVVEAYLNGTGLGPDRNDLCFTDLKPYNNAWNCAVASELGAILFTRQRTGKWRRPDGTRVTVASQPYWADAALEKFKRQAADWRDAMGRVVTDTTGVRRQESRAETNTRRLQQGEEHSKVARQRERRAKRWDRRLAICQGAINFATTTFDQNQWKKFLQIIDTLGKEGMSSDDSAEEEATHRSCYRVSILPWRRDFDAIMDKIDAERWNPRSGYSTRGSRPTPRHRQDKALVSLEGPDDIHVSRREAVSGLPASFYDAQWLKGRSNDYINRVLCVSEEAADWVVEIANLYGTSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWQ5</accession>
    <name>A0A2G8RWQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_11703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWQ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWQ5"/>
    <dbReference type="OrthoDB" id="2751170at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="852"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="975" mass="109487" checksum="E36116EEB2F1ABFB" modified="2018-01-31" version="1">MATGTRSKTKRGQGDQSASERLRATDSDVEEKHLKKQTKKAEQKGKAKRKDMPSELDSDSDSGTSSSEEEELGVDEAASNDERASRRAGTGARKDVPKKVKKRKRKAEGKAKSGMVEEGGDVNEGTGARDNVIEKKEMTQDLRIIFIDVTTRKVKVNGRRRPMLGHWCTICQWERLTTAETISDDPKVIKSKGKSEAGWYKGGNSSDCRHIASAHYELYSQKCKELGLEEQKEAVPKDIWAAWEAKNEAAEGKKGAQTMLDTVVKMVKRPQEFTPEALLQSITVLIVTGNHAMALANEVAFRNVLITMRPTTRSSELPIRSLVRTKITNEFVDFLNGLRDNISCAPGAVSIAWDSWTAPHISDPFLDMLALWIQVNDGVWSMRDEVGVFHKIFGSHTGVNLSRYLLLFLDRIAVTLKSHNKLGHMTNDNASNNGTGAEVIAARLARQGVLGTWNKTEAQLGCLRHIIQLGIEDFMGVVTKKAAAETKQAIWDYDPRLEENSVMHGVLDVIAVILTLAVKASDHSSSPSFLSMHWSGHWSPVVRCSSRSLGFHGITRPGPGCQTNSPVERELCRILPASRAHTIQASGTHKQEFQRLQLANLADGQTKALVIPLHNNMHWGSALKMLSWMHYLQVPVNLFVESADHLFGPITKVRHQGEATVSIPWHAFEIKSEGWKRVALCIKILTVIPVLETLCSKWEKRLEDPDFEIFHDAIRLGLEKLNKYYKRLNNTDAYILAMLLHPYYKLNYIEEQWGGAEEYTADLEAGDPHARDCQKYARDVVDKAVHNNAFMTLYWPKRLGQVPGKGNQQVDKPVAGPSKSNSLLSDDEDNYDRARWERLQKSQSADGWKTKLVQYLTNPCLDVSKYEDTVNWWQRHATVYPTLARIALDILPIAAASVGVESLFSRAKHVATDHRASLDPDIFEQIECLHYYWKRNMVDFAQLNEEDSEEIDVAEFADLESQEELLAEMSDDDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWV7</accession>
    <name>A0A2G8RWV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWV7"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="358" mass="39745" checksum="E6979E795636D04C" modified="2018-01-31" version="1">MLETTNFTLPGVNDHPKFACSFVRWRPLQGENGPAAPDLDSAPSKAPRLRLSLVFFHCNGTHKETWFPAVEHLFEALHASPGLGFTVIEAWAIDSPQHGHAARLNDGVLLELPDGLDMDQWNAPINTLLRSGLIAGHRIVGIGHSAGSVSLITMTLGHALDRLPFSSMIVIEPPMMPPKLLKHAQEKRLPMLRAIELAKTRQDVWSSREEAREWFGRQFPWRRWDKRVFDLFIEHALLDLPTATYPDHHGVTLACTRVQDSAAYTKFKIGFAALDRLTELCAALPVHCIFGDTIDMVPEALHKVIVDEKAGRRMKSVRNVTGAGHLTVQDNPRGVALEIRDILMGDYGSEAGATTCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXV1</accession>
    <name>A0A2G8RXV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_12102</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXV1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXV1"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="18">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="165"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL26346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="49166" checksum="6437E614253C21F4" modified="2018-01-31" version="1">MPGEIPHAPSPSVHRPKPLTAEQRKLITAIVPVLEQHGKTITTLMYNQMLEENPALKNVFSKSKQERGQQPEVLARSLYAYASHIEDLGPIMPFVERIAHKHASVHVEPAHYDVVAKYLTNAIIQVVGADVLAGALYDAWIAAYWNLAYVFIDREHALYKEAGWVGWRDFVVAKKVQESDEVTSFYFRPKDGKALPPYRPGQYISVQRFVPQIGVTQNRHVLPLTHVRSLARYSLSDAPTPDHYRISVKREPGLPSPSSDTAGLAHPGTMSNILHGTLNEGDTVELAYPFGEFFLDASAAPVVLLSAGVGVTPLLAMLNTLVQPQAESSSPKRAVSWVQAVRSSRLHPFREHVASVAKAHPEQVTAAIFYSDADEADARGKDFVVRGRLDVKELDAKVLKLDDPTTQYYVCGPDGFMADVFKGLKARGVDASRLHAEVFGAGEEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXX4</accession>
    <name>A0A2G8RXX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXX4"/>
    <dbReference type="OrthoDB" id="3191045at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="323" mass="35643" checksum="018CF67D41DA2EF0" modified="2018-01-31" version="1">MPHLTSLRVSDVSGAWFEAGHTISFGHIEELFLAGDVPALVGIFNCFCFPALKAANIYFTSLQAVPVAPEGVTAFLYLFHNAVSASSLHSLELTIMPAQPPGRELPAIRDRLAPILPLRDLRAFVLGVSRTIATFDDADVDALARAWPNMERLSIGQGSKVPESMTNVSFDALYCLYRYCPRLEELSIPRIRWPTIGVHSVPAPIRDGSQATSGPPGTRKPHPLRRFTVRDEYFVETMRAGSPAPELSDEAAEAMARYILDLFPRLEPEQYKKAASEARKASDAEARQRGNLESIVRFDGRWRQVSGLVYVLCCARDGLPTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY83</accession>
    <name>A0A2G8RY83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY83"/>
    <dbReference type="OrthoDB" id="3027208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="50"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="354" mass="39620" checksum="6322B75AE6214288" modified="2018-01-31" version="1">MSPDRQETRPLKRSRTQAAQDDLSGSQPSSKMETTLGDFERSEEFWLEDGSIILVAQQTGFRVYRALLARQSTVFSNMFSSSTPNAEEMVEGCPVVYMSESAEEVAHLLHVLLPTSQRTLFSRNFSFSFEQISAIIRLAHKYDIQDVLDQAIASLAHFFTSDFDTWERNKKQVVDVTLAQSICIVNLARLVDWPSLLPVALYQCALLGSTVLGGYKHDNASVEHLHPDDLRRVIRGRNRLAKEANEMVAEIFISDPCARCTTRASCRDALRRMLEIAVADDGCSSPEVLRSWDCGIENWGEEEGLCDACQRAAVERDTTARRHVWNKLPDIIFGLGVDGQVADIEANDVISETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYQ0</accession>
    <name>A0A2G8RYQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYQ0"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="232"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="585" mass="65678" checksum="BD0A2608F8430315" modified="2018-01-31" version="1">MWLLNTARAELKFFATPESVPGGYAILSHVWDEHEDTFQSIQALRARCAEDGTNPRDLASDKIRNFCTLAERDGYEWGWDDTCCIDKTSSTDLSEAITAMYHYYSLADVCYVYLRDVPTDCDLPAPDSAFRKSRWHRRGWTLQELIAPPLVVLLSHTWEPLGSKADLARLLEEITRIPADILDLRDAPSSYCVAARMAWAADRETTRPEDEAYCLMGLFGISMPPLYGEGRKAFLRLQEEIVRRVDDPSVFAWGEMYDRRDSDMLSEAEPDQSSLNPDRLFARSPSDFRLGHHMRCREKFTPQGYPILGGYANFVSRADLSKLPTFTITPYAIEALAPVYAPFPQSNFIVVLLWGIELRPPGLPPQNLGVLLRLAGVHPAEQARMEDRLHRTHPSDDRSTRPAPLYPKHTHIPRSHVAELLRSPSVTSSALQLQGSDGIEDPGSQRTMTLAFTVQPPGGDVRFSIAIHLGLCPRASEGDPRHKHWAKAERQRAAGAGRPRSTAADPEGKESEHEHEHDCAKHHVDEWKGRSRTFAIGPGPSDALQRLRVKLAFEPYALNPAWVRKVHIGFDVGRASPVAKQPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYZ3</accession>
    <name>A0A2G8RYZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_11234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000040">
        <property type="protein sequence ID" value="PIL26707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYZ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYZ3"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL26707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="545" mass="60484" checksum="4401287DB51F1130" modified="2018-01-31" version="1">MNANNSGSASVSGIAIVLGLAAHQVFRKYETYNINVHAAILFAPPVLLTLFADSTQRTLVRALLANLATYLTTLVLSLLVYRVSPIHPLARYPGPIGCKLSKFWMGFACISGFQHRYIKSLHERYGDVVRIGPNELSIRDSTVLNALLGTSGLPKGPHFVGRLLTDTRLPMVGIQDTEMHLRRRKNWNRGMSSAALREYELFIAKRARQLVDRLEEHKSTVTAIGNWFNYFAYDFMSDMAFGGGSELLEAGHDQGNVWALLEEAMFIATFFGHMPWLGMYFGKIPAATGNLMVLVNACAERTTARLKRGSEKKDLFHYLNNEDLPDKAAPPVQHLVDDGILAIIAGADTASIALTSIIYCLLTHPGAYARLQAEIDRFYPAGEDALDPKHHRDMSYLTAIINETLRLFPPVPGGSQRYVPHDAKAVVVGNIVLPPGTSVWPHVYSHHLDPRSFAPYTAEFWPERWLLASGDLSLSPSDPAARGLSPASPEFRHDEAGFIPFSIGPMNCVGKTLAMQEMRMVLCAVLQKFRIRMEDGWDSKTYEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ66</accession>
    <name>A0A2G8RZ66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ66"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ66"/>
    <dbReference type="OrthoDB" id="2757214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013916716" evidence="2">
        <location>
            <begin position="28"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="47263" checksum="82DC689ED37266B4" modified="2018-01-31" version="1">MEMTWWSRTALSTTLLLAVLSVQLAQAGNTTCIKSQLSRQQFPVTTATTKSPFSSACYAWCGYRPSRRTRRKLKALSCQQDHQDTGGIGTDAPIGSFDVYRKSCLPAKNHTLPDNLQRAVCNNDIRLDDFLYGGWDDGSWCDVSRLPVAFVPFADSNATPGFNLHFLNADIRSLETYIRVLETDIHVLDSGVNGSSQWISRKCGFDRTNISRSTNLAVWMWTRRRTQGASKGTEWSQSPRFERMYSLPQASTGADAQKIVLAQNKFGVDRRECDTSNPVASSLLHSEWLTEPHLTAVSWKLPYRNPDISPEAPGRNNATAQPTSSPTDIHPNHKVSIYPVDGSQLRSFSAVYGTGSSQGSVYSGTHARSHSVSEASVSLSTFDFAGSQVPNDAQTTRSFPRSVATNGFTTLHSVSCAPTYVRHKDRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZF6</accession>
    <name>A0A2G8RZF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZF6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZF6"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="2">
        <location>
            <begin position="133"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="314" mass="34869" checksum="EDD91236BB41F87C" modified="2018-01-31" version="1">MCAGNPLLAAHAVPLAVIARVVSLLDLKLRSKGSYECHLPPTFQSWFTITNLHVWLLTVRLRALPPPLGTNYVQGLIDHFFLDIEDRVRTILQPVSANSIAPPQNLRPYTSPSEFYTVANGQGRPRPKGSTPERLVTRQMKIFKEQWAGMGMSFDYGLAHSDAELAAAVWRNLLGARGARGIAYPSSDCADRDTPFYRRTINLAGGAVDKVEAIEKTGYEVEEARDDGSGVHDYPPAEVDKYVRYPELMATVVEYVRRELVRLESVSDEEIIGMQELGTESRGLEILRFGQVKRADGRVASLSSEAEPPREDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1B4</accession>
    <name>A0A2G8S1B4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1B4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1B4"/>
    <dbReference type="OrthoDB" id="2757865at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013869951" description="Transporter" evidence="1">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20727" checksum="BB5192B78FE3BDF7" modified="2018-01-31" version="1">MARMLFYAIFATLCASVFTQNKLPPIVVPKSGDVWTAGERQTVKWSTDGFNVYDPSLTPLPGIIYIGHLTETAQQIWFNAPLAQNFTLADAQVDVIVPALPTAKNYFLVLFGSSDNWSQFFTLNNPADPRGTGTFGTTITYSLWGLCLSHHACKLDFDSDFSRLVLNLDNTFISTTLIPILIPVRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1B8</accession>
    <name>A0A2G8S1B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10495</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1B8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1B8"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="417"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="761"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="887" mass="96458" checksum="6AA249D92AEA9531" modified="2018-01-31" version="1">MSLISDTDYLIHNLRLNYLRHIDDPYGARLISLDPSFHSNAYIDASGLADVDRWPEVAMPTSPTPSDDESAPTVRRRHSGFPGANLKYTTTILGPSRTGAMGLRVNGKRASMPRNSVRLSLRRDAHTRNPSALDVPPDETPITTEVIAATPTSPTKPDTQSSPIKERGRESSGPLPIQQNGSGGGASTSPGQQSEGQRPVPAFVPKINFKGAAEMEARRRQRLLARAHPPGMAPRVPMVPMNLNPEESSSSSEDEPEPEPDETSDDGLADEEDEDFDGEGDDGMEVNEDEFNPEFAASREVGMNSDSASEIASLLSGLSTSASSMLASSIPPSTSARVSRLSPVREGKERERPSVSPERDDGQIDAMFEMVTPAPSTATNSQTQHPRGSSSAKLAHTVQTPAGMFERKPVAPMRPIKSALTAMLAATSNSSASNPFAELYSAVSGRAESESMVVRVFFPMAREPENQALDLNVRKDATVEEVLGFALFTYWEDGWLPKIDEGLSGEEDPKWAIKCSAVGWVMRIAEEDGEVDEDFPPPDRTGKISKFNFEAYAVLEATASQIQQNKNLESKIQRRISRVVVKKKSTGLLNATANTGALAPTTAETLLGTSAGLFGSLGSSVMFPSSLGPSSSHGPPLFLRIRIASAADEPGHVSTTIQASGGMYMAEVLEAVVQRRKLSDAKDYALVVEVGDVKMNIPLDRTVHSLQGKRELILMKRNMLREYGVEVRERKGTTDPNASIFTADAATQEQTMSQMLDYNNAYRKYTVYRKMPMMVTRSARMLTIDGGYIHIIPTVTKAKHLFDSGKTSSYHLKSVVACQQSSKNSATFKLVVHSEADRNKRYEFEAESPKLAAEIVNTIRQLKTTLEKPGGKASRRNTRIGTATARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1L5</accession>
    <name>A0A2G8S1L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1L5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1L5"/>
    <dbReference type="OrthoDB" id="10482749at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="587"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="625" mass="69935" checksum="37547DBBC97678B7" modified="2018-01-31" version="1">MSADGEKDGGQDGALTNELLSRQALSSSPANVLKYPPHREMFYSCDRYNKTEIDGAVTDGRVQRILGRWTMLVTWETDVGGARVPCRTVYIVDFHSRSGGDRFNFAGISHFDYAWPSVGASFFGHCIGADDWGRGLPTYYTFTKAFDGPTPPEFYQVRMDSDGRTLIGVRDSDSHFSSPNKAWVIMKKDIAPEVMVYYPSREELIVDRTSALKHFMLSAVWHQVRRQCRPMLFANRQMKRMSRILYLTGKESISTLTIAEKMEHICLINTLVPADLHFLSYKSLEPTNTQLTRDLRRPTGVPSHIPLISPRVGFLLIEWLVPEHRRRVRFELPEARRPRDPSLPSETTRTTSFGTSILPERSLLFSGNDSVLNVAPVIPPKPEPESPMWQDRRWEHPTILREPEYIVIQPRTRTPSQWSTSVYSSDRSVPSAHGRARSSPRSPSQVSTSVQPQTEPSSSTRRSQTPSVLPSLSGGRPHHYGPPPVIPDPPPVLPPGAIYVPSFPFERGPSRIISSGLSSRSSSPSSNPPPLSDTPSPPVIPGRLEHGITILPPKFGTIEENSSPPREPSRESVKDRGDLHTVHAIQIVLGMFFVFFVACLTIVCVFVYYSGGSLTISLERKGREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S211</accession>
    <name>A0A2G8S211_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S211"/>
    <dbReference type="STRING" id="1077348.A0A2G8S211"/>
    <dbReference type="OrthoDB" id="2753952at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33239" checksum="C3B4CC69639A960C" modified="2018-01-31" version="1">MPPRSPRLRRSNAAAFPSSPPILNLSHDTLALVCDLLLPVDVLNLSRSCKSIHNFLHQASSKFVWKAARANVQGLPDCPKWLSEPQFASLCFEDFCFRCLAMDTYSRSPLWPFGIRYCLPCRTATFTTKPLKDFPAGGGGALSRKVLSFYVRDVQEFRAALVAKVGADLAATAALVLALLQEKASDTKDRVEFARECKAWHVQWKAQLAAAARAVKVQRQQDILRKLEDAGYANEVRELGPHYEGLSQEVRAVTDQARPLTEREWNVIRPTLTAFMDGRRELGVRVAFVRQIRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2Z9</accession>
    <name>A0A2G8S2Z9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2Z9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013815946" description="Transporter" evidence="2">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12601" checksum="34B0E21088E6B1B5" modified="2018-01-31" version="1">MHILKFVLAALAVSGAVAAPVDGSPKSAATRVAAAPTSSLPHHTSSHSHRSHSSGSHSHSHSHHPRSSGSYSALTHRPSGSHSRHPHFLLGSPYAHPHPSRSHSTHSHRPSSTPSRSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S391</accession>
    <name>A0A2G8S391_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_09652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S391"/>
    <dbReference type="STRING" id="1077348.A0A2G8S391"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="600"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="539"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="956"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1062"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1111"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1133"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL28240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1152" mass="129816" checksum="883EEB8C15EE6816" modified="2018-01-31" version="1">MPARNAAPFDLESLKTALPKIFDQVQNTTANHQKNFIALYKLHTEADKIQTPAQNGRSTKIVGEKAFWEAFDDLALRVVDVKKGNAVADRVIKFMAGYAKFAAEKDVDFRKANDMDQEEDTFTDRFLSHTIRLFLEGCTAKNKVVRMRVLQCIAEIITNIKSLEYCEDLYVDLRAALLDRLRDKEPTVRAYAVSALCALTEDPEDLEDDEPTILEMLVDTMTYDTAAEVRRAVITKLRASTPVLPDILARTRDTDATNRKLVYTHVLEKHCTGSSDDARVGFTHPRALTIAQRELIVRNGLGDREDSVRKAAAQLLAAWVDVVRADGSRLPKTEEQTKTEKSAETINDLVAFLNLFDLTEGTVAEDALGSVFDTRIDIFEHIEFSEDYWTDPTPERAFLARVFVDKCIAKDARVRLDETLPVTTHMMFRIQAVYNSLVEHIQADSSSKDEDEDAAAAREEVRLDLELTVAELLRLAVNLDYQDEMGRRKMFMLVQGMLAQEFLSEELLARPLDVLRVLSESEKDLIRVVVEVVHELRDVPEEEGEGEGVKAEAEVEDETTMDADETMTEMGESPRKGRKQKPVEQLTPEQKARRDTIDLRCLSLCIGMLERVNSTFEENEVLEGVLFDLIIPAVKRREMALRERGLTCLGLCCLIARKMASSSFQLFLQQVKSAPEVLKVRVLQIIFDILMVHEGVFLGPNSTNNEKIIVFLLSLFEGEESDKVQAVLAVGIAKLMLGGLVTDERVLQSLVLVFISPETVGNQELRQCLAYFFPAYSYSSVANQRRMQSVFPQLFDQVVKAFRNWEGEEGMVSPSQVATMLVDWTDPLKASEVMKGTRREPHKDPIHIDLAVDVVRAALAGEYDNKDEKKALCQMLGKLYLPDEAEDDKLRTLKLLVTSLRSRRPPRDTASKNAVIKFDNALSKKYEKQLENFSEDELRKLEELKELFEFLDDIIPLEDDEEDPPKKGRKRRSMSVATTTTTSATSGDRSPPPSPRVKSKAKRRRLSQSDDESDDDDARTETSRASPAATPVPTRSMPKRNAAEKGKSATKKAFQQPIVISSDEEEDEDDEDDDDEGEDEDKHAATPVAKSKARRAAPAEKSSSRARQEAQVDEDIDDMLEEGNVTKDSIMDSSEDEEDEADEEEEEVDNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3B7</accession>
    <name>A0A2G8S3B7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3B7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3B7"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22125" checksum="C63F44B597369856" modified="2018-01-31" version="1">MEDYTLVTIDLLKKPEWYSLKVNLAGKVSHTLLRFPRARHLDSRAVDTQIPAITLPPGDPVLRPKARILVVITDSKVVDAFRGFFFTGVPADDSLFANFVAFQALLPPTSGFAVGEWSIADVAVGPYLVRMLMLLEHEIGKYPVGEGRKVLETLRGPRFVRVMKYVEDVKAWPSFRATWDEAATLAMWKVNPAIQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3X0</accession>
    <name>A0A2G8S3X0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3X0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3X0"/>
    <dbReference type="OrthoDB" id="3265210at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="201" mass="23150" checksum="9F514C91BFC70735" modified="2018-01-31" version="1">MKSNGVLCNVKARLRKLPPVRLLKNDGVLPLSNAWLRRLSGDGRLKLRLKRNSNAKLLPLQPDETLCTANFGSIKNRRDCSAEFDKVPTFKGTKPNFYAIPWPVLQSWTTLLPENITEDAVEEFFAHLEDRMTTEEFKAYVSKAHKRFHPNRWDARVILSKDNPELTEMLAAANKTVIQALGPRYDRLFRAEVIHNAERWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S599</accession>
    <name>A0A2G8S599_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S599"/>
    <dbReference type="STRING" id="1077348.A0A2G8S599"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="476"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="688" mass="76958" checksum="79A9997D4CD42584" modified="2018-01-31" version="1">MASTNSSSSSDVEATTSTVPTPATTASSVDVAPLNLDVKFVDSRWDEETDSWKYNDTANPDIAAELVQPMGADATDSDSWEAYCFVVVRKHSKMSEDSRRTITFEIVLKSPYLITACQSVMADVRGVSWTSQPINLDPKMLIAYFPRLEAYEQTLSSRSDRTDEDERVLKSLGVLLAHMRKHYRQTLARIATLVANREITFDLLYAVLLPGTVIIRRCPVTRETRALKLLVANQYTNSCGQKYWSMECEYLECTTSEDEDASQDIGWGENTASPVRFGMSDAGAQIRWFDGVEKISSLSAFPIEFHPDPSALKSMLLERARKWVSLCGMHHVHYQGNAGRYEWVSGNLKLRRYSVRSRIMVDKAGFSRIDADYDLPNPERMLQPRANADDGLYGLIDAELLLTPPIVYGFSLSDKLWLEFNVNHVAPIEWNDEAFAGLVLSPERKDLLRGLIEAHGRLATGDGPARFDDFVRGKGQGLVINLFGPPGVGKTLSAEATSEHLRRPLYIVGSGDLGTSAGSLDNALREAFELAAAWRAVLLIDEADVFLEQRSLHDLERNAMVAVFLRHVEYYRGILFMTTNRIRTFDEAFLSRIHVALHFEELSVGTKVEIWRAFLRKAGLGNAEVEEEGLLARLAEREVNGRQIKNACRTATALAVSRGERMGFSHLEQALNAMEEFMTDFAAISESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5B1</accession>
    <name>A0A2G8S5B1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5B1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="160" mass="16972" checksum="28198E52E1B13C8D" modified="2018-01-31" version="1">MRSLNLPTAAIDDHPIISISVLTGTDNDNPSPFANPAEANDPPPPSISDANQGPQADAPPDTPTPIPSTNTDSISLVSSSTVPPSYHTQHSSRDLQFFPVSPSVPLPLRSPQEPPTPPPALVPERRPRQSRVRGPRSRGASQTLPRSMAVDPPPRRSPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6F7</accession>
    <name>A0A2G8S6F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06983</name>
        <name evidence="1" type="ORF">GSI_09411</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6F7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="12375" checksum="4D23B65C7B88EE4B" modified="2018-01-31" version="1">MVEIYLYTHTVTVTTYLEDIETPPSFIFTSDYKANERIFQLIHTNYSGWVDSQVHAKLMQAFPDAYDSYLSGEPFFPWWEYPDLAEAADKARAKWGHPALHNRSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6K9</accession>
    <name>A0A2G8S6K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6K9"/>
    <dbReference type="OrthoDB" id="2726580at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="317" mass="34160" checksum="A60CE11F79621DC7" modified="2018-01-31" version="1">MYPASQTPASQNAALNFPVAFGLCRMSPLGVASVVHHLSALPLLEGQPLKRVEAMAIAFLASSGADDNDHAVLDIGVHCVHQEAHSTRARYNWRDYLRKKYKRTLIDILTWMDRLSGGGSLMIYASGMRPPSAPATVEEQKLDVFASRQAVNMSIGARVACICIIQHFAENIGYPIMQNWDRAKGLQAGGPRHRSTTQRAPSNRNAGQPLLLMLSSPAFTIYPRVPGTLEPLLAEEFGVTVGQPIPVTQPIPVTQPNVATTSNAAPPAAVVLTVTLPSPTSGFHYCTTIHHYSGANSMLMMAMLALFDLLANQAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S725</accession>
    <name>A0A2G8S725_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S725"/>
    <dbReference type="OrthoDB" id="2762308at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="495" mass="55347" checksum="BAC71B0AC4318CA6" modified="2018-01-31" version="1">MHSDSDTTAHTEMDTLIAALHPHIAMSLFKYNLYPPRSLGPRKDTDGSLELARAFATLFRFHPGCSAAAVAARPTVAESRARSTSFSVCLSPSTPPDFESSLAKWLAQLRDLREESESMDRDSTALTFSPSEERFILYTYGVCYPAMHRLIKERGFGSWISFVKERKPVPGYTPSKPTVEEAELAQKYADEIRAFSGLVRGFAERVAHESLGEDGDVLRFHKLCVAIRDMRSNDGFLDYLDTYVRTYLAGSVPRQLGEAELNYISPTDYGVIQPRLAYFHLPLAVSTIIALCRDKKISLDDLQGWALLDPLKGARRFSAVIEESYLAEHFGKERGIRWKAVVEAFNRRWAVGPMGYDMGYQLDAGTNTMSTARLVVVHPEIALIQHLLDSEGGENPNLKRAKAHIACSRTPCYATGAYAVAVNQAFGTRFTMDVDDPDWCRLDDVEPWILPENAPEGVVAKTKESLLEDLGWLIVQWMGDTGFSTVSSDDVFFWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S773</accession>
    <name>A0A2G8S773_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S773"/>
    <dbReference type="OrthoDB" id="3262473at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="206" mass="23401" checksum="C523962C3BA775B9" modified="2018-01-31" version="1">MLKRQRSSTSFVPDSYAPQESSIDMSERAAKRMRHLPSPQSQVDKDKALWRAGWSDGEEDVDVDELINGPSAPFVQARRLQHAGEYKHVNSLLHDLHAEQRHRMLFSTTSSSTQLPPISHWRPHIDDYDHPIPSPPNKLAPVAPPYPQPQHESQGGSTSFMISIPSKDVSLVDHIEVQRVTQQYENTNRYVRTTLRAILSKLIVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7C4</accession>
    <name>A0A2G8S7C4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08282</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7C4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7C4"/>
    <dbReference type="OrthoDB" id="409173at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="607" mass="65095" checksum="D98D26A33D739A8B" modified="2018-01-31" version="1">MSLLDHPERAAVYRTPSLSDAPSWRARVALAFRTVTHHVTKHVGVGIICAVAYFDPGNWSVDLQAGSLFGYRPMLFVILMAGLGAMVLQSLSFRLGCVTGLDLASHCRVLLHDRPRHRRLIRFGVLYPLYALSEIAIVSTDLAELLGSAIGLCLLFPALPLWVAVLITASDVLIFLILGDPSRGHGRPVKVFEYTVITLVAAVFVCFIVLLVRVGPDWPQTFLGYVPSKALFQRKPDALYTAVGILGATVMPHALFLGSYLATQDRIGPAPTLPDPALTTASGPSNLRAKLGAWLQSLFTISRAERIAASRNYRDKYGRQNNELDFIRAHLSHGLVDVIASLLAVAVPINSAILVIAATVFFRDEPGSPSKNIPAGLFDAHDLIKEHVGKVAAFIFALALLCAGQTASITATLAGQIVSEGFIEWRVSPFLRRIITRLIGLIPSVVVAIAVGRPGIDTLLVASQVALAIVLPFVAAPLIWLSSSKSVMSVRKPAGDKEVASLPTVTGPPTAPTPGATPSRPDVNVIEEVDLSTGRSLGSLNEKHVGALVEKHEHRLDDVGEEASLDEDAYVSFASGRVVTGLAYLIFFFILAANIYAIVMLALGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7X4</accession>
    <name>A0A2G8S7X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7X4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7X4"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="84"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL29876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="543" mass="59899" checksum="BAA21AEF7A31A127" modified="2018-01-31" version="1">MSFPKPTEHLPPPSLHDMSSSQTSVTIDPASEDANVGEDINTQFEHQAYGPAPGEKPEDSFEVIMGPQDPDNPKTWGRVYRWYITMAAALLLLNATFASSAPEGIVFQLMEHFHFGSEIATLTIAIFIAGYCVGPLVWGPLSEEYGRKPVFIVSFIFYIAFQVGCALSPNTAAILIFRLLSGIFAAAPLANSGALIADIWDADTRGKAMAMFTLAPFAGPAIGPTISGFMSVAGVSWRWVFWLLTFFSAFCLFLIVFTIPETYAPILLVRRAEKLRKETGETRYWAPLERNKPTMSQRIKRVVARPFIILAREPMLIAITVYMSFVYGVIYLLFEAFPIVFGEGHHFNEGFVGLTFLSILTGGAIGVVIYLLYFNPRYEAAMARYAPGPVPPEFRMEPALFAAPIYALSFFWFGWTSYPSISFWAPLAACVPMSTGVIWIFLGLINYTIDAYLFVAASALSATTVVRSVFGAVFPLFATQMFNAMNPRWASTLLGLVALVLMPIPLVLRRYGPYLRRKSKYAPTAKGSAPSHKEGEKKGADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8H8</accession>
    <name>A0A2G8S8H8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8H8"/>
    <dbReference type="OrthoDB" id="2758168at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="420" mass="46577" checksum="647FE5D4549D78CC" modified="2018-01-31" version="1">MRVPVSLLIHPTPFALLTPWKALPRSIVEFSTLHVQRRHRGSNASLGQAFSTSTGSLKPGDTTRLKTTNTTAGKITRSRQKIRTLDPSKLTPDDYIDISHKSSPTLSAILRSSNSPPASPRSNPQIIWVPCASSSFPAGTHGFLYYHVGPYSSPIAGELRIRVTSSRDPASFATGSDLLDERSMLWRYPLYKMVCRPDWSEFVALLLQDGLVSQRTLDLVTAAVAPLRRASANTQPPGAASSDERHPSVSPSNPVLSAFGQEFPFRYTLGINFCGVFAGPDTIFTHRVRHITTFWALREGKRFQYFPFAGSAVCCFERSMLPEHAGKRVVVIRVKRFIDTDPIRPVPPPRGANGRAHLVEQLRPREGELLKVAIHDRVQPWAADVDKVWKESGAHGGTTPWKVLRVLFENEELYGSPHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8M2</accession>
    <name>A0A2G8S8M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8M2"/>
    <dbReference type="OrthoDB" id="2750355at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="180" mass="20082" checksum="A756B64CEC8FE86D" modified="2018-01-31" version="1">MNELNMPIHPNVNMDIMLAILSHSPPKTATSIMETCRFLYHEGAKVILQQPVFLWGSESQILALLRFIQAEGLSRCSYLRNLVIIIQISERVANIQPGRPSELVAADVNFDFSTHSSAALSHPFHLLQRSVSTLQRLAYTSSGHPDIDNTASQYPQIIYPEVRNLVLGRSGVVPNLTSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S985</accession>
    <name>A0A2G8S985_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_07508</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S985"/>
    <dbReference type="STRING" id="1077348.A0A2G8S985"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL30324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="324" mass="34505" checksum="556995B89FD8872E" modified="2018-01-31" version="1">MSTPCDSTYLSPSSTANAPLQNSPQSHWSRVRQYVREPAAEFLGVMILVMFGNGAACQAQLSGNKNVASTAYGDALSTNFGFAVGLGLGGWVAGLTSKGHINPAVTIAMATFRPKDFPWRKVPGYILGQVLGGLCGAGIVYANYIHAIDLVEGGRHIRTVPGTASLFGTYALPYMTSVSAWFEEFLGTALLLVAVCAMSNTKSGPTPPWLASLVLFITMLGISCAFGMQTGFAINPARDLGPRLLTAMVGYGAPVFTFRSHYWLWCPILAPIVGALVGTFFYDLLFYDGADSIMSKPRDCASAGLQEQTDSSDLKHVRSGDEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9B3</accession>
    <name>A0A2G8S9B3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9B3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="23051" checksum="D220FD038C5A7F35" modified="2018-01-31" version="1">MAFRMRHLLTTHPERMLWENLHTPQNIVVPVGLRHIPPGTKLYLPSASLSLHFPDVTLSSVDVPMILEPPHERRVGARRRAAGPSGDTSGSEKIEICLLSENYDAGRPSSSSFAADSESFIAPALHTHSRDDLIGAPYTPHHIIMDAFYYLSAPIPSQEPTSESSSPSEVLEVFVDQDTFGFIGCTRDASSRHDLRARLSPLQAILTGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9E4</accession>
    <name>A0A2G8S9E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9E4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="237" mass="24779" checksum="14921E8595ACDBF8" modified="2018-01-31" version="1">MQPQNAPGPGTGMPFGQPQPYAYPMYPPSPRAGLLVTSPVYATPGPGSSFAPPTTFPMSNPTLGHGWTTATRVQHPMGPPFGMQPGSGTVIRQPMHEFIQDMRSLYDPPGIPQRIGPPPGMGPMMPGLVPPPGTPGYGPGDPNDIRYGLDILSEVTVTPVPRSSDPWGSGVAGPSSSAIPAPTPTPNLSTPQPPGPNPNPPRRTNAMAWDITELQLMSEAWAAGARRNRGPDDTNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAH1</accession>
    <name>A0A2G8SAH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="10" type="ORF">GSI_07299</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAH1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAH1"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="268"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL30598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="457" mass="48392" checksum="8029091BCB4168A7" modified="2018-01-31" version="1">MASASTSEITHPVVFTTQTPYPLPSQKFMIPATWKRYQLSQLVNKALSLPKPIPFEFLVRGEVLRGTLAEWCAEKGVGEEETLEIEYFESIMPPQRMSSLPHEDWVSSISCQIPGYFLTASYDGAIRTFDYSQKLLHTVLAHTAPVSSIAVVPSDSPDSQLIASASHDLTARLTRVDLSPTAGPSKAQTLASLHLHTAPLSSVAANASGSHILTSSWDGLIGLWDTSIPGTDEVPAEETAGGDRKKRRKVAEDDDAARPKRKAPTAVLKSHTARVSRVVFGRDGAAAHAYSCGFDSTVRTWDVENGVCTGTITASSKPFLDIALSQDGATALAASTDRTVCQYDLRASTSSATTPSVASLAHPATPSSIAVPQPGSASAHQLVTGAYDGVVRLWDLRSTKAAVAAFKAWEGGKGKDEGPKKVLSVDWARGMVGVGGEGGVEVWKVGEGERVPIAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAP2</accession>
    <name>A0A2G8SAP2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAP2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAP2"/>
    <dbReference type="OrthoDB" id="2930561at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19884" checksum="3F24DEE00FA6BD44" modified="2018-01-31" version="1">MAKKPASKPPNSKSQKGKIAAPATMFWSERNMKMLVRFLVKHKAMEYKGAEKSGDACKNKWTQVRAEFWAIHDLKNASGFSYSDSTGVGIMAEMEEVWQAFIYPGWPYYNKAIKIMPVKAKRGNIFHPAHGGRDSINPEDEDDKDEDVDELDGSDEALAAEDECEEEGSKNSEDSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAV0</accession>
    <name>A0A2G8SAV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07063</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAV0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAV0"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="542"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="663"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="695"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="759"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="776" mass="82232" checksum="C740DEE06FFB0BDD" modified="2018-01-31" version="1">MASTPSKAKKSRTKPPRGRPQATSAISQPAVEDATTSTYLSSFSPDGRLFAFLSLAIDKHALKVYDTTTRRSVAEHIVDAARVTSLCWARLDLAESGRKGGADEEGSRKTKKKKRSSLAADAATSSNAAPQLVVLGLSDGSLVLFSPTHGRLLRTLSDPSSSSAVLAVTGQDPDSADLHTLWTSSADGALRIWDARSSQVSQSLFSEDRIPYTALSVRSSDEEGVSEVLAAHHSIHLLAIVSDSQKPKTLAKFTGHASPVSALRWINRSHFLSSASADRFINVWEAPSVPKVDGKIVASIPLDSDSRIIHLSPSPPLEASVDRLLLTLSASGKVSVFTIASDLATSSPAKGKSAIPTLAPKSVISSSPKKGAATLTILTVAHADEKAGRLRIASVTGGVQLAFDAVDYRDQSGNFIPDVSVTIATPEAAVGQADGKDSGAPNKRYNEASSLAVGTGAELGQDRELDDLVMRDVDGVLDADLAELSLGQRLTAVQGAPVRGSESESDSEGEGVPNGEARAALVDAVPASSLTRTLIQALHSSDTRLLETCLAHSDTTLIRNTVRRLPPQLAVPLVTACVERLGRGARGNTLKGGGGGASSQRGTALINWVKAVLTTHSGHLMTMPDLVARLSGLHATLTQRLTLQESLLSLSGRLDMVMSQIEMRSSGPPAPLPMPKNKSRNKANKPRESRRYVEGESEEEDEEQMEVEVESADEEGSVEDVELGGSDEESVEESDEDEDDDEDEDEDDEGDDPTFGGFIDDEAVESDEDEDEDESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBG4</accession>
    <name>A0A2G8SBG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBG4"/>
    <dbReference type="OrthoDB" id="2745096at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="204"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="436"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="792"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="816" mass="90161" checksum="25441BB0E5859350" modified="2018-01-31" version="1">MTLSSGPPSRGPTSTFEYNPAGDAASPPRVQRVRTLSDVSGASKHDQRRLDLNREMVWREQPLEAWFQSCLPGADPTGVTFAPFKVELENQEQGMYVGLRDGLNDCLRAVGWDGYEALTTDRLPDSSASGSSGDALRPDMGIYPTTRARTSPSDDSLDARVAWAWLELLIEVKWDPKAAPFSSRYTPRSPFLPTGRERCLSRGQLAEYAVEQFNRQHRQFLFMVHVMRDCARLLRFDRSGAVVSEEFDYVAHPEVLGTLLFRLSRMGRAERGHDPMATLASECEAATFRELHARFHADSATARGLRSAVAEGWPIVKVTMDAPFSSAGAAVRRGAVPTRREFLVGKPASLSLSLLGPGAKGFVAYDLTTGAVVFMKDSWRLDSRDVWSEYETYLQLRERTTGELYVPTLLGGGDVSFDGERQRAACCAESPFEDAPSLVHCRLVFKEICRPLEDFTNSFELVKAVTWALVAHSKAWKQCGILHRDVSVKSIVIYDSDDLGTPTSIGTHETLADWDVGWWPREGIGRDGAQIHRSDSWPFTSARLQEHPDRQHELADDLESFMHVLNYCALKHLPGAASTEAESAHLTQCLYDAVVPSNSSYPKGSPLKLEKVQNGTPFVNLNGLPAQHPLAGLLAELSQLCKQHYEHVVLPESPPRSPSPEEIFARGSCGGAHGVLPDYDGDLLQVDSPDSDELDGWSTRTFTSPSSTNVNIALSPFRSHDRMVGACMKAIRKVWPAVDRRDRAIPTRTRTRSLARMGSRVGAKRAWSESDCSETDGAGEDSKRKRARRSSESSAALSLGSVTRNAGGLRRRRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCU4</accession>
    <name>A0A2G8SCU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCU4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCU4"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005371">
        <property type="term" value="F:tricarboxylate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015742">
        <property type="term" value="P:alpha-ketoglutarate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000078">
        <property type="entry name" value="Mitochondrial DNA replication protein YHM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="231"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="319" mass="34243" checksum="5F1B29E1740D01A4" modified="2018-01-31" version="1">MAITKEPGQKGVSWSNIAVGAIMNMFVGGEFVHGTVFPSPVLLTEKLQVTTLGQPLEVLKTQMAANRSQTMFQAVQTVWSRGGVAGFYQGLIPWAWIEASTKGAVLLFTASEIETATTAMGVSPAAAGLLGGMSGGIVQAYATMGFCTCMKTAEITRHKQAAAGITPPSTWAVFADIYRREGIAGINKGVNAVAVRQCTNWGSRMGFARLAESSIRKMKGKGEDEKLTAFEKILSSSIGGALATWNQPIEVVRVEMQSMAKGAERGEKKTILNTLSYIYKETGIKGLYRGVTPRIGLGIWQTVCMVSLADYVKAWVKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCU5</accession>
    <name>A0A2G8SCU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCU5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCU5"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="289"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="397" mass="44309" checksum="128F02ED7C5C616F" modified="2018-01-31" version="1">MERTKKENASEEREKLRKQVAENTRSIFSYLWPIHPIQLFIDLLWAVARLFSPLAPHLVPLAVFSVTLPLIILLSIGSGYFVWKSIAVSWETELFLQYGDGGIPHAELALWNVAPNQAYDISLHLVVPANEANIALGNFMATLTLSSPSNTTIADVRKPSLPEISSLAFFKAIVLPQYLAPWSYFYNRPGTVDLDIPMLKDFVVGTSRAMAKIELGRRDHWKTLGEGHGRELAVLSGSIRGVVIYHGIRGLISHFPLLSALAASGIFFFVLFIGLVACLMPAVEWHFPSEPDESRQLEPEDKPRRRRRSRHPEYVERGESKSRPKTPTTGRRTEGSSSRSRQLRDTDIKTEGDDDWDTTTYQTPAGAVGTTATANKDGSPTVRRRSSRPSASDDIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCW1</accession>
    <name>A0A2G8SCW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCW1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCW1"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013587211" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="174" mass="19195" checksum="A3E51A0DFBF852B4" modified="2018-01-31" version="1">MARFGLLFLAAAVVGGAVASPVQEQEVLFPGVPGGKKWDWKDCGTDSHLVHINSIEISPDPPQRGQDLTITVDGVAKEQVEDGAYADVTVKAGIIRLLHKEFDVCEEARNANTTIQCPVEKGHHKVTQTVTLPNEIPPAQFTVNIRGFTEEDEDLVCMDLMMDFRILPRSFLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD94</accession>
    <name>A0A2G8SD94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DUF605-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_06400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD94"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD94"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="414"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="198"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL31697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="48075" checksum="6FC8DFAAA5D78F80" modified="2018-01-31" version="1">MVLSLPPVPPELKPITPYLQRADEIATNDPVISYWCAYYAAQQGIALKAKESSARHFLFDLLGLLEKLKNDIGPNDAVHDEPASAAYVENFALRVFTGADNEDRRGKITKNTARKFLAAANFLEILRTFNSEKTAIDLPAVEEKIRYAKWKAAEIAKAFREGRTPTPGPAGSAAAPQDELPPALPDIQFPDLNVVLPPETSPTGTISAPSLPSPPSIVRVHPPPPELTDLPPVDNANHLVPHLPDGLAPPQPPQSPGSWSTVATPGTPSFQVEDTSPAPSESAYSPLGSAGVTRTSFVGGELGSTAEDGVDGETTPPSSAAKSVHFSPSTMGGMGEPEDTFANPSLQSRPSAPPFEVHPPHNDHTFASGPIRATHPPTPVVPSPTSYVHAHSVPLATSPVPDTTVTTMPVELSPQVIARVQKHCRFAISALDYEDREQAVKELRAALRMLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDR9</accession>
    <name>A0A2G8SDR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDR9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDR9"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="127" mass="14063" checksum="ABC0FDFE7A985AB0" modified="2018-01-31" version="1">MASKVVQWLQSPAARDYFLSTHFWGPVANWGLPLAALADLTKNEEVISGPMTTALASYSMVFMRFAWRVQPRNYLLFACHATNATAQLVQGARFVNYWYMGGKENKETSQPAAQPIATSAEAPSMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEB0</accession>
    <name>A0A2G8SEB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEB0"/>
    <dbReference type="OrthoDB" id="2688840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="417" mass="44859" checksum="68F08BDDBC273293" modified="2018-01-31" version="1">MSSCTDRHRPRSYSVFPESSPTPRRQTDEVKGRLSVKRSRPSSIRGPSYKDLAHDQPAEKWDVDLWRKGKRQRDSNAGESSDEGGSSSRLTAIGAAFPTRNAPASPSSASGLPCTSAAFQFFPQKQKLRRRASGPRPGRSLRGISPREGDRISSDEARRMRASALGELRRSVEENGEGLVRRIRDWEQSRSTTPRSPVAPTALETPRREWRRPTFCFGVPEAQTAVAEESEDEDDDDLFIVGGTSSGIARTPAHKKRAVSLSMMNDNIPVASSPFADLGDGDRTASLIDCSSGPSAYSSDDEGHADMDTDLSSSGIFSTPALSLTYSVSTNSSLVSLALPTQDEGVMSPTFPSSTAVVRGNARSTPPPPTASRSEKAIAALTLAIASGAAGLSDYEALRMAEELITLDESHAGELWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEL0</accession>
    <name>A0A2G8SEL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEL0"/>
    <dbReference type="OrthoDB" id="3257429at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013809118" description="Transporter" evidence="2">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="18615" checksum="DC3DA18E522B24F4" modified="2018-01-31" version="1">MRLFVYVAAVLALSAVSVLSQTVTTVNPAGQTVVEVITVDPNLGLPTTQTLQTLTTTATTQTTPPPPPTTTTTTQAQGNQGPVGQPQTAAAGPTIYTYTTTDANGNTEAVVATFTPSFGPTTGGSITAGPGTILNYSSWRSSVGSNTVAVVSAGIARWSVQPRWMSIGVALCAGMTGGAWLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH09</accession>
    <name>A0A2G8SH09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH09"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="90" mass="9550" checksum="D04A30966829EC18" modified="2018-01-31" version="1">MTFLASNPDISDTIAQYTAAFSDNCFLFAVVGLEGMEVERRSINVADTFGSLSIIIDPADWDDDHDDGGVDYPLATFDASPSPDEGGAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH75</accession>
    <name>A0A2G8SH75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH75"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="274" mass="30189" checksum="BD405D6E22D35A56" modified="2018-01-31" version="1">MSNVQLEAYTQLAKRDRGTSGDFQHYSSAINRYPAKTTGPSTSSRRSSSPRASSTDSPPSSTWPTREPSPGHASSTMHPSSSQKNSRRDNREPRVLRSARTLANVAPQSRNSAATADVTMPSLSDMLSVPLRGTTKPRVRSVREGRSNEPRAKACDGLSDRRIGRAMRLWTLRWVRWGKAASVCEENGKLALAPKENRPGCVRRKWETGAATRVKRRTRLSLRVQVKGSLTLILKRSRPPAKERTNVLRSTWTLTSSIDAATVSSADPGTKRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHH0</accession>
    <name>A0A2G8SHH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHH0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="28134" checksum="EA980D165659746B" modified="2018-01-31" version="1">MQNAHPSPYRPPGTREQLDPHWRSLNVAPYSLVRLKETINPLFPAGTIVALSNEIEVRVVPPTPSKHEGQGAPNPNANASVKIHLWRQNTTTTSVLSRDGGNPLSIQHKHLVDPTTGERKPRGSWTKSTQVQLTVPEADRISYLTDPIITPNVNIPRGVDIPPGTIGVVRKCMTRTNQLITKEQELSSNRVDWWYVLEVDVRVTTWEWVPCRDFVNVLNLEALQPQEVVFHTNFIKSKTGQIQVKVLKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHP4</accession>
    <name>A0A2G8SHP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHP4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHP4"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="348" mass="38958" checksum="C899A050F92D3511" modified="2018-01-31" version="1">MSTTTSTTKMPYVRLGNSGLKVSRIILGTMQYGNPEWQPWVLGEDEALKQIKFAHDHGIQTFDTANVYSNGYSERALGNAIKKLGLPREELVVMTKVFFPVPADPSANLFTSGQKPEDFGIINQHGLNRKHIFDSVKASLKRLQMDYIDVLHCHRFDYSTPIEETMQALHDVVQAGYVRYIGMSSCFAYQFHQMQTYALTHNLTPFISMQNHYNLVYREEEREMFPTLQHFGVGSIPWSPLARGLLTRPVDTQSTRAGSDWLIGNYKTEGTANIVSRVEELAKKKGVSMAQVAVAWVLAKPHVTAPIVGAKSVNNLEDILGGLNVQLSPEEIKSLEEPYKPMAISGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHR7</accession>
    <name>A0A2G8SHR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHR7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHR7"/>
    <dbReference type="OrthoDB" id="2755983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="218" mass="24963" checksum="F96FA242C184B9CB" modified="2018-01-31" version="1">MTGFRFVGDTLGPNYARREGELKGGTRQSMDATVESMSGIPGRKMRWTLKAYFKYVYLALRLKLVGWPHDIPFMNLSDITGLTRISRIATLWESGRMYFAPVTDEEYLAALANPLACAPAPLHHSFAPDLGRCDIKKRKYRPKTDPLNLRKGRYIRNGPKSARWVSQMAERRAEGRELSADPIGCFSEDEGPSKKTRQRARRREIRGVELEEDPIEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHW2</accession>
    <name>A0A2G8SHW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_04757</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHW2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHW2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL33307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="547" mass="61729" checksum="DAB408775DD890D0" modified="2018-01-31" version="1">MAFSFPLPLAVAPFVIVYVLWLVFRNFFIRSAFDNVPGPPSSSWLAGNILKLLDHDAWAYTDDLIQTYGPVAKLHSFLGARWLHVYDPRALHAIFVKDQEKDVFTREPLTTTGANILLGPGLLATAGAVHKKQRRMLQPVFSVAHLRNMTPTFYDITRKLRIAIESRVRGGPQKIDMVSWMGRTALEIIGQSGLGHSFDPLVADTKDEYTEAIKSFIPTAVEIEFMRLVLPFVDYLGPAWFRRWLVTLMPQKSVQRMKHIVDMMYEWSKEIFEAKKALIESGDNAMLHQVGEGRDVMSILLRANMSAAEEDKLEDEELLAQMSTFIMAGMDTTSNAMSRVLHLLAENPDVQDKLRSELVNARETYGEDIPFDDLMALPYLDAICRETLRLHAPVTLTPRVANVDTVLPLMEPVRGVDGTLLSEIAVPKGSILFVNLRAVNTYKAVWGEDALEWKPERWLNPLPRSVEEARIPGIYSHVMTFINGSHSCIGFKFSQLEMKTVLYVLVSSFKFELSDTKIHWNFAGVTYPATSKGSVKPEMWLNVSLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI65</accession>
    <name>A0A2G8SI65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI65"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI65"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="137" mass="15077" checksum="C68DDB7BB0BA48DB" modified="2018-01-31" version="1">MADSTEGAPTAAPQQPLVMQIVVRRDLLEAEGWGVGPLMAQVAHATSAVLHETRERPETQTYLDDLKNMRKVVMQTADQVSIERLASLLAAADPPIAHHLWIEQPENVPTCLALAPNRRDNKIKKALDKSGARLWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIB2</accession>
    <name>A0A2G8SIB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="16">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSI_04138</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="16"/>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIB2"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 19" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="249"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="272"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PIL33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="353" mass="39066" checksum="74415897D9E93DC6" modified="2018-01-31" version="1">MAYQRVWFRPRILRDVSTVDWSTTILGQKSSLPVYISATALGKLGHPEGELTLTRAAAKTGVIQMIATLASCAFDDILDAAAPGQTFFLQLYVNRDREITRKYVQHAEARGVKGLFITVDAPQLGRREKDMRMKVVDEDAGAEVQKGHEVKKDQGVARAISSFIDPSLSWKDIPWFRSITKMPIILKGIGSAEDAVLAYEAGVQGIVLSNHGGRQLDTARSGIEVLVEVVSALRLRGYWPDPRFEIYVDGGVRRASDVLKAIALGATAVGVGRPFLYAFCAYGQEGVEKAIQIFRDEFEMNMRLLGAKAIKDIVPEMVDAKSLSSHFVMTPQDNLFQNTYQPLQLAKFQESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIB6</accession>
    <name>A0A2G8SIB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIB6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIB6"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="52"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="360" mass="38014" checksum="393AB5612975E0CA" modified="2018-01-31" version="1">MSELVQTPEQLIHLRTTYVLRGQSEFRLVMASTSYQDPVYRDASARLHHGGASKALANAIAEGLISGPRLIQCGKALSQTGGHADFGPSGGSSGCCAGHSQSLGRTADGVPQVLKATREELKGGADFIKIMCGGGVASPTDAIETVQFTAEEIQAITTTCKQMGNKHTTAHAYTDDSVRHAIDNGVKGIEHGNLISRETAELMAQKGIFLTPTLSCYGIMVRPPFEDFLPPDGKVKNGQVMARGLNALKTADEAGVTICYGSDLLTSMHALQTEEFTVRSSILPSAKILQHATSNAATMLGDPKLGRIAPGSYGDLLVLGANPLDDITVLDYPEDHLFAVIQGGRVISSRVDGLAADQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SID9</accession>
    <name>A0A2G8SID9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3445 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SID9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SID9"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47727" checksum="B91F202C14DCF513" modified="2018-01-31" version="1">MFLNLLVAVFLTAIGLIRLYSKFKSRAKANVGASDSPSSPDAEKTLSVPPSPGSSIPDPEPLHDFDLETATARNFIYANKTLRYPYYQTMAHQPMHANHWIEIDKEYKWYIDQKAQVIRQKGKVVIDSMPDNDEACGELLLELVDYLPKRYPTLFAREGHDGIFNRVTGEHHLSLSGKKGTDALLVVSRLVQDDFLMGREREDGQIYLVGGLIAFPGFYLLSETIDKPLVVLHKPVPHFNEKLLMSVERTLKRFRPDQPFERSSWMIADDRNLFWHHIASAPAVDPNIHPKDLWFRIDHQSFRKLPRTNAIIFGVHPIMRRIEDLADSPLVPALLEKVHLESDTALMTYKAAGKYHEMLLPYLRELTASQIERGLITHEDDVKQFRELLHEKGIPVPVKQTTLAVPTESEVRIAGAGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIH3</accession>
    <name>A0A2G8SIH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioester reductase (TE) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIH3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIH3"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="52"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="431" mass="48623" checksum="A4A299A87F9F0867" modified="2018-01-31" version="1">MSMHLPEITPSIPRSRTPQDLWRFVDRFSANLPVRPTDLVDRPTGYKDVVLITGTTGGLGCDALEHLLRDENVGLVYAFNRKNSHAMERQRLRFAARGLDGSLLNSPKFQMVEAVLHEPDFGLDAELLEEIRGSVTHIILNAWKVNFNVPVTAFEQDIQSVRNFVDFALSSPYIHAPAVVFVGSIAVLDNWKKLGPVPELPIDDPACAFGKGYSESKWVPERVLQNVTRERGLRTIVVRVGQIEGDRMGHWNEREWFPSLVKSALFQKCLPKQDGDITWIPCYEAAQALTELRHSSDPIVHLVHPRPVPWDSVLEPIARELNVPFVPYRTWLSTLEGSVVGEPGSTEQAHARRRNPALRLLPFYREQEEKIEEAHGPEREAMGFVFLSTDKAVRVSESLASLPETAGERALMWLAAWRKSGFLSTSWKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIQ7</accession>
    <name>A0A2G8SIQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIQ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIQ7"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="171"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="336" mass="36444" checksum="601A3A1FA1ED46BF" modified="2018-01-31" version="1">MSTPESTADTPNAPAAPAPPAFTEAWLPGPDRTQFYTRTYPSASPPRAVLVFVHGFAEHVGRYEWAHGVYASRGVTVFAYDQRGFGRTALDQAHRSAGGGYGRTSWHAQLGDIEWWVRHVKKEYLDVPVFLMGHSMVEEDVDTRMEGWGLVLAFGTRGAQGPPAQATVSMLSGVIASSPLVLQTFPASKVLRFIGGKASAVLPNVLIDAPVAIEDLSHDPVANEANANDELIIQKGSLKGIHDMLTGGEHLLASDYKHWPRNLPLLVVHGDADKITSFTASKELFDKVEAADKTFTPFEGGFHELVHEPEGMKERFVDECESWVVGRVGGSGGSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIW7</accession>
    <name>A0A2G8SIW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIW7"/>
    <dbReference type="OrthoDB" id="2762359at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="148" mass="16207" checksum="22F18CC57DC02160" modified="2018-01-31" version="1">MIGITDDGVVPEHELRQWLDAKYAQQVSDMGDLEIPIARAREFLDSPGGVTGCKPHEGTPNVFIRAIPDCDYSLRLFPGNIALQEYCADFVRASTGQPANCPKDFELWSAPTGPSGLTMPSGRLLPNRQPVEDGHDDYHVLDFPAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJA1</accession>
    <name>A0A2G8SJA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03562</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJA1"/>
    <dbReference type="OrthoDB" id="3251775at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="328" mass="36687" checksum="EC39217418872FAB" modified="2018-01-31" version="1">MDAVPASLERNFHDLNATRYMSAAGLIILLYDHLLTFGDEVQYIWSAPATYAKYIFLLNRYTVLGILIAVAYEMCGFVGVAFTDAIILKIMAGGFVISFTAQVTSMIYTLITLLPSISWNSAAGMCILTKSSPILIAVWACPMIFELFVLCSTALNALDRPRTMDLRFHKALQEDGIQFFVSISTFRILNIIFAALDRPSLTFLAVFFIWAMTTTILGRLLLHLRRTECLPPSALTFDPALASFHSNSDIEMEEEDGWDPRRRSRAISPFGLIPLSSKRMSGGSSVHSSEADLPAAARMDSYDDVLHIAPPAYHYRKRSHDPNLRPWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJQ0</accession>
    <name>A0A2G8SJQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_03701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJQ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJQ0"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="222"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL33993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="346" mass="38950" checksum="485404A1C52FE2FF" modified="2018-01-31" version="1">MKECTYTAPSFRRGPPKGYIQALEHRLHQVESVLAAIMSSADPRAQSIIEELSHDELAGYILETVDVGPFGKTGREKRSIDTTKDNFFSSIVTEQPKTASHRSRRESRATRENVIESVISTDNSSHTRMAGPAVLQARHPFCQSVPEPTLGGLAARWVGRQLRWVGATEDQETTRRYFFVGRFSTDPVIRAAAPAWKYGYRDPESDDRAPGTEEDVRPERPQRLSKLLLLSMFAYAASHLDPRDGRAGDDVDPAGVYTKHARTILDTIYHESRSSTVQALILLGIREFGAGSLEEGWLHIGMATRMADLGLNRNPDKWTHNGRELFTEKEKTIRKRIWWACCLADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJZ7</accession>
    <name>A0A2G8SJZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJZ7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="17236" checksum="26A4DE51EABBEC2D" modified="2018-01-31" version="1">MRDGDEYGLSGYRLIKQHVGANSPFVSMQQLWGIRTSNQGPMAPMAHTLAYQNVRHSASSHESSTHPQRQSSPHRRPRASKAIAVAIMGPTLALLSPERSTSTMACNRLAPGQRVDIVCRALSAAREKSVRRIQPQASPRDRSLRWFLRSREHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK30</accession>
    <name>A0A2G8SK30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_03821</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK30"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013634501" description="glucan endo-1,3-beta-D-glucosidase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="50"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="77"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL34110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="430" mass="46104" checksum="B98D354CCC6A0F82" modified="2018-01-31" version="1">MVSLTLFTLLALSGLSSVAQAAHIKPVHHPRAPIPAPVPVPVAAPVASPVTHVRQRRCKPRNNSNLEQKTEPYARISSTSARPSSSASHTSTHTSAAPAKTTTAPNPANSPSKGGSSNCFPALGFNPPANVPSSLDGWWCDDKTEYAFLGFSYEVSACQSKSQLNSEFADIRKRFNGRYVRLYGACDNNGFYDDVVEAAYANGLGVQALIWFGFDGGSQWEQRRDSLFATIHSNPKAKFVTRAVQFGSEPLLDGVLSPSDLAAQVRSAQDQLASLGIAVTVSDMQYSFQKDGGSGLKVLDAVDIFDAHMLPFFAGDATTAQASWPSIKSGIDNFWVPQANGRKIYLTENGWPSAVENDSQNPNSASAQASVSQEKAYFDMLDENCAYFKSVPGGGVGWFAHIYSDAQEGGYGILNDAGNLKFAFSPKTHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLI9</accession>
    <name>A0A2G8SLI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein MON2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MON2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SLI9"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF333">
        <property type="entry name" value="PROTEIN MON2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="5">
        <location>
            <begin position="202"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="6">
        <location>
            <begin position="1406"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="970"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1822" mass="198204" checksum="9DFBB9EB56289BAD" modified="2018-01-31" version="1">MSSLAFLVTELQSLASETRRKHPEVREAAEKSLAILRSSPEQATTTLASDGPQSDDLLRPVFMGCATKNAKVVAISLGSLQRLIALKAVPQSAVPLIVTTMGDCMNQGVDIQLRILQTLLSLITNFPAVHGQLLGDALLLCFRLQESRIAVVSSTAAATLRQLVMFVVDKVVDEDRREEVPDNARIETVLPNGTTAELGPSAYDAYAVFEDLCLLANSEQPRFLKLDSLRKTFALELIESVLTNYHDLFRKHTELLLLLRHHLCPLVHKSLSDRPNFPLTLRSTRVVFLLLKQFSSELKTESEVFLILLIRIVGAETSDADPTDAAQGHTIRPLWMRVLAMEIMRGLCSDAELIRNVWDRYDAEEGGSKVFTSLITALKRLVTERPALLGVGQQMFGVGVSTHPGSTADGAYGLDVGGVAGMVASAASATVTGVASMMTTEAGLSVQGSAMKLQCIDQLDKADSPPIPESYIYLLGVQCLVSLCEGFASFTAPLYNSIMVQKPRTAGEPLIRAPPALDIATLPQEDATTRQLRTVHCMVDSGWPALLAALSFLISTNLADELFVDVLASYQALTNVSGMLGLTTPRDAFFTSLARLAIPTRVVSSIESYVPVEPTTPRTTASAITESLGLPGANTQPPGFSERNMACLKVLVASALFLAGSLGESWFDILEALQNADYVLSVKGARGAGNKRNTIGPGAGSLPLSRSTSTSLPTSPPSHSGAPQPSSPIPRHPLLTDLDPDSLHHAIQRLFDASKNLEDEAFCDFVKALCKLSAAMIGMQSDSLDAVNESAEDLALSPSSSTLSAPATTEPAHRRRVSGIHLPRTLRSGDFGITRLGGVAMLNIHRLIYRSPAVAWDPITGHLLSVVRHQHAPPTIRVQAARVLDDVLVVVPRNVTSSGDLQPVVQRRVLDVLALQVVPEPAGSAITTTSIELRRMGLETLHQILQSSGHTLVVGWETIFEMLSSVCKPAPAPTATPATPTPSPSFQDLSKGRPPSLGYINEKGYTSLVKIAFQSLTLVCDSLSSLSPEHLRLCISTLGQFGRQADTNIALTAAESLLWGVSDSIQAKRRDDTKEPEYNALWMFLLLEVLGLCTDARPEVRVGAIQTLFRTLQLYGATLSLETWEECIWKVTFPLLDSITASIRRNSGVEPAEAQELAAPAGTAPDLQWDESKILALQSIGSIFQDFLTSKIMHLESFTEAWGVFVGHIQDSWRNDNRSITAPALRCLEKAIKALSIATELKPRTMEALEIAWHACDAMGNVVADPDPSSPGAKSPTAAISTTKPLTQESLVAFVDVIRCTRSMGRQLEDLEWTLERLTRLMTVLKGVLTYPSSPDFRPDIDALSPVQAVVMEAVDSIDLAGRGVISLVLRDLSEYATLPFLAAFDIQPAPSSGLPSATRVPRSTVNRVTYIALSKKTLPLLVDLFLRFKSDASIYADGTIETLFAAYSIPIKLKYECPAPSKFGKDQPLWKTATTSFLKIVKECGPQTRQLHHDIPPDRIEGIWRQVVDTFRGGILADCSAVENLPLDVQEAEENFDLSLVASLEIDVVPYLGEPSIPDYIISQLARVLHQGSRLRSTDDDLPPSPSSLPEFPLPQVAKRSSSDQFDKLERFGHDSIGVGTTSPGRFLPRERFSYWCFDLLFLICSDTSQDQIPSRRRIAALSLSSLLERCRMTLVGYVADESLRGNLPFPRAREEELLYVMRKLLALRLWPGTLWAALSDTPSLYCIEQPAMDQSLPPSTLIADAIKRSTKAHLFHFYPILCEIVSIPRKPPTVWVVRGPPSSTIGSEEPSSSSPAVELDARTLAKDCLKEVGRELGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLP1</accession>
    <name>A0A2G8SLP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLP1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLP1"/>
    <dbReference type="OrthoDB" id="2753410at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013681439" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="21806" checksum="D4687C06A08D803D" modified="2018-01-31" version="1">MYTLAVLSIAVLAGQTAATPVDVAGAAPLLAHFRRQGIATLDPGSIPAQCDSQCGSVINSINTCPDITCLCSDTVNKGLYNCFECGLSLEPDASLLSQAQKTLTQFENTCNQAGVPGVQLSSLTLTMPSGTVAAPSGTAGSGSTAVSIPVTSNLAGTTNTYVGTVNTVLPAPTTAVITVGSAATPSSSSSALNPLARNGAGVAGVSFASVAGVVGVAMVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMQ6</accession>
    <name>A0A2G8SMQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMQ6"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1236" mass="139293" checksum="25A53F8DCD06B09B" modified="2018-01-31" version="1">MAICDCDTCIQYTYVDIHGIRHPGRVLDASTIRTHKAKCLRRKKVHADGHDAPNTPVPPEPPTSAGNAIFLATLQAEATSNTQGLPVRNIDTAFPRLESPLPPSSSMPLGAVTYPGTVPDAADTRFGNGECGFEGTGLAGDDLDAGLSALGERFEELSSWESRLKVRSRLVPSYIRLVFKSKPHSLTDPVAELDVRYDGTAEFCILQEWLLASVDYLSALPPLGHKDADGQLQALHVKFDEELVRLEGVRSVSWTEELVEKGMLFQEEFMNAPVTVAKPPLMEFTETPTFLLAGLLMVTVLHTLSDVARPEAAYALCALKAVIFGLFVWSNTTNMLFPSQQALVDDTPVDIRTVLARLGVEPQITRYAACPKCFMTYPPDPSRKGDPYPCTCINSETDKGICGTSLVRRELENPENEGDPPYVVHKAIRPYPYRSMKDWLAHLFMKKAIEDIIDVSWDFVPPPGQPYGDIMHSPAIRQFLGPDQRTPFSVQANGEAHLVFSLFIDWFNPYGNKKAGKSHSIGVIYLVCLNLPPHLRYRPEFVYLAGVIPGPKEPQVHQLNYLLRPLVDELLELWHRGVCLKSTANRRGGRVVYAAIIPLVCDLPALRKAAGFSGHSASLFCSFCSLLKQDMSNVDRSTWPKRPDWKTHLFIAREWRDAGSEHERRAIFDSHGIRWSELYRLEYWDPTQFALVDMMHNLFLGELRHHCMEVFGVDVASEKRTPKNITLHTPQEQQAVLDKLFAALVAKSEKALLRFRTDYLSTVARFNNVKVNSTNPSKRDYVAHLLELNATAIRMPPPLSEPTTKFCLHSDQLDTSARHDIFTGEVLRQVQEDIANMTLPSWIERPPSNFGNAGHGKLKADEWRTVCSIPMILALVRLWGVSGASSEEQAVLENFVHLVVAVDLASRRSMSPCRAATFDKHMLEYVQGLRDLWNHRLVPNHHLSLHLRTCLQLFGPVQGWWAYPFERFNGLLQQTRTNNKPADMPLTFMRYFYMGANARWLMSTTPWPDDAVYQDMMMAFKRAFKDATRGTRVTDIPSFGPDFLKSETNPDYDRLKEKPLIPSVYDSLYSWVNASSPIDFQSAFAPHLDGRPRLPALGAFVPRISRSGVTYATSRATAGDSFITFLDRSRPSDSERSATSAGQIQDIFHHRRLEGTRTIVEPFVIVREYLPLEVKHQPHDPFRRFPGLQTELYYNDFKPIVRVIPLQDIVAHFASLVYTPPGINRPCIIARSLDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNG3</accession>
    <name>A0A2G8SNG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNG3"/>
    <dbReference type="OrthoDB" id="2737043at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043708">
        <property type="entry name" value="DUF5648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18885">
        <property type="entry name" value="DUF5648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013943392" description="DUF5648 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5648" evidence="2">
        <location>
            <begin position="42"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="182" mass="19998" checksum="8B8089F21CFE6EC5" modified="2018-01-31" version="1">MKLSTVAIALASLYMQASAAPTASDAPQPETVPNCGYPTVALLRAWSQSATDHFFTTNQTEMDAFLANGYVAQGIAAYILPSDTEAPTAVPLFRMYSAQYRDHYYTANATNRDVLLSQSSYVSDGIAGFVYPDQECGTVPFYRIYDHAIGDNFFTTDQAEIYDFVDQLGYTDRGVTAYVNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPM3</accession>
    <name>A0A2G8SPM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPM3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPM3"/>
    <dbReference type="OrthoDB" id="2670057at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="317"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="460" mass="49365" checksum="3DDE1C8030DA3E3E" modified="2018-01-31" version="1">MHISPLHRARQVQGITNGGFTVSEATGTGPLAFNSAAPTGGVTSAPPLVSDSSIVLTSSPSATASSSAPSGSSLDSATAASASSSSQIPLGTIIGASVGAFIGIVVLMYVLYAWYKRSTEKKLSVAGRRNAQGKAEQQRHQARQFQQLDDEEKPDRDVSPTSSNVREQLESDEKNFSMFKKSPSVRSAYTHKTGSDDGNHFDLPQLEFTKYHPNLAQELSLNVPQKPFAAAVRQDSGVSWDGETLGDDSFLSMHSARVESGTMSPTMVMAKMTPPATVSALHRWESAEVLHTGEEEAPPVPQSKNPFAEMVEEQRARGTNPFFNAQDMNRRSRAGRSRSNSRTSRTSRAQSLVRSDTLNTVNPFLDSHDAVPVSAIEMPAPNSRPRSPPLPTSASVQMLGSEHAMASLIAALDLSKEAVEERLRVVSMQGSVMSAYSNDDSDIATMREFPLPPTTGPHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQE3</accession>
    <name>A0A2G8SQE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQE3"/>
    <dbReference type="OrthoDB" id="2732257at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="297" mass="34370" checksum="7F73EC20C4AFDA82" modified="2018-01-31" version="1">MDAVRISDGRIVVLKRVPKSTYPFEEGLNRFLSMSDPQASDPHNHAVPIYDILQSPLDEDIVLLVMPYLIRIDELKFATVGEAVECFRQLFEGLQFLHHHHIAHLDIHKNNIMMDPTPVFSDIPHPTHSYKSYDFKHSISTRTRTSHPTKYFYIDFGFSWRLPSDDPSPRIGLGVGGDKSVPEYEDRQGRHDPYKVDVYCLGSTIRQYFMDKSYSLEFLRPIITEMVQQDPAQRPSVDKAFEQFEQLRASVSPWTLRSRMVYEDELPLGRLYRGCRHAIRTAFWMATGRPALPTPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQH9</accession>
    <name>A0A2G8SQH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQH9"/>
    <dbReference type="OrthoDB" id="2732257at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="22012" checksum="131B926FA4B78257" modified="2018-01-31" version="1">MNNIMMDPTPVLSDIPHPTHSYKSYDFKHSISPRTRTSHPTKYFFIDFGFSWRLPSDDPFPRVGLDVGADKSVPEYEDRQGRHDPFKVDIYCLGNTIRQYFMDKSHSLEFLRPIITEMVQQDPAQRPSIDKAFEQFEQLRASVSPWTLRSRMVYEDELPLGRLYRGCRHAVRTAFWMATGKPALPNPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR42</accession>
    <name>A0A2G8SR42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutathione hydrolase</fullName>
            <ecNumber evidence="13">2.3.2.2</ecNumber>
            <ecNumber evidence="13">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_01897</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="13"/>
    <dbReference type="EC" id="3.4.19.13" evidence="13"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR42"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR42"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000005">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="445"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="497"/>
            <end position="498"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL36235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="616" mass="66995" checksum="32D31B54C7F48F4B" modified="2018-01-31" version="1">MLKPGILGEPGSFKLTSQQAQRPARRSRWLYLAFLAFSSGYLLLENWEWNLAVSPIFPTPRCGQGSQRTQVPSGTNNPAYLVRAAHGAVASENVLCSEIGVNTMKAGGNAVDAIVSTTLCIGVANMFSSGIGGGGFMTVRIPPATPNATSEVFTVDFRETAPALSNRTMYVDDPLASRWGGLAVGVPGELRGLEEAHRRWGSLPWKTLVKPAADLAKGWPVPTELARRLQMFSQLMLNELDWQAVFAPEGRLLREGEIIRRTNLSRTLEAIAEQGPDAFYKGPIADALIDKIRATGGILTHQDLEDYKVHVSRALEGTYRGRKIYTPHAPTSGPVLQHMLNLVEHYDDLVKDGGTVLNVHRFVEAMKFGFAARTWIGDPAFHNNVSHIHEIPTKEYSDEIFSGITDETTHTPEYYNPVYDVVVDHGTSHSSVVDKNGMAVSLTTTVNLIFGSAVMDPVTGVILNDEMDDFSTPGTPNEFGLYPSPFNYPEPGKRPLSSTVPTIMEYEDGAFFLAIGGSGGSRIFPAIFQVLLNLDWGMDVSAAIEYGRLHDQLFPTMVDADDILPPTLLDGLRAKGHNITVSDTGRVASVIQAVVSQDSTLYAASDSRKNGIAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR51</accession>
    <name>A0A2G8SR51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR51"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR51"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="16"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="346"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1115"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1185"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1197"/>
            <end position="1215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1258" mass="136545" checksum="0E5F0B30AD0C3DD6" modified="2018-01-31" version="1">MADNVEVALSKIRPHTSSSLPHQKAPATLLRAIEATFLEQNTGPSATAYFAALLTTLDGALQSSRASGPALGDGDVLPAVLYLLAAVAPHVPHPVIRSNLSTIITLTSPLFPGLSPHAPPLRSQLALYGTVILALDRSYLDTQGLRQAFMTILRLAIDPRPKVRKKAAEVVKDVLSAPPPPTIKHPYAEKVAEWIKVALVEVSSGGLPKFKGKKAETECSEAAIHLLAFVRPVLPTLPSESLSSITSSLLLLPRLGNPYLSQSAYSILSDLLALSVENPTVNLHSHISELLKVILSSPPLRSDSALTAAWATVLGSTMIAYHHDNSEECAAELGKVWKAIWNLLDSSDTTTRKAATEALATLGQCFTTSLIKAAVKEKGTDDPKSTLGKIIAQTSKALDSLAYARAIPDVLSVVSSLIVHLRSRNGSRKNTTATEQLLLPLIVKVADLRVQKTFEHKEMADTTLGTAMRILGPAVLLRALPLNLEAVDRQAGREPRAFLLPLLAQPHPSPLGHFLAYFVPLTERMFDLQSTAESEGRQSEAKVWRVLIEQIWVGLPGYCWGTPDLKQSLTMQFSQLLSQLLYNQPELRPAVLRALRIMVDSNVTLASEDLEKIAKLPESVRMDPISTAEARANIDFIRSQAESWLAVLFNVFGSVGRDNQHIVGEVISSWIAIADANEVAQAYQKLVALFKQSLANAQAALASKGSPSDTMTVTTQDLLLLVLPYLSAEDATALFNMYLASDVLENKDNGVQKRGYKILARLVESGRVQADAAAVLQKLEGLVDGLAAAAKKDRIQLLVALIPVIPQDALHLIPSIIPEAVLGTKEPSEKARNAAFDLIVAMGRKMAGGGVVKRQMLEDMDEDGAGDATGSIEEYLTMVCGGLAGASAHMISATVTAVSRLVFEFKDDISSNMQSEIFTTLLVFLTSANREIVKSVLGFIKLAIHTMPADLMRPHLKDLVPALLKWSHDHKNHFKAKARHIFERMIRRFGWEDVYACAQEEDALKVLLNIKKRKDRAKRKRANAAEEEEDDAPRVRPAVGDAFEDVLYGSESEIEDSDDEDRPMQNPSAVKRKGKDAGARLRVDDDDPMDLLSGAASRVTTANAGKRRKPGQDAAHFKTDDDTGKMLIDESDDEAPGGTGGGNGGEDVEGNAYRENLTSVDGFTRGPNGKVKFNKDTKKRRRENEDMDGDVEMADGEGQKADKKTKRRAEPKFGHEFKAKKAGGDVKKGGVDPYAYMPLSQAAKKQNRSGRIGIAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR92</accession>
    <name>A0A2G8SR92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR92"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="340" mass="38786" checksum="11C0E7ABE43CA9B0" modified="2018-01-31" version="1">MKFTPKTNPELLTPIDYNEIRSLTATMHQQISSGTLDAPSWRLIRNAKLAGRMYAPLGTTMTLGDYVRVVRTFLEAFKLAEAPRTDPSSDGDAPPPAQVAREDMKIVQLGRDLKEYQDLLSSWGIKDDRIRRPLPRPIIVYRVVLRAIWSLVLLTVSLPGLFLWLPIFLTTFVAVHQFKRTGPVWDTYDEIAQYKLTYGLASGLAIWLLAMLATLPVAALTAVLVPAIMWLSLRWMEDAVAAFRALAALTRLLLIGKPALQAMRERREGLHERVMELAVRTLGLPAEPETYFAESGGREKGRVRGRWASKAKYFSVRRRRKRDWNETLRLYDQVDYPEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRA0</accession>
    <name>A0A2G8SRA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRA0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRA0"/>
    <dbReference type="OrthoDB" id="1645289at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17224" checksum="8F0658F90C5310C9" modified="2018-01-31" version="1">MVGWSMIQLDIKSTYLNGDLDEEIYMRQPPDLVKRFRSGIKQCFTITDSGEIAWLFGIEVVYNLNAGTVCIAQRTVIDAVVRALYLEGVKPATRLLTGVRMCMYIAVTSHPDIAYAVHRLMKYMANPGWAHWEALKRGLTGYANADWGTSDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRD9</accession>
    <name>A0A2G8SRD9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRD9"/>
    <dbReference type="OrthoDB" id="2754197at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553562" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52323" checksum="0B5ED3C3C6414476" modified="2018-01-31" version="1">MNGTVLNVDVLLLVFSLAHKQTKLELMSTCQVLYREGGKQLLKDMDGVWLGTEPRLESFLLFMDADGGSRMRYLHRLSLGINLTLSRPVAKRFKKMLNRLAPVSRLTDLSILHLEPLLSAHPFLSKAIAELTSIKAVNFYIVGKRSVKMLKSMQSELETVEFGGFDDQLIQSSKPDDPDLIMLLRPFSSGLRSLTVAGWCATVDPQDDAPQYPLLSDLTLDEPTSPTTWHYSRAFPNLKRLTIMTTGFVTAEERLDEFRETNVALLRRHGCWESLDWFEGPILELWLLGILCPVSKLNLHDECYPVTPDILRGALVPARATQLRISFYQFGLFLDEDFIRAFVEGCGATLKVLDLTIKISLGEYDEVGYDLDLGDVLDAITDMLRSFSTLESVTLGLYFEICHWRKDEELPGEVFAEDMDVDAMCAALHEAVPAASYVRFELQDHKTRGTATAKIGSEEKKERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRW7</accession>
    <name>A0A2G8SRW7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRW7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRW7"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="82"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="628" mass="71296" checksum="FDCA37DDFC8500B9" modified="2018-01-31" version="1">MDKERRRMPSSGKKRMLLDLDYDWDSLEGPTPVRKFKDSIHDYLYFGPTICAVMDTPQFQRLREIKQLGTSYYVWPGASHNRFEHCLGVAYLAQTLAMHLKTSQPSLGITQRDVQCVTIAGLCHDLGHGPWSHVWDSMFIPSILPDKKWCHEDASLMMFDALLEENGLELAEDDALFVKAMIMGNPSMCKKKEKPYLFQIVANKTNGLDVDKFDYIARDSHAIDQKGSLSFTRLINSSRVINDEICYDIKDANQIFELCHTRMSLHKRIYTHKTAKAIELMIVDALRLAEPVMNIVRRLEDPKKYLHLTDRIQSEIEASEDPRLKEAQAILHRIRIRDLYKPVDFKVFAWDQRADLKALFTPESVVKAFNAKHAEDPHLHTAEVDALAKEFNPDHVIIDVTERHHGMKNENPLDFMKFYSKRHPDRGIHANEDDISVTLPRAFGELQLRVYTRDPRFFGIAQHGYREILKGLQARGAAGDGLFSKDSANPVDEEVDLDEPVHPVTPPADVPRPSTPKSTAHHPRSMSRGHTRSLSRHASGVFVPPIGENQFTGVPPEFNPKESPGRKGRKREREKDADKVKGEGKDKDKVEKSEETLDLALSFGPPLETVGAPADGEGSTPPRKKTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS43</accession>
    <name>A0A2G8SS43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC1-like cysteine cluster associated with KDZ transposases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS43"/>
    <dbReference type="OrthoDB" id="2689725at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1044" mass="118025" checksum="FB2D5D3E17C6A718" modified="2018-01-31" version="1">MFDNIWYDMRQPVGSTTRQMGTHPKEHKVDWQEEIYSGTFGIAHPATAMTKSRRTGVSRHVNVAGPGFRLGASTPRSGKTQRCGIGQIAEEKVKATQRYKNLTAGLGRENLAALAAIRGENPEDGDNGADASQTDFLMDFAPETDDLGPGANDDGWEDVAEEESITHAIRDLVDAHTSVRVTKDTRTWAQRVRTMDDNWKPRIPLLTSAYLCWKYPKAMQDPPPSPTSEVEINVLDIFSSATSVQIPIVGDQSFAEALVHSGYLGTTPVFPTLAISLRTLELFRVIRLFKASFSVEAFAKMMCYMYYIPYRRQYRTALADTFDVYLTILSRVEAQVLGVLGRGDPDWRAVHSCPACSYEVEGEDPPTWARMIVLDGNNSLKRMAMTGGRMAGDVRVFDSNYYLSREFVNEYANEVRSRQAQTKPDLPDSDQEDDDDNAATPDHGGYPTDGKESNPCASHWKAAAADETKKMWGMFEETGIFASACRHAMILWLVDMVRSGELAKYPLAIVAKALEKISGKKLFGYDIGCAFGETVLYSRLKDAFQASGSRFCVNAFHGYSHSYDCQCQHHPNVIPGIGLEELETLERIFSASNQLAPVIRYASPYRRMSFIHAFFCQWDSDKYANIGLFLYNNYTQALDVIDKNTGAISAALRDLGFTAEQLADFDQEERTYFTNLRDEDEGNLWTITYVETLQALQKASEELLDTSKRLRTHAPRQDDGGVVLTFLAPQTGGTDYASDLSATRRLERSRRLLLERVDRLTAEAIAIEDDFNIDRWLPTDEQYMKTVEYINNRQYHRALGKLQRLVIQRLFELHKLNLSQTGYKARTYLAKNLQRRCKAIRNAVKRYNEAAQQMKPPRPALDWDRVSHYSFLEEFPLLQETQPDVLKKPWTRPEVRELIRASRRLTRAHEEIQNANREVRRMHTWIRDEELLFRNVSAKLQSEQSPLQGAFEEFCKHRRAANARNLAYIQHIYSLDHFSGVSGPGRHVNASECSDIPGAVVFAPEESETDNVLHELSEDAVFQEDDSAGGEVAAIIEYLAGLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSE9</accession>
    <name>A0A2G8SSE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSE9"/>
    <dbReference type="OrthoDB" id="2339190at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013916735" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26006" checksum="AD94459FCF97074D" modified="2018-01-31" version="1">MFTKTTLFKFALVPLAAATVLSDSASATPATQLEVRGDAPDPSGGGKWSNKANCECAWDKDHVPEIVKPCKETVWRVGERQKVVWEKKGDDDWKHDEPKKHNGTDGKDWGYGEDEDKDKDGKDWDDGKDHKRRPCKTRLFLRKGEAKPFVILAENFDVKAGFVEVTVPNVFHGEDYRVTLVLARDDRPELESCSDKFKIVKDEKYWHKDCKDECKPEDGKDKDGKDGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSH3</accession>
    <name>A0A2G8SSH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSH3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSH3"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="942"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1218" mass="129327" checksum="C7AC758EE8263658" modified="2018-01-31" version="1">MVPPSPGVDARQQPKSPARPARSSQRPAGRGHILSSPPRPSPPPPSTMPKPTLIQSILNRPSQSYHHPTQREYHSTRGELFRLAHATAKIIPGQYDDSGLDTSTPGDSDTETYHSSATFDRSSQRPSSKSRALSSHSGSDVSQSQRTTEPKRNPAHSIASTSSFVSAKNPDDNRSHTRKSSSNAHSYQSRSSSSRDPSTKGNEGDVEESTDEDEEGTDIFYTPRTSLASSSALSRVSLSAVAMLETPVLASALLPLHTKSKPVSVPAAPNDDTPPVSRTPSGSSLSSVASSTSGGDDSPSLFSDPSRGTSTRPTTAGSSERGAKHAASSVETITIASSASRPRTLSAGAKSTGSSSSARSGASTIRKHREEAGKLTYTDEDWAKDIRWLTPPKMPAAVNGRRTARTLPPDLPSLENDLSGRRRPGHPNPRAKGDRRSKRSRHSRGRMSALWEEDESEDGSTDFTSSEPSRSTTPIPETPPHSIPSSPLAKITTLPLSAEPQEENAPSESTHSESTPDARLERYARGNRRTYSTTSSLFRPNGSSNAHLPTHPLPNPVPSSTATPTPNGYTGLTLPHAGYSNAKGKQTAEGHVDLVRAGVAQSSMATIEVIRGVAATISNGVPLVANNSPSKPRRTLSFSLGRSFTFNFKGKKRESATPVHLRGGLPLPVAFTAHVAPPSFVPESHVLVQVHAVGLDTLDSLIVHDKAGMNGNGGGLTGGKGIGGGKAGFIPGRSFAGKVIECGWAVREEVCRRGEWVVGLLDVKKCGALTEFILVERHRVHRAPQPRPRTPAPLFQPRKRTHLRSASLPPNGQSYTSSPLAPAALTVEELALLPLCGVPAHRAIRTFADVLTPPLGTKSSDPPNKSDKRALILRGHDGAGALAVQMLHKRGVRVAVQIPESAMLDDEPSAAEDSTPAQIGNGNANGNGRKLSLDLVRPSPSKSDKDKDKGKAKESQKPKQTKQARTEGRLRAWGVEDIFVGEPLDVLRQLAEEGQSFDMVLDTVGGAAVWEAGQRLLTADWTAAASRSSLSLGRETSRNASLDVDLGADPAAMGANAESHTKLKRGRSTSRSRSVITHAQFTTLVGDTPHRPIPTAQDNLKGGLRSLRRATSTTSKSSPAVLTRGASKREKRLVGYAWVSVAADVDMEGEDVRDSLAAVVRMAESGWLRPLCVDTEGEPQEAGKVVLFEKAPEVFRRGIVGPLGVLADGGTCAVRIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STD9</accession>
    <name>A0A2G8STD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_00722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STD9"/>
    <dbReference type="STRING" id="1077348.A0A2G8STD9"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001818">
        <property type="entry name" value="GDNF-inducible zinc finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF49">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF49.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL37030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="436" mass="48093" checksum="90955909C47D7E07" modified="2018-01-31" version="1">MSSRNNDFLTGNYARLSLANFNQAPRRNPMRHESFQSFRDSLSPQSTSSESSATVPKSIAPPVPYAKTTTRAYGTKPAQLPLSVYELPTATFMWARWDPRGDSESESRIYVRYRSQTSDTDSNSTYSTSTYSRPHSPVSCTMGSSQSSPASTPPPLSYSRKRSSSAESDHEGSAPASPSDRLLKLPRVASDYGAPPNVPPTSASYSAGCANKEATKVYRPTSGAESDSSDVELRPATFFYPAHQSNSSRDGGAVVPRSIAPATAVVPAPPVQSQEKEEEEEEEEPEDMKNAWIKYTYPSPELFAGPEFQCVWPLQKHRDGTLEPCGYHSKKHLVKRHIESKHLQLRPCKCQYCGKGFSQKSNLDTHLNTHTGDAPHKCHYCDEHFKDPARRHRHMILVHGHHSSRTKKGRMCPGRTASSAKGSEHGIEDVATPPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STF5</accession>
    <name>A0A2G8STF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_00753</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STF5"/>
    <dbReference type="STRING" id="1077348.A0A2G8STF5"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="191"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="391"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL37061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="567" mass="61845" checksum="53D96C74EAD746A7" modified="2018-01-31" version="1">MSAVPGPSKPPATKNATRPRKRFVGSKSASPSKPGYTPTVASQIPQDILNDVQLNAAIKQLPSNYSFEVHKTIHHVRKNNATMVALQMPEGLQMFACTIADIIERFTNALTVIMGDVTYGACCIDDYTAVALGCDMLVHYGHSCLVPIDQTTIKTLYVFVEIAIDATHLVQTIRLNFPNDRQRLHESLLDSEEQNAKIPAGQPLVSGGHLRIEGPTSREGSPTEPPDSPQSSSPSDLPQELTRLAMVSTIQFVSALSHLKDELSIECPDTDIPKLPAGLLEAPVGESSDPYQSVGKPRLWTGKYDVSIPRSKPLSPGEILGCTAPQLNEVDALLYLGDGRFHLESIMIANPTVPAFRYDPYSKKLTRERYNHVEMRTIRDEAVQAARRSIAAYPRSPSHSQPQPQTESYLPSPPPTPDRNPVPHPQSPPTPSDDTPLWGVILGTLGRQGSFRQLRAITQQLAGAPRPIPYLPILLSELSPAKLALFGAHVAAFVQTSCPRLSIDWGHAFERPLLSPYETAVAVGKAAGWMKDGEGDVSERARMGGTYPMDFYSAGSPWAVARTKAMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STN6</accession>
    <name>A0A2G8STN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STN6"/>
    <dbReference type="STRING" id="1077348.A0A2G8STN6"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="309"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="369" mass="42372" checksum="744D8978BA9D290A" modified="2018-01-31" version="1">MSVGRSDVRRQHPGPRNPLPRGHLYGVSPPEILQSNPVAINEPTPVLKTPDFKHGTGWTFLWTLTLYNFHQMPFVKKIKSDAYFSRFQVKYRRRREGKTDYYARKRLVTQAKNKYNAPKYRLVVRFTNKEVIVQIVYARLQGDFVLTAARSKELSRYGINHGLTNWTAAYATGLLCARRALTKLGLADKYEGVAEPDGTLTLTEELDGEDDPRPFKCYLDVGLKRTSTGSRVFGALKGASDGGIFIPHNEKRFPGYDPESKELDAEVLKKYIFGGHVAEYMESLEEEDDERFKKQFSTYLADGVGSEDIEEIFTNAYAAIREDPTFKPTDKSKDWVTESKKYRTPKLTLEQRRERIQEKITAFRAENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUI0</accession>
    <name>A0A2G8SUI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUI0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUI0"/>
    <dbReference type="OrthoDB" id="3173670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20379" checksum="9C3179F4E54B768A" modified="2018-01-31" version="1">MGAYAPVAELRPVAFELLVIDIDHIASKPPRPPPKIFILPIKTHKHTVLINIPSTSTVDDIKAEVLDALQSGVVNAPVQLTEYAMDVDEDADDLEWKVPQVETIDDFELARQVKEKGRPTGLYEVLEVKSQLKNVLANWDPVFVQFKDPNGGLLPVKVSVPPVFPEEEEEPSLSAARKGKRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUS0</accession>
    <name>A0A2G8SUS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUS0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUS0"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="157"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="359" mass="40241" checksum="D76F3EFA04D79662" modified="2018-01-31" version="1">MIDLEGRLSDSFRSKTLKWLSGEYHGLNGTQYDVLDEVPTSLEFSRLVHISRPVLIRESVIPEDDDQRAWSKEWISGKMGDCEISVAVTPNGRADAVTGGLDGRLYFAEPHTQKMTMPSFLETLSSGTEAEPCRQNSAEVHYLQSQNGNLFTSRYFGLTGEDDPSEFEPLRDYVPSEVPWCSEALDRMPDAVNLWIGDEKSVTSIHSDPYENIYSVIRGAKHFTLLPPTEGWCLKERQYPHATYSRSGPSHELELIPSSSVSTPLVRWSSIADPTAPGALPSDAHPIHVTVKAGETLYLPAGWWHHVRQEGFTVAVNYWYDMEDRGMSWVWLNFFRGTEEPSLGNEEGAGAKAGERAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLB5</accession>
    <name>A0A2G8RLB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLB5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLB5"/>
    <dbReference type="OrthoDB" id="3255291at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="570" mass="61761" checksum="CFF261206FFB8B63" modified="2018-01-31" version="1">MSQQTYALTPPSTSAVASSYSQRIQDVRPSDRLTSTSSQQLQQQQVQGVDGALRSRQHTHGLARSAGEPQLHTDYRSSSASVSSSASAAAAAGERERTSSGGHERTLDRPNEAFSQAREMHLTFSPKIIRTPDHYSSPSNSRHASQEEDDGPPLPRTSGAHGNIYAPSRSSPSRPTPSRSNSISSHRQSTAPSAGVTSGQTTASSSLGLLTFTEEPQALLSPLVVGSTPPMETKSSPGRDVSRSQSYPFVRNPNPIVGFTGESEREGKMYPRTPRPNENLRSRLEPGEQGYHHSPDRDRSANVTPQPPIRTPPNLSPPTRTPPSRTSPSYNTRPSPDAGSHHARQISRSHTYPSVISHGVAISPPVIPPPVVPSPVGSPPSNSMSTSPHYGTSSSHYSSSSSQGQQYPSSSRSSYPSSSYSRTSPNANSTRSRAASPLRHNPLPRPPVVSPYAESLTRGGASSASAAAAAHQQSSFHNQTKRTVRRGYWNRRGDYLYVTDKDERFIVYAPPQLANPEELKQYPSPTDGWLDHHGDFVKYDPKVPELLDSLPVHGAAAKRPYQYFVQYTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLX5</accession>
    <name>A0A2G8RLX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_15204</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLX5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLX5"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="10">
        <location>
            <begin position="192"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="276" mass="30911" checksum="591C85AACEE2C520" modified="2018-01-31" version="1">MPNTAAFAAQEIVEAGQFDDAPGDDSTAASNPRRGHSFIDDEGLLEWSSGSSEDESEPDEFQEEEDALEAEAFQMLRAEDEDWEIAEGDFTKQYNRIRQHVAVRTGEAQGVASALNSKAAVASLPAVNRPHPPKPTSTQPSQQQQQHARDKTENQLQALSKYSSRLRNLDIRYDLGVGVNRKGPSATANMKDKSDRATSEQVLDPRTRIILFKMIGRGLIYEVNGCVSTGKEANVYHALTPEYKHLALKIYKTSILVFKDRDRYVSGEFRFRRGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM74</accession>
    <name>A0A2G8RM74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM74"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM74"/>
    <dbReference type="OrthoDB" id="2749729at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="392" mass="42002" checksum="D14B383D2CF67CC3" modified="2018-01-31" version="1">MATIQTFPITFIPADSATGIATSTVPAIGTGTVFTTSIASSVPSATSTGVVSSLPAGDSALLQNLLDGVHDLNIASAALLVGLVIASLTFGVMCTKAVTYLNGKNRGGALVIGMVVCMVLLNLVQFMAMVAAAYSAIIINFGNRESWLNSRATITIQVGLVGFAASFAHTFFAFRLHAVKRSMILTMAILLFTLLQFAFAIVTVAQMAQLGFANVLLLGADNIWAECATYSVQAGINVTIAAIAYVWVQKPYVQQKYGRTTFLEEFQYWTIKSLFGAFCISVFNAIQSAISDLEMLWLAGTFTIGNLYTLSVLLTLETDHPTGPSPTVINLARASRSDSRSFARRSSMTTLTDDTALWEDIVKAQTMKAARLSLPKETTYNRGYEKDVGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMU4</accession>
    <name>A0A2G8RMU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Delta(14)-sterol reductase ERG24</fullName>
            <ecNumber evidence="3">1.3.1.70</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">C-14 sterol reductase ERG24</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol C14-reductase ERG24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSI_15319</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.70" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMU4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMU4"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PIL22628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="435" mass="49466" checksum="AB0382D199E2FBB4" modified="2018-01-31" version="1">MASSSKAVSDLNPRTHHYEFLGPPGAFAITLGVPTMTYILYFACSEHTGGCPPSIDTAVVLDSLSKIEFWKSLWDTQAFIAYLTWYWFTVVAWFILPGDWIEGTVMRNGQKKKYKINAFSTMLLALGLVIGTIYREGPQPFTFIYEHWTGLITASLLMSVVQGIAVYAASFRSGALLALGGNSGNPIYDFYIGRELNPSIGSFDVKSFNELRPGLILWVLIDIGMICEQAVRRGGFDKVTDSMWLVFAFQSWYVLDGLYNEPAIFTTMDIITDGFGFMLAVGDLAWVPFVYSLQARYLVFNQIELGPIYTTLIIAANLAGYYIFRAANGEKNDFRNGRNPKNLEFMTTERGTKLLTSGWWGRSRHPNYMGDLLMALAWSLPTGFNTPITYFYVIYFAVLLIHRERRDDEACEKKYGKDWHKYKKLVPWRIIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMV5</accession>
    <name>A0A2G8RMV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_15526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMV5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMV5"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL22831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="320" mass="35492" checksum="5DEF3C49DC820993" modified="2018-01-31" version="1">MGHQMSSNLGNDALPEYDASGNLISPFYGYMPIQWVCYIFSVLFVLATAIHFGQAIRYRAWWLLPTVVLAGIGESIGWGGRLWSSFQPLARNPYMIQIVCTIVAPTPLIGAIFITFGRLSGYLGEQYSRVGARLYSRIFVTADIVALVVQSLGGGVAATTNDPKTGRLGSNIMLGGIVFQLFSLSLFCVLVAEYLVRYFKDKPVRPPLLTNNSSESLREQFPRPPLEPSARLLIIGLFLETLVLYIRSIYRTIELADGFHGRIIETQVYFNVLDGAMVVLAMYSLIAFHPARLLKKLDRKFAGGSSIAMMHKDVSYVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN20</accession>
    <name>A0A2G8RN20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN20"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="293" mass="32639" checksum="A78F5D2078303D1C" modified="2018-01-31" version="1">MVPLSHPYHRIVLGVELKNPKRLVGKTSTGYPSPVQIRGLFDLVYADQVVNQAKHVFGSYRDHDGGDDKWVPEVYLSIIVCGEWMTYLEITIRDIKKIESAKEEAELARQEEREGSTYDPAGAAHPVAKTRSQSKRTTTGRVQAAHSTAPKTTAGSGSTKLNTSGAQEKHSVDMEEWVKEDGASDEEEDEDGDGTWTVGEPGFSAAEELRKIFPPNKPFRPVELTSSSGWKALSLIARRMTDPDVSGDIFPVGAKAMDNCNFNGREEHKLIRSWAMRKNKQARKNVQEERKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN37</accession>
    <name>A0A2G8RN37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN37"/>
    <dbReference type="OrthoDB" id="2749557at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43591" checksum="F1277265A5BD26DB" modified="2018-01-31" version="1">MYDQQLPSLRLRMLPPEIVHDIVREAWLTIVDGDWALRWNFYDAISEVSRSFNLAMQTAALRAVAIRTPDDFKKYRCLVRRRFGLDPEAKDGDERAAPAAVGFFAHSELHIVLADWTCPGSGFQYRTDYALIPRYVPVCKYLQVLVKELPSNDQYTLPYKPLFQLLSQYPGTRHMSLHWTYTHSNRYILPSDPVPGVTYLRMREYPRCLCHNLAQPIHHNYPAGDARRAHSTECFSFYLPRLFPQLRHLHFDTPFFLKNISTPPSVDLLTIEVPPVHFTPDLGQFSSLVPWNIVSAFSYGFFRTVSPPTTDKGDGEPDPDAPPPPRKKIIINTGPNEPSGWSSVQAAAKTNGVDIVLRHVYPNPPPASPKESAKAKAKAKAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN46</accession>
    <name>A0A2G8RN46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN46"/>
    <dbReference type="OrthoDB" id="2734101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013956869" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="15177" checksum="7386B9BF4962CFCA" modified="2018-01-31" version="1">MKFALALVAFAASALAQHIEIGTPNNFAEVKAGSKITVEVNRPNSLTASTEVGIAIGLWPCGGPKGTSKCASTDVSQVLGNVVYTGSYKAVYDSAQPSKPPHQTFEVTVPTSFSKGEVSLGVAHLFLMGAGSEPVYEFVNTTLVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPV1</accession>
    <name>A0A2G8RPV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPV1"/>
    <dbReference type="OrthoDB" id="2758827at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58113">
        <property type="entry name" value="Apolipoprotein A-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="235" mass="25922" checksum="4F52FFE3B795818B" modified="2018-01-31" version="1">MSVSGVKPLRSPAPQLEGRPSYERDFGIGTHEVYADPVVVQREFQRVHDRVDDVKQDLKATRDALDEKISGLETRLTAKIDAQKVYMDDKFEQQEEKFQRRMSQLATNLDTALDVHSEKVAARFEEMDKKIDDLKQMIQQLLAQGGAPPTPLPSASSQVPLPANPPDVVVHAAPAPVAGPSNPPRHHSPSLSSLGTELNGSHHSNRGQLRGLLYSIKRKVSKGLGILSKDDDLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQH6</accession>
    <name>A0A2G8RQH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQH6"/>
    <dbReference type="OrthoDB" id="3066311at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="469" mass="52111" checksum="C9C76D740659F7E7" modified="2018-01-31" version="1">MAPTLSFLQSSPTPPSLPTAVPPPSQDFVMQQMPNVFVHPPDEELEYNPPWCYFDATQAVKDNLSTHPDMEALDVALSFCQQTDNRAPTFRRTFSNESQDTVVMPRRGSLLNLKFRAQDLEMDMELEPDGQTDIRSRGARRYDDDVVEVVKFRRGESVADLGPEQTIKIKRTNTFRARATQALRSIKNVGKANRDRRATVSAPQPLSPAESQSQMDDQSRHHLQGTTLPTRHSYQDSLISRPASPSISRRRSLNISQLFTSFKDNKENQTSRPASPADELMAPTSPTLVDSDSSPSVRPMSPTDSPTPRRFLPSDFQDYTPPTPKSPTPTPRPPAPEPTSKVEKRRSFVRRISVLELQKLFTGGHSSSSAYSLEPTPLPDDEDVFTPSRSHPISVDSAAILSASSSRISQGSSSRHSNTSSEALSARQSWSSQLTGAMEEGEAADMEMRLDSLHFDSLHFDPDEIMSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQM6</accession>
    <name>A0A2G8RQM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQM6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQM6"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="117"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="367" mass="42149" checksum="5B9ACB48307733DF" modified="2018-01-31" version="1">MTWLRFALDKALSFVGKHALILALILAFLPFLIILRRRLHTHPHSCEDDTVPEASISSLRRKHRKARTQLSPSSISGGGDHPQALEQLQPLADFESETDEDESRDQMAKRTKQPYEAFLVLDVEGTCVQGSGFGYPNEIIEWPVCLLRWKDKDMKGNAQELEIVAEFRSYVRPTWRPQLSDFCRTLTGITQAQVDAAPIFPEVLQDFRKFLEKHKLLDAGGHRLQRFCFCSDGPYDIRDFVVKQCFISKIPVPTWLTWDIIDVRRTVGAWHDSSTASGAAERRQAQAGVLPLPKRVSFSISRQLHALGLEPFEGRQHSGIHDARNICRLLIELARRGWRLEPNTRINPNRRWPWMGKRGNVLEEYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR24</accession>
    <name>A0A2G8RR24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_13710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR24"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR24"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="54"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="202"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL23959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31512" checksum="B1193E87B23D82D3" modified="2018-01-31" version="1">MSRPELVAPPEIYYGDIEAKKYTNNSRIQQIQADMTYRALELLNLPPDEPAFLLDIGCGSGLSGEILDEEGHMWVGVDIAPSMLEVALEREVEGDLFLQDIGQGFGFRPGSFDGAISISVLQWLLNAETSHPTSSPPHRLTRFFITLHAALKNPSRAILQFYPTSDDQIQLITSIAQKAGFGGGVVVDYPNSKKARKVFLCLFVGGGGGAQQVPKGLESEVEDEGKVQFEKRRERLKSRSGGKRKNIKDKDWILKKKELYRQRGKEGVPNDSKYTGRKRKAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR43</accession>
    <name>A0A2G8RR43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR43"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR43"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052276">
        <property type="entry name" value="Diphthamide-biosynth_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240">
        <property type="entry name" value="DNAJ DOMAIN (PROKARYOTIC HEAT SHOCK PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44240:SF10">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="10"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="579" mass="65880" checksum="2EAB29CBEAAA5B68" modified="2018-01-31" version="1">MAHRHANVAEAYAVLGLDQDASLEAVKSAYKQLALKTHPDKNPGDEDATAQFQKVSQAYNVLVKHLDRSSAPSHTHSHSHYHPFGYEEGDYYDDDDDDDYDYDDDFYDDYEDAFEDMEFYRFLFEELLRGRASRFAHAQYQREHHHHHHHHHHFRRPPSPPESQEQYTARLRKQVEEQEKAAERRAREEANRRANQEMERELERREAQKRQRVKASAKKASAEASRKTAEEKARAQQEQMQTLRSQIFAAARKGDAATVRKGVWEQNVDAAGGEMLKGYDASVKSRPTDTQETLMHIAARNGDLDLVECLGKYSADPEERDCEDMTAFHVALRSGHAKIINYFFENYPPNGGEYEDIYRSPDSKSNLYLALDTKEPEMVWLVLDKNICTEEERDAAWEIVKGKTFKSSISSADKYTEFVNLFGTYGGYSLKRPELKSESSPIPEFANLSMESSHANGFGLPQQNGNRRPRPTVQVDSHRSHTASPVENPQTPMSAASTNSPRGYRGQPNRRGSFRPHQSFQGQQAAPSSPVDQGTYQQDGAPGQQQFSGYRGRGRGRGQYRGRARGRGRGQPPVYSTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRC9</accession>
    <name>A0A2G8RRC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRC9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRC9"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="49"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="274" mass="30899" checksum="5F774248C805B118" modified="2018-01-31" version="1">MSSKVHAVAQAGFGNGTNELYDRARPSYQSNALAHIRQSIKAPSPLNVVEIGSGTGLFTRALLAHPDWANSVKELHAIEPSAGMRDVFAKGTTDTRASVHAGTFDSTSVEDGWADLIVIAQAFHWCPDYNKASIEFARVLKPGGIVALIWNLEDRDRATWVAQNRDIYERFESGSPQFRLGLWRATWTTPGYQANFQPAEENVWDYVLPGTRDIVIDRACSKSYIALLEPEARQKVIDDLDEVMKHKENFTWIDEDKGIFEYPYQTFLYIARKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRP1</accession>
    <name>A0A2G8RRP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRP1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRP1"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="285" mass="30799" checksum="41628B0F324D7B49" modified="2018-01-31" version="1">MAPTATDPSNGNIPISNTGVAVGKLPRPPQFTSKEQERKWLKFRLAQAFRLFGKYGYDEGVAGHITVRDPIRTDCFWVNPFGKHFSLVQPEDLILVDHHGAVQAAESGPNTLLNKAAFMIHSAIHTARPDVHCAAHSHSVYGRAFSTLGKQLDMITQDSCAFYQDHGVYSQYGGVVLDEEEGDHIVKALGNKKAVILQNHGILVATNSIEATVHFFIALEKSCQVQLLADAAAAGTGGKTAKIGDADAKITYNVVGGLPGGWFSGLPHFQAMEAQEGVLFDFESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSF7</accession>
    <name>A0A2G8RSF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSF7"/>
    <dbReference type="OrthoDB" id="2984747at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="469" mass="50956" checksum="04C90C9D8B08CC4A" modified="2018-01-31" version="1">MFEEVCLVCGRPVLADGRAYCGDECESQDITSPSISTTSSAHASPFLRSSHNTPSHLAEVPALLPSALGQSFGARKPSHRVRHSESSSSNSSTSWSPLDDEHEEDSASLAICGANTDDEYYAVNPDYTDPSKLSPGYAHHASSLAYARRPSSTNHRSMLPSLHRRTSSVSAMTASTGASRSIHHDASTEDDFSDAPSAPATSSSVHSDRRRGRKSADLPQPPSDEDERGQDPETVTNKRRRNRASLPAYFSLLVSTATTTRSHKGPSALSMLSRSLQNNSASPPTPRLAHPIVDTTTAFAIAPSTRVFKEHASTADAAPRGRSRRRDPDGRSSSSRRSPSRSPRPRAHPHQSAQARARLDSMEKVADWVAHSPVVAAGVRAARQLTQRRNSSPPPLPKFEKMDLRDSGADFEYDEDNAPPTHEMPKRGRRRADELDEEPLDAHRKAPGYGSGRSGLIDRERGRTAAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSY7</accession>
    <name>A0A2G8RSY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSY7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSY7"/>
    <dbReference type="OrthoDB" id="2750926at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="21"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="346" mass="37369" checksum="401C21C9ACD02EEC" modified="2018-01-31" version="1">MSSQDGADIVALYKSIFVGNCCGIGGSVFLIYEYLISIGDGINLFATSKITGASILYLTNIIIPFVTNAMALIGFTRMSDKVRPIFCLRNYIPWATFSALRAYALSEHLPLAILTLFFAMVSFSVNLVQYGFGLTGLNDPTFGCSSAINLPQGLSKKLSRLTIVSRTCLISSDAIVIAVTWYTMPRKHHVAAVEDTPTFAGILLRNGTVYFGSLLILNALHLTFTLVAIDLAFENVSYMTMFTEPVTAVLVSRFLLDLQAANRKTLRLDSQDLSQEETSQGVPTGSLIFNRVVGSLGSSILPGSSSFDDTDDTDPDEGPFALSCDPEVEKGKERSSETGSEDAGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT91</accession>
    <name>A0A2G8RT91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT91"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT91"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="547"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="839"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="849"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115214" checksum="82A3572A5566BD4A" modified="2018-01-31" version="1">MDFEGDKPWISSDEDAEGSDDYETTSDSGSGEDDYEDGYAVGRLSSRGLPDRGEGPSTRPLEADAEAEDARVEAAIEGDFDRLIQNIRGADDGESAGMLSRMWDINLEEREAEFRDDLRMASGVGRSKKKRGRRHGPVLSQQVRALIGEGNQAYIDTNIPETIRIMQEVIRIEPRAAPAWSVLAQCYDDMDEKKKALQLRIMAAHLNHDADEWADLARQSRSLEYYQQALYCYGKIYSLDPTNVSALWDRASLAKEINDLKTARSTMLAMLKRLPHSLPVLDELRPILIELSDLALCASLFQGAFAHHMVAFPSGRGVDPESGADVPGGGFGLMHLLVLADLYNTLGEYGKAAETIRKGCRWLQGRAVQKFWDACEDDREWDVPLESGGPGMVRGGEGEMPPGCYPLDVNARHRLAIARIRGGDVDEGKMHAKVILAQDVAEYAPLFSEIADAYFEREMYSEAGHIYEMLGGDAGTSSMHVLLQAGVCRRMVGDLKEAAEVYEHVIQADPANNDAKMKLAEILEILNEPRKALELVLQVIDSRKRRAGQREGTFDPSDPSSASLFEEGKVRGTPAKGKGGSSKSANKLSPTQLRELEAQKEREAQQSWHRVQELWPRMLANEDEATREWLVEAEKLVESFRETRALFLTSRHRGFRGMFPRSSRKQTSEASEDSMASRLQLELGRDTLTRKAAKSESVNNFRAISFEDWLRLFMHYAFLLTRRGQYDLGDEVLRHLLFSNAFQTRSSQDSIRLGIITCAIYADQFQTVVEQARKLINGHQFNNEPIRVLISSLGSGLRATDAFLASTLSKHLLRETRLADAAVNNPDALRFNTSQRRYGLPGSVKADPDDAPDEDEDVESSAVADLEKSKLPTKPNPLNVAVYGQILLAARSYQSALFYLLQAYDYAPEDPLVCLSLAIASVGRAMQRQSDNRHHLITQGIAFLTKYRELRGETAEGLDEVEYNFGRVFQQLGLHSLAMRHYERVLQAAEARSMVNDDIGLAQEAAYNLSLIYVTTGATPLAQALYRRWLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTP8</accession>
    <name>A0A2G8RTP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aip3p/Bud6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTP8"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aip3p/Bud6 N-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="92" mass="10453" checksum="2C136AE9F2D3BBB1" modified="2018-01-31" version="1">MVHKSEVQPTHDFLCFSDLYDVPVTLRTVLEGLLAEYPSPEVLERYMPRIRTALVKLLRGLQAKQAPYWASVSRSRDNTRYSTVPGTCIRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUE5</accession>
    <name>A0A2G8RUE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSI_12845</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RUE5"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="19">
        <location>
            <begin position="97"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="20">
        <location>
            <begin position="191"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="21">
        <location>
            <begin position="777"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="18">
        <location>
            <begin position="1107"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PIL24958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1576" mass="176449" checksum="D235A652323BE040" modified="2018-01-31" version="1">MALPAKKTKAPVPSVSIPKHDPANLNGDAPKTPKTPADEAIDFFESVTIQARQPIRVYELRLDPDGGLNKDRSVEYLSLPSLHHIHYMRLPPAYTPTNFPLDGGRFERDRFAERRLPTDFSSPIQIDLPISHAGAFVYWVEYDGDTAGSRVKGREGYFNIDPILRTKTRTPIVSGGAIAVDGPTVMSDYVNLPLDGLSVLTLVSKWMGSTSGWREYFAESSARGYNMIHWTPLQERGESDSPYSIRNQLVYEPSMFSDPKDLGSDGGKTKLEEILKVAREEYGLLSLTDVVLNHTANDSPWLLEHPEAGYSPSNTPHLAPALELDTALLEFSTELEVRGLPTTVASEQDIAQIVGGLESYVKERNLWQYYVLDVKQERNTIKAALDKHDVVAWTRGDIANMTVVELAHAVRDSGLIEGYQKLEKRFGTHVPGPVAAGFVKAAFVNLADNDALADAWIRVVDVLNVPLYEEWNEDTKVALDHVRNRVKYTRLEEHGPKLGPITPANPLVEPYFTRLKDTEPEVYSVANNGWIWNADPLANFALWPSKAYLRREVIVWGDCVKLRYGDGPSSNPWLWEYITKYVTDLAATFDGFRIDNCHSTPLHVGVALLDAARGVNPNLYVCAELFTGNEEMDTMFVSRLGINSLIREAGNAWDPKELSRLLYRHGLGKPLGSMDGACMTSKGELPPPTGKGPTRDCLVVPHNGSVPHALFFDLTHDNESYLHKRSAEDALSTGALITFSFSAIGSVKGFDDLYPKLLNLVQEKRKYEVTNVDENSGIAKAKRIFNALHTEFSLEGYEEGHVHQENDYIVLHRVQPHTQKGYILVAHCAFQKGSKERGFITPIKLRSTKAKFLYGAQIDFSSYEVAADPSTLRGMPGKLVEIPQVAVAEGSDAEGPYSEIVVPDHFPPGSIMLFETQMQGLDSSLDEFCSSGAEEAFGDLNLVDLNVVLFRAEGEERDATSGEIGSYNVPGIGNLVYCGLEGWMHPLRHIMRYNDLGHPLCGHLREGAWAFDYVHNRLFKQVDVFPNLTRPAEWFKERFDRVKESVPPFLRPKYFAIIISEAYKVARRAAIEQCSNFVSTGHEFTHNLALCAVQMYGQIKSASLDPGKHTPSVAAGLPHFASGWARCWGRDVFISLRGLFLTTGNFEGARAHILAFASVLKHGLIPNLLDSLWNPRYNSRDSPWWMLQNIQDYATSAPDGLAILGESIKRRFPQDDTWVPWDDPRAYAYTSTVAEVVQEILQRHASGIVFREHNAGANLDMQMRDEGFDIDIKVDWETGLILGGNRFNCGTWMDKMGESQRAGNKGLPGTPRDGAPVEITGLLKSTLRWLSELSAAGKFPFKGVEAEINGEKRLITYKEWSDLIQASFEKCYYVPLDPSKDSKYRINSKMVNRRGIYKDVYGTPAEREWADYQFRSNFPIAMTVAPELFDAEHALGALKLADEVLRGPLGMKTLDPVDFQYHPYYDNANDGTDMAVAKGWNYHQGPEWGWPLGYFLRAYLYFDTQAGAGKQDPTVTLHHLHRILLKPREYIQKDPWAGLPELTNKDGEYCRDSCNTQAWSSSTLLDFLEDVHKMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUU5</accession>
    <name>A0A2G8RUU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUU5"/>
    <dbReference type="OrthoDB" id="2765866at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="603" mass="64719" checksum="1F248E583D5414DC" modified="2018-01-31" version="1">MTGTTTQEAGQFAGNTPFLGHNIQGHSVSVKLVREVPAEVLRTSVTHFGTRGLFGKPILRTSQHDHDNLRRKKWRIAQSLKRNTRKVKANPKGGGYHGASGDNAWIPPPNSNFPGPVNATARRRPPTPIPLPPLPPPPPFPSPPPNIVDLSSLPTHATQTRSQIRSASAYEESSCTATVPTSASGGTLPTFADYHSHILSPANHFGNAAASPHPSSHYAAPASEGDMYLDTRFCPLVSTLTEHSAIEAPLTTEPANVHWGVNASSVREPAFIWQASSGEHITTWTEQNPKVPHDGLDIDASLNIRITEINSAQRDTLDEKLLYWLPSSRLGAARSERPISTSVGREGESNQVYPSIPGGLHAAGETQSIWYGYPATSAAYAHASYTASISPRSPIAPSPPGDVSPGRNCMPLVNQYSTPLWSSSRREREDWGTSLPPNACSTYYTSPSLASVFNQYPGSDASRPVLTSPSDEFVSDLADRYTGGSATRYTPLPNQPIGSCGLISTSMSAPQDVWQILPELRLAHAVDTNVNINTNTSCTYPQPVTSGTDYAQAFDGNLSSGHPSWLSPIPHMSHSLAASGRTQRDNGARSFCFCATRCTPSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUV1</accession>
    <name>A0A2G8RUV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUV1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUV1"/>
    <dbReference type="OrthoDB" id="10260614at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="153"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL25290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="393" mass="43581" checksum="58A5C603335DF06F" modified="2018-01-31" version="1">MWPFLILHVVDQHWGQFVVAGTVGAITLGAHLTNYELFKWWAHLRTSPHGGYDKNRPPTSEELARVKYFTFGRRLQSGLAHLKVSVEQLPETMKAMITWSYVQVFQPILNATEGKRMCWAIGAANVVVWMAWRVPRWGPFMMRSFAHNPLSGRSYTLFTSMFSHEGFFHLLFNCMALASFGSAASQYLITQFKKVELEHGALSEPSPKWHLLALFVSAGLFSGLVSHIGHARWQYPRLIARMRNATTTPATTSFAASLKAGASSAIPQAEATAVTASKSAASEGMSSLGSSGAVYALFAVTALGFPDAEITFVIPPYFPINIQSGFFALVAIDTIGVLRGWKYLDHFAHLGGALFGAFWYKYGADIWYSVRMWDLPAAFYLHGHGPMLKQKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV31</accession>
    <name>A0A2G8RV31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_13260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV31"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV31"/>
    <dbReference type="OrthoDB" id="17644at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL25370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="588" mass="66495" checksum="AE18F493D2B003C5" modified="2018-01-31" version="1">MSVIFAAAQTLVKASRAKDVQLLQSEDGIKALNKLANDYVNFCKECCMYASRDISRPEPLQFDAEHYRKLYTCFSLFSVLYLPEPGFEDVPVGDELMEWLNTHFIEPSTQEGDDLSSLAQQLSPLLTDHPRLNNFNAERDFAVASRRWKGKVKTLRIELDRVPESEREDGFENWWDRFSDIVGILEGREDVIKKVCLELGADWKEVCAAWGIFVDTRLRRQDLPEVVSQILDEMPSDPTDLEDVVHSSLFLGRPAQALSEAARLDVWLAAHFADLMEPMELIDSEPDDSELTLRQQYVLAYAEYLRSDPALWRITVDYMYSCGDIGREMGDQVLMRVPLRLKPLKDADNGEEAARIRSGQLAGALKDIHETCFEYKREEIRRLVCKVAAQTFIQEKEYGLAISYITSAEDWPGLGRVVDLVLEEYVLVANIAPSLHNLPLDSAARSSVPAVFQHRLMFAVRFAEFHQRRASGDLAGAASDLLSMFREETAPKSWWAVLLCDAVELLQYNETMLFPSSDACVLIQRLEEIQIRVGQGAGDDYLSVLARIANGGEKHAMQRLQTVRLALARYYARCGAIGVGGRPSGWSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV63</accession>
    <name>A0A2G8RV63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV63"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV63"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013424410" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="35"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="381" mass="40308" checksum="D9011FDCA48F2115" modified="2018-01-31" version="1">MVPLRNLALASVLFCITSAVPTLGSFTHRGVDSTQPSVVLDNATVIGFTNETTGTIQYLGIPFAQPPVGDLRLRLPQPVAPYAGTIDATTFGNQCFQLPGSATNLTVPQDEDCLNVNVIVPANLTAGSGKLPVVVWIYGGGFTGGSNTAEPVQNVVARSVELGHPIVAVSANYRLSAFGFLGGKEMKEAGVTNLGLHDQRETFRWVQKYISAFGGDPTQVTIWGESAGAISVAAHMLHNDGDTEGLFRAAFMQSGAPVPTGDVDNALCQSTFDQIVSGTGCAGSDDPIACLRNVSVDVFFEALNTSAAQSTYFTNSPWLPRADGAFLAQPPQRQLLAGKIADVPFVSGNDLDEGTLFSFTTLNVTTDDEFLGYVIRKNLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVL1</accession>
    <name>A0A2G8RVL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000047">
        <property type="protein sequence ID" value="PIL25555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVL1"/>
    <dbReference type="OrthoDB" id="2758311at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="526" mass="58945" checksum="7D47BB50BBDAD25A" modified="2018-01-31" version="1">MQPPQTTAPWVLELELIDGRIRVVHEEWAKKAMEDRRPSVVIATCPKCSYYVGAPVMCKGQSNPTKKGFWFEKCLNNEQPAPDSCDYFKWRSDIPRGKATDRRESKKVECPGLLCRQSGKPNPINVECTFGVRRGKSTRKQAKEPVVDTLSDVGELTSDSEDPSTPKTPSKRPPAKRASYATPTGPAYQARISEIDAERRLFEEERVKRIRQEHAKSQVQTVTLRWWTVDGGDPEVVEIIVENASAFHPKDIPQLVEDYRCGEERFQYYDSKKGLWYMGSKGSAPRDINKLAEDDFCYRSLGVTSGKGMPGISKKRPATEELSAPVTPRRPIPPFGDFPITPESRDRRAVSPAATTPPGSGSSAFPEDEELAFVSNPSPSDPSIMALTLDWTACTSPEESFAPIPALFPPEPGCAATPKDILAAVPLDLSTAPRGRHGWPWKYVCDMADGLAAMRKLQDSYPSLSTAEAFESVFKEKFKSSTFSEQIRAWRNAGEVPGERARWINMGRDEHGEWTKFMIRWRPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVM5</accession>
    <name>A0A2G8RVM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000048">
        <property type="protein sequence ID" value="PIL25534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVM5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVM5"/>
    <dbReference type="OrthoDB" id="2755385at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="495" mass="51033" checksum="F15E7618ABFE4415" modified="2018-01-31" version="1">MSSPSLIDDTNPAVQYAPGWIWDQLVNEVDHTRHGAATAGLTASLGFYGSGVQVVGTLEPTDHYGQPTTTYKIDGAQEGTYNAPFTASGDTRFNVTFFSKLDLTLDNHEIVITNVNGTSPNTFWLDYFLIYTQTPSSGSTTTTSTSTSVTPFSTHTSTVVSTVHSTSTTSTTTSSSTTVVLTALASPLSLSTTSSSSSSSSSSSSSTSTDPTTHSFSDTATTASQSNTPTTSSATGASPASGSSQSSAHSNTGKIVGGVVGGVAFLALLAILFLCLRRSRRAQDDIEPFALETRERSSSSGTLLGAGRSPAAAKVNKIPELSLASSTAATSPTSRSYAPTASDVSAQPSEFGAPIAALAMGGASASAAAGGPSRPSPSSAQHGLSPADLKLQESLYGPSSASARSTPRLGRIPGSAGASDYAPSSATRVPADAEASRARWYAPAQEQSRAQSLLSLLSSRGRRRQDHQRQDRDQDQDSGLRLYNEPALPPPYTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW61</accession>
    <name>A0A2G8RW61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_11499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW61"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW61"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="426"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="10">
        <location>
            <begin position="489"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="535"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="655"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="568"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="655"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL25749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="829" mass="90112" checksum="AFA48DD140778FF8" modified="2018-01-31" version="1">MPSILNLKFKGNKSFVPFSNLSDADSLTKTWKVCTKVASFLEQGQRLENLSWRLWHLQNLMVDTDNAKSKRDFKKLSKCMSDKLDKEKGRSIEELQAPDFKRNHSTELLQQRALEKEREREASQNGRPGTIHRMQFTFSVDQPASVVATAVSTKKPDMRPSSEFKDIAKRGRPATRSTTAAEESAAARDCSTLDDKDQPLTHRGRKLAAAKADPNKDELYQAAALRFPSLFSNDFGPSALLYPTPTVTNAMTYGEGVGSTNNNSDGFSIVRPTIELPLDELLNADSPGGWSSGFHHQETRQPDHIDSQEDVEMKVATNDTPFPHHAPRAEPAHEEENLLKSAALRNVSALSAMEDVVPRTITPSRIGPNSGPGANTTTTTTTGKRPSLSVRTQSVSTRSTGPSATPVNTSQQNNSSNSAPGGVKAECSNCGATHTPLWRRGLNDELNCNACGLYCKLHKRPRPKSMRNNHGEGRAQAAPRQESQEVVAQCYNCHTTATPLWRKDDEGKTVCNACGLYYKLHGSARPISMKSDVIRKRARHDARRGAGNGSSETPPSASPGASRRPSPNAESTPTLAPDSSTQVTYGGGEVSSTNSAGNNLDYRGSLQSELLGALGSAELHYGHQLYSQSSYFPGPYHPDYISHTYSIPSDALPFSSGDTSDADSASECRSSKRRRMSNDSASEPPSSAVSFSSYADSFTSTSSSASHSQRSSVDFPYTPYSSGSFNMLRGGPWHPPMMPPGDGSPSLSFVHPPMLPSAGADDSPMFFHPPMIQHQDDTDALFAAYLHPPMLPPDDSPPMSSLQLHPPMISGEWKMSGHAEYDSNAMVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWN3</accession>
    <name>A0A2G8RWN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_11682</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWN3"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09401">
        <property type="entry name" value="LIM_TLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000001">
        <property type="entry name" value="Cysteine and glycine-rich protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN CRIP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46074:SF5">
        <property type="entry name" value="LIM DOMAIN-CONTAINING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="208"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="281" mass="29349" checksum="4524C7DD53EEB99B" modified="2018-01-31" version="1">MTSSKICHVKLFGTRDLRHGNLPHRDDMIHSHSTGDSVGRAASPPPSPTRLVSTTGLTQPQPLRAHQTGGASVSGGSSKSPPPLLRPNRTVSPAKGMSSLQALDDLVEEFEAAEVASHMEGQDGGTTNAAGLILQNRDVRGNETNGAGGARAVVLPLNGYPRTTSPRTIPVPLASTMTGTRYGAALGGPAATPLVPAMTGRQWGAGTPKCPRCGKSVFFAEQVKAVGKTWHKACLRCMECGKTLDSGQLVDKDNEPFCRRCYGKKFGPQGSGYALLGKPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX26</accession>
    <name>A0A2G8RX26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX26"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX26"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013788951" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="307" mass="31599" checksum="2861819BF50A40B1" modified="2018-01-31" version="1">MHSWSRLIGAVSFLLFPVAFACNVVITNGDGWAVAQIRAQRDSLIHAGFDVILSAPPQDLSSTGSDSAPPKPLTRPCQFNTCSTGSPAEGFNASDRSTQSDTVYGPLSPKLFHSPPDFVISGPNVGNVLGRGTIYSGTVGAAAEAVKEGIPAAAFAAGTAAKVSYTTLTTAPRSPDTLSAHLYAELTTNFTCTLVDPAACPILPAGVTLKINYSPTTFSASGGAIGNCARASDFKWVLTRMQASAGAVDVATCGSRRLPVEETVVDAGCYATVAVVNATTTLDVGADAQEHVLNRLAPSGLLSCFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXE2</accession>
    <name>A0A2G8RXE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_11742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXE2"/>
    <dbReference type="SMR" id="A0A2G8RXE2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXE2"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="849"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="432"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="816"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="909" mass="98300" checksum="922E3A2F4D7A8FE0" modified="2018-01-31" version="1">MSFPFRHQPVKAIYTIGQAVYLMVTLPAALILYALPAARPRRSWPLKRVILGRIARAWIDTTWKTSLDPPPPLPQSERDTNSLGFVWVEPTPELVVGEIAEIAKQNEVEPERVGGFWYGPRNSNDRVGQWASPGEKVVYHLHGGGHVTGTANPKGGFMPIHQGYLDHLGANFRVFSLEYRLSSAAPFKSANPFPASLIDTIAGYRYLVEDLAFEPHHIIISGDSAGGGIAFNLARYIATANLPSLPTPGGLILLSPAMDWAQTHVGAESSTMRNARDCIVGYVFECGYARRALVGNLPEELAATSAWISPGALNAEWHPGMFSGFPRTIMVAGGIECNLDAMRQARDRLVQDNGKERVTYMEFPDALHDFLLFGESHDPERTNTLHALVAWVQTFLDQNSAFSIKAHGTGFRYASSTSSNDIGVSTSDDLAYTVDITLGGQNFTVLLDTGSTDLWVNTAHRALRLTDSSSFVTGIGYGSGQIKGNIDFAELKIGDFVISSQAFLNHTSIKDFSLNGVDGIMGMAFDVASIYSTVQDAWGTTAAEKLARAPITALFAQNSSLPNNFDVQLGRTSELDDIAEGTFQISNHAAGFEAVTKAPQLPRVSAEHWSIVMDSMKINGKAFAFNKSRISGTPSGKIVAALDTGFSFPPLPAAAVDAIYGSIPGAKFDRNGDIWIVPCTGATNLSFVFGGQEFPVHPLDLTWPFVFQMPMRNNKATNVTTCINTYQYLTLDPNSFVGFDVILGDAFLRNVYASFDYGDDYPGNHRTGTPFVQMLSTTNASTMWQEFTRERKATLAKLPPEVDPATVVAYDTQQASASASQNSGTNDFAVSGASSSESGSSSDSWSDKYGMVALGLLAGNLLVGVILLALTLAMCVCGMKGKSSGRYTPVRLQDGARDFESGRVGKYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXP1</accession>
    <name>A0A2G8RXP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXP1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXP1"/>
    <dbReference type="OrthoDB" id="2749026at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="690" mass="77750" checksum="EA6FA2DB6D099D7B" modified="2018-01-31" version="1">MWLLSTDRAELHYFSRNSDANGGYAILSHTWNKQEQSFQDVQAIGEDSFEAGNNPRDHPELSPKIRGFLILAEKNGYRWAWADSCCIDKTSSSELSEAINSMYQWYAEAEVCYAYLADVPGDDDVEAPDSAFQNSRWHTRGWTLQELIAPESVIFLSSDWGRLGNRAALATLLQKITRVPAGILTGEDRPAEFSASMRMTWASKRQTTRVEDQAYCLMGLFGVSMSTNYGEGKKAFIRLQHEIMQHNPDMSLFAFGRFLDQEDIRDHGITLRSQGRIDRGNSWQYLMAESPQDILNTFYYIPDLGSNAKQRYPPESLSSESGPGDDSTATHTGPFDSIEMPHISVTSYGVKLRLPVATVDNTTIAVMLVCAGDGRNFGLFLTKDPRAKDPRKPRYFIGCDFTQSATGAAPFLARMADLGHNLYNLTFNGKQIEPKWRTIYVVSSASHFDAGSATMPSLMINSNPASRFRFPRWLVSRLVSLQFEVDQVRNTDMLQVIRIVHRFQGRIWISLGLCTSHHDHDNSPPLWAKVDIVPYIDPTNFPHNCSEDHIDSKSWAGRSKEFGNTDRRVRLSFTPSTRMPDSKLLISLELFGSVFEKLLEKSAISFPSLSDLERSTTPPPTRLARRRRTASDAWGATLSQSRDTLVTQTSQTPLISSQKSSSNSTTTFCAWKSWILRWLLTRKRQAGSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY07</accession>
    <name>A0A2G8RY07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY07"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY07"/>
    <dbReference type="OrthoDB" id="2801388at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="954" mass="104335" checksum="E7AA2CA5F99A52DF" modified="2018-01-31" version="1">MVTSTSSYPHATSPVLSRITTPARILRATPASYLDGPSRRVVFPDVNAAVAGLLDDPDLFAEVPSFEATHNHLDPSSDEAEAQDLLTRSLSPLTRTPTPEPNQASSPRDPSPDLAYLNTLPEQWPDLPLARPNSAQPSFLPIFGHLVQQLRARNLTMAQPYRIAPARRLWRTLAGINDDAEKKGHAVRYVPDSEKTIWRAFPEYANDDSTYEDFKRVVKIEYIGEDGVSLFSRRDLDLHIAATATTTINSVKDFNVYSRKFRDIASFLVSGRQLRTDDRDHLFLHGLPLLMRTSVLERLRITVPATRYPRDPYSIAQVTEAVHHTLEAATLGSSTATATNPTSTQVPQVKSELTQAVESLASIAAAFMQAQKTPAASPLGAPPFHQRPLPPHMAAPGNPAVPPLPRTCIYCSDASHSIRVCPLVDSDLAAGLVRRNERNQVTLPNGTFVPNAVTGATLRERVQKYHQLYPEVRTQAVPQLFFAPVHHTVTAEPTYALATLSTLPPTSRDPGTDLEQQIEARRQELYALEQQFAAQQTPRTTAMANTTEARAERARRRSVRFDDPPVRAPTPLPAAHIEELSDDSADRPAPPLAPTVARPAPMTSAPSATTPSTTSSTSLEHPFADARDATYAPPSQRNYGLPPPRAPLGSRKPDPAYRARPPVYDPRHVANVLRRCLEQPIMVTKEELLSMSPEFCASTRELCTTRKVPTEPILAQDEVTLPFAGDSDEPASDQPSRKHHVLLSSLPAAFEAAQGASSADPPPGTLVVPDPVDMYLKSLPADAERKPVKVSVESAAIRAIPGIFSSGTEVSCIHDDGCSIVSMSEGVCHHLGLSYDPRVILQMQSANGACDYSLGLARNVPVRFGTITVYLQFHVIRSPAYDVLLGRPFDLLTSSIIHTKPDGSQTITLHDPNSDTVTTIPTAPRRPPEFVHTDPSRPAHHRTTVEDVPEDFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYU8</accession>
    <name>A0A2G8RYU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000040">
        <property type="protein sequence ID" value="PIL26693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYU8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="880"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="936" mass="101572" checksum="F21C029CB0CA9893" modified="2018-01-31" version="1">MDKPPPTPEQITKMIDWASQLHYGFRARPPLGANDRASWEKHFLTTFSRVLKLLAAAEFKYLPPFALCCIWENNRRSHAKDPGFDIERIRDTYDEAHPGRHKGQGKLSYEAAYDGPFALLPESQLKTVWWTQSVTRGCAGGAGRAEEQDVQMAREAGRTDEGVDDNGGHADEDMDVDAEPPDEDLYHGVGRAGDEMEDEGCDTCENGNAGCSLSFKDKSDHCLATYLGYAWYTMVSNPDVYAPPSFSPPSQLPTVLPDKQDIAWFREQYKAQPRGSSARTQRKHSRTAAAAAAVESGSYDGADDDDDALEALNEAAGDNEPQPPAPPATRSIHMSKSRASSVASSGANDDDDPEAPAETSGDDEPQLPAPPASQSVRKTRSRASSIAPSRAASPAVASSSTPADDLAADERDYDVPPVYDDNLYGRLRDYDSPNDDDTAFDRLESPTAEGSAAPQSRAFEVLRPPVKKEINISRIRNELAHASTARAAPPALPSRPPGVMKYVKAPFAVKPIEDTYESLPRLGHQLRTGQYMVVAPPHDDPTPARLASLLRAGRVDSPVLNRLDRRQASPLSPSAARPVTPEGNLFTLPDNVIQLAVDTKAKFDELANLHGQIRGDAEMLRTRAKGFMERHGAAVAALGPAGDALLLDIQYTFSALERINVVLSRLALGFKTVPAVPWNWLVLMELLSKVDELRDLYDSAWQRFDVLEEDVRPVRAEMHRLQLNVGFIQESLDGITNEAVNACEPLLHNVFEHFATRLEAIEQRLRQIDGGAPSPVGPAEATPGQVLKLITSLSERLDRVERSMGDQLRARVEVTVANYLAERGLADDVLRELGARIGYPPRPADVGGSISDAFNTVYPPPIGGPQYGAAADSRTTMTQGVEASGSSGGAVPPSAASRVVSTRPANTSAPAERRLRQLKELKGHVSTPGPQRPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYX9</accession>
    <name>A0A2G8RYX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_11205</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000039">
        <property type="protein sequence ID" value="PIL26726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYX9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYX9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL26726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="536" mass="60598" checksum="83E1AE8F7932C287" modified="2018-01-31" version="1">MFSVLLQAVLICTSTWFLWKFFRQSVVRSNLDNVGHVQKLRDKQGWAFHQEMADKYPAVARLAGPMGRKMLFVHDPKAMHHIAVKEQDIFEEATWFTRLSLRTFGPGLTATLGEHHRKQRKLLNPVFSINHMRHMMPTFYKVTYKLREAIEQCVRHGGGPTEVNMVMWMGRTALELVGQAGLGYSFGKLTEETPDELGDALKSLMPAMATLGAFLQFLPLAEALVPERWLAPLGWTVPVLGLRELMRISRTLDEKSREIYTKKKEALLQGDEVLAMQVGEGKDIMSVLLRANMAAAEADRLDEMELLSQMSVLTFAAMDTTSNALSLTLWCLAKHQDVQDRVRKEVREAREAASGSDIAYDDLVSLPYLDAICRETLRVHVPAPMRFREARKDVVLPLSEPIRGLDGTLMHEIFVPKDTHVFVSISSSNKNPDIWGLDAAEWKPERWLSPLPETVSDAKMPGVYSNLMTFWAGGRACIGFKFSQLEMKVVLAVLLTKFKFELTEKPIYWNLAPVTYPTVVADGSHPELPLKVTMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ13</accession>
    <name>A0A2G8RZ13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000039">
        <property type="protein sequence ID" value="PIL26727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ13"/>
    <dbReference type="OrthoDB" id="3210262at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836158" description="Transporter" evidence="1">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="19127" checksum="42D1553AFB86A290" modified="2018-01-31" version="1">MKFFSTFLAAAFVALLLNVAGTMAQTSDQVISAIQSFITSSSNLDAEVTPLNAVTFPTMGFIIAEGFNNITSAVNTFNAEFSADTPPYPDDAAVAVVDVFTAFVEVHQDLLNVVIGKHTLAAMFGFVAPIAAALRSLEGAVVTFAFALLSLVPTESGPFTAQLDALAATFANATMVYGGVTSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0B0</accession>
    <name>A0A2G8S0B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0B0"/>
    <dbReference type="OrthoDB" id="3232670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="491" mass="53729" checksum="C0AED866522E07F5" modified="2018-01-31" version="1">MFNRTAEYLAHGARSLGPLARLQPEQRRRVEKSSEKISKVLGERPIVDITSSSGGPDGITSEAKQGKKGGKSKKKGSSPPILRLKVTPLRRKSSLLVPRTPRTPRAADTRANRRPLKPVPESVEPAVTYVPRFLPPGSRPAVRISDTSTLQDALFLSPLTPLSLFSPIATAAALEQQYQEVRQLAFAYHALYNSPKEVPPVVEATERVKNVGSYLDLYRVANRGVRDVDADLNTAYAACMDATNPDDAYAAYVACPPLSPKHHRRRSSSFSHGPRSGVLSNDGTPIPRSSYIVPHSASAYSFKDQPGRYSLVIQIPSPLSPTALISFTSSAANSSHLSRSRTLVLDTSKRIRRGTLSETSGDESCPLQKQQREARARAVFAAMGESAAPASTPPVPQTPARTPHGPYWVRQSYRTSGQGSIRRRKSSTRVPPTPCTVRRERRQGWGGEWKAGKMGAVVEGLKDIKTPLPRASWRLTDEEVPPVLKDFIVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0P4</accession>
    <name>A0A2G8S0P4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0P4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0P4"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252">
        <property type="entry name" value="HISTONE DEACETYLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48252:SF77">
        <property type="entry name" value="HISTONE DEACETYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="225" mass="24627" checksum="B122562EDD3C14E2" modified="2018-01-31" version="1">MYLDFDLHFSDGVSEAFLGSSAGSPYPQVLTLSIHHAAPGFFPASTIAALTDPTDPDFDPFTLCLPLERGASNKTFHRIWPLVERIKDAFQPHYVVVQCGADGLAGDPYATWNWSLTGEGSMGWCIDQICHWKSKMLLLGGGGYNSPNVARAWSYLTSVALDRPLSPEADIPDHGAFPFYAPSFTLDVPPGNIQDQNTDIYLAHVEEVFAQVADAILQRVQKPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0Z8</accession>
    <name>A0A2G8S0Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0Z8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0Z8"/>
    <dbReference type="OrthoDB" id="2638860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="29"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="81" mass="8802" checksum="B315C6423FF65881" modified="2018-01-31" version="1">MPAAAAHHLALDQPLITLITHGAAVKLLTLVGFTALLYDHLVTLPDEISLIWRGKKGVVSTIFLMNRYIVPVILALDIFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S173</accession>
    <name>A0A2G8S173_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S173"/>
    <dbReference type="OrthoDB" id="2786563at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="48432" checksum="D51609F3C6762A77" modified="2018-01-31" version="1">MLSRRSAPRARLATLADVPEEILERILALVLIQSPEPSRPSWHIYQTPPTTSPGVVSPLLVCRSWLRIATPIHYRHPVLRTPRHVELLLRALRHDPSLVPCVRSIHLHATSPALRQLVPLCSNLDTLDITVDNADSSPITVATGVIPAPPAQDAPRDRSVVEFCEAFGKTRGIRHLVIRKNAYLTQPNAIYIFEQLAKAIAHWRKLESVNVAFRMSPSPAASALTKALAVAPRLHTLSTMLPTVWNTTLLDIAQNPALRRVVLDPAPELVGAHLFLAEAKRHPRLIDLIQAGSPPPSIHYPAHASIVANVRARAASAAVMGTLPMSVPTWGYDRDVPPPTCPPVSRRPSQATYAPGSFAGPSAYAYAPPPVAGPSTSYPGSGMQYPPAHRHHREHQHPVANYPGQYYAYGTPAFHAGAGARLPQPAIVGGQPTARRSTPGGRRMTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1E5</accession>
    <name>A0A2G8S1E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1E5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1E5"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000109">
        <property type="entry name" value="Related to MLH1-DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="234"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="754" mass="83130" checksum="46983423FC888649" modified="2018-01-31" version="1">MASTAVRVGSPTPPGPRPIRRLQESVINRIAAGEIIHRPASALKELIENSLDAGATSIKVTVKDGGMKLLQIQDNGSGIRKDDLPILAERFTTSKLSTFSDLKRLTTYGFRGEALASISYVSNLSVITKTKTDTCAWKACYADGALTPAKPGMTADAKPCAGNDGTTIVVENLFYNTPTRLSALRGSSEEYSRVLEVVTKYAVHNPHVSFMCRKVGTPSPEVSTPSSSTTVQVIRLIYGQTLAKELLTVSVSSSDKGKARASSPMQVGDDDEDDENVEAWNAEAHFTNANHQAKKMIFLLFINHRLVESSRIKKAIEAVYNGVLAKGTSPFVYLSLQIDPRSVDVNVHPTKKEVHFLNEDAIIEQIADVVQQALIGQSHSRTFEYQTLLTGGIAELPASQSQKAKGKRKAPSDDVHSDSDSDSDSHSQDGAPEDGEFAAGASHPAKRKVYSQHKVRTSLKDRTLDSMFPIAHPSQRPSKESEADGSSSPATPPVLKTQEIKESRCFLQSVRALREAVVKAKHIQLGEILTKHTFVGVVDAPRCLSLVQHNTRLYLLNHGALAAELFFQLGLRQFGNFSRIRLDPAPDMRTLVALAVDAEEGVEEGGLSKQEVVQHIVDIVMARREMLQEYFSLGISEDGLVETLPMLLRDYTPNLDKLPLFLMRLGPQVDWTAEQECFESFLRELAFFYVPEPLLPDPSTDEEAQESEKAMLWQIQHVLFPAMARYLVPPKTLLDRDVVQVADLPDLYRVFERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S295</accession>
    <name>A0A2G8S295_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000033">
        <property type="protein sequence ID" value="PIL27885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S295"/>
    <dbReference type="STRING" id="1077348.A0A2G8S295"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="32"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="234" mass="25179" checksum="1619DFED47BEE4F6" modified="2018-01-31" version="1">MPSPSTLGASSSALPSSAFTSLPPSSLPAVLSDESALILDIRPHNSYSQARVPHALSLSVPSTLLKRPNFCLARLAEMLPTSAARDKFAGWPHASRILVYDADSAALPPTSNLLGLMRKFRNEGFPASREIAWLRGGFHAVWREHPSLVEHGPPQDVLDEDDVTGEPEADGDPAPLGRGAPTRVLRAKHLPQAAFTSASTIPFKPRFPVLDVDLDPGGSPIKDDAFEEEQHFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2A1</accession>
    <name>A0A2G8S2A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000033">
        <property type="protein sequence ID" value="PIL27881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2A1"/>
    <dbReference type="OrthoDB" id="2758769at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="299" mass="33002" checksum="726FA1B4DA8713EC" modified="2018-01-31" version="1">MREDSSMKSVYTPTAVSVNSRIRLPCGTVYEKLGDGQWYHYQGGEAGYNGFLPSNHDFPHGSEVTYNGQRCFIKDGDNWWPTPCASTSVPSPSASLAFATLRPEEHGQLFADPGDDWWSTGLQLATTSNLTPEIADLDSDLQSSSDAAAEASSRIQILEQVEYRYGTLPVHDRLVEFGVDMAAAARGDVPDADRPAYEFDLVEKEKVAIRFGFAHIHSCSYRTKQRTISRSRERTGITRGRLAMLVAQEVKELVDALARNNTPLKAADGRALKFEKLVLVDVQRRSAASVQPTIGVRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2J3</accession>
    <name>A0A2G8S2J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_09916</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000031">
        <property type="protein sequence ID" value="PIL27972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2J3"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="126"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="239"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL27972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="330" mass="35685" checksum="5AC9C238553969CF" modified="2018-01-31" version="1">MTDAPQATLREISPVLDFFAGTVAGMAAVTVGYPFDTGRSSHLLGTSIYLNFATRLVKVRFQNPHIASKYRSTAHAFLTIIREERIRGLYRGIVAPLAGAPPLNGIVFSCYRSLLRAQLGDDIATPTLTQITLAGAGTGIVSSLITTPAELIKIHQQTLVRSASSTSTLSDRDVILHIWRTHGLRGFYRGIAATALRDIGYGAYFAAYEATLRYWPRPHASHTQHASRGTEVESTLASHSWTALLVAGGMAGVAGWMVTFPFDVVKTRVQSTQGDAPGNPYRSTWSTIAASYRAEGLGVFFRGLAPTLIRAIPVNMVTFATFEAVIHLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2Q9</accession>
    <name>A0A2G8S2Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000029">
        <property type="protein sequence ID" value="PIL28056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2Q9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="79" mass="8190" checksum="A04AF57FDF520FAF" modified="2018-01-31" version="1">MPRKVGAWRTQNLGQHAQKRGVTQLDSDPQAAPGSEVTAGSDLTSSELSSGPSKKPRIEDLAPQLAAASDSLPPSISPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2T9</accession>
    <name>A0A2G8S2T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09741</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2T9"/>
    <dbReference type="OrthoDB" id="2740834at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="49752" checksum="64CBF12CE4722A3E" modified="2018-01-31" version="1">MILSLPQIQQVSITGLLLCPSKLPHDDYRIDSLVPLTSFHYEVFSNRFNGMQTRHDYPFPSEEEVLLLVLSRIHTSLEKLVLSTEPAPLLAMSQWSWPRLRELRLRGERRSLPPVPYMTLLSAMPNLRTLILGLTLVSEECTYASPLWPPGSRMPFPWPDLAHLSVANPNPSDELYSYLPPSVRVLSLCCRPHKSEEAWIGRRLMFTVHVYEYPVPTSAEMLGILENCQLPHLTRLEIEYEVRERAGEGELDLLRSLGSMFPQLTWLQIHRYRVASATPSGDPGDIDVAPLASQIQTQAEAGLAPAGELDFVDDIAEALSHLSTLHTICTYLDLPQQPKIQDDYPFYYDRAEIDEYTTALRDVAHRLAWAIPSLETLYFWRPRRSGHIEWAPFEVVRADGAAKGDFEFEIRCPEDVRTYGGPCYPVIPMPDRYGVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3J9</accession>
    <name>A0A2G8S3J9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3J9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3J9"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48896" checksum="4B6265ED35C7E9C7" modified="2018-01-31" version="1">MSKPSDFGPLPLRFSELKKEIAASIPDFETRATKAWGEILVELDKVTKEIAAKGSANVPEVNFTELGTLTPERVKEIRNKGCLVIRDIVDDQEARTWQAWLRDYVSKNPVPGFPADDKQFFEVYWAKSQIRARSHPNVLSATTWLNKMYRTKNGEKAEGIDLETPLVYADRFRIRRPGIQWDAHPPHVDGGGIERWEDKAFRACFHDILSGNWREHDPYNLENRINAKSSLYGRPNQATVFRTFQGWLALSETAPNEGTLQVFPNVMLSNAYTILRPFFAPKESADPESFDPNDWQLDTTSPEFHGIYANRGGFVGPRPTPKTHPHLRLEQTMVSMPKVYPGDMVFWHCDGIHAVERQHTGKEDSVVMYIPATPHTAINAAYVEKQRESFLAGVAPPDFPRTQGEADYAGVGRADDIESAVGRRAMGFAIEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3T8</accession>
    <name>A0A2G8S3T8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubinuclein middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3T8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3T8"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026947">
        <property type="entry name" value="UBN_middle_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14075">
        <property type="entry name" value="UBN_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubinuclein middle" evidence="2">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="165" mass="18202" checksum="9F248BBA0C39E9A5" modified="2018-01-31" version="1">MLLPGSDDDGGIQHPFSAELKQAIAKENWEVKGKFPPGIKPLLAQGALKAVILGEYDENFFNLMPRFFPYNKFTMTNTLIKHLRCLAEDGFVKAKEEGEKSVMQWEKRQEHARLEASGENVGHSHEGSPVTSDAQATPMMPRAALDHSALPADDGEHEESGQCGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3Y3</accession>
    <name>A0A2G8S3Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3Y3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7836" checksum="502E6B142B6D1532" modified="2018-01-31" version="1">MLVIVAIITVVFLILLLSSNIALVFLFREMSKLGRLELVTPILRRVVVNNDDEDDDEDDIVDNDDNHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4K0</accession>
    <name>A0A2G8S4K0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4K0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4K0"/>
    <dbReference type="OrthoDB" id="2758235at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="412" mass="45247" checksum="0AEE4F7E5FC80F07" modified="2018-01-31" version="1">MALGSADLVVVPTPSDNDRIPELVINLPLASSIYVTYTCLTVKRTNDGAKFLLNKTTAPILIKTIARIFIDIRETLADPNANRSTAAYSLVNSFIWLHGVLSNEYVKAVINETSLWFATLPSWPKRLSGHDDADRWEPLPGHGFPRENDYMLRYLRTLVACATSVFRLSDPEVLPLFAAANVTVISLPAPSHDSSHAESERRRIVQALIAEIGTRDAPADAGWPQTASEWIGRLADTVALEEQKENSPSCRLHAEAGLMALACEARLSRSRGDEHASDKYGPALSESNLARTAMSIGTSGKCCPLCFRLTYILNAHFADASQPSGDPEALAFSHIPTHGKVLPWDPPQFGIPRAVLTQLRDELWEKLVEEAVRVGKRDAPKTDASSHSHEREPEEDMLAVQGRITLSEDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4W8</accession>
    <name>A0A2G8S4W8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4W8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4W8"/>
    <dbReference type="OrthoDB" id="5327923at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="62598" checksum="F7DE881825C4D4E9" modified="2018-01-31" version="1">MTTTALNTAYVPHDPSSLSQPESREPERTCVVPMPPDLHAASVEEGLRSPVVNLKVEDGGATGKSQEHGRNVPSSGGHGVDNSQPLSFLRELIEWSPNAGVKGPAWLDVAVDLPKPAHHSVPKGDGGLPPSTGIGGQGAATIVPQRPGHLKAPPRDRADPFSLVGLSTLQTFIPHDLFPDDLLVHDPDNITKLRRHKSPSTSDKPFRYVRVFPNLKAPYDPFLPFNLRFSTDLKAPHTDHLMPPQPAFSNRSPKERVRVAHLYLKAGNKLGSGHHSSVFSAPLRMRLNPASAEETIVRIAAKTASGTCGAHKMLHMEASVYDSFPRQFMDDQYYAAGTAAAPTAAQLPFDSKIDPTAALAGRLPTNEGNQGAVTARRIEPAVVPKCYGYYVAVTSDGTAIMPTHSNCGLDATCSVSWPTHILLVEECGRPIFPQVFTQEQKLHCLQLVRRLHAAGFAQNSMFARNVLVQPGPLSAPLSARSYTTPSFRIIDFGRGVVFSHLPPGNERLFLNVCEAEEWCAVHKVLELCKAGTKGSPCRLEVEPVIHLDEQLCTLYKNVMSLHWSGQERRRRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Z2</accession>
    <name>A0A2G8S4Z2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Z2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4Z2"/>
    <dbReference type="OrthoDB" id="2418900at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="990" mass="112428" checksum="16C5381C6BB3F213" modified="2018-01-31" version="1">MADLRCRGCKVLFNNQKSKNQHIGASPSCLNFYDKESTHFSAHPESSSRQPRPQLPIDPILSPPFSHQPIPYRDSDEPTYDLPSPSRASHPHPDENPPKRRRVMIEEVEDVDTNEAWAHEKFPRPVATMQGSGVTAFKDQLTEQKSMREQPYSPFRDRKEWGLVKWLMRRTTQTGVDEYLKLEITRDVTKPSFKHKGSMLKKVDLLPVGPTWNVDDIKVTGDLRGPKEEFLTEDLELWRRNPVECIADLLGNTAFKDFIVYEPVKIKRNGQRYYSEMCTGDWWWKIQSRLPHGATVASVVLASDKTQLSVFRGDKTAWPVYLTLANIDKEVRRKPSSHASVLLGYIPVAKLACFADATRSDAQQRLFHACMKLLLAPLIKAGKDGVLMTCADGLIRHVYPILAAYVADHPEQCLIACCKENRCPRCTVPRDSRGEETSYPLRNHQVTLDLLSQSQATEDNVPELESQGVRTSAPHPFWAELPHTDIFATISPDILHQLHKGVFKDHLVEWVSKVVGRTELDRCFASLPQCHGLRHFKTGISTLTQWTGAEAKEIEKVLLALLVGRVDPAVVSAVKALIDFIYLAQYHVHSETTLARLREALSAFHCYKDVFIQLEIREQFNIPKLHALLHYLEAIRSLGCLDGLNMETSERLHIDFTKAAYRASSRNEYTAQMTTWLQRQEALVRREAYLAWALSTIDEEVDPGEESSDDESDKDQDETAGDEDADARSAGKAPVGSEYDDAQEAEYKTLKLLLASNVRRAYQLPLTPSARRVSLSDLSTRYGAIDFLADLRAYMTTYLPSALPPNEYNTYDVFHDINILTPASRYFDNSKRICKVRASPAKPRVGHRRPAPPRFDCGLFVVDEDLHRREGKLNGVCAARIRVIFHLPSHLGYTPHALLYVQWFRPFRGPEQHSGLYTTSHSTSNKARRHSIVSASTLLRSCHLIPKYGPDDVDPDWTTDTVLDAPTDFFLNTYIDFAMFHELSFPDRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5K8</accession>
    <name>A0A2G8S5K8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5K8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5K8"/>
    <dbReference type="OrthoDB" id="2750723at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="651" mass="72230" checksum="D13B2ECF4BBDB651" modified="2018-01-31" version="1">MADCVHGDVEIPGDLHLTVTVPTASDSPLRHQIQNKTTWNYTLPVNNLPVEILASIFFHVQQIDFILRRILMDIPQFHPSSESGIDKLPPSWTGVMLVCRHWREVALASRKLWCTFNPNFRSKAEWIHLCLARSAPATLYVDCEAIGAHHPLHDRLFPHVHRIRRLHYGTLSTKSVHPALALLGEGMPALEVLNFQFDLRHHRLGELTADRLHDLVLTHHRFPRLFDLVLVGIAAPSDFALFANLRRLCLRHCAAKFSLRHFLEALDATGALEILELSGFLQHLCDDRQITPIAHRQPLRLSRLTRLLITKHSPSLTSHFLSHLIIPSTALLYVYSLLADVREDEVQETIAAIVPPKPAASLPVLAQVADVEVTVHDRTYGLRGGRRTGVESYGIYSLLHLSNPYVTPPKIPESHLVTLSICSPAFGVWERSLPKALDDLLHVFASATLTTLKVVAHCQQADAPTWERVFLHLPHLASLALLVPLFSDVYGEYACTGTLGEADTVFDGLLAASRARSSSATADPPNSESSPQTVTACPCLKAVSVKMDGLVSPELLESMVECFRFRAGQGARLERLAIEQRSGVALAPALRRAYVSQLLEVVGELSFCMVVDGRWRDYADASDPSPGFYVSDDSVSDEFDKESNGDDSESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S649</accession>
    <name>A0A2G8S649_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S649"/>
    <dbReference type="STRING" id="1077348.A0A2G8S649"/>
    <dbReference type="OrthoDB" id="2747626at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="197"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="357" mass="39223" checksum="87D7B10D64EF13EB" modified="2018-01-31" version="1">MAVLFKPPVKKSASDATNPSSSLGLSALGTPPPQKVVFRASLTDQTAIFPAGWGLLYWKPPARGISAAEGEIRYRIIASIASEPRAWSTQKVRAQFAASTDFCTADGKPWSASLFASVLRQLAYSESLVSPQAMADTLSDHFAERYMDKRRVQAMTDPALAFLDRLPTIDHRSVLPRVEQFAIPDDSAVAIRAWEADTAPTRVYSDGALHRDGSMGAGVVLEHITKRGRAVRRKTRRVHLGKIPPFPYNVHDAEIVGLGEALSLAAEEPALTRLSVYTDSRLALNAVRSSAERPGQWRLADLVLHRYDALLKRHPNVEVIFRWSPGHKGIEGNEIADSLAAKASIPPRPRRERRNIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S661</accession>
    <name>A0A2G8S661_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_09284</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S661"/>
    <dbReference type="STRING" id="1077348.A0A2G8S661"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL29235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="552" mass="62368" checksum="21903D1386241241" modified="2018-01-31" version="1">MAISLVSQVFLGTFVALLVAVLWKLGPYLLIPFRSSLLNLPGPPSPGWLFGSLKDVYYSDGSVIIDEWIEEYGSNVMHRGFLNMPRLFTTDTRALSHILTHSADYQKPEEERKNLSDILGRGILSAEGDQHRQQRRVLNPAFGPSQIRELTDIFVSKSNELRDLWMSTITTQGEVARIDVLKDLSKMTLDVIGLAGFNYNFNSLNPHDKPNELGRLFQEAFNVPDKIPILLILRTFFPIFRLFPDKQLRTIAEARAAMHRIGMQLILEKKAEIARGQAEKNSDQEKLLDGERRDLRSRDLLTLLIKANMAADIPESQRLSDEDVLAQVPTFMVAGHETTSTATTWCLYALTQNPRVQQKLRDELLSVETDTPTMDELNALPYLDMVIRESLRLHAPVPAAIRIPVKDDVIPVSAPFTDRNGEVQNSMKVDKGSPILIAIQALNRLKSVWGEDSYEFKPERWENPPEATANIPGVWGHLLTFLGGPRACIGYRFSLIEMKALVFALVRAFEFELAVPPSDIAKRVMIVTRPLLRSAPEQGMQMPLYVKPYKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7A6</accession>
    <name>A0A2G8S7A6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7A6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="175" mass="19984" checksum="89F3FA153992875B" modified="2018-01-31" version="1">MASTARPSAILWEAREESDELCGIIESKLVRRITDRVSGYVLRCDVASQTKAELQSELKILIRQIVDYDWIANKNAPVERWLVELPMAHDLYARMTERRLAVRMGALSSARDQALRTDRMAEQLADVSHDLTERIERNIDYLCSPEASDAAAFEEWEDMPELEEPGGPIVFKAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S873</accession>
    <name>A0A2G8S873_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_08167</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S873"/>
    <dbReference type="STRING" id="1077348.A0A2G8S873"/>
    <dbReference type="OrthoDB" id="3261476at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL29728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="102" mass="11757" checksum="508AA5A9EB43404A" modified="2018-01-31" version="1">MDEGGPMCTQSINGKNHHYVSFIDDYSGYSALYYLKHKNQAHKVFLEYKAWAENQTGEKIKKVHSDRGTEYISKEFTELLKTHGIEHHKSTPDSPQQNGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8N9</accession>
    <name>A0A2G8S8N9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8N9"/>
    <dbReference type="OrthoDB" id="2752736at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="196" mass="21646" checksum="BD49DBB81D25D765" modified="2018-01-31" version="1">MDRGHYLAPPLPLYLADPPEPARSSDSESESAPSEAAPTAIPHPRLDTLWILVQSRKEIRTLKKILTARDALGFPIRCVVVHHRFAAGSKALAQLQALRAEEVILTEPSASAPKELEEREGDWALRFPERFSLPAVVRRDWPTMWYGNDWDSQDDDSESEDESDSSVARSGRSSSEFNPFSPSSSVHSSGSSSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S945</accession>
    <name>A0A2G8S945_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S945"/>
    <dbReference type="STRING" id="1077348.A0A2G8S945"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="23929" checksum="71AF4E3D1B6B5F05" modified="2018-01-31" version="1">MPRLYPGHSFARHGKHALYHLAEKPEIVGSLRDEIEAAISADGWTGPIALGKMWKLDSFLREILRFHGVGLYSMGRMAMKDLTFSDGTRIPEGTLLNAQAYAMHHDDALLDSACTFDPFRFARMRSAEDQLQGVKYLCTSTSPEYVPFGHGPYACVGRYFAANELKTILAHVILNFDMKLGGDGLRPPDIYYLTAIMPAPRGCVLFKKRESPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9P3</accession>
    <name>A0A2G8S9P3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07178</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9P3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9P3"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="77"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="282"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="654" mass="73181" checksum="9B4E13DC57AB1559" modified="2018-01-31" version="1">MSTPLDPLSPQSHIAVTPPAIRGSPSVLVPRLFKTGSPPPAPISPPPNGNVPAEPPGPSTFSAAQWCFSSSIIRTLRRMKTAGPFLNPVDPLELGIPHYPQVIERPMDFSTIERKLAASNPSKPDPNPTYARYYRVDQFVQDVRLVFANSVKFNGPEHPVTRMGKQVERIFDKQIKQMPPPEEPEAPTPVAGPPLFPPPSSSTSSPPSSPPPKKRARRPPVPVVLVIRRNKEPTGRPKREIRPPPRKDVLYTATSPALFKDKAPKNAVAAEQLKFCEKPARRAESLSTFTTPQVSSREHVNSASQRHALSVPAPNEADRNREQGSSASGLSASGQLPLPQWSLSDDPSTQSPSPPIRLPPLLPQTQRQHAQLQAVQKAVSAERERFKKTDDRNAHLTQVRRLFSDVFQAPADEDFYSVHVAAPREEVDRYLDGEGPGPDTGDLHFTDLEPYNNAWNCAVSRHLAHMVWDRQSTERWTTKKGGRAASASEAYWEDLILQKFKRVRKGWMDAQRKVVQDPATGQSHIESLEEAETRRFGKGEETRTVARQRERRFKRWERRTGICTTKMQLATVPFEKTRWTEFLKIIDILGKDGMSSDESTEEEVAKLPAAFYNDDWISTRSDEYVHGVLYGSDQGYEWVIRVAEAYNGRAANNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9U7</accession>
    <name>A0A2G8S9U7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9U7"/>
    <dbReference type="OrthoDB" id="2757887at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="525" mass="57629" checksum="9D41DB524F4FF505" modified="2018-01-31" version="1">MQRIRKISNDLRDAFLPKSGKPELRPRPSYRITQPIQTIDSKKTANRSLGYNDSTAVTTGSSREAWAERERRERDVRRQAMKPAHEQRINGSSVAFPSSSSHSKPRTKAQEKPVPVPLPSLNHKQAAAAGTSWDLNAGGSPPAMSPYRYALDPQTKPLPSPPGTLPARKPHKRPPYSPSRFFTASQSTPDVSRLPPETGIPTTRERTPASPDDTQGQSGTPSWPPEGPAAVKRQQRTPKSSIDSLYRSQTMKDLRTAAMTDGPRDVGHGHSRTASTPTTRDAQTLPRRREQQAPLAVRDPRLRPAPEASIPDDVSEPSVYSQSSYRTNGSSAVEPKKSLQVRELPTSRSVHVQSNLNVRRAASRKAQIVYPSYVTTPLPPLPVSASVPAPQPQVAALARRLGREPPAAPRVNPPPPTATTTKGEDESHDRSPSATKSRKQKQRIEIEYISMRQIAEMESEKVSQNLNRELAEWDRVNATTPNVVPAAPGPEPSKSYGGTRPLVVKKRPAFLGLGLPRTSHLQLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9V6</accession>
    <name>A0A2G8S9V6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07242</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9V6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9V6"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="264" mass="27471" checksum="5D99703FFF1F8196" modified="2018-01-31" version="1">MMVNEALPSTISRVAIVTGAAQGIGEAIALRLADDGIDVVVNDLPKKRDQLDSVVKAIQAKGRRAVAVVGDATVESDVVALVDAAVKEFGSLDIMIANAGTIEMKPLVDMTVEDWERVMSVNALSVMLAYKHAARQMIKQGRGGRIVGAASMAGKKGFAYVSSYCASKFAVRGLTQSAALELAEHKITVNSYAPGIIPTGLTQHPDDEKNGGPCSTFLLGAGLPPSTPSAPPTVVAELVAYIVKPEAHFLTGQCLSIDGGIVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Y2</accession>
    <name>A0A2G8S9Y2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Y2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9Y2"/>
    <dbReference type="OrthoDB" id="2724111at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39246" checksum="543614DB78D89DC0" modified="2018-01-31" version="1">MDVCPNEILDLIFSEACVDDGFTGRSLSLVSKRIHDTSRRYTFQSIALYGPHRISSFAHVLDKADLKYHTIRHLYLADRSRFWVEGRPDQDKKRDTPPARIRLLSRPSRPQDRLPIPQMLTLLLFDKYDEQPLSDAISLPRLHELTVHDPSLARIPSPLPRCLSLRRLHVIFALGRPWTAAMSHLAPHLTHLRISGLGSSPLPLMDIVCSLERLPPTAPQDDLASKDAGLVGFPPTLERVLVQLLQNHFHNLDCANQSAQVLLVTPMALHLKNTAMQDVRRRIVLLKPAWMSGNLPELLTGESADVQFYMGLTAAWQRRTEGLESAVWDVERESVLASYGYWAGDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Y5</accession>
    <name>A0A2G8S9Y5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Y5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9Y5"/>
    <dbReference type="OrthoDB" id="2738218at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="268" mass="30004" checksum="3205FB3BFBFE1C42" modified="2018-01-31" version="1">MAEAQPSDMPLSPADIGYSAPRTAGDALHRWYIIHQWALNTVADAFISSRGGIDTLLEPGPRRTLVFTVRAAAEGTENGGNPAKMFKLVNINIVKSEEHYAIAKRSEYMQQRCDNMNADLRGRGIFYVDRTFAGMFCAAFIVAGTGVVNHERIALHRLPLRHVPADLNDSRTRRVLAQSVQFLNTVITSGAVLRYRDSDPREEPERGHYVRTRRSWRFQPLQDDQWESLVLSANRNGATLPSTELTTSEMLTLFDARGSFLTLRNLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAC4</accession>
    <name>A0A2G8SAC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAC4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAC4"/>
    <dbReference type="OrthoDB" id="2801180at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="380" mass="42814" checksum="4E0F26496E8CD7FC" modified="2018-01-31" version="1">MTKTVPPADYQQMLVRLQESAPLLSHLHLNADVPPYDPTIISAMSNAICTFKHLVSVRTGPLPITEQAFRYLAELPHLEVINVRLPDTITEASFRRAPFDEIFPSLRELRLAHLFNLNLISLIVQHTRSPRLEIISAESVDEDRPVPLEDVMSFFSAILSRNNAEHIKELTIEALPIEWTPQNTFTNQHLEPLFALKSLTTLKLHLRCTFDLDDVILERTARAWPNIRTLDLGPGSTGVRVPSLAALIPFAQHCPELQVLGFTLDADLCRVPPDIRDSARDYAQRELRVLKVGCAEVADPRCVAAFLADLFPHLRDIECGSIDANGMEIGAAAEWDWEEVCEEHLPAAARERGIVFEPTLDEIDARVMKAWYIGRRTSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB10</accession>
    <name>A0A2G8SB10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB10"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB10"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF21">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="661" mass="71610" checksum="29E4C75BD9E8E2AC" modified="2018-01-31" version="1">MNAVAGHISRKFIGAVEDEWQLYSNHSSDYTIGPPIGFGASSVVYAAKYQPRDDTTPIPCALKVLDLDRLPPSALRLLQNETQLMSLSKHPNVLRVRGTWVDGHKLYIAMRLMNAGSVADVMRYQWPGGLEEEVIRCILKQALQGLNYFHINGLIHRDVKAANLLIDDDGTVLLGDLGVAAFLWDSGGPQPSKSRTINFDPSIRGAQNSHNHTHQRVPAPSATPQRPSILGKRKSFVGTPCWMAPEVINGKTYDASADIWSFGITAIELAQGRAPRSRLDPHKVLVMTVTEAPPKLERTSGPHSYSSAFAEIVEMCLNKDPAKRPTAADLLQTNFFKNAKKPGYLCSAILRGLPPLTQRQERRKQPSIHTHLTMDSWDFSASLPASPTTSVYSHHRRLMGLVSPEGLFEMEGEAPPDDEDGGTGDGSDKEWQGQGDHAAIDGHSSAEAYAVRIRARHRSSLSVGRSLHSHSRSGSHHSLHSHHSHHSHSRHQSHDDRPTVHSIQEVVVQGADEDEDESSDREGAEAAKGIPVALSPKANVPTSFAMLDVPTAPLSQLSVSPAASTRSSASATSSASSPLTPPTPPLSSSFGNNPSSAKSQRSKLWRKLAGKLDLGESDGWNMGREKERDAAAGSPPPSSSAGSGVRKKSFGSVFGRTQLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB99</accession>
    <name>A0A2G8SB99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_07047</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SB99"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="1772"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="2179"/>
            <end position="2246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="2231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL30878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2246" mass="249446" checksum="766C913D696B51FE" modified="2018-01-31" version="1">MRRKYAQPALPTLYFKDGILSVPGYTFEKAVPWEDTGSMTLLAEGTNLQDGTSVLAKIVPAHSNASMLLEREAHILERMVGYPESSSATLRMIDFFTIPKTNGDCVVLLLFHPGLNILGRYFPPAKVNNLLLGDISRARPASTHRDIYMSGVEEPYIMEEMEAIEIMDLATFLEFAIQATHCLEMMHRHGLIHREVRANAFHLNHHSGLVRIVHFGNRAVSLEQFGVPSEFVLRADAFEEGQKLKVKEALCYFAPEQTGSMENLAEDHRTDLYSLGIMFWTLLVGRGTMPFEGGPLELLHAVVQKRPMPVHEVRRDIPQVLAMIIEKLLSKPPDARYQSAYGLKQDLLECQRRLLAAVALSSDEPAELIPYFEIAGADRCMEFTIPSPLFGRDKELDTIRNIIRHTSTSYSRQLATSRGSFVVGSSGSSGSPGTVGTAEDPSETMSSKSGTSGQMVASSPDSPVSKVSSIGDLPPMPGPGSGTVASGSTIQTSDGLRRVALAPSHGRVRTNAAIILGPPGAGKSSLILTQQAKWRSHGLWGQAKFSEVETGPFASLLACLSHVLRQLIVFHSDLHRFVTDLKQRLGPQLQNVPLLYEGAPELKTIFSLFDITIEPPRETSETNELPARFQSLVENVFSVLAETRLFALFLDDLHEAPDSSLELINALVNSRTRLLIFGTVRSDRPEKLDRIRRTFSSKSTTWITLEPLNYPAVSTLIARTLHRSKEDIAHLARIVHSSSEGNPFSARSILMTLYRQSCIWYDWDKNNWQFDIAQIEKTLFDKKFMTAAPGDLNFLVNHLRELPEDARKFVIWAAFFGPTFKVTEVALLMDWDDSSDSSGSGTEEEISKEMWNVSKAVSTFREKEKESSSTRRSIRGLQTAIAEGWLIQRARDMCSFSHDRYRQAAQAEAESQTQEAIAKMSFRIILMMLHEATPDVYRIAEHAKRCMPLLREHSKRDELMEMSMDAGDSARARGAHELALQSYMNARSLLDENSWKADAPRTASLYMRLAELYTWKSEFTLSDDLIQECLDHCEAPEEKARLLRLRSRNHWMRGNYNAALNDNTLGLHLLGVEVNAAPTRREADIMFEQVKNEILAVGFDNILAIPRARDSRTDLAIALLNDAGTNAYWSTGEGFADIIGLTTIQQALRGGMCPGTALGFFWALGAAAERRELFRFSADLGKLALRIADTYGTSFEKCRAQFLFSIMVSGFDNVHIRANVPRLEQGIKYGQSAGDRIYTSFSTAHLTVTRLYIGDHLSELVVAAEEALSDITLWTPSGDVSILAQATLNCIRAIGGYTVASTAATAFDTETFTESEYLTQLEGLGHIRVAMNWYNAFKVVGLFCLGFVEEAAALGFTVYETRDSNPNHRHVRYSLFFHSLALIHCLREGHLPPEERARYFKQIEINQSYIRKWLSPSPVNTSTWVALIDAEMASLTNNPDAFKLYDVAVKLAVNNDWLLEGGLGLFFQGSHFVRCGVEGLGGELQRRGIARQAQWGARGLVTYLSSLLDTRAQPVALKRHIFSADVAVQTDSVVIATQPSLQGPFERTSLDASEEEQISTLTAADLASILKWSKEISGDINLSMALQRLTEIATEIAVSQSTCVVIAREAGDYTVATSMNPPEPCKVHENPIPIRSIADPLRRIIIQYALNSKERVYSEDIASEPRFASEAQQSPHRSVICIPIFSNRGQTFGAVYLASKYAFSPNIVTMLTLLCQQASIGISNALLFRSVQAGTKENLKMISAQRDALEAARKSREDALKATKIKSNFLASMSHELRTPFSSFYGLLDILSGTELNAGQREIVQTAKQSCELLLKIIDSILDYSKLEADAVKLEYSGFSVENLLADCMELLLPMAAKKLDLSFNIESSVPPWVKADYARIRQVLMNLIGNAVKFTAHGFVQVTCSVDWSAPRTSSDVSLRFSIQDTGIGLSPSDVDQLFVPFQQADNSSTRRFGGTGLGLSISRQLVKLMGGVIGVQSELGVGSTFWFTIPVKTFESEESQEVQAAMDKFKTHLNQPQPLRVLISSASSSTLSMLRTMLDGFDIITASSIDDVEKRLRSPDLVSLRLDFILIDDQSESRADDLTRFLRTLPYQTLEETKVIHLFTPTSDNLAGAPMLRSDMETPPGLVRMTKPPRRLKLLQMLAGLKNVLDGLPIRPVVNPTELREEEALAQRTLFGNVLVAEDNPVAQKLLMKQLERYDLNVVATSNGEEAIAEWERHEPGYFSVALFDHHMPICDGVEACAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBC5</accession>
    <name>A0A2G8SBC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUS-like FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBC5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBC5"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="435" mass="47529" checksum="84F694A36BC09A89" modified="2018-01-31" version="1">MSRRSHPSSPDSSPREAKRQKLEYAPLTADDYKNGLMLAPMVRSGALPTRLYALKHGAKLVWGPETVDKAILHTTRVVDPVTGVVAYHGKSKPIFTCHPVERPFLIYQLGSADPALAVQAAKMVQQDVAGFDLNCGCPKPFSTHAGMGAALLSNPDLLCSILTALREAMPPEITVSAKIRLLPSQEETLKLVERIVDTGISCLTVHCRTRNMRMREKATIGRLREIVEFVERMGKGVAVIENGDCLGYEDSKRVRQVTGAHSVMIATAAEANPTCFSPTPLKDLEMTFVPGYIRLGKYLNNHWTSTKFCATQFQGAHDKARRSDLKTLREAIVHAKSYEDIEAHVAPWTGEQEFAEIVEAIEKRGGQRAPPIPLEDVVVAPLDAIQDNGELKDVTTTELMVPSLELANKEATSPPSLLGLEIPPISNSGEAIAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC29</accession>
    <name>A0A2G8SC29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_06024</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC29"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC29"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17971">
        <property type="entry name" value="DEXHc_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044762">
        <property type="entry name" value="DHX8/Prp22_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="205"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="512"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="693"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL31326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1164" mass="130822" checksum="32CE9BD939DD7317" modified="2018-01-31" version="1">MADSDLYNLEFLSLVAKITQEIDNYTGLNDKTLAEFVISLHDQCKTLAEFKGKLQEVGANFPESFIENVDRLILTLHPKHKKKPAGKENAVTDGPILDEADKKKRLFPGLALKDQEWEPSVPKDAIMKEVDDMMSQLEGAAKRTRPRTPEDDRSLKRPRRSRSRSPPPPPRRRSPSPFRERGFDERRDDRRGRGGRQMDDRPVLFKIYDGRVNGLKEFGAFVQLEGVAGRVEGMVHVSNIQQGARANSAADLLSRGQSVKVKVMSLAGSRIGLSIKDVDQATGRDLTPHLRIKSEAELAEEEEKRAAHGANAVPLNSRGAKEEVVRSAKRLTSPERWEIKQLISSGALDASEYPDLDEDFANPHTRAEVEEELDVEVREEEPAFLAGQTKKTLELSPVKIVKAPDGSLNRAALAGASLAKERRELRQQEANEQADSEARDFSAPWLDPMAKDTDRVFAQDLRRDLRGQKAGEQAGWKDATFNKATTFGEITSLSIQDQRKSLPIYKLRNPLLKAISEHQVLIVVGDTGSGKTTQMTQYLAEEGFADKGKIGCTQPRRVAAMSVAKRVAEEVGCRLGQEVGYTIRFEDCTSPETRIKYMTDGMLQRECLIDPDVSQYSVVMLDEAHERTIATDVLFGLLKKAIKRRPDLKLIVTSATLDAEKFSKYFFGCPIFTIPGRTYPVEVLYTKEPETDYLDASLITVMQIHLSEPPGDVLLFLTGQEEIDTACEILYERMKALGPKVPELMILPIYSALPSEVQSRVFEPTPPGARKVVVATNVAETSLTIPGIYYVIDPGFSKQNAYDPRLGMDSLVVMPISQAQARQRAGRAGRTGPGKCYRLYTEAAFRNEMLPNSIPDIQRTNLAHTILMLKAMGINDLLSFDFMDPPPAQTMITALESLYALSALDDEGLLTRLGRKMADFPMEPPLAKMLIASVELGCSEEILSIVAMLSVQSVFYRPKEKQGQADSKKAKFHQPEGDHLTLLTVYNGWKASNFSNPWCYENFIQARSMRRAQDVRKQLLGIMDRYKHDILSAGKDYNRVRRAICSGYFRNAAKKDPQEGYKTLVEGTPVYIHPSSALFNRNPEWCIYHELILTTREYCHNVTAIEPKWLVEVAPQFFKVADANKISKRKRQEKIEPLYNKYEKPDEWRLSKVKRSARSSQTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDK8</accession>
    <name>A0A2G8SDK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDK8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDK8"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="703" mass="75386" checksum="A1422303035D2245" modified="2018-01-31" version="1">MATIALKQASAASPTLQDAQTNALLTLLNLNNPHDPSSNASQSSGKGAASLKVASSSGPPVWKVLVLDQYTKDVLATVLRVQDLRDVGVTLHVQLHSNRPPLPDVPAVYFVSPNLANIRRIAQDLEKGLYESYHLNFVEPLPRALLEELAAVVARDGTGELVEQVLDQYLSFIAPSPSLFSLLPPPNAASSSQPSATGPSPAPQTHYAYNLLNSPSSTEQQIEEEIERVASGIFSVVATMGHVPIIRAPRGNAGEMIAKKLEQKIRDAVLSSARSHSASLFAQDASGLSNLQRPLLLILDRNVDLVPMLSHGWTYQALASDCLDMKLNRVVVSQPQKRSYDLDSKDFFWAKNAANPFPQVAEDIDTELNKYKQDAAEITRSTGVSDVNDIAQMDLSANAAHLKTAITALPELTARKAVLDTHMNIATALLEEIKKRGLDELFSTEEAISKQTCQALLEFLRHPKGDAAPTPTDKLRLVLVWYLSAPDSAISRDDIAELEKELKAAGADIAAFDYVRRTREISKMMAPSAMGGATTPVPVNSTPGGELFKGFSALGNRLTDRLKDGGLENLISGVKNFLPANKLLAVTRLTEALMDPSAASNQSLQETDDYIFLDPRAPRNPNAGLGISGVGAPGTSGPGSGRARRMAFSEGIVFVVGGAGYVEYGNLEEWAKKTGKRVTYGGTEIVDPGGFVQVLEALGKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDR7</accession>
    <name>A0A2G8SDR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDR7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDR7"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF83">
        <property type="entry name" value="(3R)-3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="153" mass="16268" checksum="39C76DB0FD13A943" modified="2018-01-31" version="1">MPAETWERTRQVNLDGSFYITQAVANQMKNQTPQGGSIIGISSISALVGGEYQVHYTPTKAGILSLMQSCAVALGKYNIRANAVLPGTIETDINREDLSDVAKRDGMVKRTVLGRLGAPDDIAGPVVFLASDLAKYVTGAQILADGGLFVNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDX0</accession>
    <name>A0A2G8SDX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDX0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDX0"/>
    <dbReference type="OrthoDB" id="307899at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13156">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-A SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="15832" checksum="2923F2484F1DF75B" modified="2018-01-31" version="1">MLARRALQGLARPLTRLSSSSTPIPAHEAPTPTTTVPQSPNFANTWSTSQRPRPHQHSSPRFEQTIMELQPNPLSAMEMINKEPIRVVHGRKAVCDGGTFFRFFVFDAYSFLLQEEALSATPRSSSTCYCGLRFEQAPHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEE4</accession>
    <name>A0A2G8SEE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEE4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEE4"/>
    <dbReference type="OrthoDB" id="3251638at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41994" checksum="85132BE21788A74A" modified="2018-01-31" version="1">MHAIPDPPILVDDLIPIILESDDHWWPRDFQRLALISPAWLSPVRKRLYATPSLRSFRACSLFARALTENPTLLPYLRGLELRPVADGRRALGEEEMRSLRYILGLNGLQSITLGGDLAISAERFLHFMGHTSTVTTLHIDGYVAPDERASSAVHRLPSLEWDDVIAFKFPCLRTLTLSNVALTIYPSASERRGTLSHLTLNNVDIIDGALPDLCQGASETLRVLKVVGTSTVDLDDNILSMLEVCRNLQELHYAAVDKYIHPSIFDSEETPTSPNLQALHVSGFDVNPQTLHAIAQAFPNLVDFAVLGRIIHVLPEQWKLFVQSGKLPRLRRLVTTAGTNAPPFTFWSLDQIAPLQEACRSCGIDLDWGSHPNRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEG4</accession>
    <name>A0A2G8SEG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEG4"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="219" mass="25315" checksum="9493AA56089C656C" modified="2018-01-31" version="1">MGARESTARGADPNNTGPPDYYALLEVEEAASPDDIKKSFRRLALIHHPDKNAHDIEGATDRFAAIQQAYEVLSDEQERAWYDSHRASLIPEPDAAAVFEEIRTGAPPSRARDRGLTVRHLAQFFDTTIWDGFDDGPNSFFTIYRNLFDRLDHDERHYDVTPLPSFGTSAWSWLSPSKEEKDQCVRVFYNYWTNFATNKEFEWADQWNIAEAPDRRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG59</accession>
    <name>A0A2G8SG59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG59"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005545">
        <property type="entry name" value="YCII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03795">
        <property type="entry name" value="YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YCII-related" evidence="1">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="11927" checksum="E7AC1AD16F4500CD" modified="2018-01-31" version="1">MPYFAVWAPDYTDEGAPERRLKVREAHLANAHKNPKIKLGGAMISPNEALDSPDAERKMAGSLIIFEADSYAEVKALIENDVYWKGDVWDKEKTVIRPWVSAKALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SII9</accession>
    <name>A0A2G8SII9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_04205</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SII9"/>
    <dbReference type="OrthoDB" id="3359595at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553558" description="TM7S3/TM198-like domain-containing protein" evidence="6">
        <location>
            <begin position="34"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="7">
        <location>
            <begin position="99"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="41999" checksum="67D2A244E725C2A6" modified="2018-01-31" version="1">MAGFLRQNILTSYILTLLSWLLLLLAHDINVRASPVAGGLLRHGADSATQYWKRVTPVVVSSQVGDNTTVLNPATNQVIAQGPGTDGGGSSLPAIIWLIFVFVVGIPLALAGIRLWRFTTGMVVGLGLTVCVWAAFVNTVSSDGLSDILLTVIAIAGFAIGFLVGMLKFGRWAGVLLLGVLGGFSVGLRIVLLRPGLLVPDYRLNWLILSVFMVMGLSLLLLWQHFGISTCCAAVGTFLIGLGIDLLMEKQDGMSFALRFFFDRNNSHFLAIVNKGYNPSRMTQIVLGASIGAMWVSVSPLPLLTVPLPTPSIPPRRHPTPTDPELTDYIPRSPVLGFAQHKIFKGPFHPESPPGADLNSLMEPEPELTAEKPRVSRMHLLRSRFSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIK9</accession>
    <name>A0A2G8SIK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIK9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIK9"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051848">
        <property type="entry name" value="PGIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059:SF30">
        <property type="entry name" value="OS06G0587000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48059">
        <property type="entry name" value="POLYGALACTURONASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="56321" checksum="C9F16A4E5BBAFE28" modified="2018-01-31" version="1">MSPSTPSIDSKYEWDRNASRPAPPALTVPPPDYPVEVSHFSPESHRSPNRSHPQHARSRSDWTNTTTVKSLTNDPELGKAYPPQTPRTRDRLTKFFFDLRMPTRAPQQEWLPMQEPPLQAWAPLEGEKHHHTHCEHCRKRNDRRRRNKVLFFALGILLLYLLGNTIFLNVRLVRLSQPSTSTATPTAVTPANASTSSVLSADAQSCLSQFALNAPSSPQSYPCSSCLSVLQDVPSSFTSSNTQDAQQLVSAVQFCGLRSIFETANSAGQSGLSTGGWVKDVRFCAWSGVQCDGFGRVSSIQLSFPNVPARIPDEVTALTGLTSLQMIGDTNIPAGDLPVAFNNLTALATLYFESTAITTLPSTVLTSLSKLTTITLVKNANMTGDMTPGLASLPLVNLVINNQPLPANPMSALLSSSSASPALQTISLTEFLSDLSSTSLTGSLPSDLSAFTSLVELHLDNNALTNPLPSKFPSTLQALTLTNNTQLQGAIASGTSFCALSQLKTCDVRGSGLSAQGGCGVCQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ25</accession>
    <name>A0A2G8SJ25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ25"/>
    <dbReference type="OrthoDB" id="2653987at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="310" mass="33889" checksum="877F0E1A04BF119B" modified="2018-01-31" version="1">MFKSKANAGASILPVADQGRAYLGVRATGNPSTQEDALKQALLAVVQLWEDRLQKEGVLTTFFITIDSLLFSLASPTRSADLHGWSVRDQVINASLGGAIIFHVCASIVAYSASFVLIKYQLNDAEKKEEKYFPTSPDLSRAPSISHRTPQSSTEKPERPRRKHTSHSHRPSTSQGSHHGSSNPIETITDFPLEVFTDLRGLVSMDRAHPFWFLSCGRRPRPRDRDEEQVRARSRGDPEAMVGHTAARLKDMIDVLSRAHVVCAGMALVGFVLALLGILTYAWTAVPLALSVFASACLGVCVIAATVALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ91</accession>
    <name>A0A2G8SJ91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03552</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ91"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ91"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="152"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="6">
        <location>
            <begin position="428"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="58463" checksum="BDD543FB8AC01FAC" modified="2018-01-31" version="1">MYGTDRKVEQASASASASPRCPKSNKHRIVGRPNRRAQTLLVAVAVAVTAGFPVAAGLRDVNNALYNTVCQGNLATADANSTSTAPSNSTSDFDWLSLKPSTDIQWTSCYDGHQCARLLLPLDYQSNGTSNATTAIALRMIPARNRTNYRGTVLMNPGGPGESGTLYMGLLGPSLAATVGDSFDFLSFDPRGVGASTPRLDCVTTSSERDIWNMQVGNQLLDASDVSLLNLYVARAQLVGARCAAASALNEDIAQYMSTASVATDMLNIVEKLGQEKLQYWGFSYGTILGQYFAAMYPDKIERMVLDGVYDGNNYRASLWNSNVINNEAVIDSLFTFCHQAGPSGCALYDSTPDAIRDRFFGVLESVKHAPVAIPLATPPLVVTYLDLIGMINIKAAPAPAAAAEQLRHAARGRGYAAFFADITRVAPTVGALWAVYHLECTQWPVRPKWRYTGALAGSPAHPILIVQPKFDPAGPLHDALEVRKRYEGTGLLVQNSYGHTTPSAPSACTARYVREYFETGTLPEEGTVCEPDVLPFVGAVNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJI2</accession>
    <name>A0A2G8SJI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03636</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJI2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJI2"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="408" mass="43332" checksum="A9011226C85A7D11" modified="2018-01-31" version="1">MSSSLSAQPRIAIIGGGLGGLALLLTLHRRGVPATLYERDPAFDARAHLGGSLDLGWKSGQRALRENGLQDAFDNNSRPEGEEMRIYDGAGKLHLQLGEGHHARGPSKGKEDIRPEIDRTVLRKLLLDAVPPDLVQWGHALSSVRALGDGTHELSFTNGTTIACDLLVGADGAYSRVRLLVSPAVPEFLGVNGAEISLAPETTQLPALAETVANVGKGTMMAMQDSHILGAQVNGDGRIRTYAWFRAPASWTIPTSDPGAAKAVLRERYAGWPAWMLALVDRCDESAIYPRALWTLPVGHKWEHVPGVTLVGDAAHLMSPFAGAGANLALLDGLELGLALADLKGKGKLGEAGAVSEAVKVFEENMCAMAGRVSEKANANLEVCVGPDTPQAMIRRFKEVTAEGEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJK2</accession>
    <name>A0A2G8SJK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-xylanase</fullName>
            <ecNumber evidence="12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_03603</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="12"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJK2"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553561" description="Beta-xylanase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="14">
        <location>
            <begin position="37"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL33897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="305" mass="32130" checksum="B8E4AA85BDE51747" modified="2018-01-31" version="1">MHLSPFLALLASAALSAAAALPASPTLEPAAALPTATSTVAGLHALARSAGKLYFGTATDNPELTDAAYVAVLDDAQMFGQITAANSMKWDATEPEQGVFTFTQGDQIAALATNEGRLLREPLNDDGTFRQDVFFDTLGEGYIATALRAAKAADPNAKVYINDFNIEGTGAKATALKNLITSLKSQGVPIDGVGLQSHFIVGEVPTTLVENMREFVALGVEVAITELDIRMTLPETAALLEQQKADYQTVISACQAVPQCVGITIWDFTDKFSFVPSTFPGQGAACPWDANLIKKPAFDGIVAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJY6</accession>
    <name>A0A2G8SJY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_03564</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SJY6"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="1327"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="3420"/>
            <end position="3755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="205"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="755"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1003"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1365"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1439"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1809"/>
            <end position="1847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1871"/>
            <end position="1915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2134"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2380"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2562"/>
            <end position="2672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2815"/>
            <end position="2845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3053"/>
            <end position="3117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="756"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1011"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1057"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1369"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1387"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1441"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1453"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1813"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1836"/>
            <end position="1846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2134"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2148"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2194"/>
            <end position="2281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2290"/>
            <end position="2305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2562"/>
            <end position="2608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2609"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2647"/>
            <end position="2660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2824"/>
            <end position="2841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="3060"/>
            <end position="3086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="3100"/>
            <end position="3109"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="3722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL33858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="3755" mass="410778" checksum="C8E79078666A57EA" modified="2018-01-31" version="1">MSIHPPPKQLPQVAELINKLLDTPNDDLHEVLAEIESWKWPRSDLNAWIKVLNKFDGILEEAIRDYDIDNLQVNVFTPLTKKTVCEILRFERLLLENSTNRKTFNSYDRLNSFMFSSDLDILILALNLLLRPAQQYSSQPAVSHALSISTPRLTSLAKRWPNLREYDINLVDLGTEKGRAQVEALPTEAREVNFVFYRQAASNATGKDEKKETGTEGDVFGSAVQTPRKPSSAAAASAPASTSSGAVTIHIDNKTIESKSAMDILADTIEAHNVPDNEKFELLMRIRGAQALTNAHSGDREKLVVVRLLATAIFGHTHSDSQAQSSLFLYEPDLITHIAELLQLDRGVDIQVQTGAVAALDAMSRYRSKIQDVLTAVNAGVNHGILMALLRKTVSDIAQPTSTLPQAFVEALFSFITFLATHASGGNMIVGAGLVPILIQAIENRLPNRLYLVSKTMQLLDNVLYGYTNAFTLFCNARGVEILVDRIEHEVNFDIEEHAVEDTPDGLVASYGMSPLLSLLTRRLTCSTGKLSVARTAVLKHTLRSVHRMMQSSGTAEGLRGLLDSSLLKSVKKIMQHRAIFGPSALALAINIMAIFVHNEPTCLPVIQEAGLPEVFYGIIEKGLEPVIEVIQSLPNALGALCLNQAGQDQLTARPDTIPSLFSIFTSEDHQRVLQEKENAVLIGTSVEELIRHHPTLKDKVFSAIKTTMARIEELGTSYIVPDDIKLWYRLQPQTPTPAPAAADGAEETVAMEVDPVAPSSEPAASRSEPQPSAEQSSHRDDFWGRSHDNIIISYIDVFGKFLEGFFQHVPHCRDFVADTEGLDRLAKLTTLPCLPYDFANSVASDSLVQVVRTMAEAATTETLTYLVKLVQDSLEDCKDFWETMDEQPKLMNMIEFSSGEEEEKANAKFRKLITLHTRTSLLSDIYATAGYSHGRATQTLLQSLLTRSPNPLQDLGALHRACVWENIVLKIVLSSRGIDFTPSHDLLSSLLGSTNAAVQELTSSTTSGRANASSPSTANGASSSTGAANGAAPVSAANGPAPTEPSTSTTTPHAAAKKEDQPRDKNAKSLKHLVSQIPSALAPFFQSIVRLFQTRRSSDTSQKQKIKEAAGIIAEVLVKHLEQKPFSDKLALFAYYTSMLNATAILLVDERPSQKTLHTMLLVAFVRLGGLDALFGLCREFVNSIEMISKVNAEQRTEATKQELSHAFTGLRVALGLIQPLISARPLFESAQTPLALTTDKKDTDADYFEPHNFLVRMRATSLPVVRSIWEAEWLPSAPIGVSKLVVHIVMELLNAENEEIKDVQTSASILGGGAIGIPRIPAMATPDENGIRQLTDMGFPRSAAERALVRTRNNVNAATELLLSHPYPFPPDPDPVPEAAPIPAEDGDEDDEGDGEGEGEAAAVVAAAGGQEDAIQADAPEAGPTVVGDVPADAHEDAPAQAATGGTSETATEEATEEAMGDGASTTADQEASVVPAVEEPPAPPGKTSEEWAKELNAAREPLKEGIGRRVLGLVDEHSSLVFDVQKVFIGPSSEYRTQAVKALIDDIQAFSQSAYDVQEQPLSVRCHLLALVLGEPTSPAAQMQEKEAENLMNVLVSLLLSNPGEGGQPTIPKWLPAQLLVIESLLVLGDSPRSVTLPKEDEPINREPIAQGPRYAEARTTLFEFSMRLLGVPTLPKDELISVLRLIVLLTRDGNIAEAFVKRNGVSSLFQYLRVSSGTQSATGIQSYIAIIVRHVVENQNTLQHVMRQEVKRFFSHPRTRVVDIGAFVSGCNSAALRDPQAFVKVTEDLCQLSQPYSSMKMISLKRETTPSPASQSATSSGDKTNEMQVDEPQSQPASSAPADSTEGLIHYLIGELMKTVKTDIALESSTGPAPGDTPKPPSSDTPVSSESRAEGAPSATEPEPKAPQEPPDYTYPCFIMQVLTELLFSYESCKIAFLSYTPKKRNQTPAKDSGVKHRTAAIQFLLSDLMTFGTINPQPPSEARKQITLCNWAMSVIVALCVDTMTMQDIKDVPTDLVSVRKFVLEAVSRALKDLPSSDSPEARYSRLLALSDLCHRLLTVRFNASGKKAGDEAPTHVAKIMLEKNFVATLTNVLSEVDLNYPNIRNVVSSVLRPLEHLTKIAMKMSRVSDKNKELVEEKVETSESDVSEEDEEGEDETEGPENEEASHVYRNSSLGLFGGEMEDVHYGDEDDMDEEGEDDEDDDVEMDFGDETGSEDTSATDEEDVEEDLEDGTGESEEGWHDEEDEDEEGLVENEGEPVEEEADEEEEDEGEEVMWQDIAVGEGDADEGADEGDEDEAGDMPMAPMDMDDEGDVISEGEEFADELGLIDEVHNAPNLLNFAANFANALGGTFAAGLGGVPDGEPVVWTGAVRSTRRRGAGDDDLEIFGRPRNPPPPSGENVTHPLLLDPATHAARSAQARSSRRGNRGLLAGAGIDLPPGLDQALGEGATQLLQQMLIHGRTLGHEALHINVPAGILGTFQRNGRAGAISASIRLERAPRPTDGRSEGRSLEPLLTVQRWAEEAKMLHGKFEQTRLTKLHNHVILTLLPAAVEAHKKAKEAEEREQERIREEQARAAEEAAKKEQEAVEAAEKAKREEEARAAEVATQAAAEAEANAAAAQEASVTADTDVEMADESSTSPAAPAPENGPENAESSAHQEDAPAPAQERITVLIHGEPVDITDTGIDPTFLEALPDEMREEVLNQHVRDQRAAQLERPADSQISAEFLDALPPDIRAEIIQQEAAERAQRTRVEQAAQQGGPIEIDPADFIASLDPQLRQVVLMDSDDVFIQSLPSHMIAEANIHREHGRPARPRHVAPGQAPAPGAPHQASQAAKVPQPRDAIQLLDKSALAALVRLLFYPHILKKNLLYKVLVNLCENAKSRTDLFNLLLSILQDGSGDLASIDKSFAQMSVRHSKPTAPQTPKAIGKQRVSTDYFGSLSLPQNDVVPELIVQRCLESLTYIVSSNELSSLFFLTEHELPIGLRRSSSKKGKGKEKQAPQTHYPIVLLLSLLDRPSILRTPSIVESVVGLLATVTRPLASLKDIKKTENAESSTTGTSSAPSAQPPATTQPVADTQPAEGTDVAAPAPPSAQAPAPSTAQPGAPPKPPATVEEKVLLANPPHIPHHVLRLIVNVLTAGECSGRTFMQSLSLIQHLSYIPDAREVVASELRSRAQEFGQSLYTALDELAIALRDADAQPDALATTIAAKFSSASSDQAKLLRVLKTIDYMYSPKTSGNSTEADIEKVQGIYESFRFSTLWRRLGDCLSIIEEKPEMEHIATVLLPLIESLMVVCKYVGPKTTSGAAVRALRASTSPRSPTSARESMEDLFVTFTDAHRKVLNLMVRNNPSLMSGSFSLLVHNPRVLDFDNKRNYFNQQLHRRPHNREHHGTLQLNVRRQRVFEDSFQYLQRKTGEQIKYGKLSVRFYDEEGVDAGGVTREWFQILARQMFDPNYALFQPCAADKLTYQPNRASWVNPEHLSFFKFVGRVIGKAIYDGRLLDAYFARSLYRQLLCKQVDYKDVEWVDPEYYNSLCWILENDPSPLDLNFSVEADEFGVTKLVELKEGGATIPVTQENRKEFVQLSANYRLYSSIKEQIESLLAGFYEIIPKDLVSIFNEQELELLISGTPDIDVDEWRSATEYNGYTSSDPVIVWFWRALKSFNREERAKVLSFATGTSRVPLGGFVELQGVQGTQRFSIHKAYGDTDRLPQAHTCFNQIDLPQYSSYEMLRQQLLLAINEGGEGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKM3</accession>
    <name>A0A2G8SKM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKM3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKM3"/>
    <dbReference type="OrthoDB" id="2690066at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="927" mass="99310" checksum="EE4DD3768FD29E94" modified="2018-01-31" version="1">MNSTSPAPKARPQRAPDPTADRSSVLRASILESALELGIGSNRTVANWIFNTVEEGDEEDNTGIVSPSLTYASTATSASEESNLSVGRAQQQQQPPPQAQPGAGIVIQVNGQPDGKDTLRLNLDTPPLQYSQRNGLSPAYLTPDGTQRTLQFDLRASPEPSRAISPAPSSQTSGTKNKLRKPRPDGYESDGGYMSEGGKGKKEKEKKEKKSKKKGKDKDGIGGGEGGGVTDYESDGGYLSEAGAKRKKSKKEKKEKEKGKSKAKLAESPATDYETDKGYTSSFTRSLSRKQSSITSPVSGDESDGGYLSESSKKRRFFRINSKSRKKQDSLDSVQEQPPPVPALPAVQLPIHEKFSRATSPLPRDGSIEARPSVETVTSADTITSADTTTSMDTSLTLDTTSTTVESDEKRESPSSTEGGLTRAFADAESVRSPSIDLLSAFRRPAGDSRPSSPLSPSKFNPFTHGLRPTSPLSPKSSAVPALSPSKSIRARPKISAPNTTTLAPKHIPVPLTLTPPTPTTFRYPSNQIPPSPDGDYVLVTPNPYTTFSAEPSSPNGGPAAAPPPSPKLQRPKVLAYYDLPPPSPPPRGPLPDVPQDISRSTSPSWSVAESSRLSRSAPADTNDPRNIHQQRDVPIALPPHHPHTAAHPLSREITGAGIHDVPTIAQPVPPTQRGRVSPFPTAPLLPREQTTPLMRKTSTKTREAVNRALNHNTPASASPYVEGHGHWMSHDQVHGPTSAQLYPAQGSNWPSGRHVRFAPPRSVSAMDTRRPDGDGSSSDDGRSWLVYDDDENGAASDQSLSAPATRPASAEPASPDVNAILAGFRAQRDAELSARKDLSQRRATQADTLAGIIAGYERETMYLDVEEGGADRASVWSEANSRHSFLDSEKSAAIREKFVKRVEAMYGKETVPPMPRLDSGLSSRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLG7</accession>
    <name>A0A2G8SLG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLG7"/>
    <dbReference type="OrthoDB" id="3222645at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="429" mass="47487" checksum="F58FEA08A6862418" modified="2018-01-31" version="1">MPPSGSFISFAAAACKIALVLTTFGYAGVVAHRMRTQNAQLQKAVDEARAERERLIQQVALERSRAESVVEEKRQESEFWRRMEALARSELRNRDKAVEQEGGPARSSSREVTEDSRLSDGSPALRAQVADVRSTNSSYDDIVLAMVRTLNFEISEVASQVTNAFRVADEPDPEKVRQAFERAREAVGPVMAELLESIQHQDDPILIDIALKADMVGFAAEVASAWDFQHQSKPVFTGLYKQMRRSESQLVSGQWRSRARKYSKQRLYNGRDLVPGFSQQLAERIADLLTVAGGSFVAEDIHAQYTQHLDTIIRTALDLQRIIGEEVVECDYEVLTSHFDDVFDPEQMEDIYNGEIAATGPPGTVPRVLSTADLGLRRSEKVSGAHSDADDGLSVTMLLKPKVVLDTVVYELGLVDEEDASPSTVGPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMD7</accession>
    <name>A0A2G8SMD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMD7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMD7"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="138"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="484" mass="53964" checksum="3C993A2BB2BB0181" modified="2018-01-31" version="1">MANVEQLEDVNHQETFRQPKQLQHLRSSIVAKPPYCQGTLALPQKDFTLFYGTEGDAQRINLSRASAAQLQHLADTCAPASFGVGGEDIYDETYRKAGKLDCEDFAITFDASRSCLADVIRNELLVENPKKVKSEDLNIELYKLNVYGKDAFFKAHVDTPRSELMFGSLVIVFPTPHEGGALKLRASGHEEGENPEWTFDSSALLAQQEQPSIAYVAFFSDVEHEVMPVTSGHRVTITYNLFYVPAESEPPEELTSISTNEQSFKNALQAALEDQSFLPTGGNLMFGLKHQYPLATYYCEPYNPRDEAAREKKTQAMEARAKRALHALEPRLKASDRVIFKVLRECALDTSLKILHEASDGDNPEAVEGYVMADGVLPMPTTRYGIGMYASEYVAEQGGQLVEDAVVLMEKQAKWGQSVGYHLEDHGAPVYWVDHPRLRSGKGFKAKFATYGNESALGVVYWSVWIFVRIGPAGQREMAQVSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN34</accession>
    <name>A0A2G8SN34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_02975</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN34"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN34"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="561"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="244"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="352"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="524"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL35185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="633" mass="65647" checksum="CBBDA3267238EAFC" modified="2018-01-31" version="1">MSSLAPPSPSVSPAPGGRSPNFRASMGPTARPVGVQGGLSPASPRPGATNGGARPTSELLGSAGMFQTPEAEAIDQWFETFQNYEVTLEEMAAASLDVNFKEELSAIEQWFKVLSEAERTAALYSLLQHSTQVQIRFFITVLQQMARSDPMTALLSPAMGGSMQSQMEAKLASMNMKSPGLKSNLPASPTARNFSGSAIGGSNFLSPESANNAGDAAATLAQQRAKLKASNAAHRISAPALSSTLGADRNTWGTGSNQLGQVDERSSSPAQEITISANPASRPKSTDFSGLANALKSPRGEEGDQLSPMPGGSWASMVNTPLIPIFKDTRNPGQSLDAAAQKLNDWTASGGAAVPLISDPPKKFNRLSKGAQGNNDGEEHQGQNGGNQRNVSGGLRSGSNNGNLSAFGGQAGWGGARSPALSNTSGRFSDDGSMNGLGMAGFGAMGMGNPGLAGLSSTGGFNMAALAAAGMAPVSPFNSMFNMSNLAAMGLTPEQMLAMQMAAAGQLGQLGQGGLSPFGMGMGNNGNMRGNRGMGRGGNSAKSSPLPRTGEKKDDEDVDPKLLEDVPAWLRSLRLHKYTPNFEGISWRDMVLMDEAQLEAKGVAALGARRKMLKTFEVVRKKMGMEGPASASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNK4</accession>
    <name>A0A2G8SNK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02066</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNK4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNK4"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="13">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="11">
        <location>
            <begin position="180"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="12">
        <location>
            <begin position="452"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL35341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="554" mass="59787" checksum="7E795D41B08EAE67" modified="2018-01-31" version="1">MAAQLPVPVFTSLDQAIPDIQTAAVQAVRYSQLVEEYEKRFGHKPTYIARAPGRVNLIGEHIDYVLFGAFPAAIERDILIACGPSLSSESGATETSAPGGVRAQNLNPKYDPQTFAPMLKSAGPSAAEEADAASAVHAEPAWHLDINTRELRWESYIKAGYYGVLSRFFPAALAGSDKQDHPVPVDLLFTGSVPSGSGLSSSAAMVVASTLAFLTVNNKLDGVTKGQLVEMAMENEKRVGVNSGGLDQAASVICTPHSALYVTFFPQLGAELIPLPTPRTTPRAVFVCANSLVVSDKVVSAKWHYNLRVVETLVGARVLANKLGIQLGPADRPTFREILSRWLGTPESELDTDALKVGIERFLPEVEKLRPGHEGRPAGEEGVTMQEMIELSGLSAEQFHKVYLSWVEVEAEYFQLYKRARHVFTEALRVIEFRDVCLRANASSDAPPADTLQQLGALMDASHESCATLCESSCPEVDALCWLAKAAGAYGSRTTGAGWGGCTVSLVAEDRVEEFIGKIKEGYAPYRELEGERLREASFATKPSAGAFVLKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNN7</accession>
    <name>A0A2G8SNN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNN7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNN7"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="106"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="39884" checksum="1AEA8794210BDB0B" modified="2018-01-31" version="1">MAVETEVIYETRPPPDIPFDPAVLPPSLKLTDAHQKLYDEVLKHFDREEYVLPGVEDGALTEEEKFWLSAESMLRFLRAVKWASAQAAIKRLEATLKWRREYGLYDVITASHVEPEALTGKMVLWGYDADNRPALYLRPSKQNTEESIRQVHFVVWALERLTELMGPGVETLALMVDFSDRAKNPSLTQSRAVLNILQTHYPERLGRALVVNVPFLVNAFFKLITPFIDPLTRPKLRFNPDCVGEGLFDASELLSEWSGGSAHFQYEHDRYWGPLVRLCAEKREKLWTEWRALGGKIGVREWDVKTRIELAEAEKVEAKVGTPIVVQAEETKAPVKEEKGNEETESPAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP24</accession>
    <name>A0A2G8SP24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02255</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP24"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP24"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="4">
        <location>
            <begin position="273"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="372" mass="41245" checksum="36D8892108D7E63C" modified="2018-01-31" version="1">MASRPTVNVRSTSGEASTSLPLPAVLTAPIRLDVVQQVHKSIAKNKRQAYAVNVKAGHQTSAESWGTGRAVARIPRVGGGGTHRSGQAAFGNMCRGGRMFAPTKTWRKWHVKVNQNQRRFAVVSALAASVLPSLVLARGHRIEQIEEVPLVVSSQSESFTKTKEAVALLKSLKAYADVVKVSNSRKLRAGKGKLRNRRHRQRRGPLVVYNEDKGIVRAFRNLPGVELVNVRRLNLLQLAPGGHLGRFVIWTEGAFGLLDEVFGTFDKASTHKKDYILPTAKIANPDVTRLINSDEIQSVVRPANAKHQKRPWTQHKNPLVNKGVLFRLNPYAKTIRRQELLKQERVKAQKAKKKAKAPKAVGETFLKTFFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ97</accession>
    <name>A0A2G8SQ97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ97"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ97"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL35947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="386" mass="40803" checksum="28C3248050BF2CC7" modified="2018-01-31" version="1">MVSFQCDGCGDTVKKPKLDKHYQMCHAAVTCIDCFSTFNNPGQFKGHTSCISEAEKYQKSLYKGPKTGQQQNGGGPRGQGQGQNNRGGSQYGGGRQNGAGGGGKYQQQSWGRQGGGGWGGPRGGNEASGANGTPLGTPVRMSPVTVVAAEGESPETNGKAADASANGVKAAEKEESKAKDGAKKDKKDKKRKSVGGDEATTETQTGEQPKKKKAKTSDSPSSPAELAADVPSEKSEKKSKKEKRDKKAKDVPSDEPVASSSSTPTDGEVKKVKKSKKEKKAKSEAIVEESAEVAATNATESAAGQGKPKKRKREEVDELEAPPPAGEGKSKKDKKDKKAKKGEDTEDTAERIDVDGETKEGKKEKKSKERKEKKDKSKKDKTKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQB8</accession>
    <name>A0A2G8SQB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional coregulator SSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with transcription factor HSF1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQB8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQB8"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL35969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="568" mass="62914" checksum="9D02A17CD3425E55" modified="2018-01-31" version="1">MTKAVGIDLSTIYLCVGVLQNDRVEIIANDQGNRTTPSYVAFTDTEQLLGDTAKNQVAMNPHNTVFDAKCLIDRKFSDTEVQSNIKHFPFTVFDKAGKPYIRVSYRGEDKEFSPEEISSMVLVKMKEVAESYLGGTVTSAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINESTAAAIAYGLDKKTTGERNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRLVTHFSQEFKRKHKKDLSGNPRALRHLRTACERAKRTLSSTAQTTIEIDTLFDGIDSDFYTFLARARFEGLCQDLFRATLEPVEKVLGDAKIDKAQVHEIILEPPKSINPNDAVVYYGAAVQADILTSDTSEKTLALLFLDVAPLSLGIETAGGVMTPLIKRNTTVLTKKAEIFSIYSDNQPGVLIQVYEGERARTNNLLGKFELSGIPPVPRGVPRIEVTFDMDANSILNVSAADKTTGKSNHITITNDKGCLSKEEIERMVSEWRRTRRRMRRRRSASQQRSGLESYVYNLRNSLTDEKLADKFDPVDKTKLETAVNDTISCLDSSREASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQZ4</accession>
    <name>A0A2G8SQZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQZ4"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="284" mass="31510" checksum="E20A09090D7ACB8A" modified="2018-01-31" version="1">MNLTPGQSHEAYIGPPSEPIKVSDFLDTAQELEEGSEGSPIPVFAQSSAALSADIRTLWTSLPEAEREKIQLECRVDNLRNELEDTICNPQLMAYTKRVHDAAVHAIYETAETTRKKRKRTTVADPESEVPETTALRLKHEAIRLKCWPLTIVAASFIRPPRQPDHNTLIDVKKLSASQAKDNDALLFITVYNRLSWGQKFLLRASQHVLLSSQSLGELFDAIPCTSKEIPDETLDEASVFIGYKVPGSEDSMALDGGFGAAFCIEGVLYADAVDYAEYRLTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRA3</accession>
    <name>A0A2G8SRA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_01934</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRA3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRA3"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL36272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="229" mass="25277" checksum="80DBA908CAEAA490" modified="2018-01-31" version="1">MALDIVIPILPFEKFIIAHAVLCVIGFLGLLPLGALVARYTRTFSPNWFKAHWIIQFAVAGPVIIVGVSMGIHAVVLAVSGPVNDVHKRWGISIFVLYLAQLAFGASIHFYKPSAWAKGHGRRPYQNYFHAVTGLLIIALAMFQVRTGFRSEWPVQTGRGPITNGANVFWYVWIVLLPVIYFSGVVVLIRRQLAQEKEAREEDTDSAEPKEPIAHEASGSTATEVAKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS18</accession>
    <name>A0A2G8SS18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS18"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="22310" checksum="1EB23366B7C3E81A" modified="2018-01-31" version="1">MIPQSLQPKVQVWPLEQYMLTLNQNWGYPFHFGVSHKEPLKSQKKKEDQAELECQKLAKILIGMMNLMLEPLESLVNLKDLEDLEDQEVVDLEAEDLEDQVVEDPEDQEAENLLDLLEEIQTQEAILEVLGLDYLWDLQYLTLHQMETRLRSKHLKHLMEIETSCKTSLINCFFSSWETLPNTSQAIQTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSF9</accession>
    <name>A0A2G8SSF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSF9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSF9"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="221" mass="25061" checksum="09C553F2F95A766A" modified="2018-01-31" version="1">MGLRLGDTAPDFQAETTKGPIKFHEWVGNSWAILFSHPGDFTPVCTTELAEVARRAPDFEKRNVKLIGISANGLSDHEKWVEDINDWGAQYGPTNVQFPIIADPDRQISTLYDMLDYQDATNRDAKGLPFTIRTVFIIDPKKTIRLTIAYPASTGRNFDEIIRCVRSLQIGDKYRVTTPVNWNKGDDVIVHPSVSNEEAKTLFPEFKIHKPYLRTTPLKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSV7</accession>
    <name>A0A2G8SSV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSV7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSV7"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013627740" evidence="1">
        <location>
            <begin position="24"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="233" mass="25487" checksum="1317780BB01228D5" modified="2018-01-31" version="1">MFSLLWMPSTLLVLATVLVKVHSYVPALPSNQTDNSPTVLEGRLEIGCRSPKLFRVRIGVDLPLTVVLVSCDSNSTNPPHEDIFFRARDLKAVAGVLYSLYSETCVLTPGYNGTDANMPVYLSPSLNASRQVYLPIHAEVLQSIKLAAILVRAIEALFSKVDNRYNTWDSQTLQSEFYNISTDTPKEPNVDPGYLVAQAFWNASDAPASPSPNPSNKNGATAGAIEGYHALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST12</accession>
    <name>A0A2G8ST12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST12"/>
    <dbReference type="OrthoDB" id="2751073at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="316" mass="34812" checksum="F8BF8132882F38AE" modified="2018-01-31" version="1">MPSYRDNPTVELPSTNSWTVAEDNAYFIWDGDSQSFVSFSLGNTSAASDRSWQCETLAQAYAIPHSSPKPVNNDWADEVEEELFTGEPVTFFDVTMPADRSKIGAETCDTVSIAGRATTTTSEAFRADTEAKLDMPRHRSCSTIVEEDSKLEDEDEGDRREPEEEPPKGRDVSEEPPPKRAVADPLVGTGFGVDDLGYPLHACKSPTAAFLENVARDDDVSNLVIVDPETLDGGYVMVDMTGMCVTPEGVEVGKHRDLLRRWKSAMKRGFSNTPILVSSKAPSKYRISNTNYAKHKAQFHSVVCVTVMQSVETVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST95</accession>
    <name>A0A2G8ST95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST95"/>
    <dbReference type="OrthoDB" id="10435731at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="375" mass="43425" checksum="1CFB18FB47C3217C" modified="2018-01-31" version="1">MSTLPVLFREEQQPAEIWFMIWRELGALIDKDFKEVNRRRTLNDRGAPFYSDAHDTLRKDPRRCKAKLAFASAYSIALQEYGLELYEHVVLTTCGAVDAILDCARTSMLRPIWTSSLRATWIKHIDLILSDLECMKLDWEATREAWSAFYRLNTLTICYHPKEPAPLNQFRPIAAHLPPSLRLLRLRPWMEANDIPPQFPQILKGGAKGRILGLRQDFWWDVAWARDLQVFQNVPQIHLQVVVYVVWPPYSKRAAEKAFRGWTSLVNGGRLQNISVTLFPPNEGLDVQEAVKELEGDPLSEGKRHGYFSHDTEDIEDALPNILAYDWRKDRDGHWEVDMNGATARNCARDYGHFSYPVAAELDDHLKWGWYSSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STM0</accession>
    <name>A0A2G8STM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STM0"/>
    <dbReference type="STRING" id="1077348.A0A2G8STM0"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="259" mass="27626" checksum="082C2CB6A589F95A" modified="2018-01-31" version="1">MPPRPTVLLTGASKGLGLAITKILLETFNTNVVVLSRTRGPALQSLVDAHKESLLALECDVTDAAAVGSAVSRGVEKYEGIDGVILNAGVLEPMGKIASDEIPIEQWKQHFDVNFFSLVTAIRATLPELRRSSHGGRLVFMSSGAATGNIPGWGPYNASKAAMNSLCRTIAREEPDVTFVALRPGMVDTNMQTLIRERGVATMPADAHQTFVNVHAGGQLVAPEDAGHVTAALALKAPKSLSGQFISWNDESLKEFRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STS2</accession>
    <name>A0A2G8STS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STS2"/>
    <dbReference type="STRING" id="1077348.A0A2G8STS2"/>
    <dbReference type="OrthoDB" id="2195113at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="482"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="544" mass="59134" checksum="E5B8CD482FC6D614" modified="2018-01-31" version="1">MAPKTKSAAANGANGASQKQKSAIPSGTSSPATVVAEVQEFTPITYGSGRPDKAQYDAEQNKIKAEIDALQVKLNAVRDKLNIGKGGPGNERRNALRAELDTIRGQQSTSKLARGKVFEQLKTLQEGIQKKVKDLNAQKAKIPYKTVSEVDDRIRQLEKQVESGNMKLVDEKRALQEISQAKRSRRIVEGFQADQDAIEADRAKADEIRAQLDDPEAKAASERYDAIKAELDELKKEGDEAHASRSKLLDERTAIQGQLDELWAHKRESASRYKEANDKFYAKLNEDRARRIERQRAQRAEQEEAKKKEIVDRLRDEADVPAFQAQIEDCQTLIDYFSGKSSTATLSHQKPLTEKSDVAGVPKLDIRKVDAAPEGMVARKKKGEDDEAYFVGAGKKKGGKKGGAKPVADANGSESQSANGQLNVPLPTLTALLSLSIPPPTSTTDVPRVVEDLKTKKAWFEANQSRVTAENKAKAEAEIRKLLGGKSNDVEVPPFGDVPPAGGAEQPAEPAPTPATAPVPPTGVPSEAVDEKLEAVQEQATEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUQ4</accession>
    <name>A0A2G8SUQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01184</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUQ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUQ4"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="69"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL37490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="549" mass="59332" checksum="F50701840B8EF2DC" modified="2018-01-31" version="1">MAFYTPQLAAFKVPAVDNEPMRSYAPGSAERKGLVEALAQMEKELPFEVPCIVNGKEVKTGKLAKQPLPADHANHLCTYHEADQATVAAAIDGALAAKKGWEALPWNDRAAIFLKAADLVSGKYRYKLMAATMLGQGKNAWQAEIDAAAELSDFFRFGVKYVEELYSQQPVKNAPGAWNRVEYRALEGFVLAVSPFNFTAIGGNLPGTPALVGNTVVWKPSPAATYSNYLVYKILTEAGVPPGVIQFVPGVPEAVVGQAIAHPDFAALHFTGSTFVFKKLWKDIAQNLDSYKSYPRIVGETGGKNFHLVHPSAEIRNAVTQTVRGAFEYQGQKCSALSRLYIASSVWNGGFKEQLLGEVASLKVGSATDFTNFIGPVIGRPAFDKIIGYIKKAKDAGGEVLVGGTGDDSKGFFVQPTVILTKDPKSVTMVDEIFGPVLTVYVYEDADYEKTLDLIDTTTTYALTGSIFASDRHALVQATNRLRNAAGNVYYNEKCTGAVVGQQPFGGARGSGTNDKAGSISIFYRFVSARSIKENFVGLESHLYPSNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLG6</accession>
    <name>A0A2G8RLG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_15053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLG6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLG6"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="55"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="175"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="379" mass="42347" checksum="3E3E09BECD7C6B88" modified="2018-01-31" version="1">MAIDYRGDPPPLIPANYFKYHLPYFTPQEIERLSEKQRGKLSVTQEEKARQQACGFVEAIGSDIGFPRKTIATAQNLYHRFHLFFPRKDFAYHDVCLAALFVSCKIHDTLKKTRDLLVASYGVRYPERAAKAKSMGGEIDIDPNVMEGDRQRVLAIERLIVETICFNFNTRLPFPYVIKISRAFGATKKLAKLAYRLATDSFRTLVNLQYPPHVVALGCLYVASMLSSFERGTSPERPGHNTAHQIAATLSKSGDWGRQFQAHIEDIEEIAHAIIDLLIGASQNPAASTSPHTPSSPSPHLSHSVGQPAPPRPPPVPYKADQLIRLKIVMRESEHPSRVRESAAAGEDINFNKNDSTLLGRNDKTVRFMFAPPAMVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM80</accession>
    <name>A0A2G8RM80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_15309</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DDB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM80"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM80"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="13"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="508"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="909"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1193"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL22619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1269" mass="137183" checksum="A41AFE11F2D6D931" modified="2018-01-31" version="1">MRVVGTFHPSSSVSRSLKCTLTPDPRVEFLVLAKTDKLEVFSLRPEGLKRECGMDMWGRIVGLQDVPTKEEGRSHILVMTDHPDPKLILLSYDVVDGVGSLTPAGYIALADRAARPAEFVTDFRVDPSGEVIAASCYTGKLKIVTLKDGTLDNTFDVSLPELNLLAFTFLYTEEEGRHTLALLHLNHRQQIQLLCRDVDLGEFELSPAHSHLLLTATLSDKTFPSLESPLLLVPIPSHTSGEEDVEGDDDAPGHRGGVLILGGRKILFYEHSTQEQQDTRKEKQRRLDKRLASEDAAQEAAAKEKEKQRESRRIKPRATVKWPWAAVTAWTAVDEGRRRVILGDAFGRLAMVAFDEGKMCLNLIPIGEASPPTCLSYLSSQVLYLGSHHGDSQLLRIHPTPVANATVDTLPIPAGVSSVPPSSLTGSDKGKGKATAGDLEGSLARDGRVVNTKGTYLEVLDNFDNIAPIMDAILADIDGSGQPQVITCSGALTRGSLRIIRTEADFQEQARLNGLIGVTDIWPVKKHSAEPTHIHLVVSTLEDTHVFAFEGKDAVTHLDPSAAGFATNVPTLALGNIPRREISASGASAYVPSSLIVQITAGGIQLVEYDPALLGFTKVGAGWYPKTLGGEYAEREIVAAAMSPSQFAVGLSGSRGGGGGRLALLNLGPKDILQLLQTRDFPDEICAISCQPYDPSKNYATALAVSFWGSNKVAVLALDSKPTLQVVCDVVLPTLPRSVLLHNFGTGTRPRDPEFHPYLLVGLADGTLVTYALKDGTLHDRKQSSLGNAPASLSVCTIDGRTVVLASGTRSSVLFWDRQRVRPSPVSVKDMIRGVTLHTAAFPSCLAIATSSALLIGNIRGLDKMQIRSTPLGLDAPRRLVYHAGQGVFGVACTRTALNRIGDYEQSTGCFKLLDAHSFKQLHNFLCDTGEEPSSVLSLPTHGAGSSPALVLGTVYIRPEEREPSQGRILLFSVLQTEGERGASVRSLHTLASQEVGGCVYALAHLSENYIIAAVNSSVVLFRATDNIAGELTPLRLEKVTEWNHSHFVTNLVVDGEHILVGDAISSVSVLKWNDDLERLESVARDYGPLWPTAIEGTGNGIIGANSDCNLFSFSLQRTPQRTYVEKDGIYHLNDVVNKLLRGALSSTDVAEDQVVKPSHVFFTSSGRIGTIMDMTDATSLHMTALQRNMAKTLTGPGGDNHSQLRAPAGPRGHTDAESSYGFLDGDFLEQFLTYPQPEQFMEGEVEAERITLSVDTVKDVLAQMQSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMI8</accession>
    <name>A0A2G8RMI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alternative oxidase</fullName>
            <ecNumber evidence="16">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_15217</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="16"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMI8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMI8"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL22528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="345" mass="39633" checksum="6C8CFAF63AF557AD" modified="2018-01-31" version="1">MSSPTRHDQKVLEAKKTYEKSYLGPGAEGPHIKDLPPKILIPATHTTTAEEVRGDWVLFHPVYTPEELRSVEVLFRESRTFSDRVAHAFVKLARWGFDLASGYKHKPLPPNAASMSLEELRKGGYLMDETQWLRRILFLESIAAVPGMVAAALRHLRSLRLMKRDQGWIHTLLEEAENERMHLMTFMTLKKPTRFFRAMVLAAQGVFYNAFFLCYMVSPSTCHRFVGHLEEEAVLTYTRCIKEIEAGRLPAWTDLPAPEIAKDYWRLEPNAKFVDVVYAVRSDESTHRFVNHSLASLKYESDINPFALQEPDMTIKGSRICFEREESAKFAEDARNQITDKRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMJ8</accession>
    <name>A0A2G8RMJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMJ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMJ8"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="172" mass="18764" checksum="F29C382BB1C0EA73" modified="2018-01-31" version="1">MFSALRLTAQVARPWSTSSLLQRAAPSVTRTAIPFAFSRSFHPSPSAATTLNQATRRKPKLRVKPSKSPLLEGNTHKKGVVSQIFIAKPKKPNSAKRKVAKVKLSTGKTVQAYVPGEGHNLQDHSVVLIRGGRTQDLPGVRYKVVRGTLDFSGVVGRVTARSKYGAKRPKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN44</accession>
    <name>A0A2G8RN44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN44"/>
    <dbReference type="OrthoDB" id="2734101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708277" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="14941" checksum="6226B6ED26376F25" modified="2018-01-31" version="1">MKFAVALLAFAASALAQHIQISSPSSFASVKPGSKITVEIGRPNSLTASTEVGIAIGLWPCGGPKGTSRCASTDVSQVLGNVVYTGSYTPAYDTNAPSKPPHQTFEVTVPTSFSKGEVSLGVAHLSLVGAGAEPTYQFANITLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN80</accession>
    <name>A0A2G8RN80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_15671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN80"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN80"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="265" mass="27821" checksum="DD3E0F9C0879CB0C" modified="2018-01-31" version="1">MQPLASYRSALANSARRAPGLLASARRTSPALLRQGPLGSRNSSSTSQEQASPNPQSRSSSSSNAPLAFVLGSALSGAAAYFYATSQADTASPTTAGADLNNKYGSPEDFKKAIEELEQLFPGDETVTTDPIALEEHGMSVNDYHEASNPSVVVFPTSTEDVVKLVKVAGKYKMPVIPVSGATSLEGHYRAPSVGGICVDMARMDKIIEIHAADSDVVCQPGIRWMDLNETLKKRGLPLFFPLDPAPGATIGGMLSTGCSGSAWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RND4</accession>
    <name>A0A2G8RND4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor beta propellor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RND4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RND4"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="2">
        <location>
            <begin position="73"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="212"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="249" mass="27354" checksum="089E8138791006C5" modified="2018-01-31" version="1">MIACAWSPDGALIASASVHGTVRVWDAETFQELGVHENPGSFPRHLQFSPDARYLAWTTTSSIHIWSRPAAEEDQSKRPLVQLKYDAAVNALSFNPESTRIVTAHGWCDGKPEDCVVRIWDVATGAVLALLTGHTAEVWHALFSPDGRSILSIQVGHGGPAKIWDAVSWKETLSIEIDGGRGCFSPGGEYIVTWNAQVKLWRASDGLRLVTFTEHKRFVTDAAFSLNGEFLASGDEDGIVHIRRISNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNF4</accession>
    <name>A0A2G8RNF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNF4"/>
    <dbReference type="OrthoDB" id="2783256at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="143"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="313" mass="34511" checksum="381B161FCB65481F" modified="2018-01-31" version="1">MAQYYQSPVPFYYAVPVVWYVPSKPSSSTSSPIAQSHRRRHSSSSTPDVTSPSKRLLHSPHHSSYSLWPAGVPPTPELRTVPLPGVTSDAYATADERARYPSPVPPHAHGKSAVHQAPHPSLTQPSVDPFLAVLHHPNTRPPIVWDVMRHSSTAVLDHPSLTLDALRQRCAFKASRADGRHPLRSLVLIFPFLPTIQVEIVPSRASLRAGLHHISIWDVLEGLYYGLRAPISPHEFRTLGPSERDTLHAVAETRRRAMGESDSESGTVRRIDYLGRRRRFVGVRPALAYELPAGGRKLGEVFVVEVGTFSGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPV7</accession>
    <name>A0A2G8RPV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPV7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPV7"/>
    <dbReference type="OrthoDB" id="269151at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="4">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="444" mass="49221" checksum="3663AF19255C8480" modified="2018-01-31" version="1">MLTHIPFPALPVPPSWFPGHMLQFQKMLPALLNKTDVVLELRDSRLPLTSINRNFEGALQKWRRERRQGGAAESTSPSLDTGVSRPTNGPVSQRVVVFSKRDLVPEWGIKVCSGSICGLAVLTEERVQPFQRAMASKFPDQKVFFASWNRARDIRALSELLVNVAREHPYRSELNVLVVGMPNVGKSTLLNALRNIGIAGPTPKALRTSAQPGMTRVLSTRLKLSVDPLVYAYDSPGVMLPFLGKGMVGAERGVKLALIAGIKEGLYDTEALASYLLYRLNVLDPVSPAYLKLLPPDTPPLLDVQEFLALLARRLCMLKRGGIPDSARAAVWFIKWWREEGGLASASAPALPDYSGVPGLETYRRGWGFDLEWNVDAAEASRYDEATIQAKMEDCIDRFEEAGSLEEREGGSISSTQEKKRLKEQQKARQRARSKARLASRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPW2</accession>
    <name>A0A2G8RPW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_14867</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPW2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPW2"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="15580" checksum="C25871AD556B18BD" modified="2018-01-31" version="1">MNAINRYELYVLDEGEKSVEVSEDTKIPNAATIKIVKQDHTLANLLRAQLLGYSSVLFAGYKVPHPLHPYFLLKIQTDGSITPAVILEKACTDLIGMVATLESKFKREFTMNNVEGGVQEDAYGVPTTTGQWESGGAYVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ91</accession>
    <name>A0A2G8RQ91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13433</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ91"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ91"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="304" mass="33439" checksum="FB25EEE40D153C67" modified="2018-01-31" version="1">MSSAPHLKPFNLALIQLGHLGKDKDANLSHASDMIARAVSGDGGLHPKPDLVVLPECFNSLYGHLQFPIYAESIGYTPGQPYDIASSQSQSVKVLSAAAKRHGVWLLGGSIPEREKSSGKLYNTTTVYSPQGELVAIHRKVHLFDIDIPGKIKFKESESLSAGNTLNYFDTEFARIGLGICYDVRFPELAMTAARKGCQVLIYPSAFNTTTGPLHWELLQRARAVDNQVFFSMCSPARDLEQDYHAWGHSMVVDPMGKVLAEANHEETIVFAQIDPKVLEEARAGIPVTTQRRFDVYPDVSNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQD8</accession>
    <name>A0A2G8RQD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQD8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQD8"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="361"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="697"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="726" mass="79107" checksum="B17FF7FD362037BE" modified="2018-01-31" version="1">MVSRATSLHGDDSPPQSVEPPSKRQRARAQKDKGKGKEREREREPAVKVKEEPTVVSLSEHAPVSFPNEDHCSACRSLGALVYCDGCTKAFHWLCLDPPMEASDLPEGESRWFCPACLLEQRPPPKPPTTLKFMGPLVQELGTKIPTEFQLPQDIRSFFKDVGTGPRGTYQDMSQVKQARFNRHGQLEDRDPYRLKDRNGEPVLCFCCGTSALPPGLAADSPTAKRARRSTANVNNYETGRAIISCDYCHLHWHLDCLDPPMIIMPPWSKKWMCPNHAEQTSQPKRRIPRANATPIDIIKPRQWNNGNIEIIQADTAPPPVITPNKVNVDEVLINGRRYRVPERIITLDFWDKIAKNRRGESASEISREVDDSSALSSPLTSLSSLDDQDSVPPFFMEPALYSMDDVNFAQMLCNLRLQSASDSSTIGESRSIPTTNGIQAKRIKVEDDAAKTALDWPQKSAASSSNGGGGTTTRPRRAAATRTAARSRSTRRSGRSGDDDILMDIDFDLPQPALSSGKRPDARRKAARPPEPVDSASHAPSVNGTTPSIATDGDKNASDVTVTESVSTRVSGKPKRTRQPPKTASSRVIAIKPDPDAAQPSLVPPPANARKKNNPSARAPKPDTPLAANGTVHTGPKPEATPTLKIRLPRLGAFNSPSATKESVLETSRVSPTKPAASAVPTRPRRSLRRHASIPTPLNSASVSDAGSSTRINDTGLSTSPIESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQE3</accession>
    <name>A0A2G8RQE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_13472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQE3"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013869945" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL23722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="322" mass="33221" checksum="1FA0D8C52F35C8EF" modified="2018-01-31" version="1">MWKLSVPLLAFVSYVAGLNILLTNDDSWASANIRATYDALKADGHSVLLVAPAVQQSGKGGTFVLPTTNITEAGGEFGTIAAGAPYFGSDAQNGDLFYFNGTPAASVVFGIDVIAPKKFGSAPIDLVVSGPNEGQNNGPFVFTLSGTVGATYVSVERGIPAIAFSAGNNTHRSFTTNTGDASDPANLAAQVVKNLVASVAAGVNTTQERLLPLGVGLSVNIPTFGPESNCTAPPFVFTRLTGGALVAHISINSTTGFPVEDDIEATGINANINGVREDPGETPTSAGCLTAVSIFSVDYDAPERLALFIQHRLRAAVRGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSC9</accession>
    <name>A0A2G8RSC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSC9"/>
    <dbReference type="OrthoDB" id="2748701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="408" mass="45068" checksum="761955D62CCAA347" modified="2018-01-31" version="1">MPWSTLAQPQTTPTAADPTIYVGLCQTMPSATTTGIGSSPLDKLAVELIAHISFYACTDGGPTGCALSLVSKRIRAASRPARFFSVSLTTESSAQLKQFLACYQAECARATDALPRVQHLCISLFGREQGDAPAYPMAHGAVPPVQIQARPAAQPAPTSRAEFLARMQRQTQQWRSAQDRLDEGFSHVVPALIRAVAPDLRSLTFVQARWRVTGSVPQCCFAHLRELTLVGGDMTFLPFALARDGRPQFPSLRRLHHNLAFAGAGLSFLEWAAHAPNLTHLRVSRLDSHPRVIVDTLDQVIGDHAAEEYFPHLQHVTIQPNSAPVPSNSNVDAFVEFREFLEYLERLKERAKAPVVVLPPVEQSIIYPGVDRRLVCLRRLKRQWMERLEGEGPGCWEEGVEGKPLSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSP6</accession>
    <name>A0A2G8RSP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar membrane-associated protein Iml1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSP6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSP6"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="2">
        <location>
            <begin position="139"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="643" mass="71796" checksum="30780EFB622C6637" modified="2018-01-31" version="1">MSRADIPAPPSGRKRSNTAHSVFGNAPMAAPPPPIPALPLQVGDSRVLTVWVNEAGTTGVKLNHKHCAGAVEGDLICIASPLQEHQPGFLFVVPAEDSGLKHQLQISLPKAVLEMFGLKSNSEVTLTKMDKDKYSADFVEFVFQDQYLSRNDMWRLGRDLVGQCLYIDQQVSFIGVIAAKVQALYSNGMKVSSAYISPATKVVYRSLSAKVTIFIQVCRELWEFAGDGERYNEKIVHSFLPALFDKWREMNTNHIVTIVLISRVYYDLSEVEYAAGPLRRDDDGRWYKDFFKVITDLEVLYDWRPTLVALKDSFWAFQRDILLAHHYHRSTVSSPAGHAHEHVRLVGQISYAHDGPVLEALNLALKPTETHYIDRSLSLTGSSTVVITPGTGYFRVSKQLLRLTTTRVLDQGFSIDLVSLAKPPLHQTPIFCFKGAEPETGAGKTGPRTHDPLWGGDAEGSMKETKTFWWEPFWIETSFWDRQMDLPFRKDRFVSRAKMHEIEMLGLLDHDVLSSIEIPYLQAPDRVNVSSQGWTSDMADSDLSKSDSVERKAEPLSPVEADQFDNDVFTIPPDVKPPTARNSLSSTSSGPALSSSFRGHDKRASIMRISDSSRIPRTVLGTVVARGGEGRAGTRRCSKEFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSV5</accession>
    <name>A0A2G8RSV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSV5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSV5"/>
    <dbReference type="OrthoDB" id="10261348at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013169">
        <property type="entry name" value="mRNA_splic_Cwf18-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31551">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08315">
        <property type="entry name" value="cwf18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17999" checksum="B9C60040C32EAD3F" modified="2018-01-31" version="1">MSLADASEARKARLLALRKRRAGEGEDGAGEGDEPVIKHRSFDPETRTLKKRTNDEDVEMEDTVEQRVDGLAEKIIAEDADRRAQDLDLFNIAPKRPNWDLKRELDKKLSKLERKTQESMHTLIRRRLAAQKGESDDIVGAMKAQERAGANDDSSDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSZ0</accession>
    <name>A0A2G8RSZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12519</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSZ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSZ0"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="469" mass="50405" checksum="B9C6CB5BF87649DD" modified="2018-01-31" version="1">MSATTNGDAKYGSRPTAILHRTPWRPPVASSAEGIYVTLEDGKKLIDAVGGAAVSCIGNGHPKVRQAIKDQVDKMSYVYNMQLSNDIAEELAHYLVASSNGAFGAVGFVSGGSEAMEGVIKTARQYFYETGQHQRTNFIARKLSFHGNTVGTLSLAYHPARRAPYLSLLNEQSFHHVSPAYAVRFKGKEESEEQYIERLRKELEDKFLELGPDTVVGFVAETVVGATTGVVAAPKGYFKAMKSVCDKYGALFILDEVMCGMGRMGTLHAWESFGDGVAPDIQAVAKGLGGGYVSIGAVLMSQRIADGVRDNAGFWKHGHTYQAHPIACAGALAVQKVIEEENLLANINEKGAYLGELLRARLAGPNARAAPYVFDIRGAAAWWGVEWEFDVPAAAAKGYAGKTFAMDVQARALENGLIIMGFTGGANIEGTKGNHNMLSPAYNITKEEVEKIVDVFVTSIEEVLAANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTQ6</accession>
    <name>A0A2G8RTQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aip3p/Bud6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12783</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTQ6"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aip3p/Bud6 N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="14797" checksum="4FBB1A3A6CE70CE7" modified="2018-01-31" version="1">MQVPVHASSFVIGQPINPISWPRKLLKPTYISVNTARRPASADSTCTVSSTESSPISPLPSSPSTTSLHSSLSRPESEVQRAVSRLLSLTKQLQELLARWATGAAYEQDVSDAFVLVGSQFDSTVHAFWRVGVDMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU37</accession>
    <name>A0A2G8RU37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_12913</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU37"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF11">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="398"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL25025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="728" mass="80735" checksum="56ED46299939EB1C" modified="2018-01-31" version="1">MPGPRQEQESIDLTPIIDQKDSRPLADRIVPEIVHPPHEDVNRDEIIKQEQDDGGSDSDDTATDSEDEFDWDAEDDAKSAHVAASVKAKRGRLVYRTFLKLPPIFRALLLGAIGAGILITPLLVVRLRFNTSVVKTQVYVWSLWLSITWAAGVATYIVVDAVPHLILVLLRMSNFKIERTRVTIELVAAIRGWLKLALDIAWMWIALSVIRATYKPPGSYWVIINRVLQALFSGGLLVLAEKAFLRYVAINFHRKALADRIAENQLGLRALDRLSNAHPAPKKNMYSGKKGHRSRGSSLDILGMGGEKGGVSGSTSGSSSPTEKEKKQTKKQAKKQRRNLVASVIVDQLGGALEQVTQSQFGSLASAGKLARKLFSTLSDVHPSRKYLIVDDFYPYFPSGADARAAFALFDKDGNGDISKKEMREAVRRIYRERKALTASLKDVGSAVAKLDAVMLSVVGLMFVFICLLIFNRKNTLASLVPLATIIVGFSFIFGHSAQTLFESLIFIFSTHVFDVGDLVMIDEQPLFVREFGLFSTTFRRVDGMEIIAPNSLLASSKLVHNLRRSNSMWESTKVTVAYDTPLEVIEQLRTRLQAYVNTNNREWSGVGVNIDTMEHQNAISLIVAMEHRPNWQDWGGRWVRRTAFMRNLKTVLEDLDIRYTKPIQPIIVPRGPGGFTSPFLDLPPSPRSGGARRGGAGAESRETLGNAGYLDMEPLGRSPSRSLRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVF6</accession>
    <name>A0A2G8RVF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVF6"/>
    <dbReference type="OrthoDB" id="10665230at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="659" mass="70915" checksum="1881F6578ED0C85A" modified="2018-01-31" version="1">MDTSKSTGPKYGEKGARMKNYRQRHQAPMALQRAMGNDRMCMEMCPSPGLHVDKLGDRADPLPPERKRRYEKKKARVQAVNAGDIQSRHNQIKGPRKMAAKKPLAVKNTTPPPEQPPPFLTVFPAAPPPPVPHLPTTQSAASDDRRASSSPFLPEHALAPSTSPWLTVSRYSTDPACADIDAPPMTVKNDQRQNTLDAMCFEFSAAPEPKNTTLSNVWSPTSTPSLESDCGTPSAVQSPPTLGTSWAEGAQTTTPPSSYTVVELDHRASAEQEDASEVLFNEVYQSFFIPRSSWTHPPPTPGLEQEHRDVSSVVPKTRHPSWDAVPRMPDLLFHIPPSQPTTMDPPVLCTRDSPYQGRDSGNRYMPATASSRASRAPRSHGPASRGASSTTGAPAPRVRRHIRATFDPRHAPRPYPSRSDQSAAGHAHLSHYSLAVAEHSVVPRCAVYGGMPPITAIKEPQAQLRQYGGFASLAHAPQDDARHLSTRSLSSHAHTIHTSSIPPTGTASAPLLDEPSIAPPIMQAGIGATTVPTVHASLYPPQVWSGAIASSTTNVAGILACNAHWQNHLPTASHLVPASPGIDTAVLPGTSHAHAAKNDTMARTFGGRFEGELFRLNITVPLLGMDLAIGQSLDGTYLVESSTGSQSDLHQQLLTTSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVH2</accession>
    <name>A0A2G8RVH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000052">
        <property type="protein sequence ID" value="PIL25515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVH2"/>
    <dbReference type="OrthoDB" id="2728951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="672" mass="76207" checksum="04CFD51B92AB905D" modified="2018-01-31" version="1">MSYEQTRKLSGPCIGTKFQDEISTHNELRAETVAAAAEVAMWSLDAAPPQLKERLDEQANLLNVPRVGCERNTAFPFMQMNIVSTQPAGQAGTKIKRELGKVGGKHSDTHDAAGGITTMITDSDIDPETEEWGWFVICDLGVAVELRRLIMVNFCGLREHGGFAPTAKPGFTPKPWSHRFTVPWRLRSDAKELRDEAEERYEQFAWHQRKFVPNGVHLKLGQEARLRAKSLALSGTWGNNTSKRANANANASSSRKRVHKRNPRKRSQGNTLGTRSTTTSGCRNAQMSHVEISPLSTAHRRRYVSLSSLPVVQDPDNEGGEWTDMDVDDVDDEYDSYDLQWGEEGSETRQGMTDKDWDEEMDIDTQEDRMDVDGPPSRRSPEDVSRSSLRKRKRPVVMSPEDSSDDEVHMDDNDYEEDAMVPSAKTNNVTSYQPLLQSFSAVALRSQLAVYSSMADNVEQTLSEKLLSGSQALDEFLNQYESASRFSPELAYALDRVWPSLRDHARALQCFDLRIALERRRYMLANAIAWRWLTEDCVARCKDIISLLVVDAQGLQRSTDWFTRLVRDIFQSYRARCAATLHARDYLPNISNPDQVWDLRGYHRAASCPIAMLTCDEVLDLLACWLHFPTNTRRISATFVTRLVEVTGNVDILLLNTVWHAHQTVQIYRTRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVM9</accession>
    <name>A0A2G8RVM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000046">
        <property type="protein sequence ID" value="PIL25563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVM9"/>
    <dbReference type="OrthoDB" id="2692698at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="661" mass="69609" checksum="7D3D6B99D575023F" modified="2018-01-31" version="1">MASIFANNRILPNLKRRARPTNKSDNSPSKSKPLHILPNVAEEDESPSRESCSSLSSLPTIPSPSYRHSPYVAASATLGARPTHDKRDSRRVVLTGVEGITFDDFFPLSSAPRARTPSPPRRPITPPPRSVTSSPAAESPLDDINLRFSGLGISLDFPSPPATTTRIPSLSRKREQSPSPSVTSSEASTCSPKTPCSTPPTSDDDESPRKASNLMRAPTFKSQRASVLFVQPMHELAEPVRKASITSLLDDDVSEEVAWIAQDISEFVTLASPLPPAFPVEASSQSESRARPDSVLPPPRKPSRANKPSLPRISIQDSSARGPSAQLDPTFPLKRRSYLVPSRPPPPPPVSVPVPTSPKSPVSAMERATEELLAELANAALGAGFRGTGLAVPHAQVDALSISGSVPPSPSSQFIVTTPVTPPPSSALRPPPRSSVPADILLDYCDCDSPVDTPASGSGQRWPTTPMSAATTTATASVYSQTTDSAPVSPLSSFDFDVSGVRPATPSSPAVPRRMPSTRSVGSGSDPERALRSRWSTSTLGSVADAHAHGWRGIFTLSPSKRGKGPSKHSHAHSNGHGNGNGNGYAAHLQRKNAVKSSHAPKRSMDSGVSRRDSRSSRVSESSASDSGESAASSGSGSGLRRKPIPLTLLSVGGPANSMQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWY4</accession>
    <name>A0A2G8RWY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWY4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="14865" checksum="DE23F6734E426938" modified="2018-01-31" version="1">MKLAMRMKRPAGPAIPQLTPPFEAPFLEEVGAWEPPVPLGVEAAPLEGTAPTPLSGICTGTKVAIEVYVAWATLVVVVPSMTPTTIPDAEQEAATAPPLAGVARAHPSEARMLRVAPPTTVFVDPISCTSVDPATRVTVWYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWZ3</accession>
    <name>A0A2G8RWZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glyceraldehyde 3-phosphate dehydrogenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWZ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWZ3"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL26039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="138" mass="14756" checksum="98CC5408D67A0872" modified="2018-01-31" version="1">MKDWCGGRGVGPNIIPSSTVGKVIPSLTGKLTSASSIRVPTLDVIARLARPKTYDEIKHAVRDATAEGSLKGLIAYTEDKVVSSDFVGKDASAVFDAEAGIALNPQFVKLVVWYESEWGYSHRVCDLVACAAKMNDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX93</accession>
    <name>A0A2G8RX93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX93"/>
    <dbReference type="OrthoDB" id="3256413at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="559" mass="61800" checksum="4E8B0AB555DFF635" modified="2018-01-31" version="1">MRLTFLPSEILAEILIDLDRRDLLRCREVTVGFDTSQSFNNLIHLYFGIQICTKFKALIDEDVRAQYKVHLSVAGLQNGPPSTISTGGRLSTLRVYQHAWNEFVWSAKEDVSMSTDIADSWELYGNVLAQVEGMRTLHFKQIPSAIRGIKGTAWTIPDVGCNITEIGLDPAQDLLVIIEDFEDNTELTCRVHLHLRSLATGAPRPAAPATAMLTHEPEPGGYSYAIQVSEDNLGILLSSMDFGDPSELLIWNWKTGQLHLHIVGIGLHSWAFLTSRLLILAHSSEEDPRLLVVDLDSPQPSTPTMLSELDFLCAFCYPPFRDEVSVLDMLVRSNPAPTWRPSPALAVPFSVSPADRLFVVTFWLIEYDEEAVMLSLVPASTLLRAIATLAPGEMETARKRVFAWAEWGPRGSRLVEAPSSYTSTEVCYVYGTRFAHVEKDWDEGAGRLRKFVVVRDFNQLAVRRAGAAGTSGGKGSALGSSGVRMGDKEQSVRVVDAKTLGPPGVFQEEEVTTALPYVERICVLASEDGEFNAVMLTEDAMVLVAGTWQSPLRYRILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXC6</accession>
    <name>A0A2G8RXC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXC6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXC6"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="490"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="712"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL26173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="859" mass="95212" checksum="116DC8D1940C3CC2" modified="2018-01-31" version="1">MESSPSPSLIPLPPLVLLEELLYPRLPVEVIERIIDMSSADTKTLSDISQSCRTLLTRSRLRLFVRIHIRTMQQMRAVGDFLDHRPWLHSLIQRVAIGPSNGVDSSPIPDREQLALAMVVPLPLFKLPNLTHWEILFDRPSGGPTLSLNRSASSGFGYYGIHIRTLTLKHVHFPSLADFGRLLLAFSNIRDLEYSECKIAREESSTGDDVIQQRLAERLCLTCLSASVDELGRALLKTSHATLQHLTLSCPYKTQGRIIEEISQYPCLKSLSLEITVNELEFIDSGFTRRTFPFLENIQHLETKGVRKLDVTVGLKYPSLLHGFYNFLFYRVTPDLCHRLEATLLRSSFHPTLVLQTLGQNTTYATTSYRTQLWQASIQTLFPALNQQSRLRIENPEVFRDSLQRHEGPISTLVTSPNGPWFASGSYDSTIIIWDSRTGAIIYDWPAHVLSVDSLAFSPDGRYLCSTGGDTTPKIWDLYSPSGAALATTLVGHTAIVRHCAWSSSGTLLATGSNDGSVRLWDGPCARGGVCQEVPLANGQCSGTRVSAVEFCPRDGSWLFAIYKSSTTDAGRRDFRLWHFTAAGSPSRSASVQKDFGWSPPVVAAAFGGSSSSSSSSSSCSSQQLATVSLNAEAVCVWDLETEMQLFAIPFSYHHANVNVDLKYSLDGRSVVAPVPEQGFQPNKVDLWDTESGKLKLTFDGELFGLPSFSPDGSAAQVALAHEHVRAPDKEGEGDEGRITFVHADMTKLEYAEGSFDAVLAFYSIFHLRQEEQAPMVGRMVAWLQPGRYLLLNMGTEEGDFLSEDWMGARMFSSGIGVEGNRRAFEKHGKGLKILADEVATEMVGRFEEKSHWVFAVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXE1</accession>
    <name>A0A2G8RXE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXE1"/>
    <dbReference type="OrthoDB" id="3027208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="52"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="352" mass="39348" checksum="FC1AB2C0237B0EEA" modified="2018-01-31" version="1">MTDDPRSPKRPRLSVSPRAILIVSPGDSSGSESDAAGEEKYTRDLDFWLDDGNLILLAGRSAFRVYRGLLVKNSPVFADMFTTGSAGATETFDNCPVVRLADHPQNLRDFLQYLMPCSALVLVEEVPECRFEQLHAAFHLAHKYQCQDVEARILFVLKKFYTSNFNDHDRYATSKYTLVPPPPQAAIAAVNIARLTSTLSMLPFALYLVCTLEGRAVDGYERRDGSAEHLSAEDLKLCMNARGTLAWELAALTKTVFSSTEYPSLQCMHPDSCVVAEDTMFCETQESVPGGCDVLESYRESVDEWAKAYGMCKGCKRKLLARDREERRKMWIKLPGVFGFTVQACGFTNVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXT0</accession>
    <name>A0A2G8RXT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_12079</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RXT0"/>
    <dbReference type="OrthoDB" id="1750432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="350"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="1098"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="843"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1667"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1725"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="855"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1667"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1732"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1757"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1782"/>
            <end position="1793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL26323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1793" mass="199874" checksum="5736EB618C685675" modified="2018-01-31" version="1">MALVLEERLNEAIAYPSGFSGDRSTARFHCFQLGDMVEILDHYLAMSINVSCELLQNPRLDFRDWYAHAALRHQAEFASPEFELDDLEGELTVLFASEPAPNPEPADLTVELNAAQPGKRGKKDEPDNLTVQRNAAIPRDLRRVIPEPIVVVVLINGQPACALLDTGSLADFMSAKLAHQLKVDAFELAKPMPLHLAVQGSRAKINYGCTAQIEYQSICAKRYFDIINLLNYDVILGTPFFYQHRVLTGFNPTKVVIGSTMPLAIEGKQARVLESRAAEMFEDRLEAARAKLREYAAPICKEASDSPLPPLRAINHAIPLKDESKIYSWRPSRCPDALRHLWSEKREAYLKSGRWKMTNARNTSPMLLLTKPGTGVKGIPPCLRVVCDLCERNTNTHKVTSPLLDMEGILRCISRKPYRSLIDGKDAYEQIRIEPAHVPHTAMTTPDGNMVSLVLQQGDCNAVATYQTLMNHIFAPYIGVFLDVYLDDIAVYSDTLELHIKHISLVVDILRKEQLYLSASKLKFLCAEMKVLGRIVDDKGIRMDPDKVDNVLNWKVPTNRELLRGFLGSVGYLADDIATVRIPMGVLSSLTGTEISFRWEYTYQRAFDEIKKLLHAHREHHRVPLDYSEDAPRIWLVTDGSHGGVAGVVTQGDDFRKGKVAAFFSAKLSSAQMNYPVHEIEMLAGVESMRRHRDILLGCTFTWVTDHKGLTHLLKQRNLSGRQARWLEHISEFNFEVEYVPGIENVLADALSRIYAHDRPGTVRAPSEYTFFDEEGDFASTLSSFSISTPVIVDPEAIIAIDEDAPPTRVLQPRPPRVPPLAERPTRQTRVLTAVPAPVNIAATASDAPPTPVGGERKLPEPDRDGAGVVPTTLTGSITPRTAEGRRTRRARVDVPPAETGRPETAQEFSKCIQRVTLRLPNGGRQEGACPMDSANGQQPTDQVTLPDEYQPVAPPLEQENQFLSYLSQNTEGLDLLGVLKGRYTEDKFFASISENAKHFKNFLVKDGLVFVRDNHKLLLCVPDIQVNDRSAREIVIRHAHSLLAHLGTHRTLTLLRDHLWWKSMAADVQKYCETCMTCKRSKPDNQKPYGLLNPLSVPSRPWQTIAVDFVGPLPESTNRDGTFDEITTIIDLHSGMVHLVPSRQDYKAPEVAELMFAEVYRLHGMPESIVSDRDVLFTSLFWTHLNKLIGVELRMSSAYHPQSDGSAERANRTVGQMLKQCIGPNQKDWVRKLPAIEFAINLARNESTGFAPFFLNTGRMPRAMVWDSATQDEYPGVRVFAQRVKNAVMAAHDSILAARVKQTRNANRHRRPAPFAAGDLVYISTLNISLPKGYARKLAPKYIGPYRIVRDFGNSSYQIDLPSNLRRRGIHNVFHASLLRVHIPNDDRLFPGRLDSQVAELEDRDNEWAIEKIVSHRGRGGDAVFEALWKSGDRTWVPYSTVRHLGALTAYLEAMGADGVSDLDEGSGTPPSDPQVFLGFLRVPTRRHEPIKRKTLVPQSSPSSTILDSTSLPLTLELFSIAFSMPLQHSRLDPNRPGFTLLDENGVPHSWVLAQFREFVRFDRDLRSGAVSAANLIIPGDYGFFTALFNSDTDCLYQFSSFDPATNSTTVRGAPIPAQLLDELDPPPTVTFAEPAPAEPQFTPQRIRTIERMLWGSAEREARYLERRDSMQDRRTEDRKRKRIEHCAADEARASKPPPFTTATSSTGILAVAAGSSGGATILSTAAPRGSGSSCPAAGTSSGSSTHQATRREASPMEEDKDAEGEDDTELLEYTEEALSGKKKAGKGKKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYJ7</accession>
    <name>A0A2G8RYJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYJ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYJ7"/>
    <dbReference type="OrthoDB" id="3067110at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="110" mass="11755" checksum="23C462D53CA1438A" modified="2018-01-31" version="1">MTMPTLPNITLSESLIGRAEPVFEPPISKTQFTLDSSGVAGFFGGESAVRATATVNLVPQRRWCGWYNASGSYDVAKQYGLLAMSDTVDGLFPGGQRDPAKILMVDGQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYR1</accession>
    <name>A0A2G8RYR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase S1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYR1"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9680" checksum="C41B3EA21A81F630" modified="2018-01-31" version="1">MKDGNVNTCDASGTVESVELPVYNYDKRFGPFSAGGDSGALAFDGRGRMVGILHSVLASGGSNRVTYATPARWAVEQLRLQYPHADFEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYY0</accession>
    <name>A0A2G8RYY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYY0"/>
    <dbReference type="OrthoDB" id="3027208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="50"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="347" mass="38553" checksum="6BE280F19D616DC3" modified="2018-01-31" version="1">MQTLDARSPKRRRTSSTPKPLFIVAPGESPELPNGQEKFTRHADFWLDDGNLILLAGDTAFRVYKGLLTKNSGVFADMFATGSADATETFDSCPVVRLPDHPADLSDFLQYLMPCSKLRLCDGLPVSDFAELHAAIHLAHKYQCPDVEMRALSLLKNFYSPPLADHHVHAHSPKSPMARPPRLAAIAAANVARLTETPSMIPFALYQVSTLEGAMLDGYARRDGSIEHLSASDLRLCIDARGSLAHEMVLYVRSAFTPGHSDRCTNIEQCTMALNDIRDDMEERLGTCDILDAYKGRPIEVWLADFELCEACAGEVLVREDAERRRVWRLLPGIFGMTAKECGFPQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ45</accession>
    <name>A0A2G8RZ45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ45"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="12988" checksum="EA253B39E07A7BBB" modified="2018-01-31" version="1">MSLGNSVAALALRPVDINDLPERTRILAHEDPPPEHPSVVGSTALYITSLASRVASIDRLASPAQAGLFSDAYTKADINTFETDVLKQLWMMTIALGINVHPVSRSSPPTARCPPRTEQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ50</accession>
    <name>A0A2G8RZ50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ50"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ50"/>
    <dbReference type="OrthoDB" id="3360715at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="57504" checksum="E1B6BFD066F3938F" modified="2018-01-31" version="1">MSNIRQAVDSTEPTLAEDFVQECFHSYLKSSLTHAKVEGLLDESALASAEADLMITGPALCLYFAALRSTTSPPSVPLPRRAKSGSNLPPTDLSLKNCPPAFRQFLIVWSQLVPSIQALTPEHQHDLARVICGLEPQATPLNPRLNGIAADLRAVAIEISMRRTFQEKYAGDLQVALDTGTVRSPGGRALKASFVPPPSYDAPPSPALAPAPAPAPAGLTPSSTPPVSPSRLPLPSSPAASASTLTVPTSPSRSARRTHSPSASISSATSSRSHSPSTQSEVFSPTILAEDIPGIEFIRETLYAALADVLERRAALRQLLRTDPARAYFAAVALAILDVASSSATRPDPQREGLPPSPGSGEGPVIRGVLGQTLALSECPAALRPFMAELCAVGTALHAMEEEDSEATVRALQRGDEALPVPRHERVREILERGVGHARRESDVGRAGDGEDGEALRRRRTSTEGRAVAFANRINALALGMTGLRAFRERQETVFRSTDANRALSVLREREPVTTFLQAVAMEAAWLFYMRLPSQSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZK9</accession>
    <name>A0A2G8RZK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZK9"/>
    <dbReference type="OrthoDB" id="2754513at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="36123" checksum="BA7837CE86A05B0D" modified="2018-01-31" version="1">MLAYPCPVCYDYGCLQEHRWYSVENTVLIQTVLKGLQEILRRDNNARANYPGGAGMIDSPPHYIYSPAYPPTIYPPTFNAADSFGTKAMDALADRIQDISISPPAYSADIWAAQGSAPVSPQEGFGPSPNYDVLAPWSEGYVSVPQDAGPSGDVDNISYAEQHVNRVEPSFIPTVPTAPGPVPSISVIEHLDQGTYAPKQCVKGTPAGPVYFNGGRGVSLGSLAALANGGDPAFDAAASIGDKASVRFELPQFSGHSIQVRVRHGDKKGREGRPITVREMGDTVFDVLRKLMSHGEARGEPLRHGGSVVDIERVVLLRVDQISKGSIQPILGIRNNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZN9</accession>
    <name>A0A2G8RZN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZN9"/>
    <dbReference type="OrthoDB" id="2756141at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="216" mass="24436" checksum="E55108E472D8D8A8" modified="2018-01-31" version="1">MAYYPTTALCNYMDEYLFGCAYRDLTLNGSAVSPFALTYEEQVRVLRIAARGGFRNSNWPADVAVPPRPFALLMCWGVWDNPLAVDLVNSVCLRSTYQCTGQPRFFGDPGSLVDFFEPDMVDHGVMSHWNYPPYGRTAIWRMPGPDCDYGCASGDYLLRDDLSDVCIVGQPLHYGPFTSAVVRRVLVGESQRRRVWNSMPDNIPLESRNVLWRSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZY9</accession>
    <name>A0A2G8RZY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_10229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZY9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZY9"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="259" mass="27662" checksum="65613B7B3D2C98F8" modified="2018-01-31" version="1">MLPQAAHTLYTNGGWAQFYHGLVPTLVQGLLSRFGDTAANVGVLALLRCNSYLKGLPALAKAVFASLAGTEFRMVLTPVDTVKMTMQTDGNAGMEILRSKIKSYGLGSLCYGAIGAAAAGLAGHYPSYGTNSYLDEVLPAPRASERNSSNVHETPIGYVAAVEAVVAEDGLRGLLGRGLKTLILANGVQGLMFSVLWKMFLNMWEGKASARIRSSDSITYTGRIITTLAVFMPFFASLEFLVSVIILAGLVLRTSKHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S004</accession>
    <name>A0A2G8S004_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S004"/>
    <dbReference type="OrthoDB" id="2726860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="236"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="336" mass="38609" checksum="605F68EDDE81B09B" modified="2018-01-31" version="1">MWLLNTARAELEFFPTPESVPRGYAILSHVWDKTEQTFQDIQALRIKCAEDGTNPRDLVCDKVRAFCVLAERAGHEWGWADMCCIDKTSSTELSEAIVSMYRYYSLAEVCYAYLRDVPTTSEDDLRGPDSESAFRASRWHKRGWTLQELIAPSLVLFLSCTWEILGSKADLADLLEEITRVPAAVLRLEDEHSAHCVAARMSWAADRETTRPEDEVYCLMGIFGIFMPPLYGEGKNAFLRLQEEIMKQVDDPSIFAWGDVYSIPMADLDDDQVLNVWSRNFPKRMATVYGSFANSPSDFRLGHRMKHSAERRPPRQTFWERFKRVSRHSPNSPVDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S062</accession>
    <name>A0A2G8S062_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S062"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="90" mass="10162" checksum="6623F4DB97E744D5" modified="2018-01-31" version="1">MALTHLFADMITGSDDSSLRNVFETTLSVLNVGKTNRPRSSLSKASRLGLQQSVWEQSSQRNKTFSERLRARAGILIQRRIEKKGVLQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S069</accession>
    <name>A0A2G8S069_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10286</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S069"/>
    <dbReference type="STRING" id="1077348.A0A2G8S069"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013431297" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="493" mass="54644" checksum="24B147C183CDC1BB" modified="2018-01-31" version="1">MKLLLSGLLAYAGSFATSAAQQSGFGGQNAFSAYDDGLFTPVGDLSALSSTEFTTLSHPAFARHKVRVKQSKFCDGSVRAYTGYIDIEARHLFFYFFESRRDPDTDDVIFWTSGGPGASSSLGLFMELGPCRVTSANETKRNPYGWNDQANIFFVDQPVGVGFSYAEYGESVATTKDAGDDIAAFMSIFFEHFTKFKGRALHLAGESYGGRYIPVFASAIYDNNPRLIEAGLTPINISSIMIGNGCTDSGTMYPSYYRTRCEDPTFPPTDGISDCVRMKQLVPRCEKRYQESCVDKFDMIDCGAALEFCESAVGTTYRDLNNYDRARPCKGLSITECYPIIQHITNFLNKDHIQSLLGVDPVARGRGFQWNSMDINMAFWETLDISSFPAHYYIAALLERGIRALIYVGATDFICNWMGNEAMTMGLEWSKKDEFRREPLHVWTIKGNQIAGLTRSGGGLTFATIVGAGHMAPYDKPIESLELANKWLAGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0D9</accession>
    <name>A0A2G8S0D9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0D9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0D9"/>
    <dbReference type="OrthoDB" id="2766512at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="137"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="208" mass="23826" checksum="45A0C3384DF1BB08" modified="2018-01-31" version="1">MQSSKAPGRRSKINRGPPADNTWWVFQVKCNADGSIECYKGHLIAKGFSQRPGFEYNETFAPTPKWTSIQAILALAALKDLELELVDISSAYLNGKLKEEVYMYQPDGFEEKTPQWVWRLRKALYGLNVWVYLCNGMQLIIPVFVDNITIAGKDKAVIQKVKDNLHKHFKLWDLGPTSWLLGVEIERDCSKHSLSISQCQYAFDILER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1T5</accession>
    <name>A0A2G8S1T5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="9">HMG-CoA reductase</shortName>
            <ecNumber evidence="9">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_10864</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="9"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1T5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1T5"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="224"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="722"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1182"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1201"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL27711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1226" mass="131279" checksum="E3643B1123A972A0" modified="2018-01-31" version="1">MRAILRPLSTHTVFSPIETIVSVFVLATLAYFHILTGIKHSSFFASSHPPALRPAFARLTNQEWVAVSQHDWSEAWKHPGSNLDPLELQQVVFTLDDKTQPTALLDASAISQHLVSNVPALSGKAYSSICHHPNVSGTSCFTSVSGPGSSPILTLSFMPGTRDDWLGSFRKEKTITLDGVEYSIDAGKRQESIGDMESSKWVAYAVSALVLRFWELTKKADSLDILVVLTGYVLMHVTFMRLFLSSRALGSNFWLSAGIFSSATISFLFTLPMCRSMDIPLDPIALTEALPFLVCTVGFDKPLRLARAVMAHPHMLKPQDDGRMKTAGDVILEALDRVGNVILRDYALEIAVLFVGVNSRVGGLKEFCAVAAALLAMDCLMTFTLYTAVLTIMVEVRRIKKVRDMTRARSRSSSITAVTANGTAVRGVLSRKSSTQSVAETETAKNLRQRATDSAIGVKGSFLKDGSRLQEAEENPMARLKLLLIASFLTLHILNFCTTLTPATANARHQRHPLRTAPEAVPTPRVDITSPAIASVLSHLALTQEPVFTVESSEPIDLIVKVAAPIYVHALPLAPALRASNANTGEAIENFMSSWSSLVGDPVVSKWIVALLAVSVVLNGYLLKGIAAGSGLAAMRAVRSQGVRFRSRARSIVKIADEPEAEQEHAPAPSVMFMASAAPVVEAPAPAPVPEPEHAPVTRPPLTIFSRPLNLETVDKKLQDALPIRSPPPVEPITPESREAEPTQVEVRSLAECVDVFENGPRPVSVALKTLNDEEVILLSQTGKIAPYALEKMLGDFDRAVRIRRALISRASRTKTLENSLIPMKDYDYARVMGACCENVIGFMPLPLGIAGPLKVDGLMYPIPMATAEGTLVASTSRGCKALNAGGGVTTVLTADGMTRGPAIDFPSIVRAAEAKAWIESDDGYATIKAAFESTSRFAKLQRIKSALAGRTLFVRFATRTGDAMGMNMISKATEKALEVLSHEFPEMVVLALSGNYCTDKKPAAINWIEGRGKSIVAEAVIPGKVVKSVLKTTVEGLCNVNTKKNLIGSAMAGAVGGFNAHAANILTAVFLATGQDPAQNVESSNCMTLMEPTNGGEDLLMTVSMPCIEVGTVGGGTILEPQGAVLDLLGVRGAHPTNPGQNAQQLARIIASAVMAGELSLISALAAGHLVRAHLAHNRSQLNTPMPSRPHTPGPEEVSHVQQLPTPSANDDKGVAAQGYVVEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2P7</accession>
    <name>A0A2G8S2P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2P7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2P7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="535" mass="58590" checksum="97EF3CF7E1AFC046" modified="2018-01-31" version="1">MYTVNGLPWHSQSVAFVPKYDTDVPWSLQNNANAWYCNKGHCLTSEPIDTDDSLRKRLRSALGGSAATATGGLEIQLYLVAPATPAPRFRFSMGVHVEEERQTYVSSNQRAHWAARGVWYGFNGYHDGDNSILTRMAALFEPAFAYAQNALWGLQDTTPLGEGENCEEEGNAGSVGAVVDATGLSGKDDVLDAHLFMAQLRDTFNGLKMGFSESESKQGAFTHGVALSKVLQLLFDDPTLDAWVQVSMNHLPRIEIEAECPTPCGIPALYVFANDRLTSLRDPKMESQGVLEGMAAYRDAILKTTRAPIYDATCCPCLVIGTAGATLQIFAAYFADRIYRTHLCDFALDADADAHHDVAAVATKLRVIRNTARMLREGYARVHVGAYILPPTHTCRPHLLPRPTILMPVPAPLPVHLYLRDRVTRGQNSDVFTGTLTLSAHRGTDDSESSDRELPVHVKFVPEYSVAAHRLLATHTDASGAPRPLAPQLYWAGEIVPGLWMIVMETLPPDARMLYRVLAAGTPTRTARSSLRGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2R6</accession>
    <name>A0A2G8S2R6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_10992</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2R6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2R6"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000608">
        <property type="entry name" value="Mov10 RISC complex RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="15">
        <location>
            <begin position="337"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="13">
        <location>
            <begin position="475"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="13">
        <location>
            <begin position="588"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="14">
        <location>
            <begin position="668"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="940"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL27838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="966" mass="107168" checksum="D542371BBF84DFFC" modified="2018-01-31" version="1">MSLISSNYCPNVLYGGGCNDSSCLGNHDVCLCELCVLICSPASNFASHIRSWKHLENASKAAPPSRVISGELIRCPPCSVTVSSTQWGTHITGDSHRRHQELASLRAAYELAESDKQGVRVSHFDAGVDFGAIDVDQAAAGRRFEVTLSSDKHVTLVRTWVRARISNHAGLFKALCRANTALTPGSEVSIPILFRHGGRGRYEARLEFTFQGLSGREFVIARRLLALVGEAADREVLKSVTPYIRSRRVRWDENTDVLAGDLPPRMIRPIKWARDLLPFNIPSALAEVLQSGTHPEILLRLSQEYLTDPLSLENYQSFFPVLLWIEESRMVDDLRMYDMRDVQFEPDGRLYSLHIYGLAEGRPSVTIGISKQSPGDVILVQEGGGGRTFKGIVHDIRQEDVRISFHPDFPGASRTYNVRFQLNRTPLRRMHQAIVATIKSPRRLLFPEAGDEGLESPVAGTDSRLQLFNTSIGGNAPQLAAVESILQLRPGCAPFVLFGPPGTGKTVTLVETILQLLHEQPDARILACAPSNSAADIIAERLVKQGLSPEELFRCNAATRNPASVPQELLQYIYRPGNMYALPTMDKLQHFRVIVSTCTNSSFAYNIGMPLGHFTHIFVDEAGQASEPEMLVAIKPLLAQNTRVILSGDPKQLGPVIRSSMAREFGLEKSFLERLMDRPLYSSEDGRGRSFVKLVKNYRSHEAILRYPNEKFYDGELEVCGSVGTINTFLRSPQLVSPEFPVVFHAISGQNEREASSPSWFNKEEVLQVKAYIVALLQDRQFPLLPEDIGVITPYHAQVRKIRHLLQLAKLSDVKVGSVEEFQGQERKVILVSTVRSSGDMLAYDAKFALGFLSNARRFNVAMTRAKALLIVVGDAPILSVDPLWRAFMNYIHTNNGWRGDAPTWDVNAAVLEGADYVDELREAIAADMNAVMAQLPPEEDMEAEANVEREAVSGSWESGGGDNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3A6</accession>
    <name>A0A2G8S3A6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3A6"/>
    <dbReference type="OrthoDB" id="2745919at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="48209" checksum="441815CB4EB8EB1E" modified="2018-01-31" version="1">MSMKDVKRALPDLFKLASHSLESLTILDLDVFSFRPPELKAMLDSLPRLRELEMSGVQKKYQNALTDTLPHLCTLILAFYDDDTDTRPFLWTPHGAPNLQTLTLYNGTLPAKEDTSLTFPAVHTLRVCPRLFPDDVDACTRIFPNVRHATLDFPEGYGALSPAFRMDMRTYRPGMAWPDPSVQAWRASFLVRVQTAEHRGPDAWPHLQSVRAAGRDAWNLGWAGLARGVARLEMACGQWSWREQAPGAPGGQRTLAGVLGELRPGCVVFHPSAFDSPYTRRVFRWPQLLALQDAPGVRRLAMVFCEMVGRGYVCRAVWPRQLREVLEKTAVSSLLIRLDYAYPASQERSDLFERWRAGLLGVTSALRVVLFQVQSEAVLGWAKEERAGGIIWKEMDEYTKRKFLASENISPASVEPCDWCERRARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3E9</accession>
    <name>A0A2G8S3E9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_09589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3E9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3E9"/>
    <dbReference type="OrthoDB" id="3196168at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL28300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="654" mass="70920" checksum="833708CBEFA85407" modified="2018-01-31" version="1">MTIGRAIGIDLGTTNCRVAVWHKERVEIIPNDQGNPSTPSYVAFTDTDCLIGDVAKTQAALNPRNTVFNVKRLIGRSFSDPEVQADIKHFPFSVFDRDSKPCIRVRHRGQMREFAPEDILSMILSYLKKTAEAFLHDSVTSAVISVPVYFNYAQRQAVETAARAAGLQVLRLVAEPSCSTLAYYMKKPASKYEVRVLVLDVGAGGTNVQLMEMHDHFVHTLSTAGSLHLGGEDFDSRLVSHLAQQFRREHGRDITNNVRALRRLHTACESAKCTLSDAAKTAIAIDALCDSVDFYTTVTSARFARLCQDLFRSLCELIETVLPDAKIHKSQVDEIVLVGGSTSMQPIKKLVSDFFDGKRTTVVHGVPWGATVAYGAAVQAAVITGDASKRLLDVMLSDVTPHSLGIETVGGFMTPLLRRNDKIPIKRTRTVTTTSDNQPGVLIEVYEGGRTRAKHNTLLARLVLAGIPPAPRGVPCIDVTINVNEDHRVVVSATDTTTGRSTSVVIPGEKQGLTDAEVIDMVVDANIAAARSAARARFAGFADDLRAALQGLQPALQAADAWLAETQSADAPIPVSILEYDAHLEEIKAFARPLVERLAFAIGSDGLDGVGIPEVDVVDEDILRKWTVVVAGPDDGPSTAPDVVHEDDAMDTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3I6</accession>
    <name>A0A2G8S3I6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3I6"/>
    <dbReference type="OrthoDB" id="2747524at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="56751" checksum="C86632CB1D412BD2" modified="2018-01-31" version="1">MFRRIHCTVGVGPAPTPEFYFPPSLWSYIQHLTLMDDCFHLTHGRDQLDVPNMRLRPPSHIPHLYVCEEFLGPVVQRTLRQMPLLTKLSLRTCLGVVHGPYWTFLRFALSLPHLREFEMVGLTFCPVVLPDEPFDLDIEGGTCAPLTVFRYEAILTRGRKYAISVEKDALALVLEKTHHSLVTLALPSEPAPISLMARLDWPNLRELRLRGMRWSAPRTPLVILFANMPKLRSLALELRIPDDGDPEAVWPPGLPRSTKFPWPELEHLTVANPHPDDELFAHLPPGLRTLALPSCPRECVKDWLWACENPYCLLAHTFHLLQASRLLGVLKRCSASGLRHLEIEYGTDEREHDLLRFLAAAFPRLSSLSIYRYRGSRETVVCVEDVVRPLASLEGLQALTLHPDFETRPTRIVNIMRGGRLIYPTDALERFANILEGAALRIARTLDKSLERVSLWTPSDGEGPFSANFSVFRDDCTNDVRIQREADTPHEREDVWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4K5</accession>
    <name>A0A2G8S4K5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4K5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4K5"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013916721" description="Transporter" evidence="3">
        <location>
            <begin position="21"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="51611" checksum="E1000CCBD62C4EFE" modified="2018-01-31" version="1">MRTRCIGAFVAAAFLVAARATQTIMVDDGDPGIEYRGAWVHNPIDDPKDFNYGGSVTFTNATGSTATYRFAGTAIAVFGAFEVPGTFAMHSSYSIDGGQAVEFLPASTIARASYRQKFFQSDTLSDGEHTLIITNGGKEFWLDYLLVTQESPSTTIAPTTSATQKPQALPSSTAQASPHTVVPATPSPGPISAGRSETLQSSSSGPSSQTQTTQSFTSTNNATLTSTDAAALSPFSTSSTPQSQTSTFALGIPSTIPSSAPEHAHSAKMAVGAIAGLAVAGLLVVVLIGLVGWRSRRRRKPTKHGDLAPYDPGLTALAFEPSEKHEHERAREEGTGSRGSAASSLLSLSLPRAAQVHTQAPDLEEARAFWSSADRGVPHEIQTTDLSGPGMIAGDNRLTGFEPLGSPSSASSLLGRHPRRTLRHKGSPIAPSWGKSGSVSSALDERRRSVDGGVRIAGGPPPVGNLRREDDNADDVRSGLSTLPPSYQLYPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4X2</accession>
    <name>A0A2G8S4X2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4X2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4X2"/>
    <dbReference type="OrthoDB" id="2764578at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="1">
        <location>
            <begin position="2"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="199" mass="22502" checksum="EA3904558A300445" modified="2018-01-31" version="1">MERPRHLLGRVCYIPPSESGVDFVYSGYIDFDSTKSGAPAPDLFPLSPEIIEHESPHIELKTVYISHPKPDRTNSYPPWSIRGQPYTAIKLVLLRDTRNALRSRGYSINLRDPIPDHPTAHRLMLSKDEHTITVEFQHVLSDGGKRFTINATVKLSGSRSGVQFDSAQPGPCSRLYHRAVSWTDGNWEGWDIVLKAQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5A4</accession>
    <name>A0A2G8S5A4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5A4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5A4"/>
    <dbReference type="OrthoDB" id="3208561at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="26708" checksum="6425C4E26AF287EE" modified="2018-01-31" version="1">MPMLSRLALCDYPREYHEDLVTRRGRPSIVEGNRMNKPWFSSIPTNIGLLSILGRMELPLLTSLEIAYVVVPSWDKSEHALLAHVVDAFPRLQHLEIRRYRTNWRELTRYTPIAKILSRARSLRTVRLGLDCYNDPGAYCCWSSRRDRWLEKLRTKVGPEIIKIMQARCPALEHVAILYHGSPSSIWIEFHPSRSPVGGGEPRPPGFVMSYDEQYIDSEMITRMGGRDVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6B2</accession>
    <name>A0A2G8S6B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6B2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6B2"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="536" mass="58379" checksum="DA80BFA104801E40" modified="2018-01-31" version="1">MGQGSTDYSKHSVPQGQVDVKERPARDDYSERLVGDTNYDLSVGGLSLEEDAAGGGGRHMGVFTCTLLVIGRMIGTAIFSTPSSILGSVGSVGASLMLWLLGFFISICGLFIWLELGTMFPRSGGEKVYLEAVYTKPKYLVTVLFAFNAIILGFNASSCIVFAQNILITAGRDADRWVTRGIALAVALFVVLIHGLTPKLGIWLMNALNVFKVIILLFISFTGWAVLARKTAVQDPHANFHNVFAGSSSSSNDYATAMFKVLHAYDGWSNVNYVLNNVKNPIRTLKIAGPLGLSISTMLYFLANIAFFAAATKQEIIESGVTVASLFFHNVFGEKAQKALTVSVALSALGAFAAARVNQELAKEGIPLPFGNKLWASNWPTGKSPLLGLIIHTIPSVIVIIGPPPAVAYPFIIDVEGYPQQIVNFFVVIGLFWLRYRRPNAPRPFKVWLPMGAFFLAAAAFLIIAPFLRPENGIGDTPPLPYYLYCLVGIAVITSGIIYWGLWRVAPRWFGYKFVPRKEKLSDGTVVAVFSTKKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6F4</accession>
    <name>A0A2G8S6F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_09407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S6F4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1149"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="463"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="676"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1034"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1335"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="381"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="957"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="967"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL29356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1593" mass="175260" checksum="29D033DF951B3D87" modified="2018-01-31" version="1">MEPSSTALLADLSQVPLTTHGVIFASVAHSLWINSLLFPVYVAAISGVTLLVQTVIHAFRKAGHSEGTELQNPTPASFPQTLESLGGATIFVFKLVQLLAVLGLLGTSLAQLILSNWDVVSFNVLGPIQVVRIAQCALYAYLAVLGSLALFARSPLNSRAYVHASWLLVLLWGVYMYRDVYPLATLDKTPMDSTEGPIFYVKFALLTIAAVLVPVFIPRKYVPVNPKEVFEPNPEQTASLGSLHSFTFLGPIIWTAWKLPHFTYDMLPSMADYDHLRNLAKQSFPHLDPTQNKSRTHMGLKLLWVFYSKGVEFLHLSAMSVAGALFAFASPVAIQGLLRSIAYEWFMFKQTRVSVRIQAIVTELVFEHALRIRMKAETADASKSSNTAVVTPDTASQAGETGEGEGSEDSQSSTDAPAHSAISSLGTTIASSSVKGKGRAAPEDSSRKTAEGTNSVEDKKDSKNLVGRINNLVTSDLNSLEPFAMFVTYATFEAPIQTMLCMVFLYNLLGWSAWDSALVGLVMMLITVPVPGGIIKLIQGSQREKTKKTDARVQSITESMNVIRMIKLFGWEPRIAKQLNQKREEELVAIRKNRLLSMLNYMCNHFFNLLFEMLRMNFQLSFIMIPQLIQAKVSLERIQDFLLDTELIDEFTESEPEAAELPPSPVPEEYRNTIGIRHASFTWANDSTRLAVTPGGTRRRMFMLHVDEDLFFKCGKLNLIVGPTGSGKTSLLMALLGEMHYIPSGPDSFFNLPREGGVAYAAQESWVLNDTIKASPIARLGDDRSANKWRYVRTTSSSALRSTRSGTRKVESVSIPFEASTYPVYVVIKQCALERDLSLFDAGDQTEVGEKGITLSGGQKARITLARAAYSSAEILLLDDILAALDVHTSRWIVNKCLNGDLLHGRTIILVTHNVAMVSPIADFVVDVGSDGRILSQGTLENALAHDSQLLKDVEHEAEQLQKTDQESEIDEEKDEDVNAESRAGKLIVAEEIEEGHVGWAALWLYFGNVSTQPILFWLVYATGYTLRHSFTNVQSWWLGVWAAQYETTAPEEVQVPYYLSVYCFVTIAVITCSAFSVWFFVGGSMRSARIIHDKLITSVLGTTLRWLDKTPTARIIARCTGDIQTVDTGFATTTELLMETTVFLLTKIFSIVVLSPIFIIPSVIAALLGGIIGKIYMKAQLCVKRELSVAKAPVLGHFGAAVSGITSIRAYGAQESFKSEAYRRIDRYSRVAITNVNLNRWVTIRVHFVGNTLVSALAIWLLYFAPLSASNTGFSLAMATLFGNNLLYWVHIFNQLETSGNSLERIQQYILIEHEPKSTPAGIPPAYWPASGNLEVKNLSARYSPDGPKVLHDISFKVASGERVGIVGRTGSGKSSLTLALLRCILTEGDVRYDGLLTGKINLDALRSSVTIIPQVPELLSGTLRQNLDPFSEHDDSVLNDALRSAGLFNLQDESNESRITLDSEIAGGGANLSVGQRQVLALARAIVRRSKLLILDEATSAIDYETDSIIQRSLRTELGKDVTLLTVAHRLQTIMDSDKIVVLDAGRIVEFGSPGELLKNEKGFLHALVDESGDRDRLYSMAAAAAEQSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6T2</accession>
    <name>A0A2G8S6T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6T2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6T2"/>
    <dbReference type="OrthoDB" id="2756261at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="555" mass="60889" checksum="127B794AF97472B4" modified="2018-01-31" version="1">MTLPPLRAPPGPASAGPGAGSTNPSSKTPSSSRPLLRWADTLSSRMDKDLQLPPDAKGPWHSALWLRKALPAHLKTVPTFFADRPALHRLAASTLRDGKLQKKLAKEAAVRKSAEDALRSLNVLASVDLIGLSPSESVDSAPQVPSGTHSLEAEDTTEEPGENTRYQDDEEANIARDDSHHQLDGPGPSTPLHGATTHGVETPTGTPSRALTPASGHDSLWEFNTDNAETGQPPAKHGRSESQSEDFGPRVPHASHLLRAIATDKCHTANLNGEQTNDALTFCDLTIAEMLVDIKIHLLKNENDILARYFRLYHRHPDFTARTLNTNHLTAVADPRAVQARLRGLLAAVLFAHNTPAYLNNITNSIAEYIEKHLDVVALTPQCRDDPVDWGLVKSAIANEISQLRSALKSKLDASVKNQEDIYVLTTTALNHDIRPKEQHWARFAFLRHCAVEFKNLGNTVTAKQFWPFVDNKLAEVRKKLKEVQADRRKESETKFFADLLRVDIQLYPIKSGAVEQQAYTNAKLRSIQVAMESAVAGFVVHTGVEAAAEEADEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6V2</accession>
    <name>A0A2G8S6V2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6V2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6V2"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SUN" evidence="5">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="165" mass="17972" checksum="70AA430E5D6D1BEE" modified="2018-01-31" version="1">MGAQISSVPPDPFNPNRFLSADATGAQFQVGVSFATTIYPTHFTIDHAFSQDIVGSSNAPRHIVFWGIVEGVGNKGRASRVVGDLALSGVFNRTVPNLHQRENFLPLATVEYDIRGSSHVQTFAVHPSLVESNIDFGVIVLEVLDNWGGEVTQLYRVRVHGLAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7F7</accession>
    <name>A0A2G8S7F7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7F7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7F7"/>
    <dbReference type="OrthoDB" id="2801156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="462"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="692" mass="76997" checksum="0303AC186D3BBBDE" modified="2018-01-31" version="1">MNFHPFYETIELGSGDFDSVTAILEKGRRWMQAPRRGYYDHWGPILRWITDKSTAFVRKDDSDVSSLREDAKAWYCNKGRCLTSEPVDTDDTLWKRLHRGSASIATGELEIQLYLVAPATRPTKVRFDTGVHAEQIRRMYILDYQPVSEELWYPDSDGSDTDKDNSILTRMAALYEPAFAYAQNALQRGLQDVPLSDSGGNHEEEGNAGSVVAAGDAMVCDAIGEDDVLDTHLFMAQLRDALNGLKAGCPDSESEEGASAHGVALGKVLQLPFDDPTLKVQVKLTSFGRRGGPLPRIKIEAECPTPCRIPALYVVADDRLTSLRDRNPKRKEWGMQESMIAYRDTILITGRAPIHEATCSPCLVIGTAGAAIRIFAAYFADRIYRTHLCDFALDVDEHHDTRAAALAAKVRVIRNTARMLREMYTRVHVGAHILPPNHTCRPHLLPRPAILMPVPAPLPVHLSLLERVTRGQNSYVFTGTLTLPVRHGTDDSAQSSERELPVHVKFVPEYSVAAHRLAAHTDPTSGAPRPLAPQLYWAGEVVPGLLMIVMETLPPDARMLWWWHSNTLGRRVDRYPYDDEDFTPAPQYQPVRRAELGDLRAAVRLLHAHGFVHGDLREVNVMLHTVGLLQQGAECAEGGLGCRQRHTCGSLAEIYFLAASGSLVLRAGRVCARDEERKKAVDYRGLRVSIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7H2</accession>
    <name>A0A2G8S7H2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_08171</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7H2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7H2"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="557"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="383"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL29732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="676" mass="68757" checksum="C68F3F9A200C48B3" modified="2018-01-31" version="1">MKRAAEKQLVKDGRDDDEEEELEEVSKTGFKKADESVLAGRQIKALPRRNGLAANAASVRAPSATTAEPTPPSKFAGFSGFGAPTNTSAPFSFASTSSAPPAAPKLTPAVPAASPLSFSSTSAQPPLFGGASVSSSASPATKAFASIVGSSSAESIPPTSIEDDQREVDYYKALRGLNVSFLSAVSKAIESDPFVDVADLLERYKALRVSVKSDFDEKARPAAKAPTESKPAEAPKPPPAFSMPAPPASYAGFKSPAPASTAATSPPTGGGFVPKLESSKSAPSLGSPFSFATSKPAAESSATSEPPKSAFSFGSTTAGTGPASGSAFSFGAPSSSSTSIFGSKAPGSSSTSLFPPSTSSTSIFGASSSSTSIFGSGSTFGAKPLAADSSNDADDEKDEKKPSVPFTFTSSRSSTPFGAGTGATTPEKDKDKEQAGSGFSFGSASPGKPSVFSGFGTAKAGSIGNPVGFGFGSPPRTPDIDGAAGSSADSGPVKSLPFSFGAPKASPFAFGSGAPLTTSASGEDKKEGGSSGEGTPAAEEPKPLLASSSAHDLEGEGEEDEETTHEIRSKVFKMTKDKDGKAQWGDLGVGMLRLKRHKETDARRVLLRNSGTGKITINFLVHGGLNPTVSDKVVSFMGHADGASTPYRIRCKTADQAKDLKAALDRELEFVKSKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7J6</accession>
    <name>A0A2G8S7J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7J6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7J6"/>
    <dbReference type="OrthoDB" id="2803499at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="115" mass="13328" checksum="981DE413230E110E" modified="2018-01-31" version="1">MEQAQPDHLYYALHPDSKYFHAKESLFSDETPWNQSPTEYVKLFTTLLPERNYPTTIIGEYNDAFKAVLKSRKYPDIRFLLIDRPTLLRPDAHATGDCLHIMSGAGVLKAWSHYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S846</accession>
    <name>A0A2G8S846_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S846"/>
    <dbReference type="STRING" id="1077348.A0A2G8S846"/>
    <dbReference type="OrthoDB" id="2749208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53987" checksum="961B1607A8815647" modified="2018-01-31" version="1">MAVWSEHIPLNIAGNDISVLGQLLLNTRRRFESVHLYDIASNDLGPLRSTVIREISSPSLRSLSLFSDFIARVPVIEDSARNRLPLTPEHAPNLRFFALDDVELLPANGFSCLTHLALIDSWVYTSWSTAESPENFHSRLLKFLKECPRLESIVLMNFVLRLAEGEVLREPAPLPLPHLQHVTLCNFDPEAIRYYVSLLQPRVDGSSIQILGYHPREPWFPGHFLLPPDSTRADAQALKQICVGVHTRAPHNPEYSISVTTVSSSSTRRLVARSSQLADTITPYDWPSSILSQPPTASLPLPMEEVWLYGFSGTTIPRIHSPLLHLPHITRVLVLATDRRLHYDDSDIPTLRHLPTALDLLPGPISISAVRIVYGFSEPSEPFRERSPFDWHGLGPAVNLYHLPLVQLVDDLRSGAYAYLKHFVLQATPHMWVSEDELAAVREAGRFETFVFEHIATFPEMPGHSDPARKERFPNPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8B5</accession>
    <name>A0A2G8S8B5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Haloacid dehalogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8B5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8B5"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019120">
        <property type="term" value="F:hydrolase activity, acting on acid halide bonds, in C-halide compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006328">
        <property type="entry name" value="2-HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01428">
        <property type="entry name" value="HAD_type_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF3">
        <property type="entry name" value="HALOACID DEHALOGENASE, TYPE II (AFU_ORTHOLOGUE AFUA_2G07750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28316" checksum="2DC31A3B0A455D71" modified="2018-01-31" version="1">MSGTDTAGPGTNPLSGVEAYVFDVFGTVVDWYGSVTRALEAFAPESLKSEDWGSFAKEWRKGYGEYTKRVAHGGKGSSNADVMHREILDGMLETARWKHLAPVWGDAQREELVQFWHRLDGEKAPGRWPDSSAGLYAMKKKAIIGTLSNGNVRLLVDMAKHADLPWDVVFAGELLGSYKPNPKTYLGAVHHLGVTPERCAMVAAHIYDLRAAASHGLKTVYVRRPTEDADVRDSIKSKAEGGEVDLVVGSFEELAALMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8C3</accession>
    <name>A0A2G8S8C3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_07944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8C3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8C3"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="611"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL30032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="640" mass="68350" checksum="3DFD19A4A267CB8F" modified="2018-01-31" version="1">MDVNFHLGTPPGTLTCPSSLPKALKHDLSPAGPLDDDSLIHTTPPLAPTPSLQFATTIMSGSFLTTLDQVSGKAFDYIIIGGGTAGLVLAARLSEDPAKSVLVLEAGGAHLGDPMIDLPASYGKFFKNEEGKGLGGSSATNFYLWNRPGEEDVNAWERLGNPGWNWKNFLKYSIKCEKLIPASEEASTAERLTYDEKLHGADGPVVLGWPNMRPGWDVVLQDTLEALGIPRIFEPQGGDRVGSSMDLSTVDPRTNKRVTSVAYLEQAGTRPNLKVLVNAPVARILSVPGEGFTTSGVEFLFGGEKHTVSTAVNGEVVLSAGAIKSPQVLELSGIGDTKILNALGIETKVDLPSVGTNAQDHLFAGVAYELKDPEKYNTIDPLLDPAVAEEHLKLYAEGKGLFTLGIVGISMAPLKSISDNAGEIESTVPTGGDAPGLAEQRAEQVARFKEGAANAEFVTIPGFYSFPNPPSPGAKHVSVCTTLNRPFSRGTIHAASRDPLAPPEIDPHYFEEDIDRLTYIEQVKFVRKLAQTEPFASLLGREVNPGPDVRSDADISLWLKKYLTTVHHTSSTCSMLPRDKGGVVDPELRVYGTKGLRVVDLSVVPLIPSAHTQSIVYAVAEQAADIIKGNGLYITAKCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8V1</accession>
    <name>A0A2G8S8V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8V1"/>
    <dbReference type="OrthoDB" id="2757774at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="563" mass="63390" checksum="8867C856E634F45A" modified="2018-01-31" version="1">MARSAKLNVDVVAIVCEFFNDLSDVLSFSLTCSTFHRVAIRRLLSMRPVDLKGGTSTRKFYDFLLAEAHTHRAPLIRALNIDIKIGSPETHQAAQQNDASILLDILSACAQIQFLSIPVQPARYSITDYPHVVAAIGALRNLRSLSVHVWLARQLALFHAVNAPVRKISRHSMLSSDPEVRGRWSSSILEEFLPRFAPTLEKLELNKFITDEDSAPSVFDMTQYPAVRSLSVGSISGTPRLDHLQRLFPALAGTLSLGRLDLKFSFLPSEDTRFEILTNMRAENEQAQERLGSRAWKKVDRVICDARMFYVLRLRYPIRLVMLDSCLASGGDSRYARYALRENPAPRLKLSMVLDSSTLTGLGEIFSPELTGMLTHLTLCLVYANDFLCTTAAQAEAFATIRWNDLLESMASKLRPLHQLTHLRIIIRSQVYQDETEEALAYAQHSEEFVRALRRSAFDFEGTAASLLGSPPSLRYLFLTTSSNLADTDRDWRTTFERWHETRAWRIAGSGTNEANHVEPLLVSLHDQVVKTIIRKEELVLSDTDTSSAYCNVAGKILFQDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S907</accession>
    <name>A0A2G8S907_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S907"/>
    <dbReference type="STRING" id="1077348.A0A2G8S907"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="213" mass="23360" checksum="7B272C6943F6755D" modified="2018-01-31" version="1">MDDYKDLISPVSPLVWFPTPCNGTQTLNFVRSPLSAGPLSRACLGSLPSGFSVITGMYSSMVPGKDVQAPTLDRCIVVVFGRELVEELRTRRDEESLAPEGAQETITHGLTRLAEQSELLEPLRNEIEKSVAADGWTHAAHPSMWKLDSLLRKILRFHGISLLSMGRKATKDLTLRDRTPIIMPAATEQLRAGRLALAIADGPNKFLQASNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S957</accession>
    <name>A0A2G8S957_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S957"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="342" mass="38094" checksum="3AD2CA7222199609" modified="2018-01-31" version="1">MEVTAGWQSELSACECQRKERGYSNVEDARECEGRRSRRRRRLGHAARRRSEPERTAWKQLTPRAPRWPPRSTIYQTRCKIPRRSCLEPTVENHNIPYTLADNPEQYLRVYLTGPNSTLKWMMMTPSLPTVDDLPWGTEQKNPPVTVTGGPLEDWSTKGTALIERKSERYRCTHSGLPCDTSRASRGGPLKTHRLLVKLTVNESGIIVRALRTLGFSFPALLDAAPPFAVLEQNPVPAYKVPFAYVQGASPYVALTLALAHSLANRIPTSPYIHSAMYGRACGMRPNIGLPSRWAKPEGTRGWGRLGGDQGGRNAPCGEDGHTWSMQGRLAVLVQISSLPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9H4</accession>
    <name>A0A2G8S9H4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9H4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="143" mass="15809" checksum="752ACBF7E1A4A70B" modified="2018-01-31" version="1">MDIVHGLEQLPPASSQDDLASKGAGLVGFPHTLEPVLVQLLQNRFHNRNSASQSAQVLLVTSMALHLKNVAMRDARRRIVLLKPAWMSGHFPELLTGANEDVQFYTDLKAAWQRRVDGLESAVWDVEQESVLASYGHRAGGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAK2</accession>
    <name>A0A2G8SAK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06948</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAK2"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000003">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="9">
        <location>
            <begin position="463"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="278"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="577"/>
            <end position="579"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634015-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL30780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="623" mass="70569" checksum="B7ACCF6A86BBB012" modified="2018-01-31" version="1">MSLPYDPCTQANWQEVATENVDFDWTVDFAQQTISGSATHRLRVRKDNVPHVIFDTQALSVTKVIVEDRPADFSLGKHHDVMGTPLTIPLPVSRKVGDEVRVQVFYTTTKECPALQWLDKEQTQGKTFPFAFSQAQPIYARSLAPLQDSSSVKITYTAKVASVLPALLSAIRVSPPSDGPAHDGKEIGKDWVTYEYKQPIPIPPYLIAIAAGNFRYRGLPKVEGKTWTTGVWAEPETIEAAYWEFSEDIQKFLITAETVLPPYRFGVFDVLILPPSFPYGGMENACLTFLTPTLLVGDRTLANSTHFWLNEGWTTYIERVLLQLLHTPAERGFSFLIGYKSLQDALKQYEDRPRYQRLVIDFQTGEDPDDAYSTIPYEKGANFILHLERMLGGLDEFLPYIKEYAVTFQGKSITTEDWKAHLYAYWEKHGGPEKIKALNSIKWDEWLYGEGMKLPVEMVYDTALARDAYSLAEKWDASRSEDDLSKLSFQESDVTSFNANQKGVFLEKLQSYPALPSSHVTYLGKLYGLSSTPNAELRWRFYEVALLDPASPAAQEYAPEAARWVTGNDGTHIVRGRMKFCRPTFRAIARADRKLALEYYGENKLSFHPIARRLIEKDLGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBI4</accession>
    <name>A0A2G8SBI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBI4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="113" mass="12082" checksum="87FC6FA71D0483A5" modified="2018-01-31" version="1">MQCEADASLNVIEEAENAERRTQNASLPALALDLEPDHDFAKRRLPMGGCNNKNPAYESAGGWPLATVTVTIERRATSMHMVDGLRLRGEEGEGEGDGGKAKAKAKSPCLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBR9</accession>
    <name>A0A2G8SBR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBR9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBR9"/>
    <dbReference type="OrthoDB" id="2758370at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43593" checksum="6A11BD48A416D272" modified="2018-01-31" version="1">MPALEVLLLHGPYYESEILDVPLTHDLVPRLTSLELWNCIAPREAAVYTPLRRLAFLGTKWASSYDEFLDVLCNCQALEYLRLDEELLDSFAEELASPPSDIRRRMMPLNLPRLKTVEFSGQREALFHLLATIHMPQATTVELTNCLDDDEPGPLIARLLAPDPQLRIPFLASLRTVSLSCWDGDPFEVSLHGGPDGNARLSVDYGMVHNELWPGNSYLEHNLVAIMNIFSVASVHTLEVEGCLDLVAVETWHRVFLAFSSLRTLHVKGRGTLDSLWLGLSRATAASLEHDGTACCPSLAEICVDDRPRVASRFKFAATAQLLETVRGVLNARARAGCMRVKKLQLYLEYTDELWDQTCELREGFVEDVKALVGELDYREAISKGPYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCM8</accession>
    <name>A0A2G8SCM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Spindle pole body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_06216</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCM8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCM8"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="12">
        <location>
            <begin position="48"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="173"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56123" checksum="A2ECDADB3F9863E7" modified="2018-01-31" version="1">MSPAARHTDRTEDSDRPTKRARVVDEDGEEDSEDEILPSKVRGEPQKASDLYLDTINRAVLDFDFEKVCSVSLSNINIYGCLVCGKYFQGRGRSSYAFAHAIHDDHHVFINLETTKVYVLPDGYLVSDPSLEDISFVLSPTFTSTSVSTLSTAVHLRKPSYDLSNKPYIPGYIGLNNIKRNDYMNVVIHSLLHVAPLRDYLLLSNFRGKESELLKRFAGLAKKIWNPRLFKSQVSPHEFLQEVNRASVGKYSLEKQGDPVDFLGWLLNRLHKDLGGTKKKNSSVIFSTFQGEVRMETQQVLVRPDTGGNEKPRFDIDREIKSSASPFLFLAVDLPPPPLFQDAVEKNIIPQESSGQVRRFKCQRLPRYIILHFKRFTKNMFVEEKNPTIVNFPLRGLDFKDYLDAPASHPSAVYDLIANVTHESAAGTTRDKESTVWKVHLRAGTGGGDTERWFQIQDLIVEEIRKEMIFLGETILQIWERRPDAPPRLRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD17</accession>
    <name>A0A2G8SD17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_06345</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD17"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD17"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="338"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="92"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="760"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="805" mass="88176" checksum="8ECD0DDEB2BA734B" modified="2018-01-31" version="1">MLSRSLRARAVALSRRRAVPTLAPSQFSRFYAAPSDSYPPPDQKPPTASKSSEESGKQQDGKVENKQPEGKDVESKQEPLKGLDGFFQRYHQQQAARQSTGSSQQEGNENKSQQDGNRRNKQENTNNSNNNPFNPNQLAVIATTAAIFFALSSTSFSSSREITWQEFRTAFLDKGLVDSLTVVNRSKVRVKLHSNATGAMYPNAPSGGGDYFFSIGSVEAFERKLDEAQQELGIPSHERIPVSYHEEVSTFSYLLSFGPTLLFAGIMIWLSRRAGGAGGGSGGIFSVGKSKARMFNNETDVRVRFNDIAGMDEAKVEIMEFVSFLKEPSRYERLGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFYSVSGSEFVELFVGVGSSRVRDLFATAKKNAPSIIFIDEIDAIGKSRGKGKGFGGNDEREQTLNQLLVEMDGFGTQEHVVVLAGTNRPDVLDSALMRPGRFDRHITIDRPDVVGRRGIFMVHLKPLRLSDTLPEREKFAEKLAVLTPGFSGADVANVCNEAALHAARVGHDAVTEDDFEAAIERVIVGLERKSRLLSPEEKKTVAYHEAGHAICGWFLEHADPLLKVSIIPRGVGALGYAKYLPPDRYLLSTPQMLDRICMTLGGRVSEEIFFGYENITTGAQDDLQKITKIAFEAVANYGMNTVVGPVSYGGANATQESLVKPFSEKTAEMLDEQVRKMIVHAHQRTTVLLTKHKEDVEKVAQLLLEKEVITREDMIALLGPRPFANRKDAMDKWLEQNSQERSAPPPLESVEPTNAPPDPSPSPAPAAKRIDDASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDB2</accession>
    <name>A0A2G8SDB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDB2"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="290"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="972"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="433"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="515"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="809"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1132" mass="124562" checksum="8E3481DFEF43246C" modified="2018-01-31" version="1">MDLPPKTPVCIGNLSATALVLYPIPYLNPPDYSSQDFEWAPVRLQYEHLENKPSGQSETINIRPPSVKGSSGEIVPGETFAVVEQKIATHLGPMLGKGLIRLDAKIRRGNRTLPILQMQMLVFTPKGNIPVVSQYLLSNGLYLDHPTLPCDVQHASSGYYYNPHNPPPGGHSRSGPSVPTRPGYMGPGGNTFSRWSAPAVSGRSVEVQRSQVDELFKSLKGGDELEDADPPPEVATKLYPHQLKALTFLLAREQELAGACRRQTSLWQERVNPLSHQASWINIVTQAEEFSKPFEAKGAILADDMGLGKTITCLSLIAATYRTARAFAETPLTPPPTPPPRTSDAPLTASHFQGSVWGIPPPSIEPHASSASSKANKKMAKEQDRMEAQYTRACRIKMKSRATLIICPLSTVVNWEDQLKEHWRGEVAVCGGQSGVPPPASQLSTSGLSTPTGSQLDIKAEEKKPSLGRVRDGPVLRVYVYHGNARRCDPTFLADFDAVITTYATLASEFSKQTKSLEAVDDDDDDDGDGVSSEGFIEVDNYGQPVTKSKGKKAKKRKKAASSSAEATSPLQSIHWFRVVLDEAHSIKETNTVGCRASCDLIADRRLCLTGTPVQNKLDDVFALIKFLRLAPFDDKNTWNEFIGTPVKYAQPLGIARLQTIMKCITLRRTKESRAEDGRKILSLPPRSDELRYLKFDQQEQSIYDQFFNESKAEFHELSHKNEVMKNYVGILQKILRLRQICDHFELVQNKGLGLPGDALTSYEDVVATVAREGINAQRGGMIFALLKEAGTTQCVECQGELSASLETTNEGLAEVDSTPAKRGRKPRASASTSRASTRQNSPTVPQPVLTRCQHLFCAECFRTSTFPGWPNVQPDTPQACAICQTALLPNDAVQLSLDCAILDSFISGGAKKKPGKKEKRQKGIAIEDFHPSTKVRALLGDLIQFSKANPYSANYDANSVEVQMVDGDGNCIDEGVTKTVVFSQWTSMLDKVEDALEVANIRYDRLDGTMKRDERTRAMEALKHDPGCEVLLVSLKAGGVGLNLTAAQRVYLMDPYWNPAVENQAVDRIHRLGQTRPVTTVKLIIENTIEARLLEVQKKKTELANLTLGPPLSKSDIQARRLEELQQLFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDU0</accession>
    <name>A0A2G8SDU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDU0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDU0"/>
    <dbReference type="OrthoDB" id="2803586at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="602" mass="67172" checksum="398717EE0A9F1C82" modified="2018-01-31" version="1">MAPQPQRKPPIANTSLPATTTTSSSSADYPLHHLLAMGIFEPECVRQQCAATINNKEEQLKFIETWKDNAKRRADGWGKHREHQSKHMQLLRWIAKYAEYLTATTNAMQASLMSDDSVALDPRWPIIGPEAEPPTYLHEFFREVTPNIEPETTYLKSCYAVHWIFHDVLRCCPKCKSKRLESSGWNQSGPREVHGLFREGMAISVQLRCLACAAKHAKSGRAGRSSESSEEGRYCWTTTSVEFWENFEHWELPVGLPHFFSRSAVTAELYDFIVEMHLKSTSAGLAENVKPNVLGEAEAAGPILAAGEKEVGKQSGGFDNRSISDDQITAIFLKFSNQTRIEESEEHMRTLSAYGSPPTLTPGAFLAIAISIDTTFRCAYKATLVDKNKARVKSHLGGFVSVINQKSQPISWQLCHSQSQTETQEMLSGLSTRLSCLELPSPEIMTSDNCCQIRNTALSVFPDIQVVQDVWHLLMRYLVCIKDGTKNPHRGEVARDIVDAILKAKSANGVPAIYHSQPEQERRLIKAFDKWQEHGGVWTAAAVKVHAKQLAHVQKGCLARPRDDIATDGSRIEGSHKGWNSIMQSFPSGLEVMNALGHDHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFJ1</accession>
    <name>A0A2G8SFJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="6">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF32</name>
        <name evidence="9" type="ORF">GSI_05248</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFJ1"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="315"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="771"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="590"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="771"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="793"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="818"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="841"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="978"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112993" checksum="97000D483A58043F" modified="2018-01-31" version="1">MAPFSKPETVLKQAEGLVSVGQTHAALQSLTEMFSSKRFRSTPLASLEPIMIRFIELCVELRKGRTAKEGLMQYKNIAQNTSVASIEVVVNRFIQLSDAKVQEAQAKADKAVALDVDDLEASETPESILLGAVSGDQTKDRTDRALVTPWLKFLWESYRTALETLKNNARLETIYQQIAQQAFRFCLKHQRKVEFRRLCETLRLHLGNVAKYAHQPHSINLSDPDTLQHHLDTRFAQLNTSVELELWQEAFRSVEDVHNLLTMAKKAPRPAMMANYYEKLTKIFLMSGNALYHAAAWGRYYAVVTATGGKSEEELSRLAGQVLVSALAVPVGIQGEEGVEESKGKNARLSALLGLTRTPTRSGLLREALSRNALKLSPKTVKELYGVLEVTFDPLTLSSSVTPLLRSLASDASYASYVPLLQRAVLSRLLSQLSHVYSTIKISNLIELVAPLRAVAAEGTYDDEQIEAYVMGCARRGELNVRVDHAVGSITFADSPFAAVEDPSSSTSAAALGAVQPSTSEFVRNRLGSIALTLHNSLAVLEPPAQPTEEEQQAQFAALVSAAQAERKALQIRRALVARRRELVSELSVRKEKEEASRRAEMMRKHQEDEARRAAQDLRNKELERARREIENIRVEEAKKLAQSLKDKGTLKVDINDMESLSTDNLMRLQVEQLEKEKKELNEKMRVLSKRLDHVERAYRKEERPLLAKDYELQQANDRIVFDASQKARLEAHRQAHQQDVETKRRMTRMVSDFGQMKDLIGARRGEEFAKKKELASKKMEEEKAKRRAAVLKAREVERQRLEEEERIQREQEEEEARLEAERIAEEERRAEEEAAAQAAEEQKKREEEERAAAQRKAREEERQQAMEAARRQQEREEAAMRRQAERKSVAQAPPPARAPVREETNTWRRSGVPSGRTGIDTPPRSESPAPAAGKYRPGALGGGGGGWRAREAAKQQSVAPGDATPARPASPAVPPPAREEPAKDEGFQTVEKKVWRGSRLQARKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFL4</accession>
    <name>A0A2G8SFL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_05267</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFL4"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013426562" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="15">
        <location>
            <begin position="83"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="765"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL32564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="828" mass="91516" checksum="78E1A42BE95CC948" modified="2018-01-31" version="1">MRRLFVAAVAAAGLAGALAHDSHAVSRRKTLSFGPILPHSSYHTNPVYHTSLLRAQDPFEVAQIFVEDLIRDIPGGSYQIREDSYTDQATGVTHIYARQYMNGIEVADGDINLNVKDGIVLSYGDSFFRPQNGASLHTVARDVDPHADYCRALEREVVSQLQKVDVSKPDHGVDREALGQLGDLYDWNCQFVNLPDFMAESPDFASAEDAASGDVTRALLQFMIAATPSEDMSAEMLANTAKYLSEMRVTFEHHLTGDHAPTFTVDNVPDAVNPVKGRLAFVQVPNGDETTLSLVWKFEVEMKDNWYEAAISAEAPHRIISVVDWASDSPVPVAPIPPKDQEGATYNVFAWGINDPSVGERSIQKENFDTLASPLGWHALPYSNDPQSKNLRLKDASAIRNTTTTWGNNVFAHEDWEGRNNWLTNYRPDAGSAKVFDYAYKPKQTTTDDALEEAQKYINATITQLFYTSNLVHDLYYRYGFTEVAGNFQQHNFGRGGQENDAVIANAQDGSGYNNANFMTPPDGQNGRCRMYLWNTANPYRDGDLEAGIVIHELSHGLSTRLTGGPANSGCLGWGEAGGMGEGWGDFLATIIRSNKIYSDYPMGSWAANIDKGIRNYPYSLNDTVNPSTYKTLDKPGYWGVHAIGEVWAQMLWVVSQRLIAKHGFVDDLFPPKPLEDGTVPEGDFYRAREYDVQGNAKPLVPKHGNSLIVQLVLDGMKLQPCRPSFFDARDAIIAADKTLTGGENFCELWQGFADRGLGVDSKVEGRTPWGGGVRTNGARVPAECSSDVPPPADPTPGDGDDDGDDDDWPWFAWVVQHSTPFMWLWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFQ5</accession>
    <name>A0A2G8SFQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFQ5"/>
    <dbReference type="OrthoDB" id="2757957at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="760"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="817" mass="89372" checksum="7B90BAA78A3A55BA" modified="2018-01-31" version="1">MSHFFPAYIGKPPPHVLRKRRQREQEELARQEREDREEREREERDRELSPEVPEPEPSTPAHFERTSVFGTPTRSVSRVRKTYAHKRARSFATPRMRAGSDGEHEQESQTSSREPSSSRSPTKAAQKKQAQDTDSARPAKRPRLNEYDDDDMYADPPMLEDAIAPVASPSHSPVRRPQQNPRAGSPEAPEPQPSTRRPRGRPPKVKPIAIPTPSTTSEEGVAQNAKRRSAASGTEMTLSEALNQSFAHSLVPSPVVASSSRARKARNEQEDMRDPSHAEPTPVKRGPGRPRGSGRGRGRGGRGRGRGAGSSEPFASHDADNVFPPASAHESEASMPTWTTLPTLDRGAASSHRPPHPLAREEEEEGSDDELASVTQIPVKRTPGRPRRPATPGSSSKAGDTQPVKRRGRPPGSKNPATLAREAAAAEVARRRASLPNLPASSTSIMANYAAAHGPPPVTPVKRGRGRPRKSAPEPSVFGLDTVDYMEPLKDPDADVDDNPFRRRTRSQSRTRGSARSTPAPSPAPTPRRRSVSATRAPRTPRRNNSKARPEAAPPKSDAPKSSEPPSHYLDMKTMEWKPRARSTSTSPPKRRARPTPVPTEMPKATEFQTRTQLCNALKRTLLEAPMPKLKDIAAENEKQQRRQQKEKERLKRKRDADRLKVAPSGVLFFGSGDKSEAEPDDEDDDDEEQGDAMTVFCGSWSVLADPAATFDDSLAMKTLHEVVMGVRAYIELEKAAFAKSHDGQTISVTVPCGCMSVRGRTSESPEGGSSSSLQPPAGDAEQCAGKMVVSVTQELIPEGFSGVGKAMRMTVMISHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG72</accession>
    <name>A0A2G8SG72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG72"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="102" mass="11422" checksum="37D287E48E114424" modified="2018-01-31" version="1">MLTALAFPSVYPPHLMVQFSGIQRTQNTSISFVYRSRMAVFALVKRREWAQKCGNPVKSITPGQPLRALRHPVRACSRDATFKLAGAVETYKYHVDVSLANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH39</accession>
    <name>A0A2G8SH39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH39"/>
    <dbReference type="STRING" id="1077348.A0A2G8SH39"/>
    <dbReference type="OrthoDB" id="2859538at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="597" mass="66762" checksum="326484BD6FBCF747" modified="2018-01-31" version="1">MYGLPFATALSTALSMLPAADRTGLGDSELSISDMRAWSMAKAGEHYKYTLAFRAIQNILAPIHRLPPEILSRIFVEAWENRRSFRLTHVCRLWRSILLNTSEFWAVAISKDQFRLSPSDDSNWEDSNAEDYFGAAYLRSAPRDISLNLSSLSFKGHLQLIDRAERITTMRFYAHTRDQLKCLWTVLHVGMPRLEDLAVRTSDKIVSWDGPKPCLSTKELPLLTRLSLPASLFPSSWPNILQELTLRSDHVPFRVCLDILFGSLEDLLSLRVLDVRDNSICSNGPLAQPFRAFPTLELLRIRSDRETVSGVLSLLTFPPSTRIDIGIDSRPPFIFDHIEEKDLFVQGSSLDGVAALVDQVTFRSGPTSTICGLTEGTERLRITASFSEWSLPYFEHAIRLFERTGAPVSRFLLTQHPGQRMCTMARSWRVLPAFPHITHLALHASDSICDDIFGDLQCRRMVPPPDTMLPSTSLPLLKELTVGVGVERGTGWLLRQPASEGNISAPGGAVAPHMRESCGLFPGFLEAGCRSGYRLSRLEIFSYEERYGMAKAYSDYIASHVDLAALAPGPVEREIAPLRAWVDGPVVFSGHRLYTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHU0</accession>
    <name>A0A2G8SHU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHU0"/>
    <dbReference type="OrthoDB" id="2756515at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27899" checksum="A403FBB0BF7D6F6F" modified="2018-01-31" version="1">MPAIYTPTPPDTDPVFFFSIVHIYVEGILFGIPNYVCELSKSESFRAKVAEQPCVLEDVAAAEFRDFLQCLIALGPEATKKAEELGEPPESESDDGSRVAYMRRWLNAIKLATHWNFEDARRKAIRKIHQMDDPPLKLAVACKYDVQRFLPDALRDLADTKIMTPLNKEDYEILGLDLALKVVQFREEWNAQTAGAGDTPEKDRREQLIETIFGAEFAKGVEQGELENLPKLFSCPVAPGRRRAQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIJ0</accession>
    <name>A0A2G8SIJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIJ0"/>
    <dbReference type="OrthoDB" id="2756770at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="153"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="28481" checksum="92AE4B2FFF65E96A" modified="2018-01-31" version="1">MRTHREPTPVISSSSSDDEEEEDMGSDPIPAFVLPQPESPAPSPDRSDPDDDDNDDDDKEEESAEESSGQSSDEVEGVLRAARTDVAQLCWEGGASLIQFLIAKAIPPDEGEKVPPANVREWTYRDIASLPNAERKEWFTACREELEALRRRDVYDLVDRPKGRKVVKNRWVFDVKTDGRKKARLVAKGFSQVEGEDFDKIFSPVVCFETHSRTGTSQDSMCTVPTCMANWMRRSTWSSQKDFASLALSTKSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJX4</accession>
    <name>A0A2G8SJX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJX4"/>
    <dbReference type="OrthoDB" id="3181072at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="257" mass="28454" checksum="9C227679106976A8" modified="2018-01-31" version="1">MSDDATATPVAVAPSVDTAAVRELLGMMKATLGQLDQTFRTLNEQSAQVKSLGPTMELAVGQLSSLRHQIHAQEKKQEVRVEEIRRMIREDIKLKVADEMREQIRKQVPLEIAKQAREQIGLQIRDVLPVSLKTQAKESRDYLEEVKHALENSEARRKNSVLKPSPNNLADGLAVVLKPDGTKSKLYPANLRSLFAYDYGKSKELVQDFGLHDHGVLEKNLNGFMAHIGIRFFLVPVPPTDATKTGGGAVLMPVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJX8</accession>
    <name>A0A2G8SJX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJX8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJX8"/>
    <dbReference type="OrthoDB" id="2831684at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013963690" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="369"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="474" mass="48574" checksum="9A0C6828CDD79BB7" modified="2018-01-31" version="1">MARFPALLATLLCACYVRAVAVPSTPPSGAVSVDPSLVSVSIEFFAFPGYTNITGSNNCLANLATLRGAQPAIRIGGTTQDRATYDSSLQTSVNYTVASPADAPTTLTYGPSFFSLANGLKGDVTIGLNRQLNNQANSLSAGAQAKSSVSRLLALELGNEPDLYSSSSPIASGTGWSNSIDISNEANWFTALAPTLGNIFQGAVYLSWSTSTLISSIGSAGLATIKTISRHSYPQSACGGASTNLPSLMSHSGIVSYVSQYKAEATAAHNAGKKFFLGETNSATCGGGGISPTFGAALWIVDYVLQSALIGVDRLYFHHGTIGNCAYCWWGTSAVYSPYYGAAFVSEFLGTDGATLATLDSGTSAIATYAVYSSARAPLRLLVVNTNYFDGTGTRASTSVAFSGLSGSTKAAKRLTAPDATSRTDEGALVTIGGNGTFSSACVGQGTQAIESVAVSAGALTVSVLASEALIVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK16</accession>
    <name>A0A2G8SK16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03798</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK16"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK16"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000045">
        <property type="entry name" value="RhoGAP domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45876:SF8">
        <property type="entry name" value="FI04035P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="122"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="4">
        <location>
            <begin position="604"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="787"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="988"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1013" mass="109778" checksum="9653BC08719F66AB" modified="2018-01-31" version="1">MPVAPSSPPFPSAHSTPIKDKNASATAISGAPSTPTHKPFVESENVPPTPEVRLNGQRTSTSSLRSGAATPSRDDQGGGDGWGSKFWVTLVDPQTQISFFACPATGEVSWDPPVGNFLLPPSPDGEWWEMFDEGSGLPYYYHTKSGETVWERPNAFVIPLGTLQNTALARRLSVNRGIHPRTSSDTRNGSKPTNGTPTSERAPYRRSRSYVNDREGGFINAQAIGGKGVGSPLQSRRSQSSTRSSPGRTQNTNGTPSSSNHSSPRSGRRSAQSPRKSTSSAEHLHHHSQGSHGGPLSYERGHVLAPIPGSPYNTDAAPTPAPSVTGRPSPTSTPANGKPASKKDSPSSQKSKTDEGTYGRSRSKSSSYMEYRSPQPQSLSAALEMIALNSSQSSSKSSSSGPSPIPLERRGVSEPGHGSTSGSGSGSGSAAGSRSVNGSPLPKAPVRINTDSRLLSGASLSDGLGTPETPLRFKFMGLGKDKSVPPSPSRPLVAPQPRRSVSGPVPVQIRGKGISSPVLNPEASRHMKQLLDRNGGTPIPIDIYEKVGRAPSSLNTGKYPVLPHDLASDIQQFSETEFAKQYFSTHRTGFIFKRTVPVSEIMSWQKTPITSPLLNVRRELAKDAVKTFRVVQRIMGDRERERPGGVSPATSLASSLSASSGMSLALLEEERWLLGVGLSHGELRDEIYCQVIKQLNRNPNTESVFRGWQLLCVLLVTFPPSKNFEAYLGSYIQQATTQQEGRVDIMAKYCIRRLAYISKKGPRGKPPSAAEIETASDAAFHPSIFGEPLDTVFRLQERNYPDKKVPIILPFLADGILALGGTKSEGIFRVPGDGDLVSDLKLRIDKGYYSLESVDDPHVLASLLKLWLRELIDPLVPDELYNDCITNSDNPEACVQIVQRLPTINRRVVLFVISFLQLFLEEKIQTITKMTSANLALVMAPNLLRCNSESMVVVFTNSQYEQRFVHNLLLHLKCDKVDPDFVPVHGHGAIPATPTIPSAPRRSTNKRTHRPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK45</accession>
    <name>A0A2G8SK45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_03834</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK45"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK45"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013815955" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="18"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="207"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL34123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="561" mass="58151" checksum="5D42C993DCB8E222" modified="2018-01-31" version="1">MVAAGLLVLSFFALALGAPAPNVFRVHDARSAAPAGFEASGAPDANEVLQLRIALKTDSTQLVQRLLDVSTPGSQNYRKFLTKAEVAQLTAPSDDATQAINAWLKKNDVTATPGATNQWLNIELPVAKANAMLGAEFNVYTHSTTGVTAIRTLAYSVPESVQPHVDFIFPATTFPVPSSRGISSVYISGAFHNSTHAARADASCATTITPTCLQQFYNIPTTAATQKTNTMAVSSFVQSFASKTDLSNFLTKFRTDLSANTTFSVAAVDGGTNDETKPSIEGSLDIQYTVGTATDVPITFFTVGSNNDGDLTGFLDLVNTLIAQEKPPSVFTTSFGFPEALVGSDLANNICNAYAQLGARGTSIFFSSGDSGVDDGQSTACTTQFRPTFPSGCPFVTVVGATQGAPPESAAKFSSGGFSNIFSAATYQKEAISGYLTLLGQTNAGLFNTTGRAYPDISAAGVNYQVNIGGSIASVSGTSASTPLVASMVALVNDRLVAAGKPTLGFLNPFLYSTGASAFTDITSGSNPGCGTNGFPAVKGWDPVTGLGTPDFNKLLKAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK60</accession>
    <name>A0A2G8SK60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK60"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK60"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="248"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="352" mass="38381" checksum="8DCC3870FB036699" modified="2018-01-31" version="1">MGLLEDLLGGLLKCLCAGQTPLEQQNEVPPPVPHKQEVTQQQPTPIYPPTQPARPPQPVQQPQPHRPTYAQQVSQPASRPPAPVEEQWQPAPDHHKKHKKHHGHGPSQDQGSVQGESQAHTATTPPPASPPHKASSPLPSRPWSPGRPDPNQVNQHNEYYMGLRARANAAGDDMARNFDAAHAAYESGDGARAKELSNAGKAAEKEMERLNEEAAEWIFRENNTSRRVGMSEILTAYGAEQDSGPGEVDLHGLYVKEAIRFTDKSIAEARARGDSQIRFIVGKGLHSANHVAKLKPAIEELMQKHGLVAELDEHNAGVLIVSLDGRATGKGRVMGAEDLTRGLEKKDECIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLH4</accession>
    <name>A0A2G8SLH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLH4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLH4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="88"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="36529" checksum="EEDF869EAE71E681" modified="2018-01-31" version="1">MDPEYAVVVAPLLAAPSPKVPPTADQIKTHFFENVTTPMQTFHASRLPPASTYTVKNETVIVDGGEIPVRCIIPRVEDDEGHTFPVFVHIHGGCGCAGSIETDDYALRRISVDLQISVVNVGYRLAPEFPFPTGVNDCYAALKSEADQTVENAQMLKVDLSKGFLVGGHSAGGNFSAVLSHQARDDPFFAGRQITGQLLREPITIHPDSYPDSLKDELRSIEENAANPPLTSPVIRHLLHTYGGIPSDPRMSPLLYSSHEGLPPAYVQVMGLDPLRDEGIVYEKALKAAGVKTKIDLYPGVGHGFHYNFPSIALAEMVRNDVIKGLKWLLGRDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLU8</accession>
    <name>A0A2G8SLU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02543</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLU8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLU8"/>
    <dbReference type="OrthoDB" id="5566198at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="13">
        <location>
            <begin position="36"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="474"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="725"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="783"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="692"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="703"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL34756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="848" mass="91852" checksum="D0454102803EBE99" modified="2018-01-31" version="1">MVGFRLSNTTLSTGRPPIPQAYAWAAAYAATDDRPLLDMSQGVPGVPPPQVFLEALGKAASSPGSCGYLPNTGEPALREAMVQEMKVRYGEDADVTQDDIAITAGCNLAFVAAAATLVDSGDEVIIPVPWYFNHEMTLTMLGAKPVLLHTCAEEGFLPSLERCAALITQKTKAIVLVTPNNPTGAIYPPSLIAAFAKLARQNNIALVLDETYRDFITSGVPHHLFSPSESASSAGLDSGSPGLPADWDWRTTFIHLFSFSKSYCIPGHRLGLICASPDIIPSLNKVLDNMQICAPRPPQVALAPLVPTLRPFVRETAAAVAHRHALFRERLPPRWRIGSQGGYYAFVRHPFEGVHADEVCRRLAQEVGVVTLPAGFFGPQAEENAVVREDDRWIRFSVANVDDRKVEETLGSVYVFFLNIMIQTGLIRDAHNDLVTDASYDFYGLHLATCSLDQRVKVWQLDESTGSWSPEHDWKAHDAVVSKISWAHPEFGTILATASFDRTVKVWEQISAPDVDAGQLNGTGTGGSNSTRWVERAMLVDAKGTVRSVEFAPQHFGLKLATISSDNYLRIYECLEQPSLSAWQILDEVDVLSLPTATPASRSTAHTVTVATPTQTAATLDGNSVSLVSNALQQQAQQGQVPGRPGLGTREADGGWSLSWCKDRYWGEVLAAGCGIDGIVKIIQMSPSHRPTTVLSLNPSPSAAETTTTTTKTAGEGEPPKAFAVTSVAWAPSCGRSYHLIATGSRDGHVRIWRVKPPTPSEDLDDDVPEGTEKWSASIVGDFDDHKSAVGRVEWNLTGTILSSTGNDGRVRLWKMTAGNVWRPAGHISVEQAEEQQSEMDAEMAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLX6</accession>
    <name>A0A2G8SLX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03357</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLX6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLX6"/>
    <dbReference type="OrthoDB" id="2447803at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="680"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="719" mass="80772" checksum="48B9DE72EB74A806" modified="2018-01-31" version="1">MAPAGGDKARWFRIELVRWVPSAGGWCLPGSEGARDGDSEGEPVQGREWHEKIGGRSRSRLSDSQGIEKVIPGSYRSLSRAKHNAVYSPANSPGEHPGFSISSVPGPTPSSSNRCVLQTLQPPRMHPSYARSLGHIHELLAMIFSHLDDHDLARAACVSKHWAEIALDTLWFEVHDLRRVLTVLAPLTLKPERVSVAMGRLPGAYAFKRPLVPADWLRFQRYSGRVRRLCHDQRHVRSAGEKSKRPMLLHTKVFDDLAATCPTGDIFPNLQSIVWHAYASDRQPLGLAFMHRRVKHLSLHLYRSEPLPLTDYIREVCGRCQDLSSLELHLDEPVRQLEDDVSALLRGFPHLQMISLPIYCLTSRLLSELSRFHHLRTVSLADPAQAEPGDRADVTHLAPVLSNEAFPSLRSLSFSAQVANATQLLRLSSFPRQLTELHFKSVVIATSDSLQEFFMAIRDRCTSLVELSVDYIIAPDSPLHSPPPPRQQRPSIECFRPLFSARSLRVFELRWDYALNLSDSDIEEFARSWPSLASLQLNAEPVPEANGPTLTLGALLPFARHCPHLRHLGLHIDAKTVPSLPPNPHSHDVPRFRCLETFAVGLSAIARPELVALFLSQILPLGCAVGYGLRWPDAFNVAMEHALIPVCLRAEMSACWVRWNDVSKLLPIATQARLEEKGRVEALERKMVALEISRREDRQRLSSLEREVQDLRERTGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLZ0</accession>
    <name>A0A2G8SLZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLZ0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="126" mass="13855" checksum="51B96C7742221FB8" modified="2018-01-31" version="1">MPLQVAPPAPTLDRRSALLYLLREADSVDSSFFNTTTGTEGRPKVLPWSFHGLELTVKKRTLSQANSPSNITYDVNLGELLQGSNKPLLAYVLRPKSDPEANRAAFKRCLEDLAVNKAALMSQQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM95</accession>
    <name>A0A2G8SM95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM95"/>
    <dbReference type="OrthoDB" id="2753611at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="18048" checksum="9A230EE139937930" modified="2018-01-31" version="1">MADVPTTSGSQSSHPPVRREVPLPNPEPTLAFGFVINDQCRLRWARNLMEEYLQSGEATYTREECEDMMDGLMVSVITAMPNRVYHTHPDVPRVRWDLLPIAHKKHGFHNFVFALRDNSTVRRLHAPLIQEHIETVRKAIGLPDDQQPKWVRMPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMD8</accession>
    <name>A0A2G8SMD8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 1</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_02696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMD8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMD8"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14311">
        <property type="entry name" value="UBA_II_E2_UBC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="63"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL34909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="280" mass="31006" checksum="2239E66926750589" modified="2018-01-31" version="1">MMKGGPKTRARNAHLLARGVHDAPVPSATFSAFLLPCTHTFCIPLHSCIYTLYRCCTGGEMDARLRRVNKEIADCKNDKQSRVTIDLVDESPFHLIGSFDGPEDTPYQGGRFQVDITIPDNYPFQPVKMKFITKVYHPNISSASGAICLDILKDAWSPVLTLKSTLISLQSLLCSPEPRDPQDAEVAKHYMTSKSSFEDTARYWTMIYAGGPGKDGLKGGAKDGLRDEIAMAGLDRAHVAQFEGLGFDRAKVIDVLRRLNYRGANVANINDDRVVEELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMT6</accession>
    <name>A0A2G8SMT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_02846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMT6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMT6"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="409" mass="43508" checksum="C52F8B36C78CE917" modified="2018-01-31" version="1">MPSDDTTHTSPPSPTFWAWFLSLFSSQHTHTYEMVEKTGKKNVVIIGGGAAGGGVARELSKKLSPAQYEIILIDARPFYTHLPAMARIAVTAEESLEDKALMGFEKLFHNGNGTVKHGKVVSIAEAAPGKGGEVVLEDGERIPYAALLLATGAIWPDAIQLPQTDAATKSHLGSWRNKFEKANHVVIVGGGAVGLELAGEIKQAFPKKNVTIVHRDTQLLNSVYPDKWRKDIERRARVRNINLILGDSIEDLSSETVNGVTTANGKSIPDADLLVPAFGAKPATSFITSLGVDVVTPSGTVKVNEYLEVAGHPGVFAAGDIIDWQEQKQAAKAGAHAGVVAANITAFLQGQPPKKAYKGSPEMILIPLGKTGGSGYIGLLWGIVLGDWLTKTIKGKDLMIGMARGARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN98</accession>
    <name>A0A2G8SN98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN98"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN98"/>
    <dbReference type="OrthoDB" id="2734891at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44181" checksum="897F50F7CCD79100" modified="2018-01-31" version="1">MLTLTSPGGSWLPPNGAFLPFPGQPSSLRCLTLKRVCFLPSSPPSSLAHVALFDVYIPKADSNLFKFLSFCPNLESLVLSNIRDGPGRDLDLQPVHLPHLRRITLHRLLKHKAALYLTHLPRNRGQAVQLLEHHTSGDSWPNHCPPDAHTLCFEHCLLREDKEPTFELEAGVVAVTFLGAHRTFHVTLPIRHTIYSLYDLPVILDALMCKKSLTRVREAWIVGIHPTRPVTGVNDDDGATVPPERHRLSILIHLVIIGLGALDTLVVVFRHTLEPNLYILPNALDPSFVSRDLKTVRLVLSHGLCHSPMDLAENSPSLANLPKLNLATVCQGLASGQYAYVETLILEVGPHVVVDDAELLQLSKHVPTVRVVSIRTVPQLALPEACKESAADRAWIGGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNY2</accession>
    <name>A0A2G8SNY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNY2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNY2"/>
    <dbReference type="OrthoDB" id="2748246at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="28"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="26236" checksum="85D0C58F871A001D" modified="2018-01-31" version="1">MPPVSSASTLGVRLMGQSGKPLSPIWEDQDLSPKIRDVCALARANGYRCIWIDSCRIDKSSSSELSEAINSMYAWYKGARVCYAYLVDVPPGGDHRGTLSPLRESQWFTRGWTLQELIAPREVVLLSWDWAPIGPKYAFADLIEEIAGICVEALVHYERLDRFSVAQRLSWTARWETRRVEDQAYSLLGILDIHMPTLYGEGDRAFHRLQEEIMQRIASRTKGFVRGARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNY7</accession>
    <name>A0A2G8SNY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNY7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNY7"/>
    <dbReference type="OrthoDB" id="2163387at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="345" mass="36505" checksum="3C6007695F7BDE28" modified="2018-01-31" version="1">MATPSSSATTPSPRPHYLQSSATASTSLAMPNGLLPNDTEDRESLARKITADAHLGELALSLRARLLYANFKVKSNTASHTLHQLDSQLSAAGRHTPNGKRTANYFNEPGSPSGNPAGQSSRSGARKGSMAPPPPVTASAAQSLFSSLLAPPPAKRARTIHNPEDPPVPPPEKAVEHAHSPLRPTKTTRTPDAHGKSKSKRAAKEKASAPGSGKSKGKGKQRVTAEGSFETANSVEEREIDMEAAATLTTLLLNQQRPSISATAGSPRSIRAELCEDRTGRRHPCALVPTIASCESYAFYSYPTPFPCVVPSLPGHVPGVSASIKFDTGQQLATRGRWHPEDNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ96</accession>
    <name>A0A2G8SQ96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ96"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ96"/>
    <dbReference type="OrthoDB" id="2012566at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="24380" checksum="4CA126FDE272A8AF" modified="2018-01-31" version="1">MADQVQNPTEFRTLILDLGDVLFTWSAVTTTSIPPRLLKDLMNGPTWFEYERGRISQAECYARVGEEFSVASSDVDEALKQARESLRPNEELLALVRELKARYAGRLRVFALSNISLPDYEYVITLPTDWSIFDRVFPSALLGERKPDLAAYEKVVREADIDPATAVFVDDKLENVKAARQLGIYGIVFEKQEGVFQALRKIFGDRVQEKGGERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQE2</accession>
    <name>A0A2G8SQE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rpr2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_01622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQE2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQE2"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25444" checksum="0A5A9335726F325F" modified="2018-01-31" version="1">MGKKNKDQDPAASLSSVQNRDIIQRLNFLYQASTYVNSIAPPLDGSISPRRGPKKKKNTIRHPKDSAELSRCYVGTMRIIGQKTMVRMDPTLKRTLCKQCDTVLLPGSTASVRIRTSGSHRQVVTYTCLACRSSRRIPAPPVLDVNAAAPDSAGPSTAQAAQPSTSTSTSGTLAGALADIMDVDPPTRPAEPLQKKGKGRNRRRRAVPHVPPLFERPGHVVFRGAEQLTEYSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR87</accession>
    <name>A0A2G8SR87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Conserved oligomeric Golgi complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR87"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR87"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="1">
        <location>
            <begin position="39"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="494" mass="55637" checksum="ACFCF276208FE339" modified="2018-01-31" version="1">MQLPQAAVHRRIHAISSVLQFWGRAAVVCGALTRPRQSNTSVSQYLESLCDYLYDDLRPRILHEPRLTALCEVCTVLQALMVLDIPSLPESSSSDEVDLDELTLDLDQPRRLKGLRTLHISHLLQMVLQDAQTRLFFKAQSVIQSEIRYYVPKTEDLAYPDKLLAARKPISHTEIKEKQSISQLFQLKSLDKQETWYPTLQKTVWVLSQLKDFVKPAIFDDLAQEAINYCKQTLVSAAETLKSKNPPSSVFDGQLFLARHLLILKEMTQNLDLVHRSVDRRIDLSGVNETLASMLGRTTSLLPNALLTSLGMPRDEDLTDVRHGIDQELKQACEAVIQSGVDVVSGGVRAWVDRVRATFATDNDPSNPSGQPGLSRLESVTEPSWAGLDDIQSFIDRMQSDVERDIHRVSMNLRLYIEDERTVDVLLKHVQDQVVDDWMDFSGLLSKVHNGTMRSKAPTAEYVRVRVLRGSAENWEPQEAVVPPNSSSSSSAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRB2</accession>
    <name>A0A2G8SRB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRB2"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="185" mass="20708" checksum="09B94A8C4E91C039" modified="2018-01-31" version="1">MFEPVRGGTRGGQAEFKWSDVSQDKDRENYLGHSINAPTGRWQKNKDIHWYQRDGPQGDEERREELRKVKEAEAEALAAALGFAPGAKSGPGVSSGVGTGANAIAVPVKTDDSLDPEKEERRMRKAQKKEEKRLKKEEKRARRHREREDEPNGYEDNHIWSGWSGAPGESVEDSTATTAHGQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRL2</accession>
    <name>A0A2G8SRL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRL2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="86" mass="9542" checksum="41FE15166319317D" modified="2018-01-31" version="1">MGHAPLFMVACYARELAGLQVQITGVEMHERGGHGEGVVEEPRATRQRAERRELGEASASDSVRTCETGLKYPRRKDSGPSEWDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS31</accession>
    <name>A0A2G8SS31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_00241</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS31"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS31"/>
    <dbReference type="OrthoDB" id="3061254at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="16">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="251"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL36552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="334" mass="38205" checksum="47EDFCBCB6E9300C" modified="2018-01-31" version="1">MLKDKGIEIISSAPHIHQQNGRAERIICTLMDKSEAMRHDACIPQSWWEFSFEHAAHLHNRTPTRRLEWRTPYELLNGTKPDISHLRIFGCGAYVFLPPEVCKNKLSPKSELMIYLGVGAGNHNHKFMRLPNNVIFTAAQALFDESNYSFLLPDDGDEPRRPPTKPSTKGKGKLRLYPLYLLNLVHSTERTYQKCNTLCRRNLLRLTGQARKNRDGLRESGKYQFTKAMSMVKHDTLQTFLRTLRNGDRGSKWLRSAEHDPPVPIPPSMRTHREPTPVISSSSSDDEEEEDMGSDPIPAFVLPQPESPAPSPDRSDPDDDDDDDDDEEEEDSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS82</accession>
    <name>A0A2G8SS82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS82"/>
    <dbReference type="OrthoDB" id="549336at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="55828" checksum="B216A1CD817E39EE" modified="2018-01-31" version="1">MLPRQFTTVGLTAAVVVGSLWLLLHSLDFSPRYMQGFYPPHRDRYNDSEWYTSSLTSLPPRCRKNIVVASAFPFHFDVYMAAAKTIGDVLDSQPEDEEERGTIHLFTPDFSFGFDDIAEELGLWKHRGTRGRPEELGNFTNADRGASGIDLIVFGTCEVDLPYWHDELVAAWDSRDAEHKFKIVCIVHNVEDTRWQEHITHWARRGAIRLLPIADHVKNTFRQKFNAIADSSDAGLYTAGYQHIPIDVHAPILDIPYLPIKPVPRQLVYAVIQGTLAANRRDYLRFFNDLIASLREDAAAWGYLPLNGRTAFEPDFESRIPPFQLLLVGAGAIEIPAELAFVVTVHHDLAYKDFYTLVANADIVVPAFAPLGYFRDQASSTVALATELAVPLLVTERLRRTYGYIDDARAVVTRPAAMSEVQALKALRTGDASAFLNSDPAGVGVAMGGVKGVREAVDRMLKDGWARDPEEWMEWRQDVWDRNWMVVDRILRDMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUC8</accession>
    <name>A0A2G8SUC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type 2A phosphatase activator TIP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUC8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUC8"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33869" checksum="0F1A854A84EC38E5" modified="2018-01-31" version="1">MSAAVALPQHRLLESPNSRTIEIGTWTITASTNPISNAGQCDALQAAIGGIPLPEMTFGSNSLELEHKGSGWKYSFKTEDALKGVKNGELEDGDGGVKVGYADAWLKSRTSPLSQIPMPKTVPTKPYDWTYTTLYPGHLEPTGCKAIDWKPAERNDPNHTIPLVELTRHDPILFYAEIPLYEDELHDNGASHLLVRIRVMPTCVFILQRFTLRVDNVLFRTYDTRIYHSFASSPPLVVRETSGWEAPYGRVKSRLPKRDDLTPLTDPMWIAKILTEMPSEISQEIGAGTKWRGLGTKIDIATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLC0</accession>
    <name>A0A2G8RLC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLC0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLC0"/>
    <dbReference type="OrthoDB" id="3261476at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF18">
        <property type="entry name" value="RETROTRANSPOSON, UNCLASSIFIED-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="7077" checksum="D7AE8AABF136122E" modified="2018-01-31" version="1">MRTQSINGKNRHHVSFIDDYSGYSASYYLKHKNQAHKAFLEYKAWAENQTGEKIKKVRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM76</accession>
    <name>A0A2G8RM76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15305</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM76"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM76"/>
    <dbReference type="OrthoDB" id="636685at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="23483" checksum="DD78F1D692FC82C3" modified="2018-01-31" version="1">MSASPTSSPEPATLDEPIHMDAEPPQQDDQEQEAQTSTDHPKPKKAKASSSELLVREPGKSLLPYSRVQKILKADKDLIMVQREAVFLISRATEEFVAQIAEASQAVASREGRATVQAKDLMSCIRRAEEYVFLEEAIPFLEPKPASIKPGKAKDSKTTKSGSGNQQNPQKPQPQPTMLDHFVQSRKNDTQDSQGEVFENEDGTLSGGGPSELPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN69</accession>
    <name>A0A2G8RN69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN69"/>
    <dbReference type="OrthoDB" id="2756797at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="203" mass="22417" checksum="3D4B75FA16F9F1DA" modified="2018-01-31" version="1">MSLVPSWKPLDEQGLRDFLFMSGATEDTLESTLKAYNSVTEMTLQRGGVRVIGVKPEPGDPNVYTIRVPDSPYCLRMWAGGMDYWGQFCLDFFDIEHKAPVNLPAGYALYGGASSLPPGGAVVHALPAHMAQANVRPPQGRPLGSWERNMGITPIPDGAEKWSIPEGMPLMLRRDGHPDFMFQMPRRQAPVVFAQPQMGYPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP29</accession>
    <name>A0A2G8RP29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP29"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP29"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="540" mass="59482" checksum="9666A8C9F60E2893" modified="2018-01-31" version="1">MAFLKTHLQALEDCTAANPDLPIYKLPVYDNDDTLRAWLPVTFSQFKSDVEHFAAYLAQRLQSDGIPPRSVVGLWSNGMSYVDVLYIYAIARAGYIPQLFSLRLPNPDVIYELLAKADGKAIIYEPGLADTVANCPCPAYSAVDLRNVDIGDAPVPPMPRPLNADDIVMIFHTSGSTSGRPKLLPCTYKWLDAMVDKSARTSRPLRKDGQDVTVAMGSMCHIGQTYMFLASFQNGACTIQPRSVTFSTDELVHMIKQGGLNRLNEFPAFFATHVRRARADPKVLALLAGLDEILYSGQPMPREDEEWAYAQGLPLRNLFGSTECGAMLLSVRASGAANPPLRPIEGTAYGFFPVEYSEGEDSESGYANANDSLLELVILSSSPDCPHPSMRAADGHYHTGDLFVEVAPGAYVGRGRGDDWIKSENCLRCDTRAIEDNARETCRGLVGECVVVGNGRPSPALFVELAEGVEMDDARACREIIRRIRHFHARRYLHERIVSAKMVVVVPRGSLPRTATKGNVRRRAVEEQYKAELDAMFASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPI4</accession>
    <name>A0A2G8RPI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAM-dependent methyltransferase Erg6/SMT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPI4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPI4"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000232">
        <property type="entry name" value="Sterol 24-C-methyltransferase erg6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="4">
        <location>
            <begin position="53"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="352" mass="39652" checksum="2859189888177614" modified="2018-01-31" version="1">MAVSKTETTAHADGRVGRRIEGYTQFWQKDVSKEASQDTENRLENYVDVINGYYDGATGLYEYGWGTSFHFSRYYKGEGFYQALARHEHYLASKMNLQPGMRVLDVGCGIGGPAREIAQFTDVQIVGLNNNEFQVGRARKLTAKAGLSDRVSFTIGDFMKLSEQFGENSFDAVYAIEATVHAPSWEGVYGEIMKVLKPGGVFGVYEWCMTDKWDPSIPEHKEVAHGIEIGNGIPEMRPLAQAREAIVKVGFEIEHEEDLADRGDPIPWYYPLEGDIRKAQTLWDVFTVWRMSSSGKFVTHHGLWFIEKLGIVPKGTWEVGETLKIAADALVKSGREKLFTPMYLVVSRKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPM4</accession>
    <name>A0A2G8RPM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPM4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="216" mass="23406" checksum="094999586C70A395" modified="2018-01-31" version="1">MFDFDSKTSVRNFAFMVTLSMGSADKMGLSSSGAQTGTLPNTYGAIQGTASSLLWLRPVRPSTLPLPVCHLMVQHRTFGRLRRGEEAYKSEIVMNAPAMLVGDVEIRDMGVEEVKAASGDSKVDSSRASHQAISKLPILCANNIGGHKKPASKELRNPVDPFAAWLLRGMQRGCPPRRASISPDGRPRREPTREEGLLSGSGDGRISMPARQQGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQE8</accession>
    <name>A0A2G8RQE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQE8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQE8"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="16"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="477" mass="50848" checksum="AF50FB3A2244BA3F" modified="2018-01-31" version="1">MSPGEPQAFTAYGWIVCVWILLVSFQYGFHISSLNQIQAVLTCRVSDIPGIPSTHHALPTCIPMDDATFSVVTSVYTVGGLLGSLGANIVMDRWGRKGAVLTSSFIMAVGAGFMAVAASLSPLILGRLLTGVAAGVGLCVGPIYIAEIAPSKIKGSVGVLTQFAIVIGIMITQAMGLKLATPTTWRLVLLFSAALSLAQLLLGTMIVESPVWLSRHGSVRDKDASARRLWQSTPTLRSSDAANEDAEDPLLGANDDHDRHEAQPHAVNVPSVLLRTEFRKPLAIVCFSMLCQQLSGKSYPGNVMLSRWHLVLYYSNDILSKTIPDLGPYVSLGITIVNVFMTFAPIILIDRLGRKKLLSLSATGAVLSLVGVGIGLDSGAVTLASIAVMAFIASFAIGIGPVPFVMIPEVSPHHAVSALSSIGLSLNWIANFLVGLVFLPLRNFLANGDESKEGRVFFVFAALLAFFTFMLFGTYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQJ5</accession>
    <name>A0A2G8RQJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_13534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQJ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQJ5"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL23784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="129" mass="15313" checksum="23EE440169B75C12" modified="2018-01-31" version="1">MTIFGPLGLSLAPAIRKNRSVYAWVKPVADWYANVSGYRKVGLKYDDLLVEERPDVQRALGRLTEREAYDRQFRFRRASQASVLHDDIPKEEWIKPEEDVRYLKPHVQSVVAEDQERWKWDNIEVKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQW7</accession>
    <name>A0A2G8RQW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQW7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQW7"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="280" mass="31277" checksum="5A396EFE5A3ACD19" modified="2018-01-31" version="1">MSYRAADSGHRDIYAPLPLINHERLKLDTTTPFIPGYVKNRVTRSSDPAQAYASRVQGRQILLENPARDSRAKKEREEKRARRTAERARKAVGVVSKKESRKRGIWKLRKEEAKFELFVPLHMLWLGYMSELLSLAPQPATPSADPASAMPGTAGMHTKLVKADFHGAIVTVRQSKNPCLVGLSGIVVHETENSFKVITRKDEQKLLPKLNSIFVFAVPLYAVSASSATPPGSSADADTGDVKTILDMPHIEFELYGNHFCYRAAERAGRKFKHKETIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR05</accession>
    <name>A0A2G8RR05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR05"/>
    <dbReference type="OrthoDB" id="2753605at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31016" checksum="6C276DB260C7A390" modified="2018-01-31" version="1">MELTYDTFALVFEQCSTQSLIRCAGVCKLFRSMVSAELRRRYFTVLRWFFGTRKYDAHELLQSHRAIISGSTALAFLAWTDTWTPSDMDIYVPNSSYGQFVYDLEHRQLGWFEANLGSGNHSDYHGILTVRRYITPTGERLDVIQSSTANAAQPLLHFWTSAVVNILSPFGAVCAFPKTTLDHKALVSGISRSQKLVAARIKYEARGFQFAEVGTWRAAADSEGVLTLSNEPILVVDFLSVWSANSTRLPITRAGSRWVLVPDHTDLISGKKFFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRR5</accession>
    <name>A0A2G8RRR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA 3'-terminal phosphate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRR5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRR5"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="182"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="39987" checksum="A8C6BB969D5806D5" modified="2018-01-31" version="1">MSQTPSVLHFSGHQYLRHRLVLGILSGKPVRIDKIRSEDQNPGLRDYEVSLLRLLERVTNGTVIEISVTGTAILLKPGIIAGGNVVHDCPSSRSVGYFLEPVVMLAPFAKKPLQLTLRGITTDENDLSVDIMRTVTLPHLQLFGVSEGLELRIKKRGSPPLGGGEVQFLCPIVKQLKTLNFVDPGKIKRIRGISHAVRVNPQFSNRMIEASRSVLNRYIPDIYLYSDVYKGEESGKSPGYALSLLAESTTGAMHCSEAVSKPGVAPEDIALLASRSLLSEIRRGGCVDRQHQVLVLLMMVLGSEDVGRCRMGIPTTRTIQFLRDAKEAFGTAFKIVPADPEDSATDDFLYSCYGVGYVNANRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS63</accession>
    <name>A0A2G8RS63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DFDF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_14086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS63"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS63"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="217"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="37718" checksum="7216C3D6137BB4FA" modified="2018-01-31" version="1">MAALSFIGKPISLISHSDVRYRGILAGIDPVASTIQLSNVYSMGTESRRPPNEYIPPVTEPYTYIIFRASEVKDLAVDEPVNQRRDVREDPAVIGASAPQVAPNYPSYGSPSYPQQAPVGVSPQPGQAQVAARQQQQFANRPQGQPSGSQPVQALNGQAQANGVAPPRAAAARNPSVNSVTASMETIERAIGDLRVSNGAGQQQRGGRRGGRQGPEIKAGDLRVPATDFDFESSNARFDKAALAPSPRGTPKNEGTETPEGEPKEDEKDAAYNPKKSFFDTLSSGSNGPAGDNRGRGGRRGGGRNRREEERERNVATFGEPGGVGLMGPGAYVGGWGGYGRRGGGRGRRGGAVAGGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSU1</accession>
    <name>A0A2G8RSU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_12438</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSU1"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056236">
        <property type="entry name" value="HMA_PCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24534">
        <property type="entry name" value="HMA_PCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="640"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="951"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="domain" description="PCA1 HMA heavy metal-associated" evidence="10">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="9">
        <location>
            <begin position="489"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL24554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1008" mass="105197" checksum="420A1F70E5336863" modified="2018-01-31" version="1">MADDCACCDDDSCKDSIQQDEPSAASSQPANVNPVKVCADSGLRKRTSAKSSSSPRVPTEACGEHRNIVRSRYNDTLAAFGCVCKALLARGVKSCCTPAASGKGVARPASSKNSARLSIPKPTSAQSSRAPSIDSCCGKSDCGGEASGVRKVPCGRRKDGSSRSCASLVFDCDDSCCGGGSDKKNDDAAIDLAERGAGAYNEHVVLAIKGMTCTGCENKLIRTLCAIPTIGNPKASLVLCRAEFDFDNGATDLASLIQLIETRTGFTAEAQVVREGSIHVLLLTVPGRPHQERLIAAERADGVKDVVHEGKDLVVVSYDPTVIGARDILTTYSAFSPVLAPEPPDPAILAGVKHIRSLSVRTALSAALTIPVLVMAWAPLPPRPHAYSIASLVLATIVQVAITGPFYIASFKSLVFSRLVETDPLIVLSTTAAYVYSVVAFAFETIGRPLATGQFFETSTLLVTLIMVGRVISAVARQRAIEAISIRSLQEKTARVVFPDRHEEVLDARLLHLNDAFAVLPDSAIITDGEVVSGTSTVDESMMTGESRPVEKGPGDTVVAGTLNGPSTLVIRATRLPGDNTISEIAGMVEGARFSRARVQDTADWVCGWFVPVVLGLAIITFAVWMGIGVGVRHQSGGEAVVVALTYAISVLAISCPCAIGLAVPMVILIAGGVGAKLGLVFKAATTIEQARNVTHVVLDKTGTVTLGKLSVVNRFVEDGLGFEPLAVIAELVASSRHPVARAVAADLNTPLSGEPTIEEVEIVTGKGVQGSFRGKLLRGGSAQWVGMQTHPAVQPMLAQGLTTFCVIHGMRLVAAFGLSDTLRPEAQAVLQALAARNIRVSLLSGDHPTAVSSVAKALGIPPERVRASCLPADKQAYVKELTAQGETVLFCGDGTNDAVALARAAIGVHLHTGDGAGVAASSAADVVLTHPSLSGLLTLLALSDAVTRRIAANFVWSAVYNLFAILLAAGAFVRARVPPAYAGLGDVVSVLPVVLVALQLKWFKASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU19</accession>
    <name>A0A2G8RU19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU19"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU19"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="119" mass="13835" checksum="A2BAE25C5641B097" modified="2018-01-31" version="1">MAAQQSQSIQTLLEAEKEAAKVVQQARQYRVQRLKDARSEAAKEIEEYKKSKEQEFKAFEQSHAGNTQTVQAQIDKETEGKQEEIREAYDTHKDQVVKKLLDRVVLVKPELHRNLKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU99</accession>
    <name>A0A2G8RU99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_12943</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU99"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU99"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="82"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL25054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="588" mass="66049" checksum="69CEC6CB1A8FA8FA" modified="2018-01-31" version="1">MEAFEDDNPFESEPERFQSDSSSSRVDVSGVSSPDLPGQHARLSSPPTSPSRRNTFPSPGSHRQPQTYKSDFCCGRDQWLHSGEEAEILITDALKTSVNSSSPYITYIIRAGNAEAHHRYSEFESLRNNLVKLYPTLIIPPIPSKQTIGDYAVKQAKAKEDAAMIARRKRMLQTFLNRIARHPILSNEHIFHRFLDGEVSWTEVLNSPPISLLPKNILKAPSHSPTDQNASPAYAALPNPSAAHPLRRPDQRFLDSEVFTNKFAAHLSGPMEKVTRRTMRRWSDYAQDHAELGATLNGFSLNEIGQLSTAVEKTGQAVDATYMSTTTLLQEFEQNWAEPLHEYGQFASIIKKLLQYRHQKHVQYEMTQEGLETKREQLEDLEKSEREARRLEEALSQGHSSTAREPPSQIGEEGEGEVEQPATNENEARRQEASVHLPPHPGPSPVKRRAPGMGFLSALSYTLHGMMDVDPETARRNSITKTREGISQLEDALHLSAQDLKYSSSTIQADLDRFQRQKVADLREMAISMARSHRDWCKKNLEAWEEAKTEIAKIPDHPNRQADEVHGTNGTAVQGRRDSVATVNGQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUT7</accession>
    <name>A0A2G8RUT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13133</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUT7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUT7"/>
    <dbReference type="OrthoDB" id="299997at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051266">
        <property type="entry name" value="CLCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579">
        <property type="entry name" value="CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10579:SF43">
        <property type="entry name" value="ZINC FINGER (C3HC4-TYPE RING FINGER) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="127"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="687"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1200" mass="130648" checksum="E88DFBBD2BC4F841" modified="2018-01-31" version="1">MRSEFSPSWIPKNSSSSPARHQSHLDQSNSHHHLLPPPSSPLLTPRPPGSSKANSFAASVRSVFQRSPQRVTSAASLRSAYSANSSVKPPSYTSQADSTSLHPYAAMVAAPLPVVSSHDASDEEEECPVCLEPLSSSFRLPGEKPHIVPECGHALHEACFTAVYGPPPGPSRAGGVVRKSNLGVCGVCRRPMKVGDGDTGKSNKLAALTGMGDPTAANLFPGRDTPSSMRQYQQRSPGATVQKPFDPTEDDPIDHKTATTSSRDHSHYVVAPSIHVQSEFPSITRSSDASQPLTCLVVVELPGKRQNTHVPGSVMPSSESYTPHQKNGSLARDGSSHSVHSGPRPGEYGMSPRSQHISVDQQSQTGSNHHMSPSPSREPGTSPLEREIIQQDEDSPFNSITEDLRNRIIDWKGHPLSGLGALQMYDLLSVRRDALVREFFVYLFKEAIICVVEEKKRTLGRLLSSAGAASAFGDGTGSGSINGGNSQRGVLRLKGRIYIRHIRQVTDTSVQGELSLTIDMEDERLDSFILIFKDRSSLETWKQHIQVLVAVYQQQTVQAQQPQPDFGRTPDLEEFGGSMKAARMLTDEFGGSQKAMRMLSGSTTGTTVSTADSLLNGSARSTVSSNTSYGSASLGPARLGLQQKLSTLDEDEEMSRYSSPAPQPLVAPHMSTGPSNSLAPLAHPPMDLILVISVPGPSATPSTAALKVRVIKTSLDFILHALSSKDRLSLVTFEVGIGGRVRRTPFLSVGKPQSRQRLVKFVEDIGRREDFDDEFVVRGSQEEKTDVVTAVNNGLDVVLQRKSRNPVSGFVLVSDSSETTRRAQMDLVLARAEAANVPIHSFGYGRSHDPASLWLMSNHTSGTYTFVKDWYDLRDCLAGCIGGMMSIGLANMKLHLKIVDGNRFRIRKISGGPLAILSSDGRDVDVEVGELRYGERKEMLVELELDNSDVAQSTAAALHGHSSRTLNATDVFNQRMGLDAMSIGDFPDLAEGMMDRMIDEVPVFEVDGSFFDPNAAKNVSRLAHPVLLTVTLLPNTGSRPRTPAPSGSDPVIVRRRMELLASDMITRMLVLVSRRNVPQAQKLMSETRRILHTVLQNVTATLPPPTREGGPATRNRKELLTMSAVRAIQSIMQDMQILAEALDDQADTFALDQRNFGAQQAKVLRDQKSWSGRSAIERLFWTIDSSIELVSRSTDWVARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUX9</accession>
    <name>A0A2G8RUX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13215</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUX9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUX9"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="10">
        <location>
            <begin position="127"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL25326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="464" mass="48623" checksum="06E6B03D6B9CFCC3" modified="2018-01-31" version="1">MDSISPKLSVKAVTDWLAGHGLSVESRSYSGETLTVRVPAACANAILAANFTAYMHDATNTTMIRTLSYSLPAYLYDHVSFVYPTTQFDAPVRLGAALELSLRQSRPRAPSRRADSASEVPASCASSITPRCLQALYGIPTMPATSSGNSLYVSGLGGTSANPNDLQTFLEQFRPDIKNGTYTSLSVAGSSDTGIPTNEGNCDTQYTVGLATNVSVTYAIAGSMSNGVTFGDLLNTVVYLLELDEPPLVVTTSYVFDEPVDSESIQVARTLCNYYAQLGLLGTSVIFASGDNGAVGGGSNQNNGCQSPAPFVPSFPSTCPFVTSVGSTQGVNPEVAASFSSGGFSNIFSRPSYQDTAVNAFLHRQGNLNAGLFNISGRAYPDVATQGMNFNIRVGGLTYNDFNGTSASSPTFASIIDRLLAAGRSPLGFLNPLLYSNATVAFNDITAGDNRDSMCGAGFNAEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV07</accession>
    <name>A0A2G8RV07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV07"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV07"/>
    <dbReference type="OrthoDB" id="2767786at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="76"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="303" mass="34360" checksum="99AC6A0F45FF43EF" modified="2018-01-31" version="1">MGDLLEQLDSLRALGHSSANLASGSNNQPHVHAPPPLDGVRQDILKRFDALETKQRQILLEWPELKSAWNRSLVITQLPNEILFRIFVYVSEQPKPKDSRKYYVQNNEDFLELGLVKTELVKLTLVCRRWRDMALATPSLWRTIDVGKTSDWMNLALTRSGNATIDVSFPSGFSEEHATLLTPHCYRLRSLRLQSYSPCVIRIIRNILPALETLEISSNWHVGLNAEDCTDLGLARERFPNIRALQLIQNIIPGDPLFYARLRKLSLKACYFKETVDLDQFPGRQTRSGGIALVTILALSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVL8</accession>
    <name>A0A2G8RVL8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxC5 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000047">
        <property type="protein sequence ID" value="PIL25547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVL8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVL8"/>
    <dbReference type="OrthoDB" id="3055037at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="1">
        <location>
            <begin position="114"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="169" mass="19574" checksum="4DB1B1BC9D89A3FE" modified="2018-01-31" version="1">MLALSTILVRLAKHEDLLEKLSYQTLDHFFKTMFRYMPRVVTTAPRRTRGVPPIDAALRNLLALTLQLSYEDVDKLWGITGDLLVKEFEALHKLGKPPGLDDRLNKVAPQFGLGCNTTYRPNYYVQNADSISSVRHYYEEVPNFLEVTQHSYVEEELVQLFRHQMAFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW13</accession>
    <name>A0A2G8RW13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_11451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW13"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW13"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="878"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL25701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1050" mass="114225" checksum="C45A6EEA168A496D" modified="2018-01-31" version="1">MADVAPPSLLMPPALRGGLRIILGFKVSLTMPATSYHVPNPLHPQIESCLAGSLSQANPYASPSQTWQQHVPAPSQDEWTPMPVYQSSSCTAQPMAAPYVDNSAFVPEAKDGGSNHHPPRDAPEHAPGYIRVPAHCSLDQDAESTPDRKSSGRSRGAGASVKPGRKRARAARQTTAKRTGACARCRRLKMKCTFAKPEDEVCSRCAAGAYELECVFPGRKPRAPAMRVVLRQQIRDTDAMIDSLLSRVNPGPTMATPLTLVPARLPLSSEERTSIEYRSILTYLERATQRGGQRFDISALEDIPSEDDSDADSDMENVASAASPVRGSSAERAVQPVDSILEVMAPVGIMATAALQSSRAAASAVPDDSSSDSGHSHESKGVASENYFLPGPQTNLQLRRLIVERQAAPDILLSGLVTPEDVTALFEIHYKCINPILPILDENIHSPASVLARCPFLFTVICTVASRYYKEKPHIYGMAIHFAKAAAANAVIDGWKTVEMCQAFALWSVYNPPARRWEEDRAWCYTGIAFRLTRFVFLSGFSSLSLCRDMLGAGGRLATELNLSRIPEPFVDERQERESHNRTRMWLMCFVIDHCLSIHSGKAWMVQEDATIRNVASWLHNFKYHNQCDRYLASLAELLTIVSRFVAMVNPAFRTSSVASVDNIDFATLYKDYDDELLAWKAVIDERHRGEKKSSDPAVVMRITLIYCVFHYCRLVICCYGMQTMSKNKAIKPDELIAGCLQAATSLVKLMVEDFVPSGFVPYSPELVFTLSAFATAVLFKCLRPEYNAYLDIQQEERIIELVQRLFTVWTSDKLSSLDECHNTQLYAKFLKQLMEPHVARLTMKKRAASVSDRNAAPHALPAAAQTSSAHEVIISLKSQTPAGREGRSNAAPSSVMREHPLVSHTAYSGSSGSAARYPVFPHHVSTAAAAGTSSQSGSMEHLYATDVDITKEASHLAAASGTAVHSDVNAENVSWEQLMAVGSSLGGGFGDALGGMMGGGGPTSTAGSGPQGNGAIDWNGMLGDEYFTAMTGLGEGTWFLTHTASHGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWB4</accession>
    <name>A0A2G8RWB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWB4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWB4"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="15"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="381" mass="41972" checksum="20220A86CA5AFE23" modified="2018-01-31" version="1">MGESSETSTDAQLRKLFQPIKVGDVTLAHRVVFAPMTRLRANTRGVHGDLAVEYYAQRASVPGSLLISEATYVSRQAEGRSPNAPGVWNEEQIAGWKRVVDAVHAKGSYIYMQLWALGRAARLGYIRERDPDYAYVAASDVPLAGRDEVPRPLTVEEIKEYVAAFAQAAWNAVFGAGFDGVEIHGANGYLVDQFTQDVSNTRTDEYGGSVENRCRFALEVVGAVSAAIGESKTAIRLSPWSEFQDMRMADPVPTFTHLVSRLAKDHTNLAYLHVIEPGYSGNVNTEMKTGESNAFIREIWLPRPLVSAGGYIRESALRVAEETGQLIAFGRPYISNPDLPLRLRKDILLAEWEQDTFYTPGESRGYTDYPFAGGGGGLSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWC6</accession>
    <name>A0A2G8RWC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWC6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWC6"/>
    <dbReference type="OrthoDB" id="2757965at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="645" mass="68204" checksum="7F2605448CA1EF29" modified="2018-01-31" version="1">MSNANTNLPLDSGSNTNPTDTTSTSPTDPNAGIAADPNVSAVGQQSATLQLSMAPATSTQPLANPDSSLGSGSSSGTHVGGFVNQSASYRNAIIIASAVSGTIGLILVSFVIWMVYRRRNRRKNGGESTSGGATRPASDSSWVGPRLNPGDSFNDGKLEAGDRGSKADSVESDTTLHGSALTHKKSSSFGTSRTFSPRPSLDKLKITTVPLVSQGPRMAIIPGSNRPSLEQLASQNLLTPLSPRVRRGPALRVESSGNFNSGIVVEQANPSPDIPLVTPVDAWRSPITDVNGNLFTLMPPPARRDSMASLSRQSSRASSRNSPVVDNEATEDTTPRKKAVFFANAKKRRHSRADSIDPFRKSAVSMKVRRKSVRASRTDVLASRGASYSSGGVVRRKSSRSSRASRAEPGSVPSTPGGRRRSRAPSVMSSRSQATVNEPRIFSRPLAPSIRGLPTDPRPPSSLSARRFESASEPFTFPSTSISTPRTAAPPVSRPSTPRTPRTPGGHARRPKASVPRTPTSLEDAHWRAVPLPEPPATATATGYPVTPRPLPIPATPQSASAIALGSRPRTPQSAIVVPPPSRPRTPQTAAVLSRPRTPQSSSNPTQTPPKTPRTARAELRLSQLSRTLSEVSRESGYSNMGKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWQ4</accession>
    <name>A0A2G8RWQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWQ4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="83" mass="9419" checksum="76AED82ABEA704BF" modified="2018-01-31" version="1">MVAYVPPEPFNLDVACAILLQFAMFITAYFVRFIRKLLCYRDEPAPGLPHWPARSTKPTHSTSPSLSIASQTSRTMMMTLWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX25</accession>
    <name>A0A2G8RX25_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHRD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX25"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX25"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013607404" description="CHRD domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="40086" checksum="266D0956A55916F4" modified="2018-01-31" version="1">MYAKAIIFALLSLSLSASAVPAKNKSNKAASSVAASADTCAATAKTVTVTQTVAAAASTGVLAANPGAKGTGKTGTGKTGTGANANKGGNNAGTGNAAAATTTSAAAAATTTAAATTGKTTGKGGNTGNNAASGASANAQTSLTLDPSNVFTAFASDGNANATAGQEPSITSTNNFINFCLEFPGAQKTNGQQVLAGSCNQTPMGLIAAQAKMPSSKFVFPANGGSITANTDFTIQMAINNLETGHFTNPTTTFHMAPQVVNDAGLIKGHSHVVIEQLSSLTQTTVTDPTKFAFFKGLNSVAANGILTADVTGGLPAGFYRLASINSAANHQPALVAVAQRGALDDMVYFTVSAGGATTGKGGNNAAAGTAATSSVAATSSAAAAATSAATTKTGTGRGKGAGRAAGKNRAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXZ4</accession>
    <name>A0A2G8RXZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12113</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXZ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXZ4"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="474" mass="52611" checksum="69568D6F6A5CAC88" modified="2018-01-31" version="1">MEYYSNNYAHHDHYQSHSVTLPERAGQPLPPPEMEKPKVSSLARRIHGWSWQAFPIGMGTGAVYVTLSGLKEHSTTLTNVETFFFFLNMALFLLNVTTLAIQLILYPKQSLRLIKDPVKGIFVPLVVLSFATIIIGTIKYAVPTGHVHPGFIYSLFWVYVVFAVLVCFSMLMVWFNNPHDLTTFTPAWAFLIFPMMLVGVIAFNVLDVVPASEERAIGVLLTGYVFQGLGFFMTFFYICIYIIRIMTTGFLDGHQANGAFVAVGPPGFTALALIKLGQNAKEILPLHGLVSESAGEIWYAASVMSGLMLFGLAVFLFFFGLLPYWFKVHKHLHEILGCWALTFPNVGWISTVRVLGDIFGLHGFFTWHLVMTILMCAVWLILFCLTLWAFVKGKIFMAKPEDVIHDSLDRKSLASPSPSSPPSSARPSFAIVHAHAPMAMSPQDDGQGARDKEARGMGMGMGIGEGARMGQEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY00</accession>
    <name>A0A2G8RY00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_12150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY00"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY00"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="566"/>
            <end position="567"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL26393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="634" mass="68484" checksum="9B550F9FF3CB8BC9" modified="2018-01-31" version="1">MGQVNPRPVPSSPRFIAVAGRLPSGEPEEQYTYDYIIVGGGTAGCVLASRLSENPAMKVLVVEGGKDFYSALPTKIPFSFHNIFGTDLDWDTQTTPQGGLGNRQTYLARGKVLGGTSSTNALIYHRCSPSDFDQWVELGANGWSYKDLDPFVLKHIYPEVPLTSSLIIRRYFLKAEKFHPSPKHPGVNPADHGTSGPWETGFPSETAPINDYVIKACQELGMQNIYDINAGRGSLGVTQLVGTLDSDGQRSSTATAYLTNDVLSRPNLTYVVDTLIQRLVFDTSPGQAPRVVGVEMTMSPDVQIYSCWARGEVILCAGAVGTPQLLMLSGVGPAGELEKLDISVVKDMPAVGRHVIDHVSSGPIRFHTAPGLTYDFLNNCFWGSLASLQWRLFGTGPLSSMVYSSTAFVKSTDPRLPYYTDGRSGAPIDDHSSGPDAPDLELLWAPHTVFTEGADVSSTSAGGVTFEAIALKPESRGRITLKSSDPSDPPNIDPQYLSTENDMNVLVRGVRLILKLAHTDPIASKLHLKPREIDASNPWWPGAADPKKVTDDEIRGMLRHRAKSAWHPVSSARMGRSAEDSVVDANLRVHGIDGLRCVDASVFPTQVSGHPCAVVVAMAEKAADMIKESAASRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYC6</accession>
    <name>A0A2G8RYC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYC6"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="31410" checksum="277690C7AC43943D" modified="2018-01-31" version="1">MFSSSSPNSDEMIDGCPVVHVSDSPEDLARLLRVLLPAAHRRFYREDAWTDYSFEEVYAVIRLAHKYNIEDVQKQALFALREYTFNDDFKKWREVRNERIPVDGPCAIGAVNLARLLDIPEMLLIALYKCLSLCTGILDGWKRSDGSIEYLSQDDVKRCIAATSELSRSSSILAYNIFRPEPCMECKQRSRCEESLRQALAEFLDLYAGDISDGSGIMVPWEGAFDEFGGCGVCEACWEEVKYREVSGREDVWDRFPKIFDVKTERWGSSVSDLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYM4</accession>
    <name>A0A2G8RYM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYM4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="83" mass="9212" checksum="B08CD5F210C38B5C" modified="2018-01-31" version="1">MRESSGADDSDSNLVKVQPALTCGAWMTISKLWRVLSRTLKRGGSVDKVVLMRKYCDVCDRVYETVGADEIGDGELEEGTSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYP6</accession>
    <name>A0A2G8RYP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_11301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000044">
        <property type="protein sequence ID" value="PIL26607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RYP6"/>
    <dbReference type="OrthoDB" id="2734749at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="7">
        <location>
            <begin position="706"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="852"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL26607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1369" mass="150657" checksum="A00C66FA837AEF55" modified="2018-01-31" version="1">MEEAQIAAATAESLEHTGSSAADSTVPAVDVFLADVASGGALPIAGEDSHPIRILWCIINEADVAECILDGGSQIASISEECCSRLKLPIDPLVTMNVRSANGSLDGAIGLARDVPVRLTPKIVVFLQLFVIRNAAYDVLLGRPFEVLLKAHTENFSPNLQFLTSAHDGSNRGFSDLEDLLEDGDATAFVFEYDAHEDKASAVAYSKLPDLDSSSVTLAYLLSCDGFGLDTSTQEKLTQSHSVDVFLSSLESPAPEFSSPDRSSSSKTSKPTKQSPPSSPSRSSIAIPEPDRAALVDSFLATKKKYKPVALKTRPLLADLPEKFRIERKIIGDPLTDMPPLNPNPPSEFAPGSRYTAERRAELHARHAHFLWPAELDLMDDMIKNQENAFAWTDAERGSFRRDFFPPVEIPTVPHKPWVLRNIPIPPGLYDEICDQIRKKIASGVYEPSNSCYRSRWFAVAKKDGRVRLVHSLEPLNAVTIQHSGVPPIPEYIVEQFAARPCVGSFDLFVGYDEREIAESSRDFTTFQTPFGAHRLTTLPMGWTNSVPIFHDDVTYILRDEIPAKAAVYVDDVMTKGPDSDYRLPDGSYETIPENPGIRRFVWEHLLVANRIIRRIAHAGGTFSGPKAWPCIDERVLVGSRCTPIGRLPERERVDAIRNWRPCTTLSEVRAFLGTVGVARIFIRDFAKRANALTMLTRKDVLFEFGPAQLAAFDDLKTALLDCPALRPLRYDSDAPIILGVDTSFIAVGYLLCQQDEEDPKIRYYNRFGSITLNARKSRFSQPKLELYGLFRALSALKLRLLSIRNLIVETDAGYIKGMLANPDLQPSASMNRWIMGILTFHFELVHVPGKKHAPDGLSRRPPQPGDKPEPPPDEFEDWLENLYSFVHITQPHTATYLPLRLPPSPDTVDMFALGLVPQARPPDIEPPRIPTSRVPRTRAALMLSCRAFATSSTTRSDRLVSTNDNGSLSTNTQPFSCSIRPASCGDVRKAARIGWLSQRNDVLLSSSKCTIAPAIAVCSQLARSFASLVSFADEFCWLGSASPCSSDSSELDPSSTSDSLDGSELAFASTAAVSTTSAVSAIGPLSFAGSSIGSPPAWDSTAGAAAAISSVFGVERLFQELLNEVSLVLFEPTKDALEDRDSRANVADFAADRADLATTSLRDSLHAEVVRRDLENGVPWVAACTYLADKYHLHHIRVSGYNSQANGIVERPHFNVRDALFKATEGDGAHWHSSVHTVLWADRTSVRRRLGCSPFFAVTGSHPILPLDFKEATYLVGPPEGILTTEELIALRATALQKRADDVDRLRSAVYAQRLQEAEDFESRNRATTRDFDAQPGSLVLIRNTAIEKSLNRKMRARYLGPYLVVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ90</accession>
    <name>A0A2G8RZ90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11103</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ90"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ90"/>
    <dbReference type="OrthoDB" id="2792843at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL26839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="58930" checksum="E5D4C7B43B6E21F2" modified="2018-01-31" version="1">MNCYLDTKDVMSTSNLWCHAQKCWGKDVMEASLKVMNREEVREDIVKSILMTGTITTHFERKQGLITYRNQPHTHTETHAEIVKWVCKSVYPFTIMKDPGFQMLMKTGPPNYYILSPSTVARDVKAIFARTCTRIANVLQNFESKLNFATDAWMTPNHRVLVAVMVHFKWQGKGMCLPLDVVEVPVSHMGEELVSAFADMLYKFGIQKKAYGVTCDNATNNDTMIDMLADKIPGFNGQCAHVRCFLHVLNLITKALLKQFDARPKSKDKDPTDANQELEELLEGLNGYYAAFAGAAETDSDDDNPDDEVDPMGEMSEAQKAAFEAGVHPVKLILAKIQNFSFKVINSTTKLFPTWRTACTAHGLSERILPWDAVVNEMCAVKVHGLRQYEMSRREWRVARQLRAVLKHFKQATLFFSEGTPHLAKVIPAMDHLDKFLTSSARSRKLDHTIHVTCELAKTMLNTYYLHTDMSKTYQIAMVMHPRYKTNYFQQLKWPEEWQELALQLVKQEWCEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZD2</accession>
    <name>A0A2G8RZD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZD2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZD2"/>
    <dbReference type="OrthoDB" id="3256413at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="566" mass="62603" checksum="0AA953A6D44FC688" modified="2018-01-31" version="1">MTRLVSLPAELIAAILNELDFRDLLRCREVCSKFKTIIDDDLRTEYKVELAVSGMQDGLSSPLTLVERLSILRARRKAWNEFAWTAKEDVPMRQGYAWELSGNVLAQTEGERTLHFKQILSAIRGIEGTEWTIPDVGCRITGFGMDPAQDLLVVIEHFWDQNSELMYRIHLKALSTGAPHPAGPPEGMLTPQSKTRSFSCSIKISGDHLGILIACTDSKELLVWDWKLGTLQLHLTGREIRSWAFLTSRLLLVAKAHSQYNEQTGCTVYIPQLAIIDLERHAPSASASPGSVSLCDTSTVCTFHFPPLAHDVVALDMVMQSDPRPTDSENVSPNSLRVPFSLSDDPEHRLFLVSLWIIRGLMEEVVLRALVPASTFLRVLSSSTLGPPVTPENSAAQTLRDFTWAEWGERGARFFVTSGNGSPASSEACYVYGTVFATTQVDSDPDTDAPDGNGMERMSVTVRDFNQLALRRSAPSRATESKSKPGPAEEQNVRVVTDATVLTGAAGVFKEEVTTSLPYTERVLVLSEPEEGQDDTSWDAAIPTEDALVLATSMWNERFRCRIMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZI7</accession>
    <name>A0A2G8RZI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZI7"/>
    <dbReference type="OrthoDB" id="3271155at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="556"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1053" mass="117414" checksum="126AC6ED37659CEF" modified="2018-01-31" version="1">MLPRDGTVSSGQVIIIWNSSDEVIETIIIKPAIGGMTTPAEPPQPYPSMPELGDMLLAALKAHEMLWSRGVLHRNITFESVMALAVARHNDDPEVLEELYRSGDLCGQEGVDRTQLSSALEDHDVFADNIVRPRPDNTQVFMASDILQRIYHGQPYVHTVTVSHDLESFDWVALYAIYQHALQTLHACSAHPLHEPLRREPPHPSTYLVDRRSGVERVPAIFRGIRALMTYAATVARSERLKAFLVGVWGVDRAEDELPRAASAAQSPLAQGVQGHPNSASVVHDIGMILDAKWLEEDSDSDSDSEESDAEGVDKMDGDSAAEAEPESELDAPVRNMAYTHEDLAKKLGIFVGRTADTRLENTAEFMEFLDDPFARFSIQDDSPTESQPHFGEVLTQARVFYDDRGEVLGRLLSDHFTHFSGDPTLVDEIRHVVEAERKADLEEIRDVAQKAVEARENDEPSLETPILSAKAANRNPEEALFKPLTRIIDTIDRALSARCGAPDFAVVDRPRPLNGGALLKRPTKPVEARHLVSYMVVKNCIFDSPSLPLGKVQGNTTLSEAIEHARSLLACLPFQLYVYGIIVCGSAFWLTWTDRAGVVLSPQYSLLDDAGLRTFVRIVLSLTWELSPSELGQDPNTEYAQGHKSLNRDCYPALLVKMHMGAPGNKLGSWTTWGDPVSLPCALFGRGTSVWRIWADDRGHPAILKVAWTPVNRPSELDIYRRMKEMIEDAQMTIPGMVKLDSIAGGDVHFMLVKGTHPAEVLMTVSALRPQNTVPRNMVDMRLQRVILTDLGKPLWKYRSPEELVRAMRMALVETDADIEKTEGFLTDFEFATLPPSDSDSETEVPQTVAPYESGDMDGSMVFMASTLLQSIKDTKPEPGETVAVPRTKEHDIESFGWLFVFAVYKHALEDAAALVMMPRKHSKGLKKEFEQIFPVARGSLLGRSAESVLRARLSMLSPTGYEHIVAYIENHVRDDHPEHFASLFRLIWNKFLAGHLPTLRESTEDNLIMKYVLDQLDVARHYVQPPPPPPLTHDAVLALFDVYLKFIGKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZQ4</accession>
    <name>A0A2G8RZQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZQ4"/>
    <dbReference type="OrthoDB" id="2755417at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="679" mass="76129" checksum="C17E96C31423A8C2" modified="2018-01-31" version="1">MQDGPRKSGESTSDLLHLGDLSLSQDAMFCQQHILDAVGRADQRFLAGEDSVALSQLGPGEVQEWCLSRITEYHNQNRLLRERYGAVARNAISKNKSHIRAIRTAYNDAAPIHRYFPPEVLIEVFSHVHPATLMPRPRVPVLGVCRYWRRLLLHTPRFWANLLSLPSWKSWNTKYHDHVGRFGAAMALSAPQRLTISIPYCFAFIADILASHAARLSSLRVGRTLYDVASVAQVLEQDMPLLTHLAILYQPCFGKVPTFTLNLSSYPKLRILEFEGAHFYTPGAPCTSLRHLKLKHCTIQPPPSDSTLRSLCAVHNALRLFPNLETLSLVHSLSEDDPYGYLRPLPELTETIHLPCLRHLELEDIPPSISLFLSHLMFPSTTALVLEPTDILPWSRRPLSSPFFPGINPSPSDPSAERNAELNLCLYLRGARDDEKVARWETRGDGVRPMRVTLSTRSSAYLRHNDDDTVALVTYFSREIVAVLFPRPVPATALGVTSLTVQRFTYFPRSAWEQLLRELPALRRLECASGGTADTLVKILGNHSEPPDEGTGFLCTRLAELALGWYIPYCTSELGQPEDRGEWEGLLPLQDNNSAERVDSESPLAAALLSHFCETLRRCLAARAGHCEPIRKLSVSLPREHDYPMSGVVEEWQVTLVEQRLRCALGHLVPEIVVAAEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZT0</accession>
    <name>A0A2G8RZT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZT0"/>
    <dbReference type="OrthoDB" id="2801804at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="880" mass="98438" checksum="AC0F893A2A9CDC26" modified="2018-01-31" version="1">MALGSNVDLEETPRSLHKAGSAAAGSVGYVDLTQYRAKCAEDMEGRSVLADCIWEFLDELLPYPAGDDLPSRPKPDPSDVDQTGQKIDGAIFHSNEAPTDGRPWWFLQIIPVEFKSRKHGNCGDPYTDIGDGDSPDSDADTRREARGQVTTYAERIYYMQHRWGLFMLLIIGRRFRILFWDRGGTIVTKSIDYYEEPDALCEFLWRVSDHLPDEKLGIDPTATRLQPDDFDSIRMDLASLYVRAEFAETIKDDSYPRYTLRVQDEKGSRSFLVGNLKPVYAASGMGGRGTRGYIAYEQATKRFFWLKDAWRAAYEHVSSEGDILQQLRDVAGITNVPTLVCHGDVGHQATVTADWWERKHPKVTADSTPAASRPTPARDSVISRMKPKHDGKTSRKRADTVERDDSNCGANNADQSTPPPTFRADCPIRRLVHYRMVVAEVCMKLDKFTNGRQLVSVVLDCLKTHKLAATHPIVGVLHRDITGNNILIYPKVVTQEDGSRRLEWKGILSDWEISKPVAADSRPRQPERTGTWQFVSVNLLSNELARVSIPDELESMFHVLVYYALRYLQSNLSDHQVAKLLDEFFDCFTDEDGAISCGNLKASTLRTHGELKVIQGRFGSVRVLFRSPMDHIITTLLQWFKARYAVLDYNVWVEENGGLLLGSLPGASEMGHTAETPPPPSRNAVSRGGDLVDDEDGDVNDDVLYQDLVAKDPPTDDEIALEKRIQGHDDMITFLTPLALPSSRWQSRDKAPSDRVPANYVSPYPIMPNGTWNPDRFLQIETAKQPASVGVFANLMTFCKLSRTIEASSPAAGIRSCIGWRFSVIEMQAFLGELLETFQFDLPKEKVEIQCAPAGVGMVPIVRGKPELGAALPLRISLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0M1</accession>
    <name>A0A2G8S0M1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0M1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0M1"/>
    <dbReference type="OrthoDB" id="3237250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1037" mass="116807" checksum="85C6D89B5B26C810" modified="2018-01-31" version="1">MPLSYFFYKGEVYTSPNCTLFPSSGPPSATEDHPSWSYVSPSTWGRPMWAKRDYLELAFYPTSLNLEGSLLRHLRFYRRSNVPLEERLDSGVLKYRVAHAMQLYDLEAILVEVRNILQGLVEVLVSLDKQAFRGPSSENYMSWSKDRQAVQQRGFFVRRKFLYHIATISFYIAIISYCTGDEHRWYSLLLEKGTPAPLADKLEATILGDFRNVPRAGAFVLPDHSTAEWNFYFRVLVSANVPIYLAWGPLHSLLPGIPQRFPQCFQKFYPSESSLADLRGGQDLYLVRNRPEPPPLTLGFNIYQDQDRAPSSPPLPSSKHEPPMVTGGADTDKLSHHPISQQGNEMLDSRYYWRGRLLLPGEKPPSAPKFLPTDTPGSFFSRCTAARDHYVSTVESQSQKAARRTREKAAFNYQLSRDGRDALYEWNFNYYTMRWERNLVPRMDQQGVWESYSPSCKRYDPVHGEWDVAEFLDYGGNEISTQEEYRMLLDDEGSHSYDIAQWERRPSNPFFHEEDHHLAPQPPDNDPPQTATPSDDPPQTATPSDDPPQTATPSDDPPQTATPSDDPPQTATPSELATESVVTEPLIIPVAPQSGGNWIGVDDQQEVPNFISFVEVLLRFHAFRWGSSDITTLKHKRLSLEQACRAVGFYLPKHGSDILVDEVDRAPKFVAWVSLMLDKTTPPPSDWWWLHADSCDRLKNVLLTKGYPLRLSVLHDEEGDRHWWCLRRVSQPNSLRIIVVEDPTVASAAFQSRLGWDDVTRWMVSSGISFHMLTYSKTGTCEPAPSSDLRSALRLTLRPLGHKFTALDFEAYECSRRFLFRNPRIARAALLAGGILWRLAIEDVPLDIALEGPDPISFQEGSGFRLQDKTGSIYVDDELSEEEIGSIVGMYFEQSDRSRLNWGDDTYPMWWPVPRYFKATALDFPTWTPVDENWYPADFPTPPPAYPFVLIIVVRSSNPPSAIPPPSAIAPPIAVPPPSAIAPPIAVPPPSAIPPPIAVPPPSAIAPPIAVPPPSAIPPPSAVPPPSAIPPPLLLWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1B2</accession>
    <name>A0A2G8S1B2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Transaldolase</fullName>
            <ecNumber evidence="3 9">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="3 9"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1B2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1B2"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL27551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="326" mass="35869" checksum="7FD9D0D1B6155F2F" modified="2018-01-31" version="1">MTTSLDALKQTGTVVVSDSGDFESIDVYKPQDATTNPSLILAAANKPQYQRLIGAAVEQGKQKGGSIDDQTNAAMDRLLVEFGKEILKIIPGRVSTEVDARLSYDKEATKKKAKELIALYDSVGVKKERVLIKIASTWEGIQAARELERDDGIHCNLTLLFGFAQAVACAEAGVTLISPFVGRILDWYKKNKPGKDYVGDEDPGVQSVKKIFNYYKQHNYKTIVMGASFRNTGEIKALAGVDFLTIAPSLLEELKNDTVAVPKKLDASFAAKSDPIPKITYIDNEPEFRWALCDDEMATDKLNEGIRKFAQDGETLKALLRKKLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1M2</accession>
    <name>A0A2G8S1M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1M2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1M2"/>
    <dbReference type="OrthoDB" id="2757362at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="716" mass="79213" checksum="35DEABB5CE9B37CF" modified="2018-01-31" version="1">MSISALPIELLQIIFRTVRDDLLAADEEDMSWMSLARVSRHWRDVLRGDPFLWTRLAFTDKTPFYVVEAALDRSQQVGGVDLKFTASSSDPPSACGWLMHLSMGWPLSTYTLPGTVRFLSFLWREGVRNTVFEGLEGLRADGVVSLVLEEHEDPEDFDGDDDGALLESSSDCGSIVSGDDTEADSESETENADDEDNSDGDHGEGASNDDTDADTDSGTDTDSGLDGHWDGPVLDDASYEDESSDVSISDSTFSLGDDSSTYLDSESDRGKYLSELEDEEGGPATGTESGDDHDADHEDFNEDTSEEETSSQASDPAEGENDGNAVEPVQVESPRILQLPEFPSLINLAASSVLVSIPLQVKGQLTDMTLMHSSSLGHEYKGVEFRQSWMLDVLDGCVQLGSLRLCNTLIVTGDDPEERTVFLPSLKHLRVEDVLGGVQDILRFFMPFPEELTRMDLRSLLCTEHWTPVLEGAFAGNLPEDFTVPHFADTVALNLQVDDEFVLRGQTSTLLQWDLRAMRDPEDWSENATELLLQHAVLDLWDPRIVAATSISTLAIHIAPQYVTREVNWAGLISGLPCVSKFELGGDEAVATFIEATRPGRGVTYWPALTEFCFCLAIFRWDLETHMQYLCEQLWPSDGSPEHGLGVKVYLRLPGVYSPLEPGVARPHWFGSDYIYSAMNALSRDYDGRIQLLGHRCKTCHQPAEWVDVTYANPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2L0</accession>
    <name>A0A2G8S2L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000031">
        <property type="protein sequence ID" value="PIL27977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2L0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2L0"/>
    <dbReference type="OrthoDB" id="3609at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF43">
        <property type="entry name" value="KETOPANTOATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="313"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41224" checksum="7099E9CF7C1BA0D8" modified="2018-01-31" version="1">MTANGMNFRSRKYGDHQGWRPDRLFPTISDALDRPYSHVVLTTKAIPELQTTPSLLHPLLSPPYADTHPQPTYVLMQNGLNVEVALYDALKKLKPQEEPRIISTAVWIGTGLLDKNLVEHNEFDRVSLGVYRPPSPSGSISPPTENTPSEAALLASFADMLAQGGSETTVVHEIQRVKFAKNLWNSVLGAAAALTRLSLRDVFRPPHLAPGYPSPPPPESQSESTSARASASERATAKIPRASEAIGLYTIPFLYDTLTEVHTLGTVLFPPSFSGCSSHSPSSDGDGGGDGAGAPAVPGLDPSLALKTLANTARLHARPDSTHLPSMLMDVQAGRPMEVEHVVGEVVRMGRAAGVDVPRMEALYALLLVMQNQLLRQQREGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2V0</accession>
    <name>A0A2G8S2V0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000029">
        <property type="protein sequence ID" value="PIL28074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2V0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553572" description="Transporter" evidence="2">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9348" checksum="6E89A1B4EAC1DCE4" modified="2018-01-31" version="1">MRVPTVAVALLAAALSGTAGATLVKSESPEAAAASPDSDRTYLAPGHKDYAGHADSDAPVELKRQLDDAYDTVTSATRCERDLVGTPNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2X4</accession>
    <name>A0A2G8S2X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2X4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="193" mass="21169" checksum="7BF416BBA6B3B3D5" modified="2018-01-31" version="1">MGPVCSYEVYQWFGSVPAFLPTHLPTSSPDVRVSSAPTSPSTIRSTPNSPRTRNLCSLNSSLSLPLRPPWGILGCRLDCTPASGENWHPASLSQRISHLPPTLERLEFEQFTVDPAEICAITHAHARVYASSPSTMQCSALVRHGVPHRRAAAHSILHCFLALVFYILGLGCFVRLAMLIARRRPQQGFGWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3R0</accession>
    <name>A0A2G8S3R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3R0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013876654" evidence="2">
        <location>
            <begin position="20"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="10352" checksum="D71D025326FFC884" modified="2018-01-31" version="1">MKLIAPFVLLASLVSSSVGQDNFTVSVADHTQCATTVITWESGVGYAVEIQVSENNGHNALLAQYTIEPSCSSNASGRADASDEHAAVTARPGTSVKRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3V6</accession>
    <name>A0A2G8S3V6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3V6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3V6"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="272" mass="29624" checksum="E9A87DC8761062AB" modified="2018-01-31" version="1">MSNAGTTPAPPQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLASAHFCAADDKEAAIAELVKLCKGQHNIGTVQDYTVKFNAIAARTSFSAEDKRERYRTGLPYKIKDILATSGHDTSSITKIQAVALTMDQNLLVREEERPKQFSGGWRKKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSGETTDLAALRAELKEIKERLSAVSVKETKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4G1</accession>
    <name>A0A2G8S4G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4G1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4G1"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="479" mass="49714" checksum="9A58152119CBCC1C" modified="2018-01-31" version="1">MLTAVCVHLLSIANKPQLGLRAATLAPHLEILALAVGCSMLLSRTALPFILTNLVSALGDPSPPSTVVSLTSTVKAQVAMLTPVNFPPNITLCEPVNFTWTGGTPPYWLYVYGDVSGKLVAQNTTGIPTTWFVWIPDIPAVPGSSLRFQIGDSATHTTVSLSQLVGSESEGSSCLGSSSTAAAATASSTVVVTSPGQSTGPSHSTNDDSDTTPSSSQPTTVSQSAAIPVGTHRGERLSRAAVAGIAAAATFVGIAIVVLAWFATVSARRKRRVRLELEPGQADFDASPYPCTCPITTSTTSGHASGGVPLSQIPPNSTTLDLVNQSPPVPPPATTDSESERGYSVMADVGGPRLGGASPVSRRPSLEMATDPLSSAMGNLGLSQPEVLVNLNRLPHQAQELGRKRGWVPVAPHPRELAELRVECDGVTVLGVSDSEGMRTNRGALEPEHGVRHSLGRAEVNGWEVRSPSDGTALPPYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Q6</accession>
    <name>A0A2G8S4Q6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Q6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4Q6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="134" mass="15239" checksum="C03CC09A21D8C150" modified="2018-01-31" version="1">MMSHRSDINYFKCPLAPPTVVSTKQQRYRFRQRLLATFEPRYHLDRCVLRRSTSFGAGPLLLRSVFADQIKTASLLKRINSFGTLSIGKRASAFLDCATCDDVVAKVGWQSCGLNFLRTESNLFGGKFVTFEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S585</accession>
    <name>A0A2G8S585_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S585"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="197" mass="21303" checksum="5E2D58079CA097F2" modified="2018-01-31" version="1">MKAVNKTSSCISTFKGNASMPWKPEGQRNTQRKQQRRSYFRATQAAHHGTNKAPSLTFPRRGIVCMQYQSAQESESEAGIKQWQRPRRSLKIRTLTLSHGSPSRPTPHQRLTPSPGRRTRRVPRRAPSSSPPALWAAAAPRSAAPRASPVAARRAGRRTCPTSASQGGSARPCPRRTARARARSGPSSASAGGCSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5A5</accession>
    <name>A0A2G8S5A5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5A5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="164" mass="17395" checksum="F773F3FA5C3F0E42" modified="2018-01-31" version="1">MRSSRARTWLTVHFSSFSNRRVIVRRVPGTSSAPCALNCAYSGCVARDGDAPSASESAPLMGEAARLGGVLTTPRGMGDGEEDMARPGEAESPSFMKAGSSNLPSGVVGHSLLFLRSCFSIFFFSFSITLSRCFVSWMICCAGVRDSLVGVSLCLAADHQPPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5D6</accession>
    <name>A0A2G8S5D6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5D6"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44729" checksum="393C3634970CCD0B" modified="2018-01-31" version="1">MAVYDTLEVHRSQLHLRNVLHRDMSSYNSLMCSIWGDVEGRKVNQHLPPMIQDVLAGSTRPVEKRFPSCLSIDYDNAALLDSEDVSPDDLKHRTGTPMYIARGVCLGAVFTGLSFCIAPAMPKLSGEALALYVRAHGEQRYGRYNDRARHGAFPDNTEQQYMQPPAFRHRPEHDVESVYWSMVSALLRVHPKNADRETRADKNMVQTWDILLSHDIPDQSSTSSDTRQAIIIKPYPSWEALFLGDMKDIGALLFKISEHVNPEYALWGDGLHPDHLHEAVQRLILQYLVDHKEPIELDPEYTRPITASIKSANPTEQVSTMGTTTGIVSHGKRLTRASVRSASSQTRVDAESATGSASKPEGKSVDIDIARSGSSSGTRVPDASAQSSSTRSAGALARSDGARSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6C1</accession>
    <name>A0A2G8S6C1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_09362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6C1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6C1"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL29311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="354" mass="37811" checksum="F808600B37ED653F" modified="2018-01-31" version="1">MAPHSSNPPASRALVAGTVSFYLVAALAMIMANKWVLNNTDTPLFFLLSQLVIAVVLFLFAHISGLLQLPLQLDMQVCKGLIPMVGLNVIGLSFSNYTLKYVDASFYQVARGMVLPFTVGTSFFLLSARPSLRILAACAVVTGGFFVGVFLDGTKVSMVGVAFGVTSSMITALHSVVIKKSLDVVHGSALHLSWYTNLLSAFVLAPVIVLVGELPGVTKLLFGPNQAAAGEMSTLSTFVSGSIITGVFGFLMSVASLMSIKVTSPITHMVSSAVRGVAASLLAVWLFKDVVTQGRWSSIAIILLGSIWYTWIKHQESQPAQHQAKGYEPVPLNEMEEGKANSPSLTRASRDARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6H9</accession>
    <name>A0A2G8S6H9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6H9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6H9"/>
    <dbReference type="OrthoDB" id="2686083at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013762230" description="Transporter" evidence="3">
        <location>
            <begin position="19"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="52240" checksum="D7D736C415EBD917" modified="2018-01-31" version="1">MTLNILVSFSLLALVVTARPLSDAPQSAKRSLQIQNAVQAIFQSRTGQSPDCLACDDDNDVHVSITTTEEQSALLSTLDDLDAVKAVIPLSVHGSPSDDEKQLYDLLSSLKSTGSLNDIDGNVLPLPQNAADALTPKPAPQEDPAFPDNVAQESPASSFPDLYSSPPLVILAVSCIAALLTVLCLGAGLYAYNRINSIMIKSGLAWDVLPHLERRAGLDMSHDNSEGGSTPPPEKRRLILDAPLPPASVIQDKSGDDLNEKVLLVDIAEPFSDIEDVDEKFHDAQEHSLLFLDSDLPPQYQSQPDVPRIVVEEHADPDLLPLPDVPVDHSTPFSTPLQVSLHAPLPSPTRSPARRTPQMRELQASPTLMSKPLWSVRAADAPSLGLADQASSPATFSRTEYPTPQPPGALFADDAPEMVEVQRPRPRMPRQPLDIAFALQLRPGLGLGADSAWLVRFLMAMFGWMTFFIGGSPRQDGGRRALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6J5</accession>
    <name>A0A2G8S6J5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6J5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013856372" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11895" checksum="9C02FA227E20C2E4" modified="2018-01-31" version="1">MRFCFLLFISDSTTHASLARCSWIDACLFSLSSRGPRPSVFIRRDEHVEHARVLSLVVQNQAICRPDDSREELDEFESARSSRERLLEGVSQWHEILDSRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8N1</accession>
    <name>A0A2G8S8N1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8N1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8N1"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="589"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="947" mass="105235" checksum="BA6A8D5C5081BE1B" modified="2018-01-31" version="1">MSGIRAPSYLFSAPRTRRPTLSTRLLRSYYDYSYGYREQRHFTLPDYTPAQLENRTANAPLLRYVDSLRTHGHRAARIDPLDLLQREEVGALTPERYGLDDPSRTYDINGIVWTRPVGEDAGPEHWTLDKITRHLRDVYVGRIAYEYMHSPSKTERLWFSHLLEAEREEARGVGGEHQKRIHKLLAESEVFDQFLQLKFPSLKRYGLEGGESMLPALDALFASSAQAGVEHIIVGMPHRGRLNLLTGMLQFPPSALFHKIKGGSELPEEYGAAGDVISHLTTSPRLEYAGASKPIQVSLLPNPSHLEAINPVALGKTRAKQFALLKTLQRAGETECMPGDRVMCVQLHGDASFTGQGVIMEGLGLSNLPHYTVGGSVHLVVNNSIGYTTPASSARSSLYCSDVAKMINAPVLHVNGDYPEDVQRAIDVAFKYRNYFRKDIIVDLIVYRRWGHNELDEPAFTQPLMYEKIRSRRSVPALYEEHLINENVLTKDVAEVVRAHHKDFLASELAAAPAHIPGSNLTMHSGQWSGITWPGSSDAVRDPETGVEEETLKAVGRASVTVPEGFEIHPRLQRHVKNRTQAMENGKGLDWATAEALAFGSLMLEGYDVRISGQDVGRGTFSQRHAMLVDQRTEGVVVPLNLALDCSGKLELANSSLSEMAVLGFEYGVSWEKPDILPIWEAQFGDFFNGAQVMIDTFIASGETKWLKQSGIVLLLPHGLDGAGPEHSSSRIERMLQLSSDPYEFHEGSEAANVNMHVTFPTTPAQYFHLLRRQVKRNFRKPLIVAGPKGLLRLPAAASTLDELTAGHKFRPVLDDPAIAVPGDVARVVLLSGKLYYDLVKEREKRQLDGKIAFVRVEELSPFPFAAVRDVLARYEGAESVVWLQEEPRNQGAWTHVAPRLDAVMERLGRERVAFAGRREDAVPAPGVASLYAAQQKAVLEAAFVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S915</accession>
    <name>A0A2G8S915_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S915"/>
    <dbReference type="STRING" id="1077348.A0A2G8S915"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013742023" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL30038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="614" mass="64640" checksum="1BC2AE3880E3B877" modified="2018-01-31" version="1">MSSRSLAALAVGAVALFSRSASAGGITSDVSGIAGQTYDYIVVGAGLAGTTVAARLAENSAISILLIEAGGDDRGNSQVYDIYEYAQAFNGPLDWAWQSDRGKVLRGGKTLGGSSSINGGHWTRGLNAQYDAMSSLLEDSEQSVGWNWNGLFSYMKKAETFSAPNSQQAAKGAQSIASYHGTTGPVQVTYPDLMYGGPQMTDFVNTIVGITGINHYKDLNGGTPNCVSITPLNLDWHRNDYRSSSIEAYYTPVQDQRQGWTILIQHQATKILFQKGTSVPHVATGVEFGSADGSGSRQVAYARKEVIVAAGAINTPAFLQLSGIGDSAVLGALGIDTLVDLKTVGKNFQEQTMNSLGARGNGFNKGGRGPTDAIAYPNIYQLFGSNAAASVQKIQSSIGNWAQSQAENALSAEALQTIFGIQAGLIINNNAPVAELFFDSGYPDDLGIDMWQLLPFSRGNVTITSADPFTKPAVNVNYFSVDWDLDVQIAGARLSRKVLSTSPLADLRSSVGETFPGLATVPDNGDGGSDADWTSWINQDGTGAGFSAVSHPIGTAAMMRRSLGGVVDAQLKVYDTANVRVVDASVLPLQISAHLQSTLYGVAEKAADLIKAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S991</accession>
    <name>A0A2G8S991_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S991"/>
    <dbReference type="STRING" id="1077348.A0A2G8S991"/>
    <dbReference type="OrthoDB" id="2804491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72861" checksum="793BF125DB8647EA" modified="2018-01-31" version="1">MATDLIHDGQTLTDPESLWPAFNQTFHAATHRPVDHSILEDIEQLTPRDWPPFSSQELKDAIKNTTTSSAPGVDHIHWRHLKFFIDPKKNPKTADKILQGFRTLFNACIQYNVWPEEFRRAVTVIIPKPNKPDYSKIKAYRPIVLLSCTAKVAREAPGRSPPSTLSTSYKLTFGEDGTKAWSPPCWVFDIAQFFPSVNHGLLVNILRRYGFSPTFCAFIATTSLLGSHHFASAIQPPLTLNAPTSGSDRAPLSLPRSLPSTWPLSSMPYTAPPPYNPNSPYSFYVDDGNLVATSDSTETNCDIIRIVYTQLSQRLLRHGLLVEHDKDELIHFPPPTKKPKTPFAFEDVPLNLGTGPWSADHPLQPSTMIKHLGFLLDKKLSFREHIKHYASKGNVTALAYRMLGTSIRGLTAFQRRKLFISCIRPILTYGSPCLNTAMRWITGTFCYTPSGFLPIVSALEPLHAYLQKLRKRYLLRIHMLMDSHPIRSLFPNLYKRSYHSPYIRFYPTPSKPKIGVYQGGISSLDDAPCEPPQTSADGDISYFHDFPECTDSYNPLDDECRPGARIIDIFRNRITLELQHPPKSDSEILQKWIQTVLTPRIRATRDDPTRLHAFTDGSASSKGGKSSAGYILFHGVMNRHYELHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S992</accession>
    <name>A0A2G8S992_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S992"/>
    <dbReference type="STRING" id="1077348.A0A2G8S992"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="138"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="242"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL30319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="331" mass="35706" checksum="7845E29533E94F23" modified="2018-01-31" version="1">MAAAASHSAQSPSKSWLPAKSWHHFVAGGVGGMCGAIVTSPFDVVKTRLQSDMFRAKHVGVTIQANGAAAVTVRRNLLWHFVETVHIIRDIYRDESPRALFKGLGPTLVGVVPARSINFFTYGNGKQVIANTFNHGQENSWVHLAAAAVAGVATGTATNPIWVVKTRLQLDAHRPEFVGSGKSFFGGSVGTIKQILRDEGVRGFYKGLSASYLGVTEGTIQWVLYERLKKLTGGTKGKGGVQEWVGMIGSAGTAKCVASLITYPHEVLRTRLRQPLVDGKVKYTGLWQTLRLVIAEEGAGSLYGGLSAHLMRVIPNAAVMFFIYEAVLRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9J3</accession>
    <name>A0A2G8S9J3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_07426</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9J3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9J3"/>
    <dbReference type="OrthoDB" id="3248974at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL30248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7344" checksum="EB727F1F1CD5B04A" modified="2018-01-31" version="1">MQKLNVPRACSGRFFASNMLKAVLAHILLRYDLKFAGDGARPPNAYVSLAVVPARNGRVLFKKREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9M9</accession>
    <name>A0A2G8S9M9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex I-B15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9M9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9M9"/>
    <dbReference type="OrthoDB" id="15108at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39476">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE 6.6KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9375" checksum="8DD2D2D8287AD75E" modified="2018-01-31" version="1">MAGHGYTKTDPAVERWNTMREAVYKHFRFNSRTARQSILGMIVFPAAVFAVAYQQNGRYDWTGKRKGEPLARGAPQPAAEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9V5</accession>
    <name>A0A2G8S9V5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S9V5"/>
    <dbReference type="OrthoDB" id="3259825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1536"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1588"/>
            <end position="1640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1110"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1249"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1640" mass="175244" checksum="83E740C58CE8DF26" modified="2018-01-31" version="1">MLQWYSLTRRFSVLRNSSGEPIGLDELKSKFAEQRARGSQNQVTEEEEDMILEALGRFHGRSRSRGKQRARGAEDGRGSAAEGEDDDADPVHQAVRSSDSTTTPSLRGASSMASISSAKGSLSSRRMSNNLFGSGKFRDQAYFLRTANPRRGGRATGSIAQSESNASMSTVESARGEHNTSMYSDNQSLRPTTPEDSTYTFGSAPSSPGNASTLSKDRSSRSILGEQSDYSSTLSRRLSKALSPDGLKRASLALDQAIKELEEEGDDEIVMERSPIAHVPPSTINGSLSALNTAVESDSSPAVSPSEVETGTALSSDDPVAADDARGSSPHPGSRTTSPTPRLPGYIPGMPRPMTPRDTSFDTEDLTPSATPRATSPRLPSLNTQASPLISQTFTSSMYRSNSSASTYSTNRPISPATATTPPLFFNRSMNGRYTPEERQRNGNRQSSPTSDTAESPILGRRRPISPLSGPAYQPMTSPPSRPTTPSNVTWNVPSSQNGTPQKPLGRNGNVAGHSRNGSTTSVNDQTEQLERAKSTTRSLRSPALPDSPWVDVGLEYRPPSAMSGMDLGSPAQGTHSIVRSPTPNGAASPASPAYADVGGVDDGRTMSRRSSKHHSSYTFSLGQPNALLFSPLANSSRSSLESAGSSYHSWDEDHKKDRLFGLFSGLDPDNTPWHDISPDKSAPSTAGTSPYDSTETEDAVRKEVGLSKGDFIVMQDKLVGAALAKAVTPENRRAGSIRRRRPSTSQSNYSYNGESRAVNTTPQPQPQPQPQPQMVATSSRAATSEQVARANALLNAVVDSIESPRVRPPDSLPAEEPTLVVPQVTDIEQSSPMRRNRALAEALFGAEDAEVSAPAPQISIMPEMSDDESLIRPVLTPIKPLSPKRTDSLHRLISQNPPITPPTRTMPTSPTLPLSPASVPLPMTPTGIPMSPGFMTSSPGGLLSPLSPSSNMDPISLALEVQRRAEAATAALRKSPSIPKMVEGNGGTLPRKRISPDKISAPTLVSASTSVDAIPLRSPTATPIPTPAQQQQASKIGSRFKKLRGTIRAKHPTPSGEEVTPYPLDLRSAGSDATGSSSPSLALRTDPITIHSAGVEPSRLKPPTPLASPPASAAPGLKGFMARFRKQRNASEAHAAPQSHPSPHHQAYAPMSATPSRPGTSSGPFVEHTYAQMPRSAPALQTVFRSTSPVGSQAPSQSPTPKPPQDYLGQHSRVASQPGSDEDAIKQLFHAAENLGLDQAALNELLARSPSTSSRSTAWTQLTRATSLNNSRKSHIPVIRGRATPESIRSPMSDGRPSVDGFSPRPSMDTKPSGRRSQDAPLALRPRPQQQHYSSQQEAVPNAIVRRTIIFPSDARMSSLDFQAMMRKQTNSRRRASVSSKSSVHDRVPTPPPPHRAAGRRFSTDVSPPVPQLPPALSVQNDAYLGVPSPVDKNGSAYDSLYEMYSSDNRGMIVAEAPGGASSQVQEGVPESGPALEVIELANGETIWSIVNGLRDDDGESFYGDRASFYSEYSVKDNDNVKLFFKEHERKNSRGSVNSFLSRKKPAPPQQPHASKGAARPETKVFFSTSAQIGRLIENLSRGMDAGSFNILPGQGQGAPPTRHTQPGHSTSSSLGSEADMPWSVEERLERMLGSMGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA50</accession>
    <name>A0A2G8SA50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA50"/>
    <dbReference type="OrthoDB" id="2732452at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="670" mass="74494" checksum="83B7421B590AE751" modified="2018-01-31" version="1">MDPLRNIPRLSELSGHLQQLLPTDRGAFSTLTTIPDIQAWAVAKADEYRQLALALLAIHNLAAPIHRLPTEVLERVFSNCWQDWNSLRLPHVCRLWRSILLDRPEFWADAVAKCEFQEKREIVRSELPLIDSLLSRSTQHSHTINPNFYIFPPAIVQVMAPYSSSIASLHVTVGKIDLQDGLWPALLSGMPNLETLTIQITMAGEDLNECRTMGYIDLMQSDHSPAWSELPMLSRDALPKLSCLTCPHSMVGRFSDVPLRHLKAEVVVMTPSSSQRSFEWYLPKVVLGRPQGLHLEPHRSRLETLEIMPTGIVEEDSYATPLEPLDLFSLRRLRIEGDKDVVPHILLWLRLPQAASVHIPRFYAYSDDLGTKLRSVVDTIDRACLQYLDRRSGMVHQYRMQCFAGGIDRLRIDELCTADSSALISVFGENAPVAHLELSAKSSYLLMNNFDLHAFPHLVHLDLNGSNLRALGYLLQPALHPTRRAGSGWGIADADDSPLPSLKLSELVISCPPPESKYIPGHLNTDTDTDFSTKVDELFREYFGVFQQALMDRAACGTRLTYLALSLPPATRTTEASKAQAKEPEAGAGDQEQARSKEKAGCDGGSDNNANPGSGSNEMAKHKEPAKPCAFWPSHAARLTALESLRELVDGPVVLKLLDDAGNEISVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB81</accession>
    <name>A0A2G8SB81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB81"/>
    <dbReference type="OrthoDB" id="2756328at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="190" mass="20441" checksum="3385593951D206CE" modified="2018-01-31" version="1">MSNWSIEFSSCSVTGHAWGKTIQDEFAAYDACLFVLVHSSGSVYLTIVEKGCDDLLVLDFGAFSQDATLKRWGSSRITYRGEHGGLFLAFPDGADLEGFEDCCDRILRVFRVPGVAPKVKDLQDLGVIPLPRLVGGFLTGLVDNDVPDPLLLGSDDSSVSSLDTNSTVDTVDAFTEEELAVISGELQGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBN2</accession>
    <name>A0A2G8SBN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Alpha-amylase</fullName>
            <ecNumber evidence="4 12">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_05872</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 12"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBN2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBN2"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11317">
        <property type="entry name" value="AmyAc_bac_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031319">
        <property type="entry name" value="A-amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00632">
        <property type="entry name" value="Aamy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013647913" description="Alpha-amylase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="16">
        <location>
            <begin position="44"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-amylase C-terminal" evidence="15">
        <location>
            <begin position="398"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL31175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="555" mass="59208" checksum="D8BCDA3B18CBE461" modified="2018-01-31" version="1">MTWSKLSTLLTLGALYAAVQGRPFLVSARNGTSLARRAPSTEKSVIVQMFEWTWDSVAAECTDFIGPAGYGFVQVSPAQEHVTGDQWWTDYQPVSYILTSKRGNRAQFANMIATCHAAGVGVIADTIWNHMTAKDNGTGVAGSSYTHYTYPGIYQNQDFHHCGLEPGDDIVKYDSRAEVQTCELVNLADLRTETEYVRGRLAEYGNDLLSLGVDGLRLDAAKHIDTKDIAAIVSQLKTTPYITQEVVYGTGEPVTPNEYEGNGDVQEFRYTTALLKAFSGEGISSLQSFDNLGWVKGSGANVFVTNHDTERNGASLNNNSPSNTYVSALIFSLAHPYGTPTILSSYSGFTDTSVGAPNGGVGTCIGSGGKNGWLCQHRWIAVAGMVGFRNNVGVAALTNWVSPQSQQIAFGRGDRGFVAINNADSAWSTTFSTSLPNGSYCDVVHGSAFDGFCTGSSFTVSGGSFSATVPARDSIAIHTGAKGSGSGSGGGVINFVKAAETTFGEDLATRELESSKRRTSFECKFIRKETDGSVVWESGPNRSDTAPSSGSHPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBR3</accession>
    <name>A0A2G8SBR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBR3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBR3"/>
    <dbReference type="OrthoDB" id="2642524at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="518" mass="58171" checksum="AF54090D03776745" modified="2018-01-31" version="1">MAFTEAPHPRCSPFHITVVRMSGPLLLRCEEPERLILSIAVVDNDYDPGLRQEVALGRDGQNLNLESAIPVHEVKATTKLIIEVYRPLEDKKKHMGRFLAGFAFLSLQEFLNEHPPLPRLGSVDYDIQLARYPPQCKSPTFEYGATVTMRFELHKSEPGPSQPESAPSSSIPKHDETRPLLSDAPSSSRAPSRTLATNTPDETGREREQRGWGKQEGHNRPSGKKLHGFHVDSDSGAETPSEDEHFPTVYEDEPRFKFRSADEEDGYAYEDEDEEDEEDEEETFSPSELPVPYAFPERVGRVGEGTFEERFLRWISPYEEITEAAESRDREKAEKVLARLQTEWDVVLPSSLRLLLVGAVVAAVMARFAPESLKFLAPEGFPREALALAVLAASFGTEFSAVLLFLYGLCTNGVKFLAIVQDMYDTYILFSLTCRLPIFCMTISLVSSMAFLLALACTAWPTAMLVMSFITGLLLTTELIVFGTSRLVNFAIWFKRGAWRALVWFSGCTPRCPEAYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCC3</accession>
    <name>A0A2G8SCC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCC3"/>
    <dbReference type="OrthoDB" id="4095724at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="139" mass="13961" checksum="60D5C76412437ACC" modified="2018-01-31" version="1">MRYTAGDDGVQALTISEITTLQRPITASAATVVQRNFIDDFTSAGNVASDALSGIEHVGTIVTSVAGHDFTLLTADGGHVLTLAASGEGIATSIAGTLYTIATADVGNALNGALSLPGPLLGGFLTASVSMMLGAFMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCF4</accession>
    <name>A0A2G8SCF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCF4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="88" mass="8765" checksum="F0E533A2B6F61193" modified="2018-01-31" version="1">MKANIAKTTIPPAAPRERDNDCCTDPGSGGDGDGGSGGDKLDGKEEDEVSAEADISTNTFVAAMALGGRDADGCVEPVAIGGGDNVWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD72</accession>
    <name>A0A2G8SD72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="6">6.3.3.1</ecNumber>
            <ecNumber evidence="7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">GSI_06412</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="6"/>
    <dbReference type="EC" id="6.3.4.13" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD72"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD72"/>
    <dbReference type="OrthoDB" id="2018833at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000006">
        <property type="entry name" value="Phosphoribosylamine--glycine ligase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000011">
        <property type="entry name" value="Phosphoribosylformylglycinamidine cyclo-ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000018">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.600.10:FF:000001">
        <property type="entry name" value="Trifunctional purine biosynthetic protein adenosine-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="entry name" value="Phosphoribosylglycinamide synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520:SF12">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01209">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="26">
        <location>
            <begin position="138"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PIL31709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="772" mass="80827" checksum="ED60A5CD5A941D6B" modified="2018-01-31" version="1">MGASSLSPGSGDGPGPRLDLAASSCDMPRLTILVIGSGGREHALAWRLSQSPTVHKIYVCPGNGGTALESKAVNVNISPADFPALVDFALKNEVNLVIPGPEQPLVDGVESYFRKVGIPVFGPSALAARMEGSKAFSKAFMDRHKIPTAKFKTFRSSEVDQAIDYVRTCGFKVVLKADGLAAGKGVLLPETVDEAIAGLKAILVDNVFGAAGSEVVVEELLTGPEVSVLAFSDGYTIVPLPAAQDHKRIGEGDIGPNTGGMGAYAPAPVATPTVMESILKDTLQPTISGMRKEGYPFVGMLFTGLMITADGPKVLEYNVRFGDPETEALVLLLDPQTDLAAILLACAEHRLDSVDIKARQGYSVSVVLASQGYPGSYAKGKEISIGQMPSDVVAFHAGTIVVDGKVVTSGGRVLCVAAYAPTLQSALDAAYAGVSNVLFEGKVFRRDIAYRALSAQTEEPKGLTYAQAGVSVDAGNALVEAIKPFVRATRRSGADAEIGGFGGVFDLKATGYNDPVLGAEPLYFLDYFACSKLDVQTASRVVKGITDGCIQAGCALIGGETAEMPSMYHGDDYDLAGFAVGAVERHLILPQPTIAPGDILFGLPSSGLHSNGFSLVRKVITLAGLSYGDPCPWDTSITLGRALLEPTRIYVNGVLPAAQAGLLKGMSHITGGGFVENIPRVLPPGTGCFIDASTWELPPVFRFLMQHGGVAPLEMARTFNNGIGMVLVVAPEAAERVMEVLQSAGETTVVRLGEVAAQAGVEMRNLDAWALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDG0</accession>
    <name>A0A2G8SDG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDG0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDG0"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF8">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="511" mass="56123" checksum="C81786CD274CACC6" modified="2018-01-31" version="1">MVVTLDLDASTSDPPVRRQLANLSLAVAKCKKIVVVTGAGISCSCGIPDFRSSDGLYALVKQQYPDVVLKGRDLFDASLFRDPTSTAVFYTFISRLKKSIDVATPSPTHRFLKTLDSKRKLLRSYTQNIDGLEDRAGLVGTSSDEVKTHGKGKSKIKTKEVRNVQLHGDIHRVRCTFCSADYPCASEHLETFLAGTAPDCPECAVRSTARVARSARALKVGKLRPAIVLYDEPHPLGDDIGSIQSADIARKPDMLIIMGTSLKVHGFKKLVKDFARTVHESAPPPSACAGSPLKKNAKNFAGKVIFVNKTAPGSEWDGIIDYYVVGETDRWVEKVIEDWKKARPSDWEVQKTLVATGDAATGGSLHVAKEITNTMGTKVGKGAKRKPVRHRENAPLPEDEIWDITLPLPEAPPSPSKRPQSRCHYHDVESSPSKKSREGARAVREPIHFEERGLLFGNTTNSKVRSTPENDFDLGENIRKSKASKIPKPRIPTSRVEVVLELRPPSRKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDG8</accession>
    <name>A0A2G8SDG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDG8"/>
    <dbReference type="OrthoDB" id="3195323at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1026"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112447" checksum="FF3DF0112F24415F" modified="2018-01-31" version="1">MPPALAHTPSRPWWPRSKSSKDALRTRPSVSTIPGEDEKCPSPPSTSSKPKDALPARKFNTLASAIGFRSKKLPALTIQDPPSPCSPSHPYTYSRPGSGNSGSSSPAVVDRTPFFTNRPPAKSISTVRSSEYDYDAASDPHSEPRTPSDHPRDRLSYQHSVMTFTEMDPFASGGIIVQALPQDPNRLSVYSDSSMLDPQQKRPDIPPPMTHRVSYGSCSSNSHGNHSDVLSPLSATSFPRSPIASRSAYDLTQTYDQYPGDASAAQAQRTHRTKTPSGSNSSNSTVTQHEYRNRLSEPPAGMHLPRKRSSPSLARPRGMTVGAIDHQPSPASAPAVPDLPPLQLHRKESGSSSPSSSNTPSPSPVVFTRSRNASCTTLESPASPNSTQPKVLLRKASASRVYVPPLPAAPPTTSLPPTPNRLPPLPSSPYGLSPLEFRAFSSSSSLDFAPSVGPHDLEPDEPIFQIVNDHYDLGPFHAPPREAPKSKTRKNQSTDFLSGDSSSTRLSDFDLPSPIGKFPSVPTLVHGDMHPKAGKLLKKMPSQQSFSQRHSATSFMSTASGPPDDANGRVNGHATSVKTPRKQRSFHAPRGIPLPLPPLPGLRSSSGGSSSANETLPPPCSPILEPRRGNVMSPRKRLFSGSSARRSTSSHGPTSVTEVDDKRSVFSFESEVRPFTSSGTEMIGRSLDAIGGHSQGTRNGSISLPSLWDDGAGENETDKRMSQSDYVPQYIMSPAEQLKLAEKLEDEEAAASIHQSIHEEVGYPTRKPTLDLHPGDFGLTYSALPSATRSRSNSVLSHSSTGTLAFGDNVGVTRGTSILSSRSSIMSSTSRLSPTNSSPRKVSTVDHPRSVPSRTTSMLAKPVVRPPPLNVRPSTAQASVTPPRSPQRVCNPHTPHSPETPSASLPPPPRRRPSRHDLHDIEESTDRRNSVVPMNALSPPPIRPARLRRQDSTDTATTVVSRPPSAYDRRKALQRRSIMKKPSFLDIEDDFDQCMDNGSDEDEIEESLESPTMESSFLDMDHGKNSFDTVRSYDSASHVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDI5</accession>
    <name>A0A2G8SDI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDI5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDI5"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="280" mass="31024" checksum="B27CB48CC4028F1A" modified="2018-01-31" version="1">MLITSDKEATMQTTPPLNAELNTYGFPQGYFILRSLATDRVLDVAQGLLEDGTCVILWPMTETSLVESMRKPDSNNQVFFIDTSGALCSRSSGHAIDVQDEGLVLRHRKPVTYPFPNPESHPLPRFAYHPSTREITVTFAFDPSYPASPTSRRESADGVWKTKTYYLSSVPVRKPPTLIDNASALLTAAVAGGMSLFGPTRTNATPEEVFDGQIDLNESDLAEQDRNEAEEIDDSPDWLRPVKAIGLMTEETVGASDQAKLRRQWEILPLRHTKRLTGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEB8</accession>
    <name>A0A2G8SEB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06822</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEB8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEB8"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="282"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="408"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL32116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="517" mass="57449" checksum="A41D2D77940C98DB" modified="2018-01-31" version="1">MASSSKLTRGQIASAQINGDYAIKPESSQPQLDTSNWPLLLKNYDKLLVRSAHFVPIVAGCSPLKRDITSYVKSGVINLDKPSNPSSHEVVAWLRRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVAVLRLHSALPNPTALPRAIQTLTGALFQRPPLISAVKRQLRIRTIYESKLLEFDEKRNLAVFWVSCEAGTYIRTLCVHLGLLLGVGGHMQELRRVRSGALSENDDMVTMHDVLDAQWVYDNTRDESYLRRVIRPLESLLTGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEADIALHEEVVLMTTKGEAIALALAQMSTVELATCDHGVVAKVKRCIMERDTYPRRWGLGPKALEKKKMIKDGKLGKYGEVTENTPAEWSKDYVDYNREPAASTSAAPSVPAASEPAPAAVEASPSKEKEKDKEKKRKRKSEVPDADGDVTMAIDEEDEAARAERKRLKKEKKAAEKAAKGEDEDEDARRERKRLKKEKKARESLGVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEV1</accession>
    <name>A0A2G8SEV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEV1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEV1"/>
    <dbReference type="OrthoDB" id="3041043at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="205" mass="23439" checksum="16805E0692E781B0" modified="2018-01-31" version="1">MAEAFSVDKCLARFFPDPLAFRRIQARTSTLISGSFALQLFDRTSYPSSDLDLYLHLEHRRTVGRWLIDEAGYSFFPYRGQEEDFESAVLHKTSRRGISYAMPGVADILTFRKGHLDDAILKVQLIVARRTPMEVVLGFHSMASFTVRYDTYDGVIMTFSVLRSDALQYRYALGDEDLADYLSCILGFKKYENLNNLACGLEDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFP4</accession>
    <name>A0A2G8SFP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFP4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="76" mass="8017" checksum="6C17F4415B66BDD6" modified="2018-01-31" version="1">MFTLTVTSTDVNFRYFIFGGPAGEKSIRSAGELFRPQGAKYIVGVAGKGYLTLTDVGNTVHGPGDWAVHATGSADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFX4</accession>
    <name>A0A2G8SFX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Redoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05378</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFX4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFX4"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF39">
        <property type="entry name" value="PEROXISOMAL MEMBRANE ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Redoxin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="152" mass="16297" checksum="228B145B2F0DF77F" modified="2018-01-31" version="1">MASLLAGATKTAHHLATSLLSAAEVKVGSTIPVQVPVKEDAPDKTLTFESIKGKNVFVGVPGAFTVTCSEQVPQYIKAYEEFKQRGVDNIYIVMVNDVFVAKAWKEQLGSHSPVRFIADDQGAFTGALGMLFDASDLLGAPPMPHARSGTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG67</accession>
    <name>A0A2G8SG67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG67"/>
    <dbReference type="OrthoDB" id="2663142at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="312" mass="33964" checksum="9EEC36223BA23505" modified="2018-01-31" version="1">MVKMVFGDSFILDEVILRALSIIPTLQVLTGGTIRLGTSEVLNFGDGFCALGSLTLKGASTDLCTVLNDLPRSKLYSLTLSFTNSDGQFAAVAAHLPDTLTQYASTFCAPLGSDPMAVMDLIKPLLSKMPMLDDFRVVAEKSALSVANDDLILLGDAWPHLTRLTIRQCTTGPRSNLPDARRPLNVSGLAELARRCPKLTMLSLPELDASKPAEPRPAPFLGHRLKQLCFQGASSAPARALNEAAVAINIMFPHLELHEMQPRAKCPAKVDAAWAHIWNTLEIMRWGRRDYILSERGCESAVPEVPEMASDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGW9</accession>
    <name>A0A2G8SGW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGW9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="68" mass="7590" checksum="4E653EDD079510CD" modified="2018-01-31" version="1">MDGRQLFPETHHHLVPHRHGISEAHLRGAFEGAGLGAFEMHDAATLKLPNVLKEVRTTWFVARGVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGX1</accession>
    <name>A0A2G8SGX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGX1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGX1"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="15056" checksum="08C9A367709D545F" modified="2018-01-31" version="1">MARNKLKKDPGVPRLPSLKARNASKHLQPPPRSDPDSQMASEPTLSSLAALAASSSAVDDEAYSADPSSSNGAPKTKEQLRRHYVRSLHKVIDEADIIVLVLDARDPEGCRSRLVEEEVRRREAEGKRLVFVLNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIA5</accession>
    <name>A0A2G8SIA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_04114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIA5"/>
    <dbReference type="OrthoDB" id="2802092at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="158"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="447" mass="49054" checksum="05512CBFC8A1CE84" modified="2018-01-31" version="1">MSREETGLRAPNNYVFPIDNLVMTVAQWYQLYSRPEYRDTYIVLPKQTQRKGKQNSKSYAFSVELYINVGQYAARTEDPEIVGSGRAGAKRKTSAVSVGDVGKCSSSSKRPRETVSSQPARQTLRSTFIADGNLLAQTPSPISVVEIQFKKTTCLISEGSGSPTLMEESPLLSGFLETRPLDLIAGERGNSKDVFGLRIGTQSYVAKKLVNTGGGRSEEIPISQAINVLTADLIRLKRMAYFAEKFKAFAYDQGANIAEFDVSDAFLIKSYKPSTSTVPPVEHIDGDHEEDRAHAESIKEVSAVYLVEPLRLTTTVVKFSGTFGSTTRTELRSLTVSAYAHYVAEQTACRYIFADIQGSNNANASGKLSLTLFDPMTHTVEGTSGAGDHGREGLQDFVSNHTCNHICWAMQLASREVMQNTLTDIFRSQSGAATQDSENQENPSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIU7</accession>
    <name>A0A2G8SIU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIU7"/>
    <dbReference type="OrthoDB" id="3053346at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="275" mass="30369" checksum="6E412A3F91057173" modified="2018-01-31" version="1">MEGTLCCPLPHTYVAAQLDIQATIQNLDPLTQEAARTIKPAKCLLYLYDALRYPHPGTPTTFEAYIVGLGLRAEDPENGFTADMCVPIFPTTAHPNNRPAVLPKTRFPFSNCYHWAYVDILLRVSSGEFPGLGGSSRLIRLAAGEQARMDRLLTKDLTTAILAKKARRETSPRLGYDSEEDVFTCSTRKVPEDLLPIVTVSVDLSESLDETDLPDPVEFLRQYNALLCLAKESNARREVAVGDDAVSVSRTYTESDHSILRRDLEGKGVGRPGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ48</accession>
    <name>A0A2G8SJ48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ48"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="107" mass="12324" checksum="ED169C71B9955C1A" modified="2018-01-31" version="1">MAQAAKQTMPVRGEKTCPKFDEADPTSLHRYFDDLEALFVRHSMPDADQDDWKVRKELAVRYPPAAVEYGWKSLPEFTEVTKNYTDFQDAVYALYPGVTKDRDISTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ77</accession>
    <name>A0A2G8SJ77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ77"/>
    <dbReference type="OrthoDB" id="3008623at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="371" mass="42019" checksum="C4F0BBBEA098083E" modified="2018-01-31" version="1">MGKTTRKEGDPIVYRKTIESGLRMWVDAPDEQCRRDIADEYFDNPPERKPPTGECCDNCTHRRTRMIIASDDHSPPSSSSSTTAVQMASTTAAPDAVEVALLDRLDPANWAARTPALRRDNHLKQAQRLLEEWRNRTWLSRYKTQPFGAQGILPDSVLTSLASRTSFRTLEDVRELRWVLAKQHAAKVLKMLEELDREVALEEIAKEQARHDEEVARQMEKEAECERERIRKMIEAAKKLEAKEAEKARKAAEKEAKKKRKAAEKEAEKARKLAEKEAEKARKAVEKEAQKVRKAEEQAAEKARKAAEKAAEKALKKSDKTGGGKRAEGTKRKSLDKGDEPARKRPSSTFHLVHPLALVLSNVRVPPQILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJF8</accession>
    <name>A0A2G8SJF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJF8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJF8"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="253"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="916"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="962"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1115" mass="121751" checksum="1E158385B5312F32" modified="2018-01-31" version="1">MDTGSGGGTDVARSSISSTPRDRLTNVGYSLWEQRTATELNWEFRSTEMTSLSENTTVSEPRSRRVEDLGPPEDYRLSTASSASTTSTSSSFSSIQSLQSLLASPPLSPSITSPPIPPRSPLRNQHTVKGVPARPPHSPCLPDSLAPIAELTLELEPSLELEHSLDLYDPDMPLLHSRSFGSISGLLDQPLSAAMLHPRRSTTPDKPLPLTPQPSMSTPSLPIGADMEDEDDVTLLPDEDPSDTLCATTSMTKREYALRELLESERIYSNDLIFLRDLHMPLASGQPTAFNLGPATPPRSSASSARTLSTASDASTASYLGNQPPMTPEDVKIVFGNIEKLAAFSEEFARQLEPALGEVVEGGEGEDYVGRLFLDFIPQMEPIYKAYITKQATAVEHYNSLPRTPAFQAYLAQTQVLAQAHSNAWDLPSLLIKPVQRLLKYPLLLNTIIAETPDSHLDKDYLIEAHARVEVVARGVNEGRRQREVVRDVLASAAVIATPQKGAGAETIKAKKKGGLSVGVAASVNLGRMKTLRAAALKAKEGPEANAEAEAVKEMGARLKSHGPFMEKFAKGATKWADTVGALISALNEWAQTFGRVIWMDPEDERSEAFDAFLEVIGKSLLPLCEELKQVIKGDLLHTVTSLSDTMVAPVRLLEAMHTLEPLHYGLLNLNVAKSRPPPQLLEASQSYVALRAQLFAELPTYLELLDRGMAACITKLAVFQRYFYTGLRNRWGDLWDALKVDEEANQGAEETLRVWWDRFAEVQDHFSGLNIVRALEKKTTPEKQRVKPGKPHMNGSQATPAAMHVSSVLASLDPLNMGASQPSPSEFTFPMPPPSATAKPRSVHSAHSMECEISSTVSPRKSEDNFRSKKSGKPSKSRRTSSSSRTHSTTSTLIEPLPAYSGYGVPALAALVPVSPKTPSSRTQGTPLSPPLKKSHSASKYVNLDEEITPNHSSLSVNTVSGLLQDDGRGRPARKPSFRRRLTDTFKAGDTKHRRSPSLPDYRGHTPSPSPNAPTFPPPATSTRQRRSGGQVPSLYECRVIHPCEPPEGVEYRSLPFFTLVVDEVYDILQEAGHPSVHRDLPLYVDDGEDCLLLVRNDAGDIGWALASFMVPMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJK0</accession>
    <name>A0A2G8SJK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJK0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJK0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="431"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="695" mass="77921" checksum="7ACB6B5C8E1C5150" modified="2018-01-31" version="1">MWRPGRQTNTFSDRKGTFDPTDTRHVKHTKLEVWDFYEEREPKLARIPGSSSLEKYMDLLEGLPYVWRMVKDVLAIPTCAVLLLLYAVGQLGQAIFPALGLWYQGQLLNIVQVAIDTRTVDASHLLHVSAGRIMCSLAQRAMAILSFRVQEPLTARIGRWYGVRLFHARARLDLPTYETTNVQRQLDEVFPESDLGKIPVAFEALQTAAIFVRAGTQVLAQGFALMQVLGEHRDGLLLCVITGLSQGTMWFSQLNAMQPTRVWAATTTNEEYVKMQGWRRVVSDAAHRKEIVAGNLGEYASSEFKKASDKVGDKAGEFREQQRWEAVRQGFSLWTLFEHPFQYVPHIVFALRAIQYPASIPVSLASLHLIQSAMHGLIANFYRLANSTSSVAEQLAAVRKLYEVGNIKNKVQDGTVPFPEDASEIKSSVAVEFRNVSFKYPGAENYALRNISFKLAPGQLCVIVGVNGSGKSTILKLIVRLYDPDEEEILIGGHDIRTLKLHDLRQAISVLFQDFTHFPLSIRDNIAIGDPSAAGDDDHVRLAARLGGAESFIEKLPDGFNTYLDRPVRDLKERRHSSDAASTTARCGMQGIAVARTFMRSVVSEDTNVGLLLFDEPSASLDPVAEHDLFNRLRELRGSKTMLFSSHRFGNLTRHADLILYMNESVVVEAGTHEELLKREGEYANIWKLQAQAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJP0</accession>
    <name>A0A2G8SJP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJP0"/>
    <dbReference type="OrthoDB" id="1284551at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL33984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="435" mass="46665" checksum="77E99EB63436787D" modified="2018-01-31" version="1">MTQTTSLQYEAPWPVYALDWCKSAAPGQQMRPRSAFRLAIASLTSDYRNRLAIVGLQDERVLVEDDVDYADYPDFVTLVEAQHGYPATRLQWQPATANSFAWSQKAGVAELLATTGDALRVWEYASDGAAGGGAVGGGYVGRQSGGGGHRLTLKTALSGQSKVQNNNTGAPLTSFSWNEKSPSLVVTSSIDTTCTVWNIDTSTAITQLIAHDREVYDVAWLPGSTDIFVSVGADGSLRAFDLRSLEHSTILYETPAPKNVPPPSTSPSSSARPPTSPLLRIAFNPADSNYMSTFHMDGSDIQILDMRSPGQPVMELRAHRAQINALGWSSSDSRLLGTVGDDCQLLLWDLAQHTQNPNPAAASPRNASTGLSSPRPDAKKRVVTEPAMAYTAASEIVNMAWSPQIAGMQMNTGHSTAPGEWIAIAMGKSIKALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMN0</accession>
    <name>A0A2G8SMN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMN0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMN0"/>
    <dbReference type="OrthoDB" id="3270417at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="178"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="326" mass="35621" checksum="065DD04DE930F01B" modified="2018-01-31" version="1">MEQPSSPLALPPSALATIREALSCVVLGTIISTAVYGLTVLQAYIYFRHNNTSPRTRYFVAFLFALDTATIILTLYGFYDDFVTHFDDVLSFLKIPGTLALENLLTVLIGLLTQCFFAHRIWALSKGNVLLVSSIVILALCSFGPGVAISAHLWINTYIFSLGSLEVRMLAGFANGLSVICDLLIAAAMCMYLNTKRTGFRRTDSIIDRLMMYAINRGLLTATCQACHMILTIAFPGRLIYFPFALLDGKLYCNTLLATLNAQRAMRGDEPNIIEVGSHMLNPIDSSTAGHGSRRTLHGKLDSASASMPSIRKDFSGAGKAMVSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMQ5</accession>
    <name>A0A2G8SMQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMQ5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="17056" checksum="B57BA0EB2CF6D695" modified="2018-01-31" version="1">MSTRTSPFPAALDLEAIQAPLISATSPPDWASESDSSSIQSSPDIVHGARMACASSLIDPLDEIDLAALDDQHDNCVELRNGFLESPHRTVPQRSLLLQAHTRSESMDLRETCVPPFRDPTKRVNGHVDSRRPSTPQSSPLLEALTQPEARDVHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMZ1</accession>
    <name>A0A2G8SMZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02881</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMZ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMZ1"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="36591" checksum="6AB2E3EAE1D4935C" modified="2018-01-31" version="1">MRAVLVKDGRGPIENLYIGEAEKPVPGPGQVLVKVKFFGLNRMDLMQREGKYPLPPGVSIPEILGVEFSGHVEQAGEGVSEWVPGDEVLGLTAGGAYAEYVVAPRGNIAKKPAHLSWAEAASVPEVMLTAFQALVVIAEVKQGDNVLVHAGASGVGIAAIQLARLYGARTVTATASSKDKLDMLLQLPSGATHAVNYREQDFAEEVKRITGGKGVDVIIDFVAQSHWKQNINSLAYDGRMTMLALLSGTEVSKFDLAPIVFKRLRIQGSQLRARSVEYQADLVSRFEREVLDHITGAAGDGKVRVYIHEIYPWTKIQEAHREMEANKNSGKIVVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNM6</accession>
    <name>A0A2G8SNM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNM6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNM6"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="26990" checksum="9AC3052882112825" modified="2018-01-31" version="1">MSLCAQCISGVRHEGEPEGQIQTIAGVQVYVATPTIDYPKDKAILFLTDVFGLPLSNNKLLADDFARNGFKVYVPDYFDNDALPEDALNPGSNYDFMGWLGKHPAAGTLPTIRALIAALKAEGITKFAVAGFCYGARPGFDLAYTGEIDIVAVSHPSLLKIPEDLEKYAAESKAPLLINSCTIDQQFPPEAQTQADDILGGGKFAPGYTRTYWEGCTHGFAVRGDLSDPNVKAGKEGAFKATVEFLIKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPF8</accession>
    <name>A0A2G8SPF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_02387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPF8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPF8"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF20">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="35"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="557" mass="60617" checksum="3A856744FE452680" modified="2018-01-31" version="1">MAGGAPVVAASNRRKNLAGPSGWAGLLANARIFAIAVFASLGGLLYGYNQGVFSGVLNMYSFDQRMASVVNDTNQKGWFVAILELGAWFGVLCTGYLADKLSRKYTIVFATIIFCIGVIVQTTAFHPDSIFAGRFVTGLGVGSLSMAVPLYNAELAPPEVRGSLVALQQLAITFGIMVSFWIDFGTNYIGGTGATQSEAAWRIALALQLVPAIVLGVGILFMPFSPRWLVNNGRDDEALQVLSRARRQAPDSDLVQIEFLEIKAQYLFEKETAALKYPDLQDGSFSSNFKLGLYDYLSLLRYKSLFYRVAVGTLTMFFQQWTGVNAILYYAPTIFQELGLTGSTNSLLATGVVGIAMFLATIPAVIWVDQAGRKPVLISGAFIMAGSHIIVAILTGLYHDSWDSHRAAGWVACAFVWIFAMAFGYSWGPCGWILVAEIWPLSVRGKGVSIAASSNWMNNFIVGQVTPTMISKIGFGTFVFFGAFSFLGGLFITFLVPETKGLTLEEMDEIFGSAGLAAGERQRLEDIEKRIGLDAYNHEDPNRASTEKRDSDLIEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQS8</accession>
    <name>A0A2G8SQS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01762</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQS8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQS8"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="260"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL36102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="472" mass="54364" checksum="F3460704E5974E41" modified="2018-01-31" version="1">MTASMQESEKKAQREWYKFESSRAAPTGFSETREQPPEPVNTSLHQLLDSVSNATDPWLLFLKAVFLCRLSRREEAIESAILSISQYPWNWSAWVALGDCLCDGDELSSMLPLLPLPASHPLVLMFQVKTLNTLNSPTDNELALCDRLLSEDFFPRSMWIMALRGNVLYYLHDFTSAEAQFRKILAIDPYRVDDIDILSNILYVTENGTALSKLAHDYLAINKDRPEICCIIGNYYSLRAEHEKAVKYFKRATQLDRTYLAAWTLMGHEYVEMKNSHAAIEAYRKAVDVNRKDYRAWYGLAQAYELLSMHQYALYYYQHATALRPYDVRIWQAQGMCYEEMGRLRDAIECLRRALIGADPEETVIHSKLAKLHNELEEYAEAAAYHRRIVEVCRAAHKPVPEWSKSAVYIARYHIQHGGGDFVLARQYLDFVATSNAEEVTQANEMLRRYQHVLRQQQNPQVRAASEGPQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRP1</accession>
    <name>A0A2G8SRP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRP1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRP1"/>
    <dbReference type="OrthoDB" id="2802734at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="283"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="848" mass="95944" checksum="B1F4F190F2F9A92E" modified="2018-01-31" version="1">MSNHPQPDPLSAAPADPPHNDDIVQHGHLTPPTTPTNPATNGIDLHHTPARPGVNAAQFGPRPPQDKDLRSLYTGVEKMQDNLHQVSLDEMFKTYLNCGGDPTAEDLKAFTYDDEGELEKVAKEADLGPMICAMGQSVADRAGETILFRDISAARPRSSNQASNSRKRKPKDGEENSEVRNDSEQNDSSQSHGTTPDVAIYLNNDRTKTLFVIKPEDYQKRAGKKAKEKAKEKEKDKTFGAHQDWVGHRSWSDIVAFFEAKIDHTLSAFEFAHPNTRFVRDDTDGGEKSLGQFLEYLAQILAHQHRTHLFAVYVFKNQARLVYADRPGAVVSEPFFYGTRDHSTLHIFFWKLARMSNKERGFDETATPASDADIRAMREYAATAPTEYLKAQAYYALSWDPTAKEGKQLKSLEWPMHKLSVGDRTVFVGRPSFATHSLFGRCTRGYVAFEKVQKEGKTSWHLHFLKDSWRVKDANNRIRPEHKVYKRLHKKGAGDRIPTSLAAGDVVDAHGLPQLTRLHDIGERRHHPRAHYRILIAEVYRPLSDFTDFRQLAELLRDALLAHKDAWEKAGVLHRDISFNNILIHEVVEDKKTVRKGILSDWDLSKYKKDVSGTEPRQPDRTGTWYFRSAVLGRYPRKPYEVSDDIESFIHVYHYSVLRFHRTNKTESLQDHISLIYERAVVRAEDGAHLGSTSKFDHMCMATSFIKPEDNRSLQLVLNQLAKIYSQHYATIDEQEYKRKYSPSFDPTKAAAARPASNEDQDSDAKFMAAFDDRTDGPSMPSANRTLEGHGKLLTAFSAVVAWDRDLPKGPIDEFKVAGIATRKNNAFSSSMPSQGPSSQDATHVHTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS40</accession>
    <name>A0A2G8SS40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_00212</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS40"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013634506" description="chitinase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="43"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL36523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="322" mass="34048" checksum="6BA48B30110A93BA" modified="2018-01-31" version="1">MVASVLRRLSAFVAVFLAFHLAAVLAAPVEEHGLQARAAPAAPHFVVYADAYQPGVTGPPAVSAVTGFNVFILSFWLTAGPWDKAYEWTTLSASDRATIKSQYNAAGIKLMVAAFGSSDVPTSAGADPVTIANNLASYVKTYGLDGVDVDYEDFNAMDGGTAEAWLISFTTQLRAQLPASSNYIITHAPVAPWFSPTHYAAGGYLKVHQQVGSLIDWYNVQFYNQGASEYTTCSGLLTASSSTWPNTALFQIIASGVPASKLVIGKPATAADATTGYVAASTLASCISQAKNQGWNGGVMSWQYPHADASWISTVRSQAWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSF8</accession>
    <name>A0A2G8SSF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSF8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSF8"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="277" mass="30343" checksum="1AA36470ECD8FD56" modified="2018-01-31" version="1">MFRNTYDSDNTVFSPQGRLHQVEYALEAVKQGSAAVGLRSKTHAILLALKRSFGELASYQQKMYRIDDHVGIAIAGLTSDARVLSNFMRQQAMSSRMLFNRPAPVNRLVAAIADKAQVNTQEYGRRPYGVGLLVIGQDKQGPHLYEFSPSGNSYEYYAMSIGARSQSAKTYLEKHYESFADCTLEELIRHGLHALRETLQQDKELTINNTSIGIIGAGGAHETDVGTEGNFRILEGEIIEVYLQSMTPKETADALAHAPAAAPADAGAGDEDVQMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSX8</accession>
    <name>A0A2G8SSX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HBS1-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00567</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSX8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSX8"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HBS1-like protein N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="680"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="760"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="781" mass="83915" checksum="7808652D86CD4565" modified="2018-01-31" version="1">MSRHRYVRNIDINEEMEDDVVSDGGYDDLSPEDHERMMNGLEHIRNMIGDAEASKLSDEDIAEALYHFYFDVEQATAWLLEEQERRLAAQARKDIWYTEDGKVLPMAPPDDFADWSPPTDDASGRHNVPFVRLTSNEYVSPPEQGTPILSTRPGTLYTITELTEHSEVTRNGDYLSVHGSTAGSSTITDYGQILTRPTLHGTRGNALSPTSPLPNDPSRIPLSPSSSAEQRLSLDLGSPTGPPLLNYSDPSSDNDSSRPPTVVDFPSMDNMPDIPDWISKSTLRPQQGGLSSASLLTRSMKPSEDTTSQMSMKSERSAKSAHSAQSGKSEKKSKLSTLASSRSSARSGARSSVSSISSSQSSVPETEATLSTSVTYPKLRPAATSFVSLLPAQARPPSTLSTDSTSPSSLTRNVEQAIQSALALEAMDRRAQQEPSLRQSTIPPTPPPKSPPRTRSKTPSETQEDVAPRASPIPLPLPRKASVGSSAPPSVAQSPPPVAQFPPLAPRTPPSSPPRTQTAPSTSPQPRQLSKLAKLAQAKAQEQGKSKSQSSHTHLGLALPRTTTEYLMPTANGPTATTAITTSYQSLSGLLSKHQVKLPPSQPTVAPLPRVPSTGSAKSSEPRQSKLAMKSKTSRTKTSTEPEPEPEEAPVVEVPMFSPSAIRTRALPSAFATLLVSDEHDGASNHGSEGTYLCQHHKAQRERRQSSDRSRASDDDARPRSTRSGRVDSVLPLPPTMPSLRGFAFDVPSPDDIVYNARKGTSLAQRSTSSTASSALSAAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST14</accession>
    <name>A0A2G8ST14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_00562</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST14"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST14"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL36872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="402" mass="43464" checksum="A156906AAEE2C38E" modified="2018-01-31" version="1">MRTKHTSHPLSSFPVYSCAFVSANEFVLGGGGGQSKTGIKNKLRLYHVEGDSKLTLLDELELASGEDAPMSMAAHPSRSEIVGGINSSEDALKSGLNQNCRVFDIKDSKLSFTQAQSTIHLTAEDDDFQKVTVFSPNGKYLAVGGTRDLSVLDYPSLDPIATPIHLEKGEIYDAAFSSKTLVVATTVNLLVYALPSEEEGEATEKSKGTPPVPLELLHTIDRPALPGKDAGSSYRAVRFHPCDEKVLYSVSNTVPPKTRSKASPRRAYVVKWDTDTWKTTKLRQISERGVTCFDVSPDGKLLAFGSSDLNVGVLDAQSLAPLLTILKAHEFPPTTLRFSPSSDTLVSGSADNTVRVVTIPIGLGATSWGSWLLFIVALLVVLFAILAQQWFRGITDVLSDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST60</accession>
    <name>A0A2G8ST60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST60"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST60"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058268">
        <property type="entry name" value="DUF7962"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25907">
        <property type="entry name" value="DUF7962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="1">
        <location>
            <begin position="66"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="305" mass="33823" checksum="B3E4B8DFA6ADE478" modified="2018-01-31" version="1">MPMTLPRPDLADRLGVKYRRIPVLAIGKDVYCDSSLIASVLERNFTPEQGFGTIFPKRKGGGTADTGMIKAFAMSYADRALGTLGSQTLPYHKFKPEFLDDRSNWFGAEVDPQAMIANQPVAISSLSSHLALIEEQLSDNREWLMDTETPSLADISVHYIWDWMQSFRPLKDIKQELLDDTKFPATLAWIARMSAFIAKEDAAHPAILDNISGERAAELITSSVSAELNAVNFDEIEASRLKVKLRELVSVEPIDNGKIPTVGKLLALNREEVVVETVGSSGKPVYCHFPRLYYSARAGVYTANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST63</accession>
    <name>A0A2G8ST63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_00659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST63"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST63"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="76"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="224" mass="24353" checksum="CA507C29C000557F" modified="2018-01-31" version="1">MKHILFVFTSANKNLTGGQTGYYLPEAAHPYYVLSEKYHLDFASPKGPNPPVDEYSVKTFPDDVPKFLENPTVQRKLASTKRLADVKAADYDAIFYIGGHGPVLDLPQDPTNIELANEFWRAGKLTTAVCHGPAALVNVTDARGQSIFKGRRATAFADEEEELMDAVQAVPFLVEDRIKELGGIYEKAAEPFDPDVVVDGMLITGQNPASAKGVALAIDQALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STC3</accession>
    <name>A0A2G8STC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STC3"/>
    <dbReference type="STRING" id="1077348.A0A2G8STC3"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013728659" evidence="7">
        <location>
            <begin position="20"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="762"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="825" mass="92931" checksum="91D1E2944907C957" modified="2018-01-31" version="1">MRLFRSAIALGVFALSAFAQEEHQKHAYQSDVARLRKIVINSLYSHRDVFLREIISNANDALEKLRLSSLTEPDVLTGAEQMNITIKAVKDGESAGRLIITDTGIGMTPEELKNNLGTLAKSGTSEFLSRAESDDSSGNGNLIGAFGLGFYSRHVSFLCNIFLVADRVEVASLAARTSKNPAPAQYVFSSGADENSFDIYVDPRGNTLGRGTEITLFLKGDAVNYLNEQTITDLVNKHSSFSTTFPIYLASKRTEFVLDEEANEEPAHEEKKSQVEETPKADVDEDEAVIEDVIEKEEKVKKSPKTKQIQVDEWLRLNSQTPIWMRDPKTVSDEEYETFYQATFKDYEKPRAWTHFQGDSGSGVSFRAIIFVPSRLDDDYWQNPLQSVTKDIRLMVKRVFITSDLGEDALPKWANWVKVVVDAEDLPLNVSRETLQNNAFLKQLRGIILRRLLQLLARLQEEDAEKWAHIEETFGNVFKLGAVEDRKNRDKLVNLVRFATNQRNSTSLDQYLENKKQGQDKIFYLADMGKSAHELAGSVFIEKLHARGYEVLLLSDPLDEVFITNVRRWKTIGFQDVAKTGLKFGDEVWLSNLMLYAETDPEEEKAERATLTEKFEPLIDWLRKEVREKGAARDVIISNRLVISSCAIVADESGYTANLEKLISSSHAQVNHKHMWDFAKKQKVLEINPRSPLIEGLLRRIKQLPAEGEEPDVEAEAELREVATVLVDGALVRSGFSVTDSNDFFTLVDRILRRSLGVSETAPTDTTVKPAPPVDPELPANANEPEPDPIVKSGRGKISWEVEEVDELGNPIKQVPVEMKKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU54</accession>
    <name>A0A2G8SU54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cystathionine gamma-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU54"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU54"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43601" checksum="C4671EEEF74C7416" modified="2018-01-31" version="1">MAPKDTNKLTGTQLIHTDDELHGPEVAPSISVSTTFRATDPTKFPKEEFDQWNPKHHVYSRYTQNVSTRAERVLSKINGGYAVTYASGLAASYAALVYFNPKRVAITAGYHGCHATIDVYKRSRQGNLPIIAIDDDFQPGDLCWLETPLNPTGEARDIKYYADKVHKAGGWLIVDATFGPPPLQYPFKWGADIVMHSGTKYFGGHSDLLCGVLVAPTLEKWKELWHIRTFLGSMMGSLESWLLLRSLRTLHLRVPRQSENATGLAQWLSKAAGGKTHDGIPAGVIEKVWHSSLQGVDARGFDPATQLEGGHPATFALFTTKEQYAALLPHTVKYFIPATSLGGVESLMEQRVHSDPGADPRLIRISVGVEDLEDLKDDLRKAFQEIVKATRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUH6</accession>
    <name>A0A2G8SUH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_01120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUH6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUH6"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="8">
        <location>
            <begin position="41"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL37426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="879" mass="94225" checksum="74FB118EEF977DC9" modified="2018-01-31" version="1">MGHPSQCVHPLCPLAEVVLTDTLAHLRARAVVIIGMTQILALFLGRIRQPRVIAEVIGGVILGPSVMGRIPGFTTTIFPTASMPVLNLTANLGLVLFMFIVGMEIDTRVLRRNARASSAISIAGLILPLGLGAAIAVPIYHQFTDGTANFGYFILFVAVAVGITAFPVLCRILTELKLLDTTVGVVTLSAGVGNDVVGWVLLALVVALINASTGLTALWVLLAGLGFVIFILFPIRWAYYWLARKSGCLDAGSPSAMMMTVTILTVLVSAFYTDVIGIHAIFGAFLAGLIIPHENGYEISLVEKLEDLLSILLLPLYFALSGLRTNLGLLNNGITWGYTILICVVSFSTKFIGCGVTAKLMGFNLRESGAIGTLMSCKGLVELIVLNVGLTANILDTRTFSMFVLHALVLTFITTPLTLLFYPAKYRVHAGELPKRPAPSIEDGAGSTQKEIQDALKSRFAIVVDRIEQLPAVMTLTQLLQSPSATLATPSGVSSVDEKGALAEVVPRSRTSATIPRIKVDALRLIELTNRTSAVLRSQAADSLALSDPVLAIFKTFGYLHRMAVTTALAVVGYENFSDNVNQHVRASGSQMVILPWTSGLGAVEDAAENPTPLVSDVASPSSGTNASPFDALFQVKREKEKSQGSVATHSHFIRRVFADTPADVALFWDRGVRESEGEGRYHIFMPFFGGPDDRSALTFVVQLCMHPSVSATVVRMKKAEGAELEPADTIEQIKGHNAVHSTLFPDTVYGAQTTQTRMASQTADDLLWTKLTSSGVPELANAFARLTFREETAAHPLHHVLEVAASTARANTRQIIVAGRSRRMAVESHEVELQKLVGERGATLGAELPKTLGEVACAFVVAGSAQANLLVIQAAQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUN5</accession>
    <name>A0A2G8SUN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUN5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="239" mass="25514" checksum="A4DC8B41D9B000B4" modified="2018-01-31" version="1">MLARSCAKNHDDARMDPAHRSQPAASAACCRKPSSNTAPLPGLTLSSSRARSFHSPHHRGGASSCSRRPLHCMHLTSSVMHNSAIAARARRSCSRTRRWYAYADMALRSSCRGRLWSPVDSVACAARRASSSSSKRLAIAYTRRGEILRKVGSTRRLRSPSVAAVRSNFRAASSAGTSSSSVSMTGSGTGYMYVSKVSRTSAVSVKGMTGIVVSSLSCVGWGRDNMASKKGEAVDRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUS8</accession>
    <name>A0A2G8SUS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUS8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUS8"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="167"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL37510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="630" mass="71198" checksum="7D308B08D92E7C12" modified="2018-01-31" version="1">MEVPSSDLRNRRYLTQLMEAEQVARQYSGDDFTSDGYNAPQMEEYHSHLAHLYPDAGTSSYQYVSPAGNMVLENLEILGAVGDDERPMKVEQVDDEMLFSDENSGDEDMDNDAEGDDPESEEDEEEETGDETDEELTIYLKSHEERAEIEEEIIDLEAAVPALVEDYKIVDRLGTGTFSAVYKAIDLGYHNKWDNSEWHGRHPSTSSAYYQTIRHPPQTKDQVVVIMPYHKNDDFRDFYKHIPIDGIRAYFRCMFRALRDIHARGIIHRDVKPANFLFDPRTGVGTLCDFGLACRMERGLALGACLHTTPSKDSPHGKLKSRSEFNCDIEFIKQMQKEGRMKSGASSERVGYPTKDARPHSKANRAGTRGFRAPEVLLKCGEQSGAIDVWSAGMILLFFLTKKFPIFNSNDDTEALIEIATIIGRRKMEKTATLHSRLFQSNIPSLSQEGMSWKEFVERQNPELRTPPPPDPIFYPYTLPGRHPRMPPPPSSSSGYSPAASSSPEREYSPTPSDIDKHSTDVDAALNFLEQLLQPESIRRITPRAALYHPFLRDPDMPEDDESVPHPFLIGSCADLHFMDDAGDSYVRVKVDASDADGDRDEWVVRKVRAGEGLAIGRTPCEFHRDVSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SW15</accession>
    <name>A0A2G8SW15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SW15"/>
    <dbReference type="STRING" id="1077348.A0A2G8SW15"/>
    <dbReference type="OrthoDB" id="2758715at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="636" mass="68439" checksum="51C902E8ED804904" modified="2018-01-31" version="1">MNRASASDRSRSNRKRSKNDSPNSVSPPPPLPIPSPPIEPPALTQAYATLPSGIPEPPNTPPPLAQAYPTLPPPIAPGFPQQTLSARESSRSSRSTPEATYYSPVSYAHSSLAPVPTSSHPQYHHEEVAYPPSSQGSRASSFGRPGDDPRWPYPSQGEQSYPASESDRYSPVSPATNSNGHYQEPASPVESLHGHHRAHSQVQGHGHVQMSPQDPVSYYNHHYQQPAARQQPQPNAAGATSASPVSVSLSLSLSQSQSQPPSTSSSHRHSIAHISNPIRQHSPTSTNSASPVVSTPPTPGYGYVSQMGAYAESPPGSLSPVTPGPPPPQQQQQQHVVPVYNSYESSSLASAGYSHPPPAQVPPQQQQPQQQQQQQQMYDRTLPALTATHAREPQAPPPSMHAQTHFTYTQQAAYPLPPPPPGSSSASSSMGVGDRYSSERPVLAPLVGSRVMRGDPAGSATAGGVLRYPSPQPQPQQQQQQPQQQQQQQQQSLAGRHAFSYTPHPQQMSPQSEPPYGSAGGYSPQTHNQHQGHAPSEEYYYHHHQQLPTHAHGHTHGQGQGQREPSPEDAAGQEQYLELHQPQPRSHQYIQTQTGVGMHGHGHGHGHGHGHGHGHGHGHAAHPHPVWRGVEGRLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM73</accession>
    <name>A0A2G8RM73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_15290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM73"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM73"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="144"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="298" mass="31117" checksum="AA8BD579996F9B41" modified="2018-01-31" version="1">MLSGIGDVTDLKPMGIKPIVDLPAVGKNLHDHAFLGNSWLANSNNTLDNLHRNNTLAAEALALWQINGTGPLVLGGSSQFGWLRIPQATDFFQSFGISDPSPGLTSAHFELLAINNFISKTVALPTEGHFFSIITVVISPTAPSPGGNVTLNSTNPFDAPIINPNLLGSPVDLAIMRDAVKAARAFVTAPTWSDYIISEFGAFANATTEEALDAYIRSNSDTIDHPVGTVAMGNGVEGALDSHLRVRGTVGLRVVDASAFPFIPSAHTQGPTYILAERAAYLVMTGSGDGATVGGPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP70</accession>
    <name>A0A2G8RP70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP70"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP70"/>
    <dbReference type="OrthoDB" id="1106148at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055304">
        <property type="entry name" value="CHCHD2/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523:SF2">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13523">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 2/NUR77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20031" checksum="3C8A624BA0F215E0" modified="2018-01-31" version="1">MRRGPRTWPFGKDLCASLSDETSSAHLACVPPPAFFPSPIQLPSSTAMPRSSRSSRPAARPAPAPAPQQTRSAHTAAAPHPGTAPHPSQAPPVPPQAQATQSSGPGMLAQMAATAGSVAVGSTIGHGLSNMLFGSASAPAAPEAPAAPVQQQHQQGISCDFQAKEFTKCLESADVNACSWYLEQLKACQAAAARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPG1</accession>
    <name>A0A2G8RPG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPG1"/>
    <dbReference type="OrthoDB" id="10591040at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="473" mass="51380" checksum="34EDE22A26E7909E" modified="2018-01-31" version="1">MGNDDVVSLVQSDNFIIVTSSLLTGQIAARACTIAADMSVLVITWTRTFPEKIGGARMKLRSGIAICMLQDGTIYFGILLIIHVISLALIRELQFVNVMSQWIQAFTAVLACRFILDLHESFAAAIELRIGVPKTPDVAPSDDNTFSTWFLDHAPLILGSALSMFASNIFLYAFLNSGIRAIWHVSPHALSSPPSRIQMLAIAAPRSVCAAYAWTTQLARHIYLLFLYALCQAVILPCLIGSQLLGWAGRVWFVALCVLYTAFRILFTVAFDVLVVDPGLACLAILAAKGLTSSLRRTSDWTTDLHEAAVQFVGGTQSTLPLVHSPECSSTASPSRLGDSLVGPSRASARTIFDSASSRTKKCAVTANFVIAYEVEIAREETRFRFPVATTLHLRIALAGQREGRSNDGSASPGMIDVLQQSESDDGRHLFDRRDPGDGWLVTEAGKTPRTTGGQGTPQERISRGRESVFEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPI8</accession>
    <name>A0A2G8RPI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPI8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="15645" checksum="4E68BA08B0654B7A" modified="2018-01-31" version="1">MLYNGSMYFIIITVLDVLVLILFQDPDTVIYGNFATLFLTPATMALTCRFLLDLHQANREATAPSLPSGIPTLNFAPSTDSQPTREALPAFIASMGSLVHMPELLSEENIAQRRRSGCPEEALWNEEDLEELRKATQEGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ88</accession>
    <name>A0A2G8RQ88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ88"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ88"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="164"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="761"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL23680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="820" mass="91407" checksum="4AF11A0723AF2CF1" modified="2018-01-31" version="1">MEQPIVSANPTPPAKTPVARGARACTVCRAAKMKCVGAEDGTKRCQRCQRSGVDCVFEKHRRGRKPGSKLSEASKMLRRLEKGLNNAKAKQPSNTPLPHASTSAAPYGQDDGLGSVNNGSRSGVQSDDDMEEEDEYRHDDPAIYADREIRKHMRTSFLDVVMNKEPVVEPTRPSSGSPTDRPSHYQPKAPSQSPTRSQGSPQPKPYSNLFAYAPKDPVAASIIPEADVAKYFDAFFLRLNPFINLFDPVLHSPTYVRSHSPFLFTTMLMACCKFFCPASYRSVRRLAHEWCVYTFAEGTESVETVQALACMTYWKEPADRRTWTYIGMACRMAVNLRLNRYVGHRQMNESIEQLLERRNRERTYLVLFVHDRSLSMQTGKHWMLPEDELVRHYRNWHEEGAMGQNADIRPEDVIVAAFVNLRLIGSEATDTFYNRTTAFENELDRYNMKLDEWLLFWGDQMRRSSLAHPFHSAFLEFFQSHVRLFLNTFGLNLSSLEASRAMPNSQAVRQCHQSARRNLHIVSQDFAGMHVLQYGQESITVMSAYAAIVLLKLLRSPTTLIQLKDNVEDIHVLINKTADAYQSAGHVTGSELDTAAYHARFLRRLTAIHQEQRVRQQAERNGYRPEGIPPSFAQGLPPIRTSQPPTGLQVDPYALQRPTASNALNAPHLAPLSIPGSSLNGIQGFSPGYPDYGLESAARNGLSRHSHRAASSTFVGGDSDESYFNYMLGEIPANADDLFPTGDGSPHPSMGLIGSSNGGVADFPYGPPSSSNHFRDPGLAPLQMSSAYGSGGHAHSHSRSSSYQHIPSMPSYASSSFDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ92</accession>
    <name>A0A2G8RQ92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ92"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ92"/>
    <dbReference type="OrthoDB" id="2737640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="3">
        <location>
            <begin position="138"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="511" mass="57805" checksum="32CC6B3FCF84D572" modified="2018-01-31" version="1">MGPKRAQNSSLHPNKRARTFKVRVVDTPPPVPQPGPSAGSTTYVQDTRLYQVYSLTDGRVGMRHASSKVTVTVPLPPEDTTDRRGIDSEVGSVLDSFSVEHAEALDQPSFEPHEKKKRKRPELHALRWDGQGFRRLSLRELGLTVQLGHDGDACNCPAPKLCRIAVCDITGTHQVDVCFCECLDEDMDLFTPEWVQLFRCGWFPATTNRPATVFTFCLLDFFQELNFQAKTNLYDFWKTLERVTDNTGASAPLNRYMQISHSVRLWRHLVLLKCAGHRHDPTGPEGTQQGELAIKCPACPQPGKNLPADWESAPDGMKWLYTLFLMCDVNFRAKLKDHGFDDFELGSGWSYFAETRGYQRHLEEAGDQDERNECSAEHQAILKANLRREGYLTSGVGAVLCARHVLVRKNAAGDVPNGEKFAIMDFLVFSTIVHLMLMYLISYDITCQWHKRLPICMQALPSHLQRDLEKDSVRFAIPKKHIRVHGANHSQFSLNYLPKVGRTYGEGIEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQD1</accession>
    <name>A0A2G8RQD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQD1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="197" mass="21968" checksum="58FE2DAA59C7C345" modified="2018-01-31" version="1">MRERLRPILMIASTPSYGSQATAAGMGVLDEEDWHASSSLARSASPRASHLWQHRARSSPQHRTRKVRAPQTPWCWRCPLEKGPEPVRHARSVRPSIHASGVAITKNQNWQAINIYVPLSVHLVWRRTARGVAVGDRTRLRTTLPILRPRRSPLVLRPHHASWVGSSFVATCGWVPTRSPDPEPPCAAEQPFSSVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQJ9</accession>
    <name>A0A2G8RQJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NYN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQJ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQJ9"/>
    <dbReference type="OrthoDB" id="549353at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905762">
        <property type="term" value="F:CCR4-NOT complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10910">
        <property type="entry name" value="PIN_limkain_b1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024768">
        <property type="entry name" value="Marf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379">
        <property type="entry name" value="LIMKAIN B LKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379:SF3">
        <property type="entry name" value="MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="7"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="492" mass="52985" checksum="7E3488EA2ABDF0AF" modified="2018-01-31" version="1">MVMPESVAIFWDYENCALPALEPSYTIVNKVRRLAHQYGSVKTFKAYLEYPEQLSVKSMALRSELQSCGVSLIDCPHNGRKDVADKMIMVDMMAHAIDNPAPTTIVLISGDRDFIYAVSILSLRQYRIVLLAPRAAYGGLKAQASAVHNWPDDFLPELPPSAQHCHAPQVNASSNNHPQNILKGGQIVFDRRWSSASTSSSASPAHSEAAFEPSVDGDTLGSPDDCVESGTSPRGMPGESSGGDIPALEHLQEPDGRLESTGGDVDSQELITPSLSGTSHSPSFSERQNSASLMLKPPGDQSTTPPPPSWATLVKHEYTRWGAFAQKQPSPVASDALGLETKTIRATLSSSPPRLNANASSFEPTPRSVASFGADESSGGDDSAGWQTYSRAAKKPPPQVPSEFKPLVKVLKRQLVEGVVQLESSLLGQLLSQEVTRLSLIYERAGVARLKDYTALAAERSIVTTTRESADGHNYIALHPAYRRKAAAAAWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQW9</accession>
    <name>A0A2G8RQW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQW9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQW9"/>
    <dbReference type="OrthoDB" id="25002at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="616"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="729"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="933" mass="103664" checksum="B20129DBCCB9B689" modified="2018-01-31" version="1">MPDWLSTIAGAAFAFLESSSHSQSDPEPAPELPSHPQPQPQPQPQPQTRIAIQLPRLAPPRIPIPRQCHHNLLQYARTAILPHMLLGRAAPPLPPPNNKSLRNPVFEQHEVYRHLDVMNPINDFQDLATAFTNANIPSTTIGDSDVDAPRNGRFSIPAPGYAIPQTVTGEVTTLPEIVDWVRQFPLTTARRMMHLLYPSTLNYKMQHLGTPMDRDKGIMECFKWAPDENEIMEADDLYRESVMFFVQPPWMLSSKDMDVFVCTNKFPNPWAKNRTRMQGHERLWSKIYDGCTQNHSHFFVVTTYREWVFGAFSKEHTQAWTSDVMPHDTQNPDPTIVEYLVYWLASATASEAKIVDPWIIPKIYEPIFFENDEEDRMHYDPEASLPGAPSVSAAWSAHSSARSHDPSMQDSDGESSETVMDVREDGDSDAPRTKAKRLRHGFVPSQIDDWNKSVVAQQPVVQGGWWQQQPGTPSIASSASSVSTVRDYANETKTGGTTVVIATAQCASWASRRGYTVTRPHGKRDRTRVSNHHRPVLFFPGASRSQPDHSVVTTQKSAAASSRVHRSSVAMGATGIATSSPSQWLFPVSALHNTPSRMTSDISLERELYDRSRGVEFLYRLGVSLGLPSSAMYTAATWFHRFYMRYSMEDYHRQDVAASCIFLATKTEECGRKLRDVAKVFCSKVSKMDINQIPDDSKEVEECQTSILLTEEVLLEGLCFDFVVDNPHSELVDLYEAHPNNNPQIEECAWSIANDSYRTPLCILYPPKVIAAACYVLAEHAIEGPPHSPLDARIASPAPSASLPTPPSHKAQPTGFSRHAVEFFGFNEMELASVADTLSILLEYYGAQDLQGSSEFLTALASIPPPQSTSHRPKIYRPFVQVAAATLQPTASNATPEHAISQVGTPTQPGGSTPGKFAAGGWKPVTEVAQDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRT9</accession>
    <name>A0A2G8RRT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRT9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRT9"/>
    <dbReference type="OrthoDB" id="3253553at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="59675" checksum="AAB8986E54650DFA" modified="2018-01-31" version="1">MNLYSDHWLESPPPPSRFRRPWSPDPYDPLPTSSNVRTRDHNPYQSVGQWAVERRREPSDVSVEALDLADYATTLNRNNRFNHYSSQQTQFRPYDPYPPSPRSNRPLARTDSLSPPSLTSASVSSSQSNRSPTRRPFSLPPPSSYPGYSQGSHASQASRSRHDPRIVNPESEIDIAQFPSFSRGWYTRDHANPFSPPSSPHGHGGDDGPKRNPFDPSYTLDRDPFLDPYNPSPPLSYPYGSSYGHQSRSSRDHNLVPWSTDADGRPVDPEVKEERMRMLEREFGKNAKNADAPEHTVGSVDPKGKLITEGPKKRLAVRCLQVFLALAAAISSIYSGLVIKPSPAAPPAGKLPAYILYTLSFLTFFGCTFFFLIYPSCCGARKPRDTPLTGGPPGMMVLPVAGFPGQKPKKGKKGKGPPDGNVQVNLIVDPTMFGRDPERAHEDEEDDEDDGSSAVPGSYSGASSAARRRAPRRRSIFAGLAMEEQWKKARKILKWDVTVDTVLMLVWGLEFVLILLGKRCPVGDYLGCRMLAVSTVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT45</accession>
    <name>A0A2G8RT45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_12571</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT45"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT45"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL24687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="526" mass="59561" checksum="B451F9F0ED134D31" modified="2018-01-31" version="1">MEVASPLTLPALAGLFFVASVFLYSRSLATWQSRSRRLPLPPGPKPLPIIGNMFDWPTRNQWRALRDMSTQYGDILHFKVLGQHMVVLGSPEAMFELLEKRSAHTSDRQQVPLINLTEMSVNLSVMPYGQWWRRHKRAFWQHFHPGAIPTYQPIQRSAAHRFLNKLLKTPSKLREHIRLSVTFSAAVVKVVFGLDVADDGDEIMTIVEDALEWIGETFTPGKYLIDVLPILQHVPTWFPGATVQRLIVKWRSTVVRLKEEPYRRVKAAMARNDAPDSMVSQLITDMVSDGDDLSSKEAETIIKNVATVAVEGASDTMFSTVQTIFVAMSLYPEVQKKAQAELDAVVGRNRLPEFEDRHALVYVNAVIKEAMRWHNVLPFVVPHSTIEDDEYRGYFIPAGTVLIPNISAYMHDPTVYKDPDVFRPERFIHDGKLDFSTAPDPAKFIFGFGRRICPGRYFAENGLFINVASALHVFDITPPVDEKGQVIKISPQTTDGLLCYPTDCRCTIKPRSAQAERLIQEAQLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTA4</accession>
    <name>A0A2G8RTA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTA4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTA4"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="222" mass="24472" checksum="8461C899D887536B" modified="2018-01-31" version="1">MHPRSTSASQTTVAPSPFDGSAGDVTLRSSDGVDFCCFSQILVAASSIFADMVAIGNANSDPTSSISASDRPVVPVSEDSKTLDALLRFIYPIQKQSQPRSLEDIGPLLEASLKYMMDFPASVVKEELLAFAQTRPMQIWAIGCRLMLEDAARAGAERMLHYRDLGSYTHLHQFVPIAEFIRTADARGVSAADYCRLWMYHHRRGEVEEALGANQDIFPEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTK6</accession>
    <name>A0A2G8RTK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTK6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTK6"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013890068" description="Fungal lipase-type domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="303" mass="32336" checksum="9329955ED6A990AB" modified="2018-01-31" version="1">MTCLCSWLRIATSLLAASQAIAMRHSRMKRASVTRVSQSQMDSLTPVAHYASASYCAPSSTLAWDCTDCQANPSFHPIAAGGNSFTVQYWFVGYDPSLESVVVSVQGTKPSAIIPLLTDGDIELANLDPTLFPGLDSSIQAHQGFADAHSSSAADILAAVQQGLNQYSTSKILLTGHSLGAAITLLHSIYIPLHIPGAQVTYVGFGLPRVGDQAFADYVDAHAAIAFVTHVSNKEDWIPIVPGRMLGFHHPSGEIHIQDSGEWMACPGQDNTDARCTVGDVRNLLLGSLDYHDGPYNGVHMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU87</accession>
    <name>A0A2G8RU87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU87"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="67" mass="7340" checksum="B837C69C80196C85" modified="2018-01-31" version="1">MPIIVLPELPPEPPDQKRWFVAVKALDSLVDEKEGQALDARARGRGLGSQGGRCRGGLPEQDLCRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV56</accession>
    <name>A0A2G8RV56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV56"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV56"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="300"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="841" mass="91303" checksum="5C76EC29E479BFB8" modified="2018-01-31" version="1">MPEAGGALGFHTVYGLSYVEELEGRLERMERLMNKFLPDKDIAKELDDHQSDKDPTIAPSPASERSRGGGSQVESPLNPSGLSVVPPTPGSADNAGDNEPHSDSEGSQELEKELAEGMKKLSMHSPPLRYHGKSSGLVFIRSAMAMKNENVAAPPPPKRDGPQPWLKAFVEDDFPLIESSSFPPRDLLDTLVDLYFAQMNCCLPLLHEPTFKKSLAAGEHLRNGGFGATVLLVCAIGARFTRDPRVLFDGSDDHRSAGWRWFLPVERVRRMSFVPAKIYDLQICVLMTLFLDGTNAPQGAWPVVGAGIRIALDVGAHRKTMYSPTPTVEDELWRRAFWILVLSEWLTSYGLGRPSSIHDEDFDLALPTECDDEYWLSPEGEPSFKQPPDKPSKVAAFVCVLKLCQIVAFSMRTIYSTNKASAQLGQSDEQWEQRIVADLDSALNKWSDSLPTHLRWDPEQEDAVWLTQAANLRAFHYYTQFAVHRPFISAARRESPLSFPSVIICANGARSSIEVLEVLAKRTGSAGHRNMGILFMGGIVLMTNILGLKRAGRVVNSGKDLALVGKAVEMLQSLRYETHIAEPLGDMLHELMLAVREPLPPGAPIPEEAQERTPNTPEADEAQDTEVAGQPVPDGASSASPPTASASASAASALYMPPGVDFLQPGAFTFAFPAGPGDLGFPSATQVFAGPTGGTSTQRDPLDPIPPPSALSLAYGLLPRQEFGPTSTQPQLRHNAQGVGPHQFDVEGGQMFGLEPLGYSEPMSFLPSASQVQVETADYSQQQHILANAVSMEIGESSIDAGGPGSALIDDALMVWSNLPPAMGWEEWGAYFEDTNLNAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV93</accession>
    <name>A0A2G8RV93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV93"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013943381" description="Transporter" evidence="2">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9068" checksum="2EF985C5D7AE58BB" modified="2018-01-31" version="1">MVPSAVLCLIFLLGITTLPGSSVKEDDRAHHRSSAAHAHAALHAVNGHENGGGSSRPASHLPTMNSSSVAGPQNLSVSKRLAAGVGRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVI2</accession>
    <name>A0A2G8RVI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000050">
        <property type="protein sequence ID" value="PIL25525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVI2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVI2"/>
    <dbReference type="OrthoDB" id="18440at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039258">
        <property type="entry name" value="ZNF511"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21354:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="44748" checksum="BC6C870337C37FA0" modified="2018-01-31" version="1">MASFKRARSPQQQDLSPSPSPIASPTPKLARASATPPPERSTSTSAFNHTGILCTLPPTCNPPHRPTALAGTRELEAHYAMYHAHVCEQRGCGCVFPDARLLELHQTECHDPLAAVRKERGEKIFECHLVTCARTFSTPKTRRLHLIQAHGYPKEYFFAVTNKGVGGLLKKWGEGASMLRKPWKSRENGAADAEDGDGDGVEDDAEAEDEDAMDAEGTHTDTHSAQGAAGTDGDDDDDDEDQILIEKMQIERPSGQAGSANVDSVGQGLGRKPRKGKGKEKHEPNVKASGDVDGLTNALDSLSLVPSSIQFGRGAKRGALQGGGGRGRGRRGSAIKTQEADVRAVAGTHGSVDEGAAMDVDYPPSRGGKGFARGGVRGIIPISRGGGGGTRRPARGRGRGGPPGAVLGAGAGRGMGPGRGVGKDVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVJ9</accession>
    <name>A0A2G8RVJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000050">
        <property type="protein sequence ID" value="PIL25527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVJ9"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="13243" checksum="39B9DA4585A6F821" modified="2018-01-31" version="1">MTFSSVLLRDGTIYFVVLLILNCLHLTLTLLAYNPAFQDASYLPSFTEPITAILVSRFLLDLQYANHKSVGMTCSESSTHHADSRRDGSGSVSLTFERFVGSIGTSIAPGDGDEHDIEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVM0</accession>
    <name>A0A2G8RVM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000046">
        <property type="protein sequence ID" value="PIL25561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVM0"/>
    <dbReference type="OrthoDB" id="2762455at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="449" mass="50841" checksum="91F873554F1CDFBE" modified="2018-01-31" version="1">MAMSTLSLIEYPRRVLFHYDSQLNRHLPSTQEFKKSQGGWLAPVPHDASIVISSNPRYRGTPSEAITRWASLHPMNSHFIFVTHLTVSNYGNFTTADLLAVLDAMPRLEELELCQVNILDPTGTLLVVRPAHTPVRSLKRLALEACNITEGLSDAYYDLLFRFLSLFARIERLRLLATLFRPEHLFYQPNFHPGPSLRLPTVVHLEAEGFFASVLREFCRQGDPVAGLVSLHLSRCFAEWENLYWVAGVVRAVAPTLQHLAFRPNLTASSYGCTELKELEFGLYAHGQPGYTSAYDTATTLFCCVLEALPPARLHHLAFVLDLDLDLDPGEEVSADVVPWAALDAQMNRVCVNYAWPLQVRIDRYDPDANPEARNLSLNVGRPPARRRPRTDYSDQRFWVTRLPTMRHRMAEVHDRVRSERLSVGQYAAPVGIDGQRIAMPGLRSLFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVT7</accession>
    <name>A0A2G8RVT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_11371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVT7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVT7"/>
    <dbReference type="OrthoDB" id="2268901at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013956876" description="Pectate lyase domain-containing protein" evidence="11">
        <location>
            <begin position="19"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="44081" checksum="14DBCEE21F2716CC" modified="2018-01-31" version="1">MGFKSLLASLCLLSAVSAQLSGSVGPTSSLSSKQATICNVLNYGGSIGSSDIGPAIASAFTTWVTLTGGTKWAFRLDGLITRASSTTGNMIAIQNANDFEFYSANSAGGIQGLGYEARNAGPRLIRVITSNNWSIHDLILVDSPEFHLVIQEGSNGEVYNMAIRGGNLGGSDGVDVWGTNYWIHDVEVTNRDECVTVKSPSSNILVEQIWCNQSGGSAIGSLSDGTAIEDVLYRYVYTNGGNQAFMIKSNLGSGYVRNVVFDHFISRGTAYGLDINQYWASQTPGTGAGVQLSNITFSNWDGNVVDGVARPPIQLICADGAPCSGITLTNVNMWSQTDEAVYKCESAYGSGLSCIKSGSSHTSYAIVTTSATKPSGYTTPTTLAGDLASGFATNAAIPTPTIPTTFFPGRAQITPLAKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWB8</accession>
    <name>A0A2G8RWB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWB8"/>
    <dbReference type="OrthoDB" id="2752721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39837" checksum="3EA7DA337092C58B" modified="2018-01-31" version="1">MPRLKAAFATCFSSTPGLERLSLETRFFILDLDSLPQSHPGLRSLRVFERITPHHLTFLASLPVLESLHISLSEPVKTPIRFEKLLSLSIAHDLDTAATLITSMDAPCLRNLSLNSFHPDSLSLRAELSQCLHPLVARFPSLTGFHWRCSQESDRSYGYYGSRNPNGTLAELLEPLFSLRPLRDVSLRLSGPIVPYSSTDFKRMAEAWPALETLALDLDHPDSVDLDPRYRRLVPHWTGSAPPVQQADLGAFVAFARHCPRLHTVRIPRVWMESITNVPRLLALPSESESESESGCTRMALTRHGLRLLNVHKILCPEAPQGLGSVRFNNLKNEAFRQVMGPVFPFARFQLPIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWM3</accession>
    <name>A0A2G8RWM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RWM3"/>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1511"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1770" mass="196522" checksum="CE953F3B2DEC48E1" modified="2018-01-31" version="1">MPPPTEDAQKPARQRANTTFTFPPWRRGRTETVAAPAPPAVSPPLQIDALIEALTPPAVPSLSYAKSLASALGSLGADSPPPRLPILQPILATLCSLESPIPLQTAGFDVLSAFLSGSSASLVSTADRLSCLSLFVDVQWSQELWESRTKALSALTLSGSQTVGMESQILRLVGAWIERAFDGFAQTRADTNSHEDRLARQHSVESLTALLNSLLSKSEFVSRITDEDTQMILGLWERLLDKALSMSPDFTRGSPPGSPLAEPQSSKTATPPKLSLSHRRHQSSTSLPKLSLLKQPADIIVDSYLTYLDTRLDALGPTYLSTLLPLLFRALAFYLSPLPRISIQFDPPHQHPLEEKIWDRLNQLVTGPYASSCRQLLKRQLYPSRDLQFHASAQVSVGALRTLRNSMREALLSRLARALITLSTSVDYSPAGGPAHLAVADTIMERAWGKDDTESWELIRFAHVLSRAARQWIELPEASASSVEAGPPKEAVLHEIAAIVKDVIQTIALHQEQDERGGGIEVDDEEVQAVGRITKELVVYVRSLKQLDGSPAHISLDNPDGSISFLSTMSAILSQDLKTTLLFPVLPSIILSIADHLPDRDLSQLLVTMADRQSLSPTSLTWLEHWRSILTMPDLFSPARSSTRRHAMEHLQSVWEFVKDGPAYRKPLAALVFEVWKQHPGEELEDNLVLVVWNLLADEAVLRLAEKHAADPDTEACDREDGFCEEIMNFLLEMAHEQRSEDDDDAASVLTIDSSVVSPMSLITPANPAIASPMRITTDFPSPSREKEPPSLPSITTLLSQFTSGMPTRSQSKPRRSTNDMPIQIESPVLNPIVPPVTTPRSVGAVIGLISAFSQLVFTPLALETCNIWHARRVFKHLVELVTGAGCVRARLAVLQFLMRLRVDRGHRVYFGKDEYDKDGNIATLAALIGRTEAGAPTGPGTVEELLRDDELKRTRARTVPQERDGRRASRGRGGHPRMDASRSRSRVPGRTMPSGMQKAKARDRLWMIPETLSLSVAASDVASEGLMSYDPARPSHTDSILQSSLYLTKLVEVIETEKDWEILSYVLCHLPTQLANKHLFCGPRSKKVIGRLLTCLFLGISDGSLAKQIERWPDGIISRDAQGLAFHTLTVLISYRRCFESSQPLHQLVEIFLFGLSGQPSTQKCCLHALSLSAFELESSITKYLSRIMEKLSQIMSNPAMAVHIIDFLAIVGSRPSLFVNFTENDYKMVFAVALKYLEHHNRRDGSLAISWALSQHVRIMSYYIMYVWFLAVDMPSRKRHVEYIIRQLLLSNGGKGEVDAPTEIAFDWLARYTYASADPRPAKSTLDEIVMNASVQSQRPESAISEKTWILGNSVVTIRALERRGWIEVLSRRASGLTKFLVRAENVPMVPLGDVDPDIISVSAMLMMDRENDGDNSADDGSQDTSGHAYPNLDDVKLMLSETAGSSSNIPLPDPITGYVWSRSAPSQRRKDVSIDPSYLALQLSAYPDNRPTNRGYLVTDRSKLATFFRTFDRMPVIDTHKVGVMYVAPGQEHETEILRNTHGSPAYTRFLKGLGRLINLRGQVDVYDGGLDPDTDGEYAYAWWDDIGQILFHTATLMPNGDDPNCTSKKAHIGNDYVRIVWNDSGKPYRFDTLATQFQFVNIVIEPHSRGAIAAFSNNLHEHEYFKVTVQRAPNMVEFTPIGDFKLISAANLPLLVRQLSLLSDWFVEVWRSTDGDTRPNEVVTNWGSRLAAIQRFRNQVVTVDNTPEPEDGLAAQQRLRDFTTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWM4</accession>
    <name>A0A2G8RWM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWM4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWM4"/>
    <dbReference type="OrthoDB" id="3215163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="419" mass="45067" checksum="1459BE3A5EDF8963" modified="2018-01-31" version="1">MAEQQQPAAVAAYDRASPAKKRKLMHAPEGFEVIKSCSAKAPARKFASAFNDPKRSKMTPKDSALRLKGPSKPAAFQSPSAGPSKRPSLRVLYPPTLLPDPPQAGPSKVPPAPPPPGKSVAVRPMKPPSFPSTSSSASKFTLKNHIPVLAPKKSLVAKPKASIQEFRPPPPPPAVPPKTGRSISAIQPLPPPLPRKGPPLPDASKLKTISTTRVALATDPRTESGTSEILALQLGQAVSSYIPPAQRELNRGLGQSPEKASKAKSAKYIRGGLADRTQRLFAQQNTRLALWYKDMELQVQRPEAHTPVAPDLCLRIFEVAHVTSIASLQRSQNVPRLSIVKCAKIVGGRTTGDLTVLLDFGFPGSASAKAHTLDEVKEGRDLQIWAPWNSSDSGAEELRRFGALPRDGTTLFCTRFRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWP4</accession>
    <name>A0A2G8RWP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWP4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWP4"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF42">
        <property type="entry name" value="ZINC FINGER, CCHC-TYPE, RETROTRANSPOSON GAG DOMAIN, ASPARTIC PEPTIDASE DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="293" mass="32160" checksum="513D69BA972C68E9" modified="2018-01-31" version="1">MPSSTMSNAGTTPAPLQLPAGYDVSKLVTQLAPREYNGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLTSGTQLWADFTAFETAFKAHFCAADDKEAAITVLIKLCKAQHKIGTMQDYTVKFNAIAAHTSFSAEDKRERYRTGLPYKIKDILATSGHNTSSITKIQVVTLTMDQNLLVREEEWPKQFSGGWRKKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSGEMTDLAALRAELKEIKERLSAISVNETKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWY7</accession>
    <name>A0A2G8RWY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWY7"/>
    <dbReference type="OrthoDB" id="2737054at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="41985" checksum="826AE6762B2D04BD" modified="2018-01-31" version="1">MADTASLLDKLLDSCPFLEKIDFDPGSEPNTALSLTQELARFPRLRQVNVSSCWGLEAFRVLATKPSLHRLGIPTIIGPWNGPSEVVSVRDLRELSVGGDAPSLSCLFSLARFYALKSANIYLDSADAEMSLTVTDITGLLALFYNAVSTSGLESFEFAPWPHRYEAPFDVKPPLRELVAPILPIRSLRSFTLTSKYPVASLDDTDIEALTNAWPGLQHFSAGRGPFTSGSSVSFHALHHLHKRCKGLFELSLPRICWPTIGIDVIPTPLDNGSPTHPLQELSLPPQVVRKTDLPLPGSGAELSDEGAEAMACYLFALFPRLDLDRCKRVWDESRPREMRFGTNSATRRALGPKDLHCDDRWWRVTGHMYSLCRARDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX33</accession>
    <name>A0A2G8RX33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX33"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX33"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19180">
        <property type="entry name" value="SET_SpSET10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044432">
        <property type="entry name" value="Set10/Efm1_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47503" checksum="389B95D885AC5B11" modified="2018-01-31" version="1">MSRSEHASVVEFKSWLVQNGGRIHPEVHFEPGLAGFNVVARNDISANQSIVSIPFSLAITPEVARQALKELLGHEQPSLNERQLECTYMVLHWIVRPLNSDVLKHDPYLITLPSPDKLRTPLHFTDLELAAFRGSNLFGATLDRKRQWEAEWQQCREAVASANADWGTEFTWERYLSAATYLSSRAFPSTVLSETPSLVTTDTSYPVLLPGIDALNHARAHPVSWVVSAPSAPQTPSSSPPAPEPSISLVIHTATSHGAELLNNYGPKPNAELILGYGFSLPDNPDDTIVLKIGGPSTAASSSSSSMGWEVGRNARGAEPVWEAVLSAVRAQNAEDGEDGVEEEGDAAVEDELCAADMLAEMAQGLHGRLPPFPSDSEASAAIRPEVLRMLEHYLEGQRDILQNLVAFAQEKEAGALQRAKELGLDVVEEEEEEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXJ2</accession>
    <name>A0A2G8RXJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXJ2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573931" description="Transporter" evidence="2">
        <location>
            <begin position="25"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8320" checksum="8078A30CDBB0AF20" modified="2018-01-31" version="1">MAIHPILAFCLWITINTVFRRGRGALPVDDPDAMQVDPVQPAQGKEDNDYMDVDVYSQGTEDFMALDDEDTVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY19</accession>
    <name>A0A2G8RY19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY19"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY19"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="167" mass="18824" checksum="B712A8FE5F0A1181" modified="2018-01-31" version="1">MSGVPELNPRDVGTEVPVSPEVAREAYTWNFWLCSRLEVERRRLPVMFQVPMRDQLQTNVFKATVELAKYILAGRALFSHPLELRSTFVPTRLLNKHSALVVADPSDLDASVPNRPNIEFMHIPSNVSDVDLPDKGIFSFNTVLICPESSGTMQTCNPRIPPPPRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY26</accession>
    <name>A0A2G8RY26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY26"/>
    <dbReference type="OrthoDB" id="2756044at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="327" mass="36682" checksum="3B1F13E44EAF21D5" modified="2018-01-31" version="1">MNSTVSNASSLPLGFPIGLVPLPLVQEEVKWLVLITTYTAFLVPIAAVLFFFSTPQLRGRPVFILNVNTVFLNLQATPRTAIASICLFICVPFFVQGILILRVRAVYPLNTLSRTRLVAIYGPIALFKLARIANMAYLIFRFRQAINDAGGLSTNTIFTVSQAVWTFPSTKAEWFLQLFDDMYVSTLFIARLRKPAGVQGKSARPTSQYQGTYIQRLKTLFWTAVFNFVFPIIFNIALIILLFHEPDFLHGSYIIYTNNYAQIIGVLLATVFVAGRQDESKDESPVDDLRQNRSEGSTYATRIALQNLGSNKSHLQPVDITKVERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYL5</accession>
    <name>A0A2G8RYL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000044">
        <property type="protein sequence ID" value="PIL26619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYL5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYL5"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF42">
        <property type="entry name" value="ZINC FINGER, CCHC-TYPE, RETROTRANSPOSON GAG DOMAIN, ASPARTIC PEPTIDASE DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="31457" checksum="5BE55480DB14488C" modified="2018-01-31" version="1">MSNAGTTPAPPQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFISAASIYHSNITTFLPSFPEMILWITLLNKLTEGAAELAGPHIVMLASGTQLWADFADFETAFKAHFCAADDKEAAIAELVKLCKGQHKIGTVQDYTVKFNAIAARTSFSAEDKRERYRAGLPYKIKDILATSGHDTSLITKIQAVALTMDQNLLVCEEERPKQFSGGWRKKSEKAAATGKKPFTGNCFNCGKPGHCSFECKLPKKEQQAASSSGKTTDLAVLRAELKEIKERLSAVSVNEMKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYM5</accession>
    <name>A0A2G8RYM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000043">
        <property type="protein sequence ID" value="PIL26629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYM5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYM5"/>
    <dbReference type="OrthoDB" id="2773795at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44084" checksum="FCED3F2E6B3E1D3A" modified="2018-01-31" version="1">MDVENSRSLPLHIPTEICENIIDMLYSLETEDTLKNISTLHSCALVCRAWRVRSQRTLFYLVQLTDTTSFRRLSKILDDSRHLRDYVYQVELTGHYLHSTTSIFATFPAVFAGKLPNLFRIEVVHFPDTEETPFPRTSDSPKARALPYVPLHPRFSAFLSAFTAVSVLYLQDTTFRTFSEFARMINALPNLEELACDSIRWIAPGGSHPGADFMKQPEWAAGKDTLPPFAPKLRKLGLYDVAIYGAKRLIWTRGPHLAQLYLTIPLSSSPEEPADEILRGLGTITEAWLETIDAPPLSGEIRDHQQVKYTLEVDMYEWEAEMRWWLDHLEGCFPNWVKSGRLELTLPSPRGVYDEWADEKQSSLSGAVAPSKLEEVDFGSLSKLSECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ31</accession>
    <name>A0A2G8RZ31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="11">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="primary">PSD2</name>
        <name evidence="13" type="ORF">GSI_11106</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="11">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endosome membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ31"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ31"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023313308" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023313309" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="11">
        <location>
            <begin position="383"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="11">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="11">
        <location>
            <begin position="382"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="11">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL26770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="49270" checksum="38A082015F7C129A" modified="2018-01-31" version="1">MPSSTPSTSARTPYSASSSDAEDSSNGSNGSSGSSGSPESSLERVINVKNCPLCHRPRLNAKAEVDIVTHLAVCASQDWARVDKIVVGNYVTANQAQRKWYTKVISKVSAGDYKLGANSANIIVQNRLTGQLEEEKMQVYVRLGIRLLYKGWKSRMEGARARRLLKSLSIKQGLKYDAPESARDIPAFIAFHNLNIDEVRDPLDSFKTFNEFFYRKLKPDARPVESPDDPYRLVSGADCRLMAFATVSEATRLWIKGREFSVGRLLGETYRHEAEKYIGGALCIFRLAPQDYHRFHVPVDGTIGPMTYITGEYYTVNPQAIRTALDVYGENVRKIVPIDSPEFGRVMCVCIGAMMVGSIETTVKEGDFVRRGDEFGYFAFGGSTIVVLFEKGVVEWDEDLLINSRACLETLVRVGMGLGRSQRKAITDGNVNANANASVNASVNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZD8</accession>
    <name>A0A2G8RZD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000041">
        <property type="protein sequence ID" value="PIL26678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZD8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="274" mass="29418" checksum="45229D106D89970D" modified="2018-01-31" version="1">MSPPHTSGRCVALAPTPAHNTPARHPSALRASASVSHAYLAVEGAGSRLPGRTGTSGTPRTPCRITPRANFARTATADTPPWCRTLPGRRRTLGAASPRGRAQAPSKPSSVRPRPTLRSAQPSSTTSCLPKTPSRPCRRPPCQREEGSRTIVVSATTDTFPSSWRRRRAARSTWGRCASSTMARSSWKASKWGGTAPRFHEFVHVCGLILAFPLPLTLCVFVSALLFRCILYVVSVTQVSDSECNVYCTVLSFLVATSIHGFAILILPVISAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZQ8</accession>
    <name>A0A2G8RZQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_10112</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZQ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZQ8"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="15"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL26974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="500" mass="55540" checksum="2247F111E910B4B8" modified="2018-01-31" version="1">MAETQKLRMPTVAGFKIFKQIGGGGFSTVYQAVHPESHRVAACKVVTITPDFSDWQMKSMEKECRVHTALKHRHILELIGAAKLTIDQAKRGGYLPAWYLLMEMAAGGDLFDKIVPDVGINEDVAHFYFCQMLAGLMYLHTEGVCHRDLKPENLLLDAAGTLKISDFGLCAVYKIAENGKVKMRMLSERCGSLPYIAPELRGTDSYEAPPIDVWGSGVILFTLLAGNTPWDEPTRGSVEFNQYVTGEAFNHRPWNRFSPEALSLITGMLDLEPSHRMTLSDVAAHPWVIRPSQLASRGPTAIAESLTEGLRSSGHMSIAEPSLSASSDSSGDTVMDDDRAPPHPAQSQFTQTLMLFSQVQGGARYRYSPHLTRFFAALLPRALLPLVQEALGDMGVKQNPPKELLVQDGEGEGEGRGRGEEEGEGEEEVPMIRMRIGTKDRRKIHMKGYVEIEEMKLVGYKGSFVVFARDTGNPLEWRAMWKTLVEHPLISPHVYRKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZZ0</accession>
    <name>A0A2G8RZZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZZ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZZ0"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1145" mass="125802" checksum="9EFB4FE0B5950463" modified="2018-01-31" version="1">MYLDSESRSTLVTHSQKLASYSTIEAWRSSPYGTTIRMGTKHTFDQLRRYWELYADFYDPSKSQRFQFLQKAMERKRNTVLREHGYAVHFSSSRSSGPFIAEPPVVMLVSEQFEQYWKTGTTFTDTGLVKASTHPNATFFHLRADEGFDVHYSTDPMVPFHHAPLFVDPSRTVTIKDLVESAKSEFREWCSAFRSAAATTKADKAALVVRFLLGDPLAVSRALQVLPLNDTARTKRTHIEQWTACTVDLDRVEYADHAAPVRFDVVDTAKLSDDVGMHNVFLCAAPLLNGSPAAVLYTESLLARKADPLADFQAKLFADLSVIALLLDLAPVDALSGFTTRCNTHELSMAQMTMPVAMSLDKQQCHQVLAWKRPTSGDTSASPLGIVCPPLSFDVQDFARLLHKIYLHLFEHEDPGYVKTHSYRANPALVKEWASSWCPSRESFVMLLALIGARARIQDTQWSALMAAFLDIQSDDALGRRPFDALSHHEIHAQLYRYGLHTVPELDQPSSPAAGRLSHWPLVPPLVRIFLTVPRTNLAKLKSVSEKLPAPWLHCTVKLPRSGTEHTFQSVDAFYGTVVNSTTAATDISIVEDTDAPTAVFSFVVPGSVLADRFKSDSEPRDSGVPLVRLAARATPMATKILTPVLGKDLTIFAASLDDADHVHLAPEQQLSPKPFEQIVPTENDSTRGSNLNTSSITAIGVQSLVHATLDVAGTRERVTSLTARLDIEDAEAKGSVEEGATPHISQVSPCAMRVAFGSLAQTLVYPLPVVGSQRRVRIARKSSYIEVVVPVGIPFLQPDGYKMDPFPVVHVGQALAAWNLHRVPLERLPVLNITPSNAAAVAKWYNPHVVSQMSARESAFTLRVPKQRDTVDSDVLASIKDTIYSIMVHSASPSTQARGAVFALHEGSEASTSPGMLLFVDKLRLDVAAHTVVCDAFVLPLLGSPDCMRAIRPLLVQLLASDRPQGVTNIRMHGGETEMRVWRLLLPALVERCRTSWTHGANCECAATGKIPLELERDGGGDPLCSCGRGKDVDGMLMSKEELWKGFAPFVTRVALSPLFAVSYVDPVLGGREDDDDLPAQVGAPASRPGRKARSAGGTAEVARCDRCRKEESSAVKLLRCSGCRTVSYCSEACQKSDWKAHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0J9</accession>
    <name>A0A2G8S0J9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0J9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0J9"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654722" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="209"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL27296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="373" mass="40420" checksum="F33164A582F54E99" modified="2018-01-31" version="1">MFRLSFLSVLTFVAAALATPSLLLEVSGPSNVYGVDSFNITTTVKNAGDEVVRLLNHPRGPLSDLPTDMFTITNRHGLSPDFVGITVKYSPSAAFASKDYHAYTVLNPGESISVQHDISDAYDFSTSGPGQYVVMMKNFNTFYYAADGKISALVGGSGHAFHTVNIAGNARSYKDRAHKHIGGFCEAWQERAIDAAIPLAEKYVTHAIESLAKNGPKGTEYKRWFGHALHGDRHTSVSGHFHTLAANNFSEYTYACNAHFCANRPGLFGYVYPNKFGTVHLCGQFFDAEVGGHNSRASTIIHEALHFAKNGAVDEHAHGEGLGRELARSHPHLAAANADNYEYFAVAAFGDGPEGDASVLLTQVHFGKHILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S138</accession>
    <name>A0A2G8S138_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S138"/>
    <dbReference type="STRING" id="1077348.A0A2G8S138"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35961" checksum="C6455830D9E6D1C3" modified="2018-01-31" version="1">MAAGTQAAPTCAMPLSENDGGGATENSKLGKGSKKPHKKTIVVAGLPVNVFSDPEIGGRAEVNANAGVVVMFLLHGRTGSARRMETYVTDIFEEIRARRAAYLGAQSGVQDLLIVTIDQRNHGKRMVDERANMGWSTDPAKNNERHAIDMYAIQTGTAQDVSFLIDFLPSYLFPRGERMISQWVCAGRSLGGHSTWIVLRNDPRVKIGIPIIGCLDYLTLISKRGKAHKLPFGPPHIPDSLVQVIKRADPVAAPYTASDDSNPFLGKKILVLSGQEDKTVPWSVAKDFVEGLNVGEQGVKEVMVEPGIGHDFSPVMVREAARFVWEHALIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1G7</accession>
    <name>A0A2G8S1G7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1G7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1G7"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="568"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="633" mass="69000" checksum="25B995CFE4F3148D" modified="2018-01-31" version="1">MHNRSLADIASNWRTRANENGITVAPGDESKFMMDDCSLSDLSTASIDESLLPAPFLSSQRRARALSHAHAPLVPVADNVQLATPNRSIRSVGILNTPPPQPGYRLRGSVTDPAHTRRRPAFEQTSELYDIDEDDYAPYPQTFSPPAHSQTLPLSLHDPFNASNMSLSAISHISEPIQFYETPQFFPPQQARKAPTSAATCSVCGLVKSSLAILKPCYHPLCSTCLTSALNIVGEKDMECAMCHAKVDDFTLCKNGPDVGITAATESKLQRIIEECAEIEEFDSGIGLLPSNFSGREIGDINLFDDDEIFMDRAQGASTPVAGSNASFTSTRSSDRVVLRIDNVPWDITPPAIAAWLKHPVERVHVLLDRKGKTMSHAFAEMVDEDAAKAALRTSQNSVLGKGKRARGVTVTRSSQEELMRALFPSWQGNFDGSRPSLAGLSNEHVISTLQRGLISETELNSLLHLIKSPDSHFLKVPSLPFFSLISVLSKFPADDDSRLFWSGNIRDSLYEMTHAAVQTLMLRIEENPLSDWAALLKQVVRAALDCRAFTSDQMCKLSDVLETAIPQATSSPPLSPRSRGSANSSRLSNRSGRGAHSPSSLPTDTLGHLAKEFGVDPLVVEALAQRLANTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S266</accession>
    <name>A0A2G8S266_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S266"/>
    <dbReference type="OrthoDB" id="2755071at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="15"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="302" mass="34097" checksum="D0FB236154762068" modified="2018-01-31" version="1">MANSDNLYLQTINEYIAMAAVTCTFLEATATLPDEVALVWPTNWSSMKFLFLANKYMALGDALFEVIGYSRMMHVSDSEDRPDIRIDDDIVILLTRTLALWGFHKYLTIFVLLAAVQVIPEAYYAVYYWVSFLGFTPRPLARSCFTGVYSQDAWPPFLLFVGVETFIIGLTLIKRFHSRNFSSSRDSRTLHTLYRDGTAFWFIVLAFSVANFVVMFIAPVELSNCMHPALCTRVFLNLRKAAAKECPTNPEFTMLTTLAFEHPAEPDAPSLHELEDIGVVADDDEEVVGDEELPGVMAFVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2F0</accession>
    <name>A0A2G8S2F0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2F0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2F0"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="316" mass="34168" checksum="181BE6435EBA1762" modified="2018-01-31" version="1">MGCSRKIRLSTALMVGGLFCMYMWHQGLVAAFLMWAKGEVRITALSRAQIAALRPYAHYASTGYCSPASTLAWDCGHNCQANPGFVPMASGGDGDLTQFWYVGFDPRFKEVIVSHQGTDTSKFLPLLTNGDFFHVPLDEELFPGVDRRVVVHGGFAATHSRSAPEVLAAVRKAIAKHKTKKVTITGHSLGAAIGLLDAIFLRLHIRGIKTRFVGFGLPRVGNMHFADYVDAQRATLSVTHINNKKDMVPIIPGRFLGFHHPSGEVHINEAGAWLACPGQDNASEECTVGDVRNIFVGSGSDHNGPYGGIEMGCSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2I8</accession>
    <name>A0A2G8S2I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000031">
        <property type="protein sequence ID" value="PIL27989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2728951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1392" mass="154714" checksum="5B050D9E4AF7EBA9" modified="2018-01-31" version="1">MATEAERKIKGELVELPKRDPRLPRIYRWQGHHLLSALFGEETGTTYLVLLDDSVEGRRLLNQYIREEEIPTTTDDGELFTKGYIRLTEGDCVITRLLHGSGEEKDDRLEGWFLPSKCIPEAYMEDIEQLQLRLLGVADDTRDAREKGGLPIEKDECQHSIRNAPRCYSQSVALQVPKKTISPVQGTSLETEDEHADSRETRRLILKVAGEVAAYSIETAAPHVASQLRTRADALKPSTSQENNGEEAYENFKLVQGSFGIKHIDKNDALLGFTNLLAASDLRGKEDPGRFYLFAFGMYVLLLGICSVAFSGRHAHGGFPPTAQPNSTPDPRSVRLVLVAYPPKAQFDAQAKFRFADTPDGELNLCREWYDPQYDNIPVAGQSQSVSMIQNGLSIMEEESYMQYLGRGLIQLLEGVRRQVPPCLDVRLDADAILAAISYQPSDEASRRVLPPWPLAPGQRSHEGAPTAEPQDLDQGTELWGTAGRKEVSDAWKTARRRVRRFFPELDDKWSKLRVAPWNPEDEGDEQQLLVDFDFDEEFEDPDADAEEPAPEQRTARPNQKRAAAPAAASEGHSKHEHSGVVFQKNMSDSLVNLSLTTPTSIAIKRKAASGDLLGEEGEQLRPSRRRRVDSPDGTPGPSGAQHHDDVPGLRRSKRIADLGPGDVDNGHAGASQTSGSVSSQGRESVTPLDSAYGDEEDALQNGDEPRPRLKHITALSEDMYNDIYHLTVEPARAGEPSPLLVAQNISAYGYTDGEVGEDEDQQPQPKRTKPTKQRARRGPSNRQPWKACLEKVLSLDGLESCRKEYQTLVEQTETARPANDIIQGQRFARRVVERSGQWKCFENEYIHLLPQMWGTLDEDGGKEAETLFEMHLARAHVLATVGVAWRWLDIDLPAMVNSYVEGGLEEVPAWLEGLEAQVREYLSGAQAATFNAADVGLNIPGAVPQFRKGLPGPVAQAQLNVKIIAEIRSILMGWLKYPTNNLSRLRGTFIRILLSKLGESAVLLLPGIHDVFSKPGAKLFGDTMSVTELRRAEPSVFDGVAAALAAMPVAQKGSPEHRLLASIGENIYKGRERIRKLLHPSLGGRHARLELDDVVLGDRVTSATKSLVSFLEDMHSVLILGNTPTTGVQIQAAQDPDFYSPFRQLAPQVLKVCRAGGFLDPMMIDREGAIASLWSWRGVFYRSLYSKLNDCRLFFRSAAEWEAHCAQLESRDPTQTGNFFCDPEAYGTASASRSPVHIRRYFQMEKEWRKLISTLPTGKTRLDYQKAFNFTQEPGRLPGVGRLTGMLVTSDLVYAGKVQMPTEEELGHLISHLSMGALSAVEQFLEVPHGMVAPTELVKDFFVRVYRGVRDGLDGEKCAQMQYDPIMFEHALCKYQRLKRVAGQSSAQPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3A9</accession>
    <name>A0A2G8S3A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3A9"/>
    <dbReference type="OrthoDB" id="2755983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="197" mass="22195" checksum="69D96687C985FBD4" modified="2018-01-31" version="1">MPARKPQALGQTLRGQYARREMMLRSHLRKSINAELACLSGRPDARMRWSLKAYIDDIFLGLGIRFAWVRYLLFANLSKHTGLDLIIHITSLWETGVIHFARVTDEEREAALRDPLSAAPGPLHLGLPEWYGRSDIKARRYRWKRNPSNLPGRYERNGPKSAKTVSSEAEAAADAEVEEAKQQLMVTAAGASVVETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S503</accession>
    <name>A0A2G8S503_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S503"/>
    <dbReference type="OrthoDB" id="2748713at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19598" checksum="577E6894B32B121B" modified="2018-01-31" version="1">MPMDNSVLGLFQPNPRTRPPLDFDVLSTIWAHVTEYPDLLSLSLTSSVFRPLAIRTMLRARPVVLRKIATILKFHDFVFSDPDARMPHIVAVVIHVTDYEYDTDPDCSEPAIQALLAILKRARCLVSLELSSSVNGSPLGYLDDPRLSAAVGELVSLRDLTICGRTQVADWQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5W3</accession>
    <name>A0A2G8S5W3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_09175</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5W3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5W3"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000016">
        <property type="entry name" value="NADH dehydrogenase (Quinone), G subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="13">
        <location>
            <begin position="66"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="15">
        <location>
            <begin position="144"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="283"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL29127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="771" mass="83244" checksum="C83995C118A663EA" modified="2018-01-31" version="1">MLRLVSSASRPTSAGVLAKVAATPSSTRPGTTSESYASAAPGIKHPFHGCHIAGRRTFASSSARQADITLTVDGKEVTVPQGSALIQACEAAGATIPRFCYHDRLAIAGNCRMCLVEVERSPKPVASCAMPAMPGAKVWTNTPLVHEAREGVMEFLLSNHPLDCPICDQGGECDLQDQSMRYGRDRTRFHEIAGKRAVEDKDLGPLVKTSMNRCIQCTRCVRFANEVAGVEEFGTSGRGNDMQIGTYVAKTMNSELSGNVVDLCPVGALTSKPYAYQARPWELKTTDSVDVMDAVGSNIRVDSRGVVVMRVQPRPNDDVNEEWISDKTRYAYDGLRFQRLTVPLVKQGDRFVTASWEDALTAIAEGLKKTGAKGDEIKAIAGDFADTESLVALKDFINRLGSDNTALDGINGHAAPVHAVDVRSNYLFNSTIPGVEQADAILLVGTNPRHEAAVLNSRIRKSWLHTTLEVGLIGERVDTTYGYEYLGSNAAAVAEFVAGKGEFAKKFQAAKRPLIVVGSSLVEHADGGAIYNALAKFVEANKERLVTPEWNGFSVLQRAASRSAAYDIGFVPSKKASTTKAKFIYLLNADDVNPKEIPEDAFVVYQGHHGDLGAQFADVVLPGSAYTEKGVTWVNTEGRSQVGRAAVPPPGASREDWKIIRAVSEVIGEPLPYDDVLSLRDRMWEISPSLVRYDTTEPTSVDVALAGLKTLAARTANAKVTGEPIKKPIENFYQTDPISRASVTMAQCTRAFVKGEDYGFTPMNAAEAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6I7</accession>
    <name>A0A2G8S6I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6I7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6I7"/>
    <dbReference type="OrthoDB" id="2420454at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050563">
        <property type="entry name" value="4-hydroxybenzoyl-CoA_TE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793">
        <property type="entry name" value="4-HYDROXYBENZOYL-COA THIOESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31793:SF27">
        <property type="entry name" value="NOVEL THIOESTERASE SUPERFAMILY DOMAIN AND SAPOSIN A-TYPE DOMAIN CONTAINING PROTEIN (0610012H03RIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="17427" checksum="BFCA10CE4D8AFB6B" modified="2018-01-31" version="1">MADQVKTLRERARGNYPFFLAYRTRWIDNDQYSHINNSVYYHLFDSIVNAYLIQHAHLSPTTSPLIGLVVSSFAHFFSPLSFPAVLDLGLRVSKLGSSSVTYEVAVFQEQSGTPSVVGGYTHVFVDRDSRKSSPISPETRSALERLRVFPLASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6M8</accession>
    <name>A0A2G8S6M8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_09473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6M8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6M8"/>
    <dbReference type="OrthoDB" id="115435at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="616"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="901"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL29421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="111924" checksum="5238474CE4CF8021" modified="2018-01-31" version="1">MVEEEEEDKPLPPGFLPEWDGTEESLLDALATGRTLRNAPKLFVSATYTYSQQLAEQEYQKKEIRPVEEIVPKQYHEYLPVFSKEASERLPDHGPYDHAIELVPDARMFHSKVYPLSPSEQVELDKFINENLAKGYIQESKSPMSSPFFFNRYPLPLVSDLMDRLKKAKYFTKLDIHWGYNNVRIKTGDEWKAAFVTNRGLFEPNIMFFGLANSPSTFSALMNIFKDLIILGKVTIYLDDILIFTNNIEEHQKCEFEQPKVEYLGVLVSESRVEMDPVKVKGITAWPVPQNASDVQKFRSFVNFYWCFIKDFSAICKPLDRLTGNAPWKWEAEEQEAFDELKRRFTESPVLSMYDPDCKTREGEDSKWHPVAFHSESMSNAECNYEIYNKEMLTIIHALQAWHHYLEGLPSVFKIQSDHKNLKYWKTAQNLTRRQAQWALYLSRFEFIILHKPGTSNGRADTLSRRPDHQTDDADDNLNRDLLQSNRFRVLAAKRGHMSVVPEKALLRHIRECGECKQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRSRVYVPKDNALRAEIVRIHHDLPPAGHPGQAKTVELEYVETCDTCCHGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDRYNALQLIADRHGKIIHLIPCTEEIDAEGTADNFIREWFRLYGLPRKIVSDHGPQFSSKLFRAVLKGLGIESAMSTAYHPQTDGQSERWNQEIEAYLRMYCSRRRDDWVKWLPIAEFAFNSHVHSATGYSPFYLMYGFEPQFHIPMLSTAVPSADERREELQRMKEYYDHYVRDAPEFKDSQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKRKVGNLAYELKLSKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESRRYGRWKKLQYLMHWMGWGPEHDSWEDAADLANAPKVVQKFHSTHPDAPSPLNKKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6Y0</accession>
    <name>A0A2G8S6Y0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichothecene O-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6Y0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6Y0"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009992">
        <property type="entry name" value="Tri3/Sat12/Sat16/Mac1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07428">
        <property type="entry name" value="Tri3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54766" checksum="9797AAE8193C0153" modified="2018-01-31" version="1">MSGPEPGWEQHPSRTGAYTRSLLASEIWTDQSARFNDGLSQFAIGVQLTTTIHERDIEARLKEAVIRLRFDCPLIAATIERGLHHADFGSWVYAPPANVEAARDWADKVVHYLRDPIDSESFLQSTVETHKIPYVLADGFEQLFRVYLTRPDSTLNTYLLSVHTSHSVLDAKPGLNALSLLLEFMSTPGSAGIDELAWGTEHKNLPPGPITVTGGPREDWGTKGTAMVDKFLSAAADQTPSHGLDCDTSVPRTPGKAHRLLVKFTTGETAKITRALKTLGFTFSELIDAAAIVAAFEHKPVPADEVDTTRVNGASLIAITDRLPPTVDRRRHLVSCMVYTPYRILYAPLAPLTGKARLLAAMRQAKEQYDAWLAEPCLPHLIAALAPQISPNKPAQPPPPGRGVFAPTMTNVGRVENYVALGWPRGAGAGDSEEVVVRVDGMHIACRMGSVWYTPTVHMWSVQGRLSVLLQGSAADVWDRDVLQDFISGIVKQISFIMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S719</accession>
    <name>A0A2G8S719_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S719"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="164" mass="18302" checksum="CD43C6368DD44A77" modified="2018-01-31" version="1">MFALVREKLKGEGVSRSGDGADGVEKQTGIRVDDHDDDEDAEEDEDEGGEETTMLSNPEDNPGEDKSPWSAILTREKVVDFGRAWKARGGVYPANINPNIRWPRPARELRCQPITMAHDRFMLEEMHRLVASACEEADGPKKDEPNADDEDEGEDDREAMMSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S866</accession>
    <name>A0A2G8S866_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S866"/>
    <dbReference type="STRING" id="1077348.A0A2G8S866"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="361" mass="40591" checksum="8E32BEF3E7942314" modified="2018-01-31" version="1">MRTERWEKYIACMGRLLGDIYTGNDAGGFNLHKPELREGIYKIISDIKNIGRIVASPMASTYIYAKDWEALALTALKYMADSPLDEVVQLCQSSKPRSKQVLPTVRLVAYSNIEDILSHINATHISQLSSLENDPKALGVNIPSPSSTTLTNDENESTKEDGDADDEDNEETEPSREDFTADHTAAASKIISVYRKYALRKASEKDPLDEMRRRIRRDFFAKSRTVEWQGSPYRFLFRRVVPCLFIATECLKDRLYGAKSAAKESLRNAHDRELESVQAALDDASRLFKEACRLHKDLAPSAAVHKARDVNGLQRLALAVECLAEQVEDAISQNRSLPWTADLDLFRLIRDSGVLARAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8A6</accession>
    <name>A0A2G8S8A6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S8A6"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1150"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1294"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1178"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1351" mass="152666" checksum="70335D67E59BD56E" modified="2018-01-31" version="1">MSLKGLAKRFHRSRSAKDNASSGDQENDDTNSSSRGTSTPTRTGTPDPPAAAVIPVNMPTPEPAESVTMPVPESTPAPPPEPEMLLNSMDGALAELTPMQARLDAGPAVKKLDKALDTLGDKVTSLNNQTNKVMTVANNISTIVSAAASSDIAQKIERGIQRFADDLPWLMKALDEVARIHPVVTVAVLAFKAVYALESTRQENDRRVMTLYVEMKDMMMVMVQLKGVENRTHVGLDGRPLKDRLEELAEKTAKDIKACANFCDTFVKKKLLVKVFKGPVWAEKLTAFVKTFSDRKADFEFALTMHTANSVSDVKRQNYEIQAKLDAVLGLFNKFVSAEERRIATEIDARGGYTKVRQDDEVLKALIVLDNSVRPQASDAPRDVLREKTARNKLSLALDELKVELREDVEDALEKNFDAFTGKFELQVDLLQVALEKYIRAENDRVIGAVTDAIKQGPHMKIKDLELRKIWQDMGWRGNVKARLFVLTLQDHYRDLFENATNAERPDTIANDEWALDYLGLNWLRPLMEAFDDDASGYVTITEVNKLMDMRPSTLTWSIPHWLAYWAVGWRVASTSYISRIKIAIGRMREALPSVLPGNRVDLDWYFLHHWHEVFAAVAGFQTWEDEALSDRFQEYIKYEEDRIRGNLEKIKYNIDTAETVTLVVGSGRLEKCFLVLLCLVLEHDLRLVRAATRIVILRQELTNVQTTIWHVFRAFDRRFVELNDLFVEQKVDRKERFKEFAFGLFFQVSPYSDIWSTSNLSGGTFAIYLPDEQGPITLDGIEAETKPSTISTAMFDTVDTETEDDRAAPDPVKPIVGEWNGFAYIESIYPRRPMLTLRFHYSTKEGEDFCGSGVEFDDDSYTLSGTCIPKEDGRMQVKWDISYPDGVAVHYNGTLVDEFTIIGTRLYGDDTESDYSFVLKKIPAPYMTLRPRPSLLAASRYRYLWHYAIAATLQDVRQRRWSWSYFAARRDARRKYIEENLRRKRYIVEPPEEVYNAGMNQARGSCTAVEARLYERVCEHLYLSLPYHWSVLCEAPPGTTVGGHYIEGARCICLTCVPDKDDFSRLVSFCDDPACLGNEHPEGFWSPTFYGADTGIVHRTTHDILKVRTVINHLLWPSLSGQAEMALGMVRTPGVLPDPPVEGAIVSTAEGQTEDSPEAPKPPNSNVVEPETPSEAHVTDDETHKENPEIPIATELEAPSSPPACCIYYICDACDKQTLIACWSCQKPFPQPEWYYGFKPTDFTCPTCCGRGVKGPDPEDPSMAGLRRHIYTHPLVRCKRLVPDTQPEPETEQKTTDARLAKLEERIEQLQDQLVKLESNQEAMQALLLSRFTEALKRLQSIDSVNGQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S972</accession>
    <name>A0A2G8S972_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07483</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S972"/>
    <dbReference type="STRING" id="1077348.A0A2G8S972"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="30"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="15295" checksum="15FF71D0C903DF9E" modified="2018-01-31" version="1">MECTVRGQRATSSPPKASHFVPASAPFLRILTGNARVDVREDKEKNLVSAMFELPGVNKESLSVGVHKSLLTVSGESRSESGSSGNVYLLRERRFGHFSRSITVPEGIKPGEIKASMENGVLTVTYPRHASEQISKKIAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9L5</accession>
    <name>A0A2G8S9L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_07150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9L5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9L5"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000013">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="331" mass="36675" checksum="681C05BBF9B6F50F" modified="2018-01-31" version="1">MEADLHAIIRSQQPLSDAHFQSFIYQTLCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGYSPGGGNSGARGAANQGFMTEYVATRWYRAPEIMLSFANYGPAIDVWSVGCILAELLAGKPIFKGRDYVDQLNQILHYLGTPSEDTLRRVGSPRAQDYIRSLPIKPRVPFATLFPRANPLAIDLLSQLLHFDPAKRITCEQALNHPYLAVWHDPADEPVCASSFDFGFEEEDSIEGMKRLIVEEVHAFRAEVRAQARAAGQIRRQESLPMPTRDEILNSPATDQGPANGATSHYTGGKSEARPGSPILDDPSAELERELAHIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAC6</accession>
    <name>A0A2G8SAC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAC6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAC6"/>
    <dbReference type="OrthoDB" id="2801180at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="70891" checksum="0CAEED7E31CA4DEA" modified="2018-01-31" version="1">MASALCSAQHLPIELVRRISDHLVGIKKWETDAPLPKWMNAEYARPSRDREMDFIGLRTLPSLATTSHFFLEPALDALWYTLPNYGILVYLLPRDAWTVDSVADEPPDIPEEERINPPVRCVSMTRRLTEEEFKRIQYYTPRVKRIQERCPLFPRRLRAYFMRYDHSILGALAHWCSPESPLFPNLRVLDASPASEDLCPAYYRRFHFLFGPQLQRICTDYTTFTDPRWKIVPTHEYQHMLMQLLESAPHLLHLILYADAPPYTPTIVSAVSTAIRTFKNLVTARTGSLPIAEEALRHLAQLPHLEVVDVRLPDTMAEGDVAQCFHPTRYDDFFPSLREVWLAHRSDLAPISRVVRSVQSSQLEVIRAHLLDRKAPIPFNGVLSFLSVVLDRSNSANIKGLSVEASIKHTDPEARSTFTEDHLGPLFALRGLTHLSLRLRCSFELDDAILARVARAWPHIEVLELGPGVQWDTQVTLAALVPFAQHCPHLHTLGIPLNAELAGLPAEVREAHREGEGSVQRALKRLKVGHARMSDGLEREVAEFLVGLFPRLSDVENDTIPAAVTAVAVVLGATEEEVREEGRLSDRWLHVNNWFIPHMREWEKTLDEADALGMKREGPRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAQ6</accession>
    <name>A0A2G8SAQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_07014</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAQ6"/>
    <dbReference type="OrthoDB" id="1742084at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="11">
        <location>
            <begin position="424"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="623"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="778"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL30846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="90818" checksum="0DAE6A0BB8CE32C4" modified="2018-01-31" version="1">MPLTAAQKTAIDEVVRAITSASSRRAKRRLADMFLELVDKEYWPEYYQVIPQPRCINGIKANLAQNKYKNPLEVFDDLNLVFLNALHYNEDASQIAKDATTLKGILHSEWSQRSVLPAPPPIPAPATHKGNAPKDPKERAAAPPPPAKSQTIAASSSKSQSRSSTKPASPPHVDQSPVPSPTHVSQSQSNDVKKEPTPAKAKAPTPEVDLPQDMDVDIGGTPEPEPVMQDLARDNESQDIIRQLEKGLPRWQGFADVGWVEDIAPDRMVDIVTTLSKYRDESGDRPAASLEGVPEETSIPDLSFNFPLSLRLVETRARMNYYETSQSFDKDMSQLFLKARRWYELGTDAYGNVLTLQRFYQALTSPKPPASPHSSPTKFASLPAGPGTATPLHSSEGDPATRVTTFRVSEKDKKIVDEVNYKGWTIRLADWLHLSNPDDPSRPIVAHVFRCFVSEEAGEGSLAFQYAGTIGLNRRVGSALPNRRRNAELLGALQTFHPSDRQFWEQEVFKTGHFADHPLEDIVEKIAVQFTARHVRGRPRPPCWHPGWPLYVCDSRYNDRERVFVKIKNWNSCIPEEVRKNEEFMPIYPFERPVFPRQHASPFLGTAKITAPGGLVDENANQAEKDKAEVEKPDSSSAAAGGGGPGTRNRTRPKRTVVQKAEADKAAAAAASRGVSAVPMQPSTSQSSSYQQQAQQPQYAQAYPPPREDRSIVAAAGGLSALGSSAAMEELPAETARHFDRDPETNEVLWFAGPPVDIVHTPPPRHSLKYLAHLARKRNGQHREHAMDVDGASPPKRRKMPLTATETLAALLKEHGLDQGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBA2</accession>
    <name>A0A2G8SBA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBA2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBA2"/>
    <dbReference type="OrthoDB" id="2642524at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="482" mass="54045" checksum="83D020FC86185D2A" modified="2018-01-31" version="1">MAFTAPLHLTVIQMDGPLLLRCEKTGRLTLSISVVDNDHDPGLPHEVALGRDGQNPNLKSVIPVHEVTATTKLIIDVFHHLKAKKKHMKRNFVGSASLSLHEFLNNHPLPRLGSVDYDVQLACYPPQCKSLTLEDMQQYGATLTMRFKVYRSSKPRPYQLDSPPLSPVSVSEHYETEPPLLSRAPSSSRGAQSETLYTNTPNESGEEREREQRPWGKQESDNCPDGTAGLRCRHCRELHGLPVDSDSRAESPEDGHFPTIYDDELRRNADEDDKGEVSFEERFLCWISPYKEITEAAEGRDWRKAEKVLARLQPVWHVVSLALPVLAMVNAGVVTVAPGALFAQEGFPRRALMVSTVAIFSGLMFNAMFLHCYGSCRCGAEFLFLAKDLWADTYVSFSLTCRLPILCLAILMVSFMASFLAVAWTAWPTAMLVVSFVVGLLLTLELVIFGTSRLVSFAIWFKGDAWRTLVRFSLYRPWCPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBD2</accession>
    <name>A0A2G8SBD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBD2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBD2"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="58"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="169" mass="18955" checksum="7DD1B74B698EADBA" modified="2018-01-31" version="1">MWFLISGGQAHWEIRLSSSRGVVYYYNHDTKESVWDPPADLTPEQIKALPGAQYLNRPPQVRASHLLVKHKGSRRPSSWKEPNITRTKDEAIKILTGYRDEIGFSAQKFAELASLHSDCSSHSNGGDLGFFKPGQMQKPFEDATYALEVNEISDIISTDSGVHIILRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBD9</accession>
    <name>A0A2G8SBD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_05749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBD9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBD9"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="240" mass="24992" checksum="38C516EBC753355C" modified="2018-01-31" version="1">MSSSRAGTAWFVTGTSRGIGLEITKQLLQYPNNIVLAACRSPSKADALQDLTASAGGRLHILRLDVDDAQSIEDAASEATQIVGEKGIDYLINNAGINPGGFDTAFGCKVDDLTAVFQTNVIGPALLAQAFLPLVEKSGKKTIVNVSSTLGSVGTDLGQTFASYSVAKAGLNMLTSKQAKERPDVTAIAMCPGHLQTDLGGPNATTPVSVGVSGVLKVVSGLTREDSGSFFNYQGNRVQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBG8</accession>
    <name>A0A2G8SBG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBG8"/>
    <dbReference type="OrthoDB" id="2791154at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="204"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="430"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="816" mass="90210" checksum="CF620B3409338F06" modified="2018-01-31" version="1">MTLSSGPPSRGPKSILECNPAGEASSSPRVLRARTLSDVSGTSKHDRRRLDLDREMVWREQPLDAWFQNYLPGADPTGVTFAPFEVELANQEQGMYAGLRDGLNSCLRAVGWDGYEALTTDRLPDSSASGSSGDALRPDMGIYPIARARTGPSDDSLDARVAWAWLELLIEVKWDPKAAPFSSRYTPRSAFLPTGRERCLSRGQLAEYAVEQLNRQHRQFLFMVHVMRDCARILRFDRSGAVVSEEFDYVAHPEVIGTLLFRLSRMSRAEQGHDPTATLASEREASMFKELHARFHADSATARGLRNAVVEGWPIVKITMDVPFSSDGAPVRRGTPPTRREFLVGKPASLSLSLVGPGAKGFVAYDLTTNAVVFMKDSWRLDSRDVQSEYETYLQLREKTTGELYVPTLLGGGDVSFDGSLQRTASRDDAPSLVHCRLVFKEICRPLEDFTNSFELVKAVTWALVAHSKAWKQCGILHRDISVKSIVIYDSDDLGTPTSIGTLQNRGTPGPVETLADWDVGWWPREGIGRDVARIDRSDSWPFMSARLQEHRYPGRQHDLADDLESFMHVLNYCALKHLPGAASTEAESAYLTQCLYDAVVPTDSPHPKGSPLKLEKVKNGMPFVNSLPAQHPLAGLLAELSQLCKQHYERVVLPESPPRSPSPEETFAEGSCDGSQGALPDYDGDLLDSPDSDELDGWPTQTCAPPSPHVNIALSPLRSHDRMVGACMKAIRKVWPAVDRRDRPIPTRTRPRPLVRTGSRVGAKRTWSESDCSELDGAGENMKPKRVRRGSESSVVLSLSGTQNAGGIPRRRSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBV0</accession>
    <name>A0A2G8SBV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05943</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBV0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBV0"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="444"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="257"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="510" mass="55138" checksum="2FD5F9C03B11A7A2" modified="2018-01-31" version="1">MDAAILLQLSHSSSPHHQPLHYTYFGDRVADRNTLAAHSSFVRSSAPRQMPQYTSQFLPSSFRSTYSMPSSSSGSGSFVAGGSRVGSPYELSDAELHTPAPQTYHAEQYPSASSSWSQQVDQSQPPQYTADPYTTASYELTDSNVMHSPVKNEDAAHIEPYAGLYLPPYTDHIHGSSPLNNDQHPPLAAAFNVATGHFQTADSTPPQMSYGYPSHEHQHQQSGGPDVANLSPYMLGNDAPLPYADYAEGDMPRFVHPAQVSPPSPFAQLQDVGAPPGQSCDPRFTMNPVHGLGSSGASPSDFTDFELDSGSTSGGDSPSASLALSAPIAVPPQGARKRQRSVSFTSSSEDEYHASSGESEQGDGDDDDDEYVQSPRTRRRGRQQQGAECPQGHSPSTSPGSSLGGGRRLAPPVPVPNLTKKSRGRRVPTVQQVSEGGMQKQRMYMCKVPGCGKCFARGEHLKRHVRSIHTNEKPHKCPYPGCGKDFSRHDNLGQHMRVHKGFQMPKGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCC1</accession>
    <name>A0A2G8SCC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCC1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCC1"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="365"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="655" mass="73130" checksum="7E222D18D1EB1414" modified="2018-01-31" version="1">MAHSLDDDEHDAHPISGHRMIPSGFSFNDDAFSDTEDIDVPEFSPARLREELAKNMNGGSNGNGVAVDNWSGGFDMDDIVAKIGYSVDPDASVSTFDIDGGHESPPSTPLSPVQVAGSPSPPQRMMSQSSSHQDSLYDIPLSTELSRVSLDDDPPSPPAPHYEEPKEDATQYPAVQIDLSGPEALAREVHLDTSSSDGADSIEGDHPLPRQHAASMDEVRKALPSPLEIPAPAGAASTSALPLTSSASVPTPTSAGLTEPPTPTSRHRPSRSAGPSMLDKVISKTRPTHLPPKPRTEDRKHQQVWEEMMKRSRAAEEKRRNALQERRYARERRIEESIGVWEREIVPDWTVVQRNAQLRRLWWHGIPTKLRASMWQNAIGNPLALNKDSFKTYLSRAKRALASGSFPTTVLGLLEGDIQTTLPSINLFTPGRGPLYQDLKDMLCAWVVSRSDEGLGYVVGVSKIAAMILINMSPLQGFIVMRNLLERHCLRSFYGGIGSKDDVEAYYRIFDTLLADGMPKIYFNFKQHQVSPASYLPDWLVPLFLDHLPFEACARVWDVIVLEGDAFLYRAALAILGVLEPRLFFPEKKELLELLRGENKAALEVARRDGRTIDNGKYEIYNVDEESLWERIESMDEWWRESTWKRLIERELPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCD6</accession>
    <name>A0A2G8SCD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCD6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="11286" checksum="9A303F611D81F07E" modified="2018-01-31" version="1">MSSERVASSSDTEIVDYTWGDAPYMLPDDRGRCGRAITGRVSYGDSSASDYAQAGLEFGRGLAGESVAVGNARDENIMLLLMRVRWPPGSGVNGRLSGDTVAFCQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCJ2</accession>
    <name>A0A2G8SCJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCJ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCJ2"/>
    <dbReference type="OrthoDB" id="3238632at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013950188" description="Transporter" evidence="2">
        <location>
            <begin position="17"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="56618" checksum="5BFFDE883048C85F" modified="2018-01-31" version="1">MNSVLTALTLAGAAAAQIVAGSVSMVPASQVYATSASGNNQAAASSASATSASGSSSAPASQYTQPPATDGGYSDMPYSSFMSGGYKSMNCGYGYTKGSDGSCQAMSWWQTQGCYETIIINHGGSGYGYGSGYGNNCDGSTQTVTKTETMTDTMTVTMTDVKTVPTTVTMTDTKTVFQTKVETDTESITKTQTMIETSTKLVPTTRVWVSTEIIDNTKTIDHTLTATETSTQVNVYTKTMTDTETATQTQTKTQTETDLMTVTKTQVSTQTVPTTYISTWVSTKVIDNTKTIEETQTATVTDKMTIVSTDIQTQIQTKTDTVTDKMTVTMTDFSTIIKPTTYLSTSVSTQVIDKTKTVENTIVQTMTEDRTLTQTNTYLSTITTTQTKTDTATMTATETATATETVTDSMLVSCLQGCKTSYYITPGNSASYTYTSTSTAAATSTTSSSDCGSNSKDGTCNPKSSSSSDCGSKDGSCNPQSSSSSSSSSSYGNDCSSDGSCNPKSTASSSSSYSSSSASSTSSSSSSSKDKSSSSSSSGSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCQ7</accession>
    <name>A0A2G8SCQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06233</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCQ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCQ7"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="6">
        <location>
            <begin position="150"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="415" mass="47435" checksum="008EC43FF14F6A01" modified="2018-01-31" version="1">MLRRFWRRLGAEQKRSCDTSRVSRSIYEDVALALTKISMTSQLWHPAAHGVLRLILELNGEEVLRADPHVGLLHRGTEKLIEYKTYTQALPYFDRLDYVSMMTNELCYSLAVEKLLNIEVPERAKWVRTLFGEITRILNHLMAVLTHTMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVAFDLPHGMLEDIYKWATQFSSRVDEIEEVVTGNRIWKERTIGIGVVTAKQALDYSFSGVMLRGSGIPWDIRKIAPYDKYDEVEFDVPVGKNGDCYDRYLCRVQEFRESLRIIDQCLNKMPTGAIKVDDYKLTPPPRASMKESMESLIHHFKLFSEGYSVPPGETYSAIEAPKGEMGVYLVSDGSNRPYRCKIRAPGFAHLAGADFMMRHVVAIVGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDY3</accession>
    <name>A0A2G8SDY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDY3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDY3"/>
    <dbReference type="OrthoDB" id="1917726at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="112" mass="12409" checksum="44B1874F8A07D491" modified="2018-01-31" version="1">MRIWGPSVREQGLGTEHYLTAISFNGLWELYMAMGQLDKAEYLNRALAIRVEKGFPEKLAVTRDSLGRLFEMKGDLQAAADICRQGGPDNVACSNHSGVSRFLPVAFLGIHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFR4</accession>
    <name>A0A2G8SFR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_05240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFR4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFR4"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL32537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="23709" checksum="B9CD4382480C2B34" modified="2018-01-31" version="1">MVAIVQKPAPAFKATAVVDGLFQDISLSDYLGQWVVLFFYPLDFTFVCPTEILAFNDALPQFQQINTTVLGVSTDSHFSHLAWASQPRKQGGLGPDLKLPLIADKSMSIARDYNVLIEDEGVALRGLFIIDPKGTLRQITVNDLPVGRSVDETIRLVKAFQFTDEHGEVCPANWNEGDKTMKADPKGSLEYFESVDGQQAAAANGNVSRKRPRHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG08</accession>
    <name>A0A2G8SG08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG08"/>
    <dbReference type="STRING" id="1077348.A0A2G8SG08"/>
    <dbReference type="OrthoDB" id="2744237at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="429" mass="46684" checksum="4C4BD4EFAA370A50" modified="2018-01-31" version="1">MPSPDQTERITRTEQIRIFLRLAIASPHVHRAIGLFLSAMRFIRRVFVPVFTGVVGLAGCAIRIVLGVLAFFKLPIIALLAGLVMVSVVSFGIASLWRSAQATLMSFDFCELPMVCAHRHFTSFNICDLPFVPVVVPSCGALPPASVSRADFPGLLAIQHRAFDDLVAGSATNSELIVNVKRAEVAIRDLVVLVKASNLTTKEPLAATLSLFSVDAHRTGRGLQLLMSKTYGTIDRLIAYNTYALRVIEAAHKTFPQDDLHIEATTIRTFQASMASFSAAVSAILVEATTVSASLDVLEERLSTIHALSIQEALDTALAKDELLWQLWTVLGGNRRQLRDLADRASILQSVQQYRALASAYIAATVQALTVVDADLTQLREQLSIQAIGCDSIPVEVQVRSLERSLRRLQESSGSDTGPTRTSHGNLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGC6</accession>
    <name>A0A2G8SGC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGC6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGC6"/>
    <dbReference type="OrthoDB" id="2753930at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="306" mass="34629" checksum="F86930531A22F96C" modified="2018-01-31" version="1">MLILFVEEYERIYYGRRVDRLHFIRQSIHALTHTTKECEHVGPGAYHTQWTMENAIGNFGKEIKLHSDPYANLSERGVRRAQVNALKAMLPDIDPDVRPLPRGAHDVGSGYILLRAMENTANPVRAREGGVLRKYLEDSGEELPADWIPRVARWARLRLPNGQIARSYWKESLKPISRIRIARNVKIVQQHIVQYAEVQYYMRLRIGEEIRALALVSYYSAPDQTLLDLSHGTIWSCTAGGDTDLGIVDVRKIESVVAMIPHPRPIVPRPGDLDLSGRYCVVEKPGLEVAYLGGIEEDVEEGDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGY5</accession>
    <name>A0A2G8SGY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04945</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGY5"/>
    <dbReference type="OrthoDB" id="1938621at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="98" mass="10983" checksum="A33206AFE02C54AC" modified="2018-01-31" version="1">MRENNIAAGLRVSAESGGYHGYQYELKLAKKGERDDYHFAHPQIHPSNVYVDAVSMTLLKGSIIDFATELIGSSFRVVENPQRFVLKVYVQAKGGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH67</accession>
    <name>A0A2G8SH67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH67"/>
    <dbReference type="OrthoDB" id="2748248at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="586" mass="65454" checksum="447DE9AB286E8033" modified="2018-01-31" version="1">MPYPSSTILPLPRLASLLSTRDAAALEKLSDVPIDKLPTEILQKIFADIPSEYRGSLHAVSLMLSLQSVCRRWRSVLLATPEYWVQGIQDVTDLYVARVFLNADEEDGVVGKRANPRLLDLFLTRSAPCPFQLEDYMSIPRCPGWKAFVSHFDRVNVFKVSAVDAVDLRNNILPAVATKMRRLERFELSLPRFEVSTEGIDQWEAHNLPHLQIVNIPSTLFCRAMAVPSLHTVTLSGERDIESLPDLLAALERCPALSTLSLHLSSNRHSVTTRPTPERTVELLNLRKLVVAGSTSGIYALLSSLSFPSATHLELFVTDAERSQSVLPSVLPRHHSGLYTSPTLDRVGLHTHFQHYDDTEPEWVSMRGFVQDEERLRVSPVLRLDSGADGFLQVAGALRACTLTALALNLFRVTDDMDRAFWARFFAALPGLRRLELLSAQHRDSCRAMKRDAAEQFLAASRANLKPVRERARRGVSLAWRLCPDKDDASQLEREIGDVEEVVSGHAHHGVRLERLELYACAFGIHDLCSNVVDVMQIQTDAAASQLVARDCVSRLESVVEVVVVAGPWTVIRGRLGRRARYASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHB5</accession>
    <name>A0A2G8SHB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHB5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="109" mass="12665" checksum="AC76DFE2211D3825" modified="2018-01-31" version="1">MAERKFAEGKARADELERNRQRIRNTLQHICEDLGTQSQLLKTVFSDVMSQLGKQSNEYYLEACRHVHAEGSAVNQLALPNARHRFLSTSRAWKEREATLTDEYAKRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHM3</accession>
    <name>A0A2G8SHM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHM3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHM3"/>
    <dbReference type="OrthoDB" id="2749068at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="253" mass="28685" checksum="94FD4ACBBA6AF334" modified="2018-01-31" version="1">MSTTTKMPYVRLGNSGLKVSKIILGCMSYGDPRWQEWVLPEEEAIKHIKYAYDHGITTFDTAKGSASFRLHAFIYSHGQSEIILGNAIKKLNLPRDELVILTKVYFPIAKEGARLDGNPEDSGIINQHGLNRKHIFDSVKASLKRLQLDYIDVLQCHRFDYTTPIEETMPPRWSLRGAASRGAKRRFYSILAESSRIAGAALEEDRTPEAASPHSLRLLSPVFAPHQRALQSITQNPHQNRREDLGWSDLTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHM5</accession>
    <name>A0A2G8SHM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHM5"/>
    <dbReference type="OrthoDB" id="2751071at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="61"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="598" mass="65094" checksum="800E5F50DA3278FB" modified="2018-01-31" version="1">MARVEETLVELPFPDLASSLPIADRTSLVGLSPNDIRAWTSARADEYLRSARALFSIYNAVAPIHSLPAEILSRIFEKCWTGRKSLRVGHVCRRWHSVLLDSKRFWAHAVNAGHFTPDDHSTGYLGTVLQRSAPRTIEPSFFHFSAGVPECLALHAERVVSLEVACITHLVLSPLWSCLNSGTMPCLATLTITLDNDSYRSIVNAPIEDLSLSPAALPRLTRISAPVALFPTLGLPSLRHVTLDNPIKHEFLGGRLESERFCKAFTVCAPGLHTLTLIGAAPYTTATPLSLPALCHLHVQDTARCCSLLLLHLALSPTTCIHCTNVDGLGLRTTVPIASDAVRSTVGATDRVVITSTTETTSLHCYGGDEERLRVDIPFSLTLATVPEGAQAAPVLRPDSLIEFFRDRARVTGLTVVGENRADMEMVEWRAFPHLVAATLRGQKAGYAVENLARWQLGDGEGTPAHWQAGGSPATTVVCPGLKTLAVDFQFVLGAQRTDGLGSALALRGGDVAGVEADLRKRCADLERALSFRSETGTRLERLEFGCTEQGWSEGVEERKGTLDPLNSDWTSWRAIVEPLEKLVDGPVVFTGYRYLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIL2</accession>
    <name>A0A2G8SIL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIL2"/>
    <dbReference type="OrthoDB" id="2751365at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="460" mass="50933" checksum="E87C1844C2D99E56" modified="2018-01-31" version="1">MKLLSEDISESSQEFFRFGELGSFVRSVVPSPNLGCVCEVDHIKPSVWFYLSRISGRKSLFPHLQELHWFIEEPSDTELLLVASSSLRRLFVCYGGCGTISREWSLSQSMLFRKTFNTVPHLTHLTIYDTGTGGAMFSACLSNSNIDMLRNLRRVSLDEEESVNLDVLRSLSFLESLEELTIGIDSIDDVDFVGFPALTKLSVTGAMSGTSPQVFNAFSSPHLRELTVCDRSRWTDTDNLLATSTTLTQRFPSIADLSLFLCAPLRAGASGASLEAALAPLFPLPIAKFSLKIQNSFVWPLADDFFTTLAQSWHHLRELSIVVPHHRSDPVLSDIISTQTLLALTRGCPQLHALRLPEMAVPQLGESGTFPVLQHPLRSLALDSLVEVLPADGQRLTDEEKCTEFALVLDKLFPELDTRNAPPGERPPPDLWKRILSGVRLCQLGRSNRVVQAEGAASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIP6</accession>
    <name>A0A2G8SIP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIP6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIP6"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="251"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="675" mass="76000" checksum="ABA3606D8CD5F669" modified="2018-01-31" version="1">MWLLSTDRAELHYFSAPESVPDGYAILSHVWDKEEMSFQDIQALRKQCASRGLKRAARFFKFGLGSTATPRDLASDKIRQSCIVAERHGYKWIWNDTCCINKESSSELSEAINSMYRYYSLAEVCYAYLGDVSQDVGGLYSQVWHGSGFMESRWHTRGWTLQELIAPTFLVFLSKEWQVLGTKANLANTLQQITKIPATVLRKEIDLGSVSVAQRMSWAAERQTTRLEDEAYCLMGIFSINMPTLYGEGRRAFYRLQEEIMKQSIDISLFAWGSCAKLPAFCSSGMARRGSSSGHDHQNPELYLFASSPSSFKDSTTVVFWPPRSSRPSPIHAADPPSSRTYHSFYLDGLPTFSITSYGVHARVPILEFRGLTIAIICCHVSARNKTPMALLLTRCPGASDPTRPLYHTGGPLGERMALMDMTIASRNAVPEWRDIYITHRPPPEAAASLDPRILINSSNYTPYRISRRSLDAFLAQGWELHSVTSPPQVPWTGSPPATFTFRRTGARYFISIYLGRCMHHATDGAEAVADDDSDDSEGEREQVGLFDGYAGYGTVAAHGQLLPEHPSWLAEPNYWKEESHPWRGRSWARADLHVGELPSGTRQPEPDCDEDHISEWPDWTKTFEMSTGWINHYITLSFAECPINPKSTLVMDIDYWEAAKLGLEVAGRRTGMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIT4</accession>
    <name>A0A2G8SIT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIT4"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="444" mass="48185" checksum="95BAADD7FC2C7F07" modified="2018-01-31" version="1">MAVDILVLGATGFTGRLIVRYLAQHPHRNTFTFALGVRSKAKGEELKKVVGIADDGSVPVLLVDVMKYDMVEAAVRETKIVLNAAGPYWLWGTNVVRACTLLGKRYVDLSGETHFQRKMVELFDHTATKTGAVIVTACGFDSVPSDIAVFLANRTLKNALGSQTQLGLSQSFFHIKGGFSGGTMASLVTEVEEVPADVVEECEKDYALSPVKGHPSPPQQTAVRIPFSQPPMYGAAWIMASSNSAIVQRTFGLNALLAEHSSTVLASARAEAQKTGDQIRPLTYGPEFRYEEYMTFSRSRFAASTFSVLLGLWFALMYTVRPVWWIFKRFLPKSGEGPSEELMKSGYMNVINYTEAAGVPGTWAKTTIRGKGDPGYKLTSGIIAECALALALDDASLPPHAHIGGVLTPATALGSVLISRLEAVGLVQFESQIVRGNEESRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIY4</accession>
    <name>A0A2G8SIY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIY4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIY4"/>
    <dbReference type="OrthoDB" id="2930792at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="314" mass="35223" checksum="AEAF88F13DAE8CE4" modified="2018-01-31" version="1">MAWGYAVIRINPTATVLEDFGYPDILEAARAMRPKPHLVFLESELALSFPHDPWYPYAISPITPCPPPMAKGHNPEMCVPVFPNTHHRNGREAVRTDREFPYNNCYHWSMAEELKVRVRAKPENFDDGIAVHLPARELMKLWDMTSSDRIITERACKMDGPVGEDARLGAAPPTPLVSTADLGVGEEILSRAADEVDATALLEEGIRQGRDIHQHPSQESIKSEPSTGEGMEHDEDVSESHSLSKSSDGREVSIHSAASEFRAIVATGIFGLTNEERKFWPMVDLWLELADYLKQEDIPDPHELYREYEAALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK00</accession>
    <name>A0A2G8SK00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK00"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK00"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF215">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56641" checksum="E31CF4566914B2A4" modified="2018-01-31" version="1">MTTPLTHIVGYPYQAWGHARPLTNLFARFVKLRPVTVTLIATNGFYDRVKNELARSFDAGEEELAACIRVIAIGDIEFFFSPEGDEQFKTAWQSIIAEEELVCTKTGTRYAPLPKPKAIIIDFFAIEPFHAIKALSGNTVKVFSWHPGLTYALFHLFGPEHVGGRGNLLPLIEEKVRQTGRSFGEVSREIHFTPTGTLVRVPGMPPMYDHELHPQVLAIPEDMYTLFPRVYQTFEATDGLFMFTPTSYEPEAVAAAKGWFAEKGRPAYAVGPLLPSASKTTAAVNERKQSAESSQIQEFLDATLKISGEKSLLYISFGSIFWPVGKPESIWAALDVIMELKIPFILSHASPFAAKIPDEIQEKVKAYGKGFLSPWTPQQLILDHPATGWFIAHGGHNGVTEALSAGVPQILWPFGGDQPQNAVHIADQLQIGYELLEVRTADGLKPIYRTGYTPKGTIEAIKAEVREVLQKAFGEDGAKKRAKLEVLRKSVNGEWEEGGTSRKEAAAFLDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK82</accession>
    <name>A0A2G8SK82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK82"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK82"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="790" mass="87048" checksum="233E692229A510E2" modified="2018-01-31" version="1">MERVQFQQEQMLNELKDLVQKGLFSQKEAKQIMQKRTTFETALVRRIPKKSDFLRYATYEMTLEALRRKRAERLKIAKGSPSVSDYALVRRQFQIFERALKKFKGDVGLWIQYIQVAKKEGARALVGRITARALQLHPNVPALYVLAASHELEHLSPTAARALLQRGLRMNSDSVEMWREYVRMELGFVESLRRRWNVLGIDVKGKGKDAGAGTGDKDNGKEVGDLWSGIGDEDEREVDGMDMDAEDDLTEDEVARRQIMEGAIVKSVISNAVKAIPRIDLFTSLHELISAYPSPPTLRESLLDHLHVHLHETLPSHPVAIKLTATRHLVPDSEGETLVEALKSANEQLLNAVRRADKTDVPGIAKVYAEFVEEWCRREVDSSLKAYLITSFYLLIQQLSTPVPPDLLAAHIRLLVSHHGGLELALLPPKANTPEKILRVARKYSVNAPLCAAVWLARLAAEKQFAGQEYVDRAWTEARTHVEGDGTPEVWLWGLAPLNRHGSSANAESEVDVNAEVELVEHLLHESQLIRHPATADALHEALLIRYAAATHHALSLLYRSPSSRHGSTPSSLSAAQSIAAGTTSLGLATSVREIAPAQRKWRRQDSNADGPSAKTKTGHHSVIPGDEPDSGLPSTRPPFLDARLARVRRIGTAYYVPSARVWSEVFEQESSAGSSRASVGGGAISGGVGPGLYSGVDVDEDARVLGSIYEFWRQQDGAGATIAWATWLLRNGKGKDATGVIARGRSVLGEADGERVESKWKKILDGDGCVGEDGEVVPTLDSLSDMYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKI1</accession>
    <name>A0A2G8SKI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKI1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKI1"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="15648" checksum="BD626F7367F9FD63" modified="2018-01-31" version="1">MISSTDSSPSLRPDRVRLVVLMAPKPGLSFAEFDRYWLDVHAKVFSSIAIVKRNLLKYEQFHLDPRYDESIAAQSLARSKSRFRGIAIFEATSLDKIFEIFQDEEYLRVVVPDEHNFFDHENAQILAGPFATIIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL40</accession>
    <name>A0A2G8SL40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL40"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="88" mass="9771" checksum="C985B4CC871C1079" modified="2018-01-31" version="1">MEGDGVDLVSLGKKYGYLPDAAENLDFDIPSCGDILAYDWRKDAEGQWDVEMGGGTALKWAGDYGQFSYQVAGRLDDRLSWGWDTARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL66</accession>
    <name>A0A2G8SL66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL66"/>
    <dbReference type="OrthoDB" id="2131701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23422">
        <property type="entry name" value="beta-trefoil_Ricin_MPL_CNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="204" mass="22708" checksum="1305AB6E34C62E78" modified="2018-01-31" version="1">MQLENGKTYKVTNAKGGTVLDLSGGQDQSPITGYNFNGGDNQKWVAEQQDQRWRFRNPATGLFMGYSGDPNNNTPVKAMQNPTMWDMKPDQKKPDAMRAYVAGTDFCLDLSGQGNSSPGTPVTLWKKWDGENQTWRFEQDILSDNLKAKSPVSAKAINEDHVFPKGESPYFGRWAHTVANVNLGANAQLNLQKVITYQHTPSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLX1</accession>
    <name>A0A2G8SLX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLX1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="271" mass="31013" checksum="BC9D95CDAB76FB0D" modified="2018-01-31" version="1">MSDDELPDHLKVPEALKTHPELIKRNLVLDHPLNIGSVYATSGHTPPQFAVKILDPASEEEAIVDRLQRDTSSRNHLIPCEIIRADRTLLVMPYVFRVDRPIRRERDPVKRLLVLLKVFHQIAEGVDHLHGLHIAHIDLCYGNVMAALEDSERAHPRTKAGRVYIIDFDRSRQLELGPGRQPAIELPSTQYKPPLHMKSFDPYSWDVYCMGNLFERLTTEAFRPSPPPWFLVKLCRWMIGDERGCSGVFGKHVALIRGLFVTLRSPTLARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMB5</accession>
    <name>A0A2G8SMB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02701</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMB5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMB5"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="185" mass="20331" checksum="61186E7462A02AC2" modified="2018-01-31" version="1">MATPQFTLPNPDVNQPYIEVSALEAGLLQLIHTRFIAGSQPGESTMCPSLAFLLRHSTSKDLLVFDLGIRRDLESHPPAVQKVIENRIITTPQSVEESLRKGGLNPEDVTTVIVSHLHYDHIGEASSFPNATFIMGVDAEDLLRNGYPSNPVAEVLSTAIPLSRSRVLGIHVAHRPLSTRARLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMR5</accession>
    <name>A0A2G8SMR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMR5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMR5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="483" mass="53636" checksum="B1077937C31D9A21" modified="2018-01-31" version="1">METILIALEAFSLLIASLAIYRLWLAPLARLPGPSMCAISRLPLMYHEFNGNRRSFIHDLHMKYGPIVRVAPDEVSFATREAVKEIYTSGGSGYNKPPFYFLFEHFDTGNMFSTLEKVEHADIKKQFAERYSKLHVTKPGVAFAIQENVDAFVEKATERLGASVDIYDLLHCFALDGITGHLFYPSGLHSQTSPSDHKIMEELCYQDGLRRAYFAHYFPALWRVYSKLTGAAKGPGGSLVHAYVLNTTRTSPADPYTVLDKLRAVDARDASRPALLSASECMDHLVAGIDTTGDGLCFLMHHLSLPHPSSQRVQAKLHAELQEHGGAPLDDLPYLEAVVKEGLRMFGPVPMSLPRLVPAGGRVVDGVNLPGGTIVSCQAYTLHRLDEGVWADPEEFLPERWLASEGAAERDRLFFAFAAGGRGCIGKHLAMLEMKLLLRDVYSSYCTRIAPEMTASMEQDDQTVSTRPKDQKCLIIFEKLDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMS6</accession>
    <name>A0A2G8SMS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMS6"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="266" mass="28497" checksum="C81E8D90BB89A410" modified="2018-01-31" version="1">MLPPLTTTEQSGDHEDHGYDHPEEVDSPDTLQTLPASGSSVRGEDTPGISTLQDILLSMGTVDLMFVNGRLVININLGVANNKNASNRAATLIKCMEVIPDELVLRYNKLRSSDSEGMEECPVCHDALVSVPKAPGDEDTVDASPHPIVAFPFNIDPDRKLRQYLFGSWQPPQVESMCDWLAAKEQAKEAEFAECDLAMSECPAPSPATPPSLGSEVDTNTSLDRDASPLVGDSETNGTSPSGSAPRTSESYLTVRVADDDIGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMV4</accession>
    <name>A0A2G8SMV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMV4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMV4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013614233" description="Transporter" evidence="1">
        <location>
            <begin position="18"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="21810" checksum="B578FA7BF3F9268D" modified="2018-01-31" version="1">MGALLSAVLGLVGGLLSTVVQLLSCLLCGPATCCCPLAAVKVTGGTEPTSPSSGGCPDCCSGCWSATCQNCCQACGSCSNCCEDCAKCTSCCPGCGICSACCSACGNCMGCCPGCGTDGGCPCCKSTSNLKAFGNPTTPTSSCPDCCSLCGADNCQNCCSACGSCKDCCTDCAICKLCCAPCAKCADCCSSCGICKDCCPGCDTCGCCPCCGSKVMAAARAKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN10</accession>
    <name>A0A2G8SN10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN10"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN10"/>
    <dbReference type="OrthoDB" id="5598396at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32695" checksum="397DDE1F813858E9" modified="2018-01-31" version="1">MYLSFCQRQALPFEPTPDTLSLFVINECLRGLEPRSINSYLSGICKELEPFYPRVRAIRSSPLVRQTLAGVMRLYSKPVKRKRALATDDLDVVHTALAHSTDHDDRLFLAQLLTGFYGLLRLGELVWPDNHKLRTYRKVTRRTSVELAPNEYSFTLHSHKSDRAFDGDRLLIDSDLSGAQPHTAFTTYLASRDSRFPFHSELWLRANGTIPTRAWFIRRLRVFFPSDVSGHSMRSGGATALAIAGVPTTQIQAIGRWSSDAWQAYIRKHPVVVHALMVANQLAFAGAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SND0</accession>
    <name>A0A2G8SND0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SND0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="263" mass="27624" checksum="250DFB14857A6E1E" modified="2018-01-31" version="1">MSHETLVSQFSLSDSPKLLTSWFASKPPSGYEALPYEEDSESESDEHSEDDEASEEGSDVELWVLQSPSDIEACPATHLSPASRELITESTPKRGSGSPHTRMCGVLKMSLILLTAGLPFTLLFSALSWLVGGIVLSSIFKAPPYDTASSGAAFKASMAGAPLVALAVGALTFLDFLVRRLPSASADQSQYDPQGDAMAVAVMSAAASVLAMPLGFLMAPRLGTETFGAWHALGWSATGLGVPVGGVLLCCLPQLLWCDAVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNK0</accession>
    <name>A0A2G8SNK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNK0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNK0"/>
    <dbReference type="OrthoDB" id="3253535at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="47426" checksum="57CEBF0F675F8632" modified="2018-01-31" version="1">MRGARPPNTSCGCVLAAYAGCADTQTTHAHVLCTLLTSSECCDPRMRNSCFPAENIAETTFRRHPADGAPLWRPGLPSSLSRSSLRSGLHVLAQGTTPPLNLSSSLNPSASQPLSLASPQHAQQPEPHTGGPSSGPGSLLLGLFDCSALGSQGQAAQGQAHAPPAVSLAVLPPLSLQPPPPPPPPLLPQPRPTAAATAATPPPSSLSTDTTTLELCDPQRIKEEASEETSVHAVAPTPDTTTPMSMSSAPSVRPYPLPLQATPSAMKAGMAPVPPSSIPIPMPPPGLGLPLVPPPPSPMLATTPAAAHLDVNSPLLCLPSPSPLIAPPANASGDLSLSLKPESPIAHTRRAARTPPMLVRSTQAQHTLAVRLPAGLAPEMVTISAKKGARLAVVADLWHREDDSHYEWEVVFSPADVDMMSVRAVFEADGQLMIHVRRRPAAAVTGGEGFPPPLVCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNU1</accession>
    <name>A0A2G8SNU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNU1"/>
    <dbReference type="OrthoDB" id="2756178at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="3"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="57745" checksum="DF780974AAE368FF" modified="2018-01-31" version="1">MRPSWQSIRINTLWFASLVCALVSALIGILVKQWLREYMTEVSLPSRDIIRLRQHRFDGLVAWNVPGIMAFLPILLELSLILFFAGLVDFLFALQPIVAGVVTSIVGISLLFYIVTAITPAFSRRCPFKSPQSWVAIYVCKVLISWIHQLRSAFDAVDDGGQSWITRPRQLNFKSWGDRDIATVQARLDGLDLKAMTWVQTTYIDHADVQDSLASIIQDLSPENANALVFGMIARKAHFTPAILMEQVRSRSCSHLLRDAGRNFDKRSQERTVRMLLKLLRLPSHPRDHDPSRIGRLDMLWTLWEFSLGASKAEKKIPSFVVMVLDGVTSLIRRSEPFPLRRAALNLLCEGTLAIPHSYYPPDMGSIILFAKDCYRQNLRDLFMKACAVILFPHGIVRREGEYHKQQLRELLRNLSTFLVQCNEDGAAFEGSSADKLVSGLSALVDKEPSLVEPALLDALLEGIQLGLLQLSQKEHLLLQGMLKFRVLERPHGPAQQAERHPRARPTEGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNZ8</accession>
    <name>A0A2G8SNZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNZ8"/>
    <dbReference type="OrthoDB" id="10448565at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="192" mass="21150" checksum="12B0727BBE28FCF2" modified="2018-01-31" version="1">MAALTPMPMPIPIAKLSPPPPSNAFARKAGFADVTFGPRRITFSEPAPPHPPSSPSSPSSPSPSSSHSHLGGHARSSYEPGQQAPAARPPGVRMREIYEHGSTVRRSQWVEAGDERPLAPFVDQQVYEIIVAIWHYYRAIPISKAYKTDRKDGLALAVVVEFTQLCPEYLKYRLVALNRMLGNAYWVELGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPK7</accession>
    <name>A0A2G8SPK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_02420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPK7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPK7"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL35690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="270" mass="29656" checksum="E50DCAA582D6712C" modified="2018-01-31" version="1">MTGSIAYISDIGAEGLKPLFITGCSITAACFVMSLVVERWLRYRGRLVPTMRRRERILSTLAILGSVIGGAGLILLSIFDTKRHHSLHRTFLLVFILGVALSAIFTIAEFHFISRDFEEIRRLRYAYIVKGVIVAVLILLAIAFTVALYTASNAGAVLEWIIAFGFTFYLVTFIWDIRMAKGIQAGELRRERLLAVREEGQGDQVMREASVAARRVISKLLPKRPPGNATGSGGFSQIVNGNAGQERSEDDAPVGGVTFPQSTYLPPGHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQT0</accession>
    <name>A0A2G8SQT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQT0"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017771">
        <property type="entry name" value="Cyanamide_hydratase_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03401">
        <property type="entry name" value="cyanamide_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="65"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="19734" checksum="74E3AD182586A52C" modified="2018-01-31" version="1">MSTDWEKYGFASVARDPEVLFRDHPTASGPNPRQDLFTAEDFPLPATALVQEVRAFAQKELDEQTFNHSNRVFVYGSALVKTHFPQWKFNENAMAVETYALSCLLHDIGTAEKFLATTHMSFEFKGAIVARDLILGLGGPEPEADSVCDAIIRHQDIFVKGYEDRLRARGLLHACC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRU3</accession>
    <name>A0A2G8SRU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRU3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRU3"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="90004" checksum="225F44729B996543" modified="2018-01-31" version="1">MPPRLNKRQLREQEELQALQDPANDAPSEDQSEPESPVAPAKPPLVGFAALVGDRDHDDDESVEEKEEEEGESQARASKSKKKKKKKKTVNISASTSSPLPEGRSPEPPHDVNDSVPSTPAGPSKKERKALKKQKAKQKQKEEEELDDVDKALAELSVKYPDLKPQLTSSSGPASSPATARSLATLLSVSVQHLDSEAELRKFFGSRVISAAKGSSSSASTRQSVATRSNLTRPQASWWPAQFREGLSVRQLTDEEVSEGLRRHLRQPLHGEKVWTVEYSKKYRAVTFDFMRTVLSGDPEGFWQVLRILPYHADTLLQLSEVSHHREEHSTAADYVDRSLFTYERAFFGAFNYTSGANRLDFDHVENRPFFLALHRQITDLQRRGCVRTSFEFARLLYALDPWTDPHGSLLHLDYLAIKTGMIQWLIELWDLFEPELAKETTDSKSPYMRRIVPNVLPGFAYARALALFIREERTDDRLHEESTPALEDAIRRFPSVVPVLADKADISLSASIRSHAAFRIHTDSSMLLSDSHAILHLLSHLYAQRSASFWKSSARSAWFAKAVSAVLPSLPKSSPAPPKAFSARFDSPSLAYSIYRHVLVNEATCRSLFPFLPRAVLDARHLACDPLPPPTRANEYDAEFFRGVEDVLAARPRSRRQEARLLERLVPDAAFRAQLAGFWEAHPVIQQRFPGGSCTARRGDAGGLPDGEFMVDFVDPEDDEDDVEDHPQAAAVPVRPAVQARDAVQDEDGEEDDEDDDEEEEIAPLPVRFLRSVINRFWGGGNAGNEDDSDEEQNQLRDTGGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS68</accession>
    <name>A0A2G8SS68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_00320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS68"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS68"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="96"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL36631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="182" mass="20738" checksum="1E7E8C398E3C68BE" modified="2018-01-31" version="1">MTNPIWVVKVRMFTTRPDDPTAYRNLWHGFSSIWRNEGLAGLYRGTSLALVGVSNGAIQFMAYEEMKRWGFDRKKGQFAKAGKEYTTADDKLSNTAYTMMSGASKIFALASTYPYQVVRSRIQKTWIEEGIRGFYRGLGTNLVRVLPGTCVTFVVYENLAWLLRSTAVRRDRRRELAADEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSS7</accession>
    <name>A0A2G8SSS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSS7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSS7"/>
    <dbReference type="OrthoDB" id="2193813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="8">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="281" mass="30495" checksum="C3B0BC26A6B814FF" modified="2018-01-31" version="1">MAHHYPPHTPAPGYQSYPGTAPTAAYGYTAGYYPGYPPRPGAAGYTFDPASAGASAYPQGRPPTAPEIPGVSADLASKALHRLVSVEMRDAGFESAEGGVMRRLELELASFIEQLYERAHDYANLANRAKPVVTDLLSASEDYNLEPSEIRRLTKKSRKRKRGGDGPVALLPPPTRSPSPELLSSDDEGVPPAIPITLRPLPHYVPPLPPKHTYLRTPISPPKKAALPSLEKKLKNAALVQESLKNLLLDTEDSTTEDAELLGATVNWEAATHPRKRWKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STA5</accession>
    <name>A0A2G8STA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STA5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="140" mass="15386" checksum="847DD927EC0BA835" modified="2018-01-31" version="1">MFRLRPVSCLLSGSRLSCFVRSVRSLVAVAMSYPSLKEPSSSASANYSSTYRRRSCISHRVSAPNFPLPTSPLPRFCPPTPCFTPSHPGSPTSPPDLLSHTPLHTVSLFATPIPSHTTEVLLFELSDNARIMLSTHWAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STF6</accession>
    <name>A0A2G8STF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STF6"/>
    <dbReference type="STRING" id="1077348.A0A2G8STF6"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="7">
        <location>
            <begin position="73"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="202" mass="22525" checksum="90A699BBB88A6575" modified="2018-01-31" version="1">MGGLKGLAGGLAASIPAAYYLQHKSTYYRNLQPSLKALGIILVVLPPCVISAEKAGIAYEQKQWKDVAKMDLDVQQRRQGANWDNLTPRQKLSDFVRRHEYGVIVGSWAVALTGALRYALKDPIQSITQKVVQARVWAQGLTIGIIIAAGILTQAQRSRVYEEEDDRGVRRLPTDHSWMDVLQKREKEKERAKSGTLTANEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STU3</accession>
    <name>A0A2G8STU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_00866</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STU3"/>
    <dbReference type="STRING" id="1077348.A0A2G8STU3"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="37"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="354"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="658"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL37174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="709" mass="77566" checksum="8D3638FD84FF311A" modified="2018-01-31" version="1">MPKQLSKSPPPSPIGERKVKSPDQWPYIPSSNPASQYTLLEKLGTGSFGTVYKAIHNDSKQIVAIKQIDLEDSDDDITEIQQEIASLAQCDSEYVTRYYGSFVVAYKLWIVMEYLAGGSCLDLLKAGVFSEAHIAVIMRELLLGLDYLHNEGTIHRDIKAANVLLSASGKVKLADFGVAAQLTSTLRHTFVGTPFWMAPEVIRQAGYDAKADIWSLGITAIEMAKGEPPLAEYHPMRVLFLIPKAKPPVLEGPFSLAFKDFVAQCLTKDPHSRPTTKELLQHRFIRNARKTSYLTELIERYHDYRTRSPARAPQYYQATIRNSGAWDGTLRSEWDFNTIRTTSAMGSLRSMAKDLMPPGMEPDDDFDDLHEEDEGSFEGNTIDTTAATTKGSDVPLQPPVPAPLGGLGMNADAGHSTVVIRAYPKGVATEKDPSLMTDSGSDETSGSPAPSTPSQSAENIAAQIADAVEPPPAYTGSMRSSRRSSYAMRNNVTTGTVLGEADIGTGVDTIRPVKKVDTVRSLRLSEEYVGSLRSREGSTSSGASSPSSSKGSHKRGSSEAQAAGRSIVDDVLLPLFQKATRDDMDAREIESLSMISRGFEELRDVNPELAYNIILDILSGINDNPAVRSHIQTQRTLFPHKRIIRKSEMTAKGLVVTEEEEISGLPSTSSPIPPPTQPDTGSPVRKSPISELLYLRWLEGLKLKWPSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU35</accession>
    <name>A0A2G8SU35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU35"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU35"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.150">
        <property type="entry name" value="Hypothetical protein ph0010, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="246" mass="27392" checksum="429185093EE9A02C" modified="2018-01-31" version="1">MSIVESELAKPGAEVEQFCLPEHCFHSFDALFCALTSSKPISANFPDGTYPLFVTWNTRSSRPGRSPRLRGCIGTFEPQPLRDGLAEYALISAFRDHRFKKIEEWELESLECTVSLLMDFEDAASYLDWTVGVHGIQISFPHPSLLAISPSPSSAPSPLSSNSASALPTRASLKHSFSACYLPEVAPEQGWDQLEAVDSAIRKAGWSGRISEDLRRAVKVRRYQSRHCTVSWEEYARWRTAHGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLB6</accession>
    <name>A0A2G8RLB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLB6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLB6"/>
    <dbReference type="OrthoDB" id="2798231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="128" mass="14758" checksum="4E98E782D0867E53" modified="2018-01-31" version="1">MVLVGDLHILILGKVTIYLDDILIFTNDIEEHRTLVREVLKRLAERDLFCKPEKCEFEQPKVEYLGVLVSENRVEMDPVKVKGIAAWPVPQNASDVRKFRGFANFYRHFIKDFSAVCKPLDRLTGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLQ4</accession>
    <name>A0A2G8RLQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLQ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLQ4"/>
    <dbReference type="OrthoDB" id="3242181at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46997" checksum="0ADE0C09A5B0E143" modified="2018-01-31" version="1">MSTTSLPSYVAPPTFTRTPTYSAEPHAYEQRLALNRPAQRPAGSFVKQSKNVSLRLYAQEDNASLPVYGCGAAVEGSVTLSKVEGVTAVDVKIEGSLILREVGEGGTTTYKLCLDTVTLWNRNTDPESCPTTLEFSLNLPTTFSDGKDTYPLPPTHDVHLSGVPGFNATIEYMVSVSVAKGSRASSLLLRMGNGNVSTPFIYHPRSRPSVPLPARMRQSSETFKFIPNPEWNCHESVIRTRQAGGKDVVCELYLPASRVFSLTQAIPFHVVFCSSAFSLAAFMPYGPTATILAPNKQFTRLRVLRQSTVDVRNELVLGTKTDIWRVDTIGEGDFKHAGDGHEWLCFSGEIQLDKDVKVGSFKAGGLIVRDFLEFTMHPPEPAKAPFKEMRLVIPIRLTTDPWSVDSMTSAVVDDWSSPPTPPDLAYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMC0</accession>
    <name>A0A2G8RMC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMC0"/>
    <dbReference type="OrthoDB" id="2751671at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="187" mass="20039" checksum="76B13D005A3AF3C5" modified="2018-01-31" version="1">MSQTGPSEASDSTGSKSTAQSLSAELDKLTTAVLEVSDNVQACAQESDVRHAAYRARAEEQKQRTTSFQDQIAKMVAMTQEGLRREREEPLKVPNPEKFQRNLQRAAFGTGGDSESASRSSMLESSRDSMSAESRTHSVRESQADSGLQPGDYPTGSPASVRASCGSSPVSESQSGILSDTSSWQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMR4</accession>
    <name>A0A2G8RMR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMR4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMR4"/>
    <dbReference type="OrthoDB" id="3215905at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013607399" evidence="2">
        <location>
            <begin position="30"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="635" mass="69332" checksum="F6EC3DAC1332DE50" modified="2018-01-31" version="1">MSSGAQCHLLSRCSLLVSVASFFTSLCVSESSKAYPSVSKIPSDEQITAALSPLQPSPLSQDEICCFFSGLPSRPLLIARTGAPWKPIPRGHWQCPYDRELRPVGDHAIAAPGVWDNQVGPALLKVLDEENVKWDTIDVHRIHYTEFDHEAPFPVVVCIGVKFGALSGEDGVGVAKRCQAVLDGFGLGDVEVAIKASARFQAAAPAFEKPVRRWVGDKSPVDNFRMPFTSCVGFPLSSAAHPGVEGSGGFFFTNGEDASKVFLLTARHVVIETTTRDKNVVYDHESSGAEPRRQNATVFGDKGIFEYMKSLRVELGSNSRYADLCRRWIDDAQAENDKAQGQDEKAASAREANRHQLELEEAQAAVNALDTLYVDAAKLYLSELGRTLGFVSYSPPIGFSLGGHKYTEDIAVIEVDANKIDPSTFRPNALDLGSGEFGIGELTRLMNPRGWKLGDPASFDHHAIFDCLQLRDIIPDAELRDPKQTDFNGDRCLVVLKRGKTSGLTIGRLNNVPSYTRTYWEDGTSDVSMEWPIFSVRYDTVKKPVAFSEPGDSGSVVVDGKGRIAGIVTGGAGFLNSKLDSRATLTAHVTYMTAAEFIRDQMRTRGIDMNVNFTLKQAPDLPVSSDRGIQDQEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNH4</accession>
    <name>A0A2G8RNH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15564</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNH4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNH4"/>
    <dbReference type="OrthoDB" id="2690521at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="392" mass="42403" checksum="993629A4DEF66CC8" modified="2018-01-31" version="1">MNTTEKSPGNTWRNAMEGELDSVIALAISPNGKWIASGSRQHAILRNAAMTAEGGQQSPDMVFEWIAPMDNDPYTRPFTFSPDSRVLACCTRDPEGFIQVRDVLTGNRLAVLRVPAGARDGLDACRASCVWSSNGETLTSVVFIPSQHQFLVQVWNAENYRLISTITWTTSFHSPSFLYSPNGRWLASFQTAGNRLQQSPPVTSMEVAGACTVLGAPLTGIPTACHILTATFDQASTRFAAVSSNHILHVWSLSTGAKLLQVPMNEYPNDSERLALAFSPDGTQLLSCSGGRGAAFVLTLRDAASGRTLLPRRPAYHFLRGRTAPRFVFSDDRTHLLSASADGFVQLWRAGDAAFVRDVVRDGDAPTAFAWSADGRVLAWGTEGGGVVVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNZ6</accession>
    <name>A0A2G8RNZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNZ6"/>
    <dbReference type="OrthoDB" id="2689908at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="658" mass="73210" checksum="AADA30A15902AE5A" modified="2018-01-31" version="1">MSLACIVHSALSELSERLDLRISPLSSLFTETVARILLPSPFPDVEPAISALLERGVKLICFQPHSSTTMRHYERVLPSAFREHVELAPLPIPVHFAVRDEPWWRMFLHTGSRSRGSKLPTRSLSALSQWALRANWDGDEGDPAPAFIFVVSSQPSPYPLVNASLTLGPKLAHDTGVLCEHPTALRTTGPIMTENKNVCCPLYLHAAPMISINPYCRPIVEWFHYRLDAWSLEAFIRIAHELFPASQDFRERQKRSQARSGGPEGVEPEWSSFDGGNSYIIGGRNDPRTFVFKFLKDPYPSLEGPPTIYEEIRLYKQLCKDYKWKGAQKAIDWVANVRKESGSVLPCLPTVIPASPPIEDPSWAADALSLLHKRYPPTDTEAIDCDSDNESEFVTESFPRLTPQFSDVAAPSCVKVVVFDVFGVILDREGAIRSALTPWTMVSGCTKDATQLTRLYLESEALADNDSSTQPTSLARIVYSALLALAERLDLPISPASTLFTDAFTRILTPAPFADAEPAITALADRGVRLICFPSHSSTTMEHLRPMLPAAFHKHVEFAPLAMSVHFAAGDQPWWKMYDRCRETAPDVWEDEFLIVSAGVGRVLLSAIGRRYATALLKRPDSLESHVEFVIGERREHNPIPVMTVPGLMELCATLGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ65</accession>
    <name>A0A2G8RQ65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_14962</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ65"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ65"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="107"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="383"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="626"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="655"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="685"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="722"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="756" mass="78371" checksum="0FC00AF0A73A7397" modified="2018-01-31" version="1">MPAADPKRKDHDSVSDSARDPADRDRDRDREKGPKHKQSAKTKDLSHVPCKFFKVGSCTAGSSCPFSHHVLEPGQQKEVCAWFVKGNCKFGHKCALAHVLPGQSMSMDRKNKKAAQLAANAAAGPPNKDGQKHSKPHRASHHPASQPSQSRNPLLSGSTAPTRAMPSNPRAPISMPLKATLSPSAPAPPVKDTDFVSFGLPDESNKLPSAPAQGKAPSTSTPDPDNPASDQDHRSTHDPSTHDPDSTPDSTFPAPLPTHTPSAPRRISDASPPVDFGPIGSPPRASSSSSRPARINGFSPGTSPQPQGLSTSPFSAPGAQSVFNLPRHDDAAGDFKSRSGLSASLGAMNWGSDRIVSRRIGLEEVVVEDEDLEEFLPSSLTDLLTPEERSRRMSRTNATRPNVGLERDSSAQRSAADAHHRYSRSVPAPSLLQDIKSIWADAGGPPIGSPDAAALGTSHLGGGLGNGTPSSFTSNSGLAPRVEEMLSPSNASAAFLPGLHHFINAKTSQRPTLASGMSSMYSTGGAGTHNLSSSAYGVEFNGVPMSPPHTSTYGMPPPNDAYLQQAGRRAGGRTGAGDGFVPGMDDQRSALSPSSRALQAHAPGQSLPQGLAAGYSRIHALPPPVISSPSSSSFLSRTPVGGGFSPGTKGLGHGHNTSGDWASMSPTASSLLDQINNGLPSQPVTPAGPGAPGTSLGGLETMFSRLSYSAAASRTVAPSGMGTRNPSGRSGHPQGSLSPLSGPVLTGEDDDLFSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ73</accession>
    <name>A0A2G8RQ73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ73"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="89" mass="10376" checksum="734EEDA062A131A2" modified="2018-01-31" version="1">MVEICLYTHTVTVTTYLEDIETPPSFTFTSDYKANERIFQLIRTNYSGWVDSQVHAKLMQAFPDAYDSYLSGEPFFPFWEYPDLAEVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR63</accession>
    <name>A0A2G8RR63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR63"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR63"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="238"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="464"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL23999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="786" mass="86418" checksum="868153E20B25F1EE" modified="2018-01-31" version="1">MATDEQLKAFVTRHHQLLDKEREAEIERTSLLLSNCPPKLLEQKGLCLASLSTASVRIGLGGKTLVELERPTAYHSSPLFPPHTLRPGDLARIEEHTSGAAAPKKATKAKKPGSTDKGKSDGVEGVVFKVSDTRIVIAVDPPETGGEDLDLPDRCRVVKLANSVTYDRMDKALNRLEEVVLPNSDAKGDKFMPKMTPLVRVLMGMQSPSNRAQIKDLKFFDQSLNSSQQEAIRFALGSPEVACIHGPPGTGKTHTLIELIRQLTGATPSNPKPLRLLVCGASNLSVDNILERLLALPASEDGKKLKVTRVGHPARVMNQEDVIEATLEVKASRSDQAILAKDVKNELEAALDLLSGKGKGTKGKAPRGMERKKMWEEVRALRKEYRQREGGVVESVLSESQVVLATCHSSGGRQVRSQEFDVVIIDEATQALEAVCWIPIFKAQKLILAGDPMQLPPTIISIDKGKEAQKSPPSSTAKPSMKPGTKKLASTLETERGKASETEAESGDEDTHSEEDEGDLELAVESEEPSQSTPRNPRKAGSKAVLRPPRTLETTLFERLEEMYGPGIKRMLTVQYRMHAHIASFPSKAMYHSRLKSHSSVEVHLLRDLPNTKADSEDDEKEILGTPVVFYDTAGCEYFERLEGDRDEGSRCNENEASVVKMWVDQLGSAGMLPSQIAVITPYQAQVTLLTSLLRPVYGPELEIGTVDGMQGREKEAVIISLVRSNEKREVGFLKDKRRLNVAMTRARRHLCVIGDSSTVQHGSPFLKKWMAWLEANADVRFAGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR72</accession>
    <name>A0A2G8RR72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dipeptidase</fullName>
            <ecNumber evidence="1">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR72"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR72"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000180">
        <property type="entry name" value="Dipep_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00869">
        <property type="entry name" value="RENAL_DIPEPTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="444" mass="48657" checksum="243EBCCF155033D3" modified="2018-01-31" version="1">MSNLQNGETAPLLGDVPNLARNVHLDEAANRSRRAATVRAVTYSVLSLVFVLALVGVFAFWDKVTGVVGRLPKDPHKAALLIMERAPVIDGHIDLPILVRFAYKNNVSAVDLTKPFDGHVDIPRLREGKVGGFFWSVYVDCPTKEEESDNFLKPTNRVRDTLEQIDVAKLLISKYSNTFAWTLSSQDIKVAMSRGKIASLLGVEGAHQLGNSIQTLRQYYDLGVRYMTLTHACHNAFADSCGMFPALEPRHGGLSPLGFSLIQEMNRLGMLIDLSHTSDDTAKQALKRSKAPVIWSHSSARAVNNVPRNVPDDVLELIGTSPNRTDAVVMINFAPIFVAPPGEANVKWVADHVEHIAKVAGKKHVGLGSDFDGIGQTPDGLEDVSKYPALVAELYKRGWNTFELAGLTGGNLLRVMEAAEGVAARLQRSGMEPVMARYEEREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS27</accession>
    <name>A0A2G8RS27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS27"/>
    <dbReference type="OrthoDB" id="2743427at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="11139" checksum="63279FA89C384FD1" modified="2018-01-31" version="1">MAFFKADEKTLACDAWPGEIGRVMLERGKKVFPRHKLVPCDIEEVPTWLCVETDPDKGKALVMFRTDVASDMQGDALPITVRVLGILTDMDLSLDGDWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTL7</accession>
    <name>A0A2G8RTL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_12749</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTL7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTL7"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="16">
        <location>
            <begin position="141"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="17">
        <location>
            <begin position="415"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL24862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="867" mass="94707" checksum="CC08DF833E651E71" modified="2018-01-31" version="1">MGTGSIAACFGASLRRRTILRIQSALCYRLILSKPGLPEPVTDLFNPVTSLPQISEAQILAHAKYLSEDIGYRTVGSAEHAAGDAWVLKQAETLRGECEELVRANPQRKLQCEVWHQQGSGSHRFDMMGRRLYKTYVNLTNIIVRLSDGTEEGKKDAVLVNSHVDSTLTSPGAADDAMPVGVMLESLRVLIHTPDWQPKHAVIFLFNNAEESLQDGSHLFTTQHPVAKTVRSVINLEAAGTTGPELLFQATSEQMIKVYAKVPRPSGSVIANEVFSSGIMLSDTDFRQFQLYLNVTGLDMAVVGNSYLYHMRKDLVENIEPGVAQHMADNVHALLLHLTSVDSPLPELASTGYTKPQTVFFEYFGYFLVYSFTTAKILYTASFMLALIVARWTFVNPAPALKKGTSFLGEQIKGIVATSGAFIGAAVGVNVVAFIMDKVLGKSFSWFTSVFAPVFLYGPAALSGALASQLIVDRVPEQTTFSSIMVVQSFLGALVQLLGVGASGTLFLTSSPLIPALVLNAVLTSPGDDISLWSYAIGQVTPLVTGSTMLFSVLDVFVPLTGRIGEEAPSEFIIATVVGVTCSYILPLTVPFVQRFSRRILIRLVIFTSIVTGMAMAVFCMRSPFDAMHQKRLYVIHMENITSAEQHLHVAGADGAPGFHTLAADIAKEFSVPGVTPTTVVMDDWNSDWDTVYPFSAFLTPYKFDLPLRPEHQDPLDPDFKVTAINDKIDEVAGTRSFTLVVTHPGIIWTAVAFDAHVLKWTLDNHPPDEYARHHIKEGSFYGHDTWTMDMVIKLRPAHDGASDDGSVKVNFMGIHEKAMWPGKRAEKALGGRAMKLFEELDGWLERETGGTVEALLIGCVGGVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU89</accession>
    <name>A0A2G8RU89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU89"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU89"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="334" mass="37585" checksum="FD1A9F698075E760" modified="2018-01-31" version="1">MAGLISPKPVPYMQHNLQYNPYQRGVQAYPDTPATSIPPLSHPTPHQTVFLPGTTVSNAPLTLNEETKIYALVIDLLDSQTRESALLELSKKREQYDDLALVLWHSFGIMPALLQEIVSVYPLLSPPNLTAHVSNRVCNALALLQCVASHPETRQLFLNAHIPLFLYPFLNTTSKTRPFEYLRLTSLGVIGALVKQNDNTPVIHFLLSTEIIPLCLRIMETGSELSKTVAIFIVQKILLDETGLTYICHTYERFYAVGTVLSNMVNQLVETQAVRLLKHVVRCYLRLSDNLRAREALRACLPEPLRDNTFNALLKGDMVTKRCLTTLLNNLNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU90</accession>
    <name>A0A2G8RU90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_12975</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU90"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU90"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="40"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="387"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="219"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL25086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="506" mass="53806" checksum="50DA1ED074462748" modified="2018-01-31" version="1">MLQVQKASSRAAARRLRPSASTQLGRWHQQRGLATPSEPYDAIVIGGGPGGYVAAIKAAQHGLRTACIEKRGALGGTCLNVGCIPSKAMLNNSHMYHQTKHDLKRRGIDVSDVSLNLPVMLKAKEDAVTSLTKGIEMLFKQNKVDYIKGAASFVSPTRVSVKLNDGGETEVEAKNIIIATGSEVAPFPGGAITIDEEQIVSSTGALSLTEVPKKMVVIGGGIIGLEMGSVWSRLGAEVTVVEFLGGIGGAGIDEEIAKQFQRSLSKQGLKFMLNTKVVSAEKKDGQVYIKTESAKGGKEETLETNVVLVSVGRRPYTEGLNIEAAGVELDNKGRVVIDDQFNTSVKGIKCIGDVTFGPMLAHKAEEEGIAAVEHIAKGHGHVNYHAIPSVVYTHPEVAWVGKTEQELKAAGVKYKVGKFPFAANSRAKTNLDTEGTVKFITEAETDRILGVHIIGPNAGEMIAEGVLAVEYGASAEDIARTCHAHPTLSEAFKEAAMTAYGKAIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUB8</accession>
    <name>A0A2G8RUB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUB8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUB8"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCZ1/INTU/HSP4 first Longin" evidence="3">
        <location>
            <begin position="10"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="670" mass="73827" checksum="48CC709CBE690CF1" modified="2018-01-31" version="1">MSRIPPSLLYLTIYNPTLKPAFLEPDNEDAEEQAHILFYTAREHAVSRDRILRQVGLAKALVNFSEMFNAGIPCENVHSQGRRMVMISPEPNFWIHACYEVAKTPRPHHNSKGKGTPKAKSKDKEKETDQTSRPTTIYDYLDGSIHDIALRTHFQRGYAEFKLLHGSFDSILSNVGQQALELQLERFFTVWAWKWDIEDDDFGTHLGIPLHPSHAKLTPLLDKFASSLPDELMTFALSPPHIIPSRTPRYPAALIRHVLARIPPPVTPVPKAKQTIPSSTVTAPPLAAQMGKQTTSADVKSPPPQTESGFAFPLPPMPAMPNMTFGLDVKSMKWGWPGYLTFGKGGGTPAGPSGLSSLTAAPPNLEAVIEGQNDLPKAASTDHSPRPESHRKNTLDVDTASLLEAISTESIGSYSRTPSPAPSVLSKSSQLGELSTETSVSTGGNVSPVDDADPLEIQVNGIPQIVFAQPAPELPPLQITARPVRSFLWSRVHLDSPDDPSITERCRVLHLTHHEFTVAIVAKEDHSLDLPHLVDEVVEVIETMQASLTEESQEGESSLPSAVKILQPKDRQIVSKDEFTYSPSPGFVSRSEHLYNGQELLRSGLDVYEVFSRGQNPQHWHIGKRGLGATADGEVYMEVGRKETTLTDVDNELAGVVYHMDLWELYQTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUE2</accession>
    <name>A0A2G8RUE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_13025</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUE2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUE2"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="568"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL25136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="588" mass="65121" checksum="EE1F2E9FCDD6B2DE" modified="2018-01-31" version="1">MASSTSSSSPASSPPLISPNSSTASMASSASASSVVAHGAVYVSPPYRSSAQKKLRAMVTFAPRKSLFDISNETSTSNQFRGFFTLFWISLFLFTVRTYVRSMETHGWPLNFEFASMITSDGLTLALSDAVLVLNTGLCVPFAKAVSKGWVNYHWAGLVIQHLWQCAVLFVAITWTFNRRVSGFLTLHSFVMIMKMHSYLSTNGQLGQANKQAQRVLAQLKVATDTVGGWDAALQKAESAIVQAESPVQTGTPEVPEDAPAGSTTSYVDARTAVTLRQRLHRAVVSANGQATTATANGVKATGADANVDSAFGPGGVPTYPPTSSEILTHHPDEAVAALAKHHVELERELTGPVEGKVRWPANITLRDFAWYQLTPTLVYELEYPRTDGIRPLYVFEKTVAFFGTFALLYTIVETFIIPLTPTPDQSFARSLLDLAMPFMLSYLLLFYIIFECICNGFAELSYFADRQFYDDWWNSTSWDEFSRKWNKPVHTFLLRHVYASTMSSYKLTRQSAMFLTFLLSAAAHELVMAIVTKKIRFYLFVMQIAQIPLIAIGRVPAIRRNRLLGNLVFWVGLYAGFPLLCVAYCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUP3</accession>
    <name>A0A2G8RUP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUP3"/>
    <dbReference type="OrthoDB" id="2564465at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="401" mass="41811" checksum="464D3C5C107E02E6" modified="2018-01-31" version="1">MGSVQSYLPVAAVAAGAAAYGYVQLNKPAAAPQHAGPSSSSAASAYTSAASSKKQKQKKKAGTGAGAGTSEKGKDAHPAEPIVVPFPPVVPGSFDTQSPTTPSEPQPKPKNKKKKAKKTGGGGGDAQSESSATAPESSAAAVRMTKPKKGGAANKPAALDNDGWMKVETKKKPAKPGAAAEAAEGSGSQGQGLEVSTSDLATSVTTGNSSPVTERTEDEGHLADSVSSENRRTLAEKLLPKPRKTGVEDLLEEPDYPEVSRVMRIKPQPDEQPAAGFSWADYEDVDSRGNADDADGEDDDGWGVVKSRGRQRANNAPSATSAPTVQKSTETLTKKQRQHAAKREAQKAAKADAEQDRLATLAKHKRELERARMDEQTKATKKTASGGMSAYVDENGKLVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUU3</accession>
    <name>A0A2G8RUU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUU3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUU3"/>
    <dbReference type="OrthoDB" id="2753634at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="165"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="343"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="558" mass="63025" checksum="4C1F5F22E06325C0" modified="2018-01-31" version="1">MRLVDTETGEFVDFVDLERTPPYAILSHTWDKDGEQSYQELVKIQEKYKPQCPPSEEHGSANSHSDDPTAVPEVPTPSEERTTSSHSPLLLFQGNPGSCSVWRRLGMGRARIFSIIQTWLCCTPDLTTLPELETPSGPGALSDPELPNDIQTPSSPHTTLRSIWDPDSGLSEKVRRACEIARRDGYRYIWIDSCCINKESSSELSEAINSMYNWYRAAQVCYAFLVDVPSNEDPRAKKSMFRRSRWFTRGWTLQELIAPLVVVFLSQDWEGLGTKDALAEVVYEITSVDCGILAHEREVSNESVADRMRWASARKTTRVEDEAYGLLGIFGITMPTLYGEGQYAFRRLQEEILQRIPDQSLSAWGYECPSSIQTLSNTDDRVGLYETSQTLLAPSPRSFALSRGRMIPATGASIKPLELCIEEYIHTRYGIRTQLCVLPLEALNPELAVPDLEQRWYLVALRSQHADDPQRLLSRICYHPRRAKANVEFLYVAQLNMPSELHPDGRPVTLFTVSLDDLKRVTNTQIQPKTVYFPHRAFCGQTTAQGREKAKAQVALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV28</accession>
    <name>A0A2G8RV28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV28"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV28"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="30122" checksum="0870C88CA4EC24A1" modified="2018-01-31" version="1">MNVAWLVLGVWVWVAILILRLRVFSTLPFVKAVVLTQPYFNQWSNLKAHAYTLPIVSLSLSLGAFADLLIAITFSTYLLRGGNQYSHASRTLTNMLTLYAINTGAATVTDGSLVKHHLCYLRDRGMSLCTRWQGLARPLLTTLVAKYGSVRSSLAFLVLSEMGAKPADAPAPPSLPVRPTGISVYANSFLGSLNFRAFLRHKNLARGFSGFRPSTNSDNAMDVQFGSFPSEDCESPPLAREPPVLMVEFDGGTVCEARAPGSESCVSGGDSAMKAGSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVA3</accession>
    <name>A0A2G8RVA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVA3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVA3"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="651"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="685"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="896" mass="98345" checksum="0EDDC6AE10FEA3B2" modified="2018-01-31" version="1">MSSPEETTAPSFKKRKLQRACDYCRTKKIKCDGSDMPNNRCSKCISRRMECTYLLGQNNNYPRSYVEDLESRLERMERLMNKLLPDKDIEKELDDHASDRDLSNALTPASERSHASSSRVEIPRTPSSLSVVPPTPPSAADVSQDAQSDEEEEEATELDKELAEGMRKLSMHSPPQRYHGKSSGLVFIRSAMALKNEVAPEYPPPPSRDGQHSWLKNFVENDFPVLPSSAFPPPDLLSTLVDLFFAHMNSHYPVLHQPTFTASIAAGEHLRNGGFGATVLLVCAIGARFTRPEQEPRVLLDGEAHYHSAGWRWFLAVAGMRKMSFAPAKIYDLQIYALMALFLQGSTAPQSTWPVIGAGIRMALDVGAHRKKMYSPRPTVDEELWRRSFWLLVLMEWMIGYGLGRPSSIHDEDFDIGLPTECDDEYWLTPEGEPLFQQPPGKPSKVTAFVCMLRMCQILAFAMRTIYATNKSRAQLGHADQQWEQRIVADLDSALNKWSDSLPAHLRWNPEEENVMFLTQAGTLSASYYYTQFAVHRSFMAAGRRDAPMSFPSVIICTNGARTSIQILETLYKRTGTPNHRNMGILLVSGVVLMTNIFALKRSGRAVNAGKDLILVRKAIEMLRSLRYEVHVAESLGEMLNELVSAVKDPRAAPQRTPISAASSPAAQPTEGPSTSQQLTAGDVSSAHAAPAQSTTSSQAGETPDMPPGLEFMDPNHPLFGLAFGPDGIGPFSQDFAGAGPSTFAAPGAGNQQPSLSLSAPEHEYGFLHPHDPPASQPRASASQGVGVGMGMQGETQFDMSGGQMFGLEPFGYNESMSMSMSFLPPGTTGPEFSQAQQQHTNAFGDSDPGAMGPGDHVDTDFVLMDDALTVWENLPPAVGWEEWGAYFADTSNAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVR5</accession>
    <name>A0A2G8RVR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVR5"/>
    <dbReference type="OrthoDB" id="2757163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="220" mass="24175" checksum="6710679C97B6CFD2" modified="2018-01-31" version="1">MPPPSNHTPPWDHWQGGDSHPWNHDSLHKLFPDILWTAVAISTSFAVLYGLFLTLAVVSVYLLLRRGVRRRPLTAIQLFAVTALLVSTTTHWAVVVLERFGGLLSHPATVTVLSNKEAFLPEECVGTATLTVNLVLSDVVVWWRVWVLWKDSRVLYRRIVPVCAGVLLVATFVTGTVDTNFACHAKGGFMYEGSPVGTAVLVLSLATNLAATTLTAYKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWM1</accession>
    <name>A0A2G8RWM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWM1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWM1"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="152" mass="16647" checksum="88B2A8336F899314" modified="2018-01-31" version="1">MGSQQAGFYVEYILGMIASTTNDTVIETKRVDGVVFAGGLDEKVEAEGLDKVAVWFGNRLDVVAQLAEMWASSWLSHGERDHSGQTPTPERRFDTFEHSATLFHILAAKAAPAGRLPITQCPAEYVGQEPVADMTLRPRATNPGHTYVEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWP6</accession>
    <name>A0A2G8RWP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWP6"/>
    <dbReference type="OrthoDB" id="2764780at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="404" mass="45082" checksum="C67B27E09864B8EC" modified="2018-01-31" version="1">MRVCRRWYDVASRHFFAIIPVAHRHCNRFLKFVRIHPELASYITELRFFDKSRGDSGKLLGMQQGPFDIQLLASALPILPNLRIICLVGYGGLVSDQSAPSGLQKRNQSTPVSLLRLSFEHCIGVMSMFPKLLPLFAVNTFVINSMHLATFHHVPTPVVPFEVRNLVIGQGARYSEDQYAAFERILVPGGLRGLGTDGWAKQDIPILERFLRSSTGRDLLSISIGAVLGENLPPPHSAVPVINGPTVCDMLGAALAHCPRLQCFRLGFVHHDYDPSDPLIQPDPFSPIVANLPATLHIWLDTPGLWCCTSTSIGLETVDRTLAPASPSTSGHAGSRFPNLQMVELHVHQNLVWPRMRNRTCAHPHEEREPMPLLRLHAAGLLRYRVGEVELDQPHADIYWPLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXA8</accession>
    <name>A0A2G8RXA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXA8"/>
    <dbReference type="OrthoDB" id="2746865at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="48065" checksum="173FE910340097D6" modified="2018-01-31" version="1">MRNDYRQTPFDELEWWFATLKRDKVLGSPEEAKIIQNTLGKQIMVLDSQNATENLTKLTKDPDWGAHLALAYHTVILRPGVQGRPGGLTQESFFRTVATTLPYMRNVKELILLGSDIDLGPDAATARDLFEGTEMPLETLWCDSKALLARCWASLCTSTAVTTLQDFRGFCDPHEDLPSEIAPPRTPKLKYLETSAQFAFKLQDGVPWGITHLCIHVEWHTLPLMLKKISDLQALSDRLHSLRLNCYASLGIEEQPTKGGSTPRAHRSPSPLAMRTPLLVCRNLRAPVLNYLEIKEITPCDDASLNALPNGLAPHNGTGTRSLRRIAWHPAWNKANGKQSGGEIRNAVDEIFRAVLTVNFLAVALDRHCSGLWRVFTRDLPSGRINEGDWGYAINELSWKVTEWEDAGAKRWHWPQSSQLYVKGLVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXN0</accession>
    <name>A0A2G8RXN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXN0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXN0"/>
    <dbReference type="OrthoDB" id="2729552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="81"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="375" mass="43037" checksum="D293A1135E7989A5" modified="2018-01-31" version="1">MEIAIEQNKAKKEQTFEEMVPEQYRDFRDVFDEATFSTLPERRPYDHAIELTDDAKPYCGKTIPYDPRRTASIRCISRGKPIHGSNSTVEISVGCPVLLCQEKDGKLRPVQDYRQLNTMTKKNVYPLPLMQEILDRLKGAQYYTKLDIRWGYNNIRIVEGDEEKAVFITNRGLYEPLIMFFGLTNSPATFQTMMNSVFQDLILRGKVIVYLDDIIICTSDLDEHKRIVRQVLQILRDNHLTCKPQKCEFETQETEYLGHIISPGKIHMDPGKIKGVTDWPIPTCKHDVQSFLGFANFYRRFIKDFSKIAGPLNRLTGLSEWTWTSEHQLAFEGIKHTITSAPVLAIPNDTDPFKVECDASNFAIGAELSQCQNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXQ9</accession>
    <name>A0A2G8RXQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXQ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXQ9"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="33"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="342" mass="38249" checksum="706BA0F8B3EC4612" modified="2018-01-31" version="1">MDELQADPEGMGGTQAGGQGQRERDAQFWYEDGTVILVAHNVEFRVYKGVLAQHSLFFRDMFSLPQPPNADGEVSCPIVPMSDSPEDVRHVLQACMIPGSPRLTGSELIMRISLFRREEPSFDLISACVRLGHKYHMGQLLGVSIAFLKSYYTTDLDTWQRHWATYDHGKCVQELPVGFTDLHAIGVVNLARLTGETSLLPTAFLQCHVLEDRVFDGFARPDGSHEGLQLADLKRCVKAKGRLAAASVAISVRIYLPSVSEGCTTRDACLAGFQLALALLDWYSDIVTRQDPFRPLLRLYEPPEGLPLCACCVNLAMERGKEAQEEFWKKLPEMFDIRVDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY43</accession>
    <name>A0A2G8RY43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12160</name>
        <name evidence="4" type="ORF">GSI_12162</name>
        <name evidence="5" type="ORF">GSI_12164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY43"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY43"/>
    <dbReference type="OrthoDB" id="2749024at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="585"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL26407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="839" mass="93912" checksum="D56BE30ED293D814" modified="2018-01-31" version="1">MGRGSGGRSVEDDHPTTQRSPRPVRRATQKPPVWEDMIPKERKSKTNRGDDGKDGKKKAVKDKSKSKEKTRAPQRSVASQFQAPSMNTNTSEDEAVGSETAAGKTTKFGKSPKADSTVESEGKPAKKNKGKSRQIIESSSSSGTDSSSDEGDDEEEDESSSSGLEDLEKKDPGALKAKFDGERPAWVDDDPQPYSRQKDPQDESQDNYGFDDQQDGVGSPSGPSFRSPAGSPAPSPLRVNQALIISQSRSRSRSHSYSHSNSRSDSRPRRPRSRSGSRPHPRSRSRSHSRSPRPAPRSSRSRSDPAPAAKHARDESSDEGLKQAPPAKKKGKTSHVGKTPVKTNERNQRTPASDEAKARSREKEAEHDRTRRRARELEKEREKSKRKEQVRRHQAREENNHQRHKEPRSHVREDISGNESSADEDDKGRKKMKPREKAKVKEQVQRTHGRQTSKKQMDASRAGPSDAGKERGRSLVRLRDPDAYESTRILDSSTMMVATQVPTGTAPHCALQNVGDGIVARMLSPLIISNYLMLTFYLQDASDLLSESSDDDDNEDPRIDIVWYGSNRPNLTDQYPRVYRVTRRTIRECEPNVCLLNAFPDEDANFARPLLIKHATTLGYKDMVKKLKSNKETDEFYHRKLCAIASQRVNLIRGKVKKACQRQVKTVYGLTVGDSEKITWLLDGIAYIFPHKYEVFVHKDRTVKGEGAFSLPIFEDMLSDAFFSKKGSFGFRIMPRFTSSDPENPEEKEIPAAMLALVSTAIYASIEDYKHAPYEAGKFEVNSYLHVYKQNIAALDAIKTGNLEAYHALLHGLYTRIVGGSARPVSKKSYLNVAGMTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYF7</accession>
    <name>A0A2G8RYF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_12275</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYF7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYF7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL26517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="521" mass="58066" checksum="A34D191DEC94775A" modified="2018-01-31" version="1">MAPTALILVLVVAGAYIRYTKSVKYHHPPGPAAVPLLGNVHQLPMEYQQRKLAEWGRQFGDVVFAKFFRTPVVVLNSKEAAVDLMEKRSAKYSDRPPFILLKELCVDCPANIAAAVATNPPSPSLPSMGWDSVINNLPYGERFRKHRKWLQDAFTSKAALMSYRPIQRRETYTLLWAGAMVLDIAYGYRVTSLDDRLVETAERTTVETVIAGSPGSMLVDFFPILKGIPLWMPGSGFKRQAFHVKTLVRKTLDTPYEMVKRAMMAGTAAPSLTASLVEEALAEGTLTAEHEEDIKGAAGVVYAAGSETTVTTLKTFVLAMVLHPEVYQRARAEIDRVVGPERLPDFEDREHLPYLECVVKEVFRWNAPVPLGVPHRLNSDDVYRGHDLPDGAMVIPNIWWMTQNPEVYSNPEKFDPDRYLRMSTDESERMDPRNVVFGFGRRICPGQVFADASVWLAAANIIAALDLSFAKNALGRDIVPDAAFISGFVSQPKQFKCAFRPRTEQTLSLIAHMNAVNIVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYJ3</accession>
    <name>A0A2G8RYJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYJ3"/>
    <dbReference type="OrthoDB" id="3217871at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="615" mass="67940" checksum="240DB7068086E19F" modified="2018-01-31" version="1">MALCTAQVPITISLPPSHVYLRYGLDVSSTPGGGRTFSLERDTASPLINTLGRILKDVRQTVEDDPEHFVTTFKLRHRTQSGPVCVHGDQSEAGTFTRSLGPSISRVSLSGVPTGAGWDPLTTADFDSTLDGTYALRYLRMLTSCARAVIHAASPRTLHRRLAAAHVSVVSVLSPPPPAQPDSDSESARCRIAEYVLDAIRHHKFALEFKPPEYRQKACEEAGVNVIEVYGPYGTVGPEPSHWGLCPPRIAAAFSPSRFQLQTMDETPPMKRACTSEGGNGPDSTQTASLQRDKTFWYDDGTIVVVAGNIEFRIYRGLLARYSPVFFDMLSFPQPPAAALSTNQSSDPDCPVVQLTDSPEDLRHVLCVFMAGESLKPLGGSSPSFHALSSWIRIGHKYQIDKLVDDGLAYLRHFYPRTLYDRKHSPRGVSRLVVPKDRPATISGKHAIGVVNLARLTERHDLLPLALLECCKLGADITQGLAREDGTREYLSPEDLGRCFAAKSQLVALNIEACLRIFASARVDYPSGGNEGDTCLHPEMCEGNLKEHRRAFIDYHIRSVSVDCLLAEDREKFCPLQYLCQNCAYYVDDLIEQEQRNLWRALPCLFNIVVEGWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYN5</accession>
    <name>A0A2G8RYN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYN5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYN5"/>
    <dbReference type="OrthoDB" id="2749746at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="333" mass="36971" checksum="D98DCD8F7558BD82" modified="2018-01-31" version="1">MQDIVTFHQPPTIKCLDLWFESGDVVVVAGYVAFRVHRDVLSDNSTVLADMLSSLAASEESNQEELDGCPVVRLKDSVHDVKHLLRMLYNGIDRDDGIEPIRPAACTDLTSEARMAHKYKLHTRKESYSALRHHFPSTFASWEALDSEGLRLSASDAIEAINLFRAIGDDDSTTPHMLVALYLASGCTLPDGVLETLRGADVERCVLLREALLERSAWMAAQLFAGGASADCRGAEGVCDARIAETRAAVLYGDADEWMHADALGESMRSWIDGMELEKGRGICGICAGMLCERDRELRRELWEEMPALLARVEEEMRGARGGHDEDEEWEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZG9</accession>
    <name>A0A2G8RZG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZG9"/>
    <dbReference type="OrthoDB" id="3226552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="444" mass="49220" checksum="8A09A70F4D3D76CD" modified="2018-01-31" version="1">MHAAARPRPDPRMFLKDFDTPVDRRWSELVPPRTALTFAAIWDEDEGMVTFSGAHLLDSETAEKGCPNRMTNDSPCDVPFSDGESQVLTINDRFATALSGSSPNCPGYAPPPSAGADSLAFVRDAMDTETAMDSRSYLGFGGRRAPPGIHYTPDSPAIASSMALASLANIPFRRTLMNNHHPFDRTNRDSRSSCPALRGQNDEELRYCDAYDEDSSSDEVTDEGFFEDRRLTTGTLGSAPVLVEVNLSSAFSVTTTSTDRYVEVDHPSQAEAYSYEQRSQRTHYQRHSQQPLMKGKPSNASVISESAWSTLRDVERNICFNVPLEIGRRLKKTRSPRRSPSPTPPADPAEVLARQNYNHLPSPSYDDESELSTWSGTHGRQGCVPVPNVSIPRPLTPKGSLRRGKSLLNRVVLGNLRRGEGKDDQWVYVEVEHKVKQRMCAVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0L3</accession>
    <name>A0A2G8S0L3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10448</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0L3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0L3"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="561" mass="61487" checksum="F73B20E02A8D64BC" modified="2018-01-31" version="1">MLSFLGHRRTCAAKQKERDERIRSLPPEFHAPLSLDEERLLARPVSEIVAGVQGGTLAAPHVLLAYGKKALKAHAATNCLTEVFIARAWHEPDGWARTCNTQGPLAGMPVSFKDTVGVAGEDACIGYSAWVGKTVQKDAAIVRLLKDAGAVPFVKTNVPITLLSFESANDVFGTTTNPHSKAYSPGGSTGGEAALLAYGGSRIGIGTDVAGSVRAPAHFSGVYSVKASMHRFLRTGNVTSMPGQEGIPATYSPMARTLEDLETFWKAIFAMKPWEYDHSVLPIPWREVDLASGKPIRWGVLWDDGVIAPSPACRRALEIVVSELKSRGHEVVPIDAPSPYEGLKLGSQLIWAEGAKLCTRPIRWGETNDPGVQQAQIMFAMPRFLKGIYAWYLRHIRKDEVYAGLVECCTEKTTEEYLGLIAQREAYRDRWFQALRADAFDFILTVPNALPATPHGGMKDGFKGSGYTFLWNILDYTAGVLPVTHVDKEQDALGPGEFKPRNAVERDIYKMYDAQKMHGLPVGVQVVGKRLEEEKVLEGMKLIEGLLRDAGKAYTLLDPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0P1</accession>
    <name>A0A2G8S0P1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_10451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 7"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0P1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0P1"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000025">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="20"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL27304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="108" mass="11688" checksum="A58797B058AE20A7" modified="2018-01-31" version="1">MGVTVEVITPGDGKNFPRKGDKVTIHYVGTLLDGKKFDSSRDRGTPFETEIGVGKVIKGWDEGVPQLSVGTKAVLTATPDYAYGVRGFPPVIPPNSTLQFEVELLRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S176</accession>
    <name>A0A2G8S176_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_10674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S176"/>
    <dbReference type="STRING" id="1077348.A0A2G8S176"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="118"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="5">
        <location>
            <begin position="30"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL27523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="426" mass="47387" checksum="75104B44942ED4D0" modified="2018-01-31" version="1">MSDSATLSSVLESQAALVQEAALALPHQFTQCTYSLGPIRQAVYLCLTCTPATSPESPRGICAACSIACHTDHEQLELFPKRAFQCDCPTRALAHACTLHTAEEAPNDKNQYSRNFRAQFCRCGRAYDAEKERETMIQCVACEDWFHESCLNLRERPPSREPTPEPPVDDDDYDGLVCSDCVRKIDALRKIAGTPGALMVVRSSEGDSWRIIGVEETDSVLVDTETKDARVNGKSEEVLSTGVKREREGSVGAEPSTKRARVSPDAESAPCLAPPQGPRVKDLLCALDGSPNGDAIKKEEESLQPEKYLGAGDVFLTEGWRDRWCRCKNCLPSLEARPYLLEEEETYEPPEDPDSGLSLEELGMRALNRLPRERAINGIMAFNAMRDDLMQHLRPFAERGTEVTEADIRGFFDARIQELQSKRRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S194</accession>
    <name>A0A2G8S194_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S194"/>
    <dbReference type="STRING" id="1077348.A0A2G8S194"/>
    <dbReference type="OrthoDB" id="2753034at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013984842" description="Hydrophobin" evidence="6">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="10258" checksum="B7DA2E858855F7F2" modified="2018-01-31" version="1">MLTLSLVTLSIALLAAAAPQANNSPCSVGSVQCCQSTETAGSPTGTFLTALLGIVAPDATSVLGINCSPISAIGIGRSACSANAVCCEDNSVSTLISVGCVPMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1K7</accession>
    <name>A0A2G8S1K7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1K7"/>
    <dbReference type="OrthoDB" id="2686513at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="25159" checksum="5865350B4772395B" modified="2018-01-31" version="1">MKLNLQLGIAVAWESLFLFDCTIFSLTLFKTLRERRRNPVTSGRRDIVSLVMRDGALYFAVMASANLANTITFYVLEPLLRGCLSTAASSISITMMSRLMLNLHASAHGRSELATTRVPGAGSSTESTDNSTSLLFTSRISMPHALESAWDPEASRLNRESVYVRDLYAGDGRGRDGGYIEEVYELADYRGGADSDQGAFLRVPVPTHGGVVGEGGVEIAKPIVGGRVWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S231</accession>
    <name>A0A2G8S231_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S231"/>
    <dbReference type="OrthoDB" id="3350812at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="329" mass="36879" checksum="88B8197B7535614C" modified="2018-01-31" version="1">MTTNGPFLLPESFPSATSLYLYQVNRYISFASMTYSILEIVSTLPDEVELIWPARRGFMKTVFLINKYSPLIDFTLVALVDLVRREPEACRVSFQVLTYSYLLGTLVSEFILIARTYALWGCDRRLVYCALFIAGMMIPHAFYIVYDMLRESDFKSGQEVTHLIGCMPNIHDRNAWPAYTYLICSETMVVILTVLKRYVDPEIVQGSFASVVLPTMYRDGTCFWAVVLALSILNLLMMFFAPGGLSYSVQMPLRVVHSALCNRVLLNLRRAAACVPSEGSEDSSAVLTTVVFHQQPMTNLGTGGETLTNYTFVGADVWVDDPESDSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2P6</accession>
    <name>A0A2G8S2P6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S2P6"/>
    <dbReference type="OrthoDB" id="2794493at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1112"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1386" mass="152483" checksum="2D5D38B31D744C01" modified="2018-01-31" version="1">MEGNGPPSSSLSTPQTRSGSSTPGTPLSNETNVQTHPVDGAATTAEHSTTLPEVSFESRPSKRRLKEKLAHQIDNVKLARGDKCMLHPPHHELAHDYELSFQDPRMNYRKPATKPEPHFKFSGIPAVPSYNGFRAMVAYEQDLARQARIAPAHPQLLNFFKRLWCYYHQESELMSDELAQKAWLQLSDEERYRVIEMYSKEIAQAQVAANEAAFMAIPTSHIIAPHNATDAQAQARLAGPVAQQPPLPPPPPPPPPPPPPPPPPPPPPPPPPPPPPEFTPPGAVQHPDPFTPVIESHPFEPTVQQHPRPLPETHPSTSLGQRLSSTGGLFSHAPPWAQVTAGSSAPSASHAIYPDIQMFNSFSGASGDYDDNWSPHVTPRASQAPTSQVASQVPQASPRAESQLVDNQTFDGSGDPNGGGSLPFPDDHLDNDSTGSDYQSFPSWHKGKARAVDIIDQESNKSQHASGAMPPGSPPVHQPPQISAMSGDQSGNLTGAVVVLLLNELRAIRDGLKENSELQRLAWIPRFELKRPVGFLDGTEVASSPHPNSGAIRARKRKNCINERLSHWGGEVEDGSEKDAEVQESEHLNRVKARVRNLLQSMLGIDVWKHSGILFPSLTEEQIKEFDEGALKCTTQNFFIDFDQSWKLFKPNRVAREVFLNHYFARVAGGAYSKNPTPEHLLTREVIGGVLDNHMPYCRKRWRESIQPLSEDRLNAIKAQAAKNSRKRSIHFARSLVVRRCDNLRHIQLWLLLEPSNMDGDEPVGGETKKFPVQFNILRPRWASQELCNYWWSLDNEYRALYGKPVHQRATRGNPPRDRVLPKDSAEDGIAPLGLWRNCYDQAWLDSLELCLRRELEIIDEDFDFNFDSASALPICDPLHLVRKLSMDISCFPYTIHMMFSIPHYPMVSAEVPSMFVWDVPGVNPWTALRMDVLVIKMNNQEGASKVYVLAIERLSNKHHFIDLWENPLCRGVSPNALTSKGRDQGPERMRILFYTAEMAWSFHSQAEDVLRSYTANRQHDTSTHPANPPSVSAAAAAAVQSSTRAAIALSRPMDDGPGTLAAGEKRSVHSPSISAAATAAVQSSTRAAIALSRPMDDGPGTLAAGEKRSAHSPSVSAAAAMQSKTSRSAACGLKSLHNESPAVACCSTSSGGCSNEHTMSAVKDELHSIATKLDDFLDRVDPRRILTAVPSQLGHAAVSHAEPAAALTEEVSQNCPMMLDTTPPFLHAIQLVLSSLRSIIKMHNGSSGSQKNNLLVQDDGSPRELQARRTQHLKRRNPAAPSPHVSKRLRTSEHADRTTAITLFMLCAGGHDLTTVRFGIVEWVADAHQLRAQVYIVGMAAWESATALYATLRSVYRDEAEPGYACLVFPSHGLAAMFVEAWTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2R5</accession>
    <name>A0A2G8S2R5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000029">
        <property type="protein sequence ID" value="PIL28073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2R5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013661394" description="Transporter" evidence="2">
        <location>
            <begin position="22"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="9771" checksum="67487B1D5A60BD5A" modified="2018-01-31" version="1">MRIPTITLALVAAALSGSALARLAKSPKAAAGPAYLAGDSAGHAVAPDARADVEKRQLTIPDVVSTVTDALAAAEDSVDSAVAPLLPPPATGSDQDSGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S302</accession>
    <name>A0A2G8S302_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_09687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S302"/>
    <dbReference type="STRING" id="1077348.A0A2G8S302"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL28150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="116" mass="13460" checksum="7466A61E576B55D4" modified="2018-01-31" version="1">MPPFSSNPLNETGYSRLFRRYPGLFGVPFVLLIVGASYGMQQFTQTRYDLHSQKVTAMSKEQELGLQKNRKQFDIREEYFKLSSTAAEDWEPKRIQRPKGVPEWGVPPEEPPQKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3G1</accession>
    <name>A0A2G8S3G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3G1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3G1"/>
    <dbReference type="OrthoDB" id="3224221at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="776" mass="87863" checksum="168C188C37D7422B" modified="2018-01-31" version="1">MSLSASFAQTAMDFALDDVDVSSTSSDVYVTARSAFDPSSSEETDTPYATPRTQSIPPSHPTPSISRLHVPGSFQQSSGSLTPMSVGPTNDIENVLMSELHSGQRTPRACDEDDEMYERESSAEVRRHLDDDSKSVVYQRRNREPTPEDFGSDDLLMDSVENSVEVRRSDDGHDSHAVRPRRDQELTSGGLRREVNYWKEVSKYRQGQNKELKKQYADAVSRWQKMQQQNDATVGKMQEQMSKLMDFMNSSRTAAESELRNKVQAEEVRIAAQHQAIQVAQEQLNAKQAEQDKIAGDLREREAAIEKNRAEVENHQATVSRLLQQARTARPRSSAPPVTAQPLAAPPKPVAPTRATFFHSDTTHRPRSHKAGSSTRMFLTAIPESVDDADKGSGSEGEDDPPRSVPRAATSSRLMASAVGDDVEVHTLTVNQLVEAIRQSLRKEMAESSSRRHRRRSATPASESEPEVDRETRIELLRRVRELYKKQCGIETDKDWHGHQEADRPAVQAYNTRGEGAPSINNIRFDMRTSGSTVSPWNYVIFEHLLETFKANNATFISDNNITDYYINGLIEDKFSRGRQMWRGGQPKLKSTGVFETPEECETRVLLADERLKERARTDQRRRNKFECRHATVEKVIALHVGDTESDVAVWRFLEKVLDLLGPDGMSSEDTCDDLPETVFRVKVLEWRRPMDDHMAIIDNERVLDRDLFSRQGSQPGKRLRDGTLKSTRDPVRRLPQQLYNPDWLKAQNAQQIHTLAVSSEKFDWIRVVATLAHTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3I2</accession>
    <name>A0A2G8S3I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2757153at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="972"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1050"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1271"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1404"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1455"/>
            <end position="1470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1494" mass="166497" checksum="4016A94B9568E210" modified="2018-01-31" version="1">MGKNKRQLEPDREMGETDARPGEDVAQGNSKSHSGLETGVKIEQEKGESTITDSQDRERKLETAIQKAFIGFTVLDIVNTPFPDTQYEFGTWNGRPVVDRAVVGMVRSFREDGKMPEKATISIGIEKSWIDLTSTSKQDLSWSDIPRLGWTQAVEHAVVQFFGGRHRMKACIMWANVLEDERTKVKQKLERLKKSGGQSTSEDEALRLEEWLSRLDKAIQDAHLWVCRVYVLSELSNECQLHLSKNEVRPSRQATADEKMFMSRLELLNAMASWQQKNPLTSPPDHGTKTWREDIYNVAFSEADRRAPYMFMFTNPHAFKVLGSICSFSYLRNGKTITLNTLSRALRPISRASHSMPVPAAGFLWGWMIRRACEELALIASAVSFPKLGLDVDGDGRVLEHMRLLMKEDPLPEAVKDVQVVTDTRDLILRWTTRDNVRDVVWSGATLEAVDEEYIKHFRPGPALYHFGDDEAPEWVVALQEYKATIGDILKIMWTTKLQDATLITPSESGSPDAIALENAYDKLQWAWTMREVGGVAGCDMPLPTKSFLQDLLCRLEDCALGFEWLVRSVDGLCDSEIRLIDLPTFDYISHLVTLLSCERLFVPGDRKEDQICAWLSNRLPLLAEVSVLLGEITTDNMRAFYSLSQNRWREKIVRGHVAVGNIPEDFPLELRKIMPFFEWSMQDRERVAAAAQWIKQAWAADESAEREDALANRLCKSIAHLNPDALDRVPGLAMLYRTSRSWWTEVPRSIPEEAWMYAYQCVIGLKLWAETSGRILRHSSGRTLRDELGEYLSMWAQPRCQESHKSTSNGEWVFWDSLVFEGVMAYGSELGLPACEVQGRVGSSGNVNIAKLVTTRTFRASSQPSGSSISAFLFTPHQAFFDNADRIEFMELHPDTRLYVPPNTRTAQFSIDTLDFGPEDEDDPDVFRTMEEFCNEDPVRYAEFKKRAKRGANKASDFDSLRPQQYNLDESCSESEPSSDYEEPQSTRSLDRQHTQDSTPHSHADGSNTSTGDPLDSHHGNPSDAKDEDELAVRITNFQATRTPGDAHNSPTRQEPDSSSPQVRGSSARPEREVSSGPLCDTSRDEDQNGRCQARPATVTSEVEASSKVQLSLSSRSQHQASMEIEGEGSIKIASQGSIPLASRTTSPIERDPSGRTGSQMPTRLEHETSVTLESEIGGQPAQTTLGLIDGEGARKNEGDRSGKVDKDVGGEEADADVSNKTHSTTNATLGDLPPLVLAKPPLARARGRSGPLRIQPVRDPPCKNPTPPAASTTAGMHSSPDQQQDCSEDHDSAKRTASGPDQHSSSRSRDTDQTDSPVDAVSIPSSPGIPSPVADLWNSPDLQMQEISDDREGTSYLPMEDFATQDGEGDTDRVQSHRHGKNAAASTHAQAVAPAMRRRPNNSRAESLENQVNQQIKRRQQTADLSSSQPPPKKPKTQPAAFTSFQFHDDHTGNSGRGSQPSTSQPRNRNALAHSLKKSGFTKQELKSFEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5K1</accession>
    <name>A0A2G8S5K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5K1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5K1"/>
    <dbReference type="OrthoDB" id="3269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="287" mass="31110" checksum="BF84C1E620D84B14" modified="2018-01-31" version="1">MTHVIAMQGKTNKNKAWFRLLKRHVATRAPAFAISSPSFCLPRSRSSALPTSPPTQSPRPRICHPFLSPPQVKSMYKLIRRISSGIFPRPDRPWSEDATSTAPQIGRKRRLSTPEPDGEHEREHTPASKKFRAESEADATPAPATPVPATETETEEVKEVTEGVKEVELEEKPSAPEGMKEKDEEEASSETQEAAAVPLPDSPQLKATETEDADADGEADTDADAQGEVDAKATAEVPSATESKEKAEKPLAPTVVTDDEVPGLTLASKSPMKKMERMQAAVLTAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5Q2</accession>
    <name>A0A2G8S5Q2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S5Q2"/>
    <dbReference type="OrthoDB" id="2687259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013883349" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="920"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1249"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1321" mass="150034" checksum="298573319F56F3CC" modified="2018-01-31" version="1">MRWSWVFLVFLFSLVAMRAEQCYGCKKTYSNLPAHLDNKTKTCLREAFKQKKAEDARAKAAEAKQRLKARHAQLQLEREASMPVLIEPAAPNRRQRRVPGKFTDMLPTSLKGLPHLRLKPGVTAPIAHCSNVVIPPPSFVPLAASPRPHATVEDAPDDLMDDARPPSPPPPPAPIPQPPPAPIPIDTQPNRFGVFRRYTSCPRSDPEEGLTLDTFADAGTHLRAPPDSRERNPLRPFGSTAHKLLAEAGRVAANSFAPFLNWSAFKLMEWQYTGSVTKFLSELQHLVDTVVLDNRFKKEDLVDFSVDRAQAQLDNYQATGGAFSADDGWREGSVLLRLPKVGADHDDEDNTPGYLVKNIWHRSFVEVIKSAFRDPSARHFHWFPHRLFHKRATPEDPNAPPERLFTDVYNSDAMIRAHEEIQKLPRSPDDPPDVEYVVAGISVYSDSMRLASFGTASLWPIYAYVLNMSKYLRLKPAMFAAHHLAYIPSLPAGLFTTYRDTYNVPPSEVIIRFLKHELVHKIWLLLLDKEFMNAYEFGILILCGDGIWRQVFPRIFFYSADYPEKCLMAGLKTLARLACPDCAMDRCNFWRMGMKKDLMDRIKLARQDSSMFHRAISTVREWIFKKGVSPDGANVKRTKLGLFSMLPTRSAFSEQFAAFGQNVFKLFVPDQMHEFELGVWKGTFTHLVRILIAAGRDACQKLDERFSMIPTFGRATIRRFSGNVSRMKQLAARDFEQILKCAIPCFENLLPEPFNSIILDLLFELGRWHALAKLQLHSDSTITALHVATSTLGQAVRAFCHHVCPKYATRELPRETQSRQRHRAAAAQASGRHKAAATATSAAPKFKAYTVPDTPKYHRLGDYARVISEMGTHDNLSTQTGEFEHRRAKRYYGRTNKTLMFGLQIGLEVRRAAVLNKISQSQPLAPSARKQRRSRRKEKSRASRGRQLQLRFEDSQPLPPTQPEQHYYISSDPRYPVRLDDFLYENDGDAACKNFERDLKDHLFRRLPGGEALPADYMPTDDDLFRVRIEGDRLFQHKVLRVNFTRYDMCRDQDSINPRTHPDIMMLAPDGVAHPYLYARVIGIFHVKAYLVGDDLDGTDDTEPEVVHVLWVRWFDIDPRAPGGFKVRRLPRLKWAALDDDAFGFLSPDQVLRAAHLMPAFAHGESDAALPGYSVARREENEDLDWNYHYVGIFVDRDMFMRYYGGAVGHQHGKPKEPQPPPVTPEQITPLSGHSYDDESEEDLDEETKEDHVDLPEEPEHPPGVDADDSESETSESESEVDSDGSQELNSDDDEALGPEDGEAEMDEDEYELAHAGFASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6I5</accession>
    <name>A0A2G8S6I5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6I5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013842835" description="Transporter" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="5241" checksum="543821F7A9301ECC" modified="2018-01-31" version="1">MREPEHTFFVSLALSLSIAAALPDPGHHSAAGVAQERQTPGDGVLGFLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6M4</accession>
    <name>A0A2G8S6M4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 7">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_09447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6M4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6M4"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL29395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="477" mass="52823" checksum="3BD2D1B11BE3A19B" modified="2018-01-31" version="1">MSTLPLGHKLSPEEETSFLSSARLTSPRFPLPPSATLMASSFLLLLASFFAGPTLFSTHPPQTQALDNRVGKLPALGYNTWNAYGCNINETIVLEAAHFLVKLGLKDVGYNRVNLDDCYAEKSRSSSGDILANAVRFPSGMNNLTDEIHSLGLDAGIYSDSGWFTCQLYPGSYQNEYRDAKLFQDWGFDYLKFDNCAIPYDDIIRQGIVGKYQRIADAIAQLAEDTRKPPLILSLCEWGEEQPWLWARRFGQSWRTTGDISPNWDSVTDIINQNSFIAWASDFYGHNDMDILEVGNGNLTFEEAKTHFTVWALMKSPLLISADLATISDENLSILKNEQILAINQDSVVGTSVSPFRWGINPDWVSNSTHPAQYWSGESQNGTLFMLINTLDEPADMFFNLTESPWIRAGRQYSVHDLWAHTDNGTAVRNFTAQGVPAHGVVALLLKDAGDEPVNAGPPCARPHWCISQNGTLGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7F4</accession>
    <name>A0A2G8S7F4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7F4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7F4"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="235"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="398" mass="43327" checksum="65C718C4E36DB6E0" modified="2018-01-31" version="1">MGSIDALHAPMTSYDDPVELILLGTGTSSTLPHVDCLTAPPGAKPCRTCLSTLTPEGRKNKRRNTSAVLRVRGRDGQPKTIVIDVGKSFLPAAVEWFPKYGLRHIDAVLITHAHADAMNGLDDLRGWTLHGAIQPHVDIYLSEETFEAVKVAFPYLVRKEFASGGGDVPEFRWHPYVTDRQPFEIGDTGITVKPFAVPHGVCGAKPVQRVASIPDQIAAVAPFSTSSPCASGCPGTPTATGATTPTEKEDFMCLGFTIQDAVTYVSDCSKIPDDILADLQASPIPVLVLDCLRLNPHLSHLSMEQAVGYARQLKARKTYLLGFSHEVSHEEYETMLRAVGGRRVPPKELTEVVKAGLDTLDLAGEKVWVRPAFDGLQVFVSEKGQARDNEYFDYSNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7L8</accession>
    <name>A0A2G8S7L8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7L8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7L8"/>
    <dbReference type="OrthoDB" id="47488at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04486">
        <property type="entry name" value="YhcR_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013593966" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="324"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="636" mass="68836" checksum="745CC21D9A77EEAA" modified="2018-01-31" version="1">MKHLSAVKALAFLASGALAVKISEIQGIAFQSPLAGQFVHGLTGVVTAKDKYGIWIQDQRTDDPRASNGIRVYGANVKSANVGDLISLSGRVAEYRRSVADLFLTEIDYVTELTTISRGHTVVPLVLGEDRTPPSKQLSALDVGRDGWLSVPSNLTLLEVVNATLRPDEFGLDFWESLEGQLVTVKSPTAAQFPDRFGSVWVYGNWPTTGRNERGGRTIHFNGPNEAPPAHPEAIFIGRPLDGTRNPKAVMGAVLSDITGVVTYQFGAYYVLPLTAPDVVKFPDFTVPPSTVNSTSHPCQIRIGDYNVENMNPRSYHIPKIAAHIAHHLHTPDLVFVQEIQDDSGPRNDGTVSADRTLRALANAIKRASGGVEYAFVNVEPEDNKDGGQPGGNIRVAYLYRPDKVSLLPGTIGDATASTVPVIDSEGNLELSFNPGRIDPEHSAWEEARKPLAAAWQTASGVRFYTVNVHFSSKRFSSPPQGNARPPVNGGWEKRTSQANVTARFVSSILDLAADASVVVAGDMNEFTAARSVLRPLAALLHDANDVAGVPAAERYTYAYDQHAQEIDQVFVSDAVARRRGDVEHVHVNTWAKTVGERASDHDPTVVRLWVCDAEADAVSPGEEYGNDHGQTAFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Y4</accession>
    <name>A0A2G8S7Y4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_08095</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Y4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7Y4"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11370">
        <property type="entry name" value="RNase_PH_RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="22"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL29886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="264" mass="29191" checksum="C6A9AA50ED5CBF82" modified="2018-01-31" version="1">MSSRIEILNDGGFRSDGRKQYELRDVLIDLSQQGTADGSAQISHGLTQVLVTVFGPREAKMRSHTLHDRAVLNVEMSVAPFSTGERRKRSKADRRILEMASMIASTFEPVVQTTLYPRSQIDIYVHVLQQDGSLLPACINATTLALITAGVPLHDFVCAVTGGVHSTSPLLDLTTVEENDIPHMTVAVMPRTQKVTLVTMETRLHVERFRELFELACEAGQTIHKEMKLAVKDRTVVLVGAMDAGLKGVAVDDRDRDVVMEDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8M7</accession>
    <name>A0A2G8S8M7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8M7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8M7"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="277" mass="30567" checksum="A5A0DD45D299C2BF" modified="2018-01-31" version="1">MPRRRRLVIITLPPSIPSGASAIYVVVGSRSKPTPRCVLWRVYGDFELTSAQNTRYVVVSGARQKDEEWDPEENGGFAVHETDPNQGPVDPLAALEKSTDAQNHMNNIQVPRIEALQNLADHYGSDPYSHSLRARKRFRERKKLDKAREDADEALKSNYGLPEALALSKEDDESRSKAKTEWEQGRQAFEERETSKRRKLGAEVVSVMPRIPSAHISGRNGQSSRHAGGSSTGAPNTSDPVSSLRAKILGNTARQGSLGRLKPPDAKSARGLVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8R4</accession>
    <name>A0A2G8S8R4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07695</name>
        <name evidence="5" type="ORF">GSI_07741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8R4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8R4"/>
    <dbReference type="OrthoDB" id="2798901at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="417"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="561" mass="61677" checksum="E5656B1671513B3E" modified="2018-01-31" version="1">MQVPIEVYEAVIDEASDTPASLRLLSLTCSAFLPRSRYHLFSCIIIRSVQQMESSSLLLDSCPWLPPLIRKVTLSAPVPEVNSIPNLRLLDVVPVRLLSRLPNLRALEMEMRAYEYDVEKGPWLSFHRSALWRYQKYGGRIQNLELIGAFPKLNEQGLFTFTPDRADSQDPYGHEARVNCLVASRDSKSIVTGSEDGTIIVWDAEQGTPIHEWFAAVPAGPIRSLALSPDGQRLVSVAAVYKGGGPPVVWEIGRGTGGVQKVATLEPEAGTGLACCAWSFDGALIAWVSGDGMVLVWDAQTFQPCGGPLNNSPSHAATWPYCLQFSPDSRYLGWVAKQSPAKCCLSQPLTDEPLASYFVDPDPIRQVSVPINAFSFDPDSRRIVTAHGDRGLDGPLEEHRVRIWDIATGTLLVVVGVPADTWIVNNISFSPDGLSVLSASVNGSVRIWDAESGKQKALLFEMSDYNVSPREYRCPLQTARFSSDGRYVAIASGISRPGRRFQDRGIVSLWRTSDASCVAEFIDHKAAWVLDAVFTPNGEFLASADKYGIVHIRPLARLIEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9D2</accession>
    <name>A0A2G8S9D2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07547</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9D2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="132" mass="14106" checksum="16DBB2713FDAEE1C" modified="2018-01-31" version="1">MADCLAAFPITLFRCLGPWNSSSSIWPAATAGRDGPCNPAALPNSDPQALALSTAFSTLGIWTITVLDLHDDVFRLCTGSSLCPLVTPDTPSIIARTADSHAPAGEMRIQPFSFAPSVHTPERCLRDLKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAA3</accession>
    <name>A0A2G8SAA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_07400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAA3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAA3"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="244" mass="27986" checksum="F261A844960FF9FB" modified="2018-01-31" version="1">MQEPASVLFSVLNFLAHWVGVRKVQARVPDAHPMKKYYIMFALASMNAWVWSSVFHTRDLPITEKLDYFSAALAILYGLYYAVVRLFHIYPTERYRLTAGSPSSSRTGIYVAWTLVCSLAFLGHVSYLSLLPRFDYTYNMIFNLAVGMAHNLLWVLYSLPSSLTLIRRYPGLPPNYRPRHAYKPAMFALLTTAATGLELFDFPPWAGTIDAHSLWHLATAPIAVFWYDFLVEDARHEGWRPVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAT8</accession>
    <name>A0A2G8SAT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAT8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAT8"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="533"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="554"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="590"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="626"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="677"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="713"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="749"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="785"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="821"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1016" mass="110337" checksum="C8A045A5ED2F7065" modified="2018-01-31" version="1">MNTTLDASTSPTESRQNPGDRIQSPPAFLDLADSAARLGANVPDVSARMLKRMEHERQRALQRKMFEDQMRALEQQQARELLTIPLEAPQHLAVSAPTTPPRVNAVLSDDHSPTYPSSLARSIMDPDALSQAVGKADKRKSVTYAPSVNHSPELPSSNQSFARPGGAKSMPASRRTSASEHDEDLASHLQGLSLAGERADRERERGVTPSGMIPQSILRSNSGRFANDYAGVGVYNAGMMLDEQLDQEMHNAMRHLPTSDEDKFSNGFTNKSTSSFTPPFPFISMLAFISRGQQKSSEWPQFNGSGRIPENLSRSDRRNVTNPAMSLSPGLGDLSGPKANGTVSGTTTPLLQQVSQGLAQGLSSRRGSPLSLGDTRSSIPSARSVPATPLPGMPNSAGSLAKAPGTPLSGDPHNINGILSAQISRQLSEESELNPSLSRMPSGQFDGSPLSFNSIQSGIDEQYGGDGVYGLSGGIDGGRFNTYGFEAAGRGAAAVGSTGSTALYHHNGAKYGFNMNGRPNGGADGKMNGLHGPKHKRGDIDREFNRFAGTRLEDLVGEIPQLCKDQHGCRYLQKKLEEGLPEHRDMIFRETFGHFADLMTDPFGNYLCQKLLEYSTDEQRNVICESVAQDLVNISLNMHGTRAVQKMIDFLSTRRQASVTPVNMISLSSWIHSIILALSLHVVVLIKDLNGNHVIQKCLNKLAPEDNQFIYNAVAANCVEVATHRHGCCVLQRCIDHASEHQRVQLVNEITYNALTLVQDPYGNYVVQYILDLNDNRFSDAVIRQFTGNVCALSVQKFSSNVIEKCIRVAEHTTRKMLIGELLNRTRLEKLLRDSYGNYCVQTALDYAEPGQRALLVEGIRPVLPLIRNTPYGKRIQNKLQREHNDTYGGGGGYHHNQQALVNMALGNQGMGMAHGHNAGRHMSHLQAGALADAYTAQNSLYALQGGPGLHAAPLHASLQTHSIDSYVMQGSNNHSPGLTPPQSHAGAFSGMSSYGNGFPVAVTDPYQRQSFAYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAY5</accession>
    <name>A0A2G8SAY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAY5"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047150">
        <property type="entry name" value="SGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45831:SF2">
        <property type="entry name" value="LD24721P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="8"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="552" mass="62185" checksum="F74CCAEE627430E4" modified="2018-01-31" version="1">MATALQQAEQLKTEGNALFAKNDFTGAYKKYTEAIKLDKKNAILYCNRAACAFGLNRFIDSSTDATTATKLDPSYAKAWSRLAQAQMSLDRPDQAVRAWKRAVAALPVENLTPAQKKQRDSYTAELAVVQAKVADLEANPRKPNDMVTTNRLEQLPWSRAAALIPGLQATQQWNSSAWVISKAYLEWQDAIEKMKQGRIVRNPAGAPAGSQGYFGHLGVLAGISNALLSDNRVFHITDQNFIDMYNKQVMFEMTQARAWGDSGARKVIEQIPARLRIGGWDAVRPAISTTVRAWIMRGFMEDKFKNNIETALEFYTSALEVLQWGKELWKDVSFDDKGAVFRETFMRGVECMRLEALIGAYYKHPGENSKFPLREILAGADALLAELEGTPEDPSLSSTEDIAFYLSFFQYPRAQAHATRGFYLHRMAINKRKREGLTQELVADHMLTSAEYLKAANAYPPDDEKHAWYIHIAFTVQNEVGGPASYLLMILNKLHDAIPRMKPIWEFSADAKSGLHAVLRATMKMREQLLRLAEGKTDDELEHMVMRCERVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB18</accession>
    <name>A0A2G8SB18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB18"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB18"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="289" mass="32838" checksum="291E4EEB1C6A30FB" modified="2018-01-31" version="1">MAAFLEPKDDPKKHLTLSGHATPRTAARPGTALHDFVDDGRPVIAIDMDDVLSQTNEAVAEWHNSAYGTKMTIADFYYYYYWMNPYWGNPDDTIRKVEEFWKTDYIDLALQVQGAHDALVKLAQNGFRLVIVTARQVRELDRSLVWVEKNLPGLIDTFICTGQSQETLLDGKELVTKLSKADVCRKIGAKFLIDDSMENALKCVVDADPPVPVLLFGDYPWNSRVGRYSDVSKETSFEEKLKREGGREFWKEDSVALEKEISPSAPLTRVKGWPEVLEWIEKKMVAGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB56</accession>
    <name>A0A2G8SB56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB56"/>
    <dbReference type="OrthoDB" id="3352450at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="10557" checksum="7D8C4F34DE8A8C81" modified="2018-01-31" version="1">MAVDNSQALSVQAVAQATRQARRDGTFAGLSSGLVSAILGSKVFRLNRNATILCGVATGVISGYQFTQGFLATNIARLDAEKARLDNLAAEQDHNVSTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB80</accession>
    <name>A0A2G8SB80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB80"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="19289" checksum="547660E80ECC76DC" modified="2018-01-31" version="1">MFGDRIPRIVPHSPGSTEPPRDIGEWQPARVILAEITKEIYGLVVCPVLECGLAAHPVRPSCEMLIPETGSTFVLDEDEKRVGWAADSRTVFYLKFDDMLEFWEFGSTVAHLRSDEEIRKADLLYKLSLVRLFVPSHGPGGLMDAICTNVDHAPADGDQSPSSSSSESSSITISGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBE3</accession>
    <name>A0A2G8SBE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBE3"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="11324" checksum="307EE96C45218106" modified="2018-01-31" version="1">MGTYSGAGALRTSLDTANTRAACFVASCSSTIFYKNIVGIVLAIATAELLNDCIYEPESQPFFTLSMLIGGSLSYMGWAIGNDHIMPWPWIGAVACLPFVLFFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBF1</accession>
    <name>A0A2G8SBF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxC5 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBF1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBF1"/>
    <dbReference type="OrthoDB" id="2800707at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="1">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="50769" checksum="648564C8EB11D994" modified="2018-01-31" version="1">MYRPNYSVSNADSPSSVREYYPGVPKFLEVTQHSYVEEELIKLFRHQMAFSHASGDGCAKIYNLSLRTFQEGSTKITSEIVWNAFFIHALLLHHTRSRLCMKLPHHGEQSDRIASALLACNEAMVGVGQVEWAHACDDCEKIVEVDAPEGVGRTWARLTADCSRPGTGIATLTRHSIRTPVHREVEEERRRKGRAMFELKRRLQARDVASTIRAVPSVDESSSLLDDPDLDDPAFLDDPGLTSNVERKKPTVPPAKVKSTLTRRWTHNEQLLVRPCGIVISRATFYEAESLPNCRLFLNASFPKHFPDARPSFLFFDNNCKLLAHLVNVEDKHLLHMGFPVDVFHAVRKHGQSDGYCQDHCNPAGFPELIGEQPGEWVFNSSACKQVNVWFAKFFPIVREMSEVHFNFFLDEMIAIHNQVQISELTSKHRHPRLVPVEEFVWTQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCB1</accession>
    <name>A0A2G8SCB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 14">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_06095</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 14"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SCB1"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13 14" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="784"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="17">
        <location>
            <begin position="1151"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="237"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="567"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="675"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="13">
        <location>
            <begin position="1155"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="13">
        <location>
            <begin position="1182"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="13">
        <location>
            <begin position="1302"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="1184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL31394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1457" mass="160045" checksum="D217AB1771443BF5" modified="2018-01-31" version="1">MESSFEGGAAAAVDERHPLILLISAAFWVFLWLLSWVKALMAFVTISLPKFIYSVLSYSMTLTLNFWSFALLFCACAVALNYWIRFRYLNKYAHLKEPPLVKADAQELHPDVNTPEQPPSFHNYLDEFLQAVRVFGFLEKPVFHELARHLQTRRLLAGDTLSLDQDRSFYCVIDGNVQVYAQTGQPMQLGRSGTWDEEDMNGYQLLNQVGSGGTVSSLFTILSLFTENVKMSWQDGDVPDEVSGYQGRSSTSASPLRTRTRRSDSDVSQFELSSIQGHRSRAASVSSSSSTVHAANLTTPRRGRSVSGDTRQSRTPNGVAPSSTYLSTSSSTETQSHYGVVARAAEDSTLAVIPAEAFQRLTKKFPKAAAHIVQVILTRFSRVTFNAAHNYLGLTTEVLRTEKAINDIACHPLPQSFYQGGLKQLRHRFDSVSITSDSEAASDYVSFPSSGRSSKSSVFLDLKKMKSSNGSAGSKTSSTFSPTPITVKANGSHHFVQAGDLLTSTGSLTETPKNMSRSASSSGTIATPTPPPQPLELPTLKLPTDEFDLREEVMSCIAKSIGLLQPPLSGGDSTEASPAFPPSEGGASPRSGQQAFRSSFGSLSLLDIGDDASSSRTESSSSIHTDGYMSNLDNEVEILFFPAGSILAKAGERNTGLFYVIDGFLDMILPAENNENESAKTERGKNVQPEDEKTRSQSRFDFLFDGNSRHDDTTKRKRNKDRSQKPLFTVKPGGIAGYLSSLTQTASYVDIVAKTDTYVGFLPSPALERLLERRPIVLLTLAKRLISLLSPLVLHIDGSLDWVQVDAGQVLWRPEDISDSFYIVINGRLRAITEKENGAITITAEYGQGDTVGELDVITSSPRRNTVHAIRDTELIRMPQTLFNAISARNPRTTAQLLRMIASRVRTELDTSHKNMAAERSRGNINLKNVAILPVSRTIPIEPFARKLHAALEGVGTPTAFLNQASVSDHLGRHAFTRMGKLKAAGWLAEQEQKFRIVLYIADSAVSSSWTQTCIRQADCVMVVGAGDDPSIGEYERLLLSLKTTARKELVLLHPDRSVVAGSTREWLKLRPWVHQHIHVELPGANPSVARSPPAPQDPAAVVALKKMKDRVQSEIQRYRGARIDPRPQRPQHMSDFARLARRICGKSIGVVLGGGGARGISHLGVLRALEEFGIPVDHIGGTSIGALIGGLYAREGDIISSSGRAKQFSARMGNIWRMLSDVTYPIVAYTTGHEFNRSIYKAFYDLHIEDMWLPFFCNSTNLNPSQMEIHETGYAWRFIRASMTLVGLLPPICDNGNMLVDGGYIDNLPVSAMLTMGASAVIASDVGSIDDNSPRNFGDSVSGVWLFINRWNPFSTARNVPAITELQQRLAYVSSVKTLEEAKTTKGCLYMQMPVQEYGTLQFGKFEEIQKKGYHATMDFLAKFDAEGLLPSAYVGDTHKPAASRTRGRSARRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCR9</accession>
    <name>A0A2G8SCR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCR9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCR9"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="8">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="159" mass="17399" checksum="2485DD2F60BF5AE8" modified="2018-01-31" version="1">MSSQNASVLVVCLGNICRSPMGEAVLKHVAKERGLDVTVDSAGTSGYHIGEDPDDRTVAVCKKHNVPIKHAGRQVQQSDFKRFTHILASDESNLRNLERVKPHDATAEIRLWGSYLDNKPIPDPYYGGASGFDKVYDQCVRLSNAFLDEVLGASTQGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD02</accession>
    <name>A0A2G8SD02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD02"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD02"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="881" mass="94371" checksum="B3FDD07B7A197F17" modified="2018-01-31" version="1">MTTIPAPTIVLSKEEWADADFDLPDDDHIHASDAESDKEEEDWDMEMNLGKTGGAKAQLVLQGMTARSGPSKIASQMFTIRPPLPQAHSTDDDDDDEGVSTIKVTALPKPVAAKPPQSPIDEDFEDGFALPSDLTTLSLRPLSLAHRTSKSSLEWGDRDQTSSSQSSDAYSNFGFADNSPSSNYTSASLPETETEEDEDEEDILEGLDVPSGLFESGSGAKKLGKILELKKKTAFVDDRVKIASPDPEDDFEIGLEIGNDTELSPSRLLQTAQSAVRSTTASRSKSAPPRPPAALRPPSRLKGERAKSPSNPPVSSMSQLRRITAPPASPPSSRTAQPFRAQTYSQAVASPSSMTFLAVKPGSLRVQKSHSGLKPPSPPATRKLGRKASLPSMSESNQPQASGSGSGSAALGPSPGARYDTPTASSRAKVHTATTGRFHGLEYNVPPTRPSTPSSNPAALRLTMPTSSSRLKSRTPISNVFPGPASAPLARSTSPLPPPRPPSRPPSAASSATSAASIRSTHTQSASLPNAPKVLKKPKRTRTYGDGTELDLFDDLPTDREKEGKYRVQPKGYGNRVPGASYPKPSEASAMGTIRRKSTRNFSGGSDSSKAPASSKSLKRTARIEFPSKTSEPSKPERSKDAEVKKKKVVSPSLTRRKPTLIRNLGGAGAAKVVGEMKWNPTTLRWEGNDSALKDFDAAMVSTRPALITHLTGSSIGSPVGSFASGARVVGNMIFDPQRMCWISTLPPDEDEPDVFADLADDEGDDDWEQKGGTIRASQQLSGSQGSIAPSDKSSNSSASRIEPPSPARSHTRSMSESESDRCSRASMVCDVDDTFVEKCRLAEERHRAELKNWLSVGHDVFADPDRSYLYEIRALATRQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEM8</accession>
    <name>A0A2G8SEM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEM8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEM8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="270" mass="30561" checksum="F3C6E103F16A38A8" modified="2018-01-31" version="1">MHRIGRQLLQERKAEIMQMYGEEGAGAIEKKDLQGRDLLTLLIKANMATDIPNSQRLTDEEVLAQVPTFLVAGHETTSTVTTWCLYASCKYPEIQQRLREGLLAIQTLTPTMEELNALPRIAMYDNVLPLSAPLTDVHGNVLSELQILKGQRIFIPILALHTSKRIWGEDAAEFRPERWQNPPKSISSIPGVWGNMLTFLGGTHSCIGYRFALVEMKAIIFMLVRTFEFELAVPAEDIVPIGRFLQRPALRHNKGEGTQLPLLIRRHRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEV9</accession>
    <name>A0A2G8SEV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEV9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEV9"/>
    <dbReference type="OrthoDB" id="2794820at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="201"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="295" mass="32288" checksum="026DCD6B4DF22620" modified="2018-01-31" version="1">MASTANGTDAASSALDELLALPNGLTMDNTYGAALIGTLYGVLLHQMYNYLRLHSGDNIYLKSYVMVIFLLDTAHSVLITALCYLKLVTNYLNLSYLVTVDWPLSLLTAVTAANVVACQSFFAYRVYQIDRKCRMVVWFCMTCQCAGFGLAIAFTVKALPCGQSFQNILQVAVVSSRTRCRKLTWSWFLQSWISIVLGIATFVDTVLAAVLVLVLHRSRTGIKATNSLLDTLIAYTVTTGVLTDLFNILGFIFALATSQYLYYAAANMLGTKVYTNSVMAAYAVFVPSHSLASPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFW5</accession>
    <name>A0A2G8SFW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-trimethyl-L-lysine(9) demethylase</fullName>
            <ecNumber evidence="2">1.14.11.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_05356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = N(6)-methyl-L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60200"/>
            <dbReference type="Rhea" id="RHEA-COMP:15538"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.66"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.66" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFW5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFW5"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="8">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="377"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="661"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="805"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="970"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1195"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="811"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="971"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1211"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL32652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1232" mass="135152" checksum="8150EEE235DD1664" modified="2018-01-31" version="1">MATNSRGPSVAHLRAATPDTPLQPDHFYGNESIQLPPSPNSDGRDWLDPADDPTAQRGIPVFRPTLEEFQDFEGYMNRVEPWGMRSGIVKIIPPKEWTEQLPSVVPQLDKVKLKSPIEQHMLGQEGRYQQQNIEKRKALSLREWAELCATEDLRAPGVNEIGLYARANNGSARRTRRGRKAANINGSANGNADARMSETAEPEQIKREQDDDTIPLHPHPSSSALISPPHSNRNLSPTDHDEAAVEALVELESASGSSKSSGRRHPLAQEEEEDGEDESTKQHKDEEVEDAKDVKPRRGRRAPQTRETKEAELAVRAEKDRDFLDSFEPHKAWLPPGTEPSSYTHDFCKDLERRYWRNCGFGKPPWYGADMQGSLFTDETTAWNVACLPSALTRLLPASSKGLPGVNTPYLYFGMWRATFAWHVEDMDLFSINYIHFGAPKFWYAMPQARANALEQTMKGLFPGAGKNCDQFLRHKSYLASPTLLAKTSCRPNYLVQQSGEFVITFPRGYHAGFNLGFNCAESVNFALESWIDIGRRAKACGCVNFSVRIDVDQLLRDRAAENRQVYRKPGKSHLIKDEPTDDLEPGPSTKAKEAKSKTSRKRKPDSEPSVTKAKKQKTKSSSASPEPVASSSKVTLASPAKQIKRVMLKMGPPPPPKEQEFPCCLCPSDDKQGLLRVHDPPAWWYDAATTDAKLGPCMAHEECAAVVPETWVDEIQPEGEMGTLGESALRLEKVVFGVDAVSKDRWNLKCTACTKLKNRAHGAKIQCVSPRCLKAFHVSCARDGHANGVVYRVLREVEKEVILVDNQPPRRQPTPPPPPPAPGILILHPDHQPRPPTPAGPSGVAAGDHPMDVDPVHTSSAPTEDPPEPRVLKSIRKTEVELLCHQHNPATLAKKKEANEKRIRDRVVNIPEGSLIKLRITNGIFEVQLLRIVEERRTVEVLWDADKDLKKEFSWKSVLVGNTEGIVAQKPSDVAPKPSPAPAVSRPTVIVPSAPYPTSAYRSLASASSPATSATHAAPPPTTSSPAQAPPPMYASYYQQPRTATYSYGSWTYPYSASPPTYASASGQPSSSSYAAPPYPQHHYNHYPYANTATQPPYPHYPQYTGYNGYAPPPPPNAQSLPQLSAQQDARQKALLWQTPYTGPKEPVPKPPPLTVPVVPSNPNGYGPVVTPVTSAAGSQGPVENGSVVEQVSSAVPQASQTAPVEAHESSAPVTTTDAPAAPAVAASMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFY6</accession>
    <name>A0A2G8SFY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_05380</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with PEX6; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFY6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFY6"/>
    <dbReference type="OrthoDB" id="2187at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000105">
        <property type="entry name" value="PeRoXisome assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="439"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="727"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="970"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1004"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1023"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL32676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1062" mass="115019" checksum="B28E07882F83AFF2" modified="2018-01-31" version="1">MPRHCRIHFASLHSSLVNLPISLYGPLVERAVRPQGLAVHLTLVSTTRNPSSSKDAKQKPDAYVGWTGMASASSLAHFNPGDAAERGLETVEMDPQYADGLGFALGDVVEIGLLHDLPYATSVGTEPATSDDWEILELHASHVESTLLSQVRVAVVGQEIDVWVLGRTRVRLNVVSLQPSTTKALLLTTSTEVSIAPKLRSKHKTMAAGSELKGSGKTSVAPNGITPAAEKTKVPRQARTLRMLPQRLLGDTPLPSHSSDDDGIAYVSYKTLSSLYPRGVLSELHGWRATVRRVSPPSNPDKDATPASPAIQPSARILVPSGEGSSLKGPQPVTEVKKNEMVVVWSPDVPVPDGHVVLNPVVDNAEDWDLIRLIFVKHDADYPMPAFERASVPVAKQLHTPTSHGLAGVEEMFAKCTQFCLTAFAHHAFNQRIKGQPAVVPGLLVTGRSGAGKTALLHAVSKAMQHDPRTLTHTLYVDLSRFNGSPVAKVRTHMKYWMDKASWHKPSILVLDNIDKLMGTELEHADSFHTRHITELFLGLYGSSSRATAPNASGVVLLAAAESQASLHPLLNSSHLFQEVLNLKPPSKDARKEVLAHLVKEHMNASDITQDPTAPLNYTALATQTEGYSVTDLKDLVARAVHRTAIRSSELQLSGHDESEQTTLTPADFSAAQVDFVPHSLRDVKLQKSEIAWMDVGGLRETKQVLRETLEWPTKYGPIFAQSPLRLRSGLLLYGYPGCGKTLLASAVAKECGLNFISIKGPEILNKYIGASEKSVRNLFERASAAKPCVLFFDEFDSIAPKRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDSALLRPGRLDKSLLCDMPDKQEREEILAALGRKITFAPSVDLAELANATDGFSGADLQALVYNAHLEVVHDTIAHPADSSKSKPNGIADGDAEPIRYAALGREDHGSVLSRAEESVFQRRLQRIMAGTSVDGGRGQSSPSPPSATSVPDGGKGKGKQKPKHEIREEHLERVLKVTRPSVPREERERLQRIYSAFVSDRSGDLPVPPEAGGVGKRVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHK8</accession>
    <name>A0A2G8SHK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHK8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="18217" checksum="CA68C72D2320F6B4" modified="2018-01-31" version="1">MLVIIAIITVVFLILLLSSNIALVFLFREMSKLGRLELVPPILRRVVVNNYRDDDEDDDEDDIVDNDDNRTPRVPPPTPLLEVVDLPFEFMHAHKPLPYRMIDIYYFYDMAEHWTATYWSMYDVLNDSEDDYALLTPLTDGLDLDTVVPMSYDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHM0</accession>
    <name>A0A2G8SHM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHM0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHM0"/>
    <dbReference type="OrthoDB" id="2757531at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="912" mass="102061" checksum="F9080A90598302B0" modified="2018-01-31" version="1">MSSPSGQPVPATPPPAPTIPAQPTTPSSQRRDAPLPPIPTQEPASPSEIGGPATDKQGSAESESAPAGATSVGTSTATSSSAPASTESTTPVGTPPTAPSVPVPAAPSPSKPVAGKKHLVRRRDDFVNAKSKKIALGSSAQPLQLKNTPKKKHGGLIGPVVEKRVAGANEFLYRTWGARRSGSDLEQVAHGQGTSERPTRRLRSPRSPSAPVPPGYPKSPQVAHQQPAVPQQQLMHQQIMPQHALLQQQAMAHQQFFQQQMPQQPPQMYQPYMQVPAPMAYGVPMQTPNQVLGYHGFPHAAPPLNPGPSLWNDYREAHQDDDADQLYSTPRRVRTHHVHYDLDDDDDEGSNYNNGRGEDGNDEGENDEEENRMEYEHQYGQEYDLEDEDLEHCEDEEEPNEEEQLMEEIVQDDEMEDIDEHAPKINQLGEQTPPPDPQQSERPRPVPQNSHEETSGTSDHIRQQSLSQGPNDDRVRTSGRKGKERATGSSTAGPSTTGSSTLRGGRVLPSQGGESYFLLLLQQFSEFNEHQRKESRLNRQWQQNMMQYVKKLDHKIAHGSAAATHGTSGRSSVSRVKVNRDRPSNSMASRIVLEPRDQPMSPEDLKRLEEKEKGHLADLQNVVRVHFKKLLGVPSYKEMAKKNPPLNNNKVFEYEASGPQYFTADNFRVDFVKPWKEFPFNLSAHDFFASHLVRVLKGGGYKKAAVPARYHTYDHVAEALDVHMDHARRRYREAVSPPDTDEIEKEKRKARMVSRRGTLYTSRFRVTKHVEKYKRFEDIFVNLRGAHMSADETDRDENDKKKYPVTFSIIRAAWMSFAFRRLCRELDKEHIKNRGVLIGDQGSGGSGPRVREDTTPAQEADTRAPVGLWRDCYDSAWLAGLKNDQIRRLNIIDEDFGLALPQSDDEEEDEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIA8</accession>
    <name>A0A2G8SIA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIA8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="127" mass="14217" checksum="BEF25BE5EF55DF5A" modified="2018-01-31" version="1">MVAGSGVVKDGAVDTGEDMGLHRRCNASDDTDNVSPSASACRLTVKCIEADLVCPAYNTSSRYLGPRRHPQLYDRGLQPVERGSHSSTVLLRLYQNNDFLHEMPLISDAANRLLEQLFRRIYLRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SID1</accession>
    <name>A0A2G8SID1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SID1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SID1"/>
    <dbReference type="OrthoDB" id="2749506at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27653" checksum="9FFF651A9765B211" modified="2018-01-31" version="1">MVLPSERTSMQGRNHNAFPCYSRDCDFFFNLSPLYLRAENTLFCVPRHYFQISDVFDGMFALPGVPNTPQEGSTEACPLFLESIKADELKDFLRVLFVTADPEDASSVPQIPTSWVSVLKLASLWQFTSVRKKALEHLKSEDCLSRFEISRHYGVPDWFLPALKDLIYRSEPLTADEILRLTRLAGLGFAVKMLAFREKALIRRYFTPRASGLGTSRRVVVRLPPQNCRISDEEIGRAFEVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIE0</accession>
    <name>A0A2G8SIE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_04143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIE0"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL33520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="501" mass="56373" checksum="369B9E8A7684C271" modified="2018-01-31" version="1">MEDTQTLLYTLVAAFAVAYIIRWRTNPLNSIPTVGGPSAPILSYLSAINFLFHGRELLTEGYQKFHNSAFKVALIDQWLVVVCGPLLDEYRKRSDDELSFIEGVEDVIRTRYTLGPEWLNDPYHVDIIKEKLMRTLPVVLPDVIDELTYAVPDYIPATEDDWVSMPVMKTMLNVVARVSNRVFVGLPVCRNQKFLDIAIAFTIDVVKDRTIINVFPDSLKSYVAWLTTNVRASIRHAIPHIKPLLDERKAKILENGVGENWPGKPNDMLEWILEQAIPRNSSDESIASRILLVNFAAIHTSSNSITHALFDLAAAPQYLQPLREEIEPIIAAEGWTKAAMGKMWKVDSFLRESQRFNGIGLTSVTRKAMKEVTLSNGTVIPKGALVVAASYPTHHDDAIYENANTFDPFRFSRMREVEGEGMKHQFVNTSPEYISFGHGRHACPGRFFAANELKAILAYIVVNYDLKIAGDGERPPNMYIAANVVPSPKGEILFRKRKVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIH5</accession>
    <name>A0A2G8SIH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIH5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIH5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="912"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="770"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1023" mass="112867" checksum="2C24F9892747749A" modified="2018-01-31" version="1">MGLWEKNDKSLSFPPATISSYYPAPPVQSSFEPRTTGNKNKSIFSKEDGFSTNLPKAPRDDPNASTSSRSMTMKASAVMTPMSLTPIDDNPGAQGLAGKPKLSPFPEPSLNLALPLNATYLRIQSLSGSRKIFQSSRRDHLRTTGMTMISAELEDLQLLCKRYAHDIAAPNVHADTSAKVTSPGATLSFPVVLGKRLRTYKALRNELPESLWLLKGPEATSPGTQEHPGRCTFADALTERTVAAVWAGARAARTVLTVQRLLWLAAWSFLSLAGGHPAVFSPPAAYLRANVVSPLDCFLVLSTAPGTPLPVHCASIPDVSEFVELAPTWDFRQECSGTVALALNVTLGDAIVWWRVWVLWSRNRPMFALVCALLATLSFGIADASYTCGGTLASFQVLGPRYGSTTVTAVGSLFTNSGFGFVTICFSLFSNTVLTCMVGYKAWKHRWDTWVLGTTWVEGLLVLLVESGVAYCVLWIFILGSQIVWIASPTTLGATSWSTGIVYFTEGCLIAFVSPECQKADWPNHKKTCGKLNTPIYDITVWHNTSITLSITMSNGLTSFVPVLTGPNYLQWAPKMQAFLQTTGRWMQPMTKTCPTLVATPSNQDKVDTWNEDDTAARGSIRLRVDDSIGTAIDSKTTAKQVWDYLKDTYGKPGIPVVYQDFRAAMGISILSDSNPIPAMDKLRAHFQTLETNQFTVAEHIKGMILLSKLPSAMDPIIQVYTSGLTATQTTPAVQLVTFDEHQGCHQQKPRDSANKISAVKRKPQDPTFRQQQQRPQGQQQQQQRPYGQQHQQQRPQGQQQQGHRGRRGGCGHSQQHQGAHQHTHIAHVADTFPVITKGEMDTLPQSRDPRALLHKPVRAETGANHQYPALRRAFTLAKELGVEPTTERIRKLEMLVMAGNRSKDPVLMPMTELHSTRSSPESSATYSEDSRTTSLNVSRSPMPFAGSSVRIVEVDSGEDTDGEEHAAKRRRRTLKERIRPHLRERIGAVIEDEDMEETVSLGLSSEDEQDNDIEEFFDRQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIS2</accession>
    <name>A0A2G8SIS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIS2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIS2"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="474" mass="53608" checksum="EB3C80D8A62333C3" modified="2018-01-31" version="1">MSHTTPATYLVWSLMATLLGAFLVFHLWKFDRFKCLKLGNGPYTGAFKRLMTVRTSWISPVTVQVVDDVPSPQYTYLLSVPGIIAYAVGFAVIKYKEGFMSLPIYGIIPTPWQFWTPSHKASILPLYLLFTISWSLEMVTHLEELCFWLFLVNSGSVQQDWFRSLYFRTWIVGSIVAVTYMPLVTIFTREDPLKCEAYTFLAGSLGSLSLTLWFMPILWTFPGFIENLKRNGVDTRTVVRLMTFHELNCIRVVFRFIFVVPLLVLAVDGVRPHQHVNESPFWTEFLTSFSGIGCAVSSAITLVIFFPRNVEGEVQSRHATREKSRGSRAAREEYSRFSELDSYMAPTSSAPKRPSIASPTSRDREYPPTLSEDRPYTPMKSLPLGEQSETRSQSPGTTFTPNRRVGAGVVLQGRIVDATPALVPAQLTERALAAHDESMSGVHPFLHNFTSPIDIMNAPPKKWYVKRQHAPLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJJ9</accession>
    <name>A0A2G8SJJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJJ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJJ9"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="57"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="637" mass="72034" checksum="D84BAF487D3361E1" modified="2018-01-31" version="1">MSQRPDKPLPLIPQSSIVITSSTSAQYEEQGEAMAKEDVVLPFADVLSRSVTPDPTRREYALLELLRSERTYVSDLVLLRDYQIPLASGRLSSMSNIWQGVDATIRQYLGVGPPVSDTDVGPVIPPGSSSGRPRPSTIASNVSAMSFGSIFTLRPMKTKDVNIVFSNIEELAAFSEEFLHQLESALGELIEGNEGEDFVGRLFLDFLPKMESLYETYVMNQPHALAHYHRLSKTFQFDVYFPRSQILAHKSSNAWDLPSLLIKPIQHLLHYPQLLAAILAQTPGTHHDKAALFEAHARMTEMTRGLNEKVVREVLAGTGLVDSSPAGDDALRTRKKSGLKVGLPGFVDLGRIGVPWAGAPNKAKDPVLPEVNPVAQAIKAGGERLRKYEEFMVAFTMQTMEWADDMRNLVASFDELVQRFARASSRFDIHAPHMALRKQLSKELPRYLTLLDMGMAACIRNFARIQSKFYANVRDRWRELWDSIRVDEETNEGVTETLRTWERRFSEADEQLHRLSILRDPQEEPTSSRHEKEENYSKPTVESFSHYFFLRPSRHTENQFLTSDTSTKYSHQDEDAARLPALYKCRVVRPYQPPDGATYQDIPFFTLKEGQVYEILAESACCCHGLQSENLISSLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJV0</accession>
    <name>A0A2G8SJV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_03758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJV0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJV0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL34049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="554" mass="62626" checksum="6CC4746F8DD5AA59" modified="2018-01-31" version="1">MISILESTSLSTTTYVSGAFVALGLLLLALRRVFDRRGVEHISGPPSPSFLFGHDYAYACQEEACSLEFQWMREYGATWRTRGAFGRDVLMTVDPKAIQHIMQKSSYNYTKKMTFVHSAWLLSGPGIVTVLGKVHQRHRKIMNPAFSAAHLRTFLPLFQRIASKLSDKWKGELVATGELNALLNRWLSRATLDVIGEAAFNYDYNALDGAGRSPIAKGYEDIFKDVDYLPNKATVLFRATWDYIPAPVLKLIRYIPIHPWTRLRNLNDLFRQYGWRIIREQGPNMDTEKKSTTKDIMSILIKANSSEDPKSRLDDEEIIAEMFTLTLAGHETTSNTLSFLLYELSRHQEYQARMRTEIRGVRARITARGGNEFTIEDLESLTLTMNAIKETLRFHSIVVGMPRVPEKDDVIPLAHPISSTTGEVITEIPVRAGQVIHVSFAGYHRLPDVWGEDADVWNPDRFFRIETGKQTNVGVFSNFVSTAAGVRACIGWRFSLIEMQAFVTELVENFQFDPPAEKVEIQRAFAGFVFGMFPVVKGQADRGGAMPIRISLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK12</accession>
    <name>A0A2G8SK12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK12"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK12"/>
    <dbReference type="OrthoDB" id="2536450at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34862:SF1">
        <property type="entry name" value="SPARK DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013916728" description="Transporter" evidence="1">
        <location>
            <begin position="25"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="27230" checksum="CE083DE190C2B58F" modified="2018-01-31" version="1">MVGFTKFALLATAVAGLQLAGTSAQTISSQCQSSLASLLTSSDATCLNAQALLGLATTTNNASVVPTLNTWLTGLCAKPACSNQTLSAVVSNLTSGCSTELSSLGLGSIDASELTALVETAYPTVRKVACLADTKQNNELCVTEFLTAVQGTTGNLSIANIEALGTNLVGGSSSLNLPSNVTCTDCVKAAYSIINTVFAGLVPSSVPSYFQSTCGSSFTDGSSPSDVTESASAASSSTTVTHNGVLPALRLSPAVGIAASLLVTVSSALVVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKR0</accession>
    <name>A0A2G8SKR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKR0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="661" mass="72261" checksum="CE5E2EA8C929E83C" modified="2018-01-31" version="1">MRLQRELNAALERRAEIEDEVVVCRRVQEQLENEVRRCKEHLATQVQNVSRLEEKLAAQLDLHRETSSSQLVKYCALEKRFEGAKRDHDSTREVLKDLQTEFDSCKRRAENQDAETGATIKALSSEVVFLRDENVALQSEVSHYRERSETLGSQLEDVTTDLDVTRTKCINLEFTLEERLRDVWTDQGRVHACAAGDDSNLLALYDEIGSSFLLKTGSSDTAADERHASTQAEANETNETRPSTQDDGYKKAAGRHPAPADGQDETRLSAQEADGPTDPTANDHDPAPADGQDETRLSAQEAADRHPASDTTNAPAAHGQDETQVADAPTDPTDDTNDHDPADGQDETRLSAQEADGPTDPTANDHETAPGDSQDETRLSAQEAADRHPVPTGPPTADANDHETAPAHGQDETRLLAQESAYSGPMSWYEPSVSFGLRAFLVITLLSCVIMGLAGSGTPCIFPFPGFSLVVSSSSNSLRVNTHGREITQVSATLTTGWNICDSEAGYEVKWSAAPLLGLPGVGRYMHLRFDNPLVYWDFKWRFADACFQTCRKTSELKEKIGRISNFEVFSRYARTYLGERNDQVEQSSEVHVNNHAEGGVEVNGGDTMRGADAKGDGDRMDAMGEDGVNTKERDNGAEGYALSMMGGDGVIAVEGQSGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL32</accession>
    <name>A0A2G8SL32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL32"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="503" mass="57266" checksum="AD82904B67EE8EA8" modified="2018-01-31" version="1">MVPERVDERLDLLADDDDDDDDEEDDEPPPRRKLQDPRAQFLEATKQQPIIQCPLDLDLLDGPVQGGCGMDGAFCVDYALRVRMCERCYKENVVEGTDVLQSLPKQYRERVAQVVLMLIPSAHPFEVADTNGYFHRINPLSHLMQDFYLKSDLEAVLRLFWPLPEPEDVMDLKSSYAFLIYAWDNVHATFQDHTKWLMAYTVIKVLFQESAPIWQLCGPDGAGFAHDPSLSEHLHSNALQPEAEEDPLPPPEVKSHDQLVAEMTAFERRARAAYDRRIAGRYAQMADWYAHILDEHFCGGRWDHDALPNAFDGARLWESLVLDDHARTLLDVDTVMGEQQLEDVVEELQAYPKMVMKCLAAAVRTADGSDIGEDGKELGSRGCDEYPFAWPEINIHWQEKHPEESVWEGSPGKVYRAAVWEGGIPAAEKILAVLVEQGLCERAMNRKHLHTLIKDGRVFCACGDPRMPETRYQGFDWAALVKHVSDSNHLNENACRTVKFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLS1</accession>
    <name>A0A2G8SLS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PIPK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SLS1"/>
    <dbReference type="OrthoDB" id="158357at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="1271"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="129"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="750"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="805"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1063"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1112"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1212"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="847"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1028"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1115"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1213"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1240"/>
            <end position="1253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1621" mass="178714" checksum="E28C9CFDA073DA5F" modified="2018-01-31" version="1">MTLPLRHLLAVALFVPFLLAPAAVFVAARYALDILHDQLNSTTGDDEMEKPLPDLPTAASRRRTPSNLTLTVDARAHLHRFLLHTLGEESELREKDNWAERLGTALNDLGAGVENGGWLAGLRRARYVRKRHHDEEEKRRAEEDGRKDKEEEERARNRTAKGRSKLKEVVVEDEPVDDGPSGELLAASLEQLREAALRPVVPSAKPSMKHLFLSVSGPPSEPVEDMGFKLIRTTTLHCSFNPGEFALPKSASGEDVREPVVLYGLHEWDASLLSSDDPFQVVGGTFVFRGVTAHPQYHALCRVLRLAVFAYLSLLLEQDLLSNSDVELHYPKVTIPNLPTFPPTVERSSSSADVKEKQLRRRDSGSGLWSFLSKKTEDLLHRATHVSPLGRRGSVDLAFGQKVSRATSLPQGPDGGFLSRRLSMLSGSAAPRAPQESENEAQAATFAAVVKRMDAWKDLLSTSPNVAFPPPSFVLSIADKETQDPTRRPLGDEKAALSSLLGWQGKEPPGKGVVGVSGFVRHQGITVMYSEHVPGASVLSNPPALSKSDTASIESQIPMRTPCWGHRRKWINYRYYRCGRHWDESLGEAIIRWCEAGEDHCGHPDCQFNRGEHDMRWIHGGLRLLATVSVPTSSDASTSDDSVRMWVSCAVCEKESPKRIMHDGTYLISFAKFLELLVYSPAIHALSPPLCEHTTFPEKPWAPADTPIPHARFDIIRHFSHKGRVVTMTLADVREVFEVHVPRLQILRRKAGEKKPVPDPTPIQHPTAQGSSVLGESHKVLRREIMRWWQGLSDRMDQLEEKFVSDHPSSFHKSLPRLPSADDAYEPEDEEQLSTPKVHPKEPPSTPQTLTASLPEESNGTASRSSLSSEEDRTPRPSQFRAGSASTTDSVLTSSTDLSSSSTTADGADSLQLLAGLRFKFQQYEQELYSELAHTSEKNLNDVRRSFVTAARGATKRLAAWEKKHASGAQGRPGAQADVLEVPEPEWWKSGCHAVPGGNIIVREDDWGSIIAFTLSTADYQRELSNMSTTRSAPTPAAAPAPTEAATSSRPSIFRAPESFRRFVSGSTPHQPDPDLDDTGWQEPETYSAVISRKEHPREPAALAAIRDVLRQKPSADSGTSSSLLTAAGITSGRTSGTETPRSARAKPAVEVSTLAADGLVSGMPVTVESAGKILHELEAVSKANASRSSLSESRRLSSGFFEATIRRGKASSLMTDGDGSTIQDGAGSSINVTPPPLPPKDDGELKEGEEPPKGPGSVGSDAEQPPPTPAKSGFTSSFTNSLTSAMRYVFKPEELPRPPSGMSHHGLLLSADAPAIDERPHIKYDWTIGKRLRFSCTVYYAKQFDQLRRRCGVDDVFMRSMARSENWAAEGGKSRSNFWKTADNRFIIKTLVNAWNVADLQVLIDLGPSYFRYMEATASKATVLAKLLGFYTVEIRNLETGNTQAKADLLVMENLFFDRNITKTFDLKGIQGRKIKDRSGSHSKTLFDGEWIEGQQRALTLVRTHSKVVLQEAIKADCEFLARSNIMDYSLLLGVDEENKEMICGLVDTIGSYTFAKTLEYKAKQGLNSSKEVTVVPPHEYQERFVGAMDDYFLACPDKWTRPLDNTPVPEDYRDLPSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLS3</accession>
    <name>A0A2G8SLS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLS3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLS3"/>
    <dbReference type="OrthoDB" id="428342at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="230" mass="26102" checksum="4D0593D9A2DF2A01" modified="2018-01-31" version="1">MRDGLSDADDERDFSVASKWDPVRDTFRLEIALASTKPAIQGPLPDQHFSRAVVPQAVQAARTLEARRGDALRTFDWKSFMEPVLCYRELLYRSLCWLDVRARAHAALQPDRGRVHEPEFTVLHAVESPDSEARAFLLDRELPFELDVLHAKLKYWTCDHMAYLDALAALLARCTGRGKARARKDGPTDSEAIWTERGARVCLFIASQLPIGVQNDWTCLALKLKTEQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM47</accession>
    <name>A0A2G8SM47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_02606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM47"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM47"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013890076" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="458"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL34819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1058" mass="114611" checksum="497A0070A8398DBC" modified="2018-01-31" version="1">MHLGYDAVLFVIMILSRHTFVQGYSPEYGAGVAENIDIRSQSGELQDEHDSSAAMLLHAVNGQSVTLAADPPRKSNGLTDVVQWDNYTLFLHDQRMFVYSGEFHTFRLPVPDLWLDIFQKMVAAGLNAVSIYIHWGLTNPAPGVFDFEDWRALQPIFDAAKLAGIFVILRPGPYINAETTAGGLALWATSLVEGDVRVNTTSWNAAYQPYAAHIIESVKPNQVTEGGPILLVQIDNEYSQTPEINAEYFADLEEQYRSNGVVVPFDSVIDFDAGRTYNDPGERLNFINGTGAPDIYGLDDYPNHFNCTNGSMWNPIQTNYHTYHTVNDPTRPFYMPEFQGGSHDYWGGPGYDACRARIGPDFEDVFYKNNWAANVRMHSVYMFYGGTNWGGINYPGAYTSYDYSAAIKETRVLWAKYDEMKRQALFLRSSPQFRKTDWIGDTQAGPAAIPGVTITSLSLPHTNTSTTDGADSGSETFATYLRNPDTGTGFLVARHANASALGTVRFRVRLPSNSNSNSNGGGTLDLPRTFDAIALDGRQSKLVMTDYAFGRTGRVLYTTAAVFFAGTVGARDVLFLTGDAGQAHEAALVLTGTGGRRASSAYVSYIDTPEATTVTVRAGFAGGLVTVWDSDEQLVLFADPVTAATFWAPAIRSPTAGTVPGLESYWQFGTNATVLVGGPYLVRNATVSGGTLALRGDLNASVPLTIVAPPEVRAVTWNGERVEVEGDGRGVLRGKLTLSEVVRGVEVPTLGGWRYADSLPEVKAGFDDSDWVVADHTSTNITQGMLFGDGRVLYGCDYGFCENNILWRGHFDATGAETAANLSINGGTGMDSSVWVIVLLDADGTAPLVAFAASVWINDVFIDSVTANTAAGDANALFPFPNGSVIAGQDNVVTVLQDHMGNDEGTNQKSDRGIRGFELVGGVGKFSTWKVQGKLGGYENFPDRVRGGLNEGGLYGERLGWHLPSFPISDSDWTPRALSDGLPNGKAGVGFFVTTFALDVPKGVDAAMSFQFNLEQGLAAYRALLFVNGWKFGKRAADYGPQTRFPVPPGILDYNGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMV1</accession>
    <name>A0A2G8SMV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMV1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="179" mass="18635" checksum="9B2C876DD0F17EB5" modified="2018-01-31" version="1">MAPFPSGVPNKELDDTAISPKLGITMAGCVLAFLAITAGFLFVARKKRRAPRSSASSASEPSASVQPKNPGPQPHRCTHHHEPVRRGISLPTAASSGRCLVCASQPAAAGRHGFEVPRSSHDSTRSLPPYTRHAAPTAVLAIGPEAPRVAQAITAPTTPPSPPPAYMARGPTASFRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN39</accession>
    <name>A0A2G8SN39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02972</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN39"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN39"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="204"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL35182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="854" mass="93729" checksum="E6DE37DA518B04D0" modified="2018-01-31" version="1">MALSYFPASASANVGSPQIVAESSPKHLNEGVQEAYIEHKDRLLKALDSTKSILGELRKFNKDDWVVRYPQLQEQPAAAESSISPKRKGARRSLSFPDDPSFQADVIVSPAKAGLTRSVTLASIADKDEEPAPDAEDDTDGLVSAAEASDFHVFRLDLKLGPHGSSSSPAALVAQLEKSSIANLLDDRVVSAVNHLDKLRSRIEDTSSKVLVTGDLNAGKSTFVNALLRREIMPVDQQPCTTAFCEVHDATENDGKEEVHILKDGATYSTKDETTFTRASLSDLDAIVSENENESQVLRVYLADPRDPQASLLSNGIVDISLIDAPGLNRDNTHTTRVFARQEEIDVVVFVVSAENHFTLSAKEFLTNASKEKAYLFIVVNKYEQIRDKAKCRRLVLEQIKQLSPRTYEDAEDLVHFVDSQQALHENTTPFGNLESALRSFVLVKRSKSKLAPASTYLTKLLSDVDLLVGANAIVAQSELERARDDINRVRPVLEKMKGSREALEESLEFVEEDGASRSLTRGKDILNDAVERVGQGQPGVGAVSLPVYPGLFGIWEYASEVRRALLASLDSAVKLTEDEARLITTEAVGRIAALGDKHLPDGVERSRRVFMPEAMFACRKDKKGNRRSRQPTVVAGGLYGLGLGLAQRPDMLDTSFFDLFDVQHQFWLHFGDGKNELHAEEVTVSTLGVVSVGIGALTMVGGKVVGARSLLEGVVRVWDLLENETARKWAAPVLGAVSIGLVGYYVLELPTTIPRTVGRRIKTSLAKEGEEKGEESSFVGAHAARVSRETRKVLRLAAWDVKERFRSAMDERGREVHGAEDKERGAVKALDYFHRVEQRTGEVRESVVLVSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN89</accession>
    <name>A0A2G8SN89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN89"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="83" mass="10102" checksum="1F7752618A3F3557" modified="2018-01-31" version="1">MVQLVHRPAYYYHWTQHRNLVVRVTFTQDPNHNKQLLATIKQKYGFCRLYWMRHLHFHTLVFDANDEVEEAPHFKKQSQLGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP21</accession>
    <name>A0A2G8SP21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP21"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="77" mass="8651" checksum="04DF69D637EA87AC" modified="2018-01-31" version="1">MSDHEAMNNVVFKFDVSLDAFGLIHKATISITLNGSETDAILRVREFLVEHWEAWAKSRLRDEFLAFLSEAAAGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP61</accession>
    <name>A0A2G8SP61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP61"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="75" mass="8300" checksum="CDBB4BA6F6C0F034" modified="2018-01-31" version="1">MTLEKESPAFQEPELDEAKEQGCQIPESERVRADGRDNEATPKYPGREQRRVGGQNVSFAQMVGMYGKAVGAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPV7</accession>
    <name>A0A2G8SPV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPV7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="287" mass="30009" checksum="38D405427792379C" modified="2018-01-31" version="1">MVLLGVCGIDRRDNLVEVGGEQDPICERVVLSRDMSYGEPGSGRQEEGGVDKREDTGVVMLPALESFGGESHGVTGEVDSGDENGSCSWTGWVTFGGSVEMTTSGLRAGSLITSRFESSLDVSCRRGSSRDEGGVGSVDPGFRAVPEVGFLPFSFFCIVFEGGETGESGGLPVFRFFVGLGCPSLSASFSECVCSFLFFPFFCGDVMSGCILVSSPSPSCSRSSANLAFSAAASSLFRFRSLAASFACSSFSSSSCTILANDCASPRIHTSNTPSHSLVGTGKSKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRR9</accession>
    <name>A0A2G8SRR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRR9"/>
    <dbReference type="OrthoDB" id="2339190at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013647922" evidence="2">
        <location>
            <begin position="30"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="27770" checksum="C2F45EE903463FB4" modified="2018-01-31" version="1">MFTKTTFVKYALAPLAAAAALSTLTSVSASPAPTALQARGDTYAPSSTSYWPQKTGDYGHDDCDCDFGWDKDHLPKITQPNKDTVWKVGTQQKVTWEVKWDDKKNGGDDGKGWQDGKYRRDGQDGKDWDDGKKCEQWGGDEGKDGKREGCKARLFLRKGDELPFLILAEGFDVKSGSADVTVPNVFFGSDYRVTLSIRDDKPELQSNSEKFKIVKDGEDGKDYDNFCKDGKDKDGKDCKDWNDGKNPGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS22</accession>
    <name>A0A2G8SS22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS22"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS22"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF42">
        <property type="entry name" value="ZINC FINGER, CCHC-TYPE, RETROTRANSPOSON GAG DOMAIN, ASPARTIC PEPTIDASE DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="293" mass="32311" checksum="2F125DEBF9129ABF" modified="2018-01-31" version="1">MPSLTMSNAGTTPTPLQLPAGYDISKLVTQLAPREYDGKTAQDGLHFISATSIYHLNITTFLPSFPETILWITLLNKLMEGAAEWAGPHIVMLAGSTQLWADFVAFETAFKAYFYAADDKEAAIAELIKLCKVQHKIGTMQDYTVKFNAIAAYTSFSAEDKCEWYHTGLPYKIKDILATSGHDTLSITKIQAVALTMDQNLLVCEEERPKQFSGGWRKKGEKAAATGKKPFTGNCFNCGKPGHHSFECKLPKKEQQAASSSGETTDLAALRAELKEIKEWLNAASVNEKREGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSL6</accession>
    <name>A0A2G8SSL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSL6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSL6"/>
    <dbReference type="OrthoDB" id="2755889at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="954" mass="105567" checksum="82D032B8CFFCB5D9" modified="2018-01-31" version="1">MFSPFEDRVVRDQCKVVFDAKERGKFVSSWDKTIEQRAGNWQIKREKERQSTYRPQLDFVAATCQYTVFLWDQIQNTKGEKGARQKLDPRIPYFDGKFYPPTYTSQKIRNVSRDVAPNIACLKPVTVLHPAYIEELNFCPRCNATGDDLKWKGWTTSGPRDVHGVSSEEQVIGVQMRCKRCKAERGKADTPDDEEDDAYCWGTASSQFWERKEHWEIPLGVPHMKWRSAVTSELYDLIVEFRPDTTSAGLAEHIKRKSTDLSRSELGLTQTQELHLLQYHKRRREYLLNFEARTKQQVWPGGGQDVKLRKFPEPRTGRHKEGYDNTSISDELITDIYLSWVRATRQGESEESLRTKTGTSKLGSTLTVEWGLTAPSALIRVPGVALSIDATFRTASKATVVDRGKTHTRVYKGGITSVVNEQSIILAWRFCFTQGNWELVELLKGVKRRLELLGVSEPEMVISDCCCHVAKAIHDVFPDAVVCLDVWHFLMRYLVCLVGGSKCPVRQAVAIDIVDAILKSRALPNSPAIYWSKEEQVARLEAAFEKWEAKGVWTAAAAKTHEEQLTHVRKGCLARPRDDVRADGSRIEGTHKGWNSLQRSFSSGLEMMAALGHDHVLRHNTRVESALKEPPKFIRSTFGSHHVHLVNDCARRWNKQLARKSRIDSDMEPLPVLEAPSSGETFGMIKMSSETAAHQSLTSIKKESVDDEELLDLSSQDLLDANYILSGVGVDPSLLYQLPPKPSGPIASVSTPTPHPCPLPHGAAGGDASLMSPPSPPPPPPLSQSAVHGAFAPGPAASSFQEPLAPQSSSAGPMDLDTDPLYDPESREQKAGIIEAASKTSDDGESVSSTQKRGDRKGKAVDRSACQSTSNRKRHAETSANTADDVIEISDDEGTQSQSKPPPRKKLRLYVPGMPAAAKANSAAATSSTSSAGTPSINPSSVRACCSPFAPTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSR1</accession>
    <name>A0A2G8SSR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSR1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSR1"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="469" mass="49967" checksum="D8A400256E08565E" modified="2018-01-31" version="1">MAATPAPNPRASLLAGLRTGGVRSSSGSIPNVPHTAAPAGTFNIPRIVAPKQEDNLFPPEEEDELSSMMSQNLYIHNNRARQAPVTAAVDGIPNRFQHQQQQAMHMNGMAFNPLHAMNQNQLQQVQLQLMQMEFARMQALQAQQYQAEILAAQAQAAQQRQRQAQQGNRRAASYAVPSTAGPTNTSFDLRSATMNAQMRRANQADQLRSRLGVSEDQVPMTAALNGKFGSRIGSGKYDSDDDDFSSVGARPPASANYTTVISGGTSLGAPTTPSVPSKSDTAVSWRRAPGSNSVLSANRAVSSPTVKVTPPPSERVSPPPVLATSKARPTPLRFTAEASNPVVSAVAIDTDGTEADDSSTSSKSNSTPSTPHSAGSVDVPPLSPREEASKKLYEGLGIGRPAPGINVVVSQDSQIVVQRLVSAPVRQPRGPPSNNEELVPKNFATRSRRKAVDALLVHARERQIIVEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSU4</accession>
    <name>A0A2G8SSU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_00492</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SSU4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF415">
        <property type="entry name" value="FI20190P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="943"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1024"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1105"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="287"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="643"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1308"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL36802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1570" mass="173527" checksum="DFD2E03AFCF64A85" modified="2018-01-31" version="1">MQLCSGAHWTDLSDPCIRSFLATSVPTAFVGAVLVAALPPVQARLRNIGQPLLDFLSLPEAEALLVSEGYDSPKDQHHINSVSRILLVAISLVEFLVWLGLGCYRLISDFDNAYSGIQCAVLSNTWLYATLRPIIWPTVTVPFDLFFLFILHLGFSVINGAGFLFDCYLYNTPFPPLLEIFIYAADLLAISGLLTIVFNVSLAVPDEHTKKDIGPEDYTTLWGWMTFDWVAPLIHKARDNHGLNADDIWLPSPIMRARPLYFKFSRLPGRLLVRLWKANSRDMLVDFLLMYVSVVLGYASPFFLKRILDALDVTQGDQRAEARALAFVYAFAVYACSILRAQTDLQHLFFGRRAGSRVRSELMVAVYDKALKRKEFSGVVGKGEDDTQPSSADNGKILNLMSSDVTLVSNTVSAMHIVYGAPFEIVIATLFLYKLLGWAAFAGFIVIIITLPLNDIMAKRTNRIAKGTSAARDKRMDVLNELITAVKFIKFFAWEDRWVKRVLDSRTVELQWMVKERLNTIGFSLLGTISPVLVSVVSFYVYIAQGNQLTIGTAFTAIALYGMVRLPFNTANTFLFQLLRSMVALDRIAAYLEEEEVDEQVSTLKGQCATPNDRETGLGIVDGSFQWNASSLRIDRTTPNSVATTDDASSSTPTQHGHFKLEHINVRFPESKLTVIAGPTASGKTALLMALLGELTTLHGCILIPKDPSNVDDHGLSHTISYAAQMPWLRHQSIKDNILFDFPCDEERYHAVVEACALNPDLAILEDGDATEIGIRGVSLSGGQKARVALARAVYAPTKYVLLDDPLSAVDSHTAQFLIENLFRGPLLANRTVILVTHHLDLVLPAAHYLVRMLDGCIDTQDTVENLRTRGILGKIAALEEGQARTQMGERNVVRADDSLVSGEAGGHGATNKKPRVLVEAERRATGRVKWPIYNIYLRASSYWTWYILLLLIIASQLMGTAEKFWIKVWGEAYGKEDLAPFLNASASQYWNGQKTQHVLIMAEPTSSGPTNVSTLPSAQAQPYFYLAIYATIALSSGLISICAAAVQYTGALRASKSLFELLLKNVVHATMRWYDVTPQGRIINRFSKDINTIDSSLSQTLQEIIQYATALAVAMFTIVAIFPSFFIPAAVVVSLYVRTAIMSQPAGRDIRRLESTSTSPIFAALGETLDGIITIRAFGMEARFLDGFFEKVDAAAQLYHMFWQVNRWLLLNLQMTSAIAILATTLFALSGYLDAGLAGICITSALSFTNSVYWVCRNWASLELDFNSIERVVEYLEVPQEPPTIVDCNRPPAYWPSSTSTNKDSFLVIEDLSVKYAPDLPSVLHGISFSLKARERVGLLGRTGSGKSTLAMSILRFVEPASGTLVIDGINIGHIGLHDLRSRITFIPQDATLFSGTLRENLDPFSPSGTTSERATVIETRGLRADLDTIVLGMQVSVGGTNFSQGQRQLVSMARALLRRSTIVVFDEATSSIDFETDAKIQATIREEFGGSLLLTVAHRIRTVIDYDRLLVLDKGKLVEFDTPLNLIRKEGGVFREMCLKSGMMEELGEAAAASLRVESDVREYPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSV1</accession>
    <name>A0A2G8SSV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSV1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSV1"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="489" mass="52445" checksum="B707318C672CEEF7" modified="2018-01-31" version="1">MDSAVSTVIQPHFAEPEQYELSSTSMEQPESGQQTPASGQLTPFSTPFSAASSQAALRAALDDGLNVQELAPVDRGVRAWMFCMSSFTLEMMIWGLCFSYGIFQNYYTAHPPFNTASSISIAAVGTIAIALQYTEALLISCAFGRYPDYMGYAMWFGLALYFFSIFGSSFATQVWHLIMLQGVLFGISGGLLYVPVIKLLPEWFSERRGLAGGIIFAGGGVGGFLFPFALTALLDKVGLRWTLRIWAIITTIFCGIALLGLRPRLPVPKYTHGSRRPRFIPPQLGFVKNPLFWSVSVTILLQGFSYFPVSLYIASFTTAISSPLTATIVLSVFNSSAVGGQILLGHLSDRFPYPWVMCASALGSSVVAFLLWGFARMSIQLYFFAVIFGALSGGFSSTWPNAAFDCAGGKPEYTGIAIASTAIFKGISAVVGPILSGILLEAGKGSSIGGVFGREGYGFVEIFVGSCALATGAGSLLIAFTRQRAGIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST44</accession>
    <name>A0A2G8ST44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 13">Chitin synthase</fullName>
            <ecNumber evidence="2 13">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_00643</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 13"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST44"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST44"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF11">
        <property type="entry name" value="CHITIN SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="679"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="851"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="15">
        <location>
            <begin position="121"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL36951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="885" mass="99651" checksum="AF85D2B54FE3C20D" modified="2018-01-31" version="1">MAQDQRPPLPSLTSQSSGTDSNTLTDPFADRQRAINFSEPRFPTPNQSVTSLPNEFGTLGDYDEEESEKLPLNAGGTGYPPFDPNSYGDPYGARPLSVASSSSLGVESQWRRRQTIKRGKTRKVKLTKGNFITEYAVPSPVFSAIEPKWQQSSTTEFSHMRYTAATVDPDDFTEANGYSLRTKLYNRQTELLIAVTSYNEDKTLYARTLHGVMLNIRDICKTKQSKYWRRSAEEGVPGWQKITVALIVDGLEPMDKTVLDILATVGVYQDGIMKKQVDGKDTVAHIFEYTTQLSVDATPQLVVPHGDDANNLVPVQIILVIKAKNQKKINSHRWLFNAIGRMLEPEICVLIDAGTKPGRKSIYYLWEAFYNDPHLGGCCGEIHAMIEGGRKLINPLVAAQNFEYKMSNILDKPLESSFGYVSVLPGAFSAYRYRAILGRPLEQYFHGDHSLAERLGPKGIYGMNIFTKNMFLAEDRILCFELVAKAGDRWTLTYVKPSKAETDVPESAAELIGQRRRWLNGSFAASVYAIINFFNLYRSGHGIIRMFFFHVQAFYNVVSLVFSWFSLANIWLTFSIIIDLMPTQGIYIFGTATVTHWVNFGLKALYLALLALQFVLALGNRPKGERMTYNITLWVYAILAVYLLVCSFWLTALSFKSIPDKLKNKTTSQVIASFFEPPIGALIAAILSTFGIWLIASLLYRDPWHLGSSMFQYLCLAPSFTNVLNVYAFCNLHDVSWGTKGSDKAEALPSVSSKKTKDAEVVVEDTERNKEDLDQMFKETVTRALTKIETKEVIEKPTMDDENKTFRTRLVAFWLLANATLSVAIESLNGIGTGNEAEDEAALHAKQNTYFAVILYSTFALSLVKFVGCLFYWFKRNLFRCCRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU37</accession>
    <name>A0A2G8SU37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU37"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU37"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="184" mass="19257" checksum="FBDA730E960220B6" modified="2018-01-31" version="1">MLSLFRAEEGEEELDIRRRIGLDVLPDRADPGSGVSGSQMPLDAGRTSLWNAPRPSIETGNNSGTLSLLARDTVPMQVDAPASPVIIQPSQLPAPPSVGLRHPQTPAPPVNYPAETGDMAQSPPPPPDPLTSGSGVVGPKSATVSVPPVTHATTVWTPMDQDDDSDNVDEPMPTIDLGSDSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUC6</accession>
    <name>A0A2G8SUC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUC6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUC6"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="406"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="809" mass="89970" checksum="A88C716FE443D05A" modified="2018-01-31" version="1">MDKDLLSELARQLHLPPNDSRTMPSGALSALGRVPPRRSPPQFHPGMTKEQTAQYIRDYKDWFEEDRKIPPESAPLVDPLSLIAEQSHRRAELERSTGRHSGSSGVPIFTTIVGFPKHSSTTSVESLQPVTFAGMLVRRAHVGQYLLCRIVAPCCRMVAVQTIVEDIDGRVHDLSIYNFPSTFDCDLKHVDTLFPLGAVLAIREPTFKAPLQGIRPIIRVDSPTDIVFVVPDSPILHNVAWQTGATVPRSPAEPATLDAWRQRGNAYFNSAQWFLAAWAYSRGLVVDPDATVVRSNRAEVYLRLNYFSGAAADAQQVLATDGIPDGLSDKTTFRLAKAEYGRGEYDAAVGHFTRWQECHLKDAVAAPWIQRCQARQAEKQTGQYNWVSMFREAEKEIRLDVADFVGPMEVSQMMGRGGGRGAVATKEIKTGELLLVTKPFASAYASDLPQDKIIITLDLISNISRERTDAVLMAHIIDKLYGNPDLRDQVYHLYAGPDYPSPPSSYPPPLDQATPVDLFSPRTNIDIAQLEAICIYNNFCPLRLEDNQVTENAKPTGLYPLASLFNHSCGANSIWYCIGDVMIVRAAEPIPSGAEITIPYTVEESYVTRQGILKKHMQDHCTCWLCEEDRKDGDERLRRRHALNEMVSSHKLTSASLKEVQKFEKDVRETFAPTRGPVRPLSALALHVLAEKLRASGNPRLLRESLEEGMNALQCLGFEVAEGALGQNELPIGTDRIPTVTSFLEPCGMMFRIACTYLNLREQANAVPWLKASLWLTNASVGGGKDLFMLVHRTSLEQMGIRDLAVQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUY9</accession>
    <name>A0A2G8SUY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01082</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUY9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUY9"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL37388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="167" mass="17744" checksum="F7C09750FA89664A" modified="2018-01-31" version="1">MTDQYVDPKYARASYRPQNIMSPGLKRAREPFKLRNTLTGVVLAGFAVGVWAYSIGAVKQDDFGDVDEEARALMAGSGLQNSMNGVAEGKTADVAKTSPVVAPATTVAEPPSLPTPVSGTRRGILPPLLERRFPGLLDPQTGTLVWNAPPVDNVGKLRMAGGTKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVC0</accession>
    <name>A0A2G8SVC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01405</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVC0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="109" mass="11925" checksum="E3D37FC1098F53B2" modified="2018-01-31" version="1">MKTPVSSGRVRTLSAEIVSILGVILRTGTTRRTSHRLNKFAERLCFDSSDSSGALTPFYAKNPKLRAGSIWWKAAFSRISSISKGPLSKCAVDYYQPEDDATLPSERGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SW60</accession>
    <name>A0A2G8SW60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SW60"/>
    <dbReference type="STRING" id="1077348.A0A2G8SW60"/>
    <dbReference type="OrthoDB" id="2501127at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20084" checksum="1906ECFA034D56E5" modified="2018-01-31" version="1">MDAIHTVIRLPLYIILWVFSGLLFILTAVRLNYTLHLPRGDPLNHGRDFYDPIVAELLVVSLMTLGTIPLVKGWVPNFNLVTSTASRNLFELVGLSVLWLLWLVGCVVSTSIWPSLSFCYQFEPCRVLTAMMAFAWLGWIVLVGLIVVAILSAVSKVRPARAPMMVEWASPSQMARSVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLF4</accession>
    <name>A0A2G8RLF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLF4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLF4"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="676" mass="75350" checksum="79C82A9ABBCD1D0D" modified="2018-01-31" version="1">MSTFVSHIVADLSRKALPANAPSTSTERVQIASSQSKEALRDIFIKLEQSQSPENLRKCIDALHNLEYHQQLLSAELADNEEQTLRRAILARVALGLYCQALSTFLDEASEAETEMQWWSDVVRSRRRAATYLLQTLPHRVLNVSNVVLSTLRTRNIPVHLSVLKPSSLRRLFPSTSTLRPNTLTLALFPHLHHEPYSIALTSSYETHFLVSSSPTQTATSAYGAFTQTLYGVARVCGTLATLPVDLAQGECSFKHKELKRIRDERAEVLGLLVDLRDRLASALETADSDEALFELAQFVHYLQTIISGHEFSPLSEDVSPGRLLESLSVLANLSLPSHTSLHSAGLKTWELRRPSWLTLTWPRLFLLPPLVLYGIRTAYASRASLEELVRGTFETAKGFWEDWILKPLRGMVHTVRAGREDGVIVTKESVRADLESLERMTLALAAEKLQYSTPQLEALTRQVQMGDLTAVMQIYEEEIKSPLKSAMQGSLLRSLFIQIQKAKVDINQALSGIDKLLKSQELTFAFVGVAPALAIVYGLFSNLGRLWLGGMGRGRYGGKAKRVGVWSAMRRIERLLIAQPHPRHTRPHPVPALEKAAASATFVSPLTSGLLLLSVTHLRKYAETALPANSRLREGFLEDVADLENPSLGRADKLRVLDRMWRSWGEPLGWSRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLI9</accession>
    <name>A0A2G8RLI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLI9"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="482" mass="52554" checksum="1D994FC87B45FDF6" modified="2018-01-31" version="1">MLADVLPSDIWISVLHYLSVANLATLAQASRYFHALVNEYGWKIHLKANPRHTWSLAKSMQLLDPYAQVRYNTIADNNWSEPHFVARPLASKWTGKLQPHLAINKSRLFVAAASHIYSYTFGRSEDSGSAPSIQFECAYMTNKVLQASRDITSIQCVPDGGFDRTVYVGYADGTLERVVLPACKPGAQSPVHPEAPLREKRAYHGTDAVESISTDGDHILSLSSNGTAVFFSNSVTDPAPQFIELRVRSWATHLSKRHAVLGASSLTPLTVHALQESHVSPTPSHILTTATHDDHPRASAVYGISGAPPSAPWGSSDNVVISGWYDGVVNVHDLRSSRRASRIPGVSSYPAGGALYPVMSMFDPWLFEPVYDVAAGGGNACHIAAGTARHSVVAFWDVRAANRGWSVHAPGNDSSPVYSVKLESSRLFGATQSRPFVFDFGPGAREETYPTLTRPMKEDGLKRRDSSGVGFYVTKYGHARPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM64</accession>
    <name>A0A2G8RM64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_15297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM64"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM64"/>
    <dbReference type="OrthoDB" id="3262409at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="352" mass="38567" checksum="101C7942BE17A60E" modified="2018-01-31" version="1">MADNPPQPPVSSETLLRIGPILIGALLSWMLFGISIVQLYIYHVSFPRDRFAIWGSVYTIFALDIFQSIVVACEAWQTLCAGWGRSVNLQFPGWTFTALPIVSSIISVWVQTFYAWRIYRLGKWRVIPVIIIITALAQAGGACAIAISFIWLKDIQRLHDTNMFARTIVWLGGSAFTDLTIMFSMCYLLFNVKRKTTAFARSELLVRRLIRLTVETGCACAISAVLELGFFLGLPDTNIHLIVALILSKVYSNTLMTSLNSRASISGNRSQKGSTMTTIGFRNVGALPETEDESASRGVPIHISQATDSSTAASGSPGTPDDKFASSWDVEMNGMRSSAKGSDKPASGDTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMC7</accession>
    <name>A0A2G8RMC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_15355</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMC7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMC7"/>
    <dbReference type="OrthoDB" id="415315at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="181"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL22663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="280" mass="29685" checksum="B09F4B9AAAF01A4C" modified="2018-01-31" version="1">MSIQSAPTFSQSLVAGGVAGTAVDLLFFPIDTVKTRLQSSQGFIRAGGFRGVYKGIGSVVVGSAPGAAVFFCTYDTLKKTLPLPSDYAPVTHMISASIGEIAACSIRVPTEVIKTRTQTSTYGAAASSLAAARHVFSTEGLHGFYRGFGSTIMREIPFTSLQFPLYELLKVRLAKVLRRPLHSYEAAVCGSFAGAVAAALTTPLDVLKTRVMLDLRDPAKHAHPSLAARFRDIYVKEGVKALFAGVVPRTLWISAGGAVFLGVYEQAVQSLMGGPAQPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMF1</accession>
    <name>A0A2G8RMF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_15387</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMF1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMF1"/>
    <dbReference type="OrthoDB" id="2687058at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF0">
        <property type="entry name" value="K(+)_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="9">
        <location>
            <begin position="76"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL22694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="961" mass="102880" checksum="52365F93E26EC25D" modified="2018-01-31" version="1">MPQFSAAVLAIARRVIHRRAAAEQASPTRPSLLVSVQTDVTRRLKGGLLNGQDPTAVNTADPLRLWIVQVGVIVLTTQLLGLALRKIKQPKVIAEVLAGILLGPTAFGRIPGFTEHIFPVDSRPFLSLVANIGLCLFLFLVGLEIDASVIKRNARLSVTVALAGMCLPFGLGAALSVPLYHIFIDQSVKFTNFMLFTGVAYSITAFPVLCRILTELKILDTTVGIVVLSAGVGNDIVGWTLLALSVALVNAGSGLMALWILLVCVGWTLFMLFFMKRVLYWLARRTGSTRDGPSMFFMTVTMLLVFGSAFFTDIIGVHAIFGAFLAGLIVPRDGGLAITLTEKLEDMVSIIFLPLYFMLSGLSTDLGLLNNGITWAFTIAICSLSYFGKFTGCTVAARVAGFNWREASTIGSLMSCKGLVELIVLNVGLSAGILSQRVFSMFVLEALVLTFMTTPAVVLLYPPELRVRASATGANFASADVQGTAEDNDPRLDGPSTARTDDKKSRFTVVLDKIEHLPGMMAITQLILPPPPPYSEHTLSIQSSAELDGKDVPPPPPIPPVSIDAIRLIELSDRTSAVMRGSNIEALTATDPLLDIFTTFGALHGAPVSSSLSIVPFDDLGATVAEQAQRTEAHLILVPWLPPHHSLGAHESHPHHAPHSSAQQATMATPLPTPRVTSHMQNPFEALFRATAAGAEERDASISHSHFVRALFASSRTDVALFVDRHTPGGVAKVSHGGTYRLLVPFFGGPDDRLALDFAVQLCANPKICATVVRVSKADVVVGGAGLGAGAGDKLPAYGEDDRKHAGDLHQHQNTTTIASVFPDTVYGHATTQTRLQSETADNIAWARYTQPTDPALSPALARMEFVEEAAPAPLHAVLERARKMSDAAVEEHSRLLVLAGRSRRFAVENHHAELKTITEEYGGVGGEVKRTVGDVTTALVVSGCQANVIVFQAALTPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNF8</accession>
    <name>A0A2G8RNF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNF8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNF8"/>
    <dbReference type="OrthoDB" id="2753482at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="376" mass="41938" checksum="DB242B9A72FD68D1" modified="2018-01-31" version="1">MRSVDEFVSAAHTNTYPDTHRVDPSCSTPLDSDALLLCGTLGTISYDNFSEQVSPQPGETSAILWMAAADQHLENDFSSFQPFVQYTGPALFNTPSPPEELLFSPSQWDDASHPNTSSAHSYYTDQATSTPGHPYWAGLNVVAAYPFLNDFWSDSIAGDCANVPMWNDGMAGRGIEQPGYLSVDDSRHVPGSTLFTDHNIDFSPSPRITAHSESYDVYPSPPLTPESRLHGHDHRHPISLPTHCPPAAPPAVNPWKCPHCNYVQGRRRMVDLKRHIATHTKPSDVALWTCCGYPREAARSKGVPDDVIRETSAIYGRVGGCWETFSRRDALQRHLRKQKGRCFGDAYAEWHPGNSNKRDRQTKTRAHAEDSYQWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNG3</accession>
    <name>A0A2G8RNG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNG3"/>
    <dbReference type="OrthoDB" id="2753489at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="228" mass="26298" checksum="A750FA14406AF0D6" modified="2018-01-31" version="1">MSGPSDRVFFRAGYVTSLDAWERYLSDGHGIRLDADDDAPDCEWLPDEDDEEFEEGQESGEPTLPEEDEPLLAKQRSIFNRLSDYQGNFRGLYRAAPPEVKARLVLPHTFTRIIKHPELGGTYHEWNLFIPTSWSSPSMRTKGPGDVDRQRIQAFVEEANGLIEDHERREAAGFKFQEPDFKFERFPDWAISRPLLSDKELSNLIHAGPDSMRLWGISPREFLHPYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP64</accession>
    <name>A0A2G8RP64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP64"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP64"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="6"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="206" mass="23316" checksum="87AFE26EC16F32B2" modified="2018-01-31" version="1">MAAAMQAVKRFRMRELAPLLRNDAKLSNPRPNVRSPFLPHKSADTGRWSSAKYSLRRQADLVKNARASGTLHLLPPGPKLSLAELATASQAAAASTAQASSSVVEVAEQEAKAKGKKLWDMPVEWKGEYKEKEVKGADVGNRLYAGKKRMFKGHKWERTQQERHREQKMLMRDMKARIERFKTTYRRKTPSPVSVARPVSYSKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPD6</accession>
    <name>A0A2G8RPD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPD6"/>
    <dbReference type="OrthoDB" id="3250682at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="216" mass="23121" checksum="C49FD7FCA0A0C7F3" modified="2018-01-31" version="1">MPIHVVMSADTMFLVLGMMNAAGSISYNDLAKILPIPTVVLATGNTMLCTALIAGRLAYLDHLINGHLQFGVAKRLQSYRGAILMVVESGAVLATANVIGMVLLILQHPGLHVMLNITTQLTAIVPTTIVVLSHLHLILGDTANQTVSVHFASNPEHSANFHSTGRAYSGPDSNPHEEFTCELTETTRSPSALDIEKQIRLLDPSPCPSRGPTVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPZ0</accession>
    <name>A0A2G8RPZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPZ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPZ0"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="171"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="579" mass="63235" checksum="C127B792E011BADF" modified="2018-01-31" version="1">MPRSRKHPYQADMPYAKQPLKAIYVVQRLFTSIVMCIWWAAYYSIMPRRYRPRPSWTIKCILAVNFTRRIYKVTELAGVTWGTRDPEKECDERSLKHTRFEWVDPMPQELRTGIIADPQVPFRRVGCFVWPKERPSFPCHDLDSGLSSSSPSQDVLMDFEAAAGDVPVIGIFMHGGGYCHMSAHENAPTSQIPGRLIKDGAFKEIHSVEYRLLQHAPFPAAVQDAATVYAHLSGDLDFLDVEGWSPERVKNRKENEEIHARVSEAAAHVACKIILIGDSAGGNLVLALARWIRDEGVLPPPDGLLLLSPSCDPSHAFPETPSSYIPRPHASTDYLVDTPEPRALLQRTFLGHNPLETMHSPYVSPASMRVLAAFYGDAFASSVADLSIAQLDDDGHREFLRTMVSAPVTPVPMASRANTNTDTDMSTSLGPFLVGPGPPVMNASPDTSNSNSSSGSGLGHDAGANVPGPGPGPGPGPGAGVGAGAEGGRSPTSLAQPVIASPRGLSLFSEFARTCVVLGDAERLEREVAKLVGAMERDGTEVRAIWVRDAPHDVLQMKWWDERVRDGVWAQIEEWVVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR06</accession>
    <name>A0A2G8RR06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR06"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR06"/>
    <dbReference type="OrthoDB" id="2681631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="290" mass="32867" checksum="EFAA1AA9F434EB85" modified="2018-01-31" version="1">MPDADQDDWKSLPEFTEVTKNYTDFQDAVYALYPGVTKDCEFTTTDVHRAIDEQLRVKYINDVNDYSRYYVKLRPMLANLLKKSRITNLEANQFLADALDPSLKPLITTRLLHAYSNRTADTPYTVEQFHQSTVYVFFHRNDDAEAIFRSPGSSSRTVGTPVAPAPVPVPATAPAPPIPQALPPIKQEDVKSLALLLQQQIAENWHNQGPPRDHPPHMRGGFGGYGGGPNYGRRPMRCYYCGKENCDTKTCPEVMDDIRAHKIRRERNQIVLYDGSPLHVGFNGQTMREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR59</accession>
    <name>A0A2G8RR59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR59"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR59"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF34">
        <property type="entry name" value="LYSOSOMAL AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32673" checksum="6AE5E3A383C76AD6" modified="2018-01-31" version="1">MFTPLDESPDVISRGRPEVRAADLSEDTEEWRTASFQRRDSRVSRKGATMVFMGVWALFGVGTFAGDRLSPSGALVQGTGKVLAREDYPPESLASTYDAVIDPRLADPILSAQLAGGTTVLEFTHSIDFEGILSGQAEPHPSAPSLEFIIGRISAWICTTLYLTSRLPQIWKNFVRKSIEGLSIYLFIFAFLGNTFYVASILTSPKLQLPPPQASAFIRESIPYLLGSGGTLMFDITIVCQAILYRQKGGPSRIRHPSRSYDEEEAGLLSAEATGAHEESPVISRRRGASITPEPGVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRV3</accession>
    <name>A0A2G8RRV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRV3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRV3"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="4"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="21932" checksum="E89E6BCB8864FBD4" modified="2018-01-31" version="1">MSGICRARLAEERKQWRKDHPFGFYAKPTKAPDGSMNLLEWEVGIPGKAGTPWEGGVYKLMMIFPEGTASSRRPCPLSIEASQVQIHSTTLPPQRIPFGHRLSVHSRRREVLETRDYNQTGIAWYPGTAQRPQRERPRAKRCLHDVQERQSGVRTPCEAASTREHPEVTRYLSSYRFHCIVVVGLFLLYMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSY6</accession>
    <name>A0A2G8RSY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSY6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="158" mass="16729" checksum="CF84CDAB35DB3B1D" modified="2018-01-31" version="1">MLIFNVLHIALSFASVGYNASSFTSNVTAFTQPYYPYILPLRPPALTPLIFVHIRITNILIARFLIDLQATNRAVVNINDPAGTSQASQQSSAVMASDADSLRFAGFIGSIGSVLTGDFGRADVEDADEEQEHPGPGETPQPAPAPGGSQRSIPGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT14</accession>
    <name>A0A2G8RT14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12508</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT14"/>
    <dbReference type="OrthoDB" id="2803471at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="128" mass="14417" checksum="291C0AD60DA86714" modified="2018-01-31" version="1">MDPSTIITVLSSFQISHTIGFSALAFLIFDHLLTFIEEVDLFWKPKLTGAAVIFFLNRYIVLSTAFFNNFGFSLVVSPKVHFAFGANGQYDTVFGCIIVDPIDLVLSQRCAYHSRNSNLLLPQLVFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT35</accession>
    <name>A0A2G8RT35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT35"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT35"/>
    <dbReference type="OrthoDB" id="2757137at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="160" mass="18020" checksum="31F8299ECB5E9784" modified="2018-01-31" version="1">MSSYDPTTVEIFYEFLVEDYCLVATGAFYIYDILLTLDVEVEFFWKGPFTGAAALFLTNRYLAFANLILNFFQLMPYRSDKIDCLNIDGIAFSTLRGYALSKNWPLAMLILVLSLVPFGINMADFGFQLSGFVDPVFGCVTTDTESLSISKNCEFHIGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTH9</accession>
    <name>A0A2G8RTH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_12711</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTH9"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL24825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="58044" checksum="D930B0DA501CE7F7" modified="2018-01-31" version="1">MASLSVASACAIAAIALILLLARIRLWKSRSHLPPGPKGLPLIGNVLAMPRTHLGRHFARMGDRYGDIVYMDILGQPMIVVNSYEVACELLDKRSATFSGRPQLVMAEMVGMEWMLVLMQYGKEWRRHRRAFHQAFHSEAVAQYQPLQLQMIRRLLARLVESPKNVVQQLNFSFASTLMQLVFGIEISEVNDKYFAMAERVRDIGEDVAFPGRYPVELFPWLRYLPAWFPGSHFKRIAEKARHEAESIRTSLHTISTEPSDSDPARDSLVSRLLVSASREFPLLDDLEEFIKGVSTTAYATGVDTTNTISQVFMLMMAMHPKIQKKAQAELDAVLGASRLPDFSDRSALPYMNALIMELFRFHVVAPLGIPHRTIADEEFRGYFIPAGTVVSPNIWAMSMDPNEYSDPEAFNPERFLDTERQARDPRQYAFGFGRRICPGRHLAEATVFIVCASMLYVFDIKPPVDSNGAPMELEYKVTNDTLLQHPLSYEYIIRPRSVDVEHLVGEIEGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU40</accession>
    <name>A0A2G8RU40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_12907</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU40"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU40"/>
    <dbReference type="OrthoDB" id="4243at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="83"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="99"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="283" mass="31562" checksum="2F286B5F285999B2" modified="2018-01-31" version="1">MGQAASQSVAPSSAGPAQCPIDHSAQMSTPAKCPISHDKPAASSSSSSRPAQCPISHEKSKPAQCPIQHDAAGAELNPLNQMPALSQQPAEQQLAALPTDRETSSIPRDEGGSKWEYPSPQQFYNALVRKGWETPEEHVETMVQIHNWLNEQAWEEILRWERKENPHAVEPQLARFKGRPGELSPKARFWLFAGWLLPSRFNTEPPFDRHDWIVRRQGGQEVRYVIDYYSAPPEPDGSPVFSLDVRPALDSVGSIKQRIQAATEDAWATFREENARNSSQSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU48</accession>
    <name>A0A2G8RU48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU48"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU48"/>
    <dbReference type="OrthoDB" id="10587072at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013876649" description="Transporter" evidence="3">
        <location>
            <begin position="30"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20193" checksum="55E3D1D1F9B461F3" modified="2018-01-31" version="1">MLENPIDSTPMIPRLSALLIFSLPLLVAAQNDNNPFDNGSGTPGAVIAGVVVAICIAILFLILFGLMFRRRRRAATVLPQYSSASGVPESNQNQGPYLSYPMNQQQAWGGHHSPPRPPREEFAPPPPYPGKREPDGTEENSGYGYPNPPPPDNGVLASGGFINPSNPHTHTPPPAHVPAHSNPKAGPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUB5</accession>
    <name>A0A2G8RUB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUB5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUB5"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="382" mass="41604" checksum="ABCCBF50E2EB2F2E" modified="2018-01-31" version="1">MSQILPPPPSSQTELGRYRLLAPSAGVRVSPLCLGAMSLGQAWAQAMAGGTTEEEAFKFLDTFWENGGNFIDTANSYQSQESEKLLGAWAKARGIRDQLVIATKYTIGYKNDDADVKLKVNYQGNHRKSLVLSVQDSLTKLQTSYIDLLYLHLWDYSTSIPEVMQALDSLVKANKVLYLGISDTPAWLVVKANEYARAHGMAQFVVYQGLWSLTTRDLEREILPMCRAEGMGIAPWGVLGQGKFKTEAEIKNRSAVRYNVPQTAEEKSVSAALEKVANEVGNGATLGSIAVAWAMNKTPYVFPIVGGRNPQQLEEVIKGLDIVLTTGQMKLLEDAAPFELGFPYMPLFGTDPALGDGRPGYFVSVAGPVKYVKASAPITPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUC9</accession>
    <name>A0A2G8RUC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUC9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="12296" checksum="04F06C27AA91439A" modified="2018-01-31" version="1">MPKACLSRTRDFREVLMRYANPVFSEGISSSLFPWRRWMRILEDGIGNCQRWMEARAVDSRWYVPLFVDCNTSPREYVCQRIPICPFFLSPTPLPRGQAIPPSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWE2</accession>
    <name>A0A2G8RWE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWE2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="11261" checksum="7E0F627370DD34EA" modified="2018-01-31" version="1">MSEAPEKPDRIPDREEPQQTSEARREQGPDGGTAAGPRPTKSVNARRVLSARLAHEDTSEAGMKPLPENTRSEQGQTAKIGRRWVGPCVARGGDEGTAESASEPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY49</accession>
    <name>A0A2G8RY49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY49"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY49"/>
    <dbReference type="OrthoDB" id="3354175at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="162" mass="18218" checksum="13F7C151A435D35B" modified="2018-01-31" version="1">MTQIEELDVIKFFETLAPWITSFFALSLTTNMLATGEQFNYNMRKYQYRAGYPGVVVANWGVVELVVQSAAIYTCVLIRFLGTYLSGSNVQYIFRDALQPLIGFVFTLIIIRVRLRDATTGEMATARGRSGSNLISNRGQDRRLYPLRPVAINVSVSQTTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYA4</accession>
    <name>A0A2G8RYA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYA4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="251" mass="27892" checksum="86C1F21326893463" modified="2018-01-31" version="1">MSAVLNTFPEAARLPGNNESVLPLPLPQRAFTFDSFADCRPHAGPPLARVVQSPGTLDIATQHARLAMPKSCQNLFPNGERDATRLFNINGRVAAAWRGEPNNACCHLSSGARVTLFPLDQVGLIDEHHVQEYRLTTWTSAVAFTAFVLASARPKLHGPLAFLDAMLPNNVVVWKAWKEAMARAAVLKDREYVNGDSGEHRTAPEDVVPPVFSDADLKRVDKEYQGLLRIFFRDADDAWKAWWKPVAIRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYJ6</accession>
    <name>A0A2G8RYJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYJ6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="151" mass="15843" checksum="4608B0BC87E5E3C9" modified="2018-01-31" version="1">MLIYIYRPGVFGRAEPAFVPGLGLRHLALEGVPSPGAAAGASAAAPERLPERRDPRAHAPRPRPALAIAARPRAAAARRAHARPALSGHPDLQKGDRGVAAAPARGAEERALSAGFGVGVGVGFRGGSCRRELEAATWRECRKFGVELVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZI6</accession>
    <name>A0A2G8RZI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZI6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="132" mass="13032" checksum="DD56AF8DAD55CD04" modified="2018-01-31" version="1">MSNTPESTTTNAPKGGSTSAGAGAAKSIYQVSVEQGAPPLTHPPDAGDSIRENAMDFLDAMFGTPRHPQSQPQQGADEPRPGVGATRAEAGEEVGAAFSKATRKVGEDAGVTRGPAAGTITGRATGGGGADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZN8</accession>
    <name>A0A2G8RZN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZN8"/>
    <dbReference type="OrthoDB" id="10521039at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="189" mass="20121" checksum="0781FABD7E4C7E29" modified="2018-01-31" version="1">MIGVFFSVPAATDAVRVQYLTSHVVDPVLGCSPTDNTPPDLELILLMVLNATDLVFVTYAIIRAKRGISDSDTDALGAISVFRAFLPSVLVSHFLLDLQEAHQRKVVVLASRSSLETSSSDSRDSFARQLPAALGALGATIDPADWDLPDDGFEDIDVGEDAHAAFSAQRRVHPADGGFTQGSGSMFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZT3</accession>
    <name>A0A2G8RZT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZT3"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="37796" checksum="64AD15AB62EE4414" modified="2018-01-31" version="1">MYEVSEADIQRILEHHRGRPTAVTEFSQIKQDGFDAFTSTRTFLARTDDGTSYILKTAVASPASESYLPNSLEMEHTFLKLIASQSDIPTPTIIAFDPSASLAPYQYLLLAHPGGVPLALVRASGKLSPRQEALLDLRLGSYLKELHERVQNDWFGLPSQEKDELYSWQEAFTLLLETIIEDAHSAEIALPYEDLRRYLSRAIGFFLFDDCEVPSLVSLAGDEYSTFVDFDLGKGAPEEQEVRITSFASVGHALWGDPLLETMFLEPSAAFVEGYGGPLIVFARQKTKRMWYTLFLSLVVLVQAKRLGLSEADHEKVRWAKETVEKCVVGLKDTPCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0K0</accession>
    <name>A0A2G8S0K0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0K0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0K0"/>
    <dbReference type="OrthoDB" id="2953893at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="157"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="299" mass="32597" checksum="ECE6D296F7F4C82D" modified="2018-01-31" version="1">MSLKRPAVYMIFATEWLQTILITDDAFNKYALHYGDVNNLVKLRLAWFSVPVLGGIVSAAVQLYYARRIWLLSKSNVLAGVIAVLSLAQGAAGIASGILVKNRPASQASSQDKSLPAISVSLRYREYNAFVHADTPDQRRIKGTPACSLAQPTPQLLRTRTGLKHSDTMVMKLVRLVIESGTLTATVAVVAVVLFAALPGTVYYEFPSLILAKLYANTLVTSLNNRAFLHKLRPNVNTMSGSDSAPSHSRVYNGGIASTHRHSRSMVRVDVLKETRVVADYELGSFPVGAMSSFLEFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1E2</accession>
    <name>A0A2G8S1E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1E2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1E2"/>
    <dbReference type="OrthoDB" id="2782214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="272" mass="29658" checksum="E9B825E1590397D5" modified="2018-01-31" version="1">MSLSTSFNDLNYEQEEFKPFSTPSPTSQSSPQSSSFQTSYVNASTSSPYSPHGIPGHGSGWQSHMSDPRMTRPRSTYPPVDPLSITSTQRHQSRADSFYSGMDSGSYGMRRTPSSSPPYPSLMSSGHYTASSTGQYHPHYSYAPPLPSHHSMSGPASTESRCEWGPGRCDVALEDTTPAGIARHLRQYHDIAVTDNRNRGMCAWGGRCGKDMFPSSFGKHIAECHLRNMTKQCPYCRADFARADTLSRHIKAFCPHTTGGGGGAQAHPHTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1N4</accession>
    <name>A0A2G8S1N4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1N4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1N4"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="560"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="666"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="847"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="859"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="889"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="921"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="937"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1122" mass="118431" checksum="43C03BCBF35C2DC6" modified="2018-01-31" version="1">MVSPAPLAPANPPLSYADRARKAQQNARPTAPQQPLSRSSSQGTSSIAQAPSTTSASRSNPPLSNLSRPPPPGPPVVDSRIPTSATSAKSTSPPSLDLLSSDLKPNGDVNHHNDSLSSVPSPGTTQKQSSAPPVNVWNKRKEQMAATRALTQSRSLQPSQPSSSSMSASLAAASSLSSPPLSSLDVSAAPSSSASASISLKSSPTMAPVSTNGHIATSSEFDDPFVVKPGRSPSILNSTPPSIVTPPAIDDAESWPEVGHAATLPANANNGRVEGRAKETTEEDRGHERETSSGQGSRKNEKPKWVPAPEELQFEGQPRGTVGYDILIIWTGVPAAKSDPFRGRSSADAITCGISFTFADAKSNRKCSIQSSTCEYTGRWATFTRRPQPLPAEFIPGVGLRPYVNTNVTQTQPAVLSAIPDSAISATADMNPHAAYYHPPHGPPFGVSPYHSPRPAGSPANNPYPLPPMGYQGQPAMPPPMHMSGYGTPPYPMYPPYGYGYGQPYVYWPPPGAPPAQAMSASPMTHPQQSDGVPPPTMLARPPPPHESDAVAGYRDVGFALPPPSEINRHAQGQVQGQGEERERGRRTRELSFGSIDAGAEGTSKSPSPARVSPMLGSVPEGAALGLDVSGGQGAAPTNILAGAAAASAVEKEKEQQDVTKAPSGLLIGVAPGEPTPSRIRSRTHSKGPAASTSAQAECSIAGGSLAEQQASGAAAEDPVAALTEAAKIIHVTDPLPETKWEFGTTRQTEGVADPQSEFSPPTAPPPVVDPSVPGAVGIPGANFVPMGLPYAGAPPFIPPVVIPGGPVNGIPSASSPSSYVPPRQPHSAIEDDWEVRDYGYGFGRGGPSVYTQAPAPALREDRPYRGGRDYQGDREQHYSGRPRRGSYSQGGYGYERGERGGYTGRRGRGLPGGYGGRGYQNRSFSRGAYSNQQSRQQAYVPPAQQQPQQQEANGYYAQPMAPAPLATYIPQAFEGYPYAPLPPPPPGVTTSSLSVPFPMPQSNVGFPLDSTRYYLLGQLEYYLSPQNLAQDFFLRQKMDARGWIPISLIATFNRVVNLTTDVQLVAEVLALSSMVEVRSGHVRMLQWQQFVLPTAAQSQIEDANQNPDGEDEDEEDVVFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S213</accession>
    <name>A0A2G8S213_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S213"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="47850" checksum="BFBB465094733C15" modified="2018-01-31" version="1">MIEDKYIGLTLAVSSSLAIGTSFILTKKGLNQASEASAYSSSASDSYTYLRNPIWWAGMTTLILGEVANFAAYTFAPPILVTPLGALSVIIGAILASFLLHEELGHLGRVGCSLCLLGSLIIVLHAPPDKEINTVDEILDYAKQPGFMMYCFTVLVFSVVMIYGVVPKYGRTNPLVYISICSLVGSVSVMAIKGFGVAVKLTFAGNNQFSHTSTYVFGVTVVFCILVQMNYFNKALDTFSTNVVNPMYYVGFSTATIVASVILFQGFNTDDPANSISLLAGFITTFLGVHLLEISRKPDPSALPGGHPHTALEAGLMNPRLSIHGRMSIDGWGGAAGTPIGSTMPTPWNPGHGHGQGHGRRSSLYRHQTQTLFQAFEEDEDERGGADGLGLDTLREVEDDELEADERTALRSGRRFGNGNGNGSAHASPRSHSGSNTPRETRSPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2F2</accession>
    <name>A0A2G8S2F2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2F2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2F2"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013607406" description="Fungal lipase-type domain-containing protein" evidence="5">
        <location>
            <begin position="31"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="117"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="320" mass="34214" checksum="522ABA188A6AE75B" modified="2018-01-31" version="1">MARSRSSKARLSMALAACGLLSSGTWQAAAFPTWLKHDSEEQASITALSTAQIDAFRPYTHYASAGYCSPASTLAWDCGRNCRANPSFKPVASGGDGESTQFWYVGFDPRLKEVIVSHQGTDTSKLFPIMTDGDILHVPLDEKLFPGVDRRVVVHGGFAATQSRSAPGVLAAVQKAIAKYKTKKVTVTGHSLGAAIGLLDAIFLPLHIPGITTRFVGYGLPRVGNMHFADYVDEQQRATLSVTRINNRKDIVPILPGRFLGFHHPSGEVHIDEAGVWLACPGQDNASAKCTVGDVRNIFVGNGTDHNGPYGGVKMGCSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2K8</accession>
    <name>A0A2G8S2K8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000031">
        <property type="protein sequence ID" value="PIL27991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2K8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2K8"/>
    <dbReference type="OrthoDB" id="25778at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="277" mass="29294" checksum="22B05BB194FC6D5C" modified="2018-01-31" version="1">MKRLLTNQFHVVCCNYSSFRALPQPRPVYALSNRILTYVSPLSHPDPVPSATPGQAHTSVPIAAPDAPLKFGLGMSQANLSNAAVKIGGSVLLRAPVHHKRSQSGSSSGPAANALGMLFSKSAPAGPASPHEYQTAADPRRRSLRVSLPVEGIGLRGFDCQATLTPGSLHPPLTSPVALAAGWLTEAVVYLHPLLTSSSAQPDPLPPLSFPAPQALIALKFLPHGTSLALCPKDGHGIRVLQLRPGPPTLRQPPLERTLQDLRSRASKDGASQHQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3F6</accession>
    <name>A0A2G8S3F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3F6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3F6"/>
    <dbReference type="OrthoDB" id="10372221at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="652" mass="71585" checksum="8614DFD94D17209D" modified="2018-01-31" version="1">MAIGKAIGIDLGTTHWYALIWVAFKLKPDNRTAVWNNDGVEIIPNDQGNPTTPSYVAFTDIDCLIGDSAKTQAPLNLHNTIFNVKRLLGRAFPAPDIQSDVKRFPFSVIDKGLKPYIRAQRRGRMKVFSPEELQSMLLAYLKKAAEAYLNDTVTSAVITVPAYFDFAQRQAVESAATAAGLRVLRLISEPSCAALTYGLTMVEPAHAPRVLLLDIGGGSTNAQLFTMEEGILEVWGVAGVSHLGGDDFDSRLVAHLVQEFRREHGRDLTGNASPLFRLRAACESAKRTLSVETEANIAIDWLWPGVDFYTTVTQAQFEEVCQDLFRLVCDPIEKVLRDAHVEKAQVDRIVLVGGSTHIPGIVQLVSDFFDGKQVTRLDQDAIVAHGAALQAAVLSGQDSARLQEFLLLDVTPFSLGIETAGGIMTPVVRRNTTIPTRKMETFTTTFDNQPGVFIEVYEGDCAHTEDNTLLARVVLTGIPPAPRGVPRIEVIFEMDLNQHLVVSVTDTATRRSNKVAVQSEKRGLTDSEVVDMVVNANTAAARAAARARLVRYVDGLRDTLRELRPAVERADAWLEETQDVFVPEYDAQRERLEAVARPLAERFAEAAAGDGLDGVDIPEGDVVDEEMLRNWAVEVVGPDYVPPADPDVDMED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S411</accession>
    <name>A0A2G8S411_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S411"/>
    <dbReference type="OrthoDB" id="10468656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="372" mass="42350" checksum="8D1124CF7E62CE15" modified="2018-01-31" version="1">MDRPSAESPFPDSHLGSLLALLELGRVGDDPIDKPTPWAWGAWRNGLRSEYAPWQLNATRENTHMFDHARHHSRLFVIAYHASGRNLQDRVRFARDLTEGDGDLYKGREWLTSWWTCQRYGDIMNLDDRINDILTQNGVLTSVRSVVELDIAILSGTPHPVVVLGRALFGDDVWGSGPLRHPAVLRWLGHTLDITRRDWITIYNDNHRRVDRMRDMIYTMCQDVLTYVAKLGYIVDMMDFVRVDGRMEQVTHYRKILYAIEESMGAWGASATSALLPPNMVRTLARMPSEAYRKMLKSEVAKCLKILDLRAVQSSVMPVDVYDLLSRADVGFLAGEIEGTNEENAGHLALEWQDENTLAGLAFAKCTLPRVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S435</accession>
    <name>A0A2G8S435_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S435"/>
    <dbReference type="OrthoDB" id="2766640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="422" mass="44380" checksum="4299721E1DE57EDD" modified="2018-01-31" version="1">MRLRTVPRRTVCKTLAGSVVLLSFPVVAYGLQISLRPDPLTECETLTVQWQADSPATVAIVDEGQEPAQTLFHATVDAPTGALEWVINATGGAQLDIAVSTAVAGIGIGMSLQRVVQQGTPTCFFSTHPPSVTARSSSQPTAPVTSLSLSPVPPAPSLDSTTSPQVVAASTENSSSVSTAVLPPALPSRPSLSSGAAAGIAIGVGVVATTSKSCNDDPPGAVSLSRTSRPREDGSSPSPYVDHIDERRESPILDKERTRSDSDSLLVARASFMPARPLHRVVHLSHARQERVDGLVVSEKRLWESRGRTLPTSTSESVPGVEAGGRAGVTPEVSAATLGAERRYVAELLAAGGVRRANGRVEDDDLDENSASAVSTLPPPYSLHFGDKARTFSPFGSRWLELYAVTLHLSLQMLNGQPRQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4P7</accession>
    <name>A0A2G8S4P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4P7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="160" mass="17616" checksum="FD40C8097A7CC613" modified="2018-01-31" version="1">MTTLGTTEEVKRETDEYGHETAEELGHEYVPPYAPPLKTAGTGPRLLRLETLSVSALECGAEGWLVLLESARALVRLQVDVLPLMHEDAFALIVPSLTLVLPLPNGGTDNEGVERETPARNPSRDSKGKGRATDDVDQQGEEEEEEYKEVLIEQRGIRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Y1</accession>
    <name>A0A2G8S4Y1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Y1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4Y1"/>
    <dbReference type="OrthoDB" id="2644912at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="1">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="478" mass="53985" checksum="B12ACFD1AB2F9D23" modified="2018-01-31" version="1">MPTLYGEGHRAFRRLQEEILRRIPDQTIFAWTSFSLDSPTEHRGLELDSATFQQVSYSHDIPNLDRSSLLAPSPDLFHGCGHIEPVSHQEVIRRLQHNLPAADYYFTPHGIRTAFAMIPFSAYFRSGTVADLKNHYLNFIPSSQWYLAILECEHQDYPGHLLGCVCYTQRSNKDAVEFPYCGFVEVSFPTTPFDPSRPFEIALPTALFDPNRRFDLLPLSRASLKNASEPGARVKTVYIPHAEEYDRVFEVTRWTPHDTIKMVVLKRTRDELRAKGYAVELREPDPSHPNIHSLTLTKGSLTIAVEFQHTLTGGPDDQKLTVRNRVTVSGHTRGSSVMHSSLPWTRSLGFGGSHIAVDLPGIREFLLSNELTLATKDHYAIHVELRPKSSARESEPTREKLVFEQRKLEIRAGEMRVIGGSEGGSLARALEARSQWRRNYGPGGELDAVTPWRYGKREAGDVSEVIKEQPGEDSLSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5L0</accession>
    <name>A0A2G8S5L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5L0"/>
    <dbReference type="OrthoDB" id="2817141at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20971" checksum="97596930A81482E9" modified="2018-01-31" version="1">MVTSKPSLSQASPYGPQPTYEEYYTLQKTHDSRSGSALTFYAIHYADLASLSAQSASSSKSNPPPEDRFFIKVAPRVKDEQAGKALKQKLLNEASYYQNHLSSVQGNAVPIHYGVWKGRTEWGSDMAISIMQWGGVPYLGQIKGTEGDGEEVRKAVLKAFHTLHMQAKMSRSRLPIENALIRDICIYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S693</accession>
    <name>A0A2G8S693_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S693"/>
    <dbReference type="STRING" id="1077348.A0A2G8S693"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="291"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="410" mass="45641" checksum="E11EAC2596AC136B" modified="2018-01-31" version="1">MQPKRYVEPRFKPGEGKTKIALLFFSSGTTGRPKAVMIPHYSVIANCVQMKQYANTRDAALPNNQKIYGARDVGLGVLPWYHIYGIVVSLHFFLFCGMSLVVVSKFNFENMLKSIQRYKITHLTLVPPMVVLLCKHPAVKDYDLSSVKLMTSGAAPLSAELTHQVAKVLKNSRIGQGYGMTETCTTFSFPQLDMRIGTPGSAGRLIPGTACRIQKADGSWGGINETGHLIVTGPSMAIGYLDNPEATAETFKDGWVYTGDEGYVNEKKELFIIDRIKELIKVRGFQVAPAELEGHLLDHPDVADVCVVAAQDEYSGELPFAFVVLHEKVRKRVAKSPKDEERVRQAVFKHVSDHKTQYKWLAGVQFVDAVPKNPSGKLLRRVVRDQLKEAMKEGKIKLVQPGAKKERVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6D1</accession>
    <name>A0A2G8S6D1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6D1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6D1"/>
    <dbReference type="OrthoDB" id="3248709at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="22803" checksum="561A4038E43FA459" modified="2018-01-31" version="1">MSSRGKVLDWFKPLRSEALARLRINTVGLFGLTVLANLLPIPSPWRALDVVWGQRVGSGTYYYVCAAELLMFSVLAVNVLQAAYALQYPRTPLPPPPSPAKHPKNTPLSPPTRQWRLQGLTPTSSPQRQKAFSTYAPSPVSTPSRTLNYTFRPTSSQPDASFVSSMSSAPGSPASPLAAYRGRHSASVGRAFDGSLLSRLAKDESDDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6D7</accession>
    <name>A0A2G8S6D7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6D7"/>
    <dbReference type="OrthoDB" id="2748248at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="63"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="541" mass="60237" checksum="FBF86D4ED6C91704" modified="2018-01-31" version="1">MDDEETNCTRPAPLPESDLALLHGLTPAEIQAVASHRIREYRSKIEDITNFIHLLSTIHNTAAPIHAKLPPELLIRIFALVSPNRRDHIKLTHVCRLWRQLILKTPEFWEDMILASGQPKRPTDYSWMIKFIQHSMPLTYALNVGPNVPFLHSLESRGHLSRLSELSVRLEDKFALFELTMPNLETLRCAAVGHRFLDLPAPDVDHTVSSASQRFPRLRKLECLHGCLFAPSLAFSSLKVLIHHDRPLEFFLFLKGLELCVNLEELILLNWMPPMHPPTPIPTLNLPCAVPHLRRCHIETNHDGVASWVREFLSRVALPPTAHLLVESESVSRPAWIIPTSPPPSVVQTVDVARVKLLSDASQGAWHHEVHGFAGDSECLTLTMCQSALGAMLTASDCSNPLRGIADLFSSGRLTRLALQCGSGNSVTVDAWLHVLAALPLLADFTVRISSCRHLLRALRRPSAEGEAVLCTGLRRLSISCANGGGVHELLVMAIEWRTSLGLRLEKLEYRNPTSAPLSESRLRRLQAVVPDVVVSADLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S729</accession>
    <name>A0A2G8S729_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S729"/>
    <dbReference type="STRING" id="1077348.A0A2G8S729"/>
    <dbReference type="OrthoDB" id="3218226at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="34"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="315"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="44080" checksum="99DDC495D665136E" modified="2018-01-31" version="1">MVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNALQLIADRHGKIIHLIPCTEEIDAEGTADNFIREWFRLHGLPRKIISDRGPQFSSKLFRAMGNRERWNQEIEAYLRMYCSRHRDDWVKWLPIAEFAFNSHVHSATGYSPFYLMYGFEPQFHIPMLSTAVPSADERREELRQAREDVTSALTLAAERMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVPEVSRKLVDRYAGPYLVKCKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESRRYGRWKKLQYLVHWMGWGPEHDSWEDAADLANAPKVVQKFHSTHPDAPSPLNTKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7K1</accession>
    <name>A0A2G8S7K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7K1"/>
    <dbReference type="OrthoDB" id="2750281at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="370" mass="40183" checksum="18A28ED1AE774A8D" modified="2018-01-31" version="1">MPQISINPQSTLTLLPPPGHPDRFTYMLNLVGCHTAQPPAPEPGALAIQADNVYTAENMVSPWDPNERVDTYVTGDMDLYVGERPRYGHGILFFEEVPHATAQASPPPLAAPATTPENVDVAIGILLFQVPAPPSPPPLIAAMIERHRAEHLADRATPVRETPGESLVLARALVVALTKALVQVLASTMANTPPPYGTAEETPEITYEKATVSMDEEDYEIEDELEYMELQYPSTPRPEVTPAIAGGLAALDDEDLASQGMPEVIDVDALPDELEEDQLVEATTPRYSLRPHAPAPAEVEPYDPFPDRPNLALRGEEAVNLQLLLTRPPSIWTGNDVQAMKAILSSLRRATKSRVGYGQAVQPDAAHHYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7P1</accession>
    <name>A0A2G8S7P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7P1"/>
    <dbReference type="OrthoDB" id="2799385at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="283" mass="31150" checksum="7B63217186A853DA" modified="2018-01-31" version="1">MDDYFLHESQWPDKRARLELARRVNAVLQCSCYSAQHVYMRFVHLRRRQDPAVEKESENSLLTRRCREDAEMSLRVEEATRSDSVVAKLDVLLEEEPGPTPEVAAIWADVLSEGVMAEDIITYALLRQAKRHLAESEMGCKVARAASPARPSSSGSTSTEPRVVERRVPASSRPLTWRTLQTEPSSDPERTRKRRAPPQLTSSSSPSACSQATLSSGDASCLDLKSSSSSSSSVDFPSPAIQGQEVAMLLRHALSAPTGPRPKTFLELSSWLRGSQAVSVTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8D7</accession>
    <name>A0A2G8S8D7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8D7"/>
    <dbReference type="SMR" id="A0A2G8S8D7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8D7"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013641196" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL30033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="640" mass="67883" checksum="244616E49F570401" modified="2018-01-31" version="1">MRPALLSLFLIVVSSRSLGALLQSADDAAAHLASTQYDYIVVGAGAAGGVLANRLTEDGTTKVLLIEAGSSDYNNTNIQIPWLAPVLTHSQFDWNYTTVPQEGMSNRSIAYARGKVLGGSTSINYMIYTRASKDDWDRLASTTGDDGWSWSSILPYAKKLEDFQNSPNVQNATSKFVAGDHGTDGPVGAGLPQVSLAIDQLGLDAQQELSSEFKYNQDVNSGDMIGFSWTPFAIQDGARSNSARDYIQPAFPRSNLDVLVNTQVVKVLQTGVDGGSPIVTGVQITSGPNEKRYNLTATKEVILSAGAIGTPHILLLSGIGPADQLKALGIESMVDLPDVGQNMQDHPLLTTNFQVSSNDTLDNLTLNTTLQAEQLALWTNNRTGDFTLGACNQWAWQRLADDDPIFKNSNVTDPSAGPTSPHFQLIFSDLYIAFGGGAFPNGHFLTLISNLYTPMARGSLTLNTTDPFAYPLINPGLLNDAAGFDIYAMRQALKAGRGFLAADAWKGWIVAEYGASANATSDADIDAYIRKNALVVNHVSGTVAMGKRGDAGRGAGALNPDFSVKGVKGLRVVDASAFPYIPASHTMVPTYILAERASDLIKNSTSSSSSGSGNGAFTQLAAPTLVLVSLALASLISLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8F5</accession>
    <name>A0A2G8S8F5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8F5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8F5"/>
    <dbReference type="OrthoDB" id="2945048at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="305" mass="34937" checksum="A832F5BA6A5515FA" modified="2018-01-31" version="1">MQRTNLLRLFTLNSLRNASFLTRRNTIQSKEYQKKHWRSGHKLLCNAQKVFRDGSVQRSGNPNAWSDLMEWSVFHHSTLVNAALACYIRKKHTVPDITSQYLLQLSLNYLNDPSLPVEKKFELAGTAFTPRDGPFASSLYEHIFEERLVAVELGKIEMGDDLYWGTGAYLLIVRFRPSTVNVCYDGVPFWKHFGIDKIHANARPVCRNPIEQLKENLTEGRKMKFCCGRLEGLPTCCCGGWTHQVSGHGPKSLYLRDSIHHKCPVDYLNENDIIGVVLLLRMHFRDETDVLPPFEDENPSESGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8T0</accession>
    <name>A0A2G8S8T0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8T0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8T0"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="396" mass="43635" checksum="3E65DD06EB15D374" modified="2018-01-31" version="1">MDILEQNVVRATSAAVDELTLSVSTHSSKLSNYQAQAREIEAETATYAKTKTLVKPSVLLIQSGPLPVENAFSLGAMQRVHGLAVEEARAWRQIVKEIVNTYQGVVKVANARGPHIEMYEAAVSTLLRIEMPEDEDRIRATDVASAGIIKDLINRKVGQARPQADVPFRVEAYFLSLDLRSLLAKIAQARVDGFSNTSNDPDTVRHRGLWTSFVIFLYYSCIADAKKAAALAKGCPTPRHGTRAAVYEAQFAFDAFRCKTVCQRAELSRAGALDGAARERLRCKAADYRRGVAQSLQQLEQSHLRAHPSQTADGLREERRWLEENCRAKGVALERECAKLEEELVTPFDIHMDNRPRVAAQTRPEEDFVRQRPSLAGSTSSAAASGPSDKSSCVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8T5</accession>
    <name>A0A2G8S8T5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07668</name>
        <name evidence="2" type="ORF">GSI_07767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8T5"/>
    <dbReference type="OrthoDB" id="2757774at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39257" checksum="D3734F287A414E2B" modified="2018-01-31" version="1">MRPVYLNNGTSIRRFHVFLFADEPARAPHIRALHIDLRQPTPAQNHDEDCSLLVHILASCKHLEHLTIAFHQFTLPIVAEPSFLHTVNAISSLQSLSVRSTSYDGISLLPSFRIPLRSLSIDANNVTYSPRYPANLKEFLPHAVVLTLETLELDRFAVDSPDTQVIGNHLMPLTFTMAPYTAVRSLSVASFRGRPLLDHLQHLFPALEGTLDIGWLNFWTFENRHDDIRTTNQRIQDGDGGRAWRKLDRVVCEAPAFYVLALRCPIRLAMIYCGPVEHYHYVAVALRENPVPRLKLTLYHQPGMFAGLFSTELAGRLTHLTLCVLYSKNYEYSPPGQSKNATPQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8W4</accession>
    <name>A0A2G8S8W4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8W4"/>
    <dbReference type="OrthoDB" id="2753936at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="503" mass="55651" checksum="91F6770C1C694B7E" modified="2018-01-31" version="1">MGQISALANTFCTDKTETLPGLVRSLHLDMCVVLSHCAHVVRHDLHCILTRCDMLLSFTWNPHPHPGFLFDFGPFSAQVPSNYAAFNPNWILNISRIGGPGGAGDLLAWLLHFRLVTLSLDITTDADSLRLLAQVLSSAPHLTSLNLGTVLLQSSGLRIDPWSTLPYLSFPELRSLSIYCDVLPFVQYVATQWTMPRLASLHSKSGLPIAILTAHGQYLTYLHIHSDWSPLYLSANAALPCLHELCPRLTHLVIRLAPRDCPTLNINSPTLLYLDLLAAASVAAYRAIALAPTARAPRLRKVRMIMTLPTCDFLPLHFHPTHLPGSDSALEDLSSIPGADESDDATDWLMLTTGGIEGWCPEGLVRQLSWAVIVDECRKGTSPPEAVWDSRIADSDDETDSDGVYEYESRPTSPMSEDTDMDDSEDGDGAEGRDGECEMGDARSEDGMGSDSDMEREWFELEPEMPNEVRFVDDPLDSSRGQYDRETILERFSQSQLGDFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S990</accession>
    <name>A0A2G8S990_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_07505</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S990"/>
    <dbReference type="STRING" id="1077348.A0A2G8S990"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836163" description="laccase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="29"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="159"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="365"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL30321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="514" mass="56160" checksum="293DEF5FC52F25A9" modified="2018-01-31" version="1">MLQNVAVLLGAASGVLAAIGPVTDLTIANKVIAPDGVPRDTVLAGGTFPGPLIQGRKGDRFRINVVDQLQNETMLTATSVHWHGLFQHSTNWADGTAFVTQCPITKDHSFQYDFRVPDQAGTFWYHSHLATQYCDGLRGPMVVYDPHDPHAHLYDVDNEDTVITLADWYHLAAAVVQGERPPSPNSVLINGLGRWLGNPTSELAVINVEHGKRYRFRVISMSCDPFFTFSIDNHALTIIEADGENTQPHSVDSLAIFSAQRYSLVVTANQTIGNYWIRANPNNNEATGFANGINSAILRYKGAPEQEPSSTQTSNLRTLVETDLQPLTNPAAPGKPYSGGVDYALHLTLGFNAPNFTINGHTFNPPSVPVLLQILSGKQSAQSLLPAGSVYTLPPYSTIELSFNASNVVGDPHPFHLHGHTFSVVRSANSSEYNYKNPVRRDVVSTGAGNDNVTIRFVTDNPGPWLLHCHIDWHLQAGLAVVFAEDTKDTAFTNPLPESWKDLCPTYNQSLHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9B5</accession>
    <name>A0A2G8S9B5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9B5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9B5"/>
    <dbReference type="OrthoDB" id="3207336at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="259" mass="28367" checksum="98AEF98A100C08E6" modified="2018-01-31" version="1">MWPGDRDFLCATLWFLTGAIATALDVYKLAGFNIYILQRCPVQYLCWAWLYAPTNFRFLDGISHPPVKDFDTKPIPGQETVTQGVILCERENNVDACTSKLFVRPAWAFRGSFSIIPYLSQFVPHFNNFLKPSECPLHVLTAGLMGARLMGRWKGGPSSVTAILVQRFLIHLQLANRKALHVGTSQNAGSSQDSMGTLVFERVVGSLSASLTPDDYVSSTDVDSAMFSKSSDASDAGEGDVDDGRGKESIPLARVGPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9N5</accession>
    <name>A0A2G8S9N5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylserine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9N5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9N5"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF13">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48878" checksum="F001F2078E1CD4C1" modified="2018-01-31" version="1">MSYTPTTAIVQELVDYFSENPEFKNAFDQSFLMAYATGLREFDTFNIHSVDDYLRYMDEYVHWVPSENLTGTNVYNHICIFYFILDLPPVRDHQSPIDPSSRSPWRWLSEWLIKYAKEMGMWMDSPGSITPETIETFVKSPAYRDTPETDFFDQYPPPPGGWQTFNEFFARHINPTFRPIAALDDPTAIVSPADCSFDGTWAVNDDPANVTTFDVKGVPWSISQLLDDEASGTYFGPLFSGGTFTHSFLNTTDYHRQHAPVAGRVIEAKVIPGLCYLEVVLKMSEPVGKTPNSSQPRLGMHRQILPKAADPTVIPHQAVIRANKKAKAVPASTTDELVPDAPDSPGYQFIQARGMILIESEIGLVAVLPIGMAQVSSVVLSVKKGDWVEKGQEISCFQLGGSDIVMVFQKDAKVQLDQEKGVHYKFGTKVGSGQRVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAT6</accession>
    <name>A0A2G8SAT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAT6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAT6"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="809"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1220" mass="129122" checksum="856E42B788960427" modified="2018-01-31" version="1">MHFGPEWMRTKGSSRPAPSPPLTSSPAPPGSSTYSALVTPASNPPPEGRDVAHPFRYSKEEMLRIYKEGGGRGGLGLEVERWEGIVREVGYDPVGLKDMGDAEKKLFAGPLNSEVRRRQSTDFLSPLNTSGLGERPKLNHATSAAGSPMRERIGSFMGRRRGDSTGDGYAVCLESRCRLTRRGLQDQAPLALPRKLSISNMQGGLASPREGALPSPRVRPGFDGVLSDTWSARRRTSENVPKGGGKGDKETDGETKDLDIKEEEEDAIRASEQAKEPAGGTSGGVNGEGTSNGVEQVNGQLGNVSISGQDGQPAQNQPPPGLADLSTIDWSYLDPQGQIQGPFKADLMQRWYNEGYFQANLLMKRTHLDTDWTPVGELVRRVGEGQPVFLSPLVHNPTPPGLPRPAENVVDRAVPERNQHSPYQPVPMRSVRSATLDSYLQNSSSASDSPSSSFGGRFANGSPDPAVFDNRQGAQFAFDQPEQSRMPFATPSAGAMGTPQRRATQNETVDPMLGTRYAVGRNSGTDGLGFGGPEGPGIFNDGASPFAQRIVPDSGALNGLGGSSALNGGAEFGPIGGIHSSQGTPSRVLNRDPFGRPAQEELQQGAALGGSFSNHSSPFIPHAQAAFPQTPLSQFAGQDNRSLHSMTPERPQIPFIQQLQQPFAQSPSFVNSQSPWHTQEAPAFRRPGPFDANHPTSSNTFISQPAAPSQPFGRVPQGSIQTDQSPWQTPIQPVQNDPWGTQTASLTAANLGQHDEQQRQAELRQQVVKPPPQQVPPEPEPAPVPVEEPQPQPSLPAAVEPIFVTIPSPVDVAPQKPRRKSTAQIAPAAPPAPKVAPPAPAPAAVSVAPLKAPSPISQAETKAAWAVEDDKKKGSAPTLREIQEAEAKKAEARKAEQRERERAERAVRTSSQSEDFQSFTTSWGLPTSQAGTRSNSNGPKEAPVVVSPFNAPVPVAPSPAVWTNAAKSPVAKKTMKEIQEEEERKRKLAKEKESMAAAARRGYADTTTKPSGPTPPTGGAWTTVGANGKSTAATIAATAVVAARPGVTPTASAKVVPTASAVPASSGNTSRPSTAVAAARPAAVAVKSASSKDESPAAPGPSLEFLKWLGDSLKGLNNSVNLEELTSMLLSFPLDPDPSTVEIISDLVYASSTTLDGRRFASEFVSKRKADAVSRPKGASASGTAKAVSIADVVKTQPKPAQNEWGGFKVVNKKKKGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBC4</accession>
    <name>A0A2G8SBC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBC4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBC4"/>
    <dbReference type="OrthoDB" id="2743553at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="13"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="303"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="437" mass="48654" checksum="B067C79087695DF3" modified="2018-01-31" version="1">MDKELDAFLTFLDNSQLAVDIFRTISHQIANQHTLPIVDMPHFRISGFDVVLNSLLDASLLTSVTASGLSLWVKQWLREYLFDSEPALGPRTRALVRLYRHHGLRTWKVAAIVASISILLQLSVLLFSVGVVMLAYKLDVALARVLLALNVLWWAATWATALAPTFFPSSPYKSPFARMIFALAYYVRRIGGSLSRLLGACRRDRTSPGSRTSGRAGTLPFRTLEERELDVISNDSDSNSDRRSRLELEALTFANVVFRGSERLAAINACFREVEGKEEALDCIARILREQYGVDEEDSYDQWTHVADALCKHYKDHEKAIHEELDGFLSFSGIFSAVVTLFVGQSVTWLQPDNSQVSVDILRTISKQIANQTTTPIADSDVQPSNTPSRSFTVTDMLSNGFANTFLTSRLPLTIALSFNYTGTVPYKGGKSTKSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBE0</accession>
    <name>A0A2G8SBE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_05748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBE0"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="7">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="8">
        <location>
            <begin position="650"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="822" mass="88926" checksum="EC02D24A2B53D872" modified="2018-01-31" version="1">MIIALVVSLAIHSWIEGGVIAGVILLNVAVGFMQQYTAEQTMYGLPPPPSSATPAQPSPSSPPPSSSRATSSSSSLATSSPPSPELRLLDATNLEADESLLTGESLPVPKHAHARAPTQYPPVPQVPVGDRLNGMAHASSTVTKGRAQGVVVATGMRTEIGRGGWLFVVAAANRFVDDREVVIYAVSTGLCMIPASLIVVLTITFAISMKRMAARRVVVRKLDSVEALGAVSDVCSDKTGTLTQGRMVARVVWVPSVGTWTLEDSRDPFNTHDGKLVFSDSHVRPRVSKVNDGRGGGWGGGGCASEKELDGLLECAALCNIASVFEEHAAPDNDKPHGTDKDKAWAARGDPTEIVLQVLAHRFSRGRPALVAQGYEQLAEYARVRIRTPGEPEGDRALEAGDRDEIVGRVDGMAESGLRVLALAGREWEWEGCRGAENVERGEVERDMVFFGLVGIYDPPRPESRLAVEDCRRAGIVVHMLTGDHPSTATAIAKEIGIVEDKDVACMPKHTVATASEFDGLSDGEVDKMEELPRVIGRCSPETKVRMIEALHRRKRFAAMTGDGMNDSSSLSRADVGIGMGSGSDVAKNASDIVLTDDNFASIIAVIREGRRSFDNIKSFALHLLAGNVGQAIVLMVGLAFKDQEDLSVFPLSPVEVLWIVVVTSGPPAMGLGMQDAAANVMRRPPHDARRGIMTSLWICHQRDFPLVLRSRGLGIRRRRLGAGGCNNSREDCEIVFRARATCFATTSWLCLLLAWEMLDMRRSVFWMHDGAKNPWMQWTKDLWANQLQVLFWSVVLGFVGTLVVTYLPVINDKVFLHAPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBH0</accession>
    <name>A0A2G8SBH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBH0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBH0"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="536"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="743" mass="82415" checksum="CE2D04DD45684EFF" modified="2018-01-31" version="1">MQAIQQSLSSLLTSLPPSPQDNASLNTLVKQTLSKAQSGANPESWKNQWEFALRNSIFDLAATEGKALKDPKTTYYDQLSCILDITLAFTENDACDQVFPFTILQDLLETQTISSCSHIFSWIEERAERLTEGLIPQKGKALVLLRTLNDLLRRLSNTGATTMFCGRILTFLSRVFPLGERSGVNLRGEYGPTWDGPGTKPEVVDEPEKDKMEVDETKEEQAASAAEKRKKEKEEFYQTFWWMQLPFSRPPLFAEPTTFPAFKEAVNRVLPLIKEATAKDRALMGSKVNGIPTAPSGPLKRKREATAPEGTAKSEYYFAKYLTSPELLDLEVADTHFRRQFLFQLLILLNHLLTFTKTAKAAWATTRNRSLQIDFTLEPDDMQWVQETITRTTEELRQTAPNGRAFSETVQVILEREKNWIRWKNELCTPFDRESWKEEAEVGGERRKVGLEEATEGERKKMRVDQEAWPHRYGSAPLTEIWEMGYRDLWDLQHPFHAGDVKDFVKKIKQEDARIEMRKKQLMKQAERIAAARAKAAQATAAPKDGAGARAASTPPIPATPAMSASGSQDSLPPSKSTNSQSALASAPLHPSLPAKPGTTPGPEGAVPSPVRVATPNPPPAAPSPTPTPAVASPAPAAPEPAPIQLPPDEQIKKYEENKQRCAWLALRTARDQYLQHFGKIGTGDIIMLQQEIENAKVEKEKAAAAEAANAVTATASPAPPPPTEDSKGAQKDSEGDVKMEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBL7</accession>
    <name>A0A2G8SBL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBL7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBL7"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="71"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118891" checksum="0F6ABD6E583A3830" modified="2018-01-31" version="1">MVFGILEDHKLDNVPGTGLLSDRGRVCAGTTDGAADLKRGTGRYSDIILIPQPSDDPRDPLNWPRWKKEACFWTLVFATSLVGALFPIATSGYVLLSKEFGVSVDNVASSFSSYLPALAVSLLLQNTLAVKYGHRIVYLSSTLLMFIACCWTALSPDLVSIRVSRVFQGFGMAASQALVPTTMEQIYFVHERGSRSTIWNFATLAAETLSPFIYGYVIQNLSWQLGFWFVSIAFGLLFVMTLFFVPETTFPPSSSKSPQGERAGTTVIKEIHQPNEVLEKHVDRASVLPAKPPPFLSQLRIYNGTFSDENLWKIFMRPFPLVLSPVTWFIFWSFMMQAFWFSLLSLCASTIFTISYHFNPAQIGLTHLGGLIGVILGMLVTGPLSDWAIVWMSQRNRGVYEPEYRLVFMLSTLVGMFGYIGWAIGSDNSMPWIGAVSCFAMVTFGLVVSGGAAVTYLLDTHGANALHILSITDFAKNLILYGVAFVANSVVAARGVKVALLILGACQALCLLASVPMYVYGKRVRSFASRMARSKPDKGRPRLNFDTLCLICNSITDVSDVLSFALTCSALKTDALQRRLQMSPVTLSSPEVVDKFYNFIMDDAAARAPHIYGLRLPRLKLTNATKKTTADRLVAILQCALHLKYLSLSTAGLEGPLLPAVVKLSTLQELVLYAGYHKSHYTKLLTSLRAPLRHLHIKEILQREMTASFVHNTLSHFAPTLDSLELADFTLDMSPSSVTNPFSALRSLKSEVIRDFDDLALLLRLFPNLDHALVIEYLRPRSTDYSTIRQRSKEAQKVHAWRGLDHVVMGDAMQAFLFALQCPIRVMDLDHRITRSEVKEYLVDVLRHNSPRQLRIILDVSGCDVAGLFPVEAADRLTHLFLCLSFQLECRRDYEGRRDRQPWHQFLETLVNSVKHLRLTHLRILLLYNVLRERGPPPGDVDPDVVYFARGEDLHDAGMSFFGTMPTLQYIFLTTGGYTILSNRAIVHRTPYESRWLTSKAWRITDANACESGRDLCPSSTELGTYLAREISNDEAEAIATQEEMQLPGRGRERNLVTHCGSCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBQ6</accession>
    <name>A0A2G8SBQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBQ6"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="187" mass="21029" checksum="ABD4DC037281460D" modified="2018-01-31" version="1">MEPDGHPELPLFVTSTDARTPKVAQARSNPRVEVAWWMEGTRDQFRISGFVHIVPAPAKSKDGSTPIPAEATTLKSLEESGFDFEAKRKETFDAMSTVMRATWCVPVAPGTRIESYEEQKAWPSEVPLERDAKTDEERMNIEVSFSNFALMLVEPVQVDWVSLGVLPYSRVSFTRDGGNWIEQQLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBW3</accession>
    <name>A0A2G8SBW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBW3"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="8">
        <location>
            <begin position="364"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="9">
        <location>
            <begin position="795"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1026" mass="112406" checksum="A0438C70382BEFF3" modified="2018-01-31" version="1">MALNMALYTRSYKDPEMARRKVTRNDLTFLRSLLRWLLFTMLSTFLGGVLLMGRSVRDHMSFLTTSLSDVVFGEGDTFSGNVSTCPGYTLSAVHETPTGLTAELNLAGPACYAFGHDIANLTLEVTYDTSSRLHVNIYDTAKAQFTIPTSAVELASGPSDPSAKHSSDLVFNYESSPFAFWITRRSESDAQPLFDTRISSLPATPIPPTNASDSSTGFDGFPLVFEDQYLQLTSALPLDTNIYGIGEVVAASGFRRDMGTNGSPGTLQTMWARDAADPIDENIYGSHPIYMEHRFNTTTNKAQSHGVFLFNAAGSDTLLQTPASSPVSLIQYRLLGGTLDLYFFSGPSPQSVVEQYGELIGLPTWQPLWGFGFHLCRWGYTTVNETRDQVVAMREAGIPLETMWNDIDLYHAFRDFTTDPVSFPIAEVKAFIEELAANNQHYIPIVDAGIAHQTNDTDFYDPFLRGTEEDIWLKNPDGSVYIGQVWPGYTVFADWFANNTEAVWTEAFKNWSDSGVEFSGIWLDMNEVSSFCTGSCGTGADLSDTTTPFILPGAPGNPVSEFPEGYNATIWGRSGNMTINGTSTFRHDGTTEDILVSRGLGAGQEGNVNVDNPPYAIHNGFGLNDLGERTIATNATHANGLVEIDTHNMWGLMEEKATHLALLAIHPGKRPFIISRSTFASSGKWTGHWLGDNFSKWSYLHYNIQGVLQFQLFQIPMVGADTCGFNDNTDEELCNRWMQMSAFVPFYRNHNEIGAISQEPYRWESVANASKTAIAVRYSMLPYWYTLFANASTRGTPPVRALFFEFPDEPELFGIDTQFLIGRDILVTPVLEPNVSSVAGIFPGRGATVWRDWYTHEAVKVPATPGETVTLDAPLGHINVHVRDGAAILLYAQPGYTTTETRQGPYALLVTLDGEGRASGTAYVDDGDSVPPTPHTTLGFSAEGGRLAISSQGDFRVEQKLASVTILGVGSGRPRAVSVTAGADTETETDSESLQEGDWEFDAGLERLVLKNLAVDLNGAAVVSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBW4</accession>
    <name>A0A2G8SBW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBW4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="55546" checksum="C689DDC5A282B4C9" modified="2018-01-31" version="1">MSPITLVDNESVLSLHAFIFSDEPSRARYIYGLRIPGPYIYENQVADRSVFDNSLVALFAAAVHIQYLHFPTSIKGPVFDAVMKLTTLRELHAVSEDTRRPLLMRLPTFQSPLRSLCIEECDTMGDNISALFLHEHLSHLAPTLEELDLDFFQFNIAPSSITTPFLALTSLAFATDYITFEFHPTAILLCLFPNLRGTLVIVPMRIVFIHDYLSALREHSVEEQRARAWPGLDRLVCDAEWAFVLALQCPIRRMDIHIARSDGKGCLADTLRSNAPRHLHLTVGLKAHEVWDVLDGLFPAEAADRLTHLVILVEFEVYSKWRSHLKGKRVPWNRLFNKVVDSVGHLRPTHLRIVLECTVLQGVPNSFPDGQLVNAAYEVSEPDLLCVAARLMDTMPTLECLFLDAHGETYTVPVRNDWEVDEDQTPHVWHLSKGWRFVHRDPDEVPVGDISSPGPWTELAGEAVERVAEEAELRLARFREIRQWRNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC36</accession>
    <name>A0A2G8SC36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC36"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC36"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836165" description="RlpA-like protein double-psi beta-barrel domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13826" checksum="D2B40C6F78BAE3A4" modified="2018-01-31" version="1">MAPFTYFAFALALVSSTLAAPTVVSLEGLDKRAADHTGRGTFFEVGLGACGKVNKDSDHIVAIPSSLFDGGKHCKQTVLIKNKKNGKTAVADVRDSCPGCGPNDLDMSPSLFKSLSASLNDGVIPVTWHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC77</accession>
    <name>A0A2G8SC77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC77"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC77"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="212" mass="23388" checksum="039CB41E7D30FA37" modified="2018-01-31" version="1">MIRPRTGDFFYSGAELEIMKEDIRMFRDAGADGIVFGFLHKDGRIDVERTRMLAEEAGSMQICFHRAFDMSSQDVLTAHLDVSTVPQVTRILTSGQSPTTASTGALPQLRTLVRTAAHMPASATILVGSGVNARTIGPLLEELLPHGLREVHLSGGAWVASEMEFRRPGMGMGVGGDGEWGVWRTSEERVREVRTLADVAWTEFREKSKDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD14</accession>
    <name>A0A2G8SD14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD14"/>
    <dbReference type="OrthoDB" id="2637024at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="15816" checksum="CA013D2002C7BCA5" modified="2018-01-31" version="1">MASSSPLPFDPSRLPSYRSSHVGRFHPYPRGGPRRGQDALMQTVDYRTADRTPGLDTIPEEPEPVHLSPLAHQEIPDGDVSFFELDHPVVGDASYFDRGVRVENAGEKTRLTAITHILTALRRRSLALLASMNVLKSGRWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDU7</accession>
    <name>A0A2G8SDU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDU7"/>
    <dbReference type="OrthoDB" id="3226250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="574" mass="65819" checksum="B12E403FC4B6C982" modified="2018-01-31" version="1">MSNFRPSFPLEDLLDEPFGPFTEASALSPRVHSSTLKNPLVLHSVSLEAGPGVITGLDECEQCQPGHDRKRFRNNLQVLFTGILDVDNPAWLTTQAIHTIQKELRKRDHIARLAIDPRARHRDNSFDFLHQALANGSKTVKLIIQAIKSQPASFMQSKQVPNGLLLISSFKHQSNPERPTSTNYRRYKVPSLHIATYERSRRYLRRWRLFWELQELLALDAGPGKSFRDNKTPLAERTPEWFVELYMRHKAYADEQRSYRIHYDSGSDSDIQPGSGGSLKPGRQHVPRDVSRAEIRFRLERDGEWVAGQANANQQSRWLNKGVWAEWLADLGSKRTMRQRIRQSDVSEIGYVSLGDDAKARYFAPNPSRSAPRPRVVKKRASKRIVMSRPSSPAVTSDDGVDVDETMMRTYDPDFSPASTTLGSPISSPSRPSTPVDPNLLALLPAESWHPPNVNSQLMWTCPWNDCLHTIDLLHPTDDDMDHPAISDDDKRRFRNQLASWDGGDVWARDAFAYMADKHHFWHLDQAGIDVEVIDGRYLFRWRHPSSHHRFPELRRVKTDNREPKAEEIKQEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDY5</accession>
    <name>A0A2G8SDY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDY5"/>
    <dbReference type="OrthoDB" id="2497682at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="258" mass="27139" checksum="D75E45790F2A9586" modified="2018-01-31" version="1">MPTLSRAVFLGFQAAAFLATVGPVLVPLSTLATPVLLPMPMPMPLMPDIADYVSRTPLKTSPNVVPVSLGDSTLLGQPGTDSAVVEGTPPAVSSGVRRRADPLETLAACVHILVNLSTSGNDTATQQQAVVAAAAIVDTLRTFQGLLGDQQKGLANFDPNNPLEVMLKTLINATKDALKAIDILVYRMPFLGPLLGPVVYEVKCILDAILDLIENITDGVINVLLPDLRADLRVVIEVAVTVTCNTGSSPQDLCVIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFX3</accession>
    <name>A0A2G8SFX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFX3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="187" mass="20601" checksum="0C3972E885058F43" modified="2018-01-31" version="1">MAGRGIVPRRRRLGAMAERGNHEVGREHGGLPSRHGALRGVQCRVCELERDRSSLRRKHRAWRGGSQAGGRPEEIEGPGLARRTKCVFGALLQELERARLLTSERRPISVPVPGGGKKDGVERGHGRVREVHKLAQFLCCECGLERASTADDGDVLDSRVAEDGKYRGRDVVVGEMRGRSEQHACDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGH2</accession>
    <name>A0A2G8SGH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGH2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="15150" checksum="3FE0C2F250EDDEB7" modified="2018-01-31" version="1">MQSSCVLFIVFHSLPPHIFPPPSQSPSSISHCPPSGKSLQQSVRGQPVPSSLPILHPHLKFRRKRVRVELAIGYSVSSVPLHAYTTFCLFTVLALPIHPMYIQPLFQANILTYAPHLIFVYNRSSMSSPKGSHKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGK7</accession>
    <name>A0A2G8SGK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGK7"/>
    <dbReference type="OrthoDB" id="2751407at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="133" mass="14392" checksum="A2E89A54FF2FD8E0" modified="2018-01-31" version="1">MVRDVLGDTRPTNLTMSIVGAHLFEDNAFVAALAYPGVEDLRTLEIEVCLDADEGAVDAQTMLYNIARTLSVLPLRGLTLTLNYGLFADETGGQMHPIRRTLEGLDLEAAAGIFRSLIPSVMDVVVGLSTDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGT9</accession>
    <name>A0A2G8SGT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitroreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05108</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGT9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGT9"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="255" mass="28058" checksum="51C451825C62BCA6" modified="2018-01-31" version="1">MVRALSSIASVYNRTSRALLALTHRRPASPLHTPQLSASPLAPTTTQFRTTMSGSAAFFEAVKGRRTIYALSSESTIPDEKIQEIVSEAVKHAPSSFNSQSSRAVLLLGDEHKKLWDITLNVLKGIVPEDQFPATEGRIKGFAAGHGTVLFFEDENAVKDLQSKFALYADRFPQWSQHASGILQYIVWTALETEGLGASLQHYNPLITSQVQSTWDLPESWTLVAQLVFGKPVAPAGDKTFEPIEGVRFKTFGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHJ0</accession>
    <name>A0A2G8SHJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHJ0"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039646">
        <property type="entry name" value="ZNHIT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 2 PROTEIN FON -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15555:SF0">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="25706" checksum="F3C466122BBF8870" modified="2018-01-31" version="1">MVEEKVEELVIVSSPRETESVSTTPCAILHGMRAHDATYRIARSSVSAPRVVLPKEVELDVKNSPSASLEEKRRMMELLKQFEEDSLDDSPLLDDSDNDNEGEQAADDLQTRMQNLDLDTASSDKLWAALTPTERERFLCAVNDPHSELAQQLLASEQLEKAQVEPWWEPEFPSPVDERPSPLGMPASPTSTRRNPSHKPSIMSIPESLTRQAATSAVSGPLLLYNICALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI56</accession>
    <name>A0A2G8SI56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_04698</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI56"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI56"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF10">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013661398" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="18"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="203"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="517"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL33248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="557" mass="57694" checksum="50795B9FC76271B8" modified="2018-01-31" version="1">MVASGLILASLVTFALGKPAARNLKPHESLDGAPSGFSHTGSADPNQTLKLRLALVQGNVAELERQLYDVSTPSSSNYGKHLSKSEVQQLVAPAQGSVDAVNAWLKENGISAKTISAAGDWLSFEIPVSKANELFDADFSVFKHDDTGVEAVRTLSYSIPAELQGHLDLVHPTVTFPNPNGHLPVFKTPVKSKRQVDASCSSTITPACLQSLYNIPSDAATQSSNQLAVTGFIDQYANQGDLASFLQQYRPDMSSGTTFSLQTIDSGSNPQDSNAGVEANLDIQYTVGLATSVPTVFISVGNSNQDGDLGGFLDVINFVLGEDSVPNVMTTSYGQDESSISQKLAQNLCNAYAQLGARGVSILFASGDGGVSGSQSNSCSNFVPTFPSGCPYLTSVGATQGVPETAADFSSGGFSNYWGVPDYQSSAVNGYLSALGSTNQGMYNASGRGFPDVATQGVNFEVVVDGNVSGVSGTSAASPTFAAVISLINDKLIAAGKSPLGFLNPFLYSTGASALNDITSGSNPGCNTNGFSAEQGWDPVTGLGTPDFQKLASAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIC6</accession>
    <name>A0A2G8SIC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSI_04134</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIC6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIC6"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="22">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="23">
        <location>
            <begin position="112"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PIL33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="57200" checksum="5997AC44B8792F34" modified="2018-01-31" version="1">MSKVMISGKEVATHNTRESCWIIVHGKVYDVTDFLDDHPGGSRIILKYAGKDATAEYDPIHPPDAITTHLPPEKHNPRAFSLGSVDPGTVQKVEVEVTDAEKQRLERVANRPSLSEILNLHDFEAIARMVMPEKAWAYYSSAAEDEITNRENHVAYHRIWWRPRILRDVTHVDWSTKILGHASKMPLYITATALGKLGHPDGELNLTKAAAKHGIIQMIPTLASCAFDELVDAAQPGQVQFLQLYVNQDREITKKFVQHAEKRGIKALFITVDAPQLGRREKDMRQKFEAEDPAEVTANKQEGKVDRMQGAARAISSFIDPSLDWKDIPWFQSITKMPLILKGVQCWEDALQAYDAGLAGVVLSNHGGRQLDFSRSGVEVLAEVVREVGARRSLSFPNDKFQLFVDGGVRRANDVLKAVALGATAVGVGRPFLYAFSSYGFEGVDHALNILTDEFEMNMRLIGARSLKEIVPEMVDASSLKSHIVPVPGDRLFDSNYESMQHARLREVKSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ27</accession>
    <name>A0A2G8SJ27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ27"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ27"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="193" mass="21974" checksum="53A86F86ABD39622" modified="2018-01-31" version="1">MPSLICVICMEGLETKAAMSTTCGHIFCSQCAESQFAISQSCPVCRTPQTFRQLIRLFSEFDTPATDPPPSAVPASTFPPNPEGPYLEPEIISFRWHTQQLQSRRLLTGYHPQQPHRQMLQVQIQPSVRPSRRSVAYFGMLQPRPRPSTLDDMYPLLQSLQELRHAQRPPDHASALLTLQHRSVQLRLSQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJI1</accession>
    <name>A0A2G8SJI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJI1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJI1"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="140" mass="15890" checksum="2ACDE37BB7061643" modified="2018-01-31" version="1">MHVLARLKSTLTACTPFCLTSKHILNAQVAIRAPCCKQWFDCAECHAEAETHRLTKTTEMVFMCKKCKKAFRKNMAEYDESDEYCPHCDNHYVIEAKTPQAAIGVEGDDPRIDARMLKDDRIKGDTSRSLFSLDTSDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK67</accession>
    <name>A0A2G8SK67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="1">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03875</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK67"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK67"/>
    <dbReference type="OrthoDB" id="3366231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF95">
        <property type="entry name" value="HELITRON HELICASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA helicase Pif1-like DEAD-box helicase" evidence="2">
        <location>
            <begin position="179"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="632" mass="70231" checksum="F5D597F875944F3F" modified="2018-01-31" version="1">MAAESGLRHSFLSQTPHIARKPGAFHYATAAASLLERPRAKAPANIAGPSRQGALLLSDGHKAEHALTEAIQSLKSPNQLRSFFVHLLVNDHVASPITMWNTFQDALAHDLILRHDNVNFGVNETLQEINRALEEHGRSLTHYGLPQPAFHSREVEMELDKWEGQLDVLAARSATAVSKLNKEQYGIYKEIMDAVTHKRSLCAFVDGKAGRGKTFLVNTICNKLRSEGHIVLPTATSAFAAQLYPGGKTTHSVFKVPITADENEELVSPIEPHDPRGELIRESSAIIWDEAPMAKSEVLTCVEETCRRVMRNNLPFGGKVVVLLGDFRQTCPVIRQGTRRQVVDASIRSSPLWREFTTFRLQQPIRNAEDLPYADFVDLIGDGAGPYIPLDLLQHVHNRTSLIEFVYPEDVLRDPALCLTRAILAPTNSQVDAYNTEILSKIEGFTRTFYAADAMQDPEEVDDTSPDLLLEQAERDCIPGIPAHNLEVKVHGVYRLMCNFAPDRGLVKNTRVVVMHIGKRIITVRILRGAGGVGSMDTEDVLISRIPFTAMLPSGHTLVRRQFPLAPAYATTFNSCQGLTLDVVGVDLTRPVFSHGQLYTALSRIRHRSHAKIRLHPGQTKTKNVTYHEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKT9</accession>
    <name>A0A2G8SKT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_03156</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKT9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKT9"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013822643" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="21"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="244"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="244"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL34381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="366" mass="38227" checksum="8EA9E1152235A9FA" modified="2018-01-31" version="1">MFLYYILTLFLVALATQVAAHGYLSEVSIDGQTYVGNVPNQTPKDSPIRLIDDIDPVKGASNPNLSCGQNAQNAALVVPANPGSQVAFSWASGNGGNWPHNTGPLMTYMALCEGTTCDKYDATNANWFKIDEAGLKPDGSGWWQQDIMNGQSYTLTLPDDIAPGEYLIRHEIIALQIALSVGGAEFYPSCTQVRVGGSGSGTPSPTVHFPGAYSDTDPGIYTPDVYNPGFTYVFPGPAIASFGTGTGNSSSGTTPTGSSPSSSPAPSAPTSTSSIDPPSSSSNPISSTASTADGGDPTTTFLPSSTMSSGSTSVSSATTTSASDAASSTSSSSSCWDQNGKKHLHNWARDWLETRRVIKIRRSRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SML6</accession>
    <name>A0A2G8SML6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SML6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="85" mass="8770" checksum="557463DEF90AD16D" modified="2018-01-31" version="1">MGMTMLPQSSMRGGGVEEPTLNDSSVDKFSTSSAVSPGRVSREASIRGRGDKDDDLEAFSVEDVLPSTASCVGGTIGNGVWPFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNI5</accession>
    <name>A0A2G8SNI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02047</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNI5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNI5"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013721943" description="chitinase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL35322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="363" mass="38793" checksum="6096C25D84B90D99" modified="2018-01-31" version="1">MRSFLALAHLLALGSLPRVMAAFDMNKNNNLAVYWGQDGANGQQPLSHYCQDDTIDTIPLAFLYQFSAKGGMPAIDFANTCSSSGDSVFKGTALAKCDDIGADIKTCQQAGKIITLSLGGATGVVGFASDAEAESFADTIWNLFLGGDSDVRPFGDAVLDGVDLDIESGSPAHYAAFVNRIRANAGEDTTSDAAKAKTRRSLSRMVKRKAKHGPSPSPSKNSTTTDPTGKNKKYYITAAPQCPYPDANIGAALNDAHFDAVYVQFYNNYCGLNYKSEFNFATWDKWAKTQSANPDVKVYIGAPASPDAAGEGYVSPSTLAKYVADAQKKYDSFGGVMLWDADTAYNNNRFDKAAKNALMASSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNS7</accession>
    <name>A0A2G8SNS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNS7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNS7"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF5">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="576" mass="61900" checksum="6F4FB22B82740571" modified="2018-01-31" version="1">MSNKSPSPRPEAVVAPAVDIEHVEVADDPRQWSKMRKLTVVATVSAAAVIAGFGGTLYNPALAQIQEQLHASNGEIAWSLSLFILLQGAVPLVWSVLSEFWGRKKVYLLSTALAVVGCIVAALSKSINVLIGMRCIQALGSSAVMALGAATLADIYEPHERGTMMGIYYSAPLLGPSLGPILGGVLTQAFNWRATFWFIAAFVGACFLLFIPFKDTYRRQRSLTYQAALKRRRAIMSAKGSETSSITQVAAISRAVTPGPEKEGASGPFPPSADADAEKDAIATLARDRDLEKQQLPARTPLTGVDDDEDDVKLTLADVNPVKPIMYVLRRMNNLTILVASGLIFGLSYCIAYTCSRTLANQYGYDALQTGLVLLSFGVGCLSGSVFGGRYSDYVFKKLKAKNGGTHAAEVFFPDPSLDAGSIDHWSEIRTQMRLESTIIFMPFLPAATIGYGWVCERHVHVAAICVLLFFTGLFLIAIYSSTLAYIVDANTGRSSSAVATNSCFRGLTAFIAAEVAVPLQDAIGDGGLYSLWAGLMVLAEVLILLVLWKGGAWREKWERKEGGITHAGPSGPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP49</accession>
    <name>A0A2G8SP49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP49"/>
    <dbReference type="OrthoDB" id="2758509at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="502" mass="56688" checksum="E435019650A29F2B" modified="2018-01-31" version="1">MSALSDPLLRDPVFPMFSPDVGHRIVFLMDFPALMKFRALCRASFDVVDSILQKEFYSILAEKVPKPAAFHDALDEHDVYVGSFSALAFFLRQRFHIDTDLELFVPRAAFDLMRQHLLEVQRAVCVSDKPVGTITRGVIRVSEWRTPSGSITLYRSMVNDALYPILRGTSTAMMVYANPVRFGVIWPKLTFNLRMMPGPLSDAPESYMPIFRMIGFTIHLYPWMWNDMGLFQTCAADRFLCPAQPRYIHDAGSFRGTWHPGSVDPLIVAIVAVPSSGFQPLVASYSYHSLLTPIIFMSDSLKTEADADDTIVVDKWVTNKQVRKFRRFLTWVYAPKIRYSLSMLPSSADWGTRAYDVRFLCYRGEPVTICVVGAIHGYTLSCEKGSPSRVEVTLDLLRNGDRDVMVRLLDKSQPPPRVVPELCKITLKQDSGKKKGFDAVYNAIDGFSTTYSMPEFQFSALKSGDIVMAETLLRRDLEVDGTWDVGFELSTLSVLALSPRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPY1</accession>
    <name>A0A2G8SPY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RPA43 OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01491</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPY1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPY1"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPA43 OB" evidence="6">
        <location>
            <begin position="139"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="369" mass="39842" checksum="7A92D84853AA5A20" modified="2018-01-31" version="1">MSPPAEAHKSKKRKHAAAAEGAGAAEPSTKRSKKDKDGAKDAKRKKGAKEDKGKGRATDDAFRVVRASLTVSVPPAFAADLRGGVEELLDSMLVRYIPALQGVVLVHDRLEFLDNVATIKADCPSSNCRVAFDATVWSPQVGMKLSGKINLCSPDHISLLVHRTFNVSIPRHHITTDSYEFEYGPAENDPEFGGAQDEGADGERAQEDMEHGGGRWVHKITGTKLGDADGHLEFTVVGLTIANQMLSLVGSIQPDPFSPEHVPKASLTTVSTASRKAAASQPPSAPLSEREVDAMIDDDDDDDDDDDGSDMDPFGKLGKMGDEAERRAREAQEAEARKEKKRKRKEAKVQEGATPEGAGEKKIKKKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQA4</accession>
    <name>A0A2G8SQA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQA4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQA4"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="3">
        <location>
            <begin position="416"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="527" mass="61533" checksum="3C1AD9EBEBE465D7" modified="2018-01-31" version="1">MAMVHPSRMGLVPQDPPDLGKRGRSPSPPRSSKRRSPSTDSLRDKDEFGRDRPGRDRNRDGDRDRDRDERRSGYGDRSRRHERDRARADDYFNDDKAGQRESRDDDRRRRRSRSRSRSVDKERDREREERREKERDSGRTRRASPDYGDYRRPSPGRARDDARDGDAGTEKAPWRQQENMYPNRGGRQPHYSGHDGGADFMDSRRLQREASTITMWPSSPKHPTRLDSPTRDSKRNKKSSKRRRDDSSDTDSDDSEEERRRRERKERKKARKEKKEREREREKDRDRDHRRHRSRSRRYSDDEDSDRERRRSRERTRSKSPRRIEDRRRATRTRSPEPRPPSTPDEDEWVEKPVAGMASSFSQPSQSGAMPPPPVPASAKGKELAFDGEDYSDDDDVGPQPLGVKTTSSRAKVDERQYGGALLRGEGSAMAAFLKDGTDVRIPRRGEIGLSSDEIAAFENVGYVMSGSRHRRMNAVRMRKENQVISAEEKRGILKLQQEERERREAILREEFQQLVQEKLKSSGAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQY5</accession>
    <name>A0A2G8SQY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_01845</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQY5"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL36185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="198" mass="21299" checksum="DBE5E6671F3532FC" modified="2018-01-31" version="1">MDKPSHLSVIVDLSPTQWALCAQSTNPPGLSLQTFLSQLMAFLNAHIACQDENTLAVFGAFPGQSVMLYSSTGEVMTTTTEVTDSNTYRPFRTLDSTVMASIAERLDSYDSAEEEAQKLKVTIDVCKIFGAENVFLQQAAHLTGGAFLPTRTSVLDMPFPIKTLQRLNASRPISAAPSIPATPRPLAQKNGGAPLRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR27</accession>
    <name>A0A2G8SR27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01698</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR27"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR27"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="684" mass="77706" checksum="C752595175CE9B1B" modified="2018-01-31" version="1">MAMLASIRATSRPGMSDKDKLEEKARARDLFDRVCKSIGTSNDGLAQLNGQAQNLTPSARKLGEDSDMFIEIAKLYQDESIERMERAYKQALQNSEASGKTEPRLVNNLGALQHLEGHFDEARTMYEDALTHAASLDQSTAEAMSTSILYNLARVYEDQAEVAKAKEAYDKLLTRHPEYADAKVRQAQMLADLNQYNEAHELVKQALASQPNNLNLRAYYTYFLVQSNQAKYAKDFVFLTLRDHDKYDVYSLCAAGWIQYHQARENRDLSPEGIKDRRRGFQRSAEFYEKALQLDPLCAVAAQGLAIVVAEDALGNLGGTLGPIGQDENAKRMKNSREALDIFAKVRESINDGSVYANMGHCYYARDEFDRAIESYETASKRFYSNQNVPVLLCLCRAWHAKANKDQSFSAMTTALQYAQKALHLNPFDKAILYNIAMIQQKAAELLISVPPAKRSLKDLQKAIEQAGHAQKLFASLASDKSQVVPYSRDIADQRRKYGESMLRRCEEHLATQRQWEADAQAKIEAARQRRQDEKDRQDAAERVRQEELRKQAEKLAEARRIAREQAQEWTREVKRMESDEEREKAAKKAKRGKRSEHVSGDEGVEGEPKQKKRRGKLKKSSDSGAENDDEALFSGDEEEQKPRKRTKKRAVRDDDDDEPAVSAPRKKQYKSKETISDSDEEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR50</accession>
    <name>A0A2G8SR50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR50"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR50"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="125"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="700"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL36230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="837" mass="93662" checksum="58F47789A8F346AD" modified="2018-01-31" version="1">MTPSRSEYQPLVQTVEDEEADVSESLPQPATARGLRRANRPVHIDLRNLDTAFKRWTESIAQKVKRKKKVEDNSKKDIWHSVFEPQYIPSGVPTGPVKTLDHGPPMSASDFEGYVEAVREAIAEGIHPKMITKGSSGSYFARAKVDGRVQTVAVFKPKDEEPYGRLNPKTTKWLHRQFRWIIPFGRACLIPNLSYISEAAASLLDERLGLNIVPRTQLVSLSSQAFFYDWLDRNAAKKGKPLPEKIGSMQFFLHGFTDASDFLRKHPWPGRAISDTFDDDSHRKGSFYKKFLGALKVVCGKTGAEEDYDDDDDPDRNMLFDRTESRSGEPFYWTPALQDNFREELEKLVILDYLMLNTDRGADNYMIKFCEGDHSKSLVDVAPSRTSRPDMPMMTELRRTDTIGSGHTIIGASVPPVYAQTYSSNLPYTKQPHIHIAAIDNSLSFPHEHPKGWRSYTYGWLYLPVTIVGRPFSQKTRDHFLPLLTSKAWWAETTFELRKLFAVDPDFHPKMFRRQLAVIKGQAFNIVQSLKHADEGPLELTRRTKVLVWDDEIPMTEDMFRDVEAANGSATPQHVPAFSPHASVASMPPLPIQPRRVRSHSASGFPPPIRRTSTDMRGISRPVSFSAKFQRVHPATTGVTVLEHMERLDAVEAGLKRLGVDEDVVVDDEERVTVEVEVDVGESSSSVPAKALRIPLPASATPTQATFGSPSVSRESSMSETGAGPSLLSPASQTERLPVVVETEDTDSVNGQALAGEEEGDLSMSFAEEDLVAMSKSTSHIEVPHSMLHTRFTSQSAIQEEPGLEWIHNDPADSAKTKMVIIERLETVHTSPLCSCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRV7</accession>
    <name>A0A2G8SRV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRV7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRV7"/>
    <dbReference type="OrthoDB" id="245697at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13945">
        <property type="entry name" value="Chs5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="80"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="168"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="48910" checksum="31B738EB15652951" modified="2018-01-31" version="1">MAVSQDSFMFTVGKLDAGMAILLGERAHLIEFPSLLLPPGVSTGSIVNISVQRNVTEEKRRENDFWGLQSDILDAYGTDTPANPQLELRNITQTSVTLEWPRLELATSKLRSLDLYRDRQRVAAIPSPLNNTSTKVSGLQLDTEYSFQLVLRTTAGVYPSNLLRVRTHTMTDTSGISVCFGTVEDEVLLENAEVALGEMGAKWSDKIQIDTTHFVCTTPAATPSAVSATGGTVTGPGVEYQKALQLSIPVVQPQWILACHTEKKMMPIRPFYLGENPSSPSHFRPQSMSQANLSSPTQRSANSTPTQQKHAINRQSMPPQRVSAASPPTSAAPPSARRIPEEVEPGSGDEDGGEDQSGRTRKGTMSKNFRFPPPNPAPPPPPVPALPLASAASADKGEGASDSKGEDADADMTVVGVVTPSSVEVPPPPPVEKERPLGSANDLDDDVGETEEISLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSE7</accession>
    <name>A0A2G8SSE7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSE7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSE7"/>
    <dbReference type="OrthoDB" id="870at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="571"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="813" mass="89145" checksum="AF1DD205C39AFAEF" modified="2018-01-31" version="1">MVQTAVEGKGKARERGPEPWKMHRCSIGHPQTGEVLDDGLAVFFKGPRSFTTEDVLELHVHSGRAIISSVLNAISFFPFCRPAERGEFTRRAFEGGRLDLTQVEGLRDLIDAETESQRRLALRSAGGATRARLETLRNEVIQCLALVEALIDFGEGEDIEEGVYDQGEIMRSGIRLAIFGPPNAGKSTLLNFLAQREAAIVTPIPGTTRDVLELSLDIGGLPVIVADTAGLRKTDDVVEKIGSSDVSLCVLSAPEALTGSAISGFSLDIPSTIVPLLKDDTFILLNKTDLLPPGTSPPNLVSHEMWSVSLGTGQGTQLFMDRFGKALKKRYLLQEGGFDGDEALITHSRHRTHLESSLQFLDAFLTTAPEDIVFGAEELRYAAQAIGKISGLIDVEDILDASGFHSFPPAYPLLHIDAVNTALSNSRRTSDVDPVLYVQGLNLENPSACCHVKRGELRYLCPVSGDVDPLYAFAFLQTFVDILHEYFGQMSSETLKDNFDIVYQLLEETLDSGGHPLTTSPNALRDIVLPPSLLNKVLSVAGVSGLASSSATSHPFASPIPWRKAGVRYNNNEIYFDVVETLEAIVNKNGTPAVSTVWGRVDSNCKLSGTPDLLLSFSNAQSLHDCSFHPCVRLQRWSRDKVLSFVPPDGKFKLMDYRYAPATASAVAQTSIPIVFRPTIQIDEHGGTIDVTLSSRLSTRTMENMFVELYLGEGASGASCIASHNASWSYSPKTQTLVWEIKQVMPSASYNLRGTFSSTAEHPRPSRAFRIRFKILQHNFSAIKIEQLKLTGEVYKPYKGMRGNSLGNIEWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST47</accession>
    <name>A0A2G8ST47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST47"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST47"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="412" mass="44866" checksum="4F630FA5D8C8F31C" modified="2018-01-31" version="1">MLGRAKWDAWAKHNDLDSYEAKWLYVDALLKVLRKYSDKTVARDLVRELESYAGDPANLVMSGVSARSPGSSSSSSSVGNLIPSSSQRPAEYLQTHPHGAPHQPADSGALDSETDEETSDEEDEAIDTVPATIPTAHVTPASQLDRPQSSHSSRPYRTPMASTLLVGSPPPINVPMTQPHPGFHTQSAFAESATSIPSSSVYPTTTVSYPEQARSPPSEPVSSAHGYPSRAGLRPQTQTPFRQYSLQSGASPRPASLPLLERVVESVQAHLAAITERLETLEGVLHHSSSSLTASGLPARRGSPFGNGQGVVRWDVDDMGMWSLVLHPMARAFRLFRQLMAFLASSEGRSPTFVVVRRLFLDISFVLCFLAVFKAGWRRSGVRRREVVAALHGLWRAVAGHQLPRHMVDRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STN8</accession>
    <name>A0A2G8STN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00829</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STN8"/>
    <dbReference type="STRING" id="1077348.A0A2G8STN8"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013970384" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="319" mass="33821" checksum="0DE4F29301D4A532" modified="2018-01-31" version="1">MSSFVLLLLSTLALASFTPTAPGPGDSFAAGSSCTTKWIPDTPGGKWTDFAIFLMTGSNNNMTRLATVVSGLDGTDQSRSLYSWPCPEVDPYSPIYFYQFTNRADMQDSQWTTRFTITSASGSSEKPEYDKQPNGDPVPWGEGRLVSRVNQFPVSQQALSDATSQHDQSDADPDDDDSDGSSDDSDEPESGNDGAPTDADSQNGIHRHNVDASPNEPEPSSPPGLASASSRHLTGNPTGSVSQALFPTVNLPETMRPAHAQPASLSASAPNSSASCSQMGPGISITDNAVKLASAACTREDRRWQGAASLYWFLAAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STP7</accession>
    <name>A0A2G8STP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3 10">4.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_00775</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>orotidine 5'-phosphate + H(+) = UMP + CO2</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3 10"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STP7"/>
    <dbReference type="STRING" id="1077348.A0A2G8STP7"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000114">
        <property type="entry name" value="Decarboxylase,orotidine phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="11">
        <location>
            <begin position="34"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL37083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="30605" checksum="F8D8ABCBE3AEB46A" modified="2018-01-31" version="1">MASVAKQTYAQRAAKHPNPAAKALLETIERKRTNLSVSVDVTKREDFFRIVDTVGPYVCLVKTHVDIIEDFEPSVIERLKALSEKHDFLIFEDRKFADIGSTVALQYSAGVHKIASWSHITNAHPVPGPSIISGLKSVGLPLGRGLLLLAEMSTKGSLATGLYTEEAVRMARANRDFVIGFIAQQRMDSVGLRKGESSPDEDFLILTPGVGMDTKGDSMGQQYRTPREVVTESGCDVIIVGRGVYGKDNGSNAEAVRAQAERYRAEGWKAYQERVGIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STU0</accession>
    <name>A0A2G8STU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STU0"/>
    <dbReference type="STRING" id="1077348.A0A2G8STU0"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000018">
        <property type="entry name" value="E3 SUMO-protein ligase RanBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="18"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="199" mass="22618" checksum="7135CAE996937D78" modified="2018-01-31" version="1">MAEPSDALAPREEEHDPQFEPVIKLTEQVETKTHEEDEEVLFKMRAKLFRFATESSEWKERGTGDVRLLQHKETKKIRLVMRRDKTLKVCANHLISAEMRLQPNIGSDRSWVWKVAADYSEEPATSETLAIRFANTENAQQFKDEFEKAQKHNVGLSAGAPLPEGTSEEAPATEEKKAEPATEEKKEGEAPAAEEKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STX6</accession>
    <name>A0A2G8STX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STX6"/>
    <dbReference type="STRING" id="1077348.A0A2G8STX6"/>
    <dbReference type="OrthoDB" id="3229989at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="16450" checksum="655EAC0846F148FA" modified="2018-01-31" version="1">MDRFLAPQSPEAQAHTHLTENWFTWDQDHPSLDETLTSGCATYQAFQRYLTGADLYLVPRTRNELESVLRRYAYDAIHNTIAKSRSQLERGGYSRMCHLVEESIRKVLNENDNAATLLDLHRPHHEPRMTDLNAATRSIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUL0</accession>
    <name>A0A2G8SUL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUL0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="178" mass="19528" checksum="99AFD5F698479793" modified="2018-01-31" version="1">MQYSRCSTSLSGGDSRMSMSEWTPLLKTMLQSPDESMSSPMLRSPLLDTRIGEDEQRLVEVVVTLAVDEDDLVALDLAALLRTWPRTAPGPPVASRIWHALLRSLAWGKKASSALSRGIWRGSHATHKGPLTVQHPWQMQGRTSEHGDAEEEYGSVCTCAEGGAWRLGQESAEQALEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUR5</accession>
    <name>A0A2G8SUR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUR5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUR5"/>
    <dbReference type="OrthoDB" id="2758338at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="498" mass="57003" checksum="6C0C8D4186E80308" modified="2018-01-31" version="1">MKFVGLLESPSHFALDNHDMSCEGPDVYISDREYQLHGWPLILFLGGLLICSLLLLETGSRGFKRVRGSFRHECQKATVQLLRAVRRRSSSTPTTSLDQLPAELLHEIFLDACTDGGSTGCSLALVSRSVRVHSRAARFHSVTLASGSNRKVRCFLRELDKATSVAAAEGSATPKVRHLCLLATARYQARTRYKRSAEDGEWRIHTQYLSEEARTRVEESLRVKHHAAVEALLQTVAGDLETLCLIVQYQYKHEPLRIRVGHGCFPKLRELWLSGGDGATLVFRDPAEEAGSEPYMRPKRTLRFPVLSRLHISVVGLDFHRWSMDAPALESLRVTLSVHGLRDTERESLEMATVNAAWPRTPVLLMGDSRSVFVLSQLSQDYYTDALYVRERLQETAAHVVFVPYYMQQDVEENDQDVGLRRALKRGVRRLDGRDEGKFWRDWLARIKPIHSKWQDGRFVRDFWARFSGDKELDRIRITEKSSQSYYIEPLIHWNRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV36</accession>
    <name>A0A2G8SV36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV36"/>
    <dbReference type="OrthoDB" id="2803682at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="387" mass="42924" checksum="90802171DA07909A" modified="2018-01-31" version="1">MEPSDPVILVHAQLPTVRPGGPGYLDPSTWVWVPCLEFPIERVNELQFSSKPLKWIRYCIGAVTGTQGHLSHQADVLAIVDYDKPLSSKSESQSMALYYHVSDAEKEQMFPTDPHLADPPREDSVHSDGNTTTSSAPCRTFHEDLVERDECCVATRWQENVCDSVHLIPHCKGDDYIRMLTTSRSRGRAEDIVSSIDDVRNGILLHCGVHIVLRRTVAFLPLPNFAMNASDVVPGADPSEVMYPVHAFGPDYKDLLARARLTLPSPERTWAARNWPPPTVFEVVYGAAVLHEFGVPETFARVADAWEELYYPQGGWAASNDAYFAERHRARAEHDTPRQHCTVSGSTRSEAGCQVPVARPPDGLLPTGKTRDIPSAQHVTSGARDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV73</accession>
    <name>A0A2G8SV73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV73"/>
    <dbReference type="OrthoDB" id="3264173at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL37669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="245" mass="26221" checksum="2D4897F83F9931CF" modified="2018-01-31" version="1">MISIGLSGPELWIALPGCPKRDRRWGPRLTQTLARLALLSWFRGPARGNKPAMVLGRRADGQSYDVTAISPACGVRDESAAWSPPILEAKLGGAPRRDADPAGAAPVGMKHGHLWDGAPGDTPGTRDRWTEADLANMVQRTAEVSATEIGQFHSQRPPTTQASVGYQLLLSLSSQMIGYPCAGIVFQLLVSPSSMIWPSALVSSVPLDTLSCNSAQKTKHVSREKSFLLIPLTRTSLPASCGRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVB3</accession>
    <name>A0A2G8SVB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVB3"/>
    <dbReference type="OrthoDB" id="3270220at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="620" mass="69879" checksum="AECC731CFAD09CDE" modified="2018-01-31" version="1">MDLDPVETVLRSFVPAGSSDQDAQASPTESHLQIRAIPDLQPIPSLTLETIPQDVFRLIAQAISQKKGALKCLSRTSHYMRAACMPILFSRCTAYPSGEMGIPPGAIRPYVSHLTYFNPAPPSQSPKKSTVDWDLHLMGCSEGWETLENHPAVWDVICPVVTHQTGCPTVRRSSADFRKRLPSSEPVPPPEALKRPRLELETATNPGAELDYFPALRSVSFQCTLKLTHMDLMKKCLANNSLLSVEFTRTVRWTGGHPDPRVDSPYPPNISITHLKHAPSVWRETISEMERRNMSAEIAIESQCLALITLGIAPTAEILELPMESAPIARMSELAWPRLRELSLTGRYYLRSQSTTLPRLLSRMPELRTLALCAAQPHALRLARAPILGHDPPIRVNLSQLRTLILAYPDPGDAIFSISAPNISHLSLRDWPRYYFHQDLLSQYDLERWASQLLNASECLRILRRMSLHYLEKLELVYQADHADEALLRYVASTFPCLAHLELHRYRNGGEVDYKHIAETLAPLARLRTLHLNLDFPDSTGPRTSCASQHSNTARHLAWFAAARTRGLEVADILEPHCPALEHAALLVHDASGSYWWRFRPARGRPEHERVEHERADIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVG7</accession>
    <name>A0A2G8SVG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01459</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="8"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SVG7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="UniPathway" id="UPA00733"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036243">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="57"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL37765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="522" mass="55826" checksum="D2709DD20423DB25" modified="2018-01-31" version="1">MRPPHRLASVSLVFTARLKPQFIPRHPALRYRMTSTSPFGLKEPSLVRHQAFIDGKWVDAKEGAVIRVTNPATAEELGTVPEMGLAETKEAIKAASKAFKTWSKTTAKHRHDILMKWFALMREHTDDLARLITLENGKPFAEAKGEHAYSSSFVEWFAEEAVRTYGEVVPSAIPNIRNVVVKQPIGVVSILTPWNFPSAMITRKLGAALAAGCTAVIKPPPETPFSALALVELATRAGVPPGVINVVTTQTNVAEVGREMCENTAVKKVSFTGSTPVAKLLYGMAASTLKKVSLEAGGNAPFIVFDDADIDAAIEGVIVCKFRGTGQTCVCANRIYVQSGVYAEFASRLAERVAAFKVGNGLDKDTTHGPLIHERAVEKVQRHVDDAIAQGAQLLLGGARLPGAGSFFAPTVLADVPAGALVNKEETFGPLAALTRFETEEEVIRLANDAPVGLAGYFFSKDAGRVWRVAEALEVGMVGSNTGLISQAAIPFGGVKESGLGREGGHGIEEYMNVKLIAFGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLT1</accession>
    <name>A0A2G8RLT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLT1"/>
    <dbReference type="OrthoDB" id="2647594at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="19456" checksum="B79B8847CCAD6614" modified="2018-01-31" version="1">MYTTSPSNPTARVARSAAGFLDLLHSDTVQISRSICGNPHQDAHSADSSATTPVPLYEPPPGRSSRDAPRRRHRSWNHTLPGNHSTNPSSRREKAAGDGAGMFLGSVLAGHLRPTPADDGSHLEGGDVVDEIQRAYEDVREKYEDGRAYYYGIVKRFEVPGEENEENGRGFWERQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMG4</accession>
    <name>A0A2G8RMG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphatidylserine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_15397</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMG4"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL22704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="51276" checksum="7DF3E2A574121834" modified="2018-01-31" version="1">MPRNPAEHHAVSSASPLTSPVDEIESDTPLAHPPEIQEQSSLPGLDGAPVRWFDADRKEPYTHIHPFQEQHDTSVEFFYKPITLTALGVGFTILAYVAMTQDVLREGQEKQRIGVYAAVASFLLFSMIQFRDGPFIRPHPAFWRMVLGINLLYELALVFLLFQDLDSARSMMKYLDPNLGRPLPEKSYAENCDLTVDNVWNAIDIFCLAHALGWFGKALILRDYWFCWILSVAFEFAEYSLQHQLANFAECWWDHWILDVLVCNWLGTYLGMKCCQYFEVKGYIWRGFRQTRGIRSKTKRVISQFSPHDWTTFKWEGTASFMHYFTVVLLLAVFLAAELNPFYLKALLWMEPDHPFVIARLMGVFLCALPAVRELYQYVNDPRRAVRMGQHVWLLLATIGTEMLAITKWSQGQFPEPLPRSFGQPAARRYLRRHQRNGKPKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMJ4</accession>
    <name>A0A2G8RMJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_15413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMJ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMJ4"/>
    <dbReference type="OrthoDB" id="2797442at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="153"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="39375" checksum="DEFE8A47870A327C" modified="2018-01-31" version="1">MASSTVVLADAPPTVQLGSTYGVFLVSIIVAAALYGFTVLQSFFYYQEFPKDRLILKVTEVWSTQVELLVTFTLYSKSNFDDSLDYNSFFIMRIYHLRPHLWYIPALFGIVAVGSYASVVAVFIKVEIFNQWSDTAPSGIVAPIIANWTMGNVVDIGITVVLCWYLWSEKTGVPHRTDVMLNHIIVFLVNRGAVAAGVQVLTLLTKLVMPQNFIWIAFHNMLSKVYTNSMLATLNARVGFRKIIMDSRYDQTVPPIEFSVQPSRPVSKMPPLPDKHHFSWNAYTAYESQSTSTGTGSDGYDRRSGLVSFHRDQRSLSSDQSSVTTDLTDYPRLHSLRDDHPPNLKHSNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMT8</accession>
    <name>A0A2G8RMT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_15521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMT8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMT8"/>
    <dbReference type="OrthoDB" id="3265205at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="347" mass="38310" checksum="55F9A4CD5244FEA5" modified="2018-01-31" version="1">MRLSYSRNGLIGDGGYGHRSIPNVLAWGRSQYFEYLVMELLGLGLDDLAKGFDALEYVHGRGFVHGDIKPSNFVLGRGDDAGRLYLVDFGFASQWTLDPSSRGHRGTVPYSSLRILKGEALPSLPRDDFESLAYAIAQVMTGPLPWFYWSTRQRLDGGTVSGTDLFPDCACYPDVFAQFVDFACGLAPADDLQHRRWREAFRALDPRLPEHPMFDREDRSGSRRWLRWVPGPPTAGHDDYSMHPDPDGGGRVEHGAEECSADVFGGPDSRSETGGAHGFVDFPSSEWSPSPVALPPCCAIGDEFDVVSERLELVDEPPLYDGGPSVEHGCPPEVMNNTQSDTHCIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMW9</accession>
    <name>A0A2G8RMW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMW9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMW9"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="217" mass="24291" checksum="CE8A0C82369A8755" modified="2018-01-31" version="1">MTVLDTTFGAALVGLVVSACLFGITLMQTFSYFRNYPKDKAYIKWLVILLTVLDTLHLILCTRTIYWYLVSNFGNTDNLDRTSWSMALQTDCNGLIGIIVEVFFARRVWMSGYTPDYLLPSILIPRFAVSKNWLITAIIVVLACLHFGLGVVFTAESFILGRFSKFGVLTWETCLGLGSAAVADVMIAASMCYYLYKKRTGLKRSVRALSLLADGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN35</accession>
    <name>A0A2G8RN35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN35"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013842829" evidence="1">
        <location>
            <begin position="18"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="144" mass="15674" checksum="B24934A18EC4BC48" modified="2018-01-31" version="1">MLYYLFALAFLVASAFAQRCQIAAPAEWSTIKAGSNITVELDRPMTLSSSIEVAIAIGFWPCNGPCNRTDVTQVLGTLAYKGPYDPQLNTTENWKPPYENFTVTVPAHFMPGTEASLNVAHFSLIGAALMPFLETLNITLKIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNA3</accession>
    <name>A0A2G8RNA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL22994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNA3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNA3"/>
    <dbReference type="OrthoDB" id="3202436at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="448"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="589" mass="64194" checksum="2EFE03414F95807B" modified="2018-01-31" version="1">MTLPGPSGSTRDRGQGQGQGRGQGQGGEGCPPNATNRHHRVDFRYGWMPSPEMPRPPLPDAALPGIEEAEDEREHRCQHECHGHHPLGPRRARPRSSRVCGGDQNQNQTQNQNLNVNLNVNPNPSLHLHPAPKRSASGSTGTSSTHTYVGGHCDHCKRSHRSSGTLSGNGAPAYAYAYNHAQQAQPHPASATAGDDLPVHVPRVRQAPAGASSASARAPSARPCARPRPPEQEHERRKSWLSVLSPKKLFSFSPRKRRSVAEVDASSGHTCLTNVNCNADADGDKDENENEADFYASTSANANVNANANAELLGRTHAAHVQVRKREVHPAEWRAYGMWARPWLGHAYGDVVVRNATPSDTPRELSPPQVEEMIATLWEDERPHPERWIPHVQSAAGRTAAEPVPRAQSARAAPLYFDLRLRADDVKLGEPEPEPIPYAHLAPLDMPLANDDPTFCEGPNGAQPATYPGVPRLRIAAVAGDAQAAFPWPVTVLPHHEALPVLVADVVHALVANFEERLAAPELDALSDTRRTMVFQAYWRRMRLPVGGRTPPETDGLRRVDYLGDAICFRGLEPNRDGDGFVLFLGPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPP0</accession>
    <name>A0A2G8RPP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPP0"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024621">
        <property type="entry name" value="Mba1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07961">
        <property type="entry name" value="MBA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="37545" checksum="1912B5C5C4E36F11" modified="2018-01-31" version="1">MSLHASRRCLDIAGRVAGGSNSLARTWSHTSSVLVVQRRCYASSATTQKSKTKPANATSSTTRSSGKAQTSKDGAAEKTRTMEDELKSVEALYRMSETNEVDVSSAPLDLMDVMVPSLRSQKDGATLGDHFRAFVQTQRNWFFNIRSLYRMANANSIPGVKVKSAWSTQLFATSSTKPTAWLTPFRQAALEVYKQANEAVAARDEKTIKLLSAGAQQREYTKLIRSQDPRYVNVWKFHGERNPSRVVSIRALEAYYGAKPPRMGSRLAVQAVVRFDTMQSVETYSKKTGARVGETQARPVTEYLVFQKRMWYDSPWVIRDRLYEGLDSRFGLPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPW3</accession>
    <name>A0A2G8RPW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_14863</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPW3"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="143"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL23550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="235" mass="26565" checksum="0825A8E5059547EA" modified="2018-01-31" version="1">MSTDPYHAVQQEIQASLQTAGTLRASFLRIRSTAREDSEELIWARNELKATLAALEADLEDLEESVNVVESTGARLFGLEETEVIERRRYVSHVRQEIENMRAEVEGGRRSRPASVLGPTSRPAEPGPEYEDSQAEWARQEQQLMIRQQDETIDTIAGTLNTIHEQAGLMGREIIEHNEMLEDLERGVDNSDAKLSTAMSKMRKFIRQTEETKSGWCIVFLIIVLMALLLAVILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ19</accession>
    <name>A0A2G8RQ19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_14904</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ19"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ19"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF6">
        <property type="entry name" value="CYTOCHROME P450 2C30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL23591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="535" mass="59846" checksum="C15340AD3C170B69" modified="2018-01-31" version="1">MSLWTSSISFARPSDFVPTFLRLAVLLSGIIIALSLLRRTPQDKAGNVVPPGPKGFPVLGVFLYLSKYPELSLHKWAKQYGSIYSFMIGDQRFVILSDPNVVKDILVTNGAIFSSRKEMFLKVQTILVHRGITASGYNETWRKHRRIAAKILTARAVATYTPAIEFEAKEMIRTLLVDGKAGAAAINPQPYASRFALNNNGHLRHPHRIHGVRPSRQGGATYLARVHQLIYHSPSLARNVTGAVSNAVDFFPLLRRFPNRMTSRAKKLHQDILDFNSPYLADIEARLKRGDDVPDCQAKTLLLTREEEELDDLDIIIMCGTLIIGGVETTASIQQWFAAHIAGCPDIQEKAQAELDRVCGRDRLPNADDEKDLPYLRAIAKEVARFHNPFWLGTPHMSTEDFAYRGSFIPKDTVVIGNTWTMHRDPMRHPDPYTFNPDRYANDKTPSADSAHLPDVMERDHWSFGIGRRICPGVILAEREVFLGLAHMLWAFKIAPIPGVPIDLKEYDGVSGCSPVPFVVRLTPRDASVAEVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRE0</accession>
    <name>A0A2G8RRE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRE0"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL24072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="72" mass="7912" checksum="929ECF3F41332739" modified="2018-01-31" version="1">MSEHTYKFNVKMTCSGCSGAVDRVLKKTEGVSSYDISLEKQEVLVKGTIGFEPLREKIAKTGKEIISGETVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSN1</accession>
    <name>A0A2G8RSN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSN1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSN1"/>
    <dbReference type="OrthoDB" id="2678231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="318" mass="35471" checksum="3CED8F6D54DBBE3F" modified="2018-01-31" version="1">MVKHATPLLQRALPSAPIQRLHKPARRPSTRYHNQNPPCVGRTALAPRSPGPRPRLHSTNTNRFLAARTELSTISEEPEEGTSEAQAQARTVRYDDARNVCTTAGRDLEAWPRRDRARAGPSKDRDVDMVGWDDDDETTLVTMLQENTSEQDEEERLIALIESLKGPMAAQGASLKQYMKDAFLPAYNGIKSAHGVLEDKVDLAFGAGLLTFDEVCKKVERIALRDEDELKTAHAEAQRNMARTLEELEHAYARRKELWATLEEDINRCATRAAAALEGLPTDMEQTIALLEKKAKALDKDTSAAANQKMLRGLLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSQ8</accession>
    <name>A0A2G8RSQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000065">
        <property type="protein sequence ID" value="PIL24539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSQ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSQ8"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF42">
        <property type="entry name" value="ZINC FINGER, CCHC-TYPE, RETROTRANSPOSON GAG DOMAIN, ASPARTIC PEPTIDASE DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="269" mass="29392" checksum="592A3E2D643B5791" modified="2018-01-31" version="1">MSNAGTTPAPLQLPAGYDVSKLVTQLAPREYDGKMAQDGLCFVSVASIYHSNITTFSPSFPETILWITLLNKLTEGAAELAGPHIVMLTSGTQPWADFAAFEMAFKAHFCTADNKEAAIAELVKLCKGQHKISTVQDYTVKFNTIAARTSFSAEDKCERYHTGLPYKIKDILATSGHDTSSITKIQAVALTMDQNLLVREEEQPKQFSENCFNCGKPGHCSFECKLPKKEQQAASSSGETTDLAALRAELKEIKERLSAVSVKEAKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTA9</accession>
    <name>A0A2G8RTA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTA9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTA9"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="12"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="454"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="71816" checksum="92F51969C226805A" modified="2018-01-31" version="1">MSSSPVIKESHVDVLIIGAGPAGVMCANALIQAGVNVRIVDQRPEGLKAGQADGCQPRSLEIMHSYGSSLTDKMFKRGEHLHKATFYNPGPNGGIEVGLNIWTSWRSYADYRTLYRQRTTSAGAVNAPTARWPFGVTLHQGAIEDIFLEAMAEKGLTVERSTIPTAALELSQDPEGRRDPTAYIAKASSGIRRGIVTLKNLERGDVEVVNTKFLLGSDGAHSWVRKTLGIHMEGDNTDSIWGVVDMVPDTDFPDVRAQSFIHSHDGTLFIIPREDDRVRLYIQQGPESDVVDPATGRADKGRTSPEKLLEQGRKILKPYRMDVKGGEVAWWTVYVVRQRVAERYSLHERAFIAGDACHTHSPKAGQGMNASMGDTHNLAWKVVYVLRGWSPLSLLRTYESERRKYAQELIDFDKWWSKLFHSKPRTEENQDGVTHEQFLSAFKKVGGFTSGIAIRYGSSTLVDTTHQSLATNLAIGERMPPHVFIRAASALPIEVQDMLPADTRFKILVFGGDISDDGDRAKLQALADDLSKPESFLMRYGRGDVGKWEVFDVLCFSSAMKDKVGYLDFPEFFRPHYSKVLLDDEDMHGRSGGGGYSKYGIDERAGAIVVVRPDGYIGTVVPLEGVPFLNAYFAAFLLQTDTRSAWGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTD1</accession>
    <name>A0A2G8RTD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTD1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTD1"/>
    <dbReference type="OrthoDB" id="4137487at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF2">
        <property type="entry name" value="PROTEIN YTP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013815939" description="Transporter" evidence="2">
        <location>
            <begin position="22"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="26"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="150"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="50252" checksum="DE6472ED83633C65" modified="2018-01-31" version="1">MTRGGVATALPLLFLAVSVLGHDHDDELTEEEKTAPVDTILWLHILLQAAVWGILFPTGMVLGLSRSRWHVPLQSTGFALTAAGYVLGHSHKGRSFLAGAHGQMASILFVPIALQLFLGIYLKLHIHEQTIRPWVVRLHGVVGKAYPILAWVQMLFGAIAFRGYCRDGNLGQCLAHYIMGSGFIAYGTIMALLLLVGESWVRRSGRSPDWWDSWVIMLWGIVNTFTEHRGTNWSVKDMQHTILGVLWWAGGILGIFLSRNNQRSIVPALIIILTGWAMSDHAQALMLSTKVHAIFGYTLMSAGLARIIEICFVAPKYTQDGADGDTHSERTVDASHEDINGVTSPSRAFRHLPPFLLVASGLLFMSATDEELHFVNDEGMDHVTYILIMFSIAFLMYSLIVSLIHLYTISGRNAPSMVPDNGSIELTAANKWYSPVPAAELEVEPVHHIIGDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTE3</accession>
    <name>A0A2G8RTE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_12668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTE3"/>
    <dbReference type="OrthoDB" id="3238224at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="56"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="278"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="629"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="689"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="888"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL24782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="983" mass="108940" checksum="6A4DB06BEFF2A85A" modified="2018-01-31" version="1">MLPRHSQAKVAKLSRLKVNSAPKPRPRLKEEDTRSLTAIMREKFGFEPKDFQIAAVKAQIEGVDMIVQASTGAGKTAIAAGPHLWPGNERKFTIMTCPLLSLEEEMVQTFENDYGLTAVALNSKNGGCSPEKINDILALKYQIILISPEMLQSGTFHNRVLRNTVFMRNMISMFIDEAHCVAHWGADFRKQYGTLGKLRVFFPHGTPVIAVSATLTPRVVRTIHRSLYFTQSEAQWRFINKGNDRSNVSLVVRACEHPLNSYADLDFLIPSDLRGPLDIPKTYLYVDNISIGSEIIDYLNAKIRARISSEESGMSRKARKRLRGVVRPFNATLSSGYRTRAMARFRTGHVRILVCTDAAGMGCNIPDVDRVVQWKLPKTFSHWIQRAGRAARGPGRTGIAILLVERSVYNVDLLNTTKETLAASSKPSKSKKKQPREKTDTPATKRDPKQVREYALAHGLARGASSKTDDTPTGDQPPVNEDDDDEGLHAFVQSTVCRRKVWAVAFESGIPAPTVPCCDICDPTLLDRTRPPVLPQDKRAKALKRGERDLAARERLCQWRETVYAREHPLAQYDVSGLLQDELLDLLVSHGPLSRAQVAGMLQDKWVFWQRHGEALSVAVTSLPILFKPLPPKPRRQVKKIPPRPPVPQPPVAPTPSRNPPPHRDPPSTLVQPMPHDEGFLQHTHIAPTCAPFYQPPPPHSHGALPLAPQLPPGAHASSSPAPSQYESSRMGSYRAAHTVAHAAASYVTYEEHGAPSHRDVPTHALSHGAHAGSSHTTSGSYHSSHMTTYRFAHATSHVVPSQVAAYTPEGVSASSRIAAPSHRRWYPASDPTMTPTGGVRASFSDHVPPQECQYTFIPTYISHTHPSQPTRAPSRAEFAIPSESQLLQPPLTFDPSASQAPDFMDTYSDDYYPPSHSQYTTHTQHSDTYHRTSFSNQVQWPAGGSATAGPSTHIQVAPPPTVHPPHYQYDHEHGEELEYMQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTN0</accession>
    <name>A0A2G8RTN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTN0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="273" mass="29408" checksum="A6C0DB5B7987DF04" modified="2018-01-31" version="1">MSAGNPSDWLISACTLLRKLDKRQDSQQKTIISGLLTLAVTAARLAGYLAEDELRDTAEVFRHVEEELARGSAPLQVAFSEVLGPRNNIPPPGNAVVSDHDAASAGPTEIPPAPHDSYMAPFETQTESDMLSPERMIELVAGHVHDRLLDTIIEPLTSALQQPLLRMLYGPLLDSLSDRLRDSLGQDPVLLDSLLAALRGPLSTHVLAVLSDQHSPSLATSVEDRQASSAHPLPPRPAQISTHTPSLALDPVATSLSGFKRRSTTPGNLQRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUC6</accession>
    <name>A0A2G8RUC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUC6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUC6"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001211">
        <property type="entry name" value="CBN-PRP-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="4">
        <location>
            <begin position="45"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="211"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="506" mass="56318" checksum="193D7C1A78CC6A99" modified="2018-01-31" version="1">MSELTFDTLIDDGNYLGSERARLENQLILDELERKKRARNLAVPTDDNKVKARLREIGEPITLFGERPPDRRDRLIYVLSQINAARGDEAMAVDEESSEESEEEVEEFYSPGSLELLEARRTLAEYSLPRAQKRVAQQRIDSKIPLGRIIDIRKKVFADVKSFANLGSQIGDERPISLVRFSPNSKYLATGSWAGNVKLWDMPNCTPVRTFRGHTDRIGGVSWHPKATLGQSEDAVNMVSGAADQTLHLWSLNSEKPLATMKGHVDRVARVVFHPSGNYVASASFDTTWRLWDVNSAKEVLLQEGHSKEVFSVEFQNDGALCASGGLDAIGRVWDLRTGRTAMVLDGHVQAIFAIAFSPNGYQIATGSGDDTIRIWDMRSLKALYTIPAHLSNVSDVRFFTGDELPPAFAPDIVMNGTEDDDASLDAKSSDPEKTFEEWQYRSGLYFVSGGYDGLVKLWSADDWQLLRTLPTDGGKVMSVDLSHDGKMLASGTYNRNFQIFTPEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUF8</accession>
    <name>A0A2G8RUF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_13036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUF8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUF8"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="744"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="692"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="8"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="520"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="542"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="613"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL25147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="838" mass="91309" checksum="C98C4A39E7FD3219" modified="2018-01-31" version="1">MVSLALPSLNRSSSILSSSSSRNSITHVPQSPSTSVPPSPVPSTSSSSSGSDRLSRADDEDATITFKRASIMSKASVMSKGKERSTEDLRILAAQHHMTELTYTISDIQTRIFEIQELRHKSQSSGDASNATTVDQSLATLDERLESVSKGVKIVNDALEPLLNRVEQTPTLVDNSKQEEEAAILRVHAALVADWEAVQKDIQVLREELKEDKWLTVFRTVTDQADGMMSSLEKAVNRCQDFMWQVQKRGLDENLNASNSSSAGRGDRTSVNYETFTTLLESFEAKKKHYMPATTKVLSIIDKGVQDRVTKNGECLRRHAECTQRWRNLKERISRTDSDMENLRLFFLHGPDSALSSGGSSQSGATSYSKGGYLATPPSGEKKMVRSPSSNTISRSISPFRKIARKLKGSAGAKSPAPPSGKVTPIPPPKSPAFSRQPSSEPTRTLRHRSSMFHFNGGQPPTPVTPDRPSHKYSSSLTPDSSPSRRGTDANATLKIRPAWNSSTRVEADERSGTIKQSPRRPSVSSTRPRLSDDIPPVPQLSNRSVSRSSMASGRPWSPVTSSSTAQSSASPFSMYRPPSRARTPGLSKINTTVSPPRNRPKTPSQIPAPAHLRSLSTSVSSADSSPSRAVSPTQSVSGNMSVFPPRPPSRSMIPIPSVHVQSASRPGTAMSYRPDSAMSFRASVARVATPEGLLSRMTPRPRAPPSSFKDSTPRTPLSRPSSRAGAETPDWHGEPVHYYAPGNHRDPLDTEVATIVNSIPHSMIVERVDQPLRQVPKEGEEVRAQYAFSNQLGRKVVTCKLTTMARAGKGTTKKVMCRVGGGWQDLKLYVMTRQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUH6</accession>
    <name>A0A2G8RUH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUH6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUH6"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="150" mass="16241" checksum="64B84D4813AEE58B" modified="2018-01-31" version="1">MAICRFRAPGEGLTRDVPHPLQVVLLGNADNVVLHLCHKLGWDLPPASTPNLMSGSVGGPSGPSSRLDAPRPNLKKRPSAEFEIEPRRVGNSHVWLFEGAEGGKWVDEIERKYQPTTTVSESTSAASTPLSSPPESEAGDTRQMKKARVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVF0</accession>
    <name>A0A2G8RVF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVF0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVF0"/>
    <dbReference type="OrthoDB" id="2804412at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="591" mass="64493" checksum="4ED981BB5AC7C9CF" modified="2018-01-31" version="1">MTGACEVYTKLLFKRVHGYPLWEPEPTQSGEVLIGDVGYVLDGGFYRLFNATLPADHPVHAQYGVPNGHEPLNLPDILRHHRPHALQAGPIYGKSVTAVNADASVEAGTGTFGPLAHVRFKFSDEQGAVLVLKNDAHREVLHPCRDLTQLDLKSQDIIFVCGWVKTAEWASAAATHRARDGEIAFGRDFGPAGQASFSVSATHEVSMSWEHRRGPKGTEGESEKAFKFDQCVFLHYYKVKHRPFFVPKALQSLARGDTRATQQSDATCAIVSDRDIMMLSSSQGGIPDNLAQFLAVTPPDLTVTGEIRIIHPSRRLNLNYVHLPVGMLPCHNAPISDVTLQPNTAPAFPPPMVQFVAGPPRVLPHHRAWSVSASRNRRSRSRSQPAARTLSPPSLAPTTGKPRVPQLSETSQRPFSGFSHITPPPPMRHAFLLGPAEPARPSSAELWPCLPLPGSPSASEGVRMSACVFADADELEYDLEDEEEDDDFLALGNGDGDGGGWEPDPAPEFGPGPSTSALLSMEEYERLVTQRPDEDLSTPESASSEREGKGKGKGKDKETDEKRARSPEEATPEREEDEDEDGRPAKVCVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWJ9</accession>
    <name>A0A2G8RWJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_11448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWJ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWJ9"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="11">
        <location>
            <begin position="33"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="43684" checksum="D5CF15F67E98CC5F" modified="2018-01-31" version="1">MLAARASAARSASRIARSARRFATVVDSAGVKVAAADNGEPTTAVTFLVKAGSRYEPKPGVAHALKNYAFKSTDKRSALGTVREAELYGGVLSSSLSREHLAVTAEFLRGDEAFFVDVLSSFLTSTKFTRYELNELVGPTCEAESTAAASDPATRALEAAHALAFRSGLGNSIFAASGHHVSSEDVKAYAQSVFGQGNVAVVGTGIDATTLEKLLEKSLGSSFASASAPASAASTYFGGETRVDSHDGPQTVFIGFGTTGAPSTELAVLAAHLDPTPSVKWSQGTSPIAAKLPVGASVRSVLLSYSDASLFGLLVQGETSADVKVAGQAAVQALKAAGSLSGDDLKKAIAKAKFTAASSFDVREGLLAALGPKILSGTSASVAEAVSSFEKVDASAYSKAAASLLKTKPTYVAVGDVASLPYVDELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWL4</accession>
    <name>A0A2G8RWL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWL4"/>
    <dbReference type="OrthoDB" id="2801217at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27014" checksum="26A6163ADC2F9F11" modified="2018-01-31" version="1">MDPHVQLSAEQSPKTTAEVAGMRNVPYREAVGSLQYASLGTRPDITYAVSVLSRFLENPGRAHWEACKRVFRYLAGTKSLRLTYGGEQRDLVGFTDADGSMHEDRKAISGYAFLIDGGAVSWASKKQEIISLSTTESEYVAITHASKEALWLRSFIGQLFTPFAEAIPLNSDNQSAIALTRDHQYHARTKHIDIRFHFIRWVVEDKKIKLVYCPTEDMVADVLTKALPSPKVKHFASALGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWV1</accession>
    <name>A0A2G8RWV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWV1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="298" mass="34224" checksum="AFFF7FBFFFEB1EDE" modified="2018-01-31" version="1">MRDWVVPYEALSGHSNLVVVSGCPFLSTCYKTFSSWLFKKWILGPCDIEVWDWKIGKRLRRSHYSFNTSFTLLDDAHRYCERRVRFSPWVYLPGVDQYESRSSIPSPRSPGEPFWIDRALWMVVVKLATESALLIPYKTFLHHRSAALMPSRKHSIPGGNEPLLRRLAWEDWSTQAFRLVGAEKKYPKWSFEYCHSYGSSVVVNADGRHGGVMFDLNPWAARNARRFPKPSGEYEAPKELFSTEGVTLPHGEVLNGWYHCMGLGQSTPGLATDPMGFTEVYSMSLRSRRFLGSISHYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXG4</accession>
    <name>A0A2G8RXG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXG4"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="345" mass="35531" checksum="DBC414B9F35E79AF" modified="2018-01-31" version="1">MSSQQKALLLPSKGAPPVVQATDIPQPGPGELLVKVEAAALNPIDWQIQAFGLFIEKYPCILGSDGAGTVVKVGEGATSFAVGDRVAFQGSLDPVQKSLSGTFAQYTLAIPVNIPFDAASSIPIALPTAALVLYNEDPSTQSVRLTPPWAEGGPGKYAGKSAVVLGGSSSVGQYVIQLARLSGFSPIIATASLHNAEHLKSLGATHVVDRNLPAEQLQGEATKLGGGLFDLVYDAVSLPETLPIGNALTTPEGDLVVVSPAGLPQGGEANKKVHLARGLLVMPTNHIVGASLLAHLPKLLEDGDIKANRTEVLSGGLAGVASGLERLKNKQVSGTKLVVFPQETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXI7</accession>
    <name>A0A2G8RXI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXI7"/>
    <dbReference type="OrthoDB" id="2729829at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="325" mass="34785" checksum="760FEA5563CA2B2F" modified="2018-01-31" version="1">MGPKPFDLAAALTSWSTSAPGQPPTPEFKGKPKRKDDPTAEAWLDLVEQGCTARRVPKAHWPDVAKHFMGKKPRGRVAEVEKVMHALHGEQWVWTWKNFRVAVLNMGWNIDEQKTREVKVERKATGLWRIVAGNKGDSSPSNTSPGPAQKTESKIVPPSRKSSLADTKPNQPSPSPPSRKSTLLRKEKEKEAEKPAEKDESTKPKEPKAPKPPAPPRSSSLFSLPAFPGIPGLRRTPAQAEPQTMLAKVTAQVPLWLLATTEALATLANDNPDVLTAVATVLVAVGTVSGGGSAAVAAIGEAAIVVGRAIKSAHDRVHGSGAQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXM4</accession>
    <name>A0A2G8RXM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXM4"/>
    <dbReference type="OrthoDB" id="2757784at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="496" mass="54677" checksum="D03BFFA92D256B5E" modified="2018-01-31" version="1">MASISIPPPVHSVYVARILRLQPELGGMFADHMDMLSLTRWRLTCKSNYWQVSAALRRSLLSLIRPFVPLPHALLEIMLKYHAVFGGELALSFVLRDPAYTPADLEIYTSDYEFGSFCAAVVRDPHIRGRAREYELVTHNALYSLRRLVGETLHIRLSNGRSIYIRRSYNSSAAAPLSRTPCTALSNFVSPYGFACSHPSLTLNRRALLADLQTPFLVDLDVAVMTNLRAHRFSFATSPSEWPEYRRDIGPLHIYRPSVSTLHPDTAAGALHIVAVNTRSIVGAVQDTTTPDAGDPAGPRPFIGNLVPAPPVNIEPPGSPPHHGAVHDISGSASLTVDAPASAAPGSEHTTVPPRVYGGAFYGTDCWRHRFVCPSQSRYFGDRGSFIEFFDPLGGHEALCAAKNIAPFGPMVVWRIMSSYECVDDCGICDDIMEEGVTSIAVLFKQDPYVDLRYIASNRYTGRRATHDPFRFASYAREHESTFSSYTVGSSPYSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXV6</accession>
    <name>A0A2G8RXV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_12101</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXV6"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL26345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="308" mass="33816" checksum="F72478194511B652" modified="2018-01-31" version="1">MAGGNQALEVNPPNALFNLSRAGSDWLWAVFSLFGASLLAILGWTFFTPRGMRLFHQIAIVVITVGCVSYFSMASDLGATPVLVEFRRFGTRQIWYVHYIQWFISFPLLLLELLLATGLSLSDIFTTLFMSIVMVIMGLVGALVPTTYKWGYFAFGAVALFYIWYVLLWRGPRTTFSAGGSIRDGYNVAAGYLSFLLLMYPICWALSEGSNIITVTAEMIWFGILDLLAGPVFLFFFLYKLRGVDYAAFGLQSGKYTDTETVHSHSGHEKSANGHNDVRGNGNTNAGNVPAAIGGPSMPMPVPVPNPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY80</accession>
    <name>A0A2G8RY80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY80"/>
    <dbReference type="OrthoDB" id="2748798at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="354" mass="40246" checksum="B6FE2A4825264060" modified="2018-01-31" version="1">MSDATDTRPTKRTRLSGDPPPDRGKDSSRSSSKPQFKPAAEFWFDDGNVILVASPRRVGFRIYRGLLASQSTIFSDMFASSSASPEETFQGCPVVQLSDSYHDLSHLLRVLLPKSRIHYQPTDADPVRTFGEVSALVRLAHKYHVQPVQDQAIAALRLFDFTDDFNTHFTGVINNTRSLMTKDEHAIGAVNLARLTDTPSMLPLALYHCAYLGGALLDGWKRRDGTVEQLSRADLQRCIEGRITLAEEQRILVYRLFDENASGDCDRPWVCHDMLRNMQENTMLSRDYKDCPALTDWTAAWDASALCEECKEELGRRNRRLQRQIWNRLPEIFDLEVEGWGEPESDDDDDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ89</accession>
    <name>A0A2G8RZ89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ89"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ89"/>
    <dbReference type="OrthoDB" id="3265205at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="410" mass="45916" checksum="B4186DBDC4564A6D" modified="2018-01-31" version="1">MRISYGMELLGRGRHGLVWATTVTMAEHSEYVGRVFAMKKAPVSNHIRHPMLLHEACAIVLLQGHPSIPKGVAWGRSQFFEYLVMERLDRNLEETIAAQGQGRLTLRNLVILMSQMQLDVIEHVHDKGILHCDIKPRNFVFGSQSEGKGGRLHLVDFGLSRPWIDPKTGQPFPEELNVSFRGTLHLASRNVHLGHTPSRRDDIVSIAYTLVKLLTGTLPWGEAKTQNEVLPILYAHTGSTLCQGYDNVFAQFVDYACGLQYDETPKYQRWRQAFLDLVPGLSADAPFNPEDDSEPRVGVQKNENDDLLRCEDCPKAPVYPISDFFQNRVYGCESQSSKGGKHGFVPNWGSSWSCGTPIRAEEVFGDEFAVVKESLEFIDAPPDYSNGPCAYEGLAPPEVIKNAQSDLHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZJ0</accession>
    <name>A0A2G8RZJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZJ0"/>
    <dbReference type="OrthoDB" id="2713066at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="685"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="699" mass="76927" checksum="ED72AF7244B3C680" modified="2018-01-31" version="1">MAEVIFDHVYKLHGLPERIISDRDSLFTSIFWRTLHALLGTELRLSSSFHPQTDGATERANRTMTQMLRQCVRPDQKDWVLHLPAIELAMNMARSETTGFSPFYLNYGQLPRSLVWQAESPYPGVTAFAARMKAAIMAAHDAIIGARIAQTEQANKKRRKAMFQEGDLVYLSTKNLTIPKGRARKLAPKFLGPFRITKVIVEGATYKLDLPHEMLARGLVNAFHASLLRPHYPSDDRRFPGRLYHQIPGFGENPREWAVDRILSHVGRGSEAEFEVQWSTGDVTWVPHADIQHLQALSEYLEALGVLNVGKLRVAPAPIGSSSTSPPNEGGPDLALNAVRVQLWDAAELENFVLGDRGDIAHYLGYKESVICAEGSNTGPQTFHHHPPELATTDMAPANPNAYNTEDWARWELYAQQLHAHFRGQGRHPGDPPEGYREVYTTRHLYAPLPENRPVPVLQAPNNQGPPQFQGMRGVAMSEDAFAALLQQSNHCANLITRFAENMQNPRPARPARPVTIVTPAPIAPVAPRAHLAGRGRGYGQRGGHRGRGGYNGGRGHAQPPPPPPRGGGLLGRMDRTGLRVQGQRGGRGGGTHSRGRRGGQDRHDRDGGPSGGNAGEPHVDDDSMRRVLDVLADIFGEAGLEDRRQDAVDDPMDVDALHAGGAEPQALDNGNSGRQRSVSPEVESVSKEIRSFEDEGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZP1</accession>
    <name>A0A2G8RZP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZP1"/>
    <dbReference type="OrthoDB" id="4584900at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013842832" description="Transporter" evidence="1">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26963" checksum="7AAFAE781B986117" modified="2018-01-31" version="1">MVFSFIRLLFLSLSVASALARLPPRSILDGSSIPDTNHSLHTSKDASPADSQVSPPCSAPIKGYIRVSSDYPLLNGYLAPDVNLFGYYTAVTSDTKKALSASFCPDDAAGGKTFNIYTSNSNPAGACLGAQARVMSNGTLNDNTNDMQYPYLVPTGERPNGPPTGTRNPLEVDTVFVQSSIWKTDPQAERMVLTPFWTNPNGSLFLATLSYEGPDAGFGRFQLANSRCNPLLFPHVGDPWVQITDVHLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S095</accession>
    <name>A0A2G8S095_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S095"/>
    <dbReference type="STRING" id="1077348.A0A2G8S095"/>
    <dbReference type="OrthoDB" id="3269050at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="258" mass="29426" checksum="FE21EE6A79E72CB7" modified="2018-01-31" version="1">MRNNFDDGNQWSLDKERKYRRYLNDVATSAVPYGDFDCQLFFCEGEDGEFEEWLRHSVEKVYRSERDTYERLPLLQGKIIPRLRGVVKYEVTVPDACDDGSTVTETIPGLLLEYVSGSTLRQLVMTWTARDPPLPNTVLATLCEEVVKAVDRLSDFDLLNRDVRIDNIMIREPFVTSSSSVGELTIVDNPVVVIDFGLCRFRGENEDEASWVKSKAVADETGAAGVVLQRLVEDFVGRGVWVYSRVYSERYVLVLDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0F6</accession>
    <name>A0A2G8S0F6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_10371</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0F6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0F6"/>
    <dbReference type="OrthoDB" id="2273864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="13">
        <location>
            <begin position="134"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="12">
        <location>
            <begin position="412"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL27227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="55005" checksum="42E7207118DC6F46" modified="2018-01-31" version="1">MSVVPEKALLRRICECGEREQEVADALSKLDKLGLARLQNDLVDWNTEQGLLLYRGRVYVPKEDALRAEIVRIHHDLPPAGHPGQAKTVELVTRNYWWPGMVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNVLQLIADRHGKIIHLIPCTEEIDAEGTADNFIREWFRLHGLPRKIISDRGPQFSSKLFRAMGNRNEEIEAYLRMYCSRCCDDWVKWLPIAEFAFNSHVHSATGYSPVYLMYGFEPQFHIPMLSTAVPSADERREELRQAREDVTSALTLAAERMKEYYDRYVHDAPEFKDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESRWYGRWKKLQYLVHWMGWGPEHDSWEDAADLVNAPKVVQKFHSTYPDAPSPFNKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0J2</accession>
    <name>A0A2G8S0J2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_10398</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0J2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0J2"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL27254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="37881" checksum="2D4D35E16F400EC8" modified="2018-01-31" version="1">MSYYTNSSSPPPLQHPVPTHPAYIPEPPATPMSPQGYQRYTSSPSAPNYPQPVPNPSHSAHLSASYPSANQYQPQPHQSHLQGHIHPPPPVDFSAWGLDNATAAFGMQLGQSAVAAGQEYVQKNLGGFIPVSMLKHHFNVSNSYVLSKFRLLLFPWRHKPWSRNIRRLENGQSEWAPPREDLNSPDLYIPLMALVTYILLAALHSGLNARFHPEILGVTASKAIAVVLLDLVFVKGGCYLLNIPGGLSSQFLDLLAYGGYKFVGVIITLIAGLLGFGRTLYLLVFVYTFLSTAFFLLRSLRSMVLPDASATAAAVNPSQRSRRITFLFLVAVSQIFYMGILIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S109</accession>
    <name>A0A2G8S109_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S109"/>
    <dbReference type="STRING" id="1077348.A0A2G8S109"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="352" mass="39776" checksum="E1C435070FF61893" modified="2018-01-31" version="1">MPNLDGFNGRDNGTQPPDGELPAELLQYTKERLPLDRRLDRLKKKFGYIIGTTHIVSNIIRTTKLKKLNKKFDIPSARWPLPLPVATAVVCDAIATDVHKRNGPDTVMRIISSQGKYAIPRSITRAIMRDNDPLGFEVRYHASRAPIPRGVLTAKGLNHEGSADGHEKFSSMALQMGPVGFGIYAFREKLSGCILHGAVVPNVRKASTIGHVYLDMVSVHGCIFCQLTVDHGSETGDMYAAHAALRRLYAPELDETEWKLFVAITSTHNVCIENIWMRWLKTSGRNVQSIILQGKTNSLFNPLDEVDMYVILLIIDTVEMLIKSLFSNLFQWLWPQIVQIEFDKFMDYWNCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S165</accession>
    <name>A0A2G8S165_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S165"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="16239" checksum="1D1460B5FB2DEC08" modified="2018-01-31" version="1">MVPPPLVVDFLWLLGNHIGISTLGTPTANGKLSCFLLPNPANAAYMGEVSLDITLLVCRPRTPRKRRPSCHSCLRGSNPLYTRRASLSRGASSDCSWENGRGRYDRWREWWNYSGGTRGQETRDRSEGRRAAAGDRPCSHLVQGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1N3</accession>
    <name>A0A2G8S1N3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1N3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1N3"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="872"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="880"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="918" mass="102365" checksum="2E262A14FFEDDDF8" modified="2018-01-31" version="1">MGRLNFDIDDDALLKAYKLSSASATQWEEVDQDMDNAVLGLTGPGEIDTDPLGLGVTVDLRDLDSETKAAVLITSKAFDPKTFLSVAHPNATYQDLSAGIAHLRSSLDSRSQAIRVLVEENFDRFVAVKASTDALYAEMKEGILADQTEFASQPLKNHLKAGAQKADQVFLPVLENAMKAQKLRTTLGVFDRSKFFFNLPSSLVECIEAGRYEAAMRDYKKGKLLLETRPNQLLPIGTTKDGQSTESAVQQQKRILEKVWATVEKVMGQMRNELLAKLQEPSRSVEEQEKTIEILYEFSSSDDPAWTYFDAHHMHIMQNMKDIYATAVNTVQTLYDKAPVEPPGRTSLNRELASQLQTCVQAIEAKQPDMVIAVSAGQDIWEAIHTMVKNVSEAMLIPLPNFWRISKSFMEGRYKKNAATSSRRSPSQCRIMALDIIKLYISLLSEFFMFSDMAVMSPGRDLTPPLFPKTSNSLTTAHHLMKVLGEIQDSVNDVTGMEISSEATSSLKSLLETARWKFEDLLVNAWLRDANIFYHLETWVGSTVDPYTTIYLSQMRLFQKQVTTSAFKIAGGVDLSTAASSSRQTKQNPVASEFVTKIMKAFLDSLYAFLDGLVHLASDELPTSIVARTHLPLQTNSAPGSNPLELVKIEDADTRVLLVVSNFAHLQRALIPSMTAEFETVFNISLADEKNSLMAVVKELDKTLFESYFKPKSTAITAIVRNGILDPQMDWYETPQPKEIRPYVYETLMYLVGIHAQVSAAAAPLLERTLNALVQDVADEALRCFRQVKRFGMGGMLRATLEIEFMHQTLSRYVTKAADETLSELYTRISQAYAKRPGDENLQAHLDGVKKTLSDARRATGIEFLCFRATKDRTKDKSRPSAAPAATSASGSGAPSGDDGRTRERSERRRERPRPEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1R6</accession>
    <name>A0A2G8S1R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1R6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1R6"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="22416" checksum="F8A40198996E269F" modified="2018-01-31" version="1">MFIPCAAILTPTAAVRIRFFAQDCNQVWFMSFQTHLLRINSNPHWKGIDLLIATAPRICAKFPNVRFLVDVVRAISEAIEIVSAGKHDPYQAHERIKDFYDWHEITQRTELVYETVMDTEPYDFWTRLQRTLDVGPIAGIIYAIILLVDCLFFMFLEWWLPEDQMDKVQMHWSPERFQEVAVFGSLWIASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2Z5</accession>
    <name>A0A2G8S2Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2Z5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="81" mass="9042" checksum="E75A6FDF7F107953" modified="2018-01-31" version="1">MQPYTSSSGQHPYGSSERRSLTGGGQKAGPIGTNFGFYFNNFFYVGRVINTFESAKGERLLLQFLDGVQGYMRRSLCTETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S324</accession>
    <name>A0A2G8S324_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S324"/>
    <dbReference type="OrthoDB" id="2317741at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654721" description="Transporter" evidence="1">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14119" checksum="90D012AB2026875A" modified="2018-01-31" version="1">MFGKLAPVVAFLAFTMQPVFGMAVAPRSSQDVFVPPVTYPTEGAVWTVGQTQNVTWDISNAPVNITNSKGLILLRKSGITTPVILQNGFDILLGSIEVTVPWVVEGTDYSLILLGDSGNDSPNFTITGSGVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S347</accession>
    <name>A0A2G8S347_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="3">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S347"/>
    <dbReference type="STRING" id="1077348.A0A2G8S347"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF154">
        <property type="entry name" value="RECQ HELICASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="582"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="774"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="946"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="712"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL28157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112902" checksum="A2C9F1DD4DEF8F8E" modified="2018-01-31" version="1">MSNGLTSFVPVLTGPNYLQWAPKMQAFLQTTGRWMQPMTKTCPTLVATPSNQDKVDAWNEDDTAARGSIRLRVDDSIGTAINSKTTAKQVWDYLKDTYGKPGIPVVYQDFCAAMGISIPSDSNPIPAMDKLRAHFQTLETNQFTVAEHIKGMILLSKLPSAMDPIIQVYTSGLTAMQTTPAVQLVTFDEVRNHVIMYWEQRQGRHQQKPRDSVNKISAVKRKPQDPTFRQQQQRPQGQQQHQQRPYGQQHQQQRPQGQQQQGYRGRRGGRGRSQQHQGAHQHAHIAHVADTFPVITKGEMDTLPQSRDPRALLHKPVRAETGANHQYPALRRAFTLAKELGVEPTTERIRKLEMLVVAGNRSKDPVLTPTTELHSTRSSPESSATYSEDSRTTSPSVSCSPTPFAGSSVRIVEVDSGEDTDGEEHAAKRRRRTLKERIRPHLRERIGVFLTSGVMAGDREFLAPRPFHRPGDVLAACGGTRDVASMDEAHCISQWGGDFRPDYSQLSVLRTFVPQRRAPIAAFSATMAPGVISEVEESLLINPATSFYLNLGNNRANIYLQVFALENSLDFAALDALLPLGTVSRAADVPKTIIFANSRRMTLRIWSYLCEKLRLPVAGRLPIAFLHAYRRQRARVRVMDAFVSGEVRILVATEAAGMGADIPDIEHAIHFGAPPSLTTWIQRAGRAGRSPRILARATLLIEKSAFQLINRKGPRKPKKQKTSTAESATTATEKGPEYRKKIDRSLRVWLDHKGCRREAVDEYFNNPILTARSVKRPRSSSSSAPSVLSPSKRRRDNIPMEEEESSGQIQVEVAPRRIRAGGHRERAIAALKSWRLEMVRTRYKLTSFSEEGLLSDDMIASLVYDATLKSVEDVIRKLADPPWVFAPRHAKDVLAVLASVDAAHDAAQASKVKPSALRGRSARSTALTKRVASENDENIHVDVELASPFSGSSPSSPQAPIPSDIPSSSTRAPKPRPRYRADQATSPQVPLTPQAHAVGADGCQPCKRPGHSSCERKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3A5</accession>
    <name>A0A2G8S3A5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09675</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3A5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3A5"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="323"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL28263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="352" mass="39425" checksum="866B1310D4494556" modified="2018-01-31" version="1">MPFGEVVCGSPGSGKSTYCYGKHQLFTALNRPIAIVNLDPANENIPYPCAIDIGSLIKLEDVMNEFGLGPNGGMLYCMEYLEANHDWLEDRLKELDKDDYVLFDLPGQVELSTNHPSVKNIIRRLTKSGFRLAAVHLCDAHYVTDASKFVSVLMLSLRAMLHLELPHINVLSKIDLIQQYGDLDFNLDFYTEVQDLSYLENLLSQQSPRYAALNMAICSLVEDFGLVGFETLAVEDKESMLHLTHIIDKATGCIFVPPPSVGQPPDTVDASNKPSSERPNTYSLMTSAAGPIRGPRSDVRDVQERWIDAREEYDAFEKAQWRREGQLVQEEAARQKSKIRERTSNPPGSRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3Q4</accession>
    <name>A0A2G8S3Q4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_09515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3Q4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3Q4"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="398"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL28364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="54982" checksum="5FDD825E560536A2" modified="2018-01-31" version="1">MAATRGRFRTKLCRNFALGNCPQGESCNYIHATPEAIQMNTLSKRSADDQASSTTFSPSLWPTLSPATNGSSDHFAYQWSNPSTAAETTPTQSHIKYRPLSWRTTLCRHFLKNRGWCPVGEECNYIHDLALGAFAKDDARFSSRGVTVAGTTKQTQRGKAGSKHSHCWAYIQGLCHVQDCPYLHPVAIHMFAAHTPCLAWPNCRRGPLCPYKHPEPYVSTSPEDSPVQQPAALPLQPPPSHPDAVPRGAMHYNGMFYYNVPQPPQPTAPPSLPPPIAIPPSGPQPPPMVFTNPWEAWQVPYTPNAATMPYSPVAMNPLHAAWQMPGHGLGLGLGLAADSGKVMGLGPPQPMFSPVAVAGPPPAFDAAVYSPPPPPPPAAPAPALANYTYGHGYGYGCGNDGTDTEEPAGAAQTSRRPPSLSVSVSAAPESEFPYVPPKGQRVGHARRVSVTIKCRSKESEDLDALGLDTGSHGRMPWQTHALDRVGRRSWAPSSSSALHAAEPTPPPMVYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3V5</accession>
    <name>A0A2G8S3V5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3V5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3V5"/>
    <dbReference type="OrthoDB" id="2553626at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="674" mass="72177" checksum="96D963643389CF14" modified="2018-01-31" version="1">MSRPLTLHVSALNDAEFARYTASIHDILDSEPPDYDKAAVGVREARAWLRGRYPTLASHTLDSILRLFAPELGAADVLTGGQFFAVLRLVSHVLGGQGVDPSLVFVQAHFQAHKSRPSSPVDKSCQVPTPILNPFSTNGSAKPLSPSPISTVMPTPTKPPPPTLPPKPTNPFLKRRGSQDLPPQSAPAGVGAFGPRTSVPQDAKIPPLPPRKPHVLPPPRHASMNVQHLPANKEVPPVPPLPRNVSVAHTTNSLIQQSLQATRIAQSLKQAEQKLEQERVMEVLRSSSDSSTGSIKRVRSTSPTKNPSSSASSASSSADRTAMRNGVPKLPPRRNLSPPASTAPSARSFEQVATAAVTPHKRPVIASASSNGPPIPPEPPQRRRASSPTRTPPRPLSDLVSDPPPTHPDRKATASNPELDPTTPTSASPRVGRSRSLHHPTPPAPPPRRKRPESVQVTPTSPSPFDSSPFANPPLPSTPPPAANPNMRLSRHLSLSSTKRDPPDRDNNNKDRERERERSWETFSDSPLGASLQKTLSSLSARAAPALDTARYKAEGAFARRGFVQHGGGWMRREGEARLIDDVDGDGGEEGEGHAGVDVDADGEGGLGMGLDHDASGSGSGDGEGVEERARRWRRGGVDVAVVERRGEDGRAGRRLVLERDDLKWPAGEGWRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S451</accession>
    <name>A0A2G8S451_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S451"/>
    <dbReference type="STRING" id="1077348.A0A2G8S451"/>
    <dbReference type="OrthoDB" id="3265734at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013621006" description="Transporter" evidence="3">
        <location>
            <begin position="24"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="55098" checksum="ED0D00BCCB6E7837" modified="2018-01-31" version="1">MPRIWSCSSFLCACLLSADVVRAGTLDVQDNSPALVYNGTWFPDASPNAHGKHETWTNASGASVYYDFQGSLWSASARPSVARAGSQVEVFATLRPTGTYLTNVSFRIDDNAPDFWVSNKNVPQETFNKLVYTSPGTLSTDGLHRITITNYGFVFWLVYLEITTPDVSGGNSSSSSSGTSTSTASSTGTGTQSSSAGTSSATSGSASSSSSSGSASRTPVIIGAVVGSVGGATLLLAALWFWCMYSRSRRREREAMAPTPFAGEGPSPHFTKDRPPANPSSRFQRWITDSQATATEPGYGYPSTGATEHAPQERERARSEPVDAEALKQLAVFRSAAEARAAPDTTHERSEPLRGTGTGTRPRPPPAASIPSVLETPHPSTTTHSVSPRSAAAPVSRSGALARAFTFSSRLSRDPARAGARPPPSDATMSSALASSGVLPPPSLYTPPGRNRPVFFRVLRRSRDGGVRLAGGAPQELDADMMAPEEYDQQILEAMSEGSTLPPEYQQYPTTGGEGERVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Y2</accession>
    <name>A0A2G8S4Y2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08881</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Y2"/>
    <dbReference type="OrthoDB" id="2748713at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="547" mass="61103" checksum="57EA3FC920C9B4E5" modified="2018-01-31" version="1">MLGPRPVVLSKAATIPKFHAFIFSDVAARMPYLVALVIDVAEGEAYLDLESSERAIECLVAILRRALCLKSLKLLSSAGRQPFGYPDNPRLSAAIGEVASLRELTIDGQTRVVDFVDAVRSPLTRLTLCMSGPSGGPDPWTQNTLSDALIRFKDSLESLSIRGSRVQLERSSIGFPVSTLTQFHAVRSLTLNQLVTFPHLPILLELFPNLNGTVHLTGFPYYSIPDFACDEPQRYTFFREVREENGRAQERQRWTRLERLICDVDTLFILNLRCPVGLTIVHKCTACTNPALRRYLAESLRGHRSTRLNLQLAIWWGVDQPLLDSIIPPEAAARLTHLTLCVRYVYDNSPDPTPGPRYADTRWDDLWRNALLPTIAPLRLRALTHFRLVFHCQAQEGEEAARPISEEPTVEDLRPTPHGRFDFTAIASVVADALPSLRYCFMTNSAHVLTHVDARLTVVEGWRESRAWQVACDPAGSTGAAAAADTCAIPRELLEMDNSVAEALMGREDLFLSTEEKASTVKHDFSFVCVCSNTVYVNLQDAMEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5M3</accession>
    <name>A0A2G8S5M3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_09085</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5M3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5M3"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="144"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="273"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="360"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL29037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="450" mass="51270" checksum="CF11BC7AD8B04AAA" modified="2018-01-31" version="1">MTLDVLHFIDNKGGNAEEIRESQRKRGLSVEVVDEVIQMYADWVKLDFEANNLAKSVNTVQKEIAAKKKAKENADELVAKKKEIDAQVIAKRNEAKDVEAKMRQRASTVGNIVAKGVPVSLTEDDNKTLKTWVPEGKDVEKKADIMPHHEVLLRLDAMDLERGAKITGHRGYFLTNDGIDLNQALISYGLDFLRKQGYKKIQPPFMMNKDVMGKTAQLEQFDEELYKVIAAEDEKYLIATSEQPISAYHSDEWFDSPETQLPIKYAGYSTCFRKEAGSAGRDMWGIFRVHQFEKVEQFCITEPEKSWEVFDAMVANSEAFYQSLGIPYRVVAIVSGALNLAASQKYDLEAWFPFQGQYKELVSCSNCTDYQSRRLEVRCGLKTKDQTRKVYVHMLNGTLCATERALCCLVENYQTADGLVVPEVLRPYMQGREFLPWVKELPKSLQRKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5N9</accession>
    <name>A0A2G8S5N9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5N9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5N9"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="115139" checksum="38EE878E4E635815" modified="2018-01-31" version="1">MVHSPFHSLGRKFSCVFQRIACGDIEQVEEQPPKPSKLPPLPQKPERGSSATKPPSKETTPTDSKQAPSPIRLTWAQIIPESLEFSVDPSHAHFHLYQSLIDYIRSAYSPSSLNGSAFSTWRSLLQHHPSFGTLVNLLADRYSLTEEPVDTVELGLSPNSTLDFILFGLLHVVQESRRAAASGTLYYAIDRVRGHVQVASRHGIELYQAALLDFLRPMWEYECRARQEMKSSPMPWSRVSKDEKPPVEGPSELTVLIIPPEIVSMDDNHPRFRAARLQFGHPLDVPWLGGVNDGYPFSPTLSSYVKIRRRSATPSLHDDVAMWLGAMTFGLLEIATHYKVTEVDLLSSSQAEETRALSGTRLERFLFAWGHHMRESMHHGTFDKEIHRIQGRQLASVLNQALAALDEEGLQGTSVMLRAGFPVEMQVDILGALTLAIGTLCNYALSIWHGVPEMENISKQLHDTTRYFHRHTKQMCRRVMLPAGWCPHLVSTQFLNSVDELSLLSHIVREKPFTRNAPDEHAECTEAACVLYTIDIATYSARHVASHCYCAKVTLPLQDITNFLSDSESSAVPVVVWDGMRLRVQPAVDGQYVAISHVWADGLGAFSEVGLPACQIARLAALVKEAIPETGAFWIDSLCVPREPTLRSRALKLLRKTYKEAAKVLVLDASIRAQCTKEGPWEENLFRIVMSGWSRRLWTAQEGILARRLLFEFSNGLVDVTDHLRVDDHSAVLHTPKSGKAQLIHTSGNGRIDHHEFNATSLYRSCFTLVTLRAAYQNNPNHQCTIDEVIDLVRHRTGTHPDEEAMALVGLLSVDIDALLSISGPNAAELRMKTLLLQLRNVPLPLPMLQTQRLNIPGFRWAPRSFTGANESVAGADSGSCTTDGLLAEYSLARFESSVAIPPLCVQGLKDTFKIAITQHGSTCIYEAFFSMPLEHYRSGVAGLPLSVDGFIFTHEDLPKDSRIISCAAVALRTGEAEAEDGVAKDALKCDYVASVELWCSSDAEGAVEPRAQMIAAAPDVYGLYKMGNLGHAKVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6K7</accession>
    <name>A0A2G8S6K7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6K7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6K7"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="357" mass="38293" checksum="17DBD7EB33EC1E2F" modified="2018-01-31" version="1">MSLSPATASSLHISTTISDTSRNDLIQDPKPHLPTLATIPPDGGRAAWLTIAGAWMIQFCTFGYLNAFGVYQDFYTRDFLSHESPSNISWIGSLQLFLMYAPGAFVGHAFDAGYFHHIQIAGSILHVLSIFMLSLTSRDHYYQVFLAQGVGVGLGVGMLFLPSLSIVAHHFRNRRALATGIAVSGASCGGVVFPIMLNHLFSNPSMGFANGVRVSGAVVAALLAIANAIMRTRLPPKRRSFFSVFSRDYMWRVLGDHAYTTSVLFAETHGVNKTVTTYILAILNAGSTIGRTLPVTLADRLGVYNLLIPSILASGVLIFALFGATSTGGVITVAVLFGFSSGACAPQFIISPDRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6Z8</accession>
    <name>A0A2G8S6Z8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6Z8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6Z8"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="272" mass="29597" checksum="AE744340C9AEC658" modified="2018-01-31" version="1">MFPRIGPLSLSSAHSLAWDMEYKNPPPGPVTVTGGPREDWRTKGTALVERYLACVADPTPSLSLQCDTSRARGPLKAHRLLIKLIAEESAHIGRALKTLGFTFTELIEAAVAVAVFEQNPVPADKADSPCGRRGSPIALTDRLPPSVDRRRHVVSCRATTPFRIDYAPLVPLAGKARLLAAMRQQQAHYAWRLANPCLPHLLAELAPSRVATGRGRGRGGIGDPGDLDQGGRDAPCEQAGERDAHTAADVWDKNVLQEFMDEVVRQMSFVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7N2</accession>
    <name>A0A2G8S7N2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07988</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7N2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7N2"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="739" mass="79094" checksum="92DDCD855F56051E" modified="2018-01-31" version="1">MSQLSFKRHTVVVTGAGGGLGKAYSLLFASRGANVVVNDFNKEAAQKVVDEITNAGGKAVVNNSSVTDGEAVIKTALEAFGNVTILINNAGILRDKGFKNMSDQEWDQIMAVHLKGSYACAKAAWPYFQKQGFGRIVNTASAAGLYGNFGQANYSAAKMGLVGFTKALAAEGARYNIKSMVVAPMAASAMTETIMPPEMLANMKPEFVAPFVVAITHPDGADANGRIFEVGAGYIAEIRWERSKGSVFKTDKTFTPSAVQEKWEQITDFDIDPEHPQYLPDFDIKAKIAESSKITENPQASQEVRFDGKTVIVTGAGSGLGRAYSLLYARLGANVVVNDVNAHAAEAIVSEITKAGGKAVAAVTSAEDGEGIVKIALDKFGGAHVLVANAGFVRPSAFEKLSEKDWDELLAIHLRSTYKGPAPTQCPTRYGKAETDSCDQCSKALWPIFLKQKYGRIVTMGSQGGLYGLPGLVNYSTAKAGLIGFTKTLAIEGKKYNIFVNIVIPSAGASAGLGRAGGNVEAIKEEYIAPVVGYLSSDANDETTGGIFQVAGGWVSQIRWQRAGGHGFPVNRPLQPEHIVAQWKLLTDFESADDGRATNPGNAQEAFMQIVENFGNVDENGASGSDSESPYADPEDSEVVAQAKKEPQEPVEYTYTERDVILYNLGIGATEQELQWTYENHEDFAALPTFGVIPQFLASAGLSFDFLPNFNPAKLLHGEQYLSIKAPIPTSGELVNEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8F8</accession>
    <name>A0A2G8S8F8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S8F8"/>
    <dbReference type="OrthoDB" id="3226640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="372"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1075"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1362" mass="150778" checksum="328049A861F24A49" modified="2018-01-31" version="1">MTLSDPVLGPGSKDKELPGDDNPYAGRIVTHRRMGIWDWYEEKDPDASAVSLLSPSGWSESCCHLGRSFQYVVRAVKDVLGIPGCKTQFAVYLATGFGAALLPAATIWSQGNILRVMDDINQTSTVDAHRLLLACAGRIACTIATTALHQMQGLSTGRHSMVWQALQVTIRMFSTGVRLVTQTIALIDVLRGHSEERWLTWMTLAIELLASVPRLRTRGGTAYAATTRNIDYKRKRGWEMVVQRTDHRKELVAGNLAEYAIAEYTRASDSLGDENVDWTEIYRQELDKASPSLLGYFNRWILPHLTEVKNPTRLPEFMARLNLVQTSARDVGVSFSIVINTRNVIQGHIDTLRKTYETENIRNVVQDGTVPFQIESAQATSGVALEFSLRFKTPPLPCVRVNFVIVGSNGAGKSTILKLAVRLYDPDEGEILLGGRDIRTLKLRDVRQAMSVLFQDYTHFPFSIRDNIVLGDPSKAHDDAHIREAARLGGADSFIEKLPEGYNTYLKRVVGDFVSGPAEGNKTRSGKPFDVCAVQHAAGIKSTTSSELSGGQMQRLAVARMFMRSVVAEDNRVGLLLFDEPSASLDPAAEHDLFNRLRKLRGNKTMVFSSHRFGNLTRHADVILYMNESSIVESGTHEELLKDQGDDQPPDIASENKVSESPGDDNPYAGRIVKHQRIGVWDWYEEKDPDGAQLISPALGWGDSYSDIAGSLRYVVRLVKDLLSIPGCKTQFAIYMAAGFGAALIPAAAIWVQGNILRVMDDINQTSTVDTQRLFQACAGKIACTIASSVLEQIRRKANVKLDRRIQQWHARRSFEARARLDLPTFSLQSTQTALAGLSSGGHSMIWQGLQMTIGMFTTGVRLVTQTIALIDVLRGHDQERLLTWITLAAESLALLPQLSVRASLACAATTKNSDYKRMKGWEVIVQDPDHRKELVAGNLAEFATAEYTRTADSLGDDDVNWMEAFHERLFQQPLFQQYFNTWILGHLSEIIFILRAVRNPTRLPEFMARLNLVQTSARGVAWTFAGVLTNKTMVKANLDTIRSTYEAVNIRNIVPDGSVPFQVESAEATSGVALEFRNVTFTYPEASKPALQNVSFTLSPGQLCVIVGSNGAGKSTILKLAVRLYDPDEGEILFGGQDIRTLKLSDVRQAMSVLFQDYTHFPLSIRDNIALGDPSKASDGAHIREAARLGGADSFIEKLPEGFDTYLNPVVQDFVSGPAEGDRTRSGKPFDVCAVRHAAGIKSSTSSELSGGQMQRLAVARTFMRSVVAEDRRVGLLLFDEPSASLDPAAEHDLFNRLRRLRGNKTMVFSSHRFGNLTRHADLILYMNESSIVESGTHEELLKGQGEYAKLWQMQAQAFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8N8</accession>
    <name>A0A2G8S8N8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_08097</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8N8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8N8"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="85"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL29888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="26806" checksum="352EE21FDB06D903" modified="2018-01-31" version="1">MPITTPSDPQAAALLAHVLQQTQTNINFLASQDYITHAEASDLLSRLTQGGPQDSLISSVNNLAVGPARTPEPARRSVPPPPPRNNVQKARAQWAYNEDGREPNDLSFSAGEIIEIVDETNADWWTGKARGKQGLFPSNHVQKIDSGPSSASPPPMPSMPSASSYYSTPPGPPQPYYSAPPYDNQKTGMYQPQYASPAPAPAPQPPVQQVVVQEEAPKKSKFGKLGNTMAQSAAGGVGFGAGAAIGSGIVHAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAB7</accession>
    <name>A0A2G8SAB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_07398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAB7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAB7"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000031">
        <property type="entry name" value="Probable PRS4-ribose-phosphate pyrophosphokinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF46">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL30694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="333" mass="36191" checksum="25A321F6768C1F37" modified="2018-01-31" version="1">MLRGNSVRILTGNSHPGLAQAVVERLNVPLTPCTVKKFSNGEINVKIAESVRDEDVYIIQTGCTDVNDNLMELLILISACKGASARRITAVIPCFPYARMDKKDKSRAPITAKLVANMLAVAGCDHVITMDLHASQIQGFFDFPVDNLYSEPLMISYIKRNIEDWRNSIIVSPDAGGAKRVTAIADKLGVEFALIHRERKRNPGGPEKMEVLVGDVRDKVAILVDDMIDTGNTLALAARSLADNGAKKVYALISHGLLSETNMKMIEGLPIEQLVVTNTVPQKQHEAACSKLVTMDVSPTIAESIRRTHNGESISLLFGDWAEGVGVNGVGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAB9</accession>
    <name>A0A2G8SAB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAB9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="115" mass="12856" checksum="655944E17A025C86" modified="2018-01-31" version="1">MGDTGIFRRVDELHVRLLIVVLECLETLLRQPLDTLLFLLLRMRVERQDSLAQAGDALLCRTTDRDDLAPMRADDAELLDVLLLRPTLALCPLLALRDLGGTDVAELHLARSAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAH7</accession>
    <name>A0A2G8SAH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAH7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAH7"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="56"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="656"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="603"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="783" mass="86227" checksum="61E6279A7C89B7D8" modified="2018-01-31" version="1">MSSNLDSPPLETPPSEERSPFTSIPDAFFRRRTGSRWLSQTKSASTSRTATNEVSFEVEHLGDIRAFDSGWLDDDVEEVMVVTKKDKKRRPLSAVVDSASRDRIRRSPYKVKLKGDNRTMDANQFEFIRSLVGDDGGETLLARKFDNGQIYTVKLVRKMSHSAARLVARMRNEQAALKLLTKLEVAFVMRLWWSFEDERAMYLVTAAGIIGLHERGLVHTDLRPECILIDEEGHVVISDFSKARFLRGDSATYRAESGACLPEDQMFHAPELVLGWDHDYVVDWWSFGLLLFWIFTRTHPFVIDADNVHSAILHSKIFHARLMEDYPAMDESVYRLVARCLQRNPALRIDGVGVKMHEYFEEIDWINVTTKRLPAPFSSLAKDTFPFTAMGTGDSSLRLSTANSASQDLGHFSFSWQRALSSSASMESTGSRATRQRRRSVRILASPGDVTVIPSQSTAPVDPLPDIPKTGPEDVSRTVSTSPPLEDVIDPDVSIIPSLSATPSIGLPLPSPLESRVGNLRKYASLNFDDLDSLASTNSSLPAAESSGPLLGHSESTTPLRKTKSILGISLESFRDADDSASSGSGRWTSKLRRRSQAGTPTPKTPVIPPTPPVPVPSTAGLPKGVEKIGNGIGYNHRDRRQAMNLASLTPRTCHALFSGRRGKNKQKRKDDPQSEPDRGSSGAHRDKDKDKDKEDQPVGTPSAQGQGREEEIEEDLMDEVMKEIYGDEWNAGASPDPDTSGAGMPWGDVLAPGSFEKAGDASFAGPGSTLRLVTSPSTPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAK7</accession>
    <name>A0A2G8SAK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAK7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAK7"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="62923" checksum="061FB2E5AC0C54C9" modified="2018-01-31" version="1">MLATIHPRSRSPSPSSQPPDKKSRLDEPTPGPSESALARDPPTECQEPPSSSKNPQKHKKKRSPRHRPPEPFSSDDILTREVIALLGNDYVLSLTQQNLDWQSPFDLSTHLDLSVSRISPSTGESLSIADHNGVKWVIVTPLSLPAERIRVRVYRHSRLHSHADLLQVLDPNPSWRDMSRVRCQYFGKCAGCQYQMLSYEQQLDLKRDTVVEAYNNYSNIPHDLLPAIQPTIGSPLQYHYRTKLTPHFQRPPFSFQKAQKRGHAPLIEGKPDWLKIGFHQVGTRNVMDIEECPIATPVINKALGPVRDNVIKNVAKLKNGATLLLRDSLPPDPPADIPVASGSTTVEDDGHICVTDQKGSVRERVGDMLFEYTAGTFFQNNNSALLPFTSYVRDAAFPATDTSEAIVKPTHLVDAYCGSGLFSIMLAPHFDKVAGIELSAESVRAAQRNAELNALSSENISFTAGDAANIFDTVQDFPRDRTVLIIDPPRKGTDERFIEQMIAFGASTVVYVSCNVHTQARDVGQILQKSEAKAKEAGGKKYVLESLRGLDLFPQTAHVEAIAVIRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAP4</accession>
    <name>A0A2G8SAP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAP4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023908">
        <property type="entry name" value="xxxLxxG_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03057">
        <property type="entry name" value="xxxLxxG_by_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="24665" checksum="B8984CFDB3839BDC" modified="2018-01-31" version="1">MNAPAYSAQALTMPQLVPTHSFVLSNIVIPYNSNASTPYSPAIVSMQYSTGAAALAAYNSNAPVTAYDPNAPATTYDPNTPITSIPFSSTESNDAVNYDPNAQFLNHSDKDFDVLSQKSDSMTLEILKGIQQDIQMHREQDRSDMKSLKDGIETLTSGMNTLNGSMTTLTNGMTNLNNGMNRLNGGMNTFNSGMNTLTDTVLSMKNELVGLNQLLCQMITSAGAGNSGLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAT1</accession>
    <name>A0A2G8SAT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAT1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAT1"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="173" mass="17849" checksum="EB76EAF9A4965A47" modified="2018-01-31" version="1">MLHTTPDDVWDIIIRVHVRAPFRLVRAAAPHMRIKGNTENRSIINVSSTSGLHGNVGQANYAAAKAAVIGFTKTICKEWGPFGVRANTVAFGFVQTRLTAAKEAGASIEIAGKKVALGIPQAPAGKGLNPFVGIPLGRSATPDEAAGAVVFLASPLASFVSGHTLEVTGGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC57</accession>
    <name>A0A2G8SC57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC57"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC57"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23810">
        <property type="entry name" value="UBCc_BIRC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="633"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="54"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="907"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="965" mass="104833" checksum="A356A38FD09B0734" modified="2018-01-31" version="1">MSSRKRRLSSEASPKTTKKPATAPDVLAVDDGDDDSLESILARIKAHEESEALAHKLHHEWNGPSSNSVSPSPSSVGTSSSTRAGIAASAPEDVIVISDGEPDADPVPEDDEAMARRLAKEWEIEDSPLSPRHPRPSTSAPNLAKRKAKRYPTPSIDVDDDATPAAHTNLPAIAKLEQCKDLFTDEKICSSCGAALPSPRGHVIFSQQPRAPPSLLRLLHAPCKACKTNHCRGCMAPVACPLTCKGEVAECAVETCCTNVRAIALYEALGGFDRQYLGEREVSDQRARDAAAKAQKNKTGSVGPGGTGYGMDSRYGISFSLQGGRGRGRGRGRGRASANASNGEQSRLDALAQHFDEIIVRALNTITGYLPAPYADNPQMYDILPHQSIDALLSVSQLPDLLGNLLRNDSVTDWITRIDVYHAVLGLLRRMADCELTLEVLVGQRWEMSKSCGIEEWMWGEGDITWERNKDTNAYIPTPPLYVHFKKLTRQCEAFLAGASNMLESGDDGDSDVTETTVKATSLCGDIIVARDDIERAMTVMGKNPAAILSGPRTSGSSSMSAPDEAPSSCKANGRDKGKGRDPAIDLERIYAAECERLAFEYVNLADASGRDYPTYKYGPELVRTANATRNPKDRLHLVKELAVMATSLPPGVWVRVDEVRNDAIKIMIAGPDGTPYAGGLFEFDCLIPLEYPHKPPLMHLRTTGGGSVRFNPNLYNCGKVCLSLLGTWPGRPEEQWSPKSTLLQVLVSIQSMILIDLPYFNEPGYGKANPNNGASIEYNKNICMQTTRWAIVEWLKDEHRDGIWGEVIASHFSTRHDVIRSRIHEWAKTQPNIRKYRSQGGGGGLYGGAGLFNTAIMAPPSLPGLIDTDMDMDFGIGLSVLEMPPPYYPGTSAAASANWGGGAPLFPPSSSSGGHALRSGKKKQESAAAAPTTPKTMDLLEEFDTWMKKVREWTFRDAEAIHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCF0</accession>
    <name>A0A2G8SCF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06141</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCF0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCF0"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="14"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="192" mass="20516" checksum="D90EB7CE47BA897D" modified="2018-01-31" version="1">MLLRTLTRPALVSRQLPRRLPPFARAMSVSHVDNASQLDGILNKSNTKLSVIDFHATWCGPCHMIAPTYEALAKQYPNVNFLKCDVDQAKDVAQRYRVTAMPTFVFLKGAAEVDRIRGANKPALEDALRRHSSGGAPSSGGFPGKGQTLAGGNSTAGTGAGGSGVAAFQALDPQVKVLLCLLGGYLLFWYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCG3</accession>
    <name>A0A2G8SCG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCG3"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF92">
        <property type="entry name" value="SPICHTHYIN, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="339"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="339"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="648" mass="69935" checksum="55EB889E9316D9C4" modified="2018-01-31" version="1">MSSDPSQPSQYRVVGVVLAIGSGVLIGSSFVFKKKGLLSSQKGHVAGEGVAYLKSPMWWTGMIIMILGELCNFGAYAFVEAIIVTPMGALSVVVSSILSHFFLKERLSLFGWISSIQCLLGASILALNGPEEQSVSTIEGFKHLFLAPWFLAYGGVVIAVAVFLAVWVAPRYGKRSMMPYLGVCSLIGGLSVSCTQGLGASIVTSIRGDNQFKNWFIYFLLGFVVVTLLTEIYYLNVALAMFNTAMVTPTYYVTFTFCTLVTSVILYQGLKASASQIITIVLAFAVICTGIIILQMTKIDPRQLANVDEHTTLLLEAAKQEADPLAAHEVELARGGTLRSRRSRFSQHVRSRTSEQEQLQEPTPTTTQSTNDIEAGPSHDSDSDIDFVDEKRAIIARTEEPGLDSLRMTGGAIGTIIRARRRATALSTASATRSRLSVSTNANSLHSHSQDAHVTASQRRSSLSPGPRPPWFQMFLGRRVEHSRSPHRTHSNLPDVSENEKPLDAMVEAAAAPISGLPQTLESPISLSTIDHSSSSPPNGQSPTQSRSGTREARFLGNGELVTSPLLTASPEEVTRRPSVRFEPGGRAVASAPDVRPPGTGSLSRPTITVQGEEDAAATRSRTMPSVFTAAERLRAEEILQEKPSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCX6</accession>
    <name>A0A2G8SCX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCX6"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="438" mass="48800" checksum="829DEA79E956FF75" modified="2018-01-31" version="1">MNPDPVQQQSQPPLFASSASTLSKNHSLHSSRLAPSTVKTYINTAPPWARDEPPSPKENEPADHSRFAHLTATSRPSDATSLQSSSQSGAPEDPGPSRWWAFTRHRPTDSGSIPLSPSLQRAPRRPRDGARSMSIPWLSVSVLRRSLDQDEEQTPSTLHDEAELDANDPELPAPPRMSNRSRLRIDMPPTAAPFTLAQNRTPGWETPWTSAHPNMSGSVAGSVRREQRDSHHDDEKLTSWQRRRKRLRAYMMYNVYVPLLFRLCNIVLTTAALAIAIRIRIIEQHAAVTGALGPSPTVVIIFASFTLVHVMIAIYLEYFGRPLGLWHTSWKLAYTLFEVVFICAWSSALALCFDNFFTSLIPCASASDISWYSQLPRPAAQNGVNGFEGGVGDTLCDDQVALICLVGVGLLMYCFNLFISLFRIFEKVKYHPALILNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDB5</accession>
    <name>A0A2G8SDB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDB5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDB5"/>
    <dbReference type="OrthoDB" id="73612at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000004">
        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08551">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="349" mass="37940" checksum="33E4D5A33801AC01" modified="2018-01-31" version="1">MAVLSLAPLQYVASIPPATRAFTAATVVFSLLYYFLLWTGDATFSAPYLVLIPGSSLFYPWTFLTSAFVESSIIELIFSLIVTPASLRYLERLWGSIETVKFVVVTIVASNIIAFVVNWLEYTVTKMPVFLYGQQYHGLMALQIGVLVGFTQIIPEHQVQIMGVFKARVKTLPMAYVTFSTVMCLIGFQVPFIIIQFGWLVSYVWLRFYKKNSAETLSGGPAYGDRSETFAFVSWFPPLLHGPMSILGNTVYGVANKFHLIPTGGNDAEAGGYSQVPGGARAEAERRRAMALKALDQRVAAVSPTPPRTANGSAPPRPGPSSAAPPAVVPAASSDGSSKDITENESESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDY8</accession>
    <name>A0A2G8SDY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDY8"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="443" mass="47940" checksum="B88CA624DB9CEEC4" modified="2018-01-31" version="1">MAPSALSPNVFHVLLQYISPPSQLTQPIPPHLLSKPLLQRHHFLHLTPEHPDDYLCWPSSPENKARVVDLLESRSRPLDDDQPSTFPVQYSFDGEYFFAHVDLSADSDQGPRIILQWDESGEWKYHNTDLMPFPPGSRVALEDVLVPPSPPNPASLQPFARPSYLHTFDVNDLHDDSDDDDYWNAYGVTDIGDSHHGQGAPATTKDAASSEDAYWAQYASVHGTADSTIPSPASRRKPLPGLQQLDGHKMESPLPLPVPVRVPDECEDPYAEPLPIPPGIIARNNTRWDPASPTTLAHLLSTISPRASPAASPAPDSRFNLDADLDEDLSSPTIGGSEDSDLSSWPALGLEGTDIEAVTIAEAARGSSAPAPCTIAETKAAVVVAVNGIDGDEDEADLRAALEGVWRMWKKTKGRAAGQCATSGDCEVREAFLRTAQLVADGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE34</accession>
    <name>A0A2G8SE34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE34"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE34"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="347"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL32011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="679" mass="73465" checksum="E4E4424E358583DB" modified="2018-01-31" version="1">MSVGAAIDSQPSSHLIDMDTEYDSSSEDGEYLWTAASRFQVPRCGKPSRTCKDSVRRSHNPSFRSRSAPPSSTPSLSPHPDRARTLPPLQGIMLAAPTVDLNFDNDDDWMPPPSSSPRLYRAASVGNSWGVTSIGRGCVWNNHNRGDESESDPEKPVQVTPDTTVTTSKDRSGLLCPTPPLWLNNSAVPRSAIANSVSMISATATSPAPLPPLSSPRSGNYVSGPLTRSPVQSRSSSPRPFPSRPPSPRPTSPMVTAALTPLSSTPSSPRSTQFPRMRRRSSQQRVSLLAGRVSITPVEPPSPLPAGPQKLVRTSSAASFLSVASSVGPPTPGQQTRSVDDRSISEFVIEREIGRGAYGLVKRAREMMDDGTLGPPLVIKQIIKSRILADCWKRHPKFGTIPIEIYVMSAISTTHYVLPPPRPWDPLRNKLAAKNDWMEGKVVSGHPNICPLLDFFEDNHYYYLVLPSTTPEPNLDEPSPPSDLFDLVETYPNGLPPDLIRTYLGQIADAVAFLHSKGIVHRDIKDENVVLGPAGKCVLIDFGSSGLVRKGGWDTFSGTLDYAGPEILRGERYFGKEQDVWAFGVVAYVMLVGECPFTTAAEAQDGLESPFANASIALDERCMEGKEKEGEEKDGGGALGDAAALVRACLRVDVDARPTFSKILQSRFLSGNGGWTSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE43</accession>
    <name>A0A2G8SE43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06552</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE43"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE43"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="212" mass="23770" checksum="F605BF68DFAA1AFC" modified="2018-01-31" version="1">MAPTKQAKQAPTRQAITLKGSTALVTEFFKFAANTILFQRGVYPADDFHMVKKYGQTVLVTQDLALENYLEKILKQVNQWLLTGSITQLVLAIISKDSRTPLERWVFDINLVEPPADSSEAAPAKPESEIQAEIRNILKQIVSTVTFLPVIDEPTVFNILAYTKESAEVPANEWVDTDPLAIEASKSQQVKLRSFSTDVHRIEAMVAYRYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF20</accession>
    <name>A0A2G8SF20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF20"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF20"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051966">
        <property type="entry name" value="RPAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46423:SF1">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="576" mass="64139" checksum="3C8B6693862D0F66" modified="2018-01-31" version="1">MPPKSSRPKKRLPNRKTATNAQNPGSHADHAHDHGNPSPHADQSISQPSVADLERVISRILLLRYEQDLARLFSTHLYHISLVHIPTLVLQCVTVGGPSWVAVNADCDDIKNFFRGAIAMDFRQAGDRIATKSVLWTYTALRHFAKSNGIPICERRGLHSWQLLPYYDALQAHLDSLEAQHRPRFVKPPLLGPPTDALNKLAEAARASKKAKDREWKARVREGYDRACSTMWRVAQEFDVRGYGLVLRQKLVEKWCKCGCSTDHLGEVCEPTVRADEEESGVRAGKEREWDGRGAGVDGWGTEEEEDLWTVDVNVNLHDAQIERDPEAADDDRMTAGELTEWRYMCSEREKEKGNLAFKKGDYAHAIKHYNDAYRIEPELPHYQLNLAAAYLKANNFVEAEHACDVALGQHSSVKGHWRRAQSRKAQGRVDDALKDLREVLRLQPANAEALAEIRALCPTEPLASDEAIASCSSSSAAFSPSGTASSSYSSWIPTPEPPAPLPFAPIETDSRKLKISFLPITVDIPAHFPEEAASAGMRMSKLPGSCSAGIAPGPTGQHTFQYAAWERYMVQRMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF21</accession>
    <name>A0A2G8SF21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF21"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF21"/>
    <dbReference type="OrthoDB" id="2538110at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="122" mass="14262" checksum="041DC676749216CC" modified="2018-01-31" version="1">MPADEYQYERIPTTDEKRKFPREEPTSDVRELHRRLAQDPRFNPPTPSPWKRIALIVFLISLLYLGLKLRLNAIQKLETEPSVVHANRYSKDFKYRPAASPIITERLKDGRTRLRGAVPTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFL7</accession>
    <name>A0A2G8SFL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFL7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFL7"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="74" mass="8356" checksum="653BBC330268190D" modified="2018-01-31" version="1">MSASLTRTYRYLQRQAHEQPVIFFSVVIGLIGPAMVVTVPSIRKSLGWKPSEPIPTSYPVPNRPRRPVSGYEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFS5</accession>
    <name>A0A2G8SFS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_05250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFS5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFS5"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="17"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="383"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL32547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="528" mass="59828" checksum="99D9140FF6607FD4" modified="2018-01-31" version="1">MSSMQHLGKGIVRAAKNYTKGYSDVQAKVRDATSNDPWGPSGTQMNDLAQMSYNQDHFVEIMEMLDKRLNDKGKNWRHVFKSLTVLDYLLHAGSENVVVYFRDNIYIIKTLKEFQYIDEEGKDQGANVRQKAKDITNLLQDESRLRRERRDRASMRDRMVRGRRDGEPGADDDGTEGNENDRRRSRSVPGNGRRRGGPGAGGNREDDDLRRALEESKRTAAEEIQRQRLTAEERDLQQAIRLSEEEEAKRNQALADANASSLFDEGQQQQAAQQSTNPFPLVDTSLQAAQPQFLQPQFTAVPQQFTSFNPYQQQAQQEAMQAEYMRQQQEWQMQQQLQAQQLQQQQQQEEWMRQQQLLQLQQQQQQQQFLMPQQQPLMPQATGFGSNNPFAPSLAVSTSMQQHSSSPGPQTSSPVSFNLQGTYGNGPTSVSPPPLSHSAPPSAQRQNTMPMVKTRADDEHSKLANLLAAREDGIDTFGNWGNLRYGQQAGRLAGQLTGAPHNSHNPFTLQQQQQQQQGIANEQPFFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGU0</accession>
    <name>A0A2G8SGU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGU0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGU0"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17934">
        <property type="entry name" value="DEXXQc_Upf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF16">
        <property type="entry name" value="HELICASE WITH ZINC FINGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13604">
        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="6">
        <location>
            <begin position="539"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="752" mass="82369" checksum="EE8D74A0931C37DF" modified="2018-01-31" version="1">MPTFTQKVAPGLPADVPVQRLKADSCLALLDRLGLSSHTDIDNDNPIPVAVSFRLTKGGFIEAIALAADTTVFQVTVTKNVSHSDLASVLSHPRCLFVAVDMARVALLLHRQFGMHIRGVDLATLPCPSIPGSKKQHPAVRLAHALLPKPIHGQGVCALFYRSTNKDLCLRAWLSAWCVSVESSGHRQQKPPGRDHAGAQSRPRNLSGPELACLSQLVLNVELLDAERPTRMDNDFERVEVDKTGSTIVTNARFKSKVRESGQTVVHINGGKVKALATGAKGKETTLRLLGKGKLPEKVTKGLEAMDESPFVKMLWFPPSKDKGRHRKRGKTNANVAEDVQITTTLFQKLNPSQQAVVRAVVGDKEPLVIAHGPPGTGKTSTIAVALDHWGKHRKPAWVIAHSNVGVKNIAESLVKRKIDFKIVVSQDFYYEWHEHHYVDISDHLIQSDKLLHKSTDINVLFGKTKIILCTLSMLSSPAMDMCGVFQRVPVERLVVDEASQIDTFEFMVCMFGDPNQLPPYGKETAPKMKTIFDFAQFRASSYFLDTQYRMPVPLGDFISKHVYDSRLKSSHAITAPNCVKFVDVRKGAEAPAGSSWKNMDEVHTVVNLVKRYYKDERKVCIITPYDGQRAALVSALKTAGLPHGNVYNVDSYQGHEAPLVIVSVVRTSAPGFLKSLNRMNVMLTRCQAGMVIVTNRAFLCGPAQKTLLGKLADHWGSLAAGARPAGDSPESAAWVDAMRVAEGTARLPGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH30</accession>
    <name>A0A2G8SH30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH30"/>
    <dbReference type="STRING" id="1077348.A0A2G8SH30"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="159" mass="18305" checksum="C9053DAF3EF4D2F1" modified="2018-01-31" version="1">MFPPRRSQLSLHGRHNTVDISCISSILRLGDKYHLAPSLLMEAKNHLMTYYTTSFEAWADRCNALRWQPQPLDAIRVINLSRLLDIPSVLPTAFYICANIDPEELRYGSTLEDGSIRETLTPEDQFLVAQMRSCLVAENANNTFILFQAPRARIWPWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI67</accession>
    <name>A0A2G8SI67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI67"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI67"/>
    <dbReference type="OrthoDB" id="10067381at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="387" mass="42004" checksum="5FD9EE4AE9FB3BAE" modified="2018-01-31" version="1">MSKKDDDIVPADYQYEWSPKSEGTLQDFLGKCKPSMVQNDGTKPWLWVGKAERPEKLEGADAAVKEAAECLAAVTERVEEIQNDDSIPVRANKKKGLRSKKELREEVQTEATQKLKDIAVKHGYVSGKWLIFAPPDKVDMIWSSLANSLVSGPLSSTSAFLAKVATSPQDDTPNYSHLICVYMPDAYDQSSVLEVMKVLLRNHGMNLMGVKTNLYTSIGLDSKHPSGVSSTVWKNTALMKDSEIKALREEYFSELNATKSAAAEAAAAKKAEGGAATKGKSKPKPKKKAGAEDPFASDDDESKEEEKKPSSKAAAKPASKGKKPALKKKVPADDFASDEDDEDGEAARKAEVKAKKAASAPTTRKRKESESDAESVEAAPKKKRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI68</accession>
    <name>A0A2G8SI68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI68"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI68"/>
    <dbReference type="OrthoDB" id="2755983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="369" mass="42098" checksum="BA72E05741319ABA" modified="2018-01-31" version="1">MRCYGDSDPQDSWQPVEMTSLSARPGPDTCILIREMDRRRALRLRCQGPRIALRYLGAGPRTFQLTRRIYVRSRSISLTRVAKRGLFCIKRDQARTGPVCDISHDRLAQTSWKQKFEARKLRSPPSCSHPDSTSSLSLSPRTSLRLRQSMTGFRAVGDTLGPNYARREGELKGGTRQSMDATVASMSGIPGRKMRWTLKLYFKYVYLALRIKLVGWPHDIPFMNLSDITGLVRISRIASLWESGRMYFAPVTDEEYLAALADPLSCAPAPLHHGFAPDLGRCDIKKRKYRPKTDPLNLRQGRYIRNGPKSARWVSQMAERRAEGRELLADQIGSFSEDEGPSRRTTSGRRARRQEIRGVELEEDPIEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI92</accession>
    <name>A0A2G8SI92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI92"/>
    <dbReference type="OrthoDB" id="2756427at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="531" mass="58070" checksum="378FB0C8B5606D7E" modified="2018-01-31" version="1">MTPNHPTSSLSFKDCHMTPKGIGAMAEHLRSLPFFQAVPEPRVRAVAIALIAFGGSLDGLHRVCESHYPAPDAYAENVRTNRPPGLLDEYMRLIMDLLTWYDRISGGASFLVSTPANHPGNPPTITEVNMDVFLPTILQEQPRTGIVFARMVQYFAEEIGLPAVQRAHKAKPTKHQRLPIGAASAASPGDIQPLIPPSETPWHKFYGRDSGVLERLIAEQASGLGIVPKMPSTISRTLPSSQAPSPEGVAPRTTVLHQGAARTVGDIGRFVRQFERCNENDEAGRRAIMEQVSTRLPDVFNVILDLERRVKTLETINETQLVEIWSLQQALEESADQRNEELMRINTELSSASRLSLPSSGVAGTGSASVAEPSISELPRPLLPLDKSESRLAHVKHSSRTVTSSSMTLPNSSISYFAPRKSMPVHASAPPHASTPNSSTRQSSPNASPSPSQAVPHNLGLSKGRIFGPNTEQVLIHHQLPRRTHTLLRYVEMNFQGNWMEGVHTMVPNCSQDLARELVVAMEADCRLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIQ2</accession>
    <name>A0A2G8SIQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIQ2"/>
    <dbReference type="OrthoDB" id="2736021at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="228" mass="25431" checksum="779CEA59124E28B3" modified="2018-01-31" version="1">MSRAGPYTPWLFTTMPEPLVSLTQSKPIIICPLETFKSIYLFRNLRFGPIDRDGSEKRHICCVCEDSPPALIRPKTPILFDVLGQIAVEDCFLTARGCPRPANEEPVASCWLQQRPNIVSDLKWRGIIPVIEAIVEEYAVGSEVDTSRLLTVGPDGKLRLQVIWHGEVGEFGLQLPIFDELGTEQVPESISQVPFGVPVHAVFSIEFVHDRRAGTRTVFASLFAMLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIZ9</accession>
    <name>A0A2G8SIZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIZ9"/>
    <dbReference type="OrthoDB" id="2758729at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="223" mass="24326" checksum="C8A92E940930B58D" modified="2018-01-31" version="1">MRMLSSRPAGTGGSVRSISWTVTGPLDDSIPQFPRSQSSCFEVPASPPSPQPSSSHVHIPVSVLPASRSTMVDWSDIWNITSGVLSLAPCFFGYLYHQLPSYLFRLLDGTLKETESLLGSSMEDGLITDSSLTLKYMQSAEQLRTRAERMRPLVYRATTYWLELRSIFDGLSREISKLSAEVLGLRAEVCAAISSSRERLRDEAELAPSEGGAGTVADAHVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ23</accession>
    <name>A0A2G8SJ23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ23"/>
    <dbReference type="OrthoDB" id="10472341at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="14953" checksum="2B5927864EDA9AC9" modified="2018-01-31" version="1">MSRAQVPKEARMYRKKLFAGGRMPTHDEKWRVYEDMVNIYGCTGYTRRQHSNWCTDLERNRLKSPRPLIAARLQVTPNPTAVEVARWALELNIADVDAFRLVGALLPEGVKAQAHFEHSLHHTQFALGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ31</accession>
    <name>A0A2G8SJ31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_04397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ31"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ31"/>
    <dbReference type="OrthoDB" id="416777at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="444" mass="50147" checksum="8B05E218AD5F010F" modified="2018-01-31" version="1">MAIPLAPPEHPAIDVAELKKVNTYAQPAAFPEHFPEGVNPALETSKWAQEELDIVSLNDEGIQSAAQYIHYQMRHEAYFPRTWRTHPLHICPTDPFSWDDPSTIACLNWIFFISSLNFSFWSELEGQSGRYGVEWRDAWSSETRVVHTGYWSLVAAVNRALEEGIQLTDPAFFASEARCPDSLIEYVFRPAGQSVEAIPLIRERIVVLRQVGSILCQDFGGSFYGFIQAFRLRYNNRGTALQLVKMVTEIFPSFRDEHMLNGRRGKSSPIHSLTPPSLDPSFPAVYVWKRAQILVAETWAAFYPEISSAPHPLFPAGPAIHELTMFADYRVPQILHHLRMLTYPSALIELLEARTPLASGSREELSVRAASIVAVERVRREIARLIADEEGGDGGRACSDAVSSVMIDFYLWDLAKRVEGRERGVEGVETCAMLPVHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ88</accession>
    <name>A0A2G8SJ88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ88"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ88"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04701">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF43">
        <property type="entry name" value="ASPARAGINASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL33832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="40501" checksum="870B0A0084B69C12" modified="2018-01-31" version="1">MSILEKAPLLADNEALGSSLPGRKTAAKFRLVIHGGAGTMDKSRSTPELRAQYKAALSRALLAGYAVLETGGEAMDAAVAAVSSMEDCPLFNSGKGAVFNIAGKNELETSLMVSRPPSTHPSIPSTRRGVGITLLTHTRNPSKLARALYLAPDTAPHTMFSGTAAEDLGAPFGIELVDESYFFTEQRWREHRRGLGLPDEPLPYPTKPAPGDGQTQVPLDQLPTGTVGAVALDVRGCIASVTSTGGRTNKLVGRVGDTPSMGSGFWAEEWAVKGWSRRAWLRIQGKSTTVAMGVSGTGDGDYFIRLATASTIGRRMKYLHESVAVAAKACVEDLRRDGGVGGVIALDSAGNVAMPMNCSGMYRGVVYEDGVPKTAIFDDDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK10</accession>
    <name>A0A2G8SK10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_03822</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK10"/>
    <dbReference type="OrthoDB" id="77201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013621010" description="glucan endo-1,3-beta-D-glucosidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL34111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="359" mass="39627" checksum="1250E980D617FAFA" modified="2018-01-31" version="1">MVLSTLLGALALSLLASAAPLEKGVQPHNFRASTPAARSDATTDANPAPFCFPSLGFIPSSALPSDNTNWWCDPATEYAFLGFSYEVTACQSKAQLQKEFSDIRYHFDSRYVRLYGACDRDGFYDDIVEAAWDNQLGVHALVWFGFDGSDIWKTRRDTLFGALHANPKAKFVTRVVQFGSEPLFDDVLPHAQLAQQVTLAKQNLSSLHIPVTVSELAYGYQERGGAQDVLNAIDSINIHMLPFFAQTASTSDKAWPLVENDLNWFIKHGNGKKMYFDENGWPSVTSEGVQPNSPDAVADIPNEQGYYELLDQHCTDLKAVVGGGIGWFAHIYSDDQEPGYGIYNSDGVLKFPFSPRTSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKI4</accession>
    <name>A0A2G8SKI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKI4"/>
    <dbReference type="OrthoDB" id="2756799at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="510" mass="56084" checksum="00B828D71D2F4BDD" modified="2018-01-31" version="1">MPRPEASTARKRGRTASCSPLRGTASLLVLLELDSTLPCADDNTDSVGGRTVTEAQTRDFVAIERRAPCQPKNSTAAPSKVTSEFDEDECLVDLNLSSSLSDVTLYDVVEADDSEGFSVGVEIEEASETQKRMSVYHKEPVPVSRHVHHISTVPSIDTEYSSVSHFHTATSSSCSTATTSTTDSKRRALPWRLYEDLSSAALELHLFPSPFHPQPLVPLLCVGDEQNIVPLMCSTLHQCRALGRADVPVVGILLPGSGSTCEVLFGWIEKGPRPGRTLAKIHICARGLSSRIPTVFDLERPYSALCLVRFLAGLGAQAEQLRVGSQREAGSRDRASLGQGWRADTHFRAGFRASCDESEARIRLWTYEVGCCNQVQEEDDFTAGEGHEIIPRASQSSRMHQRYSDNEQLVKLLRQNVADLFVVGLSKATRRSRSPVSTRENRKTPCERSTNTQSVSGMKDNIRGERRQAGGTAKDDSRVVSWCSSCSDGSDDWDTDALWQRAYNALAFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLC8</accession>
    <name>A0A2G8SLC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_03339</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLC8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLC8"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013681438" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL34561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="414" mass="44759" checksum="F3E79C64F211D2EF" modified="2018-01-31" version="1">MRFALIAFAATFLSTIGGAVAVEEGKGPSKVCTLRPLGGGLDDTDQVEAAIAKCGHFGTTIFGPGEYNITRKMTWDLVSSRVDLHGYLSFKPDIEYWLNASNTYRVIFLQNQASWFVVTGHDFVIDAHASGGINGNGQPWWSYFATRVREDGDGRPIAFTLSNVTRAVVRDFRIEAQPFWCNIVADSSEVTYDGMYCNATNQDPTYAGINIVPNTDGFDSYRSDKITLLRWDNSTNISVKDAICRGGNGIAFGSVGQYVQFNDIIDNVYMENLKIIRQDLQIQPNHHQGVYFKSWPGSVDGVPPVGGGGAGGYVSNVVTKNVTLEGVIVPVHLYQTNGGHAGDAPSKLQFSNLSFVDWTGFSEGSNQCSSAAPCPGMNFENFNIAVENGATPTYTCINVVSETGLPGCEVIGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLR0</accession>
    <name>A0A2G8SLR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLR0"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="147" mass="15330" checksum="01891524DE701C59" modified="2018-01-31" version="1">MPDDMNGGPWRAASFYHEACVAPIVAIYPMVIVVLVALNQSQLEHGLACTQGPARSVSTWAVASCSYPHTAGTSTRVLTLTHASGLGGGPFSSGATREAQTDGLDIADSVETRTSVDSGPFAGQLKLEGDRAREREQDADEKAAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNE2</accession>
    <name>A0A2G8SNE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNE2"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="23267" checksum="002458412743CA2B" modified="2018-01-31" version="1">MEEGDVVASFGPRWAPLRRLVLASPNMAVCVVDRLSAVRLLQVSGMLGFDDTPEDGHPVFQFLELLRVASPIGLYASLRIERGGFSGPFWKDVRACAPRLRSLELKLSYSAVRGNGDGDDWLNPIRMADESDSAAVIAALNAVLAGDYMDVTTMVVVVYDYLITFGVEVDLFWRKEITGASIVFFLNRYLILAYNLIRLPTWFPLSGSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNF0</accession>
    <name>A0A2G8SNF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNF0"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="211" mass="21172" checksum="B217243279CB5A2B" modified="2018-01-31" version="1">MPGSSLSPPPATGRHQAVPPRPPQSPPNSSVHHNNHPASNGNGRSVHPPPQRPPPPQHPPPTRFSWSSSLLTMLTTLGCFAVLCASASAASTRFALHAAAPVYALYPPLVAAMLVGGCCALVCYAPTMLAVLVFHALFGTDIRTRRAAPPGQGRVVGEEGAGAGTGTGAGTGAGMGWSVLRDGASTIKLALVVAPVYVMALGRGLGGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNJ0</accession>
    <name>A0A2G8SNJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNJ0"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="451" mass="50953" checksum="AF9D9510C26BC1CA" modified="2018-01-31" version="1">MLITRIRPSIWIPAMEVIWSVLTMVLASAKNFETLIVVRFLVGLAESTFYPAIQYVIGSWYKPDELGKRACIFHTASALGPMFSGFLQTGAYNGLNGVHGLAGWKWLFVIDGIITVPIALLGFLIMPDLPSNTKPSIFYTQEQIDIGRRRMAEIGRKPPAAFTRKKIAGFFTTWHIYTLVPLYVLFNNGGGSSNSMIFWYLYPTHPFSASRDAKTLILFRLKSFNKPRHTVYTIGQINTYPLGIQAVQVVTTLIYAWWSDIVRARWPPMLLAGTWAMTTNIVLASTPLYEHITRRWVFYYFTLVQGGLSGLILAWANELTGHDNEKRAFVVASCNMFAYVVQAWLPILIFPQVEQPRVFKGNVTTACINFSMMCFAMLTLYLSKRDQRRERKLRASTVPSESSDDYVAEDETHMDIKEANVKTQARASETDVSEVPVPTLTSEFRCAASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNU5</accession>
    <name>A0A2G8SNU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNU5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNU5"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836174" description="Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="229"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="567"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="71345" checksum="88BF8C2082C48E0B" modified="2018-01-31" version="1">MLPSLSLLLFAVGAAAAVPYQEYILAPSSRTIRPTAVYLRSGSVSSEAALLDSGVSSGGRLTLGAFNSSVTYDFGKNIAGWVNFNTTSDGGSLGVTFSESSLWVSSEACDGTRGIILDAPMVFNITGAGHYAAPTIMERGAFRYLTLVNRGLDSLSIDDLWVHFTAMPHWADDSLQNYTGWFNSNDEKLNRVWYAGAYTLQMVTMDPTRGNAVFYSNATNPDGFYLWWLNTTVANGTSMLTDGAKRDRLAWSADLSVSVPGVAVTTFDLVSARNAFDDIFDFQSADGMLPYGGFPVSLGNAASFTYHVYALIGVWNVYRWSGDQSYIDEKWVQWKAGMEWAVAQIDNTGLANITATFDWLRFGMGGHNIEANTLLFYTLSLGVALARNQNDSTAADRWSQLAAGVQSAAIDLLWQPDVGLFKDNETTTLAPQDGNTWAVKSGLVTNASQVAQISEALQARWGPYGAPAPEAADAISPFISGFELETHFMANRTTAALTLIRNMWADFMLDDPRMTNSTFIEGYSTTGELHYAPYPSISHAHGWSIGPTSSLTTYVGGIQLLSGAGATWAIVPQVGDLTRVDAGFSTSLGGFSSKWSTNGTVFRLEISTPEGTTGIVGLPLPGNHTSATLTGTDLEGVTVTVDESGRYWIEDSAGGDLEITVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRN2</accession>
    <name>A0A2G8SRN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="4">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="4">MTA phosphorylase</shortName>
            <shortName evidence="4">MTAP</shortName>
            <shortName evidence="4">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_00090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRN2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRN2"/>
    <dbReference type="OrthoDB" id="431409at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679:SF2">
        <property type="entry name" value="S-METHYL-5'-THIOADENOSINE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 4" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="59"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="92"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="4">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL36402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="314" mass="33650" checksum="9DD18F7EF0FD64B2" modified="2018-01-31" version="1">MGADNENVLVGVIGGSGLYHLDNLTLLKTVNPETPWGFPSSPIAICVLPSGTKVAFLARHGAGHAIPPSAVPARANIAALKALGVRAILAFSAVGSLREELAPGDFVLPDQIIDRTKGVRPASFFEGTSVVAHAAFGDPFSGKLIAWLEERARRVVEAAEEGGADPARTTKPKLHTGKTIVCMEGPQFSTRAESRMYRQWGGDIINMSVLPEAKLAREAELGYALMATVTDYDSWREGESAVTAAEVFKTLHANAALSRQVAATVLEELNGAAAHGDLLTEEIGSMQYSIMPRSEQQKPEDRQKLAYILPNYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRR0</accession>
    <name>A0A2G8SRR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRR0"/>
    <dbReference type="OrthoDB" id="2339190at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013580552" evidence="2">
        <location>
            <begin position="27"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="246" mass="27214" checksum="D50721DC11C371F6" modified="2018-01-31" version="1">MFTKTTLAKCALAAAAALSTLTSVSASPAPTALQARGDTYAPSSTSYWPQKTGDYGHDDCDCDFGWDKDHVPKITQPNKDTVWKVGTQQKVTWEVKWDDKKNGGDDGKGWQDGKYRRDGKDGKDWDDGKKCQEWGGDDGKDGKREGCKARLFLRKGDELPFLILAEGFDVKSGSADVTVPNVFFGSDYRVTLSIRDDKPELQSNSEKFKIVKDGEDGKDYDNFCKDGKDKDGKDCKDWNDGKSGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRZ7</accession>
    <name>A0A2G8SRZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00234</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRZ7"/>
    <dbReference type="OrthoDB" id="3002517at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="86" mass="9963" checksum="BD858AB49BF88E90" modified="2018-01-31" version="1">MEVLVWDAIQLVINGPSSEVRIYGRPFRSDDPNWTYFDDALTELEEDLICGMYLVQTTTYQKGFMVSNTKRLGIRKSVARTMEHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSA6</accession>
    <name>A0A2G8SSA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Formate dehydrogenase</fullName>
            <shortName evidence="5">FDH</shortName>
            <ecNumber evidence="2 5">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 5"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSA6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSA6"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="7">
        <location>
            <begin position="60"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="8">
        <location>
            <begin position="153"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="254"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="335"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="5">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="384" mass="41554" checksum="BC869A181BF440AD" modified="2018-01-31" version="1">MSLLGASTAALKRGLASSVSRTSSRGLKVLAVLYQGGEAAKQEPRLLGTIENQLGLRPWLESQGHELIATDDKEGPNSVFQKHLKDAEILITTPFHPGYLTRDLISKAQNLKLCVTAGVGSDHIDLNAAVEKKIQVLEVTGSNVVSVAEHVVMSILLLVRNFVPAHEMIERGDWQVSDVARNAFDLEGKVIGTIGAGRIGYRVLERLVPFNPKELLYYDYNALPAEGAAKVGVRRIEDLKDFVSQCDVITVNAPLHEGTKNLVDADLLSHFKKGAWLVNTARGAICNAEDVAAALASGRLAGYAGDVWNVQPAPRDHPWRYMKNPLGGGNGMTPHYSGTTLDAQARYAAGTREIIENYLAGKPQNPANVIVGVGKYETKSYGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSZ7</accession>
    <name>A0A2G8SSZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSZ7"/>
    <dbReference type="OrthoDB" id="3263739at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="606" mass="69228" checksum="4AE9FD47BBA8CC23" modified="2018-01-31" version="1">MPELDILHGLEFQIKRVVSDWEERFPIPFDARPIIFPRCFAVGTLNKPYTTCTVDHRPPFADPTALGLAPGIHSVNDADVRRAEGQPFHSLLGSVPGGRLFVRARGKELVVAAGQYAFRFHFGLEGIVAIVDTPSFWELVSKDCPGKNKDGEKSEIMRSFIVPPALTTPAARQLKQEQTINIFAAFVGPKDTFIFTDHSRLLRMHVMVLTRSFLERDLEPESELWPFLWSTNHGPDWIFERGAAEQALDAWRDSVIGSKASLRDCMDSFLRRQNTEDNIMRLKATATRRSKAPHVVACAHRPIPMTKTIIHVLTERQDIFNGYGQHTASDILYDLRIWPGMPAEHVCKDNKLFQSLKIRLHTYAAQFVSDRYRELCLSVPNGPAFAFNYKSDTNYINQYLSVYRKCFVRIRREQYNAMAREGLFNSEHMIGARYHCEDDELIDVNYRDVPVFVYRLVEEDKGDKKKKEVLWYSPIRAKRPSHWRSLPGPFLATDNVLHAGMKTTIGPASFYLFKLNQYDPEAHGKPGRRKKITNGRRGRPAHEPRIGDLRRRDARKRKELAATSVLITSQAKSQMKRRKIASRSAPVPPSDRVTRSRACRTGGTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STG6</accession>
    <name>A0A2G8STG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STG6"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="657" mass="72697" checksum="E6007AA8AC53B358" modified="2018-01-31" version="1">MTFPANVDADPDPTSQIAWPGRQGGRGRRASKHLQDTRSASGSRPSMSRVNGGAVSKSPMAEATGQKGRMSTLDLFNLSIAMGGSQVAWTVELGYGTPFLLDLGLSEQLTSLVWLAGPISGLIAQPVIGAISDASTSKYRRRYWIVTSTFVLVISTLTIAYCREIASFFVDVVGGGAGSWDPKYSKTVQNTAIGFAIVSFYLLDFALNALQASLRNLLLDVTPPEQLNAANAWHSRMLNAGNIVGFGFGFLPLANLPILRLLGGSQFRKFCVVCMIILSGTVWITCWTQEEKEREQRRVEKSASMRDILSNIWNTILTLPKPIRRVCYVQTFAFMGWFPFLFYSTTYIGQVMAYELGKEPDHDLATRTGAFAMLIYSLVAVAAGTLLPMLTRREDALLMHGDEDEDSELTRLREQVHEWRAQAARQDKPLRLPIMPFFLRNIWTGALLLFTCLSLATFFVTRVWQAIIIVSLVGICWAVACWAPFAIIMEFLKERESEVQEDGEAIAREWAHRPSHSRTLSTPAAGRDSRHVLDDERTPLVRRRSLEHRNADSVPFETETAAGGTILGIHNLAIVMPQFVVAIASSVIFSIVDPSDGEPTHDTALYGKNGVAWVLRFGGICTLLGALLARRVPPTHTEKQMRKRLAELKVLQEEGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUB4</accession>
    <name>A0A2G8SUB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUB4"/>
    <dbReference type="OrthoDB" id="2989199at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="318" mass="33864" checksum="EB9D2922E9E66BE7" modified="2018-01-31" version="1">MNLGHIVNPGDAGGIQTAISVSPLTSMLADERPDAPRPRGASHKGERSGLFLASNTGPKSRPAESRQGKSTAPKRKARRRTSNTQRRVRGGAASDAIPIRDSFSRDTAIRSCHLRHGQPPSSAGDPPLAPHVAARHRQAGCSWSATLPPSSPAMDLPRRMQVAPSPATAWLGRRPCIVSDSSTILTGPGPAAQDHSQDAIREAIERSQAALGPVHAQRRFESVSDLEDGRSFELYWEAQMARSRLAAGEGDASPSPRMQGVRLVHGFQVSAERLTACWPGDEGTDSPPSNQGSSPSMGTPQHMNVNVGTMEPTDRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUF6</accession>
    <name>A0A2G8SUF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUF6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUF6"/>
    <dbReference type="OrthoDB" id="3253137at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="455" mass="48717" checksum="11FBB7D366FB5991" modified="2018-01-31" version="1">MGKWTLEYHDEVLRNKVKNLVQGTIKRMKVEKEGPSITYESFVEELDEGDAFTTTLIDVLVKELAERKQRPNPVDRRLISEKTAKSLRMQAAPLHIYRGSQGSLRDRARRSVPLPPPRPYSATFHDILSDSDGDEEYGTMLGSSGQVEGAQINTDLYDAYLPSTYDLPGSISRSTERNAGSPHPPEPTGSWLMHSPPRSPSTGFGTTGWMGLGGPGSSSLTRQPTVRRPHRSRTIDSSTEFSGFTSRRRTAMRNSATLDDVPRESSGDAVGRSSSIDASRPTESSTAGDIGSRGSLDLSAWMARRRAGASSLGNVSVDELGWPSTSSNPSSSQMWYSMTTSSSASPEPMSLAALSRRSSTTDLNDDRRQSIAPRLRRGGLRPPESLLLHGPASPGDGSSLHSTSTTPSHAPVQVITAQSPPSEQPGAVAESSTPPAGSSVPPSTSGSATPAVESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV64</accession>
    <name>A0A2G8SV64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01344</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV64"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV64"/>
    <dbReference type="OrthoDB" id="2739885at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="25378" checksum="885394C96CAA3B7E" modified="2018-01-31" version="1">MFIYNGKFNWLDYASDETITVVFPSGFTLNDPVSAYWQWSEDAQGHKKADVANSGVIQSITTAAGGEYRRIHFSFGYDTFDAEVTADRKTLFLTMRNPSGSVAGPTDLAAMHVNPARVRSATVYTGRLEWYSYAKNELTTLVVPYGVAEGAFFGLYHQWTVDAAGVEKANHPVNGVFQDVEYHADGTTTAKFSASYYTYSFTFNGKGGSLVLANPRGGISEGNKFVVAYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVB2</accession>
    <name>A0A2G8SVB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Terpene synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVB2"/>
    <dbReference type="OrthoDB" id="2800002at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="68" mass="8027" checksum="0C77A1E7A26CFC1D" modified="2018-01-31" version="1">MSDWPWPRKLNPLYEEVEAESIAWLESFKPYTQDSQRAHNQGDFGRLAALVWSDAPRDRLRIANDFMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLH5</accession>
    <name>A0A2G8RLH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLH5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLH5"/>
    <dbReference type="OrthoDB" id="2278929at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="441" mass="46495" checksum="1EBEBB274C533179" modified="2018-01-31" version="1">MSASSSRHAPSLPLPTTPPVQVQHGVKRRRPRNSPFVHEARDTNIADQAAIDEAATRCQLESANDVISCFPNTSTVFAQDEWATFVWNSRLPQWAQTNLVNIYLFQADSGDPVANQTNVTNPSGRAGQVHFQINDTWWGPRGSNWDGHNQSFPFYFLITRNDKSISNTDIPQATFTAVQTTFASSVLASMSSASVASASSASAASVSAASASATLTSLTPTATPSPGSPTDSRNGSSATGAVQADGGSSSFPKWAIAVIVVLGFLALVAFGILAFYITRRLRQRRSGTLSHRNSMGSSTPMMSNVERGGPTSPVLGPAALVGAGAAGGTYSDRPPSPGGGHDGASMISRTSDTGPFSGADAAIMANAFRQALRKPDFADTPVEDPDEMIAQAHQSRTELLNQELAEEGRDIRSVGSSRGVRVETLSSEDGNDTATVQDHMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLI5</accession>
    <name>A0A2G8RLI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLI5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLI5"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15273" checksum="E8E22FB73D51E983" modified="2018-01-31" version="1">MTTTTEYSLPAYVYKILSTAPPSSIPAALPLSDLDRRDGFIHLSNASQIPITASLFFTSNTELWLLKLDTRKTIEAGGVYRWNKELPGCPHLYSHTDGEWIDLGSENVVSSASVARPEGQTWEDAFLGLKESGWLVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLW7</accession>
    <name>A0A2G8RLW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_15198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLW7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLW7"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13314">
        <property type="entry name" value="PH_Rpn13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.70:FF:000001">
        <property type="entry name" value="Proteasomal ubiquitin receptor ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="8">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DEUBAD" evidence="7">
        <location>
            <begin position="182"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL22509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="300" mass="32551" checksum="6A1BE42CE63BD9FA" modified="2018-01-31" version="1">MAETRLAFKAGRAFRRGNTNFVDSDPTKGAILLQNGEDGLLHFIWKNRTNNDAEEDLILFPGDATFQKVEQSAWGRTYVLKFSSSNQRHFFWMQDADGSRDEEFVGNVNRLLADPSIVPIWYSAGYNPNNQASTSSAPAASSSTPAASQRPGDYQPTPEELARIRSIVTSLGTNAGAGLAASSAAQHEISLTDVLTPANLRPLFASHPELVQSLFPHLPPDLPHPPTAETLQQVVASPQFRAAVRNLDMALRTGLLGELVRTLGLPAEAGTGVEPFLRALQDQARREENGEGSGDQMDTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM66</accession>
    <name>A0A2G8RM66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_15296</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM66"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM66"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL22606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="429" mass="47812" checksum="BAE5A4DA944F1939" modified="2018-01-31" version="1">MYRGALRIPSTSLKTSASYSTAARSSLCYLRPSTSSRPRHFSTPAHPSEDKKISSTSPDEKPLLPEADEDAAHSTAEPITLSSSPPSFDSSTSSNPADPVRNTSADQFNSFKERMQELTTDTLKQMRVRGDEFTTRVAKTFSKLGAELNRVTGYEEIEILKRKVVEQEGRILAEREAARAAKEAYENAVLQRSKSQREVNDLLQRKSQWTDEDVLRFTTLVREDHTREHEEARAKNAAHAAEDAVEREFGELMRVILSRYHEEQAWSDKIRSAATYGQLAALALNLAVFVLAIVLVEPWKRRRLAQTFERKVEEMGARTELAFEERTSELKGRLDEQAKALATLLETVHLANQVDVSEILAIERSLGQGRGAGGEEEEGGARTPPPYPHEERIPGVLPKPRTDGELVFVVTASAAAAGLLGWLARSWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM94</accession>
    <name>A0A2G8RM94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM94"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM94"/>
    <dbReference type="OrthoDB" id="3227715at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.70">
        <property type="entry name" value="Designed single chain three-helix bundle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="198" mass="21804" checksum="90EAEEA8C1CF49E7" modified="2018-01-31" version="1">MPNQPYIVHPTDMQYVPTIMRAPSPSSTIGTDYGPDETTIVDSELSEHDFVRKCEEIVGINRPRPEEDEANRDPLVLPRPWSRQKLTLLEERQMFEQVMSNLRAAVKRLEEDELFEQTAVKRADAVLDDPNATSDDVDTIMQSLMGLSASSGPNAAAATNATAHASVHFTSRSETATPHWGGPSHTATTPFGWSSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMR1</accession>
    <name>A0A2G8RMR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphodiest-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMR1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMR1"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60286" checksum="FB932C0E752DA4AE" modified="2018-01-31" version="1">MKPEYSEHKLSSDATRQSVDDDEHKALISPEDRRFDDVHYDEEENAELPPPTRSRRCLVFGVLFFSLLLLSIAIPVRRFFSSPSQTTTRPQLKTQGLLSNGTHDFKKTAIIVSIDGLRADYLDRGLTPHLLAISKDGLRAKSMQPVFPTLTFPNHWALMTGLYAESHGIVANNFWDPATRREFHYNRIESTWVSEWWYGEPMWETAEKAGVRTANLMWPGPPKTTSGASPTYFVPWKDHVPLKEKLDQILRWIDMPIETRPQFIMAYEPSLDQAGHLAGPTSKLVNKVLKQVDVFARDLHDEIEARNLTDIVDIVFVSDHGMTDTSHPELIFIDDILGAGYAHIAHEDGWPAMGLRFDTPEHTDTHLAVLRNASRASGGKFDVYTHATMPARWHFTENLRIAPVYVVPRIGYALTDRVENGSGMNKGSHGYDNTYKEMHAMFVAHGPFSAVVKAIEADRIHAAAASSPVRRLASLFGRDLARPNKGWHSTADDAYVMETFENVQVYNLMMKLLGIEEHAALTNGTKGFWDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMT6</accession>
    <name>A0A2G8RMT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMT6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMT6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="309"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1023" mass="113771" checksum="502EBA02665F4A15" modified="2018-01-31" version="1">MLVSHSSAHLRKRPTRPQSEQLVPRRRRADSTNASLAESPREAMPSSPPLPRLPQAQQPGPSTPLPPLPHPKSLGGPGDPLNRSTSGGKRKLFRFRRPATANADSRPAAREPEPQVVNHHKHSALSLSAFVNVNPPFSPVVPPRPPRNPARINLALRPTSSGGLSSKSPRLHVVADEPRQRQKVSGETAADWEFPLPRGSEFPLQRKKSKSRRLDSAQITQDASATSGVQFSTVDRTILQELRQKIRAREEQFVTRSGRKYHAFAPGDVPYPRSYDRQMVDMDVWDDLWQMQLGGSITMHVFEIPPARVLDLGCGTGTWILNAAREWKTSYFVGLDVVPLHPDLLQVGCFDLAARITWVQGNFLESLPFPNEEFDYVRVTRVARGVPEDKWDSLLEEITRVMKPGGAFEMWEEDLHFPGHRGESVHIIDSPDPMHPPTPPHTDSSHSSEQERSPTYNFPSPVFPSPHSLAFSYSLDDVTRVRGNVSQDSKRRLHASPSSPNVAQTPVLMRTVERPPTNPHDHSLLETIHDEMHASRFINLEPVSLIANLLPLHFRGRYPNIQTFNVSTLNGTLPDVRAPPPIVITFPPPPSSVPDQRSDPSPKKLDGTVDSDFDVEGSYHTESPTEIGSLAFPQDSPVLHARDVAGGTPFIALDPARLGGFSPSAIRRATVPSAYGDNATHTRHAPKTSPPPMSSNSPIMMSKLAARTTSSSSSTGNPLPNKTINFDPRSLNLLLMLRVNEVLGCAEPMWDWVVDFQESISQSAKASKGRGRGGGGDGWLGSPTTPEHITLRSPRRRRHPKQDALVNLTRMDFDDLLRRFELDMKARMYLAPAVEDRLGWPSYPATRTEERDTFEAMCTAWAEYEHRQAHAATAAATHSRARGFSTSKRSPSPPPPLPTPRNSNLFEESEATRRRRTGPPARPRTSPATGQKARVDTFPIPSGSNGLLRNKGEPERLLPAEHWHLDHIPTAKHGELDDVYWKLDNVASAQHRELGHVVSTQYWDIDDLHPTQYRELDHVFAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN39</accession>
    <name>A0A2G8RN39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN39"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN39"/>
    <dbReference type="OrthoDB" id="2788250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="617" mass="68043" checksum="3A98832741FBBB82" modified="2018-01-31" version="1">MSLLSLSPELVVHILSYLAYTDLHACRRVNHALDRLIQSSILLQYTMQLQLSGYEDNPSSPMAIVDKLRLLKQQESAWSRLDFQPPKSVRIPFIPSSIYDLTDGILLLGEHVCGLQSGADKIRWARLSALASGDTFVEHWEKIDVGAHIIDVGLAVQEHDLIVVATDRETDDHQTIFELRLIQLSTGISHPLASTPVLTLATIPSPPNQVTGQCSVCIEIIGDLLCFMFHYPSGSTTPPAMFEVYNWKTGQCLQLRGIDCPSYSTFTFLAPDIIALPNCTDNAIELCRIDAEPGTSGQPLELQTSCVLQLPRLGSGHSIAQVTCRSEPKVTNVTRYARAFRSRDPFHLNPENAIVIFNVMTHDAHGFHECLTLIVHTASLLAVLAAKQSPTPVPELPALGKPFVFGLASLPLPLPLGDDPRSVPWNQWGPWCCRWLETSFGASRWITTTCGQRYVTVEEDPIEDDARSSTIVVYDFNPHTVRRLAAAHRKKRRRLRGYWDVTLPEGELAVGSGGGGEVATLARLEGGVLIPFTDPRTRVIGQIQCEPTELMAGYAMEYRIFDEAVRTCLPYAQLSSFETFGYGAVLLDRNMIIGVKLNDSDDIKELVIHAIGAGAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN97</accession>
    <name>A0A2G8RN97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL22987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN97"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013762223" description="Transporter" evidence="2">
        <location>
            <begin position="20"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="10914" checksum="BED11FAF249DC250" modified="2018-01-31" version="1">MIAILITVLIAFLVAQAIAAAALILAKGDEQEAERREEDDAQPDNTLGLFWDGGPMYPYDTLTSLDKDDASFADLQPLPPYIPNYTIPDDDDYPLPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPE6</accession>
    <name>A0A2G8RPE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPE6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="9740" checksum="79366520F0721959" modified="2018-01-31" version="1">MICNGSMLMIDGSFSDSATTDAAGLGSRDGSRLCSAMGASASISSGSACVRSCCASSTAGGVRTPTCEKIAGTPDDGRRSGNSSASAPGPPDSDVEARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPE8</accession>
    <name>A0A2G8RPE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPE8"/>
    <dbReference type="OrthoDB" id="2538135at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="169" mass="18140" checksum="3744312F3006010A" modified="2018-01-31" version="1">MNQDPPYHLFDGLDDSHYPPTTNTLHGGPLYNTVHGYCPAIFPMSAGSLGCPSPQAATNTGPFVVMHIDHYLNLMRRLEVPFEPVDPAIGHASEPATRHGMDEVVSAVRVPSRDVEAPGGGLNSTAGTQVGNHPVRKPHKMRSKVARRAQDASGKTSNANERSIKITGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ15</accession>
    <name>A0A2G8RQ15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ15"/>
    <dbReference type="OrthoDB" id="2985022at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013715120" description="Transporter" evidence="1">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16721" checksum="F9845FD7A398DDA0" modified="2018-01-31" version="1">MQFSRNITHLALLVLALSVIGAATPLSQPSAEGGATVAADEPYFMSHEQMMHWIANTDANLTFIGKSINPLTPRSARDTMVTYCSSRILNVCGGPCTVYNGSAKCLSAPATICLAATKDVAICTATGCTGDCTDYYNCTAKMSDGFCSAPDTQSIFVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ36</accession>
    <name>A0A2G8RQ36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14926</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ36"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ36"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF15">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013963677" description="Beta-lactamase-related domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="4">
        <location>
            <begin position="47"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="591" mass="63269" checksum="70696F0098645091" modified="2018-01-31" version="1">MRAASFLATLLAIFPLSFSSASPHSSPRDNVELASRSASIITPEISALAESLIADYNVPGISVGVVRLNGSSVITEYGAWGNRTEDGDLADSQMITGLGSCSKAFLTSAIGILIDDFANGRNVTALPHGLDTLSWDTKVQALFPGDSVWKLEDNWATEKTNIADMLSMATGVTSNQFVYTRNDTPVSLAQRFRYIKPGFELREQWDYTNIFYFFATQIVTQYSGKTFQEFVKERIFNPLNMTSTTYSTQEANSTGHLSQSWAFVGRRIPIIIDDPVTSNLVAGAGGTLSNAVDMSKWAATVLNGGVDPVMNKTIIPQSAFAETTTARMIQAGNVTAEDETVSIIGYGLGWQRNSFLGHDVITHDGGIPGFVASLFVLPDDNLAVFALLNTDAPFQEVIPKAIISSVLGLNATTTSTPSTGAGSRRSLSARDTSTSGNCTQSSTALEKFAGDYTSPAYGNLTFCAPTSTNGSASAYCNSTLADFASIGPLDSNTLYASTNRIATHVSMQRTCAGSDDGAFIVTFQSIYANGYGRNTTAFSEAFSSELPPTHVECIMEGSNVTGCGWLDIEVSPIKSTGTPEERAQIWWTKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQA5</accession>
    <name>A0A2G8RQA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13435</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQA5"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL23686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="436" mass="47145" checksum="961DCBA36E57290D" modified="2018-01-31" version="1">MPPVPCNAPAPNVPYFVPRQVPPSGTAIQPQHDGNDIPTLFQPITIRGVTFQNRLWLAPLCQYSSENGLISPWHFAHLGGILTRGPGLSIVEATGVLPEGRISPECAGIWNDEQAAAWTKIVEFAHSQGQKIGIQLEHAGRKASTLAPFVHSGALADIHQGGWPDDVVGPSPIPYSSNFAVPKELNKAGIKRIVAGFIAAARRAVKAGFDVIEIHGAHGFLISSFLSPTSNKRTDDYGGSFENRIRLAVEVVDGIRGVIPPTMPLFFRVSATEWLEESLPDEPSWRLEDTAKLADVLSEHGVDLIDISSSGNNAAQKIKSGPAYQVPFSEAVKRDVGHKILVSAVGNITDGKMAQGILDKDLRRPETLTQDVKEGSGSTQDVAIMGQSDIIFVGRLFQKNPGLVWQFADDLGVDLRHSSQIEWPFRGRGGFTASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQC8</accession>
    <name>A0A2G8RQC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQC8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQC8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013923528" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="28"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="57478" checksum="054D025830862505" modified="2018-01-31" version="1">MFASSFLSLVAVYVVATLAAPTPSAASPTVQLDNATFVGTSDGTADSFLGIKFADAPRFNLPVPVGPYTGMQTVDAFGPACPQQGSNAVTTLADQLAGNPVASKLQARADVPPSEDCLNLNVYVPAGTNSTARLPVAVWIFGGGFETGSADTVDGGVIVKRSVELGEPVVYVGMNYRVSAFGFIAGQEVKAAGVGNIGLEDQRVALQWIQNWGESAGAISVALQMLTNGGDAGGLFHGAFMQSGAPIPVGDISRGQAEYDQLVQDTSCGNATDTLQCLRALPYDTLKLAVDQSPGIISEQSLRLAWLPRVDGRFLTDTPQNLVLQGSIAPIPHVSGNVNDEGTVFSLVNSMTVLDDTAFRAYMLSNYIDGATESDVGDLFDTDYPDDPTQGSPFGTGTNFSILPQYKRLAAIQGDLVFQAPRRFFVEHTYNRQPTWSFLSKRKPQSTFLAFIGAFHASDVAYNVFAPGDMTDYLVHFVNHGDPNGAGDGLIDWPQYDNNTRQQMTFVDDDDAPLVITNDTYRVDGFNKLTELSLQFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQY5</accession>
    <name>A0A2G8RQY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQY5"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013782267" description="Phytocyanin domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="3">
        <location>
            <begin position="242"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="481" mass="49025" checksum="B6BB6814C7AD54C1" modified="2018-01-31" version="1">MRFSALLSTALLVGFVTAAPTKDSSNSSPSYDSSNYSSSSSYDSSNNNYGSNSNNYGSSSSSSSSAYDSKSTDKSSKSSSSSSSGYDSSNNNNYGSSSSSSAYDSKSTDNSNSKDNSKSTMMSDSSSSMKDSSKTTSSEMMDSTSTSMYYQSTYSTSSAMATSTMSYGSGSTNWGNSGYNDCVQQCIASYGAPPATWTPSSTQSSSSDGSYSGSTGTGATHTVIVAPTQGVLRFVPFAVNASVGDTVMFVWNAKNHTVTKSSALEICNKTSDAPFASGEHDAPFTFTQVVNDTNPTFFYCGTPGHCQKGMFGIINPPSAYMTSTSIAQTMGSAVSNSSDMAAMMAYTNSLTSGNDKAANWGQNIDLATLPDWSHSLVMENVMYTRSFLGANPETLKDDGSIDLSGDAPKMIPTDMAPVNAAVDNAASSSAPAASSAPASASSSAAASPTGAAAGKSNGAASTAASSALLSVAAIAAAVLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRG4</accession>
    <name>A0A2G8RRG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSI_13852</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRG4"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PIL24100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="241" mass="25990" checksum="0CD6E49FCD62510A" modified="2018-01-31" version="1">MNKRKGSSNGHQNGGQESLAPPALHQYQDTEGHFSLVRNFRLADLVTIANGICGSFSVFMSAKYLVTNDEDYLWSALAFPLAGLLFDFFDGKVARWRNESSMIGQELDSLADLISFGVAPALLAFVVGFRTYLDTVVLTGFICCGLARLARFNATVALVPKDAKGKAAYFEGLPIPSSLALVGLLSYWTKQGWIAGKQGLPLGTITLWGPPGGDGELHVFSIVFGLWAAAMVSKTLRVPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRK2</accession>
    <name>A0A2G8RRK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_13891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRK2"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08662">
        <property type="entry name" value="M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1380.10">
        <property type="entry name" value="Neutral endopeptidase , domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000718">
        <property type="entry name" value="Peptidase_M13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018497">
        <property type="entry name" value="Peptidase_M13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042089">
        <property type="entry name" value="Peptidase_M13_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008753">
        <property type="entry name" value="Peptidase_M13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733:SF167">
        <property type="entry name" value="FI17812P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11733">
        <property type="entry name" value="ZINC METALLOPROTEASE FAMILY M13 NEPRILYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01431">
        <property type="entry name" value="Peptidase_M13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05649">
        <property type="entry name" value="Peptidase_M13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00786">
        <property type="entry name" value="NEPRILYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51885">
        <property type="entry name" value="NEPRILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 N-terminal" evidence="11">
        <location>
            <begin position="154"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M13 C-terminal" evidence="10">
        <location>
            <begin position="669"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL24139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="878" mass="98197" checksum="3E6BF7E62E95A519" modified="2018-01-31" version="1">MSPNAQPLLSPSLETAPLLQNVSHPDGVPADQDEEPSFIDRLAAIVQEPLSPLTKVLLIATLIFLLLSSVFIGLFAGAQHKLNHGERNGGATVTVTATVTTTSQATTTAASTTTVSYPVPPEPTSPPEEPVCLSASCISLASSVLSALDESEDPCENFYDYANGGWLKSNPIPSDKGKFGHFEEIALQNKRLLQQILSEDSSSHFSETSSLMASSPYDEQLLQKLRGLYQSCLDEDYLNEIGETPLKELTQKIREVFRGKTTVVDILKSKSEQERDRLTAVVAYLHSRGIGALFSYTTDGDVGNDPNLMTLWISQPDLGLPSKEYYEEESIVDLYQKTLKRLLITLDNEEDTILEEQDMDEAPSKLVVHEERLKVWPPWPWPPWGDDDDGDSPENRTERAQRLAKEIVKFEKRIANASLDLDILYQDPIATYNPVPFKNVSASLPEFDFSTYFSTFAPRNFPNAIILTSTTYLSDLSRILNDTNKDVLEAYFVTRAGLAYSSYLGLETEAWQAVRSLEEVLNGIKKGAVGDRAEYCVGRVESALGFALGRYFVRETFGGDSRRVATKVITDIIGAFKKSLKKLEWMDKKSATAAAGKADALRVKVGYPLSPNTEDPRSLANWYYRVTIKNDTFFENMLSAEIADQIRTWFRIGKQRDPQSWEMYASTVNAYFNPPANEIVFPAGILRPPFFRGDWPGYMNYGSFGQVAAHELTHAFDSAGRLYNQNGKLEEWWTNSTSNGFNVRQKCIVDQYSNYTVDDGKGGKIHVNGNLTSGENIGDSGLIQAFRAWKAQYNDKTEFLLPGLNYTREQLFFISFARSWAQNIKPQAAVARVRTDPHSPNRYRVHGTVSNIPEFAAAFNCSRHAKLNPPQEKRCIFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSD7</accession>
    <name>A0A2G8RSD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSD7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="13730" checksum="F83D01D0F482E65E" modified="2018-01-31" version="1">MLRIPSPAHIHINLHTAFRMYVRHWLGCPLCTCPPRLTSGPSSIIAFAFVFRFSLFHRAFCFPAARSIAFHIHTRSLVTPAFGSRPRGLSHLCPVQFALYNRSRLHHDPLVASGRKPRLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTI2</accession>
    <name>A0A2G8RTI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_12695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTI2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTI2"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="122"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="234"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="507"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="809" mass="89214" checksum="2C4EC278524D3E4A" modified="2018-01-31" version="1">MAEPGNGDTATAILKPKKSPNRLVVDEATSDDNSVATLNPATMEALQLFRGDTIIVRGKRRHDTVLICLSSDTVEEGKIQMNKVARNNLRVKLGDVVNVHACLDIKYGQRVHILPFDDSIEGLSGNIFEVYLKPYFLEAYRPVRKGDTFLVRGGMRTVEFKVMDTDPAEYCIVAQDTVIHTEGDAVKREDEEANLNEVGYDDIGGCRKQMAQIRELVELPLRHPQLFKSIGIKPPRGILMYGPPGTGKTLMARAVANETGAFFFLINGPEIMSKMAGESESNLRKAFEEAEKNSPAIIFIDEIDSIAPKREKTNGEVERRVVSQLLTLMDGLKARSNVVVMAATNRPNSIDPALRRFGRFDREVDIGIPDPTGRLEILRIHTKNMKLADDVDLEQIAADTHGYVGSDLAALCSEAAMQQIREKMDLIDLDEDTIDAEVLDSLGVTMENFRFALGTSNPSALRETVVEVPTVKWEDIGGLEKVKQELQETVQYPVEHPDKFIKYGMSPSKGVLFYGPPGTGKTLLAKAIANETQANFISIKGPELLTMWFGESEANVRDVFDKARAAAPCVMFFDELDSIAKARGGSSGDAGGAGDRVLNQILTEMDGMNVKKNVFIIGATNRPDQIDPALLRPGRLDQLIYIPLPDEPSRLSILKAALRKSPVAPDVDLNFLSKHTHGFSGADLTEICQRAAKLAIRESIEADIRRAREKREKEEAGDVEMEEDENEEDPVPVITRDHFEEAMRFARRSVSDADIRRYEMFAQNLQQSRSFGSSFKFPEGAPAAPGAEPVAAAANAGFGADTQDDDLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTM5</accession>
    <name>A0A2G8RTM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTM5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="261" mass="26943" checksum="C4CF91040D650244" modified="2018-01-31" version="1">MPRMGCPALDAVLVGRELGGVQNEPSRDAGADMGADEGISKGTGSSNSSSKKSTLRSPDGLHNLPLFTDRSASPGAIWISPSGAWMMTVLRRDCLTEGELCTDVCWTSALGLLSSVRDPADVGREATSLDTSVTGSIVVYASTWGCEAMAGQASAERPLVSCHSTTRSRINRHSSSSASGSCAVVSIAHLVSGSRLGGGCEGGWCSTSVGVKGGGGTRALRLLHMVDSPMSNLEDWPARMLTRLNDGLVGEDPRNADGMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTU8</accession>
    <name>A0A2G8RTU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTU8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTU8"/>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="264"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="621"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="824"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="940" mass="104673" checksum="AADD981F947B155C" modified="2018-01-31" version="1">MSTISTHLRNFKEPTKDQLTELYFALPQSVNGGVNATGGPSGAAGNANGEKEKGAEAELEKMEINAVLSLGVQGEEDSYAGKLYLLPPYLTFASHDRKSSRFTIPLCTIRRVERLNARAGVYALSLALWHGMKIVVQLTSLRPTADLFCSLLRDALKVELQKGHMKLVKGFVKTCYSELLVSNATAPDGVDEKAEAKVAESTQEGSASDSMYLGGLGLKFKFPGDPKKLREASKTKLWTNYLRTHGRNLTLLRYPQCTRLIQVGLPNRLRGEMWETLSGSLYLRFENPGYYNQIIAENQGRTNTSTEEIEKDLHRSLPEYSAYQSEEGISALRRVLQAYSFKNPETGYCQAMNILAAAILIYMSEEQGFWLLEVICDRLLPGYYSPSMHGTLLDQRVFESLVHRCLPVIHDHFAEVDVQLSVASLPWFLSLFINTILKINGEKLLKIQDDGQFIHLMREYFASLGDSAHPHSSDPRARAITRFQELLLVSFREFAVITDDTIHSERRKYRSEIVHSIESFSKRSAIRNLRTLERFSKEQAGLIYDALFKAICIEPPPAVSLPPPSLLTTKDQPEERPETRIGLKTFKIFLSEICTWARTEKIVSNGFKDLVSGLNGVMFNDLMENIEWFFNLHDKNKDGYLTKDEVLTLSESLLFIFRHEIGDAYLGAVSRFMSNAFEYGDALLPRPDGADPDVEAPPIESNQPYINLATFRMVVLADEILESFFETDFPATFRLEPVPIMDIPNSNSGLLGGIWQNIATDDNRKIFNKFTDEIGRTIGKHQVFTRPAIGKYTTLEEPKARESLLTPTMRRSASKASLVSPTDSGPEPSVSSGSLSRPSGEALSPGSGKEGASVPSSASSEFAPVPSMLQAAANAAALMERTPFAIDDAKDEEDETDDETDVEDDGVMDEVDAFLEAHDSGLTEAERELAQDLINAEPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU22</accession>
    <name>A0A2G8RU22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU22"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU22"/>
    <dbReference type="OrthoDB" id="7482721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08290">
        <property type="entry name" value="ETR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051034">
        <property type="entry name" value="Mito_Enoyl-ACP_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43981:SF2">
        <property type="entry name" value="ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="180" mass="20309" checksum="3FC3CF6EBB2F4A49" modified="2018-01-31" version="1">MLRDFVDLKEDDWVLQNGANSAVGQAVIQIAARKGIKTINFVRNRPDLDNLIASLTQLGATHVFSYDALVDKALVKQVRQWTSKAPIRLMLNCVGGPDTTAMTRFLGENAHLVSYGAMSKKPLSLPTSLFIFKNLATHGYWQHRWYQDHSRQERENLMRTLTGLKVSDFMRITAACTDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUS0</accession>
    <name>A0A2G8RUS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUS0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="357" mass="38203" checksum="3EFD36FF9FBBC8C4" modified="2018-01-31" version="1">MSSQSLPGGTQPTIVRSPTILPYAQYCHSWSIYDSAATPVPVDQQSATTASARVVPRQASHPPLVSTIAHEQCVALAHDPVHSQPPMGQRAATASPRPRPELTYIAGEASTAQLTSSATSPQSTWSENPHVSAVTPSTHVAPEHKPAHPAAQGSIWSEDDFIEVYQAFFLPRRIDNPDSKASASGPKPTPRDSPNVTMRQANGGLEPKGYATTPTLTDSVIPTTGSGTDEQRPHDVSSTQFGGSEYLDWSIPCMVIEPIDPQRLTELEAAVIAGYADTLYLQAILPSTLPEAIYVNMHSSPLVWQTSHSKLAETPQCPRLALTADSVPSTPATARCRSPTSAQTSRRDKYTANARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV32</accession>
    <name>A0A2G8RV32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV32"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV32"/>
    <dbReference type="OrthoDB" id="3270311at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="635" mass="67367" checksum="B0D225751CC54D2B" modified="2018-01-31" version="1">MTPSIAPLDKAGASTRILLHDTQAHLERFGERVVQLTTGVADAKRELVAVQKLYQEDHEQLVERMIGLANRCQTELQKTIGTPAQSSELRDVLKAVEGLGKRMEALDKKVDVLSMVGQTQSQALQNLQDQQGQALAALLPLLPLLQAVPLHIENARNHVKDVVTDSKSDVQRWIMGVEDRVQQSSDALHNQLQVFLPQDPAKKGLPELPPHDQDHVSDLQRHISTPVAPGSPGICLTRGTPRFRSASQKRPRSGSPSDTSSSDPAASPSGSKRQRLGNPSGRAASTARPARPSSVTGPRRIHTPTVPTTGPPSLSHASPDLSLLPATVRSSDRLIRTPLADLDPRTPNVTGTPASIMPSVPKHQQLRGSRSTLLTRPSPSPAGAPSRTPSPQSNIHTAQARARTQARAQVLPAPAGSTMTHTHTRTPPPIIRATAPITPGAFKLPLPSLGLSRTATATPTPQLRTTTLSQAHSTSSSSSLRHPPGQRQRSARTPGEAQASRTRSNANTLRLSASRGVAVHDSSSNGDGAARVSRASERVTVTVPLPLPIGVGAGGGAAPRTPHLPADARSVAPLLPPPPPSQAAGAGNLKGKPMSLRDRRAMAMLAEDRLRDEGKRFIPLDDEEDEEDADANVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV43</accession>
    <name>A0A2G8RV43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV43"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV43"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03053">
        <property type="entry name" value="GST_N_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="90"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="207" mass="23600" checksum="48FEB4CCC0F04618" modified="2018-01-31" version="1">MVLKIYGHLVAPCTQRVLAVAEELGVPYELVVVDYTKNEHKTLEYLAHQPFGQVPYIEDDGVEVFESRAICRFLALKYGGVGTLLPAQSDLEGTARFEQAASVELNDFEAPMGLLAWELRYKEYYGLKADLEVAKEHRTKAESRLDGYEAMLSKTRFLAGDELTLADLFHLPYESLVTEQEFDFVKPESSRWPNVARYKLPIYARLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVB4</accession>
    <name>A0A2G8RVB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RVB4"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1056"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1335"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1434"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1487" mass="167274" checksum="20814F47933F0350" modified="2018-01-31" version="1">MPPLVDSDSDTDSDVDPQEFDDDELQENEDDLLPEFQEPDPHSSEEHELGGVSRYIHDLESFDPRSRLLSDGDSGDDDETLPNLNPSDVEEEYDIEDEDEYVEDAPSSESDSEYLVMNVELGVTLHELLDNLLEGDYSEEGSSPPSPVPNQMTPEHQETDGGAASSSTSQPATTQREYHRRITGLPCDANGKILAAGAAPTTSAPASDDWAPYKDRLQFEVADLLYVEEQMSGGNIDKLLELWAASLLPGDPPFRNHSDMYQTIDSTPLGEVRWMRFEITHDAADSCPPDAPTWMTQSYEVWYRDVREVAMNIIGNPDFKDQIDYAPFRESDINGVRQLRDFMGGDWVWRQADEIAKDPNTHGAAFVPIILGSDKTTVSVATGQNEYYPLYASIGNIHNSARRAHRNGMVLVGFLAIPKTSRTYADDVHFRKFRRQLFHSSLSRILSSLKPGMTTPEVVRCGDKHFRKIIYGLGPYIADYPEQALLACIVQGWCPVCFADKTDLEDPEAKLRSRECTEDLVREHELGVLWDDYGVVGDVIPFTNDFPRADIHELLSPDILHQLIKGTFKDHLVAWVESYLIKKKGKKPALKILSDVDRRIAVVPAFSGLRRFPQGRGFKQWTGDDSKALMKVYLPAIVGYLPPNVVSAVRSFIEFCYLVRREVHTTHSISMLREALDEFHKKREAFRIAGVREEGFSLPRQHSCVHYEDKIQDFGAPNGLCSSITESMHIRAVKEPWRRSNRFEALGQMLISNQRLDKLAASRVQFKDRGMLEGSLLQSAQQKLLGPNAEPPTPARPSATVRRQNVPNDGYVGSEENNEDTIVDGPRVLSSVALSLTFQRNYPRVANDLGKAIGLSTLDQLIRLFLYHQLHPDSSETAIDDCPSLEFESIYVHHSAEVVFYAPSDPSGVGGMRREFIRAAPDWRKSGPRYDCVFLNRDSAQKGLLGLDVAQVKLLFTLCVGGRRYQCALVHWYQRDGDTPDKQTGMWIVKPSFSQISEPSEFGKELEGMQKQFEANSHIEVLTERHRMVQDQIVIQKRENADLLTRNQKLFDHSSNRSAMNVPSSGLRRRSGRAFKPGSSRKAVERSHPSDLMANVQKMHNDLERSGSTFDSLGGKEMKGAGVTNLGLHDEMQGDILFIAPRRLSTRTWAQAGSQDMRPQLSQERESVRPVTLQKDLEIRDQQGEIEKAGNEKKLSVYKRRASGVNGITSRANEDLSHEQQLEAEVAIGRYNRHEFGHSGKCAFDVDSAREMLIALAVRTASGVEILRQAVESGRFTAGGGHQHAEVVTDLLERRSHFSCKSRRSALKVAKADLATARSHVQEFQDIGQANDAALANLNATHDEYKAETEAETEAELEKLRLAEERSNEVTQQNGELQRSFDSERAVWVKDKELQGTILGQQRGAFDKEMADLKTRCKDLGEKINQLEPTKEQVRIAQADVEAENEQIKMLENESRRWQERNAQLLSKYDRIDPAGVQSLKNEIAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVI5</accession>
    <name>A0A2G8RVI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVI5"/>
    <dbReference type="OrthoDB" id="10514547at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="21058" checksum="55F138E68295205B" modified="2018-01-31" version="1">MEPQPYETPLVELALVSSWLAFQWEHGMSDGLADLLAVFSASPLTHLEVVGLCAPVSAETWATVFRMFPSLVSLDAGAEAEGALFAGLREAESESACMESVAWGDCTEAGSRIPACRGLERISVTPYSGLSQTPEQILEPLIHCLRYRAERGIRVKQLYLDLNMRIDGVKRYLPQLEDLVSNVKVKCRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVR3</accession>
    <name>A0A2G8RVR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVR3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="65" mass="6954" checksum="A27D4C599D328817" modified="2018-01-31" version="1">MADHSSFPFPRAWDPTAARKSAAPRRTHPGAGPESESAATERLEVRRGAGRDGSNDALVRSARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVW3</accession>
    <name>A0A2G8RVW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVW3"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="554"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="681" mass="73532" checksum="4BA0908C5D0E607A" modified="2018-01-31" version="1">MHWDRLIGVIPAPVTSLWLGPVHGQVYYPYLPCASNLRNLTSLDTCMIDTEISHLVLSPSIRTLRRVYSSADRVMLAFDQLECVERATVLERLDIVCFGETEKEAKSMLEETASRRSNPSLLLLSLLAFTHVSIFTRASPPIHWGPCNSSSITNPAILCSFFEIPLDYYDPEAGTGRLALAKLNATQERRGSVFFNPGGPGGSGLEALDSNGETLLEVTGGFYDIVSWDPRGVGSLTIPGEIFCFNSTEEHDAFFNGTIELAGIEYTGNFTDATDIEILYSQASIMQQKYKKLGEKCLSGPSGKYLRYVGAAATVRDLVALADALDGPNQSVNYIGTSYGTLLGSWFVNMFPERVGKVILDGVVDPITFATKQISLSGGNIITDADKVYEGFVTGCALSGSQGCPIASNASSVEEVDKNIQSLLQAAHDAARKDPSVAVSSSDIRSLFLSQMYSPGGWSTFANSTYPQLVQAVGQETHKNSSLVPREPSPISMKRPSALGRRDTSFVRRANQSAGVSYTSSAIWCGDSIDQPTTAMLDVFNGIIARSRNVSRMYGGLWPAAIYKCPFWPVRSVERYRGPFNKTLANKIIVASNLFDPATPFANAQKLVDLLGQSAILVTQNGFGHTTFAAPSTCANAIAYAYMVTGKLPDGPTVCDVDAGFELFQGVNTSAILANMHVSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW23</accession>
    <name>A0A2G8RW23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW23"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="117" mass="13050" checksum="244D32539151130E" modified="2018-01-31" version="1">MYPLLPRGWCSVMGGWNSAMGSLAAVDQSLDPAGAGRRFPRLRRIELHAHFWSSQEFSSSYDAAEKRETQDIERVADPLPRLKAAGLLQEFRVDNVVCGPGASDFMDDVYWPSDSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW87</accession>
    <name>A0A2G8RW87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW87"/>
    <dbReference type="OrthoDB" id="2760482at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="83" mass="9103" checksum="0A1305ABB6E59E1E" modified="2018-01-31" version="1">MSFKTNAALPNLAADAAAMAQHEANVAAITQREAKDTMTSARLECLLVIWRVREALQAMPRPADNMTIRRWNHGIAQELVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWV5</accession>
    <name>A0A2G8RWV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11718</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RWV5"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="544"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1305"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="193"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="695"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="885"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1259"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1474"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="887"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1179"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1489"/>
            <end position="1499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL25964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1633" mass="177997" checksum="0BE2C969D6E76175" modified="2018-01-31" version="1">MSSTTSNEPHDSPSRNLDLPPPATPASPPAPLPRPAVSPSNSQLKFVSPDAGEGPVFEPLPPEIANADISIAPDGSFVETSSGAAARELKRRYDQYWGVGKDVRSPYAITAFVNQHGKQMYRLGHRELSAPAAATQDAADRQSTGPPTTSLLPSNITSPNSGAAHGKRRSRMSVHSFLPVFKTGVTPVAALNPVVDPVRSPPPRRLRKTRSIPDGLSSNGPSNESVSPQLITQTIGRPHAHSVSSVDAFAPPVPQHAPLANQTAPRAPSGPGGDFFAEAMAWTNIPTSPLASSSSSLPSRTHPPSSSPPSTLGRGEISHPFGAGVAFESPSWRSPSHLSSPPVLREMQSFESGLTARADYLPKVARISRLSLTSSLSDEDPQNLTPPSNSATPPTSSSASSSASSVLPAPETPSVAPINLAATTLHSRYTTALFDVLQTYRGLPTLDKIVSTPHEPTIRLSLRAEDSVAPRDDPRFVIWGDVDTERDAHEDISTSSGTDLSSGHSNTANSRRSRMGGKEKPHIYATQHTNEFGASSSTGRTKETKKMLVAATIERWIAQLTSELDYDELLIFFLTYRTYVSAVDLGHLLICRFHWALGETSNSRDEMVRKIVRVRTFTAIRYWLLTFFDVDFVPNRELRLLFAEWLNSLRRDPILQKHRDALKIVYQLRKVIVDCKDSHMRKLYRAARKSVDRLKSSDANSHLHSAPGAPRLSLDPNNVPRPSVDSQARSFIDPEDYDIDFDFDERGQDFGPFGGTSSNGTSANSLDLVMMRQPLHMAVLQYGKQNPSPVGPTGPHPNTPVSPFPHNTISRVFVNTIGRLGRWKRVLNSRATVHVQPSMTAGVDVSAFDVEANETGDLLLVKGGVEQYLRMVESQMNVSMIERPSTAAASMSSPRMNVGSLPQSPKSPSSMIRVLPPENVTPPPASIPEEEPESKVPPTDPPSYDEAAPFHVRDSIMTYDSEIHSVYGDQSDYQGPVTPADFSASPKLRHGLDVVSIDDLDLSDLSSDEHMELSPPPGLGLKKATRKLPTRRDFEFVRQSMSSVSSMGIRTRESMLSQGGSSVVSSSSEVDPDAADSAAMQGGPLQAWQINAILDSLSDEEESGDVETALRRLEGQINQDKVKEKQTKVDQWIQSMHQRQADGRFGRESEGSGSDEDYGEVERRRFSGDSVQEIKVGMSATSPQAGSRRSSFTSVSQVPSASQSTTVLPSTNATSPEHLSIDTLQTPSDQGDEADALTPLTEARPFVEDAVPIEILQSRVESRPSTSHGSPSKDSRVAQQLGNIPPPPSIPSSLRRHHSFVLNYRAETLMQHLSMIDRELFISISFEELITWHSIGEAEDANVLDWSHFLRERARLKAEGRSGSKTSALMVVRGRFNLLANFVLSEIVLTHPSERAAVINKFIRLAWKAYLLKNFNALVAIITGLKSDWVAKAKQQAFAKIGAWEARMLRDLTAWTSSVGDFKHIRQTVDSLVEAKSSTQEGPVKSADGQAQTTRSRAASDSKPPQDPACIPFFGVYLAQVQRYCSLPDLIDPTSPHEPVGIDSVTNTFEAPAHPDVFSTLAPLPASIQLEPLINVHKQRLISGVVKSLVAGQHLASKVQFPLDKKIFQKCLKLRGLDGDTLERALALYGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX38</accession>
    <name>A0A2G8RX38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX38"/>
    <dbReference type="OrthoDB" id="3214103at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="300" mass="32619" checksum="BE385B2EE53BA2AC" modified="2018-01-31" version="1">MATLDIRAVEINPIAMNITNFFAAQEPVFALQFSLSALLFDVGPGAPCGYWSIRIPLTGTILLYLSTSVYMAAFAWNRESAVRLVSEATDGLFSSTYDGKGSATYSEAVLKQSWMATVALGANIVLGDAIVWWRACLIWRHKAVYWTGPILVALTLASAPRRRLRRYLGADTAQTRVLKVLALLVESGTVYSTILVLVLVLQPQGHATASDPGIYFLYGCLVPIVAIYPTIIIVLTAANSSPLERGLSQVGADSDGPGSYNWRQRVPSTAVRLRRSVICSYEEEQDRKGSIGPNSILDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXN5</accession>
    <name>A0A2G8RXN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bola-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXN5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXN5"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9960" checksum="EA244C7986980D89" modified="2018-01-31" version="1">MPISAADLETAIRRAMPVHHLEIEDTSNGCGENYEVFVVSSAFEGKNTLARHRFINEVLKDQITQMHAFSQRTLTPAQYEAQLAQRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXS5</accession>
    <name>A0A2G8RXS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_12050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXS5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXS5"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL26294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="569" mass="59789" checksum="82F1ED7BB80292BC" modified="2018-01-31" version="1">MSLKTSSTAAAEPVTASQTDVTAPSPSSGFRKGSAFWLTFIAVLVCTFVSALDLTAVSVALPTITESLHGGGKFVWIGSAYGLSSAAILPLSGRLADAFGRRPVMLASVSLFLLGSALSGASQNMNMLIAARTVQGIGSGGILNLSEIIVSDLVPLSERGMFMGIISSVWAIASGVGPPIGGVLAQANAWRWIFYLNLPLTGIAFVLVLAFLRVRTPPGSLRDKLSRLDILGNVIIIAGTTLALIGLTWGGVAYAWTSAHTLATLIIGFVLMGGFFVYEWLVPEDPSIPWEVVGNRTTVSAYIGTFFHGIVSTAVFYYLPVYFQACMGSSPLRSSVQTLPLALIISPFAFAAGTLVQVVQKYRWANLLGWALAVVGFGLFSTFDADSSTGKWVGLQIIVAAALGLLYTATIFPTLAPLPVARTASALAFFSFARTFAQTWGVTVGSTVLQNRLASTLPAAFTSQFPSGAQIAYAAIPVINSLSDPLKTEVRNAFADSLKTVWFVMVGMSGAGLLSVALMQELPMQQETDKTFGLDDGSQTTVLDSEKATAVVASESATRQGTPDATTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXW2</accession>
    <name>A0A2G8RXW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXW2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXW2"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TEA" evidence="4">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="2">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL26356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="48873" checksum="880D9C6C756FD475" modified="2018-01-31" version="1">MSHTSLPVPSSSKSKSNFESILAGRKCYRMSKEKNEVVWPPHLEQALMEGLEKYTPAESKSPRGLTRFPNRNKFIAEYILKKTGEIRTAKQVGSRIQQLRDTSAGKTIMKAISDRHYEMMHPTRPNEPAQDMAMSDVYFNGTMVPPMNQVIHVYISVSSAAWTDAYPQPTRPTEVNVLSSSAYSWGEARPLRTIDPTVTFTSPALLTLYSSFTVYYGSTVMHIDQPTPMRSRSSEEYGSGPYLHYTSLAPGYWENLCLCTDLSQYVIVQEITKQPAAPTEKPIPVMRIHYHFNTAPSVPPLSPFALHDDDLEVDYETDELLASHTHTHAAHAALSTSSASPYPSDRSSSPSYSVPGFCSQPLSPVDWTGSSSSSSGASAAWGFPASSVSVSVSPEGPCQVQLPLPVQTAAYGHHHQTQVQAQGGAYGHGHGMQPRGSWTVGGHSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1D8</accession>
    <name>A0A2G8S1D8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1D8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1D8"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="262" mass="28127" checksum="0812F5389D24273B" modified="2018-01-31" version="1">MALASTKRVAIITGAAQGIGRSIALRLARDGLDLGLFDLPECKDLLEELAAGIRAEHGTRIVTVYGDVSVDDDVKRLVDTTTQELGDLYAMIANAGTANVASLHETTTEMYDKLMNVNVRGVFHSYKYAAIRLIEQGKGGRMIGAASTAGKRGVPDQPVYSATKFAIRGLTQAAARDYGKYGITVNAYAPGAVMTPLMTMVDEMHSARTGQPKGSWSGSRSTNALEKYGQPEDIAKLVSFLVSDDAGFITGARQSYYYLGHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1P1</accession>
    <name>A0A2G8S1P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_10835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1P1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1P1"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL27682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="310" mass="34693" checksum="6248FD1C26F263CC" modified="2018-01-31" version="1">MSARINIARPASGGYSPDPHGFANSRPSAGYRAANPDDPIEKLRAFARQVEDYSDIYSQPLKPHLPAIGRFLIVGTFLEDSWRITTQWGDQLWYLQRHRHFPWGLSHLFLIINVLTMLVGSGAVITKRHTEYAVGGLLGVVVIQAFGYGLIFDLNFFLRNLSVIGGLLMVFSDSMLTRKKLFAGLPSLSENDRKKYFLLAGRVLLIFLFIGFILRGEWSIARLFVSIIGLAACVMVAVGFKAKWSAAFLVVTLSAFNVFINNWWSVHSAHPQRDFLKYDFFQTLSIVGGLILLVNMGPGGLSVDEKKKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1R0</accession>
    <name>A0A2G8S1R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1R0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1R0"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="839" mass="91520" checksum="8665C03E5A020043" modified="2018-01-31" version="1">MPFLNPFSADVVPRYALVPAFRQPGRGILIAPARTLERSEGGVDLPALLKEPRVRILSTSRDSLSQANMSVLGFSLLPYALIEEPELQFAAAHFVVSDGRGEVLSHVQPGHVSPAATSHSHPTHPAERVWNSAVAGMLRAHHDRRLTGLRCRCCLSYGLNMHESLSVALATIATLVGVRQSFDRDDVRKLHVDKSAVPPYTPAMTSLDLDTPAHNASRLQSAITRVTLEGASRPELEGLLQDCHDWLDGQPQDQFKDLRAARHLLYHNSRYQAKIQKRDARIADVEHDCSVLKLELEKEREEFAKLEKELAEEQEIATKLEEELHLATTKCGDLEKILDEERTISSAKYTDLECTAFEERDRFALLEKELEEDKARLKAECDEWRTVALALILITSSCSKLDGISTECRRLTDELEKAKRTPPTSRASEPRYYYLHDQKGSKVEPVAILKDDGRDHGNAVKVQVVGTDNMFTLSPIPACKPIPELPSNMMAFLPLSDDAEDASDDDRVRPGPPISSASRSIPIKSRSDSHRPRSNSSLLSRPDSDAMSISAPRSTLDVHMASVSASPSGSSMNSGLRPAPEYSPGSFGGGVGENMLGLRADPSRVSPSSIDSDLKERQERKQRLAALDRILDRGTPQTPHSVMSPRKNSVSDGADRPPPANPRAGSATRTPSPVSSASQSYSSSTMEKEVTAAPPYRPQLLGPVSSASSAAAERERARASSVSQNPPPVIPPPPSSLSSQHPPSTTHISHLTATRDRDAGTPVYPTYGPQPQPQPTPSPLQSRPPHSRRQSNDVHPSMSGNLGSLSRGRSINLGIVQPASYASGLTRSIRAMQEPPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S218</accession>
    <name>A0A2G8S218_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S218"/>
    <dbReference type="STRING" id="1077348.A0A2G8S218"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="181"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="644" mass="71176" checksum="D9D9526A4DF76B69" modified="2018-01-31" version="1">MDLFRETVAGQLIYYGSRKKVLSYPEEHPNWIVPARYTGAIVGDTSRRPSPQPSPVQPGPLASRVSTQPSHRETFYTSREEVDRPLQEGATRLPAIQTGRRGSHSSTETAVVSQKKRGKKTLQGGELRDREATDASRVWEGEVRTVDNITSLPKDPNCVDWYGPDDPDNPRNWSLFKKCFVTFDVCFLTFSIYMGSSIVAPSIEALAAYFGVSTVVSTLTLTLFVVGYGVGPMFLAPLSEIPAIGRNAPYILTLAIFVGLQPAVATAKAPATYFILRFLSGFFGSPALATGGASIADMFEPKKRAYGIGVWGMSAVCGPTLGPLIGGFAFDALGWRWTIWPLFFLSSASLVWLTFLMPETSSANILYRRAKRLRRRTGNANLYSMGEVVQRSMTGREIAMMTLVRPFILNTEPIVGLLNLYIGFVYSLLYTFLATFPLVFQNIHGFNSGEEGLAFMGLFVGALVSYAGFCAYAYYSLEPLFDRKGGTIDPEDRLIPAMFGCWWIPVCLFGFGWTSVGSIHWIVPIIFSSFFSVGTFLLFQAILNYESDAYPDYAASVLAGNDLFRSIMASAFPLFAVQMFRNLEKLNGPRAFPVAWGCVLLGCIGIAMCPLPFIFYRYGARIRRFSKYATSETPREANNTKGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S229</accession>
    <name>A0A2G8S229_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_10984</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S229"/>
    <dbReference type="STRING" id="1077348.A0A2G8S229"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="64"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL27830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="609" mass="65085" checksum="4E2C786068B16EE6" modified="2018-01-31" version="1">MSINNEKVSGLGPDDIHTGLPEDAIPKLDEQTFKELQAEQDAHLGVKAVEAAEKVYGRYSKWLPFLGLALASYVYSLDGTTTSNYLAFATSAFDKHSLISTILVAESVITACIGPVIAKVADVTSRATSFLGILIFYVLGYIVIASANGVGALAVGLILYTVGFTGFQLLLSILVADITTLKWRGFVSALVSGPYVVNAFVGSNIATQVLECSGWRWGYGMFAILIPAALSPLLVTLFWAERKAKRLGLVPAPTTGEAQASLPRRVWAFLQQLDVIGLLLIGTSVALILLPLTLAPRAHGQWHNPSMIAMLVVGVVLMPAFVAWESSFAQWPAIPRRFLANRTVAIAAWISLFEFFSSTLTTTYLYSFVLITKDWSLVNITYFNQAQSVALVVFGILGGLSMRFLHRAKWVLAAGLAVRLLGVGLMIHSRGANGSAAEIIWTQILQGMGGGFSTVAASVAAQASVPHVDMATATAILFVWSEIGSAIGSAVAGAIWTSEMPVKLAEHLPGTNQTTIDELFGSITDVMAYPFGDPTREGAIAAYGDVMKLMLIGATAVSGVAFLLAFGMPDWYLGDKQNAVDAKDLKGEGSDELPTYQKSDVQKEDDSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2A8</accession>
    <name>A0A2G8S2A8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09948</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2A8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2A8"/>
    <dbReference type="OrthoDB" id="3265205at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="374"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="809"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="875" mass="97636" checksum="D5F99B0C2138E7AF" modified="2018-01-31" version="1">MIRAVDILETDPTIYGEPVGQPIPPALTKLLSKAPTETVSIDVLVRQGNLHPDLIDVCPGLNISGAFLTDFRASFSRVRILTRDASTPKAQCLAYKGAELFEDDEDDVHSSLDVAFADIDVIVNTLPTTISDDVNHSVLDRNTVHPQRASTSQLPGFEPAEWQRHQAPAREARPSFRGKVIALYTSLFFELAMAHPVLGFDIANNEFTAYGSPARRVSFTSVRDVGRAVERLAILSTVPHTLAVATADADGSMSADDVRIAGATVTFEEDLKEKRAMLGVPGVSFHEYIRHSECTVVVDDECQQWPMFAQEERLGPGPSIAEDTFNDAPLNFAAPITYPLSPHPPSSAISLRPRTGHSLLCTHYFPFPLSTAALANEDRLRESCFGRRRIRVYRARVVSDQWEGSRAIAMKKIRTSDYVEYPVLLHEACGLVLARGKSSSLFKRPTDCASSADLLAAAWLDHPSIPQVFGWGRSQFYEYLAVELLGCDLATMFQSRPLTRRNFVSVVLQMFAAVKHVHASGILHCDIKPENFMLGRGEHAGRVYLIDFNLWTAWRHFDTREHLDCDEEGCNAAVGFRGTYTYASINCHLDGALSRRDDLESLAYTIFALYAGGLPWSGRGTPSADILEMKQIWQKSGALQGSCAYPLGDLVYYAQSLGFTEEPDYDGWREAFWRVDNPTAEFPECDPLYDPADDATETETVPRNMDFADWKGPIGHTYTVHFLVRSNAGRMKYAPGSNHGYRPDSSRWNRRAMTMLPEDTMEGELDIIRDFVKHISAAPTTQWESLTEGCDPEEMRGFEDPIPFRVYDEEEPEEDEEELGGGYRESAGEETVEETEIAEETDGGEEEPERWDSNDEQREGGEQREQRASQNLNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4C1</accession>
    <name>A0A2G8S4C1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pyranose 2-oxidase</fullName>
            <ecNumber evidence="6">1.1.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">FAD-oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glucose 2-oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Pyranose:oxygen 2-oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_08662</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose + O2 = 2-dehydro-D-glucose + H2O2</text>
            <dbReference type="Rhea" id="RHEA:10552"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16609"/>
            <dbReference type="EC" id="1.1.3.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.10" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4C1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4C1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050233">
        <property type="term" value="F:pyranose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012814">
        <property type="entry name" value="P2OX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051473">
        <property type="entry name" value="P2Ox-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02462">
        <property type="entry name" value="pyranose_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42784:SF1">
        <property type="entry name" value="PYRANOSE 2-OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0574">Periplasm</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="17">
        <location>
            <begin position="573"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="18">
        <location>
            <begin position="781"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="32"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="40"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL28620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="902" mass="97112" checksum="99377A2935185AF0" modified="2018-01-31" version="1">MEEVIMSTSTSFEEKCEYINGVGHCTTIVGSRHGGPQLDTPTAAPASTTPLPSSTTSTPASTLSSPSHEPASSSSTPHLPSSTPASTGSTAAAPSNSPGTDSSPATAANGTTPYPPVTPSQGTTTSATSVSDSTTVIPNTSTSNTTTSAADSLAATASNPSASGSTFSVPFTPPSASSTHRLSPGAIAAIAISVGGALLVLILGLLWYTARRRRRAPTLVVSSTSLGSHTTANLSETTLTSPAQRTLLPVEHESENEKLECSPRNSFTGSDRSVDWVDPPIDFSKASTPEGRVELSPRVCDVMRIVGLMCIVNHGLTHAQTDRIFDIGDVMFTQVPEAERTHHASKLAEEGSKIVYKPHPGYTLDNGARDKHEQHFGTGLLDHRTVYCGQKHLRALEPFLPELRAFSEFNHYDVLHNIIRYQKDIDAFVNVIKGALQPVSVPPSDTYISTLGGDGWTPSLTDVLITEGRNPHQDPRVNLKATAVTRTVGGMATHWTCACPMPHAEERVNNPIPRSELDSLLEKAKGLLNVHSDQYNDSIRNQVVRAELQKRFPGRGITDLPLGVERRKDNKRYVTWTGADTVLKDTVKDPRFKLLTETRVTRLVLNDLGGDHAVCALVRDLRNDRDAIVVAKAYVVACGAVGTPQVLYNSGIRPLSLGRHLCEQSIAFCQIILNRSTVEYISAAPQFAEKVEKHKKKYPNDPLPLPFDDAEPQVMIPYSEDFPGHVQVHRDAFSYGDVGPKADPRLVVDLRFFGKQEVKEENSVSFGPAQAPLNWVPGVTDIYGMPQATFNVQRSRADLERDQRMMQDMVTVANSLGSFLPGSEPQFMEPGLALHITGTTRIGNDPKTSVADPSSKVHGLKNVWVGGNGCIPDSMACNPTRTSVAIAIKGAASVIEYLHSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Q7</accession>
    <name>A0A2G8S4Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Q7"/>
    <dbReference type="OrthoDB" id="2803586at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1155" mass="127349" checksum="844E73DCDD6D4E61" modified="2018-01-31" version="1">MAFDPEIVRQQCAAIFEDREARIKFIETWKKGVKERADSWMDSRNGSQSRHRLVLLWIAEIVEYLVATGKQLRSSNGTDLFNALDPRWPIYGPYFEPPTYLHQMLREVTPQIEPDITYLKRCYAVHWIFHDALRRCPQCHGKKLERSGWSPSGPWEVHGLFREEMAIGIQLRCQDCARNGLPHFFSRSVVSSELFDFIVEMRLKSTSAGLAENIKSVAISVDTTFRCAYKATLVDKNKAHVRSHLGGFVSILNQKSQPISWRLCHSQSQVETQEMLSGLSTRLVCLELSPPEIMTADNCCQVRNTALKVFPQIKVVLDVWHFLMRYLMCVKDGTKNPYQGEVANNIVDAILKVRAANGVPAIYHPQPEQEERLIEAYNKWEEHGGVWMAAAAKVHATQLAHVQKGCLTCPRDDIATDGSRMEGSHKGWNSIMRAFASGLEVMNALAHDHVLRHNVRLDMQDDALDKSMFMYHTHGSHHIRLVNACAELWNRLIKGQKRGGALPANIRALPELQLVDSKETFGLMKMSSETATQYSLAKIKQEPDDDALGLSSQDMLDADRLLQEIGVDPALLNAPVVAPVVAPIIMPVVAPTAPLDTSVLVPNAPQPAAPLRPSIIDSSTEGSKVQAIKRARVDNPEDDDIIEFSPAEWGVPEGLVSRVADCRAVDKHIDNALATASLGMSAVPAPGASSISTASTSLSLAIAASASGAPTTVPPPSSTTVTSSQLVAPVSGMHAIDPTLLVSSGTPASTSDRPPPKKKVCLTITGMPPPLKSKQNGATQSAATSSKTQHKQRAQSQKGHGTLDAMFASTSNATTANGAPANGAPSTLDLTPTNEPCLPSPSIVGLTRSQRLFSVVTGVDPRSLVFGKGTSREFFLFMELRATHQWATFQMTPYDWVCAASMYNTAIKKLNHEHGAALPLKTPRALLDKLSEVETLVFGRIRDNNYRCNAFWWNQLLGTSLKVVYLGAKIQRMVDDGKFKMSKNHICGHCKRIMYPGGKNHKENHARKVCSDGVRQSAEKVHLVINGISRDFVEQPPPFLQPKDVFTNGNVFHPARFMELVRSLYDRIIVNQSAPGSLAMHDYAFAMLLKDRMVIVPGLDGRPSKAMFKLFHSFTMASGEAAVLDDHEGEMCLRMDCLSEPPLETMPDDRQEAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S539</accession>
    <name>A0A2G8S539_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S539"/>
    <dbReference type="STRING" id="1077348.A0A2G8S539"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="67"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="211" mass="23899" checksum="98232CD684E347C4" modified="2018-01-31" version="1">MSRSWECALALRRAASCRRQMSIPMDPKQITPRPELLPRRSTEQWNKQDDVLVQHLNNIFSPLQFPPELASRILTHASHPDATRRHNARLSFVGRRVLQSYLLMFIHSSPALRPDHDFEKFISHALNTYTLGELVAPKWELGKVTKWKPMNVGSLSRPLGPDDDIPSPFADVKADNARSIEGSMQGLHAGFHEHALEVCEKMGGRTGPLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5J2</accession>
    <name>A0A2G8S5J2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5J2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5J2"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="68752" checksum="7483298A5BBF3953" modified="2018-01-31" version="1">MTPRPELQDLRQRLRDIYAAMATFGSARLAAKPPILDLSMDLSGDASEEFHSHQDAVQGLRALRDAVRQDLDVLEKFLNDPACKTAPPLSTNAPYLISVWNEVLHARPPIVTIWRTFLEGDQQSHVPRRGSRKPPGVKVDVVAEGDPVPSTKNSRLLAEFREIDSYQTESEDSEDEGEVGRPSLAQKEFDNSILRIGRSLLDAAHRNPLAGTNTVPSITLRLTRLDPSPSDPREHDPRIAHTLDLLRGMGIDVELGERDPVQLPRVVAPPIRHLEPTIRLNLDLSILIALVSDLTHSSLPTSAVEADARYVPSVQYREWKRKRLEATNGPDEEIDEGRLGENGLGKHSRALANQALQEMNRGLLHELRDRLAAVASPGLANVEFWTTPEARDRCLRIVLSKIGGRNEKRRAAALFSGEDTPLSEAEEQYWAGSRYPRVFLPLIPIRVFDSSVPGAAIKPPARSDDDRALSPFFEVLARTCRDILAQETIPDPRTLSNPRSSRTPPAAGEFGEGTSTPDEDETAESEIERAAVTKANPRLTAHTVQSMLWGAARGWTTLTANKSSVKAILRDIRAGEGGGGYGWDREVHDASRTDGEGGAAVEKAAMWVVDPRSLAEGMRSDYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5Z8</accession>
    <name>A0A2G8S5Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_09224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5Z8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5Z8"/>
    <dbReference type="OrthoDB" id="2758211at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL29175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="565" mass="61927" checksum="B07DBA7ACD2EBA6B" modified="2018-01-31" version="1">MYAAFQTKDHVFIIMERHCTILSDPTIQHQLSLRSPSRAGASGLGPFPNSISLPTAFPTTLPHRGPLDSLRLLSAELFLGLSFLHIQGIVHQDLKPANILVSADGHAVITDFGSARLKPLSPPSRSAYLEGFDDFPDFSSNAAWKTRSQTTACFGPIILSAEEQVSFTRRYAAPELLHAPAWMGGRNVLVYDERVDYYSLGVMLRELALGDLAEDSQERWERASDGASRSGASGVDPVFMSFTDALLAYDADDRLHGAVVKTHAFLEPLRATWDDIAALHHPPFVDVVWPDLDPDLSLDLRAYTHTGSPDTFAVEDNAKTWSVELADIPYDASLSPPSPTPPRSYEKLPSALVAACGEAAQPTSLPSHERLSFLPSIATLDSSVLGQFPRVHSSPVIDVEPRRKAAPLLRRRQVVYDLRKAFQFAYIVEHHPTHSTSGLDHLVPTQQGSPSHDQLAAARRAQLGDGGKRQVARRELAEERIAACWSFEHEITLALLATMDSCKSMTTPQTTLQPSELGQSGRPRGTTGGGGLFVDGDARVRRIDAEKRSKGWAIFRKLKAMVRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6M7</accession>
    <name>A0A2G8S6M7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_08374</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HARBI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6M7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6M7"/>
    <dbReference type="OrthoDB" id="3246760at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045249">
        <property type="entry name" value="HARBI1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22930:SF85">
        <property type="entry name" value="GH03217P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="9">
        <location>
            <begin position="231"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL29432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="468" mass="53738" checksum="9A298F72A0E2F46F" modified="2018-01-31" version="1">MLDDLSLDGMEEWDFDLLDDFSGEDGDDEAEEDDDEDELEDEDEDEEGDTMVQEVRGPAAPPPSRLGRHVQQAIGQMYSSHYEAARNTLPRGPAFLSHVLHVYKQDRPDKFREELRVSPSTFDRLVSRLAEDPVFSNNSENPQMPVETQVAIALWRFGRYGNSASLQHAANWAGCGKGTVDLVTRRVMTAVLRSSFLEEYICLPTEEEKAKAKEWVESHSCKAWRDGWCMVDGTLVPLDERPFWYGESYFDRKCNYSLNVQIVSLPNLRIIDVGYGYTGSTHDATAWRQTKMAQNHADILEDGEFIFADSAYPLEIFLVEPYKMPEREEPDNEVFNNHISIVRIRSEHAIGFLKGRFQSLKGLHVRIKDARSHKFATYWILVCIALHSFAMACEEEERAERGEDSEEVDNDPFIQEGLSSTSESDNNRPPVSVNRGGTRVQAARVRREELKEALFRDKEKRAERRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6T1</accession>
    <name>A0A2G8S6T1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6T1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6T1"/>
    <dbReference type="OrthoDB" id="417125at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="1">
        <location>
            <begin position="78"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="366" mass="41293" checksum="83380AF52484A0E4" modified="2018-01-31" version="1">MSRSLAYEYTAPPLDANSAALTVLERRHVPELAELDQLRRKGWRDEGLDGHFRTQRKVADQSTHASEVFWFEMMKKGMKEMDDAVGILPSQGMPFEFLDVCCCPGGFSSFTLNKRRSARGVGISLPVSSGGHSFMLEDYLRPRYRFIEKDILEYNLAPSGVSGMPHSPDRLPDSMLERFQLVIIDGHALRTYAYASPGQPSLNDAKEAHILYRDSLHIAQLIVALECVRPGGTIMMRLSHVEAFPAAHFLYLLDKLSDELTVYKPRSMHAYRGTFYVVAKGICRRTPTLLELKARYVAGLRQLWFALRCGGPDGRGRRMSCSDLDFIVSTEEILGGYLDRLIELGRPVWRTQAEGLHGFFAKKGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7P2</accession>
    <name>A0A2G8S7P2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-galactosidase</fullName>
            <ecNumber evidence="9">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_08193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="9"/>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7P2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7P2"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013849636" description="Alpha-galactosidase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL29754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="483" mass="51207" checksum="126A0A14BAA5B7F2" modified="2018-01-31" version="1">MAVYVHSRPLVAYVLGALLASVAAQSEYGQCGGIGWTGGTTCPAGWVCTDLNPYYSQCLQDTSGGTTTAAPTSTSAPTSTSTSVTSTLTGIAASAPTIGPSHDVGKLPALGWNSWNAYGCNINETKVLNAASQFISLGLADAGYEYVNIDDCWPLTARDASTGRIVPDPSKFPNGISGVAEKVHALGFKFGIYSDAGTATCAGFPGSLGNEELDAATFAEWGVDYLKYDNCNVPGNWTDASTPPGGDWYNSNSAIRYRQMTAAMNDTGRPFQFSLCIWGNANVWDWGARVGHSWRMSGDSSASWSYITSIITTNVQHLDSIDFYSHNDMDMMEIGNGALTIQEQRTHFAAWVLFKSPILLGTDLALLNSTQLDILTNAELLAFHQDATIGTPAAPFAPTTGATIPSLPEFYAGTSSKGTHVFIINTNSTATAMTFDFANVPGLGSGSFVVHDMWTGKDLGTFKTSYSTTVDTHDTAALYIEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S911</accession>
    <name>A0A2G8S911_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S911"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="15082" checksum="2FA9A02A95960089" modified="2018-01-31" version="1">MFQTRSQSHEDARAAFPDLAQYLVVKAACYADYKDSLHQLPNDLELEECANYLSEWPNVRILNQWQLRELDGRPWEPEVALELAVSSAVDLVAAWRPYVDVARTTERRSWVSWCLSGEHLLAVDTLRRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S921</accession>
    <name>A0A2G8S921_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S921"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="133" mass="14452" checksum="92FE68324B779C87" modified="2018-01-31" version="1">MIPKSRKPKEDGNGSKPVKTKSKAKDTTSSPPRSAASRFRAPDINTHTSNDEAVEAESTASKKTTKTETSTKPVEDSSSDESDSKTSDDDEERSSSPSSGLEDLEKKNPGALKVKFESERPAWIDDHSQIPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Y4</accession>
    <name>A0A2G8S9Y4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Y4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9Y4"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="312" mass="34075" checksum="68951C7B6AE82B79" modified="2018-01-31" version="1">MSFALQSRQVGFRPTAHPAQTQQYQQSQPQPYQQSQPQPQQPQQNNAGLALPYPSNPYLPGPPSLALPGPGPVYPSQPQPTQTAQPAQSQPQSQSPTTASPTNAVAGPSSPPSAVPATPAPLTLEQQHITAVDGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVVTGAKSEDDSRLASRKYARIVQKLGFDAKFSEFKIQNIVGSCDVKFPIRLEGLAYSHGQFSSYEPELFPGLIYRMIKPKVVLLIFVSGKIVLTGAKVREEIYTAFNTIYTVLVEFRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA30</accession>
    <name>A0A2G8SA30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA30"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA30"/>
    <dbReference type="OrthoDB" id="2757990at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="245" mass="27201" checksum="756D4C27FED80899" modified="2018-01-31" version="1">MLDGFLLQQEMPKSSLANPQDFREAHEWSFRSLAKTIVLKHGGIDPQKLLSLLVVPVAAMGVRERNRARTFHIHSYGLDVLDDIFASNPPAVAEWTALEPRRKTVTDAYRWHPNYAGLLPVNVSVYGLNLTFVEFLPQFRPSSPTPLLADGDAKEALLENILALAMGSINAGIPLRPVEGSGPEGTLLALPGRFVRGESGSWTWRALFSTWEEYTRGEHGELDNLLDSLGFRHTPAEIMIAFNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA72</accession>
    <name>A0A2G8SA72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA72"/>
    <dbReference type="OrthoDB" id="3259206at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="348" mass="37550" checksum="2D577064EE4AA115" modified="2018-01-31" version="1">MREELSSFAWWKLVIQASMGSTGRQIDRTHQSFFVPFPLDVAEEAAGLGGFSEGVDGQVNTLALDVLQNLALDVGGTMVEISLSSLSFGALTILSFTSVYFLICRGSAAPTNAKILILGTVVLYVSTAIYMAAFIWAWSNAHRLVSRANQGLFSPTYDGRGDLAAFNHALRQQSWMMTVALGVNFVIGDATVWWRVCVIWQHKSVNCVGLLLIFVIVYQVETLTTQDAGPLPVFTTVAADFTYGCLVPIVAIYPAIIIVLVALKRSPIDNGELSRARQAVHGRSPETADVGASSTIVFRRSTFCGSASEEMEVPTNGVPATDCQSMHSLALETSTSEGETKDFTGFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAA6</accession>
    <name>A0A2G8SAA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_07375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A2G8SAA6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAA6"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="5"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="889"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="889"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1205"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="920"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1082"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL30700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2225" mass="238461" checksum="B272A92A971C770E" modified="2018-01-31" version="1">MYANQTKIAVVGIGAQLPSGTSSSTNFDYHSFFEFLLQKGEAYEPIPKERFNIEYIRGNATGKILADTGVFLKDIDQFDFLEFGITAKDAKYMPLSTRKLVEVTFLGLRDSGIDYRGKNIGCYMSGVAHDFYNISGHDDTEAKGSFSYGPAMVANRVSYHLDLRGPTVPIDTACSSTLYTTHLAVQALRNGECDAAVVGGCQLNHRFTDWLIYTQGGILSPDGKCKPFDATANGFGRGEGAVAIVLKPLEDAIRDHDHIYATILGTGVNSSGSLAPISAPVASAQRDAMRRAFAQTDRKPQDVDFLELHATGTASGDPTEANWVGAEFKRDDELALGSVKGNVGHLEITAFLASLCKVCGIFETGLIPPNVNFVTPNPSIHWDEYRFRVPTEIEPLKVRSSTRPALVAMTSSGIGGANGHAVIEGPPVSTSSTPSFWVEGAGAPSLLIAGGLSPRSTAAVGESLLGILEGVDIAGLSKVFGRRARSMTWRSFAVAKTGKTPKFNEAAIIPKHKTPIVFVFSGQGTQHFQMGRDLFRTSAVFRASIIDLDKVYKAATGSSLIELGLFTETVTDTKDPLGDPWPIAITLPALTMLQLALVETLAAVGVTPDIVVGHSAGETAVLSASGSGSKELALEVAIARSRAMALLEQASGTMAAVSCSPEDAAGFIAEVHAELGEGTLTVGCYNTPGAVTLSGTESHIDLAVKKASEAGIFARKLRTRIPVHSGMMVLCRAEFEKLVQDVFARYPTSAPTVETYSTKTGALFTEAFDAQYYWDGTIGPVRFTEAITALAATHKHATYVEIGPHPVLTSYISSMTEKNTLITCPLRRQRAPEPGAEAAEFLTALGKLVVAGHNCVNFDALTGGAKLAPGKVPKYPFAPKTVPWRMQTAEIVRQVQHRNGPLNYPQLQVNVQTHPDLADHIIKEEPIMPAAGFIEMAFEFGATEVFDVEFHSLLPLSSERPVPVEVKLEGTRWSVNSASSMDYSMAWPVQYNRRHATGFLSLEPIDQSTVQSVDLEAIRNRMTAVDMNGDSFAQFGPMYRRIQTCYVARGPNGAVEVLTQVRGADSDIPNLADYRLHPAILDAAIHVMVHPTLTGNYDSELYHLPSKVSSIRLLRAGPLPKTVYGYATLVNWSPDAITYNAMILDEQGAPILDLTGIDVVLHGHHVKALLARYEVVYQSLGLTVGAPHDAPILSEALQLDISRDARPASGRSGSTAPSGSELGSLSGVSASPPLDNHASAIVFDYVRGEETKLQVTLSTLDVSETLSLLFVAQGALNSDAVLGFTRALRREYPSWTLRVATFDSSWSLARVAQASRELLSQAGKEVELKVDVDGSVLVPRVELADPPVTHVPLSLDKPWTLENGEVVQIDLPRASEDHIVVQIGGVVSCSAGIWQFVGKVDAYGSSVPVVGITTKSISSHVEAHKGSIVELRSGSTSLAVPPLVSSTILALALSPPAFSRPERLKGARVLIHDPQGDHGAHLCDICTSLGLKATLIDSLEKANLAPSYLNKPHFILSGSREKKDVTILRSVLSAGSGRILFWNDPEDGLAGIIAKEPWVIGDALRASLKYYSTRATPSASIVRPAQLLPSETSNASLSVSLFDAQKSYVLIGGIGSVGLYMAHWMYKNGARHITLTSRSGPSTLDRVGDWVSQRILHYLRTLSDLTLQTPGVDATSEEAMATLLKNVSAPLGGCVLMAALLNDRSFSAHTQESFDVVFPPKVQAFEVLERVVDISSLDFLITFSSISGVFGNPGQTNYATANTALAGMTGKYKNAFSIVSPAITHSRLVSTTDGSHQSRLRHVTAWGMSTRELCDYIGDGIHKLRDSPVWQYVPAFDWRGVRDNMGPSPMYDHLVPDDGNDFAAQDGDANSLMKIVCHILDMKEEDVSPDVPLTSYGLDSLSAASLSFALRPIVAISQLQLLAGLTVKDLLVRVEEAAEAATPDQPAVSAAPVVGKDPAAEKVQAMEALLARLSTDLAPSTAKGPAQREALGAIVVTGTTGSLGAHALAHLLENSGFKKVYALIRPGDDGVSATERQVSAFKFRGLDTSLLESSRFQAVTCVLEKPSLGMTQDVYQEIRPSVSHILHLGWPVNLLTPLSSFEGPLMGLRSLINLAKDAQEFGPVTLLYGSSVGIFRNYKETAYPKEVPIAASVAVGAGYTESKWVAERFLEIAAERKIVQSVVIRIGQLSGGANGAWKLSEWLPSMICASAALECLPQGQGVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAJ5</accession>
    <name>A0A2G8SAJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAJ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAJ5"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="151" mass="17246" checksum="F4F2B5FCC88FEA85" modified="2018-01-31" version="1">MPRKPKTIPGPSRLSRVLAHLTQEPRPFLPNLKSLKLTYAYRNDHFGARHFVKEDLPRIQYANPAVNIQVNKLDRTKIDSWKPEMIVETKNGVTHKVNMEGKWSTAIYNELMELTAGSWWQKWKQQESSAGHLATRIPPPPKKTGASAVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBF9</accession>
    <name>A0A2G8SBF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBF9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBF9"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="138" mass="14470" checksum="79D47F6AB14D111A" modified="2018-01-31" version="1">MSSRRDTTLSADAPAAVGPYNQAIKVGDLLFCSGSLGLDPSTGKLVEGGVEAQAKKALQNLKAVVEAGGGELGKVVKTTVFLHNMDDFKAVNAIYAEFFGNHKPARSAVQVARLPLDALFEIEAIVRVGMLIEPSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBH3</accession>
    <name>A0A2G8SBH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBH3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBH3"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="276"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="433"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="549"/>
            <end position="552"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="648" mass="71943" checksum="D19E4BEE3D5BA528" modified="2018-01-31" version="1">MRAGSSRGTGPLPPDPRPLRGLSDHDPFAALLQPPPNETEEQRTERLRQEEEARKRSENIDRMLRHDEKSRRRKKTVKVLLLGQSESGKSTTLKQFQLLHTPAAFHKERIAWRFVIYLNLVRSIRRILEAIAPEDNGGLDEDDFGDSSETASIIIAAPGNLPASSLANQQPNYEAYRRRLAPLLDLEQRLIGVLSDPEDNEEATRLPFSMTALGSALMSPASSGSSSSGTGSSSGIGSGAWPTAASSSSTAGTPTYAYPPSRPPPITIPPVPPSPLGNSSSSSHPHPQSQSHSYSRSSSYASSSSYPGTSAAASPRSPTSAAPSLGSGQGHEHEPAIRTGSNWKKHFALGKMQSPKSAHSGSGELEGWWEDPNDPVHMLNRCAGAMTELWRDGKVRTRLAERRIRLEESSGFYLDEIDRITAKMYFPTDDDVLRARLKTTGVVEHKFTLAKNSEFRGVEWVIYDVGGARNQRPAWEPYFDDVNAIIFLAPISAFDQQLAEGGRMLTAERVVGWHYQDTKVNRLEDSFMLWKSVVESKLLAHVNIILFLNKCDLLQKKLDSGVRLNHYMPSYNRPNDYETVSQSYSLAWSWNTDFRNRFGAMHQQLTPNKSRELIIHLTSVVDTRKTHMIISNVRDMILTANLKSSSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBN7</accession>
    <name>A0A2G8SBN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBN7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="82" mass="9049" checksum="2D0438B1281E5010" modified="2018-01-31" version="1">MVESPALRLYSLFEVVFLVSYGLNKPENQVLLAFAQAGGRAVLGSLSQWLILAGGLRQQVLTYLIIHRVAEGTAWSKNTMNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC66</accession>
    <name>A0A2G8SC66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC66"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC66"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="28186" checksum="7B87327CEBB8570B" modified="2018-01-31" version="1">MPTEPIVFYDLPSKVKGTSWSGNTLKIKFTLEYKRLPYKTVFVEFPDIARVSREIGASPTGTWPDGSPKYTVPAIYDPSTKTAVADSMVIARYLDATYPDTPRAIPEGTEAFHETTMVAIRTVIGPHSGPLVMTLVPPLLSPDSGAYYSARVESMLGESLMKELSVVGSAAREERWMTLESAMGKLAQWIEVDGKKRKFFMGDMPCFADFIVGAGLVAMKRVLGEDGKEWRRVAQWHGGRWARLVAALEELFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCB0</accession>
    <name>A0A2G8SCB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCB0"/>
    <dbReference type="OrthoDB" id="3228420at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="162" mass="17634" checksum="0E78016A50A67545" modified="2018-01-31" version="1">MAGTEALAQHPPAMKVAGRRLSLNSRPRPPTTTLYVIPPANAGGIYCGVLTIGVPRPKPKPQTRPKSKHSDAPKTSPPPADTPPDYPRPAAPGEQQVHHHQQQQQEEEVPKRKHGSGGDEHERRIQESLYRKAEQNRPKKELSTGPKVANRISQPAGKTLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCB5</accession>
    <name>A0A2G8SCB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCB5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCB5"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="948"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="956"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1011" mass="109498" checksum="306362E27C6DE885" modified="2018-01-31" version="1">MSHTHDIDNDDPFLLLDPYEPLAGSRRLKDGVREPQHPPSSSHDLLPSPSSSAPVLPLDWYYEPLPPHTGMADEPSSSPSKGKGVSQPLYIQGREPTDVQADTFQIIGSSSSPGSPSPALAWPDPSPSVVNPSPIQLANYHDLALNFNIAADLYDLENVGESSAYSAKGKGRDRPPVLPPLELMPPSLDYIDAQWASSMSSVSMSPQTAGPSSYGSGFASIAESARGTSHDVTPPVSPEVSTPLEPVSNRRRTLSNVSIRSTRSLSALPINRVKVKLATSKGPGHIARKLLFRRRQNTPTPGSSSASTPAPIDPGLHGSNNCFLPWARDLKSCTSPPQGTLVDIDVDLSGGIPPVSPLYRLGPAPGSAMLRTKGRSYSSPFPLTSSPLDIVPITPTELLRPVPVNVPNYFDDCLPREVRILVLAALVDLHDAEHRRAVASGKWTAFRAGQARNRHVGAEKGVRELLKLSRVSKAWHSLVYDGQLWARLPKLPLTVLARLCGRAGGFVKRIEFAGLADLDADKLVDMTDGLCIEPLHTAVLPHTRITTINLQGCTALDTRSLHYLLIRSPALETLNVRGLSAVTNRTCAILSIHCRNLVSLDASKCDGLDGNGISCYASSALERGERLPLKVLRLTWLSRVTDDMMHNLGRAAPGLEVLDLSYASPFHNSAVEAFVSLTEEEAETGDFDAVQLTAREAGRDPADPNRYWRRVTRLRHVAFSSCVLLTDHALSHLAHAVPRLEFLELAGIGPDLRDDGLVRLVETTPYIRRVDLEDASDITDAVLAALTPSAPPPSAPASSHLTHRAPPPQPGHALEHLVVSYAGELTNDALQALIRHCTRLRTLEADNTRMNSGTMRDFVRLARERALADATLVAIDCRGVGEHAVKDVAAHTRPRKGWRAWEARRLGYLDGRDEEKLGVGQDECDEGRVVLKTFYSWQTVDAVRAAREKRRKAARSQRASGSGSSSASGTVMEADFATGRPRWWASTPRRSGAASPLLLDPGEGREGCTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDC1</accession>
    <name>A0A2G8SDC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycine cleavage system P protein</fullName>
            <ecNumber evidence="7">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06464</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 7">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDC1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDC1"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000097">
        <property type="entry name" value="Glycine cleavage system P protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000005">
        <property type="entry name" value="Glycine dehydrogenase (decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000007">
        <property type="entry name" value="glycine dehydrogenase (Decarboxylating), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00711">
        <property type="entry name" value="GcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003437">
        <property type="entry name" value="GcvP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049316">
        <property type="entry name" value="GDC-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049315">
        <property type="entry name" value="GDC-P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00461">
        <property type="entry name" value="gcvP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003346">
        <property type="entry name" value="PRK04366.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773:SF1">
        <property type="entry name" value="GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="GLYCINE DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21478">
        <property type="entry name" value="GcvP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Glycine cleavage system P-protein N-terminal" evidence="8">
        <location>
            <begin position="52"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="825"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR603437-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1009" mass="108980" checksum="5A510850079323E8" modified="2018-01-31" version="1">MAALRNLFALRQRPFTPHARTPHVGSLRAPARGLATAKAPPSLFASLDTFADRHIGPDDKEVAHMLARLGYDSMDAFVADTVPEKIRSSSTVVSDESIPSLTESQLFLRAKELGKANKPFKSYIGMGYHNAVVPPVILRNIMESPAWYTPYTPYQPEIAQGRLESLVNFQTMVMSLTAMDIANASLLDEATAAAEGMIMTFTGSNGKKRTFFADIGVAPQTIAVLQTRAKGFGISLVVGDALKDLDSEASRKDLCGVLVQYPDVNGAVKDFSALAKSARSTGALLVCATDLLALTMLKPPGEWGADIVLGNSARFGVPAGYGGPHAAFFACTDKLKRKMPGRLIGLSRDAHGKPAYRLALQTREQHIRREKATSNICTSQALLANMAAMYAVYHGPVNLHRIAQKVHGLTQIVKSAVECYGYKAVSSQFFDTITFDVSDAVKDAEAVHAAALVAGINLRRIDGKHVGLTLDESAGVEDVVALINAFAEAASQPTITPSDIIPPPSLAIPSSLRRTSKILPHPVFNSHHSETEMLRYIYHLQSKDLGLNHAMIPLGSCTMKLNSTSSMIPLTWPEFSSVHPFAPKDQVKGYWELIKELEQDLCKITGFAACSLQPNSGAAGEYAGLSVIRAYHESRGEGHRDICLIPVSAHGTNPASAVMAGLKVVPVKTHADGNLDLEDLRAKAEKHKDNLAAFMITYPSTFGVFEHGVQDACKIIHENGGQVYLDGANLNAQIGVTNPAICGGDVCHMNLHKTFAIPHGGGGPGVGPICVAEHLAPFLPSHPLVATGGDNPIDAVAAAPFGSASILLISWAYVKMLGGSGLSEATRAALLNANYMAHRLSSHYTLRYKNGKGRVAHELLIDLAEFDKAAGLKVNDFAKRLQDYGFHPPTCSWPISTCMLIEPTESETLEEIDRFCDAMIQIRNEAEDIITGKQPKDNNVLKNAPHPLSVITLSEEEWNRPYSRQTAAYPMPWLLERKFWPTVSRVDDAYGDLNLICDCPSVEETAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDS3</accession>
    <name>A0A2G8SDS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDS3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDS3"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="292" mass="32711" checksum="85695D026D9828A9" modified="2018-01-31" version="1">MADSSALDQNLYGYTPSRAAGYIFVIMFIMTTLFHLFQAIRSRAWWLFPTLVIAGAAEVVGWVARAKSSYDPNIRMAYIIQTTVLVLAPTPLVAALFMGFGKVVRRLGSEYSRLSPTWYSRFFLTIDIFSLFIQGGGGGMAAQGSNDPDKARLGSNIILAGLFVQIISMSFFAFLMAEYTWRRSRNQPFHKGDYNINQTPQAFDSQMKKLLVGIVIPTVLVYIRSIYRIAEFADGFNGSIAHNQTLFIVFDAVFIFLALVTLNFNHPGILLQATAQTQTYALTNTDQRPLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDT7</accession>
    <name>A0A2G8SDT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDT7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDT7"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836166" description="Berberine/berberine-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Berberine/berberine-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="11665" checksum="3861E154C03B89B4" modified="2018-01-31" version="1">MGLNPAWRSALLHTIFSTSWAEGDAIDSIMGKVNQNMITLRSLAPHSGAYFNEASLVEPHPLQAFFGDHHVRLQQIKAIYDPIDMFVVRGGIGSNEWDAELVCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFT3</accession>
    <name>A0A2G8SFT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFT3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFT3"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013987122" description="Hydrophobin" evidence="6">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="117" mass="11938" checksum="126ACA43C452A464" modified="2018-01-31" version="1">MKLLATLTAFALPLVVIHPNVVFSLPSRRSLPSVSECSTGAVRCCNSVEAPDSPKLAPILDALRLTTESDQYVGLACDPVPVGSVGGGPSCNAMPVCCSGNDFGGLSMGCSPVSPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFZ8</accession>
    <name>A0A2G8SFZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFZ8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="94" mass="10268" checksum="1979C58D2628C12C" modified="2018-01-31" version="1">MALQGIQLVGEVWMKNQDESMGGVPTYTIAGASKCPPNEPSSPEVVCNGQHCCYQANTARLCASQARYTTPVHCWAVTRRSFFRWTIAAGPFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHB0</accession>
    <name>A0A2G8SHB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHB0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHB0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="362" mass="39153" checksum="7D41A26E2B99DF96" modified="2018-01-31" version="1">MGTPPPSNAENTNRRKETTQKKAKAAAGCRQGARGNLAPVITGPPPTPPRKKAKGKHGRDEDENDEESEEPKKKKTSRRQGCKAGSSSRGSSSHTPSAKVASPSQPVSPDVFENALAAFKRVQSSGVDSDDLDLGEDGSGKPPKNIVKLIFEESLEEEEGKDEEGAVDEDEDEDADENDAEGEGGDGNEGRSCLVEIYETKRCTPEPIAYVATLWQGDTSNRSGHRFRTAVHTILSVDFDAWKHHNGSVNVDIDSDADDDIDIFGSQWGDPETPVIHDPFNLDDDDGGNIRQRILNARKAELTRYQGDRTKAKQRAKAKQRSPSELPSPSSRSLSVELSEGPPPSDLAENGDRNGDADMVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHT1</accession>
    <name>A0A2G8SHT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHT1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHT1"/>
    <dbReference type="OrthoDB" id="2749745at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="485" mass="53290" checksum="E4B1B58B9AFF6E9D" modified="2018-01-31" version="1">MPPGPKENIYRQHREYLATQTQQTSKSKPGKAKTTAQQAANTVSTATTNKRAGDTQVAPDGVEVKRRRAIAAGGAPPPDPDGNPPPGVIDEDDEPEPVRPKNPAWASAVWALDANASDATRTTLGYRKIYVAVRLLLRLCSEYAKHAHILAYGIKYHTASAEDRPGCGQDAYNDDVEAEELWPLWVKYFPELEDHLDYLADNPPLIFNIANFAAGVASKVRSDDLGRINDRIVDLCAFEDPRLLNIKDNRGWQDSRTGRLLCPLRYLQKFDSDPGRFCTNVRNRLVRIFSTDYPSFLYDLSLVNADDPVAGFLRGEVLVNVYKSVMTGKSSVFQASGRSTRGQKSVAAVHKMCQVNLHSIIYVALLARSALGDNEWSDVDGKFWKAENFVSSVAEIAWTFPAWYDEIISWWNRQIFGDDEELDSDAERDLEGTAFYAIMAQQGMRGASGSGTNDNDGNDNDNGNTAASGSVGGESATAGSSHATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIR6</accession>
    <name>A0A2G8SIR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIR6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIR6"/>
    <dbReference type="OrthoDB" id="2757443at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="272" mass="28456" checksum="DF056716B62ABF21" modified="2018-01-31" version="1">MPIVAENPATTHSEGGYLNTPRSCLATAESLMSHYISASFPKSRGPQRDIDGVPDMQTLSLGGSDGTGPGASGLPQRKTASPAEKIFLVSQTVVHIDLYAAETPLEGGARLLSQVPAAGTRASDGSADIPASCHVPRPIVTQGEPTMGPPGVASGSPDTCAVGQSVKPEEDPGAAATQSPQLQSGPIDRAASPNPVGNEDDEHIAPQNPRHKGKWYVVTKGRRVGVWTSWTQMSPYVTGVQANCHQSFASREEALKRYCGAKERGLVAVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJC7</accession>
    <name>A0A2G8SJC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04281</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2758848at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708302" description="Transporter" evidence="3">
        <location>
            <begin position="28"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="959"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1373" mass="145012" checksum="418F995CA05C606F" modified="2018-01-31" version="1">MSHERLNAFLASLIPLIPLLFQRGAQDIDWGDFVSHSKPFAPKYLSPPLELPEDEALANLYCHAFGINSMLGSRWLLDAISQPLKTSFPVADALGALRSHFQMDAATSSLLLWIIGLLFLALVSLLCPADIHTSSPGTIPSSCKTSAQIPSANMYPTYTSAPREFAKSESVHYWRGAFDDTFPLPPFEIALSTRFPLTPIAEEEEVQDQTTASPLSPDGAQANGMELLVSPSSSSYVSSPLSSQSPSHTDILPSVSDVLLTPSHRGVGEQCYPSFGDDTDASSIWVDFVLTVVPPSTSDLDTTMDLDSPTSSPGPAREAFLTPAVSDVPSIASSTQIAPSSRLLPAPSIGQLSEITPVEDQEEVHGSGTSPKGTDGAETSDVLVCETISVPALCEETQSAIEEPNQLPSPTRSRALSNITEITEPSDSSDSSPGVSRVEWFSGIHGRLASLDHHGLTLQETQGVADAGTTASTPEVSGESHWSLVDVPSTIEDFLPLSTSTPSLNSTVTCQPENADGSHRGDATLEVEEASCPRVPVSLDRSFDGAADAAAPELPASLLVGPASCFEPDVPSLCSSGAHVDLKEDDENGGLLDDTTALPPPAASVVDVSFKVQCWAQRSPPQAVTMDDVDQAALETASSTVSPSPVVQSCLATVSSPVDVCLPLAPPEVPDTPTLPVTDLTATVCSHGQLQTPTLVAPDRPIPPITYARRASKASGVVDDVSSLLRLWPDILIQVLVSRTGIAGQQVSLTDAGLAQLVARLDKPLPLEDDVRGERRRLERVTNGAMIEHSADRGEPRDEDQVVCEPVYVNEPISARVERNIIDTAHHRPLKHDPYIRIPVCEVGRSRSSGHVRSTTNVVLVKKPSVSAPSQAVSTMAAGPLLLPRNWDHRRAQSESIDRSPVLVAGDENRRPSYAAIAAKGVSSQPPLRAVVSNAVPNSSAVHIVPAVRAVKTEPVEVRLRTTSAPASSTSPTSRFGQADDDLGGWRKGNRWSALVAPTLAELLMSNGKGKKRPREYSTRDPRDESPEKRWPQSRLLKTPTQVPYTSVGKASDAGATWPSLLSSSKENGSGSSDSSANGMRGSMLSATSRVKLRDLALSAQQNSVAPRLVPASSPSNFGLGSGASPGSGAVSSSSGPGSSSSTSATIVSPGATCVPTSFAQPELVVVDADEALVKRLPQAALPEAGADLLATSCAAQTCRDGILPLESVLLLPDCSTADVRSSSLDESVDLVIASQECRPPSPTGDSPVVVRLNATSSPMVPSFSFGLGNHTIPAINWAPIGRKWAPVPPYRTSVVPPSRHEFSFAPEGVAVPKMPTLGPTPGFDLAGPRTEGGDRPIRPLSSHGEAMSAAFLEREQRAMRDDWLAWWGRSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJH6</accession>
    <name>A0A2G8SJH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJH6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJH6"/>
    <dbReference type="OrthoDB" id="2758485at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="241" mass="26621" checksum="1ED4069ACCD8794A" modified="2018-01-31" version="1">MLFPTTTHPGRQRSSVSNAALGRPSRRTVFVYSSNAGYARGTLRTLLVGGLRTFSGDDSAKMGYTPRTFRDNVLFPYHAKLPGWPSRIRFCNLSARGAPSPAEMLELIHLIRTGVLRFEEATPDDILAAQLDVANAVPGTLFHAPLPNVARRDIGSRKPRFDENGEVIPPRYERNGPKSAAWIDEEEGGEDAGERAGLRPITMWKDGFRCVLEGGSWSVMDGADGDEEEEEEEEDAISDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJV8</accession>
    <name>A0A2G8SJV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MCM C-terminal AAA(+) ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJV8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJV8"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059098">
        <property type="entry name" value="WHD_MCM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23669">
        <property type="entry name" value="WHD_MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL34044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="309" mass="35220" checksum="7FACCF1120A6F7F8" modified="2018-01-31" version="1">MNDADRTSIHEAMEQQSISISKAGIVTTLQARCAIIAAANPIRGRYNPTIPFQQNVELTEPILSRFDVLCVVKDTVDPVQDELLARFVVGSHLRSHPKFDSDKEEMEVGSTLDADIIPQDLLRKYIMYAKDKVHPKLYDLDQEKLSRLFADLRRESLATGSYPITVRHLESMIRMAEASAKMALREYVRGDDIDLAISVAVGSFVSAQKMSIKKTLERGFRKYLTQARDHEELLAFVLGQIVKEKARFYQLQRHQQPESITVKVSELDERAKEHDIYDTSPFLRSKLFAANGYKLKEGTIEKTFRQGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJZ8</accession>
    <name>A0A2G8SJZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphogluconate dehydrogenase NAD-binding putative C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJZ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJZ8"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="66"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="264"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="38712" checksum="32EC10763E5D5B76" modified="2018-01-31" version="1">MASRSFLRALSTTFSLRTQSATVTFPSGGLVLITVSSRSSTTLATLPPTPILNQARTLLTMPSPPTIAVIAPGAMGAAVASRFTKAGCTVLTTLEGRSPSTVDRAKKAGMEDASLGDIARRADWVLSIIPPSSATAFAEAFKKAYETSGGNPKLAFADCNAVSPDTVKSIARIFDGSPIRFVDASIIGGPPTDGYDPAFYASAAPEDEDALDAFVGLSAWGLRTIALKGEGAGVGDASGLKMAYAGISKGFIGLTATMILAANASSPATAQALMHELHASQPFILERITRSIPSMLPKAYRWVGEMEEISAFVRSGLGDGEAHVHEGFAHLYDRVEKALPEGEDVAVLKRFVEGAKATIHESGGSKSHKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK37</accession>
    <name>A0A2G8SK37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK37"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK37"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="201" mass="22477" checksum="49C3A660211F508A" modified="2018-01-31" version="1">MHSRRVDLLQLTAFSCGWQFHWQDYSDTNYLKALHHLKDLQSEGKIELIGLCNFDSAVMDEICTELGPGTIVSNQVQFSLVDIRPLYAMADVCSRHNVKLLTYGTVCGGFLADSWLGKEEPDLYSGALTPSQRKYLDMITRAWGSWSLFQELLAVLRSIADKYEGMSIANVATRWVLDHPFVGAVIIGNKISVSTAVELPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKG5</accession>
    <name>A0A2G8SKG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKG5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="85" mass="9512" checksum="71AF0916D39CAE1D" modified="2018-01-31" version="1">MGGRVEEMAKEQRGEEQDAERKEEDDAQPDNALGLFWDGGPIYPYNTLAGLNKDDPGFADLQQLPTDIPNYAIPDDDNYPLPDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKK9</accession>
    <name>A0A2G8SKK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKK9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKK9"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="98" mass="11082" checksum="FD510EB911584336" modified="2018-01-31" version="1">MLDMQAIGGAHDQEAAVTPTIFVHVLVRGQVKVDLYGEINKCEKLALTKMNLSKMEKFESQPDYETTVPENVLLINDEKRKAYEASIKLLEHSIDMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKR7</accession>
    <name>A0A2G8SKR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKR7"/>
    <dbReference type="OrthoDB" id="2736021at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="212" mass="23284" checksum="567EBC21DEAA547E" modified="2018-01-31" version="1">MPEALVTLNERTIMCPIELFKSTFIFSTLRFGLLDCDGSEKRYTCCISPDALPRLTQPKTPILFSLLGQIAVKDCFMTARGCLRPPDEEPVASCWLEQRSNPVSDLTWRGILPTIKALVQEFAAGSEVDTSQLLAVGADGKLRFQVIWQGDVGESGGDLPMFDEFGTEQVPASISQVPFGQPVHAVFSIDFVHDRQAGKRTVLASLFALMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKW3</accession>
    <name>A0A2G8SKW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_03179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKW3"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL34404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="476" mass="52840" checksum="8CB66A41B76C6BE5" modified="2018-01-31" version="1">MDSPTKLVEDVEKPPLSADSASAEESEYVVDKEAERRLVRRIDMRILPAAMFIHLLSFIDRSNIGNAKVLNRDVGHSLTQTLKISNEQYLVALMIFIVAFTIVQTPSNYMLKKYRPSRWMALMMFCWGATTLLLAAVRNFGGLVALRFLLGSFESGLFPGQVYILTFWYRPEERAVRIALIVACSSLGGAFGGAIAYGIGRHLDMVHGLEAWRWLFLIEGAPSCVAAVFCALFFPDYPETVKWLSDEERELATQRIRGVASRGEDRITWAETKATLVDWRLYAHYIAYISNSVSFSSNSLFAPTIVAGLGYSGLDAQLFTVPPYAVGFVVTVAVSWIADRHEMRSLATFFSMLIAGASYIVQGALPLDAFVTRYVFLCFALSFSFACNPCSLSWLTANLRSTGAATLAIPLNVAFGQLGQIIGVYIYKDSEAPGFPTGHFTNAGFLIEGAVLIMSLRLFYIYKNNGLAPGERRWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL34</accession>
    <name>A0A2G8SL34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL34"/>
    <dbReference type="OrthoDB" id="2796825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="332" mass="36037" checksum="7B9EA5E3BC5EEE33" modified="2018-01-31" version="1">MSSLFQNAYYLAINFNAILYGAELAIYWMTMKTLFEKRKACQCSGTDKFYAAFSTALLVLITIYMSTEAVFGQEMWIVHSGDPGGPLKFFVNNANVWYQTMGTTASVILIMLSDALLIYRMHVVWPDFRIVAFPCFLYTASIECLRHHPSTFTAVAALGIIELYLSGKPNANFFVGTAAQLGLAYYATTISLNVIATGVICARLVYFSRAATSDFATPRNPIATGSVVARYTGTLPVVVESALPYSLAGVAFLVSYGMQSDVSILFGALYGMFTCVSPQLIILRIVTGEAWTREKTAETVSALECEGFPAANAALASQADGGSVDHKSVQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL61</accession>
    <name>A0A2G8SL61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL61"/>
    <dbReference type="STRING" id="1077348.A0A2G8SL61"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="320" mass="34551" checksum="9BBD9864B09C65B0" modified="2018-01-31" version="1">MEDEDRKNAQLAAHFPHVTPKIPPNMTAAPRVWFITGSSSGLGLDMTRDVLAKGDIAVATLRKPEVLSDLAAQYPPDRLIVLKVDVTILQDILDAFKRAKEAFGRVDVVVSNAGTALLSEVEGTPDDVARALFEVNFWGSTHVLQEAVRFMREENPHGEGGRIFQITSGTELVGYPACGFYSATKHAIGGLAETLAKEVDPDWNIKITIISLGAFGTNAVGAMVKVPVHPAYDNPELLVAKSRNSILTSLTGSFDPMYEVKGDAAKAAGAIYRMSLLPSPPLRVPLGCVDLARAAAKSFLDEVEQYASWSVGLDKDEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL99</accession>
    <name>A0A2G8SL99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL99"/>
    <dbReference type="OrthoDB" id="3269515at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="477" mass="51172" checksum="0A697CA82101F288" modified="2018-01-31" version="1">MGPSSVADGAETPAPARPTVAVPLNTSRRVTSPDPYSALSDTEDAVPYETIRHKSIKRAILERIRFGTLRRPDYERGKTTEDDSADTPLRTHSTTPRRGGQYRKGLRRTGTDGQAALSTDGVSTSSRQPTLVRSRSQEVVSPPGFRILVEDPTSGALLDEDVDLTPAPSSSSRRHHRTPDKFTRLPDRRHSEHKRPTPRSPRASAPKRAATGASASAASEYSFPTPSSKQRPARPVMNRFESSILLSSPPTVTSPALESQLFFGSLVSPHPPQLPEISALARKPTNHRSSTSTAAGSGAAAASPSPSGHEKQGHVQPRKKLRTQRSPPLLPFPSMVDSSPFRNRLKKPPHGQGPPPTYIPLAERADSTDSDSMDAASEQSATGSPGTRLGRGTTPAERYYARHTALERVDAILSRSWSERQEAGVESPNSLGGFLGPILGADFDKQMEKNVDPADSTEGGGARPSRAGPVMTPKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLK8</accession>
    <name>A0A2G8SLK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLK8"/>
    <dbReference type="OrthoDB" id="3147752at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013890077" description="Transporter" evidence="2">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55260" checksum="99E5E0B0F902D672" modified="2018-01-31" version="1">MTLYSTLLYLISLLRSGIAKCIQKMLRDDAPELSDLGSQKAVSVQTDLHQAETEWLRAALEDKEREMRSLEKKEQGAVRRARTFQVELETVRQRLKKFEADYAALQRRTQQTETRLSEAEDRVKHSEATVIQLGLELRRSESERQKTATLLHTRSAELRDAQAYLSKLDDVADAEVLQLVDGINSRIFQTAANIANAFQLRYAEQKDAQVSEEAVTRLRAFLGDSYLLVALRFIHHAGDPLIVQTALQACMVSWSRWLCVTWDFHMGNPPCLLQHVYQSIRRTGTYLQVLDIAPIGRSSYIDENQERQSVAGRWRALSRMYVKTLRADDAERQRIASNMLVDHITDVLIASGIGMPRQDLREKVENSYADALREVVHQSLEFQWIAGERIVSRDLFVFTALPGEPFNPSHMVDEWANPKRARHGVDTHPVLCTTQLGLVREEKKAPTEGADGEEGITKVVLLKPKVVLTSLLEELSNEQDRVACKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLX3</accession>
    <name>A0A2G8SLX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLX3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLX3"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="66047" checksum="1DF210FA6E7C5FA5" modified="2018-01-31" version="1">MDAGQLGRWTRFAAKGGIGKCTALQDCVAERAEDLMFMQDDEITVLMQVPGQVDLYLGYCEGVVGHFRGEAVRFQGRLKKPVLTKRQSTASPISRPSSSQSALTVFARDAASPAVSVVRDPPSPVVSSIHGVRTPGASASHRPALQAAQHRQSDRAPPAARPHHVPLPPVDRDSSIYSDDQSRHRISVAISDNGAGNIGLSLLQDFVGGTDDSDSEDDDSPSIPIPRVQSPESAIDEALDYADSMRSDSQYSESPQSTTLVLPTTNMLEPPLTGRSEFSEPSSQYSESPPPGPLPVVEPLSPRSPTSPRSLAMARSESEYESEGEGDWEGADDIYDQYRYSRFSMASKMSRFSKGSIGSGSDAPPMPSQRTSLESTSSGRERKESKGKLPSRLAASTTLADVDDAKEPSRTEKNRPAPLTFRKDPEPSPLLHTTFGSPQASPSLPSATSGSFGSPTLVSPVYPSNTAAAMNTKRRADVGEGEGSASRDSLRHLLVEEHEGIPLTAKSQVGEIVDEHPAARQSPPPTPAIPARVSQGSESSAAKEKRMLALSNADTDGLWRGGGLSSYEHRAIDSYVPSSYASRQPATPHLNNVMGYDTPTVILRGIARYTGISRSLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM30</accession>
    <name>A0A2G8SM30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM30"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM30"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654733" description="Transporter" evidence="1">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24276" checksum="13E139AE59062697" modified="2018-01-31" version="1">MVLNVMFAKLAIVALAAAAVSGQITSNVTIAEVEQAFMAARIVPDVIPTFAPPGLLDVVFFDDVTDTNIMVTPPGLTLTREQTAMRPTVFLTSNDTALAAPQTFVLAMIDPDAPTPENPTAAQFRLLLAPNMTLSGSLAEGAMLVNNTPAITDFLRPNPPAGSDPHRFILLLFAQPTNFSQVVQGIVNASTPRNGFNISAFAMQTALGSPVGGNFFLTGPDDTTTVRFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN24</accession>
    <name>A0A2G8SN24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IgA peptidase M64-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN24"/>
    <dbReference type="OrthoDB" id="2961863at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013634503" description="IgA peptidase M64-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="70480" checksum="065CDA0FA097F1A4" modified="2018-01-31" version="1">MNRVLLDIWLVLALCLTSGLAADVTERPYELVVHRELDTLKCTYLALRETQHFRGLADSGYFKSKRLESGEERIQFIAKEEQAVWERAEALCGEKYTWDFYTLIHTVPQGYEMEQVVLPPVQDYVPQLEVSPLITSGDSSNRVDLVFFADGYTSEEKDKFLDDALRLAEDISSNQTFYTVKPLLNFWAAFAPSKESGVGVGGKPKDTVFGLYRDGTELRGVYYSKPEVAREACDSLGTQCDYPILMGNDPLYGGLGGEFTVITPSLANGPLVLRHELGHSIIDVGEEYDGGFAYFGVNAAHNTTSAGVPWTHWLSPVPNTATHHHSHSYDDHEHNSPVEGEIRVERAVMPLQNYAWTLLNTSAAWSTTFNSSGQYAWHLIRFSLSGIPAASDLVVSLDGKDLHWAPRADIGVDRWHYDIKLNHTLLEGEHEITFTLKNTETEGEAQLCSVEVLEFGDENEFVTTPGHYSLYPTFSEMNETTYRPTNEDCLMRIVTTPNFCSACVEGLWYALLRRVALIDDLARSCSEPSTLLDVGAQSQSKQQRVLDLALVPLAHLRDTPVDVKEGYEITWVKDGVEVPEFANRTRLVDDGDALGSYAVKVRYWTEEVRVDPEELLESFAALTVLTRCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNR8</accession>
    <name>A0A2G8SNR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNR8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNR8"/>
    <dbReference type="OrthoDB" id="3222453at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="301" mass="32979" checksum="DCC1C27B9C15F0DC" modified="2018-01-31" version="1">MSGEVRIGDVGYLRDGHFCFLFNTMLGADDPVNLQQGVPDDFVVFNVPQPPLHWENEITDTQLHSKTVRSMEVAATMPMTETVASASVGLRYQCNADSGALLLLKQPAHKTVLDCPLHIKKYMMTHLASWHDFANRLGIGLDEKDIVFISGFLKATVWATAAFSNNSDSAELVIAGGCFVPAASGAFRVSVSRGVEASVASRAGPQGRVSTWTDGADQGFKYDQCIFLSYYKMKCRGMLRRPRVMRAAAGPHTLPGKHDDDDYSSPDIPSSLSTSSASQESKYVERSYDPVNELLDYILKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNT5</accession>
    <name>A0A2G8SNT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_02135</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNT5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNT5"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL35409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="490" mass="53144" checksum="8AE7F5F596554D6D" modified="2018-01-31" version="1">MGKVYNIFLAIFCAIGSFLFGYDSGIISSIITFSAFKSFVNDPGNYDSLSGAVVSTFTGGCFFGAATAGWTNDKLGRIRTVQLGVSISLWGCAMQAGANNFATMLIGRIVAGFAIGVLSMTVPLYNTEIAPPKNRGFVVGLTQQMLGIGFIVANWVGYGCQFLNGNTQWRLPLGLQLAPAFLLLVGSPFMPQSPRWLLEHGRDEEAREVVYRLHGSDAATRDEADAEFAEMQETIKAEMLVRSRSLSDLWATRGMLRRTFVAVGVQVFGQFSGINVLNYFGPSMYRALGLSAGQSLLVQGIYGAVGPITNFFFITLLLDTVGRKKPLLFGAGSFVVTYSCLTAIVASFPPDQSTNLAAQRAGIAMIFLTSIFFSLSFGPVSWVLASEVFPTRTRSIGTSVATCANWAFNVLFSQVSNIAIVNISWKYYVVFIVLNAVDFVIMALFFPETKGKTLEQMAEVFGDEVDAHGVLESSAAHEKFDHENLDSAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP46</accession>
    <name>A0A2G8SP46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP46"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP46"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF152">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="58"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="549"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="705"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="828"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="593"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="839"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="857"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="937"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="990" mass="108710" checksum="21C02539E11A6FA9" modified="2018-01-31" version="1">MANAVASSSRDRTAQPRTSLHSLHSVHQYNPNQAVVMTDEIIRRRPASGLYIKIVNQYGFKVKVGKGQHGEVFLAENVHHPGSAMAVKAVRRKNKSDRLRKLRRNDNIPRQPHLPLVDQLGSTEHKIRKEIAIMKKLNHPHVVRLLEVIDDPLNDKIYMVMEYLGGGEIKWRTASDNPLLRVDQTRRICRDVILGLEYLHYQGIIHRDIKPANLLWTADRRTVKISDFGVSTFSYAQRLAAAGKGNIKHDDTDPILMDESDLSKTAGTPMFLAPEIIADASESAYHLPLPFLPHPHRSSSSQSQTQTQVQMNASNKTPTPTQGTGTAVQVGAQTPRKKPPITKAIDIWAFGVTLYGLLFGTLPFHAGTEFEIYKVIRTQDWDVPAVMGLDRIPTGGRHPEFAAAAAAKKNGPAGRKAVLETDGAQVMDLLERLLEKNAARRITLERVKRHPWILRDLEKPEEWLRETQLTQYIPLEPTHDETSSAMSAVRFRWLPRIGNRILSTLRSVKPQRSFRRGRPRDDRDEQDEVGVRSAPHYVHVVRQQPASATIASGAATIGSPRQLGSVRERKRRSRQDLARNKSTNDIGSKPVDGSWASSPGAGSSKGKSVDTSLRIPSQSSRITSPAPSPSVGPSSMATSPVGEHPPSDHLPDGASPRSDRPQSMVMQWVRKLGGSSRMSSYSNYPSLMTESAVNLALSGRLQYRDGDGRMHPVAATSPPSRDSADAMSGHATSRQSSMSMSIGGKLSKAMRAASWTAPDFAQARPSEDMTSLYSGDRPEDLDEEVLMYGAGGVAGSPVPSVPNSALLSTVSSMHSIGPALVVRPRMDEQHPEASDHVNHCHSHSHSHSHSRSRAGISPSSRSRTTSPLAKVTYRTREESPSSGSDDDDSDENSYDSADDGSSILDHQTRGRTMLVNQDPGDAHSFEGQPSTSQMYHDEDEDSDSEEAVPLEVRTRRPSQSAADMTSPRRSLSASAHPAAQAGKQRTMICT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPG5</accession>
    <name>A0A2G8SPG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transketolase-like pyrimidine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPG5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPG5"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="323"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="637" mass="69864" checksum="0D5A0B422EBE5B00" modified="2018-01-31" version="1">MSLANAKFPIDMSKLQKLQLDPSSSKLTTEQKSALHNNIQLMRDAIVMFTTTGAARGVSGHTGGAYDTVPEVNMLLALFNTSDKYVPILFDEAGHRVATQYLASALEGALPWEHLLYYREANSKLPGHPELGLTPGVKFSSGRLGHIWPFVNGVALANRDKTVFILGSDGSQQEGNDAEAARFAVAQNLNVKLIIDDNDVTIAGHPSQYLKGYDIAKTLAGHGLKVVTVDGENVEALWAALVEVIQYTGPAAVICKRKMAPGVPDIEGSAHGHDVIPVKSALKYFQKRGYPEEPFVDILNNIKPYAFPYLYVGSSKELGANRVVFGEAVNKVLDKLTKEEAAKKVMVIDSDLEGSTGLKVIHQKHPEVFVPSGIMERGNFSAAAGFGFDAEKYGVFSTFSAFLEMVVSEVTMARLNFCNVLCHFSHSGVDEMADNTCHFGINSFFADNGLADTQSWLYFPADAAQMTAVIRRVFFDKGIRFVFSTRSKVPWILKEDGSKYFDENYEFVPGKDEVVAEGTAGYVVSYGDMLYRSWDAVLRCRQEGLNVGLINKPTLNLVDEQAIRKVGSSPFVLVVESLNQKTGLGSKFGTWLLERALTPRYGYMGTIKEGCGGLTEQIPHQGLDPQSIIKRIRELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPH8</accession>
    <name>A0A2G8SPH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_02395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPH8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPH8"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013950193" description="Cupin type-1 domain-containing protein" evidence="4">
        <location>
            <begin position="33"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="111"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="288"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="443" mass="49008" checksum="E730CB04DFE2EB45" modified="2018-01-31" version="1">MATSTSSKLVRKMLPVLLLFFLLAVSFQPVESSPTPATKDATSRSSVLYASDDPNARLWEPDSHMKPEPIRESLGADVIGPENFPLQLQNADLLAPPTTDHGDIANAKWSFDLSHNRLQPGGWARQQNLKELPIATNIAGVDMRLKKGAIRELHWHKTAEWAYVLRGTAQISTVNADGQNYVKNVSKGSLWYFPAGQPHSIQAAGDDQNGVEFLLVFSDGNFSEDDTFLLTDWLAHTPKEVIAKNFHTKQSAFDHIPGQELYIFPGIAPTSDTAPEDPHGGPPEPYSYDFANMAPTRYAGGTVKIADSRNFKVAKEIAVAEVSVERNSMRELHWHPTEDEWTYILEGNARITLFAASGNARTFDYQAGDIAYIPSSFGHYIENTGPGTLRVLEILKTDIFRDISLNQWLALTPPELVKAHLQLSDETIAQLSKDKPVIVAPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPR2</accession>
    <name>A0A2G8SPR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPR2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="101" mass="11019" checksum="F3FBDA9B071F4BF1" modified="2018-01-31" version="1">MASDGSSVHAELHAEPLKVDPNRSHGDRHHLSSTTDSQKLSEGTDDGPTKVARTAGSGIPDTGWAGQFPSHRGGDSHPDFMKEPPYSWNLISLNFKQKYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ12</accession>
    <name>A0A2G8SQ12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ12"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="118" mass="12769" checksum="CE4BC7723FE47F08" modified="2018-01-31" version="1">MERGKGKGNVMYIHYGSCSSIGRISRICRMVTVPRMSPDQRVSPSGQKASLNPSELRCSGYVATHDPSLVLHNPNVPSSSADAMYFPQGEKQASLVVLCPSSENSSTAVCAFQRFTMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ94</accession>
    <name>A0A2G8SQ94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyoxal oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_01601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ94"/>
    <dbReference type="SMR" id="A0A2G8SQ94"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ94"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013842844" description="Glyoxal oxidase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="143"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="466"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="68836" checksum="A594F8624911B1A6" modified="2018-01-31" version="1">MVRAHRTNVRALAAAISLFASVYAQTVNTPGQPSTNQAPLGQFKIVGDSIVSAQQLFLGTTDKVYIVDKVENNPTKINGHPAWAAEYSISKNSGRAMDVVTNSFCAGGAALGNGTWLNVGGNQAVGPGGVQADSQLGGGIYDDPDGGKSIRLLNPCDDGNCEWTLVAPMSTRRWYPTVETLDDGSVIILGGCLYGGYVNAAGQDNPTWEIFPAQSDLTPVVSDILSTTLPVNLYPLTWMLPSGKLLMQSNWKTSLLDYRTQTETALDDMLDAVRVYPASGGSTMLALTPDNNYTATLIFCGGTNLQSSQWVTNWDIAQYNASNSCVRLTPDVSPAYEEDDPLPEGRSMGNLILLPNGKILMLNGAQTGTAGYGTESWTINESYADNPVLMPIMYDPSAPQGKRWSRDGLSPSTVPRMYHSSATLLPDGSVLVSGSNPHADYAVDNVKFPTEYRVEYFYPSYYNQRRPEPKGVPSSYSYGGDYFNVSLTKDDLFGDVNNIKNTQVIILRTGFSTHSMNMGQRMLQLQSTYTGNGDGSAILHVNQMPPNPATFPPGPALAFVVVNGVPSVGVQVMIGNGQIGKQPTSDVANLPTSAISSGAGTHSDGSGNNVSQGGHKNYAGSLRDRMSSAAQLVATLASFAVFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUB8</accession>
    <name>A0A2G8SUB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_01058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUB8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUB8"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="30"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL37365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="301" mass="32551" checksum="7EB2EF968602551F" modified="2018-01-31" version="1">MPLGPPSSAVFIQNAAPGFTSTPGRTPTSVTVHPVALFSILDHYLRRTDAQERVIGTLLGTRSDNGEVEVRSSFAVLHSETEEQVAVDMEYHRTMYDLHHKVNSKEVIVGWYSTGSNLNTYSALIQNFYSQETAPHQAIHLALNTGVEEGQKAGVQAYVGSPVGVTPKPENCVFVPIPCELRFNDAERSGLDLLTSNLSNAANGSFTNPSSDLELLERSLVSVSEMLDRVLAYVQSVLSGEVKGDAAIGRYLMDALGPSTEDLEKGGFNSHLQDTLTVSYLANLVRSQAEVSARLALVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUC1</accession>
    <name>A0A2G8SUC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUC1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUC1"/>
    <dbReference type="OrthoDB" id="2758521at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708308" description="Transporter" evidence="3">
        <location>
            <begin position="25"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="52508" checksum="18AF42D4901D31A4" modified="2018-01-31" version="1">MFFRVSFLVLCAILRSLPFVVVRGQFVAAAARTIIAIDDTYGDAVTGIKPVYNPPSKWIQGQSCISGDKCLVDPDQKEAWSGTWHDATATSGEEPPRTIDFSFEGNSIGVYCIVPQVGRVAEAATANMTFELDGELVGRFSQDRYEATGNTGDHDIQYNVAVYQNGSILQGHHTLRIALTGDSRILFDYALYSTESDVPMSKLAPPSPTSTSAMGEQMATFQRRMTSPANRIGVIIGAAVGGTLFLIGVGIVAVVLIWRPRRSTENPRRAGILLETDQLAYREHDPFHSDRRSVLSSADSATPENDRPATPYFPFNHYSDPFLSPSSISLTNGDTDRRSVSSITVSLADSIPLAEFPTSPSINQLPYHVVLTGSETHLIGPDNSMAIFARQQMAEREAELTRRTHETEAVFLAKNGVSLSSVDAASISAGLSSGSGGSPAVGSGSIGFVAGLQIPMEEVEGGDRADENHRAEGGSTLQDGSDLGRGRKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUH1</accession>
    <name>A0A2G8SUH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUH1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUH1"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL37410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="289" mass="31804" checksum="710FA7871F98814F" modified="2018-01-31" version="1">MSTRLLLRAVGKARLSSTATRGYATATTRPTPKTTYASRTTTRTSTARASTTAEKSNAATPNDVDIPPEAYSAPPESVPSSSTLQDVSSPPTNASFVPAEFTESVTIGGSPADPNAPDWSKSYFGLSTQPFPREVAETLLAPVDPMDVEMKPDGLIYLPEIKYRRVLNKAFGPGGWGLAPRSETNVGPRVVSREYALVCLGRLVGIARGEQEYFDPNGIPTATEACKSNALMRCCKDLGIASELWDPRFIREFKAKYCIDVFVEDTRTKKKKKLWRRKDQPPFEWPFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUJ3</accession>
    <name>A0A2G8SUJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUJ3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="127" mass="14114" checksum="63F3B2A18C7E5432" modified="2018-01-31" version="1">MRRGEMNASINVDRLSCAERRMYMSSICRRGCRVPSARTSQLSLGFLHGFRSLGHHLRCASPDRFHCTSSSPCASLLDDRLWTVLRRDACGTTTGRRRRPTSRTRSSSSRRGCANGALAVSTLRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLF7</accession>
    <name>A0A2G8RLF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_15042</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLF7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLF7"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="7">
        <location>
            <begin position="94"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="190" mass="22219" checksum="BEB1C1F505529640" modified="2018-01-31" version="1">MDQHSTTAVHTRLTADFPELAHLSREDLEDLLTDPQYFQAVFYTLPQVKLLYQGQADLGSANESIAKNNLALQDHLYKLRSETQDAFDRAKQLEARWKEVEKEQREVYQRFDPQFMLMRLRHATTAQDDLSEARANAFVQGSVADPGDVPVTSKEIDDFVKEFRELRKTYHKRVMWGDRWQAGEVVWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMU7</accession>
    <name>A0A2G8RMU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMU7"/>
    <dbReference type="OrthoDB" id="2729990at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="459" mass="52530" checksum="609E025D88A38448" modified="2018-01-31" version="1">MSFSDRTTTSRLMRTCRTLNHEGAKHLFKDTLWIANEASAISFTQYAFARANLDEMAHRMHWLNSLHVYAPRPRGNEVESIQRLSRSITFFLSHFAILAPNFVELNLHDSEELLSADTALAEVIGAMARLQKLILTGAGRQTSEMLRRSNLRLWSVEFETIDETVLSMDDHPMYALHNSQDTLRVLSLERVAFDPDRHLPCYNNLVQLELATSLVPPVHRLAQAFPNLWRLKINSFPGHSHLNAIEREEQHQTNVLGQAQHGTFPSLRSYKGSILSFYLLALTCRVPFIELRDDEHIPCWDTRMLQATCAHARPAHLDLYVSYLHDFLAQTTGFAQLCASEDFRRSVGMLTLTFDVFWGEHDFDLAPVLECVYLAVRASSLRAVELILDGQHLWEDCCDEDEEFPPVEVFLQSLDIEGVADKLLEKTETLKTVIVRLWVSEKPEVKVQRGPDINYSDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RND2</accession>
    <name>A0A2G8RND2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_15523</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RND2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RND2"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="94"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="204"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="420"/>
            <end position="424"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL22828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="59905" checksum="F5DFC809DF688C7C" modified="2018-01-31" version="1">MASERKAFQDQVAQVERWWQEPRWWKTTRPYTAAEVVAKRGTIPISYPSHVQGKKLWNILSKRYAEGTPSHTYGALDPVQVTQMAKYLETVYVSGWQCSSTASSTNEPGPDLADYPSNTVPNKVEHLFMAQLFHDRKQHEERSRLSEAELAKTPAIDYLRPIIADADTGHGGLTATMKLAKMFVERGAAGVHIEDQAPGTKKCGHMAGKVLVPVQEHINRLVAIRLQFDVMGVDNLVIARTDSEAATLITSNVDERDHRFILGSTNASLRPLVLELNQAERAGRTGAALEAVEEQWTTAANLELFSTTLSNALRAQGASPAQLGQFAARIAQASYPAALEIAQREFGLRQVPHWDWDAPRTREGYYRFQGGTQCAIARGVAYSPYADLLWMETKKPILAQAQEFAQGVHAVYPRQWLAYNLSPSFNWEAAGLNTEDMRSFIWTLGKLGYVWQFITLAGLHSNGYISDLFAKAYATEGMKAYVELVQRREREIGCDVLTHQRWSGADYMDNLMKTVTGGVSSTAAMGKGVTEDQFKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNF9</accession>
    <name>A0A2G8RNF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNF9"/>
    <dbReference type="OrthoDB" id="2762719at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="17410" checksum="4BBACE69B1F5F1DF" modified="2018-01-31" version="1">MYHWDVRLDPEPTQLTTAALSLPAFDSPPDVQSFRLHFSPLASTPAMDYSCDVAVPPGTPISIGDVFRAIHRAVSAPLAGRWAHWRGDPMRRHVERAFRRRTGARADSDVLRNVDLHLHMADSDGRAGVFFHGIAVEQVEGYTVFRVVLREGPPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNM6</accession>
    <name>A0A2G8RNM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 13 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNM6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNM6"/>
    <dbReference type="OrthoDB" id="2564904at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013869942" description="Carbohydrate-binding module family 13 protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="38266" checksum="9532783380EA5FE7" modified="2018-01-31" version="1">MFRSAPFVSLALASVVFAQTYSATYTPQDAPNKSEQGQSGTNQCGTGSDQNSMCQNVYVSSLDDFCIFAPPSPGPGSVIGNTERIEVAWCVQSGHGTRLIPDGAITGAHFVQTPDYVQVTGVGDLTKINIPQGDEGGELDPHGADGNGNPIGGLVFSSAFGGMAQMHEWTNFVAYNEFCIRACKDGPKAPALCQHIYDVMGCDWNMPGDYSSGSFDSCKGDSGEPMGVYGTSTFYQGEPSTPAAHPAPSKSQCNPANTIGNGQSISTSAILTTSPASSAASGSSSVSTSSPSSVTASSTTSSGQSSTTSAAASSATSSGSSGQSMTTTRTSAPPAPTGSSGSSAGSSPSATGGAQNGAASLFSRGLEVSVAAAAVIIGAAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNU2</accession>
    <name>A0A2G8RNU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNU2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="126" mass="14011" checksum="6E51A3B5DC657C8F" modified="2018-01-31" version="1">MGARPGTRQALFSRSFYSRTRRPSENKGRRHASAHALPSARILGARLPTDRPFISVAPTPRIHLNDGTPGARRRVLVRRRFIAQRCSTSKFARAHALYSVGLLAPERVSTMEMRCAIPMPGPVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNU8</accession>
    <name>A0A2G8RNU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNU8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNU8"/>
    <dbReference type="OrthoDB" id="376826at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024:SF49">
        <property type="entry name" value="LIPID STORAGE DROPLETS SURFACE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14024">
        <property type="entry name" value="PERILIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="339" mass="36811" checksum="32898476C6F7D35C" modified="2018-01-31" version="1">MATETQQAAPAPELTILTRVGCIPLVADSINTINSTLLNNAYTRSPYTTAAEISKRALSYAEPVQQRLAPIIIRADGLANKGLDLVQQRFPYPFQTPTDVIIKDLKTHGDAARDVATKTIDERVRTPAYNIAQGIDQKFAPIVDIFAVVVNKVQPNGNPEKSPEVPKDAKFQYQRAYYLSKELSDQLRTYSTEQINQITAQSAIVQSASATAQSVTQLASSSYDAAQVRVHSLSDTMLSELRELRTSILGLPAALQSAYQDVSTNLATTINELSAILTSSDPLPEKVTKVRDTVTERVQPILDTANTRAQEILAALRARVSESKQPVANPTAPNGNGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP51</accession>
    <name>A0A2G8RP51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_14587</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP51"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP51"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013923527" description="GH16 domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="61"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL23277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="364" mass="38384" checksum="E011334E390063FD" modified="2018-01-31" version="1">MSIKLSVPLVLTLLASLSAVSAQQCNATSHCPSSAPCCSEFGFCGTGSFCLGGCNPLASTSLTSCSPEPVCQNANHTFTDFSRILSNATYFDGNATKYDWVVNQGTILNSTAGELAMTLTQDNGGTRLSSTRYVHYGTITARLKTGRWGGVVTAFITMSDIKDEIDWEFPGNQTTEGQSNYFWQGVVPTPTDGKTHGNLTDTFSNFHDYTIDWQEDTLTWLIDGNAVRTLKRSDVTGSDGISRYPSTPSRIELSLWPAGINSSGQGTIEWAGGLINWDDPDYKAAGHFYALVESVTVSCADAKTNSANATSYVYGTNSSAFSPSVAVSNESTVTNAAVGALAASKAVWGALVGGGALALGAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ53</accession>
    <name>A0A2G8RQ53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ53"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ53"/>
    <dbReference type="OrthoDB" id="3266957at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="15"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="172" mass="18896" checksum="440E6300445EA824" modified="2018-01-31" version="1">MLAVPQPVFKIADELSTAQAALAAAEAQIATAEAAHDLLQQQLDEAAAAAQAPLGPGDQLNGPQIPRPTGPSWSIRELMQVTPSEYAEIQRTVRSLVIRASLDWTDNFRCQDPDKLATLFRAACAAHPILQCYTNNWATAAIAHQYMQNKRKHAYKQGYISKRRAHHVGDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ68</accession>
    <name>A0A2G8RQ68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ68"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="189" mass="21884" checksum="08C3A250442B63C0" modified="2018-01-31" version="1">MLGGDLSEAELEHEVLLLEDVLCRRDNVAATWIPAHAPNRYHDIFLLNVDPEPWCSIQRDHSIYSLLQYTLGCIYDSRAHPDRGRMHLRRIPLTDNIIDMHRLAEDLDNHPDAPTNNSGLLCAQLFHGWWIIRDCDGNYHQLPEDSYDFRALILPLHPGQDNDRLETLWRLHSGYLGVWLPQGCGIQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQV6</accession>
    <name>A0A2G8RQV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQV6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQV6"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013607401" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="159"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="343"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="687"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="876" mass="96720" checksum="1D43C48577F9F893" modified="2018-01-31" version="1">MLLLHTVLAVVCGGILVSARPEPVRGRDWYGEDTEFTDANVPSYHVQHSDPADSDELWEWAPQGPQHVLGTPPHHADGFPFPGADRKNWPELPHPFSGPPQKDGPEPPQFSPEPHYPPPPPGPPGPPGPPPPPPPPPKDGPPHFPHPPHFPKPGGDTKEQTVYQFLEGHPKFSRLFKLVNYTEDITNLLNDSAQSITFFALPDFGFPKPPHRPDSDEDFEFEDPFQMREGSVGDMLATAEGYLNSVRKPDEGMIKAFLKYVLLYNILPENTPLQELGKNNSFATALKLPDGSLDGEPLRVRLQTNLGLDPRPSVNFISKVLVPDIPVKNGLIHVVNKPVLPPPSIFQIGFLLQNAFSTFTSALQRVGLTDELDFRNVEDGSVQGEPAVSVFAPTNKAFAKLPPKLQLFLFSPFGEKALKKLLQFHIVPKAVVHSNYFHNASRSEFALPRDNSETGEFFGNIDYHLEEWAAISEERFDDEDSLQSNAWREKNCGSGGPPSWENNYQHGYGVPPPFPPPPPGGPFPHEGPNEGPHFPYPGDVPQHHGWPSTPASFPSPPEVWLHYPPPPPPPHYAQNGPGHPPPPPPLPRRRLMFGFIILRLPCLPKVLITRPTPRHLLPLLRRSGTGPTTLRPRTALTTLLPSHLLRLPTALTMRLTSRPRRHLKIGLTTLLHHRHLLTMALCSRPAPAALPRSSSRSPVPTSSSSSPSLPRPSPCSSVPPPPPPFENWPHHPPPGSPGGPHSPPPPPGKLPKGSPNHRPEVVYSVNTTMPTLLENFPLHLKVVQVAFKGPLPKKPSFASYHTIVVAHGQPVAVPDIAARNGAVHVITKLLNPFKKPGNHVEHEVEDEEPTFGPFAEEEDDWAGWEEWLPRWAEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQY0</accession>
    <name>A0A2G8RQY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_13663</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQY0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQY0"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="9">
        <location>
            <begin position="269"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="8">
        <location>
            <begin position="655"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="526"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL23912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="840" mass="92943" checksum="785F5C9CD5A578DB" modified="2018-01-31" version="1">MIIKGFKKRAAQPVRRPSKKRKVSDEDKPAKTKSKGKEKAFDRTTIPIPNQTNEDDLDLSADDMGMLEEYGSAVSFLRSLDEKGIARSKKETERLHQLHKPIRKPVEDDLPSINSGSEVEDEDEWSSGISDAESPLRSEDEHDVVSIVESSSAGTQRKRRRKPVQSDEEELTFETQPRKRRPGWDSDSESEKGVERLPIKLTDGRIQKSGSKVVLDESGLDTDEESADETIESAPAPRFEDVSTGARFGRAAVADVIGLKSRKARIQSAKEQIAGICQEILGDPENSLGLLRRLHTFSLPQLSTPTHPKPVSNDVVIRKLAFLSQLAVFKDVIPGYRIRALTDKEKAEKVSQMVQRTRDWEQGLVGVYQAYLRNLEGELKAKSDLAETALHCMCTLLVEVTHFNFRVNLMSCIVTTLSRKSWDKTSDLCLDTVISVFRTDNTGEPSLEIVRLLNRMIKERKYNVHPEVLSCLLHLRLKSELGIRASETKVDKENAAADGKKFSNGRAAARRAKGKAVDQPHLSKKAKKALKERKEIEHEMHEAAAEVDKEERATRHTETLKLLFVLYFSVLKNPRPTPLLPAALRGIARFAHLVNIDFFKDLLQVLKTLMTRDQEDLIVNTNTAGTKVPSGPSPAHPPAPAPNDTSNIATVQHQLLCVVTAFELLSGQGEALDIDLNDIVNRLYAILPSLALHPDIEIAPAPVRPQPHSAPQHSPADTLFRALELAFAARSASAAPPSWRAAAFAKRLLSAALHWPPATAARAVGFVAGLVERDPKLEALLSTEDRAGNGVYRPDVDDPQVCNAFGFGSAFWELHTLAASHWAEQVRVAAARLLDAHSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQY8</accession>
    <name>A0A2G8RQY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13675</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQY8"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="279"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL23924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="309" mass="33853" checksum="6F85E7C04DE48A2F" modified="2018-01-31" version="1">MSTTVTFFPAATSVIPGPFGGSLDQNPPTADRHITNGGTDWAWTVFAVMFVSDFVAIAWTFIRPRGTRLFHQIAVIVLTTATIAYFSMGSDLGATPIPPEFNRDGNTTRQIWYVRYIQYFITFPLLLLELLLATGVSFSDIFTTLFMGWVVVVTGLVGALVRSSYKWGYFAFGILALFYVWYSLLINAPRSTFAVGGTMRGRYWAGAAYFSFLLFLYPIAWAICEGSNNISPTGEFIWYGILDILAGPVFLFLFLASLRAVDYTGFGLMSTKYSETMPHEGGPAMRDTSGPASGGPEPVLEPAAASQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR92</accession>
    <name>A0A2G8RR92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR92"/>
    <dbReference type="OrthoDB" id="2637024at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="98" mass="10790" checksum="39B6F4F629283A69" modified="2018-01-31" version="1">MTTVDNRYQEGVVGEEPAPHARSTARREETHDDTSTYEEHSLAVGVEADGCEAPSEEERFKLGRSKLAGALTELLEALRSRYLTVQAVRAFLAPGQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRZ1</accession>
    <name>A0A2G8RRZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRZ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRZ1"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="76999" checksum="ED630A97AB79AB70" modified="2018-01-31" version="1">MASSSPAGSAKSLSESRAEALQALLDSLAPGAETGGDGKLNPGQVRRISDRLGELLGEDAIPDSAQRNEKGELVNEEGLPIIDIVEPVPANETSVAANAVPASQDPNLIPLWALSIQEKARRRAERDRILDLLEEEERIQQEKDEVEERKRFKADLEKRKQTAEAEMDALKKAREMQKKMGKALLKNIVVAREREEQERRAEEEAEKQAREERKKLKPKKSVTFADLPPDHEHQPANSVPMPPPFDWGDVSPATLQTPTKDSLITKNQMNGGPMRMNVVERKPGQKGGPKSPPPPRQRDSDDESEPDSAVTVDFDEGDVVQADHSDAEEPPSSSHGESDESDYGVPQDDEPVVWDVEGYDYAQHQREVALAYYEKRATIGADARAAMRNHDHPEGENEWDQPDVPLEATLAGAPPKPSVSRFKSSLSSVSSLPSQSLGGSVLPASQSSGLKAAVRLGKLENGNLIGGEQGESDEDIEPAAKEMLEMLKKGEVVNVGPSLPPDVLVTDSDPAAQASAGPSTPSTKPSRVSQFKNSLTVSSTPTSSAPSSPGSSLSTPLTTIERSSPKLSPSGGTPVPVPIPTNSSQFASPWSQKFAEKRPVQMPGMVVDSPSFPAPGIVRSSSFPGPTDGPAFQSVIIDSPSFHSPASTLVGTPASAGPLSSSTPNLPSPSTPTITIPLSASVLERRPVVASEVRGSVPAGSRSGGATPAKERKVSRFRAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSN7</accession>
    <name>A0A2G8RSN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RSN7"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="1331"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="436"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="664"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="756"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="834"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1121"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1246"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="868"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1068"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1570" mass="170553" checksum="7B6B664A6720E52B" modified="2018-01-31" version="1">MHTVNIRRPDSVLGSEDSDQPDFRLVVDSPTRPKSRRFSSLSRSPRTTSLLLALGDVIQREDEEEEDWDEGESGELESSSGEGSEEHTNEDSAYAEAAADPRRPRSNEFTLPSLHSDAASDASARPTPILGLSDEARRLLHCIPSPPRHPSPHLPEASITDGSATLVDGISIRSGSPIRDSSALDEEAAVTPLRRPLTAQDPAPSNRESISSDLQDSPEGSAIVSDYPPSRRGSEIPDLFATPSRRESEAPVFSPSSRRTYTTPDPRSPAPSATSVAPESVPLPPSRSPSPSVSSPASEVPDIQPPTCSPSTAPLRLPPSPRRIANSHGSISSRDSMSSVLLSPIDLTGARRISYTSVAGSFEHSFDSGYAEAEPPRTPTRRLSTLSILSSPFGSPSSRARGAVGVSGVRDDGVPTASALFSPRFGAFPNALARDAAQELEEARHSRGGSVDSQLFTHEEEDDEDEDADRDAGDGDDLTGAQSQFDDAAAEVEIQVQRQSMTSDSFRDVPGGLEDSSLFSAVHASDYLAVDEDLLRASEASFGSDDSMTSLYDQYYTPTVHSSRVVSDLDAEEDQDASPTMVLGSFAQDLDVAHESSPIGLAYTQAEEDMLADEHDDPEDVSPYGLDYLETEEASPGIITSLCESSPRTVVAPQEPLPQVFVPLREQSPQPLAASPDQPLVEEQEQSPEMIIAHQDQLPDTFVAFQEQSPEVFMAFQDQLLVWDEREADLEPSSPVEASEEPSFVASDFYDEVSYVEPEEPEEDLTFPSDDFQHAGPSSIPIRSPSIGSSVSEVPRVFSPIQTRPPSSASSVQVPNFSLPSSARNSIVFAPPDRAASPAVSVPDDNAAESTSRPPSSLSQHSGGLRRLSLQSAASVQSSHSSQSGSKKVPFGFRNSVSSSDRSQPRRSDSLRHKPPPLLSVDNAEEDSHSRSATPLSPVEEIPLTVSPPPSSSNPRRLKPLRLSMILSSSSSSLGSALPASSIPSLTTATTATTAFTPSSPTVLSETSIPNTRPLSLSHSSIIPSRTYNTTGSSQPNSPLHVDPVIASSHSQPASAPITRPPSWSNRFSRKSNLQRHSRHFSSFVEEQQQQHHARSESRFSEPIDFFDERQEDEYNGYEAADQADETVRRPVSANPSHPRNSSIFAAQQSAQQKRLSAVSVRQSHRESLLVEPVHAIATPRPTLLFALASDDVEEVRRVLESGEAGVNDDVGPQSALAFTLSNPQLKNKTQMVKLLLAYGADTSVLHDPEEEEREERSSRPGSSRLSKLLEDVDPATRYYIERADSPQTRRASALIHRSYFRPLTRVRYDLIGQDRVLEQLFRVLSMPSMAPIVVLLCGPSGHGKSLLARKFGSLLEVPTHTVNMTTLQNTGDIWKSHSIAPYGEPSNHSLKEFLIENEGKRCVVVLDEIEKTQDEKILSSLLMPWEYGRCSFEAGYRHVDVSKVIWLGTSNIGHDLVFEHQDKRPTPETQLSREEYIDLMALLRPRASHRLGPSLLSRVTAVLPFVAFTADEKMALAAEALHGLVGESVTDMPPATRDLIVRTSLNSYIPSEGARSLYRAVSTLLLDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTP4</accession>
    <name>A0A2G8RTP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTP4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTP4"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20571" checksum="53CBF591C24D0552" modified="2018-01-31" version="1">MPHPDLVCVSSDGMEILVHKACIGSAPPVLRERITKASNITEAGHPILSFTEQSGLLADVLGLCYPGKSLLNLPMDPSKLAGIVIALDRYKIGGIRPAVFRIWNMVAKAHPIIRAYLAASRGHLQDCAEVAAEYALQHPIEGRYVADMEFSPALAYHHLLVYHWHASCGMRHDCETGASQRPPGSNLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU04</accession>
    <name>A0A2G8RU04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU04"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU04"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="3">
        <location>
            <begin position="96"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="314" mass="34954" checksum="23A1E909E51E94FA" modified="2018-01-31" version="1">MAMRRSLDALSVLSTDDLADYDVISDGPRSLESSIADLGAPPRFAGGEPAPLPSAREKFDTVALTAEEIQAYVQRSLNASLAGGRRDDSRTWRVYVDGVFGPLSPRDVLQLRQAKLSFPSVHLLVGVFSDELCDEHSAPTALAHEDRCEVLRHCRWVDEVVPDVPWTLHERFLRARQIDFVAIDEGTSIDPDCDRDRLKGYDLVKGLRKSIPTRRTNMSTPMPRHHNPFRQTPPSQVAEGTREQEGNEKERERDGLPPSARGTIKGPPIGLKEESELRAGLNEALENPFEEPKDTDTTPFEEPRVDEFGTGHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUJ5</accession>
    <name>A0A2G8RUJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUJ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUJ5"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000009">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MsrB" evidence="6">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="132" mass="14560" checksum="7B66E5AB1CCAA359" modified="2018-01-31" version="1">MDDSSKAKSDAEWRAILSPEQFRILRQKGTEAAGTGKYDKFYEEGVYTCAGCGTPLYKSTTKFNSGCGWPAFFDGAVNRHEDRSFGMTRTEITCAACGGHLGHVFKGEGFPNPTDERHCVNSISLNFSDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUY0</accession>
    <name>A0A2G8RUY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUY0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUY0"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="86"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL25322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="198" mass="21536" checksum="3CDBF166D1EE9148" modified="2018-01-31" version="1">MSADAGASSSKKPSLPPGMVLGPDGKPCKICTAFRHWKPPKQAPSPNANAASSPQQKTAAMMAAFASGTGFSQQQEPDEPVRPANCPPDVEELGRATWTFLHTTAAYFPEKPTQAQRVNMLSLLRALPVLYPCSSCAQHLGENMKTRPPDVSGRAGLSRWLCEQHNEVNERLGKERFECTVEKLDERWKDGPSDGSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV04</accession>
    <name>A0A2G8RV04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-carboxymuconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV04"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV04"/>
    <dbReference type="OrthoDB" id="10006285at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013580538" description="3-carboxymuconate cyclase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="42936" checksum="E8FB897226E37485" modified="2018-01-31" version="1">MKFSTSTAFFAYVCSAATLVTASPTGQPYVRMLTKASARYPDGAAYFITNDPDENMVVTASIGSDGTLRLDRAVGAGGRGLHGQTANGNTGPDGLFSQGSVQVFAKNRLLATVNAGSNTVSLFTIDPRKPTNITPLGDPISSEGEFPQSVAFNSDGSHLCVLNGGAVNGVNCFSVDTNRGLISLPNTLRNLGFNQTTPANGPPGTFSQITFSEDNSKLIVSYKGATGSGFLLTWDVQPGSGALSQDYTKVSVDGAMLPFSLTPIPGQNAFLLTDPGRGFEVVDFSGKQRGSAVSVSGNGATCWGTRSAKTGNYYTVDVGANAIREVQLDGSLKASVVATYTVANGTGPIDPETATIRNKDYLYVLGAGAGVVDVFSLEGPSKAKQIATVDVIGTARAAGLSLAAGNLQGMATYVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV68</accession>
    <name>A0A2G8RV68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV68"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV68"/>
    <dbReference type="OrthoDB" id="2745898at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45297" checksum="EA999ED0DA6D37BD" modified="2018-01-31" version="1">MSLPIPLELVEYAIDSLHDHIHALAACALASRAFLSRARFHIWREVTVPVEADPLHVRMETLLEIWDANPDIAPIVQSLTLKGVLSPQPRHRIQEYWDDPGGTMLLWEKLPNLRVLKFVQLNFSNGLHQLTPFAYSLPNLEELALADFNAVPQRGHPTSSPYRSSIVQLHTTPKLKRLSLTGGWVLWLFLEDLANLLLEPGMHAPLEALDLSCVVKSMNTRLLPHHLTKTLPSQAWAPVIASLAQTLRHCTLGLLAEECYPANLAKLYDSLKQCTLLQSLGLVCDMPHSTDIAGYRPFLILDTLADLPWPFPHLEALSLDLLQSRREPILEGCEEACTKLASAIEDRTRYPQLKRLGVHAKTTRNTVTVEGVLLADEQIDAQEKMFRSCFGRVEAVGVQVEVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX53</accession>
    <name>A0A2G8RX53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX53"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX53"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013815940" evidence="2">
        <location>
            <begin position="24"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="941" mass="104790" checksum="D4281FCFEE237030" modified="2018-01-31" version="1">MSSLRHHRIIIASLFLPNTTVLGDSAPSSPDESAVHSLAPSTPALLNSTTPARGSLLARPGGPLRSIVEDLRDKSRYVTPSITPRTEAANPFSRANGPESLLDALSSKLGASKASSGSSSSTPASNGGRNYQTTHNGSNAAQPRVQRRSSRSSHRAASRSLSASRHDPSHHSGIKWHYENNPHCNGGLKNAIDSVGDRLRRKLWVGTLGTNTDGFRESLRRNIEWRMREDRDSVPVWIPDSDFASCYDEFCHQVLWPCLHYAVPDAPKTKMFYESASFKQYVAVNQRFADAIVSAYNEGDIIWVNDYHLLLLPQMLRERLPNAAIGFFMHVAFPSSEIFRCLSVREPLLKGVLGADLIGFQTANYARHFRQTVSRILTAEALPKGIQLDDRFIDVGVFPMGIDVSSITAKKRDAEVAEWVKSLRQRYAGMKLIVGRDKLDVIQGVRHKISAFESFLDKYPEYQGKVVLIQVALQTTEENEAQGGVADVVSHLNSRFSTLTYQPVVFLHTQDLTFSQYLALLTVADAFMVTSLREGMALRAHEFVECQEQRHRPLILSEFTGSYSFSGFRSCIPINPWDKRSTAKAIHQALTMADDEASSRWEDLHNHVVTQSAQAFVTSFLVRCLRANIEHMQSVDSADIATLDVGRVLPRYRHSQKRLLLVDFEGTIWTRDMGTIARNAGATGTPEFEPPAEAIRLLNRLAEDPKNQVWLLSGLTKNMMDIVSEKAPKLGIVAENGCFIKPLPDRDGNAPWINVVANFNLTWKAACMEILQYFTERTPGSFVEEREASVVWRFWTEKNTQDHAADWHWAHRQAAEAQNHIFDSIGERYGLRIIPGSTSFLVLPNNISRSTAVGAILHPGGPARNQMTARAAWLSPDAAEADNATEFDYVLAVGKDEKLMRRLNELDNAETCSTSGKGTDAKWKLGAEEVVPALWRFAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXW3</accession>
    <name>A0A2G8RXW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXW3"/>
    <dbReference type="OrthoDB" id="2757362at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="62596" checksum="C568738539D238A8" modified="2018-01-31" version="1">MIFQAWKDLCETKRHGIGAEWVRATWVCKTWREVAFQAATLWSAVLVSRPLADDPPLSIQLDRTRGVALDLSISGGRMSEAELEEVFSFVLSKRNAVKQLQITFEVEQLLTIKGFVQGVGAEIVTLSLSLNCIQDGSDYTGGWKFTPDLFPRLRHLALDKLTPTPSAPLLTLTRLDLVDVYDEDHSNLVHRFLACFPNLENLRVEWCFVDLGEDTGSEPPIVELPKLRYLSVKDTAFDIWAALSSLRLPSLSSFHVLAECDGDVDDDFILPGNITPSFPFIRHTRCLSLTVGQPTTHLSFRGSLGDTLEDGPDWSITMPDPTLEPPKSDPDLYPAFLSADLRLAKFYWLGYNARRIITHIPHLVDPSLTVELQLHFAHGLPVVRDWARFFGAMPRLRTLGIGGGTLATAILEAFRADPGLCAELQDVALCAITSPGATRMEKGIPSFFMKAVGSWLRKRADVGTRLQSLTVRTSSDGSGSQSGDRGALARPEAKGKARADSEPVGFAAKLRWDLERLGDLVGKVVVEDADCPACSMKHKLLADPPKLADSEELASDGGRGDHDDPYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYI8</accession>
    <name>A0A2G8RYI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYI8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="103" mass="10794" checksum="6E35C2F3D3A3EF0F" modified="2018-01-31" version="1">MGGVELPAPALLRADAALAEALHRSGAMDAFRVPRNFVPSRYRGLGRGLTHYTPRRRVYEGPEVCLEVGLWEAAEALALEQSAGSDPGAPSHVGGAAVTVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ70</accession>
    <name>A0A2G8RZ70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ70"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ70"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573929" description="Transporter" evidence="1">
        <location>
            <begin position="20"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29518" checksum="252B919F899CB85B" modified="2018-01-31" version="1">MLAAAPLLVLAGLSTGVLGTSYFLTDNIRGSQFLSAFTHQAIPDPTHGRVNYVSQATALERNLTYASGDTLILRADSTQVLDPFGPGRDSFRLQSNKVYNEHVAVWNIRHMPQGCGTTNGNDCYTNSSTFGCGVIAPRATSFGPSFNAIGGGWYAMERSGTYIKIWHWQRDDTNLPMDIRIGSPLIDTSNWGTPVADFPDTDCNMATYFSPQRMIINLTFCGDLAGHNYPSDGCSGICEGEYIIGDYVNQNPSAFEDAYFDIAWLKIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ73</accession>
    <name>A0A2G8RZ73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ73"/>
    <dbReference type="OrthoDB" id="2750039at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="41677" checksum="3123C87D80155C99" modified="2018-01-31" version="1">MSLGVLAAASELRPVAINDLALNTTLYYAADLSYVALDIGLSCALFGVLTLLVIVAAIFLFRKGLGYRPVKILLPSTLLLYGSTALYMASLASHVGSVNRLAAQAQAGLFSDAYTNADVDAFEADVLKQSWMMTIALGLNLIVGDSIVWWRVCAVWKNRVVYTVGPLLIVLIFGFGVKALSGVHACVDPCKQPQLLLQDGFFVNACAALSLALNLLATALIGYKAWVHRRLLRGHFGCGRRKSRVLKALALLVESGTVYCLLLIIVVVYEASAALFAAPDVRQNAFLRTVADYTYACFIPVIAIYPVLIIVIVALNWSPIDHGLTRTDGTHLAGEDGACAPTRVTLNRATMSTVVIADSIQMRCVQDGDSEAGMLGAAETKRRPEVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZE0</accession>
    <name>A0A2G8RZE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZE0"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL26889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="190" mass="21019" checksum="7F9B2D60ACC4A8AF" modified="2018-01-31" version="1">MSAHAMSAQDAPRSPTARNSWPRSASAPDVFFDIEIDGVHAGRIVFRLFDSVCPATARNFRELATGQNGYGYSNSYIHRVVPHFMIQGGDIVEGNGTTGRSIYGPTFADENFRLRHDRPGLLSMANRGPHTNSSQFFVTTVPAPWCDRRNVVFGEVVRGMDVIRKIESYASDHILYKPSVDILVARCGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZQ2</accession>
    <name>A0A2G8RZQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZQ2"/>
    <dbReference type="OrthoDB" id="2734101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708291" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="14981" checksum="FC59CFFA587D463D" modified="2018-01-31" version="1">MKFAIALVAFAASALAQHIEIGTPKNSAKVKAGSKITVEVNRPNSLSGSTEVGIAIGLWPCGGPKGTSKCASVDVSQVLGTVVYTGSYKPAYDSAQPSKPPHQSFEITVPSSFSKGEVSLGVAHLSLIGAGSEPVYEFTNTTLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZZ6</accession>
    <name>A0A2G8RZZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZZ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZZ6"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="149" mass="16960" checksum="9274A37D55F2968D" modified="2018-01-31" version="1">MVPRSVLAHRLRLSAAVPVPVPYARCARSLTTQQQHPPASTQNSNQNSRPEPRTTDVPPPPQTWLTKRVKENPTARAAFVKLITLMGYGSAKQYAGRRAFAMYANVCVPRSDEEGVFWREEYLLPRLADYDYGYGCEKGFLLFRKSPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0P6</accession>
    <name>A0A2G8S0P6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_10269</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0P6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0P6"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="358"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL27128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="667" mass="72555" checksum="18618D5DF95C8B24" modified="2018-01-31" version="1">MPVLAAATNTSTTATNGTTGAATAAAPAGAAAPFDNSALIYNIDIFLLCVVAFFFLLFLPRGAIRFVHKREWVDGHFLRSVYVEGPKPVVRRPSAKRQDVISPVSRAHMPERERWAPEPSYTEDYMDKWGATTDASHTFLSSHADILRKASTASGHERRRQNVPTHMSGWSTIFAGPAAFLRRSIRPGLTIGKSIILLGYLGVVLYAGLYMSNPLAQPIRAGFVALSQVPVVVIFGTKNNLVGMLIGFGYERLNYIHRFAGRMFVLAANVHAIGYFYDWSADGSFSKKIALPEFTWALVALICADLLLLLSTEVVRSKFYNSIFVPSHVISVVLLLVALCEHVPVAVPYVLCAVGVYGFDRMLRLVKTRVAMARLRPLPDLGVTRVEVPAVNAGWRAGQHVRLRVLSWGMGWRGWMEAHPFTIASVSRSPSGEGLVLLVKKAGDWTNKLYELAQRAEYGEANGLGANVQVVVEGPYGGPGHAIFSSFSGAMFVAGGSGITFALAAVQDLMQKDAEYRSRVRAMELVWCVQDPAQLTPLVPLFSSLLAQSYDGYADLRISVYYTRAPESDDALKMFRNLPPKLTLSPARPRLGKILSGVVDRSAALFSGGRERRRGSGGLTGVIVGVCGPAGLGEGVRKAVGEFDPKRRKSVGGIELHEEYVARSDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0S6</accession>
    <name>A0A2G8S0S6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0S6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0S6"/>
    <dbReference type="OrthoDB" id="10071171at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01830">
        <property type="entry name" value="XynE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053140">
        <property type="entry name" value="GDSL_Rv0518-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784:SF3">
        <property type="entry name" value="GDSL FAMILY LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43784">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013600720" evidence="1">
        <location>
            <begin position="21"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="439" mass="46266" checksum="DDF88C5A851962E1" modified="2018-01-31" version="1">MKLPFVAVGIVSLFATNVRAQQTASSHPAGHWVAAWTSMPQLTEPANLPNPPFNTTGLVFANSTIRSTIHVTTPSSRIRLRISNAFGATDLPITNVTIARPLNGTAGSSAIDTSTLQTLTFSGSPSFTIPNGALVVSDPIDFEVKAQTELSVSVFLESGQVGNSITSHPGSRTTSWMTFGNQVSAANITGPSVQSVAHWYFISTLDAWVPKSISTVAFVGDSITDGRGSDDNMNNRWPDLLLARLQASRDPALTSLAFANQAAGGNRILADGLGPNAIGRFDRDVLAQPGVKFAFVFEGVNDIGVADATDAAQEAIGDAVIAAYKQFALRAHAAGLPIFAATITPFSAPGFNTTVQPYSSAVREATRQRVNAFIRAGGWFDAFADFDAVVRDPAAPSQLSAQFNSGDFLHPNVAGYTAVAEAFPAEIFKQFAEGVDGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S111</accession>
    <name>A0A2G8S111_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 12">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_10609</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 12"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S111"/>
    <dbReference type="STRING" id="1077348.A0A2G8S111"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000044">
        <property type="entry name" value="Mannose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="340"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL27460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="46175" checksum="72011B17DCED6911" modified="2018-01-31" version="1">MTTVFKIIPTTQKYDWGKIGSFSKVAQYAAASKLPGFTLDDNAPYAELWMGTHHTSPSRLLDSPSQEKLSNYLAAHPSLIGARVVEGFKDDGAAEGNLPFLFKVLAIEKALSIQTHPDKETARKLHAERPNVYKDANHKPEMALALTPFQAMCGFLPLARIADYLVDTPEFAALVPQAIQERFLSVASTEDSTDPKVKKALKEVFSAVMTAEASLFQPELEKLIARFKSGGAKPSEKDVRDLVVRLDSQFPGDIGVFCAFLLNHLSMNPGEAIFLAAGEPHAYVSGDIVECMATSDNVIRAGLTPKLRDVPNLVAGLTYNSAHASEHLVAPRPFQSSSHSTLYDPPIPEFSVLRAVVPAGGAESHRPIDGPSIAIVTGGRGTVEWGCREELDISEGDVLFIGAGEGVELRSASGGDDLVVHRAFVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S190</accession>
    <name>A0A2G8S190_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S190"/>
    <dbReference type="STRING" id="1077348.A0A2G8S190"/>
    <dbReference type="OrthoDB" id="2753034at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013985565" description="Hydrophobin" evidence="6">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="110" mass="10768" checksum="0804EECB6184A828" modified="2018-01-31" version="1">MFSRAVAFTTLALPLLAVATPVELAARQSCSTGSQQCCNSTVAANSASANLILGLLGIVLGDLTGLIGLDCSPISVIGVGTGNACSAQAVCCTNNNVGGLISVGCVPITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1I6</accession>
    <name>A0A2G8S1I6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1I6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="164" mass="17474" checksum="C1CEA3BB79BDC17A" modified="2018-01-31" version="1">MRIKNLVQLESDAAVDRPHVGVDVPARLEGGEARPADVGIAARARHVVAARHTLDGDLAARAVLDVVPHLPRLEQLLVLGVPVLARPALVVLHVAVAANPHEARWTLQNRASCGFAVDLGAVGRRAVVELVRARVDVGKEGRVHDGVELVRGKELLRDGKGDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S263</accession>
    <name>A0A2G8S263_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_11014</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S263"/>
    <dbReference type="STRING" id="1077348.A0A2G8S263"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="175"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="490"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="554"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="638"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL27860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="658" mass="73495" checksum="2343F7C1387142EC" modified="2018-01-31" version="1">MSGTPSQIQKAINQIQDKGPLPDIDFTQHQLENGYTISTQERVVKEVQAPAMSIPTDAQFFSKTDPSKPDVAFLKNHFYREGRISEEHALYILEKGTEILRAEPNLLYVDAPVTVCGDIHGQYYDLMKLFEIGGNPETTRYLFLGDYVDRGYFSIECVLYLWSLKIWYPETLFLLRGNHECRHLTDYFTFKLECKRKYSERIYDACMQSFCALPLAAIMNKQFFCIHGGLSPELNTLDDIRNIDRFREPPTQGLMCDILWSDPVEDFGQEKTSDSFVHNHVRGCSYFFTYQAACQFLERNKLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTLFSAPNYLDVYNNKAAILKYESNVLNIRQFNATPHPYWLPNFMDAFTWSLPFVGEKITDMLLAMLNCCTKEELEESSDEETLISPTPSEDASERRKVIKNKILAVGRMSRVFALLREESEKVSELKSVSGSARLPYGTLALGAEGIKEAISGFEDARKSDIENERLPPDLYDPESEEGKGLITSQPATPAEDSAAPPVSPNGVAAALEQVIATAPAPPTAINTSLGHVPSPGSPISPVSPLSSTASPFRRGHGRQASLGTTMTSPSTRRRSLESTMSLIQEAWDGKTPLQDPELVKLADSIAEKSTGNKDKDKTDSGRATPAATPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S294</accession>
    <name>A0A2G8S294_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S294"/>
    <dbReference type="OrthoDB" id="10543954at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="572" mass="62588" checksum="5E6DEA9A435C61F1" modified="2018-01-31" version="1">MATAIIDPQPRLPLDVQLLLAENCPDVPTLLSLISSHKTLREHGARLALQLPTARVALHTEPALYSFFHFLAPPSNPIANPPSGSRLAHLHTLDISLAIVRGTSIEGITVMLAHVPALSSLTLRDPEPTLADHAALYAALQRLTTLKALHAFAAGPATRRLFVEIASPLEDVTLAHDASVLDADTSLEIETVLLPHRATLTRVRATRATPFANEDDAAAGAGVEPVVFENVRELAIDEFAWDAVPGFLIAFPNVVTLDVGTNVGARWRLSPLMQHIREGNKWATGGLEAGDSDDSDTEDSGGEEEDGDGGDGDEEMAEREEVHELLEMAVDDQMGEQDGARAHSQAGENDERHVHDEDDDEDEAFAGEWLERVRGGLLDLYVFGNSCVVDNLIIDGQIEWDWACVPAVVADHRPRVLHMSVSSSMEVNTWSWKKLASVRDLCLKIVVEGVYDEQRLMVSAIPSPVYFQPHTLTLSSTFSQDTIERMVTAFAFCSTFCFNFVEKTEGSCPPLKSFDHKGFANRVFQASKTPTTLKLFVYTPSRVTTWCAAKPRVVDEDGSMELALVLSQEAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2C5</accession>
    <name>A0A2G8S2C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09951</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2C5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2C5"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="164"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="397" mass="42580" checksum="D12EFA1F41AB5088" modified="2018-01-31" version="1">MAAFIGPVNAWGTWQAYYQDNLLQDRSSSDIAWIGSVQSALGYGPGLIVGRVFDMGYFRLPTFISSVLFVACIFLTAECTQYWQFLLCQGFGIGITSGVFFNIGSMVLTHWFKKRLGLALAIAYGGTSVFGCVVPIFMRALLQHLSFQWAMRVLGFIILGLLVITNLTAAGRLPGTQDLGPLFNLSEFKKPAYTVYVLSLIINNLALNNALAYITVSAIDEGFDANFSYDLLAIVNAVMTLGQLVGGLLADHYDPLDVLIGSTFLAAVVNFAWPFATNVASLVVITVLIGLSIGGVYASMVQPFERMGRLADVGMRMGMGFTLITGGLVAGSPISGAIFDATGSYENVGYYSGSILVLSAALMAATKYLMAKPAEARKETPDGRRSQGSDSELASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3J7</accession>
    <name>A0A2G8S3J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3J7"/>
    <dbReference type="OrthoDB" id="2317741at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013788956" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="43"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="14189" checksum="A62D6436990F1477" modified="2018-01-31" version="1">MFGKLAPLVAFFAFAAVQPALGASVTLASRSTSAIFNPPVTYPTAGTVWTVGQNLNVTWDLSNAPQNVTDTEGLILLRKSGVTTPLILQHNFSIFDGAVTIAVPLVVEGDDYSIILMGDSGNVSPDFTITGSGIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3Q8</accession>
    <name>A0A2G8S3Q8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_08444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3Q8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3Q8"/>
    <dbReference type="OrthoDB" id="2758353at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="293"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL28410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52147" checksum="FB5E5119CCC83299" modified="2018-01-31" version="1">MDMIVKLPDSHGYDSIWVVCDRLTRYAHFVPCNEAMDAPALAWLFFDRIFRHHGMPESIVSDRGTTFVSQFWNALTSLLRTELKFSTAHHPQTDGLTERTNQTLECYLRAYVSSQQDDWVDYLPLAEFAFNNHASLSTGKSPFFANLGYHPTFNPLITPTATVPAANDMAQRLSRLHVELQAQLRATQNTQSRYYNEHVKDAPKFKPGQLVWLLRRHIKSIRPSDKLDHRRLGPFPIHHPISDVAYKLQLPTYLSRLHPVFHVSLLEPYYDTTAPLPHSNPVPFPISEDSPAPAIHAILDCRKLGQRYEYLVHWRDLPQDEDSWVPITDIPSTANELLERFHRRHTRAPRPPTSLLLRPSNPEPHTSTPSAFSNANNSSAPPMSSVQVPPPALSTSSAPAKPSSSEAVPTAPPAMPSVPHAAPRTPSPKPRRVDPRVWYEPPAETTTRSKRVVHPPDRLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3Y6</accession>
    <name>A0A2G8S3Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3Y6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="76" mass="8312" checksum="22F420A4907E3CA8" modified="2018-01-31" version="1">MRLDVVRSGRHRDVFTWAIRHIPAFASNLDPPRSLCISRFDGCTDTATERPAQRLSSNGASGRRGTTALDGDGIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4T8</accession>
    <name>A0A2G8S4T8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4T8"/>
    <dbReference type="OrthoDB" id="3352270at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="64" mass="7019" checksum="41383A2C62AF881F" modified="2018-01-31" version="1">MQTLLAVKEEPSTPKIIGSDISLEVHVRELHLKVAKLDCKLSARHVLGTCGSGPALRAIQHWHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4U4</accession>
    <name>A0A2G8S4U4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4U4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4U4"/>
    <dbReference type="OrthoDB" id="2800603at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="71107" checksum="D8DCA4C18618230A" modified="2018-01-31" version="1">MQHAQAVPSELALPPEALHRICEILIATKTPAVNRRSYGQPNCYYVGLQTVLSLARTSRALHEHAADTLWNTIPSFGVLVYTLPRDIWSYETLGLGDEEDPEAGPLDIELNLKRPLVKADFARYIHYAPRVKRILHPAECTQFPPRTRSLLFSHNILDIFESYPHGGVLPNLRVLRSSPPLPYCQHFYRSFPSLFGPNVQEVFTRSPRVNPTAPRVDERDYRWMLTELYFIAPNLHNLVLNVEGQAESLAQANTPILSNIAVNTSQCLRAFLVGNMAINLYALRHLAELPCLMALAIKLDDAITAADLAFLREAGGETRFPLLQKVHLVHSSNLSILSLFVQAIHPTLTPLKVIDLTVDASIPFQDITDFLTTVADRDGARAIQSISLNCWVSPQSPGPHVLTEDHLRPFFALGELTCFDLDVKCEFDITNATLARIAAAWPNLTVLGLGPAHEIKTSKVTLDGLIPLARGCPRLKRLGLTIDAETPLEAPVDLSGPYGSLLLYGPTANVDLSMLPDPEVATPGSFEQKPLHESPLEELRLGRSAVNIDDPVVVAGFLFRLFPRLKKIHGQWRPLDILDPEIVGVELDLPAQEIREITAESEHRTVWHWVAAVALPEFRNVLKSERKASQGARAGEASLGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Z3</accession>
    <name>A0A2G8S4Z3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Z3"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="16787" checksum="B4331D76B926AE37" modified="2018-01-31" version="1">MGLPASRFRSFAFLTSDDPASLQADMAHQHGTRLFIDGLPGSAILESMCKVDAHFRREVDMTGVPNRKMGRGSGSDSATVEIVALKGYYIVSMSLLMLQGALKRTNTWAAFPATKKTANKKNIPTNSAVTAPNTANTKTGRAKLHGLDVIDIDYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S516</accession>
    <name>A0A2G8S516_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S516"/>
    <dbReference type="STRING" id="1077348.A0A2G8S516"/>
    <dbReference type="OrthoDB" id="2748260at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="767"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL28879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="890" mass="100855" checksum="B8270465AFAD1F87" modified="2018-01-31" version="1">MASGKSSAAKAKKPGSTSKPTGGKKKPAKTEKTAGQRCPRRTQKKRKAVVLSDSESEADEDDEPLEDKPPPKKKQKATSRHTKNKLERDGLEIVEDGPGSADDEEDVQDEGRGEEDAPKDDVDSEKELERARGRWRSPIYAFFEEDVVVDYKDDRKSHLFTCAAKGCGIRVRRFLDTKDAASSGNLFKHARGCWGDEAVDRAIKFGDANVVREKLVKPKKESKSITEFFNQKAIMDRSESLVLTQSGVLHRVWAVRWVAEDLHPFKMVADRGFLMIAKSGRPGYYVPSPTMVSRDVKVVFIATRKRLAKMLQGYSGKLSFASDAWTSPNHRSFIAVTVHLEVKGRPLRMLLDLVELAKSHTGVNLAVAFRDVLHEFGIESKVLSITLDNASNNNKMVDHLARILAAFEGEYHHTRCFAHVTQLVARGFVGQFEVKGVKGEDVDGLVDDDVHALLKLAENMDEEEREAKRIREREHGGDKELEEGWDDSVEEDDEEWVSEVASLTDEEREEYEKQIRPVKMALVKLRKFSFKIVNSSTKLLPAWRTVTADLKLPNRLLPRDVRTRWNSTYDMLVESLIFRPAIDKMSDPEEEYGLGAYRLKKKEWTLLEQLADVLKVFKHATEFFSRETPSLATVIPAMDYIDTTLTNQARDETLDKAIQTAVGMAKKILSKYYKLTDLSATYRIAMILHPEYKLRYFEEAGWSRGWIQNAREMLEEQYDFQYKPEEGDEDSQQSDEDIKAIPEGANIFDHLPSVKSTRKLASAAASEIERYLSTGTVKVNNPLKWWTDNAALYPNLSHMALDYLSIPATAVDVERVFSKGRLCLSHIRNRLSAQTTRALLCVGEWSRLDLVHMDDIKAAAALPDLPEDEEESEDSVQEGWDRIHELLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5L8</accession>
    <name>A0A2G8S5L8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5L8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5L8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="793" mass="84692" checksum="D28147DC6256CF33" modified="2018-01-31" version="1">MCLKSTSSELRRFPTEGNTSHEALVDHYGNILNQTGRRPQQKPDYRKKTSINHRPLTAPPGFWDTSIESNDLKTSPWGVLAPSIKHCRQSLRASLLPFPVQGGGEHIDINNVSSGSDDEAENMQPQHPYNPGAPDAAAANVAVRRGPVGSVAEVQAELHTYQAQASQLEKENRQLRESLQFMQNEVNSERKNGESKVPSELKPLDRLIRKAAVLYATQCRPWVPTSAFDPPPSWDIDPLDFGQCFPSEPGRSLSALKHAYSAELYKLVDPALRPHLGNAWVQARFTVLVLHRKSNMVNNTKGHLSDIFRPLHDAHLVISDDLSDVEKDPRCKYWRGEPGDEHPPIMYALGQHGDLRYVFQSMAFVNFIKIALFGSGALHIQNGRYDGKSFGRKHKITTLDYHMIAFAVTVLRFFLSHDAHFEERGKQSQTPFAEFYDKTFKALLEYQNDEWLSKILEWLHLQVFGTPLARNSGGADVNAPPPDVLPETGRQIRWEDLRTLARPQTDSDDLEYASAPVACPAAPAAAPPPSAAPALSWASMQPTGESVSGVSAPPPIPTSTRPSLGHVQLEDHILSSHVPPPSLPLSQSPSRLPAPPGLRRAGTGHWAVTPRPAGASSAVPDDVGATNSGVASDRLITSLSEIMLTGLPSTNVLSNDGAPRGVVPHSGGAYYSGMPGGIILNGANAPGGGVVILNDENAPSGGVIHGGVNLNGNSTPGGGVILNSGGAPGNGFMPNSGGASDGRAPSDVAPSGGIVTGPGVAPNGIAPNGGGTPSGDTLNGSAWNHSSTIKVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5M4</accession>
    <name>A0A2G8S5M4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5M4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5M4"/>
    <dbReference type="OrthoDB" id="2446696at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="495" mass="56510" checksum="B07496F3175958F1" modified="2018-01-31" version="1">MFFGLANSPSTFSALMNDIFKDLIILGKVTIYLDDILIFTNDIEEHRTLVREVLKRLAERDLFCKPEKCEFEQPKVEYLGVLVSENRVEMDPVKVKGIAAWPVPQNTSDVRKFRGFANFYRRFIKDFSAVCKPLDRLTGNAPWKWEAEEQEAFDELKRRFTESPVLSMYDPDCKTRIEVDASGYATGAVLSQEGEDGKWHPVAFHSESMSDAERNYEIYDKEMLAIIRALQAWRHLMILKVSLARWALYLSQFEFVILHKPGTSNGRADALSRRPDHQTDDADDNLDRVLLQPDHFRVLAAKRGHMSVVPEKALLRRIRECGEREQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGRVYVPKDDALRAEIVRIHHDLPPAGHPGQAKTVELVTRNYWWPGMVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNALQLIADRHTLVSLFPFLDGLLPMSSLWSFVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5Q3</accession>
    <name>A0A2G8S5Q3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5Q3"/>
    <dbReference type="OrthoDB" id="3255996at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="426" mass="45520" checksum="BA438C7A3A309C3F" modified="2018-01-31" version="1">MAKGNSPAVQTQSKHSSTKSTNGKPLPKSKKSKKGTTSNNSHDEESDEDELEEDGSGGEKKGAKKLLLTPVTPDPMRRIWDNNLTWSLITCISQNPSMASGGSKPKSDFYLELARLLFEDHGRYGEAFAEAKGVPAKLAKWAGKIKNRMNTLEKKTHRYFELMGETGQGISSEADINMNTNNSIKAVFLYYFEMLELIGQCPNVIHAGVGNSLTKVDIGAIMGGSATNQSLTVDDISSTPPFPASTYPALQPSASPAPSPSVIELDDNSDSCRPSHKCSASILSGHSSTANEEEANLLAASILAESTLVDSKKLNTAVTSKSSKVGEEERQIGVGESGKKVGGSETGKKTGAKPGMSTPASKGKGASKKLKLGDQFAEVATAEEQTLQKKLKLCLSQTKLEKLKLEGKIAVKRDKIRLKADVTSWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8H7</accession>
    <name>A0A2G8S8H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07650</name>
        <name evidence="4" type="ORF">GSI_07784</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8H7"/>
    <dbReference type="OrthoDB" id="2751587at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="292" mass="32913" checksum="A0FD06594D2FE769" modified="2018-01-31" version="1">MLEGAAIKFSATINNYLSLQEETNDLAEVDETIQELSAFRNKLLLLSLDQTAEFGHLDTSLDKLGNDIHSGVLAHTHSLSNEVANAAGRIPSLERELEDKLNEKKRQRQCEELWVGAQDLWDSYGSHMFKPESRTGQFTAQLTHTGPAPQIMARVESPTRLLIGGWDFEEEYHIARIEVELRDMRAKLRQAESELQGHKNLDLDQVLDAIDEIRRNLGTQSELQEDIFSAVKTKLTNESKSYLKALQDSRVDLSPAGQHEYRNAKHRIMSSSKGWEQKAAVTSMPRSRSSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA78</accession>
    <name>A0A2G8SA78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA78"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013829483" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="419"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="534" mass="56603" checksum="9F4918040012DB19" modified="2018-01-31" version="1">MYCSPRLLAVAALALRLTRSSALNVSVPISSPSGSQTLARTLLSFSIEQDRWPDWSGIDSRNEFTYSALTTLATLTGEPPKIRVGADSEDHTFWSPTVTVNEDEFPPANTITPYPEATHITVGNAYYELSRFLPRGTHMTWGINLGADNVTNAVNMAKAIVRAFRTSTVKASGVVLDLLEVGNEADLYRNNGLRPSNWTVQDYVPDWISIAGPAVAAAGISGPDGPVSVQGAAFAGQGFTPTGIFNLGILDSAPGKAITQISQHRYSAAFCNGGDFPLTSFMSKQFVRGNLTVFNADIAETHSRGLTYVLGETNSIACHGAPGVSNTAGAALWTIDYTLQAATLGIKELFFHEGVGYKYDFFQPVTLNRSTIDGSPLDPPSAPHIQPSFYGALVVNSFVGTTGASTIVELDVGDADVSGYAVFEGTAVKRAVFVNLHAWLASSTGTRPSVHIDLDFASGPGASQSQVDAFWGRRASLRRLAIGHADDTAGLTWAGQSYENSANVAPTGGLVTETVQASEGFSISSTEAVLVEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAK1</accession>
    <name>A0A2G8SAK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAK1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAK1"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="21401" checksum="6E05231A06EC2EAC" modified="2018-01-31" version="1">MSASQKVQQHPAFIQAQDKANYYVNQLDKELSKYPALNAFEQRTQVPKSYAFLGAVLALAVLHSVNAFASPVSNLVGWALPAFLSVKAIETPGHQDDIQWLTYWVVFGFFNFIETIALRVVLYYVPWYFAFKSIFILWLQLPQFRGAQTLYGTVVRPVFVSIHGGASRVAPTQSEPTVTADGLRERVAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAN5</accession>
    <name>A0A2G8SAN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAN5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="17355" checksum="E8BFCB55F5C94A19" modified="2018-01-31" version="1">MSDEMTADWIKGDDEETDARDDNNAGIDNVRDEDDARDKDKATEADVIEDEVREEEEARKEDELREEDKMRALDDNNARENLEAGDEVKVRDGGEVRDDGNSEATDDRDAVADNEGSRGRTGDDIDDNNMRGSGPGLMRHGAWLRKVETWAAPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAQ1</accession>
    <name>A0A2G8SAQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06998</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAQ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAQ1"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="519" mass="56603" checksum="CF201EFEF013638F" modified="2018-01-31" version="1">MGNHSRKKQKISNEPLAHPLGVPARFGDQEEKDEEELLLESFLFGPSDELVSVSSYKSNFVQDTTPDVEDHGQALLGRKSSAWTDTDDHSLQVSLAADKRRRKLRDALIEDTVDGREYERRLRREFEKENPSPGWARDARTLPFAGGEGKRIRTSMGSDVEEEEDPARGGEGLDYLLSQAASILETPHVKSLPHGTVAIERLRDANLSAKAEGEVKVVQFHPSPQVPILLAGSSDRRLRIFNIDGHTNPHLHTLHIPTLPFTNALFHPSGTSVLLTGPRPFYYTYDLQTGTTQRSPRGLWGTTFASNIQGSQDGSMEVCAFDQSGSVLAVAGRRGHVHLVDWRAGGGQVVGSVKMNAAAKSLWWLGEELLTLGDDSEIYVWNVGQRKCVRRWKDDGGYGSHMLGGDRSGKYLAIGSKVGFVNVYGADATHGGGGGGDRPKALKTIGNLTTAITSLRFNHDSQLLAIASNVKKDSMRLIHLPSLTAFSNWPTSSTPLGHVTSVDFSAGSEYVAIGIIFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAV4</accession>
    <name>A0A2G8SAV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_07064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAV4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAV4"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000524">
        <property type="entry name" value="Cell division protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="3"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL30895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="367" mass="41355" checksum="4459D72FF5D23385" modified="2018-01-31" version="1">MNYVQLEKLGEGTYATVYKGRSRTTNEIVALKEIHLDAEEGTPSTAIREISLMKELKHVNIVRLYDVIHTETKLVLIFEYCERDLKKYMDVHGERGALDPVTVRSFMYQLLKGTAFCHENRVLHRDLKPQNLLINRKGELKLGDFGLARAFGVPVNTFSNEVVTLWYRAPDVLMGSRTYSTSIDVWSCGCIFAEMISGVPLFRGRDNQDQLLHIMRIIGTPDDRVLRKIATEGQTEGQAQKQYPRYPKIPFSQVLPKASPHALDLLERLLQFDPSKRISAAEALTHPYFSTSQPIYTQPTPFTPAVIAPAYQYQQGQGQAQGQFQYGQQEAARAAAAQAQLALAQPQIPGAGYGMQYPQQQYQTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBK8</accession>
    <name>A0A2G8SBK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2735574at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1673" mass="187763" checksum="598352F165F00AF1" modified="2018-01-31" version="1">MTTVYNPGADSHERSVDAHEEPHLNFDVLHLICNYLTDIPDVLSFALTCSALTEDALRRRLKMAPVDLSDAEMINSFHAFIFSNEPSRAPFIYGLRLKLPSPCGLQATGNSDFRIIANRLVAILKAAVHIQHLGFNTSICNSVFDAMVRLTTVRELHIFNDVLMYQGLLLNRLAIFQSPLRSLCIAGSEHVGTAVSASFLHDRLSHLAPTLEFLDLDDFPIDVLPSSVTTQFTAVRSLKLQAYFPPNCDLLGVLLQFFPNLDNTLDLGSLNAYMTQGDVPAFRERCEEAQRRHSWSGLDQLVCDADTAYLIALQCPIRRMSTRITWSVGWECLAGALRHNSPRQLRVAVHFDAGFRGLDNPFPPEAVDKLTHLVMSADIEVRYRCGAGRKANNRHWDRFIDRLVRSIQHLRLTHLRIIFRASVHHSARMPPRRDELFQTACGVDLRSAAARFVNAMPSLRYLFLTACGHTYVVPAPKARLLFERRTLDSWFSSAAWQLDVACDNATHKSDSGVSDASLSSSCVKLSRDAMERIMDREELRLSRYEESVPVDPSADDYPSHLLYTFVFVHGVVSHGASMTLRWLVLYPGSLCRLPFSRPLPQTADDCESCGGKHKLTETLEDTGLSRAVYSTKHEDLDLSNAEIINSFHAFIFSNEPSRAPCIYGLKIPSPYYDLEDIDRSCFRYVNGHLVDILEAAVHVKYLKFATSISTLVFNAVSRLTMVRELRILADAPQSPLRSRLPTFRSPLRSLHLVGSQLVADTISARFLHDRLSHLAPTLELLDLDCFPVDIFPSSVTTQFTAVRSLKVKTSFVSSDFHPLDVLLCLFPRLDNTLTLGPLSMSLRGDAFYPEFRERSKDAQKRHAWSGLDQLACDAETAYLITLQCPIRCMDIEVGWSGAAPYLVETLRHQSPGPQQLYVHLSLYDGFGALNGLFPPEAADRLTHLTVFADIGIPQGLRSCRRMGDNAPAPRFAMKMISSISHLRLTHLRIVFRFTVLYQSMRKASVHDADPADIRGAGGRIDLDRTAARFVDAMPSLQYVFLTTCGEARPILSRRSLPSSVPPKTPHKWGSSKAWRVAYDGENIRHDLEPTEVRRGACVELSVEAAERIAGEEGLELSRHEEDGFAMQSGAARLEHDKLEPRLNFDVLRLLCSYLSDVPDVLSFALTCSTLTELSFRRRLRMAPVNLRDAKSVDRFHAFIFSNQTSRAPSIYGLRLPGQRVYNSSVVDKCRLDKHILALLKAAVHIQYLDVPIPTRVLLLDAMVNLTTVRELKVDSNDSQAPLCIRITASRSPLRSLCIRGGSHFVNDAISASFLHNHLSHFAPTLEVLQLDYFPITLRPVKITTPFLAVRSLKLKNISGFSSECLAVLLRLFPKLDNELEIDLWNSRRAEEVDFPGIQEQNKKAQNTHGTWSGLDHLVCDPETALLLALRCPIRRMSTTITWPRSQRKYLAGALRHNSPRQLYVALQLITGFRGLDGLFPPEASGTLTRLVLCAHLGVHYRRGALKKANNVHWDRFIERLVRSIQHLRLTHLRIVFSSSVNYSSRTLPPDEELFQAAWGVDLLPAASRLVRAVPSLQYIFLTAYGHTYVVPPKARCSAFQQRTLDSWLSSGAWQVVHFKEASHPGGLSDASGSSECIELSREAAKWVADQEELQLSREEEVGDFSLSEIAKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBL9</accession>
    <name>A0A2G8SBL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBL9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBL9"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="28326" checksum="963E36DDABB84298" modified="2018-01-31" version="1">MSAVLAGPPTECCLRTVHHTGDAKGTVEEYAGVKTYVARPPSGDASKVILYFADLFGPMYINAQLTMDYWASNGYTVLGIDYFEGESVLHHLGKPGFDWREWMPPHQKRAPELLRPWIEDVRKRHEGSKFFCVGNCFGAPYVMEALAEDWMTAGAFAHPSFLNEAHFENIKRPLLMLCSEEDFSFTPENRRKAIDVLVEHKKDYTMLLFGGVAHGFATRADPSVPKQRWAKEQAARTVLDWFNHHAECSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC81</accession>
    <name>A0A2G8SC81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC81"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="153" mass="15746" checksum="E570CE9892663BD7" modified="2018-01-31" version="1">MDGMRAGRVAIRGEADSDGGLVDGEDAGVFSSGCDGNANTERGEEDSKLISVCAGEERRADDDVLPLRVRVNEGGAGFTAVKGRCRDSGNGDVELLPFVRAVRRDLTGCAGAEGGFGLRPFGGLNGDGERFGAGLVLLRTEGAVDTTLAGLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDB9</accession>
    <name>A0A2G8SDB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06456</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDB9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDB9"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PB1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="816" mass="87965" checksum="DC4E76DB3C8DE319" modified="2018-01-31" version="1">MSPIQFKLSKPPDGLVRRVTFPERPSWETLAIKIQSLYDIPLPSIGVSYVDNDGDEVTLSSEDELQDFYQSLLPGNDGALILVRLSVRDLDSLRSDKPLPDTPRTGSAMNYRNTFGRSAPVLFEMEVEDGWQPIPSGLGGVYVGGQPTAFVEVLDSDADITQFNNRDKDSSSTSSDSTNTLPEIIPTPTTHKGKGRARSISDCRSISPPDTISSTQSVVAAESGPKHPIHVVAMKSSSTGTFHRGGSRSRSVSALSPRIPTPKIRTPISAAEKSSGAAQDDDPPLPDLDDMDGSQPHIANDVANLFDTLSTILSSHPELSEGIRTIVRNASNGSYWQTHRDQVVRAAEEIRRSVVAGADEVRHAANDGRRTAEEAAGRRVADALAEVIRVIADITGAQPVDPNAQSSGHGFETSTPMRERHPTGSNPFDDPRMRPSGPPPPHRGGRGRMSWASFDSRWGGFPFGGPPPFPPFPPGPRPTGRPPPPGPPPPPGPPPPPGPPPPPGAYNHFGGRGYPDFTPDRNLPGPPPHFHGRFGRPPFGPHFHHQPGEWDNDDSFVGGPRGGHHFGGWNRHRYHDTNWGDTVPALPPQPNTSDEDVEVTMYGASPLESPDAAKKKLQAAKEVYVAEKEKYRRAREERKKRRMNVSTDSQTKDVYDSPVGPRAAQEPTAVAGPSVEEVPPVAPLPPQTVPAPQIISNARGPFPQLELYSVPRRSHTIHGTGHRRDASWGTFGSVTGMGSTQAGRAAAMDSIVHRLCEMGFTANEYPVLNSKVDAHIPLNGEVSKEREESIVTAIVNELLPASPGASQASGSGMRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDL4</accession>
    <name>A0A2G8SDL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDL4"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328">
        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="245" mass="27879" checksum="AB62ED7092E93942" modified="2018-01-31" version="1">MSKSSHFHPLEFNPTTGEPFLALPAPYENIIITPPRLSDAPAIILSMSDPAIYTFLEGPPFPYLPEHADQWLSRIKQETDAAIETLRRANEEKPDEPPIFLEQSPVRIIREVRDDGSDLFLGDIMFVRERYPDLDDKELKETVLQRNAARDLGDPEIVWCIGDFLASSHHGKGIMTAAIKTFIYEWAVPRMGVRQIRVETFSDNAGSRRVFEKLGFTYEKTVAIRKTLNSGRTIDGMDVLCWEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDM7</accession>
    <name>A0A2G8SDM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06566</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDM7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDM7"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="96"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="9">
        <location>
            <begin position="276"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="339" mass="36555" checksum="5012C02BDF2498D3" modified="2018-01-31" version="1">MSSPSPSQDQEEQQVHVSGPLLVDKLSEFGITVQDIKKLTEAGLHTVEAVAYTPKKNLMSIKGISEQKADKILTEALKIIPLGFQSATEVHARRSELVHITTGSKNLDALLGGGIETGAITELFGEFRTGKSQICHTLAVTCQLPVDMGGGEGKCLYIDTEGTFRPVRLLSVAERLGLNGEEVLDNVAYARAYNADHQQQLLTSASALMSESRFCLLIVDSATALYRTDFNGRGELSARQSHLGKFLRTLQRLADEFGIAVVITNQVMSNPDGAAGPYMANEKKPIGGNILAHASTTRVQLKKGRGANRQAKIYDSPCLPESESTFAILNSGIGDPEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDU2</accession>
    <name>A0A2G8SDU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDU2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDU2"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="511" mass="56702" checksum="92FDA874FE4AA82C" modified="2018-01-31" version="1">MCRFVIYKGTDPVQLSHLLTRPCHSIINQAFDSRLRLDRRRPINGDGFGVGWYDSVHDEELGSQPCIFTSVTPAWNNVNLLRLAEKIKSPLVFAHVRATTAGTLSLDNCHPWSYGKLMFMHNGGIADFHKIKRKLQMSVRDEVFDWLPDPMAKSFTPGVLQRTMLETIAHINALTEEYGITEPSLMNFCVSDGETVVATRYISSRTDEAASLWFSSGSTFSEYAEGGHYKMSKTDKRENLIMIASEPLTFEKADWMEIRTNHMVVITPKMNLLQIPIVDKFYVTPSDPAALNRGVEFAAAKGLLSPILIFLPLTLSTLSRSAFLLLSLLLFLHSLIHGTLVLLWGSPMLSIMQVPMHPFLLLVCFNAFSEGVHPWLTMAATWWGRILQWSSPGFIVMEGLSSLLVAQKLGQVGKELVGEGEVYQFGLLIAAAAAYVTSSFWIVVSYPATADSPLSSTLLGVALTTVIFLTFIGFALRRTNVIESSCLALIVAYNIWLCGVDDALVLDPGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEH7</accession>
    <name>A0A2G8SEH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEH7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEH7"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="161" mass="17692" checksum="E3A2A0BB4396F025" modified="2018-01-31" version="1">MFVGYVIDHPLSSFSFSMFDRRSMVWRRSCVLPLSCLNVGLLVFARIDVKDVRYVINYDFPNNCEDYIHRIGRTGRAGMKGTSYTYFTTDNAKQARELIGILREANAQVPPQLEEMSMFGGGGGGRSRYGGGGRGRGGGGGGGGRYGGHDNGYGGRNNDRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFH4</accession>
    <name>A0A2G8SFH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_05223</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFH4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFH4"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="524"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1177"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="260"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="750"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL32520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1203" mass="134786" checksum="81E7D2F480B01C58" modified="2018-01-31" version="1">MHIHELILDGFKSYPVRTQITGWDPSFNAITGLNGSGKSNILDAICFVLGLTNLSSMRAQNQQDLIYKRGQAGVTKASVTIVFDNSDRSTSPVGMEDYAQITVTRQIAIPNLSKYLVNGHKSTQQAIQTLFQSVQLNINNPNFLIMQGRITKVLNMKPAEILGMVEEAAGTRMFEEKKEKALRTIAKKDKKVDELKATIDEEITRKLDKLREDKRIYLAWQKTCTELEHIGRTLRAFEWTDATQRAEAKDEEIAGVKEAKQSLDQDKKKYGNELKAAERSMEEVNAQRDKELKKGGKFKQLEEQVSELGKTLAKVRTQVEIKESTIADEEGKIVGSEKELEELRVNLEEKRKQVDKLNAAHAQVKDKQTALQTSVNSSEELLQTLLTGLSSSNNNGNTGGGYMGKIADAQARLATGQAEEQSSRNQLDRCGKELKALEADWKKVERDASDAKRNLETMRANVDNFRRKLEETGWNAEQEQSHENDLRNAKNEVRRLSEHRDSVKRRMRNVDFEYEMPHPNFDRNKVKGLVASLVNLDKVNYRASTALEITAGGRLYNVVVESDEVGKQLLQNGRLKRRVTLIPLNRIESFRVSPAKIQAAERISGGKARLALSLVGFADEVANAMFYVFGGTFICEDAETAKQITFSREVGVKSVTLDGDVYDPSGTLSGGSAPSGSGVLVQVQELIEAEGNLTQARETLAKLEREAAGSQGAREQWRSLSRDLGLKEHELELLQKQVDASNASRIGGQVEQMKKTIADLQAAIQTAQEKQKEAKAEIKKLEKDMADFKNNKEGKIDELKKEVTKQKAELQKHNVLVKTQQREVQTASLEFDQLGSDITLAETQIEEARAAVEKLHHELDKLKGEVKTHEAAAAKAEQKLAEERATLSRYDEELKSLDRVIREKKASIADVDLEIGKRELEMAALAKEKASLEKIAADLEKQYDWIADESHLFGKAGTAYDFRKMNIGELRKKAAELESQQAGMEKKVKPKSVHTIDATEKQEIETKRKLQTVLKDRGKMVETIETLDQHKRDTVETVWNKVNGDFGAIFAELLPGNFAKLQPPDGQDLMQGLEVKVRLGQVWKQSLTELSGGQRSLIALSLIMSLLQFKPAPMYILDEIDAALDLSHTQHIGQLFRTRFKGSQFIVVSLKEGLFTNANVLFRTRFRDGTSIVERTANRSATAAQGRDQEDENVPPAGRRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFV9</accession>
    <name>A0A2G8SFV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFV9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFV9"/>
    <dbReference type="OrthoDB" id="2757415at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013567188" description="Hydrophobin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="34291" checksum="5B2D45B1F00AFE08" modified="2018-01-31" version="1">MLAFQLTLALAALLGQGIASPLITQPPTTVSSAALSAATIPIAQCLTSVVCCQSTVDLPTVPVDSLTSILPLPSGIPIPTLGPKAGFQCSSATDLDILGNQCLAGGTPLCCQFVAPAGVVAEGCQDVVNPILPTIPGLPTSLPISIPGLPTSLPISLPITLPTSLPISLPISLVTDAAAAATTSADPLPISLPTSLPISLPTSLPISLPTSLPISLPTSLPISLPTSLPISLPTSLPISLPITLPTSLPISLPISLPIIDSAAPAASSSASDPLTSLPVSLPTSLPVSLPTSLPVSLPTSLPITLPTSLPVSLPTSLPISLPTSLPISLPTSLPISLPTGLPINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI70</accession>
    <name>A0A2G8SI70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI70"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="111" mass="12835" checksum="EEB7CC36FE6E2C34" modified="2018-01-31" version="1">MRAIRARIALSPATHEWLNAVCSVRTLNLDDSKCQASYYSHRAAFIRRFDMASLRSQKRLCAVARRAFRKPERRQGGLTTARNHQLQSPRRALEHISDMEHLRTTYGRDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIL9</accession>
    <name>A0A2G8SIL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIL9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIL9"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.300">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="259" mass="28519" checksum="70D86C5D9EF6C052" modified="2018-01-31" version="1">MDDVGSSIVSFPDSDSHSEADVDLCAESEDSLEDLEDGLESGRSVHFLRQFSATSGGHLSDNPRSGTRISWIVSSLADIAPNLGLPSRSLLLLPQEQSLPPYPKSRYNRRVPDSSSAATSLPHIGQIILSIRTKDQNACVVQQAFCPGFANVNREDYLKLKEDKRVLQDGAYVQYIRPRGNLENNFTRNYDQGGVDEGVDDRGDGPSVSDLHRPRSRVEVSGLYIDLPVFNSPAADPFYPEKETATVHKLEAREVSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIN1</accession>
    <name>A0A2G8SIN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIN1"/>
    <dbReference type="OrthoDB" id="2726860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="241" mass="27330" checksum="198B4322B7DF505E" modified="2018-01-31" version="1">MWVLSTDRAELHYFTGPEVITGGYAILSHTWSPTGEQTLQEVRAIGERCRREGTNPRDHVDAKVRGCCLLAEKEGFRWVWIDSCCIDKTSSTELSESINSMFQWYCQAEVCYAYLADVQGGWALDAQGSPFRKSRWHTRGWTLQELIAPAVVVFFSSEWREIGTKATLAGLLSQITGIPQTVFTRQRLFSNFSIAQRMCWSIGRSTTRLEDEAYSLMGLFGVSIPTNYGEGHNRGSQRCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIU0</accession>
    <name>A0A2G8SIU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIU0"/>
    <dbReference type="OrthoDB" id="2744793at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="221" mass="24429" checksum="23FCCA38FE1B9FEA" modified="2018-01-31" version="1">MFVGFYYRHLPAPVEVLVKHSTIVNALAFSWSAATNVWATAMISYKAWVQRRDLKRHLGSTGLAVHDVLMLLVDFGVIYTVFMLLNVVVLIPSLNGRTFFYYVTLFMQQITGMYPTAIIVLVALQKSHLDHQFTFPPSMHSRTADIETLPFTVKAGHSKETQLGSTTAGTYDSPTSTRYEPEPRVLALRTAGMSVSGSIWENRPGKENGGSATDEGVGLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIV9</accession>
    <name>A0A2G8SIV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIV9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIV9"/>
    <dbReference type="OrthoDB" id="2757721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="37211" checksum="FA0268D004CF4AAF" modified="2018-01-31" version="1">MPLLSLSPDDRRLISASIKAVEDESIIVWDIGDSISQAAVLECPKDLAACAWSPDGALIAAVTFGGTVRVWDGKTLQQLGQLDGMLRDGKMIDLFRCGFEPPDPPWSTCVQFSPDARYLAWALTPRSYHCSIWKPRAGEQPTSLPPHTCDDVTQCESRHTHATPGALAFDPEGRRIATAHEWSYSRPTPEECAVRVWDVATGAILATLTGHTECVMAVSFSPDGSALLSISRDGSVRIWDALSGEHRMTLGGNSAPIAAACFSPCGEYVATGSRWKEQAARLWRMDDGSCVAVFPVFQGCAHHIAFSPNGESLALGTPSGIVHIHRLSDIVGHKTDDCRMLKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ02</accession>
    <name>A0A2G8SJ02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptide hydrolase</fullName>
            <ecNumber evidence="15">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_04367</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="15"/>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ02"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ02"/>
    <dbReference type="OrthoDB" id="76293at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="10 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="649"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="17">
        <location>
            <begin position="132"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="19">
        <location>
            <begin position="431"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="18">
        <location>
            <begin position="781"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL33742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111662" checksum="C7EAD91A040FC9B2" modified="2018-01-31" version="1">MLERLAFPFKFTSSSLTALAVVIYAVLFTTVLLFDDLPRVPSSKGGLDLDQGYEALSTRIFNREGSGHTQAQITTRPHPYISHANDDVRDYILSRLRPLARRHDYIHLSDDLTSNVTFIAAKDHAVYFEGTNVLLKIDGTDPSIGPTADGVLFSCHYDSVSTAPGATDDGMGVATLLQMAEFFAHPTRRPRRTAVFFFNNGEEDQLNGAHAYFEHPWSNLTSTFINLEGAASGGRPVVFRSTSLGVAQSLLHPFVKHPHGNVLTSDAFSTGLIRSSTDYEVYARGIEGEAEGLQGFDFAFYKNRAYYHTPRDSISGMGQGQGRRALWAMMELVQGSALSLLNDDNSGKDSRASVYFDLFGRSLLLFSMDAFFVFNIVFLIVGPISTIGLLAWVVLAAKGQSSVDSISENVAARGVAAKLKLATKALAGWERFWIALIFGALVHALLVAAFMNLNPYVIHSYAYTVLTAFLAASFLVVVLPLQALHYVLPPTFVSQKLAVTLSLFSFSWLLFLASTIAISVKHLGYLYWVSPLYLGAWLATILELVRAGRLGDPGNECGYKSELFTTAEEREAHAEGTISGRRLVHGVVYEAAPQDSERAHTDVGEAETDPTEITPLMHQHRRVSQGGGEYVTLDAPEAVEFTRKPQDEFGWWIAQLVVLVPATVVVVFQLEVLLLNSLAHTLVDGSSPVLVYELLALFSVLVFVPITPFAHKLPRSLNVAVGALLAVLLVGLWAAFPFTQVAPFRIYFQQSIELSASMSSPGPVIPGIGMSSQPPSLAVVHADTTLTGLKRYVDRYIAPGIPSSWTADVSCDPKGLRPDLMTCKWATGLLPSPSGNASLSSTPESAARRVRWLDVETERLNATRALISVRGENTRGCRLYFDRPINYIHVRSSGRHREVGKLQGGYEMPASGVKEARLWSRTWGKTFVVEVGWEQESEAEHSQGQAVLGTGGREEKDGWKARRLSGRAACEWAEYASGTLGGAESGTIPAFEEVKAFLPLWALPTKLVDGLVEVWTRFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ41</accession>
    <name>A0A2G8SJ41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_04418</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ41"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ41"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="53"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL33793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="232" mass="25600" checksum="B21399051D41B8DC" modified="2018-01-31" version="1">MVETESDEILRNADTEDVSLLVVGDPYGATTHTDIVLRARALGIPTRIVHNASIMNAVGACGLQLYNFGQTVSLVFFTDSWRPDSFYDRIRENADLGMHTLVLLDIKVKEQSEENLARGRKIYEPPRYMSIPQAVSQLVEVEDSLKAGTLAPESTLAIALSRVGGGPDERIVAGTLAELLAQPPEVYGEPLHSLIVVGKRLHHLEVEYAERFAVNRETWRDVAGRVYGCALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK52</accession>
    <name>A0A2G8SK52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_03862</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK52"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK52"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="183"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL34151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="590" mass="63928" checksum="8DE9AE83513347DC" modified="2018-01-31" version="1">MLGRPSRPRGRDEEGGASQPLLNDSDEDLPDSDRGPPSHAARPNDSVLFAVDDESDDDNEEGLLGGEEVNKRSHAGEGVRPSHSVRFQEDVQVIAPPLRSTFQSRETEFDLDDDDLDGVALSQLQSNRQDSRSGRRRGEQSMPLLVGLLDASTVRRSIDSPENACSEPRIDLEELAAKRHAGGGMLDSVANMANSILGAGIIGLPYAIRQAGFLTGLVLLLVLCGVTDWTIRLIVVNAKLSGQNSYIGIMDHCFGSSGRAAVSFFQFAFAFGGMCAFGIIIGDTIPHVIRSVFPQLYSIPVLSLLTNRQFVIALCTICVSYPLSLYRDIHKLSRASGLALIGMLIIVTSVLIEGPHVPPELKGNPSARFTILGDGVFQAIGVISFAFVCHHNSLLIYGSLRTPTLDRFNKVTHISTAISLVACCTLAISAYVVFTDKTQGNILNNFGPFDTLINVARFCFGLNMFTTLPLELFVCREVIEQYFFPHEPFNMQRHVFFTTAILCSSMIIAIITCDLGVMLEITGGASATALAFIFPAMCYIKLSAPHEPWYSRSKLPAVVCATFGVVVLCISLFLALGKAWTPAGSATICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKX5</accession>
    <name>A0A2G8SKX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_03189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKX5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKX5"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL34414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="573" mass="63862" checksum="E79C43DFF325CD80" modified="2018-01-31" version="1">MVQLHIPVTSLHPSLASAFLALAVHQVFRTHETYSVVVHCILLVVPPTLVFSTTISVLVDPPSVPWTLVLCYGTYLLTLIASVVLYRVSPAHPLASYPGPFWCRISKLWLATVAATGKQSRWFAALHDKYGDVVRVGPNELSIRDTSLVARCMGPSGIPKGPNFIGGRLSAADIPLVGIQDVGEHMRRRRPWARGLSTSALKAYQPLISKRTQQLVNRLEGQPGTIRFERWFDWFSYDLMTDMAFGGDSNQLQDGDTDNFRKMLEDGVVIGAFFSHVPHIAVWMGLIASAVAPLDALTKYGASRATRRLAQDSKRQDLFHFLNNEDLPDKAPPPASELVLDAMLVIVAGSDTVASALTSLFFCLLANPRTYAALQEEVDRYYPRGEDAHTATHHRDMPYLHAVIQETLRLFPPLPTGSGRQVPHDSNDFNAGTMMLPPGTQVYFSPWVLHRDPRNFSFHTEFWPERWLVASGHISLDGNTPGLPAPFQSCSQSDAKSEFKHNDAAFLAFSHGPMSCVGKGFAMQEMKTVVCALMQRFRFQLKEGWDPREFEASYLEYFVSSRPALPVTLTPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLD7</accession>
    <name>A0A2G8SLD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLD7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLD7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="373" mass="42133" checksum="04C408E0B555D6BA" modified="2018-01-31" version="1">MLPSSVPSSKTMRPDSLHVLAPTLAPSSRLTAKRNGSSNLSWTVVDAGAGGNTFVRPHGWFTRDHFESFSETIASSSYLAIGSLVKIIHCDLKQLIRIGDVVQAPLPMHVVRRFVNLKSLTVVADSIVPFRPSFVGFLKYFSVCDTLDSLYIRRGCYFIAFEHLAGLGAVLSFRHIKSLQTRQSIWFSRGSMNWSDYPGFTRLSNVKLCLSVDMDSLYSLLSSTVEHLSVWEVERPGMHETYHAWEVARLKSLKSLELTFAQEDIHWVVRTLVNNGSRVLETVSFNYLSIDVDQTPETVQHQLTEQVIDGILRASRPFASVTRVVVKLFANDPSNEGERWSKAVQAALCRTHELKMLHFSVHQYTAADWDRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLE8</accession>
    <name>A0A2G8SLE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLE8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLE8"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54411" checksum="B233E781B0572276" modified="2018-01-31" version="1">MVEANSTLCPSDNLSVIDQSSFWDSNGLNWDAHRIGWLIAGVCAAVTVVLTIVSVSFHCRNYTNPSEQRQIIRILYMPAVYALISFFSYRFFRSYTYYDLIECVYEASSLPTLLPFHRSFPHFLPPLEDLDSDTSCLQSVTLSAFLLLLIEYVASTATGHDVDNAILRKEKSSLPLPFCCWRYRPTKAYFMYTVKWSVLQYVILRPALSIAGIICEHYGVLCQSGPWSFKTAHAYFSVIDFISISVALYGLLLFYGLTKDELVGRKPLSKFLSIKLIVMFTFYQSFVFSALEGKVIKQSQYWTATNIADGLNALTICIEMVLFSAFMMYAYTWKEYVVPGRPTTGFGRPLLDSINYADFAQEIGSSLKFFVDYVRRKPGTHGARVTVTDMHGNTVAKKTYGEAFGFERSASGVSTLSGGGYRVREGGGGGGGGGGGGGGESMSMSAVRAPRESFEENVRLAPYTYGSANGSSSEGLGHLNGPSTENVSVPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM09</accession>
    <name>A0A2G8SM09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase jelly roll domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02579</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM09"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM09"/>
    <dbReference type="OrthoDB" id="3242985at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-galactosidase jelly roll" evidence="3">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="151" mass="16220" checksum="ACE87AFF2C898A6F" modified="2018-01-31" version="1">MNEGGLFGEREGWHLPGFDTGSWASRELSEGLPGGGAGFGFFVTTFDLAFPENTDVLVSFQFEAENTQPYRALLFVNGWKFGKRVANLGPQTKFPVPPGILDHNGKNTVAVALWALDNTAVSPSLELVIDSVLDGGVGPIATNNPVWEPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMH9</accession>
    <name>A0A2G8SMH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMH9"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="338" mass="37010" checksum="7D1C0BFF8018DADD" modified="2018-01-31" version="1">MASVFSHWKQTAWPVLAQLWPPASKFNVDQIPDLAGRIAIVTGGNSGCGYETIKASLPLHRPLSLDVGCLTHNAKVYLAARSKQNADAAIASLKAETGREPVFLEVNLASLASVKKAAQEFLSKESELHILFCNAGVLTPPIDQLTEDGYDLQFGTTVVGHFYLTKLLMSALLAGVLTSPDHHVRVVATASMAAYMETLHYDTFRDGAARRRLGTVKLYNQSKHGNAVLARQVAKRYADRGIVSIAVNPGNFKTNLTRHTPSLVTKFLGMTVLYPAPYGALTPLFAGTMPEALNYNGEFMIPWARLGKCRPEVYDDEVGNKLWNWLEGEVRAFEASHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMP6</accession>
    <name>A0A2G8SMP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_02834</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMP6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMP6"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013668109" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="225"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL35047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="636" mass="68219" checksum="347316DFB4E8B93E" modified="2018-01-31" version="1">MHLSSLAWALALASLAVAAPSRRSNLVVHERRAQEPRDWVLTRRLDSGAVLPMRFGLAQSNMHKVEEMLMSVAHPSSPTYGQHFSMKEIVDTFAPSTETVEHVVNWLVGEGIDKKRLKLSPSKGWIEFDATAEEAEGLLDAEYHVYTHAETGAQQIGCHSYSVPEDIREHIDLIKPTVHFLHRVPTPNQLRKRSFERPSTHIKSGLKTDGSLADVPADLANCDQLITLDCLRALYSIDYTPVSTDKNTFGILEFTPQAFLQSDLDMFFANFSPSQVGTKPILISIDGGVDQTQDTGFNFNGESDLDLEYAFGLTNPQPILLLQTGDIPEGASFDNWLDAVDASFCTFEGGDDPTQDGIYPDPLPGGFDQPESCGILTPPFVISTSYGQDESSVTAAYAQRQCTEYAKLGMLGSTVLYSSGDNGVAGNGGICLDGDGNPVENGSQFNPDFPVTCPFVTAVGATQVNPGSTVDDPEGACEQVIFSGGGFSNFFAMPDYQAAAVTSFLTNHPPPFSGEQFNNSGVARGFPDLSANGANYVVAVAGEFERVFGTSCSSPVVGSMITLINDARIAAGKGPVGFINPVIYTDKFQAAFHDITTGGNQGCGTPGFTSTEGWDPVTGVGTPNFTALLPLFLELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMV5</accession>
    <name>A0A2G8SMV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMV5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="197" mass="20672" checksum="54F37B172761FD8A" modified="2018-01-31" version="1">MAPFAPETSVQTGTSILPKLLIVILGSSVIFLAIIIGFSFASKKGCPPRPSSTSDCRQFVPDSSGCQHTHLHHPPARRGLALPVASIPRCFACQNGYGTAAKASRFSHVPSRSLQAPSPYHSRRAAPTGVLPNTQSRSGRPASSGSPPATPITIPPSPRPGYGARGPTATLRPAADRARPDSAMQHPVHNFSESLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMX5</accession>
    <name>A0A2G8SMX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMX5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMX5"/>
    <dbReference type="OrthoDB" id="2754894at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836176" description="Transporter" evidence="3">
        <location>
            <begin position="25"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="35387" checksum="24B30B8006D287F7" modified="2018-01-31" version="1">MSAAFLIPFTAATFLLSCVPGAAAQGTNATCNPGFEWMTNSKNQNPCLVSSFLFTPCSSPSDSFVFPLTPGFHYNTPLNSTTSATPCRCNTVLFSTIAACATCQGGADDIVPWFMYSQNCSSVFIQQYPENIPSGTAVPAWAYLDILVNGTFDPTAAEAVAAENLPESTALPAASQTLGTNTNNPTFQTTVRGGTASGEPTSVGDNSGSGSKKSNAGAIAGGVVGALVGLALIAAAVFYVLRLRSRRGAAAGSTTQNYGAVYGANMQSWEKSPVVPMSTHKFYDPNDPRTFPGQDPYARGPGQASLTHLAASIGADSSNLNDPYRSVTLANPNAYRGVPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN72</accession>
    <name>A0A2G8SN72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN72"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN72"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="338" mass="37847" checksum="1E3E86F47BD2A9C6" modified="2018-01-31" version="1">MCRWFAYISTSEPCLLEDVLISPDHAIAKQVHDRYLPYLTHYEPDTTPEEMKLRNSPFNLDGIGVVWYTHARAAFGECEGPRPVTYKILRQPTTDPVFQSLCAGTTAHCVFAHIRAASGATAITHYNNHPFTFGRLSFMHNGSVAHFDEIKRALALELSDAAHARVKGTTDSEALAALFFTYLEQQRGPGVWEEAHPLEEMKACLEKAIRRVLELQRAAMAGVGKTPDASSLNIAITDGEQLLAIRFRNHEKEHPPSLYLSTRAGISLNRKFPGHPDREGADNGLRNLKAVEEHGDHVIVASEPTTFKKEDWKLIMKNQCIMVGRDMVVRHAPVEVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNL4</accession>
    <name>A0A2G8SNL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNL4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="325" mass="35246" checksum="5A3C8D96D1B7D909" modified="2018-01-31" version="1">MLVEEGEGGRAIWEGDRRLCEEEARPLQSEVLSPVRDARVFALPRGADGMCALDPDLVHDGLREEDVPVGGVLHEEAVLDNLAHHLVVRQAAGQEEGEDEGAVECRRRELVKEFRHLVHAVQDLRYTCNAEVGRRGKGQMSVCSDDRDHVSRNISPMMCLVVSIGDLVDLIPPDIPGCGDGAIAIPAGTSKPPASDAANNAGFLTSSSDLPVALSRSSRSIASPRRMSSRMLRLPLWSSVDFQCARAEISAIASSASSGQPESPSMRSSECCALDIGLRPLLAQKPAPPPKSRLYSDRKRGGCMSVMLEKMSEYCSRLARNTHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPU9</accession>
    <name>A0A2G8SPU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPU9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPU9"/>
    <dbReference type="OrthoDB" id="2348945at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="475" mass="50205" checksum="937621DF8CED01EA" modified="2018-01-31" version="1">MDNPQYYQPLSHALHAPVVATSHSSPRQSYSHYTPHQQPPVTNGAGSSHREEEEEEDDDDEEVVEEELDHHDADHPHQSASSHSSPRVNAAQSQSSSAGAAATTASADYRQPAPQQEQTLSAANDDGTEKRRPGRPRGSRNRKPRVSSGSATKAPANSQHPGFYQYPPAPGANMSQQNQQFYEFQWRALNLCSEFYNAAEELVKAASPMVIAQCYQMGPATKIDPLMMIADAKRVCDNLLANPSQLVGQPVPTTTYPTYSSMPPPPPPGAAAAAGPAPAAGSVITNPQTFVMPLNSSVPPPSQPYYPAMYPPPAGSRYPTAPYYYPPPQGATPYYPPAPAQPAPAASPPAAQPPTPTPAPASAPAPAPAPAPAPAPAPAPVPVAAPPPPLPTHAVPQASPPAASPPIPTNTGTISTFNAATGNTAPGGHQGTWSEEETDRLRRLADQSKEMGGPQNKGEIEWDWVIQQWGNSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ27</accession>
    <name>A0A2G8SQ27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaminase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ27"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ27"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="290" mass="31646" checksum="7F7FFBB74ED4C632" modified="2018-01-31" version="1">MQAGPMNVTITFLSPVEPDDWVKQSIPFSYLSVEARSLDGQSYPVQLYSDITTEWESGDRTNSVVQWSNANTGSSIYHKVLLQNPQQNVEIANQAQDGTTYYAMPTSQPGISWQIDLASTARDGFQTNGKLTNTAWTAFATIQPNFSVFAFAVDVGTIQSTASPVTWSVGYVRNTSITYTTPGGAVQQRKPYYMTQYKSVEDVIDAFTGDYAAAYNRAVTLDQKIMNDATKISSQYSDIVSLATRQAMGTLDITAGTDSDGNLIPGDVKVFMKNLGTDQFVLSFTSGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQM5</accession>
    <name>A0A2G8SQM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase C15, pyroglutamyl peptidase I-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_01731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQM5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQM5"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL36071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35523" checksum="E09300E6DD453ABF" modified="2018-01-31" version="1">MPPIVPATDGIDPNALRVLVTGFGPWGRYAENPSWLAVKSLHNTILYKDPPAELLLHTENAIVTDEMEELLRRPQQIHITALEIPVSYQAVLGTVPGLHGRPPVLPSPNDPSFAIPPPPANGYDFIFHVGVAGRGPLRIERIGHKNGYRMKDGDGEYAPIVHLPKDTIGNDAEAELARMERMLAGTIDVPGLPMAPSGAEVVDIPPAPNRGFGKGYETFADELSTEIDVPKLIVHLKENGIDQVYSSMDAGHYLCDFIFYCSLAEAKRLVAPQEKFKERNTPIKSTPVLFMHCPPVDQPLSSEQVTDAIQRVILWVCGRFHQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQP3</accession>
    <name>A0A2G8SQP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQP3"/>
    <dbReference type="OrthoDB" id="2757435at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1017" mass="112332" checksum="0571522855846A11" modified="2018-01-31" version="1">MSSPSLLGPRGSCHHVSCFNDANPCGYFIVMSNGAENVVPNSATDLCAACDHPWFSHLLEALPPDHPAPGQQRGVYQSFGPDGCDSANCGGFYSHGIYPQLKAQSPTEWTFTSLCACGRMHRTHAPFRPFTNSGHTIGIIASPFGVRQGRSSAPAPFVSSASIAQQAPIAAYQGVRSEVSGSTNAQRVDAYIRHRPQSSSSGNIPHARTTTLSGGGATSNPFALSCVTGTSLSASSTISPSRRPRNTASAPAPTQVAAISNPDIVDICVILIPHVDPAHAPPSDPYLQQGRACEGFKWDGSQFAILVEELLHFKLVFKVSLPTNGTVWRDFHDAVLLHLSQNALEIPEFSERSQSPTGPHNICFRLIATTTKNRPDSSRIYKAYDDLPASEWKAAQFSELPFKNIRWPLDGEMSALNVVIIAPRSQNLRSILPFIRPRPHEAWDDHSTQIQNSPPTAGPSNATVVHADIAQEPECTDGGSESSFSSTDTQSEPPSKHARLDSGDDAEPSRHRLDNLPGVIPVVSKSQDDLKDWATSIQSSVPADNTRNNIPSITAPSIEVGAQVLYFLVYWNFQHMSNSPELRAQEARVFKRELEIRFCDPTVSCNLVALATLIRSAQRLDLTIGSAIGQGVTRNLLRETIQVALRIPNLWQDRGRYSTIQFLPYIPPQDRILHFMSCGFLCVLHIVALEIGPEPISPFLLRAAIEEVEGALQIDTALLRLLAPEDFETLLPWITHDRSVPLAADITSKVATLLMASEINPAWVSTSADVLSQMERHLFSQTMFGHGDIFMHADFREFTKGINFITTLTYPANKLVMSFRGETRNYLAAMYNRRLSDVSVLLDHIEFRSNLDRVAIAKAEECSDADLSDEAWDIVYEDIFEARLKVYLRGVGHPNTQDMRNIIPSAEFDAARHDHLLRARYFLHAMTGSDLVPAASDWKISIFFHHKGERVNFVPPPHVPVPDPERMHIHACFGQADVHIDDGQRNLLVQPTLHRRPIYFADWIHATVMNPKDFNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQW3</accession>
    <name>A0A2G8SQW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQW3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQW3"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="373" mass="40716" checksum="873FA317DFA66B9B" modified="2018-01-31" version="1">MSTALSLIYALCSPHILSSPPDRIPWHTSDIPNLSGKVALITGGTQGKGFEIAKTLAYAKARVLILARDEDRPDIALLQIKRHCRVHEKFVPDVRFIQCDLANLSDVKRVGDELCELESRLDVVVCDAGVGIQAFDVSADGIDRHFAITHLAHFLLINRLLPLLRRTASTLPPHRSPPTSPTPSRTSTRSRAPRAPRIICLTSNLHSVSSRSVQFISNAELSFESGSAQSPLALYARAKLATVLFVRALARHLGQDVLAVAVDPGAVHPDQSNQLLKAYGPLWGSALRALTGPFERSVSGASLTALWAATGLRVEHGEEVWERWQGAYVSAVGVVGGESEMARDEGREAQLWKMSEDLAKRRLGNDALRPWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR62</accession>
    <name>A0A2G8SR62_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_01728</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR62"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR62"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="12">
        <location>
            <begin position="389"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL36068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="516" mass="57300" checksum="8300AED820893CE8" modified="2018-01-31" version="1">MDFDESSNKIVTREFLAVVLAGFGNELIPLTSNHGDEPSPKALLSIANKPMIEYSLSWIEKSGITDVLLICPTSHRSAMSNYIQSDSSSFPTLRIDLQTYEESQDLAVGTCTLLRHFSSRIQSDFIVLPCDFVPPPALSLTQLLNKFRTETTYDGSIATTCFYEATRADKSTVTEEWGILPTNVPIVFDERSGTLLHVDTPEDADKNNEEFELRMSLLSKYPRTRLSSSFRDSHVYVCKRTVLEALVEKAHLDSIRDEFIPWLCKPQYQQTRREKYGNILSPVSNNVSQGLALKHSTLHLPAKNDRLRQSELDHELVDEHLRSVVPSPVDDLDEHAVEPSLRVGLVVHRASSGFALRANNLHSYLDLNRFFLGQTAYTLPSDPESRSLIDQKAQISGDSMIGRSTKVEERASIKRSVIGKHCVIGKMAKIVGCVILDHCVIADGAKLEGCILGAYTKVGAKADLSRCVTQPSYEVAAGESAKAEKLEVSDWTAHETSEDQDSGDDDDDESTEDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRG5</accession>
    <name>A0A2G8SRG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="3">M1Pi</shortName>
            <shortName evidence="3">MTR-1-P isomerase</shortName>
            <ecNumber evidence="3">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MRI1</name>
        <name evidence="4" type="ORF">GSI_01828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRG5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRG5"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000006">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="386" mass="41323" checksum="F942611C9346AB1B" modified="2018-01-31" version="1">MLDFSSIRTSEGKLEIVNQLLLPHTTEYIEIKSIDDAFDGIKSMKIRGAPAIASLASLAVADYLARALATSPSPDWLETTDAFKQHLEAILAHLFTARPTAVNLGAATRRLSNKLQTLIDAGKNADTIARELISEAKNIDAEDVGRNKLMSKWGGEWLVERVKTQGGSDTDLNVMTVCNTGSLATSGYGTALGLITYLHETGKLQRAFFTQSTPYHQGSRLTAFELKSLNIPSTMLCDSMVGSLFQHHNIHAIAVGADRVARNGDTANKIGTYNAAVLAARHNIPFIVVAPVSTVDLEVPDGSGIPIEHRPAIEACLVRGALYPTTLNGEGAKEQATVMVTPEGLEGVYNPSFDVTPASLITAIVTEKGVAVKKSGEEVFDLTPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRW8</accession>
    <name>A0A2G8SRW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspergillopepsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRW8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRW8"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013970383" description="Aspergillopepsin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="28820" checksum="A67B3F39206809EF" modified="2018-01-31" version="1">MFSAALFCQILLATAAFAIPSSKDSLAARIARRNAGLTHQSHPNQLVESPFPAEVTEVDAATNGTTAKVSYSGNWAGAVLSAKNATYKTVTGTFVVPHPKEPSGATGRHSAAAWVGIDGASCGKAILQTGLDITVNGSDVNYYAWYEWFPAPWTDFTGITFKAGDTVIVSVTATSKTSGKATVTNKSTGKSVSHTFTGQPDLCEEDAEWIVEDFSSGGKLVPFADFGKVEFTDATVTTLAGKTVGPAGATLVDLVHNKTVLTKASTGARSVTVSYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS62</accession>
    <name>A0A2G8SS62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS62"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS62"/>
    <dbReference type="OrthoDB" id="74813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="341" mass="36848" checksum="AF4A747202E36A32" modified="2018-01-31" version="1">MYERLVLTAEPTSVNETPLGVRTHTLESAISTVSTPSEEREPEQPSKKDRKGKGRAHDEEAGAEAPVFMMASLSNKNKRRGFKDALTRGIPPKITFADPEAAQSASNSGQGSTATAQMDADADALVVEASLRVQDTMPQRTRQPKPRLIPPSDKQELGLLPPNMFVTSVDVEEGMWSKRKNKKKKKKVPVEEAWDQEADETFEEGLPYDDESAQAFSAVQTSTANAVATQVGHGEAVERAVVAARWDSLRKIADKSQVAVGTVVAWKALGINVATLTPEMLLNVAHAVQCDDQLVVAHMAEAGGGEASFGGVVADEEDGAAEEIFEWTDVLQGDWRLVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSL2</accession>
    <name>A0A2G8SSL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSL2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSL2"/>
    <dbReference type="OrthoDB" id="3233824at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="278" mass="29975" checksum="5C78F82E2B4142B6" modified="2018-01-31" version="1">MTTLPSFVELMASLGLGGPDDAPEPTKLSVHHSRSSSHSSTASAFSAASSSSNVPSASSNIYPPHQHQLQHKHSSPAIVVSSHEGSPERDMPQDIRRSRATTRYSPYGSVNHSRKASMPTLNAERTLERPARALSTSPRLSPISASFRGRRSRRPENLTLSDADLMANTPISSYLRRRTPQNSPTSPTFARDRDAAVSHPLTIPALPTLLSPASFATQSSDSEDDEMEGVPEPEFQLGQPQPHISGTSPLWQSRYCDSPVSPRISVCAPISPEIVPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSL4</accession>
    <name>A0A2G8SSL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_00433</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSL4"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="34"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="297"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="11">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL36744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="417" mass="43806" checksum="04B479ED1EE0C373" modified="2018-01-31" version="1">MFLARLTISAPASRPFLRHLARNMSSSVQRHEAVIVAASRTPVGSINGSLKTLTAPQLGSIALTHAFEKSGVKPELVEEVYFGNVVQAGVGQSPARQVALGAGVPSRSDATTINKVCASGLKSIMLAAQTIETGYKSVVVAGGMESMSNAPFLIPRTNPAYGKFTALDSLENDALWDVYNKFAMGVCGESAAEKHGITREAQDAHAIESYKRAERAWKAGQFKEEIAPVTIKGKKGDTIVAEDEEYKRVIYEKIPTLNPSFKKNGGTITPANSSSLNDGASALILMSAEKARELGIKPLAKVISYADAGVDPVDFPEAPTFALPTALERAGLKVDDIAQFEINEAFSVVVRIAEKKLGIDPAKINPHGGAVALGHAVGNSGSRIIVTLVHSLKSGEYGAAGICNGGGAASALVIQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST80</accession>
    <name>A0A2G8ST80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST80"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="117" mass="13382" checksum="66F0B12D3DFC7BC4" modified="2018-01-31" version="1">MPCIPNPLSHALLSLAFRCLTHVHLVSRSRYPLPPCQSRPRSCTSPNSLPHFVLFSSSPSSHCPSRRYLASRSLVQRGAWRTGTHAYTHLAYFSYYLRARNVLYAAVYFYHRLACRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STA8</accession>
    <name>A0A2G8STA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_00634</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STA8"/>
    <dbReference type="STRING" id="1077348.A0A2G8STA8"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="302"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="505"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="655"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="931" mass="101668" checksum="D717EE52E3892DF4" modified="2018-01-31" version="1">MITFTPLSGAARSDHTAPLAYVLQVDDVRILLDCGSPDWCPEATKGETEEGDGPAWEKYCDSLKECAPSVDLVLLSHGDLSHSGLYPYAHANWGLTAPAYTTLPVQAMARVAASEDVEGIRDEQDVGDNPPADSALEAGGDIPGSPTPYDAASPTSSSGTKRRKYVATLQQVVDAFDSVNVLRYSQPCHLQGKCQGLTIIPFNSGHSLGGTIWKIRSPSAGTILYAVDMNHMRERHLDGTVLIRQASAGGGVFESLARPDLLITDAERASVTTARRKDRDAALLGKSIASPTLMNFIGHSLVLELLVLLDQHWNFSRLKYPICLLSRTGQEMLTFIRSMMEWFGGTISKEDVGENGTDGRRDRRRRDDDHDEEALGAFALRHVEFFLSPQALTSTYSSKDPKLILAVPATLSHGPSRMIFAEFAEIPDNVVLLTGRSEPGTLGRVLFDKWNDSQREEAKWDRGKIGSNIMMDGVLRLEMHSKVPLQGAELEEFLTKERAAREKAAAQQAALARNQRMLEADEAESESDDESDSSNSDSEEENEVERTLGEDLMDTAEEGAKPARNGRAKRKRGQGVDADGDWAMGGNEPDEGVTRISFDIYLKGNVAKTTSFFKSAEGQTQRFRMFPYVEKKRRVDEYGETVDVGMWLRKGKALEEDTESEEVKEAKKRKEEEEAKKTPREPPSKFVTTIAEVQLACRLFFVDLEGLNDGRAVKTIVPQVNPRKMILVHAPATATDALIESCANIKAMTKEIYAPAQGDTVQIGQHTNSFSISLSDELLASLKMSRFEDNEVGYVSGRVSSLASSTIPVLEPAAISHFQSASTLHQPLRGRTLGSRPTQSLPQSTMIGELKLTALKTRLASIGVQAELVGEGVLICGAAAKKGASITLDSLGDSVAVRKTARGRVEVEGSVSDVYYVVRREVYSLLALVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STX5</accession>
    <name>A0A2G8STX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_00924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STX5"/>
    <dbReference type="STRING" id="1077348.A0A2G8STX5"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="619"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL37231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="926" mass="101448" checksum="C6C09BDD95A5E0FE" modified="2018-01-31" version="1">MGFRKILKKWDKRSRSTTKELYLARQVEVQPVFNRQLISELADTVAACLLDMTDLSVGLGNELYVAEDIILSHQLNIDRNVQMAPFYDLESNLRKALADGDRTVIADLVRFSDSLAQSREARNHVTRILWKAVIDAPQEPADLILSSTSRPFDYTFVDDINGRTCLHEAAIAGQLRLVDLCLTGGVQSDKTDAYGRSALHYAAMHGHGDICRRLIQVGLPPDIVDVDNCTPLIYATLKGCVDCVRAFLEDGKVSVQTPSSNSDLMPLTLAARSGHMDVVVLLLQYGAPSLPNTNGEYPIHLAAQEGHAEVVRILARRDGWDVPDKYNEWTPLFHAARFGRESCLTVLLEVGSRIDVTDEAGNSPMYYAAWYGHRTCVALLVQAAAKAQAAQVPMAQDSPLTDTQRSSGTESDIDAIPSLYLPPPMMPYRVYGHNYLDKASLVQVTIGHLSTHYQDESVEGPAVRLRHPLAGPQYEDRHLHASPLLKIVMTAAPVTTSAPYSIPLPIRDQKIVFSFQVPSPSALSLEFSLYPNFGTKTIGRATGLPHLFQNIQNSQPFTLPILDPRLHVIGEVSFEVNIITPFGGVKLEIGGAVETYWKSLAMPVPGGSSAKLLTPRPPQQPGRTLGSAQTSPSTQTLAQAFGHSLTHSSVTGSYIYVTVQVTRDQHPVVFPEWRLPDESYELGVADVTLSQFQSLAVRLGRGRAPPDASSPPSLWARWIASSMISMQELLRIVPAAFGVCVEIAYAPARVRRRHSLRNQLDLNDAVNSVLRTVYDTSALEGTFSRRPVVFTSFAPDVCAALNWKQPNYPVFLASQCGEVHRAPPSATALSTDDVHDHRLWSLDAAVESAKMNNLLGVLLDARLLAQVPSLIQGVKDFGLVVGTYGLREDTEKLPTTAGTEANGVDATLHDGVLIYFNHTLRGMQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU98</accession>
    <name>A0A2G8SU98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01044</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU98"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU98"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL37351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="219" mass="24660" checksum="90910B49643100DF" modified="2018-01-31" version="1">MSFARALVAAGPSTRLAAGRVTASRSLALAYRWHSTTPRLQQAEPLKHKDHLEPGPPIRSPSSKTASFTAADEPGKDYDPYKDGPSAIDKAVHLFFFTEIIRGHGVGMWLVLEQFFRPPYTIMYPFEKGPLSPRFRGEHALRRYPSGEERCIDIDMTKCIYCGFCQEACPVDAIVETQNQEFSTETREELLYNKEKLLANGDRAEAEIAANLHADHVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUW6</accession>
    <name>A0A2G8SUW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUW6"/>
    <dbReference type="OrthoDB" id="3350619at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32158" checksum="BC23F2E052F94E34" modified="2018-01-31" version="1">MIFQSSSPASSSSSAYAPLLHSDPDSQDDIALLEHDVQSKERPSEEQRSVTRRLSPMVYWACALSLLCSAFNISLLGLNVLSPQASPSPSPPLEYGNSYVGLEAAVRDPSAPPLRPITTFPTGIAQVNESDPRAVYYDVHRWASTFGTVYPEDRRVLSSSTESTYIQFWAGDFGMERCALKLLLPGPSSESPHDVVLPTPDAALQIWHVDTSRGGGLDFHRLSWRSRPARGALLASWILRDNATLESEVFRCPSGSFQAFELGCAGKGCRVDFRQTPKRKDLGFWLVQRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVI0</accession>
    <name>A0A2G8SVI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01292</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Cd(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48775"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent cation per subunit. The enzyme is active with manganese, cobalt or cadmium ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-II DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVI0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SVI0"/>
    <dbReference type="OrthoDB" id="2338at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002480">
        <property type="entry name" value="DAHP_synth_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337:SF0">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21337">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01474">
        <property type="entry name" value="DAHP_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0104">Cadmium</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL37598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="486" mass="53622" checksum="E5FF457224786441" modified="2018-01-31" version="1">MSDSSWTPSSWRSKPAAQIERLRTQLTQVQNNRAFLLHAGDCAESFDACTHENISNKIGLILSFSLIVIWGARMPVVRIGRIAGQYAKPRSSPTEKIGDRVVMSFRGDNVNGLDPDDRTPDPDRMLSAYFHSTTTLNHVRSLLTSGFASLHHPKDWSLTHVRSPALREEFERITEGLSDALEFTRTIGLGKESLSYEQGGGRGALGEVDFFTSHEGLMLDFEEAMTREFAIPSSLASRSADADADGTRTPPPRAHYNTSAHFLWVGDRTRQLDGAHVEYFRGIRNPIGVKVGPSMQAGELVRLLDVVNPEREDGKVTLITRYGAGKVEECLPGQIRAVQESGHPVIWISDPMHGKLLNKLHWARDSTLTSSTGLKTRNFGTIISELTSALRIHAACGSRLGGVSLEFTGELADDGFSVTECLGGSMKLSEDQLPLRYQSFCDPRLNFEQSLDVAFLISDHFKKERTGAKTSYGDVLYSELGGRKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVS9</accession>
    <name>A0A2G8SVS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVS9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SVS9"/>
    <dbReference type="OrthoDB" id="3162524at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47561:SF1">
        <property type="entry name" value="POLYSACCHARIDE DEACETYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G05030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="26466" checksum="E9A5F74DE80FD5F7" modified="2018-01-31" version="1">MEGASAPAVRDAGHEIGLHGYSHENPVSLTLEQQRDILDHTYNLLTEFNNGVPPKGSMAPWWETSKEGTALLLEKGIEYDHSNMAHDSQAFYLRDQDLWTKIDYKAKAEAWMKPLVRGKATGLVEIPANWYLDDLPPLMFIKSSPNSHGWVNTRDVEQLWKDMFTYLYREEENFIFPITIHPDVSGRPHVLLMLERFIEWVNTHADVHWVPMIDMANEFRARVARPPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLJ6</accession>
    <name>A0A2G8RLJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_15068</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLJ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLJ6"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL22380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="426" mass="46947" checksum="9F7D4F9CEADCF8CE" modified="2018-01-31" version="1">MSGSRTRKFSGEEKEQLLANLDLEGKSPPALHQSLHVEHLPCDIVAHKTRQFEEWLVDTLEDFRRHQESLISRMPRIVRNVTLREFAKYKGDIQAAVKGLSRELLGSEDATIDLTTRKRKWVESQEADGDKVGKEESSRGVKNARTVAATPKKKPSSSVVPQSAQKSRLPITKTPAKTRNMTRIPSGAVSPSPQKGVPKPLGFPRTPSRFASPTKASQGRVPTSRVPSSSTFNPVLPSEASHLRWPRKDERLRSVNGSPIANPYQLDLKNWFKAIAEEPESGDQLRFNAVGGAGKTLKKQRSIIIRSGSSSSLGVGSQHGTHSRSASQTSTLVGTHSPIDEQYGKEQRKGSTVSERVSLEDPFIASTFSALVSVHTKDGHVLEFNPLQTSPEELDALEGISDSAKKQAKEDMARMIQATLERWRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLZ7</accession>
    <name>A0A2G8RLZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLZ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLZ7"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="80" mass="9311" checksum="5C41C1265E153F4A" modified="2018-01-31" version="1">MDRLCVGNSRLDAIDEILQLILNELSHPAPFAILSKRHYEFAKDPYIRAMYFLARHGRIQALYWALGRGKLLNERVLDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM53</accession>
    <name>A0A2G8RM53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM53"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM53"/>
    <dbReference type="OrthoDB" id="2745837at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="798" mass="89166" checksum="777FB00A2B89CD65" modified="2018-01-31" version="1">MTLVSITAPSSPTKALRQNSAATRKFTRQDARAELRSTMRRKATIVTLEEMMRDFLTPLAKGSKAIPNVFTKVPKFGSEKEMYEYITKTLNESDQFTRTGMMFVTTGYKPDKNDDSKQTIDCGMYASKLAPQEEYTESGEESRRMVWALIELLIECKLDGVGQDPFDDSTEGGEVTAEKRREVLGQILSYVELAFKYQQREAVFMVLFLGKYARVVRFDRSGIIASEKVDYKKDGEGLTEFLVRYARLGPAKRGHDTTAFRISPADPLWEKLKEHGAAAAEKDTEDHVQKLFNQSLDEKWPWWKLYVHDEESDKTKWFAVGKPHFYAGGVAGRGTRGYVAVPLDDDGEKIDSKATFVYLKDAWRVDHEGMEMEGTILKALNAAKVQYVPTLLYHGDLNQSTQSYDKWPDYHKDNTRETCPLKSHQHYRLVVAEVGKPLSEFENAFQLVWALFCCITAHEQACAAGYIHRDISAGNILLYKDENGEWSGLLNDWELSKECVDWELSKECVDWKTQGGGRQLDRTGTWQFMSVHALLKNTKLIEIPDDLESFFHVLVYFAVRFLPHNLADKLVGHFLYSYFDDYSDGEPGFICGPLKYNAIKRGVIDLTTITGSGGGDEAQTEQPLMFLEPYPAAAAPLDDMDTTENGKSVAAKTHPVNALVTDLLRAFQAFYARDAPEVPEQAAFDDPFGIAPGVLAKLKRRKAQKAALAGTSGAKPPSVMGYPTVDPEVAAKIESHAAILDVITDHLTGSTWPKLDKGEDKKPKGGYVPAKENTIVGSKRGAQDGGESTSKRVRSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMW2</accession>
    <name>A0A2G8RMW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMW2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMW2"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="65"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="155"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="220" mass="23237" checksum="75FF473AEB6B578E" modified="2018-01-31" version="1">MRVLQDCTGTRHGGRGHQHSDSLSASVSRTSSVLSRSDSSISSLQAVTPTPSSFAPSPSTHAAEERGPVARVLFDFTPTSPFELAVSAESTVHVLEEDDGSGWVKVADDSGGKGLVPASYIEFHEPGGAQTQTQAQAQARSTTPSLSRPRATATANADYVRGIYAYQAQGPDEIDVQDGGLIQLTEGPNGGRRYGEGWWEGIDASGKQGIFPSNYVEDVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN85</accession>
    <name>A0A2G8RN85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN85"/>
    <dbReference type="OrthoDB" id="2800028at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="241" mass="26912" checksum="54FC2C469BE89E24" modified="2018-01-31" version="1">MSRPSQPQDSQLQPTSTHGQEGDTQTPPVAHCTFDEHIMSLIPTYKPLSKDGLRDFLFSFGATEDTLDAYLASYNRIAEDSMQRGGFRVIGVKPQPGDPNVYTVRVPDSPYCLRMWAGGMDYWGQFCLDFFDVERKVPVNLPLGHALFPGMSSMPPGIGAGHPLPAHLAHANMQPPTSYPLCSWERNMGMQSIPDGEEKWAIPEGMPVMLRRDGHPDFMFQMPRRQAPVVLAQPQMGYPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNC0</accession>
    <name>A0A2G8RNC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNC0"/>
    <dbReference type="OrthoDB" id="2765179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="260" mass="28787" checksum="781C58916FA9EC98" modified="2018-01-31" version="1">MPMLSSPQFLPPVPAPGGQTPWFQTLVAAISRSIQDDEGSVAVDIIDREQETMSSEDEKALIEALNRWKEDGLRMPEVFDTLSKDLGGDVHGSASRDWRYVSDGSGPLAASARQRSRHVTKNNGTKTTSNSTRVLSRAREHPCPVTREDLRAMALYLFEKGDDRAGPDTLRRRNFALWREFAARPENRKRTLDAWTSIPRLRPKHAAEIERYLKVFQKDADAAKSGMAAELESSLGKHVPRGGTRTALESAADPVHVTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNJ1</accession>
    <name>A0A2G8RNJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNJ1"/>
    <dbReference type="OrthoDB" id="3255683at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55770" checksum="A3089BA7B136C9C1" modified="2018-01-31" version="1">MIIDEPEKQDPVVAPAPQAAEDLSYAPPEDDEEVPAYPYPQEDGSAYPDEKPQPQPKAYTRPPPPPTRTPQSISSEDSYVRDPHKLVAYLIPFPKPHLKNVARSDVPDRFLVYTPPPPPLTKPAEGEKEAKKHLLRRKWQAEVREAKTSTAKAGSWKGMKSRATRGIDRAIGRTTSSGLDFLTRMGEDGKGEKKGKDKDKDKDKDKDKDKDKDKDKDEDKDKDKDKDKGEKEEDATRARAQEESPAADGAATSDGAGGADGGGEENAKPEETAGLTELVLAYPSTYRNTPEEMRKEFVESMLRTKSKAEKHTILATGLLPVALAIDTLAMVVWPFGGLFEIDSVWAYASFRGAKIARSTTKRLEASEGTEGPADESASQTTGDSSGTGEKGKKSKKGNKHKHLKLTFTPSARVQTIARYLTARCHDRDPRMFPPAGGSPTETEVLEAIGWAPSQIGGERKNYQDEQWEISELKDDLRQVMQKGAREWDKWCKAFEKNPKKALKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNS1</accession>
    <name>A0A2G8RNS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNS1"/>
    <dbReference type="OrthoDB" id="2753628at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="203" mass="22411" checksum="AC9C708DB8189100" modified="2018-01-31" version="1">MNDATQTYPLVHFAAVQGVEIASTNDQRPDVEFRPGGVMLAELVPGEFAIIITAQPCTNTIAAMTITHNYQVLSDTERLEVRWTSGSTRFLQGPTWLNLRFANRLLFTDFNRAFTQILWDVQLKIRILQDRIEEIAFGNPSNFISYCRQYLGDAYFDSFVDSDGDSADEDVPPAEGGTQGDDVTGTANGSGGAPVFSEETNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPE3</accession>
    <name>A0A2G8RPE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_14705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPE3"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL23394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="410" mass="45666" checksum="272BC4004B25F75D" modified="2018-01-31" version="1">MSSAASSSEKPFKVVVPDADIDLLQKKLALVRFPDELDGAGWDYGSPLADVKRLTEHWKSGFDWRKAEAEINTLPMFTRDIDVDGFGTLNVHYVHQPSEVKNAIPLLFVHGWPGHFLEVRKMLPLLTAGGKDHPSFHVVAPSLPGFGFSEAPKTPGFKGPQYAELLNKLMLSLGYNEYVYQGGDWGHILGAHTVFHYGNKHIKGWHTNMPMSSPPTFTQYPLLYIRSMVSLVFDKAARNKLLDMSKLFISGMGYLRQQSTRPQTLGYGLSDSPVGLLGWIYEKLVAWTDKYPWTDDEVIEWVSIYYFSRAGPAASTRIYYEMSDGGEQIGRSPGWTSVPLGVSYFPAEIMRLPKSWANTIGKLVFESEHDKGGHFAAFEVPEKLAGDLRKMYGKGGPAHGVVPGKNGYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPU1</accession>
    <name>A0A2G8RPU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_14843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RPU1"/>
    <dbReference type="OrthoDB" id="3268677at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019783">
        <property type="term" value="F:ubiquitin-like protein peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13361:SF1">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="200"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1708"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1744"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1961"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1760"/>
            <end position="1771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL23530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1986" mass="221256" checksum="D9EA3618D5A3232E" modified="2018-01-31" version="1">MSTLDLEDSPTYSPGDWIGRGKTFSYADLPSSVVKAYQDAIKLPTHLRNDLIPPASTPISDFVNIALPPPDQDLLHTKVEEWFSSDPPDSEVDALPERPLPPARLLRLLFEAAPQAWLDSRLSVLDPRYKEASRYPLYAITLWRDLAFVATAQRQWEECVAWLSNLIRDAKYASISKDLRAARGELLTLPWDAGIRMGKVTTPTSTLARLLGPRWLCDDLIELMLEDLIARQRVDRRTGGGGEVIGGIAVMVELKRAVRNKEFNQNLPFLHHIERAVKAKTCRGLWFPACVNGNHWVAFHVNFEDQVVEYADSLARSGVAPSPKAEVAAIEKWLRARFPARYKTRGPSATQNQQPDTSSCGLFAISAIRTAVLGDVALEAAPVAVARERVSWFQMLARHLVKTDSNTHMPAPERPRVRPRLADLLNPVIDKPASVPNLTQSTQDPRSEPSSELTAPRPICATPASILTPTLCPASASRPTTPPPPLDEPEVPSHTLTTSTTSAVSTGTPEPTAMIPASAQVPAEVGDYTVANPALEVEAGVSHTSDHAEWGRSTTHKDDPSVEHTMHEEEELDIPLPDVPSPETYLGFPDTFSCVPLDCEGSPHPSIPPSPSAISLASTAPQSSCPSSPPGSPMLVSSGPASPKHLASSPSSCFESLAIPDDLSMLDDVMSFTESPAPDKPPSPKASSLPKLATIFTLAGMKAATSTLKRKSEEAAAAKSGKRHKVASEGGQAGQSRSAVASREAREKAAKGEFVWSPKKLTNWQFKIWELDEDAVLGEDNLHVRCSCCGKWLKIKEAYDATRYKDHYKDCKKKHKGGLPTLKQMAGWFGWTFRRPKTAHQSQYIVQEESEPTTDLQHPCRGVDARDDERIGTYLRRTGAVGGGGRSPVVIAKERLKKTFGDLTRQQKMTILDVQISEHKWRNDFRRTRVYATNCFNYVKTPEKSCERCCALLQLGRFRRAIRKPIPKDENYIFVNHLYRDPHLGELYAKTLGLRGLLDPDAKGHKSPFVRYTLGVLENRYTGGELLAGLLESVMIQEDKQRRGVGMQNFRWPVEYDRFMHLLAIESPKTFRLVKQYLPARTERSYRQMESKEPGLPLTISERTFDLVEHHLRALEYPGMLALSCDDTKLLPSMSLYYDHAEKCQMLVGGIDGPLRVADPEKVREILEKTASKEGTKLRLWCLQVPLPKVAPIIVAALPIPNNLGARELVLLSEKIIRGLLARSIPVVSYSHDGTESERAVQRLLFERADSYREYSISSPAGPGYDLHVKVAIYDTQPIVFVQDSLHARKTFRNNLFSGARLLVLGNYVALYRRIRRAAFEEGSPLYHRDVEKLDRQDDNAAARLFSADFLEYLITHHPEDVGEIIYHFIFAEVVNIWQQRSEPLPERIRPLMRAYYFCKMWELYLQRTGYSNTQYCLSREALDITRILIESFFSLIMVHRDYCSTHAMVFPFLPWLHSTEPCEHVFGLARQVVKDFTYADFLHLEKKLRLKLWEAIKLGETSNPRARASGYNHTYLDTREIDLSALATYPTDSEIQDAAATGFSEAESLVGLLGIIPSYLHAFSSAAPAHAVAYQPAISGNTPSVSANFESHADASPDADSDCESISGDACVDEQDSDSQDAFELQRLVLEEEARVWRAGEFTDKEEQKIEALACASLSLKMDDMCRIAELKEMDEGQEQEMHAEACQHIAQALEQSSTALSLAKREALEREQRKTQAAAPPQAPRVSQLDLSHLVDLCRKNQTRQSAESVRAKASALPHSTTDTSSAEKSVQRRIIEEYYRVQRERQGRGIGTGMERQARWCEGEQEHVMSALPAGNSANAAETAGSRAKKVVVRRKDVFHQARVPMTIMDSVVNARISSFAPLKLDQYIYLFVDNKVTIGQGEYLVLHWVCLKPVAHGIFQSSTFVRSSEASKHVILQLTIALLLVLSQTSQCKFSNMSMGGASKSSAGERIHSLRNGSSFSPRHHFSAPSSRRLPSTVGPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQK4</accession>
    <name>A0A2G8RQK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13532</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQK4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQK4"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="9">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="150"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="46912" checksum="977A351F7B876AD1" modified="2018-01-31" version="1">MCVTATVNSTIATYELKSLNQLGWMAIGFGSHMANSPMVILWQTVNGTVILSQRQATGRVEPLPVTDPPRRATVALRDHTSQGVSTILAFDIPKNNDTIQSLVWAFGVTAPAADPSAFIQQHLDAGAFSLNLSKELEVASVSASGPTASSTQLGGPSIAVDPAPPQSSPVTASNLLHTDGLLVAHAALSAAGFLILLPLGTLVARWARVFTPRWFTAHWFINVVLGIPLVCVGWALGPLAVAQRGRAHVVTPHQICGVALIVLYIFQLALGTLVHLRRPKDGKGHPPRNVGHVVLGLAVFGLSIYTTISGVDRDAEESGASQRVVVAICIGWAAVFAGTYSIGLLFLRRQLAQERLGWNVPESVPVPLPVMVAGTRASSELVAARRRATTVVNRLADDGTHDMFSPPAWVSSLEAGGEAAGEEQTRTEMRQVQAVPVSLSAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRI0</accession>
    <name>A0A2G8RRI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRI0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRI0"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="37305" checksum="914127C4A9A247F1" modified="2018-01-31" version="1">MSVKTVKLGGTASNITVGKVAHGLMTVVGHSEDAMLDDEAVFAAIKAGVDLMPPGVKMFLNSAEFYGPGFSTGNLEVLSRFYEKYPDYADKTFLSVKGATKPGTIIFYALLFLDTVIAALRGTKRVDLFEMARVDPKVPLEEMIQTLVQLKNEGKCDHIGMSECRAETLRKANEIHRIAAVEIEVSLWSYEEEETKKVIATSEELGIPVIAYSGLLTGTINNPSDLAEKDFRRTFDRFQEETMKHNQTILEEIKVIATKKQISLPQLALAWVASRGPHVIPLPGSSKPERVVENCLSCNIELTQEEQDAITDILARNEVQGERYVGGPIKQHLHLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS18</accession>
    <name>A0A2G8RS18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_14046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS18"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS18"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL24293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="410" mass="43831" checksum="EA7D7AAD051AFED5" modified="2018-01-31" version="1">MAPPEIFNLSQQSPITCHAFNADRSQVAVSLNSNEVRIYARQGNDWSHIDTLSEHDKPITSIDWAPNSNRIVTSAQDRNAYVWQQSPDPQTGHMVWKPTLVLLRINRAATFVRWSPNEDKFAVASGARAIAICSFDPEGDWWVSRLLKKPIRSTVLSVDWHPNNVLLAAGSADIKARVFSAYIKDVDKRPSASVWGEKLPFNTICGEYASPSGGWVHSVAFSPSGDVLAFAGHDSSINIVYPGGPAVYSVKLSILPLVTLTWTTEESIVAAGHDCQPLVFAGNQGSWELVGSLDEPQSSKSAGSTRSGLGGPSPVGRLNSAAFNTFRNAAERGISNAPGSPTAASSGESELFTVHQNTITSVRPYSGVPGQIAQVSTSGVDGKLVVWDVNAVTPISAAGLAGKLGKMQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSI8</accession>
    <name>A0A2G8RSI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSI8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSI8"/>
    <dbReference type="OrthoDB" id="2758274at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="312" mass="33435" checksum="01BDE37644A6188F" modified="2018-01-31" version="1">MSPVKCLECGLIWPSKNKAGGHKPGATAHKLAYACITCSVTFTKCKDLHSHEAAARHKPPQDLGPVMAAAQAAAERGSRAACTALASASGPSHAPAPSWEDDADADSDAGGYSCPVCYMEFETQDILTDHVSSTLPCAACMSCLDPFQTLEDHYWESDNHPKCRPCALGFENQAAWTAHQATCAIAPLRKSNVNNSPSKSAGAGRPWQVRVRACGIAIAGRGRLRPSSRRREYHIKMVRWGMLWEVEGVEGGGVLREVQICTQPEVQREEGACLQLAGQEDSGQVQHVGGYDSIDNIASMKKTSGRQSCGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSK7</accession>
    <name>A0A2G8RSK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSK7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSK7"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="157" mass="17195" checksum="4DBE7A743A474392" modified="2018-01-31" version="1">MAHSTCPHVSVGGHTARHPHGGLPQAITLELLRRLPRSNGQRHGAEHVVRHGPAPRLLRDAVSPMTAHASNALFAYLYWPGTNTSAVWFAIFDLYGAGTWRSDFNASYTRDAMYSIQYHGAIPASVAEKDGVAFVQGMKGGGQPETRFNEHGECRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT41</accession>
    <name>A0A2G8RT41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_12569</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT41"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT41"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL24685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="536" mass="60813" checksum="6BB4D59FFA6BF3AF" modified="2018-01-31" version="1">MDLVSLVTSHLTPQILLVVFLCTLVLAYLRSRVEWSARSRGSPLPPGPRPLPFVGNMFNWPKSDQPAGLRDLSIKYGDVLYLNVLGKHMIVLGSSSAILELLDKRSANTSSREQDNVLGSLLALDFNFSGMAYGTWWRRHRRAFWQEFHPAAVSAYLPAQRQGARRFLNKLLTSPSKLREHVRFTFTAAILKVLFDVDVADDGDELVEVVEAAMEWHDEVYVVGAGHSILRVFPILRYIPPWFPGATIQRRAAYWRSTVIRLKEEPFRRFKAGSFTRTMGNSGGCAVGRMISRMVRDTEKASAKEEEEIIRNVATVAIEDANAKTDLSQMFSTVQSVFIAMYLHPDVQRRAQAELDAVVGPNRLPDFRDRDRLVYVNALIREALWWQNVLPFAIPHCTVEDDEFREYFVPAGTNIFPNVWACMHDPEVYEDPDVFRPERFIRDGRLDFSTAPDPTKLIFGFGRRICPGRYFAENGLFINIASALHVFDITPPVDEKGRVISIVPQMIGGLLRYVKEVVIPQTVGAPLNLDLHARRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTS0</accession>
    <name>A0A2G8RTS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTS0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="16516" checksum="2B60829A62D41B6F" modified="2018-01-31" version="1">MRRATASDSSSSVRMPTSDGCVSTTSAAADAATPAPSPVWRCTPIAACASATASFVPSPQKSTVSPFAESSLMYACLSTGRQLARTRSAGIPRTVAGDETAAGWSPLRMETRMLRVARAWMTDSASGRRVSESPKTATRRMPWMTQNVVRPWANSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUJ1</accession>
    <name>A0A2G8RUJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUJ1"/>
    <dbReference type="OrthoDB" id="2507488at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="631" mass="65893" checksum="D9BF163C77D14C41" modified="2018-01-31" version="1">MYRPPSPTFDVPELPAPLRRVKPLPKRRRTSDPAPHDRDDEGLGLGSPAGATTPGHSHDDGQEHSGSAPGTPDPTLAAQAVLEAYYMPVLGGVPDLFKHTHTHAATPDGEDSRTSTPISIDLSTALAAGLGYGTLGGFGGAAGSTASGGGSGGGAGGDGQEDEDGEGGDYVDHLQQPGNTKKRKVPANMSGSAHGHDAGSGGSGAEDDGADRDQDRDRERDRDTTRRERDADAVGGGLRGGGLGGGGGGAGAQLQLALAGKKGRLSRATLAGLQHKEVLRSRKRQLAAVIATLSHGDTLALDHALSANHIFVQANTRVRLSRRRAARFTRALKAYASAHFPGEGEGEGEVKENGVPSSDFTFVFHCATSDRLVATREEVADLHGRFEAELARQAAKAAEAAKQAAASLSGPLAKRTNGTKQAARATTGKGPDPKNALEQSLLGNKGSKGGKKKKRSALANASNPHHLRNYVPSRLPHSGPPNAQQAVQNAQNLLTPLPLRFLSAEIPPRRRKKSEASVTPVATTLTNPADEWICPFCEYQLFYGDDQSYNRAVRNRKKILRRRRRARERAAAAASGVAPAAGADKAQEDDVQAGFESPAPLPMAKVTPPAAGKQAKWKEGDRGGHGVAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUT3</accession>
    <name>A0A2G8RUT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUT3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUT3"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="31468" checksum="9807489F5FE9A2C8" modified="2018-01-31" version="1">MSNAGTTPAPPQLPACYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLASGTQPWADFAAFETAFKAHFCAADDKEAAIAELVKLCKGQHKIGTVQDYTVKFNAIAARTSFSAEDKREQYRTGLPYKIKDILATSGHDTSSITKIQAVALTMDQNLLVREEERPKQFSGGWRKKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSSETTDLAALRAELKEIKERLNAVSVNETKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUW4</accession>
    <name>A0A2G8RUW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUW4"/>
    <dbReference type="OrthoDB" id="2766169at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="747" mass="80632" checksum="4A6A64F23DD53636" modified="2018-01-31" version="1">MATSQYVGPKYGEKGAQMRIYPQRHQAPKALQRAMGNDKMCMEMCPSPGLHLDKLGDRADPLPPERKKMYQKKKARVQAARAKAIRSLERGIKSPRKTVAKRKPLPIENTTPPPEQPPPLMTVFPSAPPPPALSASQNETSIDSRAQSPILPRFTFSYSVPSVTLDSCHPTGTASTGPELVYKPPQTAKNDLTENALNATSFEFYAGPQSRHASDLALSHSPSPNSTPSLESDRGTPSTVESPRSSGTWIDGPTPTPQSPSTPEQLDCRLSVPQRDVDSEELFNEVYQSFFIPRSSWNRQSPTLELEHGHMNPQSVIPETPHKARNTVQHIPDRLDRPTPPQPATMSHPDLRTRDLMPTTTTTWTSTPQGSHSQPRHLHVPATTPSGMVHDHQRRGPAGKGAAGATGTPGVHRLERGTFGRQHAPPPYPSHFTRVAAGHTRLNHSLATPESPVAAQSAGCGTTPSIAGAVARQAQVRHHDGSAILDHAPHNNPHHLSMRTSPSHVHSVHANSVPLACTTPVPPVNSITQHQFGAPNTTRTQRSQPMRTSKSAYSELAHALVDPHSIAPLVEQAGIGERVGHGHLYSAQVGSGAIGSSRTSAPEPLAHWQIDPPIASHPILDHPLIGPGTNVMVAPSTSRAQATHDDDMARTLGGCFEECEPFSTNIMACLLGTHFANRQRSDETYLEASWAGSQSEVTQQLLTTPTCQEAQCRIHHPYPPSTGPSSTSGFTSAPMQGASDWRTLSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV41</accession>
    <name>A0A2G8RV41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13276</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV41"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV41"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="435" mass="48753" checksum="460AE32B8FDC9D60" modified="2018-01-31" version="1">MSKAPRPFKLAVPDADLDVLHQKLELARFPDELEGAGWEYGTPLADMKRLTEHWKNGFNWRKTEAEINKLPMFTRDIEVEGFGTLNVHFVHQVSDVRNAIPLLFVHGWLGSFLEVRKILPMLTAGGEDHPSFHVVAPSLPGFAFSEAPHKPGFRGPQYAELLNKLMLSLGYDEYVYQGGDWGHIIGKHAAFQYAHKHIKAWHTNMPWSIRPTFMEFPLIYIRTFLAFFFDKAFKELIASAPLQMARKTGYLKVQSTRPQTLGYSLADSPVGLLGWMYEKFVAGSDNYPWTEDEGTSMSLPPSPFPPSPPLSPPLRLSPSPSFLLEWISIYYFSRAGPTASTRIYYEMSGGGQWAIGRSPGWTTIPLGVSYFPREIPFPRIWVGTIGNVVVESEHDKGGHFPAFEVPEKLVADVRAMFGRGGPAHGVVPGKDGYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVH5</accession>
    <name>A0A2G8RVH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVH5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013755410" evidence="1">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="17005" checksum="5A7DBD45935B33E7" modified="2018-01-31" version="1">MDSTQFLSRIVIPAAALIVVSTDNVNSPKDTVCASEPLDFASALPSLATVATGPPKDTQRSRSQARRRSAAPLTRLGLVGIYFTVAAETMWCTLFRTFPSLLSLRASADSVSVALDHAAELVEGWSAPLFFKYSWMWGVLDVKPVIDRLRYRAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVQ6</accession>
    <name>A0A2G8RVQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_11354</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVQ6"/>
    <dbReference type="OrthoDB" id="2505288at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="10">
        <location>
            <begin position="420"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="9">
        <location>
            <begin position="720"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL25606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="89473" checksum="0F09F5C3018F7F98" modified="2018-01-31" version="1">MSNAGTTPAPPQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLASGTQPWADFAAFEAAFKAHFCAADDKEAAIAELIKLCKGQHKIGTVQDYTVKFNAIPARTSFRAEEQEAFDELKRRFTESPVLSISVSGGGGGKWHPVAFHSESMSDAECNYEIYDKEMLAIIRALQAWRHYLEGLPSVFKIQSDHKNLEYWKTAQNLTRRQARWALYLSWFEFVILHKPGTSNGRADALSRRPDHQTDDADDNLDHVLLQPDRFRVLAAKRGHMSVVPEKALLRRIRECGEREQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGRVYVPKDDALRAEIWPGMVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNALQLIADRHGKIIHLIPCTEEIDAEGTADNFIREWFRLHGLPRKIISDRRPQFSSKLFHAVLKGLGIESAMSTAYHPQTDGQSERWNQEIEAYLRMYCSRHRDDWVKWLPIAEFAFNSHVHSATGYSPFYLMYGFEPQFHIPMLSTAVPSVDERREELRQAREDATSALTLAAERMKEYYDRYVRDAPEFEDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEIEGEEEYEVEEVLESRRYGRWKKLQYLVHWMGWGPEHDSWEDATDLANAPKVVQKFHSTHPDAPSPLNKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVR8</accession>
    <name>A0A2G8RVR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVR8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVR8"/>
    <dbReference type="OrthoDB" id="2750871at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="1">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="654" mass="73844" checksum="9AB88BD960FB55F9" modified="2018-01-31" version="1">MPIVSDLPWFGEGPQRPAATSGSVNAPAAAYSNDRMIVVVDLEGVHELPFTFCACPNAPRDDLQLIDLGYYPASTQLPKTVFTKRVLDDFLLSNKECKTSARNYYNKLRRTTNPAFPHMVPDRYKELLRVSRQWRNLQMRINAGFGHRSDAIGPGDLAIQCPACPQPETNLPDGWENDEHGWKYMRSIVLDGNFSAQHRKMRNPEDDVPLADGHAFMVTDAPYKEHLKMAAEFHEKATCNDHRAILTAALDRANLEATGIDFQQGERQHNMDYILHWIFIYLHGLTRVLILYDIMCTLLTQKWRRACKEWGPAVAAFDELIEGSDPVKCEEWKQEADAADEARVSDPAAMDIYDVATKPLPTRKEVQIMLSQQELIEYGGAEQLGVADWIGNGLHIKETKLAVAYTARRVKATSGTDTRLSLVQQWQRLASAIAAFHKAGRKHMPGYLPGDGGGLEEDPTVFGAEWDEEVVSGDQANEPDFAANRPEDLPIGLPSTFGIEFLAQTGLLDLAKKERHLREGQLNDALQGIRTGIGYKSLLYRAKVRNASSYRAKLRSFDDVHIADEGVWKHVQVYQQARRAMERLFDPDDVDDVQALVTFQTRYKDIRREDLRVSTAVIESFTPGVRNEHSAWFWNISDTSSGEEAQWIQDCKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWW5</accession>
    <name>A0A2G8RWW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11561</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWW5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWW5"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="491"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="654"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="804"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="816"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="885" mass="95054" checksum="CCBEBF481D07DB6A" modified="2018-01-31" version="1">MLFFQPVHVQGFAHPTSFPGIYSEDDYVNDMTHRAAHDYALAHARVQAIERQHRQYRHYPHNHQYQSYPAALYSGRFAPASLDNFGPASARPPFFSPVRRVFANPFEELELAYTVWQEEEPQRSLNHRREAIARQRELAREREAQRRRALAEAAAREQQARVAHAARIQLRQAHDKQVSLALLGQLGFAVVPAQSAPVAPQVNKQQVCNLRQSNGFGGLTRIPLQPSLLFSRPGASVAPVPAPFPLPVDRKGKGKAIATPAEIPGPVSRTVPVSPKVPTLKEELEACLRSETDPDVQESLVLLYSDLFDVREPAQPVAGPSGHKHTHKHVSFAVPVPSASAFAFASASASASASASASASSSPLPAKAEEKPVPVPAPADKPAADEPKPKPEEHGEGARLHRTPALPPAVAAKLLEFYRARRARRLSLAHITDVEDALRQLEGAFEFPAELDFVDRPRSPSPSPSLSSDEHSDAESAELAYTANNTPVHAYEHALNDLLTRLDAVESNGDVEIRGRRREVVKEVERALEAMERRIEESRERSRERERARVRRGSVSSQVSNASVTVTPYNVHSSGNVDEVEVAVVGEETPIEAQATKNAVELPAEESEVASDAQDAPALAEDVVLQAEVVEHVATEESPETNVDTAEPELPQLAVGIPDSGADTNQLPSSDQLMHSDPSSPIDDDVEDLAHPGDDPAPDLSTSALDKAAAPLHETSPRAIVEQEHGDGPCPVVQPEAVVATSPESGASVPTPHGAEASEPISPVESTATDATLVSGAEPISNALPEAEEATVFIADTASPSECELAKDLGRNPPRSESGSASSSGEAAIPILLASTPLADGQPQHTQRRVSRSAGDDEVEIIGEDELQAARNESDWSDVGSESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX72</accession>
    <name>A0A2G8RX72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_11865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX72"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX72"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004933">
        <property type="term" value="F:mating-type a-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001546">
        <property type="entry name" value="GPCR_Pheromne_A_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00900">
        <property type="entry name" value="PHEROMONEAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL26111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="442" mass="49544" checksum="58967DFAE2940671" modified="2018-01-31" version="1">MSPVPQAVASFLAAALVLIPLPSHWRARNVPTISLAIWLFVLNVAHGVNVIVWWDNLQLKLLIWCDIVSKLVIGANMALPAACFCLAMRLEGVAAVRHAKTTYPDKRRRMVVDVAICVGTPCIYMALHYVVQGHRFDIIEDFGCQPESYVSLPEFFLVWFVPILSCLGTFAFGGMAFMHFFRRRATFARHLAASNSGLTPSRYFRLMTMSLALIIWDLVVFALTLCFNYRNGLRPWTSWADVHSNWLRVNRFPIVAIPSSDKNWLYFIWWTIPATAYMFFAFFAFGHDTVVQMVACIQWTRRRVLRQNFNRKTVTPLSSLDKPSLSSPHPHGFALMDSKDDMLASPLSGPLSPSSVDYSRFSWPDTPSTTVSIPTCPSTHALDGKAADAQSMTTSMSNDPSPPYMPPSPSTSPVLIAPPQATLRHGERDMEVIIHAYTAQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXU5</accession>
    <name>A0A2G8RXU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXU5"/>
    <dbReference type="OrthoDB" id="3069822at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="104" mass="11905" checksum="2CC7695B13365C6F" modified="2018-01-31" version="1">MPQRGNLCHEDSRTTSLNVSRSPTPFAGSSVRIVEVDSGEDTDGEEHAAKRRWRTLKERIRPHLRERIGAVVEDEDMEETVSLGLSSEDEQDDDIEEFFDRQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXW8</accession>
    <name>A0A2G8RXW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXW8"/>
    <dbReference type="OrthoDB" id="3238099at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="61683" checksum="95C0567764A8D85F" modified="2018-01-31" version="1">MPSLPPELWSLVINLLRHRDQIKCLSVSKMHHDIAFSSVFSHVRVTFGLWIWRPMMSDRARVHPSSNEQECMTRRNYTTLDVLRAISSRPDLAEVITRFTVYACDLEDSGNSTEQLENLRAALEVLPNLQVFHWYGQRPEPSSAVFNALEAQSATTLTEIRLPMLEKYYMRALPPQLYHFPNLRSLSMIKQASWNGPGHNIYEIVTTLVDVRTEILAHLSISGDVRQWRRESFSGLRELELIFTMVFGLGGFADVLRDCPSLTSLTLLPVDIADPADIFPAFGAHPHALPGLTAFKYLKQAEAEPPTTPEHVAALCEFLKNKRHLRQLDVALQAEDREDDPLFELLRELPALEVLGFDFTRADWTPSDDIAFFERVIPARLSALRVGQLVLVHEPDLCASYRAEWLKLFKSRTSLRYLHIFESFIEPPETETALRLRQLPIEELPASLELYGYGLYMHPVVREPLDAGSNSDAPRATFGPCWPLEKVVFRTKEDFECPDWEWLLRWHDYPGLDMLRPSVLPNGPPLMLNPDIPLLHGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXZ3</accession>
    <name>A0A2G8RXZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXZ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXZ3"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="265" mass="30488" checksum="112F5D1D16912BB6" modified="2018-01-31" version="1">MWLLSTDRAELHFFATPQDVPDGYAILSHVWDMDGPEQSFQDTELLAAKYSGPTDSPRKHASRKVRECCKLAQKHGFSWLWIDTWCIDKRSSAELSEAINSMFRYYQLARICYVYLFDMEVPPIPSPAMESAFVTRHPSERNITSDPSLTIMFSNSKWHKRGWTLQELLASKFVAFFSRDWQLLGSKSDLSSLLEAITRIPQPVLTLQTPLSSVSISGRMQWAAERKTTRPEDEAYCLLGIFDITMPLLYGEGGRRRSCGYRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYZ4</accession>
    <name>A0A2G8RYZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000038">
        <property type="protein sequence ID" value="PIL26741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYZ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYZ4"/>
    <dbReference type="OrthoDB" id="5314275at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="46145" checksum="C1E18E7B4A4EE9C3" modified="2018-01-31" version="1">MIVENSASRDSKRNQNGFPVVCHPDTSSRDDKLVAGPSNEPPPPTYEEAVSIMEASSSAHATMSTSSGGFAPSRSSSNYGTATSQSQEKHAPQADTSTLSPYANPAVTGYGVSAQSLSSGPETSLGRHSSVASYYAPSTSSGKSRPDSGFASSFTTSSSSSGDSGASLSIARSSSTSTTHTSSSCASNPSQPDSPSDRGAPSPAHPQSQPSTSTRAASFARAPENDLPYGAFPPATLHAYSDDLEADGFPKDPPTCACAPAPHPFVTHDVSEEDWASFLDDVRGAGGLSPVNGLIAGAAPIAVRAGIIGGIIAGHALRAHMKSKRKSPVADKFFHPRCMDVVLAQGTIPYTGPAKAVPPDMAWRARENGTGKHVKAYEDTSDDENGYSSREIPGMAAVASAGRQLGRLDSTVKGRGTCSRIALSRDLKASAGERWRLVVSYNPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ74</accession>
    <name>A0A2G8RZ74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000044">
        <property type="protein sequence ID" value="PIL26618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ74"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ74"/>
    <dbReference type="OrthoDB" id="2723743at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="98" mass="11289" checksum="ACAFDD66EF73AACD" modified="2018-01-31" version="1">MSSAFRRVCRELDKENIETRDTLIGDQGSGGNGPRIHQDTAPPREADTRAPTGLWRNCYDSVWLVGLKEDQVRRLEMIDKDFDLRLPKDMPSDKEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZB1</accession>
    <name>A0A2G8RZB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZB1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZB1"/>
    <dbReference type="OrthoDB" id="2802485at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="93" mass="9803" checksum="92931AF4948DABA7" modified="2018-01-31" version="1">MDDSKRPVAAVANPVLDNMASSKEQGDTAHVEEAGPEDCPDGGLSAWLVVLGAFCGLCATVGLVNAWGNGTNLQTFQAYYQEVELSHRSSSDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZG6</accession>
    <name>A0A2G8RZG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZG6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZG6"/>
    <dbReference type="OrthoDB" id="3268787at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="292" mass="33410" checksum="3115971632AD0F60" modified="2018-01-31" version="1">MTIVAYSSDSDIKIPRWDPKTPIAVSPTIRIANKYLVDGLHKYLVQKVQDDWPLTLEDWDRREAEIEVMGYAEYTSGALPSSRKPLAQAVPEPASAIHFALEFGCPQILPAAFYQLSRTDVTDDWADPVSYSSNWMTPARWSLLEAPDLLRHLRGGKRLLQYTASVPRDVTFTAVLCEACLPWWEDAAVHEEVRWEIEDGRDAEEYPCYALLVRIFAAVFRETTPGVRDPLKALKECVDYEKIPEIARGSSSTKRLCSGCDWAFREWVPQARQELWRKLPEYFDVEVPSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S051</accession>
    <name>A0A2G8S051_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10294</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S051"/>
    <dbReference type="STRING" id="1077348.A0A2G8S051"/>
    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF1">
        <property type="entry name" value="FAS-ASSOCIATED FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="139"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="284" mass="32057" checksum="734D008419289502" modified="2018-01-31" version="1">MTILSRHQGPSIPSTSGPTAAQTLVTHLNESLLPRVTPFLNNLRAEAAERERERALRAEQDLAFEAARRKDTDRILQKRAADAAVAEQKRLAAEAEARAADEERKAAEARKLWDVRRMEWRRWLRRGLVLREPRPGENGRGKTMRVGVRLPDGRRLVRFFGENDPLTALYAYVDSLLIPPEFVQDADPVSPPEGGKAGEEGVVLDIQASRRSSEKWWGFKLVLAYPRREIPWEAEKKIGEVEVLKGGGQVVVEFIADEDVKSRAKSRSSLEQDGDDDEYHTESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S093</accession>
    <name>A0A2G8S093_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S093"/>
    <dbReference type="STRING" id="1077348.A0A2G8S093"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="3">
        <location>
            <begin position="151"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="621" mass="69059" checksum="11BBA74F42E16ECE" modified="2018-01-31" version="1">MAAENGYYSNAVHQLRSKQSVVLPTVEPSPGTSLQARQAPHVTPPATHIPLDEEFYVYDTYTGRNRPNVELLREHFFHEGRLSHDQAMFILDQATDLMTREPNLVFEIGGSFEENNYLFLGDYVDRGCFGIECLLYLYALKLYYPNRLYLLRGNHECRHLTEYFTFKRECLHKYSIEVYDACIKSFQALPITGLVDGRFFCVHGGISPELETLRDLERINRFEEPASKGLLCDLLWADPIPNFGHEQDPTYERPQGLPPGVPFVDNHTRGCSYYFTYEAACKFLERNQLLGIFRGHEAQDAGYTMHRKTPTKKFPSVITIFSAPNYLDVYHNRGAVIKYKNKNITIRQYNATSHPYWLPNFMDAFTWSLPFVGAKITEMLLAILSVCSDQELESVSSEDDDAERARGLADDDYSSGEDDTRTIPDGPASLTDLADRREVIKNKILAVGRMQRVFQLLREEAENATELLPTPGAVAAGITAPASGWAGGFSLAGAADALGVHGQQVRKMIRSFSDARASDLANERMPAAFDYAAPSALPLVPVPSMRIPGFELAEDELDAQGAGGSGVGGGGGRRGMEELIKKALEEEGLGDGGMVERLANKIAGGRKAGRPKALKRYETAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0I1</accession>
    <name>A0A2G8S0I1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4100 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0I1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0I1"/>
    <dbReference type="OrthoDB" id="2748586at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025165">
        <property type="entry name" value="DUF4100"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13352">
        <property type="entry name" value="DUF4100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4100" evidence="2">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="346" mass="37667" checksum="62D8F522B7D189F9" modified="2018-01-31" version="1">MFDSTSVPKNAKASAPGAHAVEKPRPASKTSQISKDVDPGVVLDKILDTPVTLPIRDIVGSSKEVSACLQDAIKVKKVDLGQPITSNLVTKNKHDSLIHIEMKYKDTPIDFIVDMGSELNIISRRVYDMFEGLVINPAEAVTMRDANGGSSKLLGLVQEIPLKIGPIYTPVDAYVSTSPAFTGVLGRPWQREHHIGIEEREEGTFLTFPNDDGVSRSCLRVPEAYTRPMGPGPPLLSPESEVFGIVAEWSADKAEVHSGQDIDIDPSPPTVNNSVGSSQSRDTTIQSSDEQMDIDSEENSANMKDNRDNASQAKDLLCLQRTSSFSSSNTTDSAEERMDLFLQQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0M6</accession>
    <name>A0A2G8S0M6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0M6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0M6"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553545" evidence="2">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="13346" checksum="55D5E3018872233A" modified="2018-01-31" version="1">MRFSVAAALVALSAATSGYAKVMMSKSGGDATYYTPGLGSCGFNNVDTDYIVAVDHATITSFPGAGANPNANPMCGRKMRVTYGTKSITVTVADTCPGCAVGSLDLTPTAFQQFAALGVGRLHGIKWSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0U8</accession>
    <name>A0A2G8S0U8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_10511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0U8"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL27364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33824" checksum="24D81979FF22B27A" modified="2018-01-31" version="1">MFTPVFSIKHLRNMLTIFYELVSALSARVDDGPRDMDILHWMSRAALELIGQAGVGYSFDRLVEDEDGNPFAEAAKTYLPLSLTPEMVTMRNIIVPFKGIGPQWLRRWVIENFPHQGAQDLRKVVDTLHLTATRIVNEKKAELENGQRRDTKDIISILSACIRSSEGFLCAGGTERLTVQQNMKADEDERLPDDQGVVIRRDGSDIGYPTAPLCYREAHQDAVLPISKPIRSMDGKMIDSVFVPKGTQILASTAACNRRGEDADEWKPERWLKGVPSAVEAAHIPGIYFHMMTFLGGGHSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S187</accession>
    <name>A0A2G8S187_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S187"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="182" mass="19907" checksum="EA5050FAF645EFA8" modified="2018-01-31" version="1">MYDAWSVFRKAALSPRLIATHLSNIQHPEPIRAVVEARRNQRAWVNLKPPITQSSFQLSEKGQDTSGGLQSPDPSGGSSSIRKRRSPRTCTPWRVRPGRAHPNRSVNANAAPSRTHDEAQALRRVRTGSLFCPEDLDPKLGAEVSDGPHAGRGRGLPSPHTPTVLTLTSQRQGRAQASRFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1M1</accession>
    <name>A0A2G8S1M1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_10814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1M1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1M1"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL27662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="347" mass="38261" checksum="0824A60927226FB0" modified="2018-01-31" version="1">MYDDAILVPCGHQYHIDCLLSLVETSLQTISSFPPRCCRQNIPQDIFDRYLTPTQRTAFASRQAEHDTPKRVYCSNPRCSHFLGPRDKGIPVRILICPSADCGTRTCARCKAHVDPGLPAHKHECSHDPGHRATLRLGSQLGWVRCPACEELIERHGGCAHMTCVCGAQFCYRCRAVWRTCHCVDWGDGVGADAHEARLFEPLEDVGNLDAQLALWTPAALEQNSGANSAGRTEAEAEAEAPGVVPRPTRTQTQTRRRRSCTLPPNDALRAFSTGPTPSPRSSTSPVATERSKSISPASRARSMRSQSFQTVSEVGVCFPFFVDPAIIARGVRAQEARRRRPRALSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2A2</accession>
    <name>A0A2G8S2A2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10841</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2A2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2A2"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="244"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="464" mass="51196" checksum="FDD9A8CC1DC6BE42" modified="2018-01-31" version="1">MSSAQTNPKTPPALAPATSGEAKARGANRSTKVAGKLKVLPEHAEPVLEKGKVQPPPAPPTSKPDETGEGSGTLADSEDDEADEEEEPDDAEVYNQIDLIPAGTARRDALRLTKKKAKSLPRVTAYATASSYRFPELMKFFNARRGSYHTNPRIIVDVIYTPYVYEPPSAQPSAQSGTHAHVHFQTASSHHQSRTGDLLGVPELAPGGSGTDMQGQSGAEPSAGTDGKSRKRSKFSETPTEAEIFIFEYGTVVIWGMTEAQEKRFLSSLKRFEVERLAPQDVEMEDLNFYYASYSRIYNDVITLRKGSSYMTKLSLSHALAQSVKISLFENLISATIEDTKDIPEIISATGKIDMNHKEIMRKIGELFLLRTNINSVGSVLDSPEVFWTYPDLQPLYDAARSYLEIPQRIDLLNSRVEVLQDMLQLLKDTVTSRHAERLEQIVIALIAVEIVLGIITILVDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2I7</accession>
    <name>A0A2G8S2I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000031">
        <property type="protein sequence ID" value="PIL27971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2I7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2I7"/>
    <dbReference type="OrthoDB" id="2736708at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33266:SF1">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="972" mass="107950" checksum="0B6B6591A4BC163F" modified="2018-01-31" version="1">MATQSSKRSGSALDSIDPRSPKRPELVEDTSVSQQVETVSLEFLPDSHLPPRQELERLNRIIHHEIQKSVKEIRRNIVPLILYILDIHCDFLDPQPRWLKDVQELHAGELVSMAQEAYNRRDYSRLMLLKGFQRPQQAVAELSSMPPISLQAIVGGWNTPFIGTAHMTLARNIREMYQKVHRESTDRKYMTHASMVQSSGSGKSRLIDMVSETIFTIPFNVRDPGARDAASRSWPPADDGIRSLLVDLTKGSQEASLHARYLYFFQAVFEETRKEVEQHAGNRAKAWHEHLEENNGEKRNALYTRVADSEAIHHALDLDSDFGDWEQYSKILQKAKDALNLLLSAVCPNATPCPGHLAKSTTTTVEDIHILIYFDEAHVLATRRVPKSSNSKTALDVLFTVLDSFREHGVFTVFISTRLHPECATPPGSVGPSARRRVVASALHAPITETPFDCFGARPIVPSCLRAEDVCDVAFMACFGRPMWRSLLLPFCDEVLAKATVTASATQTPSPGLSASEEDRDSRCGGLIDWARSKLLCETDIHAPREVYTLAAQTAVLDVRVMLPYEPGSSRAEAYQMELVERHMRTVYSVPQHRNYARSGYSSEPILAEAAARQLNHWRALDVEKTTAGGDEVEPAVRILAQDVDGGLLDRDRGEIGEAVGRLLLVLARDRAAVKAFPQIKDKDEDRIFSRAVPVNEFIEALFPPAVAQRVLDGRPDNLAPENENEDEGEGEESRPGTLREAFKDAVLNFTHFARWEGADGAAIVPSGCAAVGCFVRSMAVMCGKNAAPRVDAFIPVLFDVGAPLAPEHMTGILVQFKRRETKGAARVAYVVHEKDVGLFSSTPAVYGRQVPLPYITLVMELDLGVGEVSVSDPVHIGQSPERASKRLRLPEDQDGLEHPRYSIAAYGCSHSVYGVIKECDEDVYKSILCAGGALKEHPRQDEASLDLVRRQKPAFSTEDVSWDWIAKEDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2P4</accession>
    <name>A0A2G8S2P4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2P4"/>
    <dbReference type="OrthoDB" id="2986010at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="90" mass="10618" checksum="F2D57E47409D43DC" modified="2018-01-31" version="1">MMGFLEWVYRKFVWRPDGEYDTYRIYYFERSKFSKQAIILGTFYNVHGASDTGLMLLSGLGWVEMIENVVKLKVFYEEDNEGQGQPDKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2Y9</accession>
    <name>A0A2G8S2Y9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2Y9"/>
    <dbReference type="OrthoDB" id="2758564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59650" checksum="A770AC741678C6A1" modified="2018-01-31" version="1">MFLRGLVDISTISDDDATSSTCSDSKESGTGIDIQAAENEVGLHSQRKRITLTEDDAKRVGEQRFRVFVEISSQHVADIGNLRKYYSEYIRGAGYLLDLDNGSNTTFASLIEYRKKSGFADASHGPPCSVHGPLSIARDERAKIFDHAYVHRDSFFDPEDPTTRGLVKFGDESGAAVLMHDQELRLSIPCFDRVENRWNCGRLLLDYKPGVACAATKGIYSRRVSGVLALGPMRHQSAFDNAVDRHSEVPSFLEALKPCLPPLPEGGTVVYLAIRPMALYKNTETGYRLLERNAEHWMALNGWPCELQADWSPPIYLVPEALGGERHWKVRLLSMTFQHYDVDTQKCRDLDDLDARTITFGDGGLVVHLDCGTSVSFVPPALVRHIRTKLWPTAKNKEIDATQQDSPCDLHSDSKPQLAFYVPDNECMSISYTFADGRGGKVQATGPSSHFFGEPNPFRANRSRTKDGEGMVFVGPPEVIGAGDSEAIFGLNFFQSMYVALHNPDDGAAYVRLAPQWDAQRHLFSPVKPQSDDDGPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3C7</accession>
    <name>A0A2G8S3C7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_09673</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3C7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3C7"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="142"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="478"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="556"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL28261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="620" mass="67902" checksum="995BF88E59E64BBF" modified="2018-01-31" version="1">MANGIPGTPEIKLCYVTPEKIANSKKFKTALDKLFRVKKLARFVIDEAHCVSDHGHDFRPDYQKLNVLRQLYPKVPILALSATCPPAVLKDVLDTLRMPGLTRSASAAEPKKTVLFNTPLYRKNLHYAVHPKPAAANDSIAAMRDYILVHHKNDTGIVYCLTKKDCESVAKMLNEMSAGAIKTGVYHADVGDARKEALHKQWREGRVKVVCATIAFGLGIDKGDVRFVIHHSLSKSLDGFYQESGRAGRDGKDADCILYYRPQDGMRISSLACDERHGQEKALAMMAFASDLVECRKIQFAKYFNKSSKLSLKSWEIGQEDARTPCGHCDNCTRPADTLERAGVRGRVAAWQVLRVAEDTRREVTLTQLCDLARGLGSSAAASVGKGKGRAKEKLTVDLERVAGGKVELSKEHTEALCVRLLVEGYFAFSFQQTAYSVNVYLQPSATAGRFTRFTKDEIEQGSGPAFDCVFLKKPGRKGVSGSGAAAKVAEKTKATRAGASRTAAAGSSNGVRGKRKRENENETSFALGAEDSEESEDDGDDDGDDMRDFVVSDSDPIEEDEDEEWHTSLRGDKGKGRASIAEPQAKRPRKSGSSSGRSKPVSRTGRTVRDQEVIDISSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3S6</accession>
    <name>A0A2G8S3S6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_08460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3S6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3S6"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013802474" evidence="3">
        <location>
            <begin position="22"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="87"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL28426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="411" mass="43133" checksum="A0187E7EDC96AC1E" modified="2018-01-31" version="1">MARFSALLALCVAITTTAVSASPIVVRDSPISLPFARRFKFSGASKIIEQDRARARVLKNVAHGKGADWGLKLKRADVLVTNGETSYTLDVGVGTPPTNYTLLIDTGSANTVVGTGRPYVKTSSSHDTGNSVSVSYGSGGFSGEEYTDTVTLSPELVISNQGIAVATSSVGFDGLDGILGIGPTELTGGTVSDGSLVPTVLDNAYAQGLVDQDVIGISFAPASSADPSGLLTFGGVDESRTAGPINYVSITGISPASQYVGIDQSITYGRHTLVLPQTAGITDTGSTLLLLATDAFEAYKNATGAVEDANTGLLRITLDQYEMLESLLFRIGDETYEFIPNAQIWPRSLNTDIGGDADEIYLIVGDLGSPSGEGLDFINGYAWLERFYHVYDAGNQAVGIALTEHTFSRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3V3</accession>
    <name>A0A2G8S3V3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_08448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3V3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3V3"/>
    <dbReference type="OrthoDB" id="3095879at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000003">
        <property type="entry name" value="Transposon Tf2-6 polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="9">
        <location>
            <begin position="507"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL28414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="81875" checksum="44F59F5B13017653" modified="2018-01-31" version="1">MDRLKKAKYFTKLDIRWGYNNVRIKTGDEWKAAFVTNRGLFEPNVMFFGLANSPSTFSALMNDIFKDLIILGKVTIYLDDILIFTNDIEEHRTLVREVLKRLAERDLFCKPEKCEFEQPKVEYLGVLVSENRVEMDPVKVKGIAAWPVPQNASDIRKFRGFANFYQRFIKDFSAVCKPLDRLTGNAPWKWEAEEQEAFDELKRRFTESPVLSMYDPDCKTRIEVDASGYATGAVLSQEGEDGKWHPVAFYSKSMSDAERNYEIYDKEMLAIIRALQAWRHYLEGLPSVFEIQSDHKNLEYWKTAQNLTRRQARWALYLSRFEFVILHKPGTSNGRADALSRRPDHQTDDADDNLDRVLLQPDRFRVLAAKRGHMSVVPEKALLRRIRECGEREQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGRVYVPKDDALRAEIVRIHHDLPPAGHPGQAKTVELVTRNYWWPGMVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNVLQLIADRHGKIIHLIPCTKEIDAEGTADNFIREWFRLHGLPRKIISDRRPQFSSKLFHAVLKGLGIESAMSTAYHPQTDGQSERWNQEIEAYLRMYCSRHRDDWVKWLPIAEFAFNSHVHSATGYSPFYLMYGFEPQFHIPMLSTAVPSADEQREELHQAREDATSALTLAAERMKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S483</accession>
    <name>A0A2G8S483_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S483"/>
    <dbReference type="OrthoDB" id="2681631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="650" mass="74241" checksum="CB503811855C09F5" modified="2018-01-31" version="1">MDPWEQLLASYVAPHQYPSLTPSPPPVLHAIYAREAREARSAQDNSTLSTTTLPSPIQQPKSPQLPHTKPRVPPNSRASRQQNKHQDQQLRYLEHLLHELVHVSRPLEPVERAGSPYPRTRPERHREPSPPPTRIPTPVQAAKSAEVPPVAGSSRLDYQEPAEDPPSPDLTPIPDPIDNQEPSGRNRSDSNGLTQALGNLGLHATPAPTAQDPVQPARIRQSPRPNRAMLQEFSLDQATREWIQNEIADVFTRLRPPTTGRKHAAPRLAPPEYFDGISPDFEQWKSDVQVYVAGLDKDAAISAVLGLIRGTNVNRWKRNLTQDKFVANGNSWNYTDIAAFWAELTMKFRPINYVNDAIIALDQIHMGSRRAEDFFDEWEDLASRAGENKDTANNIYWLKNALPSGYLVTISTMPTKPATYAEWKSTIINMDNDRIIFNRQIHDFTRRPPPQRPLPRPPPRYSQPQYAPPRYPPPRPQYVPRAPQYAPRPAPQYYQPQYPPPRPYYPQRPQMPMMPGDRRTGTGVTYGGAGQPMDIDRLNARPCRKCGAKKTEKGTCGDMWHIPNRTGAAALQKRWWEERDSREEFLEEIRRFHQEDPEDFLAQTTRMEIPSYCEEPGPPMEHPTEGYVDSYDEIRDQMDDYEQHFPYGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4C3</accession>
    <name>A0A2G8S4C3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_08671</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4C3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4C3"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="4">
        <location>
            <begin position="27"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL28629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="39935" checksum="777FB6168736F28C" modified="2018-01-31" version="1">MPAQTIPAVAHYECAPETKEDIEYAAVPIIDFTNAHTPEGRGELAPQVRDAMRTHGFMCLVNHGVTQAQNDRMTDIADVPFSSVPAGEQAQFASRTKELGELQGYKPRGSWHLDNGVRDQIQHYMVVHPVFEQQHPKALHPFLPEIHAFMEHNQFNIIYPILRMLALGLELPEETFVDLHPFEAKGTTLHEEEAKTKNVWMKGHTDTGSITLLWSQPVVALQIMSPDGKWRYVRHVPNSIIVNAGDTMEMLSGGFYKATIHRVVQPPRDQRGHTRLSHFYFAYADADVRLVPCAESSVLQRVGITRKCRDEDAPTMRTYRTMRASMYGNSEVERKDNGVEEQVVGGVVVKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4N5</accession>
    <name>A0A2G8S4N5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4N5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="88" mass="9809" checksum="B9288BE0964E72AB" modified="2018-01-31" version="1">MDDHDVLVVVSDKDMNTRRGGRSAQHEQEEETQRFYSGQYSGAEHARARSETMDQYPRQPGHAGARNGKSPEFEGVLLQAFESGANTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S533</accession>
    <name>A0A2G8S533_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S533"/>
    <dbReference type="OrthoDB" id="3257613at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104:SF2">
        <property type="entry name" value="CXC3 LIKE CYSTEINE CLUSTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104">
        <property type="entry name" value="SI:DKEY-29D5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC2-like cysteine cluster KDZ transposase-associated" evidence="2">
        <location>
            <begin position="580"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1128"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1328"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1352" mass="151932" checksum="E4F0182654B5E357" modified="2018-01-31" version="1">MSLFNIDRALPLDGPPTFSDGRVAALDGKKSFLITSPNTDFVPEIVQGIVDVILRSDGKYGPMDPLQWPQIFTPRYRYLSAIPKRVPDSHSWSPMFRAPTQQDFVVITGTPVAGFGLLRSQFVAPLRELASTMSQHVAEYLFDRDIQQSQELRWHEVAMRHAVSRLALMSSTYLDQVLQVAELQRHWLMAAGYLEYERRVKRLPTIGRGFSCADHAMIGAWTSDPQVVQSLLAANIPVWFVRHIHLLHDDIHIDHVSPLLQPTALCFDHFPGVDNVLFHRLVGESHLGSMMQGGHGYLDISRVPSAAVYALSDFAGVVSNREAKTLSRPNAQSASTSQAPPRVVGSQGGRALAPTRIRPKPYDAAPNRTVHPSQMRGRDKFLEFPHKWMPPPIPSWSRAMSDTDRSMPARPADEIWGYWIPDPGLLLGPKDESRQRLYISNWVRTRPIWLYLLHVPNSRACKVAPQFWRSFLNATSLCSLLVHLQTPLQMRGVGFKKTRNTKKTGARISNPGGPGLKCSPTPWIPGKCFYFNVWSRIAIYSISIHPTTVHCVTIHAIVNYVVVVYAAFMSASIPHPNAGPVEYQALDAQLFPGSLIYPNTFFTHELLRDAHLDVLTSKKSPHDYMRKVDRKTKQKAKSRYREFNVVFRLWKHLQMVKRSGSCHGVSFPNRPDGVISVPCFACPWPGVNLPDDWEKTDANLQYIYHMFMGADGNHTLHKKSKHDDKTDYSLSEGRAFFADGSKMADFAKNNRKERRTIVKTCSGFKVTRSQRAGKFRNMDISGVVTILCLRHGCFFAKAIVDLVGNEQFQLVDLAMAGALESAKRLLEWLLSYDVGCTYLVNLVKRWDEWQLPPEMHTIVEAMKILLPQMHMLAHKEDCQVDFAMCYKQGDGHTNGETVEVAWSILQDAGRSTREMNGGARHDALSDFANGYNWDKMVGLAVYLAQKLREKLLLQLDQARDFAGLTYAAGADLVWDWAQLDIEDKPFTPGDYTERTKSRPAEYRSVYVLDQHEVPSEGQEYEKLILAAKEGITTVHTDKAVQQAGVGPKRGKARCDGLLSQTEVAFIHLGIQISRDQVALKMRVNAFLHARDGTGTSSDTTRALRSARSTLQDRLRKFHELALEEVDDDTAYDEEDVEEDHDVTQADDDEEYRLPKHGPELDVLALPSDLAADVFERAQCSTLAVAELRIWIGVAYDLIAMLKEALGRKSALVMSKRKYARGQKDSIAANNQITTAHLEVHRLAAQYNDNFTRMNSLSTRLSSLSVTAAIPKTLKMINVATDLGASMPLIPSNSENVGQRSGFNLQAARNLGDHSVVGSWIFHITPPKDGTKESQDAWESESKDLYNNQHEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5E7</accession>
    <name>A0A2G8S5E7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5E7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5E7"/>
    <dbReference type="OrthoDB" id="2752085at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="47617" checksum="26C4E1C83B3E102A" modified="2018-01-31" version="1">MPPFLPCELTDIIIFHVDDANSLCSCSLVCHDWVAASRHCLFSDAHMLSPSQYDALVNRVLRSESMYPWLSSMRTLELDCEDGRWFKKRNGGPRYRFFHEFAGHLPNLHLLSLVGLDWVRSPLHASTPSALSQFPSLVELRLENCTFQSFDMFRRILVAIPNLSTLMLYAVQWPSQPNGLLPGSRMLPQRRPCLVAFSIQFYAKNDCAGTLFDWLVNCTPSRSTIRQLRFTLGGSPSASIKPEHAQFLESVSASVESLRIQARDDFPISCFSKLSPLTIKGSWEGILRTLNGLNGPLRVLQIESAPTRVLSAVDLGHPASLENEDGGADMTGGLNELDTLLEDDRFKSMERLEFMISPVPSEFNFMLCLVDGHFRESIEERLPKLCKEAFELSTWIAHIELGVKEEVDGTMAAPRGPLVAAKKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5N5</accession>
    <name>A0A2G8S5N5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5N5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5N5"/>
    <dbReference type="OrthoDB" id="3044497at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="307"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="648" mass="72205" checksum="D72AD5FAA1E9EC22" modified="2018-01-31" version="1">MCMLGVPSVVMDWLRRKLTGRRTRLKFDDYESAPFNIHSGIDQGCPLSVILYGFFNTFLINSASVKHGEIAVGSMDDVALITVGRNFADTHAKLQDFFARPGGASEWSASHNSHFSLDKFGLLNMTCKVSDALGPHLNLSDATIAPSSHHRFLGVLVDHRLRFHQHTAAALGKGMVWVTALHRLAHSHMLYAIDTFITPITKPDGTQHCRGSVGAVKKLGRVHREAVILITVPHPLISHVQCAAARYVKRHCSQLHELLNAYVSPDTPVRMEKMCPARFHPDTTPAAQVLTFDDRDRALDEDEKWMREHKVSVYTDSSERDNMVGAAAVLVRRDTAHKRTLRYHLGPSSEYGIYEAEIVGVIMGTELLRTERTVINGPSVAQDNKSSIEASQQIRTRPSHYLTDYLLQRAEVLRMRGMTASVQHPELTLRWVPGHKGVKGNELTDLEAKHATRGVVENSSNRRLPCLLRRPLPISAAKVKLAYLQSLNEKATKSWRDSLRGRRFLSIDPALPSPKYMKSIKSLSRRQAAVLFQLHSGHAPLNAHLHRISHAPSSTCPTCNSAPETVLHYLLICPAYANARNRYLSGMGRCSRDLSALLGTPDAWLPLLHYVGATRRLAHTFGNVAPQQEQHEQQQVPGAARRRGRTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6G3</accession>
    <name>A0A2G8S6G3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6G3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6G3"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="429" mass="48369" checksum="B3E301E1AE81D5B6" modified="2018-01-31" version="1">MSFTEQQIEEEQIHFANVISTFQQYAPYAVNANNRRRKDFHTLPLADRELLQSLGYTDRISAVDHAIFVNAEFLNHVIASPEIFSGQDGNEDEDDPELKGNDQEDSDDNRGEGPSHAINHSHSHSHGSHSHSHTHEHHAPSIAPVYGAQGQQRKYRPTEHDMDKLRSTIKQLVRDWSIQGKAERDVCYEPMKEALIQHFSDIPLEERRNFRVLVPGAGLGRLAWDVASLGFACQGNEFSHYMLLASFYILNRTDEINKHTIYPYIHSYSNNPNSDALLRPIYIPDVLPSSLPEGADFSLVAGDFEEIYGGSDPLVADDGDPSAGQWDAVLTCFFIDTAKNIVNYLRIIHRILAPGGVWINLGPLLWHWEGNTTNDPSVELTLDEVKSLARKIGFEISNERTIDTTYTNNAQSMLGYVYHAAFWTATKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6V0</accession>
    <name>A0A2G8S6V0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_08417</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6V0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6V0"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="15"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL29475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="517" mass="55738" checksum="5FB06DD1072C4C0C" modified="2018-01-31" version="1">MSNEGTFQNIRVYWLAFVAYWGIVLFGYDTGVGGGVVAQPYFQNHFGIIKNGVKDTKRANDVSSNVVSVLQAGAFFGALASAPLSAAIGRRWSLFIWTLVFSLGAILQTVAGGSRGLGYIYAGRVIAGLGIGAISAVAPAFVSECCPKDVRGRITGMFQIMVAIGVMLSYFINLGISLHIKSGFAVWRIPFGFQLVPAGLMAFGLLTVKESPRWLASKGRTDEARANLAYLRRTHADDAGVREEMAEIEAAIAEEREARKGLGAREAFLGKGNFVRFVIAAVIFLLQQWSGQNSVGYYAPQIFSSIGYTGTSNSLLASGIYGIVKVVATAIFVFLLVDSLGRKLSLFVSGMGMGILFFIIGALLKEFPPPASGSGAHPPPASKAMAAMLYLYVCFYSMGWGPLPWVYVSDIFPTRTRHYGLATASASQWLFNFVVAKVTPTLETDLGYKLFLMFATINIGGMAVFSLLIPETKGRSLEEMDIIFGAVQADKRRADIAAQARALGKEVSSERSVDQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7J3</accession>
    <name>A0A2G8S7J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7J3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7J3"/>
    <dbReference type="OrthoDB" id="2748152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="252" mass="28323" checksum="D55C8AF0F6D98A05" modified="2018-01-31" version="1">MSAITSCAWSPDGTVIASGDSTAIVRIWDASTFRPLHVLDTTKTMTYKVSEKVQVTFTRDGRWLGSVSNTQYCIWDPRSGKLHKVIGPDSPQRYIRYDLMRSVPFDPEGLRIATISWSGMVKIYSIEDQLGGPQLILRPPGGTNEVAFSPDGRLLLAAMKDGTVRVWDTRTGAQVFRLKGHEREVHTACFSPCGRYIASASWDYTVRVWRTRDRACVSAFQPRNARVSHLAFSLDGNTFFFMRDGGTIWFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Y1</accession>
    <name>A0A2G8S8Y1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Y1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8Y1"/>
    <dbReference type="OrthoDB" id="3223825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="26693" checksum="54B59CB425CCBB47" modified="2018-01-31" version="1">MLVDEVIVFRNRTLDVRLPYQLSLSIFISPSTTPHPRPSNSRAWPNQCLQRTRYNMRFASPIRVAPPRPIPGLRLPSPSVLRLLRIKPRYSDRRGYVRGHLRKNTDDTLCELTGDDEAGMYWTLEDYIESVVLQHGLKLRDIRAYAPRAPMGIRDSVRSFVRITEDEWMAASLNAKHLAPAPKYAQCKSPGGREDIGRGRYRYKTHPYDLPLRRPKTGPKTPKYVPAEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9J9</accession>
    <name>A0A2G8S9J9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07627</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S9J9"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="284"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="452"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="1377"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1847"/>
            <end position="1885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1949"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1279"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1303"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1949"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1994"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2047"/>
            <end position="2061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2061" mass="230171" checksum="FDD2A760ADBB471F" modified="2018-01-31" version="1">MDARFHLLDNDAFAGRIPGALPSDAEWKGFKLPKLKKGMLERDIYLQLGAVVQSVLEAAECTKLQFLDNAHHKSKDGNHGRTETFNDAGIYRDTGFAHDATDLDAKPPAKSKKSPAQLKERLPEARSSFWVDVPVEVKGDEKNSAFYFKSKPKPKGFCDQSDQPAAVESQEGGRLQEEKEEAEVVEEADQAKKDEDVEAKDEDRGDQGLGDRDSEAERKEEKGVGDDGEDDSDDSGDSAVGEDDEGSESGDWRTPEDSKPSTRDAVLSFLKTHYPPFVNVSDDGIKALDQFIERQLNIFRCQHRTFCYSIYICFDMARLLYFDRAGAYVSHPFSWVEPTSLLHEFVWKFAQFANADKLGKMGHDPTATVVSAETRLKFIKQAKNAALARHIRAGLKKASEDGCPLYELVVQDVAPSPDEWFSDEPFPELPTSPSSDQSEDSSSGDTTATVVHRFIVGRPHFSADTLVGRCTRGYMAFDVTDPKKWVPCFLKDSWRRCVPHRTRPEHSVYERLKRKGLKPTDGIATLICGGDVGGFRAQRTRVQQKDIPETNKPVRLIHYRLVTEDIGLPLSEFDNFSELSGTFVGALRGHRKAWDLAGILHGDISVGNIMIRVHSDGTRSGFLIDWDLSRLACELFKGPVKPNPIGTWQFRSALSLQYPRKPYRRSDDIESFIHVYLYLVLRYHPTCVVNLRNEVQHLFGTRSPFAKETRVGGSAKLMTLMSGYLGFMVIGNARLQRLLDDILHHCRMAYKHIDASAMSRLYGPVPQSGPDAHHDMPPKSSTPRLMPSVLRPSDFPDTAAWLDHLHGRARRLFPREDARSAASAPPEPYEPEVGPFLSKPRTLMNLFIEHAESEAYKYDDKAPDQFVFRTAPGNFWPSEFRQLRSVGTPSVAGSFESEDDKADPNARSSDSDVTTAADARVTVVGHGGGQSESSGSTADSKRKHAEKHGEKDGEIEEDEEQGSAVHLFAGLRTYALSWNLPLGLFVLLLQCVPIGINLSLFHFGVMGIPLPRIGCELNDFVTKTLSRRTTQPFKMQATCLPSPNRLLSSGAGPAPADGVQVPQVTERPSFVRHCPSSTNRDAYKQKTGRQLAPLLIDESGMGARFHLLDNEIFSAHISGAAPSDADRKKFKTPTLKKGMLERDIYLQLGAVVKSVLDAAKCTKLRFLDTANHKSKDGNHGKTETFNDAGIYRSDTGLALAATDLDPKILAKSKMSPAELEERLLGARSWFWMDVPIEIKGDEKNSAFYFKSKPKGSWDESEQPAATDEKPPEADGQEGGSRDVEVVEEPAQAKEGEDEEMRDEGEGRRGDEDGRDEHQEERGVEDGGYDFGDDSGRFEGVEHEDAGGDKGKEREGGKHSTTPAVIKRHVPPFIKLSDNGEQALAQFVEYHLNVFKYQHRTFCYSIYICFDMARLLFFDRAGAYVSHPFSWVERTSLLHEFVWKFAQLANANNLGAMGHDTTATLASPGDRRKFIDEAKSASLFPHVRAGLQKASEYGCPLYELVVQDVPPSRDEWFPDEPFPEPPAARSTTATSVRRFIVGRPHFSAEALIGRCTRGYMAFDVTDPKNWVPCFLKDSWRPFVPHRTRPEHLVYERLKRRKVEAADGIATMICGGDVGGFRAQRTEVQKDLPNTNRPVRRIHYRLVTKDIGLPLNEFNDFGELSGIFTGALRGHRKAWDLAGVLHRDISVGNIMILIHKDGSRSGFLIDWDLSRLECELGKGPVEPDRTGTWQFRSALSLRYPRKPYRRSDDVESFIHAYIYLVLRYHATSVGSLKTKVENFFEGVSQIDGIKIGGDDKILVFIAGQLGFEVTGNKNLQRLLNYILENCQATYANIDYPEMERLYGPTQATEQPADPAQREVSPEPSQSRQMPSLLRDDEVPNPDEDLRRRTRLWGLEADTEPAAPTDPCKIDSFLEDPLELMRVLNDHARVAYGRRDKAADQFIARKSQDVFRPPENDGRRKIGEMSVTGSFPSEEALVDPVAAPASDAEASPGPTNDEVSPANSVASFVAEGGHSYDVPAVTPRTKRTRADEEEDIVDDKAESSGWRRRSKRIRSRKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9T2</accession>
    <name>A0A2G8S9T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9T2"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="499" mass="56064" checksum="E0FE7C3570E43A6C" modified="2018-01-31" version="1">MALLPINLRDLNGYSVKSDNINGTLCLRYVARHYMVFGLTAFVVFMLLLGKLSFHEVIVEVPLAEQARPESSRWSGLRLPPLYSQYHEHELSLPQHRWHAAWHEGEPKFLFIPGHSRGSGWGNIWQEILLNAYLSYKLNRAFVFYNYTWNDDASQDYSDYGGKPIPSRVPLSALIAGPMVGGAFPGTDHHASLSIAEQYYHTVCDGRKRVLDREEVHKDLGSWMVDSITEGWVRKLRTVDDQCVEVENSQGPIYNWVTFGDKSAMRAAWADFAASPVVSTFRWSPLVELAFDNNREVVAPTTISEPPLSALPYDTPNAGRYPAIPGLLVLHLRRGDYAGHCEHLAEWSSTFLAFNQLPGLEDFTPPSGSAPWGENTPENTALYRRRCLPTIPEVVARVREVQQAHAARGLENVYIMTNGALSWVEKLKVALTDMGGFKHVASSRDTVLNWEQKYVAQAMDMLVGQRAQVFIGNGWSSLTGGIVVMRHANGFHADTTRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Y3</accession>
    <name>A0A2G8S9Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Y3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9Y3"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="50"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="299" mass="33897" checksum="F294AC93B35EAFB7" modified="2018-01-31" version="1">MPKISKKSRAYKKPRLGPSSANTKAKNESKHTAGAAGINSDQHRKTVEKTGPFMSLPVDVFLEIATYCHPLDLLRLSRVSKKLRPVVFAKRNRSVWICARNSLDPPMPACPEDLSEPKYAFLVFDPVCMVCGTTSSKTDYGAGIKLCEDCWKTHVKEGYTIIRELEPQMRRDRSLKSAICNLLPEVVGSFRYYVLNRDRDAVRQTPLLKFYQPEIVARAKEYYAISQASDGDIRALEEYVERREARTLERVKFHSALFTWGYDYVRAQEAGEFASLIDKLSSGLTEICSKLDSIQPAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA62</accession>
    <name>A0A2G8SA62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA62"/>
    <dbReference type="OrthoDB" id="2754741at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="438" mass="49026" checksum="CB349E9A06E13A4A" modified="2018-01-31" version="1">MASSSSWFPPKTYQWDHIPNMMAPNPPESYAERMERTKTMAKIPDFASLAPPALPDPPAPSASTSAASSSSLAAAFIEPAQLPRRPPRTEPPAWYNPYPYPRSWTLERRVTQEELWAWHHREDDWPRVDGGGAWLIDIKHAVWSVYTNGVRARQQAARREWEEARQLANPPMAPKRKGSGVSHGRDVRFQTFDWDEGIPVKALIAGRRALQHLLRDANEEPFKGLRYDTIRVRMKWPAYPDYEPDRQILITARKGRGKARRRPVTRMEFLVSLGSFFTQYYAEASNMEPHPAFTHLALGPGEGKVSLYALRLMGIRAGMGGCFDLDVELDTVQPKARSDDEAEAEAEELGTSESPSPADDVSVASTSPSTPGPSTTSESDLNLDEDRAKTPPWASTLPVTCTVAAPPQVPHQNYFTHVDPLKMQAHALPAWPDVYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAJ1</accession>
    <name>A0A2G8SAJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAJ1"/>
    <dbReference type="OrthoDB" id="78296at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="125" mass="14109" checksum="544B9AE27C1AFCCA" modified="2018-01-31" version="1">MAPPIQPVERKDTVAKQYVVHEIEQAEKNSRPSWNTTMTAMFGDHADWENCRVYTAKGRPLARPTQICPITGKVAKYLDPRTNVPYADLEAYRVLSRVLRHEYVWSPALGCYVSRAGSVFSPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAP7</accession>
    <name>A0A2G8SAP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAP7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAP7"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013423372" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="21"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="289"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL30678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="445" mass="49124" checksum="356D2FA544316730" modified="2018-01-31" version="1">MRFLRTLLFPLLALTSFALARSSTGDSVLVLLDPSLKKENYSIFFGDLEKKGYKLTFRSPKDTTPEIIKDDVAQFAHVVVFAPETKTFAADVTPQSLVSLLSKNMNLLLALSPKQTPLTSLASEFSLILPPPGTPLISHFPKRDTPATLIPVQPPRAHHVISDNLAPVWFSGVPQSLGHNPMLIPLLNAPPQAFASDADSDSGADALVEAAEKSGEGLWAGSSLSLVTGFQTLSNARATWVGGVEMFSDEYINKEISKGVKSGNRDFARDVTAWTFQESNVLRIDSVEHNLVNETLPGETYTINDQVTFTAFISKYDPEIGWWRAYSDIDDMQLEFTMLDPHIRTSLPPVEGEPGMYAVTFRVPDRHGVFKFNVDYKRKGWTYLTSTSMVPVVPPQHDGYPRFLSAAWPYYAGAFSTSAAFILFVALWLAGDDRELKKNKGAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB14</accession>
    <name>A0A2G8SB14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB14"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="527" mass="55496" checksum="4B07C6EEFF661631" modified="2018-01-31" version="1">MSMTLRLGETAPERKGAGISEIIRSTSSSSNVLLCCASCSQERIEPRSLPGCRALGRRNGELSVEDGGAGEAYERLARVGKKPGREGVCGLLVSPPLSRALGIAGVGADGEATEPSMNSTSSASILSTLLSCVMILGVGVAGTDAPRAWMTGPEPPCLRADIRPRGDSGGAGMEPRRGLGLPLTLCKRREFEPLRMLPKIVGVDGELDGRDAPEAEDAEDGGRGRPVRTDPEPETGGVEVLLNFEALVEVVRTDDGDDWGLDGPLSFFSGVDGLTLIAAVRLTLSALGWGTGEIDRLDLPSPEGTSSGVSSLGVLTSSVSSSELLCRRLRGFVGDGVFLGATAAPSPSIERGLYFGRPETTRELRLRTERALIESLLLVSLPDGLALSEGDEDCSSLVAASFLSADCRREWRVMVLASGESSVRVLLVESGLSVDERAGGAMLAVLVRRAAVSFFLAFSLSFSFSFESLCMTSARALLTEERPKDWRMELRVVGLVRTDAPLADATWADMVKGCGGTGIERLYGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB15</accession>
    <name>A0A2G8SB15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_07124</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SB15"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="246"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="447"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="589"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="732"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1127"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1336"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="899"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1310"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="951"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="969"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL30955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1510" mass="167107" checksum="4E9FA63E94BFD556" modified="2018-01-31" version="1">MATVGGAPIPPEAQAKVHDIVDRDAANGRVPVHTFNPDASPEEKAAAAGKGVQKLGLENNELKTGAQEVQVDTGTAGDALPAITVEDTSRAEKKPPPVPVDTEKRPPERPGSPTWPASPTAPENDIPGDMPSGAAPEIPHWYKVGWRDISGIDVPLAAGDEKHKRLLSQFLHEQYYGEWYHNAALVVVAVLVTHFITRFNFGFGWVFIILAFCNTYYTTSMIRTRRAVRDDIQRELVKTRFTAENEIESAEWMNNFLDRFWLIYEPVMSRTIVSSVDQILSQNCPPFLESLRLSTFTLGTKAPRVDKVKTFPRTEDDVVLMEWWLSFTPNDVSEMTDKQKLSKVNPKIILSVRLGKGFASAAMPILLEDMTFSGHMKIRMKLMTNFPHVQLVDVSFVQKPVIDYVLKPIGGETFGFDVASIPGLSAFIRDTVHGVLGPMMYEPNVFTLNLEQMLSGEPIDTAIGVLQVTIQGARDLKGAKLGGGRPDPFVSLSINERVELAKTKFKSNTINPTWAETKFLLVNSLTENLCLRVWDYNDHRANTDLGCATFDLKALQQDATQENLEVQVLKDGKERGTLRLDVNFFPVLKPEVDSGGVETVPDTKVGIVRLTVHQAKDLDATKSVTADLNPFVKLYAASSPSHPLFVTRKVKHTISPVWEDSTEFLCTDKASSVIMAKVIDDRDFLKDPVVGFMSIRLTDLLNAKESGKDWWPLSRAKSGKIRLTAEWKALDMAGSLHGADQYVPPIGVVRLWLQRARDVKNVEATLGGKSDPYVRVQINNTTQGRTEVVNNNLNPEWDQIIYIPVHSIRETMLLECMDYQHLTKDRSLGYTELKVSDLAKPIEGGSGEFLYESTGLKEAEDPIKIGNNSFKGRLIYSAQFIPAYALRGIRFDSGPRQIQQEAEMSKAGTPDSTAGGSVRDDEESEIDMEMAQGRVTVSAPVEEERPVNGTGEANGNVNGATSDHHKADSVVTTASARTSGSTAVEDEKRQEQQAPQEPQGIEMSTEELLKHQAGVIIFNVVSGRLHKKARLEVLLDEGYWPAFSTARARSQSAMWEHIGEGVVKELDFSRVWLRLNEADEGDKDDVIAEWKGDSKAFLEKTLDGPAEFTLVNQDDEEKRSVVRVEAKYLPVPIQLEPRESVNNQGMVRVDLIDGHGIQGVDRGGKSDPFVVFHLNGQRIFKSQTKKKTLNPEWNENFTFAVPSRTGANFMLEVFDWNQIEQAKSLGSCRVDLDDIEPFTAVERTVPLSHAKHGEKGEIRLRLLFTPEIIAKARKNTSTFSSAGRAMTQIGALPMGAGKGVIHGVTGVFRRRNSQSSGSSDEAREPPAGVVSKRDAEGGAAAFPTGGVSGRSQEPGTLRVIVKDAKDLSTADIKPYVLVRVGDKEHKTRHAHKTATPEWNESFAFSAAPSTQPKLFAWVYDHKTLGKDKMLGMAEIDIWQHLKPNESVPTTELTVELREGQGLLHLRLEYDAEAPLSTRPSRMSLHSIAASEKLSPSRFSISGRRHGDRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBR4</accession>
    <name>A0A2G8SBR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-mannosidase A</fullName>
            <ecNumber evidence="6">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_05902</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBR4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBR4"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="16">
        <location>
            <begin position="60"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase Ig/CBM-like" evidence="15">
        <location>
            <begin position="785"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="14">
        <location>
            <begin position="882"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL31204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="973" mass="107184" checksum="769981C7800BA841" modified="2018-01-31" version="1">MSSSLEASVETSADSGPGSVLLQGHRFSRSLASAHILERSQGLTPSLVSADVLSLSSLQWSLRNANGSIVIPAKVPSQAHLDLLDAGIITEPLLGINDFTQRWIVNDNWTYTADITPLTHNLTKDQTALLVFYGIDTIANISVAGHPVAWVNNQFQQYVYDVTDLVRSPVNHNTNITVAFESAWYYGLNVTSRPDAEISPTGDFEYPGVRQYIRKTQSDFGWDWGPAFVPSGIFKPAYLVTLSPKASTQATVPASHSLLASTGSVFLEETSVEVSKVGQTSITLADQSADWVVNVTLAVRSVVPAKSPTITVAIPELRVSSGPLRVEAVPAGTNASTVLRASFTVPDDVPQRWFPHNLGTPQLYDFVVTLTLDKGEEASFVTRSGFRTIELVQTPYSQEELDARGITPGDQWHFAVNGKAFYTLGTNIIPFDPFYARMTSAQVRWVLESAVRSGQNMLRVWGGGIYQPSDELTGGYDFYAACDELGIMAWSELIFSDALYPINDFLLESVDPEIRQNVRRINRHPSNAQWAGGNEIEGIVLSVNSSLANGTHYLDEFQTLFGEFLHDIVAYTDCSTTGGVLSLDPYEIRYNNKTAGEIYGNSERYNYDASVAFDYSTYPVSRFVNEFGFHSMPSFYSWEEVLLNAEDFSFNSTVVASRDHHPPAGSLAFPNPNANQGQGQMTQGVELYLPTPNTTNTNQTFAQWCWSTQVFQSMNMLSEIAWYRRGAGLDENNLGSLVWQLNDIWQGVSWSSIEYSGRWKVLQYGLSSIYSPVTIYPFWYANNETLQVLVTSDRWEAVRGTAQLTWYDWHGEAVGSGLRVGFEVPSLNNSVVYEASGLSKILPPGRKAEDVFLLLNVSAEVDGKTVTQESYFTPTSLASANLVDPKIEIRSGKDLTFTLSAKGGVGVYAWLDHPAGTVGYFQDASTGLPANGFYLIPGIDRTLKFILNPSLSKVATPDPADFVVRSVWNNTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC48</accession>
    <name>A0A2G8SC48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC48"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC48"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="485"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="760" mass="83856" checksum="1EDDC877E81883EF" modified="2018-01-31" version="1">MSSPLYVVVPPTPISTPAPHSPGRPPVLDDHSLTLPELSHSSFEDSSVERERSSTETTIVTIYSMYEEEDASSWSAAAASAVSQAAQSRPKSRTLKDGLGIHIAGSDPIHSMPTYRNSFLEQDPAALEDSAFYDTTTAAYDLRRASLGKRLSVVDKPRISVVSTASSVQLAYASSRPTSARTSASDAGGPGRRSFGSESLRRPSGPRSRPSSSGHHKVSTSNGDSKPHPLPLESQSLEPKPLPQTPPLSPLISPPSTPGTPTTPPQRPLHLSSSPSPSQSLRVPAGDRTSPVSSPRSSTSAVSTPESRHSAVVRSEGEDADSFHVRSTYAQLDQCGVKGDGYEEGVERTRARVGGSRASELRALQALGDEHEKSRELTPQEVQLLQNLDRYGFFTTPSHDRLIAIPAAPLHRPLAHLTAAVTNGPASPSLLPRQPESPMPIKESLRTAKWSRMLVPASRDEGGNVDFWGVKPSKDHKFRERIYKGIPDCWRSAAWEILMCRFSRTGKAELRQLMAEYREALDRPSSYDVQIDLDVPRTISGHVMFRTRYGHGQRSLFHVLHSVSLKCETCGYCQGMGPLAATLLCYFEPERAYASLVRLHDSYNMHSIFSPGFPGLLEAIYVQERLTEQMLPPVYAAFKKHMISTTSYATKWYITLFANSVPFQTQLRLWDAFLLEGHDIFVVVAVAILWVYRDHITSESANFETVLSLLSSFFVPEDEDAFMLWIEKVLNDKKVRADMAQWRQNWSRMVASGEHNSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDF1</accession>
    <name>A0A2G8SDF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDF1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDF1"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="60"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="559" mass="62698" checksum="694BF71311929A65" modified="2018-01-31" version="1">MLFAINCVLDRKYQNSRPSTCQALLLLAVRAFGMGAMDKGWLYSGEILPFGPSISSVDEEPLFAGTALRMAIDLGMNRNADNWTIDGKHPLFTDVEKQIRKHIWWSCCISDKLSAVWLGRPITFRANDYSTPLPNINEADETELWQPYPPGVLGNFTPQTARLLTSFRQACQLSVIITDIMDKVYPVQISAGTSRLVLLEELETRLNKWLIELPHDLVYSPNAIVLPHILMLHIEYNAAVLLLHRAFLPAYDENVSHQSALQNDPLAMKAFEICTGAAVQISAMAESYSQMYGLQRAPPFMCIYLQSAGIMHVVALAQQPSDPQASLGLKRCIEACKRIERIWPFTTRLRTLLEGARTHLNEYKYYPQTGGGRKRNLDDALGNYKNPDVSVRDLYAMPPVDSHSSTSSSSSDNWDSAHHARMVAHSLGVRAPETEVSTSFHPGYQWWPSQLMATEGLQHIPAPAPTDVSAPSYGALSGFSQQQQQQQQQQQRQQQQRHTPHPPPSHLSQSSAGMPEPFTYSQDHMSQEFVHGVNYPSFHLDRHYPSQPSGSRHDSAPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDV1</accession>
    <name>A0A2G8SDV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDV1"/>
    <dbReference type="OrthoDB" id="10516395at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="16577" checksum="AB855227DF60B94A" modified="2018-01-31" version="1">MSLPKPTSINGACLPPSMNKATQDVLPLEVSTAVLPQGHLLAPWQGEASPVSTSPACSTPRELEEPPEDLGLLVVADGDEDIDFLCTSIKQDSDGKQPGKFARVEVPNGFFGFQPDEDDGDDDEDEYQPKGSFNPPTKPQPSTIRTTTSVGKPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE09</accession>
    <name>A0A2G8SE09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LSM1</name>
        <name evidence="8" type="ORF">GSI_06708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE09"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE09"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="15681" checksum="EEECC22BDC21EBFB" modified="2018-01-31" version="1">MDSLIPFTTSGSLVDCVDRKMLVVLRDGRKLQGVLRSYDQFANLVLEDTVERIYHQDAFAEAWRGLFLIRGENVVLLGEIDLDQEDEIPLRQVEWTVLEAYHKQDVANKKRREDIKSQVLYEQKGFCKEGGEGDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE33</accession>
    <name>A0A2G8SE33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE33"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE33"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="333" mass="36075" checksum="40DF0C9EC68D33EF" modified="2018-01-31" version="1">MLITLTSPIRSLARSGFAHAARQPSVHTFRFYSILRTDVLSSSKRPSPTAFTFSKQSRTLLTDAKPVVYRPAPSEAWKKYAITAATVAGTIVATNAFLNRETRDALSQAERSYLHESFQYTGGGLAITALVARAMFKNGFAFRIMSANPWMVLGVSLVGSIGTMMGAMYTPPENTVLKHAFWLGFNACQAATLSPLFFMSPAILSRAALYTCGVVGSLSYVGATAKNDKYLYMGGPLLAGVTVVALSSLAPMALPLGMRGLAISEAISLYGGLAVFSGFVLFDTQKILQHARLAEQGRMPRDPLKESIGLELDMINIFIRLVQILGSRQNNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEL7</accession>
    <name>A0A2G8SEL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEL7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEL7"/>
    <dbReference type="OrthoDB" id="2755591at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="185"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="325" mass="35210" checksum="77256B980721AF46" modified="2018-01-31" version="1">MATSSSGSAAGAEAAMLAALASQLQLSYGALLLGSFLGFILYGLFVHQTYQYFRRFHADPSYIRIMVILVLILETAHLVITSHLCYAHLVTNYFKPETLLVGGWSLNIIPVLSGVTIILSQLFSIRRVSLIGSRQAIVAAVVALFLLGEIGFPIASSVSAFSYGTVKGIKPVTYLAACGLAMVSIADAILTVTLVLAIRKTRADYDRRRTGESLSDIVQIYLVNTGLLTVIFNIITTIVAFTRPKTMLLGALSIVVARLYGNTLLAILNSRQLHGMELFAGRSMVVSIARAKREASQDLWSAPRIPQSVPAKIDIQVMTQMEGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF42</accession>
    <name>A0A2G8SF42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF42"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF42"/>
    <dbReference type="OrthoDB" id="3064098at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="155"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="310" mass="33519" checksum="D664F631ADB0C398" modified="2018-01-31" version="1">MAPVMPPSPLPHVDSVPPIDNTFGAILIATFLAIALYGLVVHQCYQYFQQYPKDSVWIKSLSVRDFSHCAQYTHLLLSVTTGIVAVPSQIFFARRIFCLGSQRYRILVVMALILLAGEFGLLCAGTVETFIFKAFAEFESHSHTWLIPAGAGMGVVADGFITAVLVNLLRSKHIGVKRMDHLLNTLILYTINTGLLTGTLDLLSFVFGVVYPQNLIYAGFGIVTAKSYANSLLAALNTRNALRYGPNCALTISAAGPNTPGPLAAPRQEATDMSEVTQVEAQDAGVMSQKIEVSENSQARLTLELVGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFH2</accession>
    <name>A0A2G8SFH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFH2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFH2"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="12259" checksum="5EEAF5FCDB4901FE" modified="2018-01-31" version="1">MLSDWESSLTELSDSEDEYQPAPSKKKKQKPPPEYKVTGSLQPYRTTTYTTRSLYDQIIDGTIDLDPEYQRANNASHELSPIIRNVKGVRRIEERYTPFHIGKQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFS6</accession>
    <name>A0A2G8SFS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMODS and SLOG-associating 2TM effector domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFS6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFS6"/>
    <dbReference type="OrthoDB" id="3245801at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041622">
        <property type="entry name" value="SLATT_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033635">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18142">
        <property type="entry name" value="SLATT_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMODS and SLOG-associating 2TM effector" evidence="2">
        <location>
            <begin position="513"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="673" mass="68850" checksum="82DE1870EFB10F26" modified="2018-01-31" version="1">MSSDQQGITHPAVSPSASDETTTGVMRPASQPDHADTSSLTATAPPQPATSAHIAPSSSPHLENVESALQSQSTSSSVTAPSNQPAPSPLVPKIATESLPMSTPTSGYYGGGSGGDHHPEQFTSSPYPISPSSAHIPGSGVDTSPVQNTTPIPVLAQQTNTYSATVPTSESTPGPVTATSSLPSKSPNAPIVGSVHTQRDFHDSGPATAGSAVLGPSRRPTEQSIEESANEDEDDVGPSHGNILAQTQAHGYEHSFLPVAGPSGQTNAVTQTQSQRTASTPPHEHPSYVPPPARGPTVHTNVGDVGNAAGIGAGYTSGAGNGYNTPALGTRHGQRAQSSSPGRRTSSRTVSYTEPPLPSRAADRYPLPMTTPAPNTNPPVPSAVGAAKSLPMPPPAHHGNGSGDLVMSPQPDATAMHRSELDWAVPYMSGSHPAGHGNAMGMQGMPGGMGGANGTMPGSRHDSRRASAYTANGGGNGTPGAHRRSMSMAATLVTANGGEKCIADRLIPTLEAAERELISARRTARIHGWALNAAIGAQVVLGALTTGVAAATTGRSTSVATSILGGMSTLAASYLAKARGSGEPDASAKRAQDLESFIRDLQAFVLDHGHLTVGAGDGVQPEYGAMVARYRRRFEEIMGHALEGVEDTLKAEKQKEEMMTAVASRAKAEKSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHS5</accession>
    <name>A0A2G8SHS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_04751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHS5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHS5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="549" mass="62024" checksum="49C23A9DF0D5F645" modified="2018-01-31" version="1">MSFSFSLSGSLAIAAFVVAFILWHVFRNFFTRSPFDNIPGPPSSSWITGDTLKLFDHDAWAYTDDLIQTYGPVSKIHGVLGARWLHVYDPRTLHAIFVKDQEKDVFTRDIAFTTGLKLLLGTGLLTTAGAEHRKQRRILQPVFSVAHLRNMTPTFYDITRKLRVAIESRVRDGPQKIDMVSWMGRTALEIIGQCGLGHSFDPLVADAKDEYAEAVKAFLPTTLEMEFGRILLPFIDYLGPAWFRRWLVSLIPHESVRRMRHIVDTMYDRSKEIYEAKKALIESGDDAVLHQVGEGRDVMSILLRANMRAAEEDKLGDEELLGQMFTFIMAGVDTTSNAMSRVLHLLAENPAIQEKLRREVVDARETYGEDIPFDDLMALPYLDAVCRETLRLYAPVSLSIRVCHADTVLPLSEPIRGVDGTLIPEVAVPKGSQIVINLRAVNTYKAIWGEDALEWKPERWLNPLPRSVEEARVPGIYSHVMTFLNGSHSCIGFKFSQLEMKTVLYVLVSSFKFELSDTKIHWNFAGVVYPATSKDSVKPEMWMNVGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHT7</accession>
    <name>A0A2G8SHT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHT7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHT7"/>
    <dbReference type="OrthoDB" id="3265112at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33096">
        <property type="entry name" value="CXC2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="903" mass="101469" checksum="6FDC2CD53C623FFA" modified="2018-01-31" version="1">MDVHEPPPPDLDSSPNCDSSPGEVETFPQPESSSRRLLPDEAAYRLYSNWLGLIPTLDEDYLGYMERSQGRLGRPIEMEAYQCKGKCSLSVSKDWDVQCLYSDFLIETSSTVWIKTLAEVLVIVLVNVRENVWTDTLASVRTGIPANAPVNFLVIVPAIVPTINPTNVSVTVPADVSATVPENVSMDASTIVPMDASTIVPMDASTIVPTDVSTVVPTDVSTIVPANVSTIILTNVSATVPKTILATIRLVFGTGPVARRWPRALPIVFCSRDAPHVLAGGNLDGSLTDATFGQRHNAAAGDSPWFYEPKYFIRKENVDRMEVRITAARKKPPRSYKSQVPESALDECEKSYEAADEKKEKTCGTKFDDMGLMALKFSIALIDHLFAHLPKEATVVVYYDIGCVLDRSLHKFDILPGSITSRLLFAISAMHAYGHQWACQLVYNPRLQDGLGLTEGEGTERVWSKFRMLIGVTRSSGRSRRIWILDRHADVVNSAARENLGGWIRGRLKNGVEARGSTADEDLSKIDISISELREQWSEQRAAQLAVRNHAPARLKRELDAVLTLQTELDSVHQYFHHVKKLISENSNPEAPRFLESLYRTHKETVGKVEELYSSLNVTDVFPEIQGLPLEFVRVLLMARDLKINIRKRAIGTFFEWDKLDRASGTKLHQQTRKAISRRTPALLTGIRKFNKYCADLKKLYEPAWNFPLPSQLPEELNALREDSSLLSDVWVTKVAPTTPQWLENPDVRTGIRAVLAKDRCREERRRLEREAENCCQWYGRELAATELAMRLSKNAAILFLLRQQKEDILLLQFRWRTPFVSNLRFQTQTSEALRLAEGLSGSSATVPIRWVRLNFQHDLEEDEGPPLEEVTEEACLAQDVLEVVSDHYSRDHEDTGCLPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ20</accession>
    <name>A0A2G8SJ20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ20"/>
    <dbReference type="OrthoDB" id="3239894at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="794" mass="89402" checksum="F7DE82F3E5CAD50A" modified="2018-01-31" version="1">MDPHPDDSDGPDVMQIDDQPEPICDDDWEEAESDSEHEVPLVDDPPVLSSATAPSSTGMASSTLNHLPHPAGSDGQPIPPSVNVPPPPDHMPTEPVHVEEPVDPYLSTRPPRPPFSLVLCDWHPAVLLATILCAWLHLSGHLPFRFCDVVLTVIAQIFRELGHGTLIPSLRATLAGSLSSLQLNPQFQIFPTCPHCLKPHPESVYDDIKSKCFLCSTSLFTLDGNPLLRFPYKSLTEQLTAILAMPGMEEAMQAWRRRRRVAGRLVDIFDGLICRALRGPDGRPFFRYDLPEDPDDELRIGVVLGLDCAGMGLIKSHRFSYVRSLISQSYTSGPMSFSIINLEPHLRFRAATLLLSAIIPGPKESNPDQTQYFMVVVVNELGRLWRTGASIPTPSRPGGRIVRVILAGVFCDKLAAHKVGRFGSHNHRFFCTLDWIPQSLKATVAAFTRNAFRSRTDTQHRVVKTHFYHIWVQLKILRKNHELRDLHKILKDLSLPANLGRLPRLIGEPAGGSLTADQWLILAVTVGPLVLPQLWQNCLPDPDGVRLKERREQIDQILLQRKENRKKKVQPAANSDQLAAPEREGVPTRPSQSRRKKPSRAKKPLDEAAPVRRSTRESRPTAKRQAMVLESDDEGAMEISEDEVYPSEDDDDNASTMSTNGLHPRDLDVFLKLCSALTQFLANELTTQNVEDADRLLREYCIELLEIYGPGVIRPNHHYATHTGDFVLSYGPLREFWTFIFERLNKILKSYKTSNHDGGQIECTFFREFHRTAELYRVVRFSGTFRFLVHVSHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ78</accession>
    <name>A0A2G8SJ78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Necrosis-and ethylene-inducing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_04435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ78"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJ78"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013822640" description="Necrosis-and ethylene-inducing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL33810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25434" checksum="96ABC9AF931C4836" modified="2018-01-31" version="1">MTFWTFGLTILSAVLLAVGTPILPRAVLPHDEIVGFPETVPDTRVGQLYLKYKPHLYVANGCVPFPAVDAEGNTSGGLEPTGDPSGDCSSSTGQVYARAESFNNAFALMYSWYMPKDEPISGIGHRHDWECIVVWIDDPNKDEPTLLGVAASAHGDFATETSPAVDGTSPLIEYVSFFPLDHQLTFTSTEGGEQPLIAYESLTDAARDALETTDFGSAIVPFKNATFEGNLVKAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJB6</accession>
    <name>A0A2G8SJB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJB6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJB6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="329" mass="36813" checksum="FB3E58859E22086D" modified="2018-01-31" version="1">MLQVVDSSRVTQIQLCSGLESICEHLGRIPRSLKRIGCDFCSGVARTDQDGTRSLARYLKPLLAFSLIEHCHLIFHHTPPSVCDTDLALLGDVWKKLQSLELRHTRHILHGWAHPTDVQRPTLFGLIELARRCPGLIRVHLPELDARTLPKTSRVSRLGHSVREVSFNHVHYASTHAERPCAVAAVLDTVFPALDVANSMFACVSTSASAHLDFRRPGVKEAHSEWWQVMKIVRAMQLGRRHRDLADCGATFGSDFSASTTGVQNLDWELNLDMHSDYWEPEVDSHEGLCVSTEWEEDSDFDSPHDLVATTIFGHSESDFSSTDSESST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJJ4</accession>
    <name>A0A2G8SJJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_03650</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11 14">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="11">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJJ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJJ4"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00692">
        <property type="entry name" value="ligninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="4 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013424076" description="Peroxidase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="15">
        <location>
            <begin position="68"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="40"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="60"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="274"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL33942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="364" mass="38293" checksum="3E95299631311E5B" modified="2018-01-31" version="1">MFSKLFLSFVVLAASAAAAVPSVSRRATCSNGKTTANDACCVWFDVLDDIQENLFHGGQCGEDAHESLRLTFHDAIGFSPALTAAGQFGGGGADGSIIAHSDVEMTYPANDGLDEIIEASRPFAIKHNVSFGDFIQFAGAVGVANCNGGPQLSFFAGRSNDSQPSPPNLVPLPSDSADSILSRFSDAGFASVEVVWLLVSHTVGSQNTVDPSIPGAPFDSTPSDFDAQFFVETMLNGTLVPGDALHDGEVNSPYPGEFRLQSDFALSRDSRTACEWQKMIADRANMLEKFEVTMLKMSLLGFNQSMLTDCSDVIPTATGTVQDPFIPAGLTVDDLQPACSSTAFPTVNTVAGAVTSIPAVPLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJZ6</accession>
    <name>A0A2G8SJZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJZ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJZ6"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="43"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="278" mass="29883" checksum="885FD0DF05385190" modified="2018-01-31" version="1">MSPPSPAINQAFCDVSALEAGHIKIPLAWVLADVSEDEFVNAPILSFLVHHHTGPTTTFLSSTSVPARIGRTSPPAIIKQAANSRSTASVPLDVVESLAKGGTTPPNIKRILISHLHIDHIGHSALFPTAQFFVGEGSRALVADRYPTNPNSVIPADVVPEDRTTYLDPEGWPALGPFPHALDFYGDGSVYVVDAGHGHIPGHMNFLVRTSADGGWVYLAGDSAHHWDLLNGQGKMGHHSLFGCAHEDLDAAEAHIERLKTLMKENPKVRVILAHDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK78</accession>
    <name>A0A2G8SK78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK78"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK78"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="274" mass="30177" checksum="89A48F1CF477D6E0" modified="2018-01-31" version="1">MATTDNAASASAAYSDAQNVSPVASTVSRDQVQRAALLASVTGRWFEDVKFFAFSRRTRNGSVDKPLPLLANSSLIRKASSHFDFGMASAIRFYVFHRITNGLRYLVFGAGFSESGVADIDAQYPLTRPTSTETYDYASDSDLEDEEDIEGEAPSSDDDVGTEGHADVKSLRGWGKDNDGLPASKEDVSKDASALLHNSGPSRAHARPGRVVFLGDIAYTTWKSFIFYAYYEEVNFSPLKSQQMPRPKDQDPYHAPLCSPKSMYRIAHKVSYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKU7</accession>
    <name>A0A2G8SKU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKU7"/>
    <dbReference type="OrthoDB" id="412006at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38631" checksum="C79AB759A5104F19" modified="2018-01-31" version="1">MPDTSTAYHHHTEGHDPGLSPPDPYRAVPVHTPLSDLYADFDPSPPLPPPPPPLGEELSPREDDFSLYEATPDRLTPDRDCPPETRASSSPTNTTLRVMLTFTNDQGAQVRLLGPTPPNATPDPRNLPPPPKRGDNPSSLRVLFQNVHHISHQTTMLLELYNKSHDVICPPTQPCGQPPPPSSPPEDGEIIDFDAERHRLANPDPTGRYLYGTQSHPNWTLLETQRDARVTIYANKRLVNATFSLHPAFCTRDVALLQLTLRKDTQYNILALYNDQHCTAIDFLHDHINSLPHIHLMGGDYNLHSRRWDTVYPTTSTATQLAKADALHGALGHNLISPPDVVNPHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLM3</accession>
    <name>A0A2G8SLM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLM3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLM3"/>
    <dbReference type="OrthoDB" id="2790434at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24268" checksum="A2E1BA66DB0C7694" modified="2018-01-31" version="1">MVQRSTTCVMTREHVCAAIRAAFPDDAPLDVSDFRFLSIGIGQRKKMAIEDQAAAWEANRELHEKLRKGGVSFDLGPEGQGVYPLVYERFGGMDKGGADLIADGRIKVKSLVSLKHFTKSGLILSDGTELPADVVVFATGYTYIRETNAELLGEDVISQTEDVYGIDQEGELRGSYRPCGYPGLWFATGDFSNSRTLSKPLALQIKAIELGMMPNDGRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM35</accession>
    <name>A0A2G8SM35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_02597</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM35"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM35"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013883355" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="34"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="393"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL34810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1030" mass="111177" checksum="E5B61B50A2CA5AC9" modified="2018-01-31" version="1">MLLLRCYPSWVLPVLLAFCLVLLTWPLTTPSRALDPPRKSTGYSDVVQWDNYTLWIHGQRVFLHSGEFHTFRLPVRELWLDIFQKMVAAGLNGVSIYVHMGLTNPSRGVVDFDDWRALKPIYEPASLAGIFVVLRPGPYINAETSAGGIAHWITSETAGVVRTNATDWTEAFGPYIDGVIKETVDYQVTKGGPVIAVQIDNEYFQRVENQLYFQALEDQYRAGGIAVPLTYNDPNERKAFINGTGSVDIYGLDAYPQAFDCSNPHVWKNVSTNYHQYHASVNPGQPWYMPEFQAGAFDPWAGPGYDACAVLTGPDFEDVFYKQNWAANAKLVNYYMFYGGTNWGGIAFPGVYTSYDYGAPIRETRLLTDKYDEVKRQGLFLRSSPQFHKTEWVGESATGIPGVAISNSLAYGTYLRNPDSGTGFLIVRQNDSTSTANIAFTVSLPTSRGTLTLPATTGAIALHGRQSKLVVTDYTFGAAGALLYTTAAIFFAGTIGTRDVLFLYGHPSQAHEFAFTPAGAPSSFSSSPSSPLVQIQPSDSDKAGGGASVVTVLPGVQGLVTVWESDMQLVLYADVTTAASFWAPPVRSSTANSHTIPGLDAFWQFGTNATVLVGGPYLVRNASLVDTAEGEGKGAKTLALVGDLNASVPLTVFAPPEVVAVTWNGEPVGTMAQLGASGLRAELTLKRELEGEAGVKAVRVPELTGWRYADSLPEVGRGYDDAGWVVADKTSTNIPTKPAFGDGRVLYGCDYGFCENIVLWRGHFNATGAETAANLTIYGGEFFAASVWINDKFISSVFSRTDHANQLFTFPPGAVVAGEDNVVTVIQDNMGLDEDDNEKSARGIGGFELVGGAFGTWKVQGKVGGYLNYPDKVRGLFNEGGLHGEREGWHLPGFDTSLGAEWTARELSAGLPSGGAGVGFFVATFALDIPRYTDTPVSFQFADADGPYRALLFVNGWQFGKRAANVGPQTRFPVPQGILDYNGLNTVAVAVWALDDTAVSPRLTLEVDAVLEGGVGPIALNNPDWAALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMG7</accession>
    <name>A0A2G8SMG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMG7"/>
    <dbReference type="OrthoDB" id="2757285at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="660" mass="71652" checksum="6BFA2C243CA554EF" modified="2018-01-31" version="1">MTTLDAAQALQHCAPKANCLGICDLPDDVLILVFSSLHGQDVARCIPVCRRFSDLIHGDLSLQYSIELAVNGMVDGDHSLATLPVAERMQRLRQYSSDFSSGAFYRQDLTAHPDYLRQDHDLLGWPRRVIHLYPRPSGAIYMDVDRADSALYLSHFVPGSAQCGIPSSRSWFSVRDGVKPDLALKGWTVDDAQDLFVTVKETQMLMPPVVDGVPDIYIHFYALSDLKADATVLTPHPAAALPLIRLPTLDSTTPKNGSWPQIIGPYVMVGIVAETGAKQWFHFVDVYNWKSGEMISRTNIGNVHASVIPLDERYLLVFPSMGMPEPQPNLRIYTFVPSPSPSCPSSRARAGRHVCTLELAPTLPGEHAVWSQAKSGDRASEESTGHCRTDAARSVIALYIQYQGVDSERGNEEEEDGGEGDEGEGEGEDEDGPTGTPYTYATHLLIPRATLSAQIQAAESASTSRHRQMGGGAGSDGTDTDTADELAFTVPWADWGPRGSLRLYRRGALYDGQHVVVPAPFGSRLPFVVPASDSDSRNDLEHVQAESAASAGSVYVFDVNPLVARSALRSPRDRGAMTAVVDAGDIEKVLPGVVDPECLAIPYVVYRFPLPYPDPPSTQAAPGLPVAPPAIRAVTMSMAGFTVQFDDSVEYEKGFQTCTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMQ8</accession>
    <name>A0A2G8SMQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Geranylgeranyl pyrophosphate synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMQ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMQ8"/>
    <dbReference type="OrthoDB" id="420564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="50894" checksum="E7C81F9FE3679A37" modified="2018-01-31" version="1">MSYSHYNRTSNNAGYRSGGTRGTRNPPYRTSANIVSLPPDRDLMEGLRSVAIRTISKPHVDVSSGNAIKPENVKYIGSYNWEEKSTPTITVPGSPPEWRGRPFPYRVPFDTDVRFVDQNGYRMDEASCLLPIFRAVDIVAEENADTSLDWGDVDIVTDRNGLRKLMRWLQYTPGPEKEAPKEFRIDLQLGGKKTVLMNRWEKRTRENADPPKSGCGLNFERESTTPTKGCEKSTGHHRIVQQDMGGLKMIVRFEVDACIPGPASESTTSTTRATTERTAATRATSSNVDDLTDMLSGLDVSRGTSTSVMSTISQSADITVIRAGIQRSQSSIVELTTRSARYIDGFDWEEQYPQLLLSSTPHLFLAVHDRGVFQNVIKHQLGTTEFRRVENDSKIQKRFRQLVAVLRTVQSLVKEHGARGRLSLVCRDGRLEVFERTSDQRMVPDSDLERFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN09</accession>
    <name>A0A2G8SN09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SN09"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2316" mass="244235" checksum="BAE6CC3E367E6EDF" modified="2018-01-31" version="1">MAHDIPVDVDDIPLTPSTGPAARSHKFYSRLTSTSIPFINLISRFSPDITTQPTLADNTIGDEESEASQKAAPSEPKIPLYKRRWFIIMNIVIALIAIVVLFILLYPVTHAIAQRLLNSAVLNIDSAIITNPTNDSFTLSVKAWASHAGIFPATVKFNEAVTISWTNNTGGQVPLGSLFFAPLMVKNKRTYINQTVQVTVDDEAAFSQFTSAVITQPNFTWTLATKKVDVRALTFLSAHNLNFQKDVHLSGMNNFRDSITLVDLQLPRDAPGGGGIEFVAMTGIHNPSPLSIDLGTVSFDLSYDGLYLGTGSGVNTTVGTGGNNITLRGTLVPQDGSDSLAKVSQLFTEFLNSGSPTVVAKGRSALQDGGSAVSWLTAAITSLELQVPFSAPEPINPIRSISIGDMALAFSEQNAWAPNVSSRSLQADLELPFGFDISISELANTFNITTGGNVVGVLSAPPSASASQISVLNSTCTYGTVNITLDSTPLYVPDANHPAFSGFTRNIVNTVSLPFQLEGSTRAIADTSIGQLTLDPIKFNVTSSFSGLQGLRSLVEIGNVDVVGGSTEAIHLTIPVNIQNPSNLELSTGDLMLQLFRGNALLGTTLVPNMTLRPGNNTLSAQGNFTPNGTPEGMQTLDDFVGGTDVEVAVSGFPQSTSIESLIAAFESLNIILEMTGHQNNTAQATVSLMNPFTADLSVTHVKSNVSFHAIPLGAIDTPIAFSSKGNSTTESPALGLDLNMDTEALLTVVRICAVEAGLDTQQLDAIVQLGGYQYLDGLNPFTVAGRDVEKRDDDMFTGFDLPTFVDKAFTKLIADVDLQAGVSIGNHSSSHGYSQHPPLTPTALAGQYPTTLAFTQHNVSVKTDRSINLLLPIVAQPIVQKVISGAVLGIETVFIKDVKQDSFTASLQGSVTNAGPFDANITFPTGLELQWTGSSLGNIAMPAISVVANTGAIFQVDAAVKVVDPDHLTEFTKALVSQDPVDWIISGSNLSVSALGITVPGVSLPAKAVSLKGMNNLKDGVKVDSFDLPGNDPDGGIHLTLNSTVTNPSQVGISLSTITFQALFQDVNVGVVSTSSPFDLLPLSTVTLPLSGRLVPQTSQAGLNSVSALFNSFLQGKDSDIVVQGIAAGPSDVTWLMDGIKALRAQTILPNQGTLDVIKSVDMNEVDLRFTETTAFNPSMSSNDATAVFTLPFGFPIDIVAVGQNLTAGSGDNDFAELVIPKGPCTTDVAERIIHLKFSDVPFTAISGKDSAFEQFLTDAATASNVTLLLKGAVDADVETAVGVLSLTDIQLNVQTTIAGLQGLNTEPAVVTTLDVHQGLPDYLLIKVNSSLFNPSNLTLGTGDTSFGLVFRNDVIGEADLSNLVILPGNQTYTIDVHYQPQGSAVASGQALLEHFLQDRTSATTIQGSTESTSIQSLQLAMSKITVSPVNIPGLGKALISSASLVFPTNIAQSGIAQTSFVLDNPFTASINILEMSATATYGNLTLGQISNVDRSNDPIHADGHANVTSPALPFSMNMKPHSIVEFLTTAAQNNHVDLGPLPALLQIALQNSGTHSSINVTVDPNAPSCTSGHQFDVNGAVLDSLKNLEVALAVNSSVKIDDYPTDLSFSQSNVPAITDKTALYLVGAIAPPILQQLADQAALSFTQANITNISNEGFDLSLKGALAGTGPFDAQIAFPEPVDISWQGQDLAKISLPPVCIAANEGAPDYETNARLTITNADAFTQFATFLLHNPDFDWTISTNALRVTALGTIFDGVSFSKNVTFKAFNNLPGVTIKNFQLPSDDPAGGIHIETDSLIPSVANLGIDLGAVTFEASFKGTTLGPLSSTDLRLAPQSTTETRLSGRITPKSDDELAAMGELFTNFLQSQNQTISIRGNSVQPTGSSSSVSWLSTAFQSLSLDVTLPGQTLEVIQSIDISDIELAMVEQSEAFAPAASSKYVLVQYKNPFGFSLQVIQSSENMTLSTENVDAAELSLPQAPVNGGVSTGDAVTLVLSFENQPLRSLNNDAFSRFFKAVTTSSNTELQLKGSANIVARTSIGDVPISGVPIDVVTTMKGLNAFDHGASLSNFVISGGRQDDNGSFIKASLTTTLSNPSNISLETVGVELPVFYEGIMLGRAVLGTLNLQPGDTVVPTEFHYAPADANDTTAQSFITDFLQSSKQLDLTIKGDANSSPFASLVPALEGVEITTSMKVNAYVNVATALVTSTVSVDFDIANPLDTEIEITFAQADSGMDGETYVHFEHEFSSFVVPPHSTANSGTINDVLLTRGALRSIGLLGATSVDVSTVATVRIGAYTIPWLHLTALDVPITVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP16</accession>
    <name>A0A2G8SP16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="17">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_02233</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP16"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP16"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000702">
        <property type="entry name" value="ABC transporter (Adp1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF2">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013768949" evidence="15">
        <location>
            <begin position="26"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="895"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="921"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="952"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1035"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="380"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="637"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL35505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118093" checksum="090E069F8F4EF693" modified="2018-01-31" version="1">MRSSPLSRWLLPTSVFLLCTQVTQARRNVSSGFSLNTQQALSPLDVVANNRPERCPPCFNCQLDAFTCGNFGECSKFDGQCKCPPGWAGIDCLTPQCGSLADGDHRRQREDGKQCECKDGWNGINCNVCENDDSCIGFPLRGQPTGDDERVGNMTCYKGGETVFNNHQMCDVTNRKILDMLPDRPPQVTFSCDKQSDMCHFQFWTAQVESFYCQLSQCESRAQRGYDKNQTFYECEKIECKCVPGRFICGEDGSLDITDFLRENIKGPAQFICTEGQGCTFEEPGMNDLIETFFGDHYITLQCKGGECLHYSQVPGYVAPPKPDNTAFVALSVAGAGLFVLSVSAILWYAGRTHSSDFGVIRLPENESAKLMTDHVPASLHFSNISYTLNGRTILDNISGSAKPGQLLAIMGASGAGKSTFLDILARKNKKGVVGGTTLVNGREVEDADFKKVTGFVDQEDTLMSTLTVYETVLYSALLRLPREMSLEAKKYRTLETMNELGILGIKDSRIGDTGRRSISGGEKRRVSIACELVTSPSILFLDEPTSGLDAYNALSVIDSLVSLARDYNRTVVFTIHQPRSNIVSLFDQLIVLAQGKLIYSGEADKVTDYLAEINHPCPLGFNVADFLIDLTMQAGMEPRSQDTQSPPELAQAGEEESNIRDEERAFSRADRPSTSSLRSAYRNSDDTRVEETHTRASSVYSSTAYIRKKTSQLLEAIKPSQPRIDGPVPPKLQELINAFREGAIHQDLQNEILGVAGAPATGENIAMSELPDVLIESKLSRGRKRASWGTQFRILSGRAFKNLYRDPALLTAHYVASVGVALICGFFFQNIQNDIAGFQNRLGVFFFTLALFGFSCLSSLNLFANERILFMRERANGYYSSFTYFSSKILFDILPLRIVPPLVFGGIIYGWIGLVPEVVIFWRFMLTLVLFNLTTASVILLLSIAFASTSVANLVGTLILLFNLLFTGLLINRKTVPALFQWLHTVSFFHAAFEALAVNELRYLQLHEEKYGVNIDVPAAAILSTFGLRAGSFWWPNITLLGIFFGTFTVASYLVLHFYVKEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQZ1</accession>
    <name>A0A2G8SQZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13 14">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_01658</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13 14"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQZ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQZ1"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="16">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="15">
        <location>
            <begin position="195"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL35998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="400" mass="43243" checksum="89231D34AE4C37EC" modified="2018-01-31" version="1">MSVYQATASAPVNIACIKYWGKRDTKLILPTNSSLSVTLDQDHLRSTTTSRADPSFQKDRLWLNGSEDEIKDGGRLATCIKEMKALRKQLEDKDSSLPKISGYFVHISSRNNFPTAAGLASSASGFAALVASLAALYKLPTSQSDLSRIARQGSGSACRSLFGGFVAWQMGELPDGSDSLAVEVAPREHWPDVHALICVVNDEKKGTSSTAGMQRTVDTSPLLQHRIKHVVPERMAAISEAIRARDFDAFARITMQDSNQFHAVALDTEPPIFYMNDVSRAIIALIVEYNRVAVEKTGKLKAAYTYDAGPNAVIYTPKENVKEIVELIIKYFPQAENFKDPFGLFGAAGVQGKVVDGFNGAVSKPFGVGAVKGLIHTRVGDGPRTLGAEEALLGPDGLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRB1</accession>
    <name>A0A2G8SRB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRB1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRB1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013896765" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="364" mass="40064" checksum="A58E9E55CEB9A487" modified="2018-01-31" version="1">MRWIQLASSLTFALSLLAPKAGAAECTNPSVRKEWRTLSTDEKAAWIAAVNCLASLPHDPSLTPTVDRSISNIPAVNESSSYWDDLVYIHMDLNVKIHSTGLFLPWHRWYVAAVESAMKTKCGFTGAAPYWDWSLDSADVENSPLFLDSDPVSGLGGWGDLTNDIEVPDGGFRNLELAYPAPHTLRRNFTLQPWLAFADNVIMTNPGLLANESFTPAEVQKIVNWTPGDFPGMQFSMEHPEGPHGSVHEILGGDLAGYCPADAPANCARGQPTFSANEPIFQMHHAMVDKVWYDWQNANASNFWAYKGGSVQNLTSLQALADYPNGMPPSLHLNSTMPVDGLFDEVTIYDVMNTTGGFLCYVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRI0</accession>
    <name>A0A2G8SRI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRI0"/>
    <dbReference type="OrthoDB" id="2755675at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45929" checksum="CAE7AADF7E65C550" modified="2018-01-31" version="1">MSSLSRQCSERNAATDKFPVELWIEVFRNISHRPTLAHIMQVNGHFCAIAEEQLYHTVSLIGQDHFSKFRFSLESSPHRAPFVQDIRLLRLEVENSSVPNILPSFLTSLRNLRRLELTQVPDFRFTSDTPYCDALSAVQIPHLRRLRIEAGLHPYRFLTFLEAQADFLEELEMTNTRLFKDPPVVDLLAARRFPLLQVLECDTLFLGGHTRIPVPPNLTHLSRSMIFGWELPVLAQRLGTQLVGLKLDSVWLDDRSLADGPPSWSLLNVKAKFPRLRYLQAEAPYIRNYSAIDWFPDKAVERTDTKFPVHPDGAAPQSHSRLTIAWVFDFVIPDDCDAWEQSGTENAVRILTALGGYVERVLLNRASRWISVRLGAGSEVQGERKVIKEEMGNMDRYWAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRU0</accession>
    <name>A0A2G8SRU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRU0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="129" mass="13986" checksum="1B62581AD334BE0D" modified="2018-01-31" version="1">MSTNMFRTSRAQPQDDAATLERWLKRARRSQEDGPEDRVGNGKGVGNGGNMRRYLSHRRFTGVVLIFLRTYSEMMSDACTGCLRAPDPLSSPPSLLSGSSALLGVLAVSCPVVPSSRADLTVTSWPPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS34</accession>
    <name>A0A2G8SS34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_00259</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS34"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS34"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000076">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="193"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="245"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL36570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="313" mass="35018" checksum="966C6B2580EF2D0C" modified="2018-01-31" version="1">MATNFWSSSHYKRWIVDRSTLHQARSDDLQYVDNPEYLGFLNIFFANLISKLGKKLQLRQRVIATATVFFRRFYVKNSYCETDPFIVIAACCYVAAKAEESPVHIKNVVSEARMLFGEEYGIKSFPSDNSKLAEMEFYLVDELECDLTIFHPYRTLMTLCGKEGGGAVPEAEAGEADADDVDGLRYWGTGEGKLELQEGALQMAWFIINDTYRSELCLLYPPHLIAIAAIYLTLVFHAQTRTSIQQSASSSHSHSGSSHPSHSGSPTRRSSRSTSHSQKKQHHQQDVIGFMAGLNVSMSLVATIAQEIISLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSB9</accession>
    <name>A0A2G8SSB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_00292</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 13">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSB9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSB9"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000002">
        <property type="entry name" value="Transcription elongation factor SPT4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="14">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL36603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="124" mass="14168" checksum="551AFF604F34E93C" modified="2018-01-31" version="1">MSSQDRPPASIPSQPRAKQLRACLLCSIIQTPADFRKHGCPNCEELMQMKGYPDRIQSCTTTHFEGVIAVIDPDNSWVARWQRTSKYVKGMYAVRVKGRVPDDVEAELESRNIRYRPRDGTDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSI6</accession>
    <name>A0A2G8SSI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin target of PRMT1 protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSI6"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42307" checksum="9782C0D3A0B8AF77" modified="2018-01-31" version="1">MDIYPDDSPATVLPYDDPIQADETDLIASTSFDPSDSGRSLADRIGHTKVYLLSDASKSRSGKRRRDEDDEDAPKDEEMNEGESLYRENAILLHGTPISHLPTSNIFAYATHFDAHPLGLEWVDDTTCVLVFDSKTDARTAFRFLQKSLAEEPAVDDNSVTAKPIPVPIWPAEDRINAALDKSEGLKGILRMRWARADDIKKKGAKKQSEFYRKYGRDAGKTFEEGPPPPKRRRPQESITDAVTRAQLDEELDNFLAEDEDAPPPSPPSKMRSDYIGTDGRTLLERTSAMRAHSDDNSLASRLTSPLSRRARTRRDGEDVSWEGEEKPVLHDRLSEPGSRYGRGNRDRTRGRRPPRQRATQEDLDAELDAFLAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STZ3</accession>
    <name>A0A2G8STZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.265</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_00942</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.265" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STZ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8STZ3"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Brix" evidence="18">
        <location>
            <begin position="676"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="879"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL37249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="910" mass="102774" checksum="718EF74466ADE5D2" modified="2018-01-31" version="1">MSQHRLSPIATHPSSNAIPGEKSNALPDSIPEESAAAGKEVKGEEEKPATRSGWLASLKLDMAKTEWDILVASTCLKLLLFPAYRSTDFEVHRNWLAITHSLPISKWYYDTTSEWTLDYPPFFAYFEKFLSIPAYLVDPRIVDLKNLNYDSWSVIAYQRTTVIVTELVLGAAVLKFIRGAENPTMQRIISASLFLHPGFLIVDHIHFQYNGFMFGILLWSLLMARNDRKLASGFLFAVLLNFKHIYLYLAPAYFIYLLRSYCLSPSFTLLPGRFLSLANAVILTFLVSLGPFLLMGQLPQLLSRLFPFTRGLNHAYWAPNIWALVTAADRVLLKVVSAGRLAGFAVNESGVSSTSRGLVGDTVFAVLPTVKPIHTFAITVAFQTIYMGKLWTNTSYKSFVTALTLCGFTSYMFGWHVHEKAILLVLVPLSLLAAENNEYFRTFEIASVAGIFSLFPLLFTPAETLIKIVYSVLWVIFVLRPIHRQVYQFPASLPFVAIDFLERLYLACFPFLQVFVMVFPLLTNRSAPVDATSDYDDGTESGGSALEFLPLMTTSVYCAVGLVWAFAPIRSARTSSLSRLCPGHLPLRYCNNRVMIRRQARERRQYIYAKSLEAQERQTYVRKQQIKDALASGKALPTELRKDAGALGRDLAFDEAQSEPSSHIDNEYSRAGILDPKIVVTTSRDPSSKLLQFAKEMRLVFPNSHRINRGNYVVKELSEACRANDVSDLVILHEHRGVPDAMIVSHFPHGPTVYFTLHNVQLRHDIASYKSSTVSEQYPHLIFENFSSKLGERMRDVLKYLFPVPKEDSKRVMTFSNEDDFISFRHHVFMKIPPKQVQLAEVGPRFEMKPYEIRQGTIEQTEAEREWVLAYYSRTAKKRSLLSGPAPPPSAAAAAEDNPGTNPKKRARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUS3</accession>
    <name>A0A2G8SUS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUS3"/>
    <dbReference type="OrthoDB" id="2758506at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="510" mass="54591" checksum="EB8BFC8A31F3BB9C" modified="2018-01-31" version="1">MDFNAMIQRTTHLEEYAVPAGVLFVFLLLIHQRHRFTLATATNVNGERSGKGVRPPGRIQRAASAAVAEAVVDFDGDETAGSVESEGAIEDPPSPSDSLSSNAGDAVVGYSNGPATRAGSLYSIPEHDAQARDNHRCSPDAPTSRAVLHRDTPAEGCRSLRSGSRSSTAASTALQGPTIRVVSASEVGMASRMPRAPSATSASTGRASSLSVEFLLPKVESDDDDYVLNKTVPISTPLPPKCASTPRTPSKARGGRSFSQDLDNLASDDVAPLSSPLPPKQSSARVSSASTSRNNSINSSSSLSRGSSSVAGRASAGARSCTAMPSSASTSRAISHMSHDATPPPSSFASFASATVSRAQSPDIWGSMSRMSSLSPSPSEVTEQWVRKVSCRTLPSADDAGDRAEHAIITSWFESSSDVSDALIDCPPNLRDHPDLQIGDLFYHSTPTDYQLWIWEVDEDDKLRWVRVKFMSVRNGLYLTLTPEERRPSWVSEKYARARKRQLHRQGYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV82</accession>
    <name>A0A2G8SV82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV82"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="107" mass="11431" checksum="DFE0300FE8EE7CBA" modified="2018-01-31" version="1">MNPLTEVCQFVPNNGCFSASASAFASPSHPVLNPYPSKNATRTPPATYTTAASSDTNVGSHPMTRASGRSAARRPTPTTSSPPRKPRHVQRRQDAEDEHLGEGAEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLK3</accession>
    <name>A0A2G8RLK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_15089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLK3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLK3"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="525"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="577"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="686"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="277"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="805"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="899"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="932"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="963"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="998"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1024"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1034"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1092"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL22401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1114" mass="122542" checksum="9140A24A8F245D82" modified="2018-01-31" version="1">MNTKNISLLGEESEDDFDWEEVQVAQASALEDIQPSSSTPPTPSVHDYYGDLQDQQEVLSERPHLEITIKTLGKRKDPKKNERAVQLAAERAVRLDCHKIHTVALLMNAKVRNQWINDPLLHARLMSLTPLAHQNAFAMIHKSRVPEAAKRGRLFESAITRLADWWASSFKVVPSGHLRSRTFHDVQRSLPKPKPTPPPDPKGKGKGRAVEASDEEEDDEERYGVEGERIRSAKSLMKHALMWRGSRDTSAQLFTALCRALGIPARLVVSLQSVPWQASVGKPKPSAKKTKKKAVGSETDAKGKGRAKPGASNGQDEDEDDDMEAVDIPDSPAGGGSRGRSPNRANGPPAEGTNDAPIGKGKGKQKATPVIRLRKSKQNWGAPAEPARPRRERTPDPTTTAPVFWTEVFSRADARWIPVDPVRVIINKRKAFDPTPNPGATTKPDRRRPVRVENRMVYVLAFEEDGFARDVTPRYAREFGAKVAKVQQGGKGRREWWERICRMVTRPYRLQRDDLEDEELQANQMTEAMPTTMVGFKDHPLYVLERHLKRDEVVDPLVELGKFRGEPVYPRGNVLQLKTAENWMRQGRTVISGAQPLKWVKQRAVTVNKKRAIEMALADQRDRASTSKSASSAKGLDETGVLAVDVDSGNVENGEGFAAEEGIMQGLYAEHQTELYKPPPVVDGKVPKNDFGNLDLYVPSMLPAGAAHVPFKGTAKIARQLGFDFAEAVTGFEFKKRRAFPVVTGIVIAAENESVLLEAYWEAEQDAETKRQAKRQEQVLKRWTKLVQGLRIRQRLIEQYADRNVPTAGASSSTSGTAKADGHARDSGAVDNQPADEAQGSQELIAGGFLVGVDDVVQPYALPRNLHEIIEHASTGHTALGELQTTNPGILTAPVADAAEEQDADDVDVSEQGREPLSLLDVDDKLEVEGSGSEDDDDAMEEVVVDAPPLARTPKTMQELAEEAARRNGDANHRADDEEELVIAAPPLATGEKAAANGRKTSASRSRTKSGTSTPRPNTRGKSKASAASTSKAAPRRTRKRTRSQVEHSDSDREEEGGGEANPPGSTVKKPRTRAAPPPAEPSTRVLRTRKPKDADKVREEKEMEAAYRRAIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLR1</accession>
    <name>A0A2G8RLR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_15144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLR1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLR1"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="11">
        <location>
            <begin position="55"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL22456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="468" mass="50631" checksum="1D0BCB846C62C9EE" modified="2018-01-31" version="1">MHPPADRAGALHPASRKTATTSARTGTDHRDAYGTAWTNMDDADELLMLYDGPTVVLDDRDLPSIAKFMKSPQCKRVFVMLGAGVSTAAGIPDFRSPRTGLYANLAKLNLPYPRALFELKYFRFNPVPFFTLTHELYPGRFRPTLTHTFIKLLADSGLLHTCFTQNIDTLERQAGVPLDRLVEAHGSFASQHCIDCKKEYDSEKMRLAIEKAEVVRCDDESCAGLVKPDVVFFGESLPELLSQSIPKISSADLLFVIGTSLTIQPFAKLASMAPETCPRVLINLDFAGDIGMRADDVLLLGKCDGIVRDLCLELGWADALEREWAKTELPSSRPSTGILSSKDSSHNEGLRAGAAQDALLPPHEQVETGRLGAEAGDANGTSTPTAAEWQEKLGATESLTERLRVALESSEKIVPLMEEAAATFAARTLSAEELLLATNTGGDSGDSTPVDEAPYILGGTAIPVEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMB4</accession>
    <name>A0A2G8RMB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_15332</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMB4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMB4"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL22641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="483" mass="54688" checksum="B7CB7832496D4AEA" modified="2018-01-31" version="1">MLIPQELPYQRVLLDSLVVAVTFAITSFFIRTLRIKRAGERLPPGPPGHWLFGHVLPRSHAAYHYSELGKSYGPVYTLRYGSKYVCVITGHRAANDIMVKQSHKLADRPRYIVAGEILSKGMRILATRAGDRLRRLRGSLHAILQPQASIAYVPMQMKHAQNYVLDILEAPEKHLTHAKRRINKGTARLGDALRPGAYLIESYPWLRYVPGMTSKLEMWHQEELNLYRGQVEAVKQRLAKNEVQPCFTTYLLEHQEESGLSDDELAYLAGSMFGAGSDTTSGVLGFFVMAAAKYPDTQRRVQAQLDAVIGQDRLPTFTDQDRLPEVWAYIEELFRWRPVAPAGISHAATEDVFWGDYVIPAGTEVVGCHWAIARDPDVFPDGDTFNPGRWLDDKGQMRTDLRFFNWGFGRRICPGQHLADRSLFITIALTLWAFDMSEDPAHPINTMAIKDGGLAHSEQFAVRFRPRVSELREKIASYQPEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RND3</accession>
    <name>A0A2G8RND3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RND3"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="395" mass="43293" checksum="7A7FA5DD86EC6E14" modified="2018-01-31" version="1">MNPSASSFVYTATDPCSSTSTVSHCASAQSYYPFVEYTPSVYEDSSSESSARDWTIERIGCSDTYRALFEAFFKAEAASTISMQSPPSYDPQSSFVHHPTEAAQAHAQHLDVLWSYPCASTSSQSNIPPVFNLAPRETAASPASLDLMYPPSDDDYVPEECYSVAGMSQCSHSAAQPWFPPSPSSSPEPWPETSTCVVTVSPQRSVPAHTRHSPASLALESSLPDPVSQDLIYPSTYYRYGLSDDYSTYLRVPNRRAPAAAQPVAAHPPLPIPPLPHCRPDLPASNAWQCPHCPYVQRNRRSPDLKRHIKTHTRGADGADWVCCGVPVLNAIELGVPATIVREARVFELDGVLMIGGCRKAFSRRDALSRHLQRERGKCFGDALSLHQRGNRESC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNI4</accession>
    <name>A0A2G8RNI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNI4"/>
    <dbReference type="OrthoDB" id="2755153at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="386" mass="42134" checksum="73A0E38219511CB9" modified="2018-01-31" version="1">MVRRALVRKSRNRIVRLYAESLEQQVGAAVALKTRFFSEAEDRGSESPAVLEERRGSVEAFLAALQARTDAIERELEFKLKREKEQARAQEFEKEAAASPSENPAPELPVAPVPTAPNPAPTPAPAPNPSDSEPPAYPILDVPHPPCACTADSSDTRPEPRGPPGRCTALRVRDGERCTWTCRSGQRFCVIHCVAHGTVVVSHKVKEGMLEAHRMRLVRRAREAKRASGTGSTGEAEAEGAAGDRDKVQRMDVKVYIDQLEEMIGVVEEHQRLFSCRSPESHATVLHDLKQRRTSAALLLGRLSGRTDAARTAENQGQAETWAAEFLAEVKHKDALERRKAVEDIVTGAIVGGATAWFGVPWARSAVAGVVSPIVVRKARDASEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP62</accession>
    <name>A0A2G8RP62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP62"/>
    <dbReference type="OrthoDB" id="2758490at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="139" mass="15272" checksum="94DC1E077CB920F6" modified="2018-01-31" version="1">MSETACAFYYLDNRSIYFMVLTGMNVLMMILSRIQDQSGPSLENVASIMINPMTAVLIAHFLFDLRRSDRTANVPSSPSAIPSLNIAGDIQEDHGTLPAFIASMGSRLDTGLHFVDVLDAEEDMAPRHPPNERLSPEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ63</accession>
    <name>A0A2G8RQ63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ63"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ63"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="216" mass="25065" checksum="C9ABAADEBCE50A49" modified="2018-01-31" version="1">MGRRPARCYRYCKNKPYPKSRYNRGVPDPKIRIFDLGRKRASVDEFPFCCHLVSDEYEQLSSEALEAARICANKYVTKTSGKDSFHLRVRVHPFHVLRINKMLSCAGADRLQTGMRGAWGKPYGTVARVDIGQIILSIRTKDQNASVVQEALRRARYKFPGRQKIIVSRKWGFTNVNREDYLKLKEDKRVLQDGAYVQYIRPRGNLENNLRAQLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQF3</accession>
    <name>A0A2G8RQF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sacsin/Nov domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RQF3"/>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1454"/>
            <end position="1467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1758" mass="196555" checksum="6AE25E002CD847E7" modified="2018-01-31" version="1">MASARDALWNSGYDESVEVNQRALIDKVLARYSGEFTVFRELLQNSDDASATAVEIHFETKEYVERKNANVNGSGDTSAVPEAKERLPDLKTTVVHQWTFKNNGIVFRDEDWSRLKKIAEGNPDEEKIGAFGVGFYSLFSVTEEPWVFSGDQWMNFYWKDKKDQLFARRGARKDVTNDPWTTFQMELREPATIPQPFDFTRFLASSITFMRHLLDVSVFLDDKRLSRFTKSPGSPQTLSLPKGLRASSPLSTMTVNGLQVTPLLIKAEVMQWVYMAGSEKPQPKKEPPKPAVGGGGGGFFSSLFSSFTSSNQPHRTATPAAPAPPPVPKVDPKTVVESSVVLSIFTADVGVKLDQKMISELNRSTKKNPPTRMKYELIYTGKDAYDASKREDEKQGRSTGSVFQGLRADLDGTGQAKVFIGHATGQTTGLGGHMSARFIPTVERESIDLVDRNVAVWNKELLYVGGFLSRAAYEIEMAHIRQLWNEALQTARAISPDQSVDPEVQAQLRGRAIHALKFFTFHSSTPSAVVSSSLEEAFFACSATKLMFLASKTPFPIMSTTGVWDAGDVRYPDPVFTGFVKNLPVVPDEILVQASSMIDTLRTRGLIKDITFVDVLEELRNRPLAETEMIACFKWWIDMYQEGTTENIDYVRTQLLNAALLSIPGSDNKAGQVIPLSVIQSFLNSRSTGALIPTDGPLPPHLLPVAISRHFDPTSLITAFAWRELSIIEWLRHIANPSAPHDTEHDLHLSPQWAERVLQVLARASQSLPAGRQDEVANILREHACIPTSAGLKKPEEAYFQNAHVFHDLPIVTLPSGAVVKGPLEKLLQAIGVRKHVDLQIVFNRMIKTGDWTIADLIKYLVAVQTTLTPVEFERLTMTSAFPGERREDEKLPENGKPPRHKASDLYEPLDVFRELKLPVIDWGTHPKWRSSSEEAKFLFKLGLRRYPPLPELIGLAASNDEAVRTAALKYFFDNYTTRYSDYDPDSFSNVAFIPAVKGNTKTLARPHEVFSAPEWAALGFMAIDSSLRGQALMHLKIPEHPPGPRLVNLLKAMPPSTEDIARLWFTTLASRVVAFSANELHVLSQLAFVPVKATNGAMCHRPPTQCYFKGDSQAQFHSKLFTFVDFGTTANTFLSACGVKHEPSVEEIAKILLDNPRQFYDLAEGREHYLTELRNIAVNGRLVSSGTMARMKRTAILLGIRRVRKSQPATTKKQNETAGELDEEDWDYQYDLLTPDKVVIADEQNAYQLFGDTIFSAPQEDLLENFYTELGCRRLNTLVREQHNSSTEVIGSRKAAETRALILERLPLFLHEHTHTKTSVSYSWLNNDKHFIVKTFGKLTVTKTLVFDGKVVSKSHDASAVARRQGRGPIELWLAGNDQVDMYEVSTSMCRFLFESPKANDALLFMTILSTDLRALRRRGYNVDRILRQQKADRLAAEEAARTKAGALVSHPGASSSSDTLVSQASKPDGKMGSAPPPKDSIVDHIPPILPEKSALKPRPVSQMLNMFRRKGDDSASTLGDAPPVPSKERTSGETQLPLLPPPRPDRPRTPNPHATPRSSIASNIDLAIRACKEERSQTLSNRQHMQMVKESLNEGYCDISGHPTDMIMTGEMGGIKIYVAKANSRYADCGQDVPDARTLMQQKGESLARFIYTVRPLREVYTLPTTSLHIFYDRAGELIAFNRNASLFLNLRYFEQWHDAEVQEGKMINAYTSWYFTLAHEIAHNLVAAHNSEHEFYFSSICETYLPAFMKLVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSU7</accession>
    <name>A0A2G8RSU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSU7"/>
    <dbReference type="OrthoDB" id="3263038at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="576" mass="61279" checksum="627F835FC840FAC3" modified="2018-01-31" version="1">MSVSLADFVAGVDKLDATGKNFVLFRDQFQIAVTQKEAWDHFSGTSVRPAPAIPATPTALEIASIAAWDKKENLALYLLNLKIAPAVFTKHKRKGNVAAIWASICLDMGAKSLLQRANLRRDFTNMRYTPGADLHAEVDRLRLAYENLITLEVKISDAEYASTIIAFLPHDLSAFVAQLSAQIRAHDLMTPATTTAAPIDPDKPPIDPEVMLTLVLEEWERRQGERKTTKGKDRDPGLAAAVLQARSPSVVVAPDDESNNLPQNQNPPPPPPANPAAAPAANTVARPYGTYNLDDIAGAWSALAPQLLDSDLDDDDVSVCDPWSDDAASAYSDLTEDLDAADSLPDLVPDAPAFAFACPAHPSPTTAAVDCPNAVSLEGEEMLSLAKLTSSVRPESRDVCLPAVDDLAAVVNSPPGLSVPVRIAAPPNESLAIQDLPRDVCPPPGDVLTAGFNALPAVSTPAIAASPVDLPDKLNMPALVDSASDRLPGPFKLPIVSARDITRGSAAASLKPPFLVDVGGAFARISASPHPLRSASEATAPFAHTDFFTVFDTSPTSRARLDRIRRYADVYDTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT34</accession>
    <name>A0A2G8RT34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT34"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT34"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="421" mass="45080" checksum="C94017F0F3C6BFD7" modified="2018-01-31" version="1">MGLPTAAAPSVRLPPIRQIHEQPIEALANDVEYLHGIYNPPVRGARRVDRKALKDISHPGAHDDENALLETLRTDEFERAYAVRWLTALVFRACLLTSSPEDDGTPFDGEEKVDALIRSATSLIAVCAGTTAARTLTRRYAFFAPSLNTDVEVSLTDVPISADSDYPSVGTQTWGSACLLAEMLVEEPEKFGLPAGPQRAAGHPDSGSDSEVCILELGAGTGLVSLAVAKLLSLSMRGASATVVASDYHPAVLGNLEQNIRANFPPGALAAIHGLSLSAHALDWSTYTNAPPTGLPVESTCGVPAPFDRPFDVIFGADVVYEPSHAIWIRDTVAALLPRCQPHPILAQSESRAPRFHLVMPLRPTHTSESRMVEEAFPPVGTGGARSELALCVLEKETIVCEAEDARGAEVEYAHYVIGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT93</accession>
    <name>A0A2G8RT93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT93"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT93"/>
    <dbReference type="OrthoDB" id="2753952at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="709" mass="80247" checksum="8D0DFCDC29777455" modified="2018-01-31" version="1">MRSRSHRLSRRANAGAFPTLPPILKLHLDVVALICDHLHPTDVLSLSRTCKEIHRFLHVKPSRWAWRAAFRNVEGLPACPKWLPEPQYATLCFEEFCTRCLATDPASTSSLWPFGVRYCLPCRNAMLTAKPFKNFPDVATLGLKLRATELFPGLLTGPALSKKVLSFHVPEVEKLRKDVTKFIGNGDQALATTSIRTLLDEKTKNTKERLEFALECKRWMYLWRREQERIAHELRLKRRQDVFQKLELLGYSNEVRDLGLHQQGLTGEVLAFVQQARALNDREWNMIRPVFVTFMEDRRVLGGRVTYIRLLRSRLRLLQLKLFAYLHEGDRKDKRVGGARMFPTVLDLLDVKDAAYLVSLPEGALLMPHFWPAHLPGLIDAWERGRGEVLLSLLHKLEDSSSSTGIFAHGPSVHGTPTSVTTRSVAATSSSPLSHPAALFWCNACMSLVSGVIAFSHACCYGRADHDHAEIFTDLTPLVNGRFSQVVTTSDSNHSLFEKTVVAFSDGILPWSPEHLHGCVPVVRSILRACGVELQDLPREIQKVASSRFACTACSQVGKSVLAMGWLRAVSHAFEVHEGQEGSWVRLPHKLEEKAKHVEYTSVKIFTAELDAHTRWECSRCAWDVPQAGLAYTWPQLVNHFNVYHPMTLLGPMWYRPSEDTAPFMYPAVHFVTRGAEGEIDDDIFQAFPRRHLFTPYKLAADTWVQLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTI0</accession>
    <name>A0A2G8RTI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTI0"/>
    <dbReference type="OrthoDB" id="2797179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="299" mass="32223" checksum="6F37B4B8F0D1222A" modified="2018-01-31" version="1">MSSTSASNPIEEILSGLALPGFSAPYTGRTPPFLVPPSTDGILAILCPTDAQVFRSALAGIPLIADAPPLLTQFLTSSADTPPFLASLHAKLLELGWAVETEHAKVTREDPVACYALFMRTGGILGRLGCIDDIRYAARAALRFSQEELDDEMARAILNGTPTWETFKPLVSYRLACAVTLTPLISLGPPPAEVVRGYAWTWRTCPNCVVHIQHGPGDACGAPCREAPWFVVFWKELVATLRASPDPDAVLGVQHLSQALQGAMVCPTCSRVAFEHLRCFQGLLIVEAAKRIAEVSFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTS9</accession>
    <name>A0A2G8RTS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTS9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="103" mass="10969" checksum="1792E16C571F7EE6" modified="2018-01-31" version="1">MPTRELPSGPQGKGSARGEYSSRRSRSPSRGSRSTSTSTNVCACLACPALGTILRPHRKGTTRHPLLLPLGVLPVEMRLEPPRTGLGLPRAKARTACRTRGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUI7</accession>
    <name>A0A2G8RUI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUI7"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="402"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="764" mass="83789" checksum="A16F650CFFD858A2" modified="2018-01-31" version="1">MSQSEEMPPPSWRSLASAASRSIKGYITQQRELKQAYPSSRSIAPPGAEAAKRQSWSQWAGQKLRRGSQAEYDASGDRLSLFPGWAVRRYREPPKGSADDTPFDIDVFVSGYASKLTGVGFNTRAGRTFLRLAKSFAALPKLPNTGMSKSTEDLLTGTSLPPLPDEITEESEMQLLEEKLRRLQQDARSVESTSLPLDAQSISSNDSSTSRPSSIAPLYNPGTVGPLTSSSIDAGTPTELRRWHANLEERLHPFWSSVLSNRIVRVSLYAADPSLYDSDDRRTDESSSSQGSVAPEKRPIDTREVITAVDGSFQLKFSVPWTTMCVHPAALQIAFGGTDLEQEVFVVAELLAPPSPGPATLAAQYPYAQYQPRQARPAVPPNPVSTVSTATAISVPLTFSSVRVISDIDDTVKLSGILTGARAVFRNVFVKDLRESVIRGMGEWYTGMWKRGVRFHYVSNGPFELLPVVNAFLQLSQLPPGSVRLRSYGGRSLFNGLLSAPAMRKRSAVVDVLNHFPDARFFLVGDSGEQDLELYAEIGRERPDQILAIFIRDASVRENDVMRPLDDPTGADAARWDAFQSGAVPPGSATSQTNGGFAPSASKRASSRYASRSMSEATPGSPPAIPSKATRSFSGLDLSALSRNSSGSSSPNYFSSTPRSYSPITEEPPWQPTMTTATDDKSWPPPGFSKPPPGSQAERRESRSSSQTPSPTDAESERKRWDLQTRVWKARLDVPPQIPLRMFREPEECVEVNQILDRLQLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUM5</accession>
    <name>A0A2G8RUM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUM5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUM5"/>
    <dbReference type="OrthoDB" id="2754780at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="592" mass="67325" checksum="EA9991CE9BA34414" modified="2018-01-31" version="1">MDNIYATQEIESRLSNDWRTSNLAQEAGEAARLAKQHAKFADARKFVLHDIDVSLQAILDLKTRLNTLTAVGRLSDELIAKLLITFVDELYYSQSALRDYACFRRHKPPRWLKLTHVCRRWRNIALRTTRLWSHVYLSRSDAFAVFVERSKATPLDIDVRDANFYGSIRGGVSILDLIPPVSSRIRFLSVDGQITTVQAFCRKLTQPLDQLEKLVLASHLPWFGLSGPPPAVPFVAGEGLTPRLSHLELDRIPFRWTDPAFGSSLTTLKVISPAWSPTFWDPNQPDIGTTADLLDVLERIAPRLKALYLDGSIPTPDNQNLRPLCAARSLSFPSLRSLYLSGPTYDCADLLSHFSMNQEAGIHLIGTGNKGMEDLVRMFCAHLTRRPLFAVRWGSSWGSYNIDIYGWQTTDTSEDWDHAPVRLAFSQIYGDGEEDYMQTFIREISPLFSHVESLNVYNGIFYKLIWSDLFSLMPRLRTLVFDTDPPFDLFDALLDVHTLPSGQSLVPLPELRSVHFNEVTLRYLRPGDDKAEEPVFIDDLLTWVALRVQHGVPLETLELRNCQHSEEKDFEGLRRIVPNVIWDGSGMSLRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV40</accession>
    <name>A0A2G8RV40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV40"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV40"/>
    <dbReference type="OrthoDB" id="5599163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="694"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1191" mass="131610" checksum="A0AC29EBEB9B2281" modified="2018-01-31" version="1">MFSLIKRIVKIEYIGEDGVSLFSRRDLNLHIAAMATTTINSVKDFNVYSHKFRDIASFLVSGRQLRTDDRDHLFLHGLPPLMRTSVLERLRITVPVTRYPRDPYSIAQVTEAVHHTLEAATLGGSTTTAANPVSMQVPQVKSELTQAVESLATIAATFMQAQKTPVANHSVAPLFHQRPLPPHMVPPSNPAVPPPPRTCIYCSDVSHSIRACLLVDSDLAAGLVRRNERNQVTLPNGTFVPNAVTGATLRERIQKYHQLYPEVRTQAVPQLFFAPVHHTATAEPTYALATLSTPPPMSRDPGMDLVQQIEVRRQELYALEQQFAAQQVPRTAAMANTAEARAECARRRSVRFDSPPVRAPTPPPAAHIEELPNDSADQPVPPLAPAIAQPAATSSTPSTTAPGTAPSTSLEHPFANARDATYAPLSQRNYGFPPPRAQLVSRKPDPAYRARPPVYDPRHVANVLHRCLEQPIMVTKEELLSMSPEFCASTRELCTTRKVPTEPVLSQDEVALPFVGDSDEQPADQSSRKHDALLAALPATFEAAQGASSAYPPPGMLIVPDPVDMYLKSLPPDAERKPVKVSVESAAIRAIPGVFSSGTEISCIHDDGCSIVSMSEGVCHHLGLSYDPRVILQMQSANGACDYSLGLARNVPVRFGTITVYLQFHVIRSPAYDILLSRPFDLLTSSIIHTKPDGSQTITLHDPNSDTVTTIPTAPRRPPDSLLPKPPLYPIPIFSIHSHVLGASDPTIPRSPSSSPLSPSIAYPVNPIHHVYDSSPSLCHADNGIHSSAPTYLFSKKKYKPVAKKVKPVLAPLPDNFRIHCNIVGDPLASMKPLSPHPPDFIPTGRYTEERKQIVDDLHGDFLGPEERKLLHQLYMQHEQAFAWTDSERGSFREDFFPPVQIPVVPHTPWVQRNIPIPPGLYDEVCRIIRVKDEAGVYEPSNSAYRSRWFWVLKKDGKSLRIVHSLKPLNAVTIAQSGVPPFTEQITDHFAGRACGGVLDLYVGYDERKIAESSRDLTTFQTPFGARRLVTLPMGWTNSVPIFHEDVCHILQPEIPHITIPYIDNVPTRGPKTRYELPNGGFETIPENPGIRRFVWEHLNNMNRVVQCIEYVGATFSGPKSILIAGEFTAIGHRCTYTGRVPEPSNYNKIVNWGPCRNLSDDRAFLGTVGVARAFIRNFPSKKKRKKNQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVC2</accession>
    <name>A0A2G8RVC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVC2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="184" mass="20694" checksum="58FF256D5D46F516" modified="2018-01-31" version="1">MCTLELTQCVDAVCLSATNLANLYASLKRCTSLQSFEIQCNVARHPDYVTRGTPFVFLDMLAEMLSESPSSSTPGSCPGLLRLRPRVWLPERDTLKVAWLQTPVPIPDGWAEACEQLARALEDRSRHSNSLLRRLEVTVRMEQWTDEIYMSAAHWEMVVAQEPVLPSYFERAAAAGVQLRVVIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVZ2</accession>
    <name>A0A2G8RVZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVZ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVZ2"/>
    <dbReference type="OrthoDB" id="2685413at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="592" mass="65761" checksum="BD3FF5DE0F9DFCBC" modified="2018-01-31" version="1">MHHRAHPSLSSHSSSSSLSPIVRSANVFNPKILDASIRDVTSCLSDDQKADVLLSAMGHLELGRERGSVLPVDIQIVPAEGGEGALDASKGQTGGWTARPFPTPAFPADILAALELQPDNPEASALMTQHVAAPGQPLVQPHTTPGFSTEIWREIALWLPPRDLKSLLHVPHVLSRIASELLFQRIDLQLASEKRESQRSADILTRIITDTSFASHVKTLRVFVPGRETFPITFQTGMLSNALPKLTNLKHVHCAMRWKDMYSFLRILESISHRLTGLSLMPADGTGELRFPRFKHIMQFSLHSTGGAPTQVYDFLLQNKSSVRYLSLHNPNWSFPAEAVSIRSLTHLDFQGIFPGDSRAFADILANGHQLESLRLECHLECTASTQFREHPTALPFLHHFAFSLIGYRVNDHDLFPAISEFLKGRSALRTLQLTVPSADWALKRLGYDATVWGVLPSLTSLRSLTATLPKDVAAPVAMWLVPRGVQALTLQALAPVNTLEFVSQLRAGMPPQLRYIGLLRFHVEDAQAVIEQGFPMVSVARIDDEYFTVSKAAGQVQLEEWPKGRTLFNARDWLDCYGCLEAEWRDPTQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW98</accession>
    <name>A0A2G8RW98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_11504</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW98"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW98"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="17">
        <location>
            <begin position="254"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="554"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL25754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="620" mass="71524" checksum="A019685711BEE8C6" modified="2018-01-31" version="1">MSDAERNYEIYDKEMLAIIRALQAWRHYLEGLPSVFEIQSDHKNLEYWKTAQNLTRRQARWALYLSRFEFVILHKPGTSNGRADALSRRHDHQTDDADDNLDRVLLQPDRFRVLAAKRGHMSVVPEKALLRRIRECGECEQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGRVYVPKDDALRAEIVRIHHDLPPAGHPGQAKTVELVTRNYWWPGMVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNALQLIADRHGKIIHLIPCTEEIDAEGTADNFIREWFRLHGLPRKIISDRGPQFSSKLFRAVLKGLGIESAMSTAYHPQTDGQSERWNQEIEAYLRMYCSRHRDDWVKWLPIAEFAFNSHVHSATGYSPFYLMYGFEPQFHIPMLSTAVPSADERREELRQAREDATSALTLAAERMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKHKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESRRYGRWKKLQYLVHWMGWGPEHDSWEDAADLANAPKVVQKFHSTHPDAPSPLNTKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXF9</accession>
    <name>A0A2G8RXF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXF9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXF9"/>
    <dbReference type="OrthoDB" id="3046414at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="434" mass="49081" checksum="B0E741DA6BD9DCFF" modified="2018-01-31" version="1">MDPSGLPGVLGGALRPAYNARQAQGLTKTLLSPFELLLLTPRPEAIDDICFCWTPEVLLKIRQLSSAAFYAIEAYFCRQMNIHHHMRRWVPNVQEFFHQLTLCDGLISGSEALSFLDRRRFIGHDLDIYLPPHGVLAMGRFLKSCGYVYQAPSGTHLMFDAAAMLLTSRNSLNGRKPGASSAKRPTHKQRKTQQRPGYVVPTFDFVRPMPPGLSYSYGTHVQLMAVPCDPMEFIINNFHSTGVMNVLTATHAISVFPNTTFNYEQTCVCQDLSGYPDWTAPWMPKYRERGFNVLFSKNSIPQRAELVTWKRRVGDTMTWIFPYRRMGEYPYCLNGKPPILDSYSRYTFEVLDVSYGVTPTGAALRVGPRSAYRRVPFSAAWILNPDHPRLCYTYFSSDLSIAFSELYQVSSDEEFTDSDSSASADEEGDTEEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY62</accession>
    <name>A0A2G8RY62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY62"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="367"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="479" mass="48728" checksum="1E76072894A45A4F" modified="2018-01-31" version="1">MPAQTHATVVPVQVQGDSPTPLPLPLHLLAQSQSQSQSQSPGAHAHAYSHSPSLQHLTGEVLATARLLQQQIRTLECLAHATEEREATLAQQRAKLQELLRLVTHMETAEVRATASLRDTLARVQAGRDRGAGALAALSLSASPGMSPWASPPAAARGGGGGCGGGDGGGGGGGSGGGEGEADPANNLDPESASVSPKKGPGAEECEGGHDGGDQRGGQPGDGEGEGEGTDGTRKHKQASVSFGGHRDGEAEAEDASQPLPQFSSLRVKTEDEEPQRAQIQGAPQEEEVGAPLPQASPVFSPGMGTSEPKVVDRDHGGEKGRARAKSEHGAGQDHGSNSKESKVAGDGERGVSNIAASRQLDRPRMSASGGAPSPQPGSPASSRQGNEPGDVSKAATGSDGSWRARKRMPGRNGKEQTKGGVAEAESGQEGAKGRGGQGDSDGQARGHQKRGGQRTPSPKKAQVPGDRMQPSPPKKAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYB6</accession>
    <name>A0A2G8RYB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12269</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RYB6"/>
    <dbReference type="OrthoDB" id="2562493at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1058"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1122"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1251"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1297" mass="138437" checksum="481E7596D1FA71DD" modified="2018-01-31" version="1">MTAEHSCAKSIASLAAPGRSARTTRSTASKQLSSISSESRDDMQITTPTINGPKTPSTDGGAMVSKNILTPFYMQITTPAIDGPKTPSTTDGGVMVSENASADSLTAATSPTTAAPTLPVNGSPTMPVSPGSQVSATPTITINSTAAVKVSAPTNDTIAAAVVTATAVSPGAATTSTDVRSTPTVVTDSIASTPTTGVHGATTAHVNTTATPTITTNFVGAGVTATQSMATTPTTAPALAGMPSTGAPAITPALTTATTATTAAVPFITSPGTQLAAPSTATVPVGIASTAAPTTAPALTTTTGPTTAAEPMAAAAPTSAATTAGTAPDTAGRFVDDAAISAAFSASGPAATQLATKLHDVRAVAATRDFYLALGQDTFQGITWIKAGGGSHIVVDRQLGLANAEDRAAHAAQPELNPAPPTPDLARLYIIGNISSERCFMKCDGNVGAVNPTASFQRTLANNTMVCALVKPPDEYPFLVDEFNRGINTLKAIIGADVDEPWDGVRFKEIKEEHVRLRHKVFRPKADGDPRTEHLPAEYRTASWPVNHDAEKERESLVHTHYAHPLEAFDVGGELMHPSLYVNLNGATVLVGISVTHFTFTKKNTVCLDISYLRVLIPGSPRYRSTSKRTAMEMSDPLSHASVNAYAIAPDDICCDLWVPNTFIPTLSTFLTYHGSYYDPWYSLRFATSAGGWKPKERDLSWLTVGDHPLRVWITGSLAGLNIQLDHNGSPSASVKVDLFTDVDRTAAARIFDRGRFSSLEQHLPPTPPVADLSLDIHGFPDTWFPPCYDASSGLTPPNLLPALNPGSVGTGDIIACECTVIRLDHTVTRRQTNGPRCISLPTVLRRILFGPVAFRRLPSPETRLKRSEGPCWTGSRELQQLLIRRRTTSRGFVASECGEECLCLWQARYGRSDSEMAMVENWSALAASNGTATASVAGGNSVPFKYLLGPILVGVLLNCFVYGIVFLHYVQYMLGYNRDSWSLRAIVNWCFLVDSAHCIAALWLLWDISVRHFADTDFVSLTTWPIASIPLFIGATAAPTQHLFAWRIKKFTHGWPLFIFISVLSIASASLGVATAVKSLRQERGLSADSLIPTTDAWLALAMTCDAILAYVAVISNDYSYFLVLTLGPQSILLYMHLMKSKTGFSNTDTIIGRLTRSSVETTVLSALFCVLYLLTMSIVPHTNFHILFSMPLGRIYTGTLLSTLNSRTTLREELYSGASMVGDRLAERLRRIPKEIGIAVEQDVQMDPLGDADLKLPDHDDHEDTPHGVDSDVDDCSSPTRDRKVSADDLEYQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYE3</accession>
    <name>A0A2G8RYE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYE3"/>
    <dbReference type="OrthoDB" id="2798231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000003">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000026">
        <property type="entry name" value="Transposon Ty3-G Gag-Pol polyprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="112"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38773" checksum="19596DBED7E33AB9" modified="2018-01-31" version="1">MEIAIEQNKAKKEQTFEEMVPEQYRDFRDVFDEATFSTLPERRPYDHAIELTEDAKPYCGKLYPMTRDEQQALDAFLEENLSTGRIRQSKSPWGAPFFFVKKKIGKLRPVHDIRWGYNNIRIVEGDEEKAAFITNRGLYEPLVMFFGLTNSPATFQTMMNSVFQDLILRGKVIVYLDDIIICTSDLDEHRRIVRQVLQILRDNHLTCKPQKCEFETQETEYLGHIISPGKIRMDPGKIKGVTDWPIPTCKRDVQSFLGFANFYRRFIKDFSKIAGPLNRLTGLSEWTWTSEHQLAFEGIKHTITSAPVLAIPNDTDPFKVECDASNFAIGAELSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYE4</accession>
    <name>A0A2G8RYE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYE4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYE4"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39162" checksum="CC8BBD9F55B23DFE" modified="2018-01-31" version="1">MSSNSTSSTPTLLDANKADETPLPPPLEGIRRDWEFWIEDGNLILVARHIAFRVYRGLLAEQSSVFADMAVASSKDLYDIFDGCPIAASILFVYTRDALLTLNFPGSRLHPKDEKEHACDELSALARLSHKYQIHDVEKQALDLLRETYVDDFDKWYFAFPSFTDSSVSLPYTHCIGVVNIARLTNTPSLLPSALYFCCALGSDLLDSWKREDGCIEHLSIDDLKRCFTAKGRLCHRRVKMMYEVFEDRVSTGCLQANKCCAALREMALSITREKLPPVAHCEALTGWENLICTKVCLYPVCLQCKEELHMRDVRARRELWDKLPEIFEIIVPGWGTTPVNSDVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S126</accession>
    <name>A0A2G8S126_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S126"/>
    <dbReference type="OrthoDB" id="5370359at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="257" mass="27966" checksum="78E97BE408547D5C" modified="2018-01-31" version="1">MRPTPELLLSPCVVACRSTRRLPRLVLAVPHILLLSADETPDRRRRAFPRRPHEKVAQQHAATVALVNSILANPKSYPISGSEDVVCKSLVDLASYARSLELQLAGAPVAGSSKAVVTKPARSQADLEVSAEKLRKVAVSGIKKQMSAESGPHTRRCAPISAPWKPSCKTGSAKWVYDGICNDPEVFGCLMGLGGPPTFKMKKFSVDEFEKCLGALRGSVRFDTLYITSKDVTVRWSDTGEFKFSGSYGKCQPSSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S188</accession>
    <name>A0A2G8S188_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S188"/>
    <dbReference type="STRING" id="1077348.A0A2G8S188"/>
    <dbReference type="OrthoDB" id="3071736at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="447" mass="48522" checksum="4CEB17D86871E8FF" modified="2018-01-31" version="1">MPKVVGRGRSCSATVPSSGHFNSPSFSSSPRRRQRPALPTLSTSASSPQLRRLAELASTPSPSFSTSSSPSLSTVVTPESEYVVTPGEAITESPVDVESPREDEGPGLASRWSLDSVASRPRITQGALDAVPASPVSKTRKRDRLLSLISSRGRSGSVSKILPPPNTPRGSTDVVDLHIRRIDSRDALHQSTTHSSRPSFTMPPRMQQAPSLSSDSSNASSASTLPTPIDPIHTPEFTDPFGTGSPSCMPEELEEEDLPVFAENPYLKRESPLLGESPPKSPSPPLAPHDPLRLQIADRPMSPGSLPPQPTLPLPSPGTPSPSFLVPSPRPQSFFASITGRPKRRKKKLVISGAPLDLSRSRTSSSISSVQAVEDLHHRQQEQQRRVQNVVKWCESFGTLRKIETKEDGSLHVYWKDWEVADMVCRIQAQVVIKEVGRVSLAWSYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2N1</accession>
    <name>A0A2G8S2N1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2N1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="131" mass="14321" checksum="A3A8C7E6FE6B8915" modified="2018-01-31" version="1">MPGTSVAILDASFNFDHVGAALGTRHASSFSFSYLLRRAIQPHSTDRIFFCFCVSTGSRTLARPPGRGARRCHPEPSLASRFAPGLSPQRQNFPETVVSPIFLILTEHPLVLAAHLCQFGYSNEPGELHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2R7</accession>
    <name>A0A2G8S2R7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000029">
        <property type="protein sequence ID" value="PIL28065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2R7"/>
    <dbReference type="OrthoDB" id="2757774at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="469" mass="52117" checksum="85918ACA2EC27456" modified="2018-01-31" version="1">MPQDQPEDYTLLVDILTSCFNLERITISMESDPPPRILEAFRTPLQSLRLLLVYGWSEEASALLLGICAPLRVISLQSEPGDWVGKVPWSPVPLERVLSHLSPTLEELELDEFTVDPARMQPRPAPPITGLVQYPAVHSLTVGCIVGRPLLDRLHHLFPALCGTLAFRALNGSALDLRDYTSTRAANKLAQEDDWARSHRLAPTWKKLDRLVCDPVTFYLLALRCPIRLVMVRYVSADTRGYVMEALRENPVPRLKLSLLLKYGLGILDGLLPPELAGTLTHLTIVLEYANDILPASHAGPNTLARIRWADLLDRTISILKPLHRLTHLRLAVQSDVCDGLAHWPAERSEAFVRAVRADAFDFAGAGSALVSALPSLQYLFLATDGTVSGQVVLLDDSAEDVHEEWHASRGWRVADSQSESMSGADAALTVQDCQRVLVELEDTVMETIVWREERFVSEAEAESLRGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3C1</accession>
    <name>A0A2G8S3C1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3C1"/>
    <dbReference type="OrthoDB" id="2758689at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="47463" checksum="9B861E4DC3E3DA9D" modified="2018-01-31" version="1">MTHITTEGEAMLAFLQALPTSQLERCKIDISYLENNRLRLLPLFSGDVRRLRSLYLSRVPFLPSNTFPGLTTFILDLNNNVYRNKDPHLELADLKNFLDGSPGLENLHLHWVWCHTGPHPPKASNATPRVVLPHLRNFTLKLDSPLISVAVPMILSVIELPHACQIQLAPVSLNELEAMSPSLLSLGRPLTRMRLMLAAKSFPDPAGSPSWEWSLVLASRQADCAAIRLALQPEPVDRTRRIPEGAFSKPPLFADVEELWCTSSLGRYEDDLLCSVLSLPPKVRSLALCIQFWELGYSHGYLARVARVCRQLDTLCICIPNADNLRDVREALTSAGPYGRPRCRAIRRVAVGFDQSSTWLSSGATSWRDCGAGTEVSWTGQIARPSDDEMNSTEIERLLSAAPQVVEEPASIRASWPTFPGFLHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3T1</accession>
    <name>A0A2G8S3T1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_09546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3T1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3T1"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="177"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL28395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="446" mass="48233" checksum="568758E82345C5E7" modified="2018-01-31" version="1">MYSSRSRANPYRAQAPNSLPPSYTVTPRAAPKYPPVAPVPVPIAAPAPRAHSAEAYSFAPNAKDGDGGAQVDVDVDVRQLTPMRTPSPTPSEKYVLTHKSRTCDFKRMFDFKGNPRQILSVALAVLVIVILILFLVFQKRIEEWLRPFADWMHNTPGGWVIPIAIMIVLSFPPLFGHEIVAVLCGDVWGVGIGFGIVAAGTILGELANFFVFKYWCKARGKRTEEKNLKYALLAQVVRDGGFKIPVIMRLSAIPGHLLTAIFSTLGMSLWTFLAAAILGLPKQLVVVYIGVSEADPDSAKKARAIKIAVIVLTALVTHFAMRYIYRKMDEVKEGVVYRRRKARQAKMLTAAGYPSDSVDRTGTGTGTLPKALDADLERAAGVEVMNLNAVSRRSGGGGAPTYSYPESNLNVNPNPFGSSMDTVASTATGQGSRGQPISMGRGKSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3X1</accession>
    <name>A0A2G8S3X1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3X1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3X1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="392" mass="40450" checksum="8359643916BA2320" modified="2018-01-31" version="1">MEHESVAGGRDKHSNKRPTHTAPSGTPPGSSSSPVQSSNKTTTSTWPPRNSTTQAHPTTGTPAATETVPGLSSPLHRSTSATISHWRFGTSRPRRKPSPPSPSPSASEIVGIVLGSVALVGVLVGIVVWRRVTVARGSTSRRGSATRAAEEDDSSGLQSESSHSTLVQQQISPGPVYTKPIAHRHRISAASASPATPVPAGLGSGPAAPLDQGGDVVLHIYDDTEANSVAVAPSTSYSYSDDTLVVLHPDSSPIKPPGLPPARCASETGLLLPGGASATGAEPLPAETTAREDLQSPDMYHISSEPDPHITQTEEAHVEAAPRTRARRVTLTERASDGGVRLAGGLPVSDATVTADSEGVEHCPGGELLSDSPDGSVVEIVALPPPYHHYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S414</accession>
    <name>A0A2G8S414_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S414"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="152" mass="16938" checksum="99468093E1F6B0AA" modified="2018-01-31" version="1">MSLYDFPTIVFTVPHVKCLEEKSGGVICHEAPKNVHVTIAELGVDKPILLVCDTVDGSYIEDPPSVIAQFLLGGDLEVNIETFSSMLKVRFLLGKTQTFNLTFSASSEFWDFIGIVAEIQSKKIDNQTKEEELVRGVFGMVPNVPRVFKQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4J9</accession>
    <name>A0A2G8S4J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4J9"/>
    <dbReference type="OrthoDB" id="2836053at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="157" mass="17817" checksum="0C77F92C161669BE" modified="2018-01-31" version="1">MQVSASAHPPASSVETVESPPSPWLDEYERDEFVLVSLILIKLWEVPLSSHERSSSLQSIVLVNRTWHALIAPIASRDVHFFGFQNAHALSENIYVHCRYRDSFIGDARRLAHEMGHSLTFHCNGNPLRADLSKATPAFWEPFEFKQPIASLMYSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4N3</accession>
    <name>A0A2G8S4N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4N3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4N3"/>
    <dbReference type="OrthoDB" id="3365472at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="36763" checksum="02915990EBC05634" modified="2018-01-31" version="1">MPSEGSSESGSSVVYPGTDCAEKAYLRLSAIYGFDPLPPPPPFSPRATTSAEEPVPRLEGGIIMAARRIQAALCIDKQAKSSWGIPVSSNCEDDNKPIPGWTDGSNAWRPSVYGLAPPRDFTRSDPDDAAIRAYGSYIASPHRSRSVQCTSGKNNPAIKVQIVTSPSLPENAEDASTQELYRQYCQSTAWRSQSRTLPNRGAGFSTSPTCLTRYSPREVPLLKHGAEGRLLVPNVKMRRLKSPSPGADSSFRKSDSLSVGGPHCAPSHNRDEEPNAERSQNYKSEKLTYSIMRLTPKKEQRVERRVIDGVEHVVHVEVLVEEPIKRLFLFGGARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4W1</accession>
    <name>A0A2G8S4W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4W1"/>
    <dbReference type="OrthoDB" id="2749112at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="112" mass="12918" checksum="12ABEC588BF8C015" modified="2018-01-31" version="1">MRYGGRTSTESTTPLARRHSTSTTSSIVPSSYPYRQSYLEIRNGREYMTMLPPMTTEEDLLQEDLIGQPAVYTSYGPFPERRKRMNIVQAIADFIRKLRKSLGRRRPQSDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S509</accession>
    <name>A0A2G8S509_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08887</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S509"/>
    <dbReference type="STRING" id="1077348.A0A2G8S509"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048869">
        <property type="entry name" value="OCRL-1_2_ASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF300">
        <property type="entry name" value="TYPE II INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21310">
        <property type="entry name" value="OCRL-like_ASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="698"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL28841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="874" mass="95922" checksum="1B7E1DECF2CFAA3D" modified="2018-01-31" version="1">MAISLCGGMTFVESLKQSTSIDFLTRRIAELTITINPGGDTPFLPVTLQTSDTQGLRQLLDECKRLKDVSKPDDVYDFEPFAWVAPYTVDHAISPLLSYIPPDLRHGKKPVHARLSLVSAGVPGDDISDIEAIREEWLRKKAQEELFACAHKTQLKVRVGTFNVNGNLPSQDLSAWVRGQIDQPASGPVPPPKETTLSPLIGEARGLADERLDPDGTTPRDDTQPDSSSIATSSDTASVATAVEVASEETAVSDPALDVTEEAGDPDVLVLGFQELDLSTEALLYSTKTAREAAWCTAIFAGLGEKAVLYEKLASKQLVGMLLVLIVKKRLRPNFSDVRTTSVGAGIMGIMGNKGATAIRLLFTPTPSAPSDTESPTKPTALTFVNAHLAAFDEMFEKRNADFHDLCKRLVFEPVISVDDMPSTGSWYSPAAVPLSIFDADMLFWLLASAIAGGKAFDGFVERPIEHCPSYRFSPGLLTDSLGYDTKRKPAWTDRILHMASDRVSLEQRSYTSHPTITMSDHRPVSADFELEVPVVSGQEYESYVEHVWREVSGIEYAEERPRVRVSPTNLDFSNVGYKRSVTRTLLVENTGKVPCVFRFISQSPTADPCPPWLRIEDMTGLVLPGKTVEIAISAHIDGATASQLNLGNTHLEDTLVLHTALGREHFIAVSGDYDRTCFATSIAWLVRLPGPARTLQAPSDVLPEDRSVNAPREIMRLVNWLMSNGTQADGLFLTPGDEELVRRIREDLDTGEDFSVDNVATDPETAIAFADTLLQLLDSLTDPVIPASLHAKCTQITSRDEAFEILDELPAANVNVWISLTAFLHYIGQQESYQDKAEQLVAVFTLVLFRDDLTSPMPVSVTGRRNFLRYFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5S2</accession>
    <name>A0A2G8S5S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5S2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="65" mass="7149" checksum="B8A045659768AF5C" modified="2018-01-31" version="1">MAYEPPENECWVRVPAVVNSNQSHLRDLRVANLSPEVFPSNQSGLLDHGGVNSGTQRPFNAACDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S634</accession>
    <name>A0A2G8S634_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_09243</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S634"/>
    <dbReference type="STRING" id="1077348.A0A2G8S634"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="568"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="512"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL29194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="988" mass="108437" checksum="63C16E2E56FD6B2C" modified="2018-01-31" version="1">MSSPPRDIPTSDLDDVEMQLDQGSVEQSMPGAPAPGPLFLEGTPSIAGTPRHNAVAMRAMGLSTPRRQKTPLFAPGTSSPLPFPSSSPTKRTPARVRRLDSDLLDVPGSQDSEPLTFPSSPARGTPKPAPKNRRGDIHSSFSFTPTSLRSRVRTARKEGPLDDLRSDASHLSIPAPSALDLSVPAVPSDDDEDPGAFQAIWGTSISVHETMRAFREFMRGFKVKYRIAYDRERGIRTRVLSSPEEGEVLLYESYVRRMRQTGERTLNLDIANLAAYPPSKKLQILLVKYPQEVVPIMDQVLKDVVLEVAEEDQRAGADGMRGGQGNKEMEEMMARVYNIRPFGVPAVNMRDLNPTDTDKLVSIKGLVIRATPVIPDMKVAFFRCLTCNHTVQVEIERGKIDEPARCPRDVCATVGSMALVHNRCEFADRQVIRLQETPDAVPDGQTPHTVSLSVYDDLVDVSKPGDRLVVTGIFRSMPVRVNPRQRTLKSLFRTFVDVVHVKLGTDDRLGFDRSTRPAGGDRVPGVGGVGGGVDMDDEEENAVERQQRTTKREELEARLRLLSQRPDIYDLLARSIAPSIYALDDVKKGILLQMFGGTNKSVARGGGGGGPRFRGDINVLLVGDPGVAKSQILQYVHKIAPRGVYTSGKGSSAVGLTAYVTRDPDSKQLVLESGALVLSDGGVCCIDEFDKMSDATRSVLHEVMEQQTVSIAKAGIITTLNARTSLLAAANPIGSKYNPNQTVTQNIDLPPTLISRFDLLYLVLDNADEALDRKLAQHLVSLYLEDAPETGGGQDLLPLEELSAYITYARSRLNPTITEAAGDELVRCYVTLRKAGEDPRSNEKRITATTRQLESMIRLSEAHARMRLSPFVELGDVKEAYRLMREAINTSARDPTTGEIDMGLLDTGIGRQQRKLRGDMRRAVLALLDGAGATRGVRWADAMAQLEAQSSVKVNTAEFQEVIRELEQEGLVKVTGERDRRMIRREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S689</accession>
    <name>A0A2G8S689_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S689"/>
    <dbReference type="OrthoDB" id="2766567at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="226" mass="24705" checksum="475D52AEDBA0A576" modified="2018-01-31" version="1">MGFFGVIVTQFILYIRRYPKDRMFLKLLVYGVTLLQAAQQVLFTVNAWGVVINPGVSGQVLQRVTASNILIDAVIVAISQAYVLLFCVYYAGRGMRKIHASITSSKLLLIIGTEVHFGTGQHGLSVVSSDDDTMIKGILISVNAVTWSTDVLLSAIFVYSLLKSRTGSSFGNRLVDRVAYLNMNIGVLPSLSALAMLPMFQTPSSQRKPSCKETAFLFTLQSSSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6H6</accession>
    <name>A0A2G8S6H6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_09424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6H6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6H6"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL29373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="548" mass="60621" checksum="A034BD678829539E" modified="2018-01-31" version="1">MDGCLIVQFAHSMIALVHPSSVKQAILSSITSFILALISTQYSALTTVGNAQDIVLAFGIHLISLFCSVFIYRISPFHPLSSFPGPILPKITKFWGVSQSWTGRQHRTFLHLHEIYGPFVRTGPNELSIAHAQAVNDVLGAGGLDKGEWYSARQDPNAPKNLIVLTGEAHANRRRLWNRALSNENLTAYQPVIANRIDELVRHLVQVAAQSEIVDIGQSIAYFTFDFMGDMAFGGPFHMLSDGGDKNDFWGMLNRFAISASVVSHIPWAFPLVQAIPSLSKDLRRLRRFGVESATGRLQEGSKTKDLWYHLSDEAELEKMRPLPPNVVADGALAVIAGADTTAGALTALIYFVLSDATTYHKLRNEVDTVYPAGSDATDATLHDRLVWMDACINETLRLQPPVPTNGPRQVSYDGHGVIIAGRYVPPGTQVYVPPYAIHRDARYFSPSPECFLPSRWLPHTPEPEHPDGGFVLDRSAFIPFSYGPANCVGRHLARMEMKMVLSVLVQKFNLQFAEDFDSKGWCDTIKDYLVTSRGPLVVKLTPRDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6J3</accession>
    <name>A0A2G8S6J3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L34Ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6J3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6J3"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12720" checksum="3B1F0D24F9B0352A" modified="2018-01-31" version="1">MAQRVTLRKRTPYNTTSNRRRVVKTPGGKLVYHHLKKLATSPKCGDCGIALPGVPALRPRQYATISKTKKTVRRAYGGSRCGDCVKSRILRAFLVEEAKIVKKVIKSQEKGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6J9</accession>
    <name>A0A2G8S6J9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="12">ETF-QO</shortName>
            <ecNumber evidence="12">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_09454</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="12"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6J9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6J9"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="11 12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="392"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL29402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="432" mass="47721" checksum="7EA4F7DCC946152F" modified="2018-01-31" version="1">MKDSFEPGMEFRARVTLLAEGAHGSLSKEAIRRFNLRKGRDPQTYGLGLKEVWRVDPTKHQPGKVVHSIGWPLSYQTYGGAWVYHMADGLVSLGLVVGLDYQNPYLSPYREFQRMKHHPYYRDLLSGDSTRIAYGARVLNEGGLQSLPQLNFPGGALIGCSAGFVNVAKIKGTHNAMKSGMLAAEAAYDALESQATSDDNPTDMSAYDEALRKSWVYDDLYEVRNLRPSFNTPLGLWGGVAYSGIDTLFLKGRTPWTFRNRSGKGDAAHTLSSRECEPIDYPPFEPPLSTDLLTSVTLTGTNHAEDQPVHLRVRSYLSEDGAVNAEGGESFKGLKTEAWTENADIRREHVRMNVGEYAGLLGRGCPAQVYEYVEDENADTAVEPEAVGWEGKKLVINSQNCIHCKFCDVKVPTQDITWTVPEGGGGPKYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Z6</accession>
    <name>A0A2G8S7Z6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Caudal homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Z6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7Z6"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009948">
        <property type="term" value="P:anterior/posterior axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047152">
        <property type="entry name" value="Caudal_homeobox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332">
        <property type="entry name" value="HOMEOBOX PROTEIN CDX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24332:SF9">
        <property type="entry name" value="HOMEOTIC PROTEIN CAUDAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="3">
        <location>
            <begin position="65"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="58779" checksum="E4D8AC6CB30D5884" modified="2018-01-31" version="1">MGSLQEKPESTASSPQSSALSPPQSALSPTQSDAASPSSNIPEKRDNPVIRKAISCSSLTSDVKQRRKRSRVTPEQLAKLEEYFASDNSPTSARRRDIARQLAMDERQTQIWFQNSNGRRAKAKLQLKLKARSVEKLEPPPESPPELSSGFDVDIHGLIHEDDDVTVFPCTDLTIGSWRRMASPHHDLIAYTCNTKRCLVWYIRSAGRGFKMEISFDHVAEARFTNVSPGIGSATFVLDRPPGFYMESPVNPALVDEHVRVWQVSGDWTEAMQGSTHLRHCLVGPAYQLSALVNNIAPSSMTSEIPVYTPTPSISDAGSSPEVYTRSLHSPVEQMYQGSSLVLRRPSSLSSLRMLHHPSLERLRSKHVSVPLFHSPLSSTSTPTSPYAPSDGSMSMSPTILYLDGPEGQQYHDPSRQSATTTPDQLTRLPLAMPNLPRMNYDGPPTSRSVSPYDCNTDTPSSAMSGQGFFEVSPTHPSNLQWGGNHGPMGPPGPLAGVYVPHNPTVDERSQEPYFQYPNGLAGPAPPAFGYEGGAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S891</accession>
    <name>A0A2G8S891_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_07907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S891"/>
    <dbReference type="STRING" id="1077348.A0A2G8S891"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018820">
        <property type="entry name" value="BRE4-related_DUF2421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF1">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10334">
        <property type="entry name" value="BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="774"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="803"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="829"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="9">
        <location>
            <begin position="750"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2421" evidence="7">
        <location>
            <begin position="887"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL29996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1131" mass="127217" checksum="7BC6F12DFE478387" modified="2018-01-31" version="1">MSTSAKEGPMNGGRRYDPRFGDEDDALPTPRHVRIPDDIPHPGGGSEKRSKSPPRSRPDTSPKISITTRIAKLLPFDLGWIRPNLTWSKLKPVIRCAVVCWVSAMLMIIGPTGRAFGMSSFQLLISAYLDTPHDPFIAVLERELIFTTLVLTAWAWSCLGIFLSQLARTNIDYTAAPDDVHSAKFVEAGPTVILAVFIFFGSAFFLYLKARLGPGPYMFATVFSCICLDVCLTTQVLYPFPFYLLGRFIALPLIVHCGLCVFFAATIFPTTISARYCQTLVGVLDPLNEFLAQHRAVLTHDPSGDEFKTTVDKIRDALGRSEDGLGPAGATSRLLNQDIVYGRFSPARMGVFQTCIRRLISRADGMVVFFSLIDPLREAFPMTPIPSRVGTPFTMTPVTSLPGTPTSPGTPIEMREDVAHTARHRPRVQTSLSRYLHSRLTHHKEQHHDSHLHTSLLHLAQKLTPPRVGPTLSLSETAVGVFESQRYIAIEATRFNHRMADYTTQFTALLHESCDEILGVSQDVLQGVQGWFAEARSESFRGQVAIERLRTERLAKLEVLHKNIKEASERFRNDKRLRVLEPYRYAFDQKTLHPEEVNVPPHRYLFHCFMYQYHVMRFSAILTEILDNIITLETECSKSRLWWPSEPFRRVLQLNLWSHAEGMDQEDDEDPDVVQGIDPAWDQDLGMTGRRDPDALPPSNAFQWVMHWIHGWATGITRGNVLFALKAGLLSVLLCIPSFLRSTAGFAYEQRFAWAVFMGQLTLARFRGDTVFALVVRVFSTIFGSVLGLALWYISAGGGKGNAYGLAVVIGVSSPFLVFWRLYWPVHPITNIVFFVTATLVVGFSWQNHHTILPITYQGWDVAWRRFVTVICGVVAAFIFSLLPPSTTLRKYQRSMMATTVAELGTVYCSIVSFANTREHQEVSRAEIAQSLVAIRLKLKRSIFLRTNIVYEYSLRGRWPSERYQKILDLQMQIANLLSHLMSVAEHLEPAWSRAFLLRTRFLDADFQGDILAVISLISTALRTGNPLPQITPCPLLDRFMVHTHGLNVIRHEADDDYGLPRTMTMDTLANEQYLAFSVGVTTAFGIVLRLDKLMVATKEIVGEQYHIHGIGVPEPRTAAPSPVDRPAKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S971</accession>
    <name>A0A2G8S971_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S971"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="122" mass="13028" checksum="A45D5B79E51BFC69" modified="2018-01-31" version="1">MRHLNETSSGSSGAVCDAADARRTKKRRVGDVDELWGCLIPWNPANPNLRSIELSKAKRKHAVGSSLKSDICLPASAGIGEAYFGRVLAVLVSCANDASDCEEDEAHCVIEWDGSRGTSITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S980</accession>
    <name>A0A2G8S980_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S980"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="117" mass="13669" checksum="CCFD828ECB5A6A7C" modified="2018-01-31" version="1">MDTQDSAAEIAQISYLVSDGRVFLGSLGEYDSRKTLFLDFPMSTDLYMPVVLVLYEYLVTFSAEVQLFWRRDITGASILFFVNRYMMLSYVLISLLWYWPKYTAFVFKSGVLARTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9J0</accession>
    <name>A0A2G8S9J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_07606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Homotrimer. Homotrimerization increases the affinity of HSF1 to DNA. Interacts with transcriptional coregulator SSA1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the HSF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9J0"/>
    <dbReference type="SMR" id="A0A2G8S9J0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9J0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000027">
        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF427">
        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="174"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="514"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="595"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL30419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="692" mass="75048" checksum="DE9C869BE713C7DC" modified="2018-01-31" version="1">MDSSPSQFSHTMSSADGPYSQQPPPQNQQWSQQSPSHLLPPPQNQSSFPSPSSPASSLNDQPYPSYFSTSSQQSGQSGMSESLSDRPGDKTTLSLNLSSLSVTSPTNLSPINPSPHPSTHASSHVSPITPISPSGGSLVAHHHPHHAHHPHIQQPFQFAAPDQGVRYDESHYDSYGKRLTSSRSSSSSEKSVPRKRSYTTLAPLTTSVEETGYDMGDNPNSAMYDEVDMSYGQMDAEGSPIDGSNSGGEQDDPMKPMEGQVPAPATSMHSGGPPSLGVLNKPLGTNNFVTKLYQMINDPKSSQFITWTDLGTSFVVSNVGEFSRTILGSHFKHNNFSSFVRQLNMYGFHKINRTPRAQRTSADVQTWEFSHHKFLRGRPDLLEEIKRKALEPDPSLKHRVELPGEVAAQLSQMREDNRRLMVAFQQERQKVDRLVSVTKAMYDVMVKTCGMPVPFPNDILDPGESPNIYVTSPQNSAPPTSHFPPLSSLQTGSLHSLHSISPSSSPTAAEFPSHSHTPHTLSRQHSYQHIPSYDGMHHAHSHHAHHQHPHHSQHHGIHGVSAARYDNPMATPLPPSPGPMDYDERVGAKRQRTAPGSGSIPMPGSSIDGGVSGSSLKKGSRARSDSAPLGYGLTSWPQTRPRSGSGLGTRGPLVGGAALNGRREEQVPNIGSLSRGQLPMLSIPSMTKQPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAE5</accession>
    <name>A0A2G8SAE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAE5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAE5"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="159"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="40"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="412"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="568" mass="60435" checksum="3B93C20CB40F0A12" modified="2018-01-31" version="1">MNFPTSDMHSFWDINAQQPDSFSALPDDDFLAFLQKQFPSAIGNNDPAPLSFDNPDGVDPQRINSFPPPNLSPPSSDSSPSPPSTHHESSLSRRQSGVFASAPSSGNADPEDGSLKRKAVDNADEPQSKTQHTSSPGGSNKKTVSSASARRKPGAPQDETRLLKRKEQNRAAQRAFRERKEKHVRDLEDKVAALEAKNQLTEQENENLRDLLQRLQNENMMLKQAAFTFSAPHPANANNSHNQNAFGSNNTNHPMQFNFSSPGAGPSKSPMQTQSPPSQYNLNFNSLISFDPNMLNTADEPQDVNMDAPFSFSNEYKTIASNPMFTSFAEPSPADSPPVVMNGGGQQYLPSSFESFDHWTPSDTHSSTGQDALDQLFGGNFLGTNSASTNDFHALLATPPSAISPVSHQTRTPSLSSSSSPAGAASTSGSSPSAAAHSPSSGHPPGHSTEECPKTKEQLSKAIAQAGQSSFVQVSPFVQNVGASPAASEKPSEDGNSSGASCEMPFAPFLRKAAGENGGTPFVMCKGSSFPKTAKSDKNIEVLTAWRTITSNPQFKVGVGIGVGVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAU3</accession>
    <name>A0A2G8SAU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_07049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAU3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAU3"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="7">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="86"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="218" mass="23803" checksum="0DF5669347D1D384" modified="2018-01-31" version="1">MSAHDNEELIDYEDEHDVVTNGAPAAAANGATVAATAGDVDGEKDKKNFSGIHSTGFRDFLLKPELLRAISDLGFEHPSEVQQECIPQAVLGMDVLCQAKSGHGKTAVFVLATLQQLEPVNGEVSVIVLCHTRELAFQIKNEYTRFAKYMPDVRVSTFFGGTPVVKDADLLRDKTKCPHIVVATPGRLNALVRDKVLDASKVKHFILDECDKMLEQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB03</accession>
    <name>A0A2G8SB03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB03"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB03"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF44">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="471" mass="51274" checksum="3AA54ABEA3060A75" modified="2018-01-31" version="1">MAANKGPFNAPPRPHPPPVHATMVQSDPHPTEPSTIVPLLSRALHRIRSTPPRIIASPATQPRRAAVAIIIRVTPPPTYVLPQQPITDGGSPANVPAPSLTEFFQLDWVNAPGARPEILFLRRDKPDSASDSGHMSGSGPITREAHVAFPGGKTEEGDEGGLYTAMRQTWEEIGLDLAESSYTPIGQLDDREITTSLGKRLLMILSPFVFLQLSPQTTPVDPSPGTTLHWVPLASLLPRPVGDGPRWSSVSVDASSRLAPRHSTILRLLVRLLVGSMKFPAILIPAGAVPSTSSEVTDEKTIDAKRAQLEGNGPSPMKRQHSFRSRHGHNDETLKLWGLSLGMTLDLLAHMAPPEVRRGGAGALLLPPDVESELLRVPVMAPSLASVFPRFGYPDVNFWIWVFGKRYRAVIRGWESSVRSGGTNDRRINWTGSALTTFYAAVRKALVVVIIVRAVWVLLGLLCGGWLLFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBN1</accession>
    <name>A0A2G8SBN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_05873</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBN1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBN1"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="27"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL31176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="36514" checksum="1F45AC281092DA47" modified="2018-01-31" version="1">MSYQLFAMGNPLLDMQVTNGEGLLQKYELKSNDAILAEEKHQPIYREVVENHKITYVAGGAAQNAARGAAYVLPPNSVVYTGCVGDDDLAEQLKAANAREGLDQRYLVKKGEKTGACAVIITGHDRSLVTTLAAAEKFDKAHLASPEVAPLIDAAKVFYVEGYFLTHGTESALEVAKKASEAGKIFVLNLSAPFIPQFFAVQLQQMLPYVDFVIGNEAEAEAWASANGLVDKTDLAAVGRAIASQTKANASRPRTVVLTHGPKSTTVVTSDDVENPKVYAVHALSDSEIVDTNGAGDAFAGGFLGGLVLGKNIDECVDAGHKLGAMCVQQVGPTYKWPKVSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBY8</accession>
    <name>A0A2G8SBY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBY8"/>
    <dbReference type="OrthoDB" id="3245657at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="382" mass="40407" checksum="432A1DAE9E342FBB" modified="2018-01-31" version="1">MNITIDDADGSIQYSGKWHTDCPSHLEAVCIDPNKVHNKTVHWNWPSDSDGSHGSITISFSGTAVYVYNVIPAAHALEAAVANIAFTLDGIPVQSYEQPQGSGDPEYLYHQLVYMNDALSNGTHELVIVGGKSLVLFDYIEYTSESSDGFPPAMTPISSPTTTSPPPPLAGPPTMPTSTVMTPQHTTTLVAPPLDTPDTPTPMVTDAPTSTATGGFTSTAIDTTTAMATPSSKGGSNRSAGAIAGGIVGSVLALLLLGVITLFVRRRLSAHRGGKGMGRLLDEGPPPRMDIADHSMSNRGQFLRPTYPALRPSPDVPRSPGYTSSSMPTSPTSYGGEPPSRTYMNDGTVATILEKADRARTEWPSSTGTRAFPAAFGTMERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCL5</accession>
    <name>A0A2G8SCL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCL5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCL5"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="14016" checksum="4E8A07C09BA616E2" modified="2018-01-31" version="1">MATLSDDTLRKILVQIQQTAVQSQRALNVSKQQIAAKERERRILQLTIEEITSLQGDVNLYKGVGKMFMNVPRPTMEKDLKAEEKELSEDIKNLEKKSKYLEKQFNDAQAQLRDIFHSAPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD57</accession>
    <name>A0A2G8SD57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD57"/>
    <dbReference type="OrthoDB" id="5372118at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="181"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="341" mass="37574" checksum="8FAECA488B95CA56" modified="2018-01-31" version="1">MPSNQSTFSISITFQASRLPSEVWASFRENPHASNIMFAYASKAAKFPHTATGENVWIVLWDTPDNRSSPSVTFVLSCTTGPLGPYPVFIYTPLSSASLKHAGILPKLLAIARALKTSVPPERVFSIFAVDSIASTFADIWTTETGIPLATSPQYYHASLMCCDANLLRLRPLPSLSGADILLRPAVTSDIANVSRLCHAFAAGSEPFVLSNENAIREATIMIQNNHLWVHEVRPSDREPEIASIVAATRTTDTVAAITKVFTNPKWRSRGCAERLLRHVCQQLLKEKATIILYVAHDNPAALSVYRNVGFVGFTPYSGGRMNESWKELGFDRSRVELGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDA4</accession>
    <name>A0A2G8SDA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDA4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDA4"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="530" mass="60441" checksum="43B752A5AC97C5C0" modified="2018-01-31" version="1">MADRPDSLFSGKHERSDSKIPLLPYADSSRPSSPTSPSSARLYMSSLPRRRLLVALLSLTVLSVLAFSLTTLVYTHPAAFQLTPDPEGAPHQQLDVDEPIPLSNSTNPSEHPAVPDPELHTEPESEQEEVYSYSPAVLGPPTRSFRDNLLNDTKYITSWPSAGWTNDVMTYANLIYLGSLTERVPIVPMFTPSHIGGDANTIAFGEVFDVPRFINESGIDILEWDEVKDPESDLVDDLGCWNIWEAVQSNEHHPRNSAAPDWIKLDLSYTKAPDWVKMIPNYQHDMCSTFMSLTRLSYPQERSRNIGHAEPSPLHNAVLDPDDHLLCFDYLYYACAQQSYEYDYDYAPMWRNVLRHAHWTKRIEMITAHYVRQIFDLPPGSDLLPYIAVHIRHGDFANWCWMAENPEDCFAPIPVIERRVTEVQQELRERKGFDIPSTRVVITSDEKDTAWWDQIKALGWKTVDHDAFRTAEVFGRWYPVILDAAIQSTAVGFVGTDRSTYSILSRRRVESWHDGATRTIMWGYKGADDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDZ1</accession>
    <name>A0A2G8SDZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDZ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDZ1"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="40"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="190" mass="20662" checksum="4D461547451552A4" modified="2018-01-31" version="1">MAAAAEDINAVLSQTGEPRLTTMVPEGSTPIDVGVTYTPTISAYKLWQLQKARTTLREEYLAAWRASVAYTGTGRPVDAIIAPVAPHAASPHGKTPISMYSAVWNSLNYPCCIFPVTTVDPILDPAQPRAEYLGKADRLNWEMYHPDTFEKAPVGLQLVGQTLEEEAVLRMAEIVDAALKGYTSVTKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE13</accession>
    <name>A0A2G8SE13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein bL32m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE13"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE13"/>
    <dbReference type="OrthoDB" id="2014905at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_bL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051991">
        <property type="entry name" value="Mitoribosomal_protein_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21026:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL32M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="13717" checksum="F057C7BAA33E8C2D" modified="2018-01-31" version="1">MAALALHQSRTWMSAAARAPLMRMSLAAAFVPAFLASPKPFTWAIPSLPSLLELFPPWLLAVPKKKTSHSRKAMRSANKGLKDKQNLVHCQACGSPKLAHHMCPNCYRELNMERKAKNRTPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEB5</accession>
    <name>A0A2G8SEB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 9">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 9"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEB5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEB5"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL32114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="355" mass="40822" checksum="8A19BB99F08D2B78" modified="2018-01-31" version="1">MSRKTQKPLPPFHVGDDYKILHGLGEGAYGTVVAALHKPSNREVAIKKVLPFEHTLFCLRTLRELKLLKFFSETCVNENIISILDIVKPSSYDDFKEIYFIQELMQTDLHRVIRTQQLTDDHCQTLRALKTMHSADIVHRDLKPANLLLNANCDLKVCDFGLARSTRSTNPGGKEAGLMTEYVATRWYRAPEIMLSFKMYTKAIDIWAVGCILAELLNGRPLFPGRDYGHQLDLILDVIGTPTLEEFYGITSRRSRDYIRALPIRKRRPFTALFPKASPDAIDFLQKTLTFDPKKRLTVDQALEHPYLSAYHDPEDEPAVSSLDPEYFEFDYQDLNKEDLKKLLHEEVMSFQSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEC5</accession>
    <name>A0A2G8SEC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NOP7</name>
        <name evidence="7" type="ORF">GSI_06761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEC5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEC5"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="365"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="631" mass="70579" checksum="32FFDB2698892041" modified="2018-01-31" version="1">MGRLKQKGKAGAAKAYMTRSTAIKKLQCSLADFRRLCILKGIFPREPRSRKKANKGSSAPTNFYYAKDIAYLAHEPVLRKLRDHKAFAKKLARALGRGEWSSAKSLEENKPVYRLDHIIKERYPTFVDAVRDIDDALCMIFLFASLPVDSKVSSTLTENCARLAAEWQLYVMHAHGLRKVFLSIKGVYYQAEVFDQTITWLVPYQFTQTIPPDVDVRVMLTFLELYQTLLGFVFFKLYTDAGLVYPPPLDTAKDDGAAGVGAFSLQETKDSRSATTAKSKVVEVDGKRVSSKDVRQTIKTITTAGPSDGPDVDMHAIDSSVANEEDEEFVEDTAEEDTDDAPSAPTFTTATLPTLKTLSALPQSTSSKLFASYTFWISRETSRPIFEFIVRAFGGRIGWPATSGSGSPVDEADDTITHVIIDRPVVQRTNESEEERERRRRRKHVQPQWIVDCVNAGKILLEDLYAQGKTLPPHLSPFGEHKDAYDPTVGIAGTEEDEEMEDEEIIEGEDDEDEEEEEAARPGKAALNAAAAAAEDATALRAAELAAEAAGVDFGTFEKETKKAHKKAKSAQAPKDDEAEQDMNKMMMSNKQRKLYERMKYGEKKRATERQELEQKKRAIEKEKKRRSKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFK9</accession>
    <name>A0A2G8SFK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFK9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFK9"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="2">
        <location>
            <begin position="42"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="535" mass="57555" checksum="7E7C2964DE2DB759" modified="2018-01-31" version="1">MVRGRRDTLESPRLTTQRPLRIVASGTLFVTNNLGLPTHPDANSVVRAHTVSRVRGGSASTCLSIIAQFPSVEASLVAPLGGNEEGRRIIAELERERVNTRYCKVWSEAGVPSAWVLHADDTDSRTVINNNPLPDITHEEFISLVGPLLVPENYAYLNSPLTATPPTGSPQTPNAPSGSGAPRPSTSNVNGTVAARLPINSPAPVDWIHFEGRSVKTTLHNIVGLDGLARERKWRSHCVFSVDVGRRAHQGVEALIPHADVIFLNKHYARAHSPQYASSPRAFLLSLTSVAPPHALLVAHWGSDGAAVLSVPTKEYIQSSGWVEPIVPPLPVPSRMGDTDLHSVRTGSDFWAGAGNETESSSMFTADLLNSSPARRPNNQTSQNNNRSKRNGKRAARRGDDDSSDSGTDSDGTQIAGRGGGGGGRRPTMEQSRPKQPAASEVVDEVGAQDAFVAGMMWALNRRLLPGDPYTPSAVGSDATIAGVDTDQKGRWRLEECLRFATELAGRKARRNGWNGLADEMARAGWFESWTLNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFU1</accession>
    <name>A0A2G8SFU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_05340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFU1"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="437" mass="49170" checksum="66D7B2A3CF1EF823" modified="2018-01-31" version="1">MSQDPAEQNIQMWKVKKLIKSLDAARGAGTSMISLIIPPKDQISRVSAMLTQEYGTASNIKSRVNRLSVLAAITSTQQRLKLYNRVPPNGLVLFVGTILTDEGKEKKVSFDFEPHKPINTSLYLCDNKFHTEALQELLESDSKFGFIVMDGNGTLFGTVAGNTREVIHKFTVDLPKKHGRGGQSALRFARLRDEKRHNYVRKVAELAVQHFITNDKVNVTGLVLAGSADFKTELSQSDMFDPRLGAKIIKVVDVSYGGENGFNQAIELAAEALSNVKFVQEKKLIQKYFDEISQDTGRYCFGIDDTLKALELGAVETLIVWENLDITRYILRNAANEEIVIHANKEQEKERERFIDKSTGLEMEKVIDPQSLLEWFAEKYKEFGANLEFVTNRSQEGAQFVKGFGGIGGLLRYKVDFTNLQTVDDDDDEFFSDDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFZ5</accession>
    <name>A0A2G8SFZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFZ5"/>
    <dbReference type="OrthoDB" id="2728951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="164" mass="17923" checksum="BE64810102202EBA" modified="2018-01-31" version="1">MSYKQMRKLSGPCVGTKFQDEISAHNELRAETVAVRGPPSALGMYRPVLKAAAEVAMWSLDAAPPQLKECLDEQANLLNVPRVRCERNTAFPFMQMNIVSTQPAGQAGTKIKRELGKVGGKHSDTHDAAGSITTMITDSDIDPETEEWGWFVICDLGVANYEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH64</accession>
    <name>A0A2G8SH64_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_04551</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH64"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013988494" description="Hydrophobin" evidence="6">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="10350" checksum="228F371073266BFC" modified="2018-01-31" version="1">MFARLTAVVTIAFAVLAAAADSCNTGSMQCCNHVEDSSSVSGSALLSALSEIGVNVQDVTGQIGLQCSPLSVVGVGGSSACSASPVCCQNNNVGGLVSLGCVPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHC7</accession>
    <name>A0A2G8SHC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHC7"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="489" mass="53964" checksum="F372D28AE1181885" modified="2018-01-31" version="1">MSKKLAIRRAFQSSDHSNEKENSPQTPSLKEYADNTGRKGGSAASHDALLAKDVAYGTGLGVTTPTVLAPVLRTLSAEPSNVVPPTTPQYSEANILAFNAEGLSKVSRDDSDMNGRPRSASTGSKKIRWIKHTLASGLVIEVEATKSNGLLPSLIETSDQPTLHRPIQATIKTPSPEPPQLESDDYYTHLEDWLLDPRQGGDGFFEQYIEDFRAQQELPFHQRTIWQETFIPTLLKFLGTRSDPWDFSGDAFIAVLPDIWLTVYHEPSWPDEDDALVHSLVSDSVIAWFESFASNALAAVEKFLKGSTDGSPCFSRWSERCEGMMRDYRACLDHPGGLGSSGIFSSMFVLAPLSGHLQAIHGGKQIEGAARSSDELEYPFGAIGLAAAAAFRAMQLFRAQLVRYDEDGKILVETPTGDTAEPHIGDAAFNRYTAEERTRRHSSFACNLPRYELDAILSQAHEFVLYLNHDEVNSVDEVLDYDDDEYGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHK3</accession>
    <name>A0A2G8SHK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHK3"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21942" checksum="B36B529C5E13826B" modified="2018-01-31" version="1">MIGQPSPAAVTYYPPHDESIPFAERTEALHQWLTRYYQHGEPTAEETLAVRDGLKEPSSTLDRISKDDLAESVYDGPGDLLSGSDTLTVKMCFAHRLYAPLKDSALYLPPAQGDSENGADSWRNVEVRLMWCDQSIWPMVWGPPLLHKELKEARAAGRSTRNVSFVRLRGANHYAHWDFPEKTLRAFIGDEEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHX8</accession>
    <name>A0A2G8SHX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate esterase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHX8"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013768943" description="Carbohydrate esterase family 16 protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31071" checksum="7E63126C075E3134" modified="2018-01-31" version="1">MRVLRQLLTAVVLAESLALTAFAGGGPGPQPGQIKNLVTFGDSYTDIDGHDDGGTVWPVFAAADGNFTLFPFAKVGATCSNALTYRPFPSLFESQLPAYFAATANGSLRLAPDETVYTLWIGTNDVGANALLTGSQAPGVTVVDTTACAVDWVRALYEGGARNFVFQNMIPLETVPLYAPDSYPNLYWNARRNTTEWSVFMRELTTSGNAIARLQLQLLAPSLKGAHIGLFDSHSLFADMYARPQLYLNGTGPFNVTGASHACVFQENESQHDKGNCTDAPDPDSYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHY8</accession>
    <name>A0A2G8SHY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleotidyl transferase AbiEii/AbiGii toxin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHY8"/>
    <dbReference type="OrthoDB" id="2990568at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25496" checksum="1C8DB5E538871DA5" modified="2018-01-31" version="1">MSNLNIGRLGPRAAGLARFMADRAREAQAPYVLIGASALIIRGVIRRETKDLDFNIAPRKSAELQNAIAPHLQTARNEAVLVDGKTTVDKDAQTSFRIYKQVGLAGDNMKVDVSENMCALTPSAYTNVDGVHVATVPLMLIFKMCAIARQNRSTWSEKALKDAMDLAASLRYLKAYNEVVPADVLRLLAHEQPRFLWSNFWATIGQVASNAGITVEEVEYLLHAVGVSKTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI10</accession>
    <name>A0A2G8SI10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_04808</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI10"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI10"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="662"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="777" mass="82870" checksum="96410E587BD1DA8B" modified="2018-01-31" version="1">MDCQKSPREPSPAQPISPPELDSLHDDPMAAVVAPSVFNAPPTDPRNASAASSGVGKTRYRPAPAKTFQCRGYGECRMVFSRSEHLARHIRKHTGERPFTCHCSKQFSRLDNLRQHAQTVHADKQDQNERMMQELTSLHANMTAAAKGGSSRAKRAGTGSNPAGGSPTNNAALNGSIPTMAVKTEDGSHAVLPMSQRPGTSTGYEGANTFLQPGSSAWHIQTSDVDRPNQRPTNSHSFRDPGQSFRAPASASSASPTSPPSLNQHQLQHHAGQSFLVPSASTFNFSVPDIPSAARPGSSSGSSAATGSAPESARSLPPLSAVVASSLSPVRALPPPPGSSPLAPLSAPSQQQQPLTHSSVLPPPTPTGPYFGQRPSTAELEQYQAWARLGGQSYPYGLPSELDASAAGSSPYADSAAAMEAAARMQEEQTNRRLPEDTTPRFPSTHPQRAGQRRTPPNPQQQLSATHMSRQTLANDLTLDPTTMTAHVSAANGSAEMHLAAQLAAAGATTTTGQSLGPSLDGSPSWNSAMTHLQMRQQLDHLYRYQQQQQHQAVRQQQQQQQVHSRGPPHHPDSSRPPRNSHSSIGPVSAPLRQQLAQNPHLAAQAHHYSLELHRQQEEQLRQRLQAHEETAERERRNSAEEYLMRQQQQFAAVYGSAGAGGPPLSGSPHPMGAAAAAYFPDTTNNSSSFQDGLSRGRHPSHPRPQGLHAHSGAHHHPLHLQVQVQGHAHLAHQAILDGGYPLPDGVGPDPLELGVLGGPGGSPAGMIRYESPLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI11</accession>
    <name>A0A2G8SI11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Carbamoyl phosphate synthase arginine-specific large chain</fullName>
            <ecNumber evidence="13">6.3.4.16</ecNumber>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">GSI_04036</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="13"/>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI11"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI11"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000026">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="10 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="212"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="21">
        <location>
            <begin position="749"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="22">
        <location>
            <begin position="1015"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00074189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PIL33414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1168" mass="128606" checksum="A4C3B5AF99111D1F" modified="2018-01-31" version="1">MTASLLRLQPCWSPSRVLGSVRFARQFHLSHVRRALAPTRPVKAIARAAVGSYGKEDGEEHVLNSPSELARKISAKVLPKIPRPDVRKVLIVGSGGLSIGQAGEFDYSGSQALKALREEGVDAVLINPNIATWQTSHQLASEVYFLPISADYVAYVLEKERPDGILLTFGGQSALNVGIELDRMGVLDRLGVRVLGTPIRTLEVSEDRDLFVKALKEINIPVAQSTAVSSVNDALSAAEKIGYPVILRSAFTLGGLGSGFANNPDELRDLSAKSLSLSPQVLIERSMKGWKELEYEVVRDAADNTIICCNMENFDPLGTHTGDSIVVAPSQTLPDDEYHMLRSAALKVIRHLGVVGECNIQYALNPTSREYCVIEVNARLSRSSALASKATGYPLAYTAAKIALGHTLPELPNAVTKTTTACFEPSLDYIVTKIPKWDLAKFTNVNREVGSAMKSVGEVMAIGRTFEESLQKAIRQVDPRWRGFEAYVQPEDLDRALSKPTDMRLFAIAYAIFNKNYTIDQLHDLTKIDKWFLYKIENIVNTVYALKAAGSIQSVDKELMQRAKRMGFSDAHIADLVASDELTVRSHRKSFGITPFVKRIDTLAAEYPAHTNYLYTTYNASEHDVKFDEHGTMVLGSGVYRIGSSVEFDWCAVTCARKLRDMGNRTIMINYNPETVSTDFDEADRLYFEELGFERVMDIYELEQAQGVIVSVGGQLPQNIALRLKQTGVNVLGTDPEKIDSAEDRHKFSSILDSIGVDQPEWAEVSSVDAAKEFAQRVGYPVLIRPSYVLSGAAMNVVYEESALEYNLSAAASVSPLHPVVITKFIDNAQEIDVDAVAHKGKLLLHAISEHVENAGVHSGDATLVLPPFSLTDDEMLHLKEIAAKVAAAFDISGPYNMQVIRKASAQPDAPAEFKVIECNLRASRSFPFVSKVLGRNFIDTATAAIVGQDVPEPTDIMAQKRDYTAIKVSQFSWTRLAGADPFLGVEMASTGEVAAFGRDVQEAYWASLLSTTGFKKPRAGTGVLIGGDVTKPEMRTVAKTLLDLGFKLYCSSPAVEEFLNDIPYVSAKRIFFPKQDKRKLREVFDEYDIECVINLARARGRDMTDEDYVARRNAVDFGLPLLNNARCAQLFVESLAKKIPEGGLRAYSEGRIPSEVQSWGNWIGSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIT8</accession>
    <name>A0A2G8SIT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIT8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIT8"/>
    <dbReference type="OrthoDB" id="2384193at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="471" mass="50737" checksum="95EFF4802896C64F" modified="2018-01-31" version="1">MVYWHVKTEGADPAVVVRLATFYQLNQVRVVFRFLFTIPLLIVALDGIIGTEHPINTNLFVTDFLQILAGIGCFVSSMFTLLIFFPRSITRESGYKPKVSSTVPHSPKSPEATPPSHSEPFPYDMPANIHMQHIPMHMVGYATPGGMGMSATGGTRYSMAGYTTTGYTESAYTHSVYSPAESLHDSPQYVQYPPSSGEDGADMQRRGSRVSRSSRRLASRRASAYTVRPMDAHLEGGSDGEEYEGDDERRRDKDADRARVTVREDEESAPPYSCSHPPLEPHPRPHGQPDQQTQTQAAHLHQRQPFLLRSDSNTHIPSSPPAAAPTAQDPSLPPPLGPPPSPPAPAYPPNIHATPTASSHSPPSPTSKGKRRTWDWEERRLTPLQGQGRRGSLHLIANGPGAAAVNLGPGGTGVGLGLGVNLNLNLTTGGGGGGSGGNGNGRRKSALHPYVVNFTSPIDLVDLPDEVPRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ14</accession>
    <name>A0A2G8SJ14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ14"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="206" mass="21892" checksum="C20FAA3B96187CE4" modified="2018-01-31" version="1">MVFLKLIGPGVRSTSLCSECATQQFALRATCPVCRKDQTLEQLLRLYPEYSVAPLEAYSGPCQTAPPSPSSDSDSPPPSLRTLRTPSLHSLRLWIDVTGTRFPRTLAAVVPVVDADGTPVFLGLAAFKEGLHPCKICVEPQGLPVPRVSHGVGEVRARGHDAAPAIRPAGDGVGRRGGRGDPGPSRAGTSVRGRRRCSMCGLWLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJA9</accession>
    <name>A0A2G8SJA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_03536</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJA9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJA9"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013923543" description="Lysine-specific metallo-endopeptidase domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="214"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL33830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="352" mass="37142" checksum="B6A348269197D30F" modified="2018-01-31" version="1">MFSNPLRAVLIALVATTSAVPAAAITSLKVAVTGPEAVNGVENLKVIATLTNTGDETVRLLNDPSSILDTLPADSFTITNDNGATPDFIGAKVKYSPTMAATSTDPSAVTIIAPGTSVSFTHDLSAAYNFTGAGYGTYTVEPSSLLHVVGSNGEISEIRPDVEPFVAKITGGKLAVAHPAVTKRATFNGCSPDQEAALETAAAGAQSYARAALDYLRARTAATPRYTTWFGDYTSTRHDTVVDHFSKINANDFAGFKYDCTCTRSTVYAYVYASDFGTIYLCDVFWRVSQTGTDSKAGTLVHEASHFTVNGGTKDYAYGQSAAKALAVNDPDKAVFNADSHEYFAENTPAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJQ1</accession>
    <name>A0A2G8SJQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJQ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJQ1"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL33970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="26143" checksum="2161CF9176DC699C" modified="2018-01-31" version="1">MTGEIQHKGYALVDPAKWTDLPVREFKPKTFEPHDVELAITHCGVCGSDVHTLTQGWGESKLPLVVGHEIVGTVTRVGDKVEGIKPGDRVGVGAQRGSCMSCRACKDGYENYCPEGIDTYNAVYADGVVAQGGYSTAIRAHQQFVFPIPDEIESRDAASMFCAGLTVYSPLKTYGCGPGKKVGVMGIGGLGHYAILWAKAMGAEVYALTHDDSKIDDIKKMGADHIINTEKENFWKDYQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJT2</accession>
    <name>A0A2G8SJT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJT2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJT2"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="677"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="697" mass="77004" checksum="B97C423FA5EBE0C0" modified="2018-01-31" version="1">MDHLISKLQAQARAHSSHPILRRILPEFLYLLNGVQPDSPDVKRRYDELHRDLGMLATEGYWNPSKQDEDALRALKRKLGLLQDDTSDSPRPDAPVDDTPPKPTRRTSSQDMKSDASEPTIHPPTLSTPLLPVSTASPTVLPIELVQILNQTFFLHLLATDPQRVLPPGKSLLSMMSTPRSNSLVSDESQAKLEERVKDMVYSAFWKEAFESLSSSSADKQLPRIRRLYEDLLAALRPLLPKKHPILVTLSLPLSPTSAPLRSVAMHLREILVALRARASPARDTHIDTLLRTLDELNQSALPEDLARLVVNTTRSILELADIMKEDLSQFVLGSMEERELKAVITQQAMLREKALVLQLWPPSSVEPTWRTWLDELDVSAFPDAGAVQPTSRRWVYRLVQALGTNFAVACPLPTTRIPGTDTPGLPEPEPEFGEAPPNTLPPPFFVTTPALLTAQNHLQALVIAASLRSLVRLPSRLALASASASAAGRSSDFMERIWTLLKASTDEEPGAEGTKIVNLADEVVRVRRACADDSGSGGPDLDPEEEARLRAAVDRTLQPRDPVFVLLQRRLLRGLATWLTLVSAAETATASRPVHMHMQTGKERPGKRPRLNLGLGMGNSKGDGFVDWERARGVPTVIKGFEDEVLVREVRETFRKVGTVVDWTDRIWQDLVESGEIGGAVGGDEETRGEDGPEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJU1</accession>
    <name>A0A2G8SJU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_03748</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJU1"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL34039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="30618" checksum="23F758D3E8146DE5" modified="2018-01-31" version="1">MEASPVHFAENPVSSHPTAADNDEPTVILIFGWLGAKMATLRKYGDAYGKLYPSSAQIVIQADSLRYWKLGSARDRAVLPAVQNLKKMGLFSAAPEGPPPRILIHALSNGGAMSLWDMAAVLRKHNIQPPPGSKCAIIFDSTPTPPTYTLTVRAFTAGMRGWLRKLLTAGVLTVVFFLSFVIRTILRRPRPLTREIAGLNDPALLPWTSKATPRLYLYSTADIIVPASSVEEHAAHARMAGFPVEMVNFGRSAHVSHARDYPEQYWDAVKGFWAQATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKF6</accession>
    <name>A0A2G8SKF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKF6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKF6"/>
    <dbReference type="OrthoDB" id="417450at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039773">
        <property type="entry name" value="BAG_chaperone_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329:SF16">
        <property type="entry name" value="BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12329">
        <property type="entry name" value="BCL2-ASSOCIATED ATHANOGENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BAG" evidence="5">
        <location>
            <begin position="284"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL34249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36239" checksum="057562A685E6D67F" modified="2018-01-31" version="1">MAGGRKRGGRRGGGGRGDGGEERRYKAVGCKIGGYHAPSGDSISASTGYRPQATAPSSIHSAATVPLPLTTPHRGPCTRTTAPQLPILFSPIHLVFVPLLLVLARVAYAQASHLLGSSNANSKHMSLVVKWGRERLHFSVPPPDSKLAELRKQIADYTQLPSGSFKLIHAGAVMKDDSAPISAYGIKRGSTIALVGGGEPIKPPSSKASPVHAPKAPRTEESTVSQIRGELDKVRATLKPDVDTFLLALTPASAPAHVGPESTAAVLAPKPASAAASGTRQPLDLEREHVRLGELLLQSLLRLDAISAEGEWEVARRERKGAVKEVQGLLDRLDGGWRARARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKG8</accession>
    <name>A0A2G8SKG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKG8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKG8"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="8916" checksum="FBAB06CE140503B5" modified="2018-01-31" version="1">MSPSPPKRVCVIGAGASGMAAAYALSKHPDKFIVTVFDKELVLGGMATSIDIDSSKYGATYINDGVQGCSPAFANFPSYVQDLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKM7</accession>
    <name>A0A2G8SKM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polyketide synthase phosphopantetheine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKM7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKM7"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="4">
        <location>
            <begin position="680"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117005" checksum="FA8DD3067AFDA068" modified="2018-01-31" version="1">MSVDYRSPRALIESGAITIPELFEWNARENPDYPLFRYPDNDGALKTITYAEAIRAIRLVARHILALVGSAERCAVALLANADSVTYIITSAAVLRAGHILFPISTRNGSAAVSHLLNRTNCRHVLVSEDEYMQTLARGATTDMPDVTLHPLLSFDEIFGGDGDVNGCGTEGLPNEFKISDIGMILHSSGSTNHPKPIYWTHKRMISRGTTSWYGEVDLTGITFACPGTPMFHAQGVSFYLTSVATGLILGVFPPASPPTFPTPENVFENVVALGGYIVTFPPFVEEWVQDPAKVDKMQRMKGIIIGGAPLKEEIGDDLASRGIPLIIWYGVTEVGAIADVIPANPGMDWRYFSVTRWVQSTVVDAGDGKFELVILSSPEDPHPVLNTNICGVDAYATNDLVVPHPTRKGFWKLYGRRDDQIVLSNGEKTNPLPIERIIKEDIHVRDCLVFGNSRFQNGVLVEPEAAFTFDPKDQSLLAEFRNKIWATVERANVFAPQHSRIFKEMVIVTSPSKPFDYNAKGDNRRNPILDRYKGEIDALYAGIEESAQSDILAPSQWDPEAAKAFIRTVVQKVILKPLDDESDIFRSGCDSLQATWIRNTILRALRDGSSELPMDFVYQAPSIAALTDVVRHAALKDDKARDALSAQDLVKMAESYSFNFPFRPGQLRQRDEGKDVVLITGTTRGFGCDVLEHLLRSDDVSTVYAFNRKGSQAMDRQWEGFRRRGLEEDLLQSSKFVMVEADLSIPGFGLDDHLLSGIRDSVTHIVHNAWKVDFNLALLSYEVDLKAVRNIIELSLGSPFVVPPSIQFVSSVGVLRNCALEQPIPEEPLSPASALGTGYSEAKWIAERILCNVAEQYHVPISIVRLGQVGGDRSGYWNEKEWFPAMIKSALFTRCLPNLQAAVAFLPSYPSARAFVEMRNSRSLVLHLSHPRPVPWHTLIVPIAKELGVPLVPFSHWLTTLEKCDNDTLDVRSLDPTQNNPALRLLGLFRSWASTSNPGPVSAMRMSTEKAEAASETLSSLPALDAEVARGWVAGWRRVGFLPMTGQPPPASGARTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKS0</accession>
    <name>A0A2G8SKS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKS0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKS0"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="44"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="204" mass="23673" checksum="728CD61FC916BB71" modified="2018-01-31" version="1">MSNTIALYPLSNFTFSTKEAQPEEDPSVSARLQRLQNNYEDFGMRRTVEGILVVHDHGHPHILMLQIANAFFKLPGDYLKPGEDEIEGLKRRLDERLAPPTDSRQFNASHGVDNEWEIGDCLAQWWRPNFETFMYPFIPAHITKPKECKKLFLVQMPERKVLAVPKNMKLLAIPLFELYDNAARYGPQLSAIPHLLSRYNFIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKS2</accession>
    <name>A0A2G8SKS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03139</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKS2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKS2"/>
    <dbReference type="OrthoDB" id="547796at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="165" mass="18647" checksum="B0284EE936DB44C9" modified="2018-01-31" version="1">MAFDLGTPVNTALLLYILYSIQRIIFPSNSLPQNVPNEFKNGYTWMPKSHPPTLLYQTYTPKTLSPFNGQEGKRILLAIKGVVYDVTAGRNFYGPNGMYANFAGRDASRGMAKQSFDEEMLTPIDQPLDKLEDLTPEEIENMKGWMEHFSSKYIVCGKLVENNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKU1</accession>
    <name>A0A2G8SKU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKU1"/>
    <dbReference type="OrthoDB" id="2729657at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="320"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="535" mass="61183" checksum="3A785315095B6EA6" modified="2018-01-31" version="1">MQVRAAARGFSDHALLDVELETPPWCFLGEPTIGKGSEEEDLLLAELTQTLPTLLPSEAYPPDNWLDIHSIPSDAATTTTSIQLLYQAYQTAWTTHAEPKRFCSKSASWWSSDLTDKSKALRTATRKATPPWQRKDARRKYSRRQRHHPDFLQQHPTWSPTPSTRSRTEKRAELRQAIRRARNKHMETRIREISEEVGRVWDLGKWTHPRRSSMATDLIHDGQTLTDPESLWPAFNQTFHAATHRPVDHSILEDIEQLTPRDWPPFSSQELKDAIKNTTTSSAPGVDHIHWRHLKFFIDPKKNPKTADKILQGFRTLFNACIQYNVWPEEFRRAVTVIIPKPNKPDYSKIKAYRPIVLLSCTAKWLEKVINNRLQYDLHKHGILHPCQFGSAWQKSTVDAVNFLQTHIRGGWHEGLVTTMLGFDIAQFFPSVNHGLLVNILRRYGFSPTFCTFIATYFSPRKSSFRFRNSTSPDFECPDVGVGQGSSLSPTFSAVYLAPVLHAMHGTSTIQSQFALQFYVDDGNLVATSDSTERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKX1</accession>
    <name>A0A2G8SKX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKX1"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="353" mass="38547" checksum="5242CBD42B5FE629" modified="2018-01-31" version="1">MSHPPIIVDSGVPEGSDDYTTVVLFHGYTWSSKACHRMLPLAKASNARLILANRRDYVGAERADLFAAAAVADSEPDAARTKILTWMHDRAREVYDLLVDIIGKNKTPLAHPEANTGGIVVAGWSFGTTLMTAFLANMASFLVGDVDLRKYLRRVVFLDPPDFALGFPQLSPMPEPDALPQGKDQLSDLPLFFSGYFKHGDVDNPDTYEIRTPLADPGPTWLKLTQEDIASFVDAVPGDLRGGMDNTLMTAGMASGAFAALREAAVRLPEEVVRGSGTEAGSSGWDAVEARHVWGDHSMAAMVFAMHSLQVDLEMERNAGVRLRNVTFTRVEGANHIMPWDLPERTLDAILRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL16</accession>
    <name>A0A2G8SL16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="5">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL16"/>
    <dbReference type="STRING" id="1077348.A0A2G8SL16"/>
    <dbReference type="OrthoDB" id="3238224at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="429" mass="48592" checksum="CFBFFB4A84A84163" modified="2018-01-31" version="1">MLPRHSQARNAKLSRIKVAEAPKPRPRLSEEDTRKLTALLTEKFKVEPKDFQVAAIKAQIEGVDMIVQAPTGAGKTMLAAGPHIWPGNENKFTIMTCPLLSLEEEMVQTFETEFGLKAIALNSKNGACEPEKINDILALKYQIILISPEMLQSRPFTNRVLRNTPFMRNMISMFIDEAHCVVHWGAEFRKKYGTLGKLRVFFPRGTPVLAVSATLTPRVVRTIHRSLYFSQSEAQSRFVNKGNDRPNVSIVVRACEHPLNSYADLDFLIPEDLNDPQDIPKTYIYVDNIAVGGEIIDYLNAKIRARLGLEDSNLSRKARKRLQGITLQEWVVTYLMSIVSCNGNFRKHFRTGSSVPGVLPEGEGERDLPYFSLSDLLTTSTYSISHNLLHRSHLNPGRRRHTPRKDHEVQQPRRNVIQSLYVNTHSPMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLJ4</accession>
    <name>A0A2G8SLJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLJ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLJ4"/>
    <dbReference type="OrthoDB" id="2751422at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="48490" checksum="ECB521FA9FD035B7" modified="2018-01-31" version="1">MAPNNNTSLHIPVELTDMIIDFLHDDVQSLLACAVVSHSWLPSSRLHLFRSCTIKDPSQFEVAFRTIVTTQDVSIHILELTIVGERIHCFTLKILKALLGDLPQLRRLSLQKVQFQASWPTGRRFAQRFKYDIGEGIPTYAMLELEVPQWPQRIKPFELEELQLLECDATMANYTHLFRILGLFSSIQTLFLASSSTARDSYSHSARRIPDWALDPVRVAVQHLHTFDIPFPIIETLLKTLGPANALRTFWYDDNVLDWTGAGGPSTNVQGFGRMAASLPAHQQLRTLVLGPLPIFQADLRGNLRDGLGDMQLASMRGLETFHLRGHRLEPHLASVFAALPESVREARFVVVGVSRAHGEGFWNRFYDFAQAFACELARRRRMTFVLDLGVVKQKLSGEKFAALRMAAAIGLRSLRSGAPGRVRIGDSPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM46</accession>
    <name>A0A2G8SM46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM46"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM46"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="29"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="234"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="432" mass="47860" checksum="139A9B7151C627BA" modified="2018-01-31" version="1">MSKYCQYGFEKRIGEAMQARILPSLGIGGAKGQFLGFWAVIMQASFSFFGSEVPGIAAGEVIDATRNVPRALRKVWIRITLFYVGGITISGLLVPQNDPRLGLGDKGDKTGRSAPFVIAFKRAGWAVLPDVVNAAILLSAWSAAASDIYISSRFLFFLARRGHAPNFLAHLFRYPRARAVHSPHSDSDSDSDVDTDSDADSEIVEVGRDEVVLSDAELAGEQVLPSSQPAYVMPLASVLVSASVGLLTFLSYGAGSANTVFNWLVNVASVASLQSWAGMLFTYIRWHQGTVHYERKWRGDDSPEGREAIAQIEKIKRNRNWGQPYLAWYAFGLCMLVLFTNGWAVFVNNGWRIADTLGDSPPNKDVVSQFLSAYVPLPFFLLLTFGYKLIKQTEMIPLEKMTFYQGQLPPYNPEDNEPKGWLEKLLAWLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMQ1</accession>
    <name>A0A2G8SMQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02832</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMQ1"/>
    <dbReference type="OrthoDB" id="10546600at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="385" mass="42666" checksum="CF8E53C0075C7E02" modified="2018-01-31" version="1">MAHIPNELHVLHASSSVPPLPPPAFFLLLVLLVLPALSILVAVYVIPSTHQVVDLVRQPHALLQCSIEARETTLNDPAEDSDCSRVADAKDPLDVGDPSGQSPAPGLAGYSESERVQALEERLDFLRDSCRIMFVQKSDLLAKKDGLLAQKDGLLAQQNVDLATLRTQLAAAHQMKNDLLAEKDASCRLILAQKNEEIAPIKAQLAAAQQNVATITTERDEAYVRASTIADTLEKTREDHEDEVIDLSIRATDTERNSATLQAVVQQQKRDISDALLKNNSLNAEVAKVRRLYDSDLERFRTLERNYSRTIADQRVEIAMLTARLAPATRPRPTPASPRYSLQSILSRLSSESESESDSSFYSIKPSPPRWRRLAIRLPRKAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMT4</accession>
    <name>A0A2G8SMT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMT4"/>
    <dbReference type="OrthoDB" id="2757352at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="87" mass="8957" checksum="AD96762F64594466" modified="2018-01-31" version="1">MSNNANTTSQTASQPAPKKQDSPTQADAQSVLSENSTLCSDSAVAKKDQSSEAKKTVKLSDSSVAFAKKAKEEGWGAPTATRPSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMW6</accession>
    <name>A0A2G8SMW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin reductase</fullName>
            <ecNumber evidence="7">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_02888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="8">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMW6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMW6"/>
    <dbReference type="OrthoDB" id="371245at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 7" id="KW-0274">FAD</keyword>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="20"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL35100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="353" mass="38025" checksum="96BAF2EA45F3E210" modified="2018-01-31" version="1">MAPTSIPPTNVPKSNKMHSKVVIIGSGPAGHTAAIYLARANLNPVLFEGFMANGFAAGGQLTTTTDVENFPGFPSGILGPELMDKFRAQSLRFGTKIITETVSKVDLSARPFRYWREFQEGEEPETADTLILATGASAKRLHLKGEDIYWQSGISACAVCDGAVPIFRNKPLAVIGGGDSAAEEATFRPLTPSSRTPPPPDLTKYGSHVYVLVRRGELRASKIMAKRLLTNSKITILWNTVAVECQGDGDLLNNLRIRNVLTGEEKDLPVNGLFYAIGHEPATQLVRGQLQTDPDGYIVTVPGTTQTSVKGVFAAGDVQDKRYRQAITSAGSGCMAALEAERMIAEEEEGFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN88</accession>
    <name>A0A2G8SN88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_02999</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN88"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN88"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="245"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="355" mass="39872" checksum="9DD0FF1023E97A51" modified="2018-01-31" version="1">MSCTSSSKPQRPALMDVDPPQALQPQQPYAIVRIKRKRNEEPLDALVVDAAPSKKKYRGGINVFQYAGTVEQAEWNDEKQKKELEKHLADLARESSQKTRQAATPAVPTTPSPSAVPQPPRSTPAQPLPAHSQKRPAPQAPSRTYTIVQQDKPVEDPYARRRPANAPPKVWSTRELEAAKRAAQFKMYEAVPSTSTGKKAPVPTEMDAEIDKFLPLLKDYLNVSDLTPPPAKSIKGVKDTDGMDEDYVYDVFYHRPTTNKELYDPTSSNIAKLTGLPPELSGLSGEDSSDEEYSDEDDEDSNAEDWYTNDYPDEEESDREDEADLSDEYHEHSEYDDEVPGRSMTAYRDVMSYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPH6</accession>
    <name>A0A2G8SPH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_02406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPH6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPH6"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="150"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="590"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="372"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL35676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="753" mass="81620" checksum="C4E53171F1D62EF4" modified="2018-01-31" version="1">MLTHSSTRDPLAPFNIDAGLSPSPSDDKCSTHLKPQVPFPVMSRPPTRASTASYSSTMPLNSDRPPSDQPRSLVQKFFGLKQKAKTAFDSEAQHLGYPPYDKGGGAHEAPRIGFWHGWRLIVLGSWLNLLILMLPVAGILKMTTASETLIFVACLFAMIPLIKLHDLATGIVSRRIGGSKTGLLNSSLSNIVELVIATTALHKCELRVVQSSLIGAMLSKLLLVLGMCFFAGGIRFSEQGFDSTATQIHSSLLSISVGAVLLPAAFHFALSYSNQDKGEAQTTLKEQKADILRMSHGVAIVLLFIYISYLIFQLWSHTHLYQDNRQPSARLPAAASVHTATTRLREKSSSIYGRVANARSLENFRRASIQTFRTLSHHDKSPPSSRAPSPGGSSLKPNSPSEISEIARDLGDTPMGGPGSFLRSHAHVYTGSLTSSDGRLSPFTSSSQVTLSNPIALPGESTVRLVPSKQDQFVIRRASSSDSDRSTQDAPVSRPASDVFDSDDERGRRQDARGRSRTPISDVLSAYYSESLKGNSDDGGGKRMSPINLTPGPAWHKERVVESPTEYPPSSPVSTAPGPQQPEMSWPLTLFLLTAVTVLVAVNAEWLVDSMDHLSPLISKEWIGLILLPTVSVMAECVTAVNVAAQDQLTLSISVAVGSTIQTALFVIPCMVILGWILDKPLALLFDPFESVVLYISVHTMGYVVADGKSNWLEGVILMCLYIVIAVTFWFYPGSNFSSNLAVCTTTPFSFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPJ9</accession>
    <name>A0A2G8SPJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02226</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPJ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPJ9"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="45"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="528" mass="59467" checksum="91803C108EE6CE43" modified="2018-01-31" version="1">MPSIEPQAGSVELSHPLVTIVNDNSMSEDDPPRSGGFFQCVHAIVTPTRIFVEGPYHTQSNRVVRKYYEHRDNFILVEFRGENRMPFCGPLKVRVPSPFPSLAYIYHLDKASDCSLVKQCFGKILKQGLEIAGRTFRSLGYSISGLQEHMVWFMSDFEHPEEGSVTPEKILNGLGDFRSCINHPSKYAASIAQAFSDTIPSCKIRAGQWTEEVVDLGTRPYEFTDGQGTISIELRDQIWKVLCEVWPDKRRLVLKPSAFQICFLGYKGIVLVDEQLEGIHMKLRNSMKKFAVHNMAEAEIEIVKAFIEPGPAKLCRSLILVLEDLGVCQEAFLRLQQHATFTVTTGGYSLESTTGLLRRHDLGNVYGLRWTIEHLQDAGMGMEGEQLRPEYIMDNRFIQRLIEFAQAHVLSEIKNDARITIPNAFQLVGCADEGPTYIAQGHNPEDVLCLKDGEIFACVQLPDTDEPIYLRGFVTISRSPYLHPGDVQRVWAIGKPLENDKRLCFFRNLRNVVVMPSIGKLAGSDVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ13</accession>
    <name>A0A2G8SQ13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ13"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ13"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000013">
        <property type="entry name" value="4-aminobutyrate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="471" mass="50271" checksum="84552C0A08A4915E" modified="2018-01-31" version="1">MASTSTQSHESFVQFGKKHVTAGLGRVVDAVLTKGEGSYVTLGDGRKMLDFTCGIGVTNLGHCHPKISKAAADQCMKVVHVQCSIAFNQPYLELIERLLPMMPHPSLDSFFFWNSGSEGVEAGIKMARAFTGRQNIINMQGAYHGRTMGAMAVTKSKTIYSAGFHPLMPGAYTLPFPYWHQLGVDPSTPPSELSEMCLSQLNLLLAQASAPKDTAAIIIEPVLGEGGYVPAPPEFLHVGKSKGLTPAIAYLHGLREICDKHGIMLIIDEVQCGFGRTGKNYYTEYSGVRPDILLSAKGLANGFPLSAVISRKELTDKLAAGSMGGTYAGNAVSCAAAVASADAMKEEKILDNVNARSTELFAALNALRTDADAAVARAVLDVRGKGLMVAVEFASPTGTGPYDRFADPAVPAKLASRVAARCVEKGMLILTTSVYEVVRFIPPLNVSKEDLAEGVRIFEEAVREVVKEGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ56</accession>
    <name>A0A2G8SQ56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ56"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ56"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="452" mass="48891" checksum="8F8729E6DC06BD45" modified="2018-01-31" version="1">MMDTIEQTPAASPDRPDPVGLPTKDNGPIPMSFPAILRNPGLSDRFAHLRIQARVVSPPAVSVSAKRNRREDKEGKQWVRRKENARFVGNSHIVAPSKDDLSVTAPNSRPTFPEPLPHFLSRNNPIPSAVPAAREPSSANAGRFSLSLKGMRRQLRSSGPRTELLVKEVEDEILDWLAAGGVMLAPDASATFDSPSTPIGSTDAILEVSRTPLQLVWNIEDNAFTRYVVHCCARYHDVVSFSKDTAGQRLTYLLRPNVTRPTRSAAPTLDTPPVTDLSELSATDFDTSESDRELSDAEALSPISPSLAAPTTALSAIAEAASDTSAPASPALAPVSACAVYASRRPEISMAALDSDGWSVIGESDGDGDMSAPEAELAALSLADVDRTPLADRRRQGPDVLRSRLLERQRRSASSPSHSPARRTPPRARQRAERAVRAQPVGRRSFYDYLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQG6</accession>
    <name>A0A2G8SQG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01660</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQG6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQG6"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="840"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="870"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="62"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="923"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="1040"/>
            <end position="1096"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL36000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1135" mass="127614" checksum="10533F04AF8F58F4" modified="2018-01-31" version="1">MLPFHASPTHQHPLSYMKMSGGLYEDEYFWRDHQAWLAESGYMLRPRYRKDWEPSWLKSKKFYLLCEDGKGALRNKVMDAVRTSDSRIVFLKQVNKSYCPWEEEINRMFTMSGPPATDRHNSVAPVYEVLQSPLDNNIIILVMPYLMRINGVRFATVGEGVECIRQLLEGLQFLHRHNLAHCDIHVNNVMMDPTPLFSELPHPVRPHKSYDFKRRVTQRTRTSHPTKYYYIDFGLSILCPPADASPLIHVSFGGDKTVPEYEDPSVLRDPYKIDVYCLGNLLQIQFLGKNRHFDVFKPLFAEMTQRDPGARPSIDEAFSQFEQLRGSLATQALRSRMVTNTCRVSMTRDRRQSFHDIRPLHHGDEELEQLQRYEDFTTIDWIQDSIIERNRRLRAARKLNTPYHGPRGNVSLAWIWARLQEVAHAGQSWFVVSLVGIAIGVNAAVISIVTEWLSDIKMGYCSDGWWLNQQFCCWEIDGEGDTCEAWHQWSTAMPARWAIYVLFAAAFSFVAAHLVRSLAKYAAGSGISEIKCIIGGFIMKGFLGFWTFLVKSITLPLVIASGLSVGKEGPSVHVACCVGNLIASMFKGFSRSQVKMREILTASSAAGVAVAFGSPIGGVMFSIEEMSSVFSIKTMWRSFFCALVATVTLSAMNPYRSGKLVLFQVTYDRDWHFFEIFFFIILGIFGGLYGAFVVKFNLQVAAFRKRYLKNHAIAEAVTLATITAMIGWFNHFMRIDMTESMEILFRECDGASDFDHICQTAYQWPMVNSLFLATVLRMGLVVISYGCKVPAGIFVPSMAIGATFGRMVGVIVKAINRAYLGVGIFSVCPPDAPCITPGTYALLGAAAALSGVMRLTVTVVVIMFELTGALTYILPTMIVLLVTKAVGDFLGTTGIAEEMIRFNGFPFLEKDDHAYNVPVSRVMRRDLKTLPVSGLSVKEIEDVLTSTDVKGFPVVSADGKNILMGFIDRSQLRYVLEKSRGLQDVRPDTAVSFARDPEDLEDAGFAGAAAGPAVGLDEELSMGIMENTTMEDVLKLWPWVNQTPLTVSPQLPLEIAMQLFKRMGPRVILVEDHGTLVGLVTVKDVLRFTMLEQHNVQYSPWSGEDFDGLVDEARTLTSNFADDVLSWSRRLFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR34</accession>
    <name>A0A2G8SR34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR34"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR34"/>
    <dbReference type="OrthoDB" id="2751192at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013956886" evidence="6">
        <location>
            <begin position="19"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="111"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="142"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="398" mass="42846" checksum="154087253993FF00" modified="2018-01-31" version="1">MFTTTRLSLLLGLILSTAHNAFIAAQAGVSIEFRKESSIRRPGGTFDYDAALEQIAHDVNKYRTNLINIKRNVGVQGWNEGAELLPPRMYIPRHRKRQSENLSSEEGGTYWIGNISIGTPPQPFRIDFDTGSSDLWVVGNNCSTLSCFSKNTYNPSQSSTGASQLGNFSIQYADNTTVSGPIFTDTVSVGGINATNQYFSPVNTISQSFATEHLDGILGLGLPNASQLNQTPWFYTARAQSAVSEGLFAMKLTNTSSNLYLGGTNSSLYTGDFESHPINSSFYWLIPNGTLVLNGSALATGNTIIDSGTTLIYGPPDAVSSLYQNIPGASLYDLMTGMYSYPCNSTPHIAFNWGGRNFNLSAASFNLGNVPKNKTACVGSILGADLGLGSNVWLLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS42</accession>
    <name>A0A2G8SS42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS42"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS42"/>
    <dbReference type="OrthoDB" id="3267359at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="572" mass="62434" checksum="D6006A07484093D6" modified="2018-01-31" version="1">MPSSSNIDDLLRKLARPAQKVGKTRVKYPWRRRQSQKRGIKLTETERRELKEKREEKRVKLEDALKTARDTMYKLAEQMSEDFGKAHRPEYYYSLIMQQSKLKVKPQKFSRWNVFVSRETRKRNDERGAGNGKRVSDGYIKELSARWREMSEEERDAATADGIEELTERRENRKEGVQNVLINSFHDARATLGSIQQELQFLAGRTGLRIVTIAVRPSSDALNAPFVFSSDERVGYYFETLTKMPMQELVVGLEGFCISGINGLTQNHRMQLGQWKTKVRDFILEKLSAASTRGPINKMYYVNFDQHITVKFGVVLENWPLTKFAAPGSFSAIPLLSLLYNAFDSGTTRFRSLSDEEWLEWLQAYKAGQAPPAVTASPSGLTVEEEDFAAAADSEAPVELSAPAGSETAFASAPSASASSAKEGAPSASVTNGNVNTAPSEVGTGATPSPSAPDVNMAETRITEVAVARGQKRTFQQVGDGNFVNNFVSADGTGIVQITKKPRKQRSDAGKKRGPRKKNPAAAAQASATPAPALPTPSATPAPATPAPSATPAPTLSTSSVSAPRTAAGATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STN4</accession>
    <name>A0A2G8STN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STN4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="31021" checksum="334ECFC191006C10" modified="2018-01-31" version="1">MDALAAHHQKRRLRHRRCVSYPFTRTEFRRARFFWTLGRGGQGIVGVLSGDGVGEGRMGHEASRHLRRIDRGELRTDPNFQAPPMRSYAESSMPEAQNHLGGLCTTVRSLSGAMFRVRRAHEAIGIPSLHRVPTIQRDRPFGHAPDKLPSLTGGAFTHARNCCAPWRLPWCSAPSSAAVLHESRVHAASVGLSHRCCPGPVYLRRHPACPWAMAYPSDPPPPFLRRVVLGRCLFVCSWSRIWRYHPLLFCTHALGFCYSTSTSGSLIADSAPDDGIVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STN5</accession>
    <name>A0A2G8STN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STN5"/>
    <dbReference type="STRING" id="1077348.A0A2G8STN5"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="449" mass="49871" checksum="882BDCBB295ADA89" modified="2018-01-31" version="1">MDSIQCERRRRIWANLYHADRSIALVLGRPIAIHDSYTSTRPPTNADEQTIGSMKSKGVPLSQPTKVTFIILRHQLAHIMGRMSDFFQNVHSPRHYSDVLALDDELLKWKKDLPPYYSLDPDTSLDHTLTYIPLQRFLLVTEFLFVRISLHRPYLLRKLDSTKYSRSRDACFESALKDHQIRLEYIAMTTRQGRDPVASAYREFQAAMIAGIYLVIYPKGKEESKMHDLLDYFLARHKQTAGPDEISRREVKIIEFLKLKSSQSAGTPGNTPIEQGMAVDTPGDFTSSPTAPSDSRESAISRLSQHANSNLPIFSGSSFASVASVPISSPNQTFTHLSRPSPVQQVKHLRSESQSASGSRSPLGEDETAQSLLDQWCNIFSGGPAVDDQSGGASLPWATPGLGDLNGWLGTNQSAVSPHVGSDTLPSVDGSDWSYWETLVNQIRSGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STP0</accession>
    <name>A0A2G8STP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_00827</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8STP0"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="44"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL37135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="370" mass="39599" checksum="A84419102A6BB986" modified="2018-01-31" version="1">MLASRTLVGSARVAVNGRQAFRSYASAAPTAAFAGQKGGNGKYTVTLIPGDGIGPEISDSVKNIYSAANVPIQWEEVDVTPILKGGKTVIPDAAIASVRKNTVALKVGKGHVSLNLTLRRTFNLFANVRPCVSIKGFKTPYEDVNTVLIRENTEGEYSGIEHEVVDGVVQSIKLITWDASERVARYAFHYAQAHGRKRVTAVHKANIMKMSDGMFLSACRQVAKDFPGISYDEDLLDRVCLQIVQNPRPYSDRVMVMPNLYGDILSDMCAGLIGGLGLTPSGNIGRDASIFEAVHGSAPDIAGKGLANPTALLLSSLMMLRHMNLNEYADKIEIAALTTIAEGKSITGDLGGKASTKEYTSAIIEKLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV44</accession>
    <name>A0A2G8SV44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV44"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="212"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="37155" checksum="8BE282E7A40E8CBA" modified="2018-01-31" version="1">MTLSNSRIPVPTNKRKRSPDEGTEGPYKTLKSSVDGLGKQALRIVTDIAPAQAESPTLDELLSSTDSENSLFDESPPQLDTPDISGLHTYLASQLVGQLTPVVPAKRIAPPIPGLYFDPTLLLPDDVTEDLMMTCIRTFFREGTGNQVMLFERVPATHSDSTSPAPPSPTKLPSFLSDLLSTLDTLLRPRVPPGVHDLLFSPSPASCDGPPRARQAIINLYWPGEGITSHVDLLDRYGDGIMGVSLGSGCAMQFAKVPSDQPQSPSVPDECALYLPKGSVVVMTGDARYGWTHGIEKGFDDWVEVSPDSSESVLLERDMRLSITFRWLLPGADVVGSELGEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLK2</accession>
    <name>A0A2G8RLK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLK2"/>
    <dbReference type="OrthoDB" id="5331396at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37849:SF1">
        <property type="entry name" value="YALI0E11605P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="160" mass="17223" checksum="5856D1F6EE08C356" modified="2018-01-31" version="1">MAARLASRSFSLAKAASQRSPSRLLSTTRVVCQETTPNLGSVPPAPKPVGAFRGGVVGFLFGFSLASSLAAYHLLEEYKLASAALQSSVEELQTSTQKVSAHVRRIEAVEKELKALSESSASKEDISRVRAEVKKLYDGLHVEQDLHALSKKEGTTVRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLS9</accession>
    <name>A0A2G8RLS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLS9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLS9"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="392"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="467" mass="53285" checksum="86C9EC6FCFB33DB8" modified="2018-01-31" version="1">METRRSQKRTQFRAGFFASSAADGLPELGACLLGSASDSDPHSLPPPFTLTEDQAGLHLHITYSLDLPPSLTLPRPLSPSPRAPMPARHYSKFIPPSLAMSELVCQKLDNDATDMLIDKWLERPHRPDSYHDWFQRVRERKHLANANAHITRRDQVLLWNKGVFVPENIFTRTVDTGRLIPLDRTWVTHVYHHRSMKRLTMMPVIFSMLPELMLLRGMHDRGCDDIYVIVTDLKRNEMDQVTDYFKYVCQNTAGGHCKPSVEQKINHDYIVLNNALDRRTPCFPQIDLTLRAILHEKRPPFIVLFSHQTMSYSQILFAHPTFVPSKDMYHDFPSGCPNPGCTDNCCELVRFPKQGPENAAVLCPMSKSARRKIRYRYGRKARPKEMCNWIECDRCFADDTSPVSEGSSDGSVEGSEASEEKGERGFAGLVCSRCKLVKYCSTAHQKLDWEEHKRVCVKPLSETLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLU3</accession>
    <name>A0A2G8RLU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_15174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLU3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLU3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL22485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="546" mass="60636" checksum="EB1D5DF54EEFC99A" modified="2018-01-31" version="1">MPSLVVAAGGAAVILYAIWGLFGHYLVRSPLDNIPGPPPALSFLGPVRQVNPRQAWKFWANLSKTYGPVSLIHGMLGRRLLVVHDPKALHTLMVKEQDIFTNGIAPSNDFMVLLGPGLLSTQGMQHKKQRKLLNPVFSAAHLRDMSHIFYNVAHKVRKAIVTRVPVGGPSEVLDVNGWMARTTLEMLGQAGLGYSFDNFVEDLTDPYGESVKLFFPTLSRFPFFGLIVHYFSHYMSDSTLRRFLSAVPNKSLRQIMEISATMHRRSQEIIDEKKAALRKGDDSMLHEIGEGKDLMSICLKANITASEAEKLSDEELIAQMSTFILAGMDTTSNALSRILHLLAQRSDVQDKLRAELVEARGGTGANVDTPYDELVKLPYLDAVCRETLRAFAPVTISGRVATRDTVLPFSNPVRGRDGKEMHEVFVPKRTVVLTHYQGSNSDPSLWGEDAEEWKPERWLAPLPSALEEARIPGVYSNLMTFAAGSRSCIGFKFSQLEMKVVLAVLLPKFSFELTDKPIAWNSSAVNYPTMGEESTKPEMLLKVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMZ6</accession>
    <name>A0A2G8RMZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMZ6"/>
    <dbReference type="OrthoDB" id="2746429at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="393" mass="43813" checksum="75726145CBE0A604" modified="2018-01-31" version="1">MTGFFLECALRAHSFTRLEIYEAEAILSANALLPAAIAVLTTLRHLMLDSAGTVSAAMLRLFRSRLTCAEIVYSIANPPRALKDRNAAAILHRSEDSLRALTLEYPCTAADGPSYPNMRSLTLKYMDVPTTRHLVHAFPNLAILRFYDQYYESDLDVNFEDEDEDRLERKREANVAEQREHGSWGSLIGYKGPLSVLYGLGITCPVHFLVVHEEINVSMLRAVVADAHPSHLTVRITEVTYLLEKAKAFVRLCQRFEDNLYSLELNLCLSPGDWTLDMEAVMECICNALSAAPSVTAFKIELDWAVLTSSKMPADGVFIDSDGIIYNLAITTMAREYLNGLDADAVADRLFSASKSLKTIMVVLARTDEAVVTVKRGTPEDLEVFVMLEKSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNC1</accession>
    <name>A0A2G8RNC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSI_14322</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RNC1"/>
    <dbReference type="OrthoDB" id="2755185at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0229">DNA integration</keyword>
    <keyword evidence="16" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <keyword evidence="17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="19">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="20">
        <location>
            <begin position="1325"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="21">
        <location>
            <begin position="1987"/>
            <end position="2150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="269"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="624"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="824"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1835"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2387"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2538"/>
            <end position="2649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="369"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="648"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="1835"/>
            <end position="1850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="2411"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="2538"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2592"/>
            <end position="2601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="2620"/>
            <end position="2631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PIL23015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2712" mass="299859" checksum="51C156CAC37A3025" modified="2018-01-31" version="1">MASARPAAPNDAWSDLALATKWGLAEYGRVREEEQGRRVTRTYTRALKSRGTDGANATPGARAGQDRSRGEHAAAMTPAAGGRGPPLPPPEPPATPSSELGAPQDRGSAGMQDLVLRRRTGDSTVSLEAGDRQLAVRRSKGDSAELLLQEGQEWQVLGPVPGLTPPGLSWEVLCNDEDQLGPLPPHWYINKSAVPTLPVVMKAGSSLVDEFWRDYESSSSEREDDDLQQAIAASIASAQKEARHRDLDEASDDGSQGDMSAMAIIVEVQTETKPAKPEGADGRFTTKQKQKSVPRTSEQREFLRGFVRGNTAPPPPMPNAAQRAHTAATPEPSRHRPTVPVDQPLPSYYRREASQLPDGGWYGTVPMAGPGGRGGGGHGPPSSPSDSDKSDSLESSSDGSSDGSDDLSSSSDSSDSEGGRSPSSSRRSRRKKPRSPGARAKHRRQTKERCRARKAMKGVKINTPFVWNGTPNIDLFDHWIYEVETWSFVYGLPEKLVLRLIVQFLSDKPSKFFMKHVAPSLSKWTLRALYDALFNYCFPVDFKARLRARFERTVQGRNNVQDFLRELEDLASRFPDVTDFQVTQIFWRGLHQYIRLYLIEQGLNPERTTLKKLVKHAVRREEAYETARREERMFESQVPGRTWGRFASRTTGPTPYDPSKSQARSDGAHSDKTRAGPSKSPHAQKPDNGGGNGSNSRNNGQKPPGKDARQRDKPSTGGRRELTKEKLAELREAKKCFFCEEKGHQSHNCPQRHTAKAPMGPSVRASSIRFAGLEALADRARAADDPAVHLGAVQVPVGHACSESGSDTEDEGVYFSCREYATSEDDSGSEMSFPSTEGAWYTTEDDPDDDTASEPESGNLRCTYGNWSGQWPTRAHLEDTVQQLSVMFVSAHDPQEAIDAGVDPAHRFEFYADGDCIEVTDTIRDRADWRFPFQFSVTREQLEHLGWGAPEIIQAEWNTWVDAPMLEEWGSGFPETGVADQYHPARHWLQAHLNDQLARDYPSLTGTSTLLMVEPHELGYLVVSAMDCETYFISHETIHRQDFHLRDVMEVTLEGFSGEDLRYKLQAKVRRRRRRLALMLCAARTGKPRAKSSKSAESPRDTIYAVERTAMRTKDFTRSIPKPIVVAVRIAGKPCRALLDTGSMADFMSTTLVDQLGLKKEILAKPLPVQLAVHGSRSKINCSVTADFEYQGISCKRRFDVVNLDSYDLILGTPFLFQHQVAIAWNPTRVSVGSTEPLDVQGEDIAVVSSAAAEIFEDELEKLWEELRHDAADLCQDGARAALPPLRDVNHTIPLIDESKVYSWRPSKCPEALLPQWKEKKAAYLESGRWQLASGVNASPMLMIKKPPRDDGIVRLRTVVDKREQNANTHKLAAPLPDIDGILQNVVKHKYRSIIDGKDAYEQIRVVPEHVSRTLFTTPDGTMVSLVLQQGDINGPATYQAVMNHIFAPYIGVFMDVYLDDIVIYSNTIEDHMRHVRLIFDILRREKFFLGADKMNFFAKKLKLLGHILDDKGIAMDPHKVDSVMNWKLPMNKSLLSSFLGAVGFLAPDCEGIRIPMAVLSQLASPSKSWQWTDMHQRVFEQVKATVHKWRHNRRTALNYAEGVPCINLVTDASLTGASGYISQGDDLATAQVVTFWSGKFNSAQQNYPVHEQELLAIVESMKRFRPLLYGAKFRICTDHQALEHLMRQRNLSPRQHRWMDILNEFNFTVYYIPGETNTLADALSRIYSDEPLGIVRASSEYVGDDGTGPRLELEHLRPDILRPLYTGAAAVINFEPRRSSRIAQNPKPAGAYRAMHEGQPLNEEPTELDVPMESEADLDEEDEDLQSQCEPLRFTSEPLEPSSPSALRSQPSVVSTASELGMQLPSGLHGRYAEDKFFRKIAAAPHEFPHFEYTDGLLYKKQGNAYLLCIPDVRIGSRRLREVLIRHAHSILAHLRSRKTLEYLRSEVWWPEMVGDTTEYCKTCGVCATTKSVPARPLGLLCPLQVPRRPWQYVGIDFVGPLPGSSNRHGEFDMICVIIDLLTSMVHLVPTKQTYGAVEMAEVVFEHVYKLHGLPERIISDRDSLFTSTFWRALHERLGTELRLSSSYHPQTDGATKRANRTMTQMLRQCVRPDQKDWVQRLPAVELAMNMARSETTGFSPFYLNYGQMPRSLIWESESEYPGVQAFAQRMKEAIMVAHDAIIAAHTSQVVQANKKRRPASFEVGDLVYLSTKNLSIPKGRARKLAPKYLGPFQITEEVTEGATYRLDLPHEMRTRGLVNAFHASLLRPHFHNDDRRFPGRQFHQLPGFGDNPREWAVDRILSHVGRGTEAEFEVQWSTGDVTWAPYADVKHLQPLVQYYEALGIPGVCQLRDKEAANDDSPHETSENISSIGVASMTFVGWEGASGGFEGDTGRRGSAELNAPKRWSAGQRSAPTPLESPTSVNMLPPPPQPYNIPPPAPQQAPHVIGQPAGPGVHMSDQAFSSWLMHTSALNAHLAQIAFESTQMVGRATHLTATPALAQQQVNAPLAPRAMLPPWRGGRPNTGRGGFAVGRGGRGGFNGGRGGFHGGRGGRFGGTGRFGGAGHGGGHRGPNNAQRRRGGVPGGGRGGAVAATQQAAALADRIGGPANVPAHGGQKKDRKRGQKGGQKHGREQPKDGGAGGSGGESQVEADVFMARLVARLTEIFGEAAIATEDDETVSLGGSDPGDVEMVAGPSSQGGGAFDGMGFCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNQ8</accession>
    <name>A0A2G8RNQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNQ8"/>
    <dbReference type="OrthoDB" id="3006363at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="411" mass="43904" checksum="3CEFB16B92D2A207" modified="2018-01-31" version="1">MDSRLEKWRRVRLGPRDSTLSATLLPAPTVTASQPANSSGLEPDGLVPFGYSSHTSSMHETDSDGKGNGSDGDNNNSNNSNNNNSGSSKSSSDPSTSSGLPQDCSINNLRPMVPGCQFVNDNDGSLQYSDGWSFSTSDPNGLIHTVHFTQNTGSSVSLMYNASSIIVFGLVPSGSSPPQASYSIDGADPTSPHMAATSQCVPNQQLFNSGTLAAGLHNLTIEVTTASQDQPYILDYLWVCGGGSSNNKDTSEKSTAGTETHDRTSKDKGVIVGVVLGTIALVLGITICVGMFVRRRRKRLARLQRLRLSPSPVASWLYWNSQSDERQSMFTSSEDILANNPTYSSSSGTQKAMSYRKAPPAFLISAPPSARMSTVSKATSLSRPASYDPPGLEDTGWYPRRMERAPSVVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP67</accession>
    <name>A0A2G8RP67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">GSI_14626</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP67"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP67"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="24"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="13567" checksum="8249AFA6313CCFB5" modified="2018-01-31" version="1">MRARQLARLSVRPPPRPRRRRFQLIMAGLQGYVDHKVLLILQDGRAIVGLMAGFDQKSNVVLSESRERVYSMEEGVEEIPLGLYLVKGDQIVLIGELDEATDKAVDLSTIRAEPLPPIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPU2</accession>
    <name>A0A2G8RPU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPU2"/>
    <dbReference type="OrthoDB" id="2799385at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="40473" checksum="9835F0EDA7B71C37" modified="2018-01-31" version="1">MTQFMNPHPTVAGWTPLPSSPGAGPSSPVPPPMLSVVPRASAATNTTRHHCQRRPKQAYDILGDFYHNVSDHPSKRQRLELAERVRRIPGCEDYTSTNVSGYFSRKRQTARASDEARRHPGSPALPTSKESPAQILYPSLTKGPRVIPLLEVLLSEDPNPSDEIATIWAERLGYQAKAKDILTFARLRSARKPHSPPPLPSSFSTMPPLPRLPPFSAPRTQASHLPTPSTSPEPASLPTSPVVGNTGIIDRIAAASSMREEEDELDSDEDMELDSDSDSEVEVPLSAVVAHTPTVLPSHVQHDLVTSLQKVFSQPRPPPGENDATTPRSFAQLSRWIGGQDQTATALLDEIEKGKYAHLGLKPAASSAAPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSD2</accession>
    <name>A0A2G8RSD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSD2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSD2"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="275" mass="31479" checksum="1714A4080258923A" modified="2018-01-31" version="1">MILTRIPFSHSNSRGFPLINLETISRTSVSEVRSILSSLNIPMELVLHIMAIAEYCPTLRTQRPDTVKIAAGLYHNTEACWAAKLYLVSPPLPRAPEDTLFWRVRKVTWELEGRDQGRSNQRRGEYRGACSWYDACIFRPLQAQAAEGIQNFADLTEIDGIDRTFTDPRRGMFAVQELLGAAGWTMVPHGDSNELTWRLQNNRIADSRYKRHVFEWSVDRRGVAADAKHRGSCDGEGFVEALRPGDRIGIWMRAQYRGWKCHTKMASVSVMYEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSH6</accession>
    <name>A0A2G8RSH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSH6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSH6"/>
    <dbReference type="OrthoDB" id="5308060at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF1">
        <property type="entry name" value="3BETA-HYDROXYSTEROID DEHYDROGENASE DHS-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="601" mass="62545" checksum="9B965C263C5BE6EF" modified="2018-01-31" version="1">MPLVLPTIDQIDAYLDSVEHIVVTSLSAATPDLGQVSEAINRLWQDVLRHSPQAVPASLKGLGAFEVPPPPPPPPPPRGLWENTADWVADHPWTVAGLGIGVVGAGLLVGYASPRFHRRTRVGARRHVAPAGTERRQVIVVLGGDSPLGLPLVLDLEKKGYIVVTSVSTPESVDEIESKCHGYVRALVLDPSEPEMIPFFLRSLASTMSRRFPITAAGDPHAPPTTHIYVHSVVSLLTLPSPSLAPAPAPLEHLNLRSTYSEYLQATHIVPLQVLQALLPLLRASPARSRDAQTNGLGKQSIVVCLPATDARVGLPFAGAQAMSAAATLRAVEVLRREVRAASTSGSGSASSTEAAEAMRNIKVTVVDVGAVGEAAGGVGLEGSVEEWTPGEQAAYGAAFGLALEHRGEGAHRLRRRPSGVEAFVDTVVDVVSNGRKSQRGLSVVAIRLGLGRLRELVRGDRIVGAGAGTYAAAAELPAILLDAILNLPYFLISIRNALLPIAPHVIAPAPPARPAPTSAPAPQPSAAAASASSASASEKLAEGADSEHEHEHELNSSDTGSEADVESNEGGYGSGVGESWVSLKSKGKASAESQAGTDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT92</accession>
    <name>A0A2G8RT92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT92"/>
    <dbReference type="OrthoDB" id="2765890at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="330" mass="35658" checksum="7FEAE55377434A0F" modified="2018-01-31" version="1">MTALHLAPAPVADHAGQKSSPQVQRSMQVDGAGTRDTQEPLYPPGLGFSPPLRPIACARGLSILGDGVVEYRNGSSLLDGPLVGLGLHGVAIDRALDEAQTARILPAVCLGLPWPPVVDVEHVLHWPPQVALHEERMAGPGLQLSTLDDFNLEAKNLMPLYLERACTGFSCSLCVEKASDAPGTSCEVEPINPEEYMDFTFLDEDDDPLAPSRPPAPYVEKDESDLDSLEESDTASTLIDDGSACSGSPPSPTAPQRPVYPMKDGRFCADVTLGTMMNLWREEHAPGYATRDALVALFIEASERAPPDPEPLWQPSQLSRVEERDEEDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTC7</accession>
    <name>A0A2G8RTC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTC7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="15208" checksum="850411BE14D424AA" modified="2018-01-31" version="1">MMGSRTASDNEAVEVEGVETGVGRSRPPPEVWKVNLKRSLTLPLRSQYESSRWYAPIGISSSSGKYLLCAFFSSTSFAAASASASNSKRHAMAYTLSGLCLARARSFLLVILTASAIWYFNAASKMERNSWIVPKAGSSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTM6</accession>
    <name>A0A2G8RTM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTM6"/>
    <dbReference type="OrthoDB" id="2526341at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="618"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="630" mass="71812" checksum="0A620F4DFECCADD9" modified="2018-01-31" version="1">MAPRKKTKLSNNCHGDAPRNNALSKTPKNTRRTRRGCLEIVQTLPLDVSFEIFGLLHSKDLLNLAKTSKAFRSFFLNRANSISIWKASFHQVSGLPDKPEFLSEPAFAHLLFSPFCRKCGKPGVHNPIWPWFVRYCNACIADSSIQKRCPYNQYPDRQLELVVREHGMNIFDVYWINGGGDYIHKPQLDRFMEQWQNTNGDEDQRKALLEQARVATEESWKVCGSEGFRRSWFVSALMSGSPRWTTSEMSWPRVRTAIQGEMNAIRARRLQEERETQIEGRLHELAEAILDHYVQLPKTASMDCRPTLHILLGEEECCRLVIAPRDQEVTRRDFAEILPEVCTRWRVSCAEELRSLVRGAMPAISEDVDPLELAVTVFKCERCRSSCWSSTTDVAHHYPNLLAHNCACRYNRDYAKQEEDARVRRAVAWLSRASDTKRATAYALKDAPPRTKIRVTSGIWKANDGVVRMRYIVAALGLDPTRAKRSDLEKCDARLWCRVCSPMTMDVHTWEAAFFHSHKGSGVDHDFWERVREEDMTIVRELEAKAGTLLREKAHWGCTLCRDWDGAGHEIECHLREKHQLGDFGACVEDGTVYWHLGQPHRSTPGTVCLPKPPTGSSPPAASAPALTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTV7</accession>
    <name>A0A2G8RTV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTV7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTV7"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="237"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="527" mass="58815" checksum="1509F4AEC50D5FEA" modified="2018-01-31" version="1">MSGSHPLAPTFALPPFDNANVDTILRCRDGVHFRVRGAVLLEASPVFSDMLAAISSEGEEDDRGGYRSEHYDGKPIITVVENSDVIDPLLRLIYPITDPVLKDLQDIRPVLAAAMKYQMEEATTLLKKALLSYVETQPLRVWAHACLLRLEEEARTAARALVGKELPAEAPEELQEVSAGDYYRLTKFLNCRELAAKAVELFKVDPSDIKDRPKKSPRWSRSEDPPESFTFRSRPYADIICRSSDGQDFRAHRIILCVASSTLQTKITSLLPEKPPSTSSASASKDDVLPVVQMDVDAQALGAVLESCYVEPSSFAYDCSTPQYIMSMMVAARTLGMQRLLDKMQRCSYASTSRDDPLLGYLLAAKMDFPETAKEVAWNLHHDVFSYGYLPEMESTPAHFYHSLLVNRRKNAPTNAARNAKSGALDASSCTPEAKKLKMGGLHSSRCHPWVQSLVAGNMESLRGLDRALDAFAVTPRYEDVLQDSLKEKIWCGKCEPNVRALNDMSVSWKRVYDVLCENDYIHQIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU53</accession>
    <name>A0A2G8RU53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_12933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU53"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU53"/>
    <dbReference type="OrthoDB" id="78669at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL25045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="358" mass="39103" checksum="DB3C72A5EF68B9E9" modified="2018-01-31" version="1">MLNMCYMLVQMLYGIWTNSLGLISDAIHMAFDCMAIAVGLIASVMARWPPNERFTYGYGRIETLSGFANGIFLILISVFIVFEAIQRLLDPPEMNTSQLLLVSSLGLGVNLFGMFAMGGHHHSLEVKVDPLSHLHLHPAHARLQGEGAMSPITPNYKFGHDAHFETHHSSGHAPNLHDHSHVHDHGHEGHSDNMRGVFLHVMADTLGSVGVIVSTLLIQFYGWTGFDPIASLFIAVLIAASVIPLVIDTGKVLALDMGTKEKSIRDALATLAPIEGLDSYSAPRFWPKDSANTIGTIHIQVAPSVSSLDPGSPHSSARPTFARVDRVVERVDKLLRSRILGLEELTIQVEDSSSHYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUN2</accession>
    <name>A0A2G8RUN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUN2"/>
    <dbReference type="OrthoDB" id="3364707at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="975"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1039" mass="110879" checksum="78E24A29AB8C2936" modified="2018-01-31" version="1">MPTQCNIARPANRVYHEPIDTAQRNMAHQTPSYRPAPTQSNQSPSRRVPADFTSQSLPQSLWLSDVAEFSTSPPSLSRPFPGFGQSLRAGSISSGSLSDSGQSSSRPLQRPPSRDYLLSASPSRSVTLSISGSHPRHHTPSPVPSFHTLHSSRSFGAVSPHRNSVSSVHAGGHLDLKRLMSKPAMQTSTTSTSLMHDSERSLGGPSSSRVDHSRYLTDGAISRPPPSRSAHASRERPPLNVNTVGSRSSSAPRHGYTSSPERKEPSGDSQTGRASRNVLRRRPSARSNPSTPTVSNFRPATEQTFSPPARSASIKQPDSGIPFISSPIPLVTSPNTRDLQAPTPPRTKTISSPSIPHVPAGLTPAGAVALAYKQQEQRREELAETASFNEAYQPSSINMVKPAHPERQASSGAESGEGTGRPYYTVFGGESGRLVAVGGPEDDWHYRLESRASMSPNAKPSPSPGARSLTRKVSGSLKKVAGSIKRGEREQRELPASSGDEWKPYDGSKPAPTRDPSTSSQSRLVSRTPSKASLKPINLDTAPDGKREFSPSAKLSPAAKSSPSPREGSRPFPLSKAGKGRAHEHEEDAASSKWWKLMKRISTGGLREKYTASDAPPPVPALPANLKTVPVGRKTMDISSGRGNGEEVNENGVLLQRFMRSRSSLSGVRPSLSPSSKTPPSGGSPRTSTANGSSARSPAAAAIKGRASTSGHRPSIATRSSSPGSSDMATSSMSNHNPTSSTRSSFSSYGEEIPPVPKPVGQYIISPSELSLMTKSSENVRSASLPAQQRPHLRTRSRSQTAPSEDPSFEIVHSSFEDSRFPSLPLPPRRATTGATGSPVSTSFNMDDALKGGTPSQAAIPPPLGEFGLNEPPPRPRRSARRGAPPNVEVPSRSQSMSTAMPPTPQTPRGPPQMRVDMNLLRRPSTGALSYTASRQPSATSATSPHPPPPVSASASAPTSAVSQQRSPLTYRGMESPRRVLTEKEKADKWEDLLERSARAGGTLHLGQAESRLMSDDSAAHEHEVREDESFFDSYYSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUQ0</accession>
    <name>A0A2G8RUQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUQ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUQ0"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="11787" checksum="85411B1B1C97A3AD" modified="2018-01-31" version="1">MGSTRLYSKGRVLGHKRSKRNSRPNTSLLQIEGVATKEDAQFYLGKRVAYVYRAKRAVEGSKVRVIWGRVTRPHGNSGVVKGKFSSNLPPHAFGASVRVMLYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV09</accession>
    <name>A0A2G8RV09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV09"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="182" mass="19668" checksum="DCBE28D64F771A7D" modified="2018-01-31" version="1">MAVLSTGQLPTNLLPSAHGQDRLRRLATEIDLRACVPHRDQVTISASTFKGDLQAGCGVTRSVYVPEVYGTIRMWIKEDFCEPHASLWIEFDLPLRLRCRVQVQVRCAFHPVRMLTGVMPVSSRWFISSGKLVAGKGAVLTATLTSALGELEASSISVHNEMNNITNIVAPVAVAVAATAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV90</accession>
    <name>A0A2G8RV90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV90"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV90"/>
    <dbReference type="OrthoDB" id="3359487at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="496"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="436"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="595"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="627" mass="69971" checksum="DB1F4F722F5B54E4" modified="2018-01-31" version="1">MFKEHPGRVHLSVDGWTSPNVFSFLGITAHWIQNGELRHIILDFIKLTKSHTGRYLAEKLGECLRVYGIEEKLLAFTVDNAYLNPVMLEELADIIPGTRGTEVMVRCFGHVLNLIVKAALSQFSRKCRNKPRTTNTRGMNTTDADPQDDGDLDVLDEGLNAHGDVEEDLSNAGNEDEDEDEDAVPDKDREAVDEVILEALYDDEPDFVLSQDDIKAGRVALDKITALSNRVWHNPTIRAALAEKAGEEELNSEVLVRAVRTRWNTVTLLLERALDMRDTLEQVCDMAQFNDPPGRRPPRGSRARTSRLRRFILLDEEWEILASLYDLLYPFLFVTVQVSSSGRTLVHEVIPFMDTLTDHLDKFRNNDDIPPVVRAAAYRGRKILDKYYTFTDNSIIFHIAMILHPRYKLTYFHKQNWLPEWIDRARELVRTEWRTNYKPGPPAHPATEHEASENTGKGMPSRCPGRLSAKASASASAKALFADLVGRPDAANHDALEVYLEAPPLVTVHNPLEYWTPLLKSGPDAALARMALDFLSVPATSVEVERAFSRGRLQSPGFATLLVTTQVRASTLLGSWANIPGLVDETETVNLLSGSKKGKAAPDAGPPIASTGVGARKAKEVIEIESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVJ1</accession>
    <name>A0A2G8RVJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000050">
        <property type="protein sequence ID" value="PIL25523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVJ1"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="26868" checksum="9044164C2CB1DEAC" modified="2018-01-31" version="1">MSTSTSLPLAGRTAIITGSSRGMGAAVAKRLASQGANVVINYVASAGAAQAVADEINAQGAGKAIVVQADVGSVADNTRLVDAALRAFGRIDSVVLSAGYMDNRVLADVDEQDYERHFNTNVKGPLFLIQAAAPHMKTGGKIVLFSTSLTHASVIPSNYLVYAATKGAVEQMVRVLAKDLGVRGINVNSVGPGPIDTDLFRRGKTEERINFFTGLHPQKRLGQPEEVSNVVQFLVSDEASWMNGQTIHVNGGYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW45</accession>
    <name>A0A2G8RW45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW45"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW45"/>
    <dbReference type="OrthoDB" id="439993at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08029">
        <property type="entry name" value="LA_like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12291">
        <property type="entry name" value="RRM1_La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002344">
        <property type="entry name" value="Lupus_La"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF140">
        <property type="entry name" value="ACHILLES, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00302">
        <property type="entry name" value="LUPUSLA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="6">
        <location>
            <begin position="28"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="395"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="481" mass="52536" checksum="EDB370D643AAB082" modified="2018-01-31" version="1">MSAAAVAEPTEVPKVEEDKKMADAPTETETEDQKKQRALRQVEFYFADSNLPFDKFMWTLHTANAEHWVPVKTVASFKRMREFQGLGDDWVVDALKTSEELEVDEAGENVRRRTEVQPPKGQFERSVYAKGFGSEEPGLQKKLEAFFNGYGRTNAVRMRRTDGTKEFKGSVFAEFADFKSVGVFLNADPKPSWNGEELLTMSKEAYCDMKIKEKGLTGKAADLRRQSIAGTGRKGFNAFAEMAQKEKGGKKGKGDDKPKQEVYLEFLGARIRVHEEDGGSVKPEDVPAVKGASLRFDGAFEEVNFDEIKAPLKERFARVPFVKYTKGDATGLVGFDKVLSEDDIDFVKTTLKTLSGKDVSWAVPNEDVERAFQLERAASAAKRVFSFQSRDSRGGRGGRGGRGGRGGRGGRGGGRGGQRNGGGRAEKSGDSAAAPSSTNGEQAGEKRKRAVEPDGGPNMGVRGQGVPVIQSSKKAKTEGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW89</accession>
    <name>A0A2G8RW89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW89"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW89"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553538" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="475"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="673" mass="71892" checksum="16D1A99D647F7490" modified="2018-01-31" version="1">MFSRAVLLLFVLLQSFWLSYGVTVYNQAGPMNPTATSGSSGSQATLGNVGWISALNAYNNVRLQPPALPSPMPSTSFALVLPNQAQHMSGLSIPQRGDFYGFSIEMSVVEQVIGKNASFIQVPFLNLLAALTDRGNDVRIRVGGNTQEMASLVNSLPNNAMIAKDSSVVTGSVSTGQTPTLDYTTELLYLLANVSSLVNAKWYLGIPMNDTTHLRLQIAELGDAILGDNVLGYQVGNEPDLYASHQRRPDTYNVQNYFDEFGVMVNGIHDDKQIKNANKLVAPSLQGTWKAEDLWATGYLDAYSTSISVMAMEHYPDQNCAAEFPNGGFGDIKDPQTVFPNYLTHASGVQMVQPYLNSAGIAQQLGKEFMMFETNTASCGGFPGVSDSFGSALWAVDYGLQMAYSNFTGALLHVGGQNVSYNPFTPPPTNLSLFEKWTVGPVMYSTIFVAEALGTSNTSRVVDLNANGGNEFTPAYAIYEHDTLARIALVNFMTEQGGVGSYNVTISVGGGTTGEATATPAQVKVKYLLAPSVSEKDQVTWANQTFGGRFAADGRLSGTEVIQTINCDQSANTCTVTVPAPGAALVFVSAAAQAGDDPSATQTYSTTAVTNRVATMTIDPTALAHSNGHMGDMPLAGTSKGGANSATSTHAMLSYSRLFYLLFGLVQALFWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXG3</accession>
    <name>A0A2G8RXG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXG3"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013621004" evidence="6">
        <location>
            <begin position="22"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="539"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="802"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="807"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="819"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="861" mass="94687" checksum="067D425DD1937273" modified="2018-01-31" version="1">MARLWPFFCLWLSLWSESVLGSILAIDYGADFIKASLMKPGQPFDVLLNRDSKRKIQATVGWKNKDRLFGQDAANIAGRFPLDSFSFLKVLQGAPYDSDAVFSFGAISTADTVKTERGTVALRRSDGTEWSVEELVAMQLSYIRDLAESTAGEKVYDVIVTVPPYYTQFERDAVVDAIEMSGLRTLSLINDGTAIAVNYAMTRLFPAPEFHIIYDAGASSIRATVVEFAPVPAEGKSKAGKDATQITVRAVGFDRYNGGTELDARLRNMMVADFEKRHKRSISQDKKAMAKLWKEAGRVKAILSANTEAQATIESLAYDIDYKAKFTRAQFETEARDLKHNFALPIQEALARSGLKLDDITSVIMTGGASRTPMIQEAVKAAVGAGKLAFNVNADEAAVLGAALHGAALSRQFKTKDIRITDIGPYDIQVSYQTESKAGARPRNINTVIFPANTKTGTKKTLTFKRQEDFKVKLAYKAPLLRGYPVDILEADILGVSEAVKNITEAGATEPVVKATVMLSESGFASIRDAVVTGEFKDESIAGPSSSAPEEGATADVGTAEEDTTSSSSSSSAAEASATSAAAVTKEPINLEIDVKFASIPPMSLAKKRTGRDRLKAIDAEENVKRRKEEARNTLEGYIYKLRDLLGDDSSGSPFMKCSQASERRRISEKVDEAYSWLQEHGDDAETIQYIDHRTALESLERPIVHRYKEIEEFPQALNNSQMWNWSSRMFLTEAKQNMTKELEAGTPTKYTKDELDEFEKSLKEHETWLNEWVEKQKSVKMNEDPVILSSEMRARAKVLENQLQKLYRKRPPKAPKKSSSSSSSTTSATTATTSASATGSAEETASTSGTSSKDPRHQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXK6</accession>
    <name>A0A2G8RXK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXK6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="67" mass="7144" checksum="1979BE136177C19B" modified="2018-01-31" version="1">MSRVRIATSTLVHGVALAVNTLLIGISHLGVLELMACRGSVGYGWFKVNAPREANSSITPGNFSFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXR7</accession>
    <name>A0A2G8RXR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXR7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXR7"/>
    <dbReference type="OrthoDB" id="2370221at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19899" checksum="B7921CD2C9C1A2D4" modified="2018-01-31" version="1">MDAPHPSSSIPPAHESNNAYTILVRGEQFQLSRNQIDFDSPNFFSTCFSSGFTESAKRTVTLDRNPALFALIVEYLSGYPILPLSAQAAPPLMSLAMARRCLLADAQFYGLQKLAALLATSTLNLDTRWMGYDTQAVDVRDLVKHTLPPGIIQQPDGSVVKPGSLWWPLLTTSLLRSYALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXS0</accession>
    <name>A0A2G8RXS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXS0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="13016" checksum="9E5C4DFFEA849D02" modified="2018-01-31" version="1">MKADEHPPEHIVRIGLRMACWGAPVLKRHGVAGIAVIVVVVRAKEIRRVACVEVPGVRESARAPVARVHGRRPARDAFSHRGVIEPVSFHVTEDGGESVRPFLVVDAGECVGVGYRDSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY28</accession>
    <name>A0A2G8RY28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY28"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="37813" checksum="9C922FE0072BC9B9" modified="2018-01-31" version="1">MNGAASQGAASSRPADEAAALNGAMDLLLLTTMCTGILIPISIALFFTFSRIWRTPVFILNVLALALGFANGGLTINYVRTVFSGKIPESRLVLVFMSMSFLIPICVQCVLIIRVIAVYPPWRLKRMETLFIYGTFAVLFIARIVNMTLFLNKVAQDISSSGADTITISLYAVSLPNGKAEWTLQSINDLYASVLFLLRLNQAQVFRRNGGLASVLNTGNRSYTARLQALFWIAVFNFVFPVLLNVVIVVLSFRERNILRTTDVIMLNSFVEIICVLLATVCCTETYWDYVLPPTPGIMASRRPLGMRGGETTESLASVKFATPSLSEPHFAPSDLEMAQVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYM0</accession>
    <name>A0A2G8RYM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000044">
        <property type="protein sequence ID" value="PIL26612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYM0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYM0"/>
    <dbReference type="OrthoDB" id="2803164at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="322" mass="36922" checksum="514B093C18EA23F9" modified="2018-01-31" version="1">MTTRIRPSEVTYGPAAIVAAKPILPKSRSTITLTEAQRAIMARSAADRNEQVESAIAEVYRFAESKAQYLSETCGHKSDYYLRLIFSGGVSLQKKRKPNAYNAWSHQLAKEKNGDADPGKATNLLDLQRQHREEYDKLTPQEKRDLCEALEEERDSRMFGIRVNQKGRAQDVMNTFRHIMEMCRCGIEAFIGLVRNNTEFELRPQWFFTSTPINRYLTGAIKKWDVEVIGSQFEAFSIAGCELFTFLRTVRDQAEWLKNEIRAKMNTLYADATGKKDTTMHYKDYEKVVVIDEGLTLEGWTHEVFACPSSLLTTIEPLKKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYM2</accession>
    <name>A0A2G8RYM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYM2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYM2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013809108" description="Transporter" evidence="2">
        <location>
            <begin position="22"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33844" checksum="634B9D388F18786D" modified="2018-01-31" version="1">MPAFQHLLVVSALALSVSVQAAPAGIVESREFGQATDLEARGFRHAHKGPHHGVTTHIGIPEQGHDHVHQLEARREHHPHRSHKGKHTAEGPAPTAEARDYDELDARRDHHQHRPHKGKASKGKHVAEGPAPTAEARNYEELEARREHHPHRPHKGKTSKGKHTAEAPAPTAEARDYDELEARRDHHPHRSHKGKASKGKHTAEGPAPEARDFEDDAVELEARREHHPHRPHKGKASKGKHTAEGPAPTAEARDYDELDARDYEELDARREHHPHRAHKGKASKGKHTAESPAPTAEARSLADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZK6</accession>
    <name>A0A2G8RZK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000038">
        <property type="protein sequence ID" value="PIL26738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZK6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013950181" description="Transporter" evidence="2">
        <location>
            <begin position="20"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="13044" checksum="86F7E19A4759D485" modified="2018-01-31" version="1">MHARTIFLSLALLLASAAAVPQGPESSSDVSATDSATATDSATASDSASASDSATESGSHSASRTETSGAASATATSPASHSGSASATASGKGTASHSGNSTASATGSSASAKSTGNGAAALAGGLESAVALVGGLVVAGVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZZ9</accession>
    <name>A0A2G8RZZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZZ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZZ9"/>
    <dbReference type="OrthoDB" id="5245018at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="287" mass="33458" checksum="BC775C459B5A6D1B" modified="2018-01-31" version="1">MFHSKVYPLSPSEQVELDKFINENLAKGYIQESKSPMSSPFFFVKKKDGSLRPVQDYQQLNDITIKNRYLLPLVSDLMDRLKKAKYFTKLDICWGYNNVQIKTGDEWKAAFVTNQGLFELNVMFFGLANSPSTFSALMNDIFKDLIILGKVTIYLDDLLIFTNDIEEHRTLVREVLKRLAERDLFCKPEKCEFEQPKVEYLGVLVSENRVEMDPVKVKGIAAWPVPQNASDVRKFRGFANFYRRFIKDFSAVCKPLDRLTGNAPWKWEAEEQEAFDELKRRFTDVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0C8</accession>
    <name>A0A2G8S0C8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0C8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="182" mass="19544" checksum="D9F8548AE12C5DCC" modified="2018-01-31" version="1">MPPAEMAASSAAFMLFRIRLATRTHHYIKGLAGPACDALLGLALGPTLTRSFQLLAEPSTLAPALLPPKLFPLVNKWRLVAANDRRCCLLCARLWSSRSTSSASTSEVGSERGENDAGNSTWRDSRAQPEARTRRRSLMALVLPSSRQQSWMRLAGLALALELEVKVEGGGGVGGPEDTACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0P8</accession>
    <name>A0A2G8S0P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_10488</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0P8"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="563"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="709"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL27341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="761" mass="84702" checksum="106D43A5ADA95977" modified="2018-01-31" version="1">MGVHTGSALPATSELGHAESLNSTEKDPDLQDVKEKVDVESFGVSHEEEDVDETIIKNDEDVALEVISTDDDPTLPVLTLRTLFLGIGLSAFTSVLATIYTFKPQNASVSQLFCLIIAYVLGTAMHSMMPTTGYWHYLNPGPFNIKEHTAIVIMASTASTVAVAMEVIAALDLFYNIKLNPALAIFQIFASQMIGYGIAGLLRNLLVYPTYAFYPTYISVVNLLQSLHFGGILNHKKRRYFWIVFTAIFLWEWIPQYPFPLLTAISIICLVDNGRHTFVRNLFGAGSSNEGIGLFSFGTSWTLITQGNPLVWPLRTQVNSYIGMALGYIVLTACYYTNVFNGRDILWMSQSLFNNEGGSYNQSAILTPQNTLDSSKVDSVGLPRYTTTYAISQMCYNFSLGAAIVHVLLWNWRELSRAFGKMRFMQSSQDIDDPHYQAMKKYKEVPQWWYLVLLVGALVIGIGCSYNKGDWLLPAWSVILFTIISGFIAICIGFIAATTGFSIQIKHAMNILSAFVHPGQPVAVMYVNLYGNSTAYQCLYMLQDLKLGQYTKLPPRATFAAQMAGSIIGSIFNYTMMISIVNNNRAALIDPVGTRVWSGWIIQGYNSSSVAMGAFGKELFTYGKPYYLIGFAFFIGLSFPVPFWLAHKLAKPGSWVARVAEFVNTPIISLYIGYLPYSVNGQWWSCVVIGFLSQWWARTRRPKWFKKYNYLTSAALDGGSQVILFILSFAVFGASGNAVEFPNWWGNPANLSVDRCALTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0W2</accession>
    <name>A0A2G8S0W2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_10524</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0W2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0W2"/>
    <dbReference type="OrthoDB" id="3341590at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015328">
        <property type="entry name" value="DUF1965"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09248">
        <property type="entry name" value="DUF1965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00766">
        <property type="entry name" value="CUDAOXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0801">TPQ</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1965" evidence="13">
        <location>
            <begin position="291"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="374"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL27377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="857" mass="95791" checksum="79D29A462663521D" modified="2018-01-31" version="1">MAPAGYELLKSDPEHDGLVQLAVVSRGSGSRRSLFSTQNLSPLRIFLVVPAFLFGTVFGVLAVSFLQPKLVHLDDSHSPSQPHSSQPLQRCPASFPRAAQAPAPVNLFASLTVPETVAIHEWVSSPSRNLNLTAGDKACISDNYIYRIEAYRPAKKDALAYLDHPDETSPPDRYAHVVIHHGTAKDPYVQDYLVGPIPTSEKTTMRKLTEIYHRDPIPFSARGYTTLSEIAPLLLKIMNSVSVATEDLFGGVARGLSNDTIVAAMAAPFSFDGSFRRGWVTWRRNVAGPWLHPLNFFMYVDVSGTDPEQWKLLKLVYNHQVFNSTEVFMAAYHDGTLIRLPKRPDQDPASVDWSTRKLPRPHTPRDLDHLPGPRSVSFGGLRFRVDRALQYVSWMDWGMYLGFDRDMGLSLWDLRFKGERIIYELAPQEAMAQYAGNDPMQATTAWLDRFFGMGSAVRDMLPGYDCPHEAIYLPATTHNFEGSITRERAICIFEHDSGRPITRHTGYSAGEFGSTRGYQLIVRSISTVGNYDYLFDYIFQIDGTIEVRLSASGYLQGGYWEPAQEGYGTAIRDTTMGSLHDHVINYKVDLDVAGLENSLLFTNTATEKITQPWLDDDWGQDVIQQKISRTYIENEDDALLKYPTNFQGGYSLVNKASLNRWGVPRGYAIHAGYSPIHNTVVGSKRLLNNANWARYNLAVSKRKDTEPTSSSQWNLHLPGAPMVDFHNFFDGENITQADLVAWVNVGTHHLPQAEDSPNTRTNLAASSFFLTPLNYFDYDVSMDSINAILLTAPEKAGDPWAFDDYGVGPANCVPDEVPPFEYVGVKTFGLDGQPAPPATAEEMRKSAELFHRIKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S112</accession>
    <name>A0A2G8S112_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beach-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S112"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056252">
        <property type="entry name" value="Alfy-like_Arm-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051944">
        <property type="entry name" value="BEACH_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46108:SF4">
        <property type="entry name" value="BLUE CHEESE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23295">
        <property type="entry name" value="Arm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="1239"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="1398"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1792"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1829"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2020" mass="227590" checksum="06B07F36821A4440" modified="2018-01-31" version="1">MFRTLLTPLSARFSLPSPLSARPSSGSEVLSDPDDLDPEDFARDVLIELMRNATERLKTADSLSERIEVLTEIHRIMLQDACTKDVFREMDGFLMLMSVLSTIHPTFSQETSQGESTGTELLEVTRLTFLILSESLHKHKENVEYFQASVGLESFSQATFGLISDARTVKQTMSFLTSLALHNFAWTRFFLHTSGADYEVVDHKFQAFSNQLGMIHVPEALWILYDAALLPGRDDPILRYMATKLLERLALHKHRNQCILSSLGLVRSLFERLCGGVELPKQEKQVVQKLLKRLLDHNVETEDARLMFQRAIRPDDTLDPDVLEVLRAGMKVRWPGHFSLESPAAIRVTRSGTRAFPSTGFTFMIWLWMEKIPKDKTHSLFTIGSADRTILSLKVRPDGNLDIQSAGSKEPGVLKARLSKGRWTHISLVHYPHRGSKPTIRLFVDGTMVDSVQWQYPRGDANVDRPYTIGDISPDASLNWCIASAYLFSVPLSDELPRIIHDLSPRYVSRFQATDLIRFLTYEAATALNVHLYARAEQTRASAKEVKTLINTFKNGLGISEANIIFAVCPATTQFENKETGELYDGALDGDVFIARCNGLDLAMWEIGGAAVALRLVQLAQNPHEVSRALGVLTDGLRNSWQNSEDMEQMQGYDILADILRKKCQLMNMTGFETLFEFLGMNFRSPDHSAITNAVAYRAIALDFQLWSRTREEIQLLHLEHFATLLDTSRHKRFNIKQRMGKMGIVRKLIFVLQTDWYPNEMLPFVLEALKVVAEANFSVDEAIRPIVSYLAANLQEPRGGTSSPRSIISRIDNLNAQYKAEQVFKMLVSILDNPVMFNKFTAALPLTRICLLLLGDHPSPLVATLVLRMISTALGISTSFNRKFELVSGWNVLKLMLPYGWDRSVQDAAFDILLGRSRDKKEIVPTVVCPYIVPTIFSSLRMALDSSRISEDAEALTTATANAEHLLETLIDTHSTSPTFREVFRSHAVTQSFIDAYKMYSTSVQHSAMIDQDTVRVLEKLSHLGLSIALDNAVAVNQKQEIMDVLQSAESLLNPRATQETSVDTATIVGTKSRRRRMASIRLSMQLGESAVKRSIIRIHDWRKSVVITERKRLRKTVLDLREHNRQVASLTDWTTVLTTERGLWAKSGVMSRWRLDETEGPYRVRKKLEHDDDMPTSKVDQQLIGDVSVELDSQSVMQLELPPWSESYELTVVMEEDDQLGEEIVDDKHRRVRHELEPGDVIEAVKTVARISGVDSSPGLLILGRSHIYLLDGLVENDDGEIIDAHDAPRSLFFVPGSIMDLDSHQRAQRWQQDQIMSFSDRTFLFRDVALEIYFRDSRSLLVVLSDRKQRREITGRISQIIGRTGNDPGSAGLARSPFVGRLSSKVASAFSAKMVSGFSSAELSVAQRKWQSREISNFTYLSILNQVSGRTPSDATQYPVFPWVIQNYTSSKLDLSSRETFRDLSLPMGALTEARREAAQSRYENLKSVEEKPFHYGTHFSSSMIVCHFLIRMEPFTHMFKTLQGGDWDLPDRLFIDMKRAYTSAAKDIRGDVRELIPEFFSCPEFLENSSNLDFGVLQNTGERIHDVKLPPWAKRDPFLFIVMNRKALESDYVSENLPQWIDLIWGCRQADPESYNVFHPLSYEGAIDLDSITDDLEREATVGIIHNFGQTPRKIFSSPHPSRNMHGNSALPIGIIYGIAEDYHLLTQGSKPLKDLGPEQPVHDLILDLIGQQVIPCPEGTLCVPSRPHEGISWDCSVGSTGALKVHLDRKVSQVIESAFCSCATYADSDTLITGSTDNMVRLWQITRNDRNREQPVTLQLTHLMRGHTAKVACITASRSWSLIVSGSKDGSAALWDLNRGAYTRSIWHGTEPSSEVHLVAINESTGYIATCSRDRLWIHTINARPIASLDLTDAAPSPLYPPVTSMAFLERDYCHTGLIATGAPDGTITFRTWNTDSTPEGEKAQWEFVSLKTLKVKSENRHRRAIPCVTVLKFVGESLYHGEDTGKIFGWELPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S136</accession>
    <name>A0A2G8S136_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S136"/>
    <dbReference type="STRING" id="1077348.A0A2G8S136"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="26"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="254"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="507"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="696" mass="76794" checksum="E85A34C8CB0B0A55" modified="2018-01-31" version="1">MSTLGKRKEREKREDEQDVQEKHHGSTLFVSNLPYTATSTDIKTLFSDIAPVRSAFVVLEHGTGVSKGVGYVSFAIREDATMAIDKISKEGITLDGRSLRVQWAGSKNKDHEQDEQPKTKAARSAPRPARPTGPADPLAIRTVVISGLPGGIDSKTLWKKVRKLPGAEKVEWPVKLDGGQEDSTLAHAIFESPANAMEAVNKLHAHVYKGSLLSATLKKRLDGLAKAAKSKPAKPSSSSSPHKAKSGPAPNRNSRLIVRNLPFDVTEQDLRAIFLPFGPIHSVHVPLASDAKHEHDEDATKPEEDAEKPRTETQTKQRSKGFAFVWFLSRKDAEKAIEGCNGMIVEAGMAETLVSDKQKKKKQRREEKKLKAKSAEEEGEAAVGEEAEEEEGSHRKRTIAVDWALSKDKWEAEKAKLEEAQAQEGGEDVEMDEEDGQSSNSEDDEDRSGSEENDDEEQLGVHDDDSEASGSDSDSSDSNPGEDDEDDEDDEDEKRAKPTLPAPEVGTTIFIRNVPFEATEDELRTLFRAFGPLRYARITMDHATGRSRGTGFACFWNKEDADKAIEQSDILRAETVGNEPVVTKKNPFKLPSLLTPDPSASIARNLVLHGRTLDVSRAVTRDEASKLKEAGERQREKADKRNLYLLREGSTYLSACTLLLLYDAPPCSYHANPVPWHPDSHPPEQPCCRPAPTRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S150</accession>
    <name>A0A2G8S150_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_10647</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S150"/>
    <dbReference type="STRING" id="1077348.A0A2G8S150"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000015">
        <property type="entry name" value="Synaptobrevin 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL27496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="222" mass="24662" checksum="C1DB1E261D9CAEF9" modified="2018-01-31" version="1">MSLIHALVARGSTILAEHQGGQRDFSQATQTILSKIPPNNSKLTYVWEQYLFHYVSEGGFTYLVMADDAAGRRMPFTFLAELQQKFTSYPSASSSSLSDPPAYSLQGSFGPVIAQLMTQYNTNPPTDELTRAQTELAQVKDIMVQNVEQILSRGERIELLVDKTDTMASQATAFRRGTRTVRRSMWWKNTRILALSIVVGLVLLWVFAAQFCGAGLNQCGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1T0</accession>
    <name>A0A2G8S1T0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1T0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1T0"/>
    <dbReference type="OrthoDB" id="434695at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="752" mass="83858" checksum="BFC35EACD29510A6" modified="2018-01-31" version="1">MADASFKDVPEIFEVELGESLTSRTESLSTFRELGPPDLVHVLKSTGRSGQRDLGSYHYVSGVDASSSASLAAYINSLTYNIEEEAGWFSKGTTWKVKNGCYCCFNAFSRVDVRVDVKIPGGVQAYVVDLRGERHEATPEIWQETFLSALLRAILYSDDPAYWLEAYRKLDPITNPEGELRFLQAAEALFLKGWQVGSDPEIQVATVVSNHLTAAIMKYFGDSGRFQYAANLFEKITAKEPEVASLLAKSYLGMNEEVKAVQIMASAIKQTPQSYTLLHVQCEFLRSKGKYEWAVKLARQAVNCAPSEFVTWEKLTECYIDLGQYENALLTLNSCPMFTYNGRDAHRNLTPARVHLPPKGTIVEILPERIKTEDDEADPALLRLPAPGLRGTWARAYALLTRLVSQIGWDELLKTRSSVFVMEEEYRMQKAHADSQIHSPSKVIHEDGSVTVTSPKRGVSLDDDASTRGIISPTASTPDHAGQSEKPEGEPESEADSATLASTNGLPTIRISTESAREEKAAAAAAAAAATTTNGHDEAMDAKENGVKENAGDALEKPVQAAENPEGEGGQAPSQEPFSFSNKRLCERWLDNLFMVLYEDLRVWTIFRAEVAHFKTQHVAYRKTGLEWEILGDLGIRLHHKEEAKEAYQRCLDTPRYSSKPWSKLLDMYAEEGDIQRSLQVGVRVAAYQWGEYAEMTYPTQIARCFFKLGQIHGHAKIQWSLLSMGLPEPVMKIMESYLAYGRTFKVEGYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1Z1</accession>
    <name>A0A2G8S1Z1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1Z1"/>
    <dbReference type="OrthoDB" id="3355826at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="46"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="294" mass="32446" checksum="78A53AA578D44CB9" modified="2018-01-31" version="1">MPVDWTNKEFAEKYGPAEAMTGPFGRHLLTQCGIDRADGSEDIVLLDNATGTGIVLVHLYDVVPPAAKARLQVVAGDISAAMIEFAKARIEKNGWQGITAQVVDATKMDLPSDHFTHVVTNFALVGIPDPRAALREVRRVLRPSGTAAFSIWRSVGWYDVVRAAVESIPNAPRYPAFEEIAKAMLKDQESGDEAAWTSPAYFEAQFREAGFEDVKTVQHKNQTRYGSAEEYVKVFTPMTNLVLPKMWTADERVNVEQNMVGAVLGELKRRFGDGEIVLDWEAYCVTAKVPATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S237</accession>
    <name>A0A2G8S237_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S237"/>
    <dbReference type="STRING" id="1077348.A0A2G8S237"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="284" mass="30258" checksum="9050CE66BCD282E3" modified="2018-01-31" version="1">MAVWLITGTSTGFGNELTKIVLENGDIAVATARRPEALAALAAQHPAAADRLLILKLDVTQEQDVVAAFSAAKAKFGRVDVVANNAGYGTLGEIESTPDADARAMFETNFWGAARVSREAVRFFREENPAGAGGRLLQFSSVSGFQGFPGTGYYSATKFALEGFSESLASEIDPAWNIQVTIIEPGGFVTNALKGDSQWAPTHPAYGRPELPAAAFKRVLIESPPSGDARKGMEVVYKLASLKQQPLHFPLGKDAVAGARAKTSSFLADTDKYASWSEGLERDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2E3</accession>
    <name>A0A2G8S2E3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2E3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2E3"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="459" mass="50044" checksum="73B9751E33019E53" modified="2018-01-31" version="1">MSVSPPIRRLSTSSSSREDLIYQYEAEEERIINILSRKLEQVRLSSANAFTELTPPSTQLREEKIELENVLEAESESHVNRLSRELSALRLAQQQQQQAGPSHVNGSGAASPQDTRTAPQPASLLSRSNGNPSQDMILDALRRENEALRSRLVETEQDFIRISRLNEVYREELIQHRRRLGLPVDSLIGLPQSEPFSQPMHRRSSTGSSPSSSIHIPSYPSHPIRHAAAVPIPRPPSQIRRPSNIISSESTTPLSHSPSSTSTSPFPFSPVTTSPFPASYTSAITTLTTPPSIGSVAVSPATFAAGGARMLSYPSVPPPSLSSSFGSPSTSLHHAGPMSLASRDHDGTPSPVESFHSRRNSFNRRGSFERRVAETGTLQRRPPSQSQSRRESVERGVRVAETGTLVPRNRADSFGLPVHEILEDVDPDPASAPSSVRVNGDRRDGEGRSTPARTPQPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2N0</accession>
    <name>A0A2G8S2N0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2N0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013735367" description="Transporter" evidence="2">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="18665" checksum="CCABAE12541BD993" modified="2018-01-31" version="1">MFVAIVILGELALTVESFVQPGLSHWKEFSYRLTSTALGMAITADVFLTTVLTVVLHRSRTGFKSLNSRNSPSGYTKDDFKGNAYEIGAVPVNDLSTHSATTLSGNDVSTPSEHVLHIRVTRQTGTSQNGSFSGDVTLIDRKAEPSIELCNLQSSADSLKGNAAPSPDGLFHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S395</accession>
    <name>A0A2G8S395_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_09665</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S395"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="74"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="699"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1495"/>
            <end position="1516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL28253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1516" mass="173132" checksum="FF248A31BBC17281" modified="2018-01-31" version="1">MEQTGEYVRLVGLSATLPNYQDVATFLRVDTTKGLFYFDASYRPCALQQQFIGVTEKKAIKRYQVMNEVCYEKVLDQAGKNQTLVFVHSRKETAKTAKFIRDMAIEKETITQFVKPEGATREILLEETNNVKDPNLKDLLQFGFGIHHAGMSREDRGLVEELFADGHLQVLVCTATLAWGVNLPAHTVIIKGTQIYNPEKGRWVELSSQDVLQMLGRAGRPQYDTYGEGIIITNHSELQYYLSLMNQQLPIESQFVAKLTDNLNAEIVLGTIRNRDEAVQWLGYTYLYVRMLKDPVLYSVGVDYIEDDPTLVQKRADIVHSAAALLEKCHLIKYERSTGRFQSTELGRIASHYYVTYSSMATYNQHLRPTMSQLELFRVFALSNEFKLIPVRQDEKLELGKLLERVPIPVKESVEEPAAKINVLLQAYISQLKLEGFALVADMVYVQQSAGRIMRAIFEICMKRGWAVPAKAALDMCKMVERRMWGSMTPLRQFKGVPNEVVRKAEGKQFPWYRYFDLNPPEIGELIGIQNAGRLVHRLVHSFPKLQLSAQVQPITRTLLRIDLTIVPDFRWDEKVHGAAESFWILVEDVDGEIILFHDAFILRQRYAEDEHYVTLTVPMFEPVPPNYYISIVSDRWLQAETRLPISFKHLILPEKFPAPTSLLDLQALPLSALHNKEFESIYSSTIQTFNKIQTQVFQALYTTDDNVLIGAPTGSGKTICAEFALLRLWSKREQQRAVCIEPHQEMVDQRVEEWRKKFGNLQGGKEIVSLTGETSADLRLLEKGDLIVCTPTQWDVLSRRWRQRKNVQTLGLLIADEVQLVGGEVGPTYEVVISRTRYVSAQTELKTRIVACGVSLANARDLGEWMGAPSHAIFNFPPSARPLDMDIHIQSFQIPHFPSLMIAMSKPAYLAINEYAPHKPVIIFVPSRRQCRLTADDIITHCSADDDSNRFLHVEEDDLAPHLEHVTDVGLKDTLKHGIGYYHEALNKQDKRIVERLFQHGAIQVLIASKDTAWSLPVSSYMVIIMGVQFYEGKEHRYVDYPVMDVLQMMGRACRPLEDEKSRAVLMCQQTRKDFYKKFLAEGLPIESHLPTHMLHDYFLAEIAVKTIENKQDAMDILTWTYFYRRMTRNPNYYNLHDVSHQHLSDHLSELVENTLNDLVNSKCITIEDEMDVSPLNLGMIAAYYNISYVTVEVYTLSLKERTKLKGLLEVVSSSAEFESIPIRRHEDVLLRRIYDRVPVKLDKADFETPHFKTFLLLQAHFSRLSLPPDLAADQGLVLEKVLNLLSACVDVMSSNAWLNALGAMDLSQMCVQACWETDSPLKQIPHFEPEVVKRCRDAGVETVYDIMEMEDAKRNNLLQMDARQMRDVATFVNSYPTLDVNFELAKGEYTAGAPIQIQVSLSKDADEDMDEPSEDDETVVAPFYPKKKLANWWVVVGEPKTKQLLAIKKVTVHRSLNVRLEFSLPQGEHALKLYVICDSYLGADHDIDIDAIDVAEGEESESEEEESDEDAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3C2</accession>
    <name>A0A2G8S3C2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3C2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3C2"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="244" mass="27481" checksum="AB1BF2745170B7EC" modified="2018-01-31" version="1">MSDKRITLYSALESPYSQRVLLALEEANLPYDVIEFDLADKPSWFKEKVYPTLAQVPYLVYGGPKLQPGESPSPELPQLGESLVILEFLADTFPEARLLPADPFLRAKGRLFSRAVEEKYRPVFLGLFFQQAPKETLYDVVEHIQGLLPPTGFVAGEWSIADTAFLPLYLRTLAILELNHAISQFAPGFAAEVLATLKESPRFARIRKYVEECMARPSAAKTWDPVLVKAKAVRYFELKMTPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4E7</accession>
    <name>A0A2G8S4E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4E7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4E7"/>
    <dbReference type="OrthoDB" id="3225203at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="32025" checksum="900A5297C31500B3" modified="2018-01-31" version="1">MAANDKSLRIASRLVCRDQWLVTHVDPSWPVSTLKLFLLRKFSGIVSDPDDNPRAIPVSPRKARRRSLSPITGSEDSGDLDFDDDVNITKAFTDAHRYKYTARPSTSSIADSATPPADPKHDPNAYVLLTFSTTQILEERFSLSWYGIHADELLELHPTSVSFVSLPRGTLDAYIAPYFAARVWALRIVGHGSDEKENDGPDTGRQSVRDKREKKKIAVEWKERWAIIHQGMFSLCKERHEAVEFAVLAREALLPSASSFLGTSSSNALCTGSESVAPSHEQCKRNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4G4</accession>
    <name>A0A2G8S4G4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4G4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4G4"/>
    <dbReference type="OrthoDB" id="2746623at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="316" mass="35277" checksum="9931B6397B617A77" modified="2018-01-31" version="1">MAQNLNSPTGKTIFIGCNLDDTIGALKLRIQDKEGIPPDQQRIIFAGKQLKDGFTLRDYNIQGGDSSVIHLVLRLRGEKPVIYLFPPTPIPDATVSVTLDPRWSFSHVYPLATPKRLDHGWQCIDWTVSAQPDGTLVEKDTGLELSYLFWEADSNASLPTSPPLSPADGALAEYFDPVYPALDCDSPTAVLLPFAKLLPYLDATLKKLSLHTAARNDFITYWLPKLAKQPFVALRFLPQAAYERAAALEVHPKPEVVTRVFMLFRGVSIEDAMQSAWSDALDRVGEVDWPKVVGIKDEAWDESRFRVLEWGAMEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4L2</accession>
    <name>A0A2G8S4L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4L2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="240" mass="26823" checksum="2AACBB7CED3EE08D" modified="2018-01-31" version="1">MDAHIRTLEDDIQRKESNLASLEEVMNHARNDLAHHENTRNSMRIAVCTSYYMVRTHQGPEDPLKLTGAWLMSQAMATFFFPIVPAVLMAVDATSMRVAIEERQRTVCTIEGRLRALSSQLDSRRTQLTAARAERDRVSSLVSQLERRVDDLAAETRQLEAERETLAYLPVRINDCLHALAGNSGLTGSKATSTRNVILGIKSVVEALGSEEMFTGPLKQLNDTIQNLDGRDQCIADRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4X8</accession>
    <name>A0A2G8S4X8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4X8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4X8"/>
    <dbReference type="OrthoDB" id="2729416at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="221" mass="25525" checksum="BF3F05D3CC30E7C5" modified="2018-01-31" version="1">MSHSVPADADPRLFWNGQYLLEDDPNDPSKYSKAAEEAQRAKWLALMANRAPSKTLSRELIAKNGSKPPLYHYGIPFTDQYMLEYAKRHHLTVKLLPGAMKFFGGKPEFAFEDISREDEEDEVFMSQLLSAGCSAAVRHIGDRCDIPLHLARPFSLHWDGMVSLWSNYDINERSLTWIRSRERCENIMAKLKEAMYEGGEENEIEWWYEWNNDVGIFTSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6C5</accession>
    <name>A0A2G8S6C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6C5"/>
    <dbReference type="OrthoDB" id="2752750at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="77" mass="9026" checksum="D8B497CC4EC287C4" modified="2018-01-31" version="1">MFLQDVDRLEDIPQIQPSTFGFDLQPTKENIVTLALTLEHNESYFKLMKVAVEGLLTYMAKERQFLQEKMENTIFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6R6</accession>
    <name>A0A2G8S6R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6R6"/>
    <dbReference type="OrthoDB" id="3260031at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="73" mass="8435" checksum="B4DAB7F9B51BFD59" modified="2018-01-31" version="1">MAQAAKQTMPVRGEKTCPKFDKADPTSLHRYFDDLEALFVRHSMPDADQDDWKVRKELAVCYLPTAVEYGWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6V5</accession>
    <name>A0A2G8S6V5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6V5"/>
    <dbReference type="OrthoDB" id="2757906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35480" checksum="AA1AF76F1EA92497" modified="2018-01-31" version="1">MAAHTLAARSLPELPIEVWQLVMDAVWDATTYSTFYSNQADYRSWALVSRAWRTCAQAVLFRTVELSDPVHLRRFAALLGNAPHLAVYVRTLRAYSRDLHTHDNVLALLPAVLPGDVLPNLRSLLVTRVTEQDTWHPHASRPPSDKELAYMPLSTDSAENGGGSFTRGLEAHFAGVSELYLSYVTFETFGALAQTLHALRNLRLLSCLEVRWRALGAMPECLAWKGGDEGKGQGQEQGFLPKLEDLTIAYMDLHGVERLLSALGGRSAALKGLYIDCPHYCPVTFWDPRKPPPSRHTFRHYIQKLTLQRNQCFLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S779</accession>
    <name>A0A2G8S779_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S779"/>
    <dbReference type="OrthoDB" id="2537258at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="95" mass="10487" checksum="E479FCBCD1968501" modified="2018-01-31" version="1">MSILPSPPHLPLTPEPAYALNPAPRTLDSNMRTILSSSWRVLEQPPPPTLREILEAYKAKGDGDREMLLAMLNAKSSEDQVGSLSRIHSTCHLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7K3</accession>
    <name>A0A2G8S7K3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7K3"/>
    <dbReference type="OrthoDB" id="3254429at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuclease H1 N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="597" mass="64224" checksum="5F5B1A39D493D778" modified="2018-01-31" version="1">MDSCTCPSAEAMEKKEAYVVLVGVKPGAYKEWEDASPYVIGVPQSQYEGFEDMAAAIEFYEDAHMKGTTRTVKKPPSTDEELEEKARRNRRRRGEKERQPRRRDDSSPSASVQAPAPTLRGSSAGKAARDAQIAAALTKGRKNWIGPSASSPSVIPGERGQSDELSRHAARTRSATEPAYHVQPEVQQSRTVPESPRTPPRHRFERRTIELPQLEPELLPRMPEMETASDCESCGLTSDILTYETQMRNRFTDSPGLLTPRYAQSLSYASSPSSSLVLSDLCTHLSSPSSCGTRYFPEDWLARQGYGQRWESNDREGHGDDGSSVLSLSKYATTPNAPEEGIIELEDGVEDTRGVPSPSPTCAHSRAGWSTGKHLSSCSSANPKAKMKARSSAMPPPATPTEAISSLNTTLTLRRTSKNPVGDVPVRPLPGGLPCACEHPAYVCINCGRRPRTERSLAPSFASTIATTASPVLFELSPLIASGMPASAIPSSVMVSTRSSSSRSHAKHTPVVGPSETRAYTRSPTARIQESLGMMSFSEAARGVGAEVVVHDVSFDPRSPIQRGTNIPVGTSGSAVRPSPPTAPVPMGSLGLLFPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7K5</accession>
    <name>A0A2G8S7K5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7K5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7K5"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23335:SF1">
        <property type="entry name" value="CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1152"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="5">
        <location>
            <begin position="578"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="768"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="801"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="852"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1051"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="886"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="901"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1190" mass="128576" checksum="524CDB05E1F4F9B3" modified="2018-01-31" version="1">MSSSSTTACSRSPSPSPTTPEASDILDPIMSQEDLSAWCKSLPNAEFLVNGQLPFGDHPRKVEDRPTLNLEDLLQEHVYEDATPAALDLPADPMFCPVTSPASPNTSITITKPIPPPAQIRKDPPALQRVVFPEKESCASLPIMFPGLPEGGTKSRVETQIRLTVDLAHASSSSGEPFRYDKVGSWKWLRLPKGTTTKKRTRKEGKVDAPTEESLYLTAEITCATPPHTRVTVCSSCQTREAKRVARKIASRIRPARSDSDSQEEPLVIPGKGKHEDTSNILQFNCPEVLDFSSGSVILPVRITCYCRHHREKVGFNLHLTMLDHTGRVIGTGTTRPIMITDDHKSTGINAQKPTSEFGARLDWTVAGTDSQDGAPKRKKATNPSDRKKRPRRPKPYDTDTRVLKLYRQSSSGSLHSPSEMTSAFATRASSPLQHTAHSPPLHVVTSAASSPPSSFSFNEHPQSSVSVTSDVFDSAASTAVASPHLSAFESNPSIADFINSNFNVDVTMPDCHELEPSVPSFPDPSHSPFTHHPPPSIPAPTPAVEPMNLAVPVPAPAISMPYMLFKHDPPPPISLPLPRIHRLIPAAGPTFGGIEITVLGANFHPSVQLNCVFGSTPSTSTQRWSDNTLVCVLPPSVTPGQVHVWFEGLPKEEDGTPPCLFTYTDETDRALMELALQVVGLKMTGKIEDARHIALRIVGNTGGPEPEPHAGMSAGGAMQLSSHLLLGRAGDNGDFEKVLLDFLALLNLPTGRAAIPNETSISKQTSSGQTLLHLATLAKFPSLVKFLISQGIDIDARDNNGCTALFLAALTGSTECARALVDAGAALDVVNAAGKTPAEVGPTGFFDFVASESEPSSEGCDRDSDEAAWGDAEEESDNEVERQTTLRRRRGRRLSRTLKPRGSASATAVEVSSSPESDHKPPSAAAEKKAIEAGLAAADDKQAATFVEVLYRTLAQLQNPQGMIPNMPNIPYLHMPNLPGMPNWGALPQIPAVFPVLVPIPYLWGDRRARGGADDKDGPEPGPEPRFGFANAVDFKSFWEKRMQQMMARVDDGHDNPPPAYTPRGTDAATFDPDAKAPILEPEAQSSAVAPQPHPDAEAETRPVVPTPAPAPRPVGYDEAAVPEEEVELYSYRPARKAPRWAQKKHDRMLVLFWIPILIISFAWAFVHALKIALHATKALVMIKVGLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S850</accession>
    <name>A0A2G8S850_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07864</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S850"/>
    <dbReference type="STRING" id="1077348.A0A2G8S850"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="46005" checksum="D721F0443CA1FC94" modified="2018-01-31" version="1">MMGLINQATSKMYKPRASDEDKVPDDTEPDDTSILDENEGSIISSLISQLRVGMDLHKVTFPTFVLEPRSMLERITDFMSHPDLLFGAETCNDPEERFIRVLQYYLAGWHIKPKGVKKPYNPVLGEFFRCRYDYPDGSRGFYIAEQVSHHPPISAFYYVSPANKVAVIGELRPKSRFLGNSVSTFMEGENRVYLLGRPEDNDYVISMPNMYARGILWGKMFLELGDSCTAKNEATGHYAEIQFKTKGYFSGTYNAIQGRIRRGNSDVGEVSGKWSATMEFKSSKGEKRVLFDAVKDGQNIAPKWVAPEDEQEPNESRRMWTRLTRAIVAKDMDAATEAKTAVEDAQRETRRNLEERGDTHVPRFFRLKDGRWMPKLALPTDEQDAVAAVEKFMWPTLPPSYGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9A0</accession>
    <name>A0A2G8S9A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9A0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="163" mass="17776" checksum="51238B9048A44F7D" modified="2018-01-31" version="1">MDSSYFTAQALYQFGARALGMGHGQLPQRREMTSGSSEADSLDSSAMDIEPSEPTGRHFGVDAGIGHDGFYAKYDIALNPRRILIPFIPRSKHSTSEYVSRSHPLPFIARRSTITQSNVPRSKYSSFRICKGPLEGDPIPSSARFESTLARDGGEAIGGFSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA94</accession>
    <name>A0A2G8SA94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA94"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA94"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10546" checksum="B8C0E579D5511084" modified="2018-01-31" version="1">MIRKLNKGAVRVIVNTTHGKIIDELEAALIRALKDGHPEVNNTRLLEFPNATLLPHMGTETCDSQKKMDVRALTNLRDYLMTGKGSDIIPEHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAQ8</accession>
    <name>A0A2G8SAQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAQ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAQ8"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002212">
        <property type="entry name" value="Zinc finger protein 672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="168" mass="17973" checksum="356CD70710F7A12A" modified="2018-01-31" version="1">MSIYCNVYTTTGSPHDHAAYAQQGPSLVSSAPPSQSGYLYASSSLPALPLYPVPPPTFRMGPQHKNQLATSGWTPTATESSPTMAITIPHNDRLAPATTASTSGRPSRTTRDGYGSDQGGERTPPSGGSHPPKESKKKMHQCMMCHKSFDRPSTLRKHLLVHTGEKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB62</accession>
    <name>A0A2G8SB62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB62"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="162" mass="18390" checksum="724E2F9B7FC62139" modified="2018-01-31" version="1">MREQGTPNPDSKRRKLASPTLPTPTQLAPQPERQMGYVKDLSQAINCLTNHTLYLKEKVKCIDGIDGDVDALLQSINNLDDDVEAINAKVDLIGDEVAYATKEIRNTRNEISKLKDLVENMDAQWEQERELRRMCKADEQQRFKAMMANVDALVAHFIGHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBU4</accession>
    <name>A0A2G8SBU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBU4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBU4"/>
    <dbReference type="OrthoDB" id="420046at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="297" mass="31361" checksum="F3616659A1EEA0D0" modified="2018-01-31" version="1">MPPSPLSVSTSSIVTNCTDDPSADMLPTPPSTHTSRSTSPVCPGLGPDADLVTDADTTEIPSAGKKKKKKKAKKSASKAREETAGGNTSGNANDEERDRPPVLCISRNKHWRYISSYHGPWLQLPLELLESLLVLNLDPATLSAADAKLPPLASHSNSSSYTNGHGHAHNHLNGHSHAHQKQRDRGFASLADYSPPDSPRNTFRHAPTPTPTPSPPRRPARRRPRPLDPGVFRSVTHIRRLIDEAAELSVRASSGLSAAALGSMRGAGGMNGSAWATAQSLGLGMNPLGTGAGGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC28</accession>
    <name>A0A2G8SC28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC28"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC28"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="34"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="368" mass="39810" checksum="A9E57BB5736F7019" modified="2018-01-31" version="1">MDKPENPHLLHVLHQHAETNPFSRPGTPGHHAVQIGFVGLGAMGYPMARNLAKWRKEHVYGSIPVLVWNRSKSKVDELIKETGEGLVVAADSVEHIANECDVIFSNLANDEVVRTVYNQFAKALESFQASSPTKSKIFVETSTTFPTLAVELDKLISTIPSAHFVASPVFGAPAAASAAQLLIVMSGDYRSKKEVAHILHPAVGRKVVDLGGNVEKAPTFKLIGNSMILGSLELIAEVYTLAEKAGIGAAPVHQFIKDIMPAPPLISYGDKMLHDKFDGTKGFAIDGGLKDSQHIRRLATELDTPMPALDAAHQHMLTARALYANQVRLGQAQFDVLDWSSLVAGTRVAAGLDPFDSSKQHNKPVPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE41</accession>
    <name>A0A2G8SE41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_06723</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE41"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE41"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="245"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL32019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="553" mass="62125" checksum="46B6300E55E350CD" modified="2018-01-31" version="1">MADPQPSQQPPSQDPPQVPAADGEASKGPSKSELKKRAKEEEKARKAAEKAAKQAELDAQKAAADVDFATEFYGKLPLNQSQSRPGRKRTPVACLSPDLDGQTVLVRARVQASRAQGSKMVFLNLRQRSDSVQALLILAQGKVSKQMIKWAAGLQTESIVLAEGVVKKAPEPINSATVQDVELHLTQLHLISGLDTKLPFTVEDANRPEQTQQTEEDPEYKRVLLDTRLNNRVVDLRTETNQAVFKLQAGIGSLFREFLEGQGFIEIHSPKLQGAATESGASVFEVSYFKGKAFLAQSPQLAKQMAIAADFERVYEIGPVFRAENSNTHRHMTEFIGLDLEMAIEEHYHEVMELLDGLFLHMFRGLRQRYAKEIDTVRKQFPADEFKWREGPEGTLKFSFKQAVDLLVDDGVPREKLDDIDTENEKRLGRIVRAKYDTDYYIIDKFPMALRPFYTMPDSEDPTVSNSYDFFMRGEEILSGAQRVHDAALLAEQMRQKGINPESMKPYLQAFQLGCPPHGGGGIGLERVLMLFLELNNIRRASLFPRDPKRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SES0</accession>
    <name>A0A2G8SES0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SES0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SES0"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="263" mass="28413" checksum="5694BC1EF2DF868C" modified="2018-01-31" version="1">MPRHPKAYVRPAKLSEASEITDVLTRAFINDPTMCFYGGVPALVKDPAHPTLAEQKTIQELRVFMAAMVKIPGLVRGNIDVVAIPIDHDASSAKPESKERIAAVAMWLPPGVSLDFSLATMLRAGALKIAFSWGLTSVKRLGGDYTAAVEGSLAREFKAHNLPRPDSWHLFMIAVDTDQQGAGYSSMLFREGFHRASPSPCHLTASKPKNKDIYEHFGFELVDTHVVGVGEVNADGIKARHDAAVGVPGFVMIKASLKITIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFM1</accession>
    <name>A0A2G8SFM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFM1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFM1"/>
    <dbReference type="OrthoDB" id="3254160at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="998" mass="107523" checksum="602245439CECFB27" modified="2018-01-31" version="1">MDVDVNVAAFAQASQGLVHNGAVPILHYLNDLALFHPVASTSGGAPPPQSGTTQDIEPTIPKAVARIHQACQQAFGSTQPLKFDFEEDVLTHGKRCTLTITRPDGAIRTYASNTLYGRKYDAKASVCTLAISDGALDFIFDESSTQPSSSAVAFQHSNIPLDMDDFVKEIEQCCLEWASGRVKPFWLNISEPKFGKTHGCALRIRLGPRNSRVYSVNTVYSSIPEARKACAEAALADGVINFIRSWVPSDDMDIVEESDPFSAIGLQQFFDSLPKPFPETVAGRSATDINGPAWLNTTIQSARGGKLVPNFIWTSDARHNLHGCLLRLERPGEVRSYLVEARFVKRMEAKAAVCLLAMSEGVGDYIRDVGKAVKDRLSPATRKHVSEVLQPLFNAEYRKVRGPGIQPAIEFDQDMDACGATMVIELAPNPGPQEVRRYTVPTEYCNRNDARLAVIHRAVQEGVIDFLRLQGNTQPSGSVPYAPQQEPSFVNRKRKNWDNGNSSGYSNDDGPRSGDDWSNHNDFGPSSAGGHFRGGWQNKKQRTGDTFRGGSGLDSTHSFRSPQTQSYGNSGPRGGFSQRGGFRPAWHSEQSDYVQPRKQGWNWNQPAVFRPPPPRGGFGGQFKASPRGGFAGPSGFVPRQQPAPVPIPPPAVQYPTIPMPSQQQSRPLPPSYPYPGGGAVPGNAQSAQAASSGAVPHAQHIPIPYQTPAPQPPVAPFGVPSAGVSYSPYVAPPAALPQSLQYPPQQYPYVAGPPSLPANGQVAGYQQYSPPAQPQVPIQPVTAPAPPGPAPPAMGFPMFPYPNFPPATPANPTYAPSFAQPQPQPPRPLPQQLPQPPPLPLPPTVQPPPPPPPSVPPLPAPTSPPILASSTATPKPPQSQPTPPARPASTSDPLSSWPSKPKNPAKVVSIPTTPKTNVQALYDYCNQHGMPTPQWGQELTNGDVRKHKVWVVIGKMKFEIPVPFSSLSQAQERVAGKVVDQFKAQGPVEALKTVVSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG54</accession>
    <name>A0A2G8SG54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG54"/>
    <dbReference type="OrthoDB" id="2749115at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013950189" evidence="2">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="463" mass="49254" checksum="7BAA95C0C110041D" modified="2018-01-31" version="1">MPSFNRILVLAVVALSASVHSAPVADAAPRDLANVNGAIERSVVPAPASDFDDEDVAEDLEARDFDDEDEDEDVEAREIDEEDNDDEEDLEARDFDGEGEGEEGEGEGEDDEHDDEDSALERRAKPKTTKAAKPKTTKVAKPKTTKAKTTKVKTTKAPKPTTAKAAKTTKAKTTKVKTTAKATATKPAKTTKAAKPTKSAKVTKTKASKTTKASATAKASACPIKKPTKPAKKTRMFGRAFDYVAHLFARDNEEFIGWHGTNSDTATFWEEKGQLEKPTKADGVLDFLGLGPKGTTAGTSGADAEIGPGVYVTDDQDIAIAFANNNAKVNPGTTAQLCAIFAKSSSNWRTALRKSFIPENLVGDSSNAAKKKQLEDARLEHIKKAVPGVSASSVVKFSLLNRSTKSGQLVLPATITNQFLAKCFKADGGAAAPGTNKFPAFSYNGQTLRTQWNIAAETAGECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGU1</accession>
    <name>A0A2G8SGU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGU1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="308" mass="31784" checksum="5A4ECF6EF0B77CE9" modified="2018-01-31" version="1">MPPNNPTPSAPSKTPSSSPTPHGIPLIQATSSSDFQGQVIRCYRRPILPGCQFLVLPGPYTTAASTLAAELTGGTTARSSSSFYSFSAVSTPLPPPDAPDPNSRGATPESSSSPQWGFPTSSDFRVSSQSSSGIGTAESTNASTALPTVEHSTAALTSGLLPARATAISAPAVTDLAPSPPGSGVPDLHPASYTPHLAARASNANSHLSDGSVVCLAIGVGVLAACVGVILSWYTARGRRRAARGPHDCCDYSLEGPEDSHRHFGSSASTMTASSVDRGRHGGEMMSEWPMRHMREDMANKVKLSGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGY6</accession>
    <name>A0A2G8SGY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_04460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGY6"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013970376" description="Cerato-platanin" evidence="4">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL33011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17211" checksum="D5CF4DC89D363B4B" modified="2018-01-31" version="1">MLFQAASRALLALLAANFLSTSSRAATLERLSAVVPRNVSVSYDQIYDDGETPANAVSCSTWMTAKDRDYPTFSYIPAFPLIGGADFIDGSNSALCGQCWQLTYYTPTETNIHVVAIDTATRGFTISERAMNALTDGEARKLGRVDAVGYPVAKSHCGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH26</accession>
    <name>A0A2G8SH26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH26"/>
    <dbReference type="STRING" id="1077348.A0A2G8SH26"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="80"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="347" mass="36934" checksum="74335215F788808F" modified="2018-01-31" version="1">MVISYDSARVVTSSLDGTIIVWDTASGTVLQEWLAHEGSVVVPLALSPDNRRVVSAGGSTITAWNIDSGCAAQKTAELNLEGNTGVVNTCIWSPDGALIASVSGDKTVTIWDGCTYQQRDVLPATPSSQNVRALQFSPDGHYLAWISGGKVCCVWTPLALAETQPKTLLPHPDREEVSTTAFAFDHESRRIATAHGDLNSDPDACVVRIWDAATGAPLAVLAGHSEAVSRVSFSSDGRSLLSVSEDMAVRLWDCGAWSGEQTGVFGDSGESLAWHTCFRHDGKYMAAGLEGGRVQLWRMGDGSCVATFGEHDSDVTHVAFSPNGRFLVSGDRDGIVHIRCISTLIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHI4</accession>
    <name>A0A2G8SHI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHI4"/>
    <dbReference type="OrthoDB" id="2803586at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1116" mass="122404" checksum="A074F014C443304C" modified="2018-01-31" version="1">MTTSAEFWKHFEHWELPIGLPHFFSRSAVTSELFDFIVEMRLKSTSAGLAENVKQFHLLEYHRRHYEYLHAYQARTKRMSFEKQKPLVPFSKPLVKKVGKQTGGYDNRSISNDLITAILLKLSNKTRIEESEEHMRTLNAVAISVDTTFRCAYKATLVDKNKAHVQSHLGGFVSVLNEKSQPISWLCHSQSQMETQEMLAGIANQLEILELPPLEIMTADNCCQVRNSAQKVFPDIDVVQDVWHFLMQYVACIQDGTKNPYQGQVANDIVDAILKAKAANGVPAIYRPQAEQEQRLVEVYNKWKEHGGMWTAVAEKVHAKQLTHVQKDCLTRPRDDIVTDSSRIEGSHKGWNSIMCAFASGLEVMNALGHDHILHHNVRIDMQDDSLDKSMFMYHTYGSHHIRLMNACAKLWNTLVEAEKKKGLKPANLRALPVFCPADSREKFALVKMSAETATQYSLTTIKQEPGDESLVLSSQDVLDPDRILKEIGIDPTLLNTPLESDTPEQRVDASLTCDSKGKGVKRTREEDSEDEIVELSQAEWRVPAGWFPAAQSTMPTLQAALATAGTSTLFPASNVSVSNAVATVLTMTSTSSANIPTYSALPAISAVAPFATSSTLSLTPSATAPSAASSALPLIPSAAIMPAASSVLAAAPSTISNASASGALTTTMSAISSAAPSAAPNASTSSAPGALTTMTSGTSNISASTPPAPPMIMLSPSLNGPPPKKKSCLSVAGMPTPSKSMQNNSNQPKQYNQLQNNPGTLNAMFSQASQATTGNASTGVSPSALTPTNELCLPRPAIVGLTRSQRLFSVITQVDPRSLTFGSGASSREFFLFMSLWATHRWATFQMSPYDWVCAASTYNTAIKDLNHEHRSSLPFKTPRALLDKLSEVEGKIFVCIRDSNYCSRSGGTAFWEHHCKAVYLGAKIQRMIDDTTFKMGKNHVCGRCKRIMYPEEKNHKGANHSRKICSDGVRQTAEKVHLTINGISRDFLEQPPPFPQPNDIFTNGDVFHPARFMEFLTRFYDRVVVNQSTPGALAMTDHTFAALLYDRTVVVPGLDGRPSKYIFKLFHSFKLAPGEAVVLDEHDGETYLRMDCLSEPPLEVLQDNGQDNGLSGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHN4</accession>
    <name>A0A2G8SHN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHN4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHN4"/>
    <dbReference type="OrthoDB" id="2800059at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="42"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="376" mass="40632" checksum="62F40BAAEBBE5D66" modified="2018-01-31" version="1">MSSESEPSRKRARVEGEESGSDANHLPASGLKHDDEVWLSDGNVVVVAADNVAFRVHKSTLERKSEIFRDIFSLPDADASTTDAIEGCPVVHISDSSNDIRPLFLVLCCGKNYYYDGDALLAVPFAVLASLIRMAHKYAIQDILDHALSRLKRYYPSDLAAWHDSASRARYVTTRPEHAPEVVALARLTNTPSLLPSALLLCTELLTAPAPACRQPGAGRASEFKLAVLAALAVPDQALPGLIAARGYLVDICAQRALRLLALVPCAGCTHPGMCRAMQDAPLVALRSGVVSKVPLFYAQDPLRPMVGAVWDGLDRAMFCAGCRKALVDADEAETRWVWSSLPGIFGVRIGRDGGGWPSAPGEVRREIVAIEPCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHY0</accession>
    <name>A0A2G8SHY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHY0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHY0"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="545" mass="62399" checksum="EECA2DF771C995BF" modified="2018-01-31" version="1">MVGRDIILKVIQKDSPQHHIFQTLLQHQSLFTDPRTFPGVLPPIDIIETPHKYSIVTMPLWGTYPCLTEMEDVRQVLTFIRCLLEGLSFLHANRIAHRDICDSNMVVSCYRPDRDQKRFGGDLRELRRGTDIRYAFMDYDQSIQLPLDVSVKHCRRPSREAWMGCDMYKPLDVSLGESQYNPFAFDVAMLGNMFRAYLSEAIPTLPALAALFDGMTTHVVSRRFSADEALDFFKSNIQLLPQEVLVAPVTLEFDYEMMYHPERYWSKLAPPVQARWNQFRAPPLPRWWHFLNWLMQLPACTRVVEWYCDFRDIPAPAGMYPLPFNLILKNVPRVREQEGLAMNLARAMGVPAPRFISFAEPPPDYYFSDGIEPDDQVDFDVIKDDLVHILTLMRSFSSPWGSAICGVDGGPVAGPLVPLTPLQASPDEAAFYQLMRHLGSFELKDKNETAGAEKFFALPPHAIVFTHGDLNRHNIMVGPDGHITGIIDWEAAAWLPDYWEVSVTAILPQRHWGRFMNETVTSGIYAEEVVGHREMFSFIGDSLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI76</accession>
    <name>A0A2G8SI76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI76"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="109" mass="11850" checksum="FD69E565C78C6CFE" modified="2018-01-31" version="1">MAVAFAAAASGREKRSEKTSDRRDKMLLWTRKATVFQVAAMTTMFPSDSAESHTSSSRLSLKNWRPVFFVYTRTLARSGAIGSGGLGFAVGWSSVSCRNKRNASSHAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJF0</accession>
    <name>A0A2G8SJF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJF0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJF0"/>
    <dbReference type="OrthoDB" id="2750010at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF38">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="299"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="675"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="730"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="854"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="730"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="911" mass="99455" checksum="E20F04C193384EE1" modified="2018-01-31" version="1">MCTAHNKVCKYDPAAKMKRPSKKYVEALETRISKVEDLLMKLQGDSMLPGNDAENVESSPSPPAPQPPLRPSVYKHPHANWSSSKVIYPRGVHPTTDSSEESVDPSDNEEGFGVTDVNFKGYTGKSSNFDLVRTVIDMKSEHKGAPLDVDYDKPFIQIQKRFQPDLLAVGAMVSSIVPPLKEHDFPPPDVIAQLIGLYFEHFNTYLPVLHRPTFEREVQSGLHGRDRGFGTIVLLVCAIGSAWAFGSLNAEPHQAHGWQWFNRVSLTDYSLLARPRLYDVQVCALMAAYVNTTNSPQGTLPVISLGIRMAQDVGAHRKKMYSATPTVEQELWKRAFWALVAMDRLASFGMGRQCITHDEDFDLDPMIECDDEYWTHPDPAQAFKQPPGKPSIVAFANTFIRLLKIQAFASRTIFTINKSKLLLGYVGPEWKQSIVADVDSSLNKWLDAIPSHLRWDPNRTDDVFFNQSAILYANYYVLQIFVHRPFLPSPRRPAASANLSLPSMTICVNASRSCLRVLEVQHRRSMNSCSGFTLYALTPLQMPLFEVGMMLLVYLWAGARDIETTLKDVHITLAILKDLSAAGNLVARKLEIVLRAMCPPSSRPPSEEPFSTGPSVPSPPKFAQEGPKTIDELIAAAMQQLSLSGFRIADDCDIRADPTNGEILSLFTAPKRDLASPSPFVQTAPSAPAGATDGAEASPSAGFNRPFAGREGWADQLNALGRDFVPTRFPSTSASAAPSAPPDAATTLSAPAPTEPPSFELGAVPPLGPTYAHMGGEPELVDFTFGNALLANNLDLSFFGPLSSMFDNGQSQNLGMNYGMNAPPPSSVFGPPQYASVSAPLRTATTALGGAEEWSQAPANPAPMEVQSEGHGGGNEDQGPWQWQGLSAPQGELWAQWEAYLHNQGGTQPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKA5</accession>
    <name>A0A2G8SKA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKA5"/>
    <dbReference type="OrthoDB" id="2748014at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="170"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="557" mass="63100" checksum="77EA92AB4E03D18B" modified="2018-01-31" version="1">MAILMFRFEIVHVPGERHDPDGLSRRPRQPGDPDEEDDGFDDWIDRVHGLLHFVNEPVGAEDVCDLAVALPLTEEPLAVFALGNPIQAAPGVGETPPYDAFPRSECAKRLDGLLPVIRNFLDDPKRPSGQTDKQWKGFYKFASQFLLDARGVLWKRDAEGRRKLVIDVSDRRPSILVELHDRLRHRGTYATASFACERFWWPDIKADVHWFVKTCHACQLRQTAHVLIPPTVPIPLSPMMHIHADSMVMPGRYKYFVHASRWGALSEVVTDNGMPWIKACDYLAWKYHIHHIRISGYNSRANGIVERPHFSVRDALVKAAGGESDRWHAYVHTVLWSERATRRRRFGCSPYFAITGSHPVLPLDFTEATYLVPPPDSLMDTAELIVLRAIALQKRAEDVARLRSRMYETRVREAREFEVKHRAMIKDFNHTAGTLVLLRNTAIEKSLNRKTRQRYLGPYVVLTRNRGGAYVLAELDGTVFDRPVAAFRVQPYFARKDLIALANDALDTNEGRLKEMEASVDAGEGADDADDAEDSEVAEIPEDPQSAVDDIASDDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKD5</accession>
    <name>A0A2G8SKD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKD5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKD5"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="594"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="2">
        <location>
            <begin position="872"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1115" mass="128142" checksum="A4928546ED8C648F" modified="2018-01-31" version="1">MAQQSTHLKKLQAKIFRSQNGDGLNGDDKPPKPADSPTQPGGLTINIPNPVLTSSESVQNGPSPPKMPQEQTTPKQAEVKADTRPFRQRIAEQLGPEYHGAERLRLDQDCEKERHWKRWGPYLSDRQWATVREDYSANGDAWSHFPHEHARSRVYRWGEDGIAGISDNHQRLCFSLALWNGQDRILKERLFGVTGHQGNHGEDVKELYYYLDSTPTHSYMKFLYKYPQKAYPYEELVRENINRDRDVSEFEILDTDAFDDDRYWDVFVEYAKDEQDPDSVYVRITSYNRGPEPATLHIVPQFWFPNTWSWSNSPPPKPSMWASGDGIVSAQHPTLGKYYLYCLPSPPPVNNQGELLVGDKGEPEAVEAELLFTENNTNYHRLYGGQNETPYVKDAFHDHIVPSHRPQDDDGHPGFFHTKIRSSYARQRHGSADENTRSEEEQGPRTPFPAGPSYVNPAKRGTKSAAHYIFHDVPPRGGCAVVRLKLTPRTPREDPSIEDEGIFDDTVEERRGEADEFYSGLVMGPISDDLKQIMRQALGGMLWTKQYYQFIQQDWLHGDPAQPPPPPERKHVRNKDWKHMYIADILSMPDKWEYPFFAAWDTAFHCIPLAVVDPTFAKKQLDLLTREWYMKPDGQIPAYEWNFGDVNPPVHAWATFRVFKIERKLYGREDVQFLERVFQKLLLNFTWWVNRKDQGGNNVFEGGFLGLDNIGVFNRSEPLPTGGSLRQADGTAWMAFYCLNMLNIALELAKHNPTYEDIASKFFEHFIFIADAMTFRGRGEDELSLWNEEDGMYYDAIQFDNGCSMQLPVRSLVGLIPLYATLVLEPSVVNRFPGFKKRMEWFIDNRPEMSERNMANMKARGRGERRLLALASKERLVKILEKMLDEDEFFSEHGIRSLSKKHKDQPWGMDVHGERYEVNYWPGDSKSGMFGGNSNWRGPIWLAVNFLLIESLQRFHQFYGEDVQVECPTGSGDYMNLVQVAEEIQHRIIHIFGRDVEGKRAANGGNPKLDHDPHFRDYVWFYEYFHADDGRGLGASHQTGWSGLVAYHILQSGATCRLPRTPKTPRSLAHHYFDETIPQSEYGQSEYGDSDAQSLHSAYSTADLNTLGDISPDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKF5</accession>
    <name>A0A2G8SKF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03965</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKF5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKF5"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="170" mass="19537" checksum="400347D80CC9DDFB" modified="2018-01-31" version="1">MSNVLRPYLAAVRSTLTAALTLEDFSSQVVERHNKPEVEAAASKEVLLNPLTISRNENERVLIEPSVNSVRISIKIKQADEIERILCHKFTRFMMQRAESFIVLRRKPVKGYDISFLITNNHTDTMLKHKIVDFIIQFMEEVDKEISEMKLSLNARARVVAESYLSAFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL38</accession>
    <name>A0A2G8SL38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL38"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="187" mass="20347" checksum="80333494D60F6BE9" modified="2018-01-31" version="1">MSLSVNKPLTETGSASSQGPSQQTPRTPNVTQSLPLALAGHVHVLINHYWQDSSFRPNSPFRRHASKQPGTIMTFFAAWEGPVRWWHKGAPQVRNSDQLGSLLVLTVVVAQGPGSYLDAEYGACITVSDRSDQDIDCIVKKPGAVAGHLERDSQVRFTRSGCLGSGKSVLWTSDCSNSWVQMGEENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLD1</accession>
    <name>A0A2G8SLD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLD1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLD1"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013621011" evidence="1">
        <location>
            <begin position="19"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="371" mass="36197" checksum="539CCF4443D955F5" modified="2018-01-31" version="1">MKFSASLLILSLAAAASASSLHVPRRGGQRGRFGAGGNHKGFTASSSVAASSAAASVAKVSSVAASQSAAASATAVGTAAAASGSAAATGVSSAAVASSSAAATGATSVASSAAATSTAAAGDNGAAGNAASGADAQSSLTLLNSVIATGFENDGQAVPEAGQVASLTSSNNFINFCATEPGKPLTNGLQIVTGSCNPAPMGVIAAFTNMPSSKFVFPANGATVPANKDFTIQMAVKNLLTGNFVNAGENYFSAPQQIDAASGNIKGHSHVVIEALPSLGSTAPTDPTRFAFFKGLNAPANAAGILTADVPNGLPAGSYRIASINTAANHQPALVAVAQHGALDDMAYPIITPDAHHHPHHPRFASSFTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLK0</accession>
    <name>A0A2G8SLK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLK0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="14305" checksum="4547BB803D31C0FC" modified="2018-01-31" version="1">MPTLLTDRSDLVLGIRIMLGRGAAGAGAGAGGALGVVRYTIPVPVLGLSLDMLDGGELSPAGLGLDGDWDGKVTPATGGALEAVEVERAVVACGWRRPWEGIWRRLGALAGPALAQRGVQVVGVDADIDVALEGVRKLPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLT1</accession>
    <name>A0A2G8SLT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLT1"/>
    <dbReference type="OrthoDB" id="10671104at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013775635" description="Transporter" evidence="3">
        <location>
            <begin position="20"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="26044" checksum="9727C0C1C11906EC" modified="2018-01-31" version="1">MQFFKPILTLVFILAHAHAMAVRTVAPEDGVAHAPPVGPATEAAAADADTTVTATTTVRVTVTLSSAVPPHSATPTTISAPRPASSSHAVDPTTSAPAPHATSVETTAHASTTARGSPPVSVRPAPSPLDSSSSVTGAGATSQVVPPNEPVSSAPASAPAPVSGAPGSVTVRPSGSGSISSGLALSSLHASTTLTVSSLNASSSSSASASAVLFTPNPSVDPTVGTLPSGSTFHDNGVAPPVRVGGAGVAVAVGVVVAVAVAMGGGMVGWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLW7</accession>
    <name>A0A2G8SLW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02563</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLW7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLW7"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="283" mass="30101" checksum="ED04020596EC2701" modified="2018-01-31" version="1">MSTQTSTAKRVAIITGAAEGIGRGIALRLAKDGFDLGLFDLPRAKDRLEELADTVKKEHGTRVVTVYGDVSKEEDVKGLVETVVQELGGLYAMIANAGVAIVRVLHESLAHPALELSTPVAIGFPAPTEELDRLININVKGVFFSYKYAAIQLIKQGTGGRIVGAASIASKKGFPNHALYCATKFAVRGLTQCAAQDYGKYGITVNAYAPGSIDTPLLDELDEYHAVTNGQPRGVFKDSTVRCALGRIGQPEDVAKLVSFLVSDDASFITGQSYLVDGGAHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMC5</accession>
    <name>A0A2G8SMC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMC5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMC5"/>
    <dbReference type="OrthoDB" id="3188866at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="42717" checksum="98A5160789F1C6B7" modified="2018-01-31" version="1">MALPPDACSLIAKYAAGSRSTLVALSTVSKQFQTAAERAIYNTLDVRGYDRTITVCDVLRHTPRVAMLVVALSVYGEAEANEEEDEEDEDEAESEFEPESDYWQVLHQALVRTTRLRFLNLYFTSGDQPDKAWILDGCTFQLKTFHSDLIWDDHLATFLATQARLCNLFLADYREPAADEMAPPVVPASAGFLPKLAVLECTFAEAAVSLVPGRPVVRVKTCFTHSKLEEKRAELRAIVAALRRSRRRLRALDIADSSYTPAFTLELLAGLTADGALCADLRYVGTLVFPVDGRQRLEFYGMLMRLRHLRCLEVDVSEWDPPPTHFAALRALTFELLLYCPSVSMVIFVYEFERHLVRVVDHAVVYDEDGATENLWREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNR3</accession>
    <name>A0A2G8SNR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNR3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNR3"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="511" mass="58418" checksum="8E452135D1658407" modified="2018-01-31" version="1">MLDLPDPSSSSSGNISKYFDAVYEQIAFNVTALLYQEQITSGYVDKECDVLSLLREDFANQVLKVSTIAPAMKTLYESIKENNIARITLHDLPLELQLPPFLDSLLQADEDGYCEEDIVDEDSEPNLMPGALLRLNDEDDGQGYQLYMQLRAAQLHPEERELAEQLLKFLELASVNLSLADMASLLDWHLEAQVYPVVRWLVMHRRAKVVDVVHSSLKTVFSVPQKFPSKLFLSFLIPFIALRGLGDTGDTPRLATLSEEFSKWFAVSGVPPLPKLLAMISTATHKTTANHFYVTVVQSKDFIPLYLDVVLWMLKRDLLIRLHLRIRIIATEELKEHVRQAWEQHIAHKRSRSRTHSNSRRCGSEGRRKGRRGGGNSDEKAASDSSPVEYWVSLSPKTARKRARQPADGHDKQEEEERDKVEDRDEGDDEDDDKDEGHHDREKRNEEDVDEEFLSSSMDEAKWAEYYKDGVENDNIPSMIGDSARATPLERRWLAGMSEGKEPHIVRRFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNX3</accession>
    <name>A0A2G8SNX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin GTPase-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNX3"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="62"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="650" mass="72255" checksum="05A370A5F7BD1EF6" modified="2018-01-31" version="1">MFKSILPSRRIPSSSDFQMLTSPIDSAESDANGKENYFAIPYDTTTTNNAKPKTEKRKKMKGKALPEQETPQDFDRLLDELQIPSTLRPKLATMDPTVKAAFLKSSHVLAQMKPAPAPLTPRTLRRVHSSESMLSSPRPQKPSLEEYDLTETPLIPMALGTSHSRGKSLDVRRQAMEPKPAPIAPLKVSKDKKKSSTTTPEKYVNILLSQSSTNMDIEVIKKLRLLLRNESASWTEAFIQHGGYDAILTRLNEILDVEWREEQHDDQILHELLRCVKALSTSAVGCVALRDHCPAPFDKLITLLYSDKKPGDVPIRQLIVELLLGLFDLYPPSSLPSTGSPAAALSHSRSRSVPWELSATAMSSTSNLVVLPRPHATLFSLIKTLLLTPAPLPSEAPGTPLEPHAFIEDLHRPRVYKTYLQELSDVCRDYFWVFCHPSNTVWDLHETDEAKVEKPRAPGGMTGGVEFEAMCYMTMHFKFLNAIASHVRALNLPKDHEHSAYRFHQDMFQSGIERIISVARKASTTYYPTLHLEIARYVAAAGLSGIEVPWSLSRMIGQPPTAMRKHTFVAAPTPVPVGLPPRTPPSRSTPTTPTKRSMPPPGFAGYDSRPQPGQSVYPSGYAAAQSRTSIDIERGRTPAPQSRKVTPMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP00</accession>
    <name>A0A2G8SP00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP00"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20181" checksum="E61A676544EC9705" modified="2018-01-31" version="1">MLAAEFVVRLHPKGLQRLVITNSPAAVALRAKSTNDLLKKFPQPVQDAIAEGEVKDGQAWRDAMMAFYARHGCRLQPFPAEVLDTFAYSFGANGDRTVFRAGLTRDWSIVDRVNQVDVPTLVINGQYDFVQDYVMETYVNGIPGAKWVKFEESSHMPFWEEREKYMEVVRGFLDECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPB7</accession>
    <name>A0A2G8SPB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPB7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPB7"/>
    <dbReference type="OrthoDB" id="2757285at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1188" mass="130213" checksum="043335BF48990635" modified="2018-01-31" version="1">MLCDLPDDVLFLILYELDVHSLLRCKQVCCTLKHVIEGSQRLTYTIELGINGMIDGPSTAGQSVGERLQALRQYNAQVYAGPSTSQDVEEYEGSGWSEVQKAAARHGCCPTAYVLDHGRTLVVNEPRFAQGSLEVRRRIVSLEPGMVLVAVDISQDLLVLYKDRPDNLWNKGVHLRSLGAQVGTAHPEATLAVLKNVPFSVPTIHLGDHDNARTSIKDGQIYGPFVAWKVPYDDRETTYALEVWDWKKGILVWHGRFPSLSISTYTLIDMAYLAVELWGRKVAVYRFSSPEIDSTYPSFDITSQPSVAAIDIKDTTPLFSLELFPHARDCCIVEPSPCTISPLPPPAALFWPDPALRTIAVQFHVSASSKLRNLLGDSLNSTFVVLIPQSTFREHLERASARTEGDGPLRVPWRDWGERGSVVLRSGTFPEQPHLAGLYTNSRVVPFGSRVSVFLLDSADELETIGKDKDYSSLPKWRFQHIWGSYDLANVMLHPEKSVPVFGARNLVCIDLPPVRQHMQVLAAILFAAASGAAAVAPYQQYILAPSSRTVRPAAVYLQTGSVSSEHALLDDQVFSGQPSLTLDTFNSSVTYDFGKNVGGWINFNTTSIDGSVGFTFTESSLWVSSEACDSTSNGGLDEPLVFNLTGLGHYVAPNDKERGAFRYLTIVNLGSDQVSIDDLWVHFTAMPHWADDSLQNYTGWFHSNDEKLNRVWYAGAYTNQLITIDPTRGDAIVHFGFGNISNTTLDWWLNTTITNGTSTLTDGAKRDRLVWSGDMAIAVPGIAITTFDLISIRNALDSLFVLQNANGQLPYAGYPFNILGVVSFTYHLYALIGVRNFYHWSGDQSYFDEKWLQWKAGMEWAVARIDSTGLANITDPADWLRFGMGGHNIEANSILFYTLNLGATLAQNQDDSATADRWSQLAASLQSAAIPLLWQPDVGLFKDNETTTLAPQDGNAWAVKSGLVTNASQVAQISEALQARWGPYGAPAPEAADAISPFISGFELETHFMANRTVAALTLIRNMWADFMLDDPRMTNSTFIEGYSTTGELHYAPYPNNALISHAHGWSTGPMSALTTYVGGIQLLSEAGATWAIVPQVGDLTHADVGFSTSLGGFSSKWSTNTTVFHLEISTPEGSTGTVGLLLPGNHTSAILTGKDRDGDIVHGDKLGRYWVGGLAGGDYEFTVVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPI7</accession>
    <name>A0A2G8SPI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPI7"/>
    <dbReference type="OrthoDB" id="3271227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="659" mass="70743" checksum="999B33FB4C4681E8" modified="2018-01-31" version="1">MLLSSTPSHTATTILTTQRVSDSGVEILDVERMDIAERAKLRSRGRSQAKGKQITYDDVIELSSSDDELSLPKSKPKPKPKPKAKKPAAPKESGSDKGKLKGKSRVPSKPSPSKRAKTTHIPDGPESDVDTIPVATSDFPIPAQQPPLPPLPPHIRHLSSQLPPSDPPPSTSGSSAPRTSQDRQLNANADRFRDESPLSSPPPPMPRKRKRPSPPNYIPGLDDEDNSYMGADDDSILAGPAPGGMVPVVEITRVPKKSRSKGSDPPLPPPSPGVVPETQLADPPAEHQEKPAPQKKKRKRVVEDGEEWDAGLDEELLAQAVKSKSKKRSRADEEDEEEYGASSSKAKAKAKKDKEKPAKKAAKEKVPPKEKGTKGKANAKGKASSSSSKGVVEGSDTEEMSISIDGDKVRDAMPPPPAPEPASKHKEKDRPSSSKGTSDDPGVPVDVSAPKRGKGKQRALILSDDEDDGAHTADVSTNASAADASLDIDWPPPARAKKGGRKSAGGEQGSKLSCRCHINSSAGRSRDAAAPPHELRTVEPRIHDLVQEDEVDTHVRAHPAGLLAPRLPFSRVVAPDVLAACQGVEERPPAHRTVASQPPDSPASPSAAPPPKKSKKMLELEEKWEMELEDSIDGWYAMSEEERATLRRAKRDHELGFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ16</accession>
    <name>A0A2G8SQ16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ16"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ16"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="14986" checksum="D5002A233132CB53" modified="2018-01-31" version="1">MGAGVEDFQMEIPEFQGPEEQRGRSKSLAPSELTGLSEPPLDPFLEEGDENHADVTRSVALFDGYRTVASQSQTQSQGPSEGSDDGKGYSKNTVKARAVIRRELQPNTEEPEEDRYTSFNNMAQKRCGYVTGPGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ80</accession>
    <name>A0A2G8SQ80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ80"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="304" mass="33876" checksum="1571C78071720BAF" modified="2018-01-31" version="1">MLEIRKSSKGSGKVSSQERKEDTPIVTTTTMYDERSPGRPELTQLGCDKCCRIFKSWQHLESHRAAHKTGQVQYWCIPQCGAGHTSAMELQKHQAHCQEILAVRYFDPTFVPPPIAPSPRPTRSGLHPPNHQTGAQTETVNQGLGTVTVREQAQGSPAKRTVRYWPKCDHCPRRFKTKTALWEHDAAHKAGTLICCPTPGCGSGYTTPREVKTTTGCGVPQSAAEPALDGRHGIPGGDAGVVKAIWTSEGRTRILQDWQEQALEGSYRRCAYPQKDELYRLSDEICIAIDIVRRWFSTRRMQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR01</accession>
    <name>A0A2G8SR01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR01"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR01"/>
    <dbReference type="OrthoDB" id="10027144at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd22448">
        <property type="entry name" value="KH-I_ScSCP160_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22450">
        <property type="entry name" value="KH-I_ScSCP160_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="163"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="568"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="648"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="734"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="818"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="892"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="973"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1257" mass="135361" checksum="F5F953433334E761" modified="2018-01-31" version="1">MALSAADLQRRHELEGAPDPFPSLVEDSPVKARAAASNGHGNGNVDTESHEAFPSLAPAAQAGNKPVASAWSANAGPRIKPAASKQPVVSDTFVLSSIDLSTAGKDGKPMSLGEVIKQVQAQYKVRLDASTNQKSRQTTFFLKADSKKELDKAKRSLLALLSPVVSLVLNAPASTIPTIIGPKGVTLKQVRDQTNVKIDIPRRDTLTPANGNASVDPSRTATPLPGTPVNGDEEEEPTVPITISGPQPLVYEAQALLNDIIATKRSRTTQRVRDIPEHVLPFILPRRKTFEEAANGGEINLTLNAAAREITVSGDREAVTRVVESIKSAVDYFTAETISLKLSLPKRQHRLLTGKNAEEIMAKARCAVILPKPEEASEEIIIWAKSSDVGLGVQTVMEKANSAYIHEFPLPGPISVSRQFLTYMVRVNYAKTLSAANPGVQVFTPPLSTIDRATTINVDIVGDKPSVDSAVSQLSALIGKLYGATKDVQIDWLLHRIINSHKNAKKIKAFHEVHNVLVFFPPESAEQSTVLLVYDPTSPNASPSPVEKSKSVDDVEKELLKLARDAADVKTEAIEVEKKWHEAVIGRNGTTLNAIIGEDKTLSIKLGAEAGKDSEDYILVRGISADVDRAVTEIRKIVEDAKNEAIVSSYSTEFEIEREFVGRIVGAGGAGVNKLRDTLGVKIDFSDEGEEKEKEGGKKKKAAHLKSKVKIVGRKENVEEAKRRIQAQAERLADETSEVLKIQHQYHSSLIGQSGKYVIRLEEKYGVKITFPRESSADGEGKTREALKPDEVLVKGGKKGVAQAKQELLDAVEFEKESNNVVKFTVPVRSVARILGKAGSTINEIKDTSNVQIDVDKSPDDKDNATITIRGTKKAIADAKAAILAISEQVAEETTATVDVPSKFHRTIIGAGGQGLKDLIARCGGPTDPKAQAGLIRFPRQGEPGDEVRLRGEPKLVAKLRAELEKVTADLKDRVVLGVDVPVAQHRALIGRGGQHLNDLQSRTGAQIQFPGSRSYAQVSEPENSADLVGVDPGNLVKVSGPRTACEKAIAELKAQIKPPAPEGVTGTVTVPLKYHYAVSQQGNLFRQLRSSGVHVEQSVLPSKPAVPPQPTSQGVGATARIDDPDAEDVTTNEEWQVVSNYQDAEEGESEWTLKARDQAGLDRALKLIGEGLAHAEKMTHVGFLTLPDRSMFPRIVGSKGSNVARLRNESGADITVSHEDSTIVIVGSETAIIAAKDAILKMTTSSGPRRGGRRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRI8</accession>
    <name>A0A2G8SRI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chromosome transmission fidelity protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRI8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRI8"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17706" checksum="5912E625E5CFF016" modified="2018-01-31" version="1">MLIPINIDLPGPSTPRRPHLPSQLVQFGTDELVLIELQGVLEVEGNRDGQLVGQLEVDSATKKPTLMIGYHKLEGKLVNLNKPLAVLHRHDSQPKNEDNEDAAMEVDGSEDRVGGASEAKSWDMIAIVKRKMVFSKRPMPVVSQPDKKNSGTAPLSRIGSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRI9</accession>
    <name>A0A2G8SRI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRI9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="69" mass="7596" checksum="63A8FD6B85A8435B" modified="2018-01-31" version="1">MTISTTSSDEFVYSLFKPDCRQIPQGGLSGLTDITTIHASRSRRVVWRAMHSHAEPAKDSLTLVIHPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRQ5</accession>
    <name>A0A2G8SRQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRQ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRQ5"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="36305" checksum="919A62D8BBB2F7DF" modified="2018-01-31" version="1">MKDPSSSRVLDQLPLPVDSKATRRSTGARFLPARRAMVVLFGLIALTYIYYTHAALPPPGSLRDVDGAREIPSLGVSRTIQQSWAMYSPYYAAEPYVSPPRGCSVDQVHILQRHGARYPTSGAATRIRTAIGKLQSVDHYTDPLFTFLKNYTYDLGQDSLIPFGAVQSFQSGEQAFKRYTSLVTTDNQPFVRASSPPRVVDSANNWTAGFAAASHHRYNPTLSVILSEAGNDTLDDGMCAAAGSSDPQTNLWLSTFAPPLTARLNAAAPGANLTDADTYSLLSMCAFDTVAHERPSPFCALYKELNGGPGFAYTGDLTSTTARGTGSRWGACRASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS16</accession>
    <name>A0A2G8SS16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS16"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS16"/>
    <dbReference type="OrthoDB" id="2756770at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="978" mass="111595" checksum="136F784E3BC4BDF7" modified="2018-01-31" version="1">MPSQSHPIDYRRASKPFELIHVDLKSFPVPSYHKYQHEILLYDDYSSYAWSISLRTKDNALQSTRQWFSYVETQYGAKVIKWKSDSGGELKAHAFTNMLKDKGIEIIPSAPHIHQQNGRAERIIRTLMDKSEAMRHDACIPQSWWEFSCEHAAHLHNRTPTRRLEWRTPYELLNGTKPDISHLRVFGCGAYVFLPPEVRKNKLSPKSELMIYLGVGAGNHNHKFMRLPNNVIFTAAQALFDESLFPKCSHEKKRQGQQSAPEPVEPVDQATTPSLLPDDGDEPRRPPTKPSTKGKGKLRLYPLYLLNLVHSTERTYQKCNTLCRRNLLRLTGQARKNRDGLRESGKYQFTKAMSMVKHDTLQTFLRTLRNGDRGSKWLRSAEHDPPVPIPPSMRTHREPTPVISSSSSDDEEEEDMGSDPIPAFVLPQPESPAPSPDRSDPDDDDDDDDDEEEEDSSDDEDESKEESSGGASLIQFLIAKAIPPDEGEKVPPANVHEWTYCDIASLPNAERKEWFTACREELEALRRREVYNLVNHPKGHKVVKNRWVFDVKTDGPLEDWHISGLDVRSAYLYGKLDEEIYLEQPEGFHISGSEHKVFRLKRALYGLKQAGLAWWRTLSESMKLMGYKRLTNDAGLYIYKRHSDGELVVVIVYVDDALFCGRDKKLVALLKARFMKKWECRDLGDAKEFLRMCITCIGRKIFLDQRAYLEKVLDRCGMTNARPALTPLPAGYIPAPNTGQATPELRSRYQKVIGSLLYLMLGMRPDLAFAVTKLAQYAANPTEDHLSKALHICRYLVGTKNYALVYNGDSQLGLIAGTDSDWASDPYTRCSQTGFMLKLANCAFSWVSRAQKTIALSSTEAEYMAMSDCSRQVVWVHNLLAELGYHIGRVPLSGDNQGSIHIGQNPVTESRSKHIDIRYLRLNPYRYHYVREVYDRGITDIFYVEGTNNPADIFTKNLGTVKFHHFRPYLGLHFPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSU6</accession>
    <name>A0A2G8SSU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSU6"/>
    <dbReference type="OrthoDB" id="2804680at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="404" mass="43221" checksum="B6231797D43838D0" modified="2018-01-31" version="1">MSFQGMYPCCCRYIIILTITDLSYLQDQSPLVKPTCPPSIDSDNPSWATLSTANTSSDEDALDLESQATTPEPVDEKALSSYTTTLHSSFPYQQPTSNYSPSTTSKNCPSTGLKRGPSPASDTLSAHALPAKKAKKTSTHPLHQSHNTLLDHQPLSTHQSGFGILPRGPITTLTTPLAHLTTSQKQQLTPFSSHEIHTASLPSALTHQVLQPRKPLPPITNSSGVEDWALVDDALGTQVASAHNLRVHRSTQFLAPWEPESSIDAGRPGGAHFPLTQFADLAKGSKGKERARSGWTAPRWSNVGDFKARLDAMYGPGDINRGLGRGPKNIPAGNAVSGTAPDQPTLVGLPEPGAAQGSALTEDEDEPDMSLGGMRRGRLENLSPQRDTRASWRHGAAGKGPEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSW6</accession>
    <name>A0A2G8SSW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSW6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSW6"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="328" mass="35303" checksum="B2DD1BE35D63D269" modified="2018-01-31" version="1">MITATTKLGGTATNVVVAKVAGATPIPDEQAFESIKSSIDALPEGVKMMLNSAEFYGHGGTTGNLELLARFFEECPDYADKPFLSVKGGAIGFGKISGRADDLRNSVDKSIVALRGTKKIEVPIENIVGYLVEFFREGKFDHIGLSECRAEGLHDLGVYPISVVEIQISPISYEEETKKVLAASAELNISVAAYSCPHFGFYPLGHGLIAGKIKGMGDLPAGSWMRDLTRLKDENLPANLRLIDAILAMAAKKNCTPGQLSIAWVGALGEKVNPLPGSTRKERTLENLHGGEAVLSKEDLDEFAQLLDANPVKGDQDFWDAVDLKLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST72</accession>
    <name>A0A2G8ST72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST72"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST72"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="70"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="19870" checksum="518D280CBB2C57FA" modified="2018-01-31" version="1">MVWRNINTVIEGKLFLGTIDAAISPRTLADRRITHIVSIGSEPIPADNPASGIRHLRIRVEDVDYADLLIHLPSACRFIHDAINSGGVVLVHCVQGLSRSATVVAAYLMYSRRVGASEAMEIVRRAREQVWIIPGFQEQLVLFGLCQYNPTPNDGIYFKWRQKIDRYLQSQGQSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STZ2</accession>
    <name>A0A2G8STZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STZ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8STZ2"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF646">
        <property type="entry name" value="HAEMOLYSIN SECRETION ATP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="342"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="609" mass="67068" checksum="0289ABB72F7C3DF0" modified="2018-01-31" version="1">MFTLDLVRGIFPAFRGYSQALMIDELQRLISSGDFTLANILREAVMELARMSCEAALDIIATSNENIVHNSARFLVERKQMEQKLRLDVPTLSDPLVRDLLQESDAFVRSFNGFSAFGVFSPFDAMRLLTLISEVLTHLWVLSSLTFGGTPLSIILLSITASALPSILPWLTCGQNTWDHSDGQLEARLTAKQEAMRGLAYSDSYRPEILLFDLGPWILKSWSRARKSLLGLERKQSGGDTSLSSYLLSRIYLSGMFSTFQNIPLLLVLHSTSTSVGTFTLYRNTLQSLFLTAETLFRTLRMAFQGVFLMGAFCAASALKPRLQPEAHSTTSYDPSGAGMAIDVRNLSFRYPESKILALSNINLSVKAGETLAIVGYNGSGKTTLVNVLLRIYDFEGGTLRVNGVDIRRLDPHDFHAHVSAVFQGFSKFSASVKSNVGIGFVPEMNSADAIDAALELAGAADLVRSLPDGVRTRLDGDELGRSCDVFCGDSAGSQKLHGLSGGEWQRIAISRALMRARRPEVELLVFDEPTSSLDAHAQKHVFDTIEQISRGPNGDRTKTVIYITHRLATARRADKIAMMDNGTIVEFGTHEQLLTRNGRYASLYHASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU96</accession>
    <name>A0A2G8SU96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_01042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU96"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU96"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="5">
        <location>
            <begin position="48"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="168"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="486"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL37349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="570" mass="63572" checksum="179EE6444B75C0E6" modified="2018-01-31" version="1">MMPRPPSPAPAFPGPYPTHNPSMSANYERKQKQRSIMGITAGAEDVKYQAKYRELKKKVKEIESDNDRLYFKLLLAKKNIRRMNLERAILYERLAAVPPTPGRHIQELPPEQDPIFHAQPPVPPEHARVIDPNDRELSEYIRNHPTARIIQGPDGRVVAIEDTPANVDARGIPVPSGPPPPHGIPLVHGFRHDSGPGHDPSRPLPPPPPMIPLLQHSQDPTPELSVTNDHHVNQYTYPQSRPPPPQNSHSHSNSSHHSRSSSARPDLDPAAGGNSRVDPQGGPYATHTRSPNMPAEPHPEHRSRRHDTHEHPHAHQVPHPHVEIPQQNLPVSPPMLSPTAHHRGGGSRTHNHQRIGPGANIHRERDPERDWELQQQLEFDRQLEREREAQRAIELRHRLALEQQEEEALWAEEERRARAHSRSGSPGSTARAGGSRDTSLPAPGQGYDHDRAPQRAHAPHVSNLLGIEREPGFKDDERGMNAARNRLSTNELSQSSSLESRKRSRDEMEVDDRYDSEGRPANEGRSSSRGLANLGGNRGGKRSHSDEDGDGGHPGSGKGDSLSDERMEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVE7</accession>
    <name>A0A2G8SVE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVE7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="93" mass="9943" checksum="8EBE5FB15210602D" modified="2018-01-31" version="1">MDRPGRANNVENCGAIPLSPSHIARSPKGERRSQILPRALCLEPHSGAVVGSGRGLTEAIFDTAGLRSKTRDAAVRAPREAREFRGTIAMDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLD5</accession>
    <name>A0A2G8RLD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLD5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLD5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="113" mass="12188" checksum="1B878E7E78826BA9" modified="2018-01-31" version="1">MPVNVGDTHGNGALPVPRASTDGGSTLSVAPSTVQGASPQSWATTDSTMLSEGDKEAQLLYLSDQLKVENRIKEGAENLLRMSLTVSTRGWDLCDYTTILCYQAFAFRFSGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLJ7</accession>
    <name>A0A2G8RLJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLJ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLJ7"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF42">
        <property type="entry name" value="MMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="127" mass="13732" checksum="4F9BE220A2FE5C42" modified="2018-01-31" version="1">MTKQVVFSEEANPPLPFYSQAIISGKTIYVSGSIGIDRNSKLVEGGVQAQTRAAIENMTKVLQGAGVTRDAVLKCNIFLANLPRDFAPMNEVYLEYFPKNPPARTCIGVASLPLGADMEIECIAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLS6</accession>
    <name>A0A2G8RLS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLS6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLS6"/>
    <dbReference type="OrthoDB" id="3358956at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="460" mass="49744" checksum="E9EB2D869077F214" modified="2018-01-31" version="1">MSRHHDQLVRLLCNNDSTFSRAKAILHTASLKTIPGSGYDLGPGATGLPAICAYIAAEQLGDDEVDEKTAQAASCLKPKVFKTTLNTVRAALAAAAAATSPNKKSSRSVSYKQLVDEAKIGRKGIVTGWMNDAERALMNNREMRRRFGSAYDAITLSVFCWVCGLMGNKKVKPPTLADKYAIPRDQFDELTDALHEVCKEVAKSVQEDIAAIKAGTYAPKPPPVAIMPVSPTKVSAATLPPPIPVPSRSVSRSPSKSALRAPSVGLTPTKTPTHKRKVAFDGPIPEEDEDEEEFDVTATPSKRRKFSSPVKPFPSSATPRASSRLADAAAAREVALPPPFAPSPAAGPSTPRRQRTTPSQPSSTHSSRSVRSRSQTGSAPTTRSRNGKQRMSTVREDQLDAVPRRRCRPVFADQQQWLKGDSRLERELKPWQDKWQELVRRAGGDVWKAAAAAATVKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM90</accession>
    <name>A0A2G8RM90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM90"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM90"/>
    <dbReference type="OrthoDB" id="3367070at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="622" mass="66736" checksum="A10E56C40FB87AE8" modified="2018-01-31" version="1">MGFFSARRADDLHSPPNDDLTVARVIRSRFYGKNKGKERDPASSPASPAATPYTSPSLTLSSTSFSSKPPDKRSIVGSIRGPRPSTSTTTSRNWAGSSTAHSRRNGNASDMASPRTSTDIVTVTLAQRLNELATANSEGLLSDDEYRLLRQNLFERLASGSTIPTEEPLVPMSRPPPHTADPRISTFNERRSSSNFHVNPPVSARAPSVASKKSFTSTVTGLLRRATSRRIVSLPPDAHGSDTISVYSIVAAPPEHATLPRTISKQASESSLGTDAASTRLSRTFSRRKVIGAHTFSATDPGPSRSRTRSGSRTAPPSSYHASPTAGIESSYTHISIHDIPDDDQVESVQDIRHQIEVVEAEGRRLLDAFNGLELSTLTRQRRVKPPVIPPLPSHGTLSDGGWPAGTLSARPGKDFDAISFKSSGSGRTARSLRRTPSNGAKMRAVPSATSPLSAPPVLTHKASMSSVSSRGRNGGPPPTPLSGVHLLHPGLASSSSVNLARSTGHLPLETVEEGEGGDRPRLRLTTSRSGSMRRSSRWAEPTIMSPISSSARSEAGSTGSGGKRVASVAAAIDDEELMSMEHELADIRRRRVEVTGRYEARLEYLRARLKGAELREKIMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNK8</accession>
    <name>A0A2G8RNK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNK8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNK8"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="145" mass="16484" checksum="9C0A49FF47113564" modified="2018-01-31" version="1">MNANAGPSRLPLSAFIAEDMNEFVHAHATYRFVIFDEEEERPRLLIWLFKPSMRLSYAIPTQYVLAKSASIRAGKVLFKILDTAAAYSDLDGLLRRYPGFPQAEHLYYPRGICQRLAALLKESNGAYPENMRTMTGLDVGWLQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNM8</accession>
    <name>A0A2G8RNM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_14434</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNM8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNM8"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL23125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="99" mass="11036" checksum="E868D3228A5D30C2" modified="2018-01-31" version="1">MASGFGYHGGVPRCFAYWQEFSKCYAQTDVPSQCTAQADDYLECLHHTKEIARAKTVKNEFIRKAEHQAHDRRKAADILADGVIVGVGLIQRGEATHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNR4</accession>
    <name>A0A2G8RNR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNR4"/>
    <dbReference type="OrthoDB" id="2804702at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="118" mass="12685" checksum="418064DED26A980A" modified="2018-01-31" version="1">MAVHGIGSFSEPIVVSDEEDAAFVENELSRLTDSSSSSAYNSPPYGNSTSYPPKAPSPPPASLAPATPTSPVLGQKRKWTDMRDSIQASQLQHPADTSNSKQKKKKQRKELRDLTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNV0</accession>
    <name>A0A2G8RNV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_14504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNV0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNV0"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="62"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="62"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="202"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL23195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="508" mass="55134" checksum="AA01D38EBDF42129" modified="2018-01-31" version="1">MAAAPSVDPSASFAFAPNVTPGTFNDPPSPTDSSSDLLFPATEGGSAPRRAAHAKKKPENHIPRPPNAFILFRSSFIKNQHVSSEVETNHSTLSKIIGLTWQNLPHEERQVWHAKAKAALEEHKRKFPQYAFRPLHTKGKAPAEKRKVREVEPKDMKRCEKIAQLLIEGMKGAALDAAIQEFDKHHVPEVVTRFEAPITARHYRRSSSAPAPDSEHTPFLKQEEQTPSPSSSKPKPLKVRSSSSQPDATRSSPMYECPTPSPPSEADTESDYYSSPAPSSPYPQPPSSPYPQTPTYALAPQQPSFDFSTFTFNSADAAPAMSYQPCDPLDQQSAYEMYAPQDSQESFVSFDQPCLTINTSFGGSWPGTTSSSPLSSIPGTPQMYSAVHPPCDPTAVIDTCFHSLSEVYDPSADYLPQPQDPAHHHQLYSAGVPVSVPVPVPASAYCALHGHPHGMDCSGMDMAYGAAHAQDFGGVPPKDGFSPFYGRQALDAAVYAPASYMAPVPAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ07</accession>
    <name>A0A2G8RQ07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ07"/>
    <dbReference type="OrthoDB" id="3543113at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="276" mass="30377" checksum="468A7BD2EAD4CE13" modified="2018-01-31" version="1">MGLFTCARFHALESAHIHVTSSKEVHLRSGDITALLGLFYAAVSASHVRTLNLTMICISLQSDDDFPPLRDLLASILPLRDLRTFTLTGVLRVMPVDDADFVALARAWPTLERLNISDGTTSESAVSLGALHHFASACPSLQELSLPGLVYPVVGVHVIPEPPLASSPERPPHPLRQLRVRTVLVPKTDPQSISDESAEAFARYLLELFPNLDGWEYMPKPPRPREPSPEPGPPGRRRPGISMSSFVAYDGRWWAVARRIYALCAAREEAKLSFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR34</accession>
    <name>A0A2G8RR34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR34"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR34"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL23976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="24198" checksum="45121537323E8A99" modified="2018-01-31" version="1">MAEQATIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLSFSTNFGTICFNVWDTAGQEKFGGLRDGYYIQGQCGIIMFDVTSRITYKNVPNWHRDLERVCENIPIVLCGNKVDVKERKVKTGSVTFHRKKNIQYFEISAKSNYNFEKPFLWLARKLVGNPSLEFVAAPALAPAEVQVDAALMEQYQRELAQAESVPLPEEDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS06</accession>
    <name>A0A2G8RS06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_14049</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS06"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS06"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="32053" checksum="600F71F95E33B293" modified="2018-01-31" version="1">MLDAYMDPRNTYLLLELGTCGSVQDRILRTDGLPLEEARFYYSNLILGIEFLHSQGIIHRDIKADNLLISANGYAMITDFGVAHPEVINDNTNLPAARYAIDWWAAGVTLFDMLMNNLPFGIDTSEILANVQAQKVTYPWKQPVTVREHFKKVFVYDLDKRLGASSVKQKDGTFVNVELRECPLFESVDWQRLAGRVDPAPFVPDPMLDPSRQVHKRRLPKQRKLPEIRIKRPSHMLEYDQFRAEAERARKRRRIAEEEEELEDDIRAANTICAVSPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTH3</accession>
    <name>A0A2G8RTH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTH3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="101" mass="11578" checksum="B2B4CED3D3D44D77" modified="2018-01-31" version="1">MQLGQLLPDRLNDTLLERLQSIVITPYSELQVTQGLEVVAEQHRLEKLHCFDLAILLHILIQQLLLVPDVNDQHVKSCWKRLQKVRDTSPICSVDLKVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTN2</accession>
    <name>A0A2G8RTN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12747</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTN2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTN2"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="298"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="456" mass="50274" checksum="44D0E345A472315E" modified="2018-01-31" version="1">MSIKKLRVAICGGGVGGLVCAVALSRYLDIQVDVYESAGAFTEIGAGIGVWPRTWKILAALGLTDELSKIAIVPPAEQPQVAFNFRKGDQPEGVNFYTLTTPGGMLAFHRPDFHAVLLRHLSSQCHTYTSKRLVSYAHTLSPQPATKLYFRDGTTAVCDVLIGADGVKSSVRSAVVRELAAVAQAEGRVEDAERVLAAGPPKWSGTVAYRAVIPSDTLRRHAPCHQVLERPMLYLGKDSELTVYPISCGMLVNFAAFRSRYDKENTTFNGDWVQDVSREEFFADFTGWEPEVHSLIQAVQKVNRWAIHTTSPLPSFVSGRVALLGDAAHAMMPYQGAGAGQAIEDGYVLATLLGDSRTTLSTIDRALRAYDAVRRPFAQRVQASSRENGLLYTLNFPSLTFDRPVSRADREDFVRLGEIRSRVETNWQWAWTTTIDGDLNRALRMLDGPTPNRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTX4</accession>
    <name>A0A2G8RTX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_12853</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTX4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTX4"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="145"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="368" mass="40603" checksum="B0FBDEB8B1FD580E" modified="2018-01-31" version="1">MAFELRWGIISTGRIASDFVKDLLVDPATRNVSDVAHKVVAVGSRSTESAQKFIDAYIKGDNNVKPYSSYAGVFADKDVDAVYIGTPHTLHYENAVDALNAGKHVLCEKATTSNAAETKALIKLAKENNLFFMEALWTRFHPLTLELKKIAEEGALGDPVVLHADLSSDFHTENQPLTHRMLDPKLGGGALLDLGPYPMFWAMLALYEHPSNKNAKPTSVTGSIVKSTITDVDASTSWTVNFTEHLKAQAILTCSMVVPAAHFGAVIRYKNGVIKVAAPIYRPPSFTVQYFDSPGGNVVREETRAFSYVGGGWHFEADEVARCVKAGRIESDLWTHEKTIIMMETFDEVRRQGKYVLPEGVEKVDRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU13</accession>
    <name>A0A2G8RU13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_12894</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU13"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU13"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="250"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="309" mass="35309" checksum="5D50D405E6B3941D" modified="2018-01-31" version="1">MSAIREVKFLRELKHQNVIELLDVFSSKTNLNLVLEFLDTDLELVIKDRSLVFLPADIKSWMAMTFRGLEFCHRNFILHRDLKPNNLLIASDGQLKIADFGLARDFADPGYKMTCQVITRWYRPPELLWGCRYYSTAVDIWSVGCIFAELMLRTPYLPGETDMDQLKTIFRALGTPTEEDWPGHTKLHDYVPVGQFPKTPLRELFTAASADCLNLLSKCLIYDPKRRIGAKDALNHPYFFALPYPSHPSKLPKPAKKETGPPLEEVDGNVEMVGSGPAVRANPPNKLKRRRSSEDFGNRPVARRLDFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUN7</accession>
    <name>A0A2G8RUN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="14">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PIF1</name>
        <name evidence="17" type="ORF">GSI_13098</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="14"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUN7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUN7"/>
    <dbReference type="OrthoDB" id="432234at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18037">
        <property type="entry name" value="DEXSc_Pif1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001226">
        <property type="entry name" value="ATP-dependent DNA helicase PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03176">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010285">
        <property type="entry name" value="DNA_helicase_pif1-like_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049163">
        <property type="entry name" value="Pif1-like_2B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051055">
        <property type="entry name" value="PIF1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048293">
        <property type="entry name" value="PIF1_RRM3_pfh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47642:SF5">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05970">
        <property type="entry name" value="PIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21530">
        <property type="entry name" value="Pif1_2B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="166"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="DNA-binding region" evidence="14">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL25209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="608" mass="66288" checksum="13C50DCED5B7097C" modified="2018-01-31" version="1">MSKAKQPMSGLRSIKRDFSSGSLPSIASQESLSSDPDTIPWQPTPPKKLSGLEQRLKDIQDALNAQVSSSETVLASSQSQKRPSTSQDPPAKRRQLPASWNEKLQAAPQAARPAYSSASSQRAFGKARQTNTNETLVVAAKSGSAAKPSPVFLSQEQTHILKLVESGLSLFYTGSAGAGKSVLLREIIRTMRKKHRTAADAVAVTASTGIAACNVGGVTIHSFAGVGIGADSLDGLVSKVQKNKKATARWLRTKVLIIDEVSMVDGDLFDKLAQIGSRIRKNPAPFGGIQVVVTGDFFQLPPVTKGSQGVKFAFEAQMWPETVKKTFNLTKVFRQRDPEFVDMLNEMRFGRLSEESIAKFRRLEREIVYEDGLGATELFPRREDVERSNGVRMGGITGKEQLYTASDGGSITDQQQRDKMLGNFMAPKRLVLKEGAQVMLIKNLDDTLVNGTMGKVLRFVDPSAPLENEDDILGGKPVSKGKDAKPSLGMRTLLPVVEFLQPGGARRTMIVSADTWKVELPSGEVQVSRVQLPLILSWAMSIHKSQGQTLERVKVDLARVFEKGQAYVALSRATSLDGLQVLHFDPAKVNAHPKVVEWSRSLETIAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV21</accession>
    <name>A0A2G8RV21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV21"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV21"/>
    <dbReference type="OrthoDB" id="2790700at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="39"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="265"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="630"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="761"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="697"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL25360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="807" mass="88640" checksum="F9EA024A9E175BD9" modified="2018-01-31" version="1">MTGAPASFVWSSPEGYRLARTILRPSLPFDPHDYQLEGVCKVLDGYDLLAVIPTGAGKTGYLLIYILLLIALSNNPNLCSPARTGIPRDPGMLIAYPTIGLEEEMAIVFERFKVKTLVINSNTLQVARRERRDLWSAAVQGYSLILLSPELLSSPGFETLLQRPTFQARLCALGVDEVHLLNSWGTGFRKAFLQLGYMRARMRETVRLIGLSASILAGQPLKSVCEFLGLRGGQFYFLQRSNIRPELQLLFRPLSHGLGGWKFPDFRWILDERRKTVIFCRTIALSFRLACYLLHLSTSSPSPIRLYNSLNWPSYNTRTRELMRNDPNIYIIIATASFMVGVDLPNIQDVILVQEPENADEWVQWGGRAGRDSSLVKDARVITYVTKKGPKTAQSLLEGDSSGSSASAVQTAKKGSTPAMDVSSAKVIIAQCKVAAQNELYNNPARDEPCTCATCTVHPRPPLPIPCKCSGCTPEASTMNVPPQKPSGKTNPVPRSKRLTRVMRRHGTQRLEKLREEIYDSLEDSASSRALPPTVYLPQPVITSLLDNFALLLTVDDLRALLLGRTYVLPHINKLWLALQALRPEFDDIRIKAAEERKRKAAEKAAQHAAAASKSTMTPEELEAAMQAVLDEDSEESDDGLDFFRQPRNSEVSEATDTDTRAAAQICTAETVTPNARTEPLYAAPHSDMDSTMLPPSTSDCSTSGSSSLSVLTAGLVPLTTAGAAMNTVPRRTRGQVGGGSASTQIRVEAVEEGPGYAMHILTFGGSDADPPPQARRKRAAPQKVDQAGNKPPRKRRRTSDKENCVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV49</accession>
    <name>A0A2G8RV49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV49"/>
    <dbReference type="OrthoDB" id="2801388at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="77" mass="8703" checksum="D1CDF00D01EAA534" modified="2018-01-31" version="1">MPPRGASGAPSFDPIADSRSIIGFFEDLDFCLEQAGINDDAEKKGHAVRYVPDLEKTIWRAFPEYADDDSTYEDFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV81</accession>
    <name>A0A2G8RV81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV81"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV81"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="712" mass="77724" checksum="603502E027D9163F" modified="2018-01-31" version="1">MRAADPPPPPSSPPRKKRGRKGKGKPAAEKDDILALHAADIEDVTMADVTVTHAGQGTSERHRKKGSASKPGATSKRKLDETESEVEVASEVPTGDLPSDDDQLSELSWLDDLDPNAQSTPKAALKPPRKKAREAVDTPVMSQSGDPMVNATQVLGASRSKLPAGGPAGASSDFQMDDDNFAAWMGILPEPAAPKAASRSASRADARGSSSTSRMVSSSVRTPSSGNSSSLSSEVVPRAARPVDTLPLRTKALAPKALTNPPKPSQKQPFQPDEGPARGQTGRKSTKKTSGAVESDNEEPERKAALSSPPKGGARPTSSHVVKIKEEQTSPRPSKLSINVVEPTPRKIDQVSKKSVDKTRGRTGKGKQKAVSESENEDSSDVEIVEDAPQTLKPPRSQNKSRSRSRSRSRSHSASPRSSRTWRWEDLPEGSQRRWKSYVLPTLLRFQGAQRDPWTFPDVSSVPTMQRIWDAVYGDELPHEVVAGDCVHGFAGQCLANWRSAIRAASEAVVGTFFHDVASPSQRTKDGREVLSRRILLHDRFLFEKPFDEENKRLFRSKFFLTILGWHLEATRGAVDIPGLFVKPLHPDRPIGAFGLAAAALERIFMLFEKRLMDPPPVSKDGKPTILWRVVAQVNPGTGVLSTSQTRFTERRFSSRTMRFIEAVEKMTPRRFNAALVDAQGYTGHKRLTIKDAFTEAPNNEEEAPLEDGDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVE9</accession>
    <name>A0A2G8RVE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13373</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVE9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVE9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013423370" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="554" mass="59238" checksum="15E251A3024CF921" modified="2018-01-31" version="1">MVFPSGFASFLPFFLSLAPFSTLDGDVPPTVRLDQATVYGTTNGSVTSYFNIPFAEPPIGDLRLRLPKPIDNYNGTINATQVGPQCIQQPSLALRQDMPAEMLRDIIAALNAGSVKPVPGSEDCLNLNVLVPTGTTEGAKLPVVAFIYGGAFSTGSNTQYNGAVMVQRSIEMGQPIIFAAMNYRLHTYGFLGGQEVKDAGVGNIGLQDQREALRWVKKRIAAFGGDPDKVTIWGPSAGGSSVGSQLVANGGDDEGLFRAAVLSCGSLVPTGDLSEQQRSFDIVVEGTGCSGAADKLECLRGVPAENLTTAAAAIPNVFDYPGLSAAEWFPHADGVFIKEPVHEAVLAGRIANVPFIAGDSLDEGTAFATGAWNITTDDEFLDYLRDLYFPGASSEEVAPLLALYPSDPAQGSPFGTGNANQLAPMYKRVSAFQGDFGFQAQRRTLLTLRSGKQPAWAYMVERRRAEGLGYPHGRDLVSMSNGEELTDYVIQFATTLDPNGGSGSNRTIPWPRYDPAARQMLLVLDGEEPLAIGRDDAREEAMEFIVALSLKYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVV1</accession>
    <name>A0A2G8RVV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ty3 transposon capsid-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVV1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVV1"/>
    <dbReference type="OrthoDB" id="2755464at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045358">
        <property type="entry name" value="Ty3_capsid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19259">
        <property type="entry name" value="Ty3_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ty3 transposon capsid-like protein" evidence="2">
        <location>
            <begin position="172"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="458" mass="50989" checksum="FE15E8F5E8848C9F" modified="2018-01-31" version="1">MSVYDGQSDVFPPGSFYFPLQSQGPVLSQVSAQGLPPPQMQSQPTAEDYARLSTQMQAQHAQHLQEEANAAAQARAASSQLPFDEQTTLRELFQAVVNANHENTALRAHSDRQDELIEALRVRVAEGNEQSIRFARDVFDEATHAIHNAPGPSGSGSNVGSGSAPARSSTVKLREPAKFKGKADEVENFIRDVSVNIRLQGSAFAPDQNKVEYFSMYLEKGSPLSWYNAITRQQPHLLHNWSQFLVEFIRRFQTTDLISKYTRKVEALEQKGSVADLVNQFQECLAYLHWSEQTKIVLFRRKLKPDLRRSIMDIPVPATFDEWAPLVIDRDNQLHELEIDLKRDDKAKAKSSSNAHRDRSCDRHGSTSNWRSSPSTQPASQPQSGSDPYGPAPMDVDATRHPRGLLTPEEKARRAEKGLCPYCGGSHKLQDCAKRPASKSSSSEKKSDKKADPGKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWN7</accession>
    <name>A0A2G8RWN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWN7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWN7"/>
    <dbReference type="OrthoDB" id="3054497at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="222"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="436" mass="50359" checksum="6D998E64553ED6B5" modified="2018-01-31" version="1">MSHAVLPQNLPQRARVRRETSHLHQLRLYPLYLLNLVHSTERTYQKCNTLCRRNLLRLTGQARKNRDGLRESGKYQFAKAMSMRSAERDPPVPIPPSMHTHREPTPVISSSSSDDEEEEDMGSDPIPAFVLPQPESPAPSPDRSDPDDDDDDDDDEEEESEEESSGQSSDEVEANPPDEGEKVPPANVREWTYRDIASLPNAERKEWFTACREELEALRRRDVYDLVDRPKGRKVVKNRWVFDVKTDGRKKARLLAKGFSQVEGEDFDKIFSPVVCFETVRLIMALAALKDWHISGLDVRSAYLYGKLDEEIYLEQPEGFRIPGSEHKVFRLKRALYGLKQAGLAWWRTLSESMKLMGYKRLTNDAGLYIYKRHSDGELVVVIVYVDDALFCGRDKKLVALLKARFMKKWECRDLGDAKEFLRMRITRIGRKIFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX99</accession>
    <name>A0A2G8RX99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11896</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX99"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX99"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL26141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="161" mass="18394" checksum="66B791A72F782BE8" modified="2018-01-31" version="1">MDHNLTQRRRGLEEKIPDIKKTLAMVEFLQDRREGGSATKDEDDLDDELEEGEDAGKPLTTTFELNDTLYAEAELEDTDTVYLWLGANVMLAYKIPAAVTLLRSKLDAAQSSLASVIEDLEFLREQITVMEVNIARVYNWDVKRRRELREKEAAEAKSENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXN9</accession>
    <name>A0A2G8RXN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXN9"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40080" checksum="AD31978AFFEB80A5" modified="2018-01-31" version="1">MSTRVTQDESRAVGDTKAGGDGNTGNGETCNKDTEFWFHDGTVILVARNVEFRVYEGLLAELSPVFKEIFEADGHPVRNVRMGKVQDFPCPVVHVSDSPEDLRCLLRACLSKRLSCLYDEQYPPYNDISAAIRLGDKYKITQLYSQALDYLKFYFPSSFNNWRELKDYTPPGWEKFEQIGVINLARLTGELSLLPSAFIACVWAESGKPELEGIGHGFTKEDGTRDLLSPGDLTVCFEAQSRLCRAAITTAMRTFKPVASPECKMPAACKKALRNVLLSLEQKVDEPVSGDPFTPYDHFVTAPGGLAVCPPCTDMVLERSKKERKAVWDRLPELLRIEVPGWVKEPQALPPPPQSQSGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXS7</accession>
    <name>A0A2G8RXS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXS7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXS7"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="31405" checksum="8DDD50E5ECEFB77D" modified="2018-01-31" version="1">MSNAGTTPAPPQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLASGTQPWADFAAFETAFKAHFCAADDKEAAIAELVKLCKGQHKIGTVQDYTVKFNAIAARTSFSAEDKRERYRTGLPYKIKDILATSGHDISSITKIQAVALTMDQNLLVREEERPKQFSGGWRKKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSGETTDLAALRAELKEIKERLSAVSVNETKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXY8</accession>
    <name>A0A2G8RXY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXY8"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="418" mass="45833" checksum="B3E19227686CCAB2" modified="2018-01-31" version="1">MTLAEASEGLNLLVVGTIFASFLIPTSVALFTFSPFTIWRSPLFILNVLAIILGLIEQGLYIYVIINTTAFGGVPTFLIIMIVAMDFLVPICVQGILLVRLVSVYPPKSNSRQQNLVIYIPVVAFKVARLVNASYATHDLIGHLPDSLGVIAAAQFIWRTKYVKVEWFLQLFDDMFVSGLFVHKLYASAMMRRGTDTATHSGSGSTYSWAERIRTLYYIALSNFVFPILFNIAEIVMIFTDPNFFHGATVVTVNCYVTIIGVLLATIWAQGSKGGRLRKHAVDYSYDPSTTVLASVEFARPQGGMDEDADEDGDEDEWTRAIPRKGPASRRQDQPPSLLTRGGEHALFKDIDGALDTVDEEAEGKRVSESSSSSAGAAESGPAYNDEKHVLVCSTLPATSTGRRETESHWGDPISNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY91</accession>
    <name>A0A2G8RY91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY91"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY91"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27893" checksum="5F6AC6A31509A204" modified="2018-01-31" version="1">MSAADANASSTHSMNYLKQHPEFWFDDGSIVLVAQDTGFRVYRGLLALQSTVFADMLAASNPSPGETVDGCPVIPLGDSPHDLVHLRVLLPASLVHYDISDPNQPHSFETISAVIRLADKYHIQSVQDHALRALQRYHFTSNFDAFSGPPDLVIAVKPIHAIGAVNLARLTNTPRMLPLALYQCCRLDNEALLAGWTRADGTVEHLTPEDFERCSAARARPSSRSTPRFTPRLSGRCTRARGVLPTRTARASAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYF1</accession>
    <name>A0A2G8RYF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYF1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="145" mass="15948" checksum="1BA330443F7ED124" modified="2018-01-31" version="1">MRLALSRTTWWTGTGGATGPSSTSLLQTRGARGMLAKQTAFYLKDVFEANPGARCAHTAQCARALDGIRDKVDINALGDCDIFTGYSDAGDIEGLAADSGLCKVCTKYMRQRDVAERRRVWLMLPEVFMMAVEDWGFTVEDGYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZP0</accession>
    <name>A0A2G8RZP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZP0"/>
    <dbReference type="OrthoDB" id="3353688at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="1">
        <location>
            <begin position="45"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="195" mass="20719" checksum="96B37C7DB4935FA3" modified="2018-01-31" version="1">MQNYGVTSLIGGDTPGTHSSDVFYMNHAGKFMLNDAAHSVLNATHPIQKIAVSSGAIVDGLSVTYQLEGGETTVMNHGSTFDPPSSVVSFGAHEVLAGVYGREGYITTYKRDMVNNIAFVIFDTSTEESRTVGPFGKSNQGQSFWESDVLALGSFGQNTTHYGLSGLFFYKNPTNTTNSAIMPASAQAGNLTALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0E9</accession>
    <name>A0A2G8S0E9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0E9"/>
    <dbReference type="OrthoDB" id="2754964at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="402" mass="44998" checksum="EAB1E9E9A8A793A1" modified="2018-01-31" version="1">MGLVRWTPERTPPVHLQVGDLALPEGTLAEEHKLDAVTRTDQRLLADDDKVALSQLAPEQVQGWCLSRIARYRNYNRLLREGYGGAARNVISKNKSHIRALHTAYNDAAPIHRHFPPEVLIEVFSHVDPVVTVMRRLQIPRATIPLFSGLEPSPTPHAELHVEFVNTNGGTVVHWETRGDNVRPVRVTVADGSASCADIVSNLTRALVAALAPARGLTTFTVGQWHTQIERYWDDLWPVLGARLRRLQILEYTRLGEFVQQLQLPRPVRTEGTGIPTCVCPVLEVLALKWVLPPRLDYGLDGDWRVLRDRDDGRHLGHRAVGLLPSLREFCDMLRACLSTRAAGGCSPLRRIEVTVYPRWVDRDAVGDHVVLQGWQIALVGERMRDKLGDLVADIAVTGGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1F8</accession>
    <name>A0A2G8S1F8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-N-acetylglucosaminidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_10753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1F8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1F8"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013890071" description="Alpha-N-acetylglucosaminidase" evidence="2">
        <location>
            <begin position="22"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="29"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="122"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="468"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="82689" checksum="36A58D0DEC9DDA65" modified="2018-01-31" version="1">MALPARILALLSFGLIAGAAAGSMASLDGIYALAKRRVPTHAHFFSFSFSSGEPDSFVISDVPQGIHVDCTTVSACARGLYTYLTQFGGTDIWWTGSRLTSLPIRLPKVGTPVKGQAIVPYRYHFNTVTFSYTTPFWIFDQWEFELDWLALRGVNLPLAWNGYEYILSETFREVGLTDADIASFLSGPAFQAWNRFGNIQSSWGGDLPTAWINDQFELQKQIVKRMTELGMTPVLPSFTGFVPRALPSLYPNASIINGSQWAGFPTALTNVTFLEPFDPLFTTMQKSFISKQNEAYGNASHIYTLDQYNENEPFSGDPAYLANISAGTFASLRAADPDAVWLMQGWLFYAEEGFWTDDRVEAYLGGVPGNDSMLILDLYSEAHPQWNRTASYYGKQWIWCELHGYGGNIGMEGNLDAITQGPVAALHAPGSSMKGMGLTMEGQEGDELIYDALLDQAWSPTPLDLTTYVDKWVARRYLKSPLPSAAVDAWRVLAATVYNNQDPGTQSTIKPIFELTPSLTGRANITGVRSTAIPYDTNATVLVAAHRLLQAHRQNPLLGSVPEFAYDVVDVTRQLLSNRFADRYTALVDAYNATDATPASVSAAGEPVLALLDDLDALLATNEHFLLSSWISDAKRWAHGDAAYERLLEYNARNQIALWGPDGEINDYASKSWAGVVGTYYKDRWAAFVDYLVETKKNGTAYDDAVVQAKNLAIGMEWCNETWGTGKGETWGTVGNPFEVAQKLVKKWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1K5</accession>
    <name>A0A2G8S1K5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1K5"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="703" mass="77605" checksum="1C90DB7113746F9D" modified="2018-01-31" version="1">MSRHQLEASQPGSELSDSLHPNGPHSTFGGLEENADQLRKRLGIPDLTTRTGLKKVHLDFDDCSHRLDECYASALANSDTTTAMLVCIIWTKIAADALLHEQLLCAGLITKLIPLLGMPRAGGLAENLFHFLIYKAGYKPAESAFELCRHNPAVLKTLRDHPGDQQIADFTIRTLAHGTLYTVSSQGPSDASIVDAIALKEVLSSLLGTLRDPGYLLEKTLELAMTILAKAPPVCPKESRLKDIPSLLAYYSALTRSRHFGARCNGALALLRLARIELDQAGNVDFEAQNRATAPSDRSAQRISCNHDQLLAGFPEDLQCLMETYGVDSCETVVEARRSSTVESALVQFREDNDARALGRCLAEHLQHSEFIVNPNDDSSDASGSGLKLTDVLESCIQSLSQSGSSEDLDAAAILELHSLLLKKQFQRALDRAEDELGRNPELGYARYAYCLALLDFFLRPRAINTALASNDLTPFLRRRLLFEAVKLLGEQGCWMLWEDGLATDEVTGPATAHFKEAIEKAELYLEMAPPDARQRSTVLNWYIVVRIVAESLDIHNDLSDYEPLLEQLRIAERFDEIRQDPPAKCDIQLAREWLFENYSDGTILEWERLTVRLGQMAVGSTSASSSSSKSRASAGFVRSSVEKYGQDEIESVLVVQKLNCVVEEVFALWKRVLLQSILPEVTLAQAQGILPKGTADIWADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1T4</accession>
    <name>A0A2G8S1T4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1T4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1T4"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta" evidence="1">
        <location>
            <begin position="34"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="263" mass="28052" checksum="D2F3CDBAC3C40E30" modified="2018-01-31" version="1">MSSNGRPSSTVSKIQKIQEKVTTANPNDPGYARQKQQGKLWVRERLATLLDPGSFNEVGFLTGKPLHDDMNGQLKNIVPANQLTGWARGKVDGRKVFVTADDFSVREAMHMVEYKGALATQYRALIRLLNGSSGGGSVASYLSAGATYIPPLAGLGQSMTAMTVVPVVSALLGPVVGLGSAKAVVSHFSVMIKGVSQLFAAGPPIVKQATFEDLSKEELGGWEIHGRNGTVDNVAPSELEAFQQIRTVLSFLCVNHSSNPLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2L1</accession>
    <name>A0A2G8S2L1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2L1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="198" mass="21649" checksum="5CCFAEE2E0BCEC7C" modified="2018-01-31" version="1">MWQGRVHRDIDVQNAAFAAIRRESQPRAVGRERKASHNASESENRPLSEGPSVPEPHGPILGSSRNRAAVRGPCARHDGRGICISFELGDFAARAPADVPNRHRPGFIVTGRNEIPTIRGEHEHRHDSIATVRDPALDCRSAGGVPEDDGRVPRSAGHPLAVRRDHEGLHPAVVLRRSGYKMATITFNFALHCAAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2L8</accession>
    <name>A0A2G8S2L8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Creatinase/aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_09866</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2L8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2L8"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF17">
        <property type="entry name" value="AMINOPEPTIDASE P, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="269"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="492"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL28015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="65012" checksum="9E4B4449420958EF" modified="2018-01-31" version="1">MRSAYLITDSRYWLQAGEQLDQNWVLVEAGGPSTNMKDWTEWVIDRAKDSKIGIDARLISFQTATALNNALKPKNSKLHYPPQNLVDLVWREKPSRSREPIYVQPNEFTGTGAGEKLTRLRAWIKEQRPAMPSYSRSEPKPSQMQVATLIANLSSIAWLLNLRGDDIPFNPVFHAYLFVGLESATLFIEESKLTEEVKGYLQSIGITWRDYNELWTFLRRKEWGEGNVIISPQTSYAICLMMTSFRYTVLPSFVEEMKAVKNDKEIHGLRNAYLRDGAAYVRWLAWLEQKIQQGYDITEYEAAWRLTEYRRKNKYYMGLAYENISATGTNAALPHYVPHKATAKMIERETPYLNDSGGQYRDGTCDTTRTVHFGRPSQDQCEAYTRVLQGHIAIDSAVFPEGTSGAKLDVLARKALWQDGLNYMHGTGHGFGSFLNVHEGPQSFSSDTVLVPGHVITNEPGFYLAGKWGMRIESALAVRRVKTKGQFNGDVWLGFERLTAVPIQTKMVREVMLSKEERQWLKDHNRRCLEQLEPFLREDKRAMRYLRREAERGIGIAGAGPGGLTIDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S322</accession>
    <name>A0A2G8S322_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S322"/>
    <dbReference type="OrthoDB" id="2758587at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="728" mass="81119" checksum="B73728EB0584CCEB" modified="2018-01-31" version="1">MLLILNAPRLRHKDVEQFYRIWRADAARFKSFVSRAPLLDPPAPDAPADKGKRKADIAFDNGEDVNGRASKRPAGKSPDARSSSQGSVSSFIGNIVHQAYVAFLPTDWTAPPPSEQATNSPRWQYQQADTDDLAYYLTRRGSAADVLPVPSQFQAEPGPSQIANLPDSLSPKWEEHNLVVHAPRAKAHPSSDIVANLELAVQSPGWMHDLKQPLQIVSFPSPTQPNATLDSSSFDIFNEMLWSLGNEQLPSGSTYKFDLGPVHPNGFLYTACMRLWPPNGREHDDLIPWTFTDYLLSLDICDASTWFYASKFEELKVTVSPEGTESLTHVPFETSMGNRNAPEYRKVLPEAPLERVEGTTRIALPHPGGSVLLRRWSDNFKVPFVPHTLRFKRGGEESDDERMTLPRILAYSVDMETACQPFDGRLGLAVPGFKGPWETGATAGEVRDQVTFWDTLCHNAPREKSHLEFTIRLLHPHPIHETYSPRSAGSFVFFGSKLPIEYLGYQGVSYVPSFTPPIPILPSPHMQGKYDLWAVRLLSITLCVPPMCQSDVRNAASPNWLSLPIKMPRHGVRAILDTASMNTTLPPSVIKAICSQWFQMDGLPVGTPISHASIDMFAGHRLLFTFAGAADGEEIPFYCDAMYFLGQLWEDTLFPGMLHWSHVRSSNDEQCDVAVLGQNFFWSAFVKFNAPYHDSPDSVPSIQLSPQRAIVDGRPLDGPWSLSFADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3I9</accession>
    <name>A0A2G8S3I9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3I9"/>
    <dbReference type="OrthoDB" id="2750120at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47366" checksum="E58ADC35CE7DE8F6" modified="2018-01-31" version="1">MRDTHEELKCTNDRWLCGIMSAAFLEDTLQAMPLLRSVSLQIRAREVHGIGWDSLAAILSTPQLRSFTVGTFLFSPREAPPETWAGDTLAPITTFRYEQRVFRSVLRAYPVQQDSLAFVLTRLHRSLESLLLPIEVAPMAVVAHTQWPQLRELSLNGEFHPSAEHTAPFISLFSGMPKLRVLNLTLALPKGVDRKQLLLWPGGYESGLPWPDLEALTISFPDPEDQIFAHLPPSLRRLSLRCTPHHCLMLEILRRSSTPLLDSLQLEYRADDADDDLLCCITERFPHVRVLEIHRFQASRDDPVPMTSIAKRLAALRSLHALRAHLELPPSVTARPPPEYRTARVKRYISKDTDALCEIAASLGSVLPQPGLAVWLLQQEVCGARWRRFRQIVKGSIDECPQAELDPRGDRELAVRVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3J8</accession>
    <name>A0A2G8S3J8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3J8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3J8"/>
    <dbReference type="OrthoDB" id="2756770at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF483">
        <property type="entry name" value="PEPTIDE SYNTHASE GLIP-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="419" mass="47588" checksum="C3435E10F099CEAE" modified="2018-01-31" version="1">MALAALEDWHISGLDVRSAYLYGKLDEEIYLEQPEGFRIPGSEHKVFRLKRALYGLKQAGLAWWRTLSESMKLMGYKRLTNDAGLYIYKRHSDGELVVVIVYVDDALFCGRDKKLVALLKARFMKKWECRDLGDAKEFLRMRITRIGRKIFLDQRAYLEKVLDRCGMMNARPALTPLPAGYIPAPNTGQATPELRSRYQKVIGSLLYLMLGTRPDLAFAVTKLAQHAANPTEDHLSKALHICRYLVGTKNYALVYNGDSQLGLIAGTDSDWASDPYTRRSQPGFMLKLANCAFSWVSRAQKTIALSSTEAEYMAMSDCSRQVVWVHNLLAELGYHIGRVPLSGDNQGSIHIGQNPVTESRSKHIDIRYHYIREVYDRGITDIFYVEGTNNPADIFTKNLGTVKFHHFRPYLGLHFPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3X2</accession>
    <name>A0A2G8S3X2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3X2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3X2"/>
    <dbReference type="OrthoDB" id="10631549at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="699" mass="77961" checksum="2128A1AC6ECA0213" modified="2018-01-31" version="1">MNHPVRQSSQLPSQAQFSSGHAPMQFSVRQSTPPQTQPNFSPHQYQQPATRPTARVTQTQSFTSLDGWHSYDPSEAHKAPQKKTKNNKKSTKPPTGTQKQVRIPEPVPANSAQHEGSGRSAATPPVPASTCPTAAPPVPDPIRPAGGRSSVPNPNTVSASAPSPIPMPPNSMESPTPPHSSRASATRLATSAAPRRLPHRGNLPLPDGRVPLTFCTKKTPEAEREFWHSLSLIDQQRVTNIYHEGNLQTATFTLGSADPTPHPQGQASSGVVPSENHRKGKGKEKELATEDATRKAPSESADRDRSKPSRTTAYQPATVEDVPEESDGGLSYASDSRPQESDRHPPMETRPRRTPPPFAVSSEDYYGSTHMSVKVLDAFHQTQERLDRLEGKISCILRTTGHQVHPARSKQSSARRRRPEAHPPTRSHLPSRQTHGDSDADDEDADEDEDDEDAEDQDDNDNDEEDEDGDEDEDEDDERALQELKALAREVKDKAHKTRHAEIVRKYMDLKLLKFSHTSELPTMFPRLTDKELSDYRANKYPPFSEEHFRICFVRQWIRCSWNFGAREFVVNFLIDICQRKAFTGVLTGPPLPRRFFTQKAMEKAVDSHVEYLRGQYKDHAGPLTPTKEAKLKKRKQDSGINRRKKTTLEARERTANRHGLVRHAALLKKLEPCHMSGDEAATTKPGAEATGNAHLWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3X9</accession>
    <name>A0A2G8S3X9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3X9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3X9"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="329" mass="37009" checksum="8857FBCDDA734D76" modified="2018-01-31" version="1">MYQSATVPERLLLWVYTNPARGTAYYKWHEAERVPALRDHMPPSTVFLACSRWVAADGAAPAYLSLYDLARGSAASAVHDPAYVALSEKHALETRAAAFVESRVYEPVVPPSPLALPTPPWTWTWSWNWMDGNGSEGTDESEDSGSDEERRRPQTRYISVIEADLHAFAEGEFCRWYDEEHILLLARVPGWVRSRRYVLKEKLEVGASDSDSDSERGLGGVGVGVATDTDAEMETATGSEGGNGDGSREEEEEKGRERENSKPKPGGREMEFEEHGADRPPKFLAIHEWASLDAFETKQYRRATNTPWRTEVLKEGRVLRYEIRVFRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S409</accession>
    <name>A0A2G8S409_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S409"/>
    <dbReference type="OrthoDB" id="3214103at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="140" mass="14836" checksum="D4305DD4670440F6" modified="2018-01-31" version="1">MRALLLLVESGTVYSIFLTVAVAYNGVSRSRSARTSDAQFVTATRTFLTACFAPILAIYPTIIIFVVALNRSLIDNDLANPASGIPSSIAFRSSPSAVHLTLPPGGANFSHSDHSLDSPGNQPIQTSRTQEKSEETAGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4S9</accession>
    <name>A0A2G8S4S9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4S9"/>
    <dbReference type="OrthoDB" id="2731295at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="224" mass="25438" checksum="2722FB877D10CEA2" modified="2018-01-31" version="1">MQPLPPWFAAPRPLFECPFYYRGDIIQLEHLLDLDPFPKILSLLSLNPGAFTVQDAPPDTSDGANDEVDPRLELLINLIGDLALSHESIRARLPIPHSHSPSPGEQALRHHSARARFPDRDPYPAARLSPATAVHAFKLFAHSQTFDPELLPPIELAHEFKQESCFRRYAKAFRARGHKYDLTHDAFCTLRRRLLRHRPGRKSRTSFCGEGSRTDALRPLPPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4V8</accession>
    <name>A0A2G8S4V8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4V8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4V8"/>
    <dbReference type="OrthoDB" id="3350156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="576" mass="62471" checksum="710803FCF08B9BEE" modified="2018-01-31" version="1">MFQMDTPEDHQPSTSVSTIRGFRALEMSMAASESAPAHDEHQDSHSPLRPSTPHSGYQSEPGSPSGDSISSFPSVGSSFLFSSGPTSPPHPAHHLEVEDADELGDSTSGLVIPSLTLPSPSRHPTVYGQTLGDVRLLLLGPRGADMSAVASQLVDDNEDVVEVGLWDEDRPVGVSTRGRRKSVLHVSTNWVEHRDRHGLERVEPARNVEIVELPPYDNYSEAQSIVERIIPIIHYPFREVLDILNHEHPPSGTLAHLLSSSCSPLYTALIMLATPSALSPIEKTLVESLSTHIPIIVLPPSTPFTLPSSHDHARRASSSHLSAFRPASLAALRAGLFRNPTTLATLRAEASSRFLRWREVERAVERVRWSAETSRPSVSSSVSHHRGSAFDINNSSSPSGAERHSNAKAEWFDKQAWEAQWDPQDSLSREVALHLRRRSEPPRRVARSGGGRRHSPLCCSAATADPLGEKSSLVTPPCGPGFDPLHLPSLVVFSFSLLGALRTRVARALGWKSGQDEGRRRPSIARRTSKEAPREEVASVRSGSGTGIKYTFGLGIALVSAFCAGVGIGLIAVTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4W4</accession>
    <name>A0A2G8S4W4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4W4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4W4"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="399" mass="44082" checksum="B6A16F3BE031E96F" modified="2018-01-31" version="1">MGVRTPRGSAVAAGVAKGKAKAKTDTKNPNNTRSRRRGTKVEREDDDDDDEAQVELEGLSGVESEEHDDASDAEVESLDSDALDDDDDDEQETGNNGKKRKRGTALSPKNKNGRRKAGSAGRAGTAAAKERSKAKAQAQGKGSPKKGRGGSARKKRKTAEDSEGEGEESELELEEGQEIVGVVVQAPKTGRVPPGQISQNTLDFLSELKKPECNDREWFKLHEPVYQLAETEWKAFVEHFTDVLVDVDPQIPHLPPKDVIHRIYRDVISSPEFEALFGPAKPRPNGGRQNIFGAEDELRVAPKGVDKTHKDIDILKCRSFAVFHTFTDKQVLSPDFKDELAAIVKVVRPFVHWYVDQRWSLEVVRRLTFAVWNVSLNDLMTLQDSASNSSDDESDVGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S578</accession>
    <name>A0A2G8S578_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S578"/>
    <dbReference type="OrthoDB" id="3178885at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.198.10">
        <property type="entry name" value="Delta-endotoxin CytB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035918">
        <property type="entry name" value="CytB_endotoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55676">
        <property type="entry name" value="CytB endotoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="192" mass="20956" checksum="A500917D07BE0C11" modified="2018-01-31" version="1">MSAKPLPDSLLHAGAKVMKLSNRFIIFGESQDIEGLDWPAFKDVVAAHPPHTLTLAKFESTSITNHAGSVDDMAGKIARYLYDTFSLEGIDNAGLRAHITAAFECVGKAESAGFFGSSTYEAHGTSWEYRIVFAVPNPSNPDWFYSVVTTIKLTADIYEHKGLFGIGNESRHNFSADITGMELSVNKDYADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5M0</accession>
    <name>A0A2G8S5M0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5M0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="116" mass="13378" checksum="E5B3AFCB27E7AAE6" modified="2018-01-31" version="1">MSTRRFPQSCPRMGSLLRPCRARSPSRLRLRATNHAGLHLRLWRRRTRNLDGDFQQVHPSGDVEDGGRWHHRDRLRWPHGCDYGVRLARPVSKASIRHGGRTVCRDGHRCDAAVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S606</accession>
    <name>A0A2G8S606_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S606"/>
    <dbReference type="OrthoDB" id="3068732at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="91" mass="10088" checksum="4502D64445AA8DF8" modified="2018-01-31" version="1">MPTNLVFFGVHLVMGKLYANSIMARPMMLPSVHYNPRSPPASRPPQQVDVGVGHPIHPSREASFVQPREFGREYKGRVETSGSNIPGEKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6C0</accession>
    <name>A0A2G8S6C0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6C0"/>
    <dbReference type="OrthoDB" id="2587912at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35794" checksum="1D54B9A98F9124B7" modified="2018-01-31" version="1">MSLAVMPVELLQEILALALRGHHRPAELLCVNKTFFKLGLPILHSHLDFHSIGQLILFSEGTIRLSCVPKTLSIALAGGSADFEIFKHMAAALRRCLLSTVTSQEDVDGNDLGGNDPRSDETKLPLELLSLRLHSHSGNPHLSYLYEALALANPKTFVWRGPDPEHHFSTAIVPSATYHLASAISTWTAVEHITLTNMSFPSDELGLHTSFSKAPLLPALPHLRTLYIGQATFLPPSAAAAMVAQPSSSALESVRLVDTYRHSIWGPRIRRRDIEDAAVLLTDVVAAGEERRREVLERVRRIVRCEKKTERIQGGDNGDEEGALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7K6</accession>
    <name>A0A2G8S7K6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_08152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7K6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7K6"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013970370" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="454"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL29714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="580" mass="61739" checksum="396AEB33FE30C432" modified="2018-01-31" version="1">MKSKAGAATLAVVGLTGQMMMAARAGSISAWAPCPQFGDLSCAYLDVPLDYHNASAGNGQLLVVKANATAAERKGTIFLNPGGPGVSGLSTLATDGDALMNRTGGAYDFVSWDPRGVGPYTYPGNVYCIPDDEFASFWNGTIEGTGINELGDFTNQTDLRALYSQAPVLDEKWRELGERCLAGPNATTLGYIGTAATVRDLVGLADAIVGENSTIDYWGLSYGTLVGAWFINMFPDRVGRVILDGVLDATRVASTQSYQLWRDQVGAAEDAYTGLATACALAGPDNCKLAPSANGTAQDVVDVLNDAIKASLPRQLGHDHPVQNLLTILRATMYSSLYQPQLWAQYGNELLPQAIATIQNSTADSASSLTKYVVSTVAPTLPLPSSHLPNEIAIVQRRRDAVYTQNSYTEVAVVCADSVDADPSVNTTVVFDDLVDVIRTVSPSFGALFPVPWQRCSYWPVRAPERFQGPFNGTFAHRVLVIGNAYDNATPFKEAAHMAEVLGDQAALVKQNSFGHTSIYQYSTCVADIIKAYLQDGTLPSGTSSNPTVCDIDDDVELFPGVKAVDVIAQVGATDLSARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7N0</accession>
    <name>A0A2G8S7N0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08176</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7N0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7N0"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="431" mass="46779" checksum="216DEDACAA66DBE2" modified="2018-01-31" version="1">MANTAEFLENFRGPVLREVLLELGPVQSIVAITRDDLSAYTSSDEDGLQSGVYGGLESILLKFALPRITWIIDTPLSPSTGHDDRVTSLALSPDGNWAASASDDSTIILWDTSHRGVMTFAQQWVAHGYLEVLSLAFSPDSRHLLSHGEDGKAAIWDLSQSPLAGIRRAGTLEGASGSRVSSCAWCPDGSTLASGLWDGTVRLWDAHTFLPLRTLDRGSSALTTFPPSGHWLLSGSPPASFCVWDAETGRLHRVLESGLRADQPPRHEDQPMAAAFHPGGAYVAVTCGADSLAVWDIERGEPRLVRVLERLGRVDDVAFSPDGTLLLAVLDRRVLVWDFGTGEARIPFQAPGRGAVRGACFSRCGEYVASVSGDKEVWLWRIGDGQGRPMLEYEHAMEHVVFSTDGKTLLCGTVDDMWDGRRERASDPPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7U0</accession>
    <name>A0A2G8S7U0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase eta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_08053</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7U0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7U0"/>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000008">
        <property type="entry name" value="DNA polymerase eta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UmuC" evidence="11">
        <location>
            <begin position="55"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="196"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="539"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="686"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL29846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="728" mass="80567" checksum="D14920202AD1DEEA" modified="2018-01-31" version="1">MASTAGGNSSKPPSTSYWKGKGRATEHDFDDLNPTITYRHLLSSNLGVRDPLRVIALCDSDAFYAACEQVRLGIDPTLPLVVQQWEALIAVNYPARKYDISRMDKVRDAKKRCPHLVVVHVATYKEGEPEPGYWKNPDTRTHKVSLDHYRRESMKIIQMFKEGLPDGEVEKASIDEAFIDFTRPVREELLRRYPHLASVPPDEPNGLDTPLPPPPPISWEGKGTIVPVIPGKEEPKAEEVKPPNGESSIEDESLATEEASNASGPEDEEDAVEEDDEETTWHDVALSIAGELMMRIREDIRTKLGYTTSAGLARNKFLAKLTASYKKPMNQTILRNSAIPNYLKPMPFQKIRFLGGKLGKALAEEYDVSTVSDLLTISLEEMQRKFGENSIWVYEILRGIDRSEVKEKSAVNKSMLASKNLPKPITKAAEGQHWLRVLAAELALRLNEAREADPALWPRTIVLHIRQGYETARSKQLPFPFTRSVTTDVIASFGNKLWKELVGTAGSTPFKITSVQLSFSGIGSMEAGQRRIEGFFAARGGSDDQNASESDAVTSVSDSNGKPPSKRTMRDTSKPPSKRQRSGSSTNNHPETASGKRHDAGELEDQDMRSDLSARVRDVRYSFLCQKCHKRIWLADAPAVSQVEGDSDGSGAGETADDAIREDALAALRLEHADFHFAEELAAAGDDRAPKRVIRPADRPASSSTVTAKKGQKKAANHGIAKFFSRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S826</accession>
    <name>A0A2G8S826_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_07840</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S826"/>
    <dbReference type="STRING" id="1077348.A0A2G8S826"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="417"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="605"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1055"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL29929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1109" mass="123668" checksum="5B9E62BE01D50180" modified="2018-01-31" version="1">MASSPKGEDEFIHHIAIELSRAMNLVNPNDLLARRVQDIAKNNSVDGFIEAAKSFGKFKPSFLAELHAEIVSHAKQEATGQQPVQGIVVHDSDVLEPEPVRQGGLMRKDAKHTFRQPAKPLAPPTPRTSVLGLDRLAQEKRAAANAANGEGSRKRARLDGDGDGPVFKGEDGEGALGLDAREWEEEQTRLDRDWYMGAEEGAVMGDEEYNPLSQYDDLAAVKEEQMAKKQVKKISARQAQYNADNDLWEANRMVTSGVATRKEIDLDFEEESESTVHVMVHDLKPPFLDGRTVFTKQLDPINPVRDPTSDMAIFSRKGSGLVKEKREQAERAKAAAKLAALGGTQLGNIMGVKDEEMEAEAAAEEKAKQEKEEDYKGDSKFASHLKTAAGVSVFARTRTLKEQREYLPAFACREELMKVIRENQVIVVVGETGSGKTTQLAQFLYEDGYCSFGIIGCTQPRRVAAMSVAKRVSEEMECKLGSTVGYAIRFEDCTSPETKIKYMTDGVLLRESLNEGDLDRYSVIILDEAHERSLSTDVLMGLLRKILSRRRDLKLIVTSATMNAEKFSNFYGNAPTFTIPGRTFPVEIFHSKSPCEDYVDSAVKQVLQIHLSLPPGDILVFMTGQEDIEVTCQVVQERLSQLDDPAPLAVLPIYSQMPADLQAKIFEPTPDGRRKVIVATNIAETSLTVDGILFVVDAGYSKLKVYNPKVGMDALQITPISQANANQRTGRAGRTGSGFCYRLYTEMAFRNEMFANNIPEIQRTNLANTVLLLKSLGVKDLLEFDFMDPPPQANMLNSMYQLWVLGALDNIGDLTPIGRKMSEFPMEPSMAKMLIQSVEYKCSGEMLTIVSMLSVPSVFYRPKERMEEADAAREKFNVPESDHLTLLNVFNQWKAHGFRDDWSMRHFLHPKLLRKAREVRAQLEDIMKFQKMEIISAGTDFDVIRKAITAGYFHQAARVKGIGEFVNIRTGLPTHLHPTSALYGLGYTPTYVVYHELILTSKEYMTQVTAVDAYWLAELGSVFYSVKEKNFDERGNRRKADREFSKRAELEAEMARQREESAKRAQEEALAVQTSSGSAKNIIVPGTPRHTGVGAGARVTATPRRRVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S843</accession>
    <name>A0A2G8S843_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S843"/>
    <dbReference type="STRING" id="1077348.A0A2G8S843"/>
    <dbReference type="OrthoDB" id="2749208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="851" mass="93951" checksum="F61BDA5B89F90AA3" modified="2018-01-31" version="1">MYQRWDNASPDLGTLLMNATRSAASHLYLSMIPFVDRRFSTKLLVSISAVGPQGTFHLATLPFHTPNTFTAAPGWDNAYATFLGSILGDSSSFSAVREVWISGVYPEAHYHTRIAAAFREAIAGLQALETFVLVEPPRSFPHAVPTISLCPDAQGSAPVPPNLRTLRLVCEDGAHWGRSGGGNRLRLGVLLAELETGAYAYFDTLVLELRSWLDVTPEDLVQLKAHFATVTCLHVDQSQTGRPLPDYCVESCGGPGGTGTLLGARLMEVANTLTELAATLREELNSRSALFKLPVELLQKILEQVPHPFFRAPGPFVRDTDEFRPSWRSSAKNTYMLMPVLQTCRQLRRISLSHKSLWKTIDPTGRYSLPSILLQKGCDAPLIVVIDASRASDGSGEALGNLDEGDVQRMQELHVFELYIHRLPEDNAEKIYRYFNASMPLLESLSISQVFTSEPPDWHIDEGECPFPLDHAPRLRHMMLHDVTFTPRNGLPHLTHLSLAGISTPNIHIDTVNLLSRCSSLETLAIYSPYLSDTLPNLSEGLSRPLNLNRLRRLTLQLPCRLAMEFYLSLFPLDSPTLQPTAVQILEFAASDMVPVLGQTLRRVTKAEASHLSLALHPHPQYRNQRYLSFTAAGPEGTFHISTDTYHVDVVPLGDLDVLPQLFLDTFNILSGCAHLRAVREVWVTSVPPQTGRRFFRDVMGHFKSIIAALPALETVVVVVPAAGAQLETDLGVLPSTHDPGFVAPSSSLKNLRIVHGTDAPTGRESVEKIRLTGLLDQIGSAGAYGYFENVVLQMTRQLEVDEEDLARLEACFKNVSFQHVDSMPAMPLPEYCTEPYAGPGGTSTWHGSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S919</accession>
    <name>A0A2G8S919_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S919"/>
    <dbReference type="OrthoDB" id="2687169at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="416" mass="45887" checksum="3F73D3DABBBCD4EF" modified="2018-01-31" version="1">MSQEPKKFKIAELPSTPSRSVINALQIIIDRLGPRDPDSSTQMAQLSSNFDSLNISRGSQSSLLPPFSRPSQPDARSAQVVNLAQALTAKLQRHLRKRATEYHYAALQAFLPCNDLPGHSLKLRCLPFKPDGKQRARERGAHEVEGNPLTLEMTEHLVNLAYRHTSHNTDLGFRLVTEIILLRLAAVLRASAESDDIRLLTDCPVRAVELPGEDPSQLSGGVVDYILAKHQHRAPRTSTAAGTLAEDIAGTLPSFQKIGAANIFYVSSVLEVTYGLPHSESPLSHAFLLCSALNFDYEFSCRSGQEAMRAAVTNGESWLFLAYKRSAESPGAGYYAASELFDVRVAEDTLHVDWILGVLIDWVRAARGSFPAPTPPLYISLYDAATLTNERQVENTGNCDAFEYFEDPAWDIPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9E3</accession>
    <name>A0A2G8S9E3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9E3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9E3"/>
    <dbReference type="OrthoDB" id="2724111at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30334" checksum="FC2094A43CFD38D6" modified="2018-01-31" version="1">MDKCPNEVLALIFAEACTDDGLAGRSLSLVSRRVHDISRRHALQSVALYGFYQLSTFASLLDKSDPEDRNIRHLYVSDRPRGWIEYLPGQGREDWLATRVDEHFHFDDPSPNHSTSSLLHILKTVSPTLETLALLLFDRYDKQPLSDALCLPKLRELTLHGSNLTRPDHSELAQCLALRRLHVVQNVSIRGSMTKAVSHLAPLLTHLRISRIVANRFASGDIVLGLESMLQQDDLASTGFPPTLKCVLVQMLRVGTQDRNGRAAVRVCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAG4</accession>
    <name>A0A2G8SAG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAG4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="125" mass="14072" checksum="6998958884935E49" modified="2018-01-31" version="1">MLALRRLPRYAPRLTHIRGNATLEAASASQAQASAPPPPPPVTAKTATPPAAKEAAPEEPTEDTTQSEQPKGKQREWPKRRPPISLERPREWNRPIAKGVEPAYDYALRYILRDAQFLRARSWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAN9</accession>
    <name>A0A2G8SAN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Splicing factor 3B subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_07370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAN9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAN9"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000059">
        <property type="entry name" value="splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="99"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="313"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL30668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="342" mass="36708" checksum="DC6B7A0581B72232" modified="2018-01-31" version="1">MSRPQDDRNQEATVYLGNLDERCSDALIWELMLQAGPVVNVHLPKDRISMAHQGYGFCEFLTEEDAEYACKIMNQIKLWGKPIRVNKASSDKKQLDVGANLFIGNLDENVDERLLYDTFSAFGTMATTAKIARDPQSGKSKGYGFVSYTDFESSDAAVESMNGQFLMNKAITAQYAFKKDGKGERHGTPAERLLAAQARKNNALPVAARPPPAPMGAFGARPPMPGYPQGPYQGQFAGALAAAPPPPPAGFTPQQTIVPQGMPQGMPMPPPPMQGMPPQGMMGVPPPPPPGVPVYNPQAGFAPPPPPPGYVPQGMPGMMPPPMMGPPGGMPPPQYMPPPQQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAS9</accession>
    <name>A0A2G8SAS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAS9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAS9"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="552" mass="60816" checksum="378D0B8FC4AEC31E" modified="2018-01-31" version="1">MPISLAESLLPQPPSFQKKKAYEIHQVLGVGSFGKVMRATWHVPSGQMNVALRGAAASGDTNVPPGSKPIPSRTNSIGSSTLSPTSHLASFAKAVKGSPSANDEGFSVEVALKVIPKKKVKGNESSVWGEMEVLRGLDHPNIVKFYEWFESRTKYYLAFELAQGGELFERITRKGKFTESDAVEVLQSILSGVKYLHDHDIVHRDLKPENILYRTQEEHSDIVIADFGIAKHLHTPEEQLHSLAGSFGYVAPEVLNKKGHGKAVDIWSTGIITYVMLCGYSPFRSDDMKELIRETTEAKIEFHERYWSNVSDVAKDFVKALLNPDPSKRPTAEEALNHHWLTSHRPSTEHDLTGLREHFDPRARWRAAIAGARALHRFSLASSRTPSGSGSSGGWRTGSFVDSGDDDDDDDNPRPMRAVPEAHGHGHGAAGSPHEETHSESEYVKVTAPEEDEQEHPQPKHAAEPSVSKPPPEPISTLPQPSPAPVPAQAQTQAQEAAAPPQSAQPVERGRVTPELKMPGSFDVPEDQYHHNHHHVWEGGLMGLFNSMHIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBE7</accession>
    <name>A0A2G8SBE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBE7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBE7"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="71"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="520" mass="57032" checksum="CFAC85D7446CFCFB" modified="2018-01-31" version="1">MPFGILDDKKLDNVPGTDLLSDRGRSFLATIDEGRDLKRGTGKNSHIILIPQPSDDPCDPLNWPRWRKEACFWTLVFTSGLTGALFSIASAGFLVLAKHFEVSVDTVASALTTYAPALAISILFQNTLAVKYGLRIVYLGSTFLIFIGCLWTALSPNLTSIRVSRIFQGFGMAPAQCLIATTLEHIYFVHERGSRSIIWNFALIGGTTLGPFIYGYVIQHLSWQLGFWFASIACGLSFVCVFCFVPETTRHRQAPQIQVLSPNKQDTSSDVNDKNIGTESPQSETSPFLSRLKVYNGTFSDESFWKIFTRSFTLIASPVGLTHLGSLVGVVLAMLLTGPLSDRTIVWMSQRNRGVYEPEFRLVLMLTMLFGVFGYVGWAVGDDNHMPWIGAVACFAMVTFGLVASSGAAVTYLLDTHGSNAQHILSLVRCANYLILYGSTFVDNAIVVSRGIKVSLLILGACQAACWLATLPMYVYGKRVRSFIARHPRLFRGAPLAGPAPESDSTQSEPTAGPEIDAKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBJ8</accession>
    <name>A0A2G8SBJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBJ8"/>
    <dbReference type="OrthoDB" id="10425778at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="280" mass="31389" checksum="E2BD4D782D7395D2" modified="2018-01-31" version="1">MQSQCTVPRKHVPVPLDERSVARMKAAAAKVPGCGKLRPRSYMGQDGAGWSFQNLFDLHKTWPTLKAEIPHGKDSGLQSLGYTSIDFILFWPGYDPRGFVFNIKLGSAPVPGVRDYADLVLEIARCYDAFFRFYRAENILPNWDIKRNPHFMVENLGLVEIRHAGANVFYADIEYQPNVQVPKPATPPPPKSLPSITQKDVENDPVFRTPDKVSPEAAVLFKAFGERFPYPSEMQCTRVGAVVGYDVTLTKIWFENNGYSNALPCVAPRTRLSRAAASRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBW5</accession>
    <name>A0A2G8SBW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBW5"/>
    <dbReference type="OrthoDB" id="3245714at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="258" mass="27949" checksum="EEC2DA6D4A1F1564" modified="2018-01-31" version="1">MPVFTTSSALRARRGSRTPSLPLNVNTAPTQPTSDATPASPNATQPVSPFLESESIVLKAKRAYDRDRQRAKKRKERAERERERTAALAPVPAVHSREGSTKHAGRGNAKPKLVTAEDKDVAVRPLPTSPVEEIIADVVERAMLARGDAAVSVRVVTASKPREVDLEQLMKPAKARKSKGESILVSGLNVKLGRDANASMRPAGDFEVVSDMPVVIALDDQIPDDAELDEPWEHISADELDEKRESPPSYATVLANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDK6</accession>
    <name>A0A2G8SDK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDK6"/>
    <dbReference type="OrthoDB" id="2753605at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="339" mass="37620" checksum="1C451BC121C1E0BF" modified="2018-01-31" version="1">MSGLEKLPLDLSRPAKPLFLKPRGFHLRSLPIYDVHNMVANSSLTADAFTHILKHCKPTTLVQCAGTSLEFRGLVVSELHRRYFFLLRIFFGPHAPEFDNLLRIHSAIVSGSTALAFFSWTDSWRPGDMDVYVGDIAYAEFVHDLERRNLATLDTDFDYHTPTSYHGISHVRRYVTTSGERLDVIQSRTANPVSPLLYFWSSVVVNFLSPSGAVCFFPKTTLEHGGFFTNVSSSKLLAAKEKYESRGFRLTQVPTWRPARGTSTHGTEILTEKPILVHDFLSLLPGEPSVSQITRDGQAWALTLPSAPAVSGTRSLPSLQMFAPTDNPPSASAGLNQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDT5</accession>
    <name>A0A2G8SDT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDT5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDT5"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037847">
        <property type="entry name" value="GRAMDC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37402:SF1">
        <property type="entry name" value="GRAM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="696" mass="75366" checksum="2ADC473DEDD9B974" modified="2018-01-31" version="1">MSGNGEHDAGRLRPPMHPTQSSTSHSIPLSPASSPPPPPTHASQPSAHPDTSLPEGSIAQPPSLLPRPSASSPSVSPSSGFSPPAQFVPLEQDQGLDGEVEATTSAVHQTGLGVGPSSEALSSAGSKDEEELSEVQLRELYDDEEIDRFLKVFSTYVREVRTTQPIQVGTTHAGEPASFRVATIAGEDVSPPTSVGEAPAVETSWDRPLSERIAVELVVPLLPPPRSPPPDFSLGRLKQTASRLFVALEPIYSQIAVPLLKLATWRDTRTSFGYCALYWILWYHGLLFSAFGLGLLCELLRRKLHPYPSLAELRAHRRTIDRSQAFGSLLAARLSAAPALGLHDVWGILGDYRRLRKVKKPKEDSGKNGSAGAGEEPMKGDDTSSVSLSTGDTADQQAEEDADLKRLGLFLLNEVADFLERLKNIFLWRQPTASAICGAVMLAWFILGLLPARYLARLVGLVVGGTFWHVIPVVAAIPESERRRIPSPLSFVPSDTEYAMELVSQRVARGLPVTAKQKKPGMQSLDSNVPEGEDGQGSSSSVDWKKVGERIASTKEMASDVKGLFREGQWKKAENWKALNPLAPKAVSSQNGDEPHIETRTFPATMKSHGPGLISLTPTSLFFTSLLSPQPVLTVELADITGVKKVTMTKGLEVRYSHQHEHGAMEEKDVSFQLVGARGELFARLVSSGGKKWAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEI5</accession>
    <name>A0A2G8SEI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEI5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="87" mass="10033" checksum="C08996B13F25ECC4" modified="2018-01-31" version="1">MAYFEPSDSMANKYQGDMITKSFLLTNVERIRSENITKSMSVFLHGWKLGKNSIPPPLIQDIYPKSPCWLGNKPHPMIHIKEVELDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEX3</accession>
    <name>A0A2G8SEX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEX3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="273" mass="30902" checksum="9EBC9C3E16668B48" modified="2018-01-31" version="1">MVQLVRRPAYHYHWTQHRNLIIRIAFTQDPEYNKQLLATIKQKYGFRRLYWMRHLNSHTLVFDANDEVEEAPRFKSIANSDMGKHPSSSLHTAHQRSPPCSSSSLSSPSSSSSSSSPPTSHSSSSSGRCPSTSVNAPARSTALTGTTTKAGATGTSPPILRRVVVNNYEDDDQDDDEDDIVDNDDNRTPRVPPPTPLLEVVDLPFEFMHAHKPLPYRMIDIYYFYDMAEHWTATYWSMYDVLNDSQDDYALLTPLTDGLDLNTVVPMSYDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFC0</accession>
    <name>A0A2G8SFC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFC0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFC0"/>
    <dbReference type="OrthoDB" id="2762851at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="24985" checksum="579449DABD301809" modified="2018-01-31" version="1">MEEPHHSKPATFVAFSAASLLFGVLSSQALVYFRHYPQDRLCLKIFGITRQVATILLLETAQLVLFAVMAWFIILGPGPSPQVFHLVSGAHFLIDGTIIGVVQGLSSYAFDVNSSNPDFLVAVDAITGVVDIVLALVFVVVLVPARTGSPRGNRVVKKLVISPDLYSFETDVDEEYAQVFLNVNAGVVNTLWAFVALGLLIAFPSSGIHALVYLTGTTSERFSSRSFPAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFM3</accession>
    <name>A0A2G8SFM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFM3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFM3"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="154" mass="17287" checksum="FF0ECC703AF86F98" modified="2018-01-31" version="1">MVEKNINDNHSGDVGTYAADLVNEIKLQTGTYKSKTSDWLSCTSTTEPVSKRFFLTKPPTLEDEVRRLLPSDDESVEELERRATVTPLECPLEWARESNAYCCSTVFTYTSGEDLCTSSYYTNAVPVIDLQLAKQGYRLAAWLNVIFDGDTNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG29</accession>
    <name>A0A2G8SG29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG29"/>
    <dbReference type="STRING" id="1077348.A0A2G8SG29"/>
    <dbReference type="OrthoDB" id="2801180at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="59247" checksum="AE0346354702341F" modified="2018-01-31" version="1">MPVDILIEVLTSLAPGRRESGAVISDDDPPTPAYRLENRNALAAYLDDLNPVLQFLPVYSRHRSQSPKTIDGAISTASWSRLQSYAIRVRGLTIPCDSSVHWHPSVWPFLAKSCAGAPLFPNLSELDALDLNTEDVAPIMLVLSPSLRDIRISFETEHSNRAVVPSIVGSVLHTLALTAPRLKILSLMGDHSLDGKHLQCLERFTSVQEIALSQSFHVDEAVLHSISKLSTLLILNVGIRLGGEGGERIQTLDFGDSFRQLNTLTLRGKSKDLSDVVIAISPPSLQWLNLEFTDSVSVTTLEAPLTAIASCIPDTVTSYGCHFNAALSPLPDALASLIPQLLLKMPNLEFFDLFSHKSPLSVTNEDLVRLGDAWPKLKHLNIRQWTYKFNQRNVRQPDVSGLAELAKRCPKLGMLCLPELDISKTIEPKVIPFLRHRLKYLLFQSVSTAPTQALHEAAVAIDVLFPRLDLHDMRPMAIGPGTQWMDVWRTLEIMRWGRRNYRLSDSGADSMVPKVSDISRGRAPGSHTQNGEVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGC4</accession>
    <name>A0A2G8SGC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_04919</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGC4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGC4"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="12">
        <location>
            <begin position="113"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="11">
        <location>
            <begin position="198"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="10">
        <location>
            <begin position="301"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL32802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="457" mass="49931" checksum="3E4E16C2C7F6C258" modified="2018-01-31" version="1">MLANTTWRMANLTRACRARALRGMSSAERTSRRMASGYAKFDWEDQLNLESLLTEEEIAVRLVRVKTYRLSMSLTSSTSRKTSCLESSMLSGQKVRLPFNHMSCSRPIAPPSEFNHDLLPAMGELGLLGPTIQGYGCAGVSSVAYGLIAREVERVDSGYRSTMSVQSSLVMHPIYVYGTKEQKEKYLPLLAKGKIIGCFGLTEPNHGSDPAGMETTATEVDGGYVLNGSKTWISNAPVADLFVVWARCKWDNKVRGFLIEKGTKGLSAPPIKHKLALRCSLTGSIFMDAVAVGRDALLPHGEGLGAPFGCLNSARFGIAWGTMGALEDCVQRTREYALERHQFKRPLASFQLVQKKLVDAQTEVSLGLLAALQVGRLKDEGKVAPEMISLVKRNNCGKALEHSRKVLDILGGNACSDEYHVGRHVANLQVVNTYEGTYDIHTLILGKALTGIQAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGD9</accession>
    <name>A0A2G8SGD9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_05352</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGD9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGD9"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="16">
        <location>
            <begin position="162"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL32648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="521" mass="53716" checksum="A4B0E7816908B9F3" modified="2018-01-31" version="1">MVVGLRPANITGLHSTLLDVSDPTSPNYGKHLSNDEARAFVAPAPETVQAVTGWLAQHNITANAASPSGDVLQMAVDVNTANALLNANYVASSHPDTGSTVYTTDSYSIPPELEEHLAFVYPTTNILPAIVSNPSVTKISLAKHSRRTRSKRAAIPSSCTTTITPQCLQAIYNIPATPATAPGNSIGVSGFANEVANQTDLQGFFQALRPDITNGSFNVQSIDGGTDTGSGTVEASLDIQYTTGVATNVNTTFVTVGSQNQDGVFGFLDIINSLLAEPDPPLVLTTSFGFDETFFQANPGIANTLCNAYAQLGARGTSVLFASGDGGVAGSRFSNTCNADGSFVPTFPSGCPFLTSVGSTQGNSPETAAQFSSGGFSNVFARPDYQSAAVESYLNTLGSTNAGLFNTSGRAYPDVSTQGVSFAVNIAGEFEAVSGTSASSPTFASVVALLNDQRLNAGKTPLGFLNPLLYSTAAAAFNDITSGSNPGCNTTGFPTETGWDPVTGLGTPDFNKLLSAVMAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHA7</accession>
    <name>A0A2G8SHA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHA7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHA7"/>
    <dbReference type="OrthoDB" id="2611509at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="182" mass="20390" checksum="EDFD9D7E4EB11763" modified="2018-01-31" version="1">METAELHLLLIETVTNERECVLQFDGERLALRSWLWPQERSGALIAPENLREYRSSHNFLGPGCFCPALSSMTTPGFVEAAILQRGNSGFVAMCSTDSCGYLVFLSRVFERANMPTATYRKRDVESIEPPRVYHLSEDQDNVFGKANVEDRKPSVGKYCEAPCPSFLQLAECCHAQLGTANY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHC8</accession>
    <name>A0A2G8SHC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHC8"/>
    <dbReference type="OrthoDB" id="2751071at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="619" mass="67945" checksum="0AFE81683E01FB17" modified="2018-01-31" version="1">MATSIDTPRFSDLASSLPITDRASLVGLSDHNVRVLSAAKADEYRKFALALLSIYNAVAPIHRLPFEVLSTIFEMCWMNRRSFCIGHVCRQWRCVLLDTPAFWASAVEGEPFRLQDPSNGYLQAMLERSIPQAITPLFRNFFQDMSPCLALHADRVVSLAVILGDHPELAELWSCLNAGMRSLKTLAISLFNDPWWALGTPTPDEILRLSPTTLPRLARVTAPGSFLKYFTIPSLRHITLQNAAVQHAYNHRLPSDEYLRNALAVCALNLESLALRNVSPPGGYEDAPLSLPTLHKLVIEDTARPCAVMLSRLVLPDTTHIQASIDGCTSLCAAVPPSAPAIQSALSATDTVAILGISNTNTIALHCCSGTTNFQTSLLTAALHAPEPRRALAPDDLVRFFRHKPGVANVVLGELDSRDVPAVDLRAFPALRRIVAGGSMAHHVLRELARTVTVRVTDSSESESESDDEIQTGELGGDPRPGDEVQVRAICPELDMLNLDFEFKLCVERREDGSVQVPQPAVTQMDSETRGAVVDAHFRALCAELERVLPLRAKTGAKPLRLELGCPDWRQWWLAGSEGGQMWAADLEANTAELELEPWGPIVERLEKLVDGPVMFNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHQ7</accession>
    <name>A0A2G8SHQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHQ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHQ7"/>
    <dbReference type="OrthoDB" id="2755983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="249" mass="28179" checksum="81E70938AC1B172A" modified="2018-01-31" version="1">MQRSHPDSTLSLSSLSPRTSLRLRQSMTGFRAVGDTLGPNYARREGELKGGTRQSMDATVASMSGIPGRKMRWTLKSYFKYVYLALRIKLVGWPTDIPFMNLSDITGLARISRIATLWESGRMYFAPVTDEEYLAALVDPLSCAPGPLHHGFAPDLGRCDIKKRKYRPKTDPLNLRKGRYIRNGPKSARWVSQMTERRAEGRELSVDPIASFSDHGGPSNRPGRRARTRRQEDSEIRGVELEEDPIENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHU1</accession>
    <name>A0A2G8SHU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHU1"/>
    <dbReference type="OrthoDB" id="2749703at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="15765" checksum="9705E5D4647A8DAC" modified="2018-01-31" version="1">MASSSTPKSNPTSPKSSPRSKLNATPKHDWVPDPEFYYELHTFQVDSVRFRIPTHHLAESPFFQKLFHVAAPSGPVETFCDVDHLEGVSRPMLCWSSVASWRGAGVWLRRVSLCAVDYGSLRECRGTCMECSGACMECSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI43</accession>
    <name>A0A2G8SI43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 76 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI43"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI43"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013909944" description="Glycoside hydrolase family 76 protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41627" checksum="6B8386F3E3E61691" modified="2018-01-31" version="1">MLFNFGKLVSMTTLVTVLSTLSTYPTSTTAAPRSLVPRGQCAATLSTASSVATRLNSAYWNGGGWGIFWTDANTIEDFYNLMLAEGSTDLDVADSTTIGKLALEQNRNAWISQLNGSNDDAGWVVLALLKVSDYRNAHGQDASVYVNSAKIVYDLIAAEWDTSVCGGGVWWSSAHTYKNAITNELFLHTSANLYNRFGDATYLANAQKTWTWLLNSGMRNSQGLWNDGLTSSCQNNGQTTWTYNQGVVASGLAELYLATGDSSLLTQAEITLDAAISLKTQNGILKESCDNADPTSTCDNDQAMFKGLWMKHLQFYLDRATDRVSKYTDFIGAQESAVYHYATGSDWTVGNVWYAPNNGGSLFTAETQTSGLAAHVCAAKYGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI89</accession>
    <name>A0A2G8SI89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_04093</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SI89"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MI" evidence="9">
        <location>
            <begin position="1426"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="795"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="853"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1244"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1345"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="162"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="226"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="496"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="907"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1275"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1318"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1397"/>
            <end position="1406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1558" mass="166175" checksum="7EC163F1890F2FEA" modified="2018-01-31" version="1">MSKSSTASAPKTSTQLPSKSAWAKGPPANTSTAPSPRPQSPAPSAAPSAPLTHSRRPSTLGQGVAFKDGVGARTSSNASKSGAHPSSPAQPGPSSLSLSLTLGRSAPSPGSSVTFGSIDDASAPISSSPAPAPMMKPDGIKSFGSLPANPNGKIHSRTTSFSTGMPPSAAAAAPVSSSSSTATSTSSASTSSSTSTAASTAPSVSGSSSTPRAAKFDVKSLFQNKSSDAPSSTTAATASPSHRPTPLPQSSLSPQGQPPHQASPSQMGAPYNTFRPQPNGVPMTSPGVPRSPSFARQMPNGNVNGRPPAPPGGPPSGALPAAMPSPRMGPPPHGGQPQPVPHAQPGVPVPAPQWGYYQYYPGMPIDPNYNPYQTAQWMPQHLPQQHPPQGPPGPPIPGLPMSPRGQPPPLHAPGTPTMAPAMPPNAHPPHSTPSPHTHTSNLSNVSSTPPTPASTTAPGGGLSRLNSNANTFTPKRVTIKSESGQEVDLERWKKQAPAAVASPVVPSSPARRTVQVRLETEEAKKKRLAEEEAEKAKKEAEKAKKEAEEKAKKDAEEKAKREAEEKVKREEEERKRKEDEEKQRVRKEEEEKERKRKEAEEAERLRKEAEEKARKEAEERAAREAEEKAKAEAEAEAAAAAAAAAAAQEAKAEPEEGEVQEPEQAAEATDEATKEEAKDKVSDKAPLRIDTTLSVDGKRRPGRLDLSGTKSQTIPAALPSALATARIIEDIGSIQYPEGVKSPKPELNVNAKQGKFRYDRDFLLQFMAVCKEKPDSLPPLDAIGLEPVEQTFPMTRGGSHGRRSSSNVMPPPSRQASVGLGISGFNKPSVNPFTMGQFSTPNQKLTSDDRFAASNRSTSMSGGPAGIPFGRPSPMVRSSSQGGPGGHPSSGRTRSQRGGKRDKERPSAAPSGPGSSFGPSSALAGVQNLEPVVPLEVSANRWTPASLVKKSQPVDSESPDVVDRKVRSLLNKLTMERFDSISDQIILWANRSEKEKDGRTLIQVIRLVFEKATDEATWSEMYARLCRKMMEQISPNVHDDGIKNADGKPIAGGQLFRKYLLNRCQEDFERGWVAKEATAAAAATKASEDQAAKAAAEQNKDEESALYSEEYYAAQKAKRQGLGLIKFIGELFKLQMLTERIMHECVKKLLGNVENPEEEEIESLCKLLTTVGQILDTQKARAHMDVYFSRMKELTKSGNVNSRMQFMLQDVIELRERKWIPRNQMAAPTTIAAIHEQVRCEGETRAGEGSLHPPDQYVPGGSRRGGERGEHAQVGPDGWAVAGGAAARPPPKAGDLSKFGKIDKSAPMTFGPSSVFQKGDKSKNRESVGRQGSANMFAMLSGNPEVASEVAGKSSRPPSRKSSIDLGPGGVPEGAVPPQRKRLQLLPRSVPLEAKSESTPAASTVGSEDEAEEDQPSGTPSLSEADAKTRIDEDSKEFFSVRDLAEAEVYFTKLPSEHRHLLVDKLVTKAVESKQADAQLVADLFERAISRNLCSPASFEEGFTPTAEIIDDIAIDAPKAMDLFALMIKGSHLHLDEERRTRLASKSMDSDKLVALLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIA9</accession>
    <name>A0A2G8SIA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_04748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIA9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIA9"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="6">
        <location>
            <begin position="427"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="875" mass="96079" checksum="E04F79327DF28707" modified="2018-01-31" version="1">MPPSDFAKASISEVVEQLTTDEAILLTAGVGFWHTHAVPRLGIPAVKVTDGPNGAYMPFAHASNVIHTVYEFLTSTGARGNYFFMSTPAKCLPCATAMAATFDTALIETMAKDLLAEEVKLKAASILLGPTCNTQRNPLGGRSFESYSEDPHLSGMVAAAYVKGLQAGGIGACIKHFVANDKENDRFGYDSVLTERALREIYLMPFMLAEKYNRVNGTHASENPHLLQDILRKEWGTKALIMSDWFGIYSIDHAVNAGLDLEMPGTNKWRTLDLMNRSIQSRKITARAVKERATKVLELVQKCARGAPEVLDGVRVEQTGDRQSGRELMTKVANQSIVLLKNEGNILPLKPKEQGLKKIAIVGGNAKATVLSGGGSAALKPSFFVSPYEGIVAALSKIDENVEITYSEGSRSWMQMPTLENDIVTEDGKPGWIGSFHSHESDESMTPLEKPTTVRHIDETRIFLSVDFPKELTKRYTLRLRGFFKPRDKDTDFEFGLLSAGRAKLYIDGKLLIDNWTKQKRGDAFFNSGSAEEYGVFNLKAGVKHEIFVDFINVRAPADEDPIETLMDTNAGVRLGGAEVAHPDDLMASAVRLAEEADAVIAVVGLNADWETEGYDRTTLALPGRTDELVRKVAAANKRTIVVTQSGSSITMPWADEVPAIVHGWYLGNTTGDAIGQVLTGEINPSGRLSLSFPKRLEDVASHGHFHHEHGKVWYSEDLFVGYKHHHHRAIAPQWHFGHGLSYTTFEYSDLSVSEPKVENGDIAIKVSVKVTNTGSVAGTEVVQAYISHPTTSEVTHPPLALKAFGKVFDLAPGKSETVTLSLDKYAVSFWEERIARWVVEDGVYRVRVGRSSAPEALTLSGEFKVAKRFEWNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJK1</accession>
    <name>A0A2G8SJK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJK1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJK1"/>
    <dbReference type="OrthoDB" id="2930792at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="31508" checksum="0D9F1B41D7850A06" modified="2018-01-31" version="1">MLIQYSPNPHCYAILRIDHLATVEHFPYPDIIDAAKKMQPKTYLVYLRNALSIPFPQDPWFPFIVVPVAPLQPPADGHFTPEMCIPIYPNASHPAGREPVHTELPFPYDNCYHWSNARGFNVRVRPRKNGYFDEDVAVRPRIRDEGELWRMVAADRTKVEEADAPDRPMETPLPATPVSIGPKPDTQEDCSSIQGGELGLAQDEPLENDLGEVDGQSCASDEVISEFQAIVGMGVFGTRLDNKDDYPLVDVWLELADHLKQEDIPDPRNFYAECDTLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJK8</accession>
    <name>A0A2G8SJK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJK8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="228" mass="25628" checksum="A56E93EE2DEE73BA" modified="2018-01-31" version="1">MPSRTRRRPRPLPSKSSVLSAIPPHVRVVVGRPRHKKPPPYARPGLTPLRHSVTAEGLRAAAESGGVGEPRYSNPYNNEECHYHYLFPPKSPYASWNPRLSSDFWGQARQDVVNDGAIYHYLFPPGSPYESWNPKCNNRMLCGQERTVFDLSRHRRRSCAAPAQYWYVYPCLLPRAALLITALHYQSKLSSMIALAREDTARANAVPTSETSSGTLKRTSSHAHATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJM6</accession>
    <name>A0A2G8SJM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_03683</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJM6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJM6"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="9"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL33975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="506" mass="53405" checksum="76C8555C12E9265B" modified="2018-01-31" version="1">MKFSHRKGFIDRESYVAQYLALALFTIGVTRTLGSDDLLAAFAAGSAISWDGHFNTQTEDEVFSSVIDLVLNCGCFIYIGAWMPFNMFNAPELYLTPWRLVIVFVAVIFLRRIPPLLLLYPWVPEIASWKEALFSGHFVKLECGLMGVGAIFISTLAVTELPTPQSPPQGQAQALAATLQTIVSFVVLGSIIIHGLSIPFFSFGRNVHSRTLSLSRTWTSRTTNAPDWLLWARSTPGEVTRPASPARDEEGRDVEQGMQEVDPTNMAESVVKSQEGVNVSANRDKDRGKDRHVPELGVAAMISDATAKYPDDENHSRYEASEAEAASTHAKSMEKADQPLSGSNDDDPAGRPLPLASGAQTPASDSGGVYTPTRSANPSGTQTPVSPGPGPRTVRFPPADELATYLATHRAGSQQPPAASVRAVRFPEDVTAAAGPGEDAASPPASTSASVSVAAAASLLARGPGAPDVVGGAGSGATTGSGNENEGEKEKEMGGVGRDASVVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK43</accession>
    <name>A0A2G8SK43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_03843</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK43"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK43"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="9"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL34132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="322" mass="35143" checksum="196238E307E6807F" modified="2018-01-31" version="1">MSGDDDSSGWQLTESDPGVFTELLKTLGVPLVVDDLYSLDAAVLSEFQPLHALIFLFKWVSTGSAEPSIGGQYDPDFPGFFAHQVVNNACATLAVMNAIANIPGLQMGPQLSDLFAFTVGMDPQTSGMAITSSDWLREAHNALSPPSAISLDGLDLPKTSEDAYHFIVYIPYAGSLYELDGLKQNPVRHGSYSEAGEGWVAKAREVIEARIGTYPPGSIEFSLLAVHEDPLPRLREQLAQVQSAGRHVDANELIVKIATEDSKRERWAFENSLRRHNYLGFIHALLLGMAKAGTLDAAKEGAKKALQERIEKRKKGEAMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKP6</accession>
    <name>A0A2G8SKP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKP6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKP6"/>
    <dbReference type="OrthoDB" id="3257007at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1090" mass="117345" checksum="9D2A36FBA3D19AE7" modified="2018-01-31" version="1">MDTPGPPTATATGPESSPPERKAGKKRQIEPDDSSVGNEGDMPSTSVEGRVMRALPARSAPLLAVEEVSSAPSPSASEDVFNQESIASFLDEFTARNKKRRFKEPDMVMFIESLIALLQANPSNMTLATQIEKLLIDNGFFDPQESGSDSGSDDAMEDIDEDAVEAALFVDDTNSTDDLQGQDAGGREVIINPLRDMPEDIESGPSESPQQSSLLAIPASVTSTLDPQEEEESILGPQSSLTIAPRPNSPDKDANMDGSGATDDPREGVRSPQVVDNPAVPAASSMEDPRVPAFAATQPRPTDANMDGSGATNCPPDGVAAPTPATQVAESDVASSSFVGQLPEYSLELRQIIDDPAVPAFAASQPGPTPTTTPRLNPEDIDANMEANGPCEDVQLQQVVNNPAVPAFASAMEDPRVPAFAASQPGPLTSAIPRSNSADTDTIMASDRDGPQDGVVPPPPPADQDAEAAVSRVKDWAEGGDATWPLVVGKDQCNAIINWASERKAQAGGPSKRTDKSTNCFSFSEFAPRGCPQSVSATTGSSAIFGTSMNFSFSPMTTTHSTAASTSTMPVTREIAGPGVEGSVLPVNTPSTSNAPPPTILLQGSSPETSHPPHGHVASSSQSNQIVEDMFESTPIDVDGPLTTEPEDPRLSSDLHLDQSEIMSGIVDSSEHPSPSTSRALEKRPAGLEMPPLLTAPVPPSQPFGTEETSSMWHGTIAGTQRVEPLTRSDFVDFMAGISGEIRTFTNTVTEVLQARDGRAHNRGDNIRGSGHGPTGNADIPEEDGDADDESDIAEVCNVKKKRLTRHRNSKQVQLTNDVTKHALSLLRRDNKKAPFPADTVASAVAVGGFRPEEAECCSAESFCLDFANTPASNWNTSATKVFVRDFLSVGQYECRNSAAIEKMFIRHFRTLKKHYLKQVEDQRAAANSRTVDRTPINKAHARYQRKYNMFQRRLRAALRYQETRRHVRLLQAVGPDGMSSDEEDDSSVVVKKYGVLKKAWRSDVLVKLLRILDALHRRHRKEGQGSRQGQLPRTRYLTDKGDDTRRPCAGLPRSAYNVTWLATLTPIQLEDLRIDEREHDMTCSHAIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKY2</accession>
    <name>A0A2G8SKY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKY2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="113" mass="12557" checksum="123882278BF0F1D0" modified="2018-01-31" version="1">MTCYNKATAFKLRRKVTLEISGHPPAFTSLRRHRAHCPTLQMTTATLRYFPPPDGAVRRLYRLPSRSPSTTLNLTPIPSCALVRQYASASASSPPRQTTAEQAIAHVRRGPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLV8</accession>
    <name>A0A2G8SLV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLV8"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18002" checksum="DBFA02C8EF67FE9E" modified="2018-01-31" version="1">MAIIIAPPLPIGPDFFDIPEIFNAPALPRPEPTIKLHKRGITVHSPLQPFTVYMTKRQPEGPVYVVKAIDPSRPEVAMYDLLDQHSSSPTDHTIPHELIRCERPLVVMPYASPIEKVCNYKTSSILATFDQILEGVEHMHRLRIAHMSPPQRGTLNAMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM13</accession>
    <name>A0A2G8SM13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM13"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="216" mass="24095" checksum="8AC9FF33FE26420F" modified="2018-01-31" version="1">MSLQPAPTLDRRSALLYLLREVDAIDPTFFNTTTGTEGPPKVLPWTFHGLELTVKKRTLSQANSPSNITYDINLGEMLQGSTKPLLAYVLRPKVDAEANRAAFKRCLEDLAANKTALMSQQNADFFKPSTAPGADDFRRQFADVELRVRKRTASSADPANVVYEIYLGRLLPSTTKPLLAYVLHPKGNAEANRDAFKRCLQELADKKAYFMSEKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMJ1</accession>
    <name>A0A2G8SMJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_02769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMJ1"/>
    <dbReference type="OrthoDB" id="2734679at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013621016" description="Transporter" evidence="7">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33857" checksum="6A0227B509930992" modified="2018-01-31" version="1">MFSVTLILTLLGAFTTLSFATPVKRTVSHGAVINRDFPDPGIMRNSDGVWYAYSTSSSSGLVPMSNSTDFQKWTTPTNVLASIGPWATGTVWAPDVRRITPGHYVMYYTARRKGGPSNDHCIGIATASYPAGPFNPHAHPLICDLAHGGVIDASGFEAPGGGLYVLWKVGGNSIGKPTPIKIQHVGADGYTLLGKSTTLITNDPVDGGVVEAPSMIYWDGWYYLFFSSNVYSTLKYDISYAVSRSVTGPFKKVHAPNAPFLVTGKFGTAGPGGATAINVENKYVNMAFHSDINGKNSSGGRAMWTVSNVCLGNGVAKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNB8</accession>
    <name>A0A2G8SNB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNB8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="265" mass="30410" checksum="988E8CF8FA7F9656" modified="2018-01-31" version="1">MTLVPDDEFADELCPRVLEMLVMDRHRQERERAGLAPYGAPITEMLGGDLSEAELEHEVLLLEDVLCRRDNVAATWIPVHAPNRYHDIFLLNVDPEPWRSIQRDHSIYSLLQYTLGCIYDSRARPDRGRMHPRRIPLTDNIIDMHRLAEDLDNHPDAPTNNSGLLCAQLFHGWWIIRDCDGNYHQLPEDSYDFRALILPLHPGQDNDRLETLWRLHTGYLGVWPPQGCGIQDFQAYCARFYELEGDAMDTGRDDPQEGGGANVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNP8</accession>
    <name>A0A2G8SNP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNP8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="272" mass="29899" checksum="B9C6C2D65F6E8658" modified="2018-01-31" version="1">MESLAYTILELQIRCLPWSHCVSHEDLLARKKGWTGERWTATAGDPTGYGYFLDAVRDRGQVLDYARWKRELCGDSTPIPSGPGGAETPFKYDPLDVDPPIHWRSAYDWDSEAHMPLTAAELVHTQNSFMGWSSVPGSAHGFNPRSTWSGPMAVEDAATFGDELELVLSGLALIDRRPTCRKTLHVWQEPEEEMRRFSDICGENVSSVVGGDWDNGNGDGRSGSDPVNGGYSDSEGESEGSGEYSVDVTEDSQEASGESSDSDDSSDFRARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNU6</accession>
    <name>A0A2G8SNU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNU6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNU6"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="508" mass="56204" checksum="56F283CA30D9C33F" modified="2018-01-31" version="1">MSIDTEVPLTPSTVTTRLQEDETEWEDIPEPHVAHGERNGSTTPRESSVRASTPASPRAITRRRKTGKTTSSLGQSQGALRRLPPPHPQLQPQLQPQLQPQPYVQPHAQPEIKNAWNMASVFELSNDQIREALAQIAAASVRYIGSVLTHAFQLLKKPLGFLLFLYLLAYLLSWVFSSFRSAFEPVCWVPGISRTAFCRPPRVSENATFKSPLRVDYPRLVEIQSASFEQLLDGGGIGGPALNLDIKKTEMATRDLITLVKHSELKSRALLGQSLYDFVLDAKKAGRGLAKLTAKINGAVDKVMAVNDYALHTIEAAQAQEASALVRVLWPFGGAPPSRAAALAAFQQSMDVQASELQRLILEAEVSAANLDALDAHLDTLHEICTREHLDLGAARDALLAELWTILGGNRDRVRVFNSNLELLRELGEYRKRAAAHVAAAAHTLQAMGEDMEDLRDRVAAPDLLGETVPMEVHMKSIKAGLERLRDHRIQAREREQMMMNRVFAIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP78</accession>
    <name>A0A2G8SP78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP78"/>
    <dbReference type="OrthoDB" id="3270129at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="16900" checksum="563C8A113D5AEA1F" modified="2018-01-31" version="1">MTLLTAGQVRPGLGPKGVTLSAHEDPGGKVKKFERQWVVDHRVKTAVQGSGGKFVISNPLAIRRGDFVDVAALVTVVVHRGRHASSTEVMLAPLEVVRLRTRKEVKIDGQALLRGPDPHDHRTSEADAVLGVVTGFEMGGTMFPDDIEDDKMDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPH0</accession>
    <name>A0A2G8SPH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPH0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPH0"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="56"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="14405" checksum="724388970AD2DF94" modified="2018-01-31" version="1">MISQLAARSAFCNRTIPPKFASACRQRTRPVSSAVKPIELHYDKVIPPDGNATDRPLVILHGLFGTKRNFGSLSKAFAKDLGRPVYTLDLRNHGTSPHAEPHSYPAMATDVLRFFKMHHLSNVSLLGHSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ49</accession>
    <name>A0A2G8SQ49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ49"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ49"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="2">
        <location>
            <begin position="163"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="175"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="300" mass="33935" checksum="8C98D227E73C09BB" modified="2018-01-31" version="1">MKILKTLPRNHPQPRQRTVSSLVVDSRKGGTVKIAVDCRAGEYKWQHWECQNCGSALQVVGKSRSPNEFWNQQNPGFMHHKIADDSGIQVSHLLSYRSETDSGHYHIYLLPQNRGRIYLILGSPRINGLANQIFQEYQEQAVSGELQFRRWPLRSHQCRGELLTNYFSQNTGEPYQYVGGTANTIPFDGAPSAVVKARNLIQSRMMSVMQAESQPYHFNEVLSAAYMEEQRMAFHSDAENGLGPRVASLSLGSAALMHFRPLKKYRKDSGGGQKCNALTLFLKHGDVLIMDGAEVQEYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQF3</accession>
    <name>A0A2G8SQF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQF3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQF3"/>
    <dbReference type="OrthoDB" id="2732257at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="392" mass="45557" checksum="5EF705CCF2328EB0" modified="2018-01-31" version="1">MSSSLEAKAAAKPHPLSTAALKFGLSPDEFFWRDHQTWLADSGYMLRSRYRLDWEPSWLKSKKDPFECEDAHSLLASKARFECLNVTNVSKQIVIMDAIRISDGRVVALKRVPKSTYPFEEELNRFLTISEPQAGDPHNHSVPVYDILQSPLDEDIVLLVMPYLIRIDELKFSTIGEAVECFRQLFEGLQFLHRHHIAHLDIHRNNIMMDPTPVFSYIPHPTHSYKSYDFKHSISTRTRTSHPTKYFYIDFGFSWRLPPDDPFPRVGLDVGADKSVPEYEDRQGRHDPFKVDIYCLGNTIRQYFMDKSYSLEFLRPIITEMVQQDPVKRPSIDKAFEQFEQLRASVSPWTLRSRMVYQDELPLGRLYRGCRHAVRTAFWMATGKPALPNPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR55</accession>
    <name>A0A2G8SR55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR55"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR55"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="493" mass="54782" checksum="AE4EA75FB3824595" modified="2018-01-31" version="1">MASLQVIDGLHNYELKECSASEATSSVFRAICKRGRMRNRLVVVKKFPIPCKHQNDTSHGVQDVVSAASLHSTLCHPTIVTLLSSFSAPTGFYQVLEFCENGSLSDFLHARDSHTLTDEELRGVARTLVDALVYLKKEHVLHRDIKPSNVFLTGDFRLKLSGFGLAIRLPRSDSTETALCGSPNYVSPEMLLGLPYRFPTDLWSVGGVLLTCLAGQPAFHAPTSGEVFENICCARYMLPDVSYEVQDLIAGMLQKVEIYDAPHLSTPCCLAEPVATYVSRVLPTKYAKQYEDAMQIVDRLNARIPKLIHFADDAKCILMSNGPPGDVEIHVPVEDAQFDEGEAIRLRLQRSRHTLEISRHLRKTGCTRRDGGEWTKKVIPLSHALELPENEDRSLDGLERLAMTRLRDFMRVCDAAEAVLGARGPHTVDKHDGTGRERLERALRHMEGTSNDKDLGERSGARPPSEDRSRASGGSFMVVPPRPRKFSSAVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR59</accession>
    <name>A0A2G8SR59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR59"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR59"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RZ-type" evidence="7">
        <location>
            <begin position="508"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="593" mass="66318" checksum="B0A62929B1D65ACB" modified="2018-01-31" version="1">MLIVGTTVLYLARLARNRVLGVARILRVLFHVERYVPVFRATNVVSKFSAVVIAVRLTCLLCASDEVKSSIVDLVMQRTLADLDHESESLDELTITIPSCRHVFTVETLDGHCELVQYYHRDGPNGKWLGLEAPPPGFRQPPTCPTCRSAITTPRYGRVFKRADLDILENNVAFHMSKSLKAVQAKMDAISNTTMDRTVKELAAEIKTAPLKISTKELKGLHRDQGVLLKSARSIPLILQHIDPLNNRLHGLPADEAKALKKVILALFTAYKDAALTSQTRSAHSHAWEASFAYLYQKEMDDIVANPVNAPRNPQEYAMRVARMKVGQPPPRADKRFLVEAFWTTINIRLSIAAFAGTWVDAVTSRTKYPPGNRRVWASYVVFVLRSCAADAEVALQITRESESFRQEASTVLLLMRIELEQFRFNVQMSKQTTAKMTAVGRAKLADTAKEKRVSAEQRIATVRARGEGRQGAKNWLHSDFVEPTFAILDDWKALERSLRNDTFYEPVSLEELTQIVKGLNFSHTGHFYKCPNGHIFVITECGGATQTSFCRDCGEPIGGTGHSLLSTNSRATELEDIARAQGSHRSPWSWGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR67</accession>
    <name>A0A2G8SR67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">W2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BZW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR67"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR67"/>
    <dbReference type="OrthoDB" id="1727522at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11560">
        <property type="entry name" value="W2_eIF5C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051245">
        <property type="entry name" value="eIF5-mimic_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057397">
        <property type="entry name" value="HEAT_5MP1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043510">
        <property type="entry name" value="W2_5MP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208">
        <property type="entry name" value="BASIC LEUCINE ZIPPER AND W2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14208:SF2">
        <property type="entry name" value="PROTEIN KRASAVIETZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25504">
        <property type="entry name" value="HEAT_5MP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="2">
        <location>
            <begin position="254"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="422" mass="47583" checksum="8C5E1EF7E5BA99A3" modified="2018-01-31" version="1">MSQQSAAAKPSLQGVRIKARKRAVKAQAKHEPDIFRDQFLKYLENVPPTDFDAIANKLVQAGSTLEFLKYADALFEILLVGGLLQPGGQYVDDGAPLSPFSILNAKEPVEVADVKQYVEVFNKLIRRYKYLQRPLEENSLPNLLQYMNRWPAAQREKLSVATGLLFAQGLASASCLQSLTKDHLVKNDLSADIITLIFRAYLSSQSMEHLAGTLKRGSIKDLLLFFPPNKRDDKALDEHFRKAGLPQIAEWWTKRQYASLKDGIIKQLQGQLANGDAHADIVTAIKARQEEQPLPEAELVSCIWQGLISSIDWSARQDQNEALALREINAFTDILEPFCNGAKTEVALINTVQVYCYEDTRIIKAFPQVLKVLYNKDCITDQAIIYWHSKGSKPQGRQHFLQAAQPLVKFLQEQESDDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRX0</accession>
    <name>A0A2G8SRX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRX0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="84" mass="8859" checksum="B4608C3430028E56" modified="2018-01-31" version="1">MTRLAEEAGRDTTNRNDQTQPLLVDAAALASLSGQETNGADANAKVSYSGNWAGAVISEKKVCQCAALVSAIHADSELIYYRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSM5</accession>
    <name>A0A2G8SSM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00421</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSM5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSM5"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="61"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="497" mass="54739" checksum="AC4CB9079FB6C92D" modified="2018-01-31" version="1">MFSRSETNTLHDAADIEKAGQAPVQPKSELQEEIDDRNPYLCTLNPEDDPKNLPLWRKWAAVLTISSASLCATCTSSMAAFTETGLVQDLHTSHEVAILSVSLYVIGLGIGPLFVGPLSELYGRNIIYRTSYVLFFAFTWPTAFPPDIATYLVFRFITGLCGAAFLSVAGGSVSDLFDNQNVATPMAVYTISPFIGPIVGPLIAGFIVQNADWRWCYRTLLIWQFVQTCFLFLTVPETYVPVILKRKAKKLRKTDNPKWRAPIEQQSHNLARMILYSIYTPFRLLLLDRMALALDIWSALLLGILYLAFQAFPIIFMDVHGFNVQDTGLSFLGIGLGMFISLATQPLWNRLFRETAKQHGGHLPPETRLLMGQVGAVLAPLGLFIMAFTTYKQVHWIGPIIGSIPFGSGTIFIYTAVFTYLVTAYRPIAASAMAANSAVRSSFAAGFPLFAGQMYHKLGTVGATALLAGLMTAMAPLPFVLYRIGARLRASSQFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU01</accession>
    <name>A0A2G8SU01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU01"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU01"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="249" mass="27877" checksum="07A3B9B6073D519E" modified="2018-01-31" version="1">MESTGEVPPAVTDEKTVLQMYHVARNGEAIEIVPMRYRDLLKGAESLRKAFLNDPLMRYFVTADTAPFQGTRSKAINIVDWVGAMRQHRMVTIGGGLSLMKYGPPGNQNNLAFIAYLMKTLKRLRPQECAKRWKEFGAKAQMLVVEAFGNKVGDMYEIQALCTDPDAQGRGYASALVEYVLKQGDADGHDVWLLATDAYGFYEHFGFTVIRSGMIAVDNPAWDGEPITLYIMHRPAVTLTPRLKERISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUS9</accession>
    <name>A0A2G8SUS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUS9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUS9"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="283" mass="30054" checksum="E52594A3ED1120BE" modified="2018-01-31" version="1">MSRPEPHGQDYDHPHFDHRAGGEHGLGAQDFPSHLRDYISRDGLRDPPPGSRDMGPQEYGSTTFYNSSYSSSPPPPPFTADRRPLASNAMSGAGFSSFVGPRMLTSPQGIGVGAGGNWNSKPASFSVAPNVGRPPGEGGGGVSSQVQQSVVVSPLALNQHHRPSPPRGLPELYTSPLLASTPPFPDRDNRDAFFNHRPRHSSRPVPSPSSSLPRNPSPSLLRTPPLLLPVQPSGGVSSSPGWTRNTPSRSVTSWVGTPSRSRSPALPPIPLPASRRTIPATAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLX8</accession>
    <name>A0A2G8RLX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLX8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLX8"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="189"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="267" mass="28189" checksum="2AAFE63929D86897" modified="2018-01-31" version="1">MTVEIATPARMTTTTAAALDATLNASTAEAEANHLVLDGMAKTELEAGTAGGSETVTGTAMGAETETGMEVMAEGATAAMTGGVTGSTTADKIETATTGVLDLLAARLPRVHARPSQSHAAEDKAKPNFGNSGLLAAATKTVQHGDGTKTVLKYHEPPEARKPTVGWRLYVFKGKEQVDLLHIQRQSAYLIGRDKAVVDIPIDHPSCSKQHAAIQYRQVQEKNEFGDVKSAIKPFIIDLESTNGTIVNDSPIPTSRYFELMLGDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMA8</accession>
    <name>A0A2G8RMA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RMA8"/>
    <dbReference type="OrthoDB" id="2591260at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1373"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1521"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1173"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1207"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1432"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1555"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1616" mass="176560" checksum="460244FAF3B208C0" modified="2018-01-31" version="1">MSLPTPPGTSHRDEKENRAPRFTHVSWSDTTELYSISGSPPRTTSARSSALKPRPSRSILKKTSHPILPPIHEDAVHKESTPEPEDPLVDLHYLDNPIARIIALDASLCDLIQAYTSLMARLKNCVTGNTDADASWPLFQPIRKNRKSFVEALVRDLQQVFVDPLEGVASTSAFEPLSSPLREPPSTTSLPSPRDSPKKTRKRGMSEEQVKRARDLCGLCHAVMRLLSVIFTVPSLYNLFDEEELGYIFTQVLAIPLAKELPTPNARKTCALAIWLIQIQRLPAEVLEPAKDRIAYALRRGIDGELGKEGKKGSVSDGLKAIHDLALYQPAIFVPAFVPVLGGIISNLLAPTLAMRGQACHALGGLAHAAAALPPSEAHTRMSTTVAACLMKSDVSPTTPSKSKVDASPSKDSLLVRTLRTTLQAPDPRHSAQGPVWAFSVIAHLIVLLGPTVYLHPELTRTITALFSLGMRHPKSSVRALGCLAWRTMTWAFFRAPHVKVTFDTETDGEDESATEDDVISERKKHDEMLCSNFKVLPSIVDMGAGLSTVGALLGQDVMDDTLVLAALRVLRTMSTKGGATCKDALDLTRHLLSAAALSGGSGRAEEIEWNPRGLLAPSFFSANPGLLTAEWNQLSAAVKPLIEECPKIEDVRTLTLDEISAEGMWVEFLAIWKDGLTVLRLSWGSEEVPGEIREIWFNLLKCHAAPLLDSEDQVGLADLATSARDVLLEILDNPSLDFTMPKEELGDKVPSSPVKRRGVQDNVKGTDHPLPESRWNYAVKLFLVRDLFTITRAVFPSDIFAELAEAVLRYLNANEKYLVGDVQCSDEVREQWACLCAEAAFACDTNVVHSFWNNSLRKARRHSNWDADVRVSVWQAFLDRWNAGDSSGSRSWECAVVLLSAPFVEPSCWDMATEDIDTWDLFLRTAIDAALDHGIDATTLVDQIAGVIATNHSPSTPSAVRVADLLLSNVEIGDARQVPTEVLEFANDTLNSAYPPAPRHKVMCMWFVRSLTRVIDACPQELCFSMLELLLDGLCAWIGDEFQVCTEEEYAADILPLYQTVLVSMQSLTPSSKVLDTLGPVLAAPFCGRKDKHTGAVDAFSEFWQATYADFPEPPSGYPESITMCLEAVAQAKIEEEEDAMKVEDMTVVHEDVQSPTLAVSPELATEHMVAEGEEAVESDEEGSVVIPSPNSLARRPASAIFSRGSSPVTPLVLVPTTPTSVPRHLASPHRPHKSAVKDQLSANPLDASPAVDASPSRVRTTPKRSPKKNKENQSPMPAIASIAERLAARSPLLLETILGKRSRSDDVEDMAGMDGKLSKRSRLEASPLTPSALSNMQVYTVTQDTSHTLQHAPFPAKSAAKFGFSKTCVPNEADEASDDTESETSPVDTTPTPLSRKRKGVFMDAVEVPSVGQVHARRRPSLESLKDASEADTEAESEPEPEPVEVPKPTVRRTRSATKLLGKEADFQRLETPKRRRMSRAAQLREEAAAMSSPLQALCDAPPFGSDDSIMVASPATAVFDLPPSDDDPPVGQVTPHRIVSPSLRRVKRMEFDSSSDPPSDDSNMSNSPSTDRVMRKAAWLRKSRHFSSPKPSPRNLRSRSRVASSSSVLGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN22</accession>
    <name>A0A2G8RN22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN22"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN22"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="534" mass="57405" checksum="71A1D1F736B621A6" modified="2018-01-31" version="1">MSIDLSLERISKLLNHLPVPYTRPTIHVAGTNGKGSVCALVSSILSAASPPLVVGRFNSPHLLSPLDGISVGGKPIDKDTFMQARGEVRRINDEKAFGASMFELYTCFALLIFERLKVDVVVLEVGMGGRLDATNVVPDECILVSALTSVDLDHQAILGSTIEAITREKAAIARPGKPFVIAPQVHPHVVDVAQSVVKSSGGESAIALTSTVSTVEWDTHLDGPISPTEGIRVPLFQPVHIFRPGRSDPIRALLPLQGEHQVDNLRSAMGIISALQTHPSCERPGLNFQQRLTPDSISRGIRATRWPGRLSYHTISVPPAVNDTSNTSTSQEPDTQILVLADGAHNPAAATAVGAYISSVLEKSGSGPLTLTYILALSHSPPKTPEQTLKPLLAVRDSLRLAGRREVRLGVALLPFTPPLNMPWIKFVPPADMRPVVQALLSSDADADAEADADVRVEVLESSSDFSGLETVVAPAHAEPPRTEHVEEALRWAAGRRREGEDAFVVLSGSLYLVADFYRLLEKLGQAREIWGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNS0</accession>
    <name>A0A2G8RNS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNS0"/>
    <dbReference type="OrthoDB" id="2755197at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="5"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="301" mass="33563" checksum="220522612837915C" modified="2018-01-31" version="1">MAILHDLPPELLHAIFAWMEHEPPPRTTFVACSVVSRLWRDIALPYLFSTLKARRRESFANVIPFLETHPHIAACVKRLWLQRTGVSAPKPEVDYETVSALLARLPALVNLSFHTVKFVGLRSLPLGPQFASELSATTIPSTNAHTVQGSNHDGPYRLDLVILYSCTVPDPTPLFRILSLCEMDTLRATLNELPGTNIAQVDPAALHRPLRVRWLRVAVQKRPARIAQRPPPLLEALRVALEPGSVRAFDVTCHNWDEVASAGALLRDVGRNLTTLRLSVFWGSAEGEPRSRRLTNRDGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP18</accession>
    <name>A0A2G8RP18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Argonaute</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP18"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP18"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="246"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="545"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="794" mass="87474" checksum="AC195E1C119B50EC" modified="2018-01-31" version="1">MSHRTASDSGLPDAGSGRGLGGISPEVTTIGPKRSAFGQSGRALTVLTNHFDIQIPKHEIYHYNVISPSDNPLPTRLNLEIIEQLQTKVAPELFTPRIVYDGQKNIFSPRQLPLLSKSQEFTITLNDPVTSGEGHDNALDSAKAYNVKLTHVATINPEMLARFLQAKQSGDNKVLTAITALNVVIRMEPAVKYPCKARSIFASLEMATIGGGIVLWRGYFQSVRPAIGRMLINVDISIAAMYKPGRVIDVALELLGMTQNGPIVLSPIHGLPERELIKLQRFLSGVRINVDIPGQPTTGRRPPRVIKKLTNAGASQLSFTTRDGETTTVAQYFEKMHNYRLQFPDIVCIEVGSGAIIPMECCTIPEGQIMRKQLPPEKMKAVLDFAVKKPGERLERIRAAVGDLNYGQSDCMRQFGMHVSPNADVVSLQARVLDPPTLMYGLESDQPTVTPRHGAWNMVDKKCYQPATIDRWVVVVYEREERFNRDAAQGMVKNILQQFTALGIVCNEEDPVVIWERPTNIAGSLQDAGTKVIEKHLNEGQGPDLMIVVLPESSADMYQSVKHFGDITRGIATQCLRSAKCIRANKQYFTNVCLKINAKLGGINAVAKPREIPALKPTDAWKPTIVMGAHGIGPAPGDDPQAKSFAALVGNVDSETAKYVADYRAKPSRKEIIDDLEAMATSYISLYKNYQKAVEKKSPDADPQRVILYRSGVSEGQFKNVLKLEVPQLKRALAANNLDAKLTIVIVKRAHHVRFFPQNSQDEDKSGNCPAGTVVDSDITHPTEFDFYLQSQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPJ3</accession>
    <name>A0A2G8RPJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Het-C-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPJ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPJ3"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013614219" description="Het-C-domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="88897" checksum="3AC197434A1D0321" modified="2018-01-31" version="1">MSSNVYLLLLVLCIVILCIPGEGVYAFGAGNIPSFAFLEGKAFRHGDIEDALGDVAKKAGGFALGALIGKGGSKFSGLDVKRVYFGNWLRDYSQAVDVAGLQKLQIQTIVNLCMVLGFMAHGYATHEFEVTEERLGVYLPTEHIDNPKGYPDNARQYHPKLRPPVDPRELEIDPRTGMKNYIANENGSWDTSKALVRRTLERCIQIGRQGRATNNKVDTYEAYRLLGQALHTLEDFPAHSNFCELALVMMGHHDVFTHVGDQCRIQAPGGKQVAPLVTGTFGSSDFIHSLLGEATDHISQASVSDLNSELDKARAKAGSDRGGNGPADTLRDLLFKLPGGDSGEMQREMDSVERIRAGPQQGGKRPEDMTPQELHSVLWQVLTFRDSVVKKIEKTIGIVAERIPGLGPFIEKLMDSISVFVFTTLEPFLKPIMKQATSGLQLASGEVINNQDQYEVFNDPRASDPTHSFLSKDHFNLILNETAGHLGKIILLHTANLVVKAWDDTSTNIHHVTEDILQCLFHPEFHDRNSQIQRQMLDYMHSWVQGLGGKQHEVFSRLTKQAVRNHENTRLGSSGAAAAPQQGTYAHNAGIQAQSQIGGYVHQIPGVSQAQNVFGQAQGLLGKLNGGPNLGVGRDGPDGGGPGGFPSGPAPPIAARPPSTGEAASYYGGSSTGHRPASPSYAPPSGPPPSGPRPGYNKGSSYLSPPGPPPPHGHGHGHGDYAPPSAPPPFQPPSHSGYSPSYGSPAPVSFPGADISAGGYPGQSTYPGQSTYPGQSTYPGQSTYPGQQGPPGAPLGFDMPNPDASAPYGQPHGHGHGHPRPPPGGSPFGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQI5</accession>
    <name>A0A2G8RQI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RQI5"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07735">
        <property type="entry name" value="class_II_PDE_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000396">
        <property type="entry name" value="Pdiesterase2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28283:SF1">
        <property type="entry name" value="3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02112">
        <property type="entry name" value="PDEase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00388">
        <property type="entry name" value="PDIESTERASE2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="10"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="132"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="313"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1613"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="779"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="925"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1260"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1702" mass="179356" checksum="7483959202E72805" modified="2018-01-31" version="1">MSKFTPTPAEVALINHIFAQADTQKIGVITGDAAVKIFSGSKLSPTVLAEIWNVADEDNNGVLTRKGVGIAVRLLGHAQRGEKVSDALVSKPGPLPTIEGLPPVAAPSSFSVAPAKSPPPPVSGLPPLTPQDKAKFLKLFLGCHPNNGLLSGEKARDVFVKSKLPVDKLSQIWSLADTKNRGSLDATDFTIAMYLIQASMSGQLQTIPSTLPPFLYDQAQNGIIPQATGDSGHTSPSLTGSFSGRTVQPQYTGQTLSQIQSQMTGQTLSSIQPQTTGPLRPAPPLPARSVISTGSPFIQQQATGAQWDVTPQEKAGSDRLFESLDPQKRGFIEGDVAVPFMLQSKLPEEALAQVWDLADLNNDGRLTQDGFAVAMHLIQGRLSGKEIPSVIPTSLIPPSMRGSVGAGAAQPAVPEAIKDLLWDDSPPPSATVPAQPSILQPQSTGSILQAQSTGSMLQMQSTGTLSNRPTPTMSPPPPRAPPPVISDPFGGSPFGAGAVVSAPHRDLLGDDDEPHATSAQLHDQSAEIGNVKNQLGSTTRSLETAKTERASLERQLTEQAALLSSLQTQLSSAKAAYDTETKLLSALKERYATQAADIQKTREELIRAESDLSATKVEKAEIEGSLMREREEVRDLQRKMAETGTLIEGTKAELEKLRKEAKQQKGLLAIAKKQLATREAEKAKADKELEEATAELQGITSQREAAEAELEKETPAALTNGHSSVTATPDLAFAAAQPLPVSKPTSPDISPPTTKSTNPFERLAMSSSSRPESPFLPFVATSSLPAPTTSSVAQEQLAEEDPFGFNQPSEAPAEPSQIEIHEPGTPKQSVPPPITIGTPTSLDILSPAETDLFTTPPTTATVPEHTPSPSANEEPSASARFPAVDELPTSDSVPIPADLSASTVDDKPLEHEGDTDLTHELKEIEESESDSSSDDEDNEPLTTVKAKLAETTETKINGIASTSTTTSAFDDSFGIPATNEQTTQALSTATSVSAASGANDFESIFDTAATSKEAPASTPLPETATPKANGAATPGVNEFDQALGKLTTADSASEPQFPGGFGGFDSAFDDNFDFAAATAAQPTTTVPVANAAFPPAPTAAPAPTRGTSFDDVFGTGALPTAASAPAPAPAVPTFPPITAAMPAQPSKTLSFDDAFGAAPQPAQDLGASTSSQTNGTGSGFSFEDAFGGNDEALTLDSSFSTVSSLPPAAAQQPPVKAAQQPFLAQQQPFPTSSPLASPRGSSSTQPGERRSSSPSVRHTSPPPRHASPPPRHSSPRPRPTTADSKEKAVATRHNRLSIRLPFGRKKKEKDAPPVPALAQQQIVEDPTPAVDDDVEAVKTLCGMGFSRTQAVAALEEHGYLFKTGDAKWEDGVVALEGGSGLGAISRLLEARPNLFTSEHSGDSGAEVSLTTAAEVYSRIQCYLVTHAHLDHVNGLVLSAGSGQGPPKPVFGAKETLESVSTIFAGEVWPKLASWADAEEPGSCLLFSPLPLDEVYSPVARDISVRMMPISHGQRAPGHTYPCTAYFIRHDSSFQEFLFFGDVEPDSVSLDPRNQEIWRAAAPKIPDALSAIFIECSYPSGRADGVLYGHLSPEHLTQELCALAVEVVSSRQRARLQEGSSSGGGARKKKRRNTESMPDLRDSLTGLRVYIIHCKDDLLGTFEEPIHKVIAGQVRELIDAKGLGAEIVAVEQGMQIRTPASIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQL0</accession>
    <name>A0A2G8RQL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQL0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQL0"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="118" mass="13686" checksum="D89647E2390B6305" modified="2018-01-31" version="1">MRSKFKDEHPFDKRKAEAERIRQKYPDRIPVICEKADKTDIPTIDKKKYLVPSDLTVGQFVYVIRKRIKLAPEKAIFIFVDEVLPPTAALMSAIYEEHKDEDGFLYVSYSGENTFGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQZ0</accession>
    <name>A0A2G8RQZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQZ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQZ0"/>
    <dbReference type="OrthoDB" id="110024at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="358" mass="40137" checksum="3919EF7762F461BE" modified="2018-01-31" version="1">MDDSDPISQFFPDQDVDLYDVLGVKQDSNPDDIKKAYRKLALKYHPDKHAGASEDARADASLKFQQLGFAYAVLSDEKRRGRYDLTGKTDECADFGPGEDGWEAYFEQLFEEVTKDKLDIMKKEYQGSDKELEDLKQAYIETDGSIADFMTHIPHSTFDDEARFIVAISDLIERGDLPSLPQWQSSTKDEKAKLVRKKQAVKEAAEAEELAKELGVHDEFFGSGKKGARKGKGRGKAKADEEDTSALQALILKKRRNAESLFDNIAAKYAQAEPADKGSKKVKKRAKATEEDEDEDELDAFPKKRSRKDMPPPPDIDDTEFEKIQERLMENKAKRAAEGSGRTKGATKGRAGKGRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR03</accession>
    <name>A0A2G8RR03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR03"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="609" mass="65485" checksum="876582B597D2F2CF" modified="2018-01-31" version="1">MSTIPSRRKGKGRANADNAPSEALLNAREFITILRESEPSDDVQKERHVAWMEDFSIALISSQSQSPLSTASEAGEEPAAIEQIADEVYMAHALQLADLHHDWPDWASPIITDAHARAKAQAVAQQQALSAERERDQREKEERLAAFLAQKKAERARAKTAATAANLDSAGPSTARTTLPATTNAPTAPTKKGSKKGRSRKVKKTGEARAATGVAPATANDEEPQPKPKEDFGPKLAYVTNPARMYKYGFCQPLVDFQRCNGCAVAHKGCYHGDDAYATWYKELPVDETERANCDFEPPPQTRGRKATRGRSKTRPEGAGRATVQVASTSVPRAPLINFEPHFPTAPSAPIVSGSGTAPMGRGYAPGLLQGETINRITEYIRPGPLGFSHPSYEISTDDLRVQGVPEAGRREVRAVRSEIGDVRARITVLQGILRGLEQYEGDLVEELLEEAFNAENPASPSASSSANEEIAAAAPAVESQAGGEPIEDPANDNGPIAETADLVDTAAVEANASSEPSSESEVDEGSSSEESDEQGDADPSQQNSSANDTSDANAPSPVTDDVDMDAPGEPVETPTKRKRKRKENRAKAKDESREPKRRKDNPDLSEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRE5</accession>
    <name>A0A2G8RRE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_13812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRE5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRE5"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL24061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="698" mass="79359" checksum="399DD47EFE2BF5CC" modified="2018-01-31" version="1">MASESFGFQAEISQLLDLIINTFYSNKEIFLREIISNASDALDKLRYASLTDPSVLDSGKDLIIKIIPDKENKILSIIDTGVGMTKADLVNNLGTIAKSGTKGFMEALQSGADISMIGQFGVGFYSGYLVAERVQVISKHNDDEQYIWESAAGGTFTITPDTTNPPLGRGSEIRLYLKEDQTEYLEEKRIKEIVKKHSEFISYPIQLFVTKEVEKEVEDDEEVEEEKEESKIEEVEDEDKPKEKKTKKIKEKETKAEELNKTKPIWTRNPSEITTEEYGAFYKSLTNDWEDHLAVKHFSVEGQLEFKAILFVPKRAPFDLFESKKKRNNIKLYVRRVFIMDDCEDLIPEYLNFIKGIVDSEDLPLNISRETLQQNKILKVIRKNLVKKCMDLFSEIAEDKDNFNKFYEAFGKNIKLGIHEDAQNRTKLAEFLRFYSTKSSEELTSLKDYITRMPEVQKNIYYLTGESLSAVKDSPFLEVLKKKGFEVLLLVDPIDEYAITQLKEFESHKLVCVSKEGLELEETDEEKAAREAEAKQFEDLCKAVKDALGDKVEKVVVSNRISDSPCVLVTGQFGWSSNMERIMKAQALRDSSMSSYMASKKTLELNPHNPIVKELKRKVAEDKADKSVRDLTFLLFETSLLTSGFSLDDPTSFAKRIHRMIALGLDVDEEEEEAAVPSTSTETPAAEAASSSAMEEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRU1</accession>
    <name>A0A2G8RRU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSI_13989</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRU1"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013849630" description="triacylglycerol lipase" evidence="19">
        <location>
            <begin position="24"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="20">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PIL24236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="431" mass="47622" checksum="178545C188671CB9" modified="2018-01-31" version="1">MRVLAPPTSLLLSSLSFTPFTTATPIHTPISFELQDEYVPRLQDAQLHDPNQVVFDVSDARNQQSSATVTLQAIPTTVYRPRDSAAFQHARLRSLRSQESEPIEWEEVQLLAPDIEDKHTLSQLARMTGNAYALPGRPNWYEVDPAWNTSFPFGWEDKADGFRGHVFLSPDNSTVVLSIKGTTLQGPTSKKDKFNDNLLFSCCCARVDITWVFRQVCHCYSGNWRCDNTCLTDALVQDSLFYNVGVGLVNNLTALYPEASLWLVGHSLGGSLASLLGTTFGLPAVAFEAPGERLAAQRLHLLLPPFPPNVTSPSIPAYGLPPVTHVYHNADPIPQGTCSGVGSPCAQAGYALETRCHLGKSIVYDAVDKLGWRVDLRKHVIKEVITHVIEAEPEGGWEDGRDVPVARVEEDCLECFKWEFGDFKDGDPDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRY8</accession>
    <name>A0A2G8RRY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_13850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRY8"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="631"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL24098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="704" mass="78955" checksum="D6360E0FDBCB97B1" modified="2018-01-31" version="1">MKGFKMKVSQLGRKNSADSTSSKSKEPKTVAGTVAAAAPPPPPPNSAKPLPPTQVPGIHLSNASNHQLPATNGSSSASAAAARISVGSNAADRRYVNPSAPGAAPPIVVVSPDVPANEDRLGGDNPVTPPRVGALATRGLRPAPKDTIPISGKPPRKQRSSRFIVNEKVEIERLPAFSETPASERPQLFIKKLHQCAVLFDFNDANSELKGKQIKTQTLHEMLEYITSQRGVITENIYPEVVKMFATNLFRSIPPPVNPTGDAFDPEEDEPVLELAWPHLKIVYEFFLRFVESQDFNTNLAKRYIDQNFVLNLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAPIRRSINNVFFHFIYETERHNGIAELLEILGSIINGFALPLKEEHKTFLMRVLIPLHKVKSLSMYHPQLAYCVVQFLEKDATLAEEVVVGLLKYWPKVNSPKEVMFLSEMEEVLDVIDPTEFQKIQEPLFHQLARCINSQHFQVAERALMYWNNEYIVNLMGDNLSIILPIVFPALYTNSRSHWNRTIHALVYNALKLFMEINPDLFDEVMQQYKQRKIDERQHALARYDEWQKLREKALQNCGGKLPEGYVDIEPSPPPPPVEDLDIMDLSIDLNAVSIDAEAPLTELDESGIERVPMADPGMDRPFPEVGQEHPSPGGLHSRRKSALPVDPTVLRDLQAHRSLDDTVAPRGHVAGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSJ4</accession>
    <name>A0A2G8RSJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSJ4"/>
    <dbReference type="OrthoDB" id="2737768at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="214" mass="24410" checksum="2446B07B1C785141" modified="2018-01-31" version="1">MHILDQYKVPRESVDIEALVQRMAWYFKVAAEDTQFLHKHPARRDELFAELYKHPDVKPSVAANQFVPLGRDPDTHLIPADAEIERLTPPKTIEDRVARLHIAWAALMVYNKYKVRYPLLNHSDLGLQVDRRTTQIMDEWRDGEFVHMFPEHAARRAALQGPSIPTPPTQARLPTAPPARSSDPGPVGAPKRVSDDIRKNPKHYSAIFTNNSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSQ4</accession>
    <name>A0A2G8RSQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSQ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSQ4"/>
    <dbReference type="OrthoDB" id="722566at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="28052" checksum="23819687A1E68877" modified="2018-01-31" version="1">MTLALTAYFQFPLESPEFPESTSLPWYDAERGVPRLPHEGPPQILQMQYGPMRSGKLCYVQGVPKPASISIFPPPDEQSEGRLPDPNNPMHPLSSPHSAIVPRYYPLRTIVREAQDPASRDWRSESLVGLWLGDYGMHGTECLFLEHDVEEGMIRAWKITGDANVPRGACSWHAFLRQESPGTDETGREVRAYVGQGRIAHHGFIDSSLIAARVVISGKDEITVSWDMDFAPQTSKYIRYKAERARTGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT70</accession>
    <name>A0A2G8RT70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000057">
        <property type="protein sequence ID" value="PIL24548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT70"/>
    <dbReference type="OrthoDB" id="10667381at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="26454" checksum="829A5BAD4AE6D85A" modified="2018-01-31" version="1">MSSASLATCPSSNVFGLPLDDVDVPGGPDDAAPPEDGVPDVPELHDQGRDGDPAPPAPPAPPAPPAPPAPLPPPAPSVHQEAQNRTGFRPYPALAHKELPTRSSHPQGSLNERVLEHLMPQRLRIRSASPAPPPPEPERSLSPLIEAPVNAPAAPGLRRVFPNRPHSPLPSPTSSDDELDLIGRDSDEEALHAMLAGIEDVYSDPSFNYLSYDKALEVSFESVVELLAAVGLRTVTTTCVKLCNLPRCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTC6</accession>
    <name>A0A2G8RTC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12645</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTC6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTC6"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="320"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="726"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="771" mass="83958" checksum="720CE637613526D9" modified="2018-01-31" version="1">MATEEGLSNALNGVHIRSSPTSEPEPNPWQETSPTIPAANEHRNPDLSLLDADTTQGLAASSVPENAERPPVTQEVLREFDPLASAEEKAAQQAWASSEGHPPPPPVPTKEPASLAPPIPSTPNRPSSPVPAFPALAALARTFALPLTRNQRPRSLDSAAAVPSPATISSFAQQQSTPDARVVEDVANTSNGPVASGSGRNTPSGKDNEQEPPQFDFQKFLDQMKMKGAEPVAKYLRSFLSNFAKRTFTVNDQVKLINDFLNFISLRMRECEVWKGASDVEFDNAMEGMEKLVMNRLYDFTFTPQVIRVVPPRPVTTDDLERDRVLEQRIALFGWIEAKHLDVPEGEGSEGFLMFAQQELLKINHYKAPRDKLICILNCCKVIFGLIRHLHKDESADTFIPILIYVVIKGNPPHLLSNVEFINRFRNPTKLQSEAGYYLSSLMGAVSFIETMDHSSLSNITHEEFEKNVEEAIQSLPSTGSQTPERGITAGPGFDSGTPPLLSSAPSSHAGEESAQPLSLPTPGQSLGEDARRFLQKTGDTISKPLSAISRIFNEVLDGAEDTLSYLPGPFAPLELGREQQQQYDQEGHPHPAYTGPQTPGGPGEHQPPIQTPYKPRVRRGSPSPSIHSASSAQFPYVPQAQAQYEETPTRYRTQSLGPGPYTNQALAIGPSQSQVQAQGMLHPQRVQALQGLGTPPGHGHVSRTPTPNLDLAGLQEEIDRAHEKAAVAARETLRQIFPGTDVEVVEWVLEANEGDLGKSIEALLEMSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTR2</accession>
    <name>A0A2G8RTR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_12776</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTR2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTR2"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01672">
        <property type="entry name" value="TMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000679">
        <property type="entry name" value="Thymidylate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="10">
        <location>
            <begin position="13"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL24889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="230" mass="26005" checksum="ADD4A16E22EE6409" modified="2018-01-31" version="1">MSERKVRGAFIVVEGLDRSGKSSQVTLLEEHLKAEGVAVRLVKFPDRTTPIGKLIDSYLRSESEMDDRSIHLLFSANRWELAKSIQDSLESGTTVICDRYAFSGIAFSAAKNASGMSYEWCRGPDIALPAPDITLFLAVSPEQQRARGGFGEERYEKADFQERVEHVFERIGVEMGDGSRWFAVDADQRKEEVAQELWRLVQPLAKGTDRPLGRLWADLDERVRNAHLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU68</accession>
    <name>A0A2G8RU68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU68"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU68"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="247"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="468"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="500" mass="56359" checksum="FE71AEB19A8F7D56" modified="2018-01-31" version="1">MADVEMKPVDDKKEDEKPTESEKKPVPLTPVAEIKANVALIERAVSTLEPRFTHRVLRSLAQLRKKLDDKVLQDAVQEVYSTDSASKRALQSWLPTVTMDHSMDIDAATIPSRQVPTEPVPEVEIYFYLLILHHLLASPTNHSKATKLAHETVEKIQALNRRSMDPIAAKVWYAVERTYELGGELADARPLFLAGQRTAALRHDDETEASLINRILRSYLHYSLYDQADKLVSKTTFPPAAGNPQHARYHYYLGRIKAVQLNYTAAHTNLQQAIRRAPPAKTAPGFYQAVHKLSIVVELLMGDIPERSLFRHPVLEKALTGYFEIVKAVRNGSLSQFQTTLSRYAAQFEADKTYTLIVRLRQNVIKTGIRRLSLSYSRISLRDICVKLHLDSEEDAEYIVGKAIRDGVIEGRIVHEKGWMECGGQKSGYGPEVSDVFSRRVAYCLELHNQSVKAMRYPLNAHRKELAAAEGAREREKELAKEIQEGGDLDEDGPDLGDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUB3</accession>
    <name>A0A2G8RUB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_12978</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUB3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUB3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="26"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="532" mass="57090" checksum="56176B1C39313A9E" modified="2018-01-31" version="1">MPGGPAPTGAAIGASAPKSNIVGIALVGFAAFGGILFGYDTGTISGISTMDDWVRTFGHRDPSTTLGWILHTSDRSLVVSILSAGTFFGALGGAPIADIIGRRTGIMIASLVFSLGVALQTGAHNWATFIIGRLFAGFGVGLVSISVPMYQSECSPKSLRGAIVSGYQWAITIGILLANVINNATKDRQDHSSWQIPIAVQFVWAAVLAAGMVFLPESPRWLIKNGKEEAAARALGRLTSLSPSDPEIEIELNDIRAALAEEQKLGESSYADCFKSTHNKIFLRTLSGIFIQAWQQLTGINFIFYYGTTFFKNSGISDAFLISIATSIVNCFMTLPGMWGIEKFGRRALLLYGAAVMCICEFLVAIIGVTISLDNQSGQKALIALVCIYIAAFASTWGPIAWVITGEIFPLNVRAKAMSLSVASNWLWNWAIAYATPYLVDGGAGNADLGVKVFFIWGSTCAGCFVFTYFCIPETKGLSLEQIDLLYQNSTPITSVKYRRELIAQDLHVADLHAGQGEALGEKAELEESQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUH9</accession>
    <name>A0A2G8RUH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUH9"/>
    <dbReference type="OrthoDB" id="2742886at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="123"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="356" mass="40007" checksum="2E7E32A60987602D" modified="2018-01-31" version="1">MGTDMPPSSAYHGTPTPALELEEFDLSTLGTIKDQAVLAKLVRANKISQVDYRKAIAALCRKDEPPPRLEDIQILYSATTPPVISPAEVLERLQRPIRTADAIQSFRVDKISDTVIVKYGRVLHAELETMLFVKQHTRIPVPTVHLLFVLGEDTYLVMEYIPGGDLQHLWPSLQEAERQLVLSQLQQYLHDLHAITPPSTIPGPIGGGVCRGCWFSEFGAGPFKSHQELVEWWNSKLPPADDPCGNPSDTGERLQADHPLVFTHGDIAPRNLILRDGVVWVLDWEQAGWYPAYLEYAFIASETGSWEDPTPKDWKDAMLSLIPHYKREHEILIRAYPRIARGFDPILLGARAQKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUL4</accession>
    <name>A0A2G8RUL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUL4"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058504">
        <property type="entry name" value="DUF8191"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26609">
        <property type="entry name" value="DUF8191"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="252"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="557" mass="63248" checksum="4AC5BAFCEC666701" modified="2018-01-31" version="1">MPPVVTQNTSSSNRRSTGSIRQRENRALVPAGTGSTRRRRSRSPDARAIDEAPPQLDIVLRRKKRSSHANGGGTPSSNAANMALVRTSVLDDSGDRGRIKPKPRSKALMWVDDEDDDIVTNIVHDNGRSSNAQNARSKRKERSRSRDAPHRNSRKAATPNESTEDEDDPMYTGPLAQAEYTRMKQEVETMRKQVAMAKKTIGRQSKVIDELRSELSTTDELHRSQRVEMEKLKRITKKSDDLIATMETNLTCQICMEILLKPYGLSPCGHVLCVTCLQGWFKNAPAGDDDMMDDDYPDALLYRKKTCPCCRAVVRSRPIPLYLVKSIASALDKSKAPAGAARPSPPPDDEDPWAGIFRDHTEADDYWSTDHDEDDEDEEDEDDEDEDGEDGEGYDDEDGYWSFDGYGTAEEDERYDGPYVRAQWAPPTVPVSQEEYPFLEEDAEEFSMLRRGVTLQMIELFQMSYCHNTGLCAMVDGENEVHLGFNIELHPDDETGEEYIDWVLADIYGRPERWRVENDHRQGTWSAWRLIPAEEVEEYDNTDSEVWADEMVDDDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUQ4</accession>
    <name>A0A2G8RUQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUQ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUQ4"/>
    <dbReference type="OrthoDB" id="2796844at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="2">
        <location>
            <begin position="330"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="605" mass="66523" checksum="26788BA1CB89AEDE" modified="2018-01-31" version="1">MLCLMSSASLATCPSSNVFGLPLDNVDVPGGPDNATPPEDGVHDVPELHNQGGDDDYDDPAPPAPPVPQPVPPPPPSPPPAPPPVPSPSPPPARPPPAPVARPPAPSVHQEAQNCAGLRPYPALARKELPACSSYPQGSLNDCTSSDDELDLIGRDSDEEALHVMLAGIEDIYSDPSFDYLSYDEALEVSFKSVVEQASKANQEHFGEPWSMSEVMVLEPEECNKWLKVAQDELQSLVENGTFELVLLPSGRKAIGFWWVFWVKRNADGSIECYKGRPIAKGFSQRPGFEPPSEPSLLWQLSKTSNSTQGGGVHVPDDSAVGVAPSQGSHGLKQAGWCWHEKLDKVLNQLGFEQLTCKHSVWVYLCDGVRLIIPVFVDDITIAGKDKAVIQRVKDNLRKHFKLQDLGPTSWLLGVQIKRDHSKCFLSISQRQYALDIVKRYGFSNCDPHPGMAHWKAVKHLFCYIKGTLDYKLTYVLSPELELFTSFTDAGCPDTGCSTSGTRAISWSSRLQSLVALSTTEAEFIAAVSCAQEMLWLCNLLTEFGYNVSSASKLLIDNLSALSVAKNPEHHGRMKHLDLRFYWLQDEVATLRLYIYALHTCQQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVG5</accession>
    <name>A0A2G8RVG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13393</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVG5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVG5"/>
    <dbReference type="OrthoDB" id="2746049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="58"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="665" mass="71182" checksum="2A4143C44E7954CC" modified="2018-01-31" version="1">MIFLQAKNDPNVVAQRFLDGLQHGQYKLGHETLKDLNSTVTLLLAFVRHQMNAHAPIHALPTELLQLVFAHTLAPPAAFLPFDPRGARADPRAEARRTLALTHVCRRWRHIALDTGALWTRIAHAHTPGNGSPAGSEGSTNSDSACAAAFFARSKAASLDVHAPFPASQFLRTALAPHAGRIRSLALTLPAEERSTIPTPSASGDNSALALPFALPNLESLALTTECDPFDDRRPLLDLHAPCALFSPSSGTPNEDDDEEREDDGGTPRLRRLLLRNMCWVPRAPLGQLTHLFLTEGTSVPLPALLSFLARCAALEVLVLADVYVDVAGSITPLPPSPENRVALPKLRRCTLGIGGALLNMRRVLTHVAFPPDVTLRVSGSKAFHALSHLAPFPDLAFAQVLDTLSVDFAPHGKPGAGIVIRASGPSPSPTGDKVNGDAERRGPGLLLEFPTYRGTPAECVLMRGLMRALVPLARLVDVRYRVCPHQKEPLHVLGGDDVSLDALKTFRLVEGTCAHQDRDHGGEVLGEAVRKVLGRCPGLEEVEVWAEDSAALREHIGNVAVCRGSSSPPMEIAGTDIDWAESPFEWTRAGWGGGAGVLGPTLEEVQVWVGKGDKGMPARLVPGGSPAPALARMVVHCSSLGGGMREGDMEIPGTDIDWVDSPFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVK3</accession>
    <name>A0A2G8RVK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000047">
        <property type="protein sequence ID" value="PIL25542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVK3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="12835" checksum="9CB40E62A98309B2" modified="2018-01-31" version="1">MAVVRGLPAVLADLGFFSPSRKSSDSPLPTHGSTHTHSSHTLALWGVPEVSTSAQDDCFEAGVIGAISFTDVRWSIDGRGCGPEQMLGCTRNEDPRRLPKVATRTTDWLVTVTLLIPGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWK2</accession>
    <name>A0A2G8RWK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWK2"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="129" mass="14347" checksum="5E039469DAAF29E3" modified="2018-01-31" version="1">MNSRGGSATALRRLMTEYKQLTSQGAPDGMFTAGPISESDFFTWEALIVGPKDTPFEGGVFPAILTFPSDYPLSPFKMKFDPPLFHPNSTSRQIQVLKCGMPALYKPCFCLKATTDRLAARRRVHPRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWT4</accession>
    <name>A0A2G8RWT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWT4"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="37817" checksum="A1B2C4AAEC085B1F" modified="2018-01-31" version="1">MSSSSAVPQLNKIFLIGIWIETALWGVNTVVFAGVCYVLFWKSKANNSRVLGVTSLLLYLVVTLHVSASLRQELEAFIYTPSPPSADYASLYFLQEGSTFAAMKNVLYTTAVFIQDLVLIWRMYVVWARNWKIIVIPLTVELVHIGCAYAAVILLTQPNAGIYTPTLSTLGSLGWPLGAIASRMWFMGRTLSRVEAGSLGGAGRTRSNAYVAPIFTIVESGAILVAVTVTMLALYKTGNPAALMCTDIATQIAALVPYLIIVRVGLGLTHGLPNAYKSYMETTKSMGGGQGMTFAPNRILKLGTKSSQSYVCGTFSDTVTSTAQAESIALSDFEAKMRSQESLKRSGMNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWT9</accession>
    <name>A0A2G8RWT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase I associated factor, A49-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWT9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWT9"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL25986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47060" checksum="DA269A5959E79E82" modified="2018-01-31" version="1">MASSAISKKRKRGADDEEKVSLQLSLDAASKVGPVLASFPSLNPPKNTAFQCYAQKTRDKSVPFETQPTLVVGETETVEFFSADGPLQSTGCSYMIGVHDKRTNATTLRPAPLHVLTRQVKALKNLKPIEVSTEERMAQRNNLGETFGTKKAKAAIRARERNRVDIDAMRDVAGHLQDTIMANTDSLPTAEEAKATADSSRLIPPYNEDAQRPQDVYALHDVIPEAEFNAIPVNAFKSAKTPQERYSLLPWSRSDWVKLQLRLIYSAPKPDKRDLKTVYYISTMMAFYKSSRTVGDKDALQHKLPGVPTIILDGLTSRFTEKERSTNKPKMTPQTQTMLLSYMFALCLRIDDYATDTEGVAHDLGMSPASVNSLFKSLGCTIKKLSPTELKERGLPDAAAETKRAVLKIPLEFPKSRIKRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX03</accession>
    <name>A0A2G8RX03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11803</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX03"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX03"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573928" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL26049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="30380" checksum="851A777C129FB749" modified="2018-01-31" version="1">MHHWTYLIRAITAVSFFHSAMACDVLLSNDDGWAGAFIRAQRDSLVNAGFNVVLSGLAQDMSDRGASSAPLQPLAEPCQFNTCPTGSPAEGFNASDPRLNYVNAFAVDAVRYGIQTLSPKIFCSPPEFVISGPNSGPLLGVGTPTSSAIAVACEAAKEGFPAVAFAAGTATKISYTTLTTLPNSRNTLSALLYAELSSNFTHALVDPVPRPILPGGVFLRVNYAPTTFSASGRPTGKCIAASDYKWVLTRQQPGNAVSTVGTCGSKRLPVDRGATRLSQCSTRRQGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXP7</accession>
    <name>A0A2G8RXP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_12038</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXP7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXP7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL26282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="57696" checksum="10C08B048E4031DB" modified="2018-01-31" version="1">MGSSLISGDTCTFLGWAVLALVVLVLRNRWRPRKRLPPGPSTLPVLGSIHHLTLEFQQKRFAELGKEFGDVIYLKLFRTPAIVLNSLESARELLDKRSAKYSDRTRAVLLAELIGHDLSLPFLRYGERFRKHRRWMHDAVGSKASLLKYRPMQIREAHLLLRNLLETPDNFIEHLYRYVAGTLLEITYGQRLTSMNDLIVQLAERAVIATNESGSPGSMVVDFFPILKHLPTWLPIAGFKRHALKAREDLNAWKNTGLNIVRSAMASGTASASVTSALLEAHQGHLGEEELEDIKAVGTSIYGAGTETTYGSLASFVLAMVRSSDVLRKAQDEMDRVVGHTRLPGLGDRDSLPYLSALVEEVYRWNPGLALAIPHRAISDDEYRGYDIPEGCMIMPNIWAMTRDERFYPQPEEFLPDRHLNENGDGLAQDRELPSTYVFGFGRRICPGQAFADAVLWLAIAHIVAAFDIRPVVDAFGVPVVPPAAFKPGFTSQPARFQCNIVPRSEKIAAAIAHLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXU8</accession>
    <name>A0A2G8RXU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXU8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXU8"/>
    <dbReference type="OrthoDB" id="10006218at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="367" mass="42401" checksum="A0A337704A18532C" modified="2018-01-31" version="1">MLKLPLLGQRHPRYTIALAGLVLCAYWFLSSSAPPLRPVHYNANHELKARLEREERKYRDMVPQRHDLITKFGPTPAQVVMFPPDQDPWPAYTVWDFFPPVFNCPHELDRLGALGDGGKWICGISRIQDKPDCVVYSFGIDSSYSFEAVLLQSTRFCQVWIYDSTKGDGAKNHIPRSLRHRVHFAKLALGATDRHGASDDPKRWTLRSLMSENGHSHIDFLRLDVEGWEWETFRAIIRDFTMERGSPANGASVWGVPEREGVLPFGQLQIELHVWNQRFQDFLEWWELLEIAGLRPFHNEINLIYANYNRGSGVELAEYSFLNVRGENAFIKDYVPVEPETDHVARENEQEAERLQRIRHGAGPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYU1</accession>
    <name>A0A2G8RYU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11258</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000041">
        <property type="protein sequence ID" value="PIL26682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYU1"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="487"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="531" mass="58234" checksum="6649EB832F476600" modified="2018-01-31" version="1">MSSAVSSYADLPAIRSALFNNPPDTVPPTDELEILHAELTAYKVKSLELAKKAGDDIRTIEESMRRLKEKEKGKAKAIQKAERERAFTPSINGDESRASAQPLSQPLRTRPSSVPVPPMPTPQPSRPNLVEELKKNKKKKRKREDSSDLEPEPPKTRKPSPLPAHTHPHPPPPPQKPNKYPSTSLAFSKPANAPAFDLPTSVPLLSARPPVAPRPVAGPSKPTEVMEDFSKSKQPSQVQVNTFYTSIEPWMRPVKEEDVGFLQYTADEVEPFIMPKLGRHYSALWEEEDIAQYGGPLPGTAAMRVPDYSEAVDDPIATALRHAQRELRTVLATNKVRRARLAAIAEDRLAYQEYVDGRDAIDKNIQTLYGKLQKKDGPKVNKKKKQKGDPPPGMNGTAALTGMAALPPCPAALGLSPDEHNQLHIPEQLSDLVRTRRNWVDIVGGVFEDKERIQPGRIVGFPAESVYEGIDDEVRLELERISSKVASSAASVRPTLTTNGHHGHGHGHGHGYGHAASSKGKGRAGDEMDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZL2</accession>
    <name>A0A2G8RZL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZL2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZL2"/>
    <dbReference type="OrthoDB" id="2726860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="316" mass="35971" checksum="9D916D05AC62F46C" modified="2018-01-31" version="1">MWLLSSSRAELHFFPSPESVPGGYAILSHVWGPDEQSFQSIQALRKSCAKSGGNPRDHVSDKIRECCKLAEKRGYDWVWVDTCCIDKTSSTELSEAINSMFRYYSLAKVCYAFLADVPTGTDMIALSSEDSAFRRSRWHKRGWTLQELLAPPELLFVSERWEMLGSKADLSDVLQQVTRVPADVLLNREEFINTSVAQRMSWAAGRVTTRLEDEAYCLMGIFRVNMPTLYGEGRQAFRRLQQEIMRHYADTSLFAWGNAPPEALTDLMRLYRFPSRDRSTGHVLPERDALWSTLADCIILLGLQVDCQASGKYFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZS0</accession>
    <name>A0A2G8RZS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 43 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZS0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZS0"/>
    <dbReference type="OrthoDB" id="2730619at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043750">
        <property type="entry name" value="DUF5695"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18951">
        <property type="entry name" value="DUF5695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013883344" description="Glycoside hydrolase family 43 protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="903" mass="98739" checksum="BAD724DEE9125EDB" modified="2018-01-31" version="1">MRTSYFATVLPALFAASFSAAQTPTLGLQDGFLNFTTPSFNVQLVKDSQTLYSLTTKDSTAFDFIPADVMTQRQYNGNYHLGDLTFRARIVGSSTWISGDTAAARKNVSALSASGSTLAAANLLPTLPSGSLLNITRRWVLKDGSFQLLFDVTNSQSQAVEIGSLGAPLEFNNIFTGRTSAQTNELCSLFDPYIGQDAGYVQVTPLLGTLPPLLVLPVGKSPLEGWRFLPENTSQPLAYQSQTFEALYEWQFHSLAYAENEWKNATPWNAPTSATLQPGETRTYGFQFVLADSIRGIEDALQAAERPVAVGIPGYIVPSDQQAKLFLNYPSKVASLSVSPAGALSWTTNSEAKTSGWVGYTLTAKTWGRSRLTVTYADGTVQTVHYYVTKAAAQAIADLGNFLTTESWFDDPTDPFARSPSVITFDREVNAVVRNDPRAWIPGLSDEAGAGSWLAATVKQFAQPNAAEVAKLEQFVNETLWGSVQNPDGTVKKAVFFYEPDLVPNYTYPSSIFWGNWWSWNQAASFATDRAYDYVHVIAAYWSLYRVARNYPALVQNTWQWYINQAVLTVSTMTNGRVGYADDGLMEETVILYLLNDLKREGLTTNASLVESRMQAREKVWAGERYPFGSEMAWDSTGQEGVFAWATYFNDSTTALNSLNSILAYQPTVPHWGYNGNARRYWDNVYGGKLQRIERQIHHYGSGLNAIPLVTQFRITPADYYLLRVGFGGLSGPLSNIDQGGFASASFHSFEDTLKWDGYSGDYGPNFVGHALEMGTYIVDHPDFGWQAFGGNVVATTPTVRVQTRDSLRRRVFVAPLGAWLSLDAGAFEEVDFDPASNKVTLTIVPSASGISGAAAAPSARLVVQNTANNGLGVLKPTTSLSQDAGAWVIPFKNGVASVSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0A6</accession>
    <name>A0A2G8S0A6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0A6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0A6"/>
    <dbReference type="OrthoDB" id="2649786at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="716"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="851" mass="91773" checksum="CC5AE8953C66950B" modified="2018-01-31" version="1">MNALNHALNHPIKPPTYSQSRLVWQTLTQNQPHTHPQDSRNGIHSMATSSSPSSTHTTVDMQLVEYTFARWVYIDKCQDFVDQYGSSIPDISGIVDILGSETACIRALILHGQRPRSDLEYDSMAKDRQTRYSYAKGVRGLTPLEAFQEALRIGLAAAKLLNATKVDIPTRPWERTSRSIHWLASRFFVPRAGRPIFIPHPLTGPSSLWYTANPSGPSTASGTDLISAPRELYAIQTRAAGNMQDDLSAMWSCSDVDILYRNGECTAYPRLPNMKPFVVTGLPPVHLHVLHHPKPNPKSGNFHTTARSVSRQDVKDTPMLLLWSCIHGDLFVQAPKQVQALPPISSFNFVNPPIPSSSISPPGSTSLQQYALAYQSRYHPPPLSASHAYPVPQPQFQPMLCVSYSHAHQNQAPTLPSSSLRPVPGMPPFAQLSIQRGYVRGPTNSQTQAPAVSTRQHAQALPLPQAAPRPTPSLSVFQPRAPPTFTDVRPSSRGAAPSVSVSEKRARRSDPVPGPSSNSTRRSAKPSPPISSASAPTPSASAPTLSACPLTPSASAPTPSTSVPTSSTFSPTSTSAPSSLACAPTSSTSASTSAPAPSTSTVRAPLTSSPASSTTPADPTSPAHRRAPEEKTPCGLDNCTVNLTPSSWETHYATAHKISEATWVPDSLCTHPACREAQAAAASSPRTQPKLTLGIWATYKRHVKQMHFPTGRTHPCTFPGCDAVLSRADALLRHVEAKHKVAYDGRERTGKRARTDDEEWSPRKKARGGTSPTKAQTQRAMGSPKKTSAARDKASVALISSSSRKGKEVARDGNHSQNRSPSLIRPDHKLAISKRLGGLKTNSKLGSYPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0U1</accession>
    <name>A0A2G8S0U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_10504</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0U1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0U1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL27357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="517" mass="58157" checksum="872EF03495833E35" modified="2018-01-31" version="1">MPALGEWNTTTVLASLAWAGALCLFLFFTRLTAKSVSGARIPPGPRGWPIIGCFTHLAKYPELTLNKWAKQYGSLFSFTIGNQLFVAISDPNIVKDLVITNGAIFSSRKDMYMKAQLVFARRGVTATQYNDTWRKHRRLAAMFLTTRAVAAYMPGLEREAKEMIHDLYVRSQAGALPINPQRFASRASLNNILTLTFGFLTESIDDQLVSDSLRLSREFMNTTGPVANLVDFIPLLQKLPNHMATRGRALNRELVDICGAMIRDIDAALKRGDPYPDCMAKYLLQNRKAEHLDDLDIIVLCGAFMIGGVETTSSVKQWFAAHIPTLPAVQARARAELDSVCGRDRLPTAEDEAKMPYIHAIVKEIERCHNPFWLGTPHMNTEDYVYNGFLIPKDTVIVLNTWNMHHNPERHPDPHEFKPERYIDDSLTCAESANLANPMERDHWTFGAGRRICPGIALAEREIFLAVSHLLWAFQMDEMPEAPIDLKEYDGLSGRSPVPNRIRLTPRDEHVATILGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1I2</accession>
    <name>A0A2G8S1I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1I2"/>
    <dbReference type="OrthoDB" id="1938262at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="273"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="659" mass="73693" checksum="B4EE3C0554672C3A" modified="2018-01-31" version="1">MRLLDTLTGQFAEVVDHNSIRYAILSHTWESIRGEPQEQTYEEIKEIQQLYASQPNSRSLSLPPSTSSTQSIAPQQYASSNPPYHRHSSHTLSILADRRVSEKIRRACAIACTQGYRYIWIDSSCINKTSSSELSEAINSMFVWYRDSAVCYAFLADVPRDEDLRAPGSRFRYSRWFKRGWTLQELIAPRDVVFLSREWSVLGSKSSLSSLIEEITGIPHSILTHKLPLAKVSVAVRMSWASHRETSRTEDKAYSLMGIFDISIAPLYGEGERAFVRLQTEILRSLPDQSIFAWGKLSLNPLPLPGSHREDRDARRLGCITTGSLLASSPRDFDGASGTVRPLPHDTYFQRLGVTDHPLPDYAPTPYGLRASLPLLALVPTLGRTHSSPSSISGVLSGDGNQWFLILLPCEHRQQEGSLLGRICHVKSAQAASVLHAGACSVLPDTEELPHGGNSYDLLNQSTLSGLFVISSNQLRRCRRHVSFRTIYMPFPTTEAVALRTPTQWSLETLRLRLCARSVAVLETQGFTATLSEPSRESHGLATYKLRVQDSSARSSTRWTLRLDFGRPHEREASNGVCVQVRVKDQSSHQHPIRRIWVPSARRFELCHLKLRSNGGVHVSVELGLEFESMSDPCYLCVSIDDSDEEEEAREAQPGVLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1K1</accession>
    <name>A0A2G8S1K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10801</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1K1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1K1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="306"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="405"/>
            <end position="408"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="493" mass="55556" checksum="FCC4932A8A87263A" modified="2018-01-31" version="1">MLGRFMQGKDTAGPDGRASQWPPYPPPGETDLEKVLRLEGEREAKKVSDEIDHELEMERQTTRKKQKGEKRLLLLGQSESGKSTLLKNFQLYFTPKALRAESDAWRAVIHLNLVHSVNFIIDLLINTAASNAASNSTTYHPHGGRPRTSVEDDAPVASGLSSHTPQLSSEIRRYKLSLSPLRQVEKILARQLSTDEAESPSSPSSRFFGRPSEVVVRGGRGWKSLLRRKAQDGTQQQRSTADPALENARRILDACRGDIVALWRSESVQAGLREEGVVMREQSGFFLDQAERVANMSYEPTLDDILRARLETLGVEEHRLVMETTAEAGQHWVFFDVGGARGQRASWVPFFEDVHAIIFMCSTAGFNEVLQEDRGINRLLDSFNLWKTICSSKLLTSVQFILLLNKTDILDARLKAGVKFSSYVKSYKDENDLSHVLDYLRMKFAAMHHHHSPERRALHVHSTCAINIHTTSTVLVQIRDTILVNYLKATEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1W7</accession>
    <name>A0A2G8S1W7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor eIF4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1W7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1W7"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="47972" checksum="A45701AD2087A072" modified="2018-01-31" version="1">MSTSPPPATTSPDAPAKSDRPSAGTRMPSLNQLAARINLNAPTPATAGNRPRLAASLLRTSSQSSTPSSTAPSTADSILVNAPTSRSESPGALSVSPPHSNGGTPLGEQPGEPLTADKVEQLNHETAAAPASADEKKARQKMPVGYKNIPSLDAITARLAKARTLSIDGSAKPPEAETIEDPKTPGLMIKAPEHPLEHPWTIFHDTKSKVPFTPASDGPSAAAAAAHYVAPESDEYEAGLTVIGEFDTVESFCRYFNWLKPPSKLERNSNYHLFKSGIKPMWEDEANARGGKWVLTMKNNPQLLDRCWSWLAMALVGEDLDEGDEICGAVVSLRSKVDRIQLWTRSKEDVEKINGIARKMVKLLDVSEADGIGLEFQYNNDDRPVPNKFLSIQAIPQSSYRTSFHGKPPGFNSPVSGPGEGPQLGGGPGGAFAGFGVGGGGVLGSGWRGKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2E8</accession>
    <name>A0A2G8S2E8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2E8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="259" mass="28650" checksum="17BA81F40FF4098B" modified="2018-01-31" version="1">MLALRCPVRRLTINTLNLEAIGAVQPRHLVLAPLQLPFYIAPPRPSQAHATAHPYLTHLVVISSFHSDDYFGGKISTVFRRSSALRADIAFERLVQTISLFTNVTCVRLVFYCYKDGPCENELGSFMRDIRAHAAESAGTQFAPPPHLLAACSQLRYFFVTAVGRDHSTPSAIPSQPRWNHARAWQVVDVEPGEGAQLLSGGSSDASATPIVEELCDRSARRVIEAEDLGLPEEWERQRGSLETTFAFYGKKCEASLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2X7</accession>
    <name>A0A2G8S2X7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2X7"/>
    <dbReference type="OrthoDB" id="2797568at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="782"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="849" mass="95901" checksum="C5A192B616EE9CC9" modified="2018-01-31" version="1">MTLSTNDISSVCFCPCSSEDIRQESTLEGWRKELHRRIIPSEDSRVDFLHKYVPSRTPCPPPGDVTDAFAKFAQWVPQEENSHQLLIEGLAALVSSFPADKRPSFLDCLKYAQRFPFSTFENKHRSVYLDIAVSFPGQAFAEDEYPNWFSFSSVMKSKPEGKEDPFKKRRHKPCKALIQLAVLTHNLMHAHGLTCAFIFGIYGDTIRICRFDHSGAVVCQPLSLKNVADLKILQQFFWNFVHPTEEGPFVGWDPTVRRLNADEEEWLLARLERANVDTQQLILSEARFVQVFDGEPESDGGREPQTYITFNLLDASTRLFSRATTVWRAIRDTRRRVDGRLVDPPSFADDLKVRIIKEAWRPLLRRSEKDFYDRLDSAIPPHQRVGLPSLVCGSDMGEREVRLWESALYGAFEPIAPDGAHHKSRLSAPASQKPLSSAPLPPSLSGPGGQSDLPIHRPLQQTFTWRQARGAKYWYRERSHVRLVVGEVGRPVTRFRSTKELVRAFPRDAIIGHRNAMAKGGILHRDISVGNILIVDDPALQDQFCGFIHDFDYSSMTGEVPQNDILSLPAEAVDELLLADDIYGFLIQRTGTWNYMATELIPACSVRVVHAIRHDLESFYWTLLWVVLRHTSTRQTVTSRKPKTRQQVCADVFTKDSPQLAAGSKLIWLGYSAKNLEIARNRPLTALMKAFALLVNDGPGVPGMNLDYDNVLGLFDAALAAESWPEVGDGPLEYVSESSEELSSDRPHRHRRKRARARASKRKGKGRKTTADPEWSSSVLDGDSDDEEPWESDDDDAPRLAINGADDEDCDEDDQDCDKDDEVHCDQDSVDFGCEFPPTAALSYSDRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3J1</accession>
    <name>A0A2G8S3J1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3J1"/>
    <dbReference type="OrthoDB" id="2797568at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="927"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1026" mass="113604" checksum="93A6352602101C39" modified="2018-01-31" version="1">MPEFEYIDCQKFVVELGMLEARTVLNNNKRYASVVRFEAGCMSCTKKFLRKYVPSSVPYKPVGNIGAAFASWAPKKGREVDYPQLVSGFSALVASFPAQKQLFFIDGHEDAQRFPFEAFAHKHHDVFADLVVSFPGRSIEANNARPKLSDIAMIMMMNSEHGYDPFKTDGLKHCKTVVQLAAHARNLMHAHGLTCAFVLGIYGDVLRICRFDRSGAVVSQPINLKDVDELEIVQEFFWRFVHPTEDVPFVGWDPTVRKLTCADREWLKARLDLANFDTKGALPFTEARRAEIFDDGSGGVAVDPRAYILFKAINVNGRLFSRGTTVWYGIRDTRISLDGCVVDPPGNVSPEDLKVRVIKDAWRQLGRRPETEFYRRLSIIPANDRVGLPSMVCGGDLGEREVQDWESALYGGPTPTPISADHHQSRLGRPASPLRVGPSSSPPASLFTSTSSPQLPVHRPVQQTFTWRQARGTEYWHRERSHIRFVIDEVGRPVTQFKNTRELTTAFRDAILGHRNAMRKGGILHRDISVGNILIVDDPDQQEQFCGFIHDFDYSSMSRDVPQGDISSLSATALSELLMADDVDGRLKERTGTFLFMSDELLVSHGPIVHDVRHDIHSFYWVLLWVVLRHTRHNLSDSTTAVDPLDACAKVFKQSSSLDAANAKRGWMWDCRYLVITGNGPLTALLSEYARLIGKTSYPERLPLDYDEVLDIFDRALAREDWPQSNDGPVRYTLPTLSPVNGWVFENPTPKPEKKSVHAHGKGEGKAAQVSSDSDSDSGDEIDENYVNELYYSDDEPDVHAHADEHMRNDADAALRALDVRGPRQDLPPLPPLNFSERLRIRDDDDDDDWGDAAEVSALIGHGGDNSDSDDGDIPMDAHDDSNVPSGDYHKLPSLLGRLKMALPRKKKKVAPAPGPDTAESAAAGPSRVTRGATRRAAGTSASAATPSQLNSGSGPEQPPTRVGPKTRARTRNGGETETVDTPHSGWSDRSGPRTRSATRGGNSGTTRSGGRSQTRSGGGRRARGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3K2</accession>
    <name>A0A2G8S3K2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3K2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="128" mass="14329" checksum="D6CFE721A2BE6474" modified="2018-01-31" version="1">MLTTASQSATRTSGYSPSNSPCTPPLIPPFLEALRHRAAHQRSLRDLQARVPTFDVQPTWRVTRRPGPPLTNLKVKLKREKAKEKMKGPGEEEDALALGRQASARRSDQNASGKTKLRASRWRPYGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S445</accession>
    <name>A0A2G8S445_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S445"/>
    <dbReference type="OrthoDB" id="10661741at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="356" mass="38045" checksum="7ED8127F9C8B4EA0" modified="2018-01-31" version="1">MVTIALKSEVLFAIIGVGSVFVIVCVAAAICYTCQRRNRRSKGESRGKKGDITEELPARTHSKRNARTKAEEGVPKEAVPPMEEETKIEASAPPFRVVQLPPGGLPPPSPPFAQPRFSQSARLDPQLSQQTFSTFESFYRAQGETSSSVPPSPHSPSGAWPSQPTARRTSTRAAARLTNATLADIALPPTPTKLAMTGTWTGAPQEPNHASLRTSSSSPPQRVRTRRPMADIIPPPAAGSPRSQTFQTGEVPRSPRPPNPAAVRGRPSASSALASRPRSRSVGSSTVPPPGHRELRRVGTKQVPPVARSRSAVSRSLDGGSRPVGGQPSRPLPASTSRAPRRPHTAEDQARSYFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4H7</accession>
    <name>A0A2G8S4H7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4H7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4H7"/>
    <dbReference type="OrthoDB" id="2971182at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="179"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="352" mass="38160" checksum="4BA0EA45D51E4011" modified="2018-01-31" version="1">MSNQSTLPQAELARVREGLACIIIGVVAASILFGITVLQAYIYYRENVKEPTVVKFLVGLVCFFDTSATVFITIGAWIFFVQDFGNQADMPVVKGPPAEALVIGANVFTALITQLFFAYRLWIFSKQNIVLAGIVVVFALGSFAPGLWIASRFVEAASLFDIQTTKARIIGGLWNGLGAICDVFILLVLSCYLHTSRLRSKRSSDSVDEKLMQYMIECCGITALCQTCILVTFSALPGRVVFFPFLLIVGKLYSNTFLGTLNVRQKMTRATNTGRQDLGPDALATLGQLCNISVDPHSSQPTDAGIQTMSEVCIGSPSTGSEASDPWRKALVGEPDRHGAGVCVFSDVKQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4X1</accession>
    <name>A0A2G8S4X1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4X1"/>
    <dbReference type="OrthoDB" id="2748713at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="145" mass="16078" checksum="0BCF522FC52B9316" modified="2018-01-31" version="1">MERSLARHTPSGHRHLHALTHFRLVFHCFAREAEDPGRRISEEPLVDDLRPSSGFHFNAVASAIADALPSLQYCFLTNSARVVETKIAHADILVECWCESRAWRVVPQAPIGDNGIDHPEAMTAADTRGLHVETSENGSPECSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5T1</accession>
    <name>A0A2G8S5T1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5T1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="23106" checksum="B1A35F9A70AA25DF" modified="2018-01-31" version="1">MSTENSPIVQFYELSVVSDYMGFVGITLLALDWVLNFDREVAMFWKRPKSLAPLLYFANSCNDLMLAAYAFACIQYLPVAFFSAMRAHGLGKNIVLSALILLLSLVPLGTNLAAYGAGIQGDIVPLIGCLQSESFPQEVYIPILPAFNIAVNTNLMLQLISPRTIRLGPDDPLYTAASGVGGQEGSLNFAHVLGSLGAIIDPNAVGEDFAIGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S636</accession>
    <name>A0A2G8S636_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_09298</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S636"/>
    <dbReference type="STRING" id="1077348.A0A2G8S636"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013735342" evidence="15">
        <location>
            <begin position="24"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL29249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="523" mass="58811" checksum="82B549AAC93F9ED5" modified="2018-01-31" version="1">MIDLPQWFILSVIVVTLLYKVRQSRSTSGKLPLPPSPPGYPIIGNFLDVPVHNMEPAFRDINAKYGEIVYLNACGQPMIVLGSHQAAIDLLEKRSSNYSDRLFSCVASLSGWTWLFSVNSYGAQWRRTRRLFHEYMHPNAVLRYRPIQEREAAKYLLHILETPKDFLHHGRALFGTITIRVGYGIEVDKEKGTDYLGIAEKAMETFSQLFLPGKYLVESFPIMRFIPYPLPGTQFKRDAADCYSIVRKMRDTPWEAAMNALREGRGLPSMASGLLERMAHLDGEAAADEEEFSKNAIASAYAGGADTTLSTLQTFYIAMSSYPEVQKRAQAELEAVVGPHRLPTFADKNDLPYIAALIKECLRWRPVVPLALVHLSIEEDEYKGYRIPARSAVVANPWAYVRDPNLYPDPETFKPERFLKDGKLDPSVQDPTTIIFGYGRRICPGRYFAEGSVYAVVTAILHTMNIEAPRDASGAPVNLKDTVKMTHGVISYPEPFECVIKPRSSEAEMLIRTACNEDDSVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S648</accession>
    <name>A0A2G8S648_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S648"/>
    <dbReference type="OrthoDB" id="2748248at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="56022" checksum="08CED60FE8EB1570" modified="2018-01-31" version="1">MEVFAYIVPTSCRALNLLHVCRKWRYVAIKTPEFWSDLLRIPAVTRAAVRGDPNGIDRFRTFLRRSAPIRIAFNASCLPLHVSEVIGAHLNQIGGLKVRVGGDEAVALCSWLREGMPVLQELEIFHKATCPLEPADRNVFHSLTCSDAALPRLRTLRVSPAFFGPGLAVQSLHTLHIGGCSCDDCRGDAKAYTLEDLFSFLKRSPSLSSIKFSLGSEPLHWPAGSSPVQPIALSALKNLTFEHYQVDSLRDMLSNLIIPPTAIVRVTSENFTQEGGPYFPSSLRKLPLPWDLRSLRVVVSSCSCDLLGANLRTEAGRIKIGWKTLGVLGRRTELFREFAQLFASPAVSRLHISVASNLYPTCLDRARMAALLGAFPQLTFLRVGRKCHDLFRYLAQAEEGAKSSAGGDKAGSGSGEARGVPCRHLDHLIALWSVSWEEEFRTSCDLVEKTLAQRAALGSRLSILDLRFRRLYGLKPGQGEVDLEEIRSGLVRRLRPLAGMVVVTIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S673</accession>
    <name>A0A2G8S673_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_09086</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S673"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="475"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="1267"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="1390"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="576"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="167"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="330"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="576"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="596"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL29038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1406" mass="152618" checksum="DA2E6E38B605E16F" modified="2018-01-31" version="1">MSGKAPPRAPRALLNSLHGSAAAAASASSSPNPSAFSASRIGATPPTGPRSLLNGQAGARGRGGKPYVNGHAGIPTGPAAAPPNGPSVLKGKQVDVGWAQQGSSSGAQPNGAGPSRAAHPQEPTTALNARHTAISFKLRPSASSSSSRSANSDGPQPPTSPRLKAFAPPPSSPGPPPPPPPSEPPPPPPPPTTDPPPPPPPSTEPPPPPPPSNEPPPPPPPPSEPPPAPSEPPPPPPPASCAPPLPPSSPPPPPPSFAPPPLPSSSSVPLPPSSPPPLPPDVPPPIPSTSAVRLPPTGPRRDPFTGVYSAQPHGRLPIHIPTGPRAHRGPSPPIPQPPSEPPPPRPPSPQLYSLPPPPPWPPEPSEFPPGKNWKVLFDYAIDKDREGQYRALAEKLREKGMDQGDEPRVRGKGKGKEIILRYGGEVIEGEHEAVVRDPRKEAKTKRLPSLRPVRTELVQCKYEFDVNSTGPLPPTNVLVQGISPLIPKHHLRQRFGMHGTVLSFEPQLDKSSGLFLGIVFIKYASHEEAKKCVAAENRKKLNIAVPGLGEGEGEELRVVFDGEGKVLKAVMGELDRRAREKQRREKEEKEKHLKPTPTSSASQTPVHANNPWRTTLRDGGPHNNQRQLGQHNVPRSLPPNAHLPMRPQGLTPMSMVGSPADHGKASPLPNGTPTGPRNGPARVRRPAPPTAPFRARHNVHVLRAVPPANIRPPIHLFPNGIEAGPVLPPQFGPNAVDTPSPVPFMPSRSPSPVSRRPQFGRGKKKIDYDVIKAELAKNGFDHIAIDGHVTSVEERDVGIFMVGFVFDKILRDRHSWYVTFKDRETAHRAMMVITGMGRKLAHHAVTVTVRPAPTHIPTAHKTEWTDGELLEQAEKQLRQELRTRLEKDIIERIVASQVRRRVVEERAKQGVRVEAVIDGHAADTVDHESKYLDRDALRGLSFRTKKKRPREEAVAPVEAAIVAEEEVVMERPKKKLKKSKKVIVEEKVVESEDEQEVAAVDVPEPTKQRKRAMSEASEVEIPVKKKAKSQQVQVFENDVVPVRTKKSKKTAVSEVVPDVKDTSVFEEEVVHEVLPETLPFEPPAVDQVHVTTPFVLTPSPLPSPTVPASILLPPTAVIDPIAEGICEDEEDMYFAKLALERMLYGKSTGPEDELEPQAEPDIAALFRKHVTGSARTEGYYKISHTEKSAYVAQYALRGMTTTVATETEQAPPPKPAVASSRSNRANARRRAQGLEEINQVQRAMALSKGEAAAPDSVKYNQLQTRKKHLRFARSPIHDWGLYAMEKINRGDLVIEYVGEVIRAQVADKREKAYERQGIGSSYLFRIDEDLVVDATKKGNLGRLINHSCDPNCTAKIITISGEKKIVIYAKQDIELGSEITYDYHFPIEQDKIPCLCGSAKCRGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Q8</accession>
    <name>A0A2G8S7Q8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">GSI_08015</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Q8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7Q8"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="251"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="827"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PIL29809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="937" mass="104375" checksum="5ECE38114E679901" modified="2018-01-31" version="1">MYASFRRRVSMVLPTLKGKASTYGLSVVASVRLAATPTAVSRPVHRQFATFVTNTHLRTRSRYGVQPLNVRRVHVRALSYSSIPRLVLRAFRVPVGAATVGAGGFTYANYKFEEFKKKSNEVFSTVQDTITDAVDAASGLAKTVKSRVSEIKLPDIEAPGFLKSMFSSSSEDGNGERQEGSESSSRKKRPSGDDPAALAAIMAATSLSASDSKAGDSDGLNGDDRQNGLMHLTKKLIEIRTMLISIDQSDALKLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGNNMVTRRPIELTLINTPASADGKASQEYGEFPGLGLGKITDFSVVQRTLTDLNLAVPASECVSNEPIDLRIYSPHVPDLTLIDLPGYIQIASMDQPETLKEKIAGLCERYIREPNIILAVCAADVDLANSPALRASRKVDPLGLRTIGVITKMDLVPPDQGATILSGNRYPLHLGYVGVVAKGSGKKAGRDTRGALVKRSEDEYFGSHRDYFGAPSKLMVGTNTLRRRLMEVLESSMASSLHGITNAVQLELEEAQYQFKVQYNDRRISAESYVAETMDLLKGRFKEYTAQFRKPQVRANLKSMLEERVMDVLEQLYWTDKRASELTQLGADARVKLEDVEPYWRYKLEAASSLLTKSGVGRDSTLLVADGLRALIDSIAQAEPFNHHPQAAERLIQFSHAILRERIGMTSDQVENCIKPYKFEVEVDPREWELGRTGAVALFERELKALEDRLKDIRTRVGGSRRLNNLMGYVRELEEKERERKLKRLHGAEGDEAVAETADDYRYPPAQLVDGRHAMFFNDRIGILKLRLAALKSRRCKAGPESDALCPEAFLNVVADKLAYTSAMFINIELLDHFFYQFPREIDSRLLYDLDRKEIVDFARENPIIRKHLDLQERKDKLEEVMKQLNSLATLRPDVQPTPRRQRGLFGSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Z9</accession>
    <name>A0A2G8S7Z9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5648 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Z9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7Z9"/>
    <dbReference type="OrthoDB" id="9971254at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043708">
        <property type="entry name" value="DUF5648"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18885">
        <property type="entry name" value="DUF5648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013775663" description="DUF5648 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5648" evidence="2">
        <location>
            <begin position="42"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="181" mass="19346" checksum="1A967E4671348971" modified="2018-01-31" version="1">MKSFFALVAASAFFLQAHAHPVAAPAIEDRATAACGSSTVALLRAYSSSATDHFYTTNAVELENAVNNLNYRSEGDAAQVFSTQVSGTVPLYRLYSSIGGDHFYTTSASERDNAIAEDAYRDEGVAAYVYPSSQCGAVPLYRMDNPAVTDHFYTTNVAERNNAIANLGYVDEGIAAYVIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9C9</accession>
    <name>A0A2G8S9C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9C9"/>
    <dbReference type="OrthoDB" id="3207336at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="179" mass="19107" checksum="061E50EE762529A7" modified="2018-01-31" version="1">MATTSAARRHACTNDLGPVVCEQCQLAQDRSVGRWTCSSRSTVSSRMERTASWSPGVTWSMDSCLRTLSDYILQSFGFLDGISLPAVKDFDTKHIPGQETVTQGVVLCGRENDVDADTNKPFAHPASPYLPASPDGADIAMVNATFAELGALSGISLQEHDWIVSVLNLGGATSLAEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9X4</accession>
    <name>A0A2G8S9X4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9X4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9X4"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="75089" checksum="968B748EC5877FC8" modified="2018-01-31" version="1">MAAPPPEAKNALPPTILSILQQFASQDILTSGGLHPFASSPEDTVSTLRRLVDATNQAALSLNAHLSLPLNNPKLLSLYRQQASIAFSVQQSEQNVRHVVNSLRKRVGIMFGEDIPLERSLLVEWFLKRLLEWGTSVGMETFNDPEQNGRTSVVLGGKVLVVDIDFAIDRTDPTKPTIDVATLKTAYAIPNSTAESSSGNSVSLDGFLAHAIRAFLGEVQKEDAQRDSVEAARIGNLLSDHLSYLMKLDHLALSEGDGGLRWFSFIDKMSLEVEKFASREAAAIQRSERGAATAPLDVFLLRGHALPLPYLTSPSISFLTYISPLAYLKLLRTSRPTAPPPSHLPALDVPFPHLRAALTTHPRPSGATVATLVLSPNPPPAYHADSMSMPALDARTATTLVEDADRLEVVFPAAREVPGQQQFSWVLDFTGGGKYPGVVVSQARMREIELVVNPFSGMDQMGDVPMMAFGTGSWVDLLFNSQVPISPERYTSVYTSPTSVHPPLQLRLSTPDEPGFVLETIPVRTLKEVWNILEIVREQCWLNEILTSCQWVPEGLGVNPARVPYASENTTVTDDDLQAVLKGSVKPRSIPVNVHIPTPVPPFADADVDMDTFSLGRGHARITMTAPERPPISGLVEIGVTFDPIKERGVAVDITGAVGVDLNTEVLEEACRRGGLLGLPGRVWRKAHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA10</accession>
    <name>A0A2G8SA10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA10"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA10"/>
    <dbReference type="OrthoDB" id="2734661at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="291" mass="33041" checksum="213528C09FF53065" modified="2018-01-31" version="1">MYCSKECQKNDWAHHKAMCKYITRRDRENWGKDRLDTEGQLVGFKDATELSDALSDWIDTNHWAVGIYAKAHALREGGLRDSGLKFTQNPPKVLVIGLLCLPGARALPPGRGFRVIGHDWITVERYKSGSAIDLENWNHTLPTQRSMRERFGDNSLFAGLLPVRFEVLGTIISMLSFFPQRHPSPVIMETDFDVEDMRIAIDDAVRLSEGSMNAGLAFRCIDPHNTHVALPGKFVRSNKRWAWEPAFPDWEGYMEGKYDPPGFDSLKLKSLISSLKSEANMLQLLVMFEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA57</accession>
    <name>A0A2G8SA57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_07177</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA57"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA57"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL30478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="257" mass="28799" checksum="9F127802066B1B1B" modified="2018-01-31" version="1">MMVSATFADRPLKKLVLFDVDGTLTPARQSVSPEMTALLRALRKKVAIGVVGGSDFVKVSEQLTVSGSKVTDDFDFTFAENGLTAYKLGNQLPSQSFIKFIGEDRYKALANFILHYLADIDLPIKRGTFIEFRNGMINVSPIGRNASVQERNEFEAYDKQHGIRAAFVTALKEKFPDYGLTYSIGGQISFDVFPNGWDKTFCLQHVADEQFEEIHFFGDKTYKGGNDYEIYSDARTIGHSVKSPADTMQILKELFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA67</accession>
    <name>A0A2G8SA67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_07188</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for methylating the 5'-cap structure of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA67"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA67"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="13">
        <location>
            <begin position="503"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="455"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="365"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL30488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="790" mass="84462" checksum="4F1FC9DD4485845B" modified="2018-01-31" version="1">MPAFDPVRDAVLNSPITSSHPLPSSARMHVDTTAQPKPSFPSGSFHHSQPLSGRAGMSIVTPTAPGSAKSFSSDSSPGAALVSPLTRRATDLSVLLNSDPIDTPLFTPTTPRGPATLSHLLLPDSDNADNERLSHMTPLRRKSSATMSDAPVGAARELSYFTHPGSTYTRPLSSSSFPLPPNVPSEVTDKPSARGREPVGLALPGTVTPIVASTTSILAFPSSSGSRPSPVIPFSSGAGPASRSSAVAQPLTSSSVGASTSTPSMAPPIQAPSRSPVVSTSSLPPASTSSSMAPPPQRVPRPASPSKPLHSTSAVHPPPPPPISASSTPPLTTPPPSQSAPSAAQPPQKPSPPQQRKSIGNGAPAKPPAPAPSLPPPSSSLPPPSSSLPPKPMPPPSPPSSQPRRSAIPYAPRRITPAGSVLVPLSPAEMERYRNYTGGAGTMILRKQKRVENLLGDGLGKRERSPEAPEENPRKKRRSGDVAVVVEHYNARPDVGVAQRQESPIIGLKSFNNWVKSVLITKFAHPAFATSPNGRKGRGMRGRVLDMGCGKGGDLTKWAKANVAELVGLDIAAVSIEQAQARHVSSKGARFTASFFALDCYTRVLSDALPPNLLSTPFDVVSMQFCMHYAFESETKARTMLRNVSTWLRPGGIFIGTIPDAKMLIDQLDALPANSKDLSFGNSVYKIRFEDRENRPIFGHRYWFYLQDAVDDVPEYVVHWDNFVQLASEYGLHPIYKQEFHQVFEEFHEQPEFAPLLQRMHVVDANGESQMDEDQWEAANVYVGFAFEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA74</accession>
    <name>A0A2G8SA74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA74"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA74"/>
    <dbReference type="OrthoDB" id="2497589at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="202" mass="21059" checksum="4168FB8A6D7D59E1" modified="2018-01-31" version="1">MPPKKRAAEEEGAGPTTRSAKAPKTEKVEPSSKVGKGRGGKKGLKANLAASAFKARALPMHINITHTAPDEATTSGASADPGFIGTSTLVPSTFATGSYGWKGSKRFTVELPNPESTEGEDKEKVHVMLTINATVIGSKGAKEDGEGAEGEAGEEHAEEGAEHAEAKEAAEAEESLKESKEPKETNGDPKDDDAMEETKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAY2</accession>
    <name>A0A2G8SAY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAY2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAY2"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1218" mass="133319" checksum="2377BDE1F577B053" modified="2018-01-31" version="1">MTKTYIMNGLVEKMQSPDQDFRYMGLNDLLVEIKQDPNSFLGDETTETKVLRQVLALVEDKISEVKNQAVKCLGQLIKIIRESQMEFVVDKLIDFSAGKDEELRDISGLALKTITSELPPEGKIATKACEKLTPKLLGQVANSDTPPETLIETLAILSILVTRFPAYLSNVEPQPVTVLTPVLIHSRPAVRKRAITTLAQFLPHAQPQEFSTLLSSVLVPGLAPSANIEKQRTVVQLVAAIARHSPHLIASTLSDVTQSILKDSQRDDEELRESCLQALEALVLRCPSEITPFLGSIIQVGNQYIKYDPNYAGDEDDDEDMADDEDEDDEDLGDEYSDDEDTSYKIRRSATKLLAAVVATRPELLTTLYKEVSPVLISRFGDREETVRLEVWSTYGILLNQTGVYGGTPQSNAEYTVGGKRKRDEGMEVEETPYTLLQSQVPSLAKALLGQIKPPKTAPATLEAGFSLLHKLLTVLPGCLASQSAQIISSAKAVLSASSRANSATLQVTCMSFLTLFFSKHAPPVYAGQLDAISPLLLQALGEKHPRIASEAFRNFSALLVAMQPVKGGAWVDRVYDEAVKRLSNHDTDADVRAGAEEVIGDLWVSATDVLRTKNRKEWEFICRTTGRTDGAVRVVTKVATKVQIGDDWVNGGVEWVTVLLKKSGRTGKIEVFNCLDALIRRYTTIPADLPANLIPPLKPYFNASDISLLGAALNIVALLLELSPATTFAEVERDVLPDVYGIAHSPLLSGAPFDALLEFLGALVQADMQIATHVVPNLVVAVERAPKAEASLTNVAKCVGQVVNSQRGVAAGTIAEFGRHLKPSAKGKTPQVVLSLLVMGEVGRFVDMSPQQEVFNQAIEKFTAEQEEVRTAAAFAAGNISVGNLHHFLPLIVKMVEHDQERRLLSLHALKEIVTHCSHGQLETVADQLWTPLFENSENTEETTRNVAAACLGKLTTTHPTRYLPQLHGRINDPNPATRATVLLAIRYTFAETGNSFDEILSGVILDFLALLSDADLTVRRLALSALNSAARSRPHLIRDHLTTLLPSLYKETVVNPDLIRTVQMGPWTHKVDDGLEARKTAYETLYTLLDTCLSKLDLHEFLGRVASGLADDSDEVKVICHMMLFRLAQVAPTAVAQRLDDLTPPLEKSMKGPAVTKDTVKQDLERTAELQRSTLRAVAALSKISQAGASPKFDAFVATTQKSPEWGHEFRELVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB48</accession>
    <name>A0A2G8SB48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL30980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB48"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB48"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="554" mass="57413" checksum="3024E3ECE62E55E0" modified="2018-01-31" version="1">MNSFINSVANQMGKGRSTKPGKSGPNEGVGLNSPIDGAGGKSKPPADSEATKPITPGPHPPSPPESPKQRRISLSSRLTNLNTYAGASSTGATGAPTSSTAGPSIRDPTAVAVADLLGTMQNTLKALGNTFDVLGEQTIRVASLGPAVDALTQIESVQVELSKRTEGQDQDMQEVKTRQLETVKDHLRTVFRPRVNEIVAACVQKEIETRLTEQIPASLRDWLLRYRLQIMEAKRNLHNSEARRHNALIRSSGLDEPLKPLLRPLQFPVGPDASADTDGTPEAPGENDKGKQDKKNKVNGDGKDKGKDKLKDKSKPADKGPGMPTPPSTAASVASATTSRTARTGAAANRLSVNTAVSASTSIAAVTALQSPGSALGAGVTVDLAALGRWDAVPATASPGFPHTLAAVVSLTAEHARALVREYGLVSAEDEDDEDDKDENVNPAPVRGGKAVRGGPQGENASGRPGGVRGGGPASGQGGKAQRPASMATACSDASSWANAGLAGTREDDINKFMRYIGVGFQVLPATPIAIGGGTSGGLVSSPLVERRDCAFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD38</accession>
    <name>A0A2G8SD38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD38"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD38"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="112"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="323"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="525" mass="57836" checksum="CCD505CC8720448B" modified="2018-01-31" version="1">MESRATQRRNEYKSKGGLKQDELRRRREEQQVEIRRQKREENISKRRNFLPSAGPDSEDEGGVGTWESPLADEMITGVFSDEADRQLDATTKFRKLLSKEKNPPIERVIECGVVPRFVEFLRGDNAMLQFEAAWALTNIASGTAEHTQVVINAQAVPEFIKLLSSPVPDVREQAVWALGNIAGDSPTCRDYVLQQGALRPLLNLLSENNKLSMLRNATWTLSNFCRGKSPQPDWDLISPALPVLTKLIYSLDDEILIDACWAISYLSDGSNDKIQAVIESGVCRRLVDLLMHPSTSVQTPALRSVGNIVTGDDLQTQVVITSGALPALLSLLSSPKDGIRKEACWTISNITAGSPQQIQAVIEANIVPPLINILQNADFKTKKEACWAISNATSGGLQEPSQIRYLVSQGCIKPLCDLLQMMDNKIIQVALDGLDNILKVGEMDKQAQGPGGVNQYAIFVEEAGGMVTIHNLQQHDNLEIYKKAFNIMDKYFPDDEEAEPAVDGTSFQFNADGAAPPPGGFSFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE01</accession>
    <name>A0A2G8SE01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TECPR1-like DysF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE01"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE01"/>
    <dbReference type="OrthoDB" id="72441at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TECPR1-like DysF" evidence="2">
        <location>
            <begin position="100"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="462" mass="51695" checksum="BF2BDDAA183CC8B4" modified="2018-01-31" version="1">MSDSVSSFASSPAGPSSLPHTQSLSPPLPDALERDDYAAADQARERLNKRGLLSSVSLQLPHLHRSRTKSQDSSIRLSYIQGEAEDSTSETTAALNLVNLVENVSVEDDENYDKDVYRWAVLYENQRGAMVFSTAYYSPLTLLPLDPPPFTIPTATRSPRKNQPTVTLEDYPLPDGSWKWVSRAWMIDMRGDGEVQYDGFEYARSFRSKKWGPDTGFMSNHGLVRRRRWIRLMMRPAQAIHDTESLLEHTGNVSVVPEMEHREEGATRPPSVMFSVSDDSEESGVWRGDEDDWRRCHSALRHLSRDGRKLEVWAHWLGVSEKPVVAPCRSPLLPAVSPFLVPLRRAAESGEWEKQVPSSNPSTEDVASTSSSKRRGDKITLDVGVRLTQAPKEHVATVIRCHASDILDLFVYPESRAKYLALLGRVGLLPELRAGLGASDSVQVLDFWSYTKDFGNMDSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE94</accession>
    <name>A0A2G8SE94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE94"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE94"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="101226" checksum="CB45C5F7F224CECD" modified="2018-01-31" version="1">MPATVLPPRRTVPRPVPRDRREEERAPTPPPPPSPIREISPTFSILDGHEADGSFSGATPSCVKLARANVETLDWDQIRRILAPHHRRTHHSPRNARGSEAQVRPPSRRTDPTGLFELLTQPYVELPPPPPTPKPCIRPSIGPPSHTPNHPRPRRLPEYDVDEDELPDPDADLPEQIHYEIAYVPNGKYAWAAGQPASKLRVLTHLHSALTDGDQWSTDLMFGVIGGRPTTFMSKSWSRLQAQTRFLPEFKLLSSDSYLRPLQGLVVPYVINLYDTQDTIQLFMEAPHQSFWVEASPTMSDALKQRVVDAYRKLHGTGVLHASVEKKNILIGGDGRVTLVDFSMARTKRPIKEIGLEGCTDKDLALELRKVKFILDYGHARSHETQGAEKGDRHAPKPEVWHQWTLELGQPSKRWLVPGQTQEQYAEAVSAFRADVSRLELRRAVESVSPLLVLTPESPLPVRNRLPSHVTPSMSPRKRKISHVTADTATPAKRPRVCDKEPERPVCSGPLWKYTTTSYTAGTSDLLTASESPAEAAAPPAVKVRDFASQPYDGPRGYYVPHPPTELIMSSYRAADIRNTNAIRCGRLGLPYWRGDADDDSLAPPGYIRPLPKGQGLKISLGALKRQWESVEPREEIRSAKRTRLDLAGPLNFSESWETFLEQDTRIRFDDRVSFCDPWTYQEAASEVGGNTQGQGQYDEIKDQRCTAPLSHPRHRGTPKPTRPILKVTSALRTVAWDLNAWPHPSDEEILTTPLMEQCGLLPPPGAVPSLSLPRASVPTHGTSPPPDPRTTALDLAPSLDAPADATGVVNADSEAQVFPLTPLLPCQTEWVGSAHRRALAVELQPELTPEEMEDFEAWQVETLLEPGWDPALSPQANLLAIANSEGATPYRMDTDVCRWLRLGQGTRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEA7</accession>
    <name>A0A2G8SEA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEA7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEA7"/>
    <dbReference type="OrthoDB" id="5598396at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF4">
        <property type="entry name" value="DNA ADENINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28991" checksum="C2B154AE79691217" modified="2018-01-31" version="1">MRLYSKPSKRKRALASDDLQLVITAMASSPDHDDKLFLAQLLTGFHGLLRLGELVWPDSVKLRTSRKLSLRTTVQTTPSTFSFLLHSHKSDKFFDGDRVLIDRKLSSSPPLDAFASYLASRDSRFPFHPQLWLRANGTSPTRRWFITRLKSFFPDDVSGHSMRSGGATALAIAGVPSPSIQAIGRWSSDAWQVYIRKHPVLVHASMLAEQLTHAPPSYTRTLCGNSLQIHTSINLFLVSPSLDSFLSILSFSLPPLPISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEW9</accession>
    <name>A0A2G8SEW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEW9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEW9"/>
    <dbReference type="OrthoDB" id="2729552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053134">
        <property type="entry name" value="RNA-dir_DNA_polymerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559:SF444">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24559">
        <property type="entry name" value="TRANSPOSON TY3-I GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="285"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="496" mass="57095" checksum="64835E65657F6EEB" modified="2018-01-31" version="1">MIDSGATSLFASKRFVRKHNVFKHPLGREIPLYNIDGLHNRAGGITHFVRLQVVMGDYAEWREFLVTDLGPEDIILGLPWLRSVNPEIDWTGGGMRVETEEEETARGSTSGARRPKVTVEDCDEAEEEGVQAKREGDEKEETVTGADREKTEDESGRAESEEEERPMAEHVRANRAQRRKWWKAGVLEDATEELWCAAGYTYSIELAEKANKEKRQRTFEEIVPEEYRAYAKVFSEGESERLPEHKPCDHAIDLKPDAPKTIRSKVYPMPVNEQEELDRFLDENLRKGYIVPSKSPIASPVFFIKKKDGKLRLVQDYRKLNDVTVKNRYPLPLASDIINRLRQAKYFTKFDVRWGYHNVRIKEGDEWKAAFTTNRGLFEPCVMLFGLTNSPATFQALMNSIFADLIAAGTVAVYLDDILIFTNTLDEHRWVTHEVLKRLQAHDLYLRPEKCEFERTEIEYLGLIIRQGQVGMDPVKIKAVTSWPTPKNLRVLRPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFR5</accession>
    <name>A0A2G8SFR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFR5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="97" mass="10840" checksum="33CE4C78EC471389" modified="2018-01-31" version="1">MQACMQEDVDERMVEDLLGGPLSPESSFSAGNQSMDIDPIVMNSVEFKVSDLALDKEELGVVTMLLEDLDFKDMSDYKGKDKVVPPPREELFLPFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFX1</accession>
    <name>A0A2G8SFX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="9">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="9">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEF1</name>
        <name evidence="11" type="ORF">GSI_05379</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFX1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFX1"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000029">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="70"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL32675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="780" mass="86815" checksum="5A001D733A0B38BE" modified="2018-01-31" version="1">MLHSSIFQACLRTRPHAWLSPALPSRLWSLPARRNAATVAALKSSESPDQPLVKEYPTYDLTDDDIKRLRFQRNIGVSAHIDSGKTTLTERILYYTGRIREIHEVRGRDNVGAKMDSMELEREKGITIQSAATFCDWEATMPATGDKEKYAVNIIDTPGHVDFTIEVERALRVLDGAILVLCAVAGVQSQTTTVDRQMRRYNVPRISFINKMDRPGANPWRVINQIRQKLKIGAAAVQVPIGVEDDLRGVVDLVRWKAIYNEGEKGNKIVESDEIPAEVLPLAKEKRRELIEQLAEVDEEMGDLLIMEEDPTTEQLAHAIRRATISLKFSPVFLGSAIKNTAVQPMLDGVCAYLPTPSESKVTAHDTSLPVSAPQVELTPASVAPLVALAFKLEEGRFGQLTYMRVYQGTMRKGQFIYHARTGKKVKVPRLVRMHSNEMEDIQEIGPGEICAIFGIDCASGDTFTDGTSSFSMSPKTSMYVPEPVISLALKPVGQETPNFSRALNRFQKEDPTFRVHIDKESKETIISGMGELHLEIYVERMKREYNVECTTGKPRVAFRETITQRADFFYTHKKQSGGAGQYARVIGFVEPMEMNEETGKDIEFVNQVMGGNIPSNYIPACEKGFYEALEKGSLSGNPVCGARLVLNDGLAHSVDSSELAFRLATIGAFREVYNAARPIILEPIMTVEVVAPSEFQSAVIGGLNQRRGTIVDSEVREDEFTATAEVALNDMFGYSSHLRGVTQGKGEFSMEYKTHQPVLPQVQAELEMAYKKSIGQIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFY2</accession>
    <name>A0A2G8SFY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="20">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">GSI_05367</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="25">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="20"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SFY2"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000011">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000036">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 27" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 27" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="29">
        <location>
            <begin position="609"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="29">
        <location>
            <begin position="1156"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="30">
        <location>
            <begin position="1413"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="PIL32663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2267" mass="248113" checksum="591C3B87D47247D1" modified="2018-01-31" version="1">MALSNPALKINAVRPVLARSATNYRHGVPAPPIAATLVEDHDTLLDAVLELADGTVFRGIGFGTEGKSVAGECVFQTGMVGYTESLTDPSYEGQILILTYPLIGNYGVPPRPGESSLPDIPQEFESSRVHISALVVGSYSEDYSHFLAGSSLGQWLKESGVPAIFGVDTRALTKKMRENGSMLAKVLARRTDALLTPRDVFLSPSTPASRAPSPPGATPNGAPARWREDYLDIPFSDPNQKNLVSIVSTKTPRIFRPVGQPKLHPSGSRPLRVLAVDVGMKYNQIRCFTHRGVELKVVPWDHDYLATAEEPFDGLFISNGPGDPTMVAPVIERLARAMEKGDRPIFGICLGHQLLALAAGAKTSKMKYGNRGHNIPCTDALSGRCYITSQNHGYQVEAASLPDGWKELFQNANDGSNEGIYCVDKPFFSVQFHPESTPGPRDTEFLFDVFIQNIVDCAKTGGLVPISMPGGTKEENEARVPRAAVQKVLILGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILVNPNIATIATSRGLADKVYFLPVTPEFVRKIIKYEKPDGVYVTFGGQTALNVGVKLKDEFESLGCKVLGTPIDTIIITEDRQLFASAMEEIGERCAQSSTATTVDEAIAAASNIGYPVIVRAAYALGGLGSGFAQDEQQLKALCSKAFATSPQVLVEKSMKGWKEIEYEVVRDCRDNCITVCNMEASSLTSSPPARMNFDPLGIHTGDSIVVAPSQTLSDADYNMLRTTAINVIRHLGVVGECNIQYALNPTSREYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLGIPLNEIKNSVTKVTSACFEPSLDYVVVKIPRWDLKKFNRVSRLLSSSMKSVGEVMSIGRSFQETIQKAIRAIDDQFSGFAKNDFVEDIDQELMNPTDKRIFAIAAAFHRGYSVEKIWQMTNIDRWFLTKLQSIFKMEQLLYQTTVNSIDKDILRQSKQLGFSDRQIATCMGTTELAVRRLRQENGVAPFVKQIDTVAAEFPAFTNYLYTTYNAVEHDVTFDDCGVMVLGSGVYRIGSSVEFDWCAVRAIRTLRDQGLPTVMVNYNPETVSTDYDEADRLYFENISLETILDIYDTERSRGVILSMGGQTPNNIALPLYRQNVKIYGTSPEMIDTAENRFKFSRLLDEIGVDQPLWKELSSFEEAHTFCDKVGYPVLVRPSYVLSGAAMNVVFSQDDLSSYLSQATAVSREHPVVITKYIEGAKEIEMDAVAKDGKVIMHYISEHVENAGVHSGDATLIHPPQDLDPETVRRIEDATFKIGNALNVTGPFNIQFIAKNNEIKVIECNLRAARSFPFVSKVTGIDAIEMATKVMLSMPVEPYPHIPLPPDYVGVKVPQFSFSRLSGADPVLGVEMASTGEVACFGKDKYEAYIKALVSTGIVLPKKNILFSIGSFKEKLEILPSVQKLHATGYNIFGTSGTADFFTEHHIPCKYLEILGEDSDQKSEYSLTQHLANNLIDMYINLPSKNHYRRPASYASKGYRTRRMAVDFAVPLITNVKIAKLLFEALVRKMPLEVSPVDFKTSHDTHTFPGLVNISAFVPHLTMAGGEFAEATKASISGGLVTSLILPVGLEARITDRASLDKAGSNFAGSAYCNYAMSITATSANAGTLDEELEADVRSLFVPFRYGEPDSQITAAATHFASWPPEKPIVTDARGANLAPILLLADLHSKSLHVTNVQTKEDMLLISLSKGKKLKVTCDVSVYALFFSRDQFQGITCLPTVEDQQYLWDHLESIDAFSVGRVPFELASQLGKPASATSGIEETLPLLLSAVASGRLTLDDIRLRLHDNPLRIFALPDQGHTNVEIVVGRKYQFHKRKHAWSPLEGTAVNGAVHRVQVHGQTAFLDGVLSSGPLGKDISSATISHPALERRGSISGGKAEIPIGPGRSVPEISAQMHPTSIAMSPTALAPVHGPAASMQVFSHLLPHPAFNRRHILTVKQFGHRDVHDLFTLAHEMQLQVERSGTLDILKGKVLATLFYEPSTRTSSSFDTAMKRCGGEVVNVHVDSSSVLKGETLPDTIRTLGCYADGIVIRHPDVGSSQLAAKFSPVPILNAGDGIGEHPSQALLDVYTIRSELGTVNGRTITMLGDLKNGRTVHSLVTLLSLYSVRLNFVSPPSLAMPASVVSAARKAGIPVYQCESLEEVLGETDVLYVTRLQKERFKDESAFNAVKDAYRVDHALLSRAKEEMILMHPLPRVNEIDPDVDFDSRRAVYFRQMRYGLFIRMALLASVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG43</accession>
    <name>A0A2G8SG43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Acylphosphatase</fullName>
            <ecNumber evidence="2 5 6">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_04851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5 6">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5 6"/>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG43"/>
    <dbReference type="STRING" id="1077348.A0A2G8SG43"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF3">
        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="8">
        <location>
            <begin position="11"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL32736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="138" mass="14998" checksum="D17FD2640C19BD03" modified="2018-01-31" version="1">MHIPKAMALRTVDYRVKGKVQGVFFRVFARSTAQGLGVVGWVKNEPTGDVIGTAQGREEALEKFKEALKQGPKHAVVTGVEFSNEAPLERLQFQEFEKALAKQQAEAKVISSSQEEQNEIALAEAAQAALKGRSGQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGD0</accession>
    <name>A0A2G8SGD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05342</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGD0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGD0"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="59"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="452" mass="46970" checksum="BAC10586BC5D801A" modified="2018-01-31" version="1">MLLALNPTNKTGLIDTLRDISNPASPNYGQHLSKAQVESVVAPPQESVQAVTNWLARYNITPEVISPAGDILRIRVPVTTANALLSANYTTFAQEETGAIAYKTDVYSIPAAMQPHLAAVYPTTQPDFPSGTFKVQSVDGGITSGKGTLEASLDIQYTVGLATNVPTTFVSVGENNQDGSAFGFLDIINFFLAEDNPPLVLTTSFDFQETSVPPDVAQMLCFAYAQLGTRGTSILFASGDGGVAGQQASDTCPDGLFVPTFPSTCPFVTSVGSTEGVAPEVAGTFSAGGFSNIFPRPDYQASVALAYLDALNITANTNASSPSPLAGRFNTTGRAFPDVSMTGRDIAIIAAGVPQPVLGTSASAPMFASMVALVNDELLNAGMPPLGFLNPLLYSTGAAGVFNDITVGNNPGCGSDGFPALKGWDPLTGLGTPDFERLLAVAKASATFRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGN5</accession>
    <name>A0A2G8SGN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGN5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGN5"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="14226" checksum="26E0AEB4A9EE5F6F" modified="2018-01-31" version="1">MERIVKAQALRDSSMSSYMALKKTLDLNPHNPIVKKLKCKVTEDKVDKPVRDLIFSLFETALLISGFLLDDPTSFAKRIHRMIALGLDVDEEEAAAPLLSSCSVALQLYVSLVISSSVSTAYLLPAASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHI5</accession>
    <name>A0A2G8SHI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHI5"/>
    <dbReference type="OrthoDB" id="2756971at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="227" mass="25643" checksum="983DE19F7D4DC15F" modified="2018-01-31" version="1">MLSTTTITITAAALCSPDIVYAKWRGRTTNEPLQYGLPSYADYYDVTIRPELPLAVGRVVKIWALMETHRSPLDHPAHLIQYNTYDPRVEGRIIRVRSVEGNTVEFVLENHIKDSLAGLAYVTVPYLPNVTAKLDMLGRVFKWLTVRGNQLNARFVHLESAVVVRTVTEFSPCPAGKTGLVQELTECSDEQSDENLGTPKINAFRKEEWEEDVGRDWKDESECGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHS3</accession>
    <name>A0A2G8SHS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHS3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="90" mass="9939" checksum="E4AAB45126F30F61" modified="2018-01-31" version="1">MLDEHPARRFPLSRILANEAQANFISIASRGPRRVSLKPCSRQGSRQVSLLDPDASPTAAHRNTTDSGVHKHRRVCACALEPRSAWLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIG1</accession>
    <name>A0A2G8SIG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIG1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIG1"/>
    <dbReference type="OrthoDB" id="2593747at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28590" checksum="6E75C7F69A63A135" modified="2018-01-31" version="1">MAVPGAALQPDPVFFPMAEFQVEGFLFRVPLYIFQQSQFFRENVLAQSQREAAAEADAPYELQDTTAAEFRDLLRCILPMAGPFPSGATALTNVLKLATRWKFDFARRVAIRKIAYTVDSPALKLVLARAYAVPEFLPSALGGLVDAPALEVDDYEVLGRTESAEASSLELVAKVVKYRERARRARCERKEQKRESAAATDPDPAQRRRLVEEIFGAEFARDYRKGEEIIAARAMALTQPQPRPPPPPAHRSRPCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIX2</accession>
    <name>A0A2G8SIX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIX2"/>
    <dbReference type="OrthoDB" id="2803865at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="291" mass="32983" checksum="748416383012B3DC" modified="2018-01-31" version="1">MLPLEGRRIWKRKFTGATVVYLLNRYTALFRRIFFIMEALSWNRSDQRGLTHADDALLVLNYFAFAAFTVIRVYAVWGRDWKPLLVVIPLSLARPVLFMASSVLYVPVQGGPLAGYPLTTLPALRFEMISVATTVTSEGIFLALTWVRTYGIKKDWSRLGVHTPLTTLLLRDGTAYFVTLFPSKVLAIISDLNASPTLFLRVWPYFDEALTVCFLCRFMLDLRGVYFSDDLENELLERTAYLSNLRFSSSAVGNLDASLGGRLHHEGSDEDMSRGFDSLPSSLPYDDYDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ16</accession>
    <name>A0A2G8SJ16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_04389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SJ16"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1683"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="1756"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="962"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1495"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1564"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1957"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="964"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1568"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1962"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2014"/>
            <end position="2026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2026" mass="223516" checksum="537F50E7DB09004E" modified="2018-01-31" version="1">MSPANGGYGDLRSLSRRPWSKSADDLSKMSTNGSTPTLTPIDTSLHQKIKTYRSDSVSSSAATSSPIPSPSTASFKMKYPFPVVSAELSTSPPKNARLAPLPPSNYGPPISPPLTPSSSTSTTTSHVHSRSHSFTPRLPSKLSTPKVSGLMPPSPKRKGSASSERGDPDRDKSSTGSGTSGRSPFPFGFGGGSTPKIMPPPLTISSDGSHSSQGPSSPTFLAPPPLIVEPGPGGDDAGKRSSQMVHQSGFINRMSDFSPEMLGSRAHHAYMTGQSQAVLTKGWKPFKLVLKGSKLYFYKPPSDRGAGIRELFPTELVADIPDAEEDPDMSMGVDMQDSEMDMGGRGGGGKGKERDELRRRRAYWGRGTHPALVIVDGEVQKGSTEAIVHEAVFATTFVVPSPDGSGLGSDSSVRYKLEWREFASGIILCLPTLVGRAVFETEFCRCCTNLLGGAEDDVKEEELERVRWLASKYLNYHRSPANQETWDSWCKDTIPDFSPSASPIPNSVSQSLSTEPSQASLTGLGTEMHPRPHDSKMQSIIEALGETNLQPAPAPPPSLSPKSLRKALEDEGLSRDVLLNLDPALVARSLFLRQRPALQKILGNFAADYVLSVGSQEPGDPSPLRPFLGSDEQPHWLTRIVLIQVLVPEPAGAASSNHVNGQHPAASRAHSRSEVISAWAKVGEASRRAGDDCSWRAIMAALCSRPIARLDKVWKRVDPEALSAVQAWAHIVVRRDQSADVPTAPLVYPWAGDAERDVREALEKARCGEGEEWAVGCLRSVQERFDDLRTTFASCTQRCEADAAVSVSEAPAVDVLVKHWNTLTADTESRGLASKFLRVEQFMSLSNAAEPRRRGLFEPYFWSRISQQPSAHPLAALLFPDPLPTICFINRAQIVRGRLESNASLHAPFSAQDIRSLRLLADGDRTIRMDRPKLNGLDLGGTTIPVYNGELLLLVQPGGDPVISSRPTSRAPSRPPSRSTCDSPIVGRNPSIRVTPSSSHGHGTAERKSSLARRNSLPSLSQRTSLVASEITSERPLRVVVQAGTLERLVDVLVHGLQGVSVSVADDNGEMPLTDRKTREVRVDMDDFSQVWWSVFRSFVSTQVLFELLRKRYVGAQQPGRALTPDEISHVLRLRLEVLDTLNEWINLGGGAQDALDDGALYEAILAFLTQPTEWRLSGPAPEAEASASQAAKALEASRTALLTCFRSQTLRPVPRTPAIPEPTNDGASIQSYTSELPDLDQVGAEELVNNLNAMASATFRNVTQEDLFIIADLFELQSADRTGWYLNRDPSSIADEVEIQSMSSYVLEVEPSPLISELAQDNLYRLLPLSVRSCIRAFGILRKWLMSRIVASNLGIWARQQRMELMLRAIEVARLRNADSESTQVPLSERPCVRSFVEAIITSVVLSVESRTYQRAWLGVAIARGTGCDTLAAYFARPTVTSMSTRGTLTADMGWLMERVLEIISLPDVLESSPAEKTVLVNFEKRRSLQSLLANASGTGSARKQRRREADRREFERLSTIEKEVATIHFDLRAIREDAHREAMQASVSNSKRGHRPFQQLVAQQQEKNRRDRLMRDRLSKEKRQEQQRHDKREEQLNRAMNQRRQNPVMPKQHRNKKSMSSAFFQLMRPISSAFTSDSTPGGSPSKRTPAELDFVPSHKPSQVLSVVNAHVAHFVNNERSFVFQLNAEDGGHYLLQATSRQEMKKWIETIERVSKMTAKRRLTYLGGSVKLQMTDDLLARPAVATRDPVAVFGVELEFLLQREATGGDVQPGAIPSVVERLIDEVESRGLMEVGIYRIAGAHSEVNALRDALNRGEWPISEITDIHAVCDLIKSWFRVLPGGLFPPELYGRILGVTRREDVDFETKVSNVRDIVHALPAANFDILKRIIEHLEKVTDYEDSNQMTTESLSTVFAPNLLRSTNSDVGNFFSNMAACHRVTKILISHFHSIFDNDAEREQEAEAELEEPVEEPEEMEEMELEEPIPEEDEEDEEELFREADMPKLPSEPPILNINFSPASLTFNIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ50</accession>
    <name>A0A2G8SJ50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ50"/>
    <dbReference type="OrthoDB" id="2755172at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20873" checksum="368935684B7B85C9" modified="2018-01-31" version="1">MRLPVEVYESVVDQASDNAASLHHLSLTCTALLPRARHHLFSSIAIQTMEQMQASRDFLDAHPWLPPLVHKIALSISVSKSCSERNVHLLDVVPIHLLIRLPNLRAWSMGNNGFSFSGTAMPSLSLQRSVLQSYRSYGHSIHTLELSLVHFDAISDFTGLVSAFTGIRTLTCRNILFRKVEEKTTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJC6</accession>
    <name>A0A2G8SJC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJC6"/>
    <dbReference type="OrthoDB" id="2747824at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22661" checksum="0A30741979FFD520" modified="2018-01-31" version="1">MQMTEPGPAPSTFNLLQLPDDVQLSMLLAFDIRELIICKSRSSTLIPSPTKMCRSLAGLIDGDISIRYKIELARSGRIDGTPSVAVMVIDRLTSLREHSAKFHAGNHPLKHLRGRPFGSLGALSSNGYVTMVSAGMVHLCRPAATFSGVGEHKVTRSMWELQLEGFDTSDCAVDVAQDLLVYSRKDLNTMCVHLFDTLFALTVIEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJQ5</accession>
    <name>A0A2G8SJQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJQ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJQ5"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="52"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="394" mass="46186" checksum="8A2022D2028DA55F" modified="2018-01-31" version="1">MSDHDDEWDELEEENEPKDPNVFELDDCLAAPSARSYTTRELHALIHEGVIDLNPPYQREIVWPEAKQSKLLDSIWRNFYVPPVVFAVYTDDEGERVKCCVDGKQRLTSIQRFFDGQIPYVNPKTKKKWWYTISTARKQSKLEIPERYKEDFAEKIVTCVEYHGLPHVDERDIFQRVQMGVALTAAEKLQAIPSPWSEWIGELQSRYVYIDDSLTQKINVTIKRGQDFQLIAGIVYCCDKLSEQEQAMPSSNNLNVWLSREDPPPDTFKGAIRDLFNRFWNIANDDDLNMAFTEMKQRVAPAEFIFTGVLLYVLRDRSPQEQAQAIYDLRSGIRDKHHDIRTRGDIIRDLWMMIDELSEDVVEEVKPSKKSRKQRDDAMDLDDDYRPKKKGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJU4</accession>
    <name>A0A2G8SJU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJU4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJU4"/>
    <dbReference type="OrthoDB" id="2755057at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77732" checksum="966F6C00E0ED598C" modified="2018-01-31" version="1">MPPIFKLSRDPLAMICDYLLPAEVLSLYRSCKTIHGFLQLTSSKGIWKSARANVAGLPECPEWLTEPQYAALCFDDFCCQCLAVDKYSVSPIWPLYVRYCWHCRVAKFTTTPLRGFPVRDALGGFRSRPADLFPSVLAYVDEARQRTAVCYHVLDVEKFRTEVAALVQSNNDATVLAVTTAPVLAALEEKAANTAARLEFSRKCKTWKAQWIAQLKAAAKAVKLQRLQDILRKLEEQGYSAEVLELGPRHQGLSGDVLALVDQARPLTDRDWTAIRPMFTAFMEVRRDLGARVSFVRCLRSRLRLLRSTLFTYLHEDSRKAKRIDGARVFPTVLDLLDVRDAAYLVSLPDGAVLLPHLWVAQLPSFIEAWELGRTRILLSLLHGIEGGSPATGVTPYVSSAGDTTSSVTTRSTVPASSPLSHPAALFWCDGCMNLILGISAISHACCYGRAGPDAEEILSYLNPALNGRFSQALISSNTKDLLYSRTLIAFSEGVLPWSQEHLRGCVPIVRSVLEACGVNPHNLPKEMRKLSGCRVACRICCQVDKCVLAMGWLRAISHAFEVHGGQEGSWVRLCPKLEEKVKRIEYTSRDLFTADMETRTRWECSRCAWDRPHAGLSYTWPQLVDHFAVCHPMNHLSPIWYSPSNDTPPFMYPAVLLVERGMEGHFDEDLYDAFPRKHLVTPMRLSADTWAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK83</accession>
    <name>A0A2G8SK83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03873</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK83"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK83"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="219" mass="22639" checksum="120E13074252042B" modified="2018-01-31" version="1">MSLGPHVHPHLQTSFVAPPYSYPPTPPPEEVSLSQSAEFCHFAGPSGSAPRAIPEVNAQVRRATSVSTTGLATPPLTPDNGAEGGAGSLSALGAKQSAFLSTLFPRNGLRAAPYAKSVSISTPGTGFTFDGVVLSLPGKPKTFYVDGKCAATVNLRESIVALLDLADEQLGCNALVIALERSSAVLGDLLHSLMYVGGQVVTKPPFPTDPAFVLVGMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKV0</accession>
    <name>A0A2G8SKV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine cyclodeaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKV0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKV0"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="entry name" value="ornithine cyclodeaminase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="31668" checksum="FD0BBA43B8F0EFC6" modified="2018-01-31" version="1">MPSRVAPTGTTMKAVAVPTATAPQDVKERGLPASTIVVDERSGGVKAMVNARNLTALRNAAGSLLATRLLLPSNPGPETIVAFGAGAQIQAHLSVFLAAYPSIRSCTIFNRSLGPRVDKLCDLIGRSFPTVRITVAALSNDDKTTGVSLREEVGQADIIIAATSSTKPLFPSDYVRPGTHLCLIGSYKPEMHEIDTALVKRAGRVVVDQKSACLHEAGELIAAGCTETDLVELGQLYDYAGDQNRWTLRGDKTEDIRAAGDITIFKSVGVGVQDVVIACAVVQRAMEEGIGHVIEDYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKW5</accession>
    <name>A0A2G8SKW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKW5"/>
    <dbReference type="OrthoDB" id="5311491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="356" mass="38389" checksum="A9194A9F3C3DE620" modified="2018-01-31" version="1">MQSSTGFHIFLDSGPPGGSADYTTIVIIHGLGWHSGVFTKLIPLAHAHNARVVLVNRRDYRGAAPYSLAERTHLFTTAAEALTDGTAACPKVVSIMKEEAIDVSRLLTHFISDNRVPLARPHANSGGIVLVGWSLGTAWMTALLAHGAPRHANAVDLTEYVRRIVFYDPPHLALGFSPPEGVYFPFVNPAIPPEDLVEAFCVWVTGVVTHGETCTADTLDLGEPPASLPSTFRNLTAEERCSVVDPVPADPRGGSDTTLMNAALFSGAFAVLREEALRVRAPGDGLGGWDAVEVRHVWCDASPWPMPWAATCLREDVAGKRKAGGSVRDLAFTRLRGANHLAHWEEPGRVLQAFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL56</accession>
    <name>A0A2G8SL56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL56"/>
    <dbReference type="OrthoDB" id="2131701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23422">
        <property type="entry name" value="beta-trefoil_Ricin_MPL_CNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="139" mass="15794" checksum="F55A879432DBD0C3" modified="2018-01-31" version="1">MVESGRTYKLVNAKAGNVLDLSGSDNKSLIGYDWHDGDNQKWHLVQEDGAWVLRNVSTGHYLGVEGEACDGTPVVAVYEPFRWDIWPDEEDSSTYRLFVPNTRYNLDLSDHGNPTPGTPVTLWSKWHPGKNQTWRFEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLF5</accession>
    <name>A0A2G8SLF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03183</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLF5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLF5"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="52"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="608" mass="68827" checksum="C1D09986F42F2C3D" modified="2018-01-31" version="1">MDVKPLAQNLSPIQWVVSTFNFFYVLVQHLIIWLFKPHPPPSPELPQQVNGRIAIIGAGLTGVSSAAHAIAHGFDVVIYEQTDQVGGIWAHVNKTSGLQLNSLLYRFHPGVLWSCTFPKRDEILHETRRIWEEYQLAPRTRLNTRVTSVKRVEGTGKRLSDPSADEGARSRWLINDGADGAFDAVVVTVGTCGAPKRIDIPGLPRAEEDTSEEGGWREAKHRGGRAGEVFEGEVLHSSELDRADLEGRTVIVVGSGASGVEAVETALSKGAEHCVMLARDDKWIIPRNILMDTLIAAQPFGRQTPFSFLWEKLIVLLNYRDAPELVPARVGIFEGTPVVNDEFVDWVRQGKCEYVRCDIERLTRHGIRVSARSRDEKPGEGTETREYEGDVLVFATGFHKPEISFFEEDLFPDSYDRPNLYLQNFCTEDWSVLMTNSAYVNAIGTVGHFHIGIYMRILLTFLLDPDVRPTPKDMKLWVDVIRFLKRGARGGALSFFTYMELTIWLLLFHVVRIDRLKWVFFIMQGWGVYPEEFRRERIAQARMKASEVLEQAGRRFEQAQEWGAQAQRKAAEKVPLAREKVGYEVREKAGQAHQKASHAHQNIAQETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM39</accession>
    <name>A0A2G8SM39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM39"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="13369" checksum="6AA92AACFE503A8A" modified="2018-01-31" version="1">MEGHAPPNVKAALELAASLVMQQRDANLFINDNQLPSVQISANPVIRLQKTGGTTSHREQGRNYLHYNLSIPSVEVEYSIYVARASTRAEVNRETLARAIAYFIYNYDNGSTFTHEEAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMU9</accession>
    <name>A0A2G8SMU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione transferase</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMU9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMU9"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="66"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="21469" checksum="45C4BBFEC4049DF8" modified="2018-01-31" version="1">MVLTLYGNVHSTCTARVRTVLEELSILHEFVEIDFSKPEVLRSADVLAVQLFGQIPYIDDAGFKLFDQKTALFDQGASIEVSNFDPPASGLGFEIIVKQYIPGLETDPALVAKYKAQLERKLEGYESLLGRQKFVTGEELTIVDLFHLPWGAMLKRQGNDILESDKFPNVKRWWAEVSARPSWQKISAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNB9</accession>
    <name>A0A2G8SNB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="8">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01989</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNB9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNB9"/>
    <dbReference type="OrthoDB" id="2499463at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="69"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="281"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="473"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="645"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="795" mass="87456" checksum="4F24B638ECB1A362" modified="2018-01-31" version="1">MVHSDARQAKAAADYKRQQLGRKNLEEARRRRATTEAGYDSQATRKTMSDRFSSCTDGKKPYKWQLDVAEAFLLGLDCVVIAGTGAGKTIPYLLPLLLPESAKRTIPVISPLKALQRDQATRFRNLGVSAVPVNRDTWSKSLQEEIVNSSHRALFIGPEMCLQHAGARETLRAVGLADGFMGFVVDEAHCISQWGGDFRPDYSQLSVLRTFVPQRRAPIAAFSATMAPGVISEVEESLLINPATSFYLNLGNNRANIYLQVFALENSLDFAALDALLPLGTVSRAADVPKTIIFANSRRMTLRIWSYLCEKLRLPVAGRLPIAFLHAYRRQRARVRVMDAFVSGEVRILVATEAAGMGADIPDIEHAIHFGAPPSLTTWIQRAGRAGRSPRILARATLLIEKSAFQLINRKGPRKPKKQKTSTAESATTATEKGPEYRKKIDRSLRVWLDHKGCRREAVDEYFNNPILTARSVKRPRSSSSSAPSVLSPSKRRRDNIPMEEEESSGQIQVEVAPRRIRAGGHRERAIAALKSWRLEMVRTRYKLTSFSEEGLLSDDMIASLVYDATLKSVEDVIRKLADPPWVFAPRHAKDVLAVLASVDAAHDAAQASKVKPSALRGRSARSTALTKRVASENDENIHVDVELASPFSGSSPSSPQAPIPSDIPSSSTRAPKPRPRYRADQATSPQVPLTPQELLEYEDSLFIRRTQWGPTVASHASARATARASANSNEDYIMAGPSRSTSSMQDPSRAPTFALPSQPLVVVAPTVPPRPGSLSAVTHLPSSLSDTHPLFRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPM0</accession>
    <name>A0A2G8SPM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPM0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPM0"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="31796" checksum="87F2E3F6FCB6CEFD" modified="2018-01-31" version="1">MAPHASILLATRDNTSSDGSGLNPIIIAGIIVAAAIAVGLVIWLAIHWYRKRAAAKRNARRGSAFVNFRGVDNAGTTGEKAPLPSARNGLQMKGAFSRNQLNSNVVMPERAVLRPGASREEILEHYSSQGSLPRPFAPFQARGSADFATEPGLHPPSRPASGASWIPPSLSLGGSRDSRRMSAMSMSSSILSGASGGATQKKVRQLFDPVLPDELVVSLGETFMVVQSFDDGWCIVGRDSMFKPGEVELGAVPAWCFVKPVKGLRAERPMRVSSLGVTVDLGAAPSMGPRDNVMSWSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPW9</accession>
    <name>A0A2G8SPW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPW9"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="506" mass="57458" checksum="EBF6962A9CA9564C" modified="2018-01-31" version="1">MVKIGPRFYRRRSTPQSGSPSTPAPLKRALLVGINYTHADPKSEYGPLRRAQQDTKDFRALLISKYEYLPENIVVMLDQEGVAADLQPTRANILEQIRKLVKEGQIGSRFVFFYSGHSGQVPVDEQDPNKEEEEDGFDEFIVPVDHHEIRLNLTQDETGRVPYRREMESRMIIDNTLRRVLVEPLGLHIGVHLTAIFDSCHSGTLLDLDHYLCNNIYNPRTIQGYRRYKTLWQGVHRKDGQRMSQAGVKVITKKHAHPDNNAGPSSPLSREGSSCSVRIYQRRRVSETEMEVMDTSVGVSNTDDGRRRQFSVQSRRASVQVGRPPSLARVRESEIIAPRIDTLVEGSGILDGERCASPVSLKACNGFCEHEDNPLRSATVLSISSCQDAQRTWESKKGSFTQWLIAILRREPNLPISGFVRELTDKMYEHAQKTHQWSKKRKESWKRKHPEPEDSSTLADTESEVTHAEARAADELHPLDLYDYGDVPAPQLGGQCRLDLEQPMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQL5</accession>
    <name>A0A2G8SQL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQL5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQL5"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013849644" evidence="8">
        <location>
            <begin position="19"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="85"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="428"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL36061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="544" mass="55209" checksum="3F9484198B97E2E1" modified="2018-01-31" version="1">MVQYTLLSLLSLLAVAAASPRHIPPPLHIPLTRRSSHRNASIERFAAHADFLRLKYGYKTASALAKRAGETVGVNIIDQQADSSYIGQITVGTPAQSFKVVLDTGSSDLWVAGNQCSSCGSTPPFVPNQSSTIKEITDTSGKGQVITVQYGSGSVAGILAQDTVSLAGFTVNPQPFLVVEQMTSGLLQGDVSGIMGLAFQSLASTAATPFWEQLVNNGQFASPEISFWLARHLDDPTTVDETAGGVMTLGGQNSSLFTGDIEFNTLSNANAPSFWMLELSGATVQGKSVSVPTGSAAASAIDTGTTLIGAPSDAVTAIFNAIDGAQPLSGQLQGFWAFPCNTKLNVALAFGGKAWPISDEDMNLGRVQGNMCLGGIFDLNLGSNVGSGGGNPVWVVGDTFLKNVYTVFRASPPAVGFAQLSAAAGGTPASVSSASPSSPSSLVPGASSTHEKTSANPTLSSVHDGTSGTTSSATAIVSATFSASAGDPLPSLSSGASTVTVSSALNPTASAGNTAAARIASSQVLVGIALSLLASTVSGWVILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQT2</accession>
    <name>A0A2G8SQT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_01787</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQT2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQT2"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL36127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="523" mass="58253" checksum="26E22FFC4810A695" modified="2018-01-31" version="1">MSPLLPILTALVVAAGVFGLFHFLLPKPKRGAPLPGPKPLPFFGNLFHIPRELPWKVYRDWSLQYGDLVGLQLPGKQTLLILNSVEAAADLLDKRAAIYSDRPRSPIVDLIGWSWNTPLVPYGEEWRRTRRASWQHFTSKAMPKHHPTLLQESRRFLRLLHAEPDRLRELLGFSFAATTLKTMYGIDIAPGDQRFVPLLHAALEGPTEAFMQGSFLVEHIPLLRFVPAWVPGAGFQKKFARWRRLAAELLEKPFAEAKRSWTSGEGYHSASHEMLEAISQAQLSPAAAADEERVAKIGAANVYAAGSDTPLHVLNVRKTFSTLLSFFMAMAMHPEVQAKAQAELDAVVGLDRLPEHSDRDALPYINAVVKEALRWQNVVPLGVIHRLMADDEYRGHFLPEGTLVLPNIWGMLHNPEVYPNPEVFEPERYIKDGALNPDSPNPSSVVFGFGRRICLGKNLADASLFINVASILHTFNISVPLDDDGQPQKVDVKMSTGFLSYPSGFTCVIKPRSQTAEALILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR49</accession>
    <name>A0A2G8SR49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR49"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR49"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1072" mass="118463" checksum="F5445860E388D47B" modified="2018-01-31" version="1">MSALGNGQGSLHTLMMRSSTPASNEKVLLYLQGMDANPPEDDDGQSNVTTSEVVRSSRAKSKAASSVRQQSQLAAEENPAEDIRSDVQEHASELGRTIPIHTTGIPDHEPGPDDPPGPKFESYGSSFGNFGPLPRESFNGRNGIVSPSKAAAVPLPETTVAPASPTESHPNPFSQFGMAPAQTVGIAGAAASYAVAPSGVGSRSRHTSTKASHKAPSVAENGVASPKAASRALSPTRTGTVAGGTPERPWSPRTAASQNQSVKSRNTQKTQRTVYPPLPDSVLDDGQRTTKAYSIAPSESASQIGSRRLRQHQQLLEQQQREREEEQRERERELERERQREREREFERDRQSARTPSQKPSKSVKSTTEVNGHGGSGGTGYAKSQSAARSQAPMSPRSQATSVPRERSVAPTEGARSAAPPMSPARSKHTNHDADATPTPSRPASPENPLSVEEQRLVQSILDIPRTRTSYALSTMAPSALEPEVQNTHFHDMELCQLLHALDQPMGEPVKKAVRKAVRARVKKLGMKYDNESIKAYRKSFHDHDPVVHLIPALTGASSKRSALGGAPQDPPEWAKELLQGFINMQNRIDDLAPKIEKSLRSSRGGSYVTERGNYPNGHQHYETSEMNDGYTHSQMTQGIHQHPTGDESMYQAGEGEMIRDSTHLHTLPGSMHHHDGSMHGAIREEDIYEDEEGPHFAETDADTRGLDVEYGIQDRENSPGQQYLEQELYKLRLKPSAAQSVTTHKTWELARDDGAEYDEEDGDPQVAITESGLPEIPDGNTGVYTRGESPPLPPIPAERGDMLPIDHGQVWQPNDYSSEPRMLPPWQRIHQRLLNWAIVWPMSELDNAVNSCNRGMQVDEIALSIWSTQTYKRYVRAKMTDSPPGRVDRLFVPPNMADAISTAVYNGRHGDACGMLRDLWAPFGLEGIPRLLIVLAKHRNDDNHWVVHRFSLPDGSLTTYDTYPERCLPDGRPLGWWFAIRIAWPDAIYPSPDHLMQKMVRLHRPMQLPIENSVAAAGIWRNLLMGSRAERSLDLERLRDLISTEVKNLRQRKIMGKLSIGAPRPNWEDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRK8</accession>
    <name>A0A2G8SRK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_01869</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRK8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRK8"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000075">
        <property type="entry name" value="Sporulation-specific chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL36208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="371" mass="41736" checksum="82C24B4A6FF12364" modified="2018-01-31" version="1">MHRSHILYAFANVKSDSGEVVLSDPWADTDIHYPGDSWNDSGKNLYGNFKAIYKLKQQHRHLKVILSIGGWTYSPHFHPVVINPALRSKFVASSIRLLEDHGLDGLDIDYEYPSNDEQARGYVALLRELRAGLDAHASRKGANYRFLLTIAAPCGTDNYKKLHVREMDQSLDFWNMMAYDFAGSWDKVSGHQANLFGGQLSVSQAINWYIGQGVARDKIVVGMPLYGRSFMNTDGPGAPYHGLGPGSWEQGTYDYRALPLPGSYVFKDDKMVASWTYDYNKKEMISFDSEQVAAWKGDWIRREGLRGSMFWELSGDKGAPREGMEGGHGKDPQPGQSLIAIVKDTMGELDRSPNWLQYEGSQYDNMRAGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRQ7</accession>
    <name>A0A2G8SRQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRQ7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="113" mass="12525" checksum="76236E7A05FBE464" modified="2018-01-31" version="1">MLSGSTRSASRNGRTDSNITVASISSFIERRSVAGSRNSWRMRNSISGEKNDNRTSTRSAFRFADSVRSLSELATVPRWTSAVPARCQTRATRPPCISRLLDMLSQKCVRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS92</accession>
    <name>A0A2G8SS92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS92"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS92"/>
    <dbReference type="OrthoDB" id="2554293at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051222">
        <property type="entry name" value="PPR/CCM1_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942:SF15">
        <property type="entry name" value="OS12G0557800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47942">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT (TPR)-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="756" mass="85930" checksum="AF122D9BC5554D43" modified="2018-01-31" version="1">MTPKKQVDITSTILKLETGFVSEKCTRAALELLQTARTFGQQRTERMYRVLVDTLLLQGEIIVASLLFVILLQDWELRTLQDGGSRESAKDHITYGHLGVSPPHPYNILNTPYPDLRIMGKILETVKQSFGGLSDNEEAKSRLPYLQSLAFFAMLLDTGQLHTHRVAGVINALYSCPKTNAVVWILRDGEMVQVKAYQYFHDVLQRLIHSLSNRDSSRPPLNLSKRSYNSLLSYSLRHRFSPRMASQVLQHMCVDRTPPMAPDIVTFNILLRSGTLLRNLRISEAVLTALRLGSEEFNVENSPFRQPPLDTVGTDEACSSIDSSTDRPPEPIPDEDIPHSDFLAAKARLSREVFTPPNELLESVRTTATTLEPSIYTLTTFITHLTSTGRPDAVAAVLFDILPELNVIVADHPATNGSANLHSTMTYKAALKLAVSRGPYVYAAMINALVKAGEIGLAERVFILAQQAAIGSSNPNFVRHGRSWRLSVHAFTSLMQGYARVALGRLPAHKREREYVGTTLLARDALWRPQARHYDAGYARYVYAMREENFKIALRRYNKRQTSRRNATLLYRAMMTGARSILARFIAQCPTTVDSARVRTRRNGAIWWWRTTPDARFFNAALELFAAGSRTERSKRRPSRFWHGRWRRAERKFEQTGEVETDKWTPMLHKVAQAMVAHGFDVPVAYRHLLVGKWQTPMKAKRKRKIVIHAPYSFPPATIHQRRWTHSLPTVKTKGLPMRKRWRRRTKGEHIGRPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STR5</accession>
    <name>A0A2G8STR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_00814</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STR5"/>
    <dbReference type="STRING" id="1077348.A0A2G8STR5"/>
    <dbReference type="OrthoDB" id="3053196at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="12">
        <location>
            <begin position="170"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL37122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="414" mass="49238" checksum="0A542C59A6CC33E1" modified="2018-01-31" version="1">MSRPPKTKRKQLPHIQTFTDRIEDDPSHHLTGPFRPQTPLGQDSSSPGLRNLPTPWSTQSHGTWTDIKTLRWVVVPTSALKILLFFFVLWANWELLSPHVAKGVPNPFTPFLFISHRIPSSSDDDPRYQKGYLDFAFLAYYIVFWSFVRQAITIYLCRPIARWFGLKKEAKLDRFGEQGYAVIYFAFTASWGVRIMSQLPTWWYNTKYFWIDYPHWDMKPELKAYYLVQAAYWCQQLIVLLLGLEKPRKDYYELVAHHFVTLWLVGWSYLINLTFIGNAVYLSMDLPDSIFAFSKLFNYIQWDRAKVITFGCFVCIWSYFRHYLNWVILYSVWFEFDLMPETSKRWSPDDGVWMVWWMKYQIFTPLVLLQALNLFWYFLIWRVAARALSNLAITDVRSDDEDDGEEDVPNDKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUH4</accession>
    <name>A0A2G8SUH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUH4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUH4"/>
    <dbReference type="OrthoDB" id="3269050at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="89"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="38897" checksum="D09A4D156AD72E79" modified="2018-01-31" version="1">MTTEVSKDETLIFPEFIVGGELRLSLSNLGSSSPSERTALTCRIMKAFRPFTLSPVLLVWLDQSSTLPHDQAALPTTAILKLYDRRCLTNTREEFDEGAPWSLDKEHEYRQYLDDVASGAVPVGDFASQTFMWDNEVSDGEFEAYLQFQAQKSFNAERTAYERLEPLQGKKIPKLYGVIEHEITIHNARGDGFAVTEIIPGLLIEYISGPTLRQLVATWKARDPPLPNTVLTTLCEDAVKVVDRISDFDVLNEDVRIDNFLIREPFVDSSSAAIVEDAVVLIDLGQSRLRGEDESEDDWIKAKWSQDETGAVGFVTLGLVREFVGQDVWSYEKSLRYYRPLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUU7</accession>
    <name>A0A2G8SUU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUU7"/>
    <dbReference type="OrthoDB" id="5382203at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="772"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1137" mass="121044" checksum="7ECA68FD218149F3" modified="2018-01-31" version="1">MSVQCPTYISARSAEVILSDVRPIKLKPDALHAINVLLDEALYSILSTARSLATDRLKAALLKVLPTSLGKEALLEAEVELKAYWDRTGSVRSPLSPRHGETVVFDLQWSFELSWTCPRAREQLLRLKCEAYSTMNDSDEDAEAEKLLQHHMEAGGASSPPSPALLAPAALYLTAILEAICEYVIWPFIYRCMLTAARFCPCHRCPAAAAARHVLSNVSRVAARDSSRTLASVQDLFTALGEDNTIYGMFKAMKVFAHIEALSKTQSSRPRRSKSISRGTDKAIVSRTSSSSPLNGESTASHARTPSTSTVTGTVSGTASASGTARSRVSTESQKSTVVGSSESRGASLEKTQTKGSKIFHSRTPSDKLLHHDPANSALARSATENGINRENGLEFEFVTAAGVTEDDELQQEFDELMRSGATMKVSLTPDRLKSMEVYKQERFERERLSRRGTRGADKPQDGASLPESTSKLRGGKNGRSLRHVDSIVEDEEESGSSTHAPATPSHSSPPSSMRMRNMSFTATTTTVTTRPPSDQRLRSISISNVPHPRDKDGISRKASNATRDLLRQGSQNAAPPPTSASTNLGGIQKTRKKQVNLESMDLDDVLAGLDGDDVEDFVEVRAPVKTASPTDSPRSPGGSRISKNTQDLIAFLDAGPPEEPSLQPSANASVISFESSRARSGRLQRMMSRLTLGGSKESLNGSYKMSEETPKTPKTPLSLSRKNSKMGLVTSPPPAFKSASLQSKRSIPNVNGAAAYPSVIVATPPPRYVRPMPPPVSAASSTSTEDGLPSSNPPTLSRRNIRKAVPGIDDAVSPTSSAGHDSILESRPSSASVQVNGQGQGHRIARVYDDSKLPSPPAPAPAPVHHKTPIVNGHGHPVKLDTSESSLRVTSPDRKLSHIHAKAESGYASRSASRSPITPSQTQPPQPQPAGPTISLEIAEEMRKMLGTATSAEECRLVVDLFLVRSGFPLKEPASASASALAVVAGEGAGAGEGEEDGDGEGKGGADAAKKLEDAIAARSAADAEVERGLVALFLGGDDVDGLTSSRCSSSQSRSSAEQEQEQDQHTSSKSPDPAAPSASASPAPAPEPVAEPAPEREPKPERESEQERGPGLGPEALEQQQQQNFRNPSPVSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVH2</accession>
    <name>A0A2G8SVH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVH2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="282" mass="30596" checksum="4E5A023751FFE7E7" modified="2018-01-31" version="1">MELPLMLRMSGIPRFEEASEAELNRAIPDPAAVISDAPLGIPIPQLAAVKLVLGTRPGLGRRTRLRMLPARSWKFRFAANKTGTWTIKVLSPPSSAPLLPRFPSQFCRSLPAGPLSTVTDRVPGRLGPLLQPAPGLAEDVGSPARQRAVGYDSVHPRGVRVTFSSSTLPDRRTSTPSGIFGNMAMQPNLQNTHQRWALGRDHVRVPARLYSVHPRGLRAAFLSLTFPDSPTSAFSGMAMQPNLQNMHRRCPLGRDRVGVRVGSSLSNYAGVFGSNSRLATVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLB7</accession>
    <name>A0A2G8RLB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_15007</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLB7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLB7"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000728">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.4, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="989"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="379"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="556"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="610"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="652"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="743"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="831"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="846"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL22319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1043" mass="111204" checksum="1BD78840AEA9B983" modified="2018-01-31" version="1">MGQSNSRSSPAPPSDPRPTPRSQSSTPIPTSLSSIRSHSDQPPNSSPSSPRSHRPSTFNRTIRHLLSHPRSSQDSSHPSSPSIRKRWRSSRRFSKQSSSLPDLPDSSPDDHLTPSTPIAQSESHSDPIDIATPSCHPQLPTSPLRQSSPPYPPTQRTPSPTLPQTPIDFDPPNLEQSPPQPQPLDFDPPQLDAPQNPTSCTSQVPRVSHLPCPTDDEANGFPSDPKTNPVFTQGSSQDNQSSPLRVSSESRPHSSSFEPHPEPPPDPQPQLPRHFQSPGPLVVVQGVVNTSDNPAVPQNSGHTHPFISPISRRRSISSPRNDSQLEERQTTRRRISAFIPRPSSMLGRRPPTPDPASLPLHDTAFHDPSTLFHAQTSEPYVSQDDASASSEQDPRSSSEGDSRRRPLSPGSIDVLGTLLSVAAAATAASLFSPSLGFQAHADTNSPSLPSIPRPMSPTPTAGLGGGQGFGNLPGFGLDPSVSVSPPLTTTAQHREGRERLRSVWENIRERLGLGAPSSRTSDDAPLGSDGQNPMRPGEIMLAEMARALNIGLGLNNDDSNAESSEMIASSRIDEGSRSMEDIPSQRPPPPEDSFERFLLNLQVDLRAALSDDGGDSTLLTSAGEDGIDGRARRDSGDGAASRRILLDALPTGVAEADNDSDEPPPLEEVSDSDDDDEDAVYRAQASARTATPMPSAYSVPPSGAEHLSLEGTSGDESSNGDRGPPGINLWRLYRFQPIPATQVAGHASTTTSPTTPLSPTLASTTTSSSVPTAPQRPSSPEFPSSPLSPALPVAGLDIAPAVPATPGDASSSMVVPVIVVGLQSVDMGQVQGHGHVHQDPQMVPPSLQSDGRSTSFDSSGSTVLADGPSAATTRGRSWQTRAATALRNLRPGRRNSSSGRQAPDNTGSRTFLIYVIGGYYPPNHHMVTGSDNLDSYEALWELAELLGQVKPPVATREEIDRSGLQIINSDELARYEQQGKVASNCAERCLICLDDYSADEDLRLMSCKHAFHKDCVDKWLQVGRNNCPACRSKGVSTAGDVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLN0</accession>
    <name>A0A2G8RLN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_15113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLN0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLN0"/>
    <dbReference type="OrthoDB" id="2755203at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="195"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="342" mass="37527" checksum="E7AE59F33229DC2B" modified="2018-01-31" version="1">MGADYESNVLQSAVSATPTEAPVAPIDNTFGAILIGNFVGLLMYGIILYQAYDYFRLYSKDTRRLKCLVFALLYFYLVTNYFNPAALLIGTWSAVLMGVVMSIIIFVAQVFYVRRIYLLSRSYRGLVVVMSLLLVGELGACNPFRQISHDLSRAHTIFAPEGAATFAAIEGSTRYQFMSQAALTRIESTALVAVLVVDLFLASTLVVIFHRNRTGYKRTDSLLNILVIYTVNTCVLTSAINALALSFLIAFPTNMIYFGILTPATRSYTMAVLGVLNSRKALLEEYNRTGKSGAGGHKTDEESGNASQTRVKELSTEKGIKHSVTFVGEDTLIGQESTKGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLP8</accession>
    <name>A0A2G8RLP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RLP8"/>
    <dbReference type="OrthoDB" id="3232438at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1287" mass="143565" checksum="860442CBC7DD2EDD" modified="2018-01-31" version="1">MFICKGCNGSFTNSGWSNHLSQTRDPRCIAVRDEEEAMERALLLGLAPAASGSTVCGHDGAQSRGTLDPEDVDMDLPDLPDCDLDSPPILFAGDYFGAYTSDDDLYHVDGSVSRPGSPSEDSEFDVEEEDGWEPPAEVSGAASLLVGDAIPTAQHDRPPTPPPISDDPAHSPDSPDVRADIEAETTTKTYVVPYGKSALAGAPIPGATAEQAGHVRYGQELQSEDPRRPIYWPFTSKLDWEVARWGKKRGPGSTALTELLEIDGVAEKLGLSFTNSRGLNKIIDKRMSSGRPPFERHEIVVAGEAFEVYYRDVLSCIRALFGDPEFTADLLLAPERHFTDEEQEVRVYFEMNTGQWWWRVQEALDRQREGATVIPVIIASDKTQLTLIGNKTAYPVYLTIGNLPKRIRSKPSRHGQILLAYLPTSKLEHITNKAARRRTLANLFHACLRRVLAPLKSAGVDGIQLPRGDGLLATGCKNGECPKCPVPRAELGAATDTSRPLRDLAQVLDALSALDEGPRAYTQACREAGIKPIYHPFWEELPFANIFLAITPDLLHQLYQGVIKHLIAWLKEAYGTTEIDARCRRLPENHSLRHFSKGISKLSRVTGKEHQDICHILLGLIVGLPPHNGVSPVCIERATRALLDFLYYAAYPTHTSGTLKLLDNALKRFHANKSVFVDLGIREHFKLPKLHFLDHYRRSIEMFGTTDNYDTQHSERLHIDFAKEAFRATNGKDELSQMTLWMERKEKIERHETYINWCIRREARSSDTVQQCSLLPVNVTTQRPPGRPRQDRAQDDHKPPLEMTRHPSVRGVPVHELPDKYGATFFRDALKRFVVEHNSSGSLSRAQVESAAAGIYFPFAKVPVWHRIKFWISDPYDLTRHILPSSDAAHAHPERKGKYDTTVPGRFDTVLVNDGTGGVTGVQVSKRIPYTLADGFEQYLRVYVMRPDNTLNTFCIFLHTSHSVIDAKPGLNAISLLLEWMSISNLESVANLPWGTEYQNLPPGPITVTGGPREDWDINGTALLQKFGAFFGDPTPSHGLVGETTSIKDIRKVQRFQVTFTAQESKEIVQALKSLGFTFSELLDAATALATFELNPVSEDKFETARVANDVSVVSLTDRLPSTIDRRRHIVSCLVNTPLTIHYAPLAKLSGKTRLIAALRQAKEQYDAWLANPCLPHMSAELAQIAPPKEVTPSPSPFAPSMTNIGRVENYIATMWPKNVRPGEIPVFRVDQMHIGLRMAWVRPLVHSWSIQGKLSILVQGADNWREEVLRDLVNEIARQISFVMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLY5</accession>
    <name>A0A2G8RLY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_15215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLY5"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="354"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="718"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL22526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="811" mass="89058" checksum="32170D4BA91F152D" modified="2018-01-31" version="1">MTSSHEPPLADYLPPSKRPRVDNPQLQTPHNPIPGPAGPSTVAVPDQDGGADSASKKNRKRPLSCGECRRLKLKSCCKRGCAEICPDGALTGGKGSRFILANTEQLHEKIKSMSQRIRALEDALHELQSGHPLLREELLDIKKSADLFGVDPSQAQSSGGDRRNDAQHGLVNSLSPHMLSDRQSHSPPVNGHREDYNIPPDILGISHRFPAPNTLSVDLNPTLRKRILDLLPPQNEARYLCEQAAEHAAWHQNSDGSDGVPNLVHSVYNGNVETMNPHRLSYFLIILAIGTCVDQRRSPRAWSHDAERFHHLSRAALCETSVINEPSIDAINALFYMSRYLSMFSPVKEAVEYAWAVMGIATKLAIGIGLHRASTRSKVIPEELDKRKTLLWCMLNVDHRLSLMLRRPPSISLRYVDVDPPASSEYPAQGPREIYQRWHYTFTTHCISPILEMAASTTPAPYSEILMLDSRIRNFEVPAFMQVTPGTASGNALCVVQAWTHMTREVAILNLHRQYFTQALGEGFWANHKYATSVVAVYQAALSLLWCLETYYRQQPEYSVRSQMLWSNGLSSAIALSLLVTRVPPSVMASNALLELAKVLRLFTDVCDRCPLAAKSCSILETLFQRSRSTYLHSRYGTNPDFPLLDDEVCKIGVRSGAIPPPVRSSVPVGTETELATFPLEGTHSALIRAYEEATSTVPPPNDPILIPGPIHLGPSASINSPSANVSRNGAGPSPGMGGFGVSAERSGCQNDLSSGYGSIANMNVPVPTAGFSAAIAAGAPQTPQQQPQTQNQNFKWLSAEYSDNGWMTWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM30</accession>
    <name>A0A2G8RM30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM30"/>
    <dbReference type="OrthoDB" id="20524at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="264" mass="27874" checksum="AFA496789FBEE5B1" modified="2018-01-31" version="1">MLTSSYTLVEGRTSSPGTPSHSPPPSRDGPKKFQVSPANSDDSSIACDLSDLSFNYERNSRGEIVRVSKGSSKSSTPPTPSDSPPKAPSPVLGPTNYARPPALARSESLPQESFYPRQLQRTTSGSLSITPAGASRGFSTLAATNAGTSRKVGGPRRVRVEDLSDSDSQPRPNAQTAAGGTLEEKENQRARVIRPARSMGKAMAFERIAELGEDHDLPPPISSILVWHIRPSAPVDPPASARPRRPLIPSQNAPSSASGALGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMQ6</accession>
    <name>A0A2G8RMQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_15476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMQ6"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="37"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="494" mass="53743" checksum="A568F31EB2E3D9FB" modified="2018-01-31" version="1">MAPPYFIRNLVPRREKRTEGRPLLEALGSLTWVQWGHFWSGWLAWTCDAIDFFSVSLSVSRLQTQFHKSNPSDITTAITLTLLFRSVGAVIFGIISDRYGRKWPLVVNLILIAVLELGAGFVQTFKQFLALRSLFGITMGGIWGLAASTALENLPVELRGLASGVLQQGYAVGYLLAAVINLTLVPETSSTWRSLFWCAAGLSAFSAFVRVLLPESEVFIRAKEAQRARGETTTNKTRVFLHETGQMLKRHWLLCIYAVLLMTGFNFLSHGSQDLYPTYLKDAKLFSDHNATVATIIGNCGAIAGGAIAGWVSQYIGRRLTIIIFVLLTGAFIPLWILPTSFSALAAGAFCIQFGVQGAWGVIPIQLAEISPPAFRATFPGVAYQLGNMVSSASAQIEATGANNLHTTIRNSAGQLTVVSDYATVQGILIGVVAAFILVVTIVGPENYGSHFEKHKTAFEEGGGSDELEDDMREVGSRPTSVQVDEKRSTSEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMY6</accession>
    <name>A0A2G8RMY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMY6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMY6"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="272" mass="30195" checksum="77C83D678C15C740" modified="2018-01-31" version="1">MSQESGHVYTHGHHESVLRSHSWRTAQNSAAYLLPYLKPNMTILDVGCGPGTISTDLAKTYVPEGHVTGLDVPDIMDKARAHAASEGVTNVTFTPGDALHLPFPDASFEVVHAHQVLQHVADPVQMLREMRRVAKPGGIVATRENDMSGMVWYPEIEGMKEWLQGYMQVARANGGEPDAGRRLHVWAKEAGFPAESLTLSVGTWCFYTPEERAWWGGLWADRSVSSNFASTALKNGIYTQEGLQKIAETWRRWTSDENGWCTLIHGELIARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNF2</accession>
    <name>A0A2G8RNF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNF2"/>
    <dbReference type="OrthoDB" id="2783256at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="183"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="358" mass="41197" checksum="3D9AC0923ADB2410" modified="2018-01-31" version="1">MLLKRFCGLCPSPRIILYDMHPTTYYGYYGYGYGPGYWGWTPYATYPHGPQTTAPCRYPILVPLQDVAQHLPPHPFGAALGYHQQDTSTLEPQRHWAQTPWYPWAQIPWYYYQAQRPAPRDDDAPMAITRAPWRSRSPDRTLPERIPWHPWIDIDRDTRSHTQLTVDPILALPAPPFGTLGFQWDLADNPVRAILDRPENGWIRWRDLTRAAVRDGARALERLVLVFKPALRLPRERDAQIGVTHTHPATRLGADEDVAWVTVYDVFMAIFQWLVSPIGEAEMRRLGDGRFEEVIRTAEARRRGRAGRAGTVGREPYLKVDYLGERRRFKGIRLGVRDEVPVGRRLGEVFVIELGASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPA5</accession>
    <name>A0A2G8RPA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPA5"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="206" mass="23018" checksum="38681DCC59C88021" modified="2018-01-31" version="1">MSHDADSVSEQLGEFDLGNLYRSIDKHNVHGLNLTVPEDAQALIKPWDERDDTSKFAESGVDDQIIIHVPFTQNVRLRSVLLKLGRGELTPRRMRIYANRPNIVDFSEAEDVTPHIDIALLEGETGVTEYPLRTASFANIHSLSLFFSDAVGGDSIRLYFLGFRGDSRSQRKEGTQKLEIPAQVAPDAKLIDRLQEKSGGQQTTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPE4</accession>
    <name>A0A2G8RPE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPE4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPE4"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="404" mass="45327" checksum="1EE8AABC00534F0B" modified="2018-01-31" version="1">MSSPASSATSEVKQIRLRHPSRLHTRDLTSNTFRIYVKHYMDNAPPPAPRRRRSEARSVSPSPTPRGSRNQNDIDSPTNARGTKRAAAADATPRPSRRRRLEEGHTPRASQVSRAESDADSSDEEDNIEEDDRMYGFTLSHLRRVPELSLLARRVLAADARRREKEERKKAKEQASLSKGKGKAPASSSSSSRPAEMQVPTGPAVKKLYKQAIRTLFQEGDIVLWSGLVRPLPVPSLDPMLPASSASQLWRANTSTSSTISSASTSSRSQPNYEEWDDEVLSDPQPNEEAYVPLTPAYFSRVLEDAIRSMAHEKLDRAKGPQGERTPKPKPASKSIVERLREQEKERGAGPPPGPTKEELLTWLRNSDERWARVGEWTVQEALEWGRRDGRLWCIGKGRWEVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQK7</accession>
    <name>A0A2G8RQK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-D-xyloside xylohydrolase</fullName>
            <ecNumber evidence="5">3.2.1.177</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_13537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose.</text>
            <dbReference type="EC" id="3.2.1.177"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQK7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQK7"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06593">
        <property type="entry name" value="GH31_xylosidase_YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000053">
        <property type="entry name" value="Alpha-xylosidase YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007940">
        <property type="entry name" value="PRK10658.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117125">
        <property type="entry name" value="Putative glucosidase YicI, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="285"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="9">
        <location>
            <begin position="608"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00052064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL23787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="789" mass="87793" checksum="77902058CCF45A96" modified="2018-01-31" version="1">MRFNDGFWLLKSGVKPYHALQIVHGVQDGDGFNLQVSTKPIRHRGDTLAGPVLSIRVHSPTEGVIGVKIEHFRTTDPTPDIALFPDDPPVPSASLSRTENSFTVTSGGVTAEVTQNPYTITFKSPTRTLTAAGYKHQAIYDVPYKWTLRSASNNSCLTTDLSSNPHQGSAPEFVRYVHSELNISPGELVYGLGEQFGPFVKNGQSVSIWNQDGGTSSEQAYKCVPFYITNRNYGVFVNHPGEVEFEVGSEKVSRVGVSVAGSALEYFIIYGPSPLEVSTLEHSRLLPAWTFGLWLSTSFLTSYDEKTVSGFLQGMTDRKCPVRVFHLDCFWMKQYEWCSFTFDPDNFPDPKAYLSEIKQKYGVKICVWINPYISQLSPIFQEAVKGGYLIKRKDGTPWQWDLWQPGLGVVDVTNPAARRWYEEKLNALVDLGVDTFKTDFGERIPHANVVFHDGSDPLRVHNTYSVIYNEMVFGLLERRFGKAEAVVFARSATAGGQRFPVHWGGDCESTFEAMAETLRGGLSLTSSGFAFASHDIGGFEGHPPPEIYHRWVAYGLFSSHSRLHGSMSYRVPWQYGEDAATYMARFLDAKHRLMPYLYNLSIQGHKKGHPVQRAMLIDFLDDRTVHHLDRQYMLGPSLLVAPVFVPVGEESEYYLPAGRWTAFFDSSRMQVGPAWIKEVVPIDQLPVWVRQGTVLALGPTGIGRPDYDFANAIDVHVYELGEGQIVQTEVPSGKGADIAGVVETKLQGNEVIVKVASGEVGLASVTYFIGGQVHKVDVGNDQKEISLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRD6</accession>
    <name>A0A2G8RRD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRD6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRD6"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="153" mass="16456" checksum="A5C2AAF7936100AB" modified="2018-01-31" version="1">MEEGTKTRKTLFVGGIADDVDETVILENFATFGDVIEVQLPPAPTNPSNPNETKHRGFAFVTYASPADAQDAIDNMDLNELNGRVLRVNLARPMKGPTQAAGNRAIWESEEWLRKYAKPLSQSGGAALRGHGNEGSEEPADGEGGGDEDAMQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRH6</accession>
    <name>A0A2G8RRH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13843</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRH6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRH6"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013822625" description="Glycosyltransferase family 15 protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="44179" checksum="BC6267D6D05D61DA" modified="2018-01-31" version="1">MMTPMRYVVLVLVIIISLHFILSFSHEEYGRATSLSHITEQFSGSKPHPPYQEGVPDDRYVEQKPPIQTRKANATFVILARNGDLNGVITSMKQVEDRFNKGFQYPYVFLNEEPFSEEFKERISAMTDSKVEFGLISKDQWLQPSWIDEDKAAASRKDMIDHNVIYGGSVPYRNMCRYNSGFFYRHPLLHKYKYYWRVEPDVTFFCDLHYDAYQKKVYGFTISLYEYPATIPTLWNAVKEFIASNPGLVEHDNAMRFISDDGGETYNNCHFWSNFEIGDLDFWRGEAYSKFFDFLDEKGGFYYERWGDAPVHSIGAALFAKKEQIHFFNDIGYRHNPFQHCPQGDLHKKGKCWCNPKENFDYEWYSCLKRYDALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSM5</accession>
    <name>A0A2G8RSM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_14268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSM5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSM5"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11854">
        <property type="entry name" value="SH3_Fus1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035521">
        <property type="entry name" value="Fus1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="226"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL24512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="309" mass="34052" checksum="6108B86286B5D156" modified="2018-01-31" version="1">MAIIASPLARAAKRNLHPNEVVRNILPRQSATTDDGQPIVNPLPVSVRVLTALFVVLGVLVLGIITWRIVVWRRRKALTASQQYRQSNFSPTEKIRPIEEGRPLEKQEVLVILPMEPPQSVPATSVRWKPQIPRGHETSPVLDVKITPAEAARSPPPTYTPSGSPSTSPRPPVLKLPIVTVSDENSTLSVPGLPSPVPSPRRTSSFMKEAPTQASVKPKPSLKGQKLPRKMLVEHTFIPSLADELSIKVGDVLTMLEEYEDEWCLVERIGARSGERGVVPRFCLKERPRAHKRNKSSTSVKSSTSTKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTE8</accession>
    <name>A0A2G8RTE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTE8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTE8"/>
    <dbReference type="OrthoDB" id="2756893at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="475" mass="51086" checksum="0346997B6FC23EA9" modified="2018-01-31" version="1">MSAAHPLSSYPADGDSGNGSDASSIGFGMSYGAADPAVAYDDPALWCHPSATLETVPVVVPSQHQLSTLAILQAHHIPSQHDHSYDYVAQEAYQNGRLYHDPQPGSVHFTASCGTATTYSTQQDIPLHDPTHIHTNATVSRHSETFSTHCGQDVSSLGVVSTSKVASQPYSLPQLHRTDVAVTVPRFRGLPARSVTMSCPSFSPPAAPTAAYHDLTVPPPHFADQIPPTTAPFLERGRSFPDPRCVSGPLNVPQMESFAKPPRYLGPRHAHSPYASSPSLSSSSSAMSSLEASPVLPSNTYLEAASSHSASSRSSSAASSPFSTARHLHAAPTPSPPSFSGRLPLPLPLASHTQRFACLLCRGERTFSRTKDLERHIQSIHNRDPDAPRWICCGVPLSEADHWGLPDWVRSEPPYMLNGVPMVGGCKEQCSRKDVLKRHLRKNESRCFGSENAPWLPGNQVCKRSARGGHGGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU28</accession>
    <name>A0A2G8RU28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_12910</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU28"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU28"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="9">
        <location>
            <begin position="291"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL25022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="501" mass="55574" checksum="2909C388DF3C6DE1" modified="2018-01-31" version="1">MSANPELFPAIGSVADQTEKLPVEAQTMEITLDEEKPVQEIESLCMRCEQQGVTRLLLTSIPYFREVIVMSFRCDHCGFSNNEVQSAGSIRPEGAVYTVRVLSRDDLDRQIVKSNTCTVFIPEFELTIPPGRGQLTTIEGLIRDIVTDLGADQPLRRVQSPEAYEKIEGILQRCREVVPNDDDEDGDADATATAPRPVKIPRRAAEIDTPPKAFTIRLDDPSGNSFAEFVGSMSDPKWNMRTYHRTREHNVQLGLVAADEPPKEVETEAEAEEEIGGGAEGKNEEIYKFPGTCSSCGHPSDTLIKKVNIPYFKDILIMSTNCDRCGYRDNEVKSGAAISAQGKRITLKVEDREDLSRDILKSESCGLSIPEIELVLQAGTLGGRFTTLEGILDQVYEELSEKVFASGDAVDDHHAFETFLAKLKAVKDAEHPFTLILDDPLANSYLQNLYAPDPDPNMTIESYDRTWDQNEGLGLNDMKVENYEEDAAISETDKAELGVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU84</accession>
    <name>A0A2G8RU84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU84"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU84"/>
    <dbReference type="OrthoDB" id="2729552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33952" checksum="F9FC659BA65853E1" modified="2018-01-31" version="1">MRKLAKLIPLYNIDGTENHDGTIMEVAVLDMAIGDHREKVVFVVTDIGDEDVIIGLDWLHEHNPEVDWECGSLRLSRCPEACPAHQKASKPVETTACNTEVRLTAHNGPHRVRKAKMVGRIRAAVMVKEEEEDKPPPPGFLLEWDGTEESLLDALATGRTLCNAPKLFVSATYTYSQHLAEQEYQKKEICPVEEIVPKQYHEYLRVFSKEASECLPDHGPYDHAIELVPDARTFHSKVYPLSPSEQVELDKFINENLAKGYIQESKSPMSSPFFFVKKKDGSLRPVQDYRRLNDITIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUA5</accession>
    <name>A0A2G8RUA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_12986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUA5"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="70"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="432" mass="46366" checksum="423C94190BF0DB46" modified="2018-01-31" version="1">MSLFRASVPARVCLQRAPWSPSSLSPPTFCPLPILPSVPAISSRFMSSFHQEPHKLLVIPGPIEVTDEVLYANAHPSMSHVSPDFIPVFGDAIRMTRDVLFTKDAQPFLIAGSGTLGWDQVSANLVEPGENALVLNTGYFGDSFADCLRTYGATVDELLAPFGGTVPLAEIEAALKAKKYKIVTFTHVDTSTGVLSDAKAIAATVRSASPDTLVVADAVCSVASEEIRFDAWGLDVVLTASQKGLGAPPGLSILVASERAIKTFESRKSPATSYYASWKKWLPIMEAYESGNAAYFATPPVNLIYAYHASLKQITKSSVSLEERLRLHKESSQRFKKGAEGLGLKQLPLDGSVAANGMTALWFPEGLGASDLLPRLAQRNVIVAGGLHKDYKLKYFRIGHMGVSAIDGERGDLDTVLAALTDSLAEAKTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUC5</accession>
    <name>A0A2G8RUC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUC5"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="162" mass="18737" checksum="0E9562D7FC7B644C" modified="2018-01-31" version="1">MVEYKSPLIGYENAEPLPTTVNKDGKSLYNPPGPRSAAYEEFPNPIISSNNGFDFHIYYLPNSPDDAKYAAELHERIRREFPELRIYRFWDKPVGPHPVPMFEVNVFNPHQTGMLFSWLVVNRGPCSVLIHPNTSDPLRDHTELATWMGKPYPLNLRPLMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV66</accession>
    <name>A0A2G8RV66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV66"/>
    <dbReference type="OrthoDB" id="2742161at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="444" mass="50712" checksum="FE35E074A1E7EB09" modified="2018-01-31" version="1">MSSGHQHDIINDFHSDMNVRRVHAMPTTLSERYARAIEHKERTADYLAALEDSIDDDAKLARWQRRVDEWIEKILHREEEVSLDETPYEIGQEFKKTLTDRELLAKITQERSLTTKSAIGLLSVIQDGLSLQQERQRLLDRLDTESESPKGGDLGERCQTFLTDAARWHVLVDAYLTPLIEDAVRQLTLQAAATGQSLGSRGPDFPLRDTSHDTGNAAQGLHRGRSARNPNDAWSEIADIVLPLPSSYVKDLVELPSMLEPIAIERNLRQVAADHALEDVRTALIGVGYLQVEKKSKQRKTHTTRAQGKIQTAQREADKAAGMEPSHPRYQLLNPHDIVPFSMASDRTTVGQSRQRTSWIWENFVFTTPEGGEGNFADFHEEARRVHWSRSSATYTRWCEEVELLKEEMQRTVRMFHYYRYHWDATTRREEEAGNAGAAAYARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVF5</accession>
    <name>A0A2G8RVF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVF5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVF5"/>
    <dbReference type="OrthoDB" id="409948at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE/SOLUTE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47567:SF1">
        <property type="entry name" value="NAD-DEPENDENT EPIMERASE_DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="119" mass="12403" checksum="CBE70E0D077C7E52" modified="2018-01-31" version="1">MPTAAGSSSIIASLVQGPRSRFGDTAANGLPALSKTVFVSLATAGLRMVLTPVDTVKTTMQTDGNAGMEILRSRIQRHGIGSLWYGALGTAAAAFAGHYPWFGTYNYLDEVPPAPTCVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVK9</accession>
    <name>A0A2G8RVK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000047">
        <property type="protein sequence ID" value="PIL25551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVK9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="30056" checksum="13F9908E8DBB777C" modified="2018-01-31" version="1">MSTNPSKRKREVSPASPASVKNEDLGELCLAGESPPPPSQPCGTVKMSASQKDVIVIDNDEPSPPGSDPTTSTAPAPCPEAETLIGLDQCFKGQHLWLVNTLLAQPVATHDTICHLSDVPSDAKWNGKNTLVNSLGRAIVIVAFGSLSSVNLVIARGKATTLSVSIDLLREKDVESLRRVYEVAQVPNSHDTGKLDAYRISYDPRSRIMNVFDLTEQMPANPKAKPECIGVNALIGGDVMRMDMRCVRVRQPDGVMAVQFKMKAAHLLVAVPRAVDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVQ8</accession>
    <name>A0A2G8RVQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVQ8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="492" mass="54389" checksum="ED85E61E08582822" modified="2018-01-31" version="1">MQLFVGLRAPASARLAFGQTCTRSLSLLPTVPGPAPLPSQSVCAMHGDVHLPGQRHRIPRFVVELHDPVQHVVRPLERAHDLPEAGLPAARDAAGHDDVDYDLYGDVHGVRRRRRKSSNRQRPQARRPHPPRRHPRDVPRRVRLLDNGPRGPVPHPPPAARERRRDRRARLPARLLPRPRGEAGDRAPRALRDDTERVGVRGYRADVGLHAGVRGDGRARSECDAGRRDRVVAGVGPVGPEPARARARLCAPPRDFEFRDRGRVVHVWGDAGVLPGARPALRLDDGHRRRFAVHEQRVRVRRHLLLAPLERRVDGHGWIQGVEAQTGHAGAGHDAGRGGVGPARRVGRGVLRALGLHPRLPDRVDRVSDDPRSDQLVDRHRLLHQGCLIAFVGIYPTLIIALVALNKSRADAPQSSGYALPTLGGSFPLSPLRRNSDLSTVGDVRQRASHRAGLDPFAKRMPSDSETFTHLSEETVHWQDDGDETGKESFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWA1</accession>
    <name>A0A2G8RWA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWA1"/>
    <dbReference type="OrthoDB" id="2752751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="69468" checksum="EFC13E948013B797" modified="2018-01-31" version="1">MAMVHSATSPSLPNAPDILCHIFSYLDPVHQFGDNDVYESRRSLALAARTCPSRGFASPALDVLWKRLPDDQPLADLLCEVGIAIREDNAQTFKLSGEEKPSHHWLPYQDEGGYPLLGKAEYYEECWRLSRGYDVKYFLWTTGDPRTQPGWHRFVEHVSRVRAITTLFAFDGPAWCTIWEELLAVTDHAPVLPKLQSVAFCYFSSTALNTAAFSLLSPSVRKLNLNIDNEDWSESDVKICGIFTHSFGAAPEIEKLQLECHPSGLGLSLLQTYCSHLHRLEVSLPLDLEAMQLLVQLPALQYLSISLTQWDFSETSLSFAFKGNWETPGLPVIFAELCSLAISCSELRLGVVDPLLTHVEFPRLQSFSLSEKHIEFNNVSEKFPSHLRTGILLAKCPSLTAFAWTSTHIWDPHTGYRGGHRASIAPLAQLVSPLLSHRTLRRFSVQLNGPLVPYTPADFCAFAAAWPDLETFHLVDEEGSSWGLGERFADLESVFAFACYCPRLRSLALPRLEEHNSEALVNAAARRPPAPHWLRELSTTIFLWDEVWDWDRREKIVGQSHGLMQDVFPLVTLQRRGPACRTGEIENGRQQAVQSLSLSTIMHLGLSRDIPAHSGSTPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWS2</accession>
    <name>A0A2G8RWS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1365 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWS2"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013560412" description="DUF1365 domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="61727" checksum="17CD6C3211925A1E" modified="2018-01-31" version="1">MFAAAAASVVALAASAVLYLKRSSEDPGDALKNAYILENSVTHARLLPAPSTHAFTYPTLAFFLSLDALESHALDLGGGWLFGYGGTSWRVTGLRSNAYLLPETRGDKRETRGIKAKLREVLVEHGHDGSQLGDAWMLTMPSYMGYEGINPLSVHYCYTKDQGRLAWVVFEIHNTFGEKHIHVLVPGVNEDKNCPNGFDHSWTVPRDFHVSPFNDRQGHYAISISAPPPPRSPALVSSPPRPKIRIHLHAAAESSNTASASTDVIGPLKLTATQFARSSVPFTSRNLGHALMKYPLALFLSFVRILYHAYLLHYVKGLDVFPRPDPKPAAPHWGSLTSRSIPGQGEHRKAQIVPRVYGGIGWQDEGPVEAYARRITEDFFARRAEELRMDITLVSGDPSVPDLTFSPWAPPTADDQDAAREELIIHYTAPRFFTTLLLAPTAEHLLLLRRTDDLFRVSSDELFVRMFSVVPPADIAVSWTQQLRTSLLPRRFVSAVPITPRHPLDSNSPRLLTSFAVCLLHFADAVEKNVFTLLRARFVPGTEPWRRWERAAAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYS4</accession>
    <name>A0A2G8RYS4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000043">
        <property type="protein sequence ID" value="PIL26634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYS4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYS4"/>
    <dbReference type="OrthoDB" id="2773795at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29257" checksum="048C3AA6E5514770" modified="2018-01-31" version="1">MDEVSTRNGGIGCSGPPSPRISTEVCENIIDMLYSNLARDTFHDIGALHSCALVCRAWRVRSQRMLFYKIQLSDGPSIHRLRAILDAGPHLRGYVHEVTIIGYYLDTTASVFAIFPAVFAGKLPNLRRVDVVHLNEGTATASWYPRTSHPPYWAKPLPHIPLHPRFPTFLSSFTAVSYLTLTYTVFRSFSECARMIGAPPSLETLQCEYVRWLAPGGSHPGADITLPPDWAAAGPNVPLPPFAPKLRELSLWDTALYEAERLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ02</accession>
    <name>A0A2G8RZ02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000038">
        <property type="protein sequence ID" value="PIL26742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ02"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ02"/>
    <dbReference type="OrthoDB" id="2755377at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="375" mass="40371" checksum="32006A13B7C9B060" modified="2018-01-31" version="1">MYSPGFAPITGGTVLSSQTSGRLGNNNTRNAFPALQKLHTSDNIPSNDVEFSGTVLPLISSTSLTVLDLTVSLRSPSKIPEYFDEICSSAAIAPLRQLHLRIYVTSRPQCAMGMGIFARDTVTHRIPFADILPHLARLPALTDISISTESRILSNDSPSVLVALLDVCDEDLAAVAAAWPDLARLSIAYSDWAGRCRGPCMPSLGAVVALAGRCRKLERVDVEFADVDADELVRLEARASTSTSTSLGTCCTPAPGESGSGSESSQSLREVQTALRQIATVSGLRPQPPSQHRTGNIYLKYEHHERLSVAEPLRLAAALRKLFPNLRSGLEESHVVAGGMEEGLRRGDNDMVIDPETDAMRLLKALDELDLDAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S068</accession>
    <name>A0A2G8S068_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S068"/>
    <dbReference type="STRING" id="1077348.A0A2G8S068"/>
    <dbReference type="OrthoDB" id="3051303at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="152"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="333" mass="37879" checksum="1014C8342C7D9CC5" modified="2018-01-31" version="1">MGKVDALSRRVDYETGPVVKDVTLLKAHWFAASHTVDGADNLKDMCLKHVKLYDRSVVEKLGKDNDWELAEDGLIYRRGKMVIPNHPELRGRVIASHHDSIAAGHPGAAKTQDLIMRSYWWPTIRKDVIKYVTGCITCQCVKIDRQPRAAPLNPNPIPDQNWQFVTMDYMTGLPECNGHDAILVFVDMKSKDYIAIPCSKTLDSEGQARLFIKHVVVPHSLPKRIWSDRGPTLVSSFTKEVYRQMGIEGNPSTAYHPQTDGQTERMNQEIQTYLRIFINYKQDDWVEWLPLAEFAYRCRVHASTGMSPFFMTHGHEPNTGVETLKDGINESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S079</accession>
    <name>A0A2G8S079_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S079"/>
    <dbReference type="OrthoDB" id="2756724at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013909937" description="Transporter" evidence="2">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="22697" checksum="7C772C5876D118FB" modified="2018-01-31" version="1">MFFSKLSVIAAVAFGALASALPLDLPVVGSLPAVGSLPVGSLTGVVGSLPVGNVLSGIGRRDTPKSVAVILTGVQAQLEPITASLTFITTANATVEAVTGPANEIISILGGAVVDLKALVGLDASVILASVDGTVAVTVDVLAGLLAHVIVSVFFSLGAVVHIAGSAIDGALFTLLATVGAAVGTVVALVFQLVVGLLVGLDVAVVGLIKAVVPVIVDLNVHVLISLFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0D7</accession>
    <name>A0A2G8S0D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_10348</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S0D7"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002928">
        <property type="entry name" value="Myosin_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01576">
        <property type="entry name" value="Myosin_tail_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 11" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 12" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="16">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="15">
        <location>
            <begin position="77"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="11">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1069"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1259"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1638"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1976"/>
            <end position="1996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2323"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2421"/>
            <end position="2441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1280"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1456"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1740"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1808"/>
            <end position="1849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1269"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1676"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="2430"/>
            <end position="2441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL27204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="2441" mass="278924" checksum="46B859945C207204" modified="2018-01-31" version="1">MPAPRPSQSAEAARAAAAQAEFNEKKWVWVPDDKDGYLAGWVVKEEDDLGEVVMASGGEIRKVPLYALSKMNPPKFDRVDDIADLTFLNEASVVHNLRLRYGSGAIYTYSGLFLVAVNPYQALPLYSDAIVHQYRGKRRDENPPHIFAVAERAWVNMGEERENQSILITGESGAGKTESTKKVIQYLAAIATDAHAPSLTPSHSQSPSLSSPAFTSVVPAIGLPRSSSLRKHTKGTSVSGPGSGFGLTSKGRLGLLERQILQANPILEAFGNAQTQRNNNSSRFGKFIRISFSPDGSIAGANIDWYLLEKSRVVVRSEAERSFHVFYQLMEGGGSLKETLLLDGDVEDYEYLNKSRREVDGIDDREEWNLLKAALDTVGFTPAEQLDLFRVVAAVLHIGNIAIAATRSDDATMPDPSQAERACHLLGLPLSEFTKAVLRPRVLAGREWVTQARTRQQALDELASLCKTLYEKSFGMLVDRINRALDRPSSKSTFIGVLDIAGFEIFDVNGYEQLLINYTNEKLQQFFNHHMFVLEQEEYAREGIEWDYVNFGLDLQPTIDLIECSGSTIGILSLLDEECIMPKATDRTFTNKLHAIWAAEPQSGEEPHPGTFKYEQARFEQGFLVHHYAGRVEYRTDGWLEKNKDPLNDNLTRVLAGSSEHYIASLFAEYSDMPLPTSNALHAATIGKKRVAKKGAFRTVGQRHKEQLSVLMTQLQGTQPHFVRCIVPNTHKKPGRVDVPLVLDQLRCNGVLEGIRIARLGYPNRLPFVEFRQRYEVLTPGIIPPGYMDGRKACLRMVDALELDKSIFRIGTSKIFFKAGVLAELEERRDALLFDMFSRLQAVARMFTARRQMKKILNRAVAIRTIQRNARIYGELRDWPWWNLYTKVRPLLAATRNDEELRRKEAELILAKERAERDQREREALEGLKMRLESEKRKVEEDLEAERAVGVDKDMLLERTKKHEVELEDEILALQSDLDTLDSQLDRALKLQKESEEKHKTLQEAFSQAAEHLVRLESEQNDWVERESKLNKDLDDAQVELDILAAEKEMLEKQGEELKNLLAQREEDLSRAKERMESTMSDLDTKLSTEQRNKDALREKAESLEKDTRQLKEQLAEMARTATDYSNMIKSKEQQADKLSDELDKFKGDRDALLREIAELQATIDTLSAELDSERKDKQRNASAQIKLQAELDELRALLEAKVTEETRRSEVAKSKEEELADLRSQVSKLSADLTESRRVAVETQNKLKVDLETITREHKNIQSSHQSLSDREQASRTQLKKTEVVLAEAEKSKRSIESELQSIRSRAIDTDNQLAEVQRAKESLERQLASTQSRYADFEDAALQLERDKAALDRQVETLKKQLDAETAKRTKLEETASKHKAEANRLKDINLKFEKDMNQVLKDLKTREWEVKQLEAKQNKTIIEHVHVLEEAKRVTDRQLAEAQVELQKQATYIRSLEKTRTRLTTEAEDLAREKANEELAIRVKEKKARDQEAKATRALADFENERRAREAAEVHVKRLQNELKDAQAQVADAEQRMIGIQKAKDNLEIELTRLADETEVPHSLSKVQRQYESRISQLEAQLEESELAKSAAARIKEHVDRQHAEIRRLIMSSGPKDDSFRTRLLRELQLADEEMERELSHRAQAKHLTGNRTGEQNLGPVTPTKHRSNGTVRFKDGPPTEIPRTPDRHAQVNKLRQQVQALELQMAASTRIRQYLETSLREVTEELQHSDGSKQSIESTRTRLAKENARLAELLEEEAEARRAAQAAQIDGVQAMWDRFQNTIDQERESYTRLDESRKALVVQQRAAQMEVEDQRRQVQELTASKKQLQGEVNALKERLDAEILAKNDELAVKRSVQARLQELEITSSATATIHSELQEAIDAYKTKTDEYLKRYEEAEINRAKAARAEAFARRALADAEKAQAEAVADRQGTEQRLLGAEQRIQELERKLEEEGRETSDLALLRQRLAEEMEDERKQHQQEAAERDFAADQTRKKYQAELAQLSEELQSQRDTMSRLREESRKLRSEYDELQLRYDDEVYNGGSWKKDRERLETKIQDVTKAYDASVAAQAEQQSQIVSLHSQVRELRSVLNDAETDRALLQKARRALQAELETIKMDHVDTNRMSSDTELQRVRLEKQDLERSLEEQGDRVSMAFERMKKAETYANECQIELGKIRVENSELDRMNANLEKQVKDLNVRIVDLETRSLNAPRPAPTSRRLESRIEELTSQLSQSTKDSSRIHRSADKALQEVDRQRLRLEDEVKNYESKIVSMRQTMDELQTSENNLQLAKRRAEREAADFKQKSLNLEREVERLRSRLERPSSTLLGSPPPRKSGLASADNGTDRDKTNVKMPKEIRDIKQFIDIARRKDAKAARIKKIASRVPGGKTKTKFKIRCSRYLYTLSLDDPEKAAKLQQSLPPGLHVDEIKDTPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0J5</accession>
    <name>A0A2G8S0J5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0J5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0J5"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="90"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="553" mass="60426" checksum="EAD1C7D0BCD2EEFC" modified="2018-01-31" version="1">MSGLSSLQSSTTTLHVISHFHTPLQDTFQREETRTEEYGGDDPQGPSPKDGDTLPPAKEVSSPDPNLVRWDGPDDPENPHNWSLRKKWAITALCVLLTINVTFASSAPSSASTYIAKEFGVKTEVGYLVTSIFLCGYVVGPLLWGPGSELFGRQIIFRIGLALYVVFHLGQTLARDMATFLVTRFITGVFASVPLTVSGGVMVDIWDPANRGIAMAIFSAGVFVGPVLGPIAGGFIIMSPIGWRWIFWIMMMFAGVCTVLAFLFLPETYAPVILQWKAQRLRKADPEANSLLYSEHARSDWSLSGVLHRTLFRPVQMIICEPILLLVTIYTSLVYGVLYATFEAIPFIFITTRGFNIRQVGLIFIGVGIGTTIGAYIAIRLSNRYNVLIPKYRGFPPPEERLYGAMIGAPSLVAGAFWLGWTGQYSHIHWIVPALATVPIGASVSLVFNSFLAYLVDTYLQYAASAFSANTIVRSCVGAAFPLFTLQMFVALGIGWSCTLVGLCGLLLAPSPFLFYRYGKRIRAKSKFSPCPDLAIAKLIAAEEAAAAAKEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0R1</accession>
    <name>A0A2G8S0R1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0R1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0R1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="342" mass="37697" checksum="B7827199C88404DC" modified="2018-01-31" version="1">MPAITSGTVLVTGANGYIAVWVVKSFLDQGFSVRGTVRSESKATHLRSLFKPFGDKFEVVIVEDITKEGAFDEAVKGVDAIAHTASPFHFKADDPDELIGPAVHGTTGILASALKHAPTVQRIVVTSSCAAVLTPSPEPRVFSEADWNEASIIEVEEKGREATNFAKYRASKTLAERAAWEFWEKRKGEVQWDLVVANPPFVFGPFLHEVDKPENLNESARDWYDTIVKGTKDTEALVNIGSSYVDVRDLALGHVLAVTKQEAGGERIIISAGPWKWQDFVSVAHRLYPSLPAGNTSYDPATTVHLIRYAPDKERKLLGIKFKSLEETTKDTLDDFKARGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S167</accession>
    <name>A0A2G8S167_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S167"/>
    <dbReference type="STRING" id="1077348.A0A2G8S167"/>
    <dbReference type="OrthoDB" id="2749860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="262" mass="29110" checksum="7DCEA6A0340959C1" modified="2018-01-31" version="1">MSEFTLPTGVSIHNTLGAAFIGNIIAAALYGLTTLQTYTYYGRSGDDPRILKHLIGVLWIFDTLHVVLISHTVYMYAVTGFGQVLVLFDPTWSVLVAIILTGTSDGLVRAIFCYRIWILSGRNWFVCGAVTVSSLLVLACSIVHIMVPFTADADADGFVSWQEFHSFIELEDISYAAFPHTMIYIAFYFMLPKLLLNSLLGTLNARRSLRDNISHNFVTIPLSSVATANREMTGGSHINSELNDIYPKVEEDDDMNVVQHAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1Q3</accession>
    <name>A0A2G8S1Q3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1Q3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1Q3"/>
    <dbReference type="OrthoDB" id="2596255at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="157" mass="17055" checksum="22AC51B9A0EE7A1C" modified="2018-01-31" version="1">MDDHFAEHASWHTIRPGHPSLCLSVREITSVSVTFVLSSPYSAHDPDVSLSSLGLSSDDDEDEASTSRPSASFPDTQRPPTVTDIISNGFSVKVNGTPWRKVIVKDDVADEAIIIVHGLMPARQYDVELGIMPGESTVRGQITTVRLSLPVIARYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2D0</accession>
    <name>A0A2G8S2D0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_10861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2D0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2D0"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="282"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="663"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="911"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="940"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL27708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1035" mass="115160" checksum="68B0AB35881FD69E" modified="2018-01-31" version="1">MGLFALAVPAMIFTHLFHRQSRNRDYDPEKAVRRDSDVSNGSGHEDSDGEGRDHSSHDILTSDTHHRRFRRVYSTATRTVVSGLSSSDDLSQSAPSVFKRFKDYVWPSDEGLVDLDSFVPNYRWIPIVAGTIIPFSILLEIPGLTEKWYIKTENNQIVAVQPNPPILDIGVAFSMACVAIANLLLILRFLEIRIKTVTLLCFLFLTVHDIINIVIITVFGVEHRFDDGFTYGQAFWSTLCSTAISSCTNILLITDFIRTPEFAKRGSGLTRKQRALVILVMVLLLYIAFCGLLSSIILDLTYINGLYFTVVSIETIGFGDIVPVTTGARVWTCLFISFGVITIGVAIAMCRETIMEGLEIGYRRRVRDLRERRRDARRFRRWEARWRRAVEFRLREKGEQIWVADAPKGDEDAIRVLGLDTGIKLPFFKRVGTKIKRTATVDSVLHPRHRRQHLNVEALSNAELEEAALEAGVPLEMFCDLGARRDELHHTPMPELLAHVHAAAAPDPLGVVHAVQDTRTAALHHALSSGWVGHPETPTQAQLGRMAAMLTKFGLAVSGHHVHPPGQPHGAYVEEAAVEHPHRPPPHAPVSSARPWRTSLNGSLLDGDGGGDVCRHPTTRWLKEFAKDVGQRPAWNYEKLKEVSAQEERRAYYAKLTIAWSLFLVFWLAGAGIFCATEGWTYGIGVYFCFIAFTTTGYGDYTPETPAGRSIFVFWALFGVGTLTILVSVLQEAGSSRYKTALHSRVFDKAVKNYRKNNKQILDVRHPLSAFEKDHDHLCNPTKPIAVRLQEAQEKTQRALELLPCDVVRNAKTFRDYVSFFVSASPGGIEGLAEAGIDIGAAKVPPDMRKLLDELGDIEGISARLKSEILQDDDARKTLFMLGLERNLKKLVGAAEKALLALTERDALATLDHQEQREKEKRRGRSSLARRPTGFAFDQLDLKRHDDDADRTHTVRAHSEPPPSGSRRVERIPRTGSETSIRGPENEPTFFLTNSASPISGRSRGTGRRGQSASSSSSSDVDDSESSSSAGPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3B8</accession>
    <name>A0A2G8S3B8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3B8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3B8"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="122" mass="13534" checksum="9D50E671B130528B" modified="2018-01-31" version="1">MSDPQATSTATSQPHATSPELEQTLTLLTSHRSVLGYMLLSRGQPVTIIRHSGVVFEGEQGKKYASAIARIVHSVQTGLEDVSGGHTDRDELRFMRIRTKRHEIMISPDERYLLAVLHDPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3R9</accession>
    <name>A0A2G8S3R9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2OGFeDO JBP1/TET oxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3R9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3R9"/>
    <dbReference type="OrthoDB" id="2744819at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024779">
        <property type="entry name" value="2OGFeDO_JBP1/TET_oxygenase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12851">
        <property type="entry name" value="Tet_JBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2OGFeDO JBP1/TET oxygenase" evidence="7">
        <location>
            <begin position="236"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL28433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="456" mass="49733" checksum="023E78A9CACECDE2" modified="2018-01-31" version="1">MDAIAHALPHQFARRAATAQFMVDLESYYTGFLEGKSTREIVDMPIPPDHLDHAAVEDCRSISAMVALVRQTVYQVSWDAVDYANDVSKAALPNPDVEARLMAKYPPLIPCAEVICRQDDNLPLIVGPAIVTDVKGRILLWSLPQVLSDTRQAKILRDTRLLEGQMTIEEPEPGAKVTKGWRTVSTFYSKNGEWISGSTLLYPAGYQQGHVGSNFNPAPSADVRTTRAADWMAAFEENGGILDGILAMTHPKLYEAAQKATETIWREHSDSRAIMATWPSCFSALQVIINRSTLGHCDCHGAPGWFDLLVTLGTYGKKAVLELHGLGISLPYNAGTIVPLSSKLLLHGVPKVRGERVCYAFYMHSAILGHFNVPVDAVTYSEARRPRDHVLGHLTEHAVAERLRTLGLSTDLPRGDLGTSAHVKHKADGDGKDGDGGSEDTGSMGGGDDEDVEMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3X7</accession>
    <name>A0A2G8S3X7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3X7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="99"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="458" mass="53551" checksum="42CA6B97516D3FCB" modified="2018-01-31" version="1">MEPSIWATQKQWKEPFKESSQTPLTVNGKKSKEQSSRIFTSTRRIKPRNTEDSHWTYLKTTLRSLQPKVRAPHLQRYMNMLSRDWGYRFHNGVNHKEPLKSQEKEEDQAEQEHQELAKILTKTANLTLEPLKGLTDLKGLEDLADREDQVMEDREDQEDRVVEDQEDLAVEDQEDLVVEDQEGETLQAHLEDLRYLTPHNREAKLRSKPRKHLMEIDPSSKISLTNCFYSSWETLPSTPQAMLELQQRYPIWEDPTLTIGDRIRLINFVKTQIHHPGKTSKENSDSNALPPWLRQRVATSYPLPKNITDWIGRTVDIYEADLINRRIDANFRNRRPRKQTPQAKVRRNVQEHIEQPGVETSASADINKMTVEERSRHMEQNSVSSVINQDTSHEPVLIECEKVRPGRRVPRKIRQVTQEDLEPIPEETEEDEDSGTEADDELQIDIVQIDSNPYDMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4E0</accession>
    <name>A0A2G8S4E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4E0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4E0"/>
    <dbReference type="OrthoDB" id="2758131at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="71" mass="7828" checksum="2B28FDBE5A3EC9F6" modified="2018-01-31" version="1">MLFISSPYTISIASEINSIAERFVTWTPPTDTVDMTLVVFVFDDVESYDTTNAFVVQPVASLHQFGHLSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S549</accession>
    <name>A0A2G8S549_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_08903</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S549"/>
    <dbReference type="STRING" id="1077348.A0A2G8S549"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL28857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="316" mass="33835" checksum="ED2090CFA2E7C65E" modified="2018-01-31" version="1">MGSLAAFPNPLTLTGDSFFVHDPSLVQRASDGKYFLFTTHNKGGIITATNLAGPWTSVGSILPNNSTINLTGRDDIWAPDVSLHNGVYYAYYSVSTFGSQESAIGLATSSSMDPGTWTDHGQVFRSTTGNAYNAIDANLVIDENGTPVLSFGSFWSDLYQINLGSNFQSVSTSPVQVSFNSTSPQPEEGSFVWKHGSYYYFFFSSGLCCGFSASALPPAGNEYKVFVGRSTSAHGPFLDKSGKDLRSTGGTLVLASHDNIYAPGGQAIFTDSKSGKDIFVYHYIPVNSPVPYSDTYASLGLNAIDWSSGWPVLTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5A2</accession>
    <name>A0A2G8S5A2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09013</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5A2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5A2"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013809109" description="Transporter" evidence="3">
        <location>
            <begin position="21"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="89"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="426"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL28966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="61301" checksum="676BCC757CBD17B4" modified="2018-01-31" version="1">MPASMWKHNVGTLMAGGALAFSASSLSVVDSVQDKLGDLVLSSCTGNDTIAGAECGYAVVPLDYTNSSAGVAKIALGRYNATASPRKGVVFVNPGGPGGAGVLLATQVGQLVQKLIGEEWDIIGFDPRGIGLSEPQTKCFTGNASREAFIANTVLDRGYDISPNLTDPNNRFHLIETQRDANALYQAQFEVCNQTMGETIRYAGTTSVVRDIDYINTLLSGNDSLINFYGLSYGTVMGQYLVNMFPDRVGRIVIDGVVDADAWANKPPYQQLPSWLNSTDAVYKLLFEDCAKAGPSACALAMEENEDPTAIMVRVEDFVNGLYTQPLAVPNAALPGILTSGRARLFILGGLEFPEMWPTIAAGLAAAMAGDGSAMLDTVNTKDLVDLERSAVSCNDQRPFAAPSAETVVDAGLAALESVSRFFFSVIVSEPDSGCQYWPVTPPERYLGPWNKTLNNPILIISNTDDPVTPLANGELVHSYFPNSSALLVQNGAGHTSTALTSLCTIGYSRAYFANGTLPAAGTVCEVDESAFTAASNSTLSNSTATGAVGAVANSKTLASLGGSVRLSDFIHHGVKAKAGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5E4</accession>
    <name>A0A2G8S5E4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pterin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_09037</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5E4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5E4"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="17">
        <location>
            <begin position="536"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="254"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL28990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="867" mass="94907" checksum="3E87CE29F6F22636" modified="2018-01-31" version="1">MGPDVRQTNRSDYVRVNELALNVSFSDGSRWPSAVPTPQPVLVSFSFAHDVRNAAATDDLAHSVNYSTLASGMKAIVESEVFPSLEAFADRVCQVYALQYSEVSRFTARIARTKTLLYGAAFGVEVTKLSRSRAPVEETFFFQDLLGYAIIGIHAHERQRKQRVRVNASITRRPARQQRFNFRTLEQRIFDFIDDSRYLTVEALASNVASTIHSFLKDESAVVSVRISKPSAILDADSAEIEVTRTARDFRVEQSQIASSSSTTPISQTAAQNSPKDSLSTSKSAPPSPATPSLPHRAAIAIGANVGDRFANIECALRLLETSFSDAEQPKGAQRIVVVDTSFMYETAPMYMEDQPQFINCACMVETDLEPRDLLSHLKRVEEIVGRTVTFRNGPRVIDLDIVTYDDLILDTRPENARRNLDNLQGELVVPHPRVSEREFVLRPLADMIPDYVIPRTQKTVKTLLSELAPQHVGGEAMYKVIPFPRYPLPHTENASGSKSPFAAKVPVPRVPPTATYWKYPITPHTSSGKPPARKTYIMATLNATPDSFSDGSVHYALPDALSYVAAAVTSGANIIDIGGYSTRPGAEFVSPEEEFSRVVPVVQAIREDGQTLRRETAQTLISVDTFRWEVAEEAVHAGANCINDVYAFGGVEYPPTERSAAHFAKMRQVVRDLAVPVVLMHSRGPAAENKDYSAYDYAKDADGRGAVLEGVRVELGEKVERAVKGAGGVRRWMIMVDPGIGFSKTVEGNLELLRDAASIIAPAPLHPTANVENENSPPPSRSARNPLEGYPLLVGTSRKSFLGALLQEPDAKGPGSYKGRQTRPDERDFATAAAVSCAVQQGASVVRVHDVLGLGDVVRVASALWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5M2</accession>
    <name>A0A2G8S5M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5M2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5M2"/>
    <dbReference type="OrthoDB" id="2754773at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="58"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="578" mass="64326" checksum="B6B8380B07D37FAA" modified="2018-01-31" version="1">MHLDRLIVFQHLPLAHLYPVHPHPPIHPRKVLFPACVIKSKRPDMNPSSGVKHSVAHINRLPNELLIQVFLLYAEAATPTSQRHTPQAANMRWLPLMLVCRYWRDVALATPVLWRVIHAAPQTRWTTLVLARSAPATVDFTFGDRGSLFTETFKVLSGHVDRLQRLRFVGVHGDLRPAALKFVCGAVDFPNLESLEFLIFARSPDTLADFADMKLSSERYPSLRSLQLCATIAPQDISLCSKLRVLSLTRCLCAPSFDAFLDILSSCSLLQELTLVACLQYLPDEWGTSSTPLATPIHLPDLTALSLRENPPEHTSRFLSSLFLPLTVKVTVMSSHRDEDVVPSISCILPPRHAEAIPALAQVTDIKLLVMHEYALRFDNRAPPLPGVFLFMTAWKVTLSSAALDLTRVFGCAPLTRLVISSNGTHIPTADVWASIFRTFPRLQWLRPRTLKSSITMANPFRNLPVGLHHVSRSGAASPACPELGVIIINGLATDIEYFDAWVECLRCRSERGLVLPKLEVGLRGSEEDMDAMSRVLEGRLRGLVSEYTAEPVFLCYTVFNRSSGHPNAVGPREPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5P1</accession>
    <name>A0A2G8S5P1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S5P1"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCD" evidence="2">
        <location>
            <begin position="361"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="977"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1446" mass="159787" checksum="2D9B077A99DCCAD1" modified="2018-01-31" version="1">MADAAEPRRSQRERKQATHFVSVDSSILNKRKRSDATSEEENGKEDALSELSDLSPSEDEADNEDGAPKQPAKAPSKRKTKAAPGPKKPRAPKGTAAKKTTVKPPGPPKPRKTAGRKGKQAAGADGEFDAERVARDSKISGDNPLFNAIMNPAAALQSTAEDYLESLSSTPGQSLADLINCILRSCGCNDSVDEDRAVDYDGVVDALDDFTEILKKDDTPIYPLTSKLPIFKKFRKSLSEFLDRLIVSSAELGSLYTSDLMRTLQTWVIAMSSSQLRSFRHTATVIALEVETALCDVASAVEKEAEVVSRQREGERKRKAAGNKGKAGGARDAELEKKAAEVRERRSKLAEFLKEFVDGVFVHRYRDLDPNIRAECVRAIGLWFKKYPAHFLDGEYLRYVGWVLSDAQTQVRLEAVRALALAYDQTAYIGAAALQHFTERFKPRLVEMAVGDVELSVRVAVVQVLQTIDGHGLLEDEQRQKLCLLVFDEEPRVRRAVSGFVKGVWEETVDERLVGKKPSDTDKSRAGVKALGMLLINWGRALDKTTGDGDGDDESDLGEGTSKRVRAKEVASLVGHNPKGRTALVVEALWDEVEPVRDWETLLDVLLLDHSAVDEGRPTSRSKGKQAASDEAVDEVYRLEEVEEAVLVEMLVATLRKALVDAAAATAKKGDEDTTLSDVTRALIKALPRLFVKHQTDESRISDVLLIPQLMNLDMYLEMRMVTAYTSLWEDVTKQFLSHSSPIVLANAVTTIRRMMEATSLSKTNSTKILELEDELSTSLRDAIAGRDEIEVATFTEDEVISLGAICARLAALSGIRDMTSWMEEDEGGKQSSAWDIVSALAERGRLGYKEEETMVDRALQLLTLHIMWKARSLPAAAELSPDEIQFRDKLKEERESLLEKLVEFAVGTQSNTVEGVRRAAFQGLLTLHILFCATETTAPDGSRLPTAALPLSLDDEVQYRCAGFVQTEIERYSEEIAEEHPQEHKSSDEEDDDEDPEPEEQPKVKRGRGRPKAAKAPVPPPHAETRSHLEKEYVFIGVVTTFLRAIRAGVIHFRHAATVLAHHGRLGPTFDLCSKVIIEILREEGMYKGNGETVVAVVCQALQESFTLYLESVAHTGDHAIALGKALSACLMIRGAQLAVVRRLDPKYVVDIHITSLNWVGKRLAAYENAKNKKARNKCILFFRVLQPLLSSIDNQDSLKIKAHLDNLIAQSKLEISPTSKPWEPYRAYEKKLSAALMKEKGPGRRGRRRKDAKSTELVTTDEEGGEASEVEGAMVNGNANKSVRRNPARRAAQNGGLSEGELGVTEDEHEAAEATTTPKARPKPRPVRKRGSPAKRAREESPVRTQSPSSVRQSKSPTPLSSIRGSTPAEEPEEPEEPEELEESQDPETPKVSRKRGRSNDEEPEDEEMADATTNGVDHADGDEEVSPDGQATELQIRRKRVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6D0</accession>
    <name>A0A2G8S6D0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6D0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="73" mass="8380" checksum="5BC8299BED5E1C93" modified="2018-01-31" version="1">MFSYSMFATLHIFIQVNIETIHAEYFLMPVSTLAFVFEFEDTVTEKLKPAVQPLLVARHGRSPQDPNRKTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6T3</accession>
    <name>A0A2G8S6T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6T3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6T3"/>
    <dbReference type="OrthoDB" id="2756172at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="148" mass="16186" checksum="399C52153B97B111" modified="2018-01-31" version="1">MAIWLITGASSGFAHELAKIVLEKGGIAALASEIDPTWNIKVTLIKLGPFLTNAAKGEAQWAPTHPAYDKPELPAAAFKSIWAQFRVVSSGDARKGMETVYELTSLEQSSLYFSLWREAVAAVRAKTNAVLEDTNKYESWSEGLERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7A5</accession>
    <name>A0A2G8S7A5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_08278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7A5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7A5"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12215">
        <property type="entry name" value="ChiC_BD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.20">
        <property type="entry name" value="Carbohydrate-binding module superfamily 5/12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="Carbohydrate binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="467"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="389"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL29641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="506" mass="53065" checksum="72CFD7A6CA704CE3" modified="2018-01-31" version="1">MAGQSRTLRALTALAVGIATVGVTAYDNSRYDNNSYGATHTDTANFQKTLSYYCQDDAIDVIPISFVNNFFGTGGAPVLNLANICNAVDNATFPGTGLANCASLASDIQTCQAKGKILTLSLGGGGVNVGFSSDSQAETFADTIWNDFLGGSSSTRPFGSAVLDGVDLDVESSGGNSFAPFVTRLRSHFSGASKKYYITAAPQCPYPDGNLGSVLNAVEFDAIYVQFYNNPCGLQVFNSPSGFNFGIWDIWARTISPNKNVKVFVGTPASPTAAGSGYQDPATLANELKLTRDRFPSFGGVMMWDASQAYVNNRYDLAAKNALVAAGGTGFAFPACSAPAFVSGTAYTGNSEVSYNGYIWEAKWWSQSTPSADANGDWNPISACSANGSSSPTTTSSHTSTTTSSSQSSTSSTRTTTSTSSSASPTSGGSCAGIAAWSSTAIYTNGMQVTYNGHLWTAKWWTQNETPSTGGSGVWTDDGACTSSKRSSKRAAEPARPLQNSRFFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7J2</accession>
    <name>A0A2G8S7J2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7J2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7J2"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="370" mass="40973" checksum="EDEBF9822AF4D012" modified="2018-01-31" version="1">MSTTTAPALFSPIQIGDVKLGHRVVLAPLTRYRANDAHVPTDLVVEYYKQRASVPGTLLVTEATFISPEASGMFNAPGIWNEAQIAAWKKVVDAIHEKGSYVYLQLWALGRTARPNVLHQLFPDAPYVAPSPIALSTQPDHVPRELTKDEIKQYVQWYATAAKNAVEGGGFDGVEVHGAAGYLVDQFLQDVSNKRTDEYGGSIENRARFALEVMDAIVKAVGETKAAIRLSPWMLYQDMGMADPIPQFTYLVDQLKQRHPNLAYLHLISAGVPGSIAPKDDSQAHFIHKLWAPRPLITTGGYDRESGLKLAEETGQLIGYGVLFLASPDLPSRLREDLPLNEPDFSTFFTRLEAKGYTDYPFSEEFLKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7M0</accession>
    <name>A0A2G8S7M0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7M0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7M0"/>
    <dbReference type="OrthoDB" id="2741288at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="213"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="281" mass="30734" checksum="1E1A24798C661D22" modified="2018-01-31" version="1">MWQALKKEFGTPDAAATWGNFEALIGMDRLSDQKPLRDQFNCLEARLKDITDGGLALGDNMKALLVLSKIPESYRTPISGLLTSTTLDKLTVDMVVTKTLAEENVRKTGNITSSASRVSTTKPKKKGPCGHCGGKTHNESSCWKKYPDKKPKQRGRNNGKGKGKNTSHAHTIESTDNHASVLVTTPASESSQSILASHYTAAPAVEGYNMTTWMMDSGALEHITFDINDFSIYKVFKTPMNFSTTANGTHIHGLGSGTVRGRVRVDGQWIEIKLNDIIYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Z7</accession>
    <name>A0A2G8S7Z7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Z7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7Z7"/>
    <dbReference type="OrthoDB" id="2794653at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23428">
        <property type="entry name" value="beta-trefoil_Ricin_SPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031755">
        <property type="entry name" value="Inhibitor_I66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16850">
        <property type="entry name" value="Inhibitor_I66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="16899" checksum="D9BF9B3760612E21" modified="2018-01-31" version="1">MSLESGQYIITSAFGGYGIGRRTIEDRSLMPKGIYVLPQDAESPWHVERLEDGTYKLKNKGDLVGSSIIGQLLAFLLPGGEIGATMNWTFRPDVKSGNPDAWVITEVGGHGRAWSVPDSNLHDIPHVVVKPLAVGLSEPPTFPPTEVFIFKKVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S859</accession>
    <name>A0A2G8S859_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_07846</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S859"/>
    <dbReference type="STRING" id="1077348.A0A2G8S859"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="13">
        <location>
            <begin position="41"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL29935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="479" mass="53239" checksum="1DF0829946305016" modified="2018-01-31" version="1">MMYHAESFAKNNFLTYLVGYGGSKPIPSLLASPDVSIIYLTEPPASLRRLPFIVGGPLKVLRQILEIVHTLAIRIPHPPEFILVQNPPSIPTLAIVWLVSKMRGCKVIIDWHNLGYSILALRLGESHLFVRIAKWFESFFGRSAYAHLFVTNAMRNHLVKEWNLQGQKVVLHDRPPSRFHRAEPQEIHELFQRLLPALSDPNFALSSFLPSSEPPYSTPFTRVPSESSPPASEAATLGSLSATTAMPSLRADRTALIVSSTSWTPDEDFGMLLDALKEYERRARASEGRGKEERLPKLLAIVTGKGPLKEKYMQDVRQLQTGNKEEGPWRFVRCVSLWLEADDYPLLLGSADIGVSLHSSSSALDLPMKVVDMFGCGLPVCALGFACLDELVKDGVNGLVFHNAEQLAAQLESLLRGFPSAPGLATLRASFQRKESTGSRSKGLTTGGPEWEWGTWSENWDHVMRPLLLHDVAFEAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9G7</accession>
    <name>A0A2G8S9G7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9G7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9G7"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="482"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="814" mass="91613" checksum="63B747243D82F347" modified="2018-01-31" version="1">MVPHIHLISPEILVNGVPGGPPTQEDCKKFKKPDLNPGKTEHELHQELATVVHSVFDASGCDVLRFMDHNAKGGYAKDRAPAPCEGIRTTLGHAELRSWDCIEIPFQIKMSEPHASSVYLGGELRGHEDPSQPSTPSYESTPTPYRLGDQVIRAVDDGEAAERSVVHGALSVSEAPSGEHGVGSTTRRPEALQPPRSTKLSDHVHGEEVLGYFVDYMRNLYKYQHRTFSYAVHVCYDMARLFYVDCSGILVTEPFRWDERNSLLHRFVWKVAKLANAGRLEDLGRDPTATLASGEEKDRFLALKDDMNLPQHVREGFMRAAADNYPVYKLEVAPAEPSEDEWFSDMPFPPPKEFGRPLTAQSQSSPLSELSPSGDPLQSQSPQPEARFFLVGRPYFATDELFGRCTRGYFAYDITDADSESWCVCFLKDSWRPVIPGRTRPEHLVYQRLRFYGIDRGIGTLICGGDVGGRWAQQTRIQDYLPKESRPSLRVHYRLVIKEIGIPLEDFDSFPELSAIFVDVIQAHYNAWTLARVLHGDISVANILIVPPTRDSDRRRGMLIDWDLSRLECELGTGRTSTPDRIGAWQFRSALSLLYPWKPYRRSDDLESFVHVYLFLVCRFHPTDASPLSGLVRTLFDTVSLVDGVEVGGSTKRVLFTSSRSQIRVQGNPELQELLEDIVFQCSESYSRIDFDEMRRRYGFALPSPGERSREPLTARRAPAIRFDSVDIPRSGSVRSRYLKRKAELKAARAANEASDPDPCVVQGFLSEGGDLVDLFKEHAAVELACSDKAVDHPRKRKRTYGEDHDKGAKASDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9K4</accession>
    <name>A0A2G8S9K4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6532 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9K4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9K4"/>
    <dbReference type="OrthoDB" id="2749024at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6532" evidence="2">
        <location>
            <begin position="236"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="489" mass="55724" checksum="FEBA433551E60DFA" modified="2018-01-31" version="1">MQAPPVRKKGKKANFSEDDKRRGKANKVKESEDKRRARAQGEGHGRSGEKERSRQRSEQQAHELEKREKERGKHEQVCKRRAHEEERREEKEKEKAKAKAKAEERSRNQHVRKRDDKSSDAEDERDHGRAKEQEKAKAKERNQRTTHSRGASSTVSAGRAGSSNAAKERGRPKERSSSARKGSTRRHIDEDASDALSKSSDNDNDEDPCIDIIWYGSNRPNLTDQHPRVYRVVRRTIRECEPNVCLLNAFPDEDGNFAHPVLIKHATALGYVDMTKKLKSNKETDEFYHRKLCTIASQRVNLIRGKVKKACQRQVKTVYGLAVGDSEKVSWLLDGIAYIFPHNYQVLKNHTVVGEEAFNVPIFEDMLSDAFFSKKNSFGFRIMSRFTSSDPEKPEEKEIPAAMLALVSTAIYASIEDYKHAPYEAGKFEVNSYLHVYKQNIAVLDDIKTGNLKAYHALLHGLYTCIVGDNARPVSKKTYLNVAGMAHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9V1</accession>
    <name>A0A2G8S9V1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_07217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9V1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9V1"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="317"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="455" mass="50460" checksum="B9282179CA12B12D" modified="2018-01-31" version="1">MTVTAQTTTTLGDMHDPTSAAYKKARRKHWKSTRNRSEHADADWTPFRAAEKRYKARFPPPDLSDVLDLALADPFRASEAARGGWKGCANAVECREILLHGSEEECGRKAYIFPGTPGLVLLPSFVPHHEQRRLVRWALRDHARDPNETNLDTHYLLPQDGLWSRYLRIRTGVCEDTDVLPRASQDVDPLPTPMTSEAEAPGPRKLIANDPASADNYQTLANTPKPPAPPSQSLHPAPVSSLVPKLRWANIGWYYHWGTKQYDFSRGPGEISSLVTVVCKRAVGRIPWEQVFGDTTGNEADWGPAGPDWTEWKETYEPDAGIVNFYQTKDTLMAHVDRSEICATSPLVSISLGCAAVFLIGGLTRDESPTPILLRSGDIVIMSGPACRRAYHGVPRILEGTLPPHLEGPDAIPSSPDEDDWGVYEEYLRGARINVNVRQVFPKGFDPILDGNETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA44</accession>
    <name>A0A2G8SA44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA44"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA44"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="165"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="367"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="414"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="675"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="715"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="584"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="748" mass="81757" checksum="59C87F7A109254A3" modified="2018-01-31" version="1">MSAPSLPGKTSAYVCDTIPPPRLAADKSCCSRSPSRSPSPPPVTTFDAPILVPDSDSPHLTRMDPSSTHDPGAANAHDESVPTQPPARKLCVRHQRMADEGTNLKLQQALDALPVAEREAVSVIWSNFSSSPHPRRALILHGLLTMCCFSQLSLLTEQLSHLIRIDPFAVLPREVLLKILGYLDATSLCRAAQVSRQWRSLADDDILWRGICEQHIGQKCLKCGWGLPILEKRRAPRLPTASPSPSPVSIPQPSSEGSSSASHAYLKRKLEADATDDSASPKKPKLDVHEHHSHLTTPPSSRAPSLPIPIAEPVASDSIALKNPLLAPPSSETPPPHLPTRPWKDVYCERLTIERNWRRGRCTVRTLKGHTDGVMCLQFSETLSHPTFPVLITGSYDRTARVWNLETGTEVQCLSGHTRAIRALQFDEAKLITGSMDHTMRVWNWRTGQCLKVLEGHTEGVVCLRFDSNVLASGSVDTTVKVWNFRTGECFTLRGHCDWVNAVQLWDSTGSSSSCDTSLAAFESTPSCCSGSAPHIDPGKMLFSASDDGTIRLWDLCARSCVRQFKGHVGQVQSLKLLMADEECASPTRGSDEGSDREASTEPQDRQHPQDRTNVSLSTASSCPRPTSSIGSMPTLSRQTPQERSSRQKPVLISGSLDNTIKIWDIDTGKVQRTLFGHIEGVWAVASDKLRLVSGSHDRTIKVWSREEGRCTATLVGHRGAVTCLALGEDRIVSGSDDGDIRVWCFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA98</accession>
    <name>A0A2G8SA98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA98"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="114" mass="13506" checksum="ED9439AC8FA00FC5" modified="2018-01-31" version="1">MSSGTPVLRPIRDFLRLPHQRESVLQLCSGVQRECVRPRVHPLRPALVRPCDRAQRHRQLRDRALSRSEPVHSCVRHELLVWVRRRPELSTREEQRDIIRRGLASVRHPHREGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAW9</accession>
    <name>A0A2G8SAW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP11-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAW9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAW9"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39437" checksum="00010383BA233DEC" modified="2018-01-31" version="1">MLSRHWLSTTLRESPSRGLTVSRLFSSTRLARDLASPRVSYDEKYAEKLQQRAQERGKSVSDLRAELKEQEKQRRLLKLQEESSKAPQAAQTSSASSPSPSSPSSASSSVGSSPRKDGSPVKPLSSILNLDKLLEKPHTPEQISLLWRAYHESRAGASGRGFLCATVPVESYEKMLEVAGKYPTFILPVPRENAQVEEGTKEPAYEFYLMEWGFHGPPPEPTTISDLFSTAKPSSNPQTSTILFTPLQEYKLRQSFATPYLVLTHYTDLVKSHGLVLLRGEITPSGGSAGVGAAENGVRYMLNQQDAQLLAIHVQRFYLQNEGSEERAALLKTFHEAPEQFKWEELLKHTDFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAZ2</accession>
    <name>A0A2G8SAZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAZ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAZ2"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="278"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="50955" checksum="A96A9DAB6374E0E3" modified="2018-01-31" version="1">MSPKGHRTFIVGVGCTAFSKMGLEAATKALLDAGITYDEVQAAFVGYCYGDSTTGQRALYQLGMTGIPITNVNNNCSTGSTALYNANTLVGAGLYDCVLALGFERMARGSLGTNFPDRESPTAVFGASSIQLEETLSAGENHGPGAPRMFANGAQEYFDKFGGNIDHLARIGKLGRMRIDVRLFTTTYAVVASKNHKHSVNNPYSQFRDGWSVEQVLAAPKITKQLTKFMCSPTSDGGGCCIIASEGFVHKHGLENQAIEIVAQALTTDDPTTFESNSAMNVVGYTMSKNCADQVFAQAGFKDGEGRDQVGVVELHDCFAANELLTYDALGLCEHGQAHKMVERGDNTYGGKYVVNPSGGLEAKGHPLGATGLGMHFYITMQLRQWAGPMQALGLFDVPDKRGKYGLIHNIGLGGAVVCSLLRRPEFYKEGGEDGRKRLGYNHGHECRSITRQDVDKVKAQKNSPYILQLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB23</accession>
    <name>A0A2G8SB23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB23"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB23"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="49"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="414" mass="45641" checksum="1E6FBCE5DF31B6B6" modified="2018-01-31" version="1">MPFFEPSPLSSDMLVPTPPTSDDLSNQPEEPPRVYDIYSYANKSPSTRLIYIQNAATADVAISQLKSKVLGFDLEWRPNFVKGNPENPVALVQLASEDTILLIHVSFMQAFPERLRELLLDPTIVKAGVGIQKDCKKLWADHGVDTRNCVDLSLLARTVDNARWKGKYANPIGLSRLCEAYEELTLNKGRVQTSNWEKPLDLRQQEYAANDCHAGLVLYKRLAEMAAVMSPTPHRVWYSFDTISGMLYQPSSGVLWHPFNPYYDPGPPPPPKPSKMVGIDEFPQRSIRGFRFGRSSRSLPERPLSPNAPSFVPGAKEHSPSPSPSPVPSLRTGHRSHSPFPHANDVVITAPPMLSADADGFPRLGKPVPRSAWQQQRPRSFRGGVPGPGPVHIPAARGRGRGRGGYPIAVAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC37</accession>
    <name>A0A2G8SC37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC37"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="190" mass="19447" checksum="8A250F5AD0E9AB59" modified="2018-01-31" version="1">MYGRCSLSASISRAIRSPCSDSGSGPSGDSGRGGIAIRVCVSGPSIAALDFGRKPWWRRSEHSAMNVPVRPTPAEHPATIGGSGSRSPSPSRPAGGGAMLVCAPSARSRFAPSTSFAKCSRAARSPPAGTPWSGHAAKSRCWNTTGSPAAARGAEGVRGWRRMTLCTQCAASVVCACRRVTSMGTPTTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCA4</accession>
    <name>A0A2G8SCA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCA4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCA4"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF93">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE TMT1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="243"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="779" mass="86590" checksum="AF0E38DED5886835" modified="2018-01-31" version="1">MDSAIIFPVSSRVVTPGAPFDDPNPDPSTADTPCPMLSSAHALSDPALFDAYIAGMVAKGSHHSHHWPMPPTPTPTSSERSSMEDDVRLDESPSQATITQAALRAEAALKLKKKRSFGQALKALKTSSLDFTETWRGTKRVPLPLQLEDMSAANVSTHPHLHSTRPAGPRRTEEDHGFEDRNRTVRRRNMPHHPFSLEDAPYMQAYSQVLLENDYQTHQLLSKLMRADSPTFHNFGKKPPADVLDLGCGEGFWVLHAAKLWKSNNTRVVGLDLIDTHNNEAGEVHPHLEPVQSPKNVAWERANFVKHPLPFPDNSFDLVRMANLTLCIPVNRWRFVLTQVRRVLRPGGRLELIDDDLFFPTILPRPSRDVPRSPSSKRQWQRAVSADHVFGPSPSTKSSSLPDKPLPELPSPQRSPGRTRSHTHTRTPSDVEFSVNTAIATHLETIFQNMLVNNYDIAARPHAFLEHMLRDVFGQSCARRTQTLELAVPSRELSEGHENPGPGLGGGRRSPSRPSTAQSAHSTSTFTHAKRPSDDDSKRSKYPTWSRAGAAASCLNLPLAAAVPLPRSQSQRTSDETLDPRVLESLTPKARQLLLGDANTLDSRTTSWKAMGPYQPPGLVLLPSTLIPCTPLELEMHACKHMNTLLGCKDALSKYVSTQKDNDGKLFVSEREFGDFLWDYECFRRKRFNWPLDVPGLQVESDADEPAPPSPPSANRTIFKFNTGTYQEPKRTASIDGLRAARMFGGISATKQSSTHVRTIRVYEALKTTHQCTCQCGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCY5</accession>
    <name>A0A2G8SCY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCY5"/>
    <dbReference type="OrthoDB" id="3060996at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="405" mass="45918" checksum="2CC8A9EB1301DC5B" modified="2018-01-31" version="1">MPLSETQVIELHELLSAARLLRTLKLGQIVTDPFVKDASSLSTRTLRQLEELQMYVDHPGFTAYVSSQWELPVLTSFTMVYCEALPETLLKQHGRNLTYLHIFPKKKDRVYDYSWVACSVDSLDVLSEWCPVLDHFVFPSTRPNYHADTILSRIRSSSLRYLDIWCHDCLATRELVEVEADDAVELGHLPSLVRLRRLRKVPRIDLPLICHPSLVTGDDFRLYHLPGLFVVQTSWCVVPDSGLQGDLPWFVHLPPEEDDSKTFIQESESGEEDEDGEGDGDEEDEEDNDSESDDDSDDEDEDEEDEASDNEIESDSSSGTEDSEAQISDWELDIPALKEARLKEAFDRDTILGMFAASQERNVDQRSDGSEEPEGEGVGREDAESRMSVSPPVREEGPSWLPIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD59</accession>
    <name>A0A2G8SD59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein mS35 mitochondrial conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD59"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD59"/>
    <dbReference type="OrthoDB" id="283424at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="103"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="272" mass="30066" checksum="2597360A8ED9780C" modified="2018-01-31" version="1">MALSRPCRAAFAPVFRAKRFHTGPVLAARQSAGTAVAAAPKARRVVPNLEPLEYDEEALADQVREGDDAPEPTHRYLQQQREMLYYLRLIEHEMPKLVAYRRPFVPPNSSNPLVIRSISYGGEPHPAAAKSTIVVPVARLPLKNEQAIHKFKVLAGVRWSPEPPTDSGLTTEEGGAEHGYFKVSCEDFPKAPMNLKWASDTLDRLLGAANDLTETFADIPVDTRHIEARTRKAKKGGHIYGRQTHRPTLSDFPKEWLPVPKPQAAAEASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDX6</accession>
    <name>A0A2G8SDX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDX6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDX6"/>
    <dbReference type="OrthoDB" id="2536675at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28288" checksum="51D56E3FBC7366C3" modified="2018-01-31" version="1">MGSVPGFQVPVERSMCTLTMDDNVFCVIEDPAAPMRADYLQQAAEYARAHPGMTLTPPTHFRHTFPTLSPPAALEQLLTQLRARWVSVRQTGSSTAAAGPSGQKGVGMGTGPHVTVDGHVYAIGSDWLVRAGNVHLAGGAVKGMLLEVEYMPLPVMEAALDMPPVLANLLLSVLPNVPDPKLAAITLAEWQWEELQWDTEEDLEREAERKKEQEAEDDIYASEQDQPSLCKGDWIGMDRDRRSAYLIIQTLKQENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE07</accession>
    <name>A0A2G8SE07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SE07"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="1146"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="781"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="913"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1476"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="289"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="915"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1043"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1092"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL32005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1505" mass="163289" checksum="0FA5D3E1D7FF8EBA" modified="2018-01-31" version="1">MAGRRLTISSLLCADDQSPDRSQPPATPSQSALHPPVLSGPGIPSPTELRDLQDRGFLDSQWDPSRSRLFSEYTQDSHAAVPLALQPVHLRRHTPSPTLDDAVTHSHRRRRYTDDALGHSEALASRALHSHVSREHDTASNPHHSSHHLPQSAPRPIPSSRRSSDPHRVEYRLPEGSSYFPPTLSRSAQSESLAVSPYPPALHHSLSHSPLQPSPPPYQAQVSRRPSQSPVLGLRPAFDSLSNTSRPLSQPSPYGNHHPPSFVAAAPSQSQSPPSLSTSPSRERLPSRASHNPSTSFSQADVTSMASRSSVAAALNNLLNAEPTRSPAVPIGARGSPGGLGGLEALVQAATEERRRISGEHPTPLEARESARRTSLSPVLNRAPPPLPRPSQSPVLQKSPMVSSPRDTRVNSLAVISLGHDGEPPTKKRRRTGSFGSSASRMPPVPLPPKAPPTSTPNFPSPPAPPHEQADRQPAEPTTPVTSRPAVPFTKPRSIAQLLSPGPPPKGPTFGSQSASKPQSPSPPVPPSQLRSLPVDDLQPQPIPPAEQGADVETVIVIPEGRVVECEEEPEPAASEEQRAQAQRAEAEVEAVELEPRIAVMEELSIHPAEEDAQDVSVFPPPMVQEKAVLLSIEVEKEVVVPLIEAEEEAIVPPIEVEEETAVPLVEAEAPQVVAHAPSLLGPTANVTEEFTAARTAVEESEQLAASPITMVVEELTSSSEAMAEEMSRPTTGPTLVSEAVHDFESELIREVLPEPQHSEPMHTDDAHEWLLEHYASPVTSSRHLSAAPEEPPQTPDFSDAPSPPPLRESAEEVPKGASSPPPGLPLEPSRRPKKAPSPSRSPTPTALLEQELDGIVADGLPASAPSPRSDMDMDFALELDLAASATLDAGTVPDISMGNDFDDELLSLLDDKPHHHHSHSHSHSRSHFHPHTHSQSHSHHVVIGKASQPGPSVATIEKELPPKEPVDKNPSSSPVRAASNAPAPSERVVMPPPVAPPQIAKQATPQVSAKADKPSDGTSLPTSASTKKKEPTAKQPVPKPKQLAKPKPKPQPKSKVKLAKEKEGTAEPSGRLTPSSNGMMAKNKKPPPPSVTSAAAAAKRAVSAATGPSRSRSASEMPMPTEPAAKSKTQPQEEEESEDEAIDDKLYCICKTNYDEDKVMIACDRCDEWYHTQCLDMDDLEVDLIDQFVCPLCIKANPILPLKTTYKQRCIAGLKHPHPTSAAACHKPARGAFSKFCSDECGVLYMQRRIQDWGGSKEALWASIRDTKQREGVVVKVHVNGGHNEVVADDKQAGRPVHIVAQESYEVRRAAHTQRDRAIVRLQAELDKIAPKREELKQEHDVISWRQKVLELAAARADRVDECGWDQRLIFDEEEYLEFGEGVLESYEERSPQPNGAVEESMQVDGTYGHGEWWCRGKKKCQRHAGWQKLRASEIECDLTMNRKSMQEVTNQEREIRKKLEDTMSIPLRTVVPGSFQPLNGHHFTNGIKSKPNGTSGKKGKQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE96</accession>
    <name>A0A2G8SE96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE96"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE96"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="520" mass="56895" checksum="F4662AF9110BA7C3" modified="2018-01-31" version="1">MPPSDSSSTNDLSGSGLDSDSSLSRNSCIEEAQIPTDPDALSRADLTKALRAVQLENGKLRAQIKKVEEKNAVLKAALKREGKTEAQAQKAAAQRLPKGVDEHQVSMYGKKFAAMYKPWIEPHEHCRHRATDLDPFDPARFKDPEVQRTAVAAELQRVVFQDHHELLRKHLGFQTVLTKGMGATRSTSASTKVAKKAAQIFSLPPRYWENKCDRSQVPELIRLFTVSLAGFPPVLYTDFKPKPKNFLISIPLTMIGRSILFGGGSLDVKPSRTAKMNTALWDIYEVTEGFIAFIAILAIWAVSGDPHFVPTGEKTKFNYQDMHTKIKGFLIQTSNSDMTKKIMAYHQHWIFSSVSSGTHAQSASAASNATPAADSQVDPVDSLIAKVNSSFVFSDSEDEATTPSHAVPPGREDDGAEDRADQGIIAQSSLSTTRSASTRASPDARPETDPSSSSAAARKSKDLEKPPSARPARAKTTTTPAPAPVQVQDDMAAPEHEEEEPQPRRSRNATNKRKNLKNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEC6</accession>
    <name>A0A2G8SEC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEC6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="14456" checksum="903E44F4A0F9E0E5" modified="2018-01-31" version="1">MSVTPHPPHKSLAVDQASTIVPQDPSSHSQNSSFSTDRPSTPKNENFVDQADKAPIAGVANTVAGINEPEQKGSGRLIEGNGLDREPVEPEEDEDDDDDDDDDDDDDDDDDFIPRGGPNRPTGAGASGNPKPVRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF32</accession>
    <name>A0A2G8SF32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05609</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF32"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF32"/>
    <dbReference type="OrthoDB" id="3350428at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052260">
        <property type="entry name" value="Autophagy_Rcpt_SigReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090">
        <property type="entry name" value="SEQUESTOSOME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15090:SF8">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="195"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="284" mass="31351" checksum="AC861FFE329637F5" modified="2018-01-31" version="1">MDASKTGTNWGAVNSSIDFPPAYDAPRGAWPLESHPGVRAGGTVICGFCGKHVRDGNRFKCLQCPSYERCGECMSAPRAWASHDAAHQFFPIRNPEDETYFSQVRSMVQRSVGTRAPRLSHKNINCDGCGKTDIEGVRHKCLVCDDYDLCEVCIASPAKRTEHNPDHAFFPLTTPYDRHEYDKARARAHPESILHDGIACDGCSSKPLAGVRHKCLECEDFDLCTSCVSTPSRLMRHDATHAFFPIDVPGDKTSFVQAQARRKTASRRPRTETVLFGGPGGYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFE0</accession>
    <name>A0A2G8SFE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFE0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="10945" checksum="A5CBDFD570F11B67" modified="2018-01-31" version="1">MIDVLILHSFSKGGLVEDSEMKLYGSSTVVGSTIIYPGRIASPRSMGQDPEASGSTETMESNDEHFRPGDQGIRRRWKLCAPALVRVVATVTLVVCKLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFL9</accession>
    <name>A0A2G8SFL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFL9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFL9"/>
    <dbReference type="OrthoDB" id="5122891at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="42"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="277"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="767" mass="86139" checksum="9F5148552886322C" modified="2018-01-31" version="1">MQPVTIQTYCQETGGREMRQQGTRPERTGEFKWVEDPRQEHFAILSHVWAKDGDSDYPEQTYQDLLRFQEESRCADPAAGTLPISKFSDKLRRFCEIALKDGFEFGWADTCCIDKTSSSELSEAINSMYSWYAYSSACYAFLHDVDPPSEDSPKWQATFTGSQWFKRGWTLQELIASRIVIFVSKAPGADGDPARARPRIPGWEVLGSKHTLAACISSETGIDVAVLTFEKSLGDIPIARRMAWAQSRETSRLEDEAYCLMGIFGVNMQTNYGEGQYAFIRLQKQILSQSPDQTIFAWGRFLDDPSSVLLPSSPSSTKTPDNASTDLSHNPIAPPSFLEQYLLAPSPKHFDRKHSASMVRLSQEVFQQRLGISITDALYQVFEITPYGLKTHFPLLNVCSSGHHMTSATHCAILSCEDPDKGLLALLLRPRKHLTGNEFFVGAIVRSIGQKSGADEPFGRDRVWDDYCRLMYVTVDQLNDLRKSATSIFTLYRPRDLPTASSVYIPHCATRSAIELVRDSNVHAVPREMSERFEVLFCRWSKKPPHWQDSDVEPPFATSKSVLDRSSSSPDNAIKIWNAEAKVELIIQVARCKCDFGQRTGALGVLVSSTDPESLDKQFSMQAHPIDHRIHVHSWSFDHGFASREIEFDSPKDSVRRLSLRLTFTSIASQRASDGTTVRRCRLGAELRERGHAELQYPRQPLPLNPLHPIPNSPLPPLPLDLPGDKQLLRATEGGVNNGRVNERHLVDKGRVQTGDEGSITAYTGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFN2</accession>
    <name>A0A2G8SFN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFN2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFN2"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="33"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="523" mass="57408" checksum="6D1268F92F62F2DB" modified="2018-01-31" version="1">MRDNRSVTPPPPQMPSSSYLSLSEQEPSRVDEPATSRKLLVLDLNGTLLHRAPHTFRPKSRTATVDSRKRDRHSNFLPRLRPVHPRPYMPAFRNYLFHSRTKEWLDVMVWSSAQPHSVGDMVDKCFEEHKDDLLAVWARDTLGLSNDHYFRKVQTVKDLAKPWSLLSPKPTDTLPSPHNSIASTPHTSPEPSSPLRRNNDSIRPAVDASPQAHSALTTLLLDDSPRKAELQPFNHVCIGEYSGEKRVKDLENLQKEQDLAAARGQVDAYIVESETVDATTAATVAATTITAGSGSEQATAADADVGQGESSKKRKRKEKKLQKRAALLEQMSNGEGKPTVIYDETLLAVIGVLGEIKSQANVAAWIRAGGLWGSHGPPASASESQKVEVVATTATTLPTSSKVTLDVLDAKAEDKAAAESDDSTLSAEEAKAGKRKKKRARVRGPTPVLVGDIERSGDVVAVGNDEVTAVPMSSLPVSETVAEPEIEEQKMWFEHADVFAYWAERGRKMLEELDIPVEHGIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGE2</accession>
    <name>A0A2G8SGE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGE2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="111" mass="12164" checksum="A3C4DA0EBE0A6C15" modified="2018-01-31" version="1">MSITDEFLCVLFHPPATSPPYPQSPAVDLFRRRSTARLWTGHPNSWTRSKQCASTRRARGEGTTIAKDISRAQLGETQGAGGATQQCVESRTAINTHILVREARAQGKAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGJ7</accession>
    <name>A0A2G8SGJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGJ7"/>
    <dbReference type="OrthoDB" id="2751407at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="242" mass="26313" checksum="543A62B3ECBB41CD" modified="2018-01-31" version="1">MLNGGLSFIAGSSIISFVQWEVYALLRLVMHHLLDLDPLTFREADLMLKSVLKCSSTPDTTDPTPLIRAFSALATILHVTLDDCDQRARGLITAIRSHPLKTISIHLAQPEGAGRRNPIALLANLSETLEEITATNAALALDDTIYDIFPSVRQLSMTGVLPADLGHTTNKAALTPRGPSWTHLEGLVGVFPYVFILSLLTCQVANLRHNGQSLYALMALTDLLEDAWPANLAVILVGTHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGP1</accession>
    <name>A0A2G8SGP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGP1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGP1"/>
    <dbReference type="OrthoDB" id="3158970at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="725" mass="82398" checksum="3A2C5D6DEFBFCC5B" modified="2018-01-31" version="1">MASSTLTVLDVGLDSPNTLPDTVGNDAHIAMHSLKGKAARSWQDLPAEIVRHVSHVAYWLIVNYYLLDLSANAYIPKTWEPRELWPQRLAFTTFRDAVQMAHLRKLVPWWKHHLENHAFWNKAVAILDPMGVYNHLTVIQPTATAGSNCAVAQRVPMQHHFNNMLAVSCLVCRVNCPYNSEGLCVGSEKHRSITSWFGQIRACKEHQKSASFCGVCLREAPRIELEEDYAQGMPVCCVENEDDETWPKVEATCRTCRAEYFWRRVSMRPEWQIAVDQRLGPGLDWETRQSMESFIDLGEGIIREVLQLAEEKHWLRSYTKISDMLQQALAASRFTSRVEAGEAYGSDEELSEDEMEDPEMMSLTEDAGGVRELAINDWVRNRILDGHWISPADDFYNNTEYGHHRLAPARHPCPWNRRAIYEGALEDGQGDEAQELPHPRPKTHNVPHPPTFHLAQQTYYAFQRQMREILFPPMRNLVRKFVMEATFDGSDAAMRAHNTTIEEIVNELRDESVWYNGVDWFEVRQNRLALEEEERRRIHEQEKERDEDDSSSSSRSGGSHTTSPVLSTTTLQTTPSPPPVNKDDDAAAVVSPISGVPPAAPLHFSHLHSPSLRPSELLRPIPYVPIMTEHMPHYSREALSVVWKEACAPLWQCQCSICERAMMNANMAASETVPTQAQLAQGQQQPPSTQQWSWMVARAGARRGAGRRAEGGGERWVPLMGGEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGV9</accession>
    <name>A0A2G8SGV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyoxalase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGV9"/>
    <dbReference type="OrthoDB" id="408973at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="291" mass="30836" checksum="1297F4F45551CAE2" modified="2018-01-31" version="1">MAGPSTRILDHIVHLTPPGTLEDAVSSFQNLGFTVSPGGTHAGGKTANALVVFGDGTYLELIHFTSPPPNDDPNPWAHKQPGWIDFAFLGNGGVPSIAGTINARADADGSGAHYAAEVQGGRTREDGKVLEWLISAPPGGERGELPFFCGDLTPREWRVPLEPRSNVRHSNTARGVAHVKLLIPPEDLTATANKLTSVLGISPFSSIPGEVAWHLGPQLSRPDPAPTSSIPVLKLRAAEGEEEMEYVRRMRGPGIYEVGFIVSDPSQGRGARTPYGRVVWVSAGSESGSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI74</accession>
    <name>A0A2G8SI74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_04086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI74"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI74"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="197" mass="23084" checksum="1D1C83AE33735450" modified="2018-01-31" version="1">MMSSSDPEASATPFQPLAAHFAKAQRQYQQWLDKVTPFVLYRWIGTAVLLALFMLRIVVAQGWYIVCYAHAIYLLNLFLAFLQPRFDPSLQDDLLADEIEEGGESTSPLPSSRDDEFRPFVRRLPEWQFWLSATRATVASIFASFFEMFDVPVYWPILVVYFFVLFLLTMRRQIQHMIKYKYVPFDIGRKARYGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIB5</accession>
    <name>A0A2G8SIB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIB5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIB5"/>
    <dbReference type="OrthoDB" id="2803809at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="189"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="873" mass="98677" checksum="448986440AC0823E" modified="2018-01-31" version="1">MADPNANASDQPHLSVPPQPPLKASPNKRNHTATHYSAIAQQLAEEQRKGHRLSMDGKIVVIDYETMMNDHVPSPEHEPDDMDFQSSFKFKFNFKSKVASESKFYEPFANAINNGWLKGTNFKVIVTSATPDPSDPSKQRVDLAIYTVDSAPVDGDPANWSAIELSIEVKLEEVSDDPFDEDAVTFQPSSTERKNNLGQVLSYSSLLFEHQQRTHQFTLVILGQCARIVRWDRAGALVSEKFNYVEQPWMLGRFLWRFARMSAAQRGHDTTATRVLTTSDEYRLMRERADVPQKNAEGFVINEHARLLFKESVRNSSAQWWKLRVDDSTDPRFFLVGEPHFQASGLSGRATRGYVAVDLADPRGALVFLKDAWRVAHAGIEREGNILRYLNEKAVNRVPTLVCHGDVRARKDERAGEDDVDVEDGHIDEDDEDHMETDSEDEGTGVNDEEPRGRIQQTISQKYWTARETGAHCPMKTHRHYRVVVREVGLPMSHFKNAKELVYLLARGISAHDQAYQAGILHRDISAGNVLIQVKEVVKDGKLVRFRDVLLTDWELSKRLDQSDTEPRQPDRTGTWQFMSANALSNPWRVITVEDEMESFFHLLLFYAIRYLPHNCKDVGMFMEEYFDGFTKENGQYFCGLAKWAAVKGGSITLPNQAVQLTFYLPAEPRDENNPGPSSAPLNDGNAPLPADRSSAAERKPHPINVVFDCMLEWLHAQYSLINEKMNPTAGPHAAAPPPPDHEEQVEEGPTEEEMWFVDEYNVDFNDPARKKGTVYSERAKLEELAANLKEHKHVVSLFGRVWSGKALDSELGRWPLNDKVPDQLRADFRPDKDPELGPALGSKRASLHDGRAAASEVPQPAKRRSTRNSHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJB8</accession>
    <name>A0A2G8SJB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJB8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJB8"/>
    <dbReference type="OrthoDB" id="272162at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Autophagy protein ATG5 UblA" evidence="7">
        <location>
            <begin position="27"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy protein ATG5 alpha-helical bundle region" evidence="6">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL33851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="203" mass="23465" checksum="518F4301ECF14230" modified="2018-01-31" version="1">MSTYAPRHSPSVFSTPAATTLFRRLTWEGTVPLEVRVDPKELPANSDRGLECYYIQAPRVSYLPLLVPEIKRFLMDVVFDEAAARVIKEEDWWFESEEGSLLKWHWPIGLIYDNHIITLSARHNAPPSFFTPLRITLHLASPPTEKLLLAPNAEACKQAFMGQLKEADFIRWGNTKRMTGLRKAEQDGLWEGIKEREYHFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLR1</accession>
    <name>A0A2G8SLR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLR1"/>
    <dbReference type="OrthoDB" id="10519589at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="317"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="828"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1012"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1075" mass="117129" checksum="32161F69DF467EF1" modified="2018-01-31" version="1">MAPTTRKSAKVVPLHVHASLAHLRACPQCGFRAGAPLMSEGISNEENQGCWYETCLNNRPPRYSTCNYFAWRKDIPEGRPANTETRSCPGLLCTSRADAVNRVPSAVVQDQRPFYRHYTPINAFCTSAKASGPSSDEEPELDPDLYADPDVVSPALDTSRPSVALSIGPYYRAALNESEQQQRLQAELADTEARHERARAKRHETSLRWWNENDELPQSLVVPVPRWPEFHPPDIPLLAQEFLSGDNRFQYWEAKEATWYTGSTGTAPRDLRKLSKDDLCYRSWDVKRGIGMPGQQVRCHMPEDFVPSASSLDPMPYLMTPRAHTRFSSPTPTSPPGSGSSAVSWFDETPTRPPSRSESDLPEINESLTPSEDPLPALFPSEHVPAFPTPSSSSTSPLDLSSAPRGPRGWPWRYALHVQPSESRLFPLPPRRSPSTSLSLHVALALPPPTMASSTTRSIMPSTFWDNLTAEILKLLVPLWTGSKSGSNKAAWSSALVDAGGSIDWARIDRWTNYNLGDPGENPEEDVDMRGWLMDRCMYLHIQSGKLTFAKHLKGLDMATGTYLPNDVSQPSNAGSAPQPSDLDDPMPDPANATQSARAPMVGPSVTGATAPADGPSTAGVGADSDVVPVTEPAAPSTHVDPASVRQKIAALLNMTTGNAESDCALLGQCIDAVGFKTKDDNEPVWLNTGLPARKNGRLHAKSDVALYGVDARPDPLHPRGKMVFVIMKQADLRYVPEFRAVVVKSPDVFEALAADVRFQQGNVCFTVPVAVHGAVLEFAVGAIDSDKEAHTNEGFHLHTIPLNPDMSSPSFRNIRFGVQFRADRHEDGELPSTSDVLTEDDESGRDQGASASAHVSRGKKGNLALDVAQLQWLCATNDGAFLNNAAVKLLRSTHAKSKFPYASVVTIAHTIFDIAKVGWLPDTAPVLARGTKIRYSAIGRLVGRSAGWVGLAVKLHEQLEAYKADPDVSWRLRKRRNGLVGVKTLLKEIKLAVEGDEAMDEDDGDGRPEEDKDEDGEGVDGLENEDEDDDEDGDGVDGQDDEDEDDHGSYSAEMPPGGVNYGARVLSESEESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM29</accession>
    <name>A0A2G8SM29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_02623</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM29"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM29"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="304"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL34836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="407" mass="42929" checksum="71465D164180570B" modified="2018-01-31" version="1">MSSHPSTEPRIAIIGGGLGGLALLLTLHRRGIPATVYERDAAFDARAHLGGSLDLGWKSGQRALRENGLQDAFDANSRPEGEEMRIYDATGKVHFKHGGEDDPPQAKEAIRPEIDRTVLRKLLLDVVPAHLVQWGHTLSSVRSLGDGQHELTFANGLTTICDLLVGADGAHSRVRPLLSSATPEFLGVNGAEISLTPEAAKLPQLAQTIANIGKGGMMALADSHMLGVQVNGDGRIRTYAWLRAPASWALPSDPVAAKAALKEEFAGWAEGLLNLIDYCDESAIYPRALWSLPVGHKWAHVPGVTILGDAAHLMSPFAGAGANLALLDGLELGLALASLKEEGKLGEVGAPMSEVVRGFEENMCAMAGRVAAKANRTLEVCVGPGTPQAAIKRFGELAAASNGEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM34</accession>
    <name>A0A2G8SM34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03417</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM34"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM34"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="132" mass="14015" checksum="125D0CD69D1AB4E1" modified="2018-01-31" version="1">MFDAARDNNAELLLQAVDVGLPVNLTNDKGNTLLMLAAYNGHASLVSELLTRGADGNRLNDQGQSPLAGAVFKGHDEVVRALVEGGRTDPRIGTPTAIQTARMFKKDELLKVMGATDDDFKDPVPGIPGPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM78</accession>
    <name>A0A2G8SM78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_02662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM78"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM78"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="600"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="71"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="468"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL34875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="666" mass="73057" checksum="63F0700B3C603DB8" modified="2018-01-31" version="1">MNVNANATATDLRERHKPKLPEPDALPKQVRIEVPSPARQRLQQQRERILQFQQRWERIKTDLPPQLSRKHIGMISIGGVIGTGLFLGSADALLNGGPVGAFLGYAVVGTVVYCLCVSVGEMIAFLPNVGGVVGLADLYVDPALGFSLGWAAWYNWSVTLRKTATEITAAAVVIGFWKEDIAKGIVSAISAVFLIIATTINCFPSRVYGQMEYYLSCMKVLTIVCIVLLGLLIDLGASHEGVIGFRNWKKQPFADTYLGIGGAKGQFLGFWAVIMQASFSFFGSEVPGIAAGEVIDATRNVPRALRKVWIRITLFYVGGITISGLLVPQNDPRLGLGDKGDKTGRSAPFVIAFKRAGWAVLPDVVNAAILLSAWSAAASDIYISSRFLFFLARRGHAPNFLAHLFRYPRARAVHSPHSDSDSDSDADSDSDADSEIAEVGRDEVVGLSDAELAGEQVLPSSQPAYVMPLASVLVSASVGLLTFLSYGAGSANTVFNWLVNVASVASLQSWAGMLFTYIRWHQGTVYCERKWRGDDSPEGREAIAQIEKIKRNRNWGQPYLAWYAFGLCMLVLFTNGWAVFVNNGWRIADTLGDSPPSKDVVSQFLSAYVPLPFFLLLTFGYKLIKQTEMIPLEKMTFYQGQLPPYNPEDNEPKGWLEKLLAWLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMI8</accession>
    <name>A0A2G8SMI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMI8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMI8"/>
    <dbReference type="OrthoDB" id="2766701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="460" mass="51070" checksum="0766F1A367C0304B" modified="2018-01-31" version="1">MRKLRRNAVIPGERPSSAVYGRYEGGGSEPLKFLSIFTPGSPQAEIPSTACLLPVTGRVVKKWAIDDAQDLLVTVEWSNVPNSDPTLPKREEVFFYSLSGSKTARTPHPAATVPSLVVFPPDGVAPTESIHIFKLCIAREYVVIEPYVSAVNYHSLDVWNWMTGQFIKRIEVPGRSLVNFVPLDGIYVLVIMRYSALCVDIYALAQSAPNHPICALEFPQDVTSKFPFSCQIATGDRPVSSPGHFRADPSLSIVSVALYTEDIQYEYASIFLIPHATLLAHIRKAESRQLQEDHTTEPGGAVVRVPWADWGPCGCLRLRLQQCPHHSSHMSLFPSGSRAPVVPFQVSKIWERIDSFFVFELNPLAARLAKQRLRARGRDQPPSELEDTAMVEDVEAALPGVVDPECSAIPYVVYRFKIPGSSTNWHSTGQTIRAVEMSMTGFTVQFDGVDFEESLQTWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMM8</accession>
    <name>A0A2G8SMM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMM8"/>
    <dbReference type="OrthoDB" id="2757550at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21075">
        <property type="entry name" value="DBD_XPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="129" mass="14784" checksum="30A0142BF8D82A9E" modified="2018-01-31" version="1">MQSAKQVPSRLGPTPDNSSASWRESKVPEDAVISKSMAFKQYRLKPEDLDGIPFDIKPGQLGGYPCDRYLYNERDVERKAWERHGGPEGFDAYLSVLRNRYNTRTRKPGKWTPFRQPKSYDNDGDAVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMN3</accession>
    <name>A0A2G8SMN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_02770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMN3"/>
    <dbReference type="OrthoDB" id="2734679at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08999">
        <property type="entry name" value="GH43_ABN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF5">
        <property type="entry name" value="ENDO-ARABINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708304" description="Transporter" evidence="7">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33599" checksum="2610516003AE25F8" modified="2018-01-31" version="1">MMFPAALLTLLGAVTTLSLATPVKRTVSHGAVINRDFPDPGLMRNSDGVWYAYSTSSRSGLVPMAKSTDFKTWSTPTNVLTGVGPWATGAVWAPDVREINPTSYVMYYTARRKTGPGNDHCIGVATATHPAGPFHPRASPLICDLAHGGVIDASGFQGPGGARYVLWKVDGNSAGKPTPIKIQHVGADGVTLQGTPMTLITNDPVDGGLVEAPSMIYWDGWFYLFFSSNSYNSLKYDISYAVSRSAVGPFKKVHAPNAPFLVSGKFGTAGPGGATAINVLNKYVNIAFHSDINGKDASGGRAMWAISNVCLGNGVAKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMP0</accession>
    <name>A0A2G8SMP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMP0"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="592" mass="62310" checksum="52A05C88C7D1E566" modified="2018-01-31" version="1">MLTPSVNSPGNSPPTRFKCLLGATPGLLDPAQVARVLRAPDSTLSFAILDPDPLERAAHGASTEADGKHRIAIEERSAGAGTIRYRLVPNAELASGVEHERMTWPRVVKIGGQFTVCSKEQWYIYKLDPAYSCYVPPAPHPPMISRREPDSRNSNRKRPHSNDPAEVEDLSKRFRKNLSFSYGDGAEPVDAQTTSGFGPEGGLSEGIQVDGSSQDHGAASPSTSVKDDMEITSDDIPGSSPCSNQEHAPTGTAEPASAPPCSTDPGSSSHPSIPPNGASPVGGSTGIAGHPTEGRQTEDPSATYSAQPPSETVDLTMENAPSTNNAESSTNGHSTRAATSSTTQPEIVDLTMEDEAEDSPTEVTADDFGMEDAAEDFTMQDEDFTMQDAPKGPPTYGAKRKGDTSQPTSPPKRARTTHKPRMSAAEKRAAERTAKRRTARLAEKERLKKEEREDGEDSLWTDILNTTPNRSSTSTPHGTTSSRSAPCTSATSNLHAVPSTGPSSGAASSTASSTASSTASSTASSTASSSASSCSNPSTPSAASSSTAFSAWSSTLPTSTLNDEATSEDLEHKAYIEASRRKMAELEKDKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN35</accession>
    <name>A0A2G8SN35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN35"/>
    <dbReference type="OrthoDB" id="10621570at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="157" mass="17270" checksum="EE2571C5B3CFC24D" modified="2018-01-31" version="1">MQRPSSPDFRPNAANDDDTNTSTCSATELSTTSYTRAYTTNDLVAVVRHLPPRPISEEERSPGLPVHSSNPDVARMILDDTSSDSPLHIHITPTIRRNNTDIAIIDVAASATTASHPGIDHVRAFWEEVADDVGYNYAFLLSLSIARVLERRARALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN62</accession>
    <name>A0A2G8SN62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02994</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN62"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN62"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="642" mass="72679" checksum="C2589F262A52A8E4" modified="2018-01-31" version="1">MLIAFISLSAEIASKRDPTVEACDYDAAPKRRGRDKVPGSREILHGFDPATFDPENVAIYELPARPPCNPSEDEDTTRKEKERSVYDLIADVPSMQFARETWWDALLEFYATDGAIGGMTLTADQRLATTKRVFADIRAVLNASMYWASFLHLPRFFETFLDPKRRSSVQPSLILSMLAIGVHAQSSEIMHGAKGRARAQKLIDLADSAIKASLSTNWVDIGLVQAAWFITYFEMQGHAQQQSYRCEGSIQLLDSLIRLLSLTTLDADRLEAHYSIFATSSSNIVGQSMFNDPAGAHADAHPPAPSERNRALENVVIPKPGASIEGPAQCDCLKYTLKEQWPTVSEVAPLWEMTTMWPNGLMEGEIRKEECRRLVWSSVMLSAGQNAYAAADGELDRTELFIKDYRNLAILFPGEDIMFSSNGQISPSNVWTLCIRSMMLWHTSTRQRGNTALSPQARAEYSINAWLEADAIEAALDMHTCQLEGAQLYQTREFLFALYAPQVTSLGIMSYYREKAESWLRIQMQVSEYLWKASQEEEKWEMMNRPLLSYWFMGHIVRALLLYKSDPTLLIALDAVKMHIKPLEFLMRLWPYDDQRQKWASLRREVVQTCLKAGVPPPPTDVPIPFDRVRRKTFPSLPAPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNW9</accession>
    <name>A0A2G8SNW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNW9"/>
    <dbReference type="OrthoDB" id="3238099at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="238" mass="26996" checksum="18CDDED771049D31" modified="2018-01-31" version="1">MMAEKELTAIFRAHPHALPNLHAFKLSSSDYHSDDIAALAEFLRPKRHLHLLDVTVTSRWIGSDPHLCPALPLSQLMSALPDLRVVGLGFNFRAAQQHTISYMERYLPRNLTALLLWRGSSSRPDSSSKPWINLFAGYKSLRYLHISPGKDDEIDLQADILRSPPPSLELFGYGRQIHPIGRDLATGAAVVRPRWPYPKVYFRTADDFGNAGWEWLLRHHGDGGVGHWNFMRDADSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP17</accession>
    <name>A0A2G8SP17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02245</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP17"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP17"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="168"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="770" mass="88007" checksum="D3FB466C2B2745BE" modified="2018-01-31" version="1">MSYSDYPSSPQSPGGMSARRLTNRNTNRYSVTALFSMAAEQDVEVEDELGRAQKRLRDLKSRISAQSKRNFVLERDVRFLDSRIGLLIQNRMALDEQNEVEKHLEEVDATEGHYPDDRKLQQYSNLFFLLQSEPRHIAALCRLVSLTEIDTLLQTVMFTLYGNQYESREEHLLLTMFQSVLSSQFETATEFGSLLRANTPVSRMMTTYTRRGPGQSYLKSVLAERINSLIEHKDLNLEINPVKVYEQMIQQIEEETGSLPPNLPRGVPPEVAAANADVQAIIAPRLTMLMEIANSFLLTIMESMESVPYGIRWICKQIRSLTRRKYPDATDYAICSLIGGFFFLRFINPAIVTPQAYMLVEGVPAKHPRRTLTLIAKMLQNLANKPSYAKEAYMITLNPFVENNKARINQFLNNLCEVGDFYDTLEMDQYMALSKKDLIINITLNELYNTHSLILQHIEVLSPNDKQHLRILTDELGAAPPQVPRKENRTIELPLYSRWETPVQDILMDSVSPSDMLYMEAKSIFVQLIRSIPGLAEKRPHNLAQIAERAATTKDATLVRKGIKVKEMLRELEEQKIVDRADGYKLMQDEVAAELVHLGNLREKVLLETKSLEAVYKTICDHNNYLRSQLEQYKAYLQNVRLTASKEKGQSTGVGVVTVGGKEKKPAKPVVHGPYRFTHAQLEKEGIIVESNVPDNRRPNIYFNFTSPTPGTFIIALHYKGREKAILEMDLNIDDLLEKQKDNKHLLDLEYVQLNVPKVLGLLNKIFTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSF2</accession>
    <name>A0A2G8SSF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSF2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSF2"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="122" mass="13437" checksum="210BCFA2C29B76FE" modified="2018-01-31" version="1">MPATKTAPPAKKAGSSPLLSLWKAYNETTSTRLKTIDSFLVFLMLSGIVQFLYCILITNFPFNAFLAGFASCVGQFVLTASLRAQVNPANRNEFKEVSPERAFADFALGSIVLHFFVYNFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSG2</accession>
    <name>A0A2G8SSG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSG2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSG2"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="27354" checksum="207D1D5FCD16CABD" modified="2018-01-31" version="1">MATADGGAYSYSLTVFSPSGKLVQIEHALAAVSSGTTSLGIKASNGIVIATEKKSSSILIDDSMIDKVSVICPNIGIVYSGMSPDFRVLVAKARKSAQSYWKLYGEYPSTRVLTQEIANIMQQATQSGGVRPYGVSLLVAGWDITRGPSLYQVDPSGSFWAWKASAIGKNMVNAKTFLEKRYNDDISLEDAIHTALLTLKEGFEGHMTEKTIEIGVVTVPSDADLAAGKIEGTGRAKPTFRKLTEEEVRDYLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSQ3</accession>
    <name>A0A2G8SSQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_00480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSQ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSQ3"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="4">
        <location>
            <begin position="174"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Pachytene checkpoint protein 2 C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL36790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="404" mass="44118" checksum="065658284B20B81C" modified="2018-01-31" version="1">MQTTDFCMGSPASPASEQPPTVWPVHIEVRVAPNATSRFDTIRNAVHSYLTTSLSDIYLPSEIEGWEDVPLLASSIERIAASECPCPTSSLPIEQTALQIHVYQPTDADAFEELTSGSGRGEDDQIMAATACELPSSSWEGLWESLIYSDDIKSKLLDYIYATVVFSDADVDYEVESLTAARAGAMAGTEPSDALRVVNALLTQLDKLKHKKNCLVMSTSNLATAIDSAFVDRADIVQYVDLPPREAIYEILRGCLVELVKKGIVSQVDVPGLAQAQLYERTADFSNLSLTAAQPIIDDTASPSAGTMELDPKERSRLLSICLLQLAQKCRNQEMSGRSLRRLPVLAHARYIRTLPAVSPRPASRPNGASKQPFTSGRGTAVETWLDAMERVVQAQATERTRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSS1</accession>
    <name>A0A2G8SSS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSS1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSS1"/>
    <dbReference type="OrthoDB" id="434771at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="961"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="820"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="971"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1057" mass="115396" checksum="B8DFC46DD3CD55BE" modified="2018-01-31" version="1">MTTESNPSPDSTDNPPASSKSLPPPGMTIAHPPKKKRVDDQGPLPPDLGTKPIQLQRRRVWRACESCRRKKIKCDGVEPTCSQCASSKSQCTWLQTKDRAALSRHYVQELEARLLHMEGLFQQVAPILEQVSQATGLDLTAIASAASNLQATSAPAQTAVGSMPDIMQSFLPRIREGRVTGSRSDSRSTSGHGSDDEPTVKMEDEVSNALGQLALDEHGHLHWIGNSSTMSLIQRLKEATTSPLHRVSPMEEDPLAPGPSVNKLYFPASVYFGKVRALPKAEEVEYPERDLADKLVDAYFARFHFLMPVLDQPDFMHRYRLLMDNLTDPHFIRTNAPFVALVCSVFAVASRFVDDPRLTTPDNLDEAGMGMVYHERALILHYISAASMQVEHVQCFVLMSSFLCSVNCLPQAWLLVGQAVRAAQDIGLHRSPRRLLITPIEKETRRKIWWGVYTLDRMLALALGRPLAIEDTDCDVEIPAELDDEQLPQYFEGAILPQGQITLMRGYIELISLYRIAGRVLREVYALDKCRDNLEMEKRAELQRSVETLDRRLTKWCEDLPTVFKSNPATEKQVSMAAVLCSHYYSILTTLHRNFMPVKGEQPFAPRSTAKAVSTARACVRLAPSIKNVVPPSHHLTFFVQNLFSSAVIMLLYAMHTTEAQAAQVVLEEARSCLTVLESWEGQWPGARKCKELLEDLTAKAYEAIRSASNGLPRGSSDSSSYSAAGTSGQSPSTSIHPEGRSHVTSASISGPVPERLIRGKPRRNRSRDVPLSPRNAHAPSQFRSDSLRARSTSRKRPHDEDLFQDQYGNNALGLPSSYPGRSTLATNMSAHGSPGSANGHPSPPGPPQSTIDNEASPPMMHATVPYSSGPLNLPHSPTVQIPSQRFDDYSFGLASPTTDKWASPVVDGNELKFFPSDIHSQGNPSVFGQGHSRSFSGQLPGLDPTSPYLSNFDGSDFGGGSGMGFGGGSRPAASASGGTGTTPPSAGFVAPGLPFHGLDFIRNYDPSGSAGAGPAGFSDHEWQNWQNSFDAFGVDPETAFTLGGDFTTDGTWGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSU8</accession>
    <name>A0A2G8SSU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSU8"/>
    <dbReference type="OrthoDB" id="2752188at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="15691" checksum="14D17986133152A2" modified="2018-01-31" version="1">MHESVRQPRSVALTTPDGDDDEYDVYYFYPSLNRANELASQFTPFDASLDDNTPSYVSVLSFPSYSFNSDFVFPDPHVSVHDISTLGYSALFRRGLWAQSRCVSRRLNAFITRIKEACCSLKNRFRRHRRRTPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST49</accession>
    <name>A0A2G8ST49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_00631</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST49"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST49"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL36940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="181" mass="20534" checksum="659464F88A088E4B" modified="2018-01-31" version="1">MGLSVSRLLSGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYYQNTQGIIFVVDSNDRERISEAREELQRMLNEDELRDALLLVFANKQDLPNAMNAAEITDKLGLHGLRQRTWFIQAACATSGDGLYEGLEWLSANIKRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST88</accession>
    <name>A0A2G8ST88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST88"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST88"/>
    <dbReference type="OrthoDB" id="3258719at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013614236" description="Transporter" evidence="3">
        <location>
            <begin position="30"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="43208" checksum="7D018E0DFC07B7A6" modified="2018-01-31" version="1">MRCCSLSAARALTLFLLALLSSQSLLVTAQSTGVADSPSPVDVASPTPTSPASTNPSPSSPLSPTTTSAPPQVTTPSTSPSSTPVRTPPSTSSTSSSTSTTHTPSSSPTSTTPAPAALATETSSTSSSSTSSSSSSSSVSSTSSSSVIPTISSSLPGVTLVSQTGTTLVATATTDALATDDSATSYTWSVSSSSAATGAVVASSSKSFSFFDNKGAVAGTFTAAGAVVVGIIIAAIVVSKRRAARLQDEEDMTYFEKYEGPNSTNASAANDGSRTPTDPETSFVGQGGMREMDVNDEPLATHAAPDAYPDRAMHFGLPTMEEYSQPAAMGLDFSSAVDYPPGTSYDPTQYAGYEGYNSTQHAGYEGYNPAQYAGYENAYAQPQQPYYAASYSTQSMPAHPYANPTNSPRVAGAPPVQQLCGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUM0</accession>
    <name>A0A2G8SUM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUM0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUM0"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="195"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL37471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="437" mass="48098" checksum="978D3C3100827C80" modified="2018-01-31" version="1">MAATDSISIFAEGTFEEQILELVNYLARALPEDGRPAYIQPFQESLATPEGQKILEEDEDRRRKVFTSVLAEVKGLGDGSEKEIEGFFNLLFSHFLALYPLDEPATRSQLATLLKTISASSDQTSARYRILSNLFNAIPRRSGLRLPVYRTLLTLASANDDLDALGLSQSEIEKWLSEWEVTPEEKSGFINLIVDAYKKSQKYVVSYQYQLAYIRSVPPTSPEAQTAAIDAIATALRLPNYFDFDSLFRLDAVVAAKDHELFSLLKIFLNDGLAQYKEWVAGHSDAFQKYDFNNVQLERKIRLVTLTTLAFQNIGRDVPYSAIASALQVEPSQVESWVIDVIRAGLVSGKLSQTAQTLHVTRASARAFEREQWELLEKRLQAWKSGLGSVLETVSASRKKSGVNAAAGASATDAANGATAAPIGVETPPVPAQAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV46</accession>
    <name>A0A2G8SV46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV46"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="212"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="37162" checksum="A0A6E9DB40ACE1E5" modified="2018-01-31" version="1">MTLSNSRIPIPTNKRRRSPDEGPDGPHKALKSSVDGPGKQALRIVTDIVLAQAESPTLDELLSSTDSDNSLFDESPPQLDTPEISGLHTTLGPQIVGEVTPVVPAKRTAPSIPGLYFDPTLLLPDDVTEDLMMACIRTFFQEGTGNQVMLFERAPATDSDSTFPAPPSSTKLPSFLSDLLSTLDTLLRPCVPPEVHDLLFSPSPATYDGPPRARQAIINLYWPGEGIAPHVDLLDRYGDGIMGVSLGSGCAMQFANVASDQPQSSSVPDECALYLPQGSVVVMTGEARYGWMHGIEKRFDDWMEVSPDSLESVLLERDMRLSIAFRWLLPGADVVGFASGEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVV7</accession>
    <name>A0A2G8SVV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVV7"/>
    <dbReference type="SMR" id="A0A2G8SVV7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SVV7"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="287" mass="32544" checksum="35B3CEF433AF4B73" modified="2018-01-31" version="1">MTDSKVIYVPDTMSHWPWPRKLNPFYEEVEAESIAWLASFHPLTPESQNAHNRAHIGRLAALVYTDAPRERLRIGSDLLHALYVYDEYTDRESSAGVREISAIVLDALRNTDKPRPEGELVIGEIIRDVWARGRAITTPEAEKHFIEAMEVYLEGVAHQAEDRDNHVLRTVDTYMEARRMDSGVRPCLSPCEFHLSIPDEAFYHPVVKELRDASIDLVVLDNDMASYNREQAVGNANWNIITIVMHQYKLDLYQIGLVPGHGVGRTVPQGGEGPLSERTYPDTLVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMI6</accession>
    <name>A0A2G8RMI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ebp2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMI6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMI6"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49880" checksum="CA80FB32DDA0BB51" modified="2018-01-31" version="1">MPSKIKDKKASTAAAKLKTKIKPVVPPTKLQERAASSSDESEEDVEGLEDEKELAPGSEEDDEWQDVSDDEGDSDSDEADVDEDGMERLMKALGEDGLDEFAQEQLRALEEGNGDEEDEDEDAEDEGEEEEVGAVSGEEEADEGEGSENDEEEEEEEEEEEEANEASSSKDVPIPVDELSDEEMLDEDAMPRQKVEIDNKIAMERIRATIALDPSLPWTETLTVTYPETIDVDVEDDLNRELAFYKQALHSAQTARSLAQKANFPFTRPADYFAEMVKSDSHMERIRQRLLDESAGMKRAEEKRKEREGKKFGKQVQLEKIKERQQNKKAVEERLKGLKRKRKGALDGGADGEDFDVAVEDAIADRPSKRAKGANGKSKLPRVARDKKFGFGGAGRRSKQNTKDSTDSFVQRGGPGGKGKGGGQGGKGGKGGKGAPPKRPGKNRRMAQRSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMS2</accession>
    <name>A0A2G8RMS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMS2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMS2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013802466" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="291" mass="31172" checksum="0841985FA61826CF" modified="2018-01-31" version="1">MLASRLLVLCAYCAAQALGVIFESPPSEILDKNYDIIIIGAGAGGAVMANRLSEDPGTRVLLIEAGGSDFMNLNISAPGLSSTLSRSRFDWNFTTTAQAGLNNRSVPYPRGFVLGGSTAINLMIYNRGTIDDFNRFADVSGDEGWSWARLLPFIFKVDKMTAPTDGHNTTGQFNPALHSTHGIVDISVPGMSLAIDTRGLAASAELSQQFPFNLDYNSGDTIGLSWTQSTIHHGRRVTSATSYLAEAFNRTNLDILVNTRVTRIVPVGNVDGAPDMRGVQFAQTANGGRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN17</accession>
    <name>A0A2G8RN17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_15595</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN17"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN17"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL22899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="190" mass="22255" checksum="A7EE49225AC58954" modified="2018-01-31" version="1">MTANAQQVGGHQYHSKAGTERRKLAELVQRNEKRQGASNEEIAEELQRKKTTLDTAKRELRSLMSLNRALKKLVESRLARWHEFRRHNALRCKVYFGYHLSNCGYFGKVLFDYVNGRLHLKEKDPWSLSGRKKSFSTICLLLSLWESIDCPIRCLDVFDVFVDAVNRRILNRHRKPYILVTPQDMSNIHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN50</accession>
    <name>A0A2G8RN50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN50"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN50"/>
    <dbReference type="OrthoDB" id="3263231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="533" mass="51463" checksum="5601B165DE3738FA" modified="2018-01-31" version="1">MASTRDTTQSTSSSSSSTPTSSSSQSSSDSSSPSSPSGTPTTTPPTSSPPSSSPPTSPTSTPPSTTPSSIPPTSDSSSSSTSPTSTGSSSSSVPASITLIPSTTTTSTGTEVSTIVGTDANGSQFTSVVTTTIVTAIPTVGSSTDHNSSSSSSSHTGAIVGGVVGGVAGLAILAALLYFVLKRSHHKDDFDGNFDPDRVVGLSGNGHGTLPDVDLGGDVTPYSYTPGGGQAQGGGPGGGGGGGGGGGGGNTSMPVPQHAGGSAPGNIPNMSQYHASAYPAGAGGYGAGPGAGASGYATGPGAGASGYATGGPGAGASGYAPGPGAGAGGYGAGPGAGTTMANASTGGTSTPSHYSLPSQAATSYYGGPSSASDHGYPEYAAYAGQYPGPRSSSSPTNASFAPQQQQQQQLQQQPLGVSMPGRDFRHPSPGPSLGPSQTSYNGQTQTPTDPSVSGSSSTGGNGNMGVIPSSKEREAMAMAARRVANPNPDGSTSTGQGTGPVMQHTDGGRLDATPEDEEPSEVPPRYDTIPHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN82</accession>
    <name>A0A2G8RN82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN82"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN82"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="223" mass="24863" checksum="E040EBCC763C46A2" modified="2018-01-31" version="1">MSISERLYIQWFPDEASEPTSTLVLTARNRQFVDLRLFKPEDPSGPFTLLEWGLAGRSVGTPSHGIWIHDIDSRTENPHEEQDEGDMSPQPGHPDVVLERGRMRHPESGEIREYEEAWKDLPVLSVDGRRVSVVLETRPDSDAAGVRGMVVRVGQFCQGILRMGSVVVVERWAWTEDGGWGLSARIGDGAHLPCDVTWDGGLAAGDECSRIGISWIAKEVYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNA5</accession>
    <name>A0A2G8RNA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_15680</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNA5"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL22983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="300" mass="32702" checksum="AC65E9C3F18E5809" modified="2018-01-31" version="1">MTAITQNLPWFIKDLGVSIVGQDCYTSIVENLDFTDHECLKYSLSKGLGLGIVVGGSIMKVPQLLLVVSARSARGLSLTAYVLETLAYAITTAYAYRNSFPFSTYGENLFLTIQNVVISALIVHYNPPNVLSNRSALQRAILSTQIAIAFAIPLVVFPMSTIALFQIATLPLSLFSKLPQIRQNYRAQSTGQLSAFAVISQVGGCLARLFTTAQEVGDPIVAAGFALALVLNVVLGFQMWLYWGKDEKDELEMGPIGISEKARTHWTPPPQKVEVVVPPASPGGRASPRPSTRRWSRKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQA4</accession>
    <name>A0A2G8RQA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_14830</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQA4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQA4"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF143">
        <property type="entry name" value="CSC1_OSCA1-LIKE 7TM REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013802468" description="Transporter" evidence="10">
        <location>
            <begin position="28"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="13">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="14">
        <location>
            <begin position="93"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="11">
        <location>
            <begin position="347"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="12">
        <location>
            <begin position="784"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="692"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="822"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="768"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL23518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="94679" checksum="3D974FF3C071EC92" modified="2018-01-31" version="1">MVRMLIPIWLLSWVVLLPITSINTTVAGHMGLDRFIFGNVAPDKQDRFAAHIILTWFFTTWIWWNIRLEMKHFVTVRQQWLIDPKNAASAQASTVLITGVPRRYLTESALTQLFSHLPGGVAKVWLNRDLKEMPDLFDRRQAAAMKLESAETSLINTAVKLHKKKVKKEAKRGDKRRSVDTSRPLTSNSPTTGDAERDVSLAEKLVPRNKRPTHRLPIATWMPFSLPLIGKKVDSIDWARQELAETNEELREARRTLARDVAASSAADVQSPFTSHKTPKPDASLTQTYPPLQSAFVLFHQQIAAHMAAQTLTHHMPYRMAAKSVNVSPSDVIWSNLNMNPYEARIRTAISWAITIGLIIVWAIPVAFIGIVSNVHSLCATYSWLAWLCRLPPVIVGIISGILPPALLAILMMLLPIILRLLARLEGMPQRTMIELSLMTRYFIFQVVNSFLVVTLSSGIIAALPGLVNNPGSIPTLLAQNLPKASTFFLTYIVLQGLTGTASGFLQAVPLVLYYVKLFLLGSTPRSIYGIKYTLRSVSWGTLFPSVTLLVVITLAYSIISPIINGLAVGTFFLFYQLWKYLFLWQLDGGAQAGGSETGGLFFPKAIQHIFVGLYIQQICLAALFFLAQNERKEPSAVPEGALTVVLLGLTAFFQMIITNSYGPLTEFLPLTLADMTHKSKDDQEAIAHEIEDGDDASEGLTSDVEKQQRDLAESEVRKRTASSIAEDEPELGLVADERSTGKAVDANADEDGEPSSPVLSRKGTGKKSQDLEAKRESIMRGVDEEGGPKDFYHPASVEPQPTIWIPRDELGLGEAEARACREEGLAASTRDARMDGEGQVDISGPPPDKAEEERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQT6</accession>
    <name>A0A2G8RQT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_13618</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQT6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQT6"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="142"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="402"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL23867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="468" mass="52992" checksum="2D5D6EDAD4B1A895" modified="2018-01-31" version="1">MASRNMEHSSYPAFRSASLPSHTALALSTTPEPGLFRRDSDCMLSDGPITPPLSPGRSEEGEAAIIVDSEPRYSGPGSQLQTSLSNPHLRAVEAARRGSHSHQQDGMDVDTRPVTSSPRPPQRHLEDEQSHLEKGTLKLTDFEVKGTLGTGTFARVLLVRLRASSGQTTSNCFALKVLRKTEIVRLRQVEHVNAERYILSRILHPFIVDLYATFQDSLNVYMLMSYVPGGELFTHLRRAKRFTADVTRFYLATIILALKYLHSFNIIYRDLKPENLLLDSRGYIRLTDFGFAKIVDDRTWTLCGTPEYLAPEIIQSDGHGKAADWWACGILCYEMIVGYPPFFDETAYGIYEKILKGKIHWPREVDPLSKDIIKAFLHPDRSKRLGNLIGGSQDVLDHPWFRGVDWDALERREIRAPIIPHVASVDDTRNFSHLPLPPAEEIPGLIREERPPSIQQRFDSVAYQFLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRS3</accession>
    <name>A0A2G8RRS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRS3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRS3"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="704" mass="77232" checksum="4F02DA7DA397C90F" modified="2018-01-31" version="1">MPKVTLLQGAEHGAHFLRNYYPDVDISGELIRESITEDENFSRDSGRNGVYAGSTVDVTSFQVARKDHAYLAFPMGERCCELNMSPLVANSKTKIELKPVSTPVHTFDTPIQQILASPHTNDVGKGKMGPVLGVRTMGPVSFMQVKIERTSHTIELSPLITVQRSDVGDRLAVDMSMYPSHTAVGYVANEAGDIYRCLASESKAVIEPIHIANASSMLLCRIAAHGTREKVVASFDATATVLDLRAGKKPYELFSVTKPGVRLTSVEPPSEDHTLRLVSTDEIIWLDERFTRKPLLAVRHSRDFDLTLRTRTHILTNGIFMEQKEKSLVAQSNSVNDVLERMPRFWQDPGAPVEHSLTTFDIALRMGNEPPEASRNDWATGSSLDCAAGYRSLEKGQIPRERLVRGAPWHLDASPSLRRHVPEFDAEPKKTIENLARYNLADDPRRPADSYRMETEARSQLALDLALAADIFSMNRPRGEAPTTLEDDMLSISLSTQAMTLGDMEPPPVHFGFLRPIRKAVQSNGAKDVDSEIGYGDKGTSKLNTPRGVRLLLQEWDLGSNSHEYVYCDPYDESIPIPAAASKRPARVPTTEEPPGPVKGPTQITTQRPPPVASSIPHAPPVIAASQPTLPTRRPLVAARSEGDLVLPLPTPPINGSQPTDVWAAPPSSQDVPFASTQVLPGPHGGRAPLAAKKKKRDKRVSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSL9</accession>
    <name>A0A2G8RSL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSL9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="179" mass="19020" checksum="0913CB27853548FA" modified="2018-01-31" version="1">MAMPVGEPAIPIDEQVHGPTPGQSTSGIAGVDVFSGSELEAELVSAEQARVQQRQPGTDTPSGPQFERLFPNMEWNMPYTPSPLEGYPEGTSISSGAGSTPVRKERIPYAPGNDLGVSTAWGMEGMPAILMYAPERPLLSGAAGSTDSAAAPEHLMLCVVEDAFERAWVAPQGYWRSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSS7</accession>
    <name>A0A2G8RSS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSS7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSS7"/>
    <dbReference type="OrthoDB" id="2751552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="351"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="660"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116828" checksum="A07F8693BDCC524C" modified="2018-01-31" version="1">MSDDNDSSPPRTDTGTETSPPPSPSQPSAAHGHPASDVDSSTTNTVPTAPAPTTQPFDAQKLDKKQSFIRHTPSAYNTFAYQPSVGKDLATLLVDESGMAPRFHLLSAELFLDTIKVDPPTEDDFKKFKKPDIAGKKKEHELYSELAAVVQSVLDAAECDVLRFLDTANHKAQDGNSGRKETFNDGGIYKNSPLAREATEFTDAHRERSKISPDDMARRLLGLRSWNWIDILFELKISEDLSAFYFKTKPRGYKKLYEALAAQSALGKAAAPSSECEEGAEDVLGHTAGDGDEADVGPEEGEGGVGGREDEEDDSEQDNIAPTHDDPSNPDSATADQPAEVDHEDQATNAHPGMTTCQVTVPPFIKQSEKGKITLGQFVEYMLNVRKNQHRVFSYSVYICSDMARLFCFDHAGAFVSQPFQWDKLDSLLHQFIWKIAKLAKAGRFAELGHDETASLASDEEKAKFLALKDDMSLLQHVRDGFKKATADKWPIYKLEVTPGELSEDEWFSDMSFPPPKGFGTSTTPDQPQPSPSQGASPPKPSSSSDPLPSSSNDDPPQSDARHFLVGRPHFAADGLVGRCTRGYLAYDITDTDEKNWRACFLKDSWRPVVPGRTRPEHVVYQRLRYFGAESGIGTLICGGDVGGHWAQQTRVQDYLPEENRPVPRVHYRLVIEEIGIRLEDFDSFPELSAIFVDAIQAHHRAWELAHVLHRDISVGNIMILPPKNNSSERRRGILIDWDLSRLECELGTGPIKLDRTGTWQFRSALSLQYPWKPYMRSDDIESFIHVYLYLVFRYHVTDVDSLRDVVTTLFEGASLVHSVKIGGNMKRTLFVAPRFPYQLPFNTELQSLLDTIIYESSQSYMRIDFNEMQRRYGFGLAAAPPARRPLTAPRATAFVFDRDNMPRRRLMKMRGPAAFAGDKDPCVMEGFLSEAAELVDLFIDHASAGLEYSDKAEDQFLLRKHEDVYRGPIDAGNSRIGSLSTSGTMWSPKPSSNSFALNLGPRPGSNPGPLMAGTSLDSRKRGRIVSGAPVKGSTATNEQGTSATMHPSKRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSX6</accession>
    <name>A0A2G8RSX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSX6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="383" mass="43273" checksum="AC711344909E420F" modified="2018-01-31" version="1">MFADEMDILSLSRWRCTCRANYQHASSSLQRTFTNRLQAFVPYPHQLIDIVEQHGGIFGGEVALSFLLRHDPYRPSTLEMYTSHYQFDNLRAAILNDPQIRARIDKWALRPKTQLYALSRLVSSSLEIRMTNGRTVYVHQSYNCSPSAPLTRAPCTALSNFVTGYGFGCSHPTLTLARRALLADRTLQFPESARDRRVLDRLLAHGFELAVSPATWPEYRDRRSVDVEMKDADDDTRDVAVAADNAYDAPRNRDDNTVGEDNDMTPHLETTQSPEECLRYTWLQCPSQGRFFGDGGSFVGYFDPLDRGEERCMKANVAPYGSMAVWRVPSTFDCDAGCGDVDEVLETGVTSVPVLFFKDPFGELKGLECDRMIASARRRALSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT11</accession>
    <name>A0A2G8RT11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_12517</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT11"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT11"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="166"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL24633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="43569" checksum="AE2D7AC7E31B9040" modified="2018-01-31" version="1">MDQRRNDALKGYREKMRQHENSSQNLKNLRFSLKDLEKDFEKTEDDIKAVQSVGQIIGEVMKQLDDERFIVKASSGPRYVVSYRPTLPVAKLKMGTRVSLDMTTLTIMRILPREVDPLVYKMSLEDPGGASFAGIGGLGEQVRELREVIELPLLNPELFLRVGITPPKGVLLYGPPGTGKTLLARAVAATLNTNFLKVVSSAIVDKYIGESARVVREMFGYAREHEPCVIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDSLGRTKLIMATNRPDTLDPALLRPGRLDRKIEIPLPNEQARLEILKIHSQPVNKHGDIDYEAIVKLSDGFNGADLRNVVTEAGMFAIRDDREYVIQEDLTKAARKVGEAKKHETKLEYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTH7</accession>
    <name>A0A2G8RTH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTH7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTH7"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="462" mass="50749" checksum="E6F8A5620090E8E2" modified="2018-01-31" version="1">MFDCCRVPGPGLDWSVSHAKQGENGRSGHVVVFHRGRVWKLEPWQDGKLLSLDELQRQIQHIYDNTTKEYPGVGVLTASNRDIWAKDFQTLAADPQNAKILSTIHSAAFALCLDTESAPSFISHSRLLWHGAIVPHADGVRPQLGLRNRWMDKPLQFVVSADGKAGLVGEHSVMDGTPTATMCDRVLDLIASPTFAAESNSPLYANHRGSLPIPLDWSVGAATHAAMDSASDAALALINSQALNVVRTPYGKAAVKAFGVSPDGWSQMIIQLAYARLLKAKGWRRNGGTYEAASVRKFLKGRTEAIRVVSEQSDRWVASMNDPQADTKKRVSLLKDAVKTHGAYARAAGNGRGVDRHLLGLKMLVKEGEQMPAMFTDPVVKRSAYWVLSTSAIYTKNFGPYGWGEVVPDGFGVAYVAGFDDFLQFTVTSRTEMPNDEFCEELQRAAKDMYDLFADQVRKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU06</accession>
    <name>A0A2G8RU06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU06"/>
    <dbReference type="OrthoDB" id="2960209at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="229" mass="25882" checksum="21523854E397AE52" modified="2018-01-31" version="1">MYHHWHHAHRCGRATSRLFWFFVGAGTATWWHCHKEFHAWQHAHACGRDRIPQHAYPAPGAAPPPPSPTPATAADAQGPTPGTVDNRDRWGWGHGWGHGWGNWGKENGNGPNGNGNWDRWGWGNRGPNGNAKPEGAWGPGTPSEKAPEKDIMEQATDTIADLSEATLNNLLVTVESLKAKLAEHRAQRDQQERELQALRDAREAKFKQFEEWQRQQEQEQKKESPRRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU83</accession>
    <name>A0A2G8RU83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU83"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="12406" checksum="C135017519B3A3B3" modified="2018-01-31" version="1">MVEIRLYTYTVTVTTYLEDIETPPSFTFTADYRANECIFQLIRTNYSGWVDSQVHAKLMQAFPDVYDSYLSGEPFFPFWEYPDLAEVANKARAKWGHPALHNWSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU93</accession>
    <name>A0A2G8RU93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU93"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU93"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="63335" checksum="5A5E946B36129441" modified="2018-01-31" version="1">MSSLAGALDAPTYDTSPSPKSEDDMDAVQSHLDNQPSPTHDVKEEMDDLFGEDEDVNMIEHESVRCLLLLRYPSQDPASSNLPEPLLPSLQSPQNMKVASPLPNADTESNWNTPRTMTPSPLLNTGSKQMFPFPTFPSLEARTPTSPLPSPNPIQYWVIRMPNFIKLDSKPFHPETYIGPEQEEEDPHHAESLREKSMSIKLKVENTVRWRWSKDEFGQDRKQSNSRIVRWSDGSLSLQLGKELFDISQSIDTSGSVSRQALGSNGALLSQSQSSLSQSQSQGAISGVGHAQGLTYLVAQHKRAEILQCEAVITGYMSLRPTGMQSETHRMLVRAVGQKHSRVARLRMVPEPKMDPEREKLELAKAVARKPRKSRGGPAGEDDGFGGTRRRRQSYTRKRPDDMWSDDEEDDDGGFGKGGSEDEYGEDTSGRKGKRKHLVDETSRKGPGEYQTDDFLVADSDEDDEFGSGESSRRKRKRSTREEEEAGEDDLERLEAKISQNEAEQRKRRQRDASDGDLVAEDLGGDAAGEDIMDVESEDEDDFGVRRGRGASGGRKRRAVGVEEEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUP5</accession>
    <name>A0A2G8RUP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_13108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUP5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUP5"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="327"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL25219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="625" mass="68558" checksum="6187B77C7DA70760" modified="2018-01-31" version="1">MRSDDRTLRQLAQRVLLGPNKASTPSVAARSHNNSSWSISAPLHTENEKLTLKESYDAEVRFAYDVQLHRTSTVTRRGPRSCFSLVLLSAVGLSVFYLFAWSPHFGPFPKTIGLAQNEACSQTTGITPQRTDALLAELEATYLTDDFKSKAYESLGGAVRIPTVAYDDLAPPGSDERWEIFAQLHAYLEKRFPLVHANLQKTHVNKYALVYHWQGSDGTLKPALLTAHQDVVPVEPSTVDQWHHPPFSGHFDGSTVVEELLRAGFKPTRTFVLAYGIDEERGGISGATAIRDYLLATYGEYAFSILVDEGGGYEVKDDVIMSNPGVAEKGKFDMRFEISSPGGHSSIPPQHTSIGMLAALIKQIEANPHDAQLNRSGVYYSLLQCRAAHDTSLSPHLRSLISHSRSSDKALHALERHLAKTDRLFSALAGTTQAADVIRGGVKTNALPERAEVIVNHRIDIHSSVDALQKHVVRVVKPVVARFGLELDAFSKPEFAVKQDGEAAGVLRIADAFGTALEPAPVTPTGDSGPFQFLSGTIIGVLGASNRTGYDKKVFIAPGMSTGNTDTKHYWKLTKHIFRYGHTNHADTFNGAHTVNEALRGEGFIETIRFFTWVILNADESPLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUX3</accession>
    <name>A0A2G8RUX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUX3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="76" mass="8042" checksum="469E16031A97C629" modified="2018-01-31" version="1">MDTNGTTVAGDSPHPLISTSVDQLDIYIRDCCVKCGFRKTAHKLQLEAAILATATPADQHQAAVQVSIFVAGLLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUZ2</accession>
    <name>A0A2G8RUZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_13212</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUZ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUZ2"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="362"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL25323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="593" mass="67252" checksum="C0B4A5BE6B1FFBA6" modified="2018-01-31" version="1">MDFFRTRRVYRLLPVAVLTTCLLWAFMHFSVPDHNLYPFGSDPDFPFLGGPPHYPHAYDGHPPPPPFRPPPPPGHHPKTKWSARAHAVREAFQHAYGGYLEYAGSGDELKPVSNESVNNFNGWRLTMVDSLDTMLIMGLHDEFDHSIPILANMTFALGEGEFAPFFETVIRYLGGLLSAYALSGESILLARADDLGTMLLPAFNTTHGLPMYAVNTVTGETRSGWTGSEILWAEALSCQVEYKYLAHLTGRKEYFDAVERIMKLMYDAELEDDMFPTKWSVRTGKPSNDQFSVGAFADSAHEYLLKQYLLTAQSESKVLDLYTRDVASILRNLLYVTPNRGLLYVTDVSRGTPSHKFEHLSCFLAGMLALGAHTLPLAPRDRELQQWAAHGLAYTCWITYADSEAGLGPDEMEMTTPPKGEGEAMKWLDAVAEWEQEGRPGGAPPGTRNVPVARGPDMERDYRATKTGYLLRPETVESFYYMWRTTGDETWRERGWAVFQAIEKEAKTSSGYASLWSVLESPARHKDEMPSFFTAETLKYLYLLFTDEDLIPLSHWVFNTEAHPLPVFHWAEWEVERYDITTRDRPAKHTEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVT0</accession>
    <name>A0A2G8RVT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVT0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="115" mass="12010" checksum="BC3122750D34CE19" modified="2018-01-31" version="1">MRTRIQTCGHPQLDSQPTKQTLAPPWGASSSSTRPNQPYTRSCPTTAAAPTPGTSSNRATATRGAATAGSSPRSRTSTTRSAPACMCLPTRPSRSTASGTSGSSRRPARRSVMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVU9</accession>
    <name>A0A2G8RVU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_11382</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVU9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVU9"/>
    <dbReference type="OrthoDB" id="2756770at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="15">
        <location>
            <begin position="12"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL25633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="14016" checksum="A34B14308728F1BD" modified="2018-01-31" version="1">MPSQSHPIDYRRASKPFELIHVDLKSFPVPSYHKYQHEILLYDDYSSYAWSISLRTKDNALQSTRQWFSYVETQYGAKVIKWKSDSGGELKSHAFTNMLKDKGIEIIPSAPHIHQQNGCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWL1</accession>
    <name>A0A2G8RWL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWL1"/>
    <dbReference type="OrthoDB" id="10491470at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="239" mass="25108" checksum="815176B337A98D79" modified="2018-01-31" version="1">MPATAPAAFSRIGRRMSLSPAMSVTLYIIVTSASCTNELTSPAAIVLTRSFGNPSGSARKTPAASADPPDPPRETSPWMACADAREARRAPARAETVVMRSLRDEKAGPCVPLAAARGPGVARTLGCWTSMAGWVLGVRPTSTSLTRTRWASRSWARTYRSSSSLVSHVPRSATQGVSSAGGGCSAVGSIVYVESLYANVYKLLEFVYYKLACGVLVRGACTGCGATGFWAFICTMEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXE7</accession>
    <name>A0A2G8RXE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXE7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="164" mass="17802" checksum="D1DE032A43D51B00" modified="2018-01-31" version="1">MDDAAPYSTYNTQRLDSAQLQMSDQAQDDHDYLTHLVVEGVGQSEDHGWSAVEAANWREGSEVAQAMQLDLEVGLASMNLNGTPTGTRTQPATAATVVESSPIVDTNISAGAVLDACTALKNELDAALNAYRQSREVMLWHAANVCRVNMEYIHALRVMNHVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY11</accession>
    <name>A0A2G8RY11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY11"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY11"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="199" mass="21904" checksum="F85C34B531335CA9" modified="2018-01-31" version="1">MSPVAENISSEFEFSSLTAALLTALKFLLISIVFSSFLVPTAIVLFVFSTPLLRRRTSFILNVCAIGFGLTQGSIAAYVTIREMILRPPNPALISVITALYIVGPICVQTILFLRVLAVYPPHELSLRFRFVMYGPAIALKTARVANACYLLYTIQSSTRGPKTILSEAATVWSSPFAKLDFFLQLLDDVYVHPLGEPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYE6</accession>
    <name>A0A2G8RYE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYE6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYE6"/>
    <dbReference type="OrthoDB" id="2755325at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="53229" checksum="4E977E06B0CEC220" modified="2018-01-31" version="1">MDLDRWARFMWYARFVRTIRIIGTKLESKHRELVYALVEHNGDASVFPSLQELQWAPSSRHDSSHFPLFTPQLYTAAFTIPGPTKEDPCRLDQDSESHTFLARLQETSPRLRFLSVDASWQRLGEHHILAVCSFSALINLRLVSTISTSSFSELAAMPHLKCLEVGHVDVWCDGQASPPSPCPARIFAPRLLFLTIFGESNLLATLFTALRAPVLRAATVTAIYNDSNPPRTGTGLGYVRCLKALASFPLEETKISLLEPISPTRMHLAALLNPLLRLPGVTYLALSCPKLRLVADDDDFAAIARAWPRLRTFRLTRAHWDAFHAPGSGDDVPTPEALRVFCDLCPDLRDLVLPYLDLDARVPQLGSTMQAGSPHGLKHLVFGAKAEATNNDEQEARARELAEGRGPGLLERDKVEEWARYILDLFPKLNTGRSLADCVFVPAASGWIEVLRRVQALRSSRMSMSSEETSDGVIAKLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ39</accession>
    <name>A0A2G8RZ39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000038">
        <property type="protein sequence ID" value="PIL26765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ39"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="99" mass="10403" checksum="D5280D2336CCB51B" modified="2018-01-31" version="1">MSRSLALHAARLAVPTRALNSTSTSTEYSTAAHGPKASALKDLKAAGVVDVQAWPLADVKRDLTLAEFVGLGVEVSVAITELDVRFMGLPLDGEGLEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZL0</accession>
    <name>A0A2G8RZL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZL0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZL0"/>
    <dbReference type="OrthoDB" id="3203574at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="194" mass="19173" checksum="F09EFFC248A69127" modified="2018-01-31" version="1">MNFDVSGGLGLPSFGSQVSLGSQGSGLQSADLNSPEVFKQNIQIAQAHVARVQGLARSALAGIEHAYHHGASPVQTAEDIAAAKQALLALVEHLRQSGVGALPMAALDPPGPGPDLGARTDEQLVAEAGRAVQVLYERQKRIQDGAGVVAGLLGQGLGSGSGSGSGGQGAGMGEQLGGQGLNLGGASVRRAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZS6</accession>
    <name>A0A2G8RZS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZS6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZS6"/>
    <dbReference type="OrthoDB" id="2741288at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="368" mass="41684" checksum="407857C813FE64D6" modified="2018-01-31" version="1">MHDGGLDTTAKQVWDYLKDTYGKPGIPVVYQDFRAAMGISIPSDSNPIPAMDKLRAHFQTLETNQFTVAEHIKGMILLSKLPSAMDPIIQVYTSGLTATQTTPAVQLVTFDEVRNRVIMYWEERQGRHQQRPRDSANKISAVKRKPQDPTFRQQQQRPQGQQQHQQRPYGQQHQQQRPQGQQQQGHRGRCGGRGRSQQHQGAHQHAHIAHVADTFPVITKGEMDTLPQSRDPRALLHKPVCTETGVNHQYPALRRVFTLAKELGVEPTTERIRKLEMLVVADNRSKDPILTPTTELHSTRSSPESSATYSEDSCTTSSNVSRSPTPFVGSSVRIVEVDSGEDTDGEEHAAKRRRRTLKERIRPHLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S053</accession>
    <name>A0A2G8S053_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10287</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S053"/>
    <dbReference type="STRING" id="1077348.A0A2G8S053"/>
    <dbReference type="OrthoDB" id="3534988at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1214" mass="134848" checksum="5EBCCDEC0227DC7E" modified="2018-01-31" version="1">MSSIIQKEDVGCTDRIPKYTRPYTSDARRTRNMLTSGSGGTFFLLVLAELASATNIERHGIVSRYNPVRTASSNSTPMQVGNGHFAFGADVTGLQTFLPFAIMSDWGWKNDSLPDGTTEADLEAYRGETWDGVTYLFGGPEPLQDWLTANPGRANLGRVGLLFVDEGGGVADVAEGDLEGTSQTLDLWTGTMTSSFRWQGEGVAIRTVAAQSSDAVGVTIESTLVERGRLGVFLDFPWNDGRTFLGFQVPFVGFWNETSKHTTSLTTGPGLGLNIGAAIAHTMVNNTFFTVVGGGDSFSIERVSADEHRYAIFPNASISSFSLTIAYAPSMVKTIPTVDDIKMESESVWEDYWVKNGFIDLITGSSDVRADELQRRIILSRYLMRVNEAGDTPPQESGLVNNGWYGKFHMEMFFWHSAHWALWNTWDLLDRSSGTYARFLSTSVQRAQSQEGYTTGARWPKMTDPSGRSSPGEINELLIWQQPHPLVFAEYEYRAARSDPRATLERWREVVRATADWMAAYAKRNESTGFHDLGPPMYVVSEDTAPNVTHNPAFELAYWRFGLDHAMTWMERLGEEVPEAWTEVRDNLAPLPIEDGLYAVYEGIPSDFWDSPTYTSDHPALVGLYGWLPQTANLSVDVAKATAEKVWASWNISDCWGWDFPMLAMSAARNGEAEKAIEWLLHPLFKFDDVGMPVSTRVPTPYFPGAGALLYAVAMMAEGWDGSGGAAPGFPKEGWQDLTLLQVKIFVQCNHHMKVPLFSLLGYAVLASRAAQLPFGGQNSFSAYDDGLFTPLGDLSALSSTEFTTLSHPAFSRHKVRVKQSHFCDGSVRAYTGYIDIEARHLFFYFFESRRDPDTDDVVFWTNGGPGASSTMGLFMELGPCRVTNLTETEPNPYGWNDQANIFFVDQPVGVGFSYAEYGETITIYLKSTTKDAGDDIAAFMSIFFEHFTKFKGRALHLAGESYGGRYIPVFASAIYDNNPRLIEAGLTPINLSSIMIGNGCTDFGTMYPSYYLAQCEDPTFPAIQGISDCVRMKQLVPRCEQRFKESCVDKFDSIDCQAAANFCQSSLGGPFNDLNHYDRARPCKGLNMTECYPIVQHIGDFLGKKDIQTRLGVDPSVRGQTFNYSSRAVNQAFHANLDMFSFPAQFYIAALLERGIRTLIYVGATDYICNWMGNEAMTMGLEWTKKDEFRREPLHVWTIEGNKIAGLTRSGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0D4</accession>
    <name>A0A2G8S0D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0D4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0D4"/>
    <dbReference type="OrthoDB" id="2753872at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="274" mass="30759" checksum="C08BAD1515C0E908" modified="2018-01-31" version="1">MSPGSISQPDGYLSHLPPPDSEDSDSSEKSNSDTDDDSPPVRNLTLTPVSADKEVLGLPSDFNPEERKTYNIELLATYETKLHIGQAFDTLEKICEAVKHLSAFIEKKKEAHAVADHVRSNDITKFSIAYCQKLAQSYNRNFDRLLTLQGVLSTLGSSHPVSRLQRIDLANDLKVANLKKALFEDVMDCIDVSDTSQQLIDVDSRANKTVGHVDITYADRLPKQASGRMLYTMWFDRAQWFRVWQEKCHYNEAVNILCAEFRATNLGFAAMGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0Y6</accession>
    <name>A0A2G8S0Y6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase Ty1/copia-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0Y6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0Y6"/>
    <dbReference type="OrthoDB" id="2731005at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase Ty1/copia-type" evidence="1">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="140" mass="16127" checksum="D612612CF484623C" modified="2018-01-31" version="1">MLAGIEDVYSDPSFDYLSYNKALEVSFESVVEQASKVNQEHFGEPWSMSEVMALEPEERNKWLKVAQDQLQSLVENGTFKLVLLPPGRKAIGSWWVFWVRRNADGSIECYKGRLIAKGFSQRPGFEYNETFAHMPKWTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1H2</accession>
    <name>A0A2G8S1H2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1H2"/>
    <dbReference type="OrthoDB" id="2667096at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24078" checksum="9EC3250232AF4496" modified="2018-01-31" version="1">MPSTADTDPQQATPKKVLTAVHNLPKRTRSQTLLGQPARPRASGKENVPPGEKPTSKTEPAAPRRPTYPRRRPAPLLLGRTPTSVLGLSMGSHASPAVDQDVFSHPHPLPVETESQQLHTPQPQAPKSANKWAAKDGKIVIKVWVPSTDDIWKLRVPEDVRLESFRTRVAAKVGFEVSFSALVCGTLRPIADDDVFREWVAGRVVNGRNSLLTAHRLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1K2</accession>
    <name>A0A2G8S1K2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1K2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1K2"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="324" mass="34029" checksum="C2C063D0FB0C5071" modified="2018-01-31" version="1">MSLAFLHAHDGAEPHTDAVWAVNWTTADTVLSVSADGVIKQWDSISGQVSRSRPPHTLGIVSLSVDPTGKLALYNTLEGLTTLWGLEDGEVKGSFESYARGAGSEATEPSWSVSLNPRGGTYASTGGSGNVTIHSAEPSSFGERRTTLTSGRNKFGMHCKYSPDGSRVAMSSEAGQIFVFDVASNSIQVAYSSHAMAVRNFAWSADSTLLLSTSEDKRLILHDVRVSSSGKPGSGAVATLSGHSSWVLSTDISPDSRLAVSGSADKTTKVWDIAARAAVSTVQEQGEVWSVSWRPKPPAHGTAGAYVTGGEDGAVRWWRSAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2C0</accession>
    <name>A0A2G8S2C0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2C0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2C0"/>
    <dbReference type="OrthoDB" id="5579860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="242" mass="27769" checksum="F2A186BCDA23B378" modified="2018-01-31" version="1">MEQPLSRRDDMESLAYTIFRIYAGMLPWSHLESTQSIEISESKQVWSKSGAFYKGDCAYPLASLIEYAQHLGFDEDPDYDRWRQGFWSVDNEPAAPLPASDPLYDPENATECVPRNMEFIPKDPSVTEYNIDSPTHQNVNKIIYEPGSNHGFMPASEWGDAITLLQQDVMRDERGFIQNVVKCISEVPTTTVAHLAPRCPKEVMRKWDDPLPFKPVRTYVLKQMKANEDRMDSATAENSRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2G1</accession>
    <name>A0A2G8S2G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09969</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2G1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2G1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="243"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="431" mass="45955" checksum="20ADED0DD63D572B" modified="2018-01-31" version="1">MPGATKRLADVLTSSSKSPAPDDPVLKESVDTVLVEEVASEECPEGGLRAWLVVLGVVCGMCATVGLLTAWGTFQAYYQEVELPHESSSNTVSNTKEWSPWQVSLTRELSLPVFVASAVFVACVFLTAQCTQYWHFVLCQGFGMGIASGVFFNMGNMVMAHWFKRRLGLAIACSFGGAGVGGCIFPIIVRALLHRMSFQWTMRILGFMALGLLLVSNLTIARRLPGTQDLGPLINIVHFKKPAYSIYVASLVINNLALFVVFTYLTVSAVGEGVNADVSFYLLAIANAVSILGRVISGVLADRFGPLNLLIPATLLTAVVTFAWPFATNVASFVVISIFLGISTGATLALIVQPFARMGPVSEVGLRIGMGLTVVSIGVITGLPMSGAIHDGTGSFKDVGYVGGCTMLLSAALMVVSRRCLLRIEGADWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S340</accession>
    <name>A0A2G8S340_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S340"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="131" mass="14097" checksum="86275705A4A4F10C" modified="2018-01-31" version="1">MPSMCRVSGGAFALNVTVFRFCNADPRNAAPSTRACASPSLVSSRILNTSRAACSVARDSIWQRRNGARGGVRAHALDVVGVHVPRVPSLHRVGEREGLGRALAHVEKLELDDVRRVQSRVSQGEAGIRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3V2</accession>
    <name>A0A2G8S3V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3V2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3V2"/>
    <dbReference type="OrthoDB" id="10672204at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="490" mass="55298" checksum="490EED8F7608A0CA" modified="2018-01-31" version="1">MVTDQLFWPDFNHLIDHHVERPDKLRPCPHRPQLPSVGAEDAGIPSDYRPLDAAYDEDLPDPGCYPLNQDKVDAWNEDDTAARGSIRLRVDDSIGTAIDSKTTAKQVWDYLKDTYGKPGIPVVYQDFRAAMGISIPSDPNPIPAMDKLHAHFQTLETNQFTVAEHIKGMSLLSKLPSAMDPIIQVYTAGLTATQTTPAVQLVTFDEEQRQGRHQQKPRDSANKISAVKRKPQDPTFRQQQQRPQGQQQHQQRPYGQHHQQQRPQGQQQQGHHGRRGGRGRSQQHQGAHQHTHIAHVADTFPVITKGEMDTLPQSRDPRALLHKPIRAETGANHQYPALRRAFTLAKELGVEPTTERIRKLEMLVGADNRSKDPVLTPTTELHSTRSSPESSTTYSEDSRTTSPNLSRSPTPFVGSSVRIVEVDSGKDTDGEEHAAKRHRRTLKKRIRLHLRERIGAVVEDEDMEETVSLGLSSENEQDDDIEEFFDRQCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S480</accession>
    <name>A0A2G8S480_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S480"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="262" mass="29328" checksum="88A3919DEAA0176C" modified="2018-01-31" version="1">MRSVFIIRYGLLLLSDVVLYGAATKWVVDDQTLTAFPSLYFFFTITFAPSSPPFTSILSSKAPESSPKTENQLSYHLYYMRSRAVVPIVTSGNWSSTFVLILILFPFFTVTQANDFTLQPTIPTECSTLTVQWTTTNVKSYSVVIVDNDQSPLFSTTVPTPTIEWAVSVPPVHLTVTVFIPVHTHGSVEFSSYKTTDFSIISGPNTCLSSVTSHNSTILRRILANITTIIDTIHVTVIFNVNHIFIPIRTLSLDIYHLNDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Z1</accession>
    <name>A0A2G8S4Z1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Z1"/>
    <dbReference type="OrthoDB" id="2757940at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="464" mass="52932" checksum="E4E1F02184582C20" modified="2018-01-31" version="1">MKFTTAQLENSLVGGHRRPPVLQVTFIRVDTISLSSSLPLPSLHPYLPWRSNRAGRRRKQEKETIYNSAFKDKDFIIVRKADFQQGISTLLFYAWKHRNSESHLYALYNYIQSLQCHTLLHTTEPSRVITPWPQPLFGTLEPPKGENNYPPRNNALPSNYYPDHARIMIFGSKEQGPSYSLQARISTALDSSEVKVLNIKTAWNLPESIRDAEKTVESHIAQACDSSLAGLAHNPFWTSLYAFLLVGPYFSLFAWKARPEEEQLLPLPPIPKVPHPGGKETKEELEELIAKREEVIRHRMERIRNTPVPEVIHYNEPVFNLTTQPYQKWYDKATLSATYLHALSLPTSAEEELARQPSWFGARDSNRFGESNRRVNIGQDIGHKFVQKMVIDDRIQNELASMNLVKDQPDPTLAGPRPPDSNDSQQSRFSETEPQIFDPDAGPHPMKTRASTQDVDDTDADLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S521</accession>
    <name>A0A2G8S521_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S521"/>
    <dbReference type="STRING" id="1077348.A0A2G8S521"/>
    <dbReference type="OrthoDB" id="5327923at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="60306" checksum="3F960218476E46BA" modified="2018-01-31" version="1">MTAAELNPAYIPNEPASLSHPTPLQLEESSVSPTPPTDHAHLIEEGLSMTVANLTLDDTGSSEAREDALEVTSAAEHDVANSRSLPSVRKEPERVSIPDGSSAATLDALIDLPHLPRPFDHAVPLPAGEEVPPPAADEDKATMASPPPERPLTPPPIGVDVFSLSGVPPLQTFIPDSLFPDDLFVHDPDHIIERCREKLESPSDLPLRYVRIFPNSKGRHEPLPDYFLPLVPDLKPTNQYFMPPPPASLNRSPADEVRVAHLYLKAHNRLSQGHHSSVFAAPLRLRLDPGSQEESTVRIAAKTAPGSCGTHKMLHLEAGVYDAFPRYLMDDQYITGSRSSVTVRWVKPAVVPKFYGYYAAVGADGKPIMPMHLGCHSDMTCPVSWPTRILLVEECGRPILPSAFTPDQRFDCLQLVERLHAAGFAQNSMHPRNVLVQPGPLRAPPAARSYATPSFRIIDFGRGMALSHLPPSIHWMFAKICEGEEWKAARQILGFCEGWDHVRVVAASMVETLLCHMYVALMSMHWSKLERRWVLQAEPLSYGTGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5C8</accession>
    <name>A0A2G8S5C8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09036</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5C8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5C8"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055217">
        <property type="entry name" value="TPR_EMC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22890">
        <property type="entry name" value="TPR_EMC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EMC2 TPR-like" evidence="5">
        <location>
            <begin position="84"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL28989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="304" mass="33472" checksum="48CBCF1DEE2CE2CE" modified="2018-01-31" version="1">MEYTYSLQKLAAYQPRKTKKSKETFDAGLALLNRGGYSGKGEEVWDGIEKLALAAIDEGNLEVADRCIKLLIDKFPGSPRVDCLEGIRMEATADPELVLVFYDQLLDADSSNAAIWRRKASVLRRAGKIERAVEELSAMLDTFYTEPDGWVELADMYASCQQYTYALQSLSHALLLSPQNPSYFLQYAETAYLAEDIPLALKTFLHVVDMTDDDDGDLAPSDSIPTGITLRAWFGAKLCTRKLISEPRSASSSASHTAAPSTTNLSHLGELATERLRTAYLNVKNESPPTVEADFIAAVSTLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S698</accession>
    <name>A0A2G8S698_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S698"/>
    <dbReference type="STRING" id="1077348.A0A2G8S698"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013985564" description="Hydrophobin" evidence="6">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="10594" checksum="95795AA3706B4458" modified="2018-01-31" version="1">MISRVAAVAALFAFPLLALAGGDGNCNTGDIQCCNSFEDSNSAAGLALLGTLGISVQNVVGQIGLQCNPVTVIGGQVTSQCSQRPVCCQNNNVGGLISVGCVPVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S731</accession>
    <name>A0A2G8S731_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S731"/>
    <dbReference type="STRING" id="1077348.A0A2G8S731"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="48"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="203"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="346" mass="38012" checksum="95DB2401A2AFE05B" modified="2018-01-31" version="1">MYAQVFGRRNISSASRGLRGYGTMFGDHCPLVVTSAQLHNLKNDSSVQERDLVVLDASWHMPNSPRKADEEYRARHIPSSRFLDIDRVASPHPLNLAHMMPHPHAFAKACSELGIAPSTHVVIYDSQGVFSSPRALYMFRTFGHHRSSILDGGLPGWLSHGGTTQHEQQKFMHAKYATPTLDGKAVKDYKHMVKNAKLDPAENAEAYYVLDARSKGRFLGSDPEPRPGLSSGHIPYSISLPFTAFLETHNIPDDVASSIEGNLSLTYTRLRSTQGIIIALEEALGPQRAKEVLDGKRQVVASCGSGMTAGVIWLGLKMLGLDSVGIYDESWTGYAMRPASEIVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S755</accession>
    <name>A0A2G8S755_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S755"/>
    <dbReference type="STRING" id="1077348.A0A2G8S755"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="206" mass="23311" checksum="FB109C05320B540A" modified="2018-01-31" version="1">MSTLEAILSNPAYHDYLAILKGARNGFVYGVKVRFPHALIMAILFGRGDWSTRLRTIYRATRQHALNLAKFVSLYKTLLVVQKKINGGKERSADTFIAGLIGGYIVFGERNAVNEQIVLYVCSRVVSSFLARAKSPYSNSPTAPGRPLPPDSRQFSIFAAICWGAVMWLFKERGETIQPGMFSSMTYLYRDSEHWNNLKTLLWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7R8</accession>
    <name>A0A2G8S7R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_08026</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7R8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7R8"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="507"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="650"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="684"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="741"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL29819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="778" mass="86166" checksum="B267838C59EC44C1" modified="2018-01-31" version="1">MAATPPTGFAIPRAPSPSGSRTNNTNHPTGPRHSINSSFSFGPQPLLNSLADASANATSSSAAAYSYSYLDPSRSILQTSPLRTSPRKGRRTPKKIGAGGGTGGGRHPLANDTTDVFQDQDDADDEGDEEDGDGPGWGIVGRMRLWRHDALMQHLYDSAAFWGDKIVSWTNDPNDAFWLAQTYFLKHEYSRAERLLTRPFPTTPPKVGPLTQMNGGPSQPPFAPAAANAKGKGREMPPPPSPIGLGAGGLLAPGVQRLPMGPGEMIDVAIQYEEGVSRLVDMSVACRYLAAQCQMRQGKWSDALEILGESNPFRDDEEGAQVPNVDGGIKIEASMCNLRGLLMLKLNRGDQAKQCFMEALALDVKCYEAFEQLVSGEMMTPDEEWEFVAHLAYREQTPADADFVRLAYQSRLRKYKHTEEHALIRKRLVDEYGLGDNPDVLFSFADALYTQLRWADCFAVTSRILSLVSVHKNTLPLHIACMCHLSHLNPKLFLLAHELVEREPENAISWYAVGIWYMCIHKYQEARTYFSKTSLMDPRFAPAWVAFAHAFSFEGEHEHAVTAYSTCARLYTGSHMPLMFVGMEQIILSNQHQAEEALLAAQHMCDADPLLFNERGVMAFTKEDYETAAKLFESAIDLAQVVQSSQKAWIPTFLNLGTALRRLGRLDEAKAAYQRVLEIDYRNVTAISFMGVTQHLLGNVEAAIVRYHEALSIDPINGYVLELLEMALEASADMGPFGWKGPPGGEENWEKQMREHRDKGKQVAKAMSPGEDFEDTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8U2</accession>
    <name>A0A2G8S8U2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glycosyltransferase family 24 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_07778</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S8U2"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013775682" description="Glycosyltransferase family 24 protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="1592"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="33"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="322"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="13">
        <location>
            <begin position="463"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="14">
        <location>
            <begin position="760"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="15">
        <location>
            <begin position="1300"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1570"/>
            <end position="1592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL30200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1592" mass="177201" checksum="CCE4664B82916CA8" modified="2018-01-31" version="1">MLGALIPLLAWPILCASAGKPPVNVELRTSWQATPILLESLESVAIEEPSSFFHLLDGVTDPSVFPLSKDKSTPKHAHKHVFDIALAMDHLAAPGAYVAAEMHVALHSASPKLEAFYQYYNDHHAARKRAFGKRGEECESWVDWYGSIVCDAKTLARLVEMETLDPAEGDTKAFTGESNSTCSTAPPAPKLLPFDHVLSDPARLLDLPPKTAVLYGTLDSPNFRELHSYLYAAARAPSPHLTYVFRPIPPPPSASSERTYLSGYGVALDLKKMDYLAVDDRLQSGSGGSHEEDSGTAVQDDEEVDPIVTLLQQYPIDESVDVALPLTEEELHEIDFQAAQLIYDAEDKHKLRTLKHLAQNFPRYAGALARRVAVFPALLAELAENQPRARGGVTMAWLNGVALDERDMTPSALLRLVRRERGVMAGLMGGRLGMSSKEGIEVLTHRAVARAQSEGGGPMDGLFDASDRAEGGGVVGYFNDFEKDERYDRWGRNLKIILRQMYPGQFPTLKLNLFNVVLAVDLSQLSSVDFIATTVQMLISRGLPFRWGVAPIVETEDGSRMARLFYFLMENFGGDETLAFFLNISQRDEPMESLKPTVDWALVRSAFKSLLERKAEDLAEDLGLETDLDKILEGTAGDLEKQRAYALRLGTSLASAPQGHAFFNGKHFDLDDDFLRYLQTESAEHLQHVQLKVYKGELTDEEHADGMATYFYDLPTTAKRRNAYVHPSAKAGAGDLRIFGLPDLIEANGLKSSPGAFVYPAESQQVPLTTYVVADFDSEEGAKFLKEALASVTPDSLSRLSFIHNLASSSTRGKSDALESPSRSIAQLIVSDTLSKVAPERLLEALQPKELEESTGEGKQAPFSLSLDELADAEGRVLTAVEHEQYLNACRLVLRQLELKPGEHAVIVNGRVVGPIKPGEFVAGDFETLAAYEHHRRVQPVVDALLEVHGASAEATREDFAELVSVASSIVSSIQQPDPSEAGLFNAPQRPRLRNYQRLSSTYTGFSIGDNSTAIYHFGLLLDPLSEVAQKYTALFEWLQEMPGVYIEFHINPTRFEELPLKRFYRYNIAPRLTFDDNGNEIHATTQFTQLPVEPIYTLAMDAPQSWLIRPKEALYDLDNIQLSKLSGKDRVSGLKAIFDLDYLVVEGHARESVSSAPPRGLQMQLVTSDSTPIADTLVMANLGYLQFKTKPGVYKLEIRPGRGREIFEMESVGNEGWNSPTVGEAGDEVTVTSFEGVTLYPRLATLPGKEGEDVLLATGAHAEEASVVENLMAKVTSLFGSKHKGETAVVPVGDGQAEINIFTVASGHLYERFASIMILSVLRHTKSSVKFWFIENFLSPDFLEFLPHFASEYGFQYELITYKWPSWLRAQTEKQRIIWAYKILFLDVLFPMDLKKVIFVDADQIVRTDLKELVELDLHGAPYGYTPMGDDNPDTEGFRFWKTGYWKDFLRGLPYHISALYVIDLVRFREIAAGDMLRGHYQQLSADPNSLANLDQDLPNNLQREVPIFSLPEDWLWCETWCSKDRLHRAKTIDLCQNPLTKEPKLDRARQIPEWEVYDGEIAAFARRLQSNQTSGSEDESAANPVKHVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAU9</accession>
    <name>A0A2G8SAU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAU9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAU9"/>
    <dbReference type="OrthoDB" id="2190159at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="401"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="279"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL30728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="517" mass="54959" checksum="A433E8CD9AF1859E" modified="2018-01-31" version="1">MSPSSSSNSRPPSPSPAGAPPLPGPPITEGSPSGQSLPESAAPAPAPPHEVAAAAAAVATGPAGANGNPSPTLRAVHGHLPTTTPSEPEPEPELEDAQALSPDRNHDHGGPEPRPHNAGISEGADLHPLPDKELRRITPPPPLRPSSPTMAKETETGAGAGAGAELKPGGAHTPETDEPESPDVPSVIDISGPVRDEDGHGHGHRRREGDSDDDEEEEGGEIEMDTELTIHVDAGPEEALPRASDATAADADADADRDAKAHTDAGSTLYGSFAAAGERVHEHPLSLDVHPSPRRRRRRKGDVEEGEYDDESEDDDEEDEDEEDDLGLGGGGMGGRESPQRFVLTGGGKVGGMQVQEFGSKQSHGRPRIPHSAYYFGPPPPDSAYGSEPTGQIGVHHPREIVRVERDYSGGELPQFAPTYPLELEGRITPTQFLETINAINELLISAHSLGYAFVDNALAYFTLQISRAVKKTHYEKEMDRLKGLIVGLNVEIYNPVGLHIKWPRDAAFLFLEIEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB53</accession>
    <name>A0A2G8SB53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL30995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB53"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB53"/>
    <dbReference type="OrthoDB" id="1111734at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033194">
        <property type="entry name" value="MFAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15327">
        <property type="entry name" value="MICROFIBRIL-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="2">
        <location>
            <begin position="141"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="412" mass="46618" checksum="2FFC7A8C4F9B32CA" modified="2018-01-31" version="1">MSSRQPAKRLPRPAARYWKGKAPKGADAALSDSDEDEAVDVQEEQDEGDVSISDVGGGDVEDEEMEEDGLEVRPAVGKRVKGAITVALKDVSVSKEGKVVVGGKEESGRTAVELEEEEEEEEEEEAVEEEEEESSQEESSSEEEEPKLQFRPVFVPKRSRATVAEREALTQDSEEAQKRKEAELEERKKASHDLVAESIRRELLEKEKEETMPDIDDTDGLDPAGEFEAWRLRELARIMRDKEAELAREKEREEVERRRALPEEQRLREDMERAEQSRKEKPKGQQKFLQKYWHKGAFHQDAEILKRHDFTEATESTVDVSMLPSVMQVKNFGKRGRTKYTHLLDQDTTMGTGGFGGNAPVKAGGTSMNDGGCFLCGGPHLKKDCPQNAYLPPGQDRPMDDGRDRKRRRFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBK7</accession>
    <name>A0A2G8SBK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBK7"/>
    <dbReference type="OrthoDB" id="2735574at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="50144" checksum="189D09550E4C40EB" modified="2018-01-31" version="1">MTTLRELVVTSGSNASPHDQYNPEALGILLTTLQSPLQELWIADYQQEQISLGFLHDHLFRFAPTLDFLNLVDLSSDIFLFPVTTPFMAMRSLRVSSVRHFSFFRLDILLRLFPKLDDTLFLKGFNLPVDEYLPSREQNQEAQKEYTWPGFYCVTCSVALAFTMALRCPIRSMHVYGPVLEEARYLTEVLRDNCPQQLLLPIKLSGHDHLQILDGLFPPEAGDRLTHLVLFFETSVNRRRRPSGEWDNFSWDQFMDIFVHATKHLRHLTHLRVVLYYYIHTPASESASKSAPDRPNASAPPEPPDSDEAFAHNIAHDADLYPTAIRLLSTFPALEYVLLTTCGMRRFGWPWKCWYSSRVWRVQDVVSDSKDPRRASDPLDEALARGSRSRTCVELSEEAEEGVIDKEELYFDQREEAAFCVICRPWVRGLIDLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBX1</accession>
    <name>A0A2G8SBX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBX1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBX1"/>
    <dbReference type="OrthoDB" id="3270641at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013694841" description="Transporter" evidence="3">
        <location>
            <begin position="26"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="47794" checksum="76A9C4BC320EF381" modified="2018-01-31" version="1">MLAALPLLSPSLVLCLFLPIVPVSATLLNITVDDTDGDASGGSTLSFSPHAMWSEGQDCPGCNVHSGNTSGTVDVSQVFDGTWHDSTYHPGDLDHTVSVSFTGTAVYVYNIIANQIPYTTTLTNLTFWINSDLVGSYVHIPENTTALEYNVLVYSNTSLPNGQHFFTMSAGGPNASLILFDRLVYTQDSTNSLASGSSVSISFPSSTSLLATSAPVSASSKSTPPIGAIVGGVVGGVVGLAILGLVAFLVFRARRQTAARRPPPAAEKIDPFVFGGGAQHPQGRRMSRAPILPDLRFGRSRLMPRGPGSTVTSTDASSSTETRTADGFQGHRPRLPPMSPAETARSREAAEYLSRIQALEAQVRALEVQQQLGGRSDASGSRTQLSHGSSTQTRSRRSRSRGRSGRSGRSANASASAANLRSELASLRSEIAALRGELSQDQLGVLEAAPSYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCI2</accession>
    <name>A0A2G8SCI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCI2"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="345" mass="40353" checksum="51AD89DCF4ED8F38" modified="2018-01-31" version="1">MLRNMCTLNHTHIRPLILTSILICMRNHLTLSLNLRPILTCRQHPICTHNPHRTLIRMRIPTLCPLLTLTRCLHLIHTLNRLQFRTVIHLHPVIRILNRLLRHHILIFIHNHHLSLIQVRTILTSNHIIHRILRHILLHTLHRILLLLLLPRLPVWDLTLILRRPLYDDDDDDEMDWEDGDGPQYSDDDYSSSEDMPYQYDPRAHHRNSNSYSGSRRRAYSGSQGQTGKSVLHGAFSGYSTIDHPDSTIERLKMEMAGLRRQSQDAVNASLRLSDQLTASQEDAARAKSALKVAENMLEEEARRRIQAEKNTEEEMRRRRVAEEALRQYEVQARGQRNPNAYPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCL7</accession>
    <name>A0A2G8SCL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06194</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCL7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCL7"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="137"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="980" mass="109585" checksum="1662EC85C4D3E11B" modified="2018-01-31" version="1">MASFEDYDEFGNYIGADLEEDEEDEMEQQQFASQPAIQPLEGFDEEEPGHNDEMALMEIDEPVHNAVILHEDKKYYPSASEVYGEEVETLVQEEDAQPLSEPIVAPMKVRKWTVEEKGMPETRYDKGFLLNMTAFPEFVRNVAVVGHLHHGKTALLDMLVFETHKLTWDSDHQTRYTDTHLLSRDRDISIKSCPMSLVLANSYGKSHLVHLIDTPGHVNFVDEVASAIRLADGILLVVDVVEGVMCNTEAIIRHALQEGVKVTLVVNKIDRLILELRIKPADAYYKIKHTIEEVNTFISGINPDPDLRLSPENGNVAFASTDMYWCFTLRSFAQMYADTYGSVDVNAFADRLWGDIYYSREDRKFTRKPADPETSRSFVHFILEPLYKLYSQVLSEETEPLKETLASLGIQLKPVMYKMDVRPLLKVVLDQFFGPSVGLVDMIAEHIPSPVEATRSKVESTYLGPLSSELAHTMQECSPEGSVMVQIAKLYHTTDAQNFRALGRVISGTLRKGMDVKVLGEGYSPEDEEDMAKAVVEDIWISGARYFIPAEEVPAGNLVLLGGVDASISKTATIASPDVEDDLHIFRPIKHMTQSVLKIAIEPIAPSELPKMLAGLRSINKSYPLVATKVEESGEHVVIGTGELYLDCVMHDLRRLFSEIEIKVSDPVTKFAETVLETSALKCYADTPNKKNRLTMIAEPLERGIAEDIETGRVNIRMTAKERGKFFEEKYQWDLLASRSIWAFGPDDSGPNILLDDTLPSQVDKKLLGTVKEHIKQGFQWGAREGPLCDEPMRNVKFRVLDASLAQEPIYRGGGHIVPTARRVCYSSFLMATPRLMEPIYYVEVQAPADCISAVYTVLARRRGHVTQDIPKAGSPLYTVKALIPVIDANGFETDLRTATQGQAFCLQVFDHWSIVPGDPTDTSIKLRPLEPASGQALARDLVLKTRRRKGLGDQISVSKYLDDEFILALSASGHADLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCM1</accession>
    <name>A0A2G8SCM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the calreticulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCM1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCM1"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013423373" description="Calnexin" evidence="9">
        <location>
            <begin position="20"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="235"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="508"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL31493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="549" mass="60880" checksum="47CCC18C9705C55A" modified="2018-01-31" version="1">MRSVALSALLAVAVSSVSAADETPKPTFKATSIKAPFLEQFTDDWTERWTPSEATKKTPVGTETFSYVGKWEVEDPTEPSIEGDKGLVAKTKAAHHAISAPFAQPISFSEKPLVVQYEVKYQKGGNCGGGYLKLLENGFQTAGKEFDDKTPWTIMFGPDMTCPGTKIHFIFRHKNPVNGEFEEKHLKLPPKPSFGKSTNLYTLHVFPNNTYDVLFNGESHNLGNLLEDFTPAVIPDKEIDDPEDKKPEDWVDTKRIADPDATKPEDWDEDAPYEIPDEEAVKPEGWLDDEPETIPDPDAEKPEEWDDEEDGDWIAPTVRNPKCDEAPGCGEWKRPFKANPAYKGKWYAPMIDNPAYKGEWAPRKIANPNYFEDNTPVKSLVPIGGVGIELWSMTEDILFDNIYVGHSVEDARKLAEETYFVKKGVEEAAEAAEKEANKKEEEETAELTFAADPAEFIRVKVFKFLDLAKVDPVLAFKTHPETGAGLALAVVTLFGMLGVLLGGAQQKPITKSTKKTDAPTADDKQKTETAPVAPAGGEQKENTTVKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD36</accession>
    <name>A0A2G8SD36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06387</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SD36"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1106"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="597"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="707"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="749"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="958"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1014"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1385" mass="151094" checksum="670D705EB89E32A7" modified="2018-01-31" version="1">MSDDARSIHTRQPPPRRKRILVVSNASPESSADEGPPPEPQKPYGYPRPLPSPSSSLPSAEQLYHDRHYSPGNNSHLPPPLTTNLPHYPSSRSNPSNPALSSPSSTSSPAVESTPPPSTPGLGGPSLHIPDEGTIRQDMITPAASDRNDSTPQASRPRGIFERIRSHVPNQVHERRYSSGGSRPATSPVVSTPESYLSHGFRSSPMEKVIVLVTTDAENLHVVDITGAMTPAFIRERIFTKLQISDEDQAKFAIYRTEIGQFAIGDALTDDELFGLYKDFGDQTGKLKLLVSHTSASVHEPGPYDPPLTSTVNTIPPPVLPQQTLYAPLRPNRDTRIRQGSQSSASEPHHAEVGYEASVSDDLDHGDGDGGLRDARDYGRPPLPVRALPIPSYRPPSPSGYHRSRSPTGLLSPERRHDPYHASIGAFPLPGTSPQASRFVDDHHPLPPLPPEAQAPLLPDPSVEQRERSHTNEGQISTYNTGLRTKEERGREQRERERGKRRETLRKDSGRYKPDQEDSRTRNDAWTIVPGDVPSSEYRKDRPRTPQESRSNARAFPTTPPSAISSYRNAPSESSTRRKPLQVPLNWPVNWKHIYAPPKTDSKPVLSPPGNNLIRHGAKSMTDMRGAYKHPPSLQPGRPPRAPPPQPPLPLITRPSTGGNSTSVLGGPPLPSASSSSDTSTIHPDQIASASDIARSVLSSRQITASYANSPATTGGYLTSPAQQDPFPRPHSALGESSSAPLTQPRYPHSNQPSDSSHAQGTPPRSPVAPPTPVTAQSLPSDSPAAAVGVPGDGFAKRGAIDEDGSTQTVRADDLKWLEGFIDENLAEGTARPRPKQPPPAQQLPTPPSTTEITTLSSASCATFVNRASQNDDDSDSDGGTSFWLVPPKKAEKPAESQQLSNALKTRPPLTPLSIEGSPNSTPNGLPAVSSYDYGRSPPNQQLEFLASPPPSSGLPRTPRRMPAQKKHKDRISKFDNNFDMTWAPRPPPEVMYEKLEEYFPEHDLDKPVIETPSGGTSPTATEAPSNPAPPRFRHKKSIRLVAAEHKRQLDRTSRGDNSTIAPLSRKRHTKMWGGKLEEVTTEQGTGPISSTSDASPGGAKPIFRWVRGELIGKGTYGRVYLALNATTGEMIAVKQVEIPRTASDKDDSRQVTVVEALKLESETLKDLDHPNIVSYLGFEETPTFLSIFLEYVPGGSIASCLRKHGRFDEEVTKSFTGQILAGLEYLHSKNILHRDLKADNILVETSGVCKISDFGISKRTDDINMAAVYTAMQGTVFWMAPEVVNSKAKGYNSKIDIWSVGCVVFEMWTGQRPWLGQEAMAVLIHLYQTKQPPPVPAGIELSSLADDLRLRCFAADPDLRPTAAELRRHPYLELQPGWSFNGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDA2</accession>
    <name>A0A2G8SDA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDA2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDA2"/>
    <dbReference type="OrthoDB" id="2339190at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013715132" evidence="1">
        <location>
            <begin position="34"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="169" mass="18559" checksum="21FA2337D6FE16A2" modified="2018-01-31" version="1">MVAARSSLSTIVFGFPLFFVLALSAAMFPVVDAFYIPQEFNIDAARNETDRSAALARRDVWSPGILSPNANDVWQAGSVVQIRWDTSSPPAQVTNYMGRILLGHEQDPDGNEHLDFEHPLAQGFNLSQGAVNAIVPYVVSSDDYFVVLYGDSGNRSPSFTILQRPLIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF43</accession>
    <name>A0A2G8SF43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF43"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="78" mass="8631" checksum="65BE7224CDAAE36B" modified="2018-01-31" version="1">MYSITLPSLNPYATYLAPGEKASERGRAAVTVPVTLALSLGSRWESEPEEPVAPERIPDLHNDGREDRPCEEDLRPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF51</accession>
    <name>A0A2G8SF51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF51"/>
    <dbReference type="OrthoDB" id="2758757at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="111" mass="12773" checksum="CEF81A93910522E2" modified="2018-01-31" version="1">MPKDTGPSIMLWRNPPRQVSNPYANRPVQQPPVITQSLPPVNYDHLPRPPVSPNNDGTRSDRIGWVLTHPDLQDQVRHRMIGIPYFFVFSGIYRNCTRLGTYLANLRGHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFY1</accession>
    <name>A0A2G8SFY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7928 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFY1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFY1"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="2">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="275" mass="31136" checksum="A833B60D975E3120" modified="2018-01-31" version="1">MDYNAYDALLHHIFKQTQGDVWFKPSEKNIHAGVYLRVDTGVFHVFPYDNTFLEPFEASMRVLNPIIAVKIRSVAIHATLTTVKPDVDAIYVDENTHIQILDSILLLGSVDKERCGAFIRDERVLVVWSYHLDTTILTCRNFEEKLIKLIWDGHADLSSSAPSVEGSSNASSNVNVTEKVKEQHTEADAKEVPIALEAEAVHNKPLKKTWFWGLSYFVANKADVEKITDGPSLRPVRLFAPFYNGLGVVLSIFFIALRSHMSSLLFLHVHHRIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG12</accession>
    <name>A0A2G8SG12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG12"/>
    <dbReference type="STRING" id="1077348.A0A2G8SG12"/>
    <dbReference type="OrthoDB" id="2749397at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27750" checksum="A5652DA978BB82E3" modified="2018-01-31" version="1">MSRGMPSSPEGIQACRDQTMMVEEEEDKPPPPGFLPEWDGTEESLLNALATGQTLRNAPKLFVSATYTYSQQLAEQEYQKKEIRPVEEIVPKQYHEYLRVFSKEASERLPDHGPYDHAIELVPDARMFHSKVYPLLPSEQVELDKFINENLAKGYIQESKSPMSSLFFFVKKKDGSLCPVQDYRRLNDITIKNRYPLPLVSDLMDRLKKAKYFTKLDIHWGNNNVRSKTGDEWKAVFVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG39</accession>
    <name>A0A2G8SG39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG39"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="110" mass="12522" checksum="29C4F5344C7598FF" modified="2018-01-31" version="1">MDDTLPFLFSLSPTIRILTLEFELALRAVIQDREFLSLFLSLISDPSGYPLDPSWRQTMDLVGDTAEVMQYLGKCTRFNMLEELDVIQIQHDIHHSSISTLSRLPPVSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGL7</accession>
    <name>A0A2G8SGL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGL7"/>
    <dbReference type="OrthoDB" id="2733590at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="149" mass="17189" checksum="E51878A7B3F9D300" modified="2018-01-31" version="1">MEPPTDVVWKKFTSSKGKEYEVGYSAQTQPNDLRLVDVQAKNGGSVGLRVRASDSRPFGIAVHWPVGPGQWVDTTSAVRDVTRIYSYTLHKYGGTVWSYMLQFANEKTRYDYYFYDETGDSYQVNTWLIGTHWVRYNSHKPTINYVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGQ4</accession>
    <name>A0A2G8SGQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGQ4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="96" mass="10510" checksum="ECB1FDBE9FB6BE5E" modified="2018-01-31" version="1">MDFGPVMEGKARCQEDCKRSDDSFVGLVVRAHRDTMVKRQRTWQDVSMLSFAIGLTGVTMGGRISILPVGWFSGCEDGRAMALVESGTGTRNVELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGQ6</accession>
    <name>A0A2G8SGQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05064</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGQ6"/>
    <dbReference type="OrthoDB" id="2740733at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140996">
        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="649"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="597"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="777" mass="87234" checksum="B287C1174D4E92C2" modified="2018-01-31" version="1">MPPAKQPDDASAKRRRRESDEAGPIESSSDDAEARASPHAPPPPPRTRSAVRKTATKRAKPTTDDVSSAPDPGELSTENDDAEKTDGVPEPEAASDAVSRSSSTTFTGRRAARLEEKYGDLSTQESLDARAAKWTSHVYKHFRPPVLATNKQGALTSRFVCIKNPSKHVDRTLTDESTGNLHRHIQVCTPLPPTDTKEITEYAQGVNYSYARLQYLLAMWIARRHRPFTIVEDPEFRELLRMLYARVEIPSRVTVSRDVKDIFEDSRARVKAKLQVLGVTCDNASNNAKMLKEMKKLNPEFRGPDARVRCFGHVINLVVKAVLSQFGQKVKSEAIGETDKDLSALDDPEDVEDDDDDDDEVDEAREAADRADIEEDEGEINKRLSLSSQRTSRSSRGSRFRSPTVRDEMSRQAKDAGKKSEVLIRAVRTRWNTVTMVLARALDLRPILFGVCDKAEFNKSQGVRLRRFIIEDEDWPILEQLHELLAVFLEATMAISHSSTPLLHDVIPWIDVMTHHLEDTRDNIEKLPIVRAAAQKGYKILQKYYKHTDETPFYRVAILLHPCYKKRYFARARWPHGWVEASLRLIRAEWENHYRNRGDPANEEDQTGPQRDGEPSHGASKARESAGRAARDMLASLTGADELEEEDALEEYLEAPLRTKQTDPLKYWHNALVNGTANPGLAQMALDILSIPATSMDAERAFSRGRLTVSRLRHSLSDQSVRASTVLGSWARYSDLVPEAEAVELLRSKEKGKRKVAAAASDATVSEPGRDVITLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH35</accession>
    <name>A0A2G8SH35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH35"/>
    <dbReference type="STRING" id="1077348.A0A2G8SH35"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13757" checksum="20351498AC61E8B3" modified="2018-01-31" version="1">MEAQATTTGLNPRVEKGYYSSLEAARKHLPLQLLADAPEELARGLPECFVLQSEKEPAFLDESNEAFMKALERRLGRNVRYEVMKEHNHVSPHLALSTGNREEYAKNVLAWIKAKARGAHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHA5</accession>
    <name>A0A2G8SHA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_04536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHA5"/>
    <dbReference type="OrthoDB" id="9979195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL33087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="550" mass="58922" checksum="4D96885F68D8CEA3" modified="2018-01-31" version="1">MTAEKAPSLLSATLASGSSLVLLQVFSRVVTFVLNQALVRLVSPQVFGTTSIQFELLLSTILFLSREGVRNALLRASSQHTADHDATNPLITNISLLPVALGIPTAIGSALIYLGSSSLTTSSQPHFQMSVLLYVSAAFFELLSEPMYIRTQNELRFHVRVRAEGTAVMLKTITTFLVLVIASEDYALVAFALGQTAYGLTMLVSFLIACRGNLDFIPKQVTVTVKDHAEKKYFDPTLFNLSVAMTGQSLVKHFLTEGDKFLVSRLSPLADQGGYAVAANYGSLVARIVFQPIEETARVFFSKTLTSTPNPDPKSKAPTSQSKESLQTASTVLTTLLLAFTHLLLLLVTFAPPYLPLALSLVLPRKYLATSAPRILAVYVYYVPAMAFNGVLEAFLASAASPSDLRAQARWLLLFSALFVAAAAGLARGLGLGDAGLVWANVGNLALRAAYAWVFASRFFRERGGGRGGDGVLLETRRAVPPAPVLAAFAAAGVAVRASARAHDGVPVDLLAQKAHLAVGVVGVFGCLVTCVLFERRSVMQLVDSLRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHQ3</accession>
    <name>A0A2G8SHQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHQ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHQ3"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF14">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT FE(2+) 2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="439" mass="48156" checksum="02962068670C6EF2" modified="2018-01-31" version="1">MDEFPLLQRLEATLTMSGPPYCSGILEVPPEAFNLYYGRKNAQFIDLQETATSNDPSDLEALANACERAKFGRGDETVLDETYRKAGKMDADDFMTGLDLEATGLREAVQLGLLSDKEETRGMRAELYKLNVYGEGAFFKPHKDTPRGQSMFGSLVVVFPTPHSGGALVLRHNDDQFTFDAAALLSGRGSSGSIAHVAFFSDVEHEVAPVLSGHRLTLTYNLYYETRRNTPAPGRGLEVFQPPHASAPTVKAALAAVLNVSTFYRAVGRLGFGLRHAYPIPKVWTTDMGSPLKSLGAWLKGSDAALFSACAALGMTPRLRLVCKDYEDGCESEIMLDQMLELGPEGIESLELALLACGGVHVCDSYTFTGDARMPWKRVESDDWNGVTVHWVTKASARDGPRSAYVAYGNEASLDWLYTSVCLLVDVEPYVYRSRRMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI29</accession>
    <name>A0A2G8SI29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI29"/>
    <dbReference type="OrthoDB" id="2736021at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="212" mass="23419" checksum="264872065C280DC3" modified="2018-01-31" version="1">MPEPLIAVGECEPAVICPLEIFKSTHLFPSLCFGTTNRDGSEKHYICCFPQHANPELPLPKTPLVFSLYGQIAIEDCFLTVRGCLRPMDEEPVASCWLEARPNIAADILWRGIIPSIEAIVDKYGGVVDPSHLVALGPDGNVRLQVVWQGNIGESGWRLPMFDEFGTQRVPASISEVPFGEAMHATFSLEFVHDRRAGTRTVFASLYGMFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI86</accession>
    <name>A0A2G8SI86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI86"/>
    <dbReference type="OrthoDB" id="2755869at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="278" mass="29539" checksum="D8ECD573B1E8647A" modified="2018-01-31" version="1">MSSTTSASPSSTTTSSDGNSSGGTFFSSGGSTLILAFLAIGLFVGGLLVMFSMRRYVSTNRRRMRAWQTTGERSWGWDAAAIGLPATMLMDMNSSRGRKDFGKKPELWDVRVGATSRTLVGEWEKATPIAARSLYAPPNPSSFARSSNPTTSSSISPSPPPGSNYLRPFQIGLRDTRAQIASLHIPWLRQASNISSPRSSTQRLVDATPRPSGIGAEELTAPRAEVAIAIAFPSQSPCAPGCVPLFALGVTNVRWAGELSTLDGSTDSSPSPPPRYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIK0</accession>
    <name>A0A2G8SIK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIK0"/>
    <dbReference type="OrthoDB" id="2754287at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="568" mass="62554" checksum="5EB518C15FF49526" modified="2018-01-31" version="1">MSNFQDSEETVSRVLELVSHLGGPSCTEDELKWAADIPAGKRLLDWLVGQFPDPTFTDRMAGSNHDPSPAHDVSGPIQTAVSPIALYSEEMEILDALKAEDSRVAAREPRGVSIPAAYELPSQLRARTKVLNAEAVLLERQGNRLKYRLNATKAMAKDLKHSIHALRKQIQDLDGSIQDQQQRLADFSAETDSGMAQHVDLASRALQDVIPASTSDSSNILDAYGADLASLSGSRAAAASVVKELYLTLDERYAFLPTVAQLEHDAAYVDAKLGDLTKDKSLSERLLQAAYVEELEKMAKMLEASPTGPDTIPNMIRTSARVLEPTEVETGRPPPTLKVDVKGELERAGRMDRRVLLKAQERGLDAVINYMRGQLIPRLQRTYDDLHSRGVAEVETEAIVSALIEELEDINDAVENAKRSSPDGIQEGPESLLEVEMIELLKALPCNDGNTPVLLNREDVEREVSVLSARLSTSRAADKKWAYQLRDRVRELFSSNAPLLAMAYANSAVNTSPPFAPSRDQVIVQTNTRAKAEELIDAAGRLQKDTELSSRDKRKLGAFTDKWVQSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIU2</accession>
    <name>A0A2G8SIU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_04313</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIU2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIU2"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="441"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="859" mass="91814" checksum="C8C0E7F6C9141DDE" modified="2018-01-31" version="1">MATTGQPFQPPRLALNVNTEEAPFPDALFDELSTAVKGPVLRPSDSKYPDRARTFNGKLKPSCRVLVSPLDATDVSAVIHFCRTYGLSPSVRAGGYGIAGWAVAGDVVVDMSMIRDIDIEPPVERAEGEGEAVPDWTPLKDMPAVGSKGKGRAQPPPPNLTLRLTAAAPSSPVGDVSTGKRRRDSEDVPDGLRADPTVLSTPAGRGPYDAASHAVASFLRGPPLPPIPGDIPREPPTNRPRLHSPEPSSPLLMDSSNVEHSSGANQDQDVDMPHQHSPPAPRQEARDLGESIGSSLSSAPPSFASNAADASSTSAGEAPDAFRYMSSNPMPLAFGQTVGSDGASLGVSAVSPLAMGRFMQPPPGASPSSGVMAWNPMMGFSSGAPGPGPSQFPFLPNSMAMPPAAPSLSAMGLGPSQMFPAMPGASAAYIPASESGNGPGGHLGTMHYARPVHPHAYVTFGAGMRQKEVDMYTADHPFVGVSPVTGEREEGAVPYHIPMSAHPVGSSIMLLAGFGFISRLYGLSIDNLVEVEMVLADGRIVIVNAENDPDLWWAVRGAGPAFGIATRYKVRAYPIPVVFAGNIIYRFHRATAPSLIKHFRDCIKDAPRELYANVLLTAGPADKDSLVVIQICYVGPKAKGVEYLQAISSWDGERCLLNEVNEKSFLNQQDSVAQVLRGKPGRQWFLRSALITSLTDEIINRTVLAFANTPIGCTWIFELAGGAIGDFEDNCLPKEQREAAWTVAALHQWDMGIDDPRCITSAEAVSFLIFDSSCMGIDVVVHQWMKTTISPMATGGPFPVFLGRHEDPGRTMACYGKNWSRLAELKRRYDPDCFFKNNFWPLDKDGNPIELLTNEPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIU4</accession>
    <name>A0A2G8SIU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIU4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIU4"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="256" mass="28965" checksum="1DAF1B48FE899563" modified="2018-01-31" version="1">MSTAHRPTWDPAQAKDVKGGSRQFSVRDMAAHTKLKFRQPGQTSEAEVSKRDLRAELLAAEAEARDRKRKAEGKPPLAVEAVAGKEGNAIGQDEESNKRRKLLQEALELDKDDDDEDEEENGEKAADDEDEDDDDDEDDDEDDTAELLRELEKIKRERAEEKERQEREQSATDQAAREAEIATANPLLNLAAALGQTPNGINTTQPGSFAVKRRWDDDLIFKNQAMSSRDKDKDPQFVNDLLRTEFHKKFMAKFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ00</accession>
    <name>A0A2G8SJ00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ00"/>
    <dbReference type="OrthoDB" id="2269034at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="310" mass="33989" checksum="EF3FB78D57230726" modified="2018-01-31" version="1">MAAQEVLNLSSMPRSPSKPFVPLLGLRDLHLVMHPDQLSALLRHIETSPDNLTHFSIALDDSKSDPDPQMSSPRAIAPGTSLFSSPLRQTLPALSTFNSLTMAFSCCVLPFMRGGAEARWGSLSTSATILFHRPDYVEGGGSPFTGNLQHSFDNLVNSILEQGPLSEVRTLVVQCSRTTVPTAAQVSHILRCVPRIRTLVLDVDRSDTHKLIEHLVQARNTSSVPAAPDLQLVVFDLRMLEKDRLRGGLPEALKPLAVRKVAFVGLDLEMRNSWPPDGKIVDSFKAQGLEITWGAAQRSDTWKKILAFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJD6</accession>
    <name>A0A2G8SJD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJD6"/>
    <dbReference type="OrthoDB" id="2748701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="385" mass="41593" checksum="91452C86178071CB" modified="2018-01-31" version="1">MDRVPLETLQQIFQFACTDGGYTGGSLALTSRFIREAAQSTRFHSIAVGPETERLTTLVALYQSQCSNATAGRPRTTHLYISTSKPTEDDYDDSEDEEPAPARFVAIRELLHLVTADLQSLVITKDLFAAPRPLFARPLPALRFLTLVRHPDPAALALVPPNSNSNHPDDSASSVAPLFPALTHLHVVAQSAPAPGPASAKHSPFFAGWAAHAPRVTHLRVSAHPRMYALLEELPRALGTPPFRGFRAHTDAGEVGKVGARTYPSLARVVVEPGAPPVRGACGTSRLAYTQRSVQLHWLAAQAREVGVEMCVPAPCHCARTEREWDGAVREGWVRSIGGGDGGEAGGGWFDDEEEDNEDEEDVEKEESKEVGNEGLLPARAPRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJS5</accession>
    <name>A0A2G8SJS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_03740</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJS5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJS5"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL34031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="390" mass="42640" checksum="B2FD9989AA8C0CC2" modified="2018-01-31" version="1">MAAHVKRTTALTRTLTRSLATLNNAPPVGKSPTAIVMLNMGGPSTVSETHDFLKNLFLDGDLIPLPFQSVIAPLIARRRTPQIEKQYEDIGGGSPILKYTKIQGERMAAILDELHPATAPHKSYVAFRYAQPLTDETARQMKADGVKRAVAFTQYPQYSCSTTGSSLNELYRRGKAGEVGDGVEWSVIDRWGTHPGFIEAVAQNIERALAKFPAENRSDVVLLFSAHSLPMSVVNRGDPYVLEVSASVNAVMDRLGHSNPFRLVWQSQVGPSAWMGMQTGEALKGLARLGRKQVILVPIAFTSDHIETLYELDLEYAKEAREHGIDIHRAESLNESPVFIRALADLAASHLKDYSNGMIGPTTLQMGLRCPGCSNATCGAQKGWFARAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKD4</accession>
    <name>A0A2G8SKD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKD4"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17731" checksum="FEE69E6D3CBB3BAC" modified="2018-01-31" version="1">MASCIFIPTGVVPPLPIELIRRIIDLADPSSLYTLCLVNSIFHEVAVVHLYNQPETPKPGTLVRCLQTLSCPPELAGHTRSLVYGRFLGGTSHEHNINYMTYFTTAFGMLIGSAKSNLYNLTSLTVELLGPIGKYLRGAPFRLATLDTTAEWDADFVAFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKN7</accession>
    <name>A0A2G8SKN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKN7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKN7"/>
    <dbReference type="OrthoDB" id="2627610at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="228" mass="25243" checksum="F20A2E775FE9AB80" modified="2018-01-31" version="1">MPNISYDEILEFRDHRNSINAVAFSPDGRRLATGGDDYLLFIFDPLTGEIVHKLEGQAPVTAICWDPHEAGRLFVGYGTGRVLVAQTTSETLSAHYLPRSICDKPVEDLACDAFSGVHRILICAGSRVELWKEVEECKRKLQFWVSYGLRLIESFQVRWVETKLEPPELIVAHASQSSSSEVIARSGHIVNGGHSAVITYLNHGTVTAYPKQMLGHQFSGELPVAHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL71</accession>
    <name>A0A2G8SL71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_03289</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL71"/>
    <dbReference type="STRING" id="1077348.A0A2G8SL71"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL34511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="194" mass="21746" checksum="CCA3851B35322140" modified="2018-01-31" version="1">MSEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVMHFCAGLPIILVGCKKDLRRDPRVIEELRKTNQRPVTPEEGMAVAQKIGARHYLECSAKSGEGVREVFQYATRAALLSRPRGSKKNHCIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLA4</accession>
    <name>A0A2G8SLA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLA4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLA4"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF44">
        <property type="entry name" value="PROTEIN ZNTC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="598"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="618" mass="66743" checksum="EB95FAD381113F11" modified="2018-01-31" version="1">MSGTFIQDAAGTQPQDPVLRVENEQETTQRLLIMLLIFVVSLTAVSFPTVTATFRAIRVPSIVFFIGKHFGTGVILSTAFVHLLQDSFKALQKPIVNERWKIGDFTGLIVLISLLIIFLVEYISTAFVERLQSYPSAPSTPTESVVPSPAESIQMEFDGPLPSRPAILVQSPPGSSAAWIDGLPTPRSDLPLGGASQPLALPTPSPTNEPAQPPLPPSPHPSHSHSHSLPHSRSHSPTLTSEREPLRDERNFDYGATLPRAKHTHAHSHTHAHDDVSDSFFSGGHHRHEPRGAHASHHARVSRWRFLGITFPWYNGSGAAVVVGQETGDADADVEDGHRHAYSGSHAHNDAHKPPSSKGTPPPPPRQPSLHAHHHGHGRSGSRKGASPSLRSHRSHSHGHGHGHGHLDMEQWMSDMDGDNVAPRHVHVHAPDEELGLDGSGDEVTKVGRRRQVIGILVLQLGIMIHSLVIGLTLSISRGSEFTSLVIAIVFHQLFEGLSLGIRIAGLPSSHHEHGMHHFPGHTLKPLLAFTFATTTPLGIGLGLLTLHGHTRGPHLILAQGVMSAISAGMLIYAACVEMLAGDFVMDAHLWRSSVRRQVLALVSLFMGVIAMAAIGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLP6</accession>
    <name>A0A2G8SLP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLP6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLP6"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37735" checksum="FFCC6A84E26C1F25" modified="2018-01-31" version="1">MLLLRQFYRLSQLSSALHDASPTALADLFLPNGWLRDIFVFTWDLRSLEGPEKIKAYLIDRLIDAHIAKIRLNETPELAPRVYNAHLSEELGVEFAFTFECAHGHGRGYAHLAPDAKGVYRAFTLLTELSDLRGHEELSILPLRDELTAVPGADMQKEYADMVRATEANPFKQMNIPTVVIEREARIGDTWRKRYPSLTLHSTRKHHTLLYQPYPTNWPEFTPRDKLADWLEHYASIQDLIVWTSSELKPRPTYDAKDHRWDVTVVRNGVEVKLRPAHLVFATGTLGRPVIPDVPGMEAFQGRVVHSSRFPGGAPFAGQHAVVVGAGNSSIDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLQ2</accession>
    <name>A0A2G8SLQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLQ2"/>
    <dbReference type="OrthoDB" id="2753410at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013755421" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="21213" checksum="552418773BF788D5" modified="2018-01-31" version="1">MYALAVLSIAVLAGQAIATPFANTGPLAALLKRQSTLDPSQIPPQCQSQCTGVVNSLNTCTDLTCLCADAVNKGLYNCLECALSLTPDASLLSQAQSSLTHLNPHPSSEYEQACTQGGVAVTPLTLTLPSGGATATGGSSGTHTTAVGSSVVLGTSVVVGTTAAAGTLPAGTINTVVPVTTAASNSNPNPLSKNGAGLVGVSVASVLGAAGVAVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM15</accession>
    <name>A0A2G8SM15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SM15"/>
    <dbReference type="OrthoDB" id="3267748at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="705"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="460"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="726"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="756"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL34763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1376" mass="152560" checksum="1FE61140DDD2348E" modified="2018-01-31" version="1">MSTPKASKKLPGAWTSDEVATPGADARTSDEAAAPAANSPVPFLEPLEFEGTGTSPSSFHLPAAEPGVLPVHPRLSLAPVTDDDLSLKWGIPDFEELAEAAENRRMTRRVAKLARSGESSSKPAGLVYRGHRGLREKTMRKTKQMDAETCPSDSEPVAPSAPGAPVVEASQSNGEPAAPSAGAPVEGTSHPGGEPAVHNAGAPIEEGATPDAETAAHAASSRSEEDEIEELLGSSQGESDRAPDDGWKVTKAGSSPVLSTQRDLAIAAQYFPSWFDLCEDEDQYGPIPVDWLFSPSGTPVLPDIKVDPSLLRDFWQDVESSDEERDVQRAIEASIVTAVAERERREQAGGLGLHAVIVEVPSDEDEEPEGPAGPDGRYTTEQKGKGVRRTKDQRDFLREFVTGRHSKSEKDKPKSKPTKGKTPAPQGPTHFKREPSQVPEGGWFHASTAAGGRIPPSPPSSSSSSSSSDSDSSDGSSESGYDSSDSSSSSSDDGRGHRGKTPSEKRHREKQKRETKRIRKALAGVKIKPPFSWNGSPDLDLFDQWTYEVDTWRELYGLSDKLAIKLVVQFLTGTAGKFFMKHVATCQSEWTIASLYEALFDYCFPTDYKAQLHLRLEHSVQGKSKVRDFVREIQHLAARFPDVSDFQLAQIFWRGIHGHIRVYLIEKGLHPERTALDKMVKYAARREEAYVEARRDERAFEGQVPGRTWGRFANRTTGPEPYQPNREQRDKRGQRSEQRDRREQRSEQRDSRDQGNRNGQGRQPSGSGQHRRGDHKKGAQSEKLTKEQRDKLRAEGRCFTCGEKGHESRNCTTRKTARAPNVGVNASSVRFANIERLAENARQANGGVRLASIRVATPGDSQVGATSSATGDGIWVRAHTSDCIEYLLTLLVSYFDPEEACAANMEPEDRFTVRTYNYELYDSEFLIIDHLAPPESPDEFVVSRTQMDDPEWGIPDMLQEAWEDYSALPARASPNLEGAPQDRDIWARAHVSDCIEYLRTMLITYFEPEEARTVGMEPEERFCIQTNSEELHDHEFLVYDRLAPVESPAEFVVSRAQLDEPEWSIDDMLQEAWNEYVSLPPRAEWGQGFPSRGVPDKRYPARFWLKAKLMAALQQGYPYLSDLGYSVSVKPHAEGYGMFMTDIEEPLFIGHEEVCSAAFDAQSVLTAVVEDAGLDVLESRMAREARRRQRRMTLMVCAARTGVKPRKGKKPEQPANWIPAVERNAMKTKDFTRVLPKPIVVTVQVNGQPVRALIDTGSMADFLSTTIVDQLGLKKEVLAKPLPVQLAVHGSRSKINCCVTVDFQYQEINCKRRFDVVNLDNYDMILGTPFLFQHKVAIGLNPIRISVGSDKPLDIQGEEIAVITSAAADLLEDELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNQ5</accession>
    <name>A0A2G8SNQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AhpC/TSA antioxidant enzyme-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNQ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNQ5"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1151"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1279" mass="139568" checksum="1BAB5ACE0E5830BB" modified="2018-01-31" version="1">MTPDDTLTTSSVSVRERSESLSPRTFVSELPPPSSSKDAFEESDLHSHSLQRMTVVEGGHTIIESGGLIEREVSQIRSADFPMLLGTSAPDSSVPVLVPPPRPLPVPSESEPEQRFSLDSRRRSGAGLGSRRDSITNRLRRSSFLGRVRKMSDPSPPSRTKKLPLHETSSSYASGGHVVRSAVGSMIVVGSSSSPEVVRVSSLTRETSDTKRAKMAHRKSLSHVSLGVTPLPTVNFGPTASPGFPTENVSMTSTLVGGDPDQDEYDAPTNANLVPFRPLQPPQPEPVAQRPQTVAQALELTPLPPKDAPLPPIRKDTRLPTPPRETWRSSRAPVPPSGTEYDRRRETQHARTHGVVYNEDLAPEAASHATLTRPSTLISTAHASAEMEMDEVVLMRHSRLERSTNYEPEQASPSPPLLSNSLLARPTSTTATISHVAPAAPVPLVSPSPISAHLNAPVLSVAVQPVRSDIVSRRGPSPPSPLRRSSPLPPRRFPESPLPAPPEELEPATPAPLPLSPPRRMDADLPTPLPQPPLPQPPPPPSLPPALPVARAPLDGVERSEKPPAPISAPIRPLSPYESLPRRSEERRASDNRQERATTTYFPVAQARPPSPPPPPSPQPATGPPMTSPNANRSRTKVGQSGTPYNSLRQRRPGQAQGTTQTASHTQLPFRPTSPSPPLPVPTRAQSPQPASAPRPQPALASHHNAPAPAPATIAAPTRAQSPQPLVVTSRAQSPTPRRPQSPPVQVGTPSGQQALMRAAAPLPPPPSSYTSHGNGLLQARSFASQPSSMDHDVDRERSRSNVPAMSTESAMTSPPYAASVESTPLPLPNTPSTTFAHPYRASTTTKQHVRSSRGLSEPETATRPRTVKSGRSHCRDRGMVEETAMATFDEHAGLTKDQLQRAAALTVVSQSGVRVPFGDLFRERKTIVIFIRHFWCAACQDYMYSISRNVDYHALQRAGIDVVIIGNGSPGMIKSYRNIFRTPIPMYTDPTLRLYATLGMTCRSNDPGPDVEKGEYVRHGVIGGLAMVVRNFLRVRMPVWERGGDSLQLGGEFVLGPGSSYAYAHRMTTTRSHAPIREVLRAAGYHRMVSPEASGYGGLSFTHEEEEAWMQDRRRSLARLRAKREKRRQVGMPGEPEVYGPELGYGSDAGSGSVSVNGSWTSSAEKHEFQEQLAKKQGRERERGREQDRSVRSKEKRQRRSLQVANPDVRSDHYDHHEHDHHDHRKHHSGARAHGSRNDTNRDDWQGGKISVEYLNRHGRREDGYETEDGAAYTRRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNR6</accession>
    <name>A0A2G8SNR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_02144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNR6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNR6"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="143" mass="16436" checksum="EDEAD74AFBC362A0" modified="2018-01-31" version="1">MPKNKGKGGKNRRRGKNENDDDKRELVFREDGQEYAQVTKMLGNGRLEAMCFDGEKRLAHIRGKMRKKVWINQGDIILLSLRDFQDDKADVIVKYTADEARSLKAYGELPENAKINETETFGEEDGECTFEFGEDEEVDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNU8</accession>
    <name>A0A2G8SNU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNU8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNU8"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="245" mass="27661" checksum="91CD7FEA09AB1F27" modified="2018-01-31" version="1">MSPAKQITFYTAAYSPYSHRVQLALDEAGAQYKIHEFGKSKGSKPEWYYTINPLGKIPSITYGGPDVPSDQPSAESEKLSESIALLEFIADIYPEANLLPDNPVLRAKARRVISLYENYVHDAFKAAVFLGQPYEGLLQALSKFQSALPPTGFAVEQYSIADCAVAPFLVRMMVFFRRGLGGYTYEEGEKVRQALAGEEYARFRTYIQDVTEHPSFRVGWDEDDQIELWKDHPAFKRSKTTQAHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNV5</accession>
    <name>A0A2G8SNV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="6">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_02184</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SNV5"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="11">
        <location>
            <begin position="743"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="12">
        <location>
            <begin position="938"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="10">
        <location>
            <begin position="1183"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1278"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="474"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1339"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1354"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1387"/>
            <end position="1406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL35457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1430" mass="161385" checksum="A0F4D643F34B0653" modified="2018-01-31" version="1">MGIPKFFRYISERYPLTSQLIQENKIPEFDNLYVDFNGIIHNCSHPNDEDAHFRLTEEQIFTSIFAYVDHLFGKIKPKKLFFMAVDGVAPRAKMNQQRSRRFRTAKEAREVREKAERKGEKLPETKAFDSNCITPGTEFMARLSEQLRYFVNKKISEDANWRDVTVVLSGHDVPGEGEHKIMEYIRLSRAQPDYDPNVRHCLYGLDADLIMLGLLSHDPHFCLLREEVKFGPASKSKGNKSLDAINFYLLHLTLMREYLDLEFHDIEPVLPFDYSLEHVIDDFILLAVFVGNDFLPNLPDLHIHENGLEKLFDVYKKALPSLDGYLNENGVINTKRLQVILDEMAEWEKEVFEKEYADINWYKGKQAKHVKEMELGRKRSKLVLTSSQRKIFDRVKKFVLERRKLSVAQQASHRPLTMVNDFPAADRAFITRLAQDLHLSVAWDEYDEEDRNLVAWRFPGELEEPFPENGNGNTEDDNEEEDWEDEDDEESRAAVDRVLNKYGKAKVMEDDKEGDFDARYELSIKEKMDEWKRGYYKGKLEISYDDPKDMGDLIYRYVEGLQWVMHYYYSGVASWSWFYNYHYAPRISDLKDVDGMSFKFDLGHPFRPFEQLMGVLPEASKELIPVPYRDLMFDPNSPILDFYPTEFEQDLNGKKQDWEAVVKIPFIEEHRLLKAMRSREAQLTEEERRRNAFGTSTKFTYRPGEPTVYPSSLPGFFPTLHRCYCKMEPFDLPTLDGLHLVEGLCDGVFLGADALAGFPSLQTLPHTALLGPHGVNVHGSESRNKSMVIHVDNAHENRKVEDIAQEMIGQRTFIGWPFLQEGKVIAVSDSLFKYEKLSLVQGDPPKVISNPHTPQALGLWKMKAEKIEHFYSKRCGVITGNIDVLLHVRPLKGLKRLDDGSFVKDYEGPEKETEQAVQMAVSEVNSEDARFLEKEAPPLSEEFPDGSKVFFLGEHAYGVAAQVSATDANTLSVILAFFPSEKTENEQFKAVVSNRSQNKYFPSFKVADMLGISSKALSKITASFMVITGDGSKSNLGLSLKFEAKALKVIEYSRKDGRFWEFSEKAVQLIHDYKATYPEVFRVLDRSGDAMVKGTDVFPGVQNPEAKVKEVKTWLNSKGVRDFEPVSLFCDQLGKETVKEIEALADNLTASKQPGGFKKAIVKGIPRQAVLKPSHAVYRLQNQHFALGDRVTMVQDSGGVPLSCKGVVIGMNSKSMDVVWDAPFMSGTTLSDRCSQYRGSTVEFWSCLNLTNPQFQASTNPKAPHVQKPHVPFNPRFGPRPSVQPGPGMQPVAGFRPAATPQGAHNGMGQNGPVQIMANPNRGRGGAIRGGSPAAHKVAAPPTATPPTDTDTANDSTKASSSASGPNGNYVQPPPQRGRGGPFQSNGFQPRGGFRGQRGFAPPFRGRGFGPGGERGGFRGRGGRGHVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP63</accession>
    <name>A0A2G8SP63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP63"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP63"/>
    <dbReference type="OrthoDB" id="424465at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="511" mass="56831" checksum="A2760BADE7007E5D" modified="2018-01-31" version="1">MLIDLPEDILLDVIHYLEVRDVITLRKTCRALHTFGGNDYVWHTLIAAFPLPIDVPFNTRPTALPGDELQRHAIKAIRLDANWRRLKTRVCGMRALLSDKSGQYVDQMQFLPGGKWLWTAQRTLKREASYTRMSLWSLDDVEKARRVWSTEVSGIYRSCTVVQSGEDDFATLVVGVCDQREVIEMHSISLQDSAPNLQYGFCPNYPIYPPPAPVKSKQLQVVPHPRAPHLRPIIHEIATYGTMLIVTIFALDTGGGAGSLQILFVNPETGATKWVDPSFAQAFSFLWVRVWGDYLFLVGQVSEDFVVRVYAMPRPFAGTPSRTGTPPASPSAVPMPDDSDEDDYAYSNLGPVVAQFAGPTPMAVPRHHIPQVSPASTTPTLSAIMFYHSSSPHSAQLLHFAFDFSSETVTLKNMASKDFPISNESSPQLAQVGALGLRAVWLEHNWETQLNRVMKLAYDPATGAVKVGMLLPPDPELPFSPNMCHSLAFDEVTGRLCLGMYDGNVYLLDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPF0</accession>
    <name>A0A2G8SPF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_02350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPF0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPF0"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="176"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="381"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="433"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL35622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="57177" checksum="D474E1A63C1B3053" modified="2018-01-31" version="1">MPLFARYVSRIKVEGTYWIPQLAQLQQTQQDGDGHAMLAFAKVLFAILLAGHALAAPAASSSASASVSVLRHSSSSRSSSATSYSAAASSSSTLASGTSSALPASETVPYASDDPNGVLWSEDSTTDPQAIREGLGATVIGPQNVPIALQNPDLLAPPSTDSGSIQNAKWPLALSHNRLQTGGWARQQNTDVMPIAKSMAGVNMRLQAGAIRELHWHKTAEVSGPMFSRSALFHGDSDGNVLDVAEVANCDGGLPLQGSVQVTAINSDGQNYLGTASAGDLWYFPPGIPHSLQATDDDPDGTEFLLVFDDGAFSEDSTFLLTDWLAHVPKDVLAKNFKANMSAFDHIPAEQLYIFPSAPPPPDSQNQVSDPQGQVPSPFIFKLSQVNATQLDGGSVKVVDSTTFPVSTAIAVAEVTVEPGAMRELHWHPTQDEWAYYLGGTARVTLFGSSSNARTFNFQAGDVGFVPASFGHYVENTGNTTLHFLEIFNTDRFQDISLNQWLALTPPDLVKAHLDLDDATIALLSKTKYTVVGGTTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQL1</accession>
    <name>A0A2G8SQL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQL1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="161" mass="17353" checksum="B752BC951B194A90" modified="2018-01-31" version="1">MSSDPTVTEPVNRCANTDKHKDKDKHEHEHEHEHTPAQSRRLLSARANAYPIVPYVLTLLWLLSAAAAVFYQRAAAAVPPLSRQTHKRVPAAPQLCSASHGPWRPPTSDGANHGYRLLPPRPTNSPQTAGSERGLADVAVRSFHAITPPGAIAPSGPYATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQU3</accession>
    <name>A0A2G8SQU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQU3"/>
    <dbReference type="OrthoDB" id="3363417at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="291" mass="30379" checksum="9938C4A73F1E5848" modified="2018-01-31" version="1">MSLASLPLTIWHLYVDNLVFYNGGSWVHSIASTFRFLAFATIVPFILLTLLDVASYIIARTLGVIDETKASTSGEHVAGLHAHPNNPNRDVRPPAIVVHDSAEDADMTALAAATPLPDDGEHGNLKLSGVDTFSPAPSQPGSPTLQRHEFAQLQTAHWEPDSVTSSASLSMSSLYGRDSIRGRGTRGGGRDGEEEGHYGSEKLRRAAGDGDGDGVDGTGEGALVGGPGEHEHEHEHGAASPRGLSGHVSAGSSSGDESYAILDRDSGSGTEDAGLVLRKRTRQGGTGADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR97</accession>
    <name>A0A2G8SR97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR97"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR97"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="607"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="736"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="780" mass="84995" checksum="2C35F878A0C082BA" modified="2018-01-31" version="1">MRIGLFSSQFNFRSAQAEAFGEEDEQLEEIDFADIGELQAKVDAAATKSNPTGLQAVTKTESASFFEDTTPAPVGTISSADRIQVNALDGALGAAAVDEDEEIIVYVAPHPRTGKSTSQAVSSPIAHLPTPGPKDVEIVPAASSTSTPTTSVCEAPTVKASSSQKPFSLELGTLYPERSSSLRQVAPPSPDAVELPAPPAFDSVSFSFDKATPATKKPARRLHPANTPRALLKRSRQPRRRSLRGSGFGFGSFGPAHEEAMLREVDPRRDERRRGDSDLEWGTADEDEGEDGEDALSADMGGMELDEDINLAAMKSFVHSMSAEGSRHVTMNDVADVARMKEEDEEEDRRGPESASGESGDEEDNENAGDKHAPRNFVEDEEPGPEESDDDDYDDEEIEAAMNAEEGLLIAEPGEVVEGEAGDEDEDDDEDEENKEDDEDEDDSEDKEDEDEVTPTRSFQARLERMRASRRKGKGKGKATEDSSDEAMSIQVIWEDGEEEWLGIDDILARNAHILGTGNRKARKYMFKAIQNGDFADTPFDTTQPAKRRKDKGDDLPPELREQWENDRQKKAENKKKRALERMKLAADPLAAHQGGKKGRKAMLAAARTAEDLPNRIVDFITLEQQIRQFLADIDGGDTMALPACDKQTRKHIHDLAGAFDLKSQSKGKGDARYTTLIKTSKSGLDIREGKVYAIMKKATNGTWDAPRNGNWRGKANLAKHREGEEVGKGAAKIDGSNVGFKMLAAMGWSDGDRIGLSGGLDAPLTAIMKKTKLGLGATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRP4</accession>
    <name>A0A2G8SRP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_00126</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRP4"/>
    <dbReference type="OrthoDB" id="2721240at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013560409" description="chitinase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="47"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL36437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="323" mass="33873" checksum="0BBEF8CB9068BE06" modified="2018-01-31" version="1">MFSFARMITSILAALTLASVSSVVVAAPAPADGDVSSISARAVAPSSRFVIYSDNWVTGALPAASALKGYNVVALSFLTLKGAVDQAKNWESLAGSKKTAKKNEYHKAGIKIIASAFGATDTPTTSGANAVNTANTMAKWVKSNGLDGIDVDYEDLSAMNKGDGKAEKWVSDFTSTLRKTLPKGKYILSHAPLAPWLAPSHQFKAGAYVKINKSVGSLIDWYNVQFYNQGLYGDCTGLLTKSGGAFPGSSLFEIPKHGIPLSKLVIGKPATSADASNGYMSPATLGSCVKKAKAKGWNGGVMVWQYPHANAGWIKSAKGGAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS37</accession>
    <name>A0A2G8SS37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS37"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS37"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="534" mass="57825" checksum="C2F8726E599F68B8" modified="2018-01-31" version="1">MYILPRGRQHPQLVSTAASPTPTSPHAALTRARTTMHLRPTVFTWLLAVLPVATVLGAQIPVVENVIGGTAVEAIIHEAKLNIASVQPAATTPGKLRVTENSGVCETTEGVYQASGYGDLTAHESIFFWFFEARNNPDSAPLSVWLNGGPGSSSMIGLFQENGPCRINNDSSDVSLSPNSWNEVSNMWALIDIRLYIDQPVGVGFSHGTMSVGTSQQAASDFWTFLQIFFADERFSKYQQNDFAIWTESYGGHYGPTFAAYLLEQNAGIANGTVTGTPINLKFLGVGDGLTDPLSQYPGYISYAASNPYHALVSSSTISSANTSWSKSGGCKDLITSCYNTSNTTTCSKAQSFCNANILSPLAGDWDVYYVLTENPDPYPPDLNSYLSDSNLMGKIGAENDWEETNIVVYSNFAETGDWMHNSRPNLETVINAGVRTLVYDGDADYILNYNGVEAMVDALQTEFSDEYAQQEFANYTVKGVATGLFKNAGTFSYVRIFGAGHEVPAYTWGSLSTGEAALQFFSQIMSNSSLSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSM1</accession>
    <name>A0A2G8SSM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSM1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSM1"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="11544" checksum="AE5B44008657C3AE" modified="2018-01-31" version="1">MPNVRVLRDLKARHGVNANEILRRAYLYVARNQTLPPQVRFQAQLQLNTFGRYTRPTTVKNRCTETGKGRGIISEFGLSRYQFRLKALANELPGVRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STF8</accession>
    <name>A0A2G8STF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STF8"/>
    <dbReference type="OrthoDB" id="515064at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="137" mass="14601" checksum="BDA8C63737751D6B" modified="2018-01-31" version="1">MRAEEQQKSAAKRMRPQSTVVEEVKPQIADDEDMGIPTPRSNSKAIKEMSAVPDVEPSEVLDRAISPVSTVTSGSEPPLAHRVKMNGIVHIVIIVVHVIIHVLVIIVFVGDGSHGESGIHSKLDIILNRTGGGGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUF1</accession>
    <name>A0A2G8SUF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">YAF9</name>
        <name evidence="5" type="ORF">GSI_01084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">The coiled-coil domain is required for assembly into the NuA4 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUF1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUF1"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="8"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="260" mass="29661" checksum="BAF27E0B7C86FC36" modified="2018-01-31" version="1">MASNDRVRVRGVTIHRPVIYGNTAWALTQEERDELPHPDHTHRWTVAVRSAASVPDSDTVGGADDLGYFIKRVAFKLHDTYPNPNRNVDKPPFEVSETGWGEFEVTIRIYFVQESGEKAITFYHHLKLHPWTAVGSGEPEIPTLENALKSGPVHSWQYDEIVFNDPFQSFLNILTAHPPTMLPKVKRRPVPFHTANPGSLEASKGGTPEFQQEMEKEEAERIEKALKQIVEDTHKWRNKLIEKENESNKLKKELEAAIQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUJ4</accession>
    <name>A0A2G8SUJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUJ4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="186" mass="20257" checksum="4491D4F3B34E10DD" modified="2018-01-31" version="1">MPRYSGLPERRRSSIGLDEEHRSRYQSVIQVYHRQRAIRPITGIWTYGEQPRSQLIHKWAVSVPPQHQQAPIPACGLLRTTLLHLSHPEASSFGPGGGSRAIACASPDATAPSRFCAFHQLLVRLLDGLDWGKQACIHAWAIYHVVEASGAVGRRSSSGCVPGRPKGRGAKLNTARHDPPAVAGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUM7</accession>
    <name>A0A2G8SUM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUM7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUM7"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF5">
        <property type="entry name" value="CHLOROHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="57"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="480" mass="52871" checksum="0E88DD687106CDF5" modified="2018-01-31" version="1">MTKYLLKGGTIATSVQGSDEPRVFKADVLVEGDTISRIEENISPEAGVEVIDCQDKWITPGFVDTHRHVFMTVLRGTQCDWLLTEYLVKMAWSLQGTVTPEEVAIGTLAGLLEALHNGVTTILDHFHAAHSPEHAEAAFKATIESGARVIWAPARQSPPTRLLPFPEWANDAQAVQWQRAKIKEWGSLAGGKLRPDGRVTLGLAYEIFNWEEGTVPRHQEFLAYARANNVQTITAHVVKSPSILGWRDAGILGPDVVLSHCNALADRPELDDEMWKALKDSGAAIGATPLDELGMAHGNPVAFDALKRGVKCGLGVDCLSINSGDIFTQMRVSLQWARGHDHERIHLNKEKAPFKNKYTCADAFRLGTLAGAEALNLAHLIGSVEVGKRADLLVFDANSVNLGGVEDPIAGVVFHASSEDIEMVFVDGEIVKKDRKLVRDWAPVVKELKQRADDVRKRWPAELLEQRWKQWYDANGAPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV39</accession>
    <name>A0A2G8SV39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV39"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV39"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="239" mass="27265" checksum="DE6FA11F7E4609E7" modified="2018-01-31" version="1">MEDTTASGKPIVDREKTAPFLIRTFVKIGNYHRLGQFEDGPLPLSDEQHIYTWRDATLREVLTTLRSSAPASTEYRHPLARYSFRAVFADAASRGRFSQKDLGTVYSRDILGEPGSLDAPAPRLFDDTEADGPGPGSGRGAGGHWRGNSTIDRPAPRGGRGRGGDFGRDRDRERERDRDVRDRDRERDRDRERDRDRERDDRRVPPPRRDSPPRRGDGGWGRRAQSRSRSPPKRRGRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVG0</accession>
    <name>A0A2G8SVG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVG0"/>
    <dbReference type="OrthoDB" id="2751721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="13840" checksum="1737B5B18E567C87" modified="2018-01-31" version="1">MPVFSKISSKTASATSCLSSVAPKAKAKVGPRLPRGATVVTGIKLSVTVATKLDLSVPYMQGISEAADEIMKYSDAVKTNRKQCKRLAAVCEELMGALLAATEGVEERDLEIPVSLSLAELEWQMQSPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLD4</accession>
    <name>A0A2G8RLD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_15019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RLD4"/>
    <dbReference type="OrthoDB" id="1689567at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="61"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="333"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="610"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="981"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1158"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1210"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1313"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="993"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1215"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL22331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1343" mass="151233" checksum="DF608D9691E57E27" modified="2018-01-31" version="1">MATIQNRPFSKDYSGLINQSVVAAGIFLVTITAHECMRRSRRGKGPFPPGLGSVESWEFGYLYQGRSWAKRPSPPLPRKWPLEWTKQVLKFPEDRFNELRGVDATLYIRWLRGCFWFAVLQCLTTLVILFPIHVTFSDGTVSSKSMTRASISSLVTTAKGLSLLWVHIVLLVWITLSWFGTLYWICKGAFRYRAQNILAAANRVARQVQAERDAQYDPHPHPQYPFHALPPLDEDHTNRGLRLRTIMVTNVPHSLRTEKELKEYFEYYLSRRVARPAIGITSSTQPGFLNKTFAFLFNRARRLPAQVHLMHPLPGEQSSRRSSPTQEARPEEYEAPAIDRVVIVRKMNELAAMLERREEILRLLETAHIKLARKALASVQAALESRNNSPRRLRTAVRRVSVVAKRVSIAESFDVQAVNQSEEGSEEGEDRTQLLIRTLKPYLPTLDSDLASEGRLSGWRSHFSKTLSDLETARRRAREKAPETSENDKTVWDALLSLPRSTLDTYQPLIHLSSIFRGKTVPAIDYYTAKLLIVTNMITEKRSMPLSDFEPMSTAFVSFVDPADARRACKYLAVHPDNPLQCLVTMAPSYEDLDWTRLMKPMFRVEFVKDWVVELGVWAFTIFWVFPVSFFVGLVNIQNLSTLWPGLLDFLQTHQWEEELLQSFVPTVLVALLSLLIPLLLLLIAKRAHTIATLSTLHDRIMTRYYKFLVVNVLVFFCVGTVALQSFLLSFKSVASSKVVNVIAQSFPVAAPFYVGWFIFTTAMHGGLELALFGVSPLSYYLDLDSQPVLASTDDWLPNHVLVMHVLLVFALLNPLVIPFALVYFSVERTVVKNQLLHVYAKNYEGNGQKLLIRMVRYSLDGLILAQVVFLAYMVVNEKTINVAISAVLIIITALYKMFLTRICRARFERDDILEAQVVCGTGQATEELIDEGAPTTGEGGPADLQATLANNAPGEAFPWRLPFELNFAYASMASRPRQLPRHLPNPFGPPRRSSSTVPLNPSSPTEEVPLRRPTLETCREASNGSENLPHPESNPAVVTKHHPHRPWEDESSLNHTYENPYYTRSIDNLLWLPRDPLDILNLDDTVDLRMSLTTQPGAGRLGAWREEDFIESGFSIPFAASIASLEEDTDTARLSYYRRLDGTEQIQLPPVIASRVSTIDQEDEVEMAPTYRRQSRRPRSNHSGTGGLQRPHTFDIGSSTGYRTLSIGSVSQASGRGPPSGVPSSFVLPSASHRRNRAASMDHELGMRPTRDYPSMGGRSALSVIEGAASRPLPFVHPNSVYPNSGSGVSGSKIISVQEAVYGVAIAEEEDAVEDVRDRDEEEEEEAQQPKSWLTAWMFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNG0</accession>
    <name>A0A2G8RNG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNG0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="83" mass="9326" checksum="2263372E55024A84" modified="2018-01-31" version="1">MRLSVNTCNAIPADTAQAPHCPYRAGISSPFCRDHAEELHALEERERTAACDADRLKVSVEDMLAEGVKAYIRVKEVRKDERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP58</accession>
    <name>A0A2G8RP58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP58"/>
    <dbReference type="OrthoDB" id="2754381at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="302" mass="33254" checksum="AA8DAA9EF17F6CCE" modified="2018-01-31" version="1">MPSSLDIDALDPNFAPPTRPPSALSTASDTSYFALYEEPAAEQPVDEKNPPAEYLPRRIVVETIRRHGWACLLCGRKDDLAVVRAVLQHGRPQHQHQHENENGIGDGDGGQDPIAWLKSLGLLAPTYERDDWTNLMTLCGPHARAYEDGVWRWVPGAKLRGEMASAVPLRNGTASENSEDEDGDVTMSDITVEELNKGYVESLSKTIPESEEGLGVPAETLVDDGISGNTKNPEIHFKPMELPHFDIVVFRPEAMSPVQNMPANPSTTVWRDWRKLTLNPYIAYASSLSIIGSDSSWDVGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ24</accession>
    <name>A0A2G8RQ24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysozyme</fullName>
            <ecNumber evidence="11">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_14927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ24"/>
    <dbReference type="OrthoDB" id="6590422at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008270">
        <property type="entry name" value="Glyco_hydro_25_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00953">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013963676" description="Lysozyme" evidence="12">
        <location>
            <begin position="21"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL23614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="233" mass="24532" checksum="B68F1412BD0B1049" modified="2018-01-31" version="1">MKLTTAFLVALAVTVATTSAVAVKRAAPQGIDVSHYQGAVNFAAAAANGISFAYIKVTEGTTYIDPEFSNNYVAATNTGIIRGGYHFAHPDASSGATQAQYFLAHGGGWSSDGITLPGALDIEYNPSGAECYGLSASAMVSWIQDFSNTYHSHTGVYPVIYTTTDWWTTCTGNSAAFGSTNPLWIARYASSIGTLPAGWAYTTFWQYADSGSNPGDQDEFNGSLQGLKNLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ25</accession>
    <name>A0A2G8RQ25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14916</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ25"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ25"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="366" mass="39139" checksum="8E30DE8776F6C6D1" modified="2018-01-31" version="1">MAHLMGRAAPPQSRGDALDVPQPAYVYGLLLLNEFSLSIPPHLFQSVLPPGVTPPEEARRDLERAAYLNFAPAQYKLGHACGFTAPPFPFDALPSVQYYPLTSQQGEIEADIALSKWFLCGVEGTFDEDEGLAWTFAEEAARKDLLNPEFALGYGADAQAFLREQHENLTDSKLVRKRTQAKQRSEARGAVGGSRPVPASQRTEIEQHPQGLHARPPRRLPRPQPQAWREGHLADARAPLTGSPSGMGQSAPLPRVDEYANANGQRRASGPAHNNSLYPNAPPGQGQGQPHPHHHQQPTATTAAAAAPTTAAAAAAASTAGPTAQPAQPPLARPPAKGPQTFAEMGIATTKVDDDSNCVVMCIDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQQ0</accession>
    <name>A0A2G8RQQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQQ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQQ0"/>
    <dbReference type="OrthoDB" id="2799313at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="251" mass="28103" checksum="4D762FB2C6385387" modified="2018-01-31" version="1">MSSHHSADNAIPGHGYQPQQGAGDSAHILWTPETCLEMYQTANERYWADHGLRMTHSGLPSYPSQASTSSAGQLQRASMTGYYPIRGLSQMYRILPQEDYVATRRYQPQNPIIFRAGPSVGYVRLVDFYPSYTAATMAPLEGGEDTVFSEDNLSQKQSIRLHINGCRPYEKQINVRNPSNNLRSITRRKLAEKVAKEIHDDFMSRLQTMIGDPSLGLGPGASGFDRLVLIELRHVSRSSWQPILGVLPPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQT2</accession>
    <name>A0A2G8RQT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQT2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQT2"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="123"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="408" mass="45092" checksum="5635A9361EE78BB3" modified="2018-01-31" version="1">MQPADKSNLLRSEAELRLEQSRRDKAQRIKDLGSPIQITGKALALEVRGSVAWVAENTTVVRKLDLETGNTLQLFKGHTAPVTSLAFVDRVPRSGKSDLLVTGSWDKTIKVWDTETKQVLSSTDAHSDFVKALHVVHPLGLLVSSGSDKVVRLWDLSSVGDGQPLKSVGVLTEHTRPVEALETRVLSEKAAVLYTADTMGIIRAWDITKEDDEASPQWKIKLVDELKHHRTRVDDMVHGDGHLWTASTDESVQITPHPVLPPTPGAKAISPIQHPTAVKTILPLSLTSLGEPYLLTGSGDVIRVYDVSSLHEPELIAETDGHWHDVTGLRLWIREAKIEGEPGKVRREPWIVSTSLDGTLRRWKLIELLHPPPPPPIVPSTKTKLADAPMDVLDEQEERELAELMGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQX5</accession>
    <name>A0A2G8RQX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQX5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQX5"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="16855" checksum="26FF1ED7B19B6E22" modified="2018-01-31" version="1">MCRCSAIWLARALPADGELVTLELKEKHAEIAQENIDHAGLTSKVKIIIGPAVESLERIPTEPQFDLAFIDADKQNNAAYFIEAERLVRKGGVIIVDNVVRRGRVADPTNTDSFTLGVRKLLEHLKGSKNIEATTIATVGEKGWDGFTYAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRS1</accession>
    <name>A0A2G8RRS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRS1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRS1"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL24181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="37685" checksum="FE8B46C482DEBE7C" modified="2018-01-31" version="1">MSSSIPVTVDSPAPGPSSPSSSRWPFSLYDRFAAWRKALDLPNPGTSENLAKEAKNTLVNNYLFDGARADLSKSLSMSPGFNVTHSFTLGSQTAPPAYHFGAIFANENLFLHGNVDNDGNVSGRFNQGWSANNVTKAQAQLSSQSGQNFFQAEHDYQGSDYSLNGKAVNPSLADGTGIYIGSYLQSITKNLALGVEAVLQRQTPDMSDFATAYMAKYTSSDRNWIATAQMQGAGILQATYWQKLSEKVDVAADLQLVAGQGRRDALASLAARYELRMASFRAQVDSTGKVAAYLEQRFAPTFSFLVSGEIDHFKNAAKVGVGVMIESASFTPEEMSMMPPPPGSLGMPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRY1</accession>
    <name>A0A2G8RRY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13994</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRY1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRY1"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="465"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL24241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="673" mass="72274" checksum="723252CB178A5706" modified="2018-01-31" version="1">MATSHSLSSPTSQRTVAQLPFSPSNNAPRLPGINTSVSTSATPSSTSPTATSSPPGWAPHTRTGSVISSRSRAQPNMTHIASELAVVPSASMPIIQSRPTAGTTHVGGILPSASFFHPSRPNNIPLSATPPLPRPSTAGSISTAGDSTVDAVRLSQLGPAQNRDRISEGSDSPDHSMEDAKAPTITPSLSSNKFSREPLLPVGGLPMQTSAPRPTIVTQTGPYGRSDSNVSAGARMRGSFEKLFKRPFSFDRSPSSPVSPGPSGAFNPIQTRSAEVSPITFELGVNGPALDRSPTSPGHRKHSLSPLQGSATSINHASFIATPPSHMDPPLSATPIVNKATGKPVRRYELHPSRNRFFLGGRILTGGDSPWAFIGALTVVLTITGVYFGTTCVWWWNNESPAVAAVGAYMCLLTISSMFATAFRDPGILPRNLDPEPPYPATSSLNGSLRQPLPRDLKVRAGIVRTKYCPTCMTYRPPRSSHCKMCDNCVDGCDHHCQWVNNCVGRRNYTVFFTFLFSAVMTLILVICTTALHLYLVAHKFHLGFRHAIATPQGIGSAIAFSLAMFVTWPVTALLAYHLRLLLLNVTTIEQIRNSAHKTLVPDGPAPPNPFSHGSWRKNLVYMLCRPTGYSWLDARGIATEDRREVNPGFLLHDGGGDWPEDVEHARARGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSC2</accession>
    <name>A0A2G8RSC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_14164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSC2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSC2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="770"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="680"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="572"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1037" mass="115544" checksum="CA27456B219D1288" modified="2018-01-31" version="1">MAQRRSSHRSASLQDSAILSHRKLQVRRATAARRRVFGFTNSYIESRPTSHASGSSPPLSPRPVLVPLHFNLRRLPSRIFSERKDDMRNAVNGYDVSIGMKRKRVVSGSENTSGSRDARSTSRAKRRKALPDSSDEEPVSEMDVDAEELWDGSDLSEDEEAMDSSDNYLINEAPPRRLLRLRKDELVELYAAAGLTEDAELLTKPEIVDCIIAARDDVADLPPSSPGVADSGSSDYSSDGGNVAGGEETDFGHRFRNGMRRRATVHELGRGTPRYPSDRSLSMSHLERSSTELSPSNGKRKRGLLDMAATQPVTGVSTRRRGYSNASSSRSSPTSSTMSSVLPSPPATRLRTRKASGEMDLPPSSAGTNKGKSKVKHVGFSDDVEITRLPSPPEPEESDLTDLTEVENSINKLKPSPRRLRSKGSVSRLSHDKSRPDDVHETARRITPMRKAKGKVGNLNESTDEEVEEDELVSDAQEDEEVDELQDPPSPNATPKPKAAPMGRRTPVRNRLRARHLQTHTPPSDGDDEGSEEEGTVVAGEEGDDEGSDEEPEEEAEPAEPKRLRNGKIVADEDVEEDIGEEDEDDDEEEEEQEEEDEEEADDSESIASTVDEADVDADGEEDDEVMDDDDVDLTIATAKTLVRLRRDDLVRLCETRDIDATGTKPQLAEALLHWRDRHCSEATTSAPSSAGTARPPSTARAPRRRNTRSKSGSGSLTPPVLLRPHHVHMDEPRTPPLSTRARERDGEGELELDLESLGLDDREIPPEKLTKLEKIGSGGFKDVFIGRFKGRRVAIAEFRGQLSQMDIKELKLLGDFDHPNIVRFLGVSIPENTRETPVMIVSELCSNGDLFDYIRNVNPPSLYRVLCIMLDIAKGLEYLHVRRPSIIHRDCKSSNILITSKGVAKITDFGLAKVKQSTRSMVRSLVGTVNWQAPELWHPAPKYNYKVDVFSCAMVFWETLQWHVRDKKFPWEGMNEHAIYEAVGAKKQRPSMSGLRKQWCPEIVDLVERMWAQDPSERPDMSEVVQEVEHIKSLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSE9</accession>
    <name>A0A2G8RSE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSE9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSE9"/>
    <dbReference type="OrthoDB" id="2791381at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="441" mass="48449" checksum="86EFE881CDB00441" modified="2018-01-31" version="1">MFQSIVQGFRSSWSSKVLSDDDSSSPTSYRLIGRIVDVRQPIYAIAISPDGQMFAYGGNLISSQSPILILMNWTGKRGPEVRTLKTTTLLEVPDFYPEVYGAVTILHWLDENELLIGTALGFLVIWSESDKKFTVLARIRMQGSGEIISAASSVQGDGFRIVVGMLDCTVGCIDWCMRRGLVYMWNSWGQRSHVFIPRALSIREDGSVRVLSLHNGKMFILDRDTGDCVGSPVSFVDPIGFAAIDEKKELIAIAHSGGFTLHDPNSREGTVAVYKAEKSRTDLPKPIIFGEGRRVVVIGSDHGKAYVFNKRKGGPPIDTLVHSNDPMELVQSVAAHYDGERSIILCATSSSTAHPSISIWERTVPGRQGKRGQHTVQDAAQRLIQTNESVPTLTVWSIVQVGILLCILKFIWNMGPVEAMAGWTKAAWGTEIRSLLAALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSF5</accession>
    <name>A0A2G8RSF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metaxin glutathione S-transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSF5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSF5"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF77">
        <property type="entry name" value="METAXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="273"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="351" mass="38445" checksum="96081F2F2E57D518" modified="2018-01-31" version="1">MEGEGEEEGEEGEEDEEDEDHVFTSASMGASLAFGVYLRNPSYTPRVVSPDSLPLSLPRPLRQFFGLFPLYTHPAVASLDHARRVTSPTLWIHVPWRSDADVLSSDVECLKWQAYLALRGLSDVSVRWDVSVDGALDARLPNLHVPLKTLPGASDEVKASDDGEGELLPAHLIPEWVDGQVGAFDELEGYADEAAKDESRAWVALLEGNVHAALVLSQPSSTSFLSLLSPYQTQPRPLEAALTHPPAPLFGISSLLPAYGAHVDVDAIEQQYKEAIGSLSERLGTDKWFLGSSSPTALDALAFAYLHSILHSKDHTLRFEVTRRVNLVAWERRVQAQVRSAFRTPSATEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSQ3</accession>
    <name>A0A2G8RSQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000060">
        <property type="protein sequence ID" value="PIL24546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSQ3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="214" mass="22952" checksum="B8ABEDC3657426CB" modified="2018-01-31" version="1">MEEPHHSKPATFVAFSAASLLFGVLSSQALVYFRHYPQDRLCLKIFGITRQVATILLLETAQLVLFAVMAWFIILGPGPSPQVFHLVSGAHFLIDGTIIGVVQGLSSYAFDVNSSNPDFLVAVDAITGVVDIVLVISVRGRSGASTDWVTQGKQSGQEADVDEEYAQVFLNVNAGVVNTLWAFVALGLLIAFPSSGIHALVYLTGTTTPPCSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT98</accession>
    <name>A0A2G8RT98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription factor TFIIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12622</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT98"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT98"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="364" mass="40575" checksum="279D00316F3F5781" modified="2018-01-31" version="1">MASPWQPFPLAQLTGNVHAPFYAPDLAVRLICPDCTEYPPNIVDQHSSGDLVCGSCGLVLDNKVIDDGSNLRNCLSEGHEDRVENCSRAGEAHYDPLESFAIHLKFSHSHKASSSSVELLRAVARDHLHPESSSELPLLNGPKKLTTTCEPIVPPKMVADIAKQLYEHVEREGLLLQRRRKHLLRRAARAACLLIAYRLAHVPRTFNEIARLSNVDMHDLKRSYKVLRGAFNIKSGGARAPDDATDDSGTDPEGLLVRFCDYLGIACDLVPFYRHVMKKMLELVQIGNTRRTMTVVGSVIYFTGYLLGRPTSLKEVASVASLKGAAIITLYGMLYRNKGTVVPQKWIEDYRARLEWLPRPSQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTG2</accession>
    <name>A0A2G8RTG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTG2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTG2"/>
    <dbReference type="OrthoDB" id="2745018at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="72"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="612" mass="67053" checksum="D596E2E172592DC4" modified="2018-01-31" version="1">MRLPDLGPLTQLEPEGRAILLAEVLHAGLVQHQESCWMGKSSTIPPLLDSLAQVLSESLAIVRSLTNASASISRLPNEILSAVFEWVPGQVDDASRIATFDCFRSVDVRDAVPLTAVCRWWRQVALATPSLWSTVCDPKAPQLAPQHSFHTRCPGGALTVFCDNHTSDYALSILRMHGDRVRQLYAFGSHSLAALQSPDMSLPNLEHCVVQCASVDAPIPRLPLLAGESVRLRSLTLHGASFLPSSSFPSLTHLMISKPTRLRSGVLYAVGDLLDFISGSPLLRELHLYRLAHSGVETTMAGPPARAELVRLARLEKLCILETQNSNHYPQDPKIIPLLDALLPRVHIPDTCMVRIGQLRPSDLAKCLGCLGPSRRATRMCVESLNDRHYHQRRSLVLADPERAHYTRLDVSLFGPSEGGYLFYLLLALSLPIFRDVRELYTDSSTAYGWPSGAFAALPLLEVVAIRPMPGENARWTGTTRCAKDFIGALEVTKSSGGESSAVCCPRLATLVCGARPAGQDEDEGEDREEAYLRRLVGSRENAGHPLRRLLVWRASGESERGLREYGGDGGFVRAYEGEEAAALACGAWRTPAPPGCPDWMEEQMYHPSVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTH4</accession>
    <name>A0A2G8RTH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTH4"/>
    <dbReference type="OrthoDB" id="3233731at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="554" mass="59093" checksum="92DAD162389DE0F4" modified="2018-01-31" version="1">MSAAITTAQATFTTDSPQAPAYAFLAYPPPQKKRPTQPLPSPPAPKRAPCSPCSPVHPRRRSATTSAIAAWVAAVQPGSPAPLTPRRRSSISSTRRSSYGSASIVSRRPSINTGTPHSASFLNCQVITPCVKDFKHDLTTVGYTSVFVHFPETPLSATIPLYTTGADKARPPPSFNRIPSVPTSPSSPVRPVKSLKHFRSLSALKTGRRARSKPSAVRAPPSPAMKSPVRTSSKAARAQASAAISASKKSKYAKFRPPPLATELALAQLADGGSIEDHIRRFAEAQAKADGATEMTRDGRLVGVADVYRDGMGGVWRDQDEEWEYAHLLSGDDDWCGSEESWVRFGSPAGKPRKSSLVPSVAPSENDDPRRGSVSSQDSDLDPRYAMHAEDTRDDLAAFGSALAPACARRPGMSVLAIPARARRTAKHLRKPEFLLNAFPVPEGVVAPAVSVPTQVGKAPKQRKRPAPLKLTPPSPAFKCPTNPMDAEAVRDDFLAASFAPAPSPKSAVYLRADVPRAVAPLSPRPIQDAGVKKATKLGMRGLFRVMGGKKGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTY2</accession>
    <name>A0A2G8RTY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTY2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTY2"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="297" mass="31791" checksum="DE193D393131B502" modified="2018-01-31" version="1">MPLKIKSSPSPPASPFTWELLPQTPPSDLDRPPSPPTSWLTAHDMKTFGAEPLVQEIGIVKCKDCLKPILRSAILDHADNCAKIRNGGKKGAKGKAAEAEDKKGKKRKAEDDGPNPDEPGAPKTKKQARSRVKGPVDYDKQCGVINDKNLPCSRSLTCKSHSMGAKRAVQGRSKPYDELLLEWNRANNPNWVEPVKRESKAERKERKEREKAEKKRLAMEAAAAAGADGGKKAAAATTGGTSKKKGKAATTTAATAAAIQAAAHVGPADDAYENLDDIDSEAELDSLNDLKSSKLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVL2</accession>
    <name>A0A2G8RVL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000047">
        <property type="protein sequence ID" value="PIL25550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVL2"/>
    <dbReference type="OrthoDB" id="10606166at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="70" mass="7975" checksum="BF9600FEDFC725ED" modified="2018-01-31" version="1">MAAWPSFIRSYRLLGQVGHHFRRNVTVNGTILLHLLVTWAQEHVPNAFIIPQPAFDLPEDVQARVEGDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVY5</accession>
    <name>A0A2G8RVY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_11436</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RVY5"/>
    <dbReference type="OrthoDB" id="28092at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058545">
        <property type="entry name" value="Beta-prop_EMC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25293">
        <property type="entry name" value="Beta-prop_EMC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1364"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="domain" description="EMC1 first beta-propeller" evidence="13">
        <location>
            <begin position="434"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1177"/>
            <end position="1391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL25686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1393" mass="151899" checksum="DF245BC93CB4E18C" modified="2018-01-31" version="1">MPGYALLWLPSALSTMNVYVTWLLRIPVLFFLAGSATSQSGTLSSRNGVYNSSITPANLPWNTYNYCNAPHVNARHYSKPANAPHAQLVYMNAVIRHHKRTPDNLYPQENELNAIPWNCADFPQFSYGGGSPSAQIFHNTDVPSWHPFLSLFWNGTCDEGQLTHEGLLDSMAHGKDFWGVYGHDLGFLESVNERDIFVRTSVETRTMQVAGGFIAGMDPAFVSKAFPVTTQPSPIDSIPPNYPCPNANAIRDAYQAVPAWTAHLAQNTVLKARLDATLGTAGLADWASWYDHFFDTFTSRTCHGHPLPCNATGGCVSAADAASVFAIGDFEYNYIWNAAENATGYNQLTIGVFLQELAQNFRAFRDGGERFRLRFYVGHDGTMVRVASALGFGRLAPLRWPALGSEIVMEVWKSDEEELFVRVFHEGTVVPGFDNVLAAFHSVNGSIAWRHIFEDDDRIVGFRKDDDVVVSLSGTGGAYFRVFDSQSGNLILERRLHDPQAGRLQEPESLGTAVGFGANENGRDVYVLTNGHTLRRIDRHTGEVKWGWTAPDQTSLVVYAKVFATPSTVYLLGLAKSLSSHTLHITSLSTETGEAIHSGHIPSSISISTGLSEAFILGDAKEPQTAPHVVWFEQGKIKALELTPELKAKPAAAKGAVCRKIADVGLSEHGHFVAVAEDGSGRVMKLTPEGLKAIWEYSDSSTSPSRTDSIYSGGLDVDGNPYIARVFWTHTLKTMSAHVLAPHLADEKGLVTGYTFPFKTGEHGIIQHVALEAANPEHYRVLARLVVTTTTGAVQMWQQDQLQWTREEGLADISVAELVELPERKTASHSESEQETFGARVARQLLDAQGFPQYAVNFVRRFVTGSYASVSASVAPPADANASEPLARDAFGFRKVVVAATPYGKLYGLDSANGAVLWSRVFGLGWAAKVGGQVIPAKVFVTRTVSDGEAPQVVLVAQRKASNGLVDTVLFHVDALTGEDARAQSPSAAGDVLQGDDAIAGPLVEAFLLKTGAGRTVVLLDEFLQVHLYPETGAAKQAFKELAPALRIPLRAGPPGQRRLVGHQVPEELEFTGRHVAYPTWALPFPADQDVLALFARPAGDPVASLGKVLGNRTTLYKYLNPNVVGVLTGPPPSAAAASDRATCGVWLVDGAKGTILYQAVVPSAGGRCDVKAVLVENWLVYHYYDDDVGVNQAKGYRVVSVELYEGKGIDDKRKSSDMSSWSNGTADVSVYEQAFVFPRGIRTLTPTSTSYGISVKDIIVANDNGQIQSFPRRFLDPRRPKHKPTAEESEEWLIQYDAVLPDDPKRVLSHHYQVAKTRKIITSPALLESTSLVFAYGLDMFFTRVAPSSTFDVLSESFNKAQLVITIAGLALAIVVVKPIVARKKLRERWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWC9</accession>
    <name>A0A2G8RWC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RWC9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013641186" description="Transporter" evidence="2">
        <location>
            <begin position="20"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="25848" checksum="162F9A3AAA48B18F" modified="2018-01-31" version="1">MMHLLNFVLAALVVGRVVAAPAGPPSGVPSGLPFPSGAAPSGVPSGFPIPSGVSGIPPPPPRPPVCPPACPPACLPVGCPLAPSGAPPSGAPSGFPRPSGPPPSGAPRPSGAPSGVPPPPPPSGAPSGPAPSGPAPSGPAPSGAPSNERRQAPSGPAPSGPPPSGALSGAPKPSGAPSGAPSGAPPSGAPSGFPRPSGPPPSXXXXXXXAPSNARRQAPSGAPPRPSGAPSGVPRRPSPRALLRLAHPFGCSFRLPEALWPVPVWRPLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWH0</accession>
    <name>A0A2G8RWH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWH0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWH0"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="15143" checksum="69367CE7235B14C5" modified="2018-01-31" version="1">MSLPKTTREYRLPKMDGFHNLTLQGATIPQLKSDEVLLKVHAVSLQYRDLAIAKGQYLPGVKANVVPGSDMAGEIVAVGAAVAGWQVGERVMPNFSLGHVFGEPTVEGGKTALGGPVDGVLTEYKVVPAHALVRIPKHLSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX13</accession>
    <name>A0A2G8RX13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX13"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX13"/>
    <dbReference type="OrthoDB" id="4018688at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013715125" description="Survival protein SurE-like phosphatase/nucleotidase domain-containing protein" evidence="4">
        <location>
            <begin position="18"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL26059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="303" mass="31619" checksum="9918DC7C9D4B0ABC" modified="2018-01-31" version="1">MRSLALTLSLLSAYVAATKIVISNDDGWATAQIRQQFDTLTNAGHDVILSAPAFNQSGKGSLSKTPTTLTEPCEYDTCPTGSPATGFNASNPRLNYVNGYPVDAAKFGIQTLAPQFFNGAKPDFLVSGPNIGTNLGLVVLISGTVGAACEAAREGIPAAAFSGTTGSQVSYTTLESDPTAASSLAAQIYSELTADFVKAITSTPGPLLPDGVIVNVNYAAIDKCPSAASYKWVFSRLMWNIFETDYTTCGSSHLPHESDVVSQGCYASVSVISSSSKLDVNASLQGQVFDRLTSLPVTCVGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXT6</accession>
    <name>A0A2G8RXT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXT6"/>
    <dbReference type="OrthoDB" id="2757813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="403" mass="43128" checksum="CA949CE17DD5FDB5" modified="2018-01-31" version="1">MSSNLRYNLRNRASGPRPGAHSGLAPLPDSEHSDAASAASSARSSSVWPGVSYSQAASHHVGADTASLSDQEANPRVSGGDTVPSNGREAHPRSSAPQYGTAELSSLSSSDKENISSSFLSHEMGSSLTTMNVASEEIGNGQWTEVRRRKRRARSLDSATPQDVTPPRVAVVPPAGTTPLNEEQQRAVRAAEKSLNKEERGRIAKRMRAVSNPRGQSSSRGEGPSTMAKGKTVDARNWGAVGIDPAELDPKAQREALAQFSAHKAPDYYNSDEDSEDECEAQDAVLQYYAAIKAAKQQNKPSVRTVTDESDRGLVARQARDRSLAGQFSTRSSSRIEATSNKDLERQIAALRKELAEVQRARSVSEKSLRPHAELLRDGQSTTSGLQAPSRDTGVVSSDAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY29</accession>
    <name>A0A2G8RY29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY29"/>
    <dbReference type="OrthoDB" id="2756044at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="37777" checksum="CB7AA18AB50A0B3C" modified="2018-01-31" version="1">MSWSTSEANGVPTGLPPNLDPASLLRDEVTWLVLMTTYTAFLVPIAVVLLFFSTPQLRRRPVFILNVCTLALGVAQGIVSISTCVNSLLFNLSATPKTSLASIFLFMCAPFCVQGILILRVLAAYPPKTLSSTRAFTIYGPIVLFKLARGANIGYWIFHLHQVIKDSGGLSTNTVFTVSQAAWTFPNTKAEWFLQLFDDMYDFQPSLSHSSSSTLTNITPAGSSPNSYVQRLKTLFWTAVFNFVFPVIFNIALLVLLFRDHDFVHGSYLLYTNNYVQIIGVLLATVFVVGRQAELKGELPTGQLAHSAHVEFGYATHVQSVGSSHSHLVPMESKRSRGNSEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYA8</accession>
    <name>A0A2G8RYA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYA8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYA8"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38847" checksum="82DC80DB3EB516DE" modified="2018-01-31" version="1">MTLDSRSTKRRRVSDSPQTIVILPPGQSRKPAKGQEQFTRHADFWLDDGNLILIAGDTAFRLYQGLLTKSSAVFADMFATGSADATETFDGCPVVRLPDHPADLGDFLQCLMPCSEPRLYDGLPVSDFAELHAAIHLAHKYQCSHVETRVLSVLKRYYTPHFTDYVRYSTSKPHMLAPARSAAVAAVNIARLTETVSMLPFALYHVCALEGRMMDGYKRRDGSVEYLSTEDLRLCVGARNILAREMPSLVKTVFQKKPSPRCKTAERCAAALVDLRDDVELNSLGECNVLDSFEDIIETWAAEFELCMACKKEMLDREVTARRELWELLPDVFGMSIKSCGFTSTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYP1</accession>
    <name>A0A2G8RYP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYP1"/>
    <dbReference type="OrthoDB" id="2929525at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="245"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="398" mass="44287" checksum="ADB89C8945D7C0D5" modified="2018-01-31" version="1">MPASTDAVPAIPTALLSISVDDTIGATLLATFFALLFYGISLNQLYRYLRRFPTDDRFVQVIEGIYSDVRLGTPQSSFSCSYNPYPTRVSETVHCVSTMHLSYFMAVSSLAQELTFVRHGLWSLKAIAISSAPIIFVTQMFFARRVWLVGPQYRLIMAIGVAVLLIEFGMSQLLSQDGAPHAHYLPFRPRMIPTGFGIGKHFRGFYRLARRTDRRRDDYARQLLVTRRYDTGGVRWLVAAGLTTAFATDLLFTPTLTVAIWRSRRGQKGNNSVAELFNTYVINTGLLHCIVNGAASITCLTTSPYSLVYGIPQMTASRLYANSLLSALNSRDSQKGPTIFDSGSYGRNLIQRMNQRAAAQTWNAPQIPDEPSVIHINVTTENEGARRDSAFKRGLAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ48</accession>
    <name>A0A2G8RZ48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ48"/>
    <dbReference type="OrthoDB" id="2755014at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="423" mass="45906" checksum="08D5A6700C223B89" modified="2018-01-31" version="1">MAESAILAAARLSPGPPLAHPHILASDASAVDTPQPHVTFAAATHHSSLVLAISPCDRLVSSLHGEVFALVAAALLHLHQPVLPPPAHPPLYTDHLNSVRFLQTYPTPFPFSSPPLNPALPLYDWLLDILRRTPNPPDLTYTPAHTSATSPQAQANHLVDRLASSAHSATSPVLSLPLPTFAFPPYVLHVPSYGYALLSSVPSVLDNLTTRSQLSDASARPNSVLFRSLYDTHSPPLHPYTRASSAYSALVQLYVRSSQLDDAFTRCRRFRDASPACHFGCDVLETPHHIFVHCPQFAAVREEALSAVITETSSLLDRAPETLPSSDVILHAARSLFSDDPVIWPQTLSHYFYGTVPPLPAVSAALGAHPPVRRLLSRIAAAWHSASIRLVARIWGSYKRILYPLPSRAPSPLVLPPHIAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S084</accession>
    <name>A0A2G8S084_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S084"/>
    <dbReference type="OrthoDB" id="10465163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013943383" description="Transporter" evidence="3">
        <location>
            <begin position="26"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27493" checksum="111E63AD1C8D1E77" modified="2018-01-31" version="1">MRYSFTSRPIAVAVTIVIAIPLTSAAPTQSSMSSFPNAVRRSNQDSTLALRDLAEHEAYSQVLVTPSHSASPHMAIPTGGMLLEANRGSNLATVNTVVGDSCTPDLHGYHIAVLVLLSCTFVIATFNAFYSLYRQWSFNRRHNRNWPSVNVFSPPGTPKRKPRLSLSLPDIEKAMPLRHKTSTSTLPSISEEPTTPARVVSFVSPHESSRPPSYSVGDTSLLDSPSVGCFPMSPNASSHRSFTEGQSSFHPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0H8</accession>
    <name>A0A2G8S0H8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_10399</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0H8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0H8"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL27255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="483" mass="54936" checksum="50C1ECF1CE7950AC" modified="2018-01-31" version="1">MSSYSVSVTTTPAIKNAPLIGLAEGNGYFSNAHLAALVLGVPWLVKRTLPVFCHGGTKTYLFLVLLLGIPITAGYWTVMSTYGPRKNQKVQLPGRNIDEYITIKDPELKAKYFGKEKIPMQVFHDAFFDDKAEFNGDVLDILESRHDWAKMVFTPELFKYVLTRFLPEVIVHSKSQDEEQVRDHYDRGDDFYEWFLGPRMIYTSGIVRDLTVEESLEQLQDNKLVAVCEKLDLKPTDRLLDVGCGWGTFAAFAHKNYGCDVTGITLGKNQTKFGNNRIAANGGDASRARILCLDYRDTPGGRAAYTKIVSLEMAEHVGIRRYGAFLRQMYDLLDDDGIFVLQVAGIRPAWQYEDLIWGLFMNKYIFPGADASCSLGWVINQVEAAGFEVKNIDVLGVHYSATIWRWYKNWVSNKEKVIEVYGERWYRIWVFFLAYSTIISRQGGASVFQITLHKNLNAFHRILGVPNHNSIHVHPERDILTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S172</accession>
    <name>A0A2G8S172_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S172"/>
    <dbReference type="STRING" id="1077348.A0A2G8S172"/>
    <dbReference type="OrthoDB" id="642895at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="785" mass="86821" checksum="46DB866070979E78" modified="2018-01-31" version="1">MSTTITSLLNSLHTHLQSQTQLLPTLHAQLGLPPTALHDELSALQQQLTQCIEGQIDLRRKQVDEWMEKCSTVEEDSLRYGKALGSHLKSSGPSVGEIRKEQVLPRRFELISECQEKLRQQYHTKLEQLLNITSRISSLANTLGRDFYASDILEPTPAVGEDEYDSTSHRDVTPERFSKLEKELVRGKGEVTKRLHQLSANFVQIDWLYTELGISPPSLHDLPSASSSTLGLPPLPRPSSSCGSRGTHSDPFLSTSMSIPMSTPTPACRLKPLTPLLFMSDDTPHTTETDHQRVFAKFVARMEELSDEDLPESNTAIGLEGVEPTPALMAWAEATRTDLEETKRRREAHIQTMYDQLEALWRRLGVTDADMDAFVEAQRGTTDITIKAYEEELERMLELKRERMGTFIENARTEITKLWDDLMVGEEERADFAPFVDDEHTEELLSLHEEEIKRLKDERRLKGPLLNSIKKYFDICEDEKELAAAASDQSRLLGRGPRDPGRLLREEKMRKRVTKEKPRLEQDLLVSLPTWEAETGRTFLVHGISMLQFLMETVSAADKENANKRTKGRAGSVPPRATTPNTTNHLAPPTSGHGKSGVVTPAVRPASTLGSSQSVPNKRPRLGDSTSVHTNRAPLGSNRGPSINRAGSPTKIPGPGKTPISASSSLPRPVPLAMPVPKPGSAHHGLGHGRVPSAQQLGASHAAYQPSHRAVSYMSTSSLSSSTYSSSRYGGPAVAAVVAKKASRARRESFKPRPSVDENWAADVALGGRRWAGLTGTVQEEDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S201</accession>
    <name>A0A2G8S201_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S201"/>
    <dbReference type="STRING" id="1077348.A0A2G8S201"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="63"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="365" mass="39742" checksum="D38EEDB5A384F3AF" modified="2018-01-31" version="1">MVASTRKIGDAEFSTIGYGAMGLSTFYGPTLPDEERFKAGHLHICAPGEPRPNIDNPFSTHYLQVLDSVLESGYTHIDTADVYGDSEELIGKWLQKSGKRNGIFLATKFGMCLGGPLPDGRHVCGDPEYVASSIDRSLKLLQTDHVDLWYLHRADQTVPIERTVAAMAEQVKAGKVKHLGLSEVSAATLRRAHAVHAIAALQVEYSPFTLDIEDDKHAVLKTARELGIKVVAYSPVGRGLLTGRITSADQLDPTDLRRYLPRFSTENFPKVLEIVDVIKGVAEKHNATPGQVSIAWLLAQGDDILPIPGSTKPANIKENIGAVNVTLTPEEVQQIRQAADSADQTIGLRYPEAYMALVMADTPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2T8</accession>
    <name>A0A2G8S2T8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_09840</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000029">
        <property type="protein sequence ID" value="PIL28086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S2T8"/>
    <dbReference type="OrthoDB" id="2755185at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="300"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="1070"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="755"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL28086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1400" mass="157155" checksum="A46F9BA2B1ABF48F" modified="2018-01-31" version="1">MADASAPMDGSVLTEAGELVRAKFLAYFDDEEAEVAGLNPEERFSFWCTETTVEVTDHLPAVSCQQSFLDSYEITLEHLADPPWTVSDAIQEAWNEWVAMPAPPDWADGFPDCRTRHKGHPALYWLRACIDKYMTAEYPQLTGTQDLMKVNPYKMGYLLSSVANDDKYFLTHATVHAPGFDITPYAAALVEGHTAEELKFFVDLVSIGSPVPVDICGEDVEVVSSAAADVLDDELEKLWEQLRAEAKDLCQDGATAELPPLREINHPILLIDESKVYSWRPSKCPEALKPVWSAKKRAYLASGRWQMASGVNASPMLILKKPSKGEDDIRIRTIVDKREQNANTHKLAAPLPDIEGILRNVVKHKYRSLIDGKDAYEQIRVVPEHIPRTLFTMPDGTMVSLVLQQGDINGPTMYQTVMNHIFAPYIGVFMDVYLDDIVIYSNTIADHIKHIRIVFDVLRKHKFYLGADKMNFFAMKLKLLGHLIDENGIAMDPHKVECVQNWKVPTNKTLLSSFLGAVGFLAPDCEGICIPMGVLAQLTSSARPWNWTDTYQRAFDQVKEIVHKWRNSRRTALDYLEGAPAINLVTDASLTGGSGYICQGDDVLMAKVILFWSGKFNSAQQNYPVHEQELLAIIESLKWFRHLLYGTEFRICMDHESLEHLMNQKNLSPRQHRWMDVLNEFRNKIHYIPGELNVLADALSRLYSDEPDGIVRAMSEYVGRDGSDDRDEEPFMDILRPVYTGAAAVVDFQPRRSTRLAEHPVPEGTYCALHEGKPRTEPEAGPSRPRRPKATVENAEDSGDEPPAPAETPTAERPVQEPDSQPDSPTIVSTAGDLSMQLPGAFRGRYSEDTYFRKIVSSPSEYPLLVMCRAGPGSNARAWARLWGARAHSNLEPGPQRRLRLGSAGLGLKPGLLACGSHLKLHFHVNYRLGLWRTPSRALKPSKPAIGPGWAQALRAGYPGLQGLKPSPAHHYPLFEYNDGLLYKKHGETYLLCVPDILHGTRRVREILIRHTHLILAHLGYRKTLDALRGEVWWPEMVSDTEAYCRTCGICATTKSVPARPLGMLRPLPVPRRPWQYIALDFVGPLPLSSNRLGDFDMICVIIDQLTSMVHLVPTKQTYGAAEMAEVIFDHVYKLHGLPERIISDRDSLFTSIFWRTLHGLLGTELRLSSSFHPQTDGATERANRTMTQMLRQCIRPDQKDWVLCLPAVELAMNMARSETTGFSPFYLNYGQLPRSLVWAAESPYPGVQAFATRMKDAIMSAHDAIIGARIAQTEQANKKRRKATFQEGDLVYLSTKNLTVPKGRARKLVPKFLGPFSVTKVIVEGATYKLNLPRASISCGLVNAFHASLLRPHYPSDDRRFPGRQYHQIPGFGDNPREWAVDRIVVARAADGGEETRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S351</accession>
    <name>A0A2G8S351_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S351"/>
    <dbReference type="STRING" id="1077348.A0A2G8S351"/>
    <dbReference type="OrthoDB" id="2985259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="80"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="457" mass="50764" checksum="54224C6767457433" modified="2018-01-31" version="1">MPTTEPFLGVDSARAESPTQSFAPLKPSALRKQLPADLKTWRGPAGLDRHYEPVEAIWKVLEPFFAERGYTLWQHRDFFMTAVSRGGAVSNGFMYATPHRAYEKLSGSIQRVLSYEYRNALTRAARTPDGRDVVFRVLAIGEEGREHVDLLKTLARGTYSLISANHTLPLLELIELDDITFGVFPKVAFSCSELYHGWAESSVGDILEMIAQCLEALVFLHTCGIAHRDAFKDNFVIQWVPESLRIDYDSPSSRPRVYMIDFELAIRFPLDSPKEARMCVGRPSGGSLPGPSGRPMPPEVLSGEPYDPFKLDVWQLGNSISDFKSTIPEIDKVLVSMVDPDPTSRPTAYEAMKALLDAVGAIPPGQSFNVIGSDNIPYFGVAIKTVESGGGIGYVLRFADNERRSFLRERCEPTEAAATTSPPQEELPNALSETEPNPPDFPGIHRRTRARPYLNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4J4</accession>
    <name>A0A2G8S4J4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4J4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4J4"/>
    <dbReference type="OrthoDB" id="2748371at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="20033" checksum="BBC6A39712CABAAC" modified="2018-01-31" version="1">MTFFRFSKYHPRTDEEKTKTSNVWMKGHTDSGTVSLLWSQPVVALQILSPDGQWRFVKYVPNSIIVNVGDAMEMLSGGYYKAAIHRVVQPPPDQRGYTRLGLIYFAYANADVKLVPFKESPILQQVGITRKCDDEDAPTMKMWGSMASMYRHSAPKKKENGIEEEVMNGVVVKHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5T7</accession>
    <name>A0A2G8S5T7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5T7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5T7"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="82"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="234" mass="24813" checksum="8F4440E764C1D355" modified="2018-01-31" version="1">MGISVFLHILIGDSEQHARETAAYTSTATLLAKNAAIYGLPSLPAELSEEQQGILKELDSSLAMRFTPPVPLLAGKLVFDLDDTPGLANNFVALCTGEKGMCKNAPNKKLHYADCPIHRIVTGFVAQGGDITRGDGSGGESIYGGKFNDDKAGLKKKFSRGSLAMANSGKNTNSSQFFLVLTDDESKLAKMNGKYVVFGELKDGWEVLDRLDAVGGGADGKPSVRVWIGGCGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S619</accession>
    <name>A0A2G8S619_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S619"/>
    <dbReference type="STRING" id="1077348.A0A2G8S619"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="66604" checksum="7543CD36968380B3" modified="2018-01-31" version="1">MSERHTGAFIYGDGSELHDQCAVYPQAPPANDCDSDHASDCRTLRENEEVSSTSSPGSSPYEVSKLEADLYYFGIRGPRFLGPKLIFRTSKDVFTPPVPERNARRMQLIPVYEHNELGRDDLWATVRSKIVGLLDQRNIKHSSVDLVRFRWVEKNVDNEDNGDNETNEANEGNEGGEDESDDEDYEGDEEGEDESDDDGGDDTEVEDVDYEIPSVLSGPKLFAPVSDFDPLKAVIDPMTTALSLPIAGLKTLDNEGTMGFYFRDGDALYGVTARHVLFSDDEGNDSYTYIGGPKKEVVLMGGRAFTDFLTSTQHRIEVLNLVLTSLESQARTTTRRLESSGPNAEQMAHGLAKTEAELSDVRVEIEEVSKFLMNIKKEWTKPKDRVIGHAVWAPSISVSTPSEGYTKDICVVKLDENKFSQNFRGNVLDLGPEKERAHFIGLMLMCPRIDAPPDFEYPADRLLKLRGILSAQEMRTTTNKDCNGDPMRYVIKRGLSTLTTIGRLTGFESHVRRYQTFGSRDSVEVAVYPYDQHPGPFSRGGDSGSIIVDARGKFVALLTSGTGSTESSDVTFGTPMHRLWEIIKAKYPGASLYFEGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S697</accession>
    <name>A0A2G8S697_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S697"/>
    <dbReference type="STRING" id="1077348.A0A2G8S697"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="98"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="586" mass="66941" checksum="898ACD52CB801A9F" modified="2018-01-31" version="1">MTATPPSVPAFPSPFEFNFRHPVPLLELRMSKLSGQIRCKPNWWIKVQDPEVVAKWRAEIVEQDAAVVDRFWGGPKRLEWKLSITVEKQWPRSKITDAQLDYIFDQLRFEATRYDAATGIFATAVPKVYESRSLIPVTLKAPLVDGVSVLESVPEEDKDWHPGSNKQVLDLVHPSMYCLRIGQSYVRPRGDALDAASGAVKVITEKEYMQQRPDMNKFRRPEMDYVISPKFQWLPTDFEVSAEGGVRALSYINNLHPTHHRALYPAISSILARFIPLFENVLTDAINPEPQNAVRPNPHEWYNHVYSENPDVPRPYDEPDPEDSTFKDENGYWYGRWPYVPEPVPFQPPSTEGRTTVSLRGRTLQVIVKLANIVLTPDNPAYPGGSWHVEGMANEAIVATGLYYYACENITESRLDFRAAVGSEENGVHLAYEQSDDTGYMTVFGLQRESLLNQPFGGIVAEEDKCVAFPNIYQHRVDAFELADPTKPGHRKILCFFLVDPFNRIMSTTDVPPQQADWATEALGGARTLQQLPQELFDIVVDYARDDKVSRKEAEDVREQLMEERSTFVVDHNKELFEVEFYMCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6I0</accession>
    <name>A0A2G8S6I0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6I0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6I0"/>
    <dbReference type="OrthoDB" id="2744906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="45124" checksum="9872984D0786C2EB" modified="2018-01-31" version="1">MPSLASVPPEILAEILGWLSSDVGSLKNCSFSCSALLPVSQYYLLAVVDFSFLGDMETEPLRDCITELQVTPNSEPLASDPETYINTALSLPRLNTIRFNWGTSPLQPAFATAVQQRLHEFTSVTHLVLRGMVYSNIDELRNLICSLPSLTHLTVGGLLFRDRRPSAGNYFMRHRKLPDHPDGPRLTYISVAPGYNAEATTAILEWLPCTPTRDSMRTVEIPEESRNTIFVVDCFGPSVYHLSIAKLESIASWKMGFISRYTALRSLELGAMSPASWQQLYKMVAEIRSPHFVELVLRYDAVADPDAAIAPNTVETSPVDYALRVKLPSVKRVCFVVVYDPQVTGSGGDTVWRDGVVTRVRACFRRLAEGGKLQIEFEHAKINNQKLRQEQTVFRTSRNRTIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7P6</accession>
    <name>A0A2G8S7P6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7P6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7P6"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="31311" checksum="496DD90BB56B7E81" modified="2018-01-31" version="1">MVDLPLSGEQILISVDGTKIWAESTGNPSKPALIFIHGLSCSALGFDRQFTDQGLLESFHLIRYEMRGHGRSGQPLEVEAYQSLRYAEDFKTVCDAYGVDKPFLVGWSLGGVIAADVLNAYGPAALSGIIYCGGGMPHLHYMAATTKPSLLPLVAAITSERADDMAAAASTFVDSCTAQPLPYAVKLQWMGAFVAQARAARVHSIERAQDASAEWERRARDVPVLVVQGTEDQHRNWEGTRSLIERVYADVEVYMLDGVGHTPHLEAAEETNHAIGAWGRKVIARASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7R1</accession>
    <name>A0A2G8S7R1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7R1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7R1"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="50"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="544" mass="59690" checksum="6468AD05CBBCAA31" modified="2018-01-31" version="1">MESNPTVEAVLDHLPNLEKDSTRGYDLNEQRRATLQEVDKAKFSWFHVRVCLVAGVGFLTDAYDIFAINIASVMLGYVYGHDQALAPNQDLGIKVATPAGTVFGQLVFGWLADVFGRKRMYGIEMMLIIVASFGQAMCGQAQAANIIGVLVVWRVVLGVGIGGDYPLSSVIPSEFASTNIRGRMMVVVGANQGWGQFTAALVAFIIIEAYKSSLLHDDPAVLTHVDFMWRLLIGLGCVPGTVALYFRLTIPETPRFTMDVVRNVRQASRDVENLLTTGSYYAEEDSVVERVRAPKPTKRDFKKFFSRRKNLVPLIGMCYSWFAIDVAFYGLGLNTSIILQAIGFGTPSVNLIGTARVYHNLKNIAVGNMILSAAGLIPGFWATFLLVDTWGRKPVQLLGFTMLTILYAIMGFGYHKLTGSARGSKVFVFLYCLTNFFSNFGPNCTVSIFPGESFPTRYRSTAFGIAAASGKVGAVVAQVGFGKLVNIGGKNAFVPHLLEIFAFFMLTGILSTLMLNEGKQMTLETLSNEEQDEFIDGEFSHVPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S803</accession>
    <name>A0A2G8S803_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S803"/>
    <dbReference type="OrthoDB" id="2758490at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="132" mass="13927" checksum="C5B34703E8474815" modified="2018-01-31" version="1">MHVMLYNGSVYLLTVTGANILNLILYQTSSGTLSYAGAITSSLNSVLTCRFLLDLRQADRRATAPTSPSAASSLDFNVVVAGSSQTVSRRSLPAFVASMGSEVPTGLDFVDVIARDPDEANEEVSREVGALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Q7</accession>
    <name>A0A2G8S8Q7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Q7"/>
    <dbReference type="OrthoDB" id="2755060at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="64135" checksum="22532772FEAB4C1B" modified="2018-01-31" version="1">MDIMLAILSHSPPKTATSIMETCRFLYHEGAKVILQKDVFIDGRGEAVPPMVRFIQAEDLSRCSYVRNLWIFFVTLPEAVARALAVIVPRMCNLVNLSLCIVWQRLFDVYPYLLPAFASLRSVKNLMVRVGSYDLFRLIQSELVTANILSMTNNQPGTGQLPSSVSCHPVYLLQRSASTLQELICSDIKTVGRPPRIIYPNVHKFALQGNEVPFLPPYITAFPNLVHLSMTGHCPLIGGLPRPPLSQNQTQTTTTPHGLTKDPLVWKHIQTYTGTLSNLHAVGITFPIPRLYLEALPGAPYIPALTEVLAHVQPVHLTITYEDQPFSHVPASPDLLAALRSDGASRLQSLALRIDLMAADVDSNFDVGQFWTDLEAALKRLKLSALCISMGDISLSETVTASTAALRLPSTADGMQQSTHIHVHTRAHTDRTASRSSSSSMYDAPVPVTVDGPDADPSTRMTCPPDCSQCAEARRASLTLAERTLEDFDVGAFVDRLEAAVPTFQRAVVSVVGPSRWPGGPGPTGRARTAHLGKHDGLPSEMRVRVHDDFFVDREAWVREFMKPVRPFAAMARAWYHGQAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8R8</accession>
    <name>A0A2G8S8R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8R8"/>
    <dbReference type="OrthoDB" id="3263739at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1110" mass="123783" checksum="B2FA7F7652A5BB41" modified="2018-01-31" version="1">MPEADIIFGVERMIKKYQYKYPKYLRGRLALFPSMFPDVADTSLESICSVVDLGFDHAQHPAPDGFIPDPHDASRSKGEAWESFLKPLPVGNVFVHARGRECLVTAGPLALVFRLGVGDAGLMLKREDYEELVRARVPRVNDGEATPGRSRSFVIPHHLTVEGNRLANPGDDRPQTVNIPAAVVGEDLVFVIVNCSHNVRLKIVALDRGWTPEDLRPDSKLWDKLWDESYGPCWIKEPDVALARLERWRSDILNTSPPDTNASLVKELCRNQAVFNGFGKHLACDFLHEQCLWPGMPLHALCADDALFHTFKDGIVEYMQRWMSQDYWHDCLGCYNLDRPFAHNRNSDQRYLGRHVQVFRKAFAADMPAELYNKYVERGLLNPDHVIGQPCTPQESELTQGKMKRMVPVYVYADPDSTSSEAPYKFYTIIRARRPDSWGMGWNASVPRCPGDARLPGSPTVFGPASSPIHKNNQLDPTVALKPGRARKHRDGKRGRPAKDRSKAQLNRDSEALERLRQRVEERMQEDEVAEEVAEAQAERPAKRVKTSSLNLDVLANVCKFLGEKSDILSVSLTCSSAHAFAVSWLLSTHPVRLKSGPSIHHFRSFLLANLPARAPYLLALHIDLTWPQPQADDTTPLVEILASCNNIEHLTIAFQKASWPTVTDPRFLNAINSIPSLSSFTVRGESIDALALLPGLRAPVRTLGIQSSNITLGTSRHPAILGQFLPRGLVRTLEALKLDRFTVDPAHGGVDVQAIINLPCGLDMAPYPAIRSLFVESFKGQAWLHLLQHLFPALDGTLCLGGGYSLDFPFNEARFSGLLREANYASQSESNADGVSHTWKKLDRVICGAQMLYVLGLRCPIRLLMLESVFTSEDHRYAADALRENPVPRLKLSALHDLGPAFGDVFSPELAGTLTHLTLCLFYSNDYGSESSPSGEGEVLQWDTVLAGIVSAIRPLHNLTHLHIVIGASVYVHKVAPWPFAPEKEYAHTFRESTFDWEGTASTLADALPSLRNVFLTTNGFLANWDDEPGSCGRWQPYERWHITRGWRVGDPSTGTDGAPEGERTLVQLHDNIMETTVRKEELVLSKLDEAALHLNYGWGRTPPPLSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Y2</accession>
    <name>A0A2G8S8Y2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Y2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="679" mass="73726" checksum="3EC801C6AF9CB042" modified="2018-01-31" version="1">MVRIRSVQTRLLRWAGDTLPDLTPNYYHHHHPLAALALALSGSAVVLVPDPRPPPDPMAGPEPAIIPFMMNIHPFYETVRLRSDDPDSVTVKAILGWASRWIGWDDGSLSLRWITDEGAAFVPKDDSDLDLHGIVGSGRLEAAKAWYSDKGHSLASEPIDTDHSLRKRLRSARTASGSGTSAGEPEIRLYVVVPAVSKYLGAKDGGVVERERETYSLDHSRSQRMDDHLWGPSCDLEKDDSIPTRMAALYHPAFAYAQKALRGLQDGLPPEHRDREPGENASGVTGSVGAPVAPIDGGKDDGVLEGRRFIAQLRDALHGLSVVEVGHSGLDSKSKEAASAHAAALGKVLQELFDDHTLKVEVTPRGGGIEVEVEAACPTPYRIPACYIVGKDKLVSARGSDSRSGRAPNVPESMVAYRDAMLDDKHVSIFAATCCPCLVIGTLGSTVQIYAAFFADWVYRTHLCDFALDATDPNVDEKVRIIRNTARMLREAYARLHVGVSLGPPKHALLPWPAILMPAPLPVHLYLLDRVLLGQSNDLFTGKLKLPGPLNNNDGGDGDRSKESSRPEVRELPVHVKFTDNYGVAAHRLLAAHTDASGAPRPLAPQLYWAGEVVPGLWMVVMETLARWDADMPEDGVDCSENFALPKSPRVLGGPGVCAREEESKKAVDYRGLMVSIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S934</accession>
    <name>A0A2G8S934_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_07443</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S934"/>
    <dbReference type="OrthoDB" id="1750432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="744"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="194"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1191"/>
            <end position="1295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1307"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1321"/>
            <end position="1331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL30265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1715" mass="191889" checksum="7BD6EC31E039D236" modified="2018-01-31" version="1">MELCTVVVTPRQLRLLLRLHLSLVTTIGLMDKLEDTGVVVLRHAATVTSQESMLGMSTVHLQDKDRIVSMVIGMEGGTETVVATGRRDRETVLPMETKGLLGSPGHMARNCPQNSQVQSNNAGQAPGIATYNIELIPDDAEALRNLAESTSATTELHLNSVEFDYSALPRLQPAWELLEPRYRADRLTGFVSIGDPSEDDFEGMFDDMPSLQSVSDSSSEPSEEPGQESDDTRSVISGPKPRQRPRTDSTSSVGGCPVPVEDDGIRVQEFDWDELKFPQTRAEGASSYALGNVFEQRAVEVLNRYRPYWDGASTEEEHEFFLVHQISHSTYAVENTASDLEFFVTAEQLNNPNLDLPNSFRQMLRAIRRPGDPDILEGASEPLGDVTARVLEQRLNEALPWPEYLRCKPAERRFQCFQLGDLVEIQDHYLALSVHIGCDLLRNPRLDFRDWYAHAARRAHHDRVAETASEVVASDDFGCDLDSLFKEQEYSELLSEQWYAQAKPYLELNAAQRGKSRPEPDDLIVQRNAAALRDLRRVIPEPIVVVVSINGHPACALLDTGSLSDFMSAKLAHQLGVKTFELAKPMPLHLAVQGSRAKINYGCTAQLEYQEISSKCYFDIINLLNYDIILGTPFFFQHRVLAGFNPVKVVVGSAKPLPVEGKQARVLESRAAEVFADRLESARQELREYAAPICMDASDSPLPPLRTINHTIPLKDESKTYSWRPSKCPDALCYLWIEKCEAYLRSGRWQMSNARNTSPMLLLTKPGTGVKGVPHRLRVVCDLHERNANTHKVTSPLPDMEAILRRVSRKPYRTLIDGKDAYEQIRVEPSHVPRTAMTTPDGNMVSLVLQQGDCNAVATYQTLMNHIFAPYLGVFMDVYLDDIAVYSDTLEEHLQHVKLVIDILRKETLYLSAMKLRFLCREMKILGRIVDDQGIRMDPEKVDNVLSRKVPTNRELLRGFLGSVGYLADDIATVRIPMGILSSLTGSETSFKWEFTHQRAFDEIKKLLHAHREHHRVPLDYSKDAARIWLVTDGSHGGIAGVVTQGEDFRHRNVAAFFSAKLSSAQMNYPVHEIEMLAGIESMRRHRDILLGCSFTWVTDHKGLIHLLKQKNLSGRQARWLERISEFDFTIEYVPGVENVLADALSRIYAHDRPGTVRAPSEYTQFDEEGDFSTVLQSFAISAPVSVDPESLMELEKPSSPLVPPATAGGRVLRPRPPRPAAEPRVASNSQPRRKGNAPAVSSSRSEGKKDLEGESATKAAPGPGETSHEKPHPKAHPNASVTAGEATTGRPETAKEFAKRIKRVVLHGPRGEQREGVQPAEQSSGLSQQPELGEYAPVPPLTAQESQFLEFLADNTEGIDLLRALQGRYSDDKFFETILANPKQFKNFLVKNELVFLRDSKRTLLCIPNVLVDGRSVRELVIRHAHSLLAHLGSHRTLSLLRDHMWWKTMVSDVQAYCDSCMTCKRSKPSNQKPYGLLNPLAVPSKPWEAVGVDFVGPLPESRNRDGTFDKITTIIDLLTGMVHLVPSRQDYKAPEVAELMFSEMLRQCIGPNQKDWVSKLPGIEFAINLARSESTGFAPFFLNTGRLPRVMVWDAAGPEEYPGVRSFAQKVKNAVMAAHDSILAARVKQTRDANRRHHPAPFELGDLVYVSTKNMSLPKGYARKLAPRYIGPYRIVQDYGNNSFKLELPANLRKQGIHAVFHSSLLRVHQPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S994</accession>
    <name>A0A2G8S994_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S994"/>
    <dbReference type="OrthoDB" id="2752736at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="83"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="687" mass="76107" checksum="962BC4ED6E2B761D" modified="2018-01-31" version="1">MASPQHSPAPFFTTPCREMGLDALERVITQIVAEVQTLVSAVPPPRAQAGSNYAKLLYSLHGAFEQGRAIVAGLVNSTSLPIHRVPPELLTRIFALSPRVIMHGSDRDRNGGEAQLAYWPFKAEVDVSDLYRLTKVCRYWRDLAIATPTLWTTVGTGSRAHRKSDFVRHSIFLPDNPSLGLVVHLDRHKLSTRIKSMLTNAPNIQELHIWDTASIPGLSSSWRFDPSALEHCTLWTNDTSSAHQRSGTNSNLPFSFNNGGATKLRSLCLSESFFHILPPNGFPALSVLILSTSPAKSRTKMTDLFRFLAGCPQLEEAYIYNIQRDASPTSTLNSLPIIALPRLRYLSYTHSRDRKSGWKERADPIECLLSHTSIPSTCHMYFVVDDTKHRATNVSIIDSVCRHVGGKDSTTTHLFLWLSTNTSDNRSSMQLVFPEGSLRIQFKTNNDCLEVLHSFPRIFSGTEDIRIGYDSTSGYAHHDPRHSLASSLPEIFPNARAITLIPKVIPKDRSRYVVRALPLYLADPPKPTSSSAPTGGEAAASAAVPHPRLDTLWILVQSKKEIGTLKKILAARDALGFPVRCVVVHHRFAAGSTARAHLRALPVEQVILTHPKASESKKEREGDWALRFPERFSLPPAVRRDWPTMWYGNHWDSQDDDSESGDESDSSVASSGRSSSVFSSGSLSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9A3</accession>
    <name>A0A2G8S9A3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP synthase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_07519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit b, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the eukaryotic ATPase B chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9A3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9A3"/>
    <dbReference type="OrthoDB" id="67388at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008688">
        <property type="entry name" value="ATP_synth_Bsub_B/MI25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013837">
        <property type="entry name" value="ATP_synth_F0_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733:SF3">
        <property type="entry name" value="ATP SYNTHASE F(0) COMPLEX SUBUNIT B1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12733">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE B CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05405">
        <property type="entry name" value="Mt_ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161060">
        <property type="entry name" value="ATP synthase B chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0138">CF(0)</keyword>
    <keyword evidence="3 8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL30335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="242" mass="26459" checksum="4BEB03953BBBC3A9" modified="2018-01-31" version="1">MASRIAVSSLRATASRVRPQAISAVPRVLAARGMASSSKPPPEERAAEIINTLPSSPNLITKTGSVVLGTGLLATAISQELYVVNEETVIAVGFFILISFIYKAVKEPYRDWAEGHIKRVRDILYASRAEHTQVVKDRIQSVEQMKDVVSVTEGLFALSKETAQLESEAFVQRQKVALAAEVKAVLDSWVRFEQQAKESEQAELVKAVVDSVLKSLSNDKTQKDILASAVTEIEQLVKNKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9C7</accession>
    <name>A0A2G8S9C7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9C7"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="355" mass="39262" checksum="E23AD7DACAE1196C" modified="2018-01-31" version="1">MSSSEDTADVVAEFSSFLISNYCSNAATTLYMYEYLLTIDYEVELFWRRKFTGASALFFLNRYLRLWFYIAQLIFWASLSSPVRRSTCLPVVVVLIRATIPSRAFSGLRMFAISSKNWSLSIIVFALSIVPFATDLVNMRYGITGETLPDYGCSAFELTPAFIERRRAFAQALQLTIAGWTCLMGADLLLIVVTWFALPRRTLRSSPNSFAHVLLYDGTIYFVILLILNTLHLVFTTASLVTPALQNASDMIVFIEPVTAILVQCFLIHLQLANRKALHVGTSQNAGFSQDSMGTLVFERVVGSLSASLTPDDYVPVSSTDVDSAMFSKSSDASDAGEGDVDDGRGKESIPLEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9D3</accession>
    <name>A0A2G8S9D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9D3"/>
    <dbReference type="OrthoDB" id="2756573at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="178" mass="19132" checksum="2B99E15BFD04CBBC" modified="2018-01-31" version="1">MGADLLLIVVTWFALPRRTLRSSPNSFAHVLLYDGTIYFVILLILNTLHLVFTTASLVTPALQNASDMIVFVEPVTAILVQRFLIHLQLANRKALHVGTSQNAGFSQDSMGTLVFERVVGSLSASLTLDDYVSSTDVDSETFEKSLDKQSDAGEGDVDEGGGKDSIPLEPVCSEGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9T7</accession>
    <name>A0A2G8S9T7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9T7"/>
    <dbReference type="OrthoDB" id="2736021at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="99" mass="10738" checksum="66827D7EB80161EC" modified="2018-01-31" version="1">MLEGLVDEYAVGCQVDMSKLLAVGADGKLRLQVIWQGDIGEPGQNLPMFDEFGVEKVPASISEVPFGEPVHAVFSIDFVRDRRAGTRTIVASLFSLTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA91</accession>
    <name>A0A2G8SA91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA91"/>
    <dbReference type="OrthoDB" id="2859538at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="635" mass="70679" checksum="D12E7739AE2546E5" modified="2018-01-31" version="1">MDPLHNIPRLSELSEHLLRLSTTDRASLSALTSVSDIQKWTAAKADEYRQFSLALLAIHNLAAPIHRLPTEVLERVFSYCWHDRASLRLLHVCSLWRSIILGRAAFWAEAATKCGPLFDKRPVMHDDLPFVNAVLSRSACYSHGIAPFFHGFSPNIVKSLTPYIGNVVSLRVTLDRPSDLHEGLWPVLRSGVPKLNALHIELVRITDLNEDIPEWDLDEDSSNPLAILSHENLPQLSRLVCQPAMVRLFGGVPLKSMTVATGRDDPPELSEDDTSLRHLEPYRLCLERLEAIGEIFWDGERPAEMQAFQFTSLRDLRIKSRDSLICPILSWLAFPQSAYVHITNSEAFRGPPFQRLLSRTNCVALRRVVTAVDHVCIRCLSRRFGNHTLIGFASNAERFRLENFVISPEGLVEVFSTNPSITRLSLFLAERMPLEGEVDLRAFPHLVHLDMTAPDMDILVRILGSTDKLRRRPAEPKPPLCLSLANLVITCGLTVVRAAAAPPPPKSKPKGPTKTSRSTSKSDRNPGPGPTQPRAIDVDEVFERKCSILQQVLAHLASSGTRLSSLTLRLHPVTREILGRNSASGDTGSAESHPRWPSPAARQSVLEGLQRLVDGPVVLEFLDRAAVDVDWEAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAM7</accession>
    <name>A0A2G8SAM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAM7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAM7"/>
    <dbReference type="OrthoDB" id="2798231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051320">
        <property type="entry name" value="Viral_Replic_Matur_Polypro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064">
        <property type="entry name" value="POL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33064:SF37">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="171" mass="20278" checksum="D136BDD231FA8763" modified="2018-01-31" version="1">MFFGLCNVPATFQSMMNHIFTDMIREGWLIIYIDNMLIISNDLETHRIRTKQVLKRLQEHDLYLKAEKSEFEVTEVEYLGVILKPGQVLMDPVKLKAILEWQTPKTVKQVQAFLGFRNFYRRFIRDYSQVQQEPYYANKDLTTSGTLVPSYLSHSRKRNAITKFTIENYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAW6</accession>
    <name>A0A2G8SAW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAW6"/>
    <dbReference type="OrthoDB" id="2803610at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="88" mass="9255" checksum="25CCD28729FB6D10" modified="2018-01-31" version="1">MSRLQSLFKSSASTSSQASSSSSSRRSSASMMVDASPISYVQFTGLAPTPSQKPAQAQSGTSNGGGYAEMLDEDNMAWVKPKKASRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAX7</accession>
    <name>A0A2G8SAX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="12">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_07086</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAX7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAX7"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000013">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="13"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL30917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="87" mass="10090" checksum="FCB7FA17DBEB67CA" modified="2018-01-31" version="1">MSGRQQRVMVQPINVIFKNLQQKSKVVIWLYDNIEMRIEGTIIGFDEFMNVVIDDAAEVYVKDAKPRRELGRILLKGDNITLIQQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB06</accession>
    <name>A0A2G8SB06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="15">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_07115</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="15"/>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB06"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB06"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="16">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL30946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="503" mass="54505" checksum="E857E334E721C3AF" modified="2018-01-31" version="1">MSFFCSISGEPPQDPVVSSKSGHVYERRLILKYINENGTDPITGDKLEEGDLVTVKPNPKAAPPRPPNASSIPALLQTLQNEWDAAMLETFALRQQYSSLRQELSYALYAQDAAQRVVARLIKERDAAREALSSVAATMNVEVPAGGDVEMGESTEEAGGLAAEVVEQVNQTHAALSATRKKRKAPEGYATVEDVKGYTAKHTIPSLHSPSPSGINSLAVSTTNPSQFLTGGNDKIVQLYDRETDKVVQTLKGHTKKVLNVKFREHEGDNTLILSSSADKIAKAWTHDTASGEYKTAGTIRAHKGEVTGLGVHPSSKYLALGSADRTWSFHDLNTFQQVFRSPEFEDPFTTLEVHPDGHLLALGTPGGAVQVFDVRSCALAASLVPTDVSPFTVNTLSFSENGYHLVAPDSLASVAIWDLRKPKIAKSIALGESFKVNKVVYDYSANFFAVAGNEGLRVIAHKTWEELVRFEEGGEVSDVVFGAQGREIWGVSGREVRIWGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBK6</accession>
    <name>A0A2G8SBK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBK6"/>
    <dbReference type="OrthoDB" id="2758237at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="147" mass="16912" checksum="54DC7768BCE98E5E" modified="2018-01-31" version="1">MASPQSAGSHCEVLRTRPVLPPDIIAQVCEQIFAAPLHQYDLSLTRGRNGQWSNEMYFRLSLPLVSKTRWKPATRDLYKHIVLRRLQQIPYLARTLSSKDAGIDFGALVRKITLFRYIVVLPDWNISCRGLQAIFDRDTFTASEDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBL4</accession>
    <name>A0A2G8SBL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_05681</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL30988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBL4"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="32"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="320" mass="35527" checksum="096443E303B5CC25" modified="2018-01-31" version="1">MAADIPSFPLNSGYKMPSVGMGVWLGPDGGGEAAKQMCLTALQLGYRHIDTASGYANEEQVGRAIRESGVPREEIFLTTKLPNHHHHKVAESLQESLDKLGADYVDLYLMHWPQAYTDDNKMIPYGESPTYVETWRDMEKLLGTGKVRSIGVSNFSVALLEVLLKETTVVPAANQVEMHPCLPSFELKTYCDEKGIILTAYSPLGRPKEYDGKPVFLEDADVLKIAQIHGTTPAQVTLSWGIQRGTVVIPKSENPKRMRQNITVIKLTSEDMAVIDSIHQKPGMHRSLLKFHSVSLDAKIHGWTYEQLGWNMKQGGIIIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC27</accession>
    <name>A0A2G8SC27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_05999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC27"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC27"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF508">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="83"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="488" mass="54268" checksum="063BC75DC48113C2" modified="2018-01-31" version="1">MKLKRRGAMGAKKLFAKRSVSTPAHYYHLPPSCARCIRTPPTSHSPTTTTKTPYMRAMGDIIDFAGFDQPEHWTPHLQEVFDIDTFETIAESAAAYVTRANFREPSRGSVVAIKSGSVDPRFSAEPHDIGKELRIMRGLSHVNIIEILGHAFEQPNSTVHFWMTFLPHQVSAIISSPRFSVYSPPGATNGLATPDPSSFLIVAKSLVYQTLSALAYIHNRGIAHRDIKPNNLLLTADGCVKLIDFGVAWTEETDKRDLWPQRRGHMCFDVATGPYRAPELLFGARDYDACAIDLWSMGAILAEFFTPLRLRKCYFDEEDWCEDEDDSDSDSDSPPGKPPFVLSKGLSPNAPGVEWVRDSLYDSTRGQIGLAWSIFKVHGTPNVETWPTFKQLPDAQKVTFVEVPPVDLAGLLPNLPPIQTGREREDALDLVKKLLTYEPEWRLRAADAVEHPFFKDGAPLLLPQCVKDDAGDGHSLANVISHYLSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCL4</accession>
    <name>A0A2G8SCL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06218</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCL4"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000001">
        <property type="entry name" value="50S ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="298" mass="32816" checksum="249E191D187CF0A1" modified="2018-01-31" version="1">MSLSFLRLAAGCRQCNGAAHLLRQTPQRPFHYSAAVLARREKKLPTLSKKQLAAKERKRAKKAPKNIYDSEKMTLADAVEVLRAVEVASPNATYELVVKTEMGKGSTIPKGRFNLPRQTKEQSKDRILVFAEGRQAEEAKKAGADIVGGLELVEGIISGRYQATMFLCSRSLIRPITPRLGRVLGPRGLMPSERRGTVTDDISGYIRRLKGTSEWKGDKEGTIRQPIAKASFPAMNFPVTDVIKNVKYFLGVVKRATGNARDPQAESNKKEASQKSVNAITRVLLSTQQGPSIQISDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDN4</accession>
    <name>A0A2G8SDN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDN4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDN4"/>
    <dbReference type="OrthoDB" id="5440at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF3">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43700" checksum="1B34FCC7ED3B8083" modified="2018-01-31" version="1">MSRTFRNTVQSLKKPATLVLLISDGQESWGQQLSEEGYDVVLVTYPTSTECLAAGFAEARTTLGTDTEWALLTYGLQSTDLTVAGAIVTSGKLKACVHFCPQVENGKGLIYEDVCATTIPTTFHLSAKQEILYASLLDIAEQRSLGLHTSKPPPVSIFTYPLVTVSPPFPFEAGPPIDHASGKVKTIAPYLRSANNLSYTRTLTLLRRELGPHFPLEKLWERHTYFEFEERDAMKTMATMVSTPYVNHIATMTGGVGFQDLARFYKYHFVRENVTPPDTEMITVSRTIGTDRIIDEMIFKCTHTTEIDYFLPGIKPTGKPLEIALVGVVAFRGDKLTFEHIYWDQASVLVQLGLLDPKGLPVAGAEVAHKVVDPFGVPSNALLTRWKESQGLPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEE2</accession>
    <name>A0A2G8SEE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEE2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEE2"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7562" checksum="E731676ACED8E56F" modified="2018-01-31" version="1">MDASKAPVKLATVTKVLGRTGSRGGVTQVRVEFMDDPSRSIIRNVKGPVREKDILALLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEK0</accession>
    <name>A0A2G8SEK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DyP dimeric alpha+beta barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEK0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEK0"/>
    <dbReference type="OrthoDB" id="3207336at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049509">
        <property type="entry name" value="DyP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF4">
        <property type="entry name" value="DEFERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21105">
        <property type="entry name" value="DyP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DyP dimeric alpha+beta barrel" evidence="9">
        <location>
            <begin position="30"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="505" mass="54785" checksum="A0EEF0EC18934F2F" modified="2018-01-31" version="1">MLFLPDPGSFFVDCTSPIMASTLPPLNPANVQGDILVGLPKKVQHYLFFQIDDDVTAFRKRLRLLIPLITTTVQVQDDRAKIVANKKKAAELGKAPELLRLSGVNIAFSQFGLNKLGIKDNLGDTAFATGQQKDSQGLGDAGAPDANNNFVPNWINAFKNQIHGVVIISGDCDLTVTATQAAVLAIFNIGAHITLHEVITVKGVVRPGAEKGHEHFGFLDGISQPAVKDFDTKPNPGQETVSQGVILCGREGDVVAGTTTPFTRPAWALDGSFLALRYLFQLVPEFDNFLKASADPTKGFTSDLLGARLVGRWKSGAPVDVFPLADNPAAGKDPLQNNNFRYDFPNDFDTQDRCPFAGHTRKTNPRNDLEQLGFSTENRRIIRRGVQFGPELTPEEVSSGKTHHGRGLIFAAYCGSITNSFQFIQQSWANNQGFPIQKPVSPGFDAIIGQNNQGPDDNGPRSMSGANPNNQTATLSLPIEWVVPKGGEYFFSPSIPALRDTFSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEZ4</accession>
    <name>A0A2G8SEZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEZ4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="13474" checksum="BD29A47572B8B372" modified="2018-01-31" version="1">MFLAQGFYARRLYIVNRKYRLVVFLAVALLLLELGFSIVGTVVGFKGRSFKTLAHYSWIYATVFGLAILVDLILTGAFIAIIRQSRTEPLGTSPALVVLARYAVFASKHVPRFPDFESTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFC7</accession>
    <name>A0A2G8SFC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFC7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFC7"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="108"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="399" mass="43938" checksum="AD21F2E750C30EDE" modified="2018-01-31" version="1">MADVTVAPNKIAMSRALGAAFLNHQVEQLEKSVHTAGNWRERRSPDNWRAGAGDNKRNFAGPKVIQRRREDSVEGRPRQPSPKMEREHERRDRRSEEGRGPQKDADIVVVDASVLIHGIYHLKKWSRDGREEVVIVPLEALNTLDLLKKGTSALAQRARAASRILEAQVGTNPRIRVQRDDAFVLWDDIPFEEHTATAPEWVRRTICCARWELEHVSEELEKDPSPTAKPRVVLAVVSPPADAQAEATNAAPISASPVPLPAPQPNRYESRLSAPLVSRWAAKAGVDVIEVTSAPPHPHPHAGNSNGNADNVNGNKGRRSTDGGRRSNEEERGTKRAPAGRGRRNSRGGSHPGQPRAPQNMAAGTGLVERPQAVMTMMEMVTQPNRVVRVLARGEKLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFQ9</accession>
    <name>A0A2G8SFQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFQ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFQ9"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052356">
        <property type="entry name" value="Thiol_S-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036:SF1">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45036">
        <property type="entry name" value="METHYLTRANSFERASE LIKE 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29072" checksum="9C9F01C14F889EAA" modified="2018-01-31" version="1">MRLAAAFEHFVFLKIAVSAALVPTLIAILKNPLLIFRPYEVSHIFMGHAWTRLGDETDRDSRPVKEGLLPGNCSGVVLDVGAGRGHSTLYLDPAKVTKYVALEPNVLMHAQIRASAAKMGFTEDAGTFLILPYGAEKASLVVSALGGAHAVDTLMFMQSLCSVPDPEATLRALVDEVLRPGGTMVFYEHVLSPRADVAWWQRFWAPMWMFVMDGCRMDRPTHLWIERMDVWAEGSVWGKADEPEEFLFWHRVGRYVKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFT6</accession>
    <name>A0A2G8SFT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFT6"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="551" mass="59671" checksum="C3AEC7712C137A4E" modified="2018-01-31" version="1">MSRLLKRLEVGRKNEDEGPVTAWINRDIIPLPPSRRTWGAWSFVGFWLLTGFNISGWTTASSLLGLGLNVWQAMVSVIVGQLIVGFAVVANGFVGAEWHVGFPVYNRFVWGVFGSFFPLLMRILLSLVWYGVQLVFGGKSVKVVIGSIWPSFYRLRNTLPSDAGIETNDLIGILIFAVISIPLMIVPPEYYRKPFLFGSIIMTVTTFAIFVWALVKEGGGGPLLTHPSQLSGVQPLTGSAQLGWAMAYGISSTIGSISAGILNQSDYTRFAAYPKAQILSQLIVVPLSSVIIALFGVIVTSCAAGFFPDDGLLWAPYDLLEVVQLRGGPGARAACFFAGCVFVLSQFGINVAGNAISGGIDLAGLFPKYLNIRRGALITAALGIAICPWKLLTGTSIFLTVMSSFSVFLGPLTGIMVSDYLVVRRSRLRLSHLYMPNPDSMYYFTYGINFRALVAWTLGVWPLTPGFVAAVSPNSINVSIGWTRCYDLAWPLGFVLSASVHVLLSRLFPPTSLGQTDLEDVFGTFTEKVGPLQDTTSLPSDSDSKSEKGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFY9</accession>
    <name>A0A2G8SFY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Uricase</fullName>
            <ecNumber evidence="7 10">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_05383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 10">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 10">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="7 10"/>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFY9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFY9"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000241">
        <property type="entry name" value="Urate_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4 7 10" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>5-hydroxyisourate</name>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>urate</name>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000241-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL32679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="325" mass="35955" checksum="205D9DA1F7437CE9" modified="2018-01-31" version="1">MSELSYLSHARYGKDKVRVLRVVRDGAWHNIVEYNVTALVEGDIDVSYTKADNSVVVATDSIKNITYYIAKTSPHVLVPERFALHLGTHLVSKYAHLKKAFITVEQLRWQRIPISQGPGQTPKEHSHAFYRDGDEKRTVEVEVDASAGKDKLVARVTSGLKDLLVIKTTGSAFESFFRDEYTTLVEVNDRIFSTSIDLTYTFAPISIPKPADGEGKVFEAPFAGDAAKGTPWDGDALAAALRNITLEVFALDESASVQATLYKMGQRIIAENQHITTVTYSLPNKHYVPVDMKYIGVDNTTPKNAEVFLPLAHPSGLITATVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGL3</accession>
    <name>A0A2G8SGL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGL3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGL3"/>
    <dbReference type="OrthoDB" id="2746915at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33752" checksum="4C56DF3E66CD26A5" modified="2018-01-31" version="1">MDKETSEDLGFLQAASLHYPFPSLQLLSLMVPSLTPCVKLIQMMRTCRLTRTTAVFHLTDRVFPSEISDVFTALYEHCSLATLQVVEIRRRNNRDWDLSDEDAFHLDHLQPLLRFPGMRSFTISTPLIVDMANDDLRAIADAWPLLVTLLLMDDWGFVNLPEVTWAGVAYLLWKCPQLMILSLSLDSRIDDVALTTSLPSFRPNMRLRFVSVTDSVLDDAEVFAHSLFAIAPLVIGIDGWGHKNELLEISVPMANSFAFLDQVELLLWELRRTRMRDHFAFLDAYGEFFVIVYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHD2</accession>
    <name>A0A2G8SHD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_05096</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHD2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHD2"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17934">
        <property type="entry name" value="DEXXQc_Upf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13604">
        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="566"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL32978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="785" mass="86525" checksum="1BB9A0C5D908E400" modified="2018-01-31" version="1">MPTFTQKVVPGLPADVPVQRLKADSCLALLERLGLSSFTGTGDPILLAISFRLTKGGFIEAIALAADTTVFQVTVTKNTSHSDLASVLTHPRCLFVAFDMARVALLLHRQFGVHIRGVDLTALAPEPDPGSTRQHPAVTLAQDLLPRPVYNQGICALFYRSTNKDLCLRAWLSARIASECTREIQREPKVDTRHLTGPQLACLSQLVLNVELLDAERPTRVENDFDAIKVTDKCSVTLRNARFKSKVRKSGQTIVHINGGKVKALAIGVEGKQTTLKLLGKSELPDNVKKVCVVGREDPTNAELARDKFVLRVMQGVEAMDESPFVKMLWFPPPSQGKGKGGHRKKKAKAVEEDVQITSPLFQKLNRSQQAVVKAMIGKAELFVIGHGPPGTGKTSTIAVGLDHWAKTRGRAWVIAHSNVGVKNIAESLVKRKIDFKIIVSKDFYYEWHEHHYVDISDHLIQSDKLSHKNTNLDALFGKQMIVLCTLSMLSHPSEAMNRVFQLVPVERLIVDEASQIDTFEFMHIFHRFSKSLSKVCMFGDPNQLPPYGKETAPKMKTIFDFAQFRASSYFLDTQYRMPVPLGDFISKHVYDSRLKSSHAITSAACVMFVDVRKGAEAPAGSSWKNMEEVHTVVNLVKRYYKDERKVCIITPYDGQRAALVSALKTAGLPHGNVYNVDSYQGHEAPLVIVSVVRTSAPGFLKSLNRMNVMLTRCQTGMVVVTNRAFLCGPAQKTLLGKLADHWGTLPAGAQTTGSRSRCGADCSDAVWVDAMRVAEGTARLPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHK4</accession>
    <name>A0A2G8SHK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHK4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHK4"/>
    <dbReference type="OrthoDB" id="3218262at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="696" mass="74218" checksum="D0ADD24DB262B66D" modified="2018-01-31" version="1">MEARSSSYSTVSAPEISLNELVSRRHANFITLPEELCPTSRPSSPTSSGRILATRNYISGLVNLAGGDPANPKWGNVSRFAHLACTSRGYVPMETGVRIGDGRQVSVGKGFKWELPETEQEWAAYERRWEEAVAEETRKRAKEAAKANDGAKASKTSKYFKPSAEPDPPPRPSSKAEVIREKVERWQAQVVSVVAVQDVPTSQEMTESPLKVIAEKVQVKAKGGKVQASLGFPVVKRASTSSGKGGSSASSKPKLSPTTRVSTPPSDEPMPSAPKEVPEPMARDIPAPPQETSEQAVVAQITEVPELSFLPPSFPSQLQTSTPPLNDKRRKPQPIAPCSPPPTSPLSATSFDAAKPKPQDAQQASSSQSLVSPIRKPQKRGRNGSESTDDDRMDISQSPAATRSPLAKKARTDKLAQAAVREPASSGSAPAPPSTLPLVSSLPTAPVTPVSRHKGLGNAKGIPVPSTPNSNPLPNLTDLLATSRRSKPRPRPPSRKSTPHSRARSRESDEAIDRDTDLPAVDEDDEDRGREPSPTKTYFSSPASGSSGSPGSVAQRPASPVSPLGFTQHPSAFAPRFVSSQRLPPLPLDGEDPFLVPPHAPARGKTSTPQLQAQGQNDGGLMRGSSGFFGMGYSSQFDVEGHVEQVSEILGHDVDFDGWLRDPDEDEPGHDQDQDQDMSVAAQGASQDACTVGADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI41</accession>
    <name>A0A2G8SI41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI41"/>
    <dbReference type="OrthoDB" id="2765458at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="293" mass="33028" checksum="5A9AEF0999986321" modified="2018-01-31" version="1">MASSVPRQIQSAVRRQRSDSPSARNDGRTTERITVRTVAKSKRRLQTKPAKRPVRAKKAAAEKHKDAAVAGPPSTVPFQQIVVGEREGEPNYRNPGQPSSQAENRQQGDDAPREHPSALADAQQPGPSTDANHRNVVEEPPFRVVPGPLPEGVPRPSIARLQEILFAIDDICEYDGHIQSEVADIENLIMEIRHREAEVARKVRNVQRTRITVEKLYASRVRVDPWLIGQGKRRSESERESEREREREEQPEVAEDQLRRKRIANGKRRADDSAASLADDEEARPRAKRGRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI58</accession>
    <name>A0A2G8SI58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI58"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI58"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="134"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="418" mass="44302" checksum="81073A4BECE02655" modified="2018-01-31" version="1">MAHGPALEPRRTQPAIFLPRLGIGICLYLSSPPSPFPTSLPFVPPASAPSSSPRDTLPMAAVSGPSTARHPSPLKRHTRMSSRPSGSSSSHVVDPYYGHEETAKLCARFVTHLFACPDLPPLSTAIPPAPSPPLANFIAYALHRTRLHSSVTFAALYLLQRLKARFPAARGSSGHRLFISAFMIASKVICDDTYSNKSWSIVGQGMFALREINQMEREMCSYLEWQLNIEPNALKEFEAKVRRDFKGLGPYPTYVLPSPAPSPMPSTTPYNAQTGGAAPTPSFAARSQQPPSTSPPKPIPPPVPVHAGAPPYSASSSPHTPGTPDTPESSMSTSTSPASSVSPSTPLGYEDHSVRVVSSGTIGTPITIDSQSPTTASHMPGTSSSSASVAYAAARNVPSVLKKAKCGDIFARASPCVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIZ6</accession>
    <name>A0A2G8SIZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_04369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIZ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIZ6"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43117:SF4">
        <property type="entry name" value="OSMOPROTECTANT IMPORT ATP-BINDING PROTEIN OSMV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="28"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="332"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="592" mass="65465" checksum="03DAE4E30ECB952B" modified="2018-01-31" version="1">MQWPNPLKRLPRLPPIRLLSNNVSGSGLPVINIPKSSIYELGSQEPTLHDVFLIVHPNESWAVVGADGAAGKTALFGALTGTHRVTPPAPPPGGLFPFLEDADPHRYVHMVRFAHRGTSSGDEFYDFTARYGAVREGDRQTLRETFFPDMARPAHPLAIPALHENAKMGLETEEGLRARERRQSWFDFLAGRLRLTNLLDLPMVALSNGQTRRARIAKAFLEDPRLLLLDEPLTGLDAKSRAILLALLEELKKKPATPHVIIGLREQDPLPDWTTHVALIEDGGKVHTGRKEDVYPTLFTPAAPLVSASPSPDSLAPQSPSYKERTKGTPLVDMAGVTVEYGPRKVLASVRWTVHANSRWHLIGENGAGKTTLLALLTGEHPQSYTQSDNLRLFDRPRGEWATPLLHRRIGRVSPELFNAYPRRANLTVWDAIGTGFDGGFVPMGVKRVGMAEDGTPLVGGSQEEEWRVARMHEVMRNLGPSQWHTHPDTLTDERFLRKPFAGLSPGEQSMVLLMRALVGAPSLVLLDEAWAGMDKAMVQAAHRYLRDGGGGLTEDQACIVVSHWEEEVPWSHEDGVERFRLDGGEGTQIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJT0</accession>
    <name>A0A2G8SJT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJT0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJT0"/>
    <dbReference type="OrthoDB" id="2756672at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="444" mass="48694" checksum="1F25DA9201AC7611" modified="2018-01-31" version="1">MAAASEITDLILPFLHPPMIFGGDTSNLKAMTLGPDAPFIPGNSFPSLVNLKLRGMGRGVHATTSTLMDLLSNCPRLETFEVHFPLRDLANNDQQSNNRPPLPLNYLKALWMSHTSVTSAFGLLAQLELPAITTVRLTNLATNRSRAPIPRNLVLPLAHMGLTQLDILEGGKHSGPETPFGLHFIAHGPGPDGPTATTKTARTGLLVHVSFLRTRDRALAEQYTHEQGVFWDVLRALPTRAVTALRMSALRAAHLKRVALIVGDDRAESAMPLESVVVRSVKAGSATEQREAVAYLARVLLPYDYELEADADGWGGSASTSRREADAPVAVAVAAAAPRLRELTIELNRAWKPGMGDLLVTALRERKARGYPLRSVACSALSVRDTELEGRMREHVVGDVKVTTRKLWEIRKVPEVWMVKNDYWRLYPESLARTVNGWGLPENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK54</accession>
    <name>A0A2G8SK54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK54"/>
    <dbReference type="OrthoDB" id="3164380at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="229" mass="25244" checksum="1A73681F08ED4367" modified="2018-01-31" version="1">MSDDSDILSHFTPLDELIQVVYQGSARFVILSSVDDAAWTLHVGLTGNEGRWWRGRWTDKDVRNTVGQKVSSILLESFVEKMANAFVQGNVTVGDWSPTRGAEIQLILGTTAKTPIRIPLNELSSEDAAAYAIKVFTEAKEKVRDLPKAGSGKKRKADLEEAEEKIEALKAELEKTKRRQGAIMTEPSKLLPKSNNGSSAPSRPKGASLANPTKKARKYQALEFESDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK88</accession>
    <name>A0A2G8SK88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK88"/>
    <dbReference type="OrthoDB" id="2744308at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="38073" checksum="6A90DE288AEDA11D" modified="2018-01-31" version="1">MHSCKKAEALAEQGNINKSVTASHMKPSNVSLEDMSAEYVVLCFLSYYYCKLPGRHSTSAPEPPLLFSHMDADSDAHIASVLLSVILEGVFFLLFVVTYIFGSWVIICGVPPGRLKRPSTALFIAGTAMFVLAGVVGCHSTRIAAASMLTLGVHQHFALDLHIMVSVSPMDIENHIIPSWYDPVHKAKFVIYVTQTLIADGFMVRTILNHEERMIHCNASTDISAVVEGMIQSAFLYSAASVVLVVTIFASAHVAYVACLNVFPALSGLVFSFIVIRVGLQSTEAQYLPVSQMQESHLPATSIPGSPSRRHGGSREHQPPPLGMRNPDETDNDVPSKDKFVLTMPSPSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLF6</accession>
    <name>A0A2G8SLF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLF6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLF6"/>
    <dbReference type="OrthoDB" id="3363836at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="517" mass="54985" checksum="50A82769D1326129" modified="2018-01-31" version="1">MKSGFKTIRLGHAVGIHQHAAQHSKRDSCSTGGLYKTPTKGQTVDASQPVAISWDTSCLNTTAIDIYLYAPSAARPVIHEWENVDYKTGSYSATLKPGWWNSTSSVNLEFTIVPAGQPLFAVTIPAGPIFTATYSGTSTDSSAAVAGAVEQVNNTPTEKRGLSKGAVAAAVLIPLLLVIGLVSAAYIRISRRKGKEKRKQFSEMMDKRMSTISADWKSLSGAGANAAIRNSMAFPGNRASSFSFGGIRPSSTVAVEGGQAGIGAQGRMVQDTASSGAPHMSQLRPGVRTSAFENRVSRVSFAADPRPSSESRRTRQSRAFHVGHGPVPPLPDRQYSSEGSSNGSPILSPIQTDGPLTLTSEDIRARMSGRDFEPRPSIDEVMPALTMMHVGGVEGEKDELLFDTPMPTPPSPTHQVPKSPIMGVMPMQPMHANVMSPDAMLRAYAERHAMGAATPGIPAVPAPAANYNNMGMRVLYSPDTTAPSSIYPTAAANQRKSLASTEYSKYDEEDAYVGTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLG8</accession>
    <name>A0A2G8SLG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03383</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLG8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLG8"/>
    <dbReference type="OrthoDB" id="109543at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23802">
        <property type="entry name" value="UBCc_UBE2Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051838">
        <property type="entry name" value="ARTD_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21328">
        <property type="entry name" value="POLY ADP-RIBOSE POLYMERASE FAMILY, MEMBER PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="894"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119624" checksum="D9F754D3249BB470" modified="2018-01-31" version="1">MEMSPSNIPTRGRKRFLFDLRNASQKAEQGVEVQGFRILSVVSGDEDGSFDCAIAHADGDLIASLTVLVSDASEYPSDHSFFCSSQDELPAHILRVTESIYEDGSLTIQQLLTRLLEKLARRTAAATHDDDEEEGEEDDDDDDGVVDYELDDDVGMFGAEAGRSRVDQTVLQREFNEVVAYGFHPGYIPFGIDDFALSVSLPARFLANTIPPRALMAWDKQLLSRPQHLTLLISGLRGVYPVVQSDATYTHAAHVHGSTPQFRVGLTPKYKPTTDEAAETIRRYGLKEEYDALPADVVEEPSFEDLEDDDMMDLDGNEPQPEVVEPQEEEPLSGFQPFSLSSSLESLLNGHFLRILQLRIQYGLGWAAAETLCWEVETSQQPPGDIIRLRGQGIQSADAADTLLAQSYVLPPDPLLERNREDPINLPLLAFSYLLRRITLCPRYCLVCHQQLQEDLDALKPYVCSSKLCTYQYYNLNRGPSLEYEIRANPTIVDLLISLAYIAAAESAGADSPLPIGMGLRVKGRSNFSVPPGPDGLCEFDQLPANEMRSAMVQLIDSLPPIAEMKKHLEQPRAAGRAKPRLQDIDKTIPHAAWSVLRWIVASCTAHLEELTDDEGRVKNIGPEWRQFRFSVGAPDAEAKFRVAVQGAQGENAKARQYPSLYAFHGSPAKNWHSIIRHGLWFKTIVHGRAYGNGVYFARDGAVSTGSYAAGAQSCWRNSATRINNCVALAEIVNLPSKFVSTSPYLVVAQTDWIICRYFMVKGSGSGQWAPGPTYVSPLFGLPNNQPTQAEEIDESIPYVPLDPQYPLTLSGRAIRIPEPSHALEKILVARREEYIPVDYDVEDMKIFEAAPVVPTAPDVEDMMEVVDDWKHDRTWVEQCVEHVIPPPTESSLQATTALQRELKGILREQKEAKSLRELGWYMPEDLIGDNLYQWIVELHSFDPTLPVAQDMARHGVNSLVFEIRFPAGFPHAPPFFRILKPRFLGFSQGGGGHVTLGGSMCMDLLTADGWLPSYSISAILIQIKLAISNLDPKPARLASNWDMPYGMQEALEGYRRAAATHGWKVPRGMDRIAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLK6</accession>
    <name>A0A2G8SLK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLK6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLK6"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="279"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="546" mass="57227" checksum="771FCD7707AE5E75" modified="2018-01-31" version="1">MSRSAADATSSAPSNPPDDRRRHKTPRRSSSTSPSRHTLPTHPHAVPGASSSSNIVSQDPPTTSSSRVPTPSAPAPASDPESSHRRRKRERSSPSGSSSQGDMADTEMEGGPSKPSTSESAPEGAPPKKKRTRTLTTPHQAAVLHALLAQSRFPTTQMREEVGRSIGLSARKVQNQRQKARRPRGQATTTSAPLTRPPQFGPFTNAPPGGAASDISPTAMTMHSGSSASADGFFPRGLGGMSEMPYGTAGPSSRGPLERFAPAHRDAYFPEEYGRVGAPSAQLAGPGIPGSSRRGLLDDPAWRRPAQGFPGPPSASASASAMEPPEMYRATARPGRPPGEQGPALTLSLPPVLATRIDTRRGGPGSSPVTPLSASAGAGPYPTLASLSALESSASAHRTRASDEMRRTFPPANVDFSGPRGPPLNIPPPFTLQPRPLWDDPAFSPYNRGRRSSPPTPSFGESPTALHSPFGVEPLPSISAVVPLPVPVPMAAPAGPSPGARRQTLSTTSTTTLHDPDPDPDPTTTQTNDHHNHHRQHPVIFNIAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM40</accession>
    <name>A0A2G8SM40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM40"/>
    <dbReference type="OrthoDB" id="3060996at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="70810" checksum="254871DDAB277709" modified="2018-01-31" version="1">MLREERPALKGAVRVLMLQSGALPASQDKKPVTFIALPEDVLQPIFAFAAAELEPTDQFDPFIFSSGAHHPWLRLLRTKKGFPLICRATFWPGTTALSSDIALRRMGQVVALADTLRSADIGPRHGTLIKSIRWDSCVVAAPCADAIREEMAFILGQCTRLQSFSYHPHHQFPLRCQTPWPDRDECEGSFNALWFFTTSTSLSDLLLVQPVAVCSLRSLDISVDLQKVDIDNRVDVGPMLMGIHRILSALKGLESLTLGPWSSNSLIPEALMTMPSISLPSLTELQIFAPPREDVDAYLCSRWDAPKLTRLTILISTEWAGSPIGLLQRLGSRLRYLHFYPVTLYPRVWQHISTLASTLATVCPLLEHLIVPRTCTAFVINSPTLDLWTSMGGYDLKARQDKARADTYREWAVDAVQSNSNVPALRTVRFLFMFMDPLVSPLGYEEDEDGVLYHRFPLGRVVQTVAAIIPESYWQMRRGTEEDEESEWESESESEEWEAGDEEDGDAETAGSDWTSDGSESEEGGDSGSHPDENGVAVIEENVDGANGPRALKDGSTHHADLPGEREQSRDREREEDGGEEGGVRLDRRQLEAAAERALRVEYPVERLDRATILAAFRCGIDQAGYDQADLRDHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMT2</accession>
    <name>A0A2G8SMT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMT2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMT2"/>
    <dbReference type="OrthoDB" id="2749745at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="539" mass="60114" checksum="A8981E41F38CB31B" modified="2018-01-31" version="1">MKRRPRKPSHPGLKSRRPTLEFPHLPSFSPLKRARSTIPRSPSSPPSLAVYLQLVLLVSLIPHPSLTMPPALQKTRGPAQQSATIKTSKAKTAAQQAAEVAAAMAKKRSIENTAADDVALKRRRALAASGAPPPPDPDNDPHGGATEEDDDPDRVKPKDPVWAAAMWRLDATASETSRFNLGIKKPYRQMRGLSRELSEYLDHTQILTYGVNFHFKDVAERPGCTSLECNDDVVAEAVWPQFLKYMPELEAHLDYLADNPALIAIIGTYMSAIAMKVRSDDLGRLNDRIITLCNIEDDKQILIVKDNRGWQDTRTGRLLCPLRYLPKFEADPARFCTHVRNRLVRIFSTDYPSFLYDMSLVNQSDAKLGLLRGPALVNCYKSIMTGKSSVYNATGRAPRGQKSVATSYQIETVNLHNIIYVSLLARSALSDQEWTDVYGKFWKAENVVFSIMEIAFNFPEWHADLIQWWNRQVFGDDSELDSDAERDMMGSAFYTIMAQKDRASTTPDDNDNDNDNDNDNDDNEGSASGPSGAIQGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNC9</accession>
    <name>A0A2G8SNC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNC9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="212" mass="22765" checksum="6C9A4DF953E68364" modified="2018-01-31" version="1">MAERELPRADDEARPAVRDDPGCDGREGEPIAHQCAQDAAAPADGDRDDRPENRSAESRRQSGLDDLLRLLWQVDDGDRRRAGMPSRDGLVSCPLARMAGDQACEVAGERERRPRVHGDELRAGLAVELEEARRVVVAAREEAVPEARVRELAVLLCDLVGAGGVVPPAPAAVGDEVDGRHARDGALAAEETGDTGGVERELCIGEWLRDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP29</accession>
    <name>A0A2G8SP29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">COQ4</name>
        <name evidence="8" type="ORF">GSI_02230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the COQ4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP29"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP29"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00081568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="296" mass="33438" checksum="A4AF1B27C8EDD086" modified="2018-01-31" version="1">MSLLYAPLRVSRCTARSLRLAILPSMNAALPPHPPWRTRSASTKPAYEGHVPLNCFEHGFMTLGSAFMALANPRRGDMVAALGDLTSGPVLPRLRDRMLASAEGRQILKERPRVNSDTVDMNKLALLPEGTFGNAYVTWLERCGVTPDTREPVHYVDDPELAYVMQRYRECHDFYHCIVNMPVNVEAELAVKFFEFANLGLPMTGLAAAFGHLRLTQTKRQKLFRDFVPWAVKCGSSAQSLITVYWENRWEQNIDELRRELGIWESPVEPRWGRPLSEARAAAEKRAKEALEQASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPD0</accession>
    <name>A0A2G8SPD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPD0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPD0"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="269" mass="28960" checksum="E952FC24AB9903CE" modified="2018-01-31" version="1">MSFASPVKASLNRIAFITGGAQGIGRAIATRLARDGYDIAIADIPQAQTKVDGVIDEIKSYGRQAISLHADVREPTQIESAIAQTVEQLGPRLFVSVANAGVTQVRPLLECTPEFIENEVRINLLGLMNTHIFAAKQMVKQGFGGRIIGAGSIASYRTAENLGPYGGTKFAVRGFTEVAAKEWAQYDIRVNAYGPGIVDTPMWDHIDRELAKIEGISVGEAKAVRVKRDIKLGRIQEPEDVAKLVSFLVSDEGEYITGQTIKSCGGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPD3</accession>
    <name>A0A2G8SPD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPD3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPD3"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="234" mass="24995" checksum="56B9F5ED984CB8FF" modified="2018-01-31" version="1">MAVSSVHNAALNKQFGLVRSLVSQDHKLVEAVDDDGRTPLHWAASSGSVDIVRYLIDEKADVNLGDSGGWTPLHIASSGGFDVVVRELLGAGAEVNRTNDKGITPLHYAASKSRVEIGKLLIARGADINARDRANQTPLHRAATTGSTGFISLLLKPPEGSPKTRLNPADRVGNTPLHLAMESAHAEAACLLILAGADRERENLDGEMPEDLEGVGGQEQRRAKAYVIERCGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPK5</accession>
    <name>A0A2G8SPK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_02383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPK5"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="226" mass="24821" checksum="0853E2C99F3AE552" modified="2018-01-31" version="1">MSHSAFFYGTLLHPSILRRVIGHEGSGLEICPALLQARAHPSQDKNYPAVLPHERSRELFAEAGHEEPPADQRNVRGTLVTGLNDKDIALLDLFEGDEYTRESVLVHPLGPFTALSSTPVPRTTTPSVGAASIPLSQSTTNAYLVPLTAPELPPLDLLPPPLPAQTYIYAGPLSDLSPELWSYEDFVRENAWKWVGRGTVDDNYAEVDRRREMNGSTLKTEVAADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPS0</accession>
    <name>A0A2G8SPS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_02443</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPS0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPS0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000061">
        <property type="entry name" value="ATP-binding cassette transporter YOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="207"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="551"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="650" mass="72140" checksum="E127791C323CEB0C" modified="2018-01-31" version="1">MADEKLSRVDSTDTDVEKGHDVDVALKEAQKTDLSSRKFDFDTGEEHVRFRHHWWQIWLPKDPPPPPPASLDDAAVIPLVTSSIFAILSYAWINPIMTLGYQRTLQATDLWKMDYSRQSGNIGAQLDEAWARRVQAAKEWNFRLENGEIRPGIFKRAKWSAQALRGKGTYGDRRTALEEHWRQVDGRKEASLAWSLNDVFGREFWSGGAFKVIGDTSQLMGPLLVKAIINFGKEHAAAATESRTPPSVGRGVGMAIGLFCTTVTASVCQHQFFWRSMTTGLLARAALTSSIYKRGVSLTGKARTTLPNATLVTHISTDVSRVDACAQWFHAVWTAPIQVTICLIILLVQLGPSALAGFALFLIIIPLQERVMSFQFRTGKKSLQWTDKRAKIILEVLGAMRIVKYFCYEQPFLKRIFEVRQNELKGTRKIQIARSANIAAAFSVPVLAATISFVTYTATAHDFDVAIIFASLSLFQLLRQPLMFLPRSLSATTDAQNALVRLKKVFHAETRTSEDTFSVDENQKFAVDVKNATFEWEESKDVADLLSVPKKGGEKRAEKSKDKEKASTSPTPNVSAPFQVKDVTITIPRGTLVAVVGSVGSGKSSLLQGLIGEMRKVSGEVSFGGQVAYCCQTAWIQNATLRENILFGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPW3</accession>
    <name>A0A2G8SPW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPW3"/>
    <dbReference type="OrthoDB" id="3256438at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="244" mass="27130" checksum="ABA19D4DB07A2F22" modified="2018-01-31" version="1">MLHPLSVSVSASSLPRIFYMSCALLSPSTDSLSFVPRKRTMSFSTPTACKAARTPLRRTGSYLSLADMQAPDYAPLYGRDGPTKNYTGVESLVVGHYDARMRKRRTPPCRAPVVHATPISSQSHSSPAPHIHLSSSRRTPSRPRCSSPLAPVQRPMPERPSLPSNKKREPDLYRTAIETRMRLSPVGRNILNMGPRIAMSIFTATEALESLVAAQRDWDMPDVAVEASWVEVCHDDWEMVERDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQC7</accession>
    <name>A0A2G8SQC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQC7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQC7"/>
    <dbReference type="OrthoDB" id="2322499at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="641" mass="74195" checksum="7DDDA04CC774F73C" modified="2018-01-31" version="1">MPEMPLDILFEIFAFLHPRDLLNLARATREFRALLMSRQSARFWREARQQVEGLPDLPSYLSEPEYANLLFFPHCHNCLKPNVHNVLWTFSARYCDGCQVTMFMDQKDVSTLLVEVFDHASFLYVNSKYNSGRFSGLRYHKPEIDEIKRKWATLRDDEEKRRFREERKTFITECQQFSREASEWQTGCKIQRSQEGHKLKVERFEAVKQKLREEGFGEVLDHLRLADLFRLKKLGSVNRPSKLTDKGWKSIRSSVIQHMVPLREKYCQELKQQATQARIRYLRKTLDARQSNGVPRTAESDREPGFFELAMMPAFQTLLRDESTDVRDEAIAAQLDLPGLIETWTNYYKSVFVELTLLGLGESSTTLDLVNLLDLAIVHFRCTRCKRRQLRWPHVLSHRCFRDTSASLMRYVSVDPSFVGYTRFNHDAPYRGEELARFDDHLEVARDIIRLAGLAPDSATYADMQAVGTRFLCRGCPISTKKTAYDWQAAIQHSTIIHSTDGVDPGPVWEPLPSNQAAVVQDFEWRLLARNSQLSELEKNPLNVFGCAQCPWHGDILSMKAHLHFAHPLWAENHSWSEGLYLHEDSKPCGMPTVWMYPSEAPRPDDVWEGFTLRGNTDRGKTEVGFNINQTASTYLYGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR43</accession>
    <name>A0A2G8SR43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR43"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR43"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="365"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="758" mass="82941" checksum="C9AA0728B987B01E" modified="2018-01-31" version="1">MSMMSLSPTTSTSNYDETPSSKRRRTTSFTAAANGGPRSEMASPQDPSSGHGASSSVAAAHIPKRGARACTNCRKGKNRCEGELSGAQCVFEKPEKKNVQALSTASVERLSRLEGQYLVMQSQMIGMQSSLDRILSAIQSQNQAMVHVQQPPYPQQGSSRDSPNMPEPHPRGRAFPPLPGFAPPPHKYATYGIVPSTAPSSDDESEDTLPRSTLNAPIEALQGLANAAAEAAAATSTSPPRQVKRKRAEPTPRNAFPHVVEKGLVSDTEARELYHIFFSGCHIFIPVFDPSYDTYEGLMERTPWTFDALLAVAAKIRSGTGPLIPAFYKCLEEAQGIARSSLFGPVVRKEAVQGMLLLAAWSTNGWLPSGHAMRMALDLGLHRALEKLAEHPEKKRSDEEERNLVVSARIWLCLYWFDHQMSLGTGRPIVLRDESSIRHCRVLLTHPLASPTDVRLISQVELIAQKTQIYETLSPLNGQVNHNTLSFIRRANIALDKWWADCDELHRQTMDEEALPRKILAGELHYAKLWLVCVALRGVSWDKMPFEQRELAFQAKDAASNCLSNLLDSPTYRAALRYAVHDTLVMAAFSGLFLLKMANLFPAELDLAAITIQVEQLAQLLSDVAAERYALTLRIMLANLRRKVGLTGGGLPPQNAQMPTTGGGPGDIPGQLMPGGPGGGGFNIDPSIAGPPPPFTVEEVGPWAHDQRMFNPQAIPLWLQEQSLTDLGLPVNGSDGIFLQMGNQNGWMGDFPQMPEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRA1</accession>
    <name>A0A2G8SRA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_01959</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRA1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRA1"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF302">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-5 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL36296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="38205" checksum="CB2CD6D98236A646" modified="2018-01-31" version="1">MGCVQSSGIDDEAKARNDEIENQIKRDRMMAKNEIKMLLLGAGESGKSTVLKQMKLIHHGGYNEQERDSYKEIIFSNTIQSMRAILEAMPHLDIQLSPQNDARRSIVLALPGQIEGDLLPRDVVDAIRGLWKDPGVKEAVSRSREFQLNDSAVYYFNAIDRMSAPNYMPTDQDILRSRVKTTGITETTFKVGELTYKLFDVGGQRSERKKWIHCFENVTALVFLVSLSEYDQMLYEDESVNRMQEALTLFDSICNSRWFVKTSIILFLNKIDLFAEKLPRSPLGDYFPDYAGGDDYDAACNYLLHRFVSLNQSAATKQIYAHYTCATDTQQIKCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST09</accession>
    <name>A0A2G8ST09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST09"/>
    <dbReference type="OrthoDB" id="3270129at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="115" mass="12217" checksum="36E61B8314BCF462" modified="2018-01-31" version="1">MSQQWVVDHVIKASILHPSGAVTKAHPTAIRRGDLVDVAATVEVVNMRGRGGWHSEVMVSPNHILRLKTAVQLRAEGETGSKAPPVSPSGQGVSALPELPVELGFDALHSDEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST59</accession>
    <name>A0A2G8ST59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST59"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST59"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="487" mass="54529" checksum="7ACBF3F164AB88DF" modified="2018-01-31" version="1">MSTHSLEKGHDSRVADVETEARARHTGDEEFGGTEARKKLEKKLLRKLDARMSILIVIYILNYIDRNNASAARLRGFEDDLHLKGQEFNTLLSILYVGYIIMQIPSNMFLNYIGKPSLYLPICMVIWGMISTLTGITTNFTGALLTRFFLGFVEAAFFPGALFILSKWYKRSELGVRTAVLSCGSLISNAFGSLIASGILDGMEGKLGHSAWRWLFYIEGALTMFVAILAIFILPDFPATSHNWLSPEEVRLAEKRMEEDVGVGDGQETESGGRFHGFNLALADWKVWWLGVALTSMVVSLSFNAFFPTLSATMGYNSTVTLLLCAPPWVFATIVAFLACRHSDRTRERFWHIAIPLAFGIVGFVMAASTMALAARYVSLFLMAQSYAGFIIFLAWISNTIARPPSKRAVALAFINSFAQLGNISGSYVWQKPWGPSYRNSYAICIATNGLCIVMCYIFKLHLERENRRFAKREQEDGQPEGFRYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST89</accession>
    <name>A0A2G8ST89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8ST89"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="834"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="399"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="773"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1678"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="436"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="701"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1678"/>
            <end position="1691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1920" mass="212802" checksum="778FFE63BB7E703B" modified="2018-01-31" version="1">MDPSHSSHAAEIPLPPSPPPHDEPPTSMMAVLPLRDPVDENRARSISPIPPDQGQLANGPSTPTDDATATSPSHTSTSLSQPSTSSPNGVHEPAPEQIEQAAIPPVRSSVERAQDTDDSVPPPTPPAKPVPSNPASPPARRPHVLPGSPRTTNGHGRPSVDSRPATPNGRTPARPSSDSAHKRSLTIAKGHTVSVVLISSALETIAASKEAKRSAPLRESVQRALEMVKSGQGGDKPREIFEPLRLACETRNEKLMIASLDCISKLISYSFFAESSSSSHAPSSPPPSPGPGPSSRHSVSSQAPPPAPSLVDLVVHTITSCHTESTPETVSLQIVKALLALVLSPTILVHQSSLLKAVRTVYNVFLLSVDPVNQMVAQGGLTQMVNHVFARCKVGFPQSESSTTLSGRGGDSPRSSKRPSLVLSPRSSLPLPSPSVNGTNDSNSTLAQEPSEPPSSAASTTHTDTAEETLVESEEGTQLDGVPNGAHHEAQGSDSVPGGSVHEDEEELGGLGNRQLTTNDLFIKDAFLVFRAFERDLKSHSMRSKLLSLHLVLMILNSHMPIFVSPSAIIYSSSSNEATPFIQAANQYLCLCLSRNAVSPVPQVFEISVEIFWRVISGLRTKLKKEIEVLLHEIFIPILEMKTSTLKQKAMIVSMLQRLAQDPEALVEIYLNYDCDSEAVDNIYEHLMNIISKIGTSPVSLASQKSNDPTSPALQPQSKHQHGTQVPPSFSTAALSVPGNVDTTTIGNSEAQLRRQGLECLVSVLKSLVAWGTASSSLPEHPQDSTTRSMTEESRLATTPRDVMTPDLPTDRLSPGGADMSRGQTPDLVDDPSKFESAKQKKTTLLEGIKKFNFKPKRGIEFFLETGFIPSNDPKDIARFLLDTDGLAKAAIGEYLGEGDQENIAIMHAFVDMLDLSNMPFIDALRSFLQAFRLPGESQKIDRFMLKFAERYIAGNPTTLFANADTPYVLAFSTIMLNTDAHSRQIKVRMTKQGFIANNRGINDGQDLPEDFLTAIYDDIVNNEIRMKDEIEAPTVITPSPGIAGVLATVGRDLQKEQYMLQSNNMANKTEALFRTLMRSQRKSAKGSDQFFSASHFIHVRPMFEVAWIPFLAGLSGPLQDTDDLEIVVLCLEGFKAAIHAVCFFDLELERNAFISTLGKFTFLNNLGEMKTKNMEAIKTLLDVAVSEGNQLKGSWREVLTCVSQLEHMQLISSGVEVPDAGKKGRVRKPPTEELANESRSTHITVAADMVFSLSHYLSGTAIVDFVRALCDVSWEEIQSSGISQHPRLFSLQKLVEISYYNMNRIRLEWSGMWEILGEHFNQVCCHQNPHVGFFALDALRQLAMRFLEKEELPHFKFQKDFLRPFEYTMIHNSNPDIRDMVLRCFQQMIQARVHNLRSGWRTMFAVFSAASKAATERIANSAFEIVTRLNKEHFPSIVRHGSFADLTVCITDFCKVSKYQKISLLAIAMLRGLIPTMLESPDCNFKDSSHSSTDDPMIKYWFPVLFGFYDVIMNGEDLEVRRLALDSLFSTLKTYGSTYPVEFWDTVCQELLFPIFAVLKSSQDLSRFSTQEDMSVWLSTTMIQALRNLIDLYTFYFETLERFLDGLLDLLCVCICQENDTLARIGTSCLQQLLESNVKKLSAARWERIALTFVKLFRTTTPHQLFDENLRIEIDGSSSDLQESPDSNEQAMVPAPLSPNSENPKAGVRISLNERRRIFRQIIVKCVLQLLLIETTNDLLRNDEVYDTIPPEHLLRLMGVLDHSYQFARMFNDDKELRTGLWKVGFMKHLPNLLKQESSSASTLVHVLLRMYYDPRPEHQTARPQVADRLMPLGLGVLQDFNKLRLDSQAKNIAAWTPVVAEILQGFVKFDDKAFTRYLPAIYPLATDLLSREMAPEIREGLRDYFLRVGYIQGIVERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STB2</accession>
    <name>A0A2G8STB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8STB2"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF12">
        <property type="entry name" value="EUKARYOTIC INITIATION FACTOR 4B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="82"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="203" mass="22453" checksum="60159B67D1E96067" modified="2018-01-31" version="1">MADIASTEPTHPLADTDAVIDNAEEEEDSEILLMKKRVEEMEREANKLRELQSAAEKAEQSAQGSEQVPMETEEDKAAADARSIYVGNVDYSATPEEIQQHFQSCGTINRVTILCDKFTGHPKGYAYVEFAEPDFIDAALAMDNSLFRGRLIKVTAKRTNIPGFNARGRGRGGYRGGYRGGFRGGSYGYNPYRARGRGRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUA8</accession>
    <name>A0A2G8SUA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">KOW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_01054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUA8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUA8"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000030">
        <property type="entry name" value="60S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="7">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="8">
        <location>
            <begin position="51"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL37361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15499" checksum="C0FE4FEF0718CA7D" modified="2018-01-31" version="1">MPAQPSNFRRFVEVGRVVLLKSGPQEGQIAVIAEIIDHNRAIIDGPTTGVPRQSFPYRHLSLTPFILSTLPRGAGTGVVRKHLEKDGTVEKWEKSSWAQRRAAIAKRRSLNDFERFVVMVAKKARRDRVRKTLAKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUD2</accession>
    <name>A0A2G8SUD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUD2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUD2"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="355" mass="38117" checksum="7DF0CAFFB8120841" modified="2018-01-31" version="1">MRYVWLDCDPGHDDATAILLAVHCPNVTLLGISTVHGNASAENTNNNAARCLYAFAAQEHIRVCPGARKPLIRVERHDPEIHGIDGLGGVEGLPPATNPAVQARLVGDGMPTRALEGMAKAISATWQNGRGSKVTVVSSGPMTNIALFVSVYPDLLDGIEEFVFMGGGVGMGNRSAAAEFNILCDPEATQIVLDVPVKKIMVPINVTHTAIVTKAVLTQLLAPGSAPISIDQPLPKAASPLRYMLSTLIGFFADSYKSSFGFVDGPPLHDALTIAYVEKPELFTCKRHRVDVELAGTHTAGETVVDVFNYRTVDDSWGRDGKNCLVAEKLDVDGFFELFLDCIARCDKVSPLNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUQ3</accession>
    <name>A0A2G8SUQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUQ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUQ3"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="109"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="371" mass="39540" checksum="9F8E92AB40FD8E58" modified="2018-01-31" version="1">MPPSSSQAFAMSNLDSKYRASTPSTSSRVVDHDAPHVTEESHAGPSKPLRANGEHVIKVQPLKRSEMQPSYAQDLGTGEVTHGFYGSMLQALGTCMGFCGAIPCCPCPNPFREVFQGSVGLVSRFGQFYKSVDPGLVQVNVCTESLRIVDVKIQISPIGRQKVITRDNVDVEIDSVIYFQITSPYRAAFGISDLRQALIERAQTTLRHVVGARMVQSVVTEREAIAFEIAEIVGDVADKWGVAIEGILIKDIIFSPEVSASLSSAAQQKRIGESKVIAARAEVDAARLMRQAADILASPAAMQIRQLEALQAMAKSASSKVVFVPMHLQGDVIGPVAGGSGSGLNVVHEESGEGVAGAVSRTGVLSSVEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUT2</accession>
    <name>A0A2G8SUT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUT2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="218" mass="24592" checksum="FCAB1F675AD9BF5E" modified="2018-01-31" version="1">MLHPLQPLQMPRRVRVRLVPDRLPRRLVQRPAPHELDPRADVQPRARGRLLRVVRVGVHAALLVVEAHDLPEQARQARQARQVDRLEERDLSVPHATGDEPLERHQLVVPERLELAQARLHPVVALLQLRRVLLRRLGLARREAALALVLLCARGGRGRLDARDGSRLGLARGDAELRVERRAAVAPTYVQVRAGLAEQVRGLHFLVERELLDALAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLW3</accession>
    <name>A0A2G8RLW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLW3"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="151" mass="16742" checksum="517DBAF3FD85FF2A" modified="2018-01-31" version="1">MSSDLLQNWRTVFHTPYKAVPGVAKRLRYSIRSDMHSKMPGLASRLFIGVQSVEGPRESVLAQRRVEVAFIGGWRKKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSGETTDLATLRAELKEIKERLSAVSVNEMKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLY0</accession>
    <name>A0A2G8RLY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_15201</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLY0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLY0"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="9">
        <location>
            <begin position="298"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL22512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="752" mass="85137" checksum="3E7B0E20C866FCB6" modified="2018-01-31" version="1">MKLHAACSVAVAAIRRRPMLALGAGVGVLTAARLSLIPSVAMRLGQVTPSLGLNRNLGHYRSQSSLSGLFPLSPADSIMTSLKPPQAAPKWTHTPEEVLKLTKEAIEEEGNRLDEIGGLRSEDCTFESVFLALAEGERTADAIIEPLTFYQNVSPSKELRDASNEAEVLARDFGVEASMRIDVFRAKQAAEENIKKSGQKLTAEEQRLVDKMILDGKRAGLALPEDEREKLMKLKKELSQTCLEFSKNFNEENGVVTFTLDELKGVPEDVISGYTKRTESGNDVYDVTFKTPDIFPLFKYAEDPKTRRKAYEKFENRLAVNKPIMAKFLDLRRQIAKLLDYPTWADYVTEVKMVKNAKGVKEFLSDLQQKLNPVGKKDYDTLLALKKEEHAQKGLPFDDKFYLWDYRYYDRKFIEQTLKLDDSLVKEYFPVSKVVPAILDIYQNLLGVKFVELKGETWHPDVQMFAVWEKDARDRTGFGGYCYLDLFPRASKYSHAAVWPLLPGYEKVDGSRSYPLTAMVANLAKPTPAKPALMRHDDVVTFFHEMGHVFHGLLSRTKFSRFHGTSVAGDFVEAPSQMLENWCFEPKVLGKMSSHYESGKPLDAELIDKIIKSRYVNVGLFYLRQLFFANFDLKVHTDQEAADYTELWNNMREEVSLVKGKNLGSGEGTFNHIASGYDAGYYGYTYSLVFAADMYATIFKEDPLDPQRGRQYRDKILRPGGSRDEIDSLKDFLGREPNSDAFIQELFGSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RME2</accession>
    <name>A0A2G8RME2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_15364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RME2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RME2"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF45">
        <property type="entry name" value="MITOCHONDRIAL CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="241"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL22671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="334" mass="36344" checksum="309483A14559C147" modified="2018-01-31" version="1">MSHDRLHHRAIATLSASSRRSARLSESLSAFSPLCSPHYPHTRTWRTMDKSTINELIAGSIGGAAQVIVGHPLDTVKTRAQIAPKAMFKGPMDILTQTLRNEGFFALYKGMASPLMGIAGVNSLLFAAYGASKRLISPFPHLSLKEIAAAGALAGAINAVLASPVEMFKVRMQGQYGQPGDKKLRAVVSEMWNEWGFRKGIMRGYWVTVAREIPAYAGFYAGFEFSKRKFGEKYGKQIPVWALLASGSMGGISYWLSCYPLDVIKSRIQLRATPPEGTPVQYIARELRAVVAEGGASGLFRGLTPSLLRSIPAAAATFAAFEITREYLEKLTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMM2</accession>
    <name>A0A2G8RMM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMM2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMM2"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="34"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="149"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="625" mass="71399" checksum="065A5B244EF46827" modified="2018-01-31" version="1">MDAIYSPKRMSWGAGLLSPLSPNTIDSLESRSRDVQERTFCKWLNTKLEANGYPPMSSLVRDLSDGVRLIQLMEIMGDTSLGRYNKAPRMRIQKAENVNKALEFITSRGVKLTNIGPEDIIDGNLKLILGMIWTLILRFTIADISEEGVSAKEGLLLWCQRKTAPYKECDVQDFSYSWSDGLALCALIHCHRPDLIDYDKLDKNDRHGNTRLAFQIAQEHLGIPQLLEVADLCDTQHPDERSVMTYVAGYFHAFSSMEQTETVSRRVEKFAELMQSVWMSRNDYERRVRELLRSMADMQDVWAAKSFVGTYADALQHSQSFQNYKQTTKRTWVTEKQDVATLFGNVQTKLKTYGLREYVPPPGLSLTDVDRAWNELLKAEAARSRAINAEIRQIKDSLRHKFADLANNFEKRLRLMSSELVSIEGPLEEQVKQVRLLQARIPPFSETLEAVIAAEDECRAANVDENDYTAFTVEDLRFELELVTGSIAKKLAFIDNQIVSRNMTNLTPAQLEQFESTFRYFDKDESNTLNQFEMSAALASLGIVYSDEDMDLIYDQLMADYGAVTFEPFINLLPYVTELDLRVAHLPATAIEFLRQAMPSTSNGVGEPEYDYERWLDEVFEQDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMX5</accession>
    <name>A0A2G8RMX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMX5"/>
    <dbReference type="OrthoDB" id="2838513at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04076">
        <property type="entry name" value="TIGR04076 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="14740" checksum="10DF2132960178CE" modified="2018-01-31" version="1">MSSASTSSNSNSANVVQDETFQLYDLRVEVICPPGQRIMCGAKEGDYFTLEGEMLYLPPGQGISIYSLSAVLPLLAAKQHMTAKNDWMSTDAEVACPDPCCPSRLRIIRTGVRTFKHGDTTLVPLSPPPGEAPHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNA7</accession>
    <name>A0A2G8RNA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_14303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL22996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNA7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNA7"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL22996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="600" mass="63386" checksum="3756575A5E97236E" modified="2018-01-31" version="1">MPPPLDHEMAFDDDDGMPPLVDNPLPPMTFTFAADLPPISYTSYDFAPPEYPPEAPAIDMNMYSPQETTVLDLPRASHAKKRDASYIPRPPNAFILFRSSFIRGGHIPGEIEGNHSALSKIIGKCWKALPREERQVWEAKAIVALAEHRKKYPDWRFKPAANALAKVKDGPRKRGNRKGRGQSEKEERSREKRCAKIADLLVAGKTGSDLAAAVEQYDCETGRGRRPKDEGASASVGEGVGAGAGALASVELPHVLGEGTGCGGPAVAEGVNDNVKASPVVGLPVPSASALTVATDGLDVKPLAIRSAVDGRFKVPLTAMFKRSSSAPAPRARTPSGELPAFLSHRRDSFSAAPSSFSRATSFNASGATREEMAEVGFGSAAAPCKGVGHAFADSVSSIQSFSADAAAPLALPRNAVDGVTDRVLDSFGFAGSTYSSPSLPAFDFDADGHSSPIQSPIDTPLVFGWGQESDVGSPTSISDMMSEAYAPAPSPSSYSSLEGWAGSPLPKPAVSPINSPLPRVCHYVDSPSVMKKAFEAAACAVYDWSVERLGHEDDAHGHGHGHGLPVALGSAHAFYPWPSDVDAAYAFPAVQLQCRQDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPH3</accession>
    <name>A0A2G8RPH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_14725</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPH3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPH3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070330">
        <property type="term" value="F:aromatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023206">
        <property type="entry name" value="Bifunctional_P450_P450_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000209">
        <property type="entry name" value="Bifunctional_P450_P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="13 15" id="KW-0408">Iron</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="496"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="675"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL23414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1062" mass="118422" checksum="4BA6F6D115B2A9C6" modified="2018-01-31" version="1">MTTPIPSPPALPLLGHVTQIDKEVPLRTFELLADQYGEIYQLNLITRDTIIVSSYELMNEVSNDKRFSKAIVAGLVETRKGLGDGLFTAYPGEENWGIAHRLLMPAFSTSKVRAMFDDMVDISSQMIQKWERFGPRYVIDTVEDFTKLAFDTITLCAMSYRLNEFYMEQSHPFVQAMGDFLLESGLRSNRPPIMNTLMRGSSAKFEADMATMNQLVDELIQDRKTNPSEKQDLLNIMLNGVDTKTGKGLSDENIRFNLLTFLVAGHETTSGLLTFTLYYLCKNPEAMRKVREEVDEILGDQPLRVEDIGKLKYISACLRETLRLSPPAAMRAVEALEDATIADGKYFIPKGARIAISTRKAQCDPKVWGEDCYEYKPERMYGENFEKIPQNSWQPFGYGMRACIGRPFAWQEAHIALAMVIQKFDITMDDPSYTLEIKQQLTVKPKGFYVHVLPRKRSASPIAVAPTSTLVGLPQVSKGAEEELEAERNIDAKHRLYVVYGSNTGTSQTFAQRIASEAPRHGFKATLGTLDSITDHVPTDGPLIICTASFEGEPADNATHFFEWIQSLKGNEFESTKYAVFGCGNRDWVRTYQRIPKLIDSTLEERGAKRLLERGVGDAQAAEFFEVFDEWEAKLWSALATEYNIEVKEQPAAVSSLSIQTVDDGTSRASVLRQSDADLGKVTENRLITSPNAPAKRHIEFELPEHMTYRAGDYLAILPTNPQRDVQRVTARFGFSPEQQIVLGSAGPTSLPVDRPISIAALLSGYVELSQPATTRDLRILLSVESSDATKATLQDLQASYSEKVLGKRVSILDILEDHADLKLPFGTYLEMLPAMRVRQYSISSSPLHNSQRPSLTVSVVEAPALSGRTEPFLGVASNFLAGLRPGDVVQLAVRAASSAFHPPEDPSVPMIMFAAGSGLAPMRGFLQERAVQKQAGRDVAKSLLFFGCRAPHEDFLYGDSDLKEWKELGIVEVRPAFSRSDADSLGCKYVQDRVWRDRLDVRDYFDNRSAKLFTCGSGKVAQGIKKVLTDIIKEARGCTDEEAAALFERAIQGRYATDIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ98</accession>
    <name>A0A2G8RQ98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ98"/>
    <dbReference type="OrthoDB" id="2755252at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="424" mass="47120" checksum="DB843E4C98F667FE" modified="2018-01-31" version="1">MSSYISSSAINPLVHVYFFNPVTGSITYEPMRSPGAAPSNSPRLQYIPGQPKPRTLGKDTRGLIEDLPIRHNHAVYFIATPPSKWDPLTTKDRLSKIRRAKLHVRKMELQVLELEAALTQDDHDDHDDYESEDVSSCYSYDTSSLSIGDCSGESSISSIEESQRSRDSFSTDDSLSDHDTDPEEDEPGEHRDRQGDDKNEDDDNLRNNVASVTASVLPSAPSPETSNSLSILHAHPMTPSESPPKPLSRYLLSIPKTPSSLRQLTHPPSVDNVPSTLSTLGKQGERRSNKRKAEDFEDSRTVKRLKTAPPTDPQAPIPSAPVTDLPRADQQSTSLKRKREDDDDVIASGSSQQDNSDSGPAAKKLRTAPEPMIPRRRRRRPKVVRPLARKMWDKLMKTKLKALKLGATFSDFGFLPAKKTRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQM3</accession>
    <name>A0A2G8RQM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13542</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQM3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQM3"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="510"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="513"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="60468" checksum="5BC062508242E1C4" modified="2018-01-31" version="1">MALSKHINPDHLIQISKDHKAHHLHHSSTNHHAVHAYGARYGTDPIPKYRIPSKGTDAEATYQLIRDELTLDGNPSLNLASFVHTWMPKQADQLMMENISKNLIDQDEYPMTQMIHTRCVSILADLWHAPSTQQAIGTATTGSSEAIQLGGLAMKRIWQEKRKAGGKSIHEPGPNIVMGANAQVALEKFARYFEVEMRLVPVSEESHYRLDPKRAMEYVDENTIGIYVILGSTYTGHYEPVKEMAELLDEYEARTGHSVPIHVDGASGGFIAPFATPKLEWDFKIPRVVSINTSGHKFGLAYVGVGWVVWRSKEFLPKDLIFELHYLGSVEYSFSLNFSRPAHPIIAQYFNFLHLGFEGYRNVALQDLANARLLSRALEKSGLFYVLSDIHRPADASVSVVQKAIRVDEQNVENYAPGLPVVSFRFTDDFRQQHPDIQQKWVQVLLRAKGWIVPNYELAPDLQNVEILRVVVREQLTAGMIDRLVADLVEIVENLAKEDTPTHALAATSNHIHTTERHHGRLEDGSGSKPSGTYAKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQZ9</accession>
    <name>A0A2G8RQZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FHF complex subunit HOOK-interacting protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQZ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQZ9"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045669">
        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19314">
        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHF complex subunit HOOK-interacting protein C-terminal" evidence="3">
        <location>
            <begin position="762"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="638"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="953"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1020"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121263" checksum="B027FBEF6B635170" modified="2018-01-31" version="1">MDYFSKFLRSNVPPTPKTEVDHAQEFHKSWVLIKNTLLHPDERQLSRGIKSTDVPAHLQSMVDSLVWESTRTEEGATGACLEYLLKNDVLGTLVKLSESDRPFGIQAEVLRAVQNMVVLLDEQFLVHSAVHKAVLRLLRNCVGDDIQEQLDGRNKPMGAAGNASRTQPSEYEEDLVNLLCILCSRIRTYRELLMIFFHDKQWYRPEPLFAVEEEDEEEDEVEPPLSTHGDQPSSESTLTFPTAPAPSQQTDSYTLGSSTTKKNEYEFLLFNYLLRFVHREGQIGDFARAGLLFLMDVAMSPVDLSHKSEESLHTSTSSLPSHDPDPNTDAALALAEYVLDGDFSDVLAAGLAAVYSLLPTKLEVRPPIPAESAPGTAMILGSSSAPEPSLEEKEKLEAEKERSRAMGLEESSSPDFKARLDHFLKLLEFLQDVFRRNKVHDAADGSLDPSALVGSAIVQSILDAVRRVFLENILYPSILECSDADGSAVAVMSYIEIMIRTLENGQLADLLIDFLMSEDNNEDLSSSRPRPHSMLNLGGKVPPPSASQAELKRRRRKSTAMTLLEMEAPGARKQSSYFTSMGRFTLKDLLVTSLRSKSQPTATAALQLLQSLLFQYCALSVDRLLVVIPDPQATSFPQPAFLPDALDVPPPPSKHENGDDDDDETFVYPGSEDTKEVEHVHPKSVIVFTQPDTTYWTHEREMGLYLALVARVDPNHAEDAFSTGYDHYLHDAIFSIQNQSCFWRDLDPEARAKLKHRLNPNDPILSLVLQSLRRFFSNSPETNMALTGVLATLALCPDRSLAGWLTFAHKESAEPRQQDDLMPFDDDGDDRSIDFRIEEKLASESSALPATSMDEQSRPVVHSIFHGLVGQLERYRQMVHNFDQYLQERRQGLLFNENLTDALTLALDFDTGATQKSAGFGSQLSAALLPPAEVPAKPKPKPAQSVQSLVSFLTPKKSRPAKPPPSEPTTPSRGARAFEASPFGPHYQKTGAIVVEPYLAPAPSSGPWTPAKSRKFNADEEDVFGSSGQWGESRTPSQVVDDSEEEEDVPKIAHVTLSQLLDNVVILEESIKELVAIIHARRSLGIDSIRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSC0</accession>
    <name>A0A2G8RSC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSC0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSC0"/>
    <dbReference type="OrthoDB" id="2592022at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="293" mass="32474" checksum="2A4BAFE35BC21624" modified="2018-01-31" version="1">MADTLSTAINDDHPLVLELSSLRSAVSRYQHEAHAVSLKLQRHSLEASQALDHARALGRENARLKEELAILRAHPDSTPSPAATQVPELTLALRRLSDKLTAVEETLLVRTKEVVDTQSELAGVQHELEAARALTAESRAREEEGLARERAMEQKVRAAEEGRRMADLVVQEYADLVRKLEGRPKASFPPPSTSTSSIDLHRSSNGSTTTLVDTLAEGKLGLQKLLEDFNGRNEQLQADIAQLHGDNGLLYKELEVAREGARHDRDELAKAVHELDKYRADDNTATKMVSRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTV4</accession>
    <name>A0A2G8RTV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTV4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTV4"/>
    <dbReference type="OrthoDB" id="3164835at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="532" mass="58830" checksum="FFCD8494A1DD1149" modified="2018-01-31" version="1">MSNSQPMTLIFAGPPFDNPAADVVIRSPDGVHFRVRSAIITEASPVFSDMLTSDQTGRTTDGKHLLVIAEESTVLDPLLRLCYPVTDPVFADLKDVRLILAAAMKYQMTEACTLLKKQLRSYMDAQPLRVWASACLLRFEEEAQAAALALFGKEFPIKAPPEFEQVSSGDYFRLTKFLRAGGNVPEGFKFWDSLPEDIPKPEQERQKRHSLFQELGADTPAIAFQSRPYADIVCRSSDGVEFRSHRIILCLASSVLSKKISRLCPDAPPATTTTASTLPILEFKDTPGSVLGPILEACYPTKRRHPTQFDLHQLMSMTACARKYDMQQAQDHLCRGAFWLASRERPLASYLMAARMGFSDYARSTLPNLSGELHTYGCPPEMEDTPATVYHALLINRHQSSIATSRLTGATVTQTSASPSRAAQPGASGPSTGSAPTVAKSKPKAKTPEAPDLRNPWLLNVWRQTAQGLQGCRSNELWKFEPHVPKLLKESLTKKIWCSKCEMNLGLMSGLHDMYQSVRAAKFDHDVSVPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU43</accession>
    <name>A0A2G8RU43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_12924</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU43"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU43"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000047">
        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL25036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="181" mass="19002" checksum="4884310E5460B98D" modified="2018-01-31" version="1">MPPPKSKGGKMLSLINWRLKVTINDGRAFVGQMLAFDRHMNLVLAECEEFRRVRPKKKPGETEAGPMQEMKRTLGLVILRGETVVSLSVEGPPPVTDDDKKNVLPFGPGRGAPAGRGMGMMPPGGPGGIARPPMPFAPPGMPGAPPPGFRPPGFPGGPPGMPFPPPPGFGGPPPGFQPPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUA8</accession>
    <name>A0A2G8RUA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12984</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUA8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUA8"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="115" mass="12074" checksum="D9FE44AD740F5D78" modified="2018-01-31" version="1">MAPTKKSKAAKSSESIASRLTLVVKSGKYSLGYKSALKQMRSGKAKLVLIAANCPPLRKSELEYYAMLSKTSVHHFAGTNVALGTAAGKLFRVGVMTVTDPGDSDLLTVAEGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUG3</accession>
    <name>A0A2G8RUG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_12865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RUG3"/>
    <dbReference type="OrthoDB" id="20689at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="197"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="260"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1030"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="841"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1272"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="670"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="845"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="872"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1400"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL24978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1441" mass="158184" checksum="1C097B3C42CC6D8D" modified="2018-01-31" version="1">MSGPDHQKQHLSLSSQSSSTSSDSATLVYIAMASDQGSDHDLEPPSTAQFNGGPSSSPRSDLHPPDRNVPVRAATLGTPHDLDQRPPVRGDDRPHARSEDLNHSSSWGAHDPSFTDRAHTQSPSPAYMASSRPGTPGSNSTHQPLPPSSSDHSESSRSRPRSVHSDSSLGSDPPTPGGSQLGGGSTTTHTSTSVASTPCAACGKAMQGAFVRALGAVYHLQCFKCMDCGTVVASKFFPIDGQDGKQHPLCERDYFRRLNLICAKCGMALRGSYITACNKKFHVEHFTCSICPTLFGPQDSYYEHEGDVYCHFHYSTRYATKCAGCSSAILKQFVEINRNSRDECWHPECYMINKFWNVKVSTRRPTSLPPPAEDGETTQPIEPPYVEEERTETAASLREKQIRMEQQVYRIWTVLSAFEESSAACISDMLRQVSNGQYLDAIRMAEKFILHVEVLFATIDDLEYHFARLKLKGMSHVREARMLCRKTVDLFTLLSHTQETGARRMGMTQELLALVTGLAHYLKILIRIALTGALKLEREQDVREAITNFLDKLHMLAIQGSNPSARRIMKRPNGELIPQSDSGNLGTQGVIYGFKSLAPENAGESPFSASPKDPVLAKVPVVNPPSDLCVKCNQTVEEDCVRLGTYQRWHSHCLVCQTCGKAAAMPTVKEPPKALEDKDRDGSQLGQEKDSKPKASTARRPPANVGAFVFEVETVKETTSFGVIPTAIFCTEHGHAGCRSGFQAVSRLEQYAFLLNVALRRLYVLLKKRGVVPLSPAVPGQGLARELEDDPYRNSGDINRLRSVHLDRKLSSTARVAKRSTIVESPAGKVAHPSDIAHRPHEVAAARTPAPQTAQQGTARSQKAPPIHTHSPHPQQQRSLPSPGTIDTSVGSQVIRPAFARGNTAIKIVDESGPSSPSGVGADDDMVGGIEDGITLADIPQLVEAAQAREQRRSLPSQSSIPYIGDLSPLQLAVVKHAAVLVLQRSPLRDQFDLDEILELVEVKKSSFWKQLFKAGNDKKNLKKKGVFGVPLELLVEREGADSLLGAGRTPLRIPSFVDDAISAMRQMDMSIEGIFRRNGNIRRLKELTDAIDRDAASVDLTQDNPVQLAALLKKFFRDLPDPLMTFKLHRLFIATQSLPTEQERNRMLHMVSLILPKAHRDTLEVLFVFLKWVASFAHLDEETGSKMDLPNLATVICPSILYSRGANAMRDESFGSIRVVTALLENQDEFYCLPEEFLPLLADEEYFNNCMELPSREFLKKVDNYMRVKTGGRTPGLTSPTIGNATFNFTPGTPRPEDPRSMPPRATQSNPQFLDRPPMVNATPSDGMLRNGIPQQRPQPPSMPHSPFSFPSPGAPPQSATQSTMGAIHSPQPRMPANMQGIQSPGPDWAVGPPAVQDPNRPSSRPPSSTFVNPNMPAATSRPSSESPRPYVPNGQHQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV17</accession>
    <name>A0A2G8RV17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV17"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV17"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="326" mass="36283" checksum="CD8EDE5E3D48F232" modified="2018-01-31" version="1">MSAFARPCLLAVFTAARALAYLDVADRPARSSRGHYSEHSTRSTSPDSASTYAVIFIPFAFSVSFLSMSHEHSHGPGQPTHSHGPPPQIMQQQQQQQQMVMRPPDPLMQALIEESFRPVQLALGPPENAIVLCGPHKQEKCTQCNVDYRALNRLSRILVANPNLRCPPPPQVVSQNLSAAVNNTKDEGNTMFKNGMHVQALQRYTMAASIAVQRPPWEAQQLMREELSMILSNRSAAFFEAGDFLSALVDAETVITLKRPWSKGHFRKARSLMKLNKYHEAKEAIQLGLSFEPNNQEMLQMLADIESHLTTSAKSFEQPSQPIPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVC7</accession>
    <name>A0A2G8RVC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVC7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVC7"/>
    <dbReference type="OrthoDB" id="3220652at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="380" mass="42659" checksum="65FE2C6023E9F483" modified="2018-01-31" version="1">MTAPPLLENFKTTDFWFPDGNVILLVEDIAFKVHQGQLVRHSDVFRDMFSLPQPASETIDGVPWVQLHDDPSDVLHLLRALYDGLYFNKPSAGDFCAVSAVLRMSTKYLIDHLRERCLARLEADWPTTLVGWDRREQQATVDTRYNPREHFPHPVLVIQLARELSLDQLLPCAFYDLCRYGPRKIAAGASTIPALLPAKVLAQAHPPIQTQSSSTSAANGHVVQLRLSKPHLRATFLGREHGQRFLADFIQRELHGRAISANCANRAHAGGHHCRESYYFIMLNLLRAVSGIATGRDADPLFSLVQAVEMLSRTDFSDGTRQCGLRICASCKEDFSLAVAKARKEAWDLIPEWFGLREKSKGEQQPQTPEAEQEKVQGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVT5</accession>
    <name>A0A2G8RVT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase family Tnp2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVT5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVT5"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="94458" checksum="EA0F1F9315128B4F" modified="2018-01-31" version="1">MVPALYRASQQIDAEPEDRWSIVADARPVKRSRYVGGQEAGGVEGERQENGSANASGSAIQQGLQSEALSVSGSHDAGAQAPPLPLPSPGSAAQSSFFPSDNHDQLDSTADLDAAISNLQQSVWAGRTRSYRPPTVEDAAEDDELEEAERDLGGPELSLEDREVWERLHVEEQGLAEYEAISVWDELAETFLREGMISGEDLTEDDMRILRPFSLKVDTHVSGNTPSWKPRKVFVYLPIIPRLKVFLASKPMAKEMKYRAEEQAKHTPGVIRDVTDSENYRALLDKHVTVDGKSLAHKYFDDARDVALGLSTDGFAPFKRRTKTAWPLILFNYNLRPDIRTHLDNILGLGVIPGPKKPVDFDSFLWPAVHEFLRLSVGVYAYDALSNAFFALRAYLILIFGDILAVSMVMRMKGHNGACPCRMCEIRGVRIPDFRNPIHYVPLDRARHPHVLGDPEAIQMYDPSHLPLRTHSNFMTQAKEVQFAPSESESERLAKLYGIKGTPILSALSSLSFPSSFPYDFMHLIWENVVKNLMLLWTGKYKDLDEGSENYQFSSAVWDAIGSATADSGNSLPYIFGPRPPNVATDKVSWTADTRSFWTQYIAPVLLRGRFLHDKYYDHFVELVRLINICLGFDITTAQVNDVRSGFIKWVQKYEDILAAGPVWASWAFAMERYCGALGPAIRSRRFPYASLNRYVLDYAHLTQIRLLYGLQDTLPIRLTPKEPGKIYKNYDTRRLLPSHAIFTPDRALTDKVIACLSTRFNALPAAVREALPAMFGQWAKFRILPAGDTIWAADMVPHTEDGRDASFVRYELLVDRNTRYRNRPTDFVSKTFWGQLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWE8</accession>
    <name>A0A2G8RWE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11554</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWE8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWE8"/>
    <dbReference type="OrthoDB" id="5420143at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573927" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="187" mass="18511" checksum="5CE1B31CBD65B739" modified="2018-01-31" version="1">MVSFKLAALALPVAVANAITILGPSETNFWVQNQTNTITWQFNAGDPSPININVVNANNQTLNGAFAIASFVNVSVQTVTVTNVTLRPGDGYVVEFVNTTNPAQIFANSSTFTVKSPGSQAAPTATLSSSAASGSATSPSNSSASGSSSASSTQAAAGANGAVTLASAGILGVITACAVASLSGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWY2</accession>
    <name>A0A2G8RWY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWY2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWY2"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="319" mass="37063" checksum="D516C281B0CA6DA0" modified="2018-01-31" version="1">MYGDAWYQAVKSASSFMAQATNHVEKTLDDSKDYVYSSWDDNRIRAYLEEHGVIEPPATPREKLLARMKDTYAAATTPVWKAWSDSYIHQWLVDHGIIKDEATKRREDLVKRMQTYYYGVNDKVWDTWDDSQMKAWLVAHNIVKSDAQLQREKMEKLLTDNYVHAYDTTWGAWKDSDMRQWLIEHGYLRSDAQRTRDELIKLMQDKYGEAAAKADNYLAWPDARLRAYLLEVGVPESAIPKARDDLLQEVRVRWYQAGWRASWLWRRVKEYFDSGVEVAEDKLGMILDILTGGTEGAKEGAKTGAAEKQQTQMTAKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXD6</accession>
    <name>A0A2G8RXD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RXD6"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="242"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="972"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1067"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1397" mass="146480" checksum="EF47C59BAC9C1043" modified="2018-01-31" version="1">MATFFSKVFPRKKDKETSNKRNSASSLLEGKFEAVSPTVSPSAANFADSAQKLKDPGREKEKEKDSAFSLFRPRSRPVSPPPSDTRKTASAVPHLTLNLPVPKEQRSRALGVVFEADPNDTSTLPDNVIGERRLTPLETLVLVKACSQAIVTHGGLETLGVMHPFWYSASPEVQRKLISLFILSLAPKSPVTTLSPSPSSATMNFTTELEYTRSPHDLAAVLRWALRHLCLEGDTFGTSPEQWNWYQAFAEAERKSSYPTNAFTTALVPQIPPSHHQLLVATLDIVSSLASHAEHNSISGSKLSKFLGLWLLTASRSEDGEDWNTFYARWERAGRILEHLFLAHIRDETLRGTMPLRLTELVKGYPYHSRSPSADTTPPADDNLLPRPRFSTRQYDALFVRVETELPDAKAAKPKSHPLRLVSDALKSEVELTDAQHKGLWDALRTAARAKDDAEPILASVDGYPSLSRIFADETTRFLSFVPAESGGPDTTVPAIRMPRPHRRRSTSLNSPARPHVNGNGNGKTEVNGKSAHTPVSPTSSPPISPKDWSDFSTAGFGESTLGKDFAKTLLDTDVEVTTPRADNKSPKKGKATRRSSVDSPFSESAARAAELAVPPSPKPPKSKSTVVSIIKLDEAFIDFWHDALLDPIAADWPNFVVAQLKTISGVESDGKPVSWLVLEQRFVAPPPPPQTATDETAASPTAARARASSPRPSLKSDMASRRSSTFSAAKKRLAFFTSASHTITGATAKSEAKSAARRQSAKPAKISELGEILPEVEEKPEEKPTVPEKDAAPAPAPKEPETEAKPAEAVAEEPKAAAVDSTPLADGEASSSAPLFPVTPTAADFPAVPIVSAIAAAAVVTPVAVEELKTEDAPAEGALEHKLEVPTDASAPTDDKTLPPTPEPVVLAGETPGPQVALAMSGPAADEEVPAPEPEAEVAESAPAAVEETKADAVEPVVNAPAAPVEPEPVAEPAAPEPVAEVSAAPEPAVEEPVISAAPVVVEESAVETAPPVVEEPAVEEPAVVEEPAAVEEPAAIEEPATVEEPAAVEEPSPAAPTEPAPLAPVEPESAPAVVEPAAPEAPAEEPSAPVVEEAVPPVQESAPTVEEPAVVEEAPAPTTAPEPEPEAAPVVEEPTAPAPEPEAPVAAVEESAAAVEESAAEEAHAAEPAPAEEPVTEVSSAPVEPEVPAPVVEETTVTEPAVEEVPAAEPAPVEEAVAEAPAVVVEPEAPAEPETPAPLEETPIAEPESSVEEAAPVEVAIAEPVEEPLVAPAEEPVAAPAAEEPAAPVVEEPAPVVEETPAAEEAPASVVEETPAAEVTEESAVPGSASVEPPHSPVEANIPVEESAPALVGEPVVAEEIAVVEAATPEVSAAPAEATAEVVGKHENGTATENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXM8</accession>
    <name>A0A2G8RXM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXM8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXM8"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="39189" checksum="D429CF472EA1DB10" modified="2018-01-31" version="1">MSPKMQYVRLGNSGLKVSKIILGCMSYGSPEWQNWVLPEEEGIKQIKFAYDHGIQTFDTANMYSNGLSEVILGDAIKKYDLPRDELVIMSKLFSPVLKEHGMNIWAIGKTPEELGIINQKGLNRKHIFDSVKASLKRLQFNYIDLLQCHRFDYDTPIEETMQALHDVVQAGYVRYIGMSSCWAYQFHAMQNYAITHNLTPFVSMQNHYSLMYREEEREMMPTLKLFSVGSIPWSPLARGLLCRPFDGEATLRKKTDIHQSIYDLGFLPELTGRIEELAKKKGVSMAQISLAWCMAKEGVTAPIIGTTSLQNLEDLLGSLDVKLTEEEMKYLEEPYKSVKIAGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXU0</accession>
    <name>A0A2G8RXU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXU0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXU0"/>
    <dbReference type="OrthoDB" id="2757744at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="54718" checksum="7B549685DF5B7E1C" modified="2018-01-31" version="1">MLTAEFTEAVDALIQDTSLSNKALKARALRYLSLLPKDKLSGPPWAQRIQKAIPKAAVFSTFHLFVALYAVADELKLVAGKRYVSATICACYDRAISAAPVGSEHENQSTTNLIQALDEVASTWAAFVLWPFYAHGADINLNPAPGETLAFWKDPPPRTESERLKKLQQRRWKEQVMARDNYYSFMCGRYDIDWFLRQPNPPEGADNYDCDVIRIIKREVFAQDEDSMSAQDVDSLGTMRGILERYFGADDALLAKAEGPQNMLFVNTSACIGFRTFTWCLHPTKTPNRYKIKSYGPPNYAGSRHVTSRVTFVDHTGTQSHSPSQPQSESPPPSSSQAPAPAPALAGEMPLAAGSTEADPEPVPLPDPALLRLHAALAGLLCLSGADRTFECLFARPPWLPGLERWPAPRGAAFWASVVEYEGEETCLEIDLHQSVEELWEDMLERAVAAGEYERRPAATNSREGSPSRHQGFRDGDACVSNYGLGLALDDGPNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZG3</accession>
    <name>A0A2G8RZG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZG3"/>
    <dbReference type="OrthoDB" id="2727827at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="261" mass="29019" checksum="88E2B0EB56C4050F" modified="2018-01-31" version="1">MTLVQGSDYARLLRAARPLITHLFGVFFCGNSFSIAHFDYSGIHISPQFFILPNDSTGLHQLIRVFLRMTMEMSPYELGCDPTCFLEPSTQTYYQAQFPSFAVTMRGPGVPGSEKPNTAGTVRTVGKPLFSSHSFLGRGTSVWLAFNEDTHEPTILKNSWRTPDRDSEITIYQKIRERIGDEQVRGLATVTGGGDVYFKGEPLSIATVRDSPALLDPTETNRVLHRVTLSQVGKPLYDYTCLEELGIALLDALHGMPMVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0M4</accession>
    <name>A0A2G8S0M4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0M4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0M4"/>
    <dbReference type="OrthoDB" id="2756845at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="118" mass="13435" checksum="1328E373CC36A6BE" modified="2018-01-31" version="1">MHPTLASPRELDAKLELLQQLGYEGRCFFEEDEPNASNPVYLNDTARWIETEYNWALEEAAESATGIPDLFDEEDEEACLPYVYDPTLFAARQSVALPPRSRTRSASQPILSKADKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0P3</accession>
    <name>A0A2G8S0P3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0P3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0P3"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="180"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="493" mass="53750" checksum="DC3A27295F7EA25B" modified="2018-01-31" version="1">MADAEPVAPPLQPPLQDTSSPRDLEPDAADIERYKKWWEERKLRKLRGQYESAFVQLSQLVNENLSAPLNIASVRVRGAVRTRDSFLGSIIDPFLAPSPDEPQTLGTVLHKTKEMKRLLEETDLFSHIEAVIDRSRDALAHPDDVDVIFLAKEKGRYFLNTSTQVGNNEGGASATCRVRNAFGGAETFEANVAFATKTRMSFNASLSKPLSSDLKTRGEVALFGLERDNSSFASSSEGLRGLRAVVRTGTPPTGSHEFGYEAVLRHISNLTPSASVSMREAAGQSVKSSVFHSWTRDTRDDKILGTRGSYTKFFHELAGAGGDTSFYKAEGHGQLARSLFPGVTLSLAARTGALWNFGGKSYFSDRFQLGGPVSVRMFRMNGMGPHDGVDSLGGNLFWSAGVSLISDFPRKPHWPVKTHLFLNAGRLDVMDKSRPLLDNVLSSISKPSISAGVGLVYKLDPVRVEVNFGVPLVASKSDGVRKGFQVGIGLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1E9</accession>
    <name>A0A2G8S1E9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_10751</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1E9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1E9"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="8">
        <location>
            <begin position="158"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL27600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="768" mass="85725" checksum="C29919F1A314C5F9" modified="2018-01-31" version="1">MPARLLESPGESNTINDGNSRAMTRVVHKWGNKLDLYQLFCNINHDSLSPRAPLSLSKTREKSLVLPPTPPRQAHPRSAASSSSPSMTRRLTQELPPLQVSGSSQETPLEWDWDTEHEDRRAEARADAAVHNATPFQVDRKLLKDIVQERMGTQVARIKFLGAGTFHKGYLVILVDRRELVARVARRFMPRLKTESEVATMHYLRQHTSIPVPEVYHYDANPYNRLGGEFILMSKASGIPLSQVFHSMPHNTLVALMENIAMLVIPLFGHHFPMIGSLYDGSSPSNHTAADFSSSLPTPTPATYQRQMDIHDALTRLADAERDTHIGPIVSWPFFGSGRGDLAHPSELNRGPWRSAHAYLHACADREISGVVLENEGKAAPHKLHLDPDEIQTSRHHRVGALPDDCSDASDEWDWEESEAEWDGPGATMYQDYRRMQRTTFLVAHLAEREERVKAEMARFLRMMERLGVVAHGEGDGGGGESDRGGAEELFSIDCHDLNLENVFVDENDNSKITCIIDWESTTTRPLWACAHVPSFLQNSPFTAKLFRATVEKLARNPPIPNVLIRGTPFSVAGLAASWLHHETTGARLRMAHRCIEWDGWEEGLVDSILGPEDQEEDWFKEWQEEGHEHDDHDHEHENDDPAIDNDRQAREEEYTSQSPVASISPSLIALRVSTNGDSDVDAMPRRLPITKSAAANGNGAGTGNGLPVAKVVVAVEKEREKLLNATGDFCGGRGGELGRRLEAWLYVNGDADGRVDLARRWEGDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1Y0</accession>
    <name>A0A2G8S1Y0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_10933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1Y0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1Y0"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013916720" description="GH18 domain-containing protein" evidence="10">
        <location>
            <begin position="19"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="132"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="22"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL27780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="525" mass="55219" checksum="7F72AEA8A4653EA2" modified="2018-01-31" version="1">MRLDKLLSLVALSLLTVAIPAPDSAQSSQASRDASSSTSQSSTTTKSNTNNSTASATSSSINSATTSLRSSVNITSTPSATATSTSATTSTAVASPPPSKNGTTPSKNGTTPSKNGTTGLVNGVLSVGSYTPKLSKYLPVADISWDKYSVIKFGPIPLTKDIGLGLIGAQGPEVENLLKQLVKTAHANHVKVVLSIGGREGSQYFSSMMPQNGYDSASALVSSIHVLKSEYNLDGFDFDWEFPGNTNDGLPCNQRNESDSGNFSLFLRAFRAKDSPDAATAVSATVGLAPFNSGEYGVPLLDVSLAFAEFLDYVTIMNYDVWTPASAVPLVGPNAPLQVGCTFDNRVSSQSARTAVEAWTKAGMPAAKILLGVPTYGHSYAVEPSAAIDASGKLAEYPAFNGGAHPQGDVWDVIPGPNATDVCGNATHITGDWYFRNLVNATDGFLDANGTAREDIWYRYDDCTQTPYAYNKTSGIMLSYDDVKSFEAKGKFVKAMKLGGFAVWEAAGDYNDLLLDAILDGVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2Q8</accession>
    <name>A0A2G8S2Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000029">
        <property type="protein sequence ID" value="PIL28060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2Q8"/>
    <dbReference type="OrthoDB" id="2757163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="409" mass="44978" checksum="AB2E6EA696143A24" modified="2018-01-31" version="1">MAQATGRQCSAPSANFNEDLYLMYFQRLEERFASVGLLGGLYGLLTILSVWSLYALTQRGGGVQPTAIVLSLTILALLASTTIYMIISILSWQTDFATIFMWAGRLLWNYDEDIDFRMPFQNLIGGISEPLQACAGTAALTINVILSDTIVCWRACVVWQNNRIVWAVCGVFLLATFVLGVIDTAFGCNMSLHWSQPLANIPIPGAMYKGFSAGIAACVLSLSTNLLATLLVGWKAWESRTRLRGYFVGGSITSQIEKLFALLIESGAIYCAFWIRIAIVVAFQLGMELPGRRASQTKDTFVRVVGVFLDAGLVPLIAIYPTIIIVFVALHRSHIEEVLTHNQSIPTPHLSLALRTEASRHSDGEDQPQEFEFGVSVMDRQDIYKYSDSPGDVDARTGEELTSKVGVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S390</accession>
    <name>A0A2G8S390_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S390"/>
    <dbReference type="STRING" id="1077348.A0A2G8S390"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="234" mass="25069" checksum="3F0146123E5FFC37" modified="2018-01-31" version="1">MSSSQPPESSTAHRRPNRLDDQARVAPYLTHVVTHHGQLTLIPPQNAGRIRKPTKKKKQSANRNPLDDEEPRFTTAVPLSSSRKLQPASAHIRTRKHAISTPSPASASPTAASSSPRRFDPVIDDPSIPDYPPPSFEDAIAAPYVPPHLSSSGTPDSPQLPPVESHDHDTMSIDSSAQSQYDSEHPMTSSLPSLSAPTSVVSVTPSTIYASPAAASQLEDSPASSHVSLVRTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3R2</accession>
    <name>A0A2G8S3R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3R2"/>
    <dbReference type="OrthoDB" id="2756645at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="276" mass="29774" checksum="28B42F67A3956E8A" modified="2018-01-31" version="1">MAHATARSSSSGIRSDDAPGSGKKLAPTVKAARTLFEELTNAGQASGGAISAVSGVDGKQSPSQPLETMFLESCDITEMDVSFDDIPVELTVPGTAMAGSLEAKTSLLSSGGGPDTVTKLPLVAGWSEPIVVPSSRPTGPTPPSACQLPHRSCKDCHHANTPLTVRQKRFRYLQTMCGSASPALPKLLSAPEPLSERCDWKIKGGTVGDWRKCPQRPRPAYEKHFSGSKFQLLEARRRELDRALRERAAKQMGIPVHMFVHNTPFFEWPTPPGMDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4B2</accession>
    <name>A0A2G8S4B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4B2"/>
    <dbReference type="OrthoDB" id="2749026at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="318" mass="36043" checksum="6125C8E58630ECE5" modified="2018-01-31" version="1">MVWPAVLWLTAIFLSILLGGLAITIMGLNNYLSRDLPTMTPLTWSSWMRAVPIRDGTRVVCARTRVAFSLYALSELFDEAARGILPQLSLLNDSRLSEKIRKACAVARLDNFSQLWVDTSCIDKTSSSELSEAINSMFAWYRDAAVCYVYLADVPRSDDLRRPGSAFRRSRWFTRGWTLQELIAPRVVVFLSREWEIIGTKENLADLVEDITGIDRDVLVHKKSHTELSIAARMSWAAERATTRVEDQAYCLLGIFGIIMTPIYGEGEHAFRRLQEEILRHIPDDSIFAWEMLLEDPREESRPPVASLSQDAAVSDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4F2</accession>
    <name>A0A2G8S4F2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4F2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4F2"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="624" mass="67259" checksum="B4FC5C449376544F" modified="2018-01-31" version="1">MDDPNPHHVDKGKARAHAQDQEPSENTPLLASGSGSLASSRDRSVENPNAARRRLYSRLLSVFLISLSVCVLLFVLLALIAYAWRSRATARPEEIIEHALVVRGPDKVEVLNATQEDGVWLLLHGRMGLDAGSVVGVKTGADDGVLLDWWKGVGRWGIRQLDRVTVTTSEIRVGPRTDPDIVLATVSTPPIEVPLTADPPTREWGWLTPVEIPVRIQPTRDVEDLMRFVRESWKQGFLGLQAMVGQAVVRGGGLEDRGWRSLLTVSHSNIRPVINVKIPSLPGLPRPGSGDDLPSFSDLVHLNSFNIASRHGTIELSANATALNPIPLDVEFEAPQLPFFIALPAPDVNVSPVTVASVHSHPFQFTHPNITFAVSGHVVPLPRDSSGALSTFVSEYISGRDADIQISTPLFPVLVVNTTFPAPHPRPKILHNVSISDMRIKPVGTSMVASGIVRALVVLPNGIEVGVNASRLFPDVLVFDGEVPGPDEPGTNETEPLLSSPPPRRPLPDPLPPRAFAHIVPDDWVPAECREVESAPGYGSTVAVSAEIVDIPLEVLPGREREFSNFVSKVIFGSQGALAGVQGVAAVAVRVEGLPFTSGRDPEMELSGLPFQGSVRIGKKSMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4R0</accession>
    <name>A0A2G8S4R0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4R0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4R0"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="606"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL28760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="761" mass="85828" checksum="008AFC80FB3E3065" modified="2018-01-31" version="1">MPISRSNSEASFILVGSENPEQQQESFAHDWSAAGTGGKIYLHGRHFVDAYGRVCHLRGVNLSGNCKTPILDYMGGCRAYWTCYDRPALHWRWIGHGWVGELFRIPIASSNASVPEFPARRGIYDMEYLEYVRKLLSLFTQYGFVAFVALHQDVWSRYTGGSGAPAWTLEAVGFDLHGLEEPGAAWLKGVRGGGHTEDERGLWPCGYQKLAAATMATCFWGGDMFAPKLKVKGADGREVSIQQFLQGAFLNMWELVARTVADLEAVIGFEMMNEPHRGYIELQSMHAFDYNTDLHLGHVPTAFQSFMLGSGHPTSVGVWTRSFPMPTRLTSQAVLNTAGQKAWLEDGPTQGKCLWEQHGVWGWDQKKHEGVVLRENYFKRDPDTGREIDWYTDFYYPLLNRWAERVRSVTSQDKAVFCEPIPNEFCPKSWQPHRPANMVYAPHWYDLNTLFLKAFGNFSVNVQGLSRGMFPLKTFYWGQKGTRDNFSLQIRNIVEEGYKSLGETPVIIGECGIPMDMNRGEAFETDRWHSQLKMMDAMIMALERALVGFTLWNYNPDNDDHAGDDWNGENFSWFSRKRALPSSWLDYSQTSPTLDNGGRILRAVVRPYAAKTAGVPLLFDYEINTSEFTLEWAIPGTLDPDASKAKAGPYVQMPPRNDMPPLLSNKTEIFYPSALAHGRNVVVRGLSKEDRWAYDEAKQTLTIVTAQNAPGTVHRVTVGVDPLPKAAFEVNDFWSDFSGQILAVSLVVVSSLVLLFSWLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4V3</accession>
    <name>A0A2G8S4V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4V3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4V3"/>
    <dbReference type="OrthoDB" id="2749026at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="306"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="763" mass="87026" checksum="0F86FEAA8AA5F251" modified="2018-01-31" version="1">MRLLDTWTGEFVEKDPRDPDTKYAILSHTWNKVEQTYQELRDIQKQYDPNQNPLNDPLVRCPDGPSGSLSSGSPESGATTGITATQDVPSSSSHSFLRYPPGIAWIMTHLLWGSAPILPNPSDLSPIWDDPELSPKIREACKTARDHGHRYLWIDSCCIDKTSSSELSEAINSMYQWYKLAVVCFAFLSDVSAEDEHDAEDSSFRRSLWFTRGWTLQELIAPGEVHFFSKEWTFIGSKHTLAHLINEITNISDTALLHIERLNTFSVAQRLSWAARRETTRVEDQAYSLLGIFDINMPTLYGEGHRAFRRLQEEILRRIPDQTLFAWGANGTIESLKIAYREAHYSSEPKPDIGLSSLFAHSPQHFRDCGSINPISPEDVVRRLPLRHRFHLSIADYYYTPHGIRTQFPVIPFSKHFARRGRIHWPTYLIILQCEHKDYPGQLLARTCSTPASILSTDVQPLYNFGAKAQPTNRPAIPELLHLSPETLTGLRWYLPRINLYVQTFYIPHSDGHDESEGSSSNRRKIWHDKINLILLKTTRDALLAHGYAVVLRGPDQDHPDTHWLTLSRDTHTITIEYQYSLVTTWYVSEQLFITAHWRVEASESSNPPNFHEVARTNSGTLSWWDQQPWEYERNKSQDTFPSVQLPADIMGAEGWWMDSKPTLIRKNYYALHIEIRHEPSKGPQRSRISAWKEWVETMATRAVSRFTREKASLGLNVGAESEGHGNSQGGSRAEYTDGECRGASEVRDEAPGELPSEGAPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5R8</accession>
    <name>A0A2G8S5R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5R8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5R8"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="128" mass="13849" checksum="AFCE1AD35F7291A4" modified="2018-01-31" version="1">MILYVASYATGLGNVPWQQGELFALEVRGIGTSFATATNWTGNLIVGATYLSLMGRITPAGAFGLYAGLSLLEWLFCVLAYPETAGLSLEEVTLIFRDGFGIRESERLRKEKRALQRGERGARGGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5S5</accession>
    <name>A0A2G8S5S5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5S5"/>
    <dbReference type="OrthoDB" id="3352285at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="296" mass="32442" checksum="2E1178C662E71BD1" modified="2018-01-31" version="1">MGSWKPFCHLVSYQIPAFQDISEDRDHGQPKFAVFDIVLGTIYTVACAIEVFGVIAATTQRVAMVRTYAILALVAAVAIVGAAFLRVIIHFVYKNGLISECEQVAQGQGVTFRFGIWGPRVSDRLNAADAATFCNNAWNRDSLDEILFLIFEILFAIFFTVIAWAYYHQVLDPTSAANVSRTPANPFRGGPAGQYPDHYNRPYDAEGAYAASPWQQQNVGALPQYAPPPGPPPSHSDMGYGVGMGHDNKDKDGNAMKGERDVDVKGDNESDVTKFDDPFADFDGPSKSKTPPPHQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5Y1</accession>
    <name>A0A2G8S5Y1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5Y1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5Y1"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013863137" description="Alginate lyase domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="5">
        <location>
            <begin position="62"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="453" mass="48799" checksum="1D97EEE932A29FC0" modified="2018-01-31" version="1">MSPSMSLLRTALSLLALSARVLSTTSYANEFVDPDLILAKNFRNTTVEAQKTILQWADELAAKAPSGNKHDYMSWAPYWWPDCSSVGNTTELTPQQIWVACPYVVKDGQFNPDGRLVNDVGEFEDMANAILYNALAWALDGSSVYASRVAKYVSTWFVDETTYMAPNLNYAQMERGPKGQNGTHTGLLDLKCMAKIVSGVLILRGGKAREWTSEVDTGFTNWTKEYIPWLTSAPIALAEKAAANNHGTFYYNQLVALQILVGDTAGAKQTVAEYFMTQYKGQIAANGDQPLETARTRPFHYRPYNLVAMITNAKLGQYVGYSAWNLTTSNGTTIKDALEYAIAKDPGQEDPSELWQPVVAVGAMYGDPDGKFAAFMSAHAGGAYPADAQFLWNQPFSDSGFVKANATGTSTSGNNVGNKGQTGSKNGAGAVCVGSLGVLGMVAAAAGVLLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S742</accession>
    <name>A0A2G8S742_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S742"/>
    <dbReference type="STRING" id="1077348.A0A2G8S742"/>
    <dbReference type="OrthoDB" id="3359487at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="677"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL29554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="780" mass="87502" checksum="BFEF6FE76C48DFFF" modified="2018-01-31" version="1">MPPAKQPDDASAKRRRRESDEAGPIESSSDDAEARASPHAPPPPPRTRSAVRKTATKRAKPTTDDVSSAPDPGELSTENDDAEKTDGVPEPEAASDAVSRSSSTTFTGRRAARLEEKYGDLSTQESLDARAAKWTSHVYKHFRPPVLATNKQGALTSRFVCIKNPSKHVDHTLTDESTENLHRHIQVCTPLPPTDTKEITEYAQGVNYSYARLRIPEFRELLRMLYARVEIPSRVTVSRDVKDIFEDSRARVKAKLQALPGKIHICMDGWMSPNVISFLGVTAHWHENGSIQHVILDFIKLTKGHTGAYLAAKLMELLDEFGIVLGVTCDNASNNAKMLKEMKKLNPEFRGSDACVRCFGHVINLVVKVHLSALDDPEDVEDDDDDDDDEVDEAREAADHADIEEDEGEINKRPELVVAEDEQKLARLTLQKIIKLSQKVWNSPTVRDEMSRQAKDAGKKSEVLIRAVRTRWNTVTMVLARALDLRPILFGVCDKAEFNKSQGVRLRRFIIEDEDWPILEQLHELLAVFLEATMAISHSSTPLLHDVIPWIDVMTHHLEDTRDNIEKLPIKYYKHTDETPFYRVAILLHPCYKKRYFARARWPRGWVEASLRLIRAEWENHYRNHGDPANEEDQTGPQRDGEPSHGASKARESAGRAARDMLASLTGADELEEEDTLEEYLEAPLRTKQTDPLKYWHNALVNGTANPGLAQMALDILSIPDQSVRASTVLGSWARYSDLVPEAEAVELLRSKEKGKRKVAAAASDATVSEPGRDVITLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7N1</accession>
    <name>A0A2G8S7N1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CxC2-like cysteine cluster KDZ transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7N1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7N1"/>
    <dbReference type="OrthoDB" id="3257613at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104:SF2">
        <property type="entry name" value="CXC3 LIKE CYSTEINE CLUSTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33104">
        <property type="entry name" value="SI:DKEY-29D5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="97955" checksum="E093F762082791F1" modified="2018-01-31" version="1">MWHLDWNISHKSSQDYYRVFVRLTSNYDAQSVDDRYRELMVSSRLWRHFTMVKRSGRHHNLVLPHRDPHSLAVPCLTCPWPGFNLPVDWKTATPAHLKYIYRIVLGCDGNHSLHKKSKKDDPHDMTLAPAQCFFIDHTTMTEALKEKYWQEEITVLCNGFQVGKAQNPGKFRFQDVSGIVASTCKHVLFRPGSVVDMQRGETNIHHDFSLAGALKGTELLEERGYTYDVICSRLRSMIPRFEKHHPKLVPIIKDLKCLLPSMHLHAHKELCQIVYALAYADGFGLAHGEGVETPWAEFNIAGLTTREMSAGARHDAINDLFNFWNWLKQERMYIFLARKLTEAYAAQERTTQYLAGLTALAGPAKVRDWLAIPFDGAAPTPLTYKEKETAWASSPFLVQRDKLPSAKQAYDHLVEGIRDLTSKPGEHARKSTGHMRREQAQFLMTGIQLESELFDLRLRRDKRKSAAEGELIDESALTKGTWPAWRKKADRWHAEQAKYMPLLGLTVSELSGTSLVEADDDDDDDCEEDEVTSLSGPAVLQQSLNGADSAATPTEVLGLPSDFTPEEVDKYNLKLLAEYEARIRIGQAFDQLEVVRQTVMHLAAFVDAKKEHTHARKENMRANDLNRYSETIRNDAARKYNHIYDRIVQLRGALPTIITDPSDPASYLKRINVPGDLTISNMKVAREQGDRHRSGSWIWWAFEDLMGVVDTAENTPGPSTSKSTRPSRRSQQQDNSIASAAPYTTWFDRAQWFRAWQEKLRCDEAVNCLCADFRATIKGFSGMANCWLAASKGANLEAGERAYALERQCIFKIKSEQCQTAYDKARKTGVPADRLDHTLPYLEAQTSDMTQWGTILPKIHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Y2</accession>
    <name>A0A2G8S7Y2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_08285</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Y2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7Y2"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="41"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL29648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="744" mass="82877" checksum="499A046B89FC6862" modified="2018-01-31" version="1">MSSTVGAVKEAYIALTGETTKAVDLAKDTVDLGNPPRKGITTDHGVYVSDTDNWLKAADGRGTGPSLLEDQIAREKIMRFDHERIPERVVHARGAGAHGYFKVFDNRASKYTFARVLTDPSRITPTFVRFSTVQSSRGGADTVRDVRGFATKLYTEEGNWDIVGNNIPVFFIQDAIKFPDVIHAVKPEPQNEVPQGQSAHNNFWDFAGLTPETAHMVNWVMSDRAIPRSFRMMQGFGVNTFTLTNAQGKRFFVKFHWIPELGVHSLLWDEALKISGQDPDFHRKDLEEAITTGAYPTWLFGVQVIPEEKENDFEFDILDATKIWPENLVPVEIIGEMILNRTVDEFFTEVEQVAFCTANVVPGIGFSDDPLLQGRNFSYFDTQITRLGVNWQEIPINRPVCPVLNHQRDGQKRHKITKGVNYWPNRFEQTGPVPAKEGGYADYPQKVAGIKQRVRGTKFQEHFKQAQMFINSLSDIERAHLVSAYSFELSHCDDPTVYESYTKLLQNIDFDLARLVAINVGGPVPDKAIHPNPGHKATRISQFDFAPKEPMIKSRRIAILVADGFNLGEVVAIRSLLGAGMATTWVVGPRRGPVYPIGEEVEKGVGYNADHHWEGQRSTLFDALIIPSGAKHAQALADSGRCVHWVREAFGHCKPIGALGEGVVFLREAVKLPGVQFAANLSNDNVTTSYGVVTTGQYDLGSAAADIFTIQQGEKGFVSNFAHELSKHRCFQRELDGLTAKVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8B7</accession>
    <name>A0A2G8S8B7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8B7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8B7"/>
    <dbReference type="OrthoDB" id="2764078at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54730" checksum="BA3149B67EA474C1" modified="2018-01-31" version="1">MLVCHKWYAIGSQAASLWMDIDCARHGAFAPVLLTRSLGAPIRLCGLLNPQTDNMLSAVVADNGPRVCELDLWVGSKLSHTTSILQSILAVDMPRLRILSVSRLGSGSANVNGLTVVADPDAPARFPALEAMLLGSFLFVPAHALPQLTHLHLAWLDDIDPSRILDLLRNTPALQVLDVIQSSEYTSPQQPVKPRWASVFLPRLHSVYLWSLASTTVHALMTHLEAPSLASVRLESIRAKSGALVSTPLIPDTLAARTVTRLAFDLNGVFSSFCAAFHGPDLSLSMDIKASGMQDTAQASRWAFDDFPAILSLSGVDELHFQAHVWPDAGADLLLHLAARMPAVSTLVVKHSRSTSTGDDDTEGLMDLARAVVALLSSDDPVLFPSLAHLELIVGDIPEGFCEILAPALAQRALDGRRLRKLRVRLDYAYQARLAMRWMFEAEPDYSGTGVYEHVDSVKIDKKKSIGRAGDEDGEELSNMVGWGEWRDSVQPARHEYWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8I4</accession>
    <name>A0A2G8S8I4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07642</name>
        <name evidence="8" type="ORF">GSI_07792</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8I4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8I4"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF2">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="418"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL30214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="583" mass="65335" checksum="F41DF292E7AE6143" modified="2018-01-31" version="1">MSKRRVSYYYDPDVGSYSYGVHHAMKPQRMRITHELVQAYDMLPKMHVLRPKRASPEAMTRFHTDEYINFLSRVTPDNARRLTYQGSRFLVGDDNPPFEGVFEFSSISAGGSIAAANRLMEGHSDIAINWAGGLHHAKKREASGFCYINDIVLGILEMLRYVPRVLYIDIDCHHGDGVEEAFWATNRVMTLSLHKFGEFFPGTGLLEDRGRGKGMGYAVNVPLKDGITDESYKSIFEPVFDKILDVFRPSAIVLQCGADSLSGDKLGGLNLTMHGHAHCVQYVRSKNIPMMLLGGGGYTVKNVARAWTYETACALGIERDIDLNLPWNEYFEWFGPRYRLEVLENNLEDLNIKDGSLDEVREKCLRYLSELSPAPSVQMHDVPREGLAEHLGLGGVHAHAPIDDLDERLAQHARHVYDLQTQSDQTDSEAESTDDDSDGEASSRDRAGRRRRSSRRLRSGRKRMSIVTSKYFDVPRLPPEFERELDEDDGCGHGHGRSGKKRRFFESGVVWDPVKRVIMERARAGVRGYEHGRVVNGVGGGFGIGIGIKVGDRDGDGGGDGETSRDEAEEMEMDGEPEAEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8S7</accession>
    <name>A0A2G8S8S7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8S7"/>
    <dbReference type="OrthoDB" id="2752592at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64253" checksum="20BAFCF8E4BB8A80" modified="2018-01-31" version="1">MPTLWATVSTVSTHTPEPDKTSSGNSSESESWFRRSLYLPQESPVELVVHCSNSYETAEHSSEKMIEFMLTNAPRTRELHAWNASGIRDVPLLLRSFDASALQHCTIWDPVGPRVWPPQPEMRLQPFFSQGGARLRSLSLAGVDALPSNEFPMLTLLSIHAGYPYSNVLWDTSDLVKFLAGCPRLEEVYVYSKEVFGRNFGPPPPHMSPPPPTRIGLPRLRRLAFTYVPDSHWDEEYEDTAPTGIAYLLSHTAIPSTCDMYLAAIHEGGFYSINPGILNSVRRNVPGKDAVTHVFMRLATKVSDIQLVFPEGSLRLQVPTNPKHYVETTTASDLADIFHNIPELFAYTEELRIHYSDHDTHATLLASSTSFLASLPAVKVLSLIHRPSVTDLEWEDALPPLPVHVEGTESESLAVPCPSALALYLAQPFPSLPPRVWPHYDPGSDSESDPESESEHEATSRIPFPALDTLWTTVRSTGELAHLEATLVARRAALGRPVRRLVISVSVCGAEPDGSNDGSDGLNAQLPALNSLGGAPEEVVLMELGASEEPRVVDWMATLPERFGLPSEIHRDWPTLWYEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8U5</accession>
    <name>A0A2G8S8U5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8U5"/>
    <dbReference type="OrthoDB" id="2757774at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="59798" checksum="86FECE65B4E4AE71" modified="2018-01-31" version="1">MLDAKLNTDVFAVVSEFLTDYADVLSFSLVCSTLNRIATRRLLSMRPVSLKGDLSVQKFHTFLFADAVTRAPRVRALRIGGFKLPPWKIANEAEGSPSPLVDILNSCPNLEHIAMCFADGSTDDESSVVAAIAALKTLRSLEVSDWSENTLDLLHGISSPIRKLAIHSGAIRSPDALDEFLPRLAPSLEDLELMYFRVHWGSTLVALDAEAPGPDGHPPPFRALAQYPAVRSFSAIILIGAPLLDRLQHLFPALDGTLSLGDFDTQINRCPRDAIRAANRRAQDAAPGHAWKKLDRVICDAQMLYVLALRCPVRLVMIDKCSAGTVRYAADALRENPVPRLKLTLKYGRGMLDGVFTPDMAGPLSHFTLCLVYGNKKLHKRDAGAGDFGQLRWDRLLRALLSALRPLRNLTHLRVLICCELHRPGDPIWGKAAYSEKFVDAVRGPAFDFAGTAAALVRAVPSLQYVFLTTCGRFIERVEGGEGARTWRSYDRWDVSRAWRVAVRDAKRPRRLVRLHSDVADTIIRNEELVLSETDKVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8X1</accession>
    <name>A0A2G8S8X1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07629</name>
        <name evidence="3" type="ORF">GSI_07804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8X1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="102" mass="11059" checksum="A3812F30F23805F7" modified="2018-01-31" version="1">MGRRNEPDRSPHELFSTASVEPDHAKRYPYAHLAEPPNPPAGRVLYTREDSAAASPPVRRPAGTLFLSGHLMWQLRPPVAPLSVLESVRGGAGLPLSSQLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA08</accession>
    <name>A0A2G8SA08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA08"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA08"/>
    <dbReference type="OrthoDB" id="2733483at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052839">
        <property type="entry name" value="Mito_gene_expr_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46920:SF1">
        <property type="entry name" value="PROTEIN MSS51 HOMOLOG, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="627"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1226" mass="138650" checksum="3BDBE3DBDC2D6C5F" modified="2018-01-31" version="1">MADSGKDIISCDSISNILCHHCKKWRGEVGKLKRCAGCKVVAYCGKECQKAAWPEHRQVCRKAPPAKETGALIDFGELGYPMPISLHQAVCEWIEAQHWVLSTLTDALILLDGGIDYNISHPRGVVVILEALPKTDDLNPALAFKLLGAEVDNHDRYPGLVSGWRDLLGDCREAHKALTKLFESSADLEFDRSTTFVTVFPVMYVVQDTGMMAGHKHILFRRPIQHVPRPDALDDPRTRAALEDVAQLCMYLAGSVEIVLRACEGPCLDGLPDVGRMVRSKSKKTWRWEEVPWDWDAWVLPSTEVSRTSGLSPKQLLTVMDKSTSPEDLDWCKVVAYCSKDCQKAAWPVHKQVCRKATATETGDFDCRDLGYPTPISLHQRLCDWMGVHHWVLVTLLDALILLDGGMDYNLSHQRGAVVILEAIPKTDDLDPARSFKLLGAEVNDQDQYPQLASSWSDLNKVCKDAIKTMTAIFERSGLPAESWPVAVFPAMFVVQDTGMMAGQKHILFRRRLRHVPRPDVLDHPRTREVVEDVAQLCMYLAENEIVLRAAANGPSPQGLPDVGRMIQAPKSKKGWKWESISWNWDTWTIPPTEVLLRSELSLRELVTVFGRSTHTNADFPRSNTHCHKCFKANSKLRCTGCHVVVYCSKECQKGAWPEHKSMCLHEPKANVELQASDLGYPSNLSLSVALNDWIEIQRWSLYTLICALVMLDGGVDAVLASQKAVVLYVIPTHRNEHDGNPGKAFRIGQAVLKDKDGDAFLRKHWTDVWAIKNLCSTNSALAFLHVKQHGDDLFPTPIGSIPVVYYVHRTDMASCDAFTLFHLPLLHVDGNMKDAPVDARALAACEELVYIVKGFLCGGKVVYRHADQPGRVEPVWGIYERTGRRMKKWKWRQLPVHRESEGWRSWERRADEIWPGRASGLTPRQLVTLLDYRGLGTEWWPLCISESDATGSVAVELLPSDLGYPSFLALHHALGEWVEIQRWSLYTLTCALVELEGGPTAVLESQEKVLLLHLVARHRADEECNGGNPAMAFRFGHAVITDKASIQGIRENWAEVQKNVELVAANTAEAFLSSGRTRNPMRIPIGTFPVVYVVHRMGVVRYHAFTLFHLPLRHVRSQDVSDERTRAALEDLVRMMKEALCSILIYRRPEDPRQPEPDWWICEPVGRRRKTWRWRLFPGTEEKWRHREELLERIVPGRTSGLTARQALTLLDYRHVTWVRIFKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAQ9</accession>
    <name>A0A2G8SAQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAQ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAQ9"/>
    <dbReference type="OrthoDB" id="3269282at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="430" mass="46898" checksum="2DB7285847941183" modified="2018-01-31" version="1">MAAVVPRVPSFASLSSAHDSPTHSTDTPRSPKVRFDHDCVVIPDPAPASRLPRLVTKSYTLPLWRRKRDPSQLSESEDEPAEDHVVFKVSVPSITTKARSPSREPSLPPLVSCLVHPDPFSPTRRGRPRRASLPQPMATDAVTVPLRSCCAQCYSSIDKCLSEGDDWQVHFSRGALRRRKSVSDAHTPAHARHCLRDAMPGFDAIVAVDEVDRRRKCTDMDALTAFTIEMPPTSVETSTGPEEIPLRRALSLPDAVYPTRSKFLPDPLPRPLSPSIKEEDEQRLTPRLTPVASPRDSLTDLMATRMMDAANATDLPDPEATPSMKHAPSDDSNSSTDSKLTSSPMSSLTDDDRETISSWFSSPMLAHHERAFSDSPVSSPSSSPVIDHARAPSGLEPSLSRKKPLMGSIFRASTSVLKGFTSMGGVSMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBI3</accession>
    <name>A0A2G8SBI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05815</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBI3"/>
    <dbReference type="OrthoDB" id="2735574at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="501" mass="57079" checksum="986B43C978F957A6" modified="2018-01-31" version="1">MAPVDLWKGELMDRFHAFIFANEQARAPCIYGLTIGAFIYYDLSYANKSDFQTISDRLVAIVKAAVHLQYLDFRTFISDSVFDAMVKLTTLHELHIITDVPTYEEKLLKHLAIFHSPLRSLHIAGNEFSGSNMPASFLHDRLSHLTPTLEFLDLDEFPVDILPSSVTTQFTAVRSLKLRATFAPDCDLLGVLLRLFPKLDNTLELGSLYDSVRGDNVPAFRTRCQEAQERHRWSRLDRLACHADTAYLLALRCPIRRMEIQVRLPDATQYLAETLRYHCPPHLYVSISFNNGFGALDRLFPPEATDKLTHLVVFADIRIRHGRRSIRRNRGDSVHSGDRFVNRLLNSIQDLHLTHLRIVFHYSTYLQARKTAPDADSVGHNPLGDGMDLQATKARFVDAMPTLEYLFLTASSQTYAIPSQKRLWEFSSEILSKWFASKAWRVVHGGEDLHPSESISESDVGIGSSVELSREAAERIMDREELQLSRDEEYEVRLCADPKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBQ3</accession>
    <name>A0A2G8SBQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Importin-9 central HEAT repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBQ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBQ3"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin-9 central HEAT repeats" evidence="2">
        <location>
            <begin position="198"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="886" mass="96855" checksum="7B4A367DA66B1161" modified="2018-01-31" version="1">MQVFAEFIKADLSEDQILPVLRQLLPVLLNILGAPEQHSALTRSRTLSVFCQCVEALYMVKDQFPDAVKEATNSVLPVWLDALKTLLNVNPLQDVENSSNWDGLAIRIQVFKTLNIIHTSFPRALTPHLHDLLNASIHHLSVFYPTFNHYYLQGGAAVPHSSEDETIELIHLVCPMLDFVGRLARSGRARDWFEGENFANLVNLVFSWAQMTQSDEEEWADNANAFVAQESDDSFSYSVRVAGFDLLGVLLERSTIATIKAFQVTIERVIAQSQQQRESGSQDWWRPLEAALAAVGSQGEDMLDAIDDEIDSGRGKPIDIESLLTNVIPSYLVLSQFPFLQGRAFVFASQYAKLLPGQLAVQYLEAAIQVLEASEAGVPVKVSAVKAIHNFCQNMDDAVAVPLAPRIAKDIGPFLPVTSDDTLTLVLETLAAVVEIDDGKWITEDLARAIVVACLDVWMKNNRDPIFISILANVFESLARSPAYQAVVQQALPALTNALTAATDVDSYVASAAFELVAALIQGAPQTGLGDGVFAMLAPALYASLRSTEDRDTIQNGIIALTHIVRKDVNQLIAWSDPATGQSGLDGVLQVIAKQLQGEDESGSLFIGDLIIHLLRRAGEAILPVLPQLLEAMVRRMGSAKTATFLQSLVIPFAFLIHNQRDTVLDLLEGVQADGAPALDVLVRTWCENAETFQGFWPPRISTLALCSLFASERPSLQTLVVKGDIIVKPETKNVPTEFTSVPFPVKALKLLLHDLQSGGEAASMGFSAKDVSEVASDDGDEEWAEEEALHQGFKADEFAFLSDMLGPRGMAFDNDDALEGADDEDLKNDPVSTMDMQACVLPFHSAHLLGFFKECAARNTGRFSAAVQQLTPEEIQVMQKVVGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBR1</accession>
    <name>A0A2G8SBR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBR1"/>
    <dbReference type="OrthoDB" id="2679643at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="296" mass="32719" checksum="10CFE898B58665B5" modified="2018-01-31" version="1">MQAEFFWTGRWTLSRVLFFINRYFSLGVLANTVVAATSVVQAIIVLRICYVYSKNLIARTFVVGTFVACVTSTCAILGVLWHDLEAVPTNLPGLKITTCTAPPSKAVWKLFVPNIVLHTVLYLATTIPALKMRRLGRKSMLMDRLVMDGGIFYFVVFVAAMFSALGALSGTLLVTIPAIYSNILLGLSSVAVSRLMLSIRCLAASLSLQPNWLLNNTELSRVNWKHGPHDGELIVEVEAFERFEMDDMDSPTDKGAQTSFIHVSRVGVPNHPVYPGTRDYKSPPRVKRKKPALAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBU1</accession>
    <name>A0A2G8SBU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBU1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="135" mass="14409" checksum="81E2FDB7CED98A24" modified="2018-01-31" version="1">MESRAFLPEGPLRTDSLNGDSSQQLRNMVWGDDKNGYPFWGLGARIRVRRGSDSSSRQLTSSSLVACGACMLATKGRRALGGPNNCIPPRLGSTTGRVGAGWSIMGSSISESSEPESMPVSELSMSSSRLINTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBU7</accession>
    <name>A0A2G8SBU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_05911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBU7"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="899"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="641"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="586"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="839"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="844"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1008" mass="108778" checksum="17F28992EC05950F" modified="2018-01-31" version="1">MAPSFLSKLVKPSGSHSRHSSANSSPQSTTPSRGPSISVSSTSSSKSVRKHDRRSGNGAAVPPPSINYESEDSSLSGLNVTVIPPSPSVSGSSIPLPSRAPSESGQLSPDNSAEFEGARRRIQSLPAATAPMSNPMPLPTSHHSSDDGLPTPTPATTTFVNMPPAPSSKSLHSSRSSDNMRDRAQSQGSSSSKRNANHPRALTVSEDGRLHPTKELRHQTSNKSLRSKLSIMLPSRDPPPALPSSQPPPSSRHERSISAPQTPPALVESPTGTLQQDIPIIALIPMSSTAPTFSTVNVPGDSDAASIHSVGSAKAKRSPWRRTSNASTPVNASTPGVPRSATVAASPSASAPVPGRGAPRKLTAAGGLSSALAASGLAMAHPAMTIPPIAPSPAETSSVAARGRSSYDRPVTPRSGRSRAGSPANGRAASVYSDAGSFRTEGSDSEGSDESDELDLDPEDIPVTGFAVASNKRNQDFHELFPSVPEGDYLIEDYGCALQREILIQGRLYISENHVCFHANIFGWITDLSIPMYEVISLEKRMTAFVIPNAIQLSTRTAKYTFTSFLSRDTTFDVLHNVWRLARPEDSSMGSQRVSPRGSLEEGDEGSVADTGPVNGVVAPAKKGPARNRITQCECSKSGGHYPETAMDAVFPGTPEKIYNLMFSSGFMKDFMRENQKLLDIQISDWIPTEGSKLLARNMTYIKPLNASIGPKQTRCELRDEMVVCNFEAFVTMLTTTRTPEVPSGGVFSVKTKTCITWASDVASRVLVTTQVEWTGRSFIKGIIEKSCLDGQKTYHVDLEKAMRDYIHEHRAEFVPEGVDVAAVEETAAIVTEVLVPSTPTRLPSEEEARKEREHERNQRSLQWAYDTFEGAFKVAKQSTEGAVELITDAWDQSSSTTILYFVIAFLIISNVWTLTLMGNREEVGRRKEMRKMEEREKWVQGIVTGLWEEMLTSRGTIGAGGGVPPLAPRAPGGDLREEIGAIMTQLDIIEQRISDIRRNLKPLEQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC65</accession>
    <name>A0A2G8SC65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC65"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC65"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="229" mass="25988" checksum="674BBD80D4D1688E" modified="2018-01-31" version="1">MVDMLLDLPPEILLHILSFLDIPDLSSLAKVFPQLSPLVEDPVLNHERLWVVAPSRVSHSLFGTDDAGLPMRPSVPELVHRNIIRGLGIERRWRDGMYFGSSTMVRQYECASRLQWTHARTVLAHSLRIRSSPAARDAFYHARVLPRDASSMHVAAPLVSTVRRLRWAIQRDRLAHFVKDRSEMAKAGGLIKWLESNGRSVMSRENERVRLAVCPGIRGIVKYYEGLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDE8</accession>
    <name>A0A2G8SDE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDE8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDE8"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="10">
        <location>
            <begin position="435"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="857"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="913"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="859"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="931"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL31747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="992" mass="107861" checksum="7B7D39ABE0DEE52A" modified="2018-01-31" version="1">MPVAVDRTRAMTASLVHSSPLKPAHDSLNNDAQTPNPRKRRKAKGKEVEEVEEEAWSWKSLTDSSTSRAPPIFTKDGSYFFSATGPSVKIYFVATGEVVSTLTAPPNSVSCVAGSSQHSDTITAAILDPHNPFQLITGSLDGYIRIWDFLDASLLQTIGISQPIFHLAANDKIRDYVFVAAARPTKQKTNKAGVSTGEDNVAVLRVSLKPKAESAGSAVQMSSEIIAVGKTRSTTGLAVSPSGAWLVATAGHKAYVCQTANLKAGFTKFVSPERLTCLAFHPSEEYFATGDATGCIRLWYCLNESATVKTPGVEKTAQTTTLHWHAHAVSSLAFTANGAYLLSGGEEAVLVIWQLHTGKKEYVPRVGSPIVHISLINTGGEEEYLLSLADASFAFIRASSLKISRSIARIKLDPAISHGRPSTSTSVPLAVHFSSSTLILPSSHPSSLQTFSPSLSKLLSELDISPSNRVSRRDDKPLQPARVERVVLSESGEWMATVDTREGDDVPRPEVYLKIWQWDRKSGFWILNTRIDRPHGPNRLPSVAFRPGVRSRADLLLATVGQDGNIKTWRIRSMKTKSEDVEEFWVARSAVRFRAEIPTHISWSPDGSLLAVSVGSHVAIYEPDSNTLSQVLTCPDCRLHSTVQFLGANGRYLVVNGPQDVLLWDLVSHTLRWRYHSPVVIDQVIGHSGEEQFAVIERAPATTASAPSTRALVFQPSSSVPVFSRTLPFRLRTIVSVPPTGFFPTDPSGFTLVGITEAWNVVVFGDDVQLPEEEGASPQDITQNVGVAKRTLIHDIFGASAFVDLTNPASGPSTVPRTAHTWSAKEVVEIFDAPAHLLPPLESLFDSVMDNFLAARPDEAEEQQEEREDEMDIDEPEEDDDRPVGGGAPLDRVVDRQEMHGFVELFMHHAIKTPSSRPAPPQINGMHKPNGTPSQLNGLHSTPKSGPKAKPNRVLPNGHVYTPSRSLPLSTEGFPATTPVSTAGKKRKKSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE24</accession>
    <name>A0A2G8SE24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE24"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE24"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013782272" description="Phosphatidylinositol-specific phospholipase C X domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="38614" checksum="88423CCDC66D2D9D" modified="2018-01-31" version="1">MRFLQPLATPVVLSLLSSLAGTYAFSATRRATVCNGHAELCDRSFGNVTFVGAHDSYAVGTNSLFVNQDYNITQQLNDGVRMLQSQAHNQSGVIELCHTSCTLQDGGSLKDYLTEVKTWMDANPNDVVSLLIVNSDNVAPSEYDTVFKAAGLDTLAYAPTSASLTASGWPTLGSLIDSGKRLVVFLSTTADFNAVPYLIDEFTNIWETAYDVTDTTFDCNVNRTNGDTSTQMYLINHFLDKIVAGFPAPDPDKANTTNAVSGVGSLGQQVQTCATQHDRNPNFMLVDFYEYGNGSVFQVAATANGVTYSPATPVATPGGSSSSSSGSSVTSTRNEAVDLRIFPAHLVGSLAVAGGVMLGALSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEJ9</accession>
    <name>A0A2G8SEJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEJ9"/>
    <dbReference type="OrthoDB" id="3250108at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="412" mass="45083" checksum="A6AB64170F57181A" modified="2018-01-31" version="1">MLAISPVPEISISLASPEEPVPEPFSPFHQCTFLSDDSDSFRPTLLSPPPLAMTPKQLSPLRPKDAPMTGKGLERERFEALLQAQRERNAALGSKRSPTDLRKEIALKVHKSKQMERRALFLSKVQAPPSPSATLIPVTPPESPAVFHYSLPSPGLDSPLEVFEALTLGHMTASTCQPWVEQVDFRLAGDEYRKVLPRRAPATSVKRKILPSLEQITARLGTNGHVAAPVLEGPSRPSMRLPSFLAPARAEQPQARAPKPEPQQPGTRARAALLAGVGRLRFPSKETAEAPKVEIAQPTPCLPPVSPKSPIAPRLRVTTLVVPRTASASPIELTESNLMAFTAGSRERTAHNMLTRLRRRTLPPQIAVPAPGEIDMEDEIERKSRRHSAPPELPQRNRIGFSHPILELPGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SET4</accession>
    <name>A0A2G8SET4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SET4"/>
    <dbReference type="OrthoDB" id="2814000at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="101" mass="10683" checksum="EEF4C0CD190B5E3E" modified="2018-01-31" version="1">MTDRVFSTLESQIGTGRQMPVNGEPGRAGAEGARRGAMGVTSGVGTAVDNDQMALVTISWTAKPLRIDLNTLFAWFPEPQASADDMSSKVANEPEDPPPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF07</accession>
    <name>A0A2G8SF07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF07"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="279" mass="29298" checksum="28B0B26AF12B66F8" modified="2018-01-31" version="1">MYVPSMDYTRVINGQILTKVFPGTAAEFPNMNMNMKWMNLAAYSIATVVDMVLTGTFVAIMRQCRTGFKGTDAALRLLARYAMFGNLPSDLTRTATRPSPGTVTKTPIMMPAAGSTLAISTFVCSLVLHYSFVYIAISTPVTKGKRPPQSESSLPDDTYCLLPPRGNGSLSSLAPATAPIFCHWPVCTNSVLAVKSLPGPGSLVLDLGVTEGSSNSESTEAVGDVRRAGSGRYPGGARGFGTAEGTSGAASVAAGLAPPDVVIDISRANMAREIEFVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF37</accession>
    <name>A0A2G8SF37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05625</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF37"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF37"/>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="73"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="412" mass="46052" checksum="8D422CDE446BA5BF" modified="2018-01-31" version="1">MSEKSEKSTSFDELMAKFIASKQNTMQAIVEMEEKVEKIKDEIELLEDSCTGEICAVVVAILAAKVDCKLEFQLTYLVTGVTWKPYYDLHGATVDGKPSLDISLHYCANITQNTGEDWNDTILTLSTANSQALHNSTIPKVDPIQDASDDWSLKEEMVTNSIMLDKNPISLSYRVDRRVSLPSERSTHKMSIAVMDFSGALKYVCVPQKTNAVFMEGQMQNTSPYELLAGQVNVFIDNSFATKTEMAHIGSNETFTCMLVIDPSLKVSYQSEFRTVHEPKRNFTEPFKTTTRTVTTTITNGHSFDVTELVVRDAIPLGNDETNIKVALRRPDGLAQAKDDEEVAVALHGSGEARDSEKQGAARVRWVWTEKGDGGEKEGLYEWVCQIKAGKKIRLQAEWEVKAPGDAQWEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFA9</accession>
    <name>A0A2G8SFA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFA9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="138" mass="15305" checksum="97493C94910443A1" modified="2018-01-31" version="1">MYELGAACEAGGDALRRGGGTGSQGKREEKGRRGRDKTRARREHGSRYVYVTPDWRKGSGVEGGEPVLYKQKYQNTGAGGHGREVSWTTNGERGQFIRTEMANYYFEATRVVDDTKGRETRTIGTGGMDYSLTDTIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFD3</accession>
    <name>A0A2G8SFD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05189</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFD3"/>
    <dbReference type="OrthoDB" id="5569250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="261"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="807"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="944" mass="105795" checksum="9A0A5EBA6B112A1E" modified="2018-01-31" version="1">MMDSLPSGELEMSPCISRKSPSLIKSVGTVSLEQFRAQLVQDLAGRAVQAEDIDEFLDRLLPSPGANKRRRRACRGPSKEVNPFAALEDADKMTEADVVRLFGEAVSKHNLAPGMVFSRCDQRPEFNGRSTRRRKKGKNVQPPGEDTSQPKIKRMCQKIDAALFRQKDAPRDGRPHWPDQIVPIEFKSRKKGNIRDPFEDLKAGGDSEEGEEEDEGDAEPQEDEPPELEETSGDDDEDDGDDDDDDPRAPGVDQFESNSYTRKAVRGQLTSYVDLLFSVQQRVSIFMLFIIGRRFRILRWDRAGVIVTPSLDYVDDWKPLCEFLRCVSRLPNDKLGFDPTATRLSSADGEWLEMDDLAVALASDVDSTPRVLNAGELEPEGEEEVEIVFDYQRTLFQKSIVDPRWPRYKLQVHDAPAPRDFLVGKPVFCAHGAIGRGTRGYIAVDCATKRFVWLKDAWRASYNLVEQEGLILQRINAAPGIPGVPTVVCHGDVGKQRTATAAWWEQKNPQPPPNSPSHALSTSRFKKSTKSNASSTSAGKASSRVTQLGAKRKLPEDERARAETPDSETDSEPGFRADCLIRRHKHYRLVVREVCMPLKKFKNGKQLAHIISDCLTTHHLVATVEGLKILHRDITDDNIVIFPKIETSGNIRKLAWKGILADWEISKPITTDGSSRARQPERTGNWQFMSIRLLNRPGPANISDDLESLLLILIYYAVRYLQSTIAHNDDVAAFLDECFDCYTINSGLVLCGERKSSIVSGMGQLLPQLDSTSPISFSFSLDRIISQALTRFCALYKTRRYDNWLESAPVYNPPPSPTPQKPSQTSDTSDKRNILGEASEEERRVAEYEADWNAQPEIARKAPPPAPTAVERSIAAQVKDHFWMKWAFDKALSTDLGWKNAVRHRGGDRVPKGWESPHAVIPVRGRSPGQIVRDTAIAQASRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGS7</accession>
    <name>A0A2G8SGS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YCII-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGS7"/>
    <dbReference type="OrthoDB" id="5519740at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1060">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051807">
        <property type="entry name" value="Sec-metab_biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33606:SF3">
        <property type="entry name" value="PROTEIN YCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14364" checksum="3CAEB08DDD74CA73" modified="2018-01-31" version="1">MPHFIVYAPDYTDEDAPARRLKVREAHLANSAKESRISECPPYLKSCITCSHSCRAELGGAILSPNECLDSPDAERKMAGSFRIVEAGSYAEVRALVESDVYWTGDVWDKEKTFILPWVSAKATPWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIG4</accession>
    <name>A0A2G8SIG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIG4"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="190" mass="20837" checksum="5B190BD48AEF2767" modified="2018-01-31" version="1">MDLPIYYTRAEYIETDTGNKVSRRATISGPQNIILGGKTIIASGAIIRGDLRRTGPGHAVVISLGRYCLIGEGCVMRPPYKTYRGNFNYYPMKIGDHVHIGANSIVEAATIGNHVEIGKNCIIGKFTIIKDCAKIADNTVIPPNTVVPALALFAGSPGRFIEDLPESTPEIVESQTKQYYTRFQPLPQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIJ6</accession>
    <name>A0A2G8SIJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIJ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIJ6"/>
    <dbReference type="OrthoDB" id="10331120at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="236"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="625" mass="70158" checksum="349BB4B3B92AB2F5" modified="2018-01-31" version="1">MWLLRTDNAVLQYFASPEDVPGGYAILSHIWDAEEDTFQYMMKLREEDKAGRTPHNPLSRVREKTRLCCQLARSQGFDYVWIDYCCGDRSHVAELAKDVQSQFLYFSMAQVCYVHLRDVESGCDLHVTSSPFRASKWFESPWSLQELIAPDMVIFYSKEWKVLGTKQNLAPLLQEITAVPATVLTFEEDPASFSVAARMSWASQRRSATRQEEQAYSLLGIMGVSMDVPPYGEGRKAFQRLQEEITKQLADTTVFVWGDKPALSYPEVTRLVRELPPVPAAHTHHSDASFLFAPAPSAFKSGFVKARSMPRLPIGNTTYTLDTTNLLTFTVTSNGVLAQLPVIELSQQRILIAFISCSMDNKPLGLVLERCPNASAGVPLYDVGINPPNSPGTFRLVTLDDVTTSGAEGEEATFTWRTICIRGRHDHDPSEDFQRVPMNRDLSSFYLRRDLLTKFGGRYLRRDVVASMAPMEQAKPSSKPPAQDASPAGTSRIEELFPATQDPLAATKESLPATFLFFAEDKPRRLPFLVHFGRCTVTNGSSSGEDGAHWANVERYDRYDAERVESWASIPTHACPADHISGWEHQEKTFPMPFEPFTYGIRLSFSAAFGTTQVLVPDIVTLYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIK6</accession>
    <name>A0A2G8SIK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIK6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="147" mass="15965" checksum="FAAB0AF370AC1B4B" modified="2018-01-31" version="1">MTNPQKQGRPLSAGEFSHNVTSSLAGPPPRYSSALAPTSPPPPMASLFSRAFKRKRRDTELDRARERLARELRAMESLLAHWHDRETSSEASKTGTSGLSRAGALQVTQAEIDPLTVLSSGMVDAGSGEEALPRYEDLEPRHGQDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIK8</accession>
    <name>A0A2G8SIK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIK8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIK8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="122" mass="12523" checksum="AB4D5FCFE1440F56" modified="2018-01-31" version="1">MHGPRGEPPSSMFYGQHPQFNIPPYGGDPFGQPMFPVAYNPYPSGPSPIFGPPGAVQTPAMLGEGLGAPLEYPGMPGMPGMPGMPGMPGMPGMPGMPGMSEYRIGADGIGLSGFELLTMLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIZ7</accession>
    <name>A0A2G8SIZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIZ7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="239" mass="25413" checksum="3ED7EB050109D2CC" modified="2018-01-31" version="1">MAGSQLLKAAAPTSADSSAAAFSSSALDVAVNPKSPSYDEIIASDAAPYPASKPPVQSPSTQHWNPRSLASRAVVVTQHSVVTPTTSRCVTPRAISLRWRLELQNAPLPGLSTTTSPGRGRSSSTMSCPCCPRTSSRPMGPCSPMPSVWCPAGAASWRSRLAALRSARSGRWPSRVWTTCRPRVRAAARTAAAAGTTERTPAKTAGLPHWMAPKPPGSTKSRWMSIRRRAVRRRGKVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJM4</accession>
    <name>A0A2G8SJM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJM4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJM4"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013802479" description="NmrA-like domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL33972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="359" mass="40521" checksum="54583AAD44F552CE" modified="2018-01-31" version="1">MSSHKKLILVVGATGAQGLAVVDALLQPQADGSPSPYAVRALTRYPDHARAQELARKGVEVVKGSVQDFGSIAQALKGVYGVFVNTDTWTLSEAQEVFVGLRVFELAKEAGTVRHYVWSGLDNIFKKGNYNPKFYAAHYTAKSRVADWMKAQESVVANDKLSWSVLTTGPYMDMLNIDVFGPIKQRDDGTYVFASPIRSGHVPMIALEDLGFFARYIFDHRAETSGRELEVASDYVGWEYLVETFRKVTGKKAEWLPLTTEQWMALFKHTDVPVHADEQGKPGAMTFKQSFSRWWEIYAEDVVRRDMEMLRRIHPGLLSVEQWMRKHKYEGEWQTGMLKGRGPEGETGFVPDFEAIGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJU8</accession>
    <name>A0A2G8SJU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJU8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="132" mass="14946" checksum="5AA0B15B22E6A756" modified="2018-01-31" version="1">MAMIPPTFTCLVSIPRNDIRKDHKGEISHTARLPSLKKESEMTTTSEHNEESSKTKRQINRRAAYGSASLSLAALSLSSWPRTANAQRPGSRERERLRVRLLWTLKGRSVDVGVRRLSTSMSRSSGIRTRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKY4</accession>
    <name>A0A2G8SKY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKY4"/>
    <dbReference type="OrthoDB" id="10626400at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="931" mass="97110" checksum="5E474D6F99D1E13D" modified="2018-01-31" version="1">MPIKRVTRASTRAARATAANPAPANPPAPAPIPVLANIPQGGALNGPSPRRTRSGKILGMVKSVATKLSRPRRAPKIAPIQEAVGEVAGNIDVVPTTDPATVPQPPPPPRKRGGKAAKKDENEVQISADDVAASTPSELAPIPLPVPVKRTIGRTKSTRSLASKDKGKARELPIEDDQAPQPQPIVVPVPDPVPTAPPTPKSPKPIEDIERVIAELRILNSTLLADDQIHYLDHVWKSCVNGDTRLKYLNTSKEAERLVHEARAMRQQSTRGRAAAPNGGTTRGGASSQGRVGGQLPPQPPAASTSNGAGPSHGAGSSNGAGPSNGAGPSNGADRSEPIPKPSPLKREYAINWGHPEYYREKIRKIKEAGTPLAPADLDRPAADAAPVASTSSTVPSASTSRPPTANGAAPSGNGNGNAVATDESDAPLVMPPIRRWNAVILGYPEGYTPRNPWPASMIDPTGRSTHPDAVQDASGTWVIPRNSSSSVALTATHAVPPRHRAAPPQNRAAPPQNRTAPPVTPITAPVSRSPPPSSSSNESADIDEVEASISIDVDEGDVHPAADLLPSTAQLPSSSNAPAAAPPRPATPARAQVSLDRQGREIARHQHYDEDAVVQQVVDHVLSEIAAERAARPVPSASASASASHSSRSTRPMDPPPPQPAASTSRRVPAIVWPEHDKPGTEEGINLFRQAAKGNLKRQGSSSLASLFGSSNAKGKGKAVATGQGQANGRPPTTIFGPPQGKRASLQRENQNQNQNQNRRPPTTIFGPPPQDKKGKKRARESEAEDEAEAEGETEAETEAAPETGAKAGPVVPLWGYTSSTGPMKVRVSLVPIVPSPKRQRVSESEAGGDIDTAPAESQPVAPVVGGNQGESAPALSEDQALPASTQRCNGAAKRSRTEFEESSSSADADLEGEDEDETRPAKKPRTGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLF0</accession>
    <name>A0A2G8SLF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLF0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLF0"/>
    <dbReference type="OrthoDB" id="3354175at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="207" mass="22614" checksum="B54A19EF7F896A0B" modified="2018-01-31" version="1">MDHIQSRPPHLEQASSGYDDDGDDGVRPKDRDQGVRVIFDKSIASWGEAFFTLSLTTNLLATFLIAGRIIWMNRRVKTYRMAAGISHWDIVETLVQSAAIYSAALASLLGTYLAGSNAQYVCLDLLNPLIGVVFTLIIIRVGLGETMSEVSGKQTSDFHGQTIGGTDFNLRPVAINVSVTQAHDRPSLEIDRKDNAMNDLESGTSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM32</accession>
    <name>A0A2G8SM32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM32"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM32"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF24">
        <property type="entry name" value="3-PHYTASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="635" mass="68783" checksum="44548174EE426C8A" modified="2018-01-31" version="1">MRIAQPSDKYLLPHIACNPPSPPPASATHRIPMPRASSKAKSKSLPPLPIVAAHIGSSSAAPQAPHGSSPSPDGNPADAPGSAASTRRPRACVTNGCIRTTVTLLVFGAYLVWTWPWHRAHGFEDIPWLLCGRGDAPHSHIWTGTGAGTGAGAGAQVAAGVDMDVDVEGEMGEMGEMGFGGTELGVPASLQAKWGQYAPYRAQGAYVGPPEGCRVTQVNILQRHGARYPNLKEGEQYARAVRRLGSAKEYKDKRLRFLRDYEYDLDADNLTPFGAAQTFESGQLAFTRYRHLVDDGNVPFVRASGAQRVVDSAGNWSVGFAAASRQRVQPYLNVVLPEDANSTLKQDCPRAADGSAQMDTWLAVFAPRLLKRLAAAAPGVELNARMVFDVMAMCPFEAVAKKRAAGPFCALFSEEEWRDFEYHGDVEKYYKDGYGNALGAVQGVGYVNELLARLTDTPVRDNTTHDPKRAFPLGRALYADFTHENVMVPVFAALGLFNVSRALDPRVRPGYLEHLGEGAGLGAGPRHPRFAANEKEGDGAKEGEEGEEEEGQRWIASQMVPFSARMVTERLACARVWDGGDPEAGEYVRILVNDAVQPLAFCGAGERGMCRLEDFVESQGYARRSGDGDFERCYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMD0</accession>
    <name>A0A2G8SMD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMD0"/>
    <dbReference type="OrthoDB" id="10679631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="872" mass="94318" checksum="5D3C9ADD4DD5ABF3" modified="2018-01-31" version="1">MRLTRPRSNSKPSTRGHSSHKISLRRHRNDVLVPHSFIRSCVSCRRRFVPRGPTSSIRFKERPTTPVSPTLDQAEQDAMTHDGDVDGEPGPWDSPREEPEASVEDAMAAPHDYEDSRDAEAERMAYASPPLSLIPFNFSECSPLAGVEDESSLRDDSPADSLPLPPSSIPHDHPAYPGTGAGDATDAQSPCNEVVVKQEEDEEDAMPPPAHIRMEHSLEPATPRQCDVWRRALITFPGQEAEEDRLYTTFEYAVPPGQRRPGDDIAETLSAARSGGLTDLTLYFGCPGFQCEDDHKHREWRRAVIIRIVRRLGDVLGSRLSVLQVTGPWPELIFPGVPDILGIVLDSFPALCRLHFADLQCECGVCELQYTDPARFKRLQLFALEHRISTPLRWIKSSRVTIEGKSFYSLDKDFTAYIGDDARLAGSVRNLCSTVSPNEGRAGASARAQDEAQFFVKLLKRDLPSATHFQVITPELRVEYVRDLPLCRIPSIPRARTSRSPAGTPYRHSLTPNPTSASRTRTPVYRESSSASSCTASASGYTPPPDAGVAAPVDDPPADLSGDICLQDDLSDELGLDSETGSGDLGPQSDDDFALDYDSEGLDSAGTQPQGVSDARATLGSGGAFDGPIMDADVDWHAVFMAEQDSRSDGGHDLQLGDGGIATEPPIPSLLSPIPSTWLRASTFGDEEVSVAGASSNSNFTPSDQAYHPIHFFAPGGFAWGGSDVELEVAGTDTTRIGVFGIPSALFRPENSADRVSEASRPEAADAGGLTWAQHAALTPTMHTLPDDVITELSESPAVGDLEDLQPWRYLEDSPSASIPSDESYFESGQGSGSHLNVNVGVQEVDGHGGLGPQLEGDMDMSDFDAETPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMU8</accession>
    <name>A0A2G8SMU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMU8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="171" mass="18061" checksum="BD00202E757A6B38" modified="2018-01-31" version="1">MSLRATSGVSAEEETISPKLLITMVGCILAFLVIVIGFFLVSRKKRGAPSFPAPSGPALPLAHNHHHPIRRGVATPVASPTKCPACSESKPSGKRLESARASYESLRSLTPLPLYTRYAPTGVSAIRPETWRSQAASAASPTAPTMLPCPSTPPPAYARRGPTASVRCAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMZ5</accession>
    <name>A0A2G8SMZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_02920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMZ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMZ5"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="304"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="359"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL35131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="462" mass="50671" checksum="F190DE193315EFC4" modified="2018-01-31" version="1">MSTAAAAAMPDLTGCTVDGRFRLTRMLGSGTYGVVYEAIDTHASSAGAPATRAIKITRKADRKKHELAAARREIALHGLVSNHPNVVTVHDAYEDDNYFYLVMDFCTGGDLFEPICRQVYVGNDALVRRAFLSLIDAVEACHSLRIYHRDLKPENILVSDDRSQVFLADFGLATNQPIVQEFYCGTAAYMSPECIGHLSGFRPYYTAFSDIWSLGVILVNMISGRNPWEKATLTDPCFVQYVENPDFLFDALAISEGVNDILRHIFLLNPLARLSLQQLRLAILRLDTFFRQEDELSVVESYARAPAPQEQQQQRAAPAAAPSRPVTACRPSNVVSPQPHCDAHASRPPSPHSPTVQRPPGLSSLPSLGGEGRSTGSQSTVGSSGSGASSQEDSMVVTPENSAVGVVVRSNLNEEEEEAQEEARRIAGADSHRIRLEDTKVPVAEFLFPRLDMNVRHDHDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN26</accession>
    <name>A0A2G8SN26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN26"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="165" mass="17231" checksum="B61BA5774ADB2FFE" modified="2018-01-31" version="1">MTTCTILVQREGAVCPRPPRHPRSGRRTLSGVANCSIRYLRARVPLFGFAFSLGIALARTPSSVLSPLVRARALSLSTASNLANSVFGACSYARAGVSFVVHARDADCQSESAHNVTTRAGHGAVVVAGGIGDGLRGLACVKGVDAHDREFMKKGIWAVGTAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN60</accession>
    <name>A0A2G8SN60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN60"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN60"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="50133" checksum="A20A8F48EE77978D" modified="2018-01-31" version="1">MSTSDQSTVLGVVVLARHGDRQGFYQDPETYTASQTAITPLGETQEFELGSVIRDLYFDPSSPSFVQGIANTSALFQQSQVAVRADAGGEGGVIFDSAVALTQGLWPPTFRASTVLANGTNVTSPLSGYQYIPIESVEPNEDVSLEGFTSCNTFDAHTTAFYNSDEFKAKNAEASQFLTSLQPYMDGRPVTLENMWNIFDYMNVQSIHNATFANTLPNGYLNQTRDLANWHEYNVFSDSAFDGIGNVAFRTMIPSVVTALQRIANSTDPLKFHYSAIAYKPFLSLFNMTGVVADGALPPAIVNYAASVVLEVRQPSSGSSPVVRFTFKNGTDDATYRTYPMRFTGWDGSSSSADAPLATFVQAFAPAGINTTLEWCNACAQTQLRGCAALYAGNGTAGASVAGVRHERISPVGAGFLGAGLTVAVFGIVAAVLVFLGLLTLGRGKRRAGKKVREESHSSTNSMTKESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNJ1</accession>
    <name>A0A2G8SNJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNJ1"/>
    <dbReference type="OrthoDB" id="2752977at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="63702" checksum="E6A1326BA1EE517F" modified="2018-01-31" version="1">MGTSHSVHTSLARPSGLNPVHWKPHWPRHYASKARLPVTQHAHPALFCYDVLVEIFTAFDLDDRDDLTACARSAQVCWAWTDPASQALWTSCGGRSLKDLYHLLRAVDVSLISEVLSLNTSAFHHRHDGWALFLYCGSQIRALKCSDHDWRDDPAAAKGAEGVLIRSLVHRNHGRTFLPSLRSAEWHEYPETRGALFSLVPPSLGSLNLTLHSTMTQHDIETFMNRLSSTVPGLHTLRLTTAPRVSVERLSYPPHLRHLFLDANRIALSPAELTTLVSCLKTVETLAVRISEDRAWHDAVHFGTALRVLRIEGGCLDLAALVSRLHSPSLHELDIRVKEGCEYSSYYPKGHHQLATALGRNMRLARTLRSLSLRYSTSWCPGSLGFTGPPVMLFSSILEPLLHGLTTRLETLEVEYWHRAVQFADDEVLQLAQACPELRRLTLSLGARTMCLQPPTVLPSLVALRHIAQHCPRMTHLEIELELAQDRYHSGLLAGELDGLCSPLRADGTLGHPLQTLELTIRMLVGSRDSDDDHEVGAREEVQRYANRVFPSRYRDKEIVFVSGLDSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPA1</accession>
    <name>A0A2G8SPA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPA1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPA1"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="72"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="235" mass="26472" checksum="3BC9CFFF1161909E" modified="2018-01-31" version="1">MTRVPVWSTTSAESVFSKPRPLLHKTCARPGPPLTLRQLHRPLSHRSSLRSFPRFPSPRRSTSSSRTFFTTPPAMSDAGFYSLKATAPGNKPYEFDQLKGKVVLIVNTASKCGFTPQYKGLEALYKKYKDQNFVILGFPCNQFGGQEPENDEKIAEFCELNHGVTFPLMAKSDVNGDNTNEVYKWLKSQKSGLLGLTRIKWNFEKFLIDREGQVVHRWASTTSPEAIDAEVAKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPK2</accession>
    <name>A0A2G8SPK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPK2"/>
    <dbReference type="OrthoDB" id="2755316at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="122"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="331" mass="36511" checksum="9A0C9C58747E9656" modified="2018-01-31" version="1">MFLRVMVFAVWTLDAVNLFLFSATMWVYLVGKQLSFDNEPLPWMSNGQIVVNAVAIAIIQSFYTYRIWTLTNYKPLTIIVMVFVVADLGLGLLLFMKSVSTPSLAEFISLIPFDIALSTVTTVTDVLLCGTLVTLLAMSRTGSVGADRLINRLLFYTINTGLVTSVCSVASLITVLAIPEAAVYVMCYYIGSRMYTVSLLATLNVREGLRLHAERLGQGSLRGLTRSSNSGSRRSARGVADAMVPTKEIVVAIQRDTTVTFDDRSDSDHKHDTHRRSYRCHPQSPTSSRSQFVGLLSTVSSKLQRPGGSSRELDSEFGPPPRSFRGERYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPV3</accession>
    <name>A0A2G8SPV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_02473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SPV3"/>
    <dbReference type="OrthoDB" id="21225at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="982"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1508"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1387"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1456"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1387"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1417"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1475"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL35743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1636" mass="178364" checksum="FCB24466C4DE5632" modified="2018-01-31" version="1">MDTRMPPSFLRSEQIVPDLPPIQSTDDLPYSLALANPPTILLSTISRLAPPSKTPRLKRRPSTASSAKDKHDLLPPAPSPGDSSSTVHLSVVDVTGGNKVASSDPGDPRSAPYEDSTLEEMNRKAHAAVAGLRAEASRLAGVEVLPSPFDSSPDEIDHLSQSASTVRDTDVVEPDYDWATFIHAYSVGRWDPLKTPLPPRSHLHAPSLPRSTPLDTSVGSICSDIMFDSPQLDSVPEWRPAETPSEAPSSRSALAGDFDSSASSPPEQRSGQPASEPNGAPSHPSSAAQPSSPWLALTETAAGPSKPLKSPSIPLNLGPLSHRLRNSFADMRTTAVHQSQSHLEHSRCPIAPADATATAAAIRLAAARVSVAPLALPSPEHELTDPLRGVTATIPGSHPDVFAHAEHLPLMSPNTTRKTRLSSFWQGTQDVDESVALPYSPSTDPDSPTLDDMADGMVDGGSLAPKEDAEPQSESRHSSGSHSFMSTLPPATAPALTVPEQPDDDYFGGIEPSRYHGPTVHPDHPPVPPVPRLVADISRQASAPPFDPAPQSVPALPRRICLTRQTSAPLPTASLYERRSRSARLASESQVNSLAGRAAKEEQMFSELGYLAPPNPPNELERRRALYKYNIWGTGPDPNFDRIAHLVKLVFNTRIVIVSLIDATEQFLKSESGMGCFSMPRTSSLCAHAILQRDDEPMVILDAQEDWRFARNPLVIGHPHVRFYAGCPLRTQEGFNIGTLAVMDDAPRREFSPRQRHTLKEFAQVAMRELELWKDKIQLRIRDRIQSSMEQFTRECLEVDKHANEENSEVRPPASTSMEQIYIRAAKLVKRTLDVEGAIVMDVSHVDVLETVGAESSMSLTLHDADGGSESQSRSLSKEQHRKLAEFFESYPEGKICEGIVHASLRPFLPARIQYVLAVPIYNIDKRPFALLCAYSTGERTTPFLEGHELSYLRAIGVIILSAVLKRRMILADKAKSLFISNISHELRTPLHGILASAELLAETSLNHSQASFLQTVQACGTSLVETVNHVLDFTKLSGNAKAGGVENVIHLSRVNLMQLVEEATEGCWIGHRARMFTSEIGSVYSPPRHQHTASIPNRNKHVETVIDVGHCESGWTLRCEKGGIRRVLMNLFGNSLKFTSDGYVHVMLRQLPNSGDTPPGKVKIELSVVDTGKGISQHFLKNQLFHPFSQENPLQTGTGLGLAIVNSIVRSPSVGGKVDVWSAEGVGTEIKVTFTAEPVENANEPSSQRADFAKIFDDAHRPTISFLSFDETVRGVELLQRVLTHYLVTDWQFPLAEEGKRGDIVVVNEDPTPVTLAIGSKDASRPFIILSSARGDPRLMAIVNEYEHIGGFCRIVYKPVGPRRLITALKLSLHALNIGKSSHTITASGQILRPGSSSRPSPFEHADPASSVLSRRNSEETAGEHPTLKLSPQRPSLGPRAITAHPLTSWSHLPATTEQEEPESDSPPNSPRMSQTPSSQSPTVSVGTGGTLLKSSIGTVEPQGPLRVLVVEDNSILRNLLVKWLRNMGYEYREAVDGQEGVQIFETGGYFDVVLLDLSMPILDGVGATARMREIESMRRQENRFGSQPTRILALTGMSSLEDKRRAFEAGVDGYLVKPVAFKTLDSMFQKLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ10</accession>
    <name>A0A2G8SQ10_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere replication protein EST3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ10"/>
    <dbReference type="OrthoDB" id="3144405at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33164" checksum="2D52E204F0F90A16" modified="2018-01-31" version="1">MADSIPSPWIVDYLIDIAEEYGANLSAAPRKEKAMKAQLVRFLTFPPSGDEPCSLWVEISDKKHIIRARLSVDAISKFEKNPIHGGRSITSHRSAFVSLKRFRPALGRVARRDGHPGLTEESTLFLDVDEIVLKGAFGEPMWGSPAEVVSDDPRIREWIHGLRQDGGAGNVLKLRKQEAMARAAEREAFETRAALKPPVKPPIQTTINSAALDTKAKSDGVALSAAAQIKCPVFKRQAENSNPLTLRFSRDVEVFMSLPFSLAGATDPQFSSTNPAVFVTSTISFELVSFRKGDSSAPPCPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ48</accession>
    <name>A0A2G8SQ48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_02428</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ48"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ48"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL35698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="544" mass="62080" checksum="9DAB2070A5EE1DC5" modified="2018-01-31" version="1">MSANATFSEPWTGTLTQFEWPATPRLLLLALINVPVLSIILNVLWQLIPGPKSQPPMVWHWIPFLGSAPSYGRDPIGFFRECREKYGNCFTFILLGKRVTVTLGTHGNDYVLGGKHTQLAAEDVYSHLTTPIFGKDVVYDCPNEKLMEQKKFVKVSLTIDKFRSYVGMIEDEVKDYLNSDTSFRAYQMDDINEWGAFPVLKTFAEVTILTASRTLQGREIRERLTKDYAQVYSDLDHGFTPLHWMIPGLPLPSYRKRDAAHLKMSNFYQSLIRARRSLAEHEREDDVMNSLMQQKYRDGTPLPDHEIAHILIALLMAGQHTSSSSLAWTMLHLADRQDLQDALYKEQVAYFGTPDGGLRDVRYEDIRELKVLDAVVRETLRVHPPIHSIMRKAHVDIPVPATLAAPSEDVRFVVPKGDIVLASPIVSQLDPAVWEDSDTWEPLRWYDEKGVAAQAHKQYNEGEQVDFGFGLVSKGTVSPYLPFGAGRHRCIGEQFAYLQISTVIIALIRRLEFRIEGEFPKADYASMMVQPMPSQIMYRRRKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQD6</accession>
    <name>A0A2G8SQD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQD6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQD6"/>
    <dbReference type="OrthoDB" id="2795925at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="348" mass="38350" checksum="8EFB6CA7A5CFB7CD" modified="2018-01-31" version="1">MAPGRKAGGAKTEQCPHCKQFFAPGGSFTNHKRACEKAKARGESASRLATQFAQVNDPLQGIAGVPPEERHQHGPGHGVHVLHVASDVLNAAVPQPDAFAMPVAHDGYDGNAPPPAGDRVDPPVLHPASLPPFPLFPAPNGLRPPSGGFVVDDFVTVTHPSANVPIAHARFEDFNRSLPDVDPAKLSSKSWAPAFQSLEEFQFAELALELGMNKEQVDRFLALIDVVRQGATFTLKKHGDVMNAWDRASDIHPDFKSTDITVPYLREERTFTIFYRPLFDWGLKLAEDPILAPKFVWNAQRLYKFDGSKWIRHDSLLLEGKRAIQSLYDLQTCQQRSATARVMVVGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR78</accession>
    <name>A0A2G8SR78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR78"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR78"/>
    <dbReference type="OrthoDB" id="3249498at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052055">
        <property type="entry name" value="Hepadnavirus_pol/RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33050:SF7">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47096" checksum="7498FE2FCFCEF782" modified="2018-01-31" version="1">MYSMPIHVVPKPHSDKLRLINNLSAGRYSLNGMIRPESIKGAVLDGLPALGSELRKLRRDHPTEDLILWKSDVSQAYRRMPMSPYWQIFQVVTIDGQRHVDRCNTFGGRASLRIWLAFYCLLRRFVEWYLRYGMYIPRDQARLLRLWDDLGLAHDRPKQEHDLRLAWIGFEIDANSSYATLPENARLKLLAALDDFCGPSRGRRRTLAEFQSLAGYVNWALNVFPLLRPALSNLYHKIADKHERFATIHVNKAVRTELTWMAAHVRSLPGIRILSQSVWSPADLTPNSIHDEFALVDASGIGLGLYFPWHHLGFFCPTPDNIPTNGIFFPEALAICSAIHKLTAWRSIGRHIKRIAILSDNTNAVSIFQSLRADPAYNPILMSAVDVLLTNESEHRVDHIPGPGLTYISLLSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRH9</accession>
    <name>A0A2G8SRH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_00064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRH9"/>
    <dbReference type="OrthoDB" id="2721240at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013614235" description="GH18 domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="44"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL36376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="222" mass="23186" checksum="CFF33E87201152BC" modified="2018-01-31" version="1">MFSSTRMITAVFAALALASTGFAAPAPADGDVSSISARAVAPTSRFVIYSDNWVTGALPAASALKGYNVVALSFLTLNGAVDQAGNWATLSAADKTAKKTEYHNAGIKIIASAFGATDTPTTSGANAVNAANTMAQWVKTNGLDGIDVDYEDLGAMNRGDGAAEKWVSDFTTTLRKTLPQGQYILSHAPLAPWLAPNHQFAAGAYVKINQNVGSLIDWVRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRW0</accession>
    <name>A0A2G8SRW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRW0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRW0"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="506" mass="55820" checksum="0D548E72DD1DAB5F" modified="2018-01-31" version="1">MAHCRPHPNLTRLAIDLNFILSTRLSPRALIPFQARSKSTSTYLDQITRKLNFVCGELDLDTGEERDSSSATGAVSKSLQDELNLPSQPQLKLSTHYISSFPRPTKRPNHIPQALLSSLDTTVRDSPRNFFLPDSTHTSRDWKDMPAIFLPFRHEDPPDTVNESVPKHIREGYADLLPDHPAFDAVFARQVKRGNYEAVFAMYSSMMEHHTPTARPDARAFIAVFDAIRRTTLSSRSSPRRLGIETPRNTPSPRAVLKDMLACLERRILACQNRNDAALHAALQTFMAQRDYAAALTAVRLCRTFHFSLPTLAAYRTVVNPLAERIQAHPPPDSSSNTSNSQLEAIFASRFFGLHDRAAAGTHAQPGPAHASPRRVGRLDPTVIARVLAAGLVSPLELDYIPVPKFDPGTGEALFPHTPGCVGLPSPLALARELRALEQILDRAVLASLPKLGRTPAYRQMQASAVVEAAEAEMHPRCDPSMRGMLGSEHRGANFSLLSALAQVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRY9</accession>
    <name>A0A2G8SRY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRY9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRY9"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="864"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="899"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1121"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1197"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1218" mass="133258" checksum="1D0CD8EFBAB6B076" modified="2018-01-31" version="1">MIPKVANHLFHHTHRAVVAVQNQTGHTLRNVLQLQSSSGSSSAVTGWGSSVSSGSGHSGAGPSKFHAGGRLHTLQPGTPVTSTQVRERVDKLSAFRVPSSQRSQHVTSEAASDSSQLVRSGFGTYATLITNLTDRDFENHEAVRRAEARLRRRRRAAVDEGLEEEEKRIASLRGDSNFKSALALFHTAAANPNSKFPLQVYNKLLRSCAIHANADAAFAVYSHLENRLDIIPDAQTYISLIETYANRHDMQGAESMFGKFKDAASSDGVYWSIDAMAAPSAVEELQYHQRAAQTAVWNEMLAAYFRCGQATEAIGLLEQMMDAPAADSFVPTGVPLPTSATFARAVTGFCQAGDVSTALAWFERMLQQESSSSDPHATTRVPHRPDASAWTTMFDTLADEGMVAEANRLFVRWQAIASQEGAAIWSDHRDSVLAANLKLMDTRADLDSAKAHELLGFLADHVLPWDIENGHFTFYRDTSRSLCQRLVMQYWNLGYTDEALDLAARIATRQLEVIRHGQAVRKFDAAQSQRRIEGTRRFAADLTSGILRQLGSSAPLSHVLRLSALLTDVGALVPAGLSESCLNAYALQRSSSTLALRTKDWEALLDIITADADSAAALNTLVDDLLHYSVDITAFSDNAKNHLVRSLASHDVNSATLLAQLGEPFTTRLLELQRAMESSSPVSAHSFEAQLPVEEIPGTPLMSAYSSGRIDTAHSQHVGEFYPGGGKTSVLTAFKRFRSGADRGIFPRPIVLSRLISALGRLGEVDKIHEVYDGAQVVLNSLESMKQWQTSGWFLIEDHMIIGLAHAGDIEGAHAHRHRILQQGGVPSADAYGALILHVKDTTDDTSNAMALFTESQNLGVAPNIFMYNTVISKLAKARKADFALQLFQDMKTQNIQPTSVTYGAVIAACCRVGDAASAELLFQEMTSEPTFKPRVPPYNTMMQLYTHTKPDRSRVLHYYNELLAANVQPTAHTYKLLIDAYGSIEPIDIHAMDKVFEDLLADPSVSVQGTHWAALINAWGCVQKDLDKAIAIFDSIPTHAVMGKNGSSMPDAVVYEAMINTLVTLRRMDLVPEFLKRLESSGVHMTAYIANLLIKGYASVNEIERSREVFESLLDPQEGVAAPHNHAPHQNKQSNILPVPAGTPVYREPSTWEAMVRAELGNGERDRTVALLQRLQARMFPPAVYQRISGIMLDDSVSPWSQSQSDASSSSPSASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS44</accession>
    <name>A0A2G8SS44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED10</name>
        <name evidence="8" type="ORF">GSI_00269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS44"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS44"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="208" mass="22582" checksum="A1C9A237F743084B" modified="2018-01-31" version="1">MARNIMSTPTSVAPPVPQAPDSPRESESPPPPGLQGDLEIELLNLAQKLYDLGITVVSDLTKEKDKPGNGKNVGTRVNHVIESLGMLEKMSDSITTTVPLQVLVDIDNSRNPMLLTKERLERAATENQFMNGKIHAIEFQRAPGNGWVPWSYRRMLDEALVQNFPDLGEHLMESAMLTATGAHGLPVEEVQDGMPGPSGHVNGFPNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS60</accession>
    <name>A0A2G8SS60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS60"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS60"/>
    <dbReference type="OrthoDB" id="2748837at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="17258" checksum="153CD2F2062337E1" modified="2018-01-31" version="1">MLQHIKLNKAHTGAYLRVKLIKSLKSYGIEKKIMVVMCNNVANNKTMLKEMHILMPEFQDNEMHVCCFEYVLNLVKDPKWGLHLYWFIMLENERDVLKDLHHLLNLFLFTTNQISSNQHALIQDVILFINIFTEHVEKFKTHHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST69</accession>
    <name>A0A2G8ST69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_00658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST69"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST69"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03141">
        <property type="entry name" value="GATase1_Hsp31_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="78"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="225" mass="23483" checksum="321537448C7701F3" modified="2018-01-31" version="1">MPKRILFVFTSADKTLLGAPTGWYLPEAAHPYYVLAAKYDIDFAAPAGPNPPVDAGSVAAFQADVPKFLEDPAVKAKLASAKKLSDVKVADYDAVFYPGGHGPVLDLATDLVNVKLASDFFRAGKVTAAVCHGPAALVGATDANGDSIFKGRRATAFSDAEEEAVNKVKDVPFLVEARIKELGGTYEKAAELWGATVVVDGVLITGQNPASAHPIGEAIDKALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STG0</accession>
    <name>A0A2G8STG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_00747</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STG0"/>
    <dbReference type="STRING" id="1077348.A0A2G8STG0"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="9">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="334"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL37055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="482" mass="52205" checksum="13ADB97E8A3D7570" modified="2018-01-31" version="1">MVGVLGESGPVIPHAETSAAAQQRQSPVCVTCRANSAIYTCPRCNLRTCSLPCSTKHKTLGDGCSGIRNKAAYVPMNQYGYMALMNDYTFLEEIGRKVGEVGRQIVQGGYATSTGGPGGRGGRDPRGRGRGRGRGRGGAHGKASSKRDVLKIQLDFRDIEIELLPNGMEKRTLNQSTWDFKNKTALLTVEFTFHPPQSVLAPPGQPPDPPFTLVAHRIALETPLLTALQTHVAERNKSKKEKGVPQWVLALALPDEDIPDSFTPPLCVMSTPLDPLAALHANPHIPQPGRILREGFYKLDANKTLGTVLKHKHFVEFPTIDVWEEDGFHGTIVDDKGTVVRNPGDEHRPKRRKPNPKQTAKAMGGLLAGYGSDDDGSDVESSSTQNGMNLLGDYADSDEERDTTAATAFDINAEEWGDDDAEGETDEEYEGGPEELAAMLQKLREAGALRDPGNDGTLGGLGVLDEEQVDWGESGDEEENES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STZ4</accession>
    <name>A0A2G8STZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STZ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8STZ4"/>
    <dbReference type="OrthoDB" id="1894652at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22209">
        <property type="entry name" value="EMC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21203">
        <property type="entry name" value="ECM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013923545" evidence="1">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="238" mass="25481" checksum="D6B59498D483BBD0" modified="2018-01-31" version="1">MFSPPVLLLLAVPPLVSASPPLRLHHRVFHPSLPDSPYSERAILHVSGSGPAAETRLVPSQTYAENLRDFFSAVEGLKDALYQVALERPGDIDQTQWATSSVLACHLPSSTSEAFTIHLDQHGAPFTLDYFLGPVPHDGACPKPIGRKASASAGSSPAQLRPIANTTVALRSPTFPPLPALRVPPPVSAEGKPIEQPREKSFIEKYWMYMVIAVIAMSLAPAPAEEGEARGQGSGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STZ9</accession>
    <name>A0A2G8STZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="11">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_00949</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STZ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8STZ9"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="13">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL37256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="221" mass="25083" checksum="7E24591CFDA4E81A" modified="2018-01-31" version="1">MQTIRLARAGWASFRQSGRDHLNKQPRLRWFLSALVWLPLGLFVTEYGFNVKSVKGRSMQPTLNPDDSPWRDIVLFDRFSVKLRKKYERGDVVALKSPADSKLVVKRIIALEGDVVRTLPPYPDAEVRVPVGCAWVEGDEPFRTEDSNRFGPVPLGLIESRLSFIIWPWERIGSLGQPLVARHDAKRGTPGWRKSQADLERGTWRTSRVTIAPSQPPTSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUD6</accession>
    <name>A0A2G8SUD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUD6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUD6"/>
    <dbReference type="OrthoDB" id="2532648at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="387" mass="43612" checksum="4438B90FEA656662" modified="2018-01-31" version="1">MSAFESLPVELVADILGELDVASLIIVSYLSRRLRAIASDSSLNPWRRPILRTICNSDGDGDYEPQLRHLSVRHTVPRQNWVDILTLAKAEYVLFEMTLPNLKETEWEECFRKRFLPGWAKWKTSTWKAAFLKILHRVWHRSHSACTADESWTKYILLNRNGSANLLEASSRNYNPMTTFHEIKLQNNLAHLPTHIRLVIEFRDVRIIALGVLSKPRSSFSVNQNARILLHPPGMTKGDDEVASAQAGHVSEGSEESFSPVLETPLPARAVHPINVKDTYRLLTQPLPSPCHSNYPFYTPGGEDKRWLGNEEVEEGGRQWVGPMMLTAQLLNPQTKQHLDDGVPNEDLDLVIGPGRGQYASLSWPDLTAIAPWVELTAKINGQGLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUK2</accession>
    <name>A0A2G8SUK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUK2"/>
    <dbReference type="OrthoDB" id="2748701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="405" mass="44823" checksum="8F68F43CAB1B922F" modified="2018-01-31" version="1">MPTIAAIPPELWEQIITAACTDGGFTGTSLALTNKFFNAQSLSIRFYSLSFTSIERIEAFLAFLAAQPNKCRPKIQHLYLSFVGAPNSAWHAPLNLWLNWSRERLDQAYKDHNSMEETRSQRFASAMTRLFALAGPHLRTLCILEPTQFSLPPLSTVTLPKLQELTLEGSCDFLVPEKPSDSPHAKTAATTPEGSQPPLSARFPSLERLHCVGRNWFNPKRVLAELAEHTPPSFTHLRFSGMATAGNKFPQNLAVQLGVRLESIVETHEPALALTPDADTTERLPHLRHLVIQGMEPEPRTMSGFLSERWAGMCGDFREIARKSREARGLQMVVLSTPWCRDPRWGDRLFDDWTDRLGGGCGCWVGPAEEEIEPNVSGGEDGTGIGEHEDVGDTDVTSGGPVRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUM2</accession>
    <name>A0A2G8SUM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUM2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUM2"/>
    <dbReference type="OrthoDB" id="435402at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033167">
        <property type="term" value="C:ARC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018606">
        <property type="entry name" value="Arb1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09692">
        <property type="entry name" value="Arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="783" mass="85449" checksum="21CAFB4400A8BE77" modified="2018-01-31" version="1">MEPSSPAAAPEQPIAAPSKNTSADATAPPTNSITITATTTPAPPPSIAPIPVAERPWLTFPPFPKPPPGVELIAFKDFKALGIIIPEPPAGGPAQARGQPEERGDREDAVGEIDGLGIQTLTLRVHHDLTTMEKRKRKNVRTKTLPDGSTVLKRWYDEWAEGENLRRTSCPIDPSLPRVDRLYQAAHDFKAGRPTIQNQAVNQLLTQYWDKFRLFVGLISSVQPTAVRKKNAAMRALAAQQAAAAEDDDDDDELDEMPNASLPKREATINVRTGGADDPAAPGQSAKPTGQYTEEERQHRREYFREVRDTRMDRFLNDPENVVKVFFSNYASDRGDLSSEKFCNNAPLLIDFFLKFLQRNRVFPDIDRQLRKAIGVAEQAIKELPHGIAMNKIIPDDFGRGCQQLYGNMNGYNVWDADSSSEDDEEDEARTSKKQKTDDTPVDMAVDQAASGSSAPAPVVLDPATAAEADVLKAALGGDLEVITPEAAKGMEKELENLGPSAHENDWGQVPTSTNAEPGLSWGDAPPSWGAGDDDPFLQSSTAADWECGPETNLVNRFLGPTTLALTHTTGVIERSTRRIKSVVVPPAPSTQPQQLQKKKKAGKGVLDPAPSPDPEGIERELDARLAKLTMAPWPTYAVHTNADVQKPRILPDSRGAAVLDDCKDAEVAPGPGVPHNPFKDDIVVYVAPEIVDRMWVGMSIEGVWVQLARVDPDVPIVLTDEQFKNLWGNKKKAEGGPGVPVAPTKVWYLEEVRMVLPSFHTEMTPLPTDEDVFGSGENPSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUM4</accession>
    <name>A0A2G8SUM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUM4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUM4"/>
    <dbReference type="OrthoDB" id="3064660at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005162">
        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032567">
        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503">
        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF22">
        <property type="entry name" value="TRANSPOSON TY3-I GAG POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="31421" checksum="71080E8C60DDD0FD" modified="2018-01-31" version="1">MSNAGTTPAPPQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLASGTQPWADFAAFEMAFKAHFCAADDKEAAIAELVKLCKGQHKIGTVQDYTVKFNAIAARTSFSAEDKRERYRTGLPYKIKDILATSGHDTSSITKIQAVALTMDQNLLVREEERPKQFGGGWRRKGEKAAATGKKPFTGNCFNCGKPGHRSFECKLPKKEQQAASSSGETTDLAALRAELKEIKERLSAVSVNETKEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUM9</accession>
    <name>A0A2G8SUM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="12" type="ORF">GSI_01175</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUM9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUM9"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12278">
        <property type="entry name" value="RRM_eIF3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000419">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034363">
        <property type="entry name" value="eIF3B_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="699"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL37481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="740" mass="85408" checksum="6950528312CBE714" modified="2018-01-31" version="1">MAPNGVNGSAYDDEDIDYSDIEAKYQVQYDEGFDNILVVDGVPVIDKSKLDKLLQKISKDFSRKGCPIKPENITMPWTESGKSKGFIFMEFKNGDDASRALATMNGHPFDTKHTFLINRFTDFERYLALDETYVEPPPEEYKSKEHLRAWLGDPQGRDQYATYRGDDVEVHWHGKPSQCEVSYSKVNWTDLYVSWSPMGTYAATLHRQGVRLWGGSSWEPQSRFAHPLVKLIDFSPNEQYLVTWSYDPIVVREGAEQGPQYFSPEDEGNNIAVWDIKTGHLLRTFPSAYPEGDDQKKQMAWPALKWSPDDKYVARVTPGQQISVYELPGMGLQGKKSIKIEGVVDFEWRPLGDRDREEIENENKAGGGKAPKKARENTLAFWTPEVQNQPARVSLMNFPSRETLRQKNLFNVSECKLYWQNQGDFLCVKVDRHTKTKKSIFCNLEIFRVREKDFPVEVVELKDTVTDFSWEPKGERFALVSSSDPNLGNPGPGITIKTDVSFYQHERSKGDFKLLKTLPGRTSNTVRWSPRGRHVVLATVGSSSKSELEFWDLDFNIEETRREGAPWGSGIQHLGTADHYGVTDAEWDPSGRYLATSASAWRHTLENGYAIWDFRGQELEKHILDRFKQFLWRPRPPSLLTKEQQKQIRRNLKEFSRVFDEEDAAEESNVSAELIAHRKRLVDEWNAWRQRCRDDIADDRRKRGKKADPANEKQPVEEEKEEIEVWVDEVIEQIEEEVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLJ8</accession>
    <name>A0A2G8RLJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_15083</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLJ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLJ8"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="7">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="195"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="6">
        <location>
            <begin position="343"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL22395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="71187" checksum="2ED258C3506DE21D" modified="2018-01-31" version="1">MSKVQLYVYDLSNGLAKRMSRQLTGRQIDGIWHTSVVVFGKEVFYGQGISITAPGQSHHGAPLQVVDVGETALDEDTFNEYISEIGSHYTADKYHLLDFNCNSFTNDCVGFLTGGSIPDWIRDLPSDFLSTPFGAALRPTIDAMFRRPTPGAAPTPPPAPNPAALQQAAAASPEPALASALLQAVASQAYASGSLSAPTSVPRASAPGSSTVAAPIHICTNNSSLHGLLQSHRIAVVFFTSATCGPCKLIEPVFEGLAHQKTQGPNGGRVAFVKVDMAMGSGGQVGAEWSVRVTPTFLFFLDGKKQHEMKGVNAPELRTQIDLLLYQAFPPHPHTKLSLPAVEALSMNPILFQQVPPLDTVSNKLVASIDAASSSPDMQAVKKALTTAVLPYLKSRFPDTKTGGKKPAVPATPQLLTSFSATTKTLVATLSPAQLFPLVDMWRLAAVDDSAAANWLAIATNPDPDVLQLLLDKALEVLDASDPMQKSAGRSYILTVLRLLANGFAHPALARALLSRTGPGGKRVQVTRVVVATLLYEDAAVRTAAASLAFDVAAALQKSRVDRLRGGAALVAVEEDEEWEAELVSAVLEALSQEIQSEEVVHRLVAALAFLLRLSPSYEGQLAPLLEVLQSRETLESKLHKGGCGENGVQKPEVRKLIQEVAAKLCPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLR6</accession>
    <name>A0A2G8RLR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_15140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLR6"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="224" mass="24971" checksum="C699D95EEAA37E76" modified="2018-01-31" version="1">MFRSEPRFLLVRTNLYAIQWMVRGNLTIYEADIAETHRRGLTYILGEMNSIACHGAPGVSNTAGAALWTIEFTLQAATLGIKELFFHEGIGYKYNFMQPISLNRSIVDGSPLDPPAPPHIQPPFYGGLVVNTFVGHTGGAFEVQGRRAILKRLVIEHADDTEGLTWAGQSYENSNVSPEGKLATEEVDLSEGFDIRSTCSSRIPDVVEYKNLRWFVYTLLFNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMJ5</accession>
    <name>A0A2G8RMJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMJ5"/>
    <dbReference type="OrthoDB" id="5544050at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="15133" checksum="9D5B8662970E9E0C" modified="2018-01-31" version="1">MSSSSTPVPSSGYASPAPLSTTPAPPKPNNAAPKPKPVNVFSNDGSFLERFQRLKKEEDEKKKTEETIVKKREFDNRFKNRGKRRSPDDSSSTPAAENPTKKAKTEEPLNQYQKEVQNYADRSLKDSGIGVRPLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN49</accession>
    <name>A0A2G8RN49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN49"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836152" evidence="1">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="14089" checksum="D1FC89B920FC3026" modified="2018-01-31" version="1">MRTAIFALVSLVASAAAQSVVIAAPAPSTTLSLGESFVVDVDRPASLTGSQEVAVAIGLRTCLGSCTGLNATSDIGTSLFAGPYAPAAVGGGSLDVAQNFTVQVPVLFLTGPALLSVAHFALIEGTEPFLEVVSETVNIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNL1</accession>
    <name>A0A2G8RNL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14407</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNL1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="242" mass="28745" checksum="9618B7AE21CF9CDE" modified="2018-01-31" version="1">MPVSQRRAVVPLPQNLVREPARSLRLRLRLALTLPLRRGRDPREVSPGLLARHRGEVPPVLLALRLRVGLRLRLLLRRVRVILARVHRGAHSSVDERVRARARPAPHCPRGHRHPRRERCVGRHDVPHVLVHAHPRLGLGYWGHRRRQPGRGLREEGEGRHAWGDRGQTVWSHHWHTHDKGMMMQRAHRVPVHVRGGVWRRERVRRRDREPRYWRWRRKGDRSGVGGMMVLLLRRRVRSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP17</accession>
    <name>A0A2G8RP17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP17"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP17"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="22782" checksum="CCA5786F156530FB" modified="2018-01-31" version="1">MPAITEGTVLVTGANGFVAGWIVKDLLEHGFTVRATVRSLDKADKLKGVLASAHGDRLQFVVVDDFTAVRSLSCRRSCRPTRSLTYDCTSRTARSTRPSRASTESCTPPLPSAPPPTTPTSSLFPPSGASPASSPPPTSPRRPSSASSSCPPSPPSSTRGGARPRTCGRTGTGTRPTSRRSRRKAVACRRWRSTRRARSSRSVRRGTLTPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP86</accession>
    <name>A0A2G8RP86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP86"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="476" mass="50711" checksum="11E00A837695514E" modified="2018-01-31" version="1">MLPQGLVIFEYIRKKRTNDSGVPLADASQSTLLEEWQRLPEKMKVECEKIEAHIREKKRAVISMQQSSPSPSTENIPAGSTIPDVAASPAATQHFSSPSPSTTPSPSTPLLSPSPFYSPQPAHHYPQDLFTAPPTPSQPGPLNIGDNWPSVEYGASPKVAFLMENQPSLSSGGRQMATNHNAHPHPYAPAGTIVPVPHLHGGQARTAQIAPLRRTQTVVLAPAAQTTPSTASVPSPVGNLRRFHTAPSLATSSNPTHVARVVKQPLVHAVPATPSGGHQPARPPVRDRSFSAESVEGLPLVPTGVRQPPPSPPYASVAPASPAAQVLAPTPILGSPRVYAHSVGHHVHTTAADPLLLSIDQPLPAETDSTTATAPVAPVPQELDLWSWQPLNTESDPLMKLLREIPTPPPDMIDFDFAAYLDDIIGPQMPVPALPEDDCPLPDVFQIWTPGHWSEGLLSSSLTGWNLNDFTGSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP88</accession>
    <name>A0A2G8RP88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_14622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP88"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP88"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="578"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="783"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="814"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="847"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="780"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="72"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="305"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="965"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="984"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL23311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113494" checksum="518706825BA16046" modified="2018-01-31" version="1">MKFAQYLDETQTPEWKKAYIDYRGLKKRISAIRHAHQSDTIGIADNEQLVLSPTSDRASDASVDLNVVGMAASPRPSRDTVSSGAHSTGPASSLRPGARADALRMHSREDQTLRSHSALSLTPARNDQLNPSASHVRIHTPDVEGRRPPPVRATTVQGQGAVGSGQAQRTRGSTFASTLRAFTLPRLNSLRGTTNGTVEGHGGPRFDLGRPIPLIELLPQLTAVERAFFEKLDQELDKVESFYSEREKDMHLRADLLKEQLQELKDHRRAFYEAHPATAAPSWLHLHLPLPPPLLPDILIRRRKGARDPSPTIRPHSLPPPTPDRSGKTWRSSISKHSDPPTHVHVLTSGTEGSGDQAEPHSDETDATLPAVSSGTGSGSVSGSGRRKSKALGVLKIMSPGFSPSPSPGALEKNATSGSERTDDGGADADNEEEEAHENDAGESSGSANPNLKSRQGSSKHGKGLPLRYDPEEYQHAKKQLKKAVLECYRGLELLNNYRTLNLIGFRKALKKFEKVTKIPAQVAYTKEKIEPSAISSGAALDLLIDDMEALFAARFARGDKKRARARLRGGAKLTTHHFSTFCTGMALGLGIPALAAGLYQSFQEETRAEIPGWGGLMFVYAVFFVPTFFSLLVGANLLVWARARINYVFIFELDLRTKMDYRVYFQLPAFLLSLLCYAFWLSFSRIGTRHVVPGTWPLLWLLFTGLVVINPLPVMWKPTRVWLLRNISRLLTAGVHRVEFADFWMGDQFCSLTFTLGNLFFVGCLYARGIDQHWRQCMPSPGPRWGIAFLLAALPLLVRLVQSVKRYVDSGLVTHLINGGKYGSGILQILFYFLWRSQGGVHGPMFVAWCVFATSYSIYAGAWDLLMDWSLLRPHAPYSMLRQELLYHNAIPFYYFAIVSNILIRFIWVIYIPTRGPNYIIRTFIAAMLEILRRWQWNFLRLENEHLGNIDQYRVTREVPLPYTHEDHSHDSDGDDEDDAKIHRSGSSRRSWRTPRRGRGFETDGTAAESGVVSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPG7</accession>
    <name>A0A2G8RPG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPG7"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="330" mass="34546" checksum="A3A7DCB59BAD71B2" modified="2018-01-31" version="1">MYRKVCFRLIVVVSPSPYSSFVTPRSAAQVITLVAFDMLSGLSILRPVSAGVALLLASTATSAAPHFARESNTSYSAIIAFGDSFTDNGSGAWVVSNQTWPANPNYSGGRFSNGPVWIEYVAGNLSVPLVDFALGGATSSNALVQGFTGPNSTIPVPSVDDQVASFLQPGSVPSNVSLAAPLFVLMGGANDPLFNASVSANQSFRALIASTAQLAAAYPAAHFLFLDYPDLARIPMDFYVSGTTTKDALHAYSTDLAALFGGAFPTGTAGATFVDLMPLFAEWEYYGAPGAFEFAPLGAYGSCLTGAYGETANVTLCADADDMVFWDEYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPI3</accession>
    <name>A0A2G8RPI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPI3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="259" mass="28029" checksum="146B1771478E148F" modified="2018-01-31" version="1">MGMMNPVVTASLFFVSSPDVGPPPFLDCGYDMDVSDVLYGSGRCRVIAARASSIIADTLVIIATWVRMWPMRSHLTKQKLTGVMFTDGSVYFIVLLGANVVALAFIETIELTYLIAQWISWQARLPFERRWLLRDLNLVCSFTVIFTCRFILDLHEAAATPPAVVPATTRHQALPGYDSSGTQFSDGNSESEPTLPVVPVRHGTGSMAKLDVSFGSMSIFGAMIPWIGTGDSEGGATGDRNREASLGLRDGSEDGSGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRL4</accession>
    <name>A0A2G8RRL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRL4"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="295"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="528" mass="59049" checksum="9B9ECC0CC9DE9EF2" modified="2018-01-31" version="1">MDGADLDTETMLAILSSLLHPLEFEHTVLLDALVKAQGDVELAARSLRPEPPRKKRKVSQKAGLQGWLKSGDKGHDSQDKAISSASANPDKFTPRRASSPAVLGTNVPGGSESSFSSPRKPSSRAKAVSNIEFMALFRPLNSSDSSSKPQAPRHPPLALVSPDHVAQHTPCTLHSSILPQELACRLFYTMLHASRDWNRNKWWLFDRVVESPHRTSFFVRRDISQAGEGSDLKEEAKYWYNGRPTDPPLTFPSPMEEACEIIERVVNEEMRKRKRYPLEWAGYPVKDGEEPVLWRANVAASNCYEGAKESVGFHSDQLTYLGPYPTIASLSLGVSRIFRLREVIPTDEKDQRNARTFNVPLRHNSLIIMHASCQEVFKHCIPAQNTIDMFRPPMPPPVDLAEEEELAKLSEGSNARINITFRFYRPDFRSQLTPHCKCGVPCILRPDMKNRYEAPPGNDLNAKSEPWTSTSEGEGSGKRSLASKYWWTCYAGAQNDGHGCGFWKVMDVKAEGRGPFVGDMISTTSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRU7</accession>
    <name>A0A2G8RRU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRU7"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="64"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="258" mass="28478" checksum="28951DFC53DA53E1" modified="2018-01-31" version="1">MSGSELYLSITPLKLSEIPSEDATLKAGRDILDETASWKQGKSYHHHLVKTSHRKKGPKDGAAWYARVSEHDKEDATFEEFWNKLGENKAENEMQYVPEIEKVQLIKQISPNQSVWTLFYRFPPPVSPRVFTVVQTTWLSETSPRTGIIVSIPVDVSGDADAEKLEEKGVKGRYTSVERVQELDNGKVEWRMATSSTPGGSIPQFVADSSMASTISNDVKHFVAWLKGVRGSKETAVPASTTENGVPPTAETEVAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRV7</accession>
    <name>A0A2G8RRV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_13999</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRV7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRV7"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF5">
        <property type="entry name" value="CELLOBIOSE DEHYDROGENASE CYTOCHROME DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013822626" description="CBM1 domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="234"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL24246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="55160" checksum="B3FA12B28E299EED" modified="2018-01-31" version="1">MARKLLIAGFAIAAASLASAQVASSYCDTTSGLCFQGYTDTAMDMTIGVVLPPLATPPSDEYIVQMVVPASYGWSGISMGGQMTNSLLVPFWPNGDDIVLGPRWADDYVLPTAYAGPKITLLPASTVNSTHVNAIFRCQNCTVWDGGSLGSGNLNGTAVFAYVASTMTGVDDPSDVNSSFSEHDYFGFFGMDLSAAHSSSYTQYVSGGASSTTAPSASSSTPTTPSSTSSAPAATQTEYGQCGGTGWTGPTICAAGLTCIAVSPPYYNSDDNLQTIYTKLTQKAFTELHGKPVRAGYVKYEWNNSFYNLDDDSDYSVFAWRLKSTSLGHESTPVLFLRDPSAPLPPSTEYRNASFYMFRPRPIVSPSPLDGVSLRSGKSRKKAAKAEEDDGVPNFKKEFERFHGENGVRTIMGSIGPVNNVRMLLKSGYRHVYISRKFAIQNGFIPRDAAPGHYGYSGLVNLGKWPITVGRTRTTHSVYLSEETHFDVVLGRSFVELRQIKFDPVDPTDVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRZ7</accession>
    <name>A0A2G8RRZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14026</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRZ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRZ7"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="23375" checksum="92732E389306A813" modified="2018-01-31" version="1">MNEEEIESILYIGREVSVYKIPPLKANEGHRAQEWGDLAQPLWKGRIRIIERGSGVALQFEDATTGELFAKADYDPAKPCVEAVLDSSRYFVVRVEDNGRRAYIGMGFLERSDSFDFNVALQDYTKRWRALKNPAEAAADQPSPHLPAGPKKDYTLKEGQTFSISIPGRASKPPTTSSSGVNLLGDLSGGSGLSSSSSGGIPTLLPPPPSAPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS29</accession>
    <name>A0A2G8RS29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PAC1</name>
        <name evidence="11" type="synonym">LIS1</name>
        <name evidence="14" type="ORF">GSI_14065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="11">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS29"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS29"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="13">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="104"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="231"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL24312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="435" mass="48642" checksum="40F93DD186917F8C" modified="2018-01-31" version="1">MSMLSERQKEELQKSILEYLHANNFTDAFNTLKAETGLEYTPDPKGKYVGLLEKKWTSVIRLQKKIMDLENRNAALQEEISLSPAKRASLQTDWVPRAPAAYVLTGHRNQVTKVAFHPTFNLLASASEDATVKIWDWETGEFERTLKGHTRSVTDVSFDSRGNLLATCSSDLFIKIWDVQNEWKNTKTFSGHDHSISSVRFMPGDQQIVSASRDRTIRIFDVASTHLVRTIIGHSDWVRWVEPSDDGRMLASCSNDQTARIIDPQNGETKTELRGHEHTVEVVAFAPLAAYAAIRELAGIPNTERSKRPGAYLATGSRDKTIKLWDTQSGQMLRNLAGHDNWVRALVFHPTGKFLLSASDDYTIRVWELATGRCVKTVQAHGHFVTCLAWGRQAPSQSGDAAKTNGVGDGHQEVEKFVNVVASGSVDQTIKVWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSF9</accession>
    <name>A0A2G8RSF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSF9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSF9"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="524" mass="57579" checksum="5198F2D48403552B" modified="2018-01-31" version="1">MTSSKPTDQNYTSLASIKSSSTSSQLIDILISNVWPDGITGFSAAPLPAPELSSIGVDPVAEVVRRTKPRYHFTAGGGHPPRFWEREPYTWDNAEDKGRIGRFVSLGAFGGEQPPGKKPRWFYAFSIAALSATSEPPPKPANATQNPFLHRAPKRRLESGVQQLGKRSRTDAAGADASQTVRKGSRLLGTSARFASQRSTSLRTARSGRSRRKDMYAGYAMNLATSFETVPSKMQSATPAVVSLGTAMYAEHAVASCITSKIVQSPTKQARAREGVALQKRSGRVLVLLVESQLGETSHRINRFRVLCDVAKRATHPHPPGCEPPKCAPSTRRRPCPHRPYHPLSDVPLNTSRPGRTYYRRNREVQVRITRDVREARSGNGLLRGRANECQGRTRTRTGGSRSQQAQGRRRGHVQRRGPRGQCHVRGRPGRSAARGCGWPWGLLPCRLARWAEACAPHARAWTLQHPVRKTGDGLRSWNGRSVRLEGVHTVGARGQRGCAGVQGSFRAIRSILGMNINMYTVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RST1</accession>
    <name>A0A2G8RST1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RST1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RST1"/>
    <dbReference type="OrthoDB" id="128646at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF15">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="207"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="31897" checksum="229153F3166FFC3D" modified="2018-01-31" version="1">MSTAYHPQTDGQSERWNQEIEAYLRMYCSRHRNDWVKWLPIAEFAFNSHVHSATGYSPFYLMYGFEPQFHIPMLSTVVPSADERREELRQAREDATSALTLAAERMKEYYDRYVCDAPEFKDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESRRYGRWKKLQYLVHWMGWGPEHDSWEDAADLVNAPKVVQKFHSTHPDAPSPLNKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTM0</accession>
    <name>A0A2G8RTM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTM0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTM0"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF3">
        <property type="entry name" value="F-BOX PROTEIN POF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="633" mass="69349" checksum="960FEB7F0BB4CC5A" modified="2018-01-31" version="1">MPGIADVPVELFFDGIFTFLPVRDLLNFGATNRFLNSVVDDEAFWHRKIEQDFNFSGSDTARQTGWKFLYKRLSKPDAYVWGEKSHSRLGLAHPPHTNIRDGVPYPVRLHIPGVRIVSLAAAGMSFHALDSQGNIYVWGVLDGTNTAFRSDGFSEPSKEAQGPMRLDLPAKFRALSCGRLHMTALDATSQVWTFTSWGRPFRLDSSLVDLSSPDTTPVQVESGWSFSSILTESGDVLVYWPSSGRFKEAIDKKMEEFDSSDDEVFVAATKARPSESEPSVVPCHWWVLHGADLVRLPPIPASSLPEIRGTGLAQDALDRETKLVKIAALDNNIIGLTNKGHVLRYGELYGGEENLTGHWEYLPLFSDVEQIKDKFASSDPDTNANPGLTLPDTMLITHVSASFETFFAYSVGDASSVLMGKHIPAQSASTQHHHSLINSFVPTIIPELQNQAVISVILGDYHYGALTATGKLLTWGQFSKGALGLGDPMDIEVGQPGGFASEERRLQAVRPRLGLIATPPDVRVPTEVRFDHGQKQKRLRYCFAAAASGWHTGALVIDLDPDQDEEDAEEQQIPGSFPTGSDDDDGGQGPLRHDDTMAHIMPIGFGPGRGMNPFRVGFAGRGMHRGVHPPPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTW9</accession>
    <name>A0A2G8RTW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTW9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTW9"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="503" mass="53032" checksum="F49CA4E34C18E2B8" modified="2018-01-31" version="1">MAVFRKVQRGRSEGKSLWAVLDADLPCFDGGGFKKSLCADMNNGVSSHKNSRKRAADDGVGPRSKRRKANEEPVPTPIKPPYFPPVVQNTNQQSYYQAACLQQAHTPAENLFPPLPASSNFHRVVARAATIPLVGAPLMVPSDGASSTGAGEETEGEDDLIPPSSPIERPPSSSSLPDLSSSLSTSSSPTPSHLSYPSSRDPSPAVATVPPPAAELPNDIEGDPMAAWLRSDSPPLSIPTLSAKAKGKAKITPPPRSSGKKPLRMMAPMHPPSSPTPDRRGVTGLRRVVSSSKPKSPGTIIPPSLVHKPISPSSVMNRLHASLIASAIAAEGSQGSDDVERPLTPDRAVTPPPSSTPLRVDDLESELIDFSPFKSLSADVAHLFGASSSSGLLPPSPSLSVFTARAPLLQGSMEDLAGDWMSAISRSPIAPIPRTPKKSPLFGSSSSAQSLRMFSPFGTPSRGSRDALLDPEDDWMRHFQSPSDLFAAYTTLGASPSPSQSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU45</accession>
    <name>A0A2G8RU45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU45"/>
    <dbReference type="OrthoDB" id="2210012at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="306" mass="33328" checksum="2B22EEB576803153" modified="2018-01-31" version="1">MDAVDLNWCLACGCRIEIDACTPYCSQNCLNADAPSTSAYPSHSILPSFDERDSFHNDEDDDSLHEDYFPDPQPSSPVQNSWIGRGDAGIRAWAQAIPRGAPCESEDSPSRTLKPKLLLQPRKPVKPSLCMSRAQPAPPEPSRPILTPQQSLPSVSRDLVSIPSTSMVSLTTGSSSYSVVTPATTSEVGSFRDAPVPRSTTHHHNFLGGLKAQLRAWATSSTPQKEAPRSSTLTRAPAVHIADDSDAESTLGHVPKVRRPRSPAPFFHMPEQYPREKSIGATKENSLPLDHPAYRTRGRKASRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU75</accession>
    <name>A0A2G8RU75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU75"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU75"/>
    <dbReference type="OrthoDB" id="3246760at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027806">
        <property type="entry name" value="HARBI1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13359">
        <property type="entry name" value="DDE_Tnp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE Tnp4" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="168" mass="18934" checksum="34CBF000D914945F" modified="2018-01-31" version="1">MGSAHDATAFEHTGAAKHPDWFFTGEEFAWTDSAYPLNKRTIPVHKKPASLRRENAIFDHAVSHLRVRSEHCMGALKGRFQCLRGLRVAINSPETHFKATHWIKVAIILHNLVIDVEGEVSGAQFAALHTHVKEVEDSGDQDEELDMAEIEDEGERKRNQLIAELLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUZ1</accession>
    <name>A0A2G8RUZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FTP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUZ1"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013876651" description="FTP domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="8">
        <location>
            <begin position="83"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL25330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="225" mass="24722" checksum="AD55B554CF5BA017" modified="2018-01-31" version="1">MRHFFVAAVAAAAAAGLASALWHGSPHTFRSRRKTMGFGPVLSHSSFHTNPVCPRAEEPFKVAQIFVEDLIGDILGSSYQIRKDSYTDQATGVTHIYVRRYMNGIEVADGDINLNIKDGVVLSYGGSFFRPQKGASPHTVVRDVDPQADYCRALEREIVSQLRKVDVSKPDHGVDMEALGQLGDLYDWNCQFVILPDFMAESPGSARSTPRQAMMSPARFSSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVE6</accession>
    <name>A0A2G8RVE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVE6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVE6"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013795674" description="Carbohydrate-binding module family 19 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="38989" checksum="A93A563F6A098409" modified="2018-01-31" version="1">MKYSVFATLSLALTASARPNFLTSKRADFTLKNGEDAIALNDKFKTLTPTSACTNGDVACVNDKFAECANGKFAITACAGGLICAALPLDNSAGTTVTCTTAADRDARIAATGAKAGATGTKADDGKKATGGKNTSSAKASGTKAAAPPTETAGNNAANGDATGDPQKSLTLSKDSIQANYANDGSQGASAGQEPSLTSTDNFINFCLQFPGKQKTNGQQVIEGSCNQTPMGLIAAKTNMPSAKFQAPANGDKIAANKDFTIKLAINNLETGHFTNPATTFHMAPQTVNAQGNIKGHSHVVIQKLAALDQTTPVSPTDFVFFKGLNEKAVNGVLTTTVPGGLPKGVYRIATINSSSNHQPALVAVAQRGALDDMVYFTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVG0</accession>
    <name>A0A2G8RVG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVG0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVG0"/>
    <dbReference type="OrthoDB" id="2754621at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="420"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="600" mass="65274" checksum="49196356E62C90F9" modified="2018-01-31" version="1">MTQVNRDLSWRRSEPPISTNEIPSWDDTELPHLRSLTIPGLCFTRGIAVASLKTLVLSDGPRTGSHDIFLSALERCSRSLESLTLHRWVHPDPVTDALASRITPVVPLPNLRRLEIELQYNDGDMPPPTSLFAGLSLSPSVAIHIDWSCNPENTRELLRNHLSELHFDSVSLHLSGPPKTVSVHCFIGDTELLSVRAHPTLRDPLGHKAQSLVTKFLEDHRYATATQLAVDLDVFSQDGCTSLVQDDALRRFVDAFPNLRRLDLLGKTIGRAKLAMAKAFLDLPHPAAYHPTTQGTGNFKTLGYVFEVSEQQKAQNPIGFVDVLRAQLDALEALLADSAAAGSSRLHRLELCVVYTSLSQPHPPTETYPYVYDVSASTELTAFESPLPVFSAMFPSGFTNLLPLALSFAPFAALWGDAVTVQLDQATVYGTTNGSVTSYLGIPFAEPPVGDLRLRLPKPIESYNGMIDATQVGPRCFQLLPPLRTDMPAELLQDVVAALTALSPVETQPESEDCLNLNVVVPAGTPAGANLPVLAFIFAGGFSWGSNTQFDGEAIVVQKSIDMGQPIIFAAVNYRLHAFGFLGGKEVKDAGVANLGLHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVP0</accession>
    <name>A0A2G8RVP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_11327</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVP0"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL25580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="575" mass="63728" checksum="A512A19260803E82" modified="2018-01-31" version="1">MLASVSDASSPGPSIAALAIPAALLMHQLFRRYETFSVLTHAALLLGPPALIAASAVSDPSTNPESFKDAFRSSVLLYLATLAISIVIYRISPFHPLARYPGPWLAKVSMLAPALYSATGRRNRAVRRMHELYGDVLRIGPNELSIRDPAVAMTILGASGLPKGTDWVGGMLRDHNLPVVGIRDIDEHLRRRRAWNRGLGPAALREYEHVLARRAQLLVRRLEEQAGEVNLGQWVNYFAYDFMSDMAFGGGSELLSEGDKNNVWAVLDKGMALATFFGHVPWLGVYVGHIPGAAWPLNSLHRHGEKCAAKRLACGSTTSDLFHYLNNEDLPDRAPPPARQLYDDGVLAVVAGSDTASSAMTSIFNCLLTHPETYARLQEEVDRFYPAGEDAFNTKQHRDMHYLQAVINEALRLYPPIASASQRHLPRSAQGITIGSIYIPPGTAIRLPPWSIHRDACNFTFPESFWPERWLIASGHLALSDAPLPSTLPEPSADNKGKAAFVHNEQAFLPFSVGPMNCPGKALAMQEMRMVVAALVQRFRMRLRDGWDAAFYEREIRDYFNATRPRVPVVLEKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW63</accession>
    <name>A0A2G8RW63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW63"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW63"/>
    <dbReference type="OrthoDB" id="2752751at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16372" checksum="F816C33C84A908E0" modified="2018-01-31" version="1">MNANSLMAVIEPLLSLHRLRYIVLDFSPFVLQLSSDDILALSKAWPAVEELVIDVATAQSGRAGFESILHFARRCPCLQVLHLPVMVIEPGAFEGLEYSAEPHPLRDLDIEEVVFPPGMDFSREKMDFIQRVFPNVAVASATHPIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWP0</accession>
    <name>A0A2G8RWP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_11683</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWP0"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="87"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL25930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="160" mass="17395" checksum="4C56F1FC3283CD64" modified="2018-01-31" version="1">MSDDEQHNHNFEQANAGASATFPMQCSALRKNGHVVIKGRPCKIVDMSTSKTGKHGHAKVHLVGIDIFTGKKLEDISPSTHNMDVPNVFRNEYQLVNIDDGFLNLMTQDGTPKDDVKVPDGDIGKEIQSGFDDGKDLLVTIVSAMGEEQAISYKEAPKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWX1</accession>
    <name>A0A2G8RWX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CxC5 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWX1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWX1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="1">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="183" mass="20682" checksum="869C2BBDECEA8947" modified="2018-01-31" version="1">MLSIKVIYTLLQASDNLSLGDGAPSRITETVTLQTLLDFIHSTTCLRDVIVHRQPPSAPPDSIPDSLPDDIQAFLATRLRLPVPHIDTLWKALRVVIWTEGDLVVGDVLPRFQDDVGERFKLAGHMLYPPVHVCDQQFCPEPTFLRHKDAPVKVYLFTMDRGVCEAWSTHLYCYCVLPYQLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXB1</accession>
    <name>A0A2G8RXB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_11910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXB1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXB1"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000149">
        <property type="entry name" value="Glycogen phosphorylase, muscle form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL26155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="859" mass="97390" checksum="C882CA2E44A856C9" modified="2018-01-31" version="1">MTSTIDPSTIGKPTKHTKTGPRRHVRSLTGYTAETDATGKEKWPIGDEKVWKEGIPGIASDATTITKSVVNHVHTSLARQAYNLDNLGAYQASALSVRDNLLVNWNETQLHYSRKAPKRAYYLSLEFLMGRTLDNALLNLGLKEKYQDGMDRLGFNLEDLIDQERDAGLGNGGLGRLAACYLDSSASQELPVWGYGLRYKFGIFQQLIAPDGSQLEAPDPWLEHDNPWELARTDVTYQIRFYGHAERVDGMKAIWQGGQEVVALAYDVPIPGYETKTTNNLRLWESKPKRGFDLQSFNAGDYERAVEASNSAEAITSVLYPNDHTTFGKELRLKQQYFWTAASLADIVRRFKNTDKPITEFPDYVSIQLNDTHPTLAIPELMRILVDEEDVPWNKAWEITTNTFFYTNHTVLPEALEKWPIPLLENLLPRHMQIIYDIVRNPFTLHPGHANFLPFATSRCRTFRLRFFLQAVEKKFPGDKEKLARMSLIEEGFPKNLRMANLACIGSRKVNGVAECNPGLSNLISETLNLPKAVFLKDLFKLEGLLEHAENPAFQKRWAAVKQSNKERLAKHVEATLGFRINTRAMFDVQIKRLHEYKRQTLNIMGVIHRYLTIKDMTPEERKKVNPKVVFFAGKAAPGYYIAKLTIRLIVNIARIINNDPDTKDLLSLYFLPDYSVSLAEILIPASDISQHISTAGTEASGTSNMKFCLNGGLLLGTVDGANIEIAEEVGESNVFFFGHLTPAVEDLRYQHMYHPVPIEQKCPPLARVLNEVASGRFGDGGAYEPLLNTIRQNDYYLLTEDFDSYIQALKLVDEAYQDRTEWIKKSIRTTAKMGKFSSDRAIQDYAQEYWNIESTKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXS1</accession>
    <name>A0A2G8RXS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXS1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXS1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013923529" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="101"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="536" mass="56542" checksum="255481165BF8937D" modified="2018-01-31" version="1">MAFPCNIRLLGCIAILLSLAPWSVHASAPTVEVNGTDIIGTVQTSTSVDNTTVEFFGGIPFAQPPVGVLRFASPVELDSLGVPTFNATTFGPPASSPIPGIYGGGFNSGLSAAYDATNIVGQSLLRETPVIYVSINYRVGPFGFPQGTEAGLLGAVNLGLRDQLAAISWVQKHISAFGGDPTKVTLFGQDAGAMSIGHLFLNAGLENYGVRGVIMESGSSGSLPLFDSSRRDLVWDAFAANISACAGVLRGSTSPCLRCAPTSALLSSWEAAAAVLPDLDLFVPVLDGPDGLIPDLPSALLAAGRVSKIPFISGTSFVPQALSNPIHLFEFFPAAEFPYPQTYSPQFRQDIQGLLIQYYNDPDLRSPFGTGNETFGTGDLYKLAAASFGDITFEAPRRQWTQAAAAAAAGVTVYSYVFADQNVAVADPSLGVRHGSELPYVYGFSNIETSSLESVLVSRAMVDYWLSFVASGTPNDGKGLTRTIWPNYESDNQVLIQFDTASIASGSSNATFAIVADDYRAVPISFINSVATDFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY06</accession>
    <name>A0A2G8RY06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY06"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY06"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="281" mass="30942" checksum="65224E9113DE1576" modified="2018-01-31" version="1">MSAEKEVAVRASSDTTPKTKPAPKASAIPVPFVYHPSDDGTDENLLVLLHGLGDTQIPFGKLGRQLHLPQTAALALRAPEQIPFLYEQAFQWYTSFDPLGELIDRPNPTPALELLSKVIEHLTKDCAWPPQRIHLFGFAQGGSVAAEFALTYWRTAILQHQKALLPSSSSLDLGPSVPTPRTLGSIVSVCGPLLSYPTLPERCPTPFLIFHRPPPAESALPSDAMTALRKGFIKVEEVKMKGEGMPRSKEEFEPIMRFWSEYLGRRPMEGLYEVMSGIATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY86</accession>
    <name>A0A2G8RY86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY86"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY86"/>
    <dbReference type="OrthoDB" id="2749284at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="428" mass="47633" checksum="1320DD9BAC6BDD6B" modified="2018-01-31" version="1">MEDSTVNLIEFWKKNPPRPQEHIPFRSVMNPLSTAFSTLEFREEIVGRWGFHKKKSAEVAIFSFAGVISQADDMETGNLVPEGEVAQERSSWRKAQCKANSWGFYTIVLDTSTDSELFELMKKLDNFVANDTAFGCTSRSRRAFMSGAEPRFNSKFWMQTPMFLPVGSDPKPQPPRHLHRWVKDADRASSLFRANPARPVLYGRRGNVPVSLAECDPNHLRAGDIVAIAFMIVYYLTEKEWYPQYQPVEVYVLKRSMVADIAAYEVSYVDRPPPTTMSYDEVEGVVAGGSRGDKKDATEGGISRKPDGERSGNVEDLYATPHDPTTTPSFATDVQGGSQKPSDECDPPGSSETKSLKRGESRVNEPQLKSASDDDLEKSSTSTMSDGNDSKVAARKRGVQRGVEGEDHEAADGNQEGKRKGRKNVRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYB3</accession>
    <name>A0A2G8RYB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYB3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYB3"/>
    <dbReference type="OrthoDB" id="2755325at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="560" mass="61304" checksum="9D3C5C3453F30121" modified="2018-01-31" version="1">MAPPDPLWFLLVPPESRPKKLTSEFMDAVLSERTYTDPARWVRFLWYARFVRVLCIVTSDDLESKHRELVYALMEHNGGASPFPSLLDLQWCPSSYSDSSYFPLFTRQMCVAAFRIPRPTQEHPYRLEEDPESHIFLTRLQAASPRLCFLAVDASWQRLGDHHIRAICSFDGLVDLDLTASLSMSSFRELAAIPHLKYLKAGQVLSDTDSDTVTRALASPAGGLSHPAARISAPRLQLLSLSGDCHLLAALFAALCAPNLKTAAFTAVCRDPHPPTVGYVPCLEAVAAFGTLEELQVALHAPVPRERVHLAALLDPLLPLRGLAHFLLMSANRDGRGRARGLWLVASDADFAALARAWPRLRTLRFMDVYWDASRADDGHEGGAEGEGGPGGDGPGEAGGIAIPRRGLTPTPEVLRLFRDHCPDLWQLMLPYLSLDGGVPQLDLVAQDSAPPHVLRRLVFGATTDATGNPGGDEGERERAREGKVARVLADDKAEEWARYILGLFPNLNEERSIAECVSLSATSTSGWIEVLQRVRELRSSGRSSESASLGGMVAELTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZG8</accession>
    <name>A0A2G8RZG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZG8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZG8"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL26887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="819" mass="89105" checksum="C16D8DA54335C9F8" modified="2018-01-31" version="1">MLSPVSPSTVSLVLLTSSSHSSPSRYAPTRPSALLHVPDLGTARARDPRRRRRPHPPLKCSHHATQSSPSSFLPFHDPAGPDLAHAVDDTLAVIEEDLLFDALPTSTQQLTQPQATQSQGDTDIDEDVDMGDMGTPHTTVTSVLLNLNNRDVCLYEDWTCKPTAPSHDALRPPPLTLHEIIYDPPELDLRTWRALLLPRLAIPLKGKYHFSQTELNDRIQSQVKLGWKIFFVDWDVKQIYGDMCPSIGYPGEALSPLPIAIRSITESSYVGDPASIYETSTAWMLWGIEVKTIMVVGELTGIQMMRTGTLINIQIKDQTGICNVYYLISQAMQKEVHSDKVKQLTIGAYILVVGRLSAASEEQMHATTIITSICPQVVSENIYDLHYQISDHISRAISMYLIGRRVAVINGFYIALFKDLMLTQKEFSKVGDIAFEDPRVLVALPIIKRSMYRIQNQDPIAEVGVACLLKIALPRLARAHALVPEVIAAAVSVAMWAGWLARANLSTSTPRLHTADDRLTSHTRLPPYLPVGVARALQASPTTSPAPTIFTHEFSLTDRVALVSGAHRGIGLEMALAFVEAGARAVYCVDLPKTPDENWVKVREYAKALAGNMGTGEARLEYVSGDVRDQDGMWKIGKMIGDREGRMDACVAAAGILPAGPEPCLTYSAEQFQAVLNVNMHGALFTAQAAGQQMERFGRGGSITLIASIAAHGVYRDIGLLSYSASKSAVLQLARSMACELGTKGIRVNSISPGGIRTSMLENGLLSGAVASEKAIAEAHVLGRIGRPDELRGVAVWLASDASSFCTGSDFFVSGGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0H9</accession>
    <name>A0A2G8S0H9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0H9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="20048" checksum="B847425DA1263993" modified="2018-01-31" version="1">MVVDNEQDTKGHQARPMVPWENMVILRLYAQSSTASRRTYTERFDALIKSAIDSRAHMEAESEDEDGDEEEEGGSSSAPGPRTLQETVRAQPHPEPPSRSRKKGGKTTIRLADLFLYPRAPRGYDGLSPAEKQVFEASDDGDRLRRLRFIWKMGEVQYNNEQRLTETLQPDGRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0T4</accession>
    <name>A0A2G8S0T4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10531</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0T4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0T4"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="33"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="531" mass="57833" checksum="DF48F39ED85EE6BF" modified="2018-01-31" version="1">MGQDESVCELEAAQGGRSDVFGNEDEHDIRYKTLSWQFVSALMIAEIVSNGMLTLPNAMAVVGIIPSVILTVFLGIFALWTAKLLIDFKHNHPEVHNMGDAGFIMFGPIGREVFSIGSIIFAIFAVGAVILSGQQALSVLSDNGLCATILLAIFSAATFVLSLPRTLAHLSWLGLLSASFIALCGLLAMVGAGANPVPGRIVVTTVPTNFYQAFLAITGPVFSYAGHFMFFVLISEMRRPQDAMKAACVLQGFATTFYAVFSVVVYAYIGSTVASPALFSLPPVWAKITFGVGMVNFLITGAIYAHTAAKLVFIRLFRGTQHVYTHTILGWTTWVSLCFASVGVAFVLASAVPIFPDLTGITASLFASWYTYGVAGFFWLYDAFHLKGGLDALKRRWFGTTLAVATVLAGAFICLAHYRLLARTNPARLLRDRESSVVYTQDERHRNSPRARHYYELPERMPGILRDATGIEDVEMVGAEGLLAGGLDKMVNESEGEEFEPWVEKCLEVGTDEDEYGWRMADHVVGIALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2F1</accession>
    <name>A0A2G8S2F1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2F1"/>
    <dbReference type="OrthoDB" id="2757546at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="293" mass="33156" checksum="A11B99696D25C3FB" modified="2018-01-31" version="1">MTLRLLWPLQNFGPRSQQVRSFLYFGNGNPCGIPGPSSKLLIPEFGPRIAVEEASPQDVSNIGERHFRCWTVRLLSMTLLVPLILPPNHGSSDEPYWKAKTISFPNMDGHGGMQAELDSASARSYVPISVYNDIRRSWLHQPNNAPGVSIVHTDTFLPDANPFQNHDIIFRFKGVDEEEVEFRCSAERFLVSPWFVPEEGFIVPFKAFRPYKDDETDAATLGMNFFWTAIVRFDAEHRGLRPVPGIDQPYVQLAAQRIVKDGRVIADAHDIEIHRDAPPRVQAAARKQLALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2H5</accession>
    <name>A0A2G8S2H5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000031">
        <property type="protein sequence ID" value="PIL27966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2H5"/>
    <dbReference type="OrthoDB" id="2753012at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="15"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="297" mass="33610" checksum="1ACE6D03E0FB845B" modified="2018-01-31" version="1">MSQPDSDHTVRNYGMSASFAWLLFEYCITLDQEIDLFWGQKVTGASVLYLSNRYLPLFSSLWWVPWWRQSLSFNEILGGLMEYAIYVPVAAFSALRVYALSGKNGKWAAVTFLLSVSPCLIALVVCPWITFQTDPSTACRLQYNIPFVVQAMLFLVLADVVVLSITWSTTFRNWKLRCNIPTISGIIFRDGTIYFINNNARRRAQLFLNAFYLVSMLLPPDIFDVENLNSIASLLILPATSVLVTHFLLDLQHASRQSLPPINASNWERMMGSLALLSLDVLDGEEHERRGAPPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S368</accession>
    <name>A0A2G8S368_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S368"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="108" mass="11914" checksum="9EADF646C408CE37" modified="2018-01-31" version="1">MRKPWIGYVERLVLCLYAVAFLASSKLELTRGAQQHAHTPPADSGGWHGAQSMSLIVSAHNYTRLPAQIPGVRRSASLDLVRRGLRPPHAPMLRLVSSRHTEHMAGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3E2</accession>
    <name>A0A2G8S3E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3E2"/>
    <dbReference type="OrthoDB" id="2757062at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="338" mass="36445" checksum="47319FC3C5859506" modified="2018-01-31" version="1">MTLDHVPIALPHPNDIAVNKHALGIMQSFAFDATSLVLQFSLSSLLFGVLTILALSSVFLLLRRRALTNASIRIPLLTTVVLYASTSLYMAGLIWNWTSVTRIIREANEGLSSESYDGAANLISLENAVFKQSWMATAGLAANVIVGDAVVWWRACVIWRHRAVYYAGPIALLLTLAFGIVGALQSYPGPIQSIYFMVGGGGFADAAAALSLATNLAATALISIKAFLHNRRLTKYLGSSGGKTRALKMFALLIESGSVYCVILLVVLVYQFNSDTAGPIFTAEYFFVYGCLVPLVAIYPTGIVFLTALDWSPLHWGLSESMVSQGPLSTSEYDSETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5F2</accession>
    <name>A0A2G8S5F2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5F2"/>
    <dbReference type="OrthoDB" id="10569318at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="153" mass="15796" checksum="BC6C9F46C4CAA845" modified="2018-01-31" version="1">MSSRESRTLVNMLMLYAINTGAATAAISLSVVIVYVCVRTTLASTGLAEIGAKVYANSFIGSLNSRAFLRHKNLNPVCSGFGGSISDIEFTASESPSGSNATPSAGQSVALVEYSGSTACEPAGTPAGQGETVHQTKLQVTTERECDPGTVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5I8</accession>
    <name>A0A2G8S5I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5I8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5I8"/>
    <dbReference type="OrthoDB" id="3251367at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="656" mass="70677" checksum="D9420B19BE9FFF0B" modified="2018-01-31" version="1">MLLATFNRVFRPVTASFDSERSREFDPLSGLSVRPRLCERDEDDASSDGDRNINIGDLCLSVDSDDAPLLARRHSPQPSTSTTTTVTVTASGEILHAGPSHVYWKTPHLDSGIVLGSQRPSSRAGPASSNSVDYASIHSHTPTSPVLWGYHSISRLRKYKPSSLGRQSLRSLRLPRDSFSASEDSDAESAHSLRDEQPALPKQLSPIHEQQVPFPPHRKLSVDSVRTPDSTRTFDRITTHSTHSAFINRPLKRSISQTSTSTHLSAMSAPTPPLIPPLDLRPNFQATMGSVPSQGRQSPIVLQLPTPRKSRLPTPTLPTVIGSPRQTNMVSVIYEDGASASASARSSAGSADTSGTASTARPAGLCDPASPQSRSDADGEPDTRPNSLSLSRIVPRPQNPVPPSTHSRLETPRNSDSGVLLRPLPPSPDWLSADGPEAPFLAHSDSGGQRSELRLKGTTSFGSAPFVHPPPADAQRERATHACVLFWAGFVAPWCWLIGGWLLSREGEPEGHGPILPLWHRHRHLSRRRGAGRGTHVPVDRGDGCEYGELDHQQHARGVPCGDGGGAHEFRGSGTASEKRAKAMTSWYPLFAPSVESLAPSTRSLSSAHKLRILHDHGARGVDPWIARCRVAAGVSGVFIFAGFVVAMVFAARVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7D2</accession>
    <name>A0A2G8S7D2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7D2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7D2"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32083" checksum="1E88579CF10CAFA0" modified="2018-01-31" version="1">MKRPNIYHKATEMSWASAAAGKKVEAIYSRVVGYLLLRPPSETARGAVELELESCNSNSEPYLAVYGLEKKREDSTSLRAFFPPFFRSDEGRLFAECARHPARSFQRRVKAAGLVRDNYRCMLTGRVDIKYGTLQPDRPFSATRTQCCHIFPDSLGNCNIAVGGTGGGAKERQAATVWTILEQFGYGDVCDQLKADAEGTNFHRMENVMTLDMVVNHWFDELMVWLEEVPGEIHAACCRIAHLAGAAEHLDEILDEGEGMNVLDPDGSSARVLEYYLLRCGSRLVPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7E5</accession>
    <name>A0A2G8S7E5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7E5"/>
    <dbReference type="OrthoDB" id="2986010at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="162" mass="17816" checksum="E24D2DC02C42ECF5" modified="2018-01-31" version="1">MSDTPVQPEQSVEGKIPQTPPPLSPQLSDTTLPTYNNVISPPSGVPSGAGIIDWPVPHVIVFFRKFKRAYGRAGIAQLGYTGFVKELYLGFLWKRKIQRTVKTLDADFADSTFAKTATLRGVFYAVHGKDDVGLVRLGHIGWAGMVQNLVSITVDFEDEPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8G1</accession>
    <name>A0A2G8S8G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8G1"/>
    <dbReference type="OrthoDB" id="3063716at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="307" mass="33707" checksum="36E32E943D5BAC47" modified="2018-01-31" version="1">MIPKHSNPFAILSSTVTVSRSALRDSDDEDEPGQPDAEHAQMLARLENILKRTIEDVLPPASQVGGEHDEDAPRKKKRRKVDKQAEGAEQKLEGEEDGAAVSFRLLSGSTQPKSILLAPKIKPWIAPEGPALEDTAEEAKRRASRARSIAVDYAWIMNESTKPNVPPLGRFKAVAYLQADVSHANAPLLLLERTKPTAPKPPRVAQSNPEADVEPSPHTHDISESCCPIVEVKASSTDNGKAEKRKRRRGKPNQRPSIQPTFWRPPPGFGGKALGYAWGYAGSHPLQPGESPQYTRDTMKKAEYEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9S5</accession>
    <name>A0A2G8S9S5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9S5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9S5"/>
    <dbReference type="OrthoDB" id="2801156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="858" mass="95993" checksum="DF28F28A5C5F0D1C" modified="2018-01-31" version="1">MKTMTLVDGLNASVPLTAFASPEVVVVTWNGELVGTMGQLGGSSLRAEMRQVGAMAVKVKVPELQYAELPQMAKTKWSPAKQPSASEGERSTLFLHSVEPTTTFASTTPPSPRRPHLRLDDPTFASTTPPSHHTLAPRRTTPPLLDTITLALDHHHVPARHRPANMRSTVFTGMLNVEPYHFEVTFYKPYEEVKASDVLDAAKEFMVQYVHRRCKIKWVLSEVKDLFLLRFLKQEDAFVVGSEPPGDPLSDRYPSNYSRSAADWYWGTGYHMSSEAVHTDSLLSHWLESQDATKVRWYVLLKVPLEPTSQFAPSGFEDASGLAQHRIAYMNAVEMDVENRLETGVASPAKVSADVSKFLSEQKTRTPISNGLLTHSDYGVNPIVLIPIFAEIHNMLAHPDLVTLELSQEVSSFNAKRTTSHFISAVHAKVKDEKEFNAGIFVVLKELLGDIVELHLHKVFNDKAGRTTEIDWVAFCRTAHGWMCVPFSGEGKMRRGVGGDSILQNFCALQRLLATQPDLRHFMQLTACPILMLAVEGTDMRVWGMYFGARIYGSRLFDVSLRKDLTSQERLKIAIKLQLVRNAVRKLCDFYGRLHAATRPPTIPFLFPQPLALLQCLVPPPPPEVVEHLAFLDLYIVDNVDTAKDPARSLYKGVIFAGNADAVSVYVKIVPSKYGAAAHQLLAEHDPPYAPKLYWCHEIIVGYTMVVMAELHKSPGSQSIHPRRRNQRDIDLVKRDIGRALRILHAADYVHGDVRQPNIVITNRRAHLIDFDSADLDGVAEYPASLNPKVKWPGPASALVSMPIVKEHDLQRFQWTIEELQGTEPKPKPSAKPSAEVQEQIPYEEGLEMDLQRGRIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9T6</accession>
    <name>A0A2G8S9T6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9T6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="149" mass="16130" checksum="C77C2D4DAD5EC01D" modified="2018-01-31" version="1">MCDDSPYTTGFGGGHKARKLTQWRKFSTARGSDIGVAAIGARRFVSADEGTLNGQHHRGQSRAEYGERGGGSDAAVNTATSSEEEEEEEEEEEDRPRRDREFGGKAPVGLTNSHEAPPPVAQVETRSLTTNPDHPHFRLPSTPAQCVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9W6</accession>
    <name>A0A2G8S9W6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9W6"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="204" mass="22089" checksum="7A825FD5CAAFE120" modified="2018-01-31" version="1">MAGLRMSVVVSATAFLLADSLTLWKSPETQTDSRLWTAATYYAILMHGPPLLAYVYGIVAVVGAATILWSLRDGRAGNLMFDGGSIFLYLTAIAMYIYSVVPNLSTNFSDLPLPFAEPAGSAGALFPKSLREPTLELASSHLVCSVVLTGVLALQAGRWWAEQADIDEDDEEEIDDAADTGAETDRTEPERDSSVRRRDVKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA58</accession>
    <name>A0A2G8SA58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA58"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA58"/>
    <dbReference type="OrthoDB" id="2757990at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38643" checksum="1E63FCCEA9B5484E" modified="2018-01-31" version="1">MPPNSTMDSKVVASHRPPLTVFNAKLLAFCAHCSSSKECQKAHWAHHKSRCIWVAAYTTHAVAPDHSEEGVAFREAFGRFGLSSDRHQVRLVEEYMDVHNWALAALVKALLYKNTKLGHTHWDVLAQPDKAVLVVLKLNPALAGPHPERVGPARSLLLESHALVNFPPTAATAGRWSAELHKCWAESEPRRVMVVTRHCNHPDFVGLVSIYYLVEDTGCTRWAFVPVCRRPEPHLPMSDATLHALRSVTTLCVETTRAGFPMGALSPSFGPTAATRPPGRFVWIRGVWRWRPLFESWADYRPGKHVEFDKVMEKLGPEFVENPAKMERVIEVFRHIPPRELEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA89</accession>
    <name>A0A2G8SA89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_07377</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA89"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA89"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="191"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="450"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="695"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="994"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1040"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116152" checksum="04E01D7DFA8D595B" modified="2018-01-31" version="1">MPAVSAVTPSSIPDPASLKAAVAPAAGQLDVSGLFVADKATREAAAAQFVALAQKEGPSAVQSVGFTDAVVKALGDKKSPAAREGAASAVKALAATPAVKALEPFFITSGVYAALIETFADKMPAVRTAAVEAVKAYVAGMNPWAAGLVLPALLHEIKTAGKWQVKTGALVALNQLVASAPAQTAKLTPEIVPVLAEAIWDTKADVKKAARDSLEKVTALVSNKDIERFIPALIKALINPVEEVPNTITLLSATTFVSEVDSPTLSLMVPLLSRGLSEKLTATKRKVAVIIDNMAKLVDSAVTVRPFIPKLLPGLIKIESVIGDPEARSVVARAIATLRQVGEVPTGDGSDLPPLRLAEERTLASSLVGLYKKAGANPVPTATNVAAVYSSQLAANLVNQKNFDVSEWQTLIPYLAFLTSSPDPNTIANEWAVKSASAEDDEADDAEDEEEGEDLCNCQFSLAYGAKILLNTASLRLKRGHRYGLCGRNGTGKSTLMRAITNGQVEGFPSPDEVRTFYVEHDIDGSEEDTTILEFIISDKRIQATRQEIIDTLASVGFSDERQKSAIGSLSGGWKMKLALARAMLFRADILLLDEPTNHLDVVNIAWLENYLTGLKTCTSIIVSHDSGFLNNVITDVLHLNRFKLRRYRGNLEAFMKAVPEARSYYTLEAQEDYQFKLPDPPLLEGVKTKEKSLLKMRKVGFQYPTQTVQQLYDITLQVSLSSRVAVLGPNGSGKSTLVKLLIGDMEPNKGGETWKHPNLVIGYVAQHAFHHIDNHLDKTPLEYMLWRYQTGEDLEEMMKASRQISEEEEKKMKDGSIVVVEGQKRIIEEIVARKKLKQSYEYEVSFKNLSSSENVWLPRDDLIKRGFEKKVLEVDTREAQRLGLLRPLVRREIEKHFADFGLEAEFVSHNSMRGLSGGQKVKVVLGAATWRRPHIICLDEPTNYLDRESLAALIKALKEFEGGVLVITHNRDFSESLCTEVWAMRDGRLEASGHNWVEGQGSGPRIDKKEGEEEDQYDAMGNKIDTKKNKKLTSSEARKLKKERIARKKRGEEVTDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAG6</accession>
    <name>A0A2G8SAG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAG6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAG6"/>
    <dbReference type="OrthoDB" id="2763430at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="35916" checksum="EDD060022FCF2B13" modified="2018-01-31" version="1">MVFGIGLIPLSITSQSLLTSMTMFGTGRLIFSGIVTFLGSIVFGAVTSAFSVPEVSASSFRPAAVAITHVAGVLVMFIAERRLSSRMLHTSPSCGLDSETPSSPTIATQHDTELKETERTDGLVAQVLSASRTARLGVFGPHQRRVYLFIFAFVAVEIADGISAGYLAMAPPGNPHIGRDDQSDQPMPPLSSPKMLHYLILSLFGKGATTLAFVTTLLSASLPIAECKRHVLLYAAARPLATLLSYAVTVLSGITPTNDRPYIVAMNCFMDGLLVYAELVLRALIINSRGTSRSSLLTRVFLLAAGAFLPSTMLILAFIGHMWYTGRLSSDTVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAH8</accession>
    <name>A0A2G8SAH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_06932</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SAH8"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="243"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1596"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1601"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1617"/>
            <end position="1731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1732"/>
            <end position="1748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL30764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1748" mass="194526" checksum="AC48D0F6E03482BA" modified="2018-01-31" version="1">MLGHQFAYSAAPVRKVREVQFGILSPEEIKAYSVAKIEHPEVMDETTHKPKLGGLMDPRMGTIDRNFKCQTCGEGMSECPGHFAHIELARPVFHPGFIVKVKKILECICVNCGRLKADSSDPTFADRIRHIRDPKARMQAVWSYCKSKMTCEPDEPKDENDGGDQDEPKKGHGGCGAQQPLIRKEGLKLFVQYKRGKDEDEDVKSLQPDKRLFPPHEVYTALKKISDSDLHLLGLSVDYARPEWMILTVLPVPPPPVRPSIAVDGGTMRSEDDLTYKLGDIIKASANVRRCEQEGAPAHVINEFEQLLQFHVATYMDNDIAGIPQALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVITGDPNLQLDEVGVPRSIAMNLTFPERVTPYNIAYLQELVRNGPTVYPGARYVVRDTGERIDLRYNKRADAFLQYGWIVERHLKDGDFVLFNRQPSLHKMSMMSHRVRLMPYSTFRLNLSVTPPYNADFDGDEMNMHVPQSEETRAELSQIAWVPRQIISPQANKPVMGIVQDTLCGIRKFTLRDAFLDWNQVQNILLWVPDWDGTIPTPAIIKPKPMWTGKQLLSMCIPRGINIFRAPDPKSNNPVFDDGIMIENGDIVFGVVEKKTVGASQGGLVHVVFREKGPEATRTLFTGLQQVVNYWLFHNGFSIGIGDTIADMKTMDYIQKQIAERKQNVQQIVDDAYHDRLKPSPGMTIRESFEKKVERELNLARDHSGQYAQKHLKEDNNVKQMVVAGSKGSFINISQMSVCVGQQSVEGKRIPFGFRHRTLPHFTKDDFSPEARGFVENSYLRGLTPQEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDVQVCYDGTVRNSLGDLIQFIYGEDGMDGAFIERQNIETFGLNNVQFEHDFRVDVTDPSGGFLPGVLQAGLDDSSIDLQGKLDEEFAQLSDDRRLLRNWIFPRTDPGAPRYLPVNLQRIVQNAMQIFHIDRRKPSDLEPAYIIDSVRDLCDRLVVVRGESLLSKEAQQNATLLFHMLLRATFATRRVLERYHLNREAFEWVLGEVEAKFNLSVAHPGEMCGTLAAQSIGEPATQMTLNTFHYAGVSSKNVTLGVPRLKEIINVATNIKTPSLNVYLEDDIAKDAMMAKNVQQELAFTSLRTVTAAVEIWYDPDPSSTIIPDDEDFVHAFFAIPDEEVEQKLHLMSPWLLRLELDRAKMIDRKLTMTYVANRIAQSFKTDLFVIWSEDNSEKLVIRCRVLGGADKDEDDLGQVEEDIFLRQLENTMLNSVELRGVPGIQRVFLLEHDKIVVSPNGSIEARAQKEWVLETDGVNLKTVMCIDGVDFKRTYSNNCVEVFNVLGIEAARAAIMKELRNVIEFDGSYVNYRHLALLCDLMTHRGTLMAITRHGINRADTGALMRCSFEETVEILMEAAAVGEKDDCHGIAENILFGQMAPMGTGAFEVALDIDMLKDVIVDHRLPVQTMLAAQADGGMTPGQVAMTPYDSNSPMWAQDVSFKGETAAFSPLAVNGGEEAPASYNLMGYGMSPMSSHGAMSPAAAGYSPSSPNAYSPTSPYLAQSPFAGATSPMGTSPYATSPFYDRSHGATSPTYSPTSPALNLTSPGYSPTSPRYSPTSPSFSPTSPRYSPQSPSFSPTSPRYSPTSPSFSPASPRYSPTSPAQMSPTSPTSPASPASPRYSPTSPAYSPTSPAYSPASPAYSPTSPQWSPSSPSQTQNGSTSRGHAYSTSPSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBA5</accession>
    <name>A0A2G8SBA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin Tsp2 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBA5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBA5"/>
    <dbReference type="OrthoDB" id="2156690at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="48920" checksum="A37B14F70EC278DD" modified="2018-01-31" version="1">MPGPALSVSIPHRPPNTHANAHANGRTAADDSHSRSSSVNSHSPSIQSAANSTRYMLAGMNNNSSGLDPPTLPYGSYRSMSPKNDTPLMGGDGKGASLSVNYLPSKFSANILSGGMKRRKGKGGNPIPIPKTGGGREAFRANESRMAGDGDDEYDGVSFGQARKGRLRWNRFKWVLFVSNLVFSIYSLTGLIATLLIHFDVWTHADVIRVGNRPELIISTIAASLAVLTSLIGWSGILLNNRAFLAVYSFLLWICFALLVTPGYITYKKRTFNLEGKVNAQWSRDLGLDGRLRVQNQLHCCGYFNPFIEATVSQTCYARSLLPGCKGPYLQFERLILKRWYTAVFAVVPAQLAVMVAALLCSNHVTYRFGKGMMPKAYRLNMNSMAVIMDNYANQLAEQYGNDVASEVIARSRSNLQLDSMPNMPYNQSATSSYAGGGGGKYDHFAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBC9</accession>
    <name>A0A2G8SBC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBC9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBC9"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="916"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="610"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="722"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="800"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="945" mass="101709" checksum="7469A6E42CC59D0A" modified="2018-01-31" version="1">MHYANSVLQALYFCGPFRELLLQYPDPSVPDVSPPPPALPVPPPLQPQQPSTSSRKRPVRSASVSEGSFANANPNAPPPVPIPSQPPTLLSALRSLFLHISRNPADKGTVAPRAFIDKLKELNELFRPSMHQDAHEFLNYVLNQIIEEMEVDGQKSAHHPNGVEKSGEDLSTSIATLSTQPAPSTSQTTAQFHSTIVHRLFEGVLTSETRCLTCETVSSRDESFIDLSIDIEQNSSVTACLRQFSASEMLCQKNKFFCDSCCDLQEAEKRMKIKKLPNVLALHLKRFKIQEDVGKYIKLAYRVAFPMELRLFNTVDDAEDPDRLYELFAIVVHIGNGPYHGHYVTLVKARGTWTLFDDDTVSTVKESDIPKYFGDSNSGSAYVLYYQAVDLDLPALGLKSPTPPPEPTTVVDLGPVPVPVGLATAEPSEFSHAPSSPFLHKPPGLNPSVDDLNLSDMSESPMPTPGTAPPSSNHNTSDSLLVAAPTPSYPQLLAPDEPLIPGPSSPTHKEHGSSTLGKALRTLRHPPSLRLKTPNGHKDDHRRSGAVDAHGAMIPPLPTSPRTRRPQTTGSTATASTAENSAQETIPSVPPSPIPPKVFPFPNGSQSHASTREKERTPEKKSNGWFRRKSTRQETAPLPPASPSVPRLARRGSEAAMSDAYSPVTPPTPLPPLTSAALTEPPLAPHKKSAPDLAKSLRREKRGSGNPSSKLPPRPSTAGADMTSSRGLSSRPMSGIAIPPPLPPLPGSPRSPAVGHRAHAAEVFVPVPPVPPKSKSTPSEHGTPDGSPLRPSRPLPDGDPAEREWEQGRRPDPETETEAETEPAPPPPPVRISHSDSQYSSTTHQSHHTAWTLPRPPRHAHADTAPVPGPLLSFGGTGGGGVGDTPVVSPTGQAAAAPDGGAAHNWRRATRKLSFTAPILGFGRKERERERERKGPPPSSSAYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBV2</accession>
    <name>A0A2G8SBV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_05944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBV2"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005825">
        <property type="term" value="C:half bridge of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="23"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="59"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="165" mass="19179" checksum="C72447F9B72BD6DF" modified="2018-01-31" version="1">MYGSAAVQKAKRRTHSRPELTDEQKQEIKEAFELFDTDKDGCVDYHELKVAMRALGFDLKKAEVLKILRDHDKSGSGLVEFDDFVKIMTERILARDPMEEIRRAFQLFDDDNTGKISLRNLRRVAKEIGDRLEDEELQAMIDEFDLDQDGEINEQEFFAIMTDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC41</accession>
    <name>A0A2G8SC41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC41"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC41"/>
    <dbReference type="OrthoDB" id="10623902at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013842839" description="Transporter" evidence="2">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="30721" checksum="935095E4D1DAE722" modified="2018-01-31" version="1">MRLSSTSSSLILATLAVSSSSIALAAPTEPGALDESMAHSPSELQIIAMSGRSEQVASGLDPAPTSESDPIPAVMVEEMLARRGLTDILAVLGGVPIVGPVLVKLLGSLVNSLGLSLDAIQNNAVDAQSTPSLTPDQIRAVANVISGAHNNMQAIMAQQGGLNARGQIAEWDAVSSSPPAPSSSSNTSSATPSSTSSTPASSGNATSNAGSTAPAAPVTLPVPPNSPVPSAVTPPKVIKSPAFFAFASRMIPPVFIKAGQNDVEVSMSGGPAMTLTGNSSSTVTPAGGEATTLASATAVNSTSTSTSTAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCU2</accession>
    <name>A0A2G8SCU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_06259</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCU2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCU2"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="31"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="392"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL31557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="530" mass="58074" checksum="0B56A5A173EEAE0A" modified="2018-01-31" version="1">MTGLITSRVQWAASLDPTKAQVPTEETKYHRKTSIIATIGPNVNNVEKLTELRRAGVNIVRMNFSHGEYEYHQSVIDNTRKMVSLDPEGRPVAIALDTKGPEIRTGVTRNKVDFPIKAGHEFILSTNDQYKDICDDKVMYVDYKNLPKVTAPGKLVYVDDGILSLLVIAIEGENVRVRALNNGNISSRKGVNLPKTEVDLPALSEKDKADLQFGVKNGVDMIFASFIRRAEDVREIRRVLGPDGANIKIIVKIENEQGVANFDEILQETDGVMVARGDLGIEIPASQVFLAQKMMIAKCNTAGKPVIVATQMLESMTYNPRPTRAEVSDVANAVMDGADCVMLSGETAKGSYPIQSVLMMAETCLLAEGAICYPALYDELRNITSRPTETVETVALAAVAAASEQNASAIIVLSTSGNTARLISKYRPSVPIITVTRNQQTARQIHLHRGCYPFWYPEPRGIEAHQWQTDVDNRIRFGLRNALALNIVKTGTTVIAVQGWKGGLGHTNTLRILSVPTDPADLVQQPLGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEE3</accession>
    <name>A0A2G8SEE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEE3"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="6">
        <location>
            <begin position="20"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="90" mass="9960" checksum="878466A06DA6E437" modified="2018-01-31" version="1">MSDALTAPKLDAASQKELEQFLETEQAQARVQTQIHTLTSLCWDKCVGSISSGFSGKEQSCLENCVGRFFDASDYLIRRVEQQRAMAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEF2</accession>
    <name>A0A2G8SEF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06845</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEF2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEF2"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="910"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="102"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL32139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116562" checksum="3A486B259A88B75B" modified="2018-01-31" version="1">MLSTPSSSIACCARRAVCLHFKRNIKTRPLIPEEATQPLKKPKVTKKKYAELPTGRVLPDGTVSPPLNEWTGGLREPVVAHEIRISSIPEETHSLASEQLLHDAEPSDSPICEDSDLIPAKKTRRRRVKSSSSETTPMPEDAEKDASATSKRRKRRTPKQALDDVEVSAPTNPLATEVLDNLNRYPHCILLTRVGQFYESYFEQAAEVSRLLNIKLAKKKWGGQRILMCGFPIMHLHKYLKVLVQDHNRLVAMCEELRSDRPFDAKGTFERRVMRIVTPGTLIDEPFLNPYENNFLLSISPVQVEHSIDGLTASSTSISDAPIGLAWIDISTGEFYTKTTTIGGLRDEVVRISPKEVVLDEGLREDDTSQVRKAVTEEDSFVSYFALPPKPSPAVKGSPDDQLTPDELTAQIDASKEVLPAALTSEEDRAVELLTAFMHANLMDHMPSLASPNRELSGSRMQIDSHTVKALEIREGLREGGTVGSLLNVIKRTVTSGGARLLARWLCSPSTSVAEINARQSLVAFFHARPFLRQDLVQSLRDAEDATRIVQKFLLGRGSFQDLTAICTTVDIWSSIKERILMEKRMEGRGNDHISDAQWASIEALMEKLSDLEWLANRVRAALVPRETAVSDEEVGSDEPFMGSVNPVSSSDPRNTLGVVDWTIRPTFSKRLTDLHSALQSLLAEKDGLERRLQVTYAAPSLTLRASPGQGMHVHVARKTHASQLKKDKDFINETAFAIVGAEKEAFEMLRNEITSQSAILRRNARIIDELDVTLAFANLAVEMRFVRPVVTEGASYHVVNGRHPTVELGLLTSGRSFTPNTVTFTPDSQLQVITGPNMAGKSTLLRQTALIAILAQIGSYVPADSAQLGVVDRVFSRVGAKDDLFRDRSTFMVEMLEASDILRRATSRSLVIMDEVGRGTTVADGLAIAFATVHHLVSVNGCRAMFATHFHELADMLGHDAENHHGHGAFSKIAFFCTDVDEIENGYFAYSHRIRPGVNRDSHGLKVAQLAGMPESAVDVARSALAWLKKRSMQRAESKLDLRTLGQALVSSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEJ5</accession>
    <name>A0A2G8SEJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_05439</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEJ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEJ5"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="159"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="236"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL32194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="318" mass="34857" checksum="2F3573E64F357E78" modified="2018-01-31" version="1">MSRVALSQILSLSFYKDKQTLSRRAQPIPQLKCIGKPCRLYQPEAVRCTNLGGAGSDFDWRCEADLPESLRFGRVEVSCEGWDAPGDSYVLKGSCGLEYRLVEVPSKLRAGDDPSYPSRFSRWFYGAMDDPISFLFILLWIFVLGLILYSAFKSCFASRSRTNPRTTPRPPPRTPSSGWFSGGGGGGPQPDHHDAPPPYTKYPSGSTGAADAGGWRPGFWSGAALGYLGNHLMNRRNQQQQQQQPGPFVRSQGMYDWEAPGSSWFTRPGPSTSSSSWFGGSSSGANRRSGFDNDDRGEGPSNLGRMRRSTGLGGTNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SES8</accession>
    <name>A0A2G8SES8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SES8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SES8"/>
    <dbReference type="OrthoDB" id="3226064at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="619" mass="68328" checksum="2A7CC58999F39DE0" modified="2018-01-31" version="1">MSELLSLPAELLESILIFCNGEGHPLSVAALAQVCRQLRALVYDAADRHLWRALFLKTFDDPRLLHSDVNEDIDWQRAFTERIWASNFLQRTARPLPVSPKKRTLRSNTSIMYPIDSLPHAQDSDLENHVRLLNTLLSVIKSACPSPLHQTVSPSEEDSGLTGAHARTPVYPPGAQVQTPSLNIAWLARTLSHGLPFTLAQRIFSWKVVGYGHNTTHNQCLGQLTAYLGFLPIPTVDAETDDAPPPPSPSRQRRAGKSRAAPRDERETEAQDMSEAAQRARARHRARPRAFCMDYLSRRRNWGPYLAILPRASDDNDNDDNGDGVDVLDALAEVSDSDLDDDDDADYVPLGVDDGSVSSSSASPEPGQLPLVPSTGALPTPEQLRPDWAWLAAARVVAECKLRQHVDAEDIAKLEDWDNLRGGAWVPEHPRPGPDDELGDPEKVEGSDEVAEEWRKYERDWAGAEGIWRRLVCWLDYDDLIHHNTLGGFQDDPDLDEAWIIVPLSLRIAGYSAPSLPHLFPDRPTLHVEGEMGGGGWVGNFDGADEDVRRVHGTVSMLSDGNVRWSTTSTAPGSNEDEWASESVQLGGVGSAMGTLGMWTGAFHEDGDPLGVIWQWRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEV5</accession>
    <name>A0A2G8SEV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEV5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="179" mass="20986" checksum="049FB33ECE1AE78D" modified="2018-01-31" version="1">MFSLRSVDIDGPYALTYPQRRRALLSSSSRLVSDFPRLASPPPPPSPSPSPLPSSPSRYYDYPICHPSTIPPSIPPVNPNTLGLGISFDDDSDLQARLWALEQQDDPALLQLQLQYDDDDSDSEDSDYDFYADFDFDYRYYRHITEDDNRWRSRFRRRVRKMLSFPVRFVLRKRFLWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF95</accession>
    <name>A0A2G8SF95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_05148</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF95"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF95"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL32446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="532" mass="59221" checksum="3434A66C0E115542" modified="2018-01-31" version="1">MSLSTSSISFALLSDLAPTFFRLAVLLSGIIVALSLLRRTPRDKAGNVVPPGPKGLPILGVFPYLSKYPELSLHKWAKKYGPIYSFMISDQQFVVLSDPNVVKDILVTNGAIFSSRKEMFLKVETILVHRGVTASGYNDTWCKHRHIVAKILTAQFEAKEMIRSLLIDGKAGAAAINPQPYASCFALNNILTVIYGIRAESTVSDPVVKEALRISREFIDSYTQQLIYHSPSLAKNVSGAVSNAVDFFPLLRQFPNRMTSRATKLHQDILDFNRPLLADIEGRLKRGDDVPDCLAKTLLLTREEEELDDLDIMMMCGTLTIGGVETISSIQHWFAAHIVGCPDIQEKAQAELDRVCGRDRLPNADDEKDLPYLRAIAKEVARFHNPFWLGKPHMSTEDFAYHGYFIPKGTVVVGNTWTMHRDPVRHPDPHMFNPDRYANDTTSSADSARLPDVVERDHWSFGMGRRICPGVILAEREVFLGLAHMLWAFKIAPIPGVPIDLNEYDGVSGRSPVPFVVSLTPRNASVAEVLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFN8</accession>
    <name>A0A2G8SFN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFN8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="300" mass="33258" checksum="6AF7304DED319FE3" modified="2018-01-31" version="1">MPPKRQRPNSLSSNHDDEKRLCDADPRAPTAPSPSPRYLGSVSVSDSSNDEGQTSTVASEQGLWDLGIVDVDEEDVGDPDKAEGGATADQHGSGVHEPSLTDGASGEPLLGLHYNLVPHTSKINTLLRGAVGECYVKLTDVPDNADWNSQLHLSALDGRALVIVAFGSLSFVHLQFGWMMVPSFSVTVELSRESEKDALQNILDLAENRHEEATRHLRTFRAAHDEHSHFLNMFDCTRCTRANQESRRCGINEFATGDFVRVVMRCMKVVDEDTGRVRVEFKLRRLDLLVPLSREQDIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFP3</accession>
    <name>A0A2G8SFP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFP3"/>
    <dbReference type="OrthoDB" id="2762735at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013560407" evidence="1">
        <location>
            <begin position="19"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="400" mass="44784" checksum="54A53E65F979B1E2" modified="2018-01-31" version="1">MGTTRLDFLLALLELARAEGDPVENPSPWSWPQWKKLLLAVGFEGPPPWTAKATFGQTRIQEAEREFCKVFILAFHVAGDTPNARREYAYSLEEGDAFKGMCHLGRWSTRVKTIVEGEVDRILKEARLITGGARTVCVLVCVEILSNIPDVIAEQIFQIGLRNPHVVIGILTKGLLGKRAYQAPTEPAYAWLSYVISAFKARWQALYNTRMRFVDQIPRTIYAACQDVSNAHCCITDIYQYLSCLHALLVELDFYVSDNRLSQQDHYRNLLDAIARLAEGSDLNGKRVGVCLPPNMTRALDNLEADRVDTVLGAVAACRKLIDCGPDYVLEDFPEEFNAFALLSETKLSGILNWEASSELRDACARLEADPGLSESLTSEWDDDEIAACLFTISTLPRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFQ7</accession>
    <name>A0A2G8SFQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFQ7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="112" mass="13354" checksum="0739B8973FEF1094" modified="2018-01-31" version="1">MCESMNLYRCLNGPKRENRDFMETLKIKQRRVMSVSDLDVHVALQPRHLIHIHLRKVLMHPKLLLHGVLGCRSRLHHDHLLDALQWLRLRRHPRIGLLTSFRRALLTNPVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFW0</accession>
    <name>A0A2G8SFW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFW0"/>
    <dbReference type="OrthoDB" id="2756141at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="377" mass="42570" checksum="3B4C68FEF453A3E7" modified="2018-01-31" version="1">MSVQSKLTFMSLPLDILQEIEDHLDLLALLSLGGTCVYFRDRVAGTLAFERDVIIEHYWASAKVLLPMLTRCHAVISGEAALAFVMRNRSLLGRELEICVSAQHSDDLLSDFDAEPLVQCAWGPNAWPYMDRDQPTAYLYLSPSGDPIRIICSHTDSPFTPMSYYPTTALYNYMDEFSFGCAYRDLTLNHSAVSPFALTDEEEVRVLHIAARGGFRNSNWPAEVAVPPRPFVLFNVLGVWDNLLTVDLVNTVCLRSTYQCAGQPRFFGDRGSLVDFFEPDMVDHAIMVHWHHPPYGRTAIWRMPGLDCDYGCGSGDYLLRDVLSDVCMVGQPMHYGPFTSAVLRRVLVGESQRDRIWNSMPDNIRLETRNLPWCSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHB3</accession>
    <name>A0A2G8SHB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHB3"/>
    <dbReference type="OrthoDB" id="2765668at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="180" mass="19228" checksum="F3CFCFF7EB27897C" modified="2018-01-31" version="1">MADDSLPTPAGRTNDTVHTPPMLVQTPQNRLNHTESRVVFGAPPPRVLTTAPKKPPAKRRKGRTPTARAATAVSNKNNGVGKAKTQPIRAKDSESSQSDVLTTQSLAAAEQQPVMPTSLVLGRAKRVRVATARALDQSPDMSAANKLKRRTDAISGDAGEGADQAEEVEHRVKRRNTGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHJ6</accession>
    <name>A0A2G8SHJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHJ6"/>
    <dbReference type="OrthoDB" id="3228154at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="437" mass="46239" checksum="E27D677651F877A8" modified="2018-01-31" version="1">MQLLFSSSPTASPKPLSSRTNSLTTRSLKVHFKLPVIKKASPTVSVTNANAARASTALSTSSEARPSLPVLHEVLSPTANSVAFPSSPIPCPSRKRAHSDDGYDSRDGGDEPVDVAALEIPSRTQGSAIPFHRRISHIDILRRRSKSCLAASYFHSDSTVPPAQPVAHVPAPQPFPTEDIDMPDALPEPPVKRRPASRRESMSAGNPSGRTVRKARRVVADAQFLASMHSSIALRVRTSIENGATAPPRGSDEYAAQDALLVERIWHTLVDMGYKPVPLDNALSSPPLSPSPTPVPAPPTTTPTSPAPARSTPSPSTPSSPSTPSRDAAREAAERAARRTQAVSASPFSFERVQDIASSSHGGVLPGPQLVATLIMRHRERAATRPKRRALGDGPRPQPVSRSPLSKSAMASPPPSPTISPSPSVSFASVFAQSSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHK0</accession>
    <name>A0A2G8SHK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHK0"/>
    <dbReference type="OrthoDB" id="2753218at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="717" mass="80236" checksum="F2233328C422514F" modified="2018-01-31" version="1">MLRLPVWDLVLIGDPGGDLEADYTTFLLHATVCHVFRIQHLSFSTPRTQRSPPSKFASSNSAILMEQGSSNIFLPPDFASPLSAADRASLEGLSKDEIQAWALRKSEEYRLLSYDMLSLHNAAAPIHTLPVELLRKIFSMTWTQWSRKGLRPISVCRRWRTVYLATTEFWAEALAALGPTFIERGHHGGQTFSISDPGYSDMRPPPQFATMLLDRSWPCPIKLHARWEALRGAPILPTQFVLHTTVFPHPIHVVGLTIATTLLYLHDLYRVLNVGIPALEELDVRAREMEPPDLVRTLLTLPPVPDGNLPCLRILHLDPAIFFPLVAVRALENVYLGSAQGEDAPWTHPAESESRSLIRVLSRCHKLESLHLEAYERSRWWPPLGDGASGTVQLPSLKKLSFGSDIETVEAYAHSVLAALDPCIPSTASVHRGPLTPDWPDNLPEFMPDYLVEHHPFDTVILSIATSYPRGRKWSIHCLAGGSPRLEVWFKATQTLGELGIEHVFRTAHVTHLEIIQDFRTHPRSFTRTSKPSTLVDDWAATLRAFPHLTHLTVRGADTPDAVVDVLGADAGHSHSELLASGRPLCPALRYVTVGWRVPREIVPEEADSSCDPATYRKHQDVGPRVEQRCSVLQLAFERRTSMKAQGLHALEFYEYELRGDDAYGVAGEFGELISGSRRDDSDLPCLERLREVVGGPVVYRGYLLKTAVERQWNANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHQ5</accession>
    <name>A0A2G8SHQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHQ5"/>
    <dbReference type="OrthoDB" id="2800059at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="226" mass="25516" checksum="337081F8A6269AD6" modified="2018-01-31" version="1">MGHKYSIPKVMNDALSRLKKYYPTTLTAWDDVTTREGYVTAQPIDAFEAVRLARLTETPSLLPSALFACCENMCSISVKDDCAPPEHQLLLYGLSVQDSRRLIKGRENLTLGVVERLLKLVAKHSSLPSDYRASHRACVEKVIAILNLRTLDGSFFKKTRHHAALQPLCEWFVNLTDTAATGRQGLQCESCLKYLRRTDEKSRGEAWSHLPETFDLHVNDWPSAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHR8</accession>
    <name>A0A2G8SHR8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHR8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHR8"/>
    <dbReference type="OrthoDB" id="2367075at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22355" checksum="A9852FBC20CF3C60" modified="2018-01-31" version="1">MFALPPVNSAYGVEGSSDDNPIQLEGVTEDEFKALLWVMFRSGYGSSRTLTQPQWVSVLRLSTMWFFKDIRTRAISELSKLVSTPAARIVLARTYNISGWTEPALCALAQQDAPLSAQDLEALGWDAAAKLVQIRESVVFRVVCVRVQLLHRRARPHRYSRAGRRGRWDGGARPRAGGAAVGGSEGGSGWRRSSRRVRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHV7</accession>
    <name>A0A2G8SHV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHV7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHV7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="159" mass="17591" checksum="10C9A3E966346DC9" modified="2018-01-31" version="1">MTSAVESMTIPYFRTQPLPPPSNQRIPEDATTEHKHAPQTLPVYPVGDLSRNQFLNLWAAGIPVVLTHAQKKFQGHWDPGYFAAHYGKLWVTPIDCDTDEQVPRMAARDFFALLLETSNQQATLKLKVGRSAAICGATDQIFDAGLATEGGLQDDIRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHY9</accession>
    <name>A0A2G8SHY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHY9"/>
    <dbReference type="OrthoDB" id="2721240at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013923540" description="GH18 domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="42"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="319" mass="33242" checksum="0555934C7AAE0C61" modified="2018-01-31" version="1">MFSFSRMITSVSAALALASVSSVLAVPVPNQLASRAVSIPSPAFVVYTDRFVSADVLPAVDQIKGFNVVALSFLTLKGALDQAGAFAALAPDVRAAKKAEYAQAGVNIIVSAFGETDKPTTQGADPVATAATFSQFVITNALDGIDVDYEDLDAMNKGDGAAETWVSTFTTTLRQTLPQGQFILSHAPLAPWLAPNAQFAAGAYVTINKNVGALIDFYNIQFYNQNLYGDCAGLITTAGAPFTGSALLEIPKNGFDLNKLVIGKPGGASDATNGFIDPATLGTCIDQAHAAGWKGGVMAFQFPNANADWIRAAKGSSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIL5</accession>
    <name>A0A2G8SIL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIL5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIL5"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052527">
        <property type="entry name" value="Metal_cation-efflux_comp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43847:SF1">
        <property type="entry name" value="BLL3993 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="138" mass="16004" checksum="051C73E98C913DCC" modified="2018-01-31" version="1">MSALGTFLGFAGGAMRMWCHHALGRLFTWELSVRENHKLITNGLYSLVRHPSYTGLILMTCGNIIYLASERSYFVEAELWNTGLGRAIGYTLSVYLTWITWMLCARARQEDAMLKREFGAQWDEWAERTPWKVIPFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIW4</accession>
    <name>A0A2G8SIW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIW4"/>
    <dbReference type="OrthoDB" id="2753716at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="265" mass="29774" checksum="4F690A03800A7253" modified="2018-01-31" version="1">MSTPKTVFPFTRLYGTIEIDHAGMVQGLKDLEADEAVRGIVPKKYLVWIHLIGTLLVDWDDPCSYRVGIVAQSPRRVDDPRYLTANLFVPIFPNEDPDKERPCVYPDGPHSSSTPFPRGDCSHWTASEVWVAFKRVPEGLDNASAYRLPCEGMSLLRATYSKDYAHIRGVKAQQAAARRSSHPPLTEGPSPQVSETRPSRDGEGGTTLRADSDAPPMKWADDPYNDTFVPLAKLSLDIGWTSQAESLPDIYSFFEEREQIKRWDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ54</accession>
    <name>A0A2G8SJ54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ54"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="13098" checksum="E17275DEA6803FDF" modified="2018-01-31" version="1">MTTSWTKGISATSSRSSSTAIYCTCSKGQTSSPSYARVLPPPTATCASPLTTPTLSSCISGCSAQAGSCGPMRGLTRISPPRIPRRHEVQYRDFSTRGSPDTRSRELADSVSLRSWLRVVLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK55</accession>
    <name>A0A2G8SK55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_03851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK55"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK55"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05581">
        <property type="entry name" value="STKc_PDK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039046">
        <property type="entry name" value="PDPK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="122"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL34140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="789" mass="87078" checksum="DC433F25B6DC53F2" modified="2018-01-31" version="1">MLKLQVSSRSPDTTHPTPTLAELSRNASVISSSSSNSSCPDLTHTTPVRPRPLRNFSAPRTNLRSRSPQSPTTPHRTRPPAYLTRELGYPEDDPAPLRPPASRTQSKSRNSSVTGRMTVDDFEFMEELGQGSYSTVWHCKLLATGQEYAIKRIDKAHLKRHQKEQTALAEKNTLVRLGSGHPGIVRLHWTFQDEWSLFFVLDLARNGELQTRISQIGSLSIECVRYYAAQIVDALGYMHSKGVIHRDLKPENLLLDDALRIKITDFGTGKLLDSGGEPTKTFVGTAQYVSPELLEHNESSKSELNMTPSRPATCDDWQKIKQLEYDFPEGFDEQAQDLVRKLLVREPDQRLGAGSTGSPYDMRALRSHPFFAPINWSTLWSDPPPPLEAGLVKKDAPQSSNISIRLAWDALDENAIEDDDQDELDDAVSWTSNGEGTEPNHSPVRANGHTPHELIGPFDERRTEVLPPLPLSNVEEERNTSADGVRFISPSQSSSIPEDEIRDTVNDVLDIPVPTRSSPIDVPRAPRPGSHSTGSITSSSDGSPVDKLPVPSDESSRGRPRAQTPIQGNGLHDPELYVTSLAFFRVFPVPLSFPFCFDKLTGIAERRNSLMLPGEHVVFNTSVEPGGPKRRASRLLAMAVTPKKHQKQQQQRPRQLILTTHRLLCVKNKPGRAVQVRTELFVKPPSGKDKDKDRDLRHLVSSIEPKGEREFVVITPTKTHCWVAGSASIASTWIRKIQEVIETNPPAPATSTGLANGTSSSSTSAAATFANGLASAIPIGGRLRSISRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKD6</accession>
    <name>A0A2G8SKD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKD6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKD6"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013903339" description="Transporter" evidence="6">
        <location>
            <begin position="28"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20236" checksum="39C1C7551CA9073B" modified="2018-01-31" version="1">MAASAALPGLVFSFAAMVLLIFASVSAPTWDSISFLDAPQGRTLTVTHFGLFGYTGSETTVGWYFPPRLGDRTLNDVVFHNLTYVLILIPIGAGLSGLAVLFGLCGAAYHRAGTVFMTLTGALAFLVTLVAWVLEMVLFGTARHHMRDRGIDATWGNANWLVLGALVALFIAFFASLCGSFGRYRKSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKZ1</accession>
    <name>A0A2G8SKZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKZ1"/>
    <dbReference type="OrthoDB" id="3346544at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="14438" checksum="80A5788007B27253" modified="2018-01-31" version="1">MHIIESGLMYTVSVVILVVVYLASNNAQYAVSDCIVQIIGIAFNLIIIRIDQGSSIDSEASFISQPSTVDKPERSRSLRFRFSGQAATCTSVMQVGANDGDYAGQNHAIAMMAFKPGTVPSLPDKPGAEESIGTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMH3</accession>
    <name>A0A2G8SMH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_02749</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMH3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMH3"/>
    <dbReference type="OrthoDB" id="427800at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1030.10:FF:000002">
        <property type="entry name" value="Anthranilate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.10">
        <property type="entry name" value="Transferase, Pyrimidine Nucleoside Phosphorylase, Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285:SF2">
        <property type="entry name" value="ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glycosyl transferase family 3 N-terminal" evidence="11">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 3" evidence="10">
        <location>
            <begin position="102"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL34962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="377" mass="39797" checksum="03E095ABFF8FDF82" modified="2018-01-31" version="1">MDSESSCSSSPTMLPPISQDTFKALLGKLVKTPEYFTSDDLKVSLECIFTPDVVLPVQIGSFLTALHIERVERRPEYLAAAANVLRARALKVAVEGIEEDFVVDIVGTGGDGHNTFNVSTTAAIVAAGAGARVVKHGSRASTSSSGSADLLQSLGCYFTPPSVDNPLPISRIPFTFIMAPQYHLSLAMIAPYRKALPHRTMFNVLGPLINPARPRGMVLGVAERELGPTFAHSLADGGVQRAFVVCGAEGLDEISCAGDTFAWELHLDGSVTERTIHPRDFGLQAHPLSEVAGGPPEENAATFRALLQSGADIPAKLTPVLDFVLMNAAALLVVAGIAADLKDGVAKARESITSGKAWNALEQFRDAGVAAAAQVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMK8</accession>
    <name>A0A2G8SMK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMK8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMK8"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="3">
        <location>
            <begin position="171"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="376" mass="41409" checksum="97829C3A22CD4E46" modified="2018-01-31" version="1">MWALVEAAQVIPQIHARAREEFRSGKTQSIAFRKEQIAQVGYLVKDNEDRFKDALKRDLGRPPLETEFLEFAQVYNDVAKAYSSVDKWAAPTRAEFDLGVWAMSPKYTAEPKGVVLIISPFNCPIMLSLSPLVGAIAGGNATVIKPSEHAPATCALLVELVPKYLDPDLYRVVTGGIPEAKKICVAPEYVLVPAHLQDAFVDAVKEVYHSFFPDGPETSESFGRIVSEAHTQRIKNLIDDTRGSIVFGGGADMSKKYIAPTLVRDVPRNDSLMREEIFGPVLLVIPVKDVDEAIAFINERDHPLVIHVFSQDKAFQKKVFSRTHSGSAVANDTMLIVGIPGLPMGGTGESGYGYFTGKDMFDQFTHKRASIDTPGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNS6</accession>
    <name>A0A2G8SNS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_02154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNS6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNS6"/>
    <dbReference type="OrthoDB" id="3542292at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL35427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="794" mass="90551" checksum="E3759D0C18F2A5AE" modified="2018-01-31" version="1">MAPSLNHPAGVTFIDEHHGPVHTDASTYYGGEERFSRGRTYSQSFAHGYNPKRPPAFEDANHQRARRMSHDEKGSAPRRFLIDVEETIRVVLEQEDTDGDFQISVTDAGPKMMALGTATSNGFKSFDIRGTYMLSNLLQELALARDHGRKRIVLDEARLTENPVDRLSRMIKHSFWNALTRRIDGDGLEIICADPKNRTGRVNPRIYVPHGEPAMAEYYRKVAREKPHLNLDVQVLPPKPDDPQFVKSLNTKPGILALAMQEASDGKGGKTLKGIPFIVPGARFNELYNWDSYFISLGLLVDGYVNMAKGMVDHFIFEIKHYGKILNGSRSYYLCRAQPPFLTDMALQIYNQLDRSDMEENRAWLKRAIQAAIKEYHTVWVAEPRIDPKTGLSRFRPDGVGIPPETEATHFTHILEPYAAKHGLSVLEFSEKYNAGILKEPELDEYFLHDRSVRESGHDTTYRFEKRCANLGTIDLQALLYKYEVDIGTAIREVFDDELELEEDFALAPFPPSVEAYRDTARWERCKARCQTSEEWFARAEWRKGIIDKYCWNESKALFFDYDTVQEKQSLYESVTAFWTLWAGCASEEQCWKLISQSLKKFETLGGLVSGTEESRGKISLDRPNRQWDYPYAWPPHQIMTWVGLERYGYLEDAQRLAYRWLYMMTTAFVDFNGVVPEKFDAVKLSHLVDAEYGNQGVDFKMVPREGFGWMNAAYQVGLTYLSTGMRRAVSACTSPEVFFGEYVNPQQQAHGYAAAVNDPLGLAMDTLRLSSPVMSPVDVSARDVPEQELAAQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPJ2</accession>
    <name>A0A2G8SPJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPJ2"/>
    <dbReference type="OrthoDB" id="3249754at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="460" mass="51273" checksum="4E975938D6920673" modified="2018-01-31" version="1">MSCSLCRLPFTPSPSSMAPRWPPDGILSDKQLQYMKHAVGMGQYLVGLVVNLVHLDNNMFTINNSPVLVTIVWETGNKTFIALHTHCAMFFRHNLGLTSDCPGSLIECSLIDTIVGPTQGGAHAGRLNDVDYEGVLGDGSERVDIESLWSKGPSEGNAHFDWQEWKQRGLEWTAARPDVFPRFRPTILEARLSSVGERMATTDIITTQSLDILHILLPYLSNKSYVNLIATCRTLRYHALTTFQPHARVRVLSLGWAVPLESEYINYVHRMRPDLDIADSQPEPATEGGTQPPIQSSPPSPTDGTSPVDDAGLETRLDAMSLSLEPMSSHRASRTAILSQLEMAHAAHSPVHADWLHYLSRVHRTPAMRARRWVWALAEAVAQVYRRKRAEGPFADLEPDDDDSDEEGGLDPEQREKWGKLPRKSDAWNAYAQSVMQQLVMRRLVQGAGAGNGRGPRFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPT3</accession>
    <name>A0A2G8SPT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Urease</fullName>
            <ecNumber evidence="3 11">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_02482</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a nutritional role via nitrogen acquisition in the environment. Contributes to the central nervous system invasion by enhancing yeast sequestration within microcapillary beds (such as within the brain) during hematogenous spread, thereby facilitating blood-to-brain invasion by C.neoformans. Affects fitness within the mammalian phagosome, promoting non-lytic exocytosis while delaying intracellular replication and thus reducing phagolysosomal membrane damage, events that could facilitate cryptococcal dissemination when transported inside macrophages. Urease activity is also associated with the regulation of key intracellular metabolic pathways, including melanin biosynthesis, polyamine biosynthesis, as well as intracellular levels of proline and reactive oxygen species.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="13">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPT3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPT3"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050069">
        <property type="entry name" value="Urease_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009682">
        <property type="entry name" value="PRK13203.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33569:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 13" id="KW-0533">Nickel</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Urease" evidence="16">
        <location>
            <begin position="405"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14 15">
        <location>
            <position position="596"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="13">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="548"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="636"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="12">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL35752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="845" mass="90469" checksum="6DC6FFAD6AB95531" modified="2018-01-31" version="1">MRISPREEAKLLIHQARSRPLQAGSLAQKRLARGLQLNQTEAVALIASQLQERIRDGKHTVAELMQHGKTMLGRRHVLPGVPALLHEIQVEGTFVDGVFLVTVHDPICTEGGDLDAALYGSFLPVPSNDVFPVISAAEYSHDNAPGAIVVKPDRIHLNRGRERVKLRVTNNGDRPIQVGSHYHFIETNSALTFDRARAYGKRLDIAAGTAVRFEPGDTKTVTLCAIAGAKIITGGNRLATGVVNLSRTDEIVKNLVQRGFGHSVEPGALEVSQDTDIGRDAYVAMFGPTVGDRVRLGDTALWIEVERDETIYGDEVKFGGGKTIREGMGQATGRPAADTLDLVITNALIVDWSGIYKADIGVKDGKIKGIGKAGNPDIMAGVHPDLVVGSATEAIAGEKLIVTAGAIDAHCHYICPQQVTEALASGTTTMIGGGTGPSSGTNATTCTPSPFYMRHMLAATDGLSMNFAFTGKGNDTGVDALEDIVRSGAAGLKLHEDWGTTPSAIVSALDVGDKYDVQVNIHTDTLNESGFVESTIAAFGGRTIHTYHTEGAGGGHAPDIIVVCGQDNVLPSSTNPTRPYTGNTLDEHLDMLMVCHHLDKSIPEDLAFAESRIRAETVAAEDVLHDTGAISMISSDSQAMGRVGEVISRTWRTASKMREFRGPLTTLGDQDGRDNGRVKRYISKYTINPAITHGISHLVGQVAVGTLADLVLWKPENFGAKPEMVLKSGVIAWAQMGDANASIPTVQPFIGRPMWGAFAASAALNSVSFVSEVSILSGTVASYGLKKRFEAVKGCRKVTKKDMKWNDATPTMTVDPESYEVRADGELMDIEPATKLPLARYYNIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ81</accession>
    <name>A0A2G8SQ81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ81"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ81"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="643"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="4">
        <location>
            <begin position="42"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="3">
        <location>
            <begin position="261"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL35873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="820" mass="87724" checksum="02F859588E802FDF" modified="2018-01-31" version="1">MTGPNPTIGWEGRIRVNGTTYLWMGKDGTGLADITNIQITPTRSIFVMQAGPMNVTITFLSPVEPDDWVKQSIPFSYLSVEAQSLDGNSYPVQVYSDITAEWASGDRTGSVVEWGNATNTGSSIYHKIQLQNPQQNVENANQAQDGTVYYAMPTTSGGLNNTATTAFGPISPKFTAFASAVDLGTIQSTASPVSWSIGYVRDPSISYTTPSGTVQQRSPYYVTQYQNAEDAVDAFTSDYSAAHDRAVALDQKIMAAAANISSQYSDLVSLATRQVMSALDFTVGTDSAGNVVPGDVKVFMKNLGTDRRVNPVEHIYAAFPMFLYLNASIGGALLQPLLEAQNGLTSQVYAAMDLGTAYPIASGSRAVLNEGVEQSGNMLVMALAHARISGNGTLLSQYYNTMKRWADYLVSNALQSDYQTIQDGSITNLANTALKGIIGVKAMAEIARALGEESDAVSYDNKSSSLFNSWLSLATSSDQSHLLGGYGDQQSWSLMYNLFADKMLALNFVPQSIVDMQTQYLDSLLATASEWGLSTDSESEPYGNAGEASHDMVLHFAYFSFPRPTRSSAWTLFTSAVVSNTTPCAWGHVFPSCPHVSQDPGEIFPVLSASAPSVSNQTISGGSTNGGQSNARVGSDSRTNTGAIAGGVIGGLALIGIVAATVIVLRKRRKNKKMDTAEVVEQTPHCPTLPPHSQHPSSDYISISTPSDMATVGFAGMGEGEMGAYESTPISLSPHLSTKARHGATPNRTHHSEFAPSESVTTSSNVGSQTGSASSRDPLWSRGATSRMDVVGLREEVEDLRRVVHEIRVERLEPPPEYAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQL6</accession>
    <name>A0A2G8SQL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQL6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQL6"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="105"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="204"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL36059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="300" mass="32503" checksum="50E63F3F544603AB" modified="2018-01-31" version="1">MSKTVKDLTAGTAGGIAQVLVGQPFDIVKVRMQTAPAGTYKGMLHCAGGILKNEGPLAFYKGTLTPLLGIGVCVSIQFGALEWSKRLFAAQNARNRRGGPDGATLSSGQLFLAGSFAGLANGVVSGPVEHIRIRLQTQSATHPVYAGPFDAMKKIFTQYGIAGIYKGQVVTLWREATGYGIYFWAYEKLMQREMQKKGIRRDQVNPANAVLFGAAAGYALWAIIYPIDMIKSRMQTDGFSAADGQKYKSTLHCVRTVWRTEGLPAFTRGLTPTLIRSPFANGATFLGFELASRVLNNLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR24</accession>
    <name>A0A2G8SR24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR24"/>
    <dbReference type="OrthoDB" id="2751164at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="303" mass="33700" checksum="F8519EC64F074549" modified="2018-01-31" version="1">MSSDSDVAEIIAEQDSLWVSLLCSYAAFTFISYDWVLNLDEEIKLFWRRKVTAASILCDAYMYTIFVLQLLIYIFPALFSMLRVYALTAQNKILALVTLFFSLGPLYANAVHYGWEKPEYLGPEYGGCFVVDDATHQMGVICKYVIVITLVKTFNLARTSKGLIGSSSLSTTLLYSGVIYYIPLAILNILHTILTETGVNQVLRTSSLVSVFIDPVTSVLACRFLLNLRRVEEGRTRTVDESFELTPTLHFSPDPASTLPPFIASMGELVDMGFTHPEDLDPSEDNSEGEEITFAESGASDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR56</accession>
    <name>A0A2G8SR56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01917</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR56"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR56"/>
    <dbReference type="OrthoDB" id="2655894at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="430"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="477" mass="52120" checksum="7F58A9ABC992B1C2" modified="2018-01-31" version="1">MTDAPGPSRQKTKPSGQGNNPKPGATHGSAGTSAKQVGPQLGEPGEPGAPGEPGATKDTQQQEPHHEHQPQQQERQFNEGVAQGCIDLVESYRRGSKNRGETLLLLAKKLGLQGTDDDDPAASAAFNTYCAQVNEIDLSRKPGESRGGSQGPTAGHGDSDDENRGRSQTLRQPKGKKRAARTRSRAHSRSSGRRSDSRSVSPLDLSDDEPSSSKRQKPDPSKFAWAQSSKEAEKDLRPEVSQTLAMLRCYAVDIRFARTNLINSVGAPEFPEAEWGNILRGKPVDLNHVFSGQYTLGQDEKHVEKLGPVELSYRAVTPAKVIKSAGDWVIAWQRTTAAVIYAFPHRKQELEAYHNHIFGFFGAIHSDYHYRILDYDRAVRKKVAAMRTLLLTDIHEFANLRTLHIDSIGASAATGYPSKRRDTATRKTTAASDEPCKRWNRGACNATDEACKYAHRCSACNAAGHPATGCPKDGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRQ9</accession>
    <name>A0A2G8SRQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_00145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRQ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRQ9"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="83"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="697"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="853"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="763"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL36456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="900" mass="101801" checksum="8C3832D4601264B8" modified="2018-01-31" version="1">MSEPPPPETMAESAMQEDGQQPPESQLSEGILNALRQLQESSLPPAMASTPTPTSTQPNSQDPPRPTSVPAPEPTPPPQSEWDQLRAQLREKPVDADRWQKLVDLAEDSVDIEKIKETYEGMLETYPNTPSVQIAYLRHFLDDPSHFGYAEQLFKKFLLKTSPSVDLLKFYLTYIRRITTGPNARDVIRKCYDFALGHAGQDKDSYEIWQDYINFLKAGEYIMDRDLILFCLFEFTTSTTWEEQQKMDAVRRAYQQAVQIPMENVKRLWEDYQDFENNLNKITAKKFIADLQENHMQARTVLNQLQEHLTVLFPSLPAGKDKRPSIWLPRPPTFNSGDKAIVARWRLYLKWEEGNPLEIEEGNRSAFLQRVQSVYKKAIVRMRFYSEIWYMAYAWTNSVGKTEEALALLKAGIDANPASFVLNFAYAEALELQGNFTEVHATFDKFLGTLRKDLEALESRVNASSSSNGSSSSQQPSQTQNNGDASAPASQQGPTSNNSSFNTQSSDEKPPKNKELCDKRTDYGIAWIVYIRFARRAEGLRSARNVFGKARRDRWTPWEVHEAEALMEYHCGNKDAPLASRIFEKAMELYGDEVEFVLRYLGFLISINDENNARALFERVIGTFPPDKARPLWERWSKYEYQYGDLAAAHKLEKRMAEVYPNDPPIKRFAERHKYSHVDSIATRDLGFVLSKSGNLRPNGSSGLLGRSDTLQSISSDRDTTAKSATPVQGSSSKRASSPDHRRRDESRDYPSKRVRASSPGPRGRDRDRDRWDGPPPHRRHASPARDREWDRDGPPAPASRGRLKEEKEEDKSVQLPNVLSWFIGTLPAPNSFDGPVFRTDDLMQVFRNAVIPSSSGAKPRSPPPPPRSAAGGGGGGGGRPPPDYGPYQGPGSSGRRGRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS52</accession>
    <name>A0A2G8SS52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS52"/>
    <dbReference type="STRING" id="1077348.A0A2G8SS52"/>
    <dbReference type="OrthoDB" id="205198at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF14">
        <property type="entry name" value="NSE3 HOMOLOG, SMC5-SMC6 COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="2">
        <location>
            <begin position="18"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="343" mass="37441" checksum="FFA2D46A08BDCB27" modified="2018-01-31" version="1">MQDGPDEDDGGERGDGEIEKKARDLVRLALFHEQRRLPLRRDEISKKVLGSGTRTFNAVLASANQILHKTFAMELVEMQAMPSDKDMSDKDADLLKNTGVKKKAAPTGTKSYILRSLLDPALIEQACAPDVEIRELEQKELVDENEEFAEDDNPIGQRSTGSIFAWHDSDQLASTGILYVILALILVEGRVISDNDLRAILKRLQLPASTPIPLSSQATAQSVTIDAYLAQLTRQGYIEKHRVGTAAGKGGNKRARATQAPAGTDDHLQAFEWRWGPRALTEVGERGIAEFVAEFMAGQPGQGEDGEEDAVGASQDEGTQKRVQIIFKGIERAAAGGQLLEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST20</accession>
    <name>A0A2G8ST20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_00606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST20"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST20"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="4" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="217"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="363"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="576"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="737"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="878"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="582"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="754"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="901"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="953"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL36916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="966" mass="102521" checksum="0BE70B70A8C413CE" modified="2018-01-31" version="1">MSDMSTFDSLISQLTRDVQRVQPKDALQFCARWFQSRLDEQRTRTRDALARHPSLATGLPQDHYMDTPLSPTAGAPGGPTSISPFSQSFPQQRSSLQNSMSNASPFGTLNVPGNALLDNTPRTLTPVSPPSFQLEGEDLPSTPVSAPNPFASFANGSISPNPGEFLHPPTATILARRTSVSAESIPVDSETHEPLPVFPKTDDQLRRIRASIANNFIFRDLDEEQETGVLNAMQECKVVTDDVVIRQGDVGDYFYVVESGLLHCYIRPEPLPHDWLSGSVSQSDMIGTPGYHPVFGRKVAECREGSSFGELALMYGHPRAATVLAIEPCTLWSLDRITFRTIILKAAHRRRTMYEQFLSSVDLLASLEPEERSKVADALVSRVYEDGEAVVRQGEMGDTFFFVEEGNAVVTKIQNGGHDVVGHLKKGDYFGELSLLRLEPRAATVSAVCLAGTDKLGHSATGRQCVLLPKTPSICGRWKATEVIPLPSTHTLLTTSRQNRVQPAPAPCATTTTLHFIASPFTMPIPKSGAFHVVKAGVLPRAGAEEDLFGARGLLPTLNLPTLSIPGVGDLTSVLGLPGPDTSTTSTSSTTSAPAETTSNTIALTSSDSATSTTPTSTSTSTTASSTTTSAASSTTPLTSTSDPPSVTSTTPTSSLPPTVTVTSNDTASAAATSQADAAPKSFLQNKALSVGVITAATLVGIVLIVALATWVVRKRRKDRIDQDIIDFSNAGLVNEHDSEKGGAGGFGALGGNVETSPTGSRSGSSLGHGNTVPPPVQSRQMYQDMSYGAAAAYGMPSRQASNTQQTSPYRGAYGPYPTNTYQSPSATYNTTYSNWGYGYSAGAQYDQAYGGTEGAYSGYTDSRANVNVAGYGAGAQQQAAPLQRRPSAQRKPAPQLDLASESTATQPLVTSPEPISGTTRATPPPPEKDSYPKLPVPGPLPDQFGASLGSPTEHEEPRRLVVRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STD2</accession>
    <name>A0A2G8STD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STD2"/>
    <dbReference type="OrthoDB" id="2355659at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="314" mass="34820" checksum="BFEA174F5B7BEA73" modified="2018-01-31" version="1">MSLSRSLSLAGSLVGAVCNLAFALRLLALSRSLGWESESEWEGSTDAWAVDSVRVVWALLFAYFAAAAASCFIGFVGIAKHVRLFVRIYRDYSIADFVFVTLATLGVSYTTFSQPYVRSSVCEELSRHPELMRDMGEMGLSLENCEQWFERAVVAVLGIMFILIVVRLHIVIALSQYYSYISRELLAGVRTHILGMRTIKTDVQLQRIYLMPTPTSPSGSLLDGRSHQSPTSGDDVTVYATVPIGGMSEEDARKMHATPAWISTSPVSCSTSTPRSHRHSHSHSHTHPHARWNPHSHRHTSSRPVNDEKAPFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUC3</accession>
    <name>A0A2G8SUC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUC3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUC3"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1760.10">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007204">
        <property type="entry name" value="ARPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036753">
        <property type="entry name" value="ARPC3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12391">
        <property type="entry name" value="ARP2/3 COMPLEX 21 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04062">
        <property type="entry name" value="P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016315">
        <property type="entry name" value="ARP2/3_P21-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69060">
        <property type="entry name" value="Arp2/3 complex 21 kDa subunit ARPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL37332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="207" mass="23009" checksum="47A0A4CE716C48BA" modified="2018-01-31" version="1">MVRRRTGVCRPFAASAQAAAHSLSTYTMPAYHSSLNEVPDVRQVGNLSILPIKSKYRGPSPIADPSEADIIDETLDLFRANSLFRNFEIKGPADRLLIILILYVSDCLAKIGTSKTVPNQIEATKMLNTLSVDNFPIPGDANFALNAHYAPPGSRSDAEYLRGYLTQARQELASRLVEKLYADGTGKPSKWWMSFQKRRFMNRSLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUG7</accession>
    <name>A0A2G8SUG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">molybdopterin adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.75" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUG7"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051920">
        <property type="entry name" value="MPT_Adenylyltrnsfr/MoaC-Rel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43764:SF1">
        <property type="entry name" value="MOLYBDOPTERIN MOLYBDOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="6">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL37415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="323" mass="33996" checksum="DFCBA50AD3F63D6B" modified="2018-01-31" version="1">MSQVRVAILTVSDTASADASADRSGPVLQGLLTQAGYVCTRLQIVPDDEIRIRTVVLGWCDQGDVDWIITTGGTGFGAIKPLLEREAPGIVHLVLNASLQATPLAALSRPVAGTIKNTLVVTLPGSVKAVQENITALLQAGVVNHAIELVRGGSGQTVHEALASEGVRSPAPPPPPPPEAAVEVEVTPAPVPAEGPVRSPGSVRSSSHRHLHDHGHAHSHDHGHGHATPKPRSVLSQDPGLPAHARHRESPYPLVSVSDALLTIIREVQPLPAYEEPVTAALRGHVIAEDVYAPHNVPTTFSTNVDGYALRCMRLEPALRSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUW5</accession>
    <name>A0A2G8SUW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUW5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUW5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="522" mass="58010" checksum="E4B3E810578355A3" modified="2018-01-31" version="1">MPLINNIHLALDFRAPAGALYHALLPLAVQLLTILAILYIVIPLFRLFVLYSAPLSANNKAPHGHLSISHLPSFPSPFPWIGHLLGLQNDSARYVNRLLASAPQVFTISLPFKRVVVVNPSLERHLARHVHDTGLAQILAYVGPRVFNLGPRAIQVILDIDPRALHRVKFGATENVQALSERSSTFIWSEMEKLPLKSNLKLAHWMFGLTVSATASAVWGVENPWRMDPEFAQEFMNLSETFDSLSRPLPFITARSAYASRAFLSRRLQEFHFAHRSSRVQTVAHGINVIAHSDPQWETNPDYFNIEMVSALGLLATPSTLSVWLVRHLLASPAILRLVADEVQRLPVVPGETSGLPRLDLARVRELCPWLVAAWYETLRLHMTGVPRLARHAFDFALPDSDPVAVAQGDIFLLPMSAPNRDPELWGADAEAFNPGRFLTPAEELSAALIRKVHAFGVAGNLCPGRVFGTEVALAVVGGLLRTFEVRSVDGKKFWVPGVRRGFNVGFERYADDVEVELVRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUX9</accession>
    <name>A0A2G8SUX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUX9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="12329" checksum="8310F78559A13488" modified="2018-01-31" version="1">MHHVLLHNFRFAFSIGDTTYVILFVLPPSIRYLVNFLTLSLRHLSSGLYFSATHRVVCSRSFFHTMHSGSNSFRLPDPWLSRAPLALAHMFELQIRVVEHWTPCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV28</accession>
    <name>A0A2G8SV28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV28"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV28"/>
    <dbReference type="OrthoDB" id="21060at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID component TAF4 C-terminal" evidence="10">
        <location>
            <begin position="122"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="348"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL37626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="430" mass="46490" checksum="A0AF6CBE2B87BFBE" modified="2018-01-31" version="1">MKAEDSQPPPPATTTFSAAQWPQTTQIPIDPALQQQSQHPQHTATTPYSHYQYGHYAQSSYSHYPAYSQQAHPTQTATQPQTQTQTQTPQASQANVSTALRPVTQTAPQTQSGVDTTDVATLNDALGSAGVDLRAEEETLQRTNDQYYSYRPYEDRSRKQPDKPQFDTMYLGSKMRATSTTYKVPTIPKESIDYVALALRFRLQGLLTAMIAAARHRTDAQFDSPPSTYEDGQPMWSIKVRSDIAKQLEALQKAYREEDMKERRERKERQDAQAAQAAALTAASGGAGADGAPAEGEDAGPKKKKKKEGPGVTARNMSEDVRKKMSNAVASQAAGLGTGKYAWMSAASAGTTPAKPKPTPRAGTPATTTAPAPNANTGGWARPYQSSKTTAQQAQKDDDGRLAVTLRDAVFVVNNEKGHGGGRGSARGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV83</accession>
    <name>A0A2G8SV83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV83"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV83"/>
    <dbReference type="OrthoDB" id="2739885at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="235" mass="26194" checksum="B8108D9F51D65819" modified="2018-01-31" version="1">MHIYNGKFSCEFASNEAITVVFPAGFELHDPVSAYWQWTNDSKLGLKAGVANSGHIHSITKTSNGYYRIHFSFGHYSFDGTMAGDCQTLCLIMVYPSETGLVESDPFTLTAMHTNTSNVRSGIVYTGNLEWAPNAAEEMVTIVVPYGVTEGAFFGLYYQWTMSPLKHVPKQNVAVCGVFQDVKIESNGTITTTYKDAEYTYKFTFCSNKKGFFVVSHNRNGSRSDDNAFTFAYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVA3</accession>
    <name>A0A2G8SVA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_01393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVA3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SVA3"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="64"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL37699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="580" mass="63358" checksum="274D453208F53419" modified="2018-01-31" version="1">MPALPTSRRPPPQSSAGKEIMDDDGLEKSRPESPSDAKRPIWKRVLVGDANQGNETKRAMQSRHLTMIALGGTIGTGIFLSAGSAVALAGPGSALLSYFTVGLFCYGVVISLGEMAAYIPVTGSFAEFGTRFVSPALGFTLGWNYWLQWSLTIPSELTAAAVILQYWGPNIKPWQYALMIIFPIFIMQLIHVRVYGESEYWFAMIKIIMIIVFIFVGLIYDWGGVHGHPGPGLANFHGGQAFIGGFGNFAQTFVFAFYSYGGVELVTLAAGESASPHKSVPRAVRATFLRILIFYILTILTIGLCINNQDPTLLTAADDSSVAASPLTVVFVRAGFGAAVHVVNAVLLTAVLSATNSCFYASSRMLLALARHGQAPRVFGWVNARGVPIPSLVLSLAISFISFLTTIWGEGVVFTWLINLTGISALLVWGTIGAISLRFRAAWKAQGRAIEDLPYVQPLYPLLPLLTVGLAVAMLAAEGYAAVVEQPFDWRHIIATYIGVAVFVATYIGWTAYELLWLRKREHFVPLMDVDLDTDAVWQPGDGERVRAEDQAAREKRDAQDLANGRRWRVWARSILRHIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM17</accession>
    <name>A0A2G8RM17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM17"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM17"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013647902" description="Glycoside hydrolase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="51701" checksum="A5064508BDFAD750" modified="2018-01-31" version="1">MHFRSILTSAGLLAAAAFTNAAPTKVARDSGVPKIVVAHHIVGLTSAFTIDDWKSDIQLAQANGIDGFALNIGNDPFTSTQSDLAHQAAEQLNSGFKLFFSFDMSSFPCKTADDAATIRSLTNQFASRTAQLQVSGKAFVSTFAGESCTFGAADAPSGWKTQFTQHPETTGKVHFVPSFFVDPATFSTFSGVMDGDFNFNSGWPLAITAQNAAQTLPGVDLNNVNAVGETALQKFIGSFDTDTQHITNLANVQGSAQTYMAAVAPWFFTHFGADTFNKNFVFDGDEHLWVARWETLVANRDKVSLVEICTWNDFGESHYIGPQHGALPPGSEKWVNGFSHEGFLSLTNFFATQFKTGQAPAIAKDQLVMWARPHPKNATPADPVGAPKDFQLFQDKMWAVVLATADGTLTLSSTASDAQTFNIKAGVNKLSLPIQPNGFMHGVLTRNGATVIDLKPDNFTFNANPPAFNYNAFTAHATAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM78</accession>
    <name>A0A2G8RM78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15302</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM78"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM78"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="290" mass="32277" checksum="6B20C8AF64E0B56B" modified="2018-01-31" version="1">MARPTGGCPPAFDATAVSTALSSWAWWKGLWDTEAALAYLTWYAYVVVAWLLLPGEWIEGTVMRDGRRKKYKINAFPTALLALGIAVGIVYQKGPEPLTFVYTHWVGLLTASTIMSLVQAFVCYVASFREGALLALGGNTGSHIYDFFIGRELNPSIGSFDLKSFNEIRPGLIFWIVLNIGVPALLTTMDITTDGFGFMLACAITWVPFTYTVQARYLVFNQVELGPVYTALIIGVNLLGYYIFRTANGEKNDFRNGKNPKNLQYMTTESGRVTCLWLSRGRFQRGSIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMN3</accession>
    <name>A0A2G8RMN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_15466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMN3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMN3"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL22772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="295" mass="31326" checksum="F094E2E601351BE6" modified="2018-01-31" version="1">MSLPQPVPPSWKDLGKSSNDLLGKDFPLNGVALEVKTATPSNVSFKVGGNRDTKSTLIGGDIEAKFFNKPHGLVFTQTWTTSNVLKTQVEIDNQIAKGVKLDLQTSLTPDTGSKTALFTTTYKQPGLHTRAFLDIFKGPTFTADTVVGRDGFLVGAEASYNVTDAKITKYAAAIGYSAPEYAVTLHGLGNLTTFAASYYHRVNSDVEAGAKAVYDTRSSTAGAVALEVGTKVYLDSAAFLKAKINNSGILALGYTQNLRPGVRANFGLALDTQRLNDTTSSVAAHKVGASFTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNS8</accession>
    <name>A0A2G8RNS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNS8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNS8"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="273" mass="30389" checksum="D816AD319FADAEC0" modified="2018-01-31" version="1">MSALRALRQLTASSSRSFAARTAPRSVARAALAARVAPVASRAFSVSARRFGEGASDVALTQRLEEELKFETADYPNGQRAEPEFLKAFKAQGTWAIVDVPGLDEVTLTRKFGNEDIRLIFSIADIQSDQQPEFEEEGAEAAEEEDGADEEGVTLHSYPIRCSFSFTKASTPGALTIDAMCQEGSFVIDNISYYSDAKVGTELTAEADWKRRGFYLGPQFDTLDVSLQDEFDKFLQERGINQTLAYFVPEYSEYKEQKEYVSWLTNVKTFVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNZ7</accession>
    <name>A0A2G8RNZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNZ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNZ7"/>
    <dbReference type="OrthoDB" id="3226344at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="432" mass="46400" checksum="E1781A6A792A7A62" modified="2018-01-31" version="1">MFSSPLFRPIHARHPSAPVLARPSHTPGLLNITKPPQQVAPRPQPVQSQPRAPRASPKSKPQQRSPQPSHAQAAPVEKAKAPATFPAKVDQPSTTTDKPVRGRKQHKQPKDAGRRGTSVSPSDVAARRHAHQPSPPPARIPSPSKAPSAPRAQVARGKPEEPTCSTDPFSDDTRAPIEDTKREPKAFRSPPKLTSQPSGKLARRRQATTQLLDSPTPKVPSRRKARAQGETAALLQPAFTLRTQPPRRASVDMTLQQWDAFPICDDSSEFGDESDMTPPTTPIREASTAPSKTNGMWQQGKFIVDDAPHTAPLASTSGFPFAGNSPCSTPTPAQRRRNHRRVPSEGVFSMSADESSSSSVSDLFESLQLKRHSPVSIPRQRCSTVPAGTPSSFGASPSERLMSSSAPPAAGYFAGSVFQNSPSPDDLPAPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQR1</accession>
    <name>A0A2G8RQR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_13594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQR1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQR1"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="327"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="521"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL23843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1051" mass="117473" checksum="A595030B75A55FDC" modified="2018-01-31" version="1">MSTAGRKRKHATSSKDSPGPSKKLRTAKQGKKGANIAAEAIQWPEYFNSLFKVYKALNTVLAFCSSRKNFAITFPVVRTSVEAMLHEPLELAKVAELKYSPALLPEIVKFAYTPRIELRIHSDQQGGSSRRERSPDFSAFRTASASGSRVNDVDEDEHVLVLDFIDNARGKKPANPAFGYSLPPALTPAATKKLVERRNDRFVEAVNELVKATPQGEDPVVLLQSAARDHIPVHPRLKNPSIEASQSDGKGKNREVPEPELRPSIEEVIHDIQQQVWYREQIASQRIFEPRQGQFAHLYPPLSETISGALRDSRKITALYAHQVAAINSLTQHRHVIVSTSTASGKSVIYQVPLLQSLEADPDTTAIFVYPTKALAQDQRAALEQLLCSCPGLQHVKVSTYDGDTPQELRSAIRETSSVIFTNFDMLHASILPHEDQWRRFLKNLKLVAVDELHYYHSIFGSATICKPKQHMKNLSGIEEQEIEEVTEDGAPAGRKDFLVWNPPLKDPMDPSLGRVNSMTEATRLMRFLMARGVRVILFCKIRKSCELAMKTLRQELSADGRLDILERVMSYRGGYSQEDRRRIEREAFSGNVLGIIATNALELGVDIGVLDAVIMLGFPMGGLASFRQQAGRAGRRARDALGILVADALPVDQYYVEHPDELFDRSTNDLVIDLDNKVILEAHLQCAAHEMPLTAEDEKYFGTSMAEICETKLSKDKEGWYHTHSRYLPYPSKHVSIRGIEDEKYSVVDVSRFGRPSGTVHILEEIELSRALFEIYEGAVFMHQGLTFLVQEVSHDSKMAKVVRSDVNWITEPRDFTNVDALQTTRIREIKGSPHRAFYGRVELFTLVYGYFKVRNKAIIDAVDLDTPPWQRETTGLWFDVPKSVLGMMRHHGLNPAEAIHAACHAFLNRFALATDLRTECKVPEKEYKAVVSQRKRPARLIFFEPSGKHGGVAAKAFDHVNDILRDAHDKIEACSCDQGCNSCVVSPSCKEGNLVSSKAGALVIIKALLGQPIDMDLLERQSVQSQPVHDTVVEATIVRVAEGVEVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQR7</accession>
    <name>A0A2G8RQR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13605</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQR7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQR7"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL23854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="384" mass="43468" checksum="67B5DF443145030A" modified="2018-01-31" version="1">MAQRNGWLRGTIIRKSGASTGGSTRTGTPSQVQSTSATIYGGGVKDPSGRTSEYFSMDDQCPVCKSDRYLNPKLRLLVSACYHKMCESCIDRLFTLGPAPCPICNKILRKLAFTPQTFEDLTVEKEVAVRRRIAKEFNKRREDFADLRSYNDYLEWVEEITFNLINDIDVAETEARIQQYRVENAALIELNIKREEEYQRYLQEQEEAERQERELRAQELRRLEEEERDEREKAKQGIIDRLETSDKDAARLVAKSRAEAQKRASARAASSSSFSQSSARLLRSRAAQSTVVPDVPHIPLQDDYYGYGDMFVQRDTYYDPVSEAVRKDREGIMRAGGYMIDQAWERALRFAVAGLEIAPPTGVSRQEGMAVGGKGPADVVMATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQV1</accession>
    <name>A0A2G8RQV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQV1"/>
    <dbReference type="OrthoDB" id="3242721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="235" mass="25547" checksum="15F2567F37F3B5E3" modified="2018-01-31" version="1">MNFNSNDNLVLVAPRPVRLASGPAPFPFHAPIAHRPRSRAALLSAAADAFDRLKLVEDHPDQQPELSDKDALSPRPSPRSTPAEALEEFLSILHHPATIRFQPTSPILRASNHNTHFFTYRRQTPCSLSPSLPSEGLGLTLGDHADDKENDTISYPFKLLGTSLGSPVSRMQTRNPFQRHPPYETNVAGLLGPASALSPSPTLALSPAAIPLPLPTPDEMELEAAYHLKDDILTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRB2</accession>
    <name>A0A2G8RRB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_13800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRB2"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="219"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="293"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="420"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="486"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL24049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="500" mass="55573" checksum="1551E9819AB7B01A" modified="2018-01-31" version="1">MSSSMVSHWPPTLTDQQREELTLRATTYALSHGLIYLPVADVQPPAPTSAIHAPLALFPSPFPRKQFELAKRLQHAYNVLYARVALDEKFLDRIMGAEVGVGRVDDFTGELWKIWKRLCDEGIQQRLHLGLFRSDYLLHAPEKGGPVSLKQVEFNTISSSFGTLSQNIANLHRHLAASTEYFNSSPFLKLQNLPPNETIAGLAEGLATAHKAYESPSAWIMFVVQAGERNVFDQRWLEYELLEKHSIHIVRQTLDELATSAEVVPGSRILRVKLPGLLPRGAESVEISTVYFRAGYTPRDYPTHAHYQTRYVLESSVAIKCPSVQLQLAGGKKVQEVLTQRDVAFQFGEDIEVNLLRSSWMGMWGLDENGDYGVHKAREQAHKLVLKPQREGGGNNVYKEDIPGFLDALPVSEREAWIAMELIETPDLGNYLVRAGSGTEGAVKTEVVSELGIFGYALFGPGRPVEEKEVGWLLRTKGKESNEGGVAAGFSVLDSLVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRS6</accession>
    <name>A0A2G8RRS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13970</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRS6"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="409" mass="44595" checksum="C733C86A9C488B3B" modified="2018-01-31" version="1">MFSRNLGLMFTGVAIGPVLGGLLIRFTGTFIIVFYISAIIHIIYALLVWFVIPESLSKADMLGARARYKLAKEEYFAAHAHGGALVFFKRMFSFLTPLAIFLPVRVDGGKPSKGRKRDWNLLLVVMSYGFVISLLGLYLYVIQYLEATYEWNAEQVGYWFSSVGAARAAFLTLILPMVIQFFKPKAAPIRLPQDADEPLASPTDASFPAEQPSRVLSPPSHREHHHHHDPNFDLNVAKVSVGIEVLVYTLMVFSTSGLMFAGVATLGAFGMGFGPAIQSIALTLYNRRGGKDSGKLFGAMSVVQSLSSGVLGPSVFGLTYMNTVSTYPKAIFIMGCGAVTTSFLLLQLVRLPKDAPVARSVEDVDLEDRLIAEPGGFGVEREDTLVGPSEPLVIVDDGDRGHKVVKTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSH9</accession>
    <name>A0A2G8RSH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSH9"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="199"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1004" mass="113563" checksum="7392A46212C15BE6" modified="2018-01-31" version="1">MLERERFNRTRTGENWRDERKFRQRLSSLSDAHAVSAPYAHHIRLVFHTEADIRQFADLCVVADLKRPFWANVEAFNNGFFSPKQLHLYHNWLAQFPWAVAFQLEALLHNGLLHTEDLLKHFRGPIEKLCREHPKDVGDILRDFSEALRTKAPVDTHMDCFRRVVPGTGGQKWKPMRGDDEMTERARDAGKFQCYHVTFTPTRLLLEGPYVSQSNRVIRQFAGYEEHFLRVDFRDEDRLQYRWAREVDGTTLLEERVGGTLKNGFDLGGRHFEFLAYSQSALREHAVWFMNPFQHPTRGFVDGQIIRDSLGDFRKVISAPSKYAARLAQAFTATDPSVSISHDQCEEIPDMGTEPYLFTDGVGTISPQLGEMIWEALCTAKEDLILHERKPSAYQIRYLGYKGMVGIDERLEGIKMCLRPSMNKFKALDKAEAPIEIARWFDKPGTSYLNRSLVMILEDRGVDKDVFVKLQEIAVKDVITASDSIEGTVQLLKSHNIGLSFGLPFILNGLKAIGMGMEGEEGVATGTLNQTFLCSLFSYAQAHILRDMKHSARIPIPDSYLLVGVADEGPAYEEEGVENVFKLKVNQIFACIQKEDDEEPVYLQGVVIISRSPVVHPGDVQRVYAVGKPPDDMVCSFRNLKNVVVLPSVGERSLASMLGGGDLDGDVSPTSSSVTDLYSIIKYAPLLPTEHAEPAAYEPVGTRELPNGQESTVDDICDFIVEYINSDVLGLLSDRHLIIADQSREGTNDPSCIYLAELCSQAVDYPKNGIPVDIHDSPRFLIRAKPDWKMAEDNDPRDTDYYLSSRALGELFRSIAIPKPKAPSESFPNPNGPQIVSTQPKRVQPLADVISLALKPLIEQQLHYSENADRNVADMRTLFLRYEQELRYICVTHALSDAPDIRLQEEEVTIGTILANCSQHRWRTDRMHRMRMHAGELTREIRYRLYRPSDFLNPDQGELLYGLSQAWLAWDLGMRNSSVFGARSFSLIALGVVLDTLSKLGGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTP9</accession>
    <name>A0A2G8RTP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTP9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTP9"/>
    <dbReference type="OrthoDB" id="2758175at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="484" mass="52687" checksum="9B20F7CD1491EF69" modified="2018-01-31" version="1">MLSASRVAQPAIMPTPVSLPDLNPILSPGVPNQWTADPPAADRTASFPERDQAGNALILERRECDYPHAAKFWTKRKFDISQKEEATIPGAVKGRQGPGRLKLNNENVSMQFVIDAHGHSIDGDRAQAIRAEMRSWFRGCKDLPKSWKNGSSVEMRRALYLHMYKTFPELQLANYDWKVEQIAIDVFAQLAAANRKAAKKEKSSKAARGRKSRKRARELSSEPESVGPVDLNDAGYLMLPEYDQQETTGSTTIGSSHSTSVETPHKRHHSGPGPATVNNPSLTSPVVSLSSPLPVDDVPLRSPIPFSAPSVHLDALDNTPSSVLSATNPLSQAGACTEENANESSPPEVQPEEPTPASIDVNIPKEVYTISNPLWTALEGVASSGPLPSPSPPPNPGPSKPAKTLKKTMAHVWPPTPSNTKPKPVCARIWCKHNPDGTEEMFEVFYKQMSQYHRKKYIACDGNVPATAGGRKAKTEAENKENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTT4</accession>
    <name>A0A2G8RTT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTT4"/>
    <dbReference type="OrthoDB" id="2750727at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013943380" description="Transporter" evidence="2">
        <location>
            <begin position="23"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="31862" checksum="46E1F9DD35F03BB5" modified="2018-01-31" version="1">MLQWATLLFNVIGYYDVAQAYAAQLQCQCTTDEAVPIIAISPGTPSCSLSGFGLPGAIHGLTVCAPTIILTFNVVLGDAIVWWRVWAIWPRSLVVRGSCIILLAATLGSGIIDSMDSCPKAAFSVLVVSNLTDIPTGSFYQSDLFGLAASVLSLANNMVATILIGCKAWEHREIMIKASLDRKGQVQKVLIFLVESGAIYCLIWVSILVQQVAILMDTGEVSPSEPKALTQFDYFVKGCLIPLIGMYPTTIITLVALNKSHFHEAPSNSGTLSNLSFRYPTSEASTHGEGRDGWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU73</accession>
    <name>A0A2G8RU73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12949</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU73"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU73"/>
    <dbReference type="OrthoDB" id="2749397at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="77" mass="9154" checksum="97EAD99736A106B3" modified="2018-01-31" version="1">MNKSTEIAIAAKQGKVEKSLEELLPDYALEYKRVFEKKAVERFPPSTPWDHTIDFKKDFDPHKHRTWHKIYPLTVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUR3</accession>
    <name>A0A2G8RUR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_13144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUR3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUR3"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="3"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL25255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="451" mass="47833" checksum="9FF3B743D7DE2AC8" modified="2018-01-31" version="1">MSDATSIAKAAKAAFEASQLIASSERVQALSEIRKELEAAKDAILAANRLDLEAAQKEVDAGRMSGSLLKRLDLNKGDKWDSMLQGITDVAELSDPNGIVSYASELDDELELYRVSCPIGVLLVIFEARPEVVVNIASLAIKSGNAAILKGGKESNETTQLLSKAIQSALSKTSVPSTYIQAIQTRAEVSALLELDQYIDLVIPRGSNSLVRNIQNSTRIPVMGHADGLCSVYIDASADPKKATRVAVDSKIDYPAACNSAETLILHESVLPTIWPDVAKALLAADVTLLCDPPSLAALQDRVPASPQVLPAPPDAYTTEHLSLTLSVLTVPSLVAAMAHINAHSSHHTDCIVTEDAQAASVFCRGVDSAGTFVNASTRFADGFRYGFGTEVGISTGRIHARGPVGLEGLVTYKYMLRSTGGEGHVAGEFGAGEGKKRFKHKRIEASAVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVQ5</accession>
    <name>A0A2G8RVQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVQ5"/>
    <dbReference type="OrthoDB" id="10395534at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="375" mass="41566" checksum="37129BDD32C7AE97" modified="2018-01-31" version="1">MSGISTTFNERGWEATVHDIEVMITFSALPTALQLLLTVLFVPSFIMLFSRWRKIGPSSFGLAFNVFVLYISSWVYLVTNILSVKATILQAILESPGALYGIGDLNSERNQIEDSLMRYYSISQCAGTATLTLNVLFANTIICWRSALLWRRSIIIVWLICGFMLSATFAAGAADTRWACWPWAISGPGTDTAGSGNMYAGYAAGVAAAVLTFATNLLATTLYVIKILQSTEALEKYMAQGSKFSNVLTLIFESGAPYCALWIVVVAWAAGMNTQAIAWNYYENSFWDIFDVLVNAALVPLAAIQATYVVWLLVRGKSAVEYCVAEAAPPMPTFLAFQQQPVETMMHAQFIMQQQQQQQQQQQQQQQPVVQYAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWL9</accession>
    <name>A0A2G8RWL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWL9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWL9"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 3 N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="562" mass="59215" checksum="34A88D256D79E7E7" modified="2018-01-31" version="1">MATLTEAQKREIGQHFVFGFHGHEASDDIKTLIKDYYLGNVILFKRNVRSTAQVHRITTELQSLAKEAGHARPLLIGIDQENGLVSAFTLPDAGTQFPGAMALAASGSPELATEVSTATAKELKAVGINWVYSPVADINSDPRNPVIGVRSYSDDPETASRYVTAVSSAFTAQNVAPSAKHFPGHGNTHVDSHLSLPRILVDKASLSSTELIPFNALIRDNIGSIMTGHMALPNITGDDTPCSLSRAITTDLLRGELGYNGVVVTDCLEMEAVAETYGSEGGAVRSLQAGADIVMICHTYSRHVGAIEATYAAVTKGELSFGHLAASGERIAALKEKVAGTWDAVLAPFQNEQVATLKKEHQLLSRRAYAASISHIPNSKPFAPLSTAGPAVLLTPRMESLNRAVDDAESQLRDAAGRIRNTAGPAYSAFAKSIAARVPAVEHVVYAPDHEVPPELAEKLGAAGSIVFATRNGFDKGAWQIAVLEKVLRSASSAGRGVNGRFIAVSTCGPYDLLALKGVVVPAIATFEYTVPALEAAAAAIYGESAITGNVPVKMMASGNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWV0</accession>
    <name>A0A2G8RWV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWV0"/>
    <dbReference type="OrthoDB" id="3214103at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013762229" description="Transporter" evidence="2">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19670" checksum="83069F640D707E93" modified="2018-01-31" version="1">MQSVFLLVTFILGVIDTVKGCHPSESSEGDDTPFVFPGTLFEGLQIGVAACVLSLSTNLLATALVAYKAWESRRRLRGYLIAKAGGSQVEKFLALLVESGAIYSAIWAVVVAYQFAQYKYTNTFTSISTTETGFIDTFGAIMSGALVPVIVRAICADRKAFKFSLHLIGFRPFTLPSSSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX02</accession>
    <name>A0A2G8RX02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX02"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="90" mass="10088" checksum="8C9F9117E4627038" modified="2018-01-31" version="1">MPVQCKHFDPFGNKVHNNGHRAAPTSFPSPIHITITILVAVKRGIWINDFKYTISLTQLFARVPDGVLQGFTMHLQSPEVVFQAALFQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX23</accession>
    <name>A0A2G8RX23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX23"/>
    <dbReference type="OrthoDB" id="2801180at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="46810" checksum="A34A40EFC4745626" modified="2018-01-31" version="1">MAQNDQKTFLPNLRTLTWVETPDYDGILALLASPSLTWLELRVQSNTRSRQVEKAIHTLSLNAPFLSSLPIHSDNEDLEPLMSGFQRLRSLVIHNDVTRPDLKALTPRCRQTLQDLRYCPESFTVALDDTMGRLALPNLRSLQLFGPLTDRMCAFVAYLHTPDVGSLKLELRDEKGNSCNSASLPAHIALSRTVSEASFAPALRQLSITVQTKANLSTDPTTVGGTRVMGAMLLLFSLVGLRVLVVVYFCSDATLGTDADMLAAATAWRDIEHLSFDFPFSDVYDQGGFPCLSSLAHFAAHCPRLTRLRIPLAVLDPPPELEGNLGQHSEGTGEWPPASLHPLRTLEIQVRQWGSEMEPEMVARRIDELFPNLGRDELRFRYPIRPRIAPRRYQGRWDSMISAWKELRAAREGDVRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX98</accession>
    <name>A0A2G8RX98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_11895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RX98"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="410"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1330"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="511"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="889"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1645"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="518"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="910"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1645"/>
            <end position="1656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL26140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1681" mass="189140" checksum="04774BC45B7DA8B4" modified="2018-01-31" version="1">MFVQESDHLVALRALPVNGEHRYVRLQRLLQLLRNATGFDPKTNTETRKKKKGKNTTKSKKRSHDEDESSDDSNPRKRTKVSSGDAINVTADERLFPVFQRVLRLRYSTSPDVPNLYPPDYVDDERAAGFGWINVEQTLRDWMSNYAASKGDTDAIQLGSVSVDSLAHGVYEAEHDSVWPLLYLPHIRDSFDPKDYDLFSGQRIRNLHNLLQAFRLLEDDGRARITSTLSVVLSPDHAPNEMPFFLQIQVDCSFICPKIFDPVTPAGKAMSENTRVLEVQEAQRLVILQLFPPSIPLPDSYHGTADIPFLFSILGPAPAVPSPAALDALQPEALLPTLLPFQRRSVGWMIGREGKTITASGDLVSSAEINVDEQPLPLFWHRHLVSTDETWYVNRLRGIISPIRPTEEDDDLAEDASGGIVAEEPGLGKTLECISTIMLNPAPDRSPVNTRWDPEAKLDVKEIKTTLIVTPPSLAPQWADELAQHAPGLKVLIYEGWRKVPVPISDRDVAIEREKRKAAPKPAKRKKAGRSSKANGRSRGKGKARAKDSDDAMDVDEEPEESALEDGEEEILDWCAYVNKFDVCITTYNVLQQDLGVARAPPVRPRRAFVEYSSVNRSRSPLVMCEWYRVIMDEVQMVGGGRTEEMVSLIPRLSSFAVSGTPARSQISDLIHVLKFLRVRAVTDVPRMWPRLQLPGYVHEFTELFRRYTVRTMKKAIQDELTIPPQTRYLVPIELGGVERHFYDQALDAALLDLGLDVRGVAATENWEVDVAKLRHWLRRLRGLCTHPQVGALAVNAVDKLRKPGVLKSMSEVLETMREQNWRNSVEDRKDKISGMATLAQLTQLDEDNRNRYRQALDLLVDAEQEADKLIADLKEALVEHAKEREKLKAELRASRRQGSAETQGSASKSAEDENDKGKGKERAAGETPIDLDEDEEGLPRNAVGEAHKAKSTYLHGRIREARMALHKIKFLQGDVYHVLGKSYEASENEAYASAEDLRRLLLRGTEEAAERAMTYLDRDPTVKVLKEKDLYVKLPYLGKGGIKSWELMEEGNELIEGLLNEQSTLLWRWRQKLITLLTQPLGNSGEDADGQEYARSLDTQGEAEAYLQAYAALLADRRETLTAERTLLAVHDVREVKMRKTKAAFKAQSSQYASIKEMEVLELDQLDDQEVLPEHLVIAKTLHDERKALLDDFDPGRAVKSILVDLNNVAVNIPKREDPEKLLAQEGVAKLRSLIAEQGKLIDRLQADLGHLRKAFNERIAYFRQLQEISDTVAEAQIETTLLDTMGELRRQQAQLDTKINAARARQRYMDNLSKSHEEGTMDEDDKTCILCKCDFMRGYITQCAHVYCEDCMKAWIVRPAGKACPVCRVPIHPDQLQRFSLDNPSEPAQAQAPAKLLDSNEALPQSRREILYNFVSGQTMQDVQSMEMYGSYGSKIETLVQHLLYIETTDAGAKSIVFSAWADSLLIIEHALRANGVTCLRIDQNTRKTNAAKKFRTDPTISVLLLHGERENAGLNVTCASRVFLVESVVHHAFEVQAIARIDRMGQTRPTEVFCYYAEDSVERNILDLAAKQGLSLYTRDNAAGTLNVTPFATDSDKKQVDAPSKKVQKGDFVYKTDDMLAIFFPHMYEDIEYLLPPEDLAQQNGFGSRSSVVQEDGPRRSGRRAVQVNAEAGPSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXB6</accession>
    <name>A0A2G8RXB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXB6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXB6"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="38522" checksum="03D9FB967EA2446B" modified="2018-01-31" version="1">MKQSRPASASSFHDKESLKKDEEFWFEDGNLILVAGDVQFRVYQGPLIAHSLVFKDMLSLPQPAEDLVHRERHGDHSCPTVPLTDSPEDLKHFLRVFTTGMTPTTMRSGPHDPSFNEVSACIRLGHKYQVDHLVQRNMDFLRKYYTDDFDTWFPSNFVRPPTFRSVHAIAVVNLARLTNQPAMLPTALMDCCTLGAEIVNGIVREDGTRETLTQDDLGRCFVGRTKMAQASARIAHQMFRQTVAPTCKHPGCCQRVLQRLLNALGDARDEVISCVDWYASWMVYVDGRDEERELCIRCYKMLEGDRPKRLQREVWMNLPEMMGVTVEGWGTKPKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY46</accession>
    <name>A0A2G8RY46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY46"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY46"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF219">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="158"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL26414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36146" checksum="5547354DBB9A42ED" modified="2018-01-31" version="1">MLPFSLCRAPSSYVGHELLACVRPVFGIVHRALQKVGIEPYSDLNSPKKPALERQARLKICTDTLVTRVELVTEGEDMHATGVEFENTNSRKAWKCYFAKARREVVLCGGALGSPQVLMLRLGPKEHLESKATPVICDLPAVGSYLQDHTLLSANIPPKSIGSVQLASSNPRVRPDVDLGYFNDPEDYVPLRKSIRLAQRIAVEVREQRYLLKDFIVPESSDDEVLSAYIRASLGTCFHYVSAPMWHGDAMGAEAYGVRRRMGRGGVWGAEAYGARPSVVDTQLRVHKMRGLRVCDASVFPKNVGAHMMEPTIMVAEQCGDILRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY96</accession>
    <name>A0A2G8RY96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY96"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY96"/>
    <dbReference type="OrthoDB" id="2797394at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="297" mass="33044" checksum="3532C81AA66CFD2F" modified="2018-01-31" version="1">MFASSTPIPSETFDGCPLVHLSDSPHDLAHLLRVLLPKSHIQYHVPKADPVQRTFDEVSAVIRLAHKYGIQPVQDQALACIQEHCYPSDFAVFSAPSSDSEPYPFTSIRRVHAIGAVNLARLTDTPSILPLALYRCASLNSNALLNGWTRADGTIERLSDTDLRRCLDGRVALAHERFFFVSRLFDDTPSKDCRSSKRCGRHLRDVHHSTMRSPGLIQVEGRSGGVLADWEPVVRSFKDGHNSLCGSCVEMLVERALSGRKRLWNKLPRIFGIDVEGWGEPDAESGSEDSDNDDEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYD0</accession>
    <name>A0A2G8RYD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYD0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYD0"/>
    <dbReference type="OrthoDB" id="2797511at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1262" mass="141623" checksum="175F2BA715C1DD3C" modified="2018-01-31" version="1">MSAFDPKHIVAVAKRLHSNDREEQDKFEKQWLENVEARWKGWQKHRDGSEQIAYVPQLEFIAHVVEYVNWVYGMTKTKHGRKPLSREIPLYGPTFIPPSYMHEQLRNGLKTTVTPETAYLKAVTIIHPLYFPQLEKCPRCGTKKSSDLDWYGWVPTGHCEVHGVDREETALGYQLRCKSCKTKAKSQQVTRKNGEGSYCFSTTNHMFWSRYEHWQIPAGIPIFLKRRALTRTLFDLIIELRVGSTSAGLEENFKQLHLLRYYSDKKAYLDRYQELVDHDRRSVLRSFKTPLQNFSAPTNTGGYGNSSISNDLISDVYLLFSENTRREESNEHVRSLSAITLSLDQTYRAAGKAKVVDGSKKQEKRWRGGLLDAVNQNGETVAWRFCQTNSASETSEMCEGLKKRTKMLKQPAPEVVVADNCCKVANAITTHFPDAHIALDVWHVLRRYMGCVLGGRGNGSRSEIANDITGAVLKTRADKYNPAVYWSSAEQEVRLEGVYNKWAKEGAWTTTGASTHAEQMKHVRKGCLTRPRNDVRADGSRIEGNHRAWNGLQRSWPSGLEMLTALCHDLVLRQNMRIGYHLSSPDVFTTSTYGSHHVRLIRAIAQQWNSTIHMAEYAHLFAGLSDLPLLKTVASGETFGIVKSQFAQGYQYLVTDVKHDDDDDDLLELTKPLDERTYQVLASIDIGPKPGPLPQLSTVPVPDLQPSPPSLPQPLAASLPPSPFIPLSPGPGPCMDVDVNTCIMETPALTPGAEESIQQDRRAQKRRAEPEDQYEHEQRQKKRSKQASSGTREHRRHLRSPDALLLPLNARRLDLRLQYQVPRGAILPADPCITAGTDASTSLSLIPSQAPSSIAAPPTTLNFSAFYQTLKLPPVYITGKTRSQRIFSIKTGVDPLSTKIEADDEHDLFMTLREKCQWVSHDMNPRKYVEAASVYNIELEKQNRLNAYVSYTVRKTPRAIMDKLANVEDQVIKRLISNDFTSKSSETTAYWKRHCFAVRLLVDKTNEQIKQKPNTCNRCKSIMWPGGKGKNNNHKLTFCSDGVRMSPEVTEKGLDGTTTTRFEALPPWPQPSGIFVKGSTFMPHAFLLTARQFYLSMITLGSGGGHNAMEYLAFAEMLHARTIAVPADDSESTTSHPAPAHPTPTHTAVDSNPASSSTAHTAVDSNPASSPTAPPSAIAIQALLDTCTIAKTRFGGSRSETDNVNVKMLFRLFDTFELGPCRKGLIEVREGVKYLRITPFQDNDRPVEEEEEEEEEAEGGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYQ6</accession>
    <name>A0A2G8RYQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYQ6"/>
    <dbReference type="OrthoDB" id="2140240at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="110" mass="11414" checksum="B72209C6A1C0B703" modified="2018-01-31" version="1">MLNYNPCVCSNCDGIPGSTGKPILGLIPCACPPPRDQFISALNANVAAGHMVNNTPILAPFPTGDSKAEQQARIATLLSTLQNLRGPGVGCPAVSTVYGQKQQEINALPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYU4</accession>
    <name>A0A2G8RYU4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_11282</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYU4"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="714"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="207"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="565"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="762"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="854"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="957"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="568"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="622"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="784"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="798"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="818"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="854"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="960"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL26657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1026" mass="108039" checksum="9DBAA12A7E131616" modified="2018-01-31" version="1">MRESNFAFPAQNRACVCISSQLYDRRALDTNSSLPLFNSLTHLVYLTSTSPRIREIMTMDGGLERLVRILHDFCISPPPQENPAIFYGLAPPGSHPTKPVPTLLPKSYDKHAAYRFSLAFQCIVNIGVRGSEPIRSRVVQAGTLEVVGCILEAWLASKGFPVGPSVAANGMPRETREQRAARRQAAMAQRQRDQAVAIARALERQIAEQPTIRSSPVDVSLASGPDTSREEPMQTDQATPGASRAQDTDTSAETSTNATPNGSNTPTGSVVVPGRDRSGTILARPVWDQPAATTRRVHRSRLNVPNASAGPSTSTSAANSRPETETEDDGDVDMDTSRDGDAPSPSPERQRSENGTIRATHSRRAVGIVSDTGAPAAPGTTGIDLPSDAHIIINDDGVVPGVGVEDGIVSLETNDDFAMGAPPGAPGALDGPPARAADGLTGAGERTPRAGTANLPMAAARQVPGTFLTPAAAEDERGRPMETAGRQNTVRPTNTLNATTTTTGGNGHHHHHHHREVESGPYRDEDVLLSLQLLAYLSKYPHCRQAFYKPRTSFHPATAQLSSDGRFGSAAGPGSSASSSSSRATAGSLTSASSTTPAKDVNPFVKAFNSATGRGKEKERASAAAAASGAASSSSAGPSRSGATAATGNNAPTPRMTNVFALVERFTYRHSSSELESPNPPPSLPPEIQYWAGVIMRNACRKDDSRGGIRQCANMLCGRWESFPREFAKCRRCRKAKYCGKECQSTAWSEGHRFWCSAKDPEEDGDHHHHGHSHGHGEHSRTGASGGAGNGGAGGRSGSASTTAATTGDGAAGQAQGRAERREARERERQARAIAAEMRLAQERQQTIRVSATSTAATVTATQTQAQATGDAGTSTSTATATATQTTGAGASRTPLPVLAAALADGTWTYRGANAGPPQWLTDAANGQGGERSQRVATLLRQEPDVARRHLARELMTSRAADRLEREREGSGSGRDNRERTATFPGHPPGSTSVAMDVEMSGVSPIGRAVSQPVGPENEDVDMALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYX6</accession>
    <name>A0A2G8RYX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_11200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000039">
        <property type="protein sequence ID" value="PIL26721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYX6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYX6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL26721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="546" mass="61730" checksum="B4193805E5EF3058" modified="2018-01-31" version="1">MFSVLLQAVLICTSTWFLWKFFRQSVVRSNLDNIPGPPSPSFWYGHVQKLRDKQGWAFHQEMADKYPAVARLAGPMGRKMLFVHDPKAMHHIAVKEQDIFEEATWFTRLSLRTFGPGLTATLGEHHRKQRKLLNPVFSINHMRHMMPTFYKVTYKLREAIEQRVRHGGGPTEVNMVMWMGRTALELVGQAGLGYSFGKLTEETPDELGDALKSLMPAMATLGAFLQFLPLAEALVPERWLAPLGWTVPVLGLRELMRISRTLDEKSREIYTKKKAALLQGDEVLAMQVGEGKDIMSVLLRANMAAAEADRLDEMELLSQMSVLTFAAMDTTSNALSLTLWRLAKHQDVQDRVRKEIREAREAAGGSDIAYDDLVSLPYLDAICRETLRVHVPAPMRFREARKDVVLPLSEPIRGLDGTLMHEIFVPKDTHVFVSISSSNKNPDIWGPDAAEWKPERWLSPLPETVSDAKMPGVYSNLMTFWAGGRACIGFKFSQLEMKVVLAVLLTKFKFDLTEKPIYWNLAPVTYPTVVADGSHPELPLKVTMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ60</accession>
    <name>A0A2G8RZ60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ60"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ60"/>
    <dbReference type="OrthoDB" id="2753986at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="21303" checksum="3AA6011AEF959B6F" modified="2018-01-31" version="1">MGVNRKLKNQRCCGRVCPCAFTGLVLTTSTPPSILALNDDVLRQVAEHLLGKDALSFSLTSKHVYDLAIHGVSALIECKDRDKLRLWAMHRTLFYDNPERAKHIQKLIVRGSVFPPEELYGSDDEQWDEREVLESPVAPLIVDLLRIACNIRCLTIESFDTLCASDPGVVAAMTALRRLSKLELFNVQPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ68</accession>
    <name>A0A2G8RZ68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ68"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013728647" description="Transporter" evidence="1">
        <location>
            <begin position="24"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36832" checksum="95E06692A761F4EC" modified="2018-01-31" version="1">MGESSSPSLALFCSLTLWVDILSSTMRCPKTGWTANRGFAGGRSRIWPKVSHSESTHTVWRVENAHIAMQLEPTRSELVVDMTRSLREYRRGHRWSNRHKSATLSYGSAPATFLDYASSTAALTDCTKDGASPCRSWPRSSLTIKPDAASIPNVISHRSPSDSKDACRYMCLDKPSAGRRMITHYELAQDKSMVGDGEQDWHPSGSRTERTPIGRHAMRYGIVVQPSFATSCSRSHLNTKDFSLSMLRAPHGLRTASASSSLKIKSCRQTFPSVGHPDAPLSLDAMYQASSMSTLLTLTEAGRTPRDPSKYTPRWRTHRNVISDHRYPVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZR9</accession>
    <name>A0A2G8RZR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZR9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="14099" checksum="F758564063ACF975" modified="2018-01-31" version="1">MVARPMLEGQSAREAVGGNMRCERKRNKWSMASASSRWRRRGRWTTLVRSGAGNIPSTVSSSFSDRQQIKDSVSRFGNNSRALWMAYSAGAWLMLEEERTAQWSNLRRDRDMYRAAGGWKCEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZX5</accession>
    <name>A0A2G8RZX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZX5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZX5"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL26858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="338" mass="35850" checksum="5B46F22883BAA346" modified="2018-01-31" version="1">MFGRAASIRPLVSQLKLGARPTRARPSFKFSTSPPRRAAGSNLTAPPPAYGPIGVARALQPGTTASPTIFTDEFSLADRVALVTGAERGIGLEMALALVEAGARAVYCVDLPKAPGEEWAKVREYVGALKGKTGVGEARLEYVCADVTDQEAMWKVGKTIGDREGRMDVGIAAAGILKPDSPCLTYPAKLFQQVQDVNVNGVLFTAQAAGQQMERFGNGGSIIMIASISGHGSNKGHEWVSYNTSKSAVLQMARSMACELGPQRIRVNTISPAYINTKMTGAFLAKNPEVGERWAALHPLGYIGRPDELRGAAVWLASDASSFCTGTDFSVNGGYLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZY7</accession>
    <name>A0A2G8RZY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZY7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZY7"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="288" mass="30277" checksum="1A163AC23968252C" modified="2018-01-31" version="1">MLSASKAASMRTVVALRVARARPSATSSLSFSTSRAVRTVTANVPPDGPLGVARALQASPTAPPEPTLFAREFSLADRVALVSGGHRGIGLEMALAFAEAGARAVYCVDLPKTPDKNWVKVREYARALAAAGKSKTGAGGEARLEYVCADVRDQVFDVNVNGTLFTAQAAGQQMERFGRGGSIILIASISGHGANKGYPWMSYNTSKSAVLQMARSMACELGAKGIRVNSISPGSIGTTMTTNLMVTPDIEKLWVEQNPLGRIARPDELRGIAVWLASDASSFCTGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0S5</accession>
    <name>A0A2G8S0S5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide synthase-like phosphopantetheine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10299</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0S5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0S5"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="565"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117873" checksum="7316171589C011E7" modified="2018-01-31" version="1">MAFKSPRTLVEMGETTLPDLYAWHAKHNPHYPLFRFHDGHDVRDITYADAFRAVNWCAGYVRTKVTTTGKATIGILANTDTITYCCTSAGIIQAGHLAFHISTRNGSAAVMDLLRRTDCKHILISQDEHITGVVREAFQHMQGIEVHPLKTFDELFSTGEEEDGSGMDCGRDIVAPDMLDSAILLHSSGSTNHPKPVYWTHKRVLGYGTVPWYGEVDLAGLTIGAHGVPMFHAMGLCIICTALCTGAILAVFKPTSPPTFPTPENIFEATTLVWNDYLLTVPAFIEQWSRDPEKVSKMQRIKGLMFGGAPLAQEVGNTLAAHGISLITLYGCTEVGTMSNFVPAKPGMDWAYFKISDWNHSVQVHAGENKHEIVILSNPECPLNVVNTKVDGRDAYATNDLVEAHPTKPDLWRIYGRKDEQIILSNGEKTNPVPIAENIISENPYVSACIVFGHGKFQNGVLVQPPPEYQFDPEDKQLLRAFRNTIWPTVERANEFAPQHSRIFKEMILVTSPSKPLELNAKGYPRRAPNLKRYLGEIESIYTEVERSAQSDVLSPTTWDSKEVRQFVKTAVEKVMQRPVLDDADLFRSGCDSLQATWIRNTILRVVREHFPDAAKRLPTNLIFQAPSITALADAVLRAVHGTNDRSTTTVTEEDLVHLAEKYSSNLPLRPSDLRPRNLGKNVVAITGTTGGFGCDILHHSLLDGEIGMVYAFNRRGSNAMDRQRARFRERGLDESLLDLAKFKMVEAELEVPGLGVDPALLDEVRRSQETWRVDFNLALPSFEVDLKGVRNFVELALSSPYDTPPTINFVSSVGIFGRCTFQPPVPEIAIPPAHALDTGYSESKWVAEKILSNVAERAGVPSVVVRLGQVCGDRLGHWNEKEWFPALIKSALFTRCLPDPSGVVSFIPSYPAARAFVEMRNAPGAGDGPLSPSYLHLVHPRPVPFRTLVAPIAAALTVPLVPYAAWLRALEASLADAEHEVDAMRANPALRLLDFFRAQTAEAEAEGRVPEGKEPMGVVRLVTDVGERTSAELARLPSLDAETSLAWVAAWRRSGFLPDPAVGAPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0T9</accession>
    <name>A0A2G8S0T9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0T9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="192" mass="20982" checksum="05DA290ADDBD4EAF" modified="2018-01-31" version="1">MKVNVDYQGFAVFVIYETSQSLSFPSNPNPVMPCVPDDLNLWPAFLCACIGDTSEGNPIAGLTLLRWYAERPVALHGSNSSLFRAMYRGGLLFHSIVNVMSIGNIMAMFFAPPGLGSFLRMPLRVVRSTLSTRLLLNLRRTAAVTWRGDIGISDSTPTNLVVGMPSLPVEHGECPSDTALALEDDGSFDELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0W1</accession>
    <name>A0A2G8S0W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0W1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0W1"/>
    <dbReference type="OrthoDB" id="3242376at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="330" mass="36518" checksum="BA78DE8FD5180859" modified="2018-01-31" version="1">MRDGIMYFAVIFVSNLVTVLIFVFAPPDLKVINASFSTLITSLMVSRLMLNLRGEVLRRGPVISSHHSTSHNVRDNVVESYQLGYTKQETETGWSAFSSIVGNLGAPVITFEAENSSYYDDFNEDEDDVIDPGFLQTIPHNSKSTRKPLPHIPHVYPPPPHSPRSADRMRKTYDSHSFHSRQLTESSDETMGWTKVSMPDTPPPSGPSSPTLRSVNRQPSAESSSSASAFNFAALPHKTKLARLKSLSRPRTADSATSERDVVEMMQTRSMPAPLVVQVTEEVVVDHVPDEDDGGQDPKSAEGGSGSRNRKPWLAPPSWRLSRDGHYEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1B3</accession>
    <name>A0A2G8S1B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1B3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1B3"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="341" mass="36741" checksum="A5D23AD9D41C9931" modified="2018-01-31" version="1">MPSLVDFPSTYTAYAFLEPGGKLQKIDVPWKFPESGEIVVKVLACGVCGTDETCTSQVMPVPLPRVPGHEIVGDVVAVSSDEKLWKVGQRVGAGWHGGHCWSCNRCRAGDYMTCENQSVNGVNRDGGYAEYVTLRSEAVVKVPEDMDPAEAAPLLCAGISTFNPLRHMPVTSPDYVAIQGIGGLGHLAIQFASAMGFRTIALSSDGSKEQLARSLGADDFIDGSRIDQVQALQKFGGMKIIMATAPNARITENLIHALAVNGTLLVLAVEPQPMKIPPLALLVKRLSVRGWPAGSPKDMEDCLAFARAKNIKCLVEKFPLHKAEEAFDHCKTARFRAVIVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S208</accession>
    <name>A0A2G8S208_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S208"/>
    <dbReference type="OrthoDB" id="2921803at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44388" checksum="58F594A7558A7147" modified="2018-01-31" version="1">MKFKFSSDGIPGELIDAVLYHLNDDRVSLLACTLVSSSWCSFARCHLLHTVVCRPNVPHLLPRHLSTFLPSIPDVIPHIHSLKIIGSHTAESRSEVAVEDVMSLLSALPKLKSLSLERVPLFTRAPLHGPPIEATPLPGSEPLTINLCAISYTDSTDSFFRVLRDYLGLKPIRAFLRFAIHDDHSSFPAFLDIFGRKIIHLSCNLLGYLGDFSFLIADPESEDQLYEQNLDSHADAPPCTSVADLDLYLTGSGVADPDTQLIVLGGQILAIGELAKFLAPDAPIRRVTLRFQRFGPHTRATERMLSQILVPSNWFQFISSLERLLLQFRRLETLTCVLCDDGLAEQYGDYVPAVPMPTTVSSVAEVISREEEYAFYESFVRRAFPEFLAKGVLQIRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2M0</accession>
    <name>A0A2G8S2M0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000030">
        <property type="protein sequence ID" value="PIL28020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2M0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="147" mass="16215" checksum="E60DB143BF43FE77" modified="2018-01-31" version="1">MSKNFWASVDHIAVSPDGRAVLSGCSDGSVVVRQMHNIISMEDQDNGFFQLKANHVTSVVDPMIPSSLFDHRARTAPARPPEIRHLQEQDLVSREFRDLRLGEFLEGDFAPLDQENEIMDANTPMIDGESTKSGFMATATAVGISKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S383</accession>
    <name>A0A2G8S383_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000026">
        <property type="protein sequence ID" value="PIL28230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S383"/>
    <dbReference type="STRING" id="1077348.A0A2G8S383"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="24276" checksum="E2689980D60F8C75" modified="2018-01-31" version="1">MSEKGAITLYYSERVALALEEGHIPYDTIGFELVDKPDWYKEKVYPPAKVPYLVCGGPKLQPGDAPPPDVPQLGELLVILEFLADAFPSARLLPPNPFLRAKARLFCRAVEEKCYPAFRAVFFKQAPKEDLYAAVEHIQGLLPPDSGFAVGEWSTADAVFLPVYLRWTTLMQRYLEESMARLSAKKTWDLASVKPKLVRRLDFFLAQAQKGQQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3C6</accession>
    <name>A0A2G8S3C6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSI_09564</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The aspartyl protease (PR) mediates the proteolytic cleavages of the Gag and Gag-Pol polyproteins after assembly of the VLP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S3C6"/>
    <dbReference type="OrthoDB" id="2742630at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025724">
        <property type="entry name" value="GAG-pre-integrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13976">
        <property type="entry name" value="gag_pre-integrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0229">DNA integration</keyword>
    <keyword evidence="19" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="17" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="17" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0815">Transposition</keyword>
    <keyword evidence="3" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="18" id="KW-0917">Virion maturation</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="24">
        <location>
            <begin position="502"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="235"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="763"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="237"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PIL28276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1288" mass="143519" checksum="4A01D52277C9723B" modified="2018-01-31" version="1">MTTATDAAAQATRVRIDPLTGVEDWGSWSVQMEDLLYGLGLWGYVKEVNKPKPKDTEKPTKEETEKLDEWRKLDRSALSAIRMRVSKSLVHTLKWCTTSAEAWSRLEKNFEPKGILHVVQIRRKLLQAQYCESDDVEEFLRVMVGLRESLACMGFDLSEEEFSITLLTALPESWDPMVSSINHTRDLSDSDEIVSRIRQHASRINDSATALFARSSGKKKGPKCFKCHGKTGYQRDCPNHDSRKGKGKGKDSGHGKGKNEARGGGKKEKKEDPKALVAEESDSDSEYAFALLEEWDDSDSDEVALAARVAADAWVSDSATTVHVARRRADFSTYEPTPGRTLKGAGITPILGVGDINLEFEHEGRKTVIQLRDVVHAPAIPHNLIALGRVEAGGHKITMESGMIQFLNPKGQVYASGERVGNLYVMRAAVVPGKPADVACAAAVTRPKRVRTYDEWHRVLGHIGMKAVISMKKKGLVEGMEVDESVEPSQQCESCVRAKQTVAPYPKKSEMVVEAIGDLTVMDLWGKAPTTGIRGEKYFSTFTDMHSRRTVIEFSKTKTDELENFKAYQAHVQNVHGVKLKKIRCDNGGEYLSKDFTNYLRAEGIELDTTTPNSSAQNGVAKRVNRTVMDRALAILIEMDLPKFLWPEAVAHVAYLKNRSPTRALKDKTPEEVWSGRKPDVSDLQEWGVKCWVLTDRKKRTKLELKSQLMRFMGVAPGSKGWKYYDPKARRIGKSRNIIFAVPKRTQPAPDSDEDEYDLIELSTPTPLEGENVTGGEQASGGDRAPLTAQSTDAPAPAPPSKPTPVAPEPRTLRNIPRIDYKASEDGRGKVIKALTRAPVTTPSRDEEDEVEQLIDDPESHFLCLLTLHGTPTAREPRTFKEAMTLPEADQWRAAMDAEIAQLQKLGTWSMVDLPTDRKAIGCTWVYRIKENLEGEVKFKARLVAQGFSQIPGYDVFDTFAPVIRTDSVRTLLAIGTERNMEMRQFDVVGAYLNADLDEEIYMRQPPGYEDGTRKVLRLQKALYGLKQGGRKWNIHFNRIMVDELGFRRLNSDPCVYLRQDKHGLTIVGVHVDNMIALADTTALMDAFAAGLAKRVKITDLGMPSLLLGLEISRDRPSRTLSICQSQYILRVLERFGMADANPVSTPLDPNIKLVKTPDDADLSEMRDVPYQAAIGSLMYAALGTRPDISYAVQALSQYSSRPGPEHWTAVKRVLRYLKGTHNYGITFTGKGAPRLRAYYLNLRLEGYSDADWGSNPDDRRSISGYAFLVGNAVVAWSSKKQTTSGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3L5</accession>
    <name>A0A2G8S3L5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3L5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3L5"/>
    <dbReference type="OrthoDB" id="2801472at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="3"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="485" mass="55011" checksum="999F2021614A9A4C" modified="2018-01-31" version="1">MKVFHVLQVLIESPEFAFPTIHNKDSPILDPPAPVDELPCGPEHVTLQFMLGTLPTPEATYEDNDKVIAELLEQLGCRSISDFRKLSLERILFVIGDQLTVERIWGLQYLLCQEWNSHERLDFTVPVFGWLHFAMAFAKSLHKQYFGTNAGMGLKHAFTLLDRKGLDKRVTQGPFHDNLDRAFYHILEAHLCTCWLQVSGASSLQDLRGRTPEQLKTLAEKLVLEHASTDAMTTLKHGAGEQDELRLQTTMFLRDVLLYVVLDRAIKYGDVGLMEGILPHTLLRFAGGQNSNYTIECLEMLQGLHKEWPPEVCEFVRKHCWLVNTTGRRDGHTPVDRVQEARIKDIKVTHRSQGPNVDWQYVKKLHPAIPVIQAVSVHVEDQFKTWSRYSRHTSPGDAKGISRLQDAYRQAKVHISVPGRTINSGDEVSDVYNNGLLTLGRPMNNWRIARTMPRATEEDFSAVTTDALQDMVDMEVDEAGSPVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3L6</accession>
    <name>A0A2G8S3L6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_09517</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3L6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3L6"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013607407" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="21"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL28366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="35554" checksum="D492947FABAF126A" modified="2018-01-31" version="1">MFSKIGLAALASVVLVRCVTAQQPVWAQCGGIGWTGETTCVAGAVCTYQNDWYSQCLPGTATTAPATTTTSTSTAPTSVPSGIENANFWFSFGDSYTQTGFTTTDAIPVPGNPLGNPPYPGYTAVGGTNWIDVDTTVYNKSLVLTYNYAYGGATINASLVAPYEPTVLSLIDQVNEFLGQAADKPATAPWTSENALFSVWIGINDIGNSYYQSGDRDAFSDVLLDSYFGQVQQLMLAQSADAQALEKTVIAGYNSKLAARAQSFAAANAGVTTWLWDSNAAFTKVLDDPTAYGFVDNTSYGDNTNDFWGNNYHSSSAAQTIWGQGVAAVLNDTIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3P3</accession>
    <name>A0A2G8S3P3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3P3"/>
    <dbReference type="OrthoDB" id="2799179at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="58694" checksum="E90485641BC22E6C" modified="2018-01-31" version="1">MIFRDVSRRLAAPVVESSSEEFCPVTVSSVVQSLVLVDDCIEQRGGVSAFFHLLSGQLDDKLLTSPESPFFCPVFDSPNLHSSLAHWPCLRKLSLASSTPWVLHGLRWDTLKAMMSLPQLEEFSLHGLTFSPILATDATPEELEVPSLDHLTSFRYEAPSFRVSSWGTRESYPFPSEETMLRRVLEKLHLSVERLTLSSEAAPIDAMAQWEWPRLRELTLTGERWAEPRTPLLSLFSSMPYLRKLALDLSVVRGYLADPPPLWPCGHRAAFPWPDLTHLSLSNPHAEDEVFAHLPPALQSLSLCCCPHKSEKLLLDGIATIPHRYKYLVLDSSGMLGILSRCRTPRLAHLKIEYNAGDREHDLLEHLTAAFPRLTSLQIHRYRNVGNAGPQNPPVTTSDRTIDDVDFQAVESFGKSLALLASLRTFNAYLDYEDTPRPKFDRPRVRGFQYSSQDIDRFTATLHKAADVLARAMGPSVESVQLWRPRELEGYEWLAFRVVRASGPAGVEARCEEDWRVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Q1</accession>
    <name>A0A2G8S4Q1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_08751</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Q1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4Q1"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="4">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="4">
        <location>
            <begin position="244"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="3">
        <location>
            <begin position="604"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="768"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL28707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="798" mass="90066" checksum="147649959A0DB752" modified="2018-01-31" version="1">MDKSSSVAAAFHAGKFPSQQQISKAIDSALSSPFLTNEPFDEVGELTEQGRKLQDGFRELLLAYKKLGENKNADDMIQESLWHLSEVDLSSVSASLPDVDADQAKADSRALAHALRTVVSVFSENLAQEGRSLFHDFASFMRLSLADAAHHLSDRARGAADVLREVDREVEEGERSELGIKRKAQDQPEDTNTRARFERGMDTAKEVGSKAIGAGQSTAQATQELAQRSSSRIQDAFYQICDQAQSDKSYHESISTIFKLFDKWTKRCLDAAADMNQATSLDAFIDDPTPEKHLITAIRGFREFMERLANGKSLDGFFGALRVCGVDIQQDRDIRTWFDKLLAHLHASLDEPGFVRSEAAEKQREALHHEWEELVSEESEEGRKWSADFAALRREVTEFQRAIDQEEDIRELRRARARFAEDVENMLLATGTAGAHTFMDRAPWFWQDVFNVHLPRVVRSIKDIPIPRTEYKDNEVEFVLEDLDISRFSLLPGHAYIRNITDIDIKAPSPGKTDIAVGTLTRLYLQGLQLQLKEVSFYYNDKTTTMGPSEISGLLEFTIPPQGVDIDVVVRSIPNTPDGLRERERRSSFIDIQRVDVKVSEDAALAIKESNHPILVTLFRPVMRTRLREAIETVLRQQIRGTLEHLDALAWDVGRRAEVFEDSGLPRGASLVAGFWSELGHLRRTQERTASLLSGWRATGTGVVKEDRDPDVQFAMGVEPQVLPGEKHGPKGTFAETLEEREEVEQVEQAPGVVEQARERVKEKVRKVKSWQETVQQKTEMERQRPGWRSPAFDGLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5B8</accession>
    <name>A0A2G8S5B8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_09026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5B8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5B8"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013580541" description="Transporter" evidence="3">
        <location>
            <begin position="26"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="88"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="423"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL28979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="571" mass="60684" checksum="E686690351F8BE28" modified="2018-01-31" version="1">MPTPWKQNVAAVAGSALAFAGSALSVDPVGGKLGDLVLSKCTAADGNTVPGAECGYAIVPLDYTNPSAGVAKIALGRYNATASPRKGVVFVNPGGPGGPGVDLATSAGPYFQELVGEDWDILGFDPRGIGLSEPQTKCFLGNGSREGFLANTVLDRGYDVSPNLTDPGNRPHLIQTQRDANALYQAQFEVCNQTMGETIKYAGTTSVVRDIDYINTLLSGNNSLINFYGLSYGTVMGQYLVNVFPDRVGRVVIDGVVDADAWANKPPYKQLHSWLNSTDAAYTIFFQECSKTGPSQCPLAKEQNEDPNAIMSRVEAFVNGLYTKPLAVPNAQLPGILTNGRARLFILGGLEFPHGWPSIAKGLAAAMAGDGSAMLDTVNKDLVDLERSAVSCNDQRPFAPPSAETIVDAGIETLKSVSRFFWSVIISEPDSGCQYWPVTPPERYLGPWNKTLNNPMLIISNTHDPATPLVNGQLVHSYLPKSSALLVQNGVGHTSTALTSKCTIQYSRAYFANGTLPAAGTVCQVDESPFPAASKSTSSNAKTLVASVGGRSRLSDYIYRGINSKAMRNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5F3</accession>
    <name>A0A2G8S5F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5F3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="154" mass="17120" checksum="EE6C3D5426741A0D" modified="2018-01-31" version="1">MSSQVLALRGSEEGAEIPNQRTPSTCNIPRAKAKSDDRGARGRRNVRAKNGKKDTQSRRKNRREEGKGWWGPESEEEDEAGKNGRTVWSRGWGSALALTRTRSREPEPGRTGPASAHPAHVKWFAISLRWGESTHRVMNVPRKKPVSSADAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S625</accession>
    <name>A0A2G8S625_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_09275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S625"/>
    <dbReference type="STRING" id="1077348.A0A2G8S625"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="146"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL29226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="369" mass="38941" checksum="713E68486673D7B4" modified="2018-01-31" version="1">MLTAPYTHLPRFITKFRDLMFHIAWRPASILSGDFPVPFLTLCSADSLAARGAPQQSLGCFRQLPVVSPPLWTTSGTLEDFPKKRLMLGVAGRLLTNCSVRAVQVGGTLWFRRARLCSSSGKTKMVSSTAILLGAISLVAGAAAQSTAPQYGQCGGIGWTGATTCPDGWSCTVSNEYYSQCLPGASTPTSTVATSSGGSSPTSTTGSSPSATVTLIPGNSFIRAVEDPNFHQYLRSEVANTASDAVLGDPSTAAQFQITDGQLIQLLPDGSSLYAAVESRANATVMKLKMSWQDTPASGDAAGTFMWSGDTVEWSIASISRPQLNAWLVCPDEDGNKDVYINLGAYDYETPAGCADETIHAYTGPYATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6J0</accession>
    <name>A0A2G8S6J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6J0"/>
    <dbReference type="OrthoDB" id="10543590at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="422" mass="45214" checksum="73ABA51BF8F61420" modified="2018-01-31" version="1">MTVLENPTTTPYSIRRPHTSPVSANERNHHYLLNFAVSLAAILFGIAIIAAFALAVRWRKRTSQSYLLEPRIDTRMPQGSISDVSDGHSTISLKFPPPGLAPPRNPRDRLPFLPRSPPHAHHPTSHARALQTCQSCIAGPNNAPPCYCPTCPNGPGWDNPPAYRASAPSPNDIPSRRLSATLVNPHGANPPRPSSTDENSIRRIQRTPPAQIASRNGHDRPRSVQHSSTPAGHTRGGVTVVDEDNTISCFSESSSSTLSPSNASFVSASSRLDTSVARPSSPGLSHDAGAAALIYGRGPDATAGRGPLELPLAVYQDQSDDTSAYIRVTPPSQDRLDAHPDGPRYGRQTTAPESGSSWCLHGPSSSTAAVEGRDPLTGADGPHAREKSEKWFMDLDWFGRRSLSVDFNEHALATGRGFGSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S714</accession>
    <name>A0A2G8S714_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S714"/>
    <dbReference type="OrthoDB" id="3251181at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="830"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1067"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1114"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="320"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1090"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1135"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1160"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL29517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1778" mass="195355" checksum="D259F066014A21F4" modified="2018-01-31" version="1">MAEHRSIVPRGPILPIDVAQLVMDALYDASSPEDHCYRNQHTYRNWSLVCHAWRMYAQSLLFRIVELNDPASLRRFSAHLDSAPHLAHYVRSLRVYSRALFTPGNVFSVLPEEIKHKLPNLRVLAVTRISGLDSWHPLSPVPLSQPELSCVPLPDDFHTRLAPLSHVMTLKLYFVSVRCFCVLARILRAFHNLRELAVIEVHWNYWDLPAFMLKSASAEERDGFLPKIEDLTLTFTFPSALAEPAVGSPHTFIPPDRVRTYALSRLSVPKLATDGSNWVTYHARMTVVQAAKGHMPHIRGTARKPPLPPPVERKLPHVPPSAAAATTPAPAATPAPAAAATGGKATASSRPPSPTKTTSATPKPATDAYSHLTDEEYVELVEKMDAKFCTWEAKEADARALIYETLSDELFIEVQIQPTVKSLWEAVVASCENKSLMYANAIRTRLQNTRCPESGDVRAHLALLLRERQNLAAVGNRLGEAEFAAIITNSMPESYHSRIQSILDISSISGHTIPIEFLIGKLNEEYDRRGLNKANENALAAAAAAHRLGPSGGRPPVICYNCRGVGHIARNCRQKGGGKEGQWPKPKTDDAANPAKADANAATEKGFLALGNVVTSALAAVPGTYIDVFDSGASVHISPYRECFVKFRELNPARAITAANGEQFFATGEGDVEIRVPNGPSTQLLTLRDVLYSPSVAFALVSIKRVDEGGYTTIFEHGECHIVERSSELDIARIPLTNGLYQIVSRYVEVPSATAALSASSTRPGSASKKILEISQAEFHRCLAHRSYKAARNLILNEHATGVEFTDDAPFDKQCDICIQAKITRKAIPQHAHPAEHDLVITKYGEKFHSDMWDANAVSLRGNAKSVLFVDDATRYQHGFPLRSNADTDTAYLELEVSVLTQTGTQIKWIHSDNGSEFIGLQPHLKERGTHWSGSVPRTPEQNGVAERGHRVHREGVTAMLIDSGLPNSLWPHAYKHSVYIHNRMGQELLGGKTPYEMRFGVPPDLRHLRPWGAQVWAKLDNTRKLDPRARSGRFVGFSENHRDGINVYWPDKRTVTVVRSYIWALNDDEPNSGPEADVPGATDVQSEGARIEGAQEHGAQDVEGAPAENIADEQPQGVEQGEEEAEPEVGQGDGGRDDGDGAAEGKGERGGAEEEDGEVVERAPEVEASGRGHRVKRASTYVQRIQSGEGTIDGRNTRRLPRGVAPGDIMGVVAALASPREDGEDDQGTWAIPTASHDWTTAAHILVAEAAGDPLSCDPRTLREAQEAPDWAEWEKAISVEMENLKAHGTYELVTKPLGAHVIGCTLVFHRKQDAEGEVTQRKVRVVAQGFAQVPGIEFDQTFAPVAKPSSLRLMIALAARFGWPMVQLDVKSAYLNGELDEEIYMRQPPGTAAPGEEHLVCRLKKSLYGLKQAGRSWYRTYRDAMTSLGMTRCESDHACFWQRAGESLAMVGTIVDDMLVTGTPDLVEKFRVGIKKRFTITDSGEVAWLLGIEVVRDLNSGTVRVAQRSAIDAVARALHLEGAKSASTPIAVGGILDRTQCPTTSEAIADMAAVPYKQGVGMCMYIAVTTRPDIAHAVHRLAKYMANPGRAHWEALKRLVRYLMGTRDLWLVFGRDGSGLAGFTDADWGTSDDARHSVCGYMYTFDGGAISWSAKQQNVVALSSTEAEYIGITHAAKEAIWLRALLSELVHPDFAAHAVRLYSDNKGAMDLARNNSFHARTKHIAIRYHFIREAVERGDVDLGYRRTEDNPADIFTKPVTRGRLEHLRGMFGLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7K2</accession>
    <name>A0A2G8S7K2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7K2"/>
    <dbReference type="OrthoDB" id="2751344at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="107" mass="11567" checksum="094541EA5FF6171B" modified="2018-01-31" version="1">MQRYTNPEVFLCPYYNVPGISNPKMHMAKEGLAKSLPPSPDSAASPQDLTTLAPVQPSASTQSPSPSSSRDNSLSPEPSSPVPDAGSDSDRKKDDYERIFEELIDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Q7</accession>
    <name>A0A2G8S7Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SDS22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Q7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7Q7"/>
    <dbReference type="OrthoDB" id="266138at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000055">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF23">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="379" mass="42164" checksum="F54BB840FFEBF863" modified="2018-01-31" version="1">MSEPGTTSENNTATTVDSQATDAPNAAVAVPTETPAKVARVEVVRPQAGADGSSGEEDDGEDEEAAIEDSQILEDLPDETEDIELIHSRLNSNGVGKLGLPRFGAHLKRLCLRQNFISHLDLEVFGALTALEDLDFYDNKIKHVGTALNNMANLTTLDLSFNLIKHIPEELETHLTSLKTIFFVQNRISHIANLGGLAATLRSVELGGNRLRKLEGLEALVNLEELWVGKNKITKLENLGALKKLRILSIQSNRITKIEGLESLENIEEFYISHNGVQRIEGLENNVKLRTFDLGNNFVERLEGVSHLTKLEELWINDNKISTLQDIEPQLKHLETLETIYLERNPVQASEGAAYRRKLILLLPQIQQLDATYVKQFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S815</accession>
    <name>A0A2G8S815_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S815"/>
    <dbReference type="STRING" id="1077348.A0A2G8S815"/>
    <dbReference type="OrthoDB" id="3266915at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="530"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="628" mass="63973" checksum="599A8679738EED53" modified="2018-01-31" version="1">MLSSRPISFNGDVDVQQSILNAKTPGRKALKGRSVLQENALHNGAKTVLSKKNILQTPFRPGTAHGKKPLVSISVTRPLMDKTPFPNRIAAANFGGAGPAGKTPGATKLSKLALLVSEPPHHQHESLSPDVAPLLRPSSARKSLRGRLSGASFKTPLTKGNYWDVSPGDVDGIGGVAEDAKQETDMEVAVEVVDDEDDEIEYMPPTAIELPYEPAFAIPDYKAMGQALFALGHGGLVDDAADVYYAMDIEQQVDMKQLCADAGFTSASDLRDASGLELPELGACCLRDLPEAASLDLVIVAEDDSPFARKPKGTPRLAPVPSSQAERRPPTSKSASSIPLTRTSSTRASSRTQPAVAPARPATTTPPIQSRPVSTSTSSSRLPQPTIVVAPGQTRTSALRAAKAAAAATASASASSGSGLPAPKTKANAVLAAGQAARRPVASISSNTNATGVPAAGTKPKTQAQAPTHAHAHAHAQAKVQVQAQARPITIVRSVTSGAISAKAKASSNGRGDAMGTGTGTGVSAGTRPGTVTATAGTSTRASAGLRARSATVNASLPGRPASGVKGARGPGTGGKAHRDGDRDGEGDGDGDELATALEKAIGDAYANGRLGASASASGGSEDFVFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Y9</accession>
    <name>A0A2G8S8Y9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Y9"/>
    <dbReference type="OrthoDB" id="2739860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="451" mass="50417" checksum="9150811CB9E0F0D4" modified="2018-01-31" version="1">MSGLVATMRLVQQPATVVVEAKVAEAVEETIERTLSSPEFFAEVTADIRNLAQAVKDIRAGFRAVADDLVAFDNDEDKDKDSVVLRLRPQWLGYQAVYIRCHTGEEPPERTMIRQYTEAILTDVDPSKFEDVREELRGFLKKLDEKAPTAQQTQGDLEKLADDAKTHLRNVEKKFESISDEKAKLGIMAFSGLLLGGACAIVAMFVLVPNAGKQDAVKQIGVVGAGYCGVQGWLLHRQGTSKSSSLCTECGIEMKECRLDIANKKDRHRELLGHEAALTQTKERITALAEKLDTISAIWRVLKCDMQQLQEQLALVVDPDVQVTKRFLKKLRRPREVYNWLADLLELYANGKFELSFSLKTSFYTLVLPGLILSFLSNMHIACMPARTRRYRARRGTSTSHSFRGSTFDFEGTATSLALAFWPLLQNVFNTTTGFLTICDSLAGAGRDTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA12</accession>
    <name>A0A2G8SA12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07281</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA12"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA12"/>
    <dbReference type="OrthoDB" id="2740120at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="332" mass="37168" checksum="BF6886D31F06B0FB" modified="2018-01-31" version="1">MPPTAHRTRQPSPAVHYCYQCFLPQAATVQLKLCSGCRVAEYCSKECQKAAWPTHKKECGVTCKLAEATDPNLLDKVLHAFGFRTPVDSLKALNEFAQAHRWALEAHFHVAIRRKVGFKPAPGDITDSILVGNLECVAPPSSGKRLDPASRFRLRDRFKFVPLAEFKNASRERAEAFDRMYGESRATIQQFHGANLLFLGGCPVAYRIWPLSVVSFSCCPIFYAVHGPHNYDDDTRREIFEDKLRLATASINAGIVLRGVELRGHPVPGRLVRADKIWSFEPLFKADDWEDSWAAYLAADPRPKGVDLLDDAIARLKSGLPLLELIQVSQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAS1</accession>
    <name>A0A2G8SAS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAS1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAS1"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="13655" checksum="824D01B44A79632C" modified="2018-01-31" version="1">MSKRKGDVHVLDYARRGWEPNAILNWLALAGWGVQHDTSCLVPSSGGVSKQAPDSTTIMSVEEMIQDFDFSVVTHRRSILDPVKLEYINKHHLMQLMSSPVGLRTLAEHAQSFVKEAYPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB70</accession>
    <name>A0A2G8SB70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mug135-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0612 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB70"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB70"/>
    <dbReference type="OrthoDB" id="2757732at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013902">
        <property type="entry name" value="Mug135-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08593">
        <property type="entry name" value="Mug135_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mug135-like C-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="16199" checksum="B1C81490B72205C1" modified="2018-01-31" version="1">MQESIDQRFAEVNTRLDQMNARLDEMDARTTHDRDELKAITIKGYIIMITRENGAYQQFDELAEVPFPNGMFPWGKEVDGPNNTRVTLPELRSLDAIKNLTPPQLYGFFQGYYPGEPLPPTARCREKILFAIGRGKDLHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBT2</accession>
    <name>A0A2G8SBT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBT2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBT2"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="502" mass="57314" checksum="272C81AD70129D5C" modified="2018-01-31" version="1">MLRSLSSRLSGSRPWSPERGGSYDILPTNNSDSRHSHTHRHSSSANPLARCCTRPIIRLLVAGSLFLFTLHFFFGFDYLAAEVSRDLSALNPNRKPPLYTDYYLQELQHPQHNPNLPYPEGGHGRYIWYANHVHGSGWGNAMQEHLFNAYLAHEAGRAFVYNNYTWNDDGSDYTDYNGHLIPSRIPIAALLQGPTAGGSWPSGDPTPRAVVKEYWDKVCPEPHAIVSDELVDAAQVDADEVLRTWVEKLKTLPGCVEITGTQVWSIWIFGSKRILTIWDALKKSPIITRFRWSKLIEDGFMKNRRYFTDTSWLRDFFWSPVYPYDVIPGLLVLHIRRGDFEEHCLHFARWGSQWNGFNQFPELPDQFVPPTPAGRGQFTEEGKDIYLRHCFPDIGQIVARVAEVRATPAGQGLKHIYIMTNGKSLWLDDLKKELAKLGGWDKIASSRDLQLNWEQQFVAQSIDMLIGQRAQVLIGNGFSSLTSNIVMLRMAKDIPPDTNRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCE6</accession>
    <name>A0A2G8SCE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCE6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCE6"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="289"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="766" mass="84158" checksum="875A7DBCE0E4F959" modified="2018-01-31" version="1">MIAEVLLVLAGHSSSLFPTDHTVHPAFAPLLHPGEEQCLESLGQIAIRYRKIKQACTVLARPSSRYVSALCATLNKILRDEYEVLVVETEAKVLQRDSSLVASGSFVPLSSLRAIFAEWDAPLASLETLVDDLQTQEHWRPGPLIDLLLTRSQTGIHRVSSIYARLSEAVQRVWIAQLQALLIHGTLSPNDPLADKNYVLVEGAAPSCVSAQSRESITYVGRAIGTVKAAKWEKQFPQDLAREHTKLLITVIPQDQYAFDRVIADIRTAVSEWLWLNVLTHKDVDEAVESLANYFLLRNGEFALSLIREIERLKLSRLTGRSVPSTMIREQDLHLALLRASLGTTAQQDASLAHLHFRLPTGPIRPLLPSLAGGAKDLSTSLSSSTELTSFDDLLLGTPLLLTYSVSWPLDLFLHASDLQLYAALFSYLSALRKTHTRVHTCWTALSNAQRARRRWTGLGEGGTAEDLEVRKQLLRCGWGVVREMNWFLDTLLGYVMTDVVDVEFRRLKSLLSSRPAGGIGRQMTGSGPSGTAAGAATDTIGAVPLGASKSGSTIHPSLSTGSNLSSGAPPLDFTTLRSMHTTYLERLLTGSLLTNPALTNIIRMILEVCERFAAQVERWGGDVLPALLFEGSIAAGGNRVGDMVAERYAIVGEIDETLHSLLDAFYEQLSLSTTLQPFSATADATKSALYNASMTNTTGFGFHTFVRVRRGKRLEGDEEVRRHVERLLLRLDFNGQFSKPSSRRRGTRQTAAHEQEDILKQGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCF9</accession>
    <name>A0A2G8SCF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCF9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCF9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013425148" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="542" mass="58711" checksum="E7717B302B719516" modified="2018-01-31" version="1">MMWGGSLVALLSVASFLFSSDASGTSTSLVVDTTSGTFRGVANTTGIDHWLGIPYAEAPVGSLRFKAPLPFTKRSAAVQNASTFGNACPQAPSNLGAPQSEDCLFLNVFRPSNVSAASKIPVLVWIHGGAYMSGAASDPEFDPTFLIQRSVAIDKPIMFVSINYRLNTFGFLASQHVPASDLNAGLQDQRAALEFIQENIAAFGGDPTKVTIWGQSAGAGSAEAQVLFPSSKDLFRAAIFDSSTGPFKTAPPASTYDKPGLPYDRLVNLTGCPSGAASLACLRNLPFDVLQNVSVTMTDQVLNSQLWQPTVGPAGSFVPERPSERIASGNFLHVPIIAGTNLNEGTTFSESVRNLSVPASEEDSVFDTFIKNLLIDPTTVTEDVFDTINRLYPANDSSLGGPFNTGDSLFDRAEAWYADNMFLSARRLLFHRAASLQPLFGYFFTEFIPGQDPTLGVFHASELILLFGHFPAVEQEFATQMITFYINFINDLDPGAPWPRYTESSKNVLQLMRDNITAIPDDFLIEKTNFLDSVYVLSEFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD00</accession>
    <name>A0A2G8SD00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD00"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD00"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="180" mass="20541" checksum="F72F5C1596C2D772" modified="2018-01-31" version="1">MRPLTEEESKTVFTKLANYIGKNLVHLIDRQDEPHCFRLQKDRVFYVSESSMRLAISVARPNLVSLGTCFGKFTKSGKFKLHITALDYLAQYAKYKVWIKPNGEMPFLYGNHVLKAHLGRITEDTPEHQGVVVYSMNDTPLGFGVTARSTVDTRKLDPTAIIVFHQADVGEYLRDEETLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDW6</accession>
    <name>A0A2G8SDW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06653</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SDW6"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cDENN" evidence="3">
        <location>
            <begin position="572"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="911"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1175"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1195"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1206"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1275"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1387" mass="149992" checksum="87AEDB2185DB7B09" modified="2018-01-31" version="1">MHSPRTKAKPPMQPLAVSATPGPPVGEKITKSQSRFSEDENAKTNPTSSILSRRTTVKSNPSMRSVSMTSTHSNLTVNANPRATSPVGAGPISSAGGRRGPRAIPAPDPIITISGSGGSDKDKDGGGLFGSGIIQGQARGPSSSHGHPRSSHVPSTTTSSFHSALDDDFEYVTVEHPPDEPELAHAVVPARTDKAARILGLRHQSMEPIPGSNRNSVASARSAPPISVSAPPPTQSGPTLPLASLYVVSGLPKSPQTWTLADPDSVMGLHHSEGAVGRWWRPEVLGSTISPGAGGGGKRKKKNKADEASTMFSSSGHMSKQEVGKMLSKALKLSFTREVEIIASTLQPASTVHNFTFTLPAPSTPLAPSPSTDVLRASVLTTTTDVSYAYPYADDPFTRHARPSSAYLGPPSAFLMANGQSASARSQPELGSALNGSGAGGGQITYHGVCLTVWSHADAERSAAIRRTLEAGRARKESAQSSLVRPGSRRTGRGGASASEATSDPAMQARRRAKLSGRGPWGGAGTDAETDLDPETDGEGGGVSESDYEVASTVGHTPGESTLFLPGDAVFWLPYALTLVSRFPIYDLMRDYLTLSWARFSKDVQSHTLQISKILSHPAPRPGELVRLDASSTTAGPSSHAGASETSLEVVARFPGGLDFGRGLVDVNFTMWPLFKCLNIDNILTICEIALAPTGRILFYSRHPAMLGIAVLTIKYLVELRGWSGVALAAVHSRDAKIYIDDPGPWIIGLATEARYAIRTPPEVCVVDLDINYLNCSSPPPGVVSTKQQRDRFRQRLLAAFEPHYHPDHCVPSEFKEAFPAGRFRPVCKIQAKRGVVSTAVADMVKPPEWWHSTRIIQAFDSVLADKMKKPSLLKRISSFGTVRAPPRLTVAEQHIQLSIRKRASAFVDARDDLETKIGRLSRRLNFLMTESDLWRDKFVTFEQYAEKLSVEASDLRAKINKEQKETKRLSSMITMTAAEKSKLQSKLSETESAHRSALEELETMRSQMERMEEERTEMIAEVEAQIERALAHMAVDVDDSDYGGSRPSSRLSTRSAPSTSGGYRFPGDTRTRPLRSFSTESTLAESFAHGDDLIKTERVTGTVMEEEEDLESDERSKGMEKKKKRFSAGADVEHHDGMKAVDEGISQKSDKIAQKVLQIQRKLESALASDAYRRSLESHHSESELSESTNRYRPQPRKSRKNRSISDSPAGTGRSTPLSRTTAKDASYSMSESETKTEVAEVKPSRPQVLTSQQSLDVRRIPSTASISAISPTVRTPTTPSLTPGASAVTDDEETDFQSAYSTSPRGSNGSLDHFAVQTYDPDEQHSEQGTPTSITIKGTGHLDEFGPQRDATFKGRERNFSTSTATNAKYRLKSHTSEDTVGGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEK4</accession>
    <name>A0A2G8SEK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEK4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEK4"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="568" mass="63057" checksum="3D78E46BCC9DF2EB" modified="2018-01-31" version="1">MNAYWDLVLLCVYAAIVAHQIFRRYETYSIAFHSVMLIGPPAIIGAVLWTLDCLPVEMPALGVISLLYGTYLGVLGVSIVAYRLGPWHPLASFPGPVAFRTSKLWMAGCAAAGRECFVVKALHEEYGDVVRTGPNELSIRDPSLVGRIMGAAGLQKGPNYLGMTLTHDGLPMVGIQDVDEHLRRRRSWNRGLNSAALKEYEPLLAGRVAELARLLPTLQEKVIQLDDQFAQISHKIMSDMAFGENSKIMEGDQKKFWAQLDSGVIFAAFFSHVPWLGFYAMLIPLVAGPLQAFLGRCREFAIKRMLQGSEKRDLFYYLNHEDQPNRPSPPIHQLVDDGVLAIVAGSDTTSTALTSFFYCLLTHSEVYAALLQEVDNCYQDGETTLNTARHGKLPYMDAVINESLRVFPPAPNGSLRQVPRNAGVHAGTIFIPPGTAVCCHLYSMHLDPGNFSYPEVFWPERWLLASGKIPSATLPRHAGCDSEKGLGSFAASALNHNEVAFMPFSYGPMNCVGKNLAMAEIRMVACTLLRQFDFRLQDGWDPAEYRRGFKDYGIATRPRLPVTISRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SES5</accession>
    <name>A0A2G8SES5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SES5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SES5"/>
    <dbReference type="OrthoDB" id="2535105at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="181"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="328" mass="35882" checksum="EF755D7EF20F4C39" modified="2018-01-31" version="1">MNQTAAAAETAFLLAHLNRGGTIGVSLIGVAVSAMIYGVTCIQTFQYYRSENYKEDQWIVKTLVPVLLVLDSTHEIFIIHIAYHYLITNYGNPQSLELVIWTIPAEIIVNAVIAFLVDGFFCVRVWKLSQNRFATGICAFATVTHLATNLLYPIRIFAFPSLLEAETKLKATGTSGLGVGVVADVSISTAMVWSLTKEKIRSLRTASMVDRLVMLTITSGLLTTVFEIVDLIAYVVAPSLLYNLFFNFLLGKLYVNAYLTSLNSRDYVRGSNANVVSLNSIVLSSIQMQGMETAAGQTMDSAPGRTMVGTVEDNCGSRTDMNKTGWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEY2</accession>
    <name>A0A2G8SEY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEY2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEY2"/>
    <dbReference type="OrthoDB" id="3342934at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013883350" evidence="1">
        <location>
            <begin position="22"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="198" mass="20615" checksum="97591306A684C5D2" modified="2018-01-31" version="1">MQFSLTTALVVLAAIVGAVVGAEMHTVRFNNICGVGTPMLIQGEDVLSHGEPYTADGPLNSTIAQVGGATPDNSAHERHYRPTDVTICPGECGFNGENCTLIETALENLSPDGSNSGSLTDINVRSPHKFNVAASFSYVGGCEGDGAFCNGPNCNPAPVSCEVDNVNLTITFCVKPVPRAARLGAARYFAKMGPGRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF19</accession>
    <name>A0A2G8SF19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF19"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF19"/>
    <dbReference type="OrthoDB" id="3249394at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase RNase H-like" evidence="8">
        <location>
            <begin position="105"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase zinc-binding" evidence="9">
        <location>
            <begin position="499"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="402"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="67484" checksum="839DBBE3EDBF3C76" modified="2018-01-31" version="1">MKILGRIVDDQGIRMDPEKVDNVLSWKVPMNHELLRGFLGSVGYLADNIVTVQIPMGILSSLTGSEISFKWEFTHQRAFNEIKKLLHAHREHHCVPLDYSKDAARIWLVTDGSHGGIAGVVTQGEDFRRGNVAAFFSAKLSSAQMNYPVHEIEMLVGIESMRRHCDILLGCSFTWVTDHKGLIHLLKQKNLSGHQARWLECISEFDFTIEYVPGVENVLADALSCIYAHDRPGTVRAPSKYTQFDEEGDFSTVLQSFAISAPVSVDPESLVELEKPDLPLVPPGMAGGPAAEPRVIGRGRPQQKDKTPAASSSWGEGKTDLEGKSATKAAPGPGETSHEKPRPKAHPEAPVTAGEATVCPARTCPSIPPPETGRPETAKEFVKRVKRVIFHSPRVGQWEGVQPAERSSEPSQQPEISEDAPIPPLMTQESQFLEFLADNTEGIDLLRALQGRYSENKFFSVILANLKHYKNFLVKDNLVFLRDSKRTLLCIPNVLVNGRSVRELVIHHAHSLLAHLGAHRTLSLLRDHMWWKSMVSDIQAYCDSCMTCKRIPSKPWEAIGVDFVGPLPESWNRDGAFDEITTIIDLLTEWCTSCQVGKTTRPQRLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFG2</accession>
    <name>A0A2G8SFG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFG2"/>
    <dbReference type="OrthoDB" id="2734101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836172" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="15068" checksum="E538C84633AA8EE2" modified="2018-01-31" version="1">MKFAFALVAFAASALAQHIEIGTPNNFAEVKAGSKITVEVAQPNSLSASTEVGIAIGLWPCGGPKGTSKCASTDVSQVLGSVVYTGSYKSAYDSAQPSKPPHQNFEITVPSSFSKGEVSLGIAHLFLVGAGSEPVYEFVNTTLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG85</accession>
    <name>A0A2G8SG85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04896</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG85"/>
    <dbReference type="STRING" id="1077348.A0A2G8SG85"/>
    <dbReference type="OrthoDB" id="2801180at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62456" checksum="D83A912637513675" modified="2018-01-31" version="1">MTSAILRAIASPAVLAQIFSQLSPGSNEFEDPDNADYEEERENRSSLRSALAACARVCRAFSGPALDAQWKVLDDVVALLKILPHTLTDPDDDSGPEIDKDTNTYHLNVLNLSSKIDDIEWARLREVAQRVRELNACPPDCFIHPGVWTTLATRLQGTPLLPHLRCLHISVIYNDPTAFVLCLSPTLQELSFTAVDAGGHPMPTKGEFVDNIVTIISATEELPFSSYRQLTPLAPECTEVIAQHLRSIGRLSRLEVLNLVPAACRIGIPALRALSTLSSLHTLRLVVPLKDEDKDAALSLEGLAAVRHLHLSGDVEGIRRVMAALPPSGLRHLYLRISGSKFKDIERDFGAMRHNIPTELESFECVFFGPISDDARPLLRLFNAFLKFSHLKYFAVHMMMGNGVHLSDSDLLVFGSRWPDLERFAVVSWELPNLKHAARKHGRPTIAGLIELARSCPRLHLIRVPGLDVRTLPAASAMPEHGHLLLRYLDPHVLVNDKKADLDEIARGLDDLFPGLVDVPQKYIEYNATEESVSWDKVQALMQARRAARREAGSDTARGDHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGI5</accession>
    <name>A0A2G8SGI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGI5"/>
    <dbReference type="OrthoDB" id="2756545at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53883" checksum="9E98B92E601B2590" modified="2018-01-31" version="1">MSDFSPMVNPVSSRLNERWRLPFDVMSGVMAVSLRSTISALMKTCRTLYKEGLKHLLRDGVQLAWTPDIINFATFMLNEDPPRFPYLRKLSLLVPCLSYNVGVHLVQLLSHPFLALETLVLRPAQPFLGGIVHPVVRNAFSRLTTVKYLVAVVVEETTAGSIRRLPWALESIAIGVEPGIRGILPIVAPFSGTLRTLLIKEESFGIYPGPWYSPQAVGDHFPTMFFGADPQPRRFPHVHTFGIVYRECVTDLLASAAFADAFPAIAHLQLIPPDPPTTDLGRVWHPIELPFPPIPRQSRKLSWPSLDECSGDLRSLDALHFDCALSTLRLWRDVRVDELDVLRAVLKDARPRCLCLSMALADAEPLFVALHALQAPPERIDVRIIVTEFASHLTGPSTIPQSSAPSLKYSYVESQRDCVSLTSFSTTITRLVSDSDFTAPSLKVNCRLSAAEEDGDWQWPDLGQRVYRKPGIDLDAEDGRDGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGL5</accession>
    <name>A0A2G8SGL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGL5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGL5"/>
    <dbReference type="OrthoDB" id="2746915at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="203" mass="23035" checksum="0A74465DEF0D5676" modified="2018-01-31" version="1">MRVFSINTPLIVEMGNEDLKAIANAWPLLVGLLLLDGWGFVNLPEVTWAGVAYVLHKCPQLITLSLSLDTRIDDVALMTSLPSFRPNMHLRFLSITDSVLDEVEVFVHSLFAIAPLVVGIDGWGHESEMLEISVPMANASAFLDQVESLMWELRRTRMRDQFAFLDGYVRNEAEEMNPFSTHQPARRFPYNKGRDRRIMGFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH27</accession>
    <name>A0A2G8SH27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH27"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="102" mass="10677" checksum="9CCA74640E42097A" modified="2018-01-31" version="1">MSVAVVAICGASGVGCGGGIDQREECEHSPKDFFRLDLDIPMHSALAREAEPPTGVLVHVIGVAQRLDECLSPLLGRIYPLPSTRFVSHAFALIGSSTAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHG6</accession>
    <name>A0A2G8SHG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_04662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHG6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHG6"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="125"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="183"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="660"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="912"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1033" mass="118259" checksum="3744499F9923AC5F" modified="2018-01-31" version="1">MSAALNAQADTSAQSSGTVPDISLGSFTSTFSTPARKLRIPSTSTGTTAVSPPNGSFSKRRAEEATPISKRFGHAHDGEEEEGDVLDTPDARKGSEPWGDATDVSAPGRPKRTRSAGSKGGINLTLRDQEKHIDALKKENFNIKLKVHFLEERLAQLAPDQIDAALKQNINLKIEVQQRGMELKKLKKLVLELQRELDHLQRAGGAQSRARELEEKLEERERELRELRRRRGVGPDDGALRELETRNAELEEELENVRGLLEENTEELERLRELAESRGDHSSLGSERWRRQAEELEGENEDLRARIDELEELVTQRTDERDDVADEVEALKLELEDMQRRREAESIERSESRAQILEEREGREAVEEGLNAVRDKLAAAHIEIQQKEDEIEMKNREIDELIAEHQRIVESVEDEWRGEVDEAKGQMEELRDALEQRDAECKELRLHVDEYEANAEDLHQKFEATLLHLEREAEEKDNELEAANRDLEATSNKLYAFEEENERLKEEMNRVQEDEAHERDRLEQLAAALKQKVASLKADLQELTDLYNVRDAEAQEHRARKEELAQHIEKVVQELQRERGVRERLEGDFDKAEKDHEDALRQERRAMEAKESALQSALNDLARTQSLLTQREADLVAVQTALQTLEADNKKLGESHTTARFSLQLEVDRLRRDVERLEDELARARKELDDREGKGRDRDGVIDKLHAENRDLAAQLAAQTQARLNVSEKLDDAQASLRSSEAETTNLRMRVSELEQRLSKDQRSLLTAEAQYRDQLTERNTLLLTIYQYMDKIVGVDKTPKKHGQAETKPFTNFTVFHDNLITRLKALSHIQTEFEKRVKEADQRYSDKLADMRKQLDLRWKQIDKFEASVKTLAEAKAVWRKKLSAKDGEIEALQATNSALQAHVVTRKGNQADSMEIRALTARVQNAERRAINFQNQLAQSEEKLTLVNQKTTAADNKWEARVKEFESRLKIAEEKVKRERQGGNERASDLEKELKLLQRQLEVANKRTSTLNEIIESAGLSTKGSPGPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI66</accession>
    <name>A0A2G8SI66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI66"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI66"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36091" checksum="8670C7A33743C536" modified="2018-01-31" version="1">MANTGGPPPAPSPPVAIGYMSSHVLAQLDAHRFHHEKQGISPSSIPPLIVGVQGPQGSGKTFLTSILRDSLQSAPHDLSVAVLSLDDLYLTHDGLVALADAHPQNALLKGRGQPGTHDVPLGTQLLNKLKRINDASGVGVQVELPSFDKSLFGGEGDRAPSGAVVRSPVDVVLFEGWCTGFYPISEEEVERRFTAPVTGLGDTFFETRGYRVEDVLDVNERLKGYISWWDLFDAFIQIKPPDEHPYTHIYQWRLQQEHNMKARNGGIGMTDEQVTVFVDRYIPGYVFFGDGVTEGYNEAPGQRKVPPWIGHGLRVQIGEKREVLSTSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIC7</accession>
    <name>A0A2G8SIC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIC7"/>
    <dbReference type="OrthoDB" id="2562239at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="41286" checksum="2D1905FFD449D30B" modified="2018-01-31" version="1">MSTNATHEFPAPVGGIPDALDFAPSIVFATLYAVLVPVAIWRISHPRSRTTVLLGTTFFSIERVVSYSLRANAARDAAFRANEGIETYLQTTYSSGFIAIGQDLVNLLRALLVASTLGGDMLTHHKLTPPHVRKAQKQARKERQIGSEMELAPRFPAGNNEQGDKAYKAGVEVEVEVEVELEMGTADRDGASSKTSANGPEFADQTKLRKTIRQWLGVATLLFLLAVIVSATAGGNYKVAVTGSNGGLVRALWYVSTVLAVALLVAAALTALVASQKLPRVPRTSALWIVIVACLLSIVGIYRLTAISHSTTSLLSTGPGTQNSPRDKAAFYVLHAVPEFVSVAILVSLNARRVFGTGPWGDLRARDPKPKAAEVESGTPAEAQGSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ72</accession>
    <name>A0A2G8SJ72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ72"/>
    <dbReference type="OrthoDB" id="2607755at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="247" mass="28034" checksum="C7460064FD935294" modified="2018-01-31" version="1">MSRPKLFTAFRRSFFGPRSLRSQGINIENVKPVYDSGGLPWWARFTYFLVVADLVTVTTMCELSWNRWTKWEELSPQLSDSAPPSSNASFSLATSEPKDPSQVMGHYVLRPRWQRGFFAFTTFTTGIVLGAVLLGGRSRIVRRMFVLPAPQRSNTGRQVVIQSALHTKSQGVVIPLKRTKLVQSPEPTEMMIGLKDGRGHYSLGLEKAEVNGERRTLWEARKLMFTEWYGEKKGQQMFLNSSRVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJH1</accession>
    <name>A0A2G8SJH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03632</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJH1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJH1"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="408" mass="43242" checksum="19A10654DF68B08B" modified="2018-01-31" version="1">MSSNVSAQPRIAIIGGGLGGLALLLTLHRRGVPATLYERDPAFDARAHLGGSLDLGWKSGQRALRENGLQDAFDNNSRPEGEEMRIYDGAGKLHLQLGEGHHARGPSKGKEDIRPEIDRTVLRKLLLDAVPPSLVQWGHALSSVRALGSGAHELTFANGATIACDFLVGADGAYSRVRPLVSPAVPEFLGVNGAEISLAPETTQLPALAETVANVGKGTMMAMQDSHILGAQVNGDGRIRTYAWFRAPASWTIPASDPGAAKAVLRERYAGWPAWMLALVDHCDESAIYPRALWTLPVGHKWEHVPGVTLVGDAAHLMSPFAGAGANLALLDGLELGLALADLKEKGKLGEAGAVSETVKGFEENMCAMAGRVSEKANANLEVCAGPDTPQAMIRRFREVTAEGEREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJV4</accession>
    <name>A0A2G8SJV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_03752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJV4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJV4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF648">
        <property type="entry name" value="ABC-TYPE TRANSPORTER ATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="77"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="389"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="551"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL34043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="609" mass="64664" checksum="4C0D4D2F49197832" modified="2018-01-31" version="1">MIVAMRVVRGQSKSSDFVFFITYLAQLYGPLNMLGYLYRTINQSLVDTERLLKLLSEPREINDKPNAPDLVIETGSIEFENVNFSYDNRTTALDGVSFKVPKGSSVALVGESGAGKSTILRLLYRFYDLKEGEGRILIDGQDIRDVTQASLRKAIGVVPQDPVLFNSSIAYNIGYGKFGATQEEIVAAAKAAQIHDRILSFPDGYDTRVGERGIRLSGGEKQRVAIARTLLKDPPVLLLDEATSALDTSTEKDIQKALQNLVQGRSSLSIAHRLSTIATADLILVLKDGRIVEQGTHAELLAQGGVFAEMWADQVSSSDGASAHRKSAVVAGFDVETAPEDGPTETRDETTGTPQLGTEEVAQDPFADSEATAVPEEAVADFSSAPVAFPASSDKDLPAEPSVTSAEQDPDVPQPPSAPIAFPSAEVSAPVAFPSESTDSAAAPVAFPTSSSSPAPLAFPTSAETSSQREGSVAERGPGVTFQDTQTPERTGTPDPEADGKRRRTLSTQGIQRLARRISITTRRQGSATNIPSVSIPSIPAIAGSISAALKRQDTARSSTDEGSVRDGAVPANLKDSPSASVSSEVGKPKGSKIKKEKKDKRKSMPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK42</accession>
    <name>A0A2G8SK42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK42"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK42"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF90">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="4">
        <location>
            <begin position="57"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="708" mass="76643" checksum="47A91BB8403414B5" modified="2018-01-31" version="1">MVPTPINHAANRYPRLTYSLLSLATHGLGKLAGYSRQDATDYMHSFVKREPEFERENKAQFIVFVVLIPVLVLLSGLFAGLTLGYMSLDETQLHVLSISGTPKQRKYAEKILPIRKNGHLLLITLLLANMVVNEALPVISEPVLGGGVVSVVVSTVLIVIFSEIIPQSLCTRYGLAIGAQMAWFVRILIFAIGIVSWPVAKFMEIILGPHHGIMYRRAELKELIALHSATGLLGGDLQSDTVTIIGATLDLQEKVVRQAMTPLDKVFMLSINSKLDFDTMKRIGDTGHSRVPVYEEVEVAVVVPHAPAAVRRPSLSQSGASTPPKGAVVAGDAPLPDRMQKVKKIVGVLLVKQLLLLDPKDATPLKNIPLNPIPCVPFNEPLLSILDKFQEGRSHMAIVSRFSVEKAKSVQQEVKKGLTQRLKDRVGMGDSSSSDSSSDESDNETGGASASDHDGSEGGKKKRRWGRKGGKKRKSSKDDVEGKDKLDDVELGDLKKEKQSLVQTGLAKALSIGREQSLPDDAVLAKEQADDFIASMDPYVMPLGIITLEDVVEEVIGEEIYDEFDPEGHARVAPHISPDAKRFFSRLRGRSVEPSTSARPEGGLTAATEPVPRGAQTMPASPNLLPQSMSNSPVPPSASVDIGSSPSKKRGLAGKLFGQVKRANTIDVPPSAEDQSQAPAGDTRPEDDKKDAPDKDGDAADEKKEQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK49</accession>
    <name>A0A2G8SK49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_03841</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK49"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK49"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="68"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL34130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="601" mass="66111" checksum="C5E309694F355C7E" modified="2018-01-31" version="1">MSVTDHHDLEAASPPLARIDSRKSKAASSVDVDTQDLHHGSSAPPVGALPVPPADKKGLHRALSARQVSMIAIAGTIGTGLFLGTGRSLSQGGPASILLCYGIVGFIVYITLLLLGEMATQYPVAGSFNAYATRFFSPSYGFALSWNYWFNDAVSVASDLVAAQLVLQFWTTSHTWVVSLIFWVFLVVVNSVHVRAYGEMEYWLASLKVITVVIFIILGIVVNAGGNQAHEYIGARFWHIPGAPFVGGFGGFARVFVTASFAYGGTESLGITAGETKNPSRNMPKVVKLVFWRILLFYILTILLIGLNVPWNYPNLSNKETTTSPFTIVFQMAGSRVAGSFMNTVILTSVLSAGNHALFAGTRVLYGLSVTNPPQAPTIFSRTTRSGVPLFALIATSSISILCFGSSFIGSGELWGWLQNIVGVSNQIAWVSIGLASWKFRRAWVRQGRPLSEMKFRAAWTWPWGPYFVVISVVAIIIIQGWTSVIPEFSAVDFVSFYIEIPVMILMYFVWMIIWPPGPPSPPISLPTDEEPVEGGAPARKSVGRRVWEFVSHNDAVDILTVDLKRDEHEENVEDLEDDLEREGNLKGRYRWLWRVYYAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK86</accession>
    <name>A0A2G8SK86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_03892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK86"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK86"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL34181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="504" mass="56810" checksum="991B173E1F25DC50" modified="2018-01-31" version="1">MPSDSLMPKSDSFNARVRGASHIDFKTSTTGVAAKAMRNELSALVTTVKDSETRKAFDTEMQSFFYLFTRYLSERARRQELDWDRIKSPSEDKIVPYAKLSSGSPANLNKLAVLKVNGGLGTSMGMTGAKSALEVKDDMTFLDLTVRQIEHLNTTHRVDVPLILMTSFNTHEDTLRIIKKYANQQLRITTFNQSRYPRIFKETLLPCPHTAEDEKKHWYPPGHGDLYNALLHSGVLDQLLAEGKEYLFVSNSDNLGAVVDDKILQHMIDSQAEFIMEVTDKTKADIKGGTLIDYEGSIRLLEVAQVPNEHVEDFKSVRKFKIFNTNNLWINLRALKRIMENEGMELDIIVNPKTTDDGQAVIQLETAAGDAIKHFNNAHGVNVPRSRFLPVKSCSDLLLIKSDIYSLQHGQLVINPQRMFETTPVIKLGDHFKKIAQFQKRFKKIPTIIELDHLTVTGDVYFGRNVTLRGTVIVVANEGQSIHIPDGCVLENRLLSGNLNLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLB7</accession>
    <name>A0A2G8SLB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLB7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLB7"/>
    <dbReference type="OrthoDB" id="3329at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="6">
        <location>
            <begin position="495"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="595" mass="66085" checksum="A4ABD766723BE82A" modified="2018-01-31" version="1">MREVDALDGLCSKVTDEAGIQFQILNRSKGAAVWSPRAQVDRKLYKKHMQTTLHNYPNLDIRPGSVFDLVLNQPSMSTDFPRWEVSGVTLAVKLESGEVITCSQVVICTGTFLSGEIHIGMKRFPAGRMNEAPSVGLSASLRAAGFRLGRLQTGTPARLAKDSIDFSKLVVQEGDKAPLPFSFMNDRVANADNQIVCWMTATTPTTHQIIRDNIHQCVHIQETKKGPRYCPSLEAKVTRFPHKSSHNVWLEPEGYDSDLIYPNGLSCSLPEDVQENMYRSVPGLENVKLVRPAYGVEYDHIDARELRPTLETKRIKGLFLAGQINGTTGYEEAAGQGVVAGINAGLSALRRPPLVINRAEGYIGVMIDDLIVKGAEEPYRMFTSRSEYRMTLRSDNADLRLTEKGRATGTVSDARWARFEATRAELGRVTELLQSCVLSPQKWQAYGFDRKRDGALKSAFELLHHRNVPVEALTTVLPELASVHPHILRRVETDAIYSLHLRRQAADLRVFMEDESLALDPHLDYSSVEGLSSEVRERLAKVRPTSIGAAKRMEGMTPSSMIYLLRHARRTNGIRGIGSGQVVELENGESAAPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLL1</accession>
    <name>A0A2G8SLL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA replication regulator Sld3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03418</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLL1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLL1"/>
    <dbReference type="OrthoDB" id="3003917at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013567190" description="DNA replication regulator Sld3 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="3">
        <location>
            <begin position="46"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="664" mass="72162" checksum="6339EF79F8C7C89C" modified="2018-01-31" version="1">MPLQFLVPALLRATSTSASASDPAASSSQQQQDAGPYPKDQDQDQDHPHPHPLHALLQPVLLTSRAASQKYHTRIPGVISEEGEPADPEEEYVWYAYHKDKLADGEDERQDGHDEDEDESQERLKRAWLEKYERREVQIQMLLHFLLVSLPGDRDRAAAASRAEGGTEGDIADARPLPPSLSPSQSKSKKHKRKNTDRGGRRAQDPPPPPPLEERLESYMDKLAMWQLMQAVDGSLARGATVRSATAIGKAREKEKENGKGKDDRDWMQAFCEDVVEPLFKAKLPELCALFRSKLFPDAGHSDTDSLGLSPPLSPKPAAKRLKSSASSSAAGSASASSTRAASSTSASKEAAAKGKGRDNHKDAMRARSNSLARSLEQERRERERSRSLSLGPNGLRARAILPEVTMTTKFGRARAKQKQKQKQEQAELERTASLSRTQSQSQQLGAASGQDGKRVERMGSVLVEATPTKPRDGTSKPQSQSQSQSQSQSQSQSQSQSQSQSQSQSQSQSQGSRVQSQSQSQGRLPSLFAGPSTSAWASSRLSSQTAFTRVDSLHIDTDDDDDDDDAGLVATPTKARRKLAVRQGLEERENDMEGSEWRLGNLSRTLSLGVSNSQEQPESEGDGPPISSSPGDLGGFGDAVTPPRRGAAQLGGRIMVEDTPTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLR9</accession>
    <name>A0A2G8SLR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_03296</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLR9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLR9"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL34518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="317" mass="34933" checksum="7820E9BE07E06577" modified="2018-01-31" version="1">MSTSRVWLITGTSSGFGLEMAKAALANGERVVATLRKPEVLSDFASKYTPAQLLVLRLDVSKPDEVKAAFAKAKATFGRVDVVFNNAGYAVAGELEGIPNEHARTMFDVNYWGAVHVSQEAVRFFREDNSPQGGRLIQNSAGVGLVTLPTLGFYASTKHALEGFTETLHKELNPAWNIKVKPTTLATMKERQNDTNIWLANPTQISSVLFGGFVTEFSTRSLQMLPQHPAYADDANAAAAFRKVFGAPTVESRKKLGFGDPVKGIEKVYELSKLENPPLRLLLGKDINHYFKEHIAQLTKEVDEYAAWSDNLGYENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM65</accession>
    <name>A0A2G8SM65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM65"/>
    <dbReference type="OrthoDB" id="2741929at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="76944" checksum="46AC014F92AA815B" modified="2018-01-31" version="1">MDPEKATHELDFFLNGVVRTTADLREENCRLKAQSERLEKRLSEIMPQLELLRKERVALKGAIGVLLRQSGALPGYADDEHRQPETFATLPYEILQHIFSLAIHAEPAYQFDPSVRPGAHNPWFELVRMKKAFPLICRASLWPGMLMLYSDVVLRRMGQVSAFAETLRIPDVGPRLGTFIKSIRWDSCVVAAPCSDVIREDLTSIFTRCSRLQSFSFYPHTNFPLRCTIPEDDDCEGYFNPLWFVMMSPSVPDYPLLQTTTFNLRSLDLGDLCMDEAILHAIHKLLPALNILESLILGEWPTDPPILPEDSGLMKLPAVSLPALTNLQIFATSAASDKYLCTRWEVHKLARFTILACNGWPGELLAQFGRGLRYLHLFPTQSVFSEPPTFCPTLEACSTLVEVCPVLEHLIVPLLATPYTPFINSPTLLHLDLWKARGKPMPMRRQDQSLAASYLRHATRPGNTLPSLRTVRLLFTWGPKDALSMESSGSSWSGCRSHVRNPDWPWICHPSLLPEGSDDVLYYRFPQGWVAQTVATVIPQDLGEYGWEEPLDWNWENDWPAVYVHFEELLAGMHTNKPGASVGGTDEGVEEQPEGDGVEGEDNDAGGEKSRIVASDDDEARVRDEQEKREQEEQERLEAATELDLPEYPVVQLDRATVLAAFRSSRDRESYNHINIWDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNI1</accession>
    <name>A0A2G8SNI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNI1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNI1"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="304" mass="34183" checksum="C64BA24797A28DDE" modified="2018-01-31" version="1">MSRWCTRQVFRCFKALERFGDRVTGAAGPVFVALAVGLLSLGVFCFFEIVQPTLPHKWLTTPVCAAIVLNLFGHYFFVCTVPPGFADDPHAIGNGHGHGHGNGHGNGSGRGGILWARKRRSAKYRALTGVRWSQDANVTRAAVSKCKRVYMVIATGCFIAFGWRKVLVALGWFEEPWPYFAPPMAFLLTFILSGVLCMAVTAMAGWHLFMVACGETSVESQDHEHYRRIAQQRGESFINCYDMGYLKNLQLFFNVGQDGYPYYTLLLPFRIEPYTDGRAWARRQGFEHHLGVRPGEELTDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP58</accession>
    <name>A0A2G8SP58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP58"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="258" mass="28590" checksum="648EA98350AA266B" modified="2018-01-31" version="1">MGQLNETSNDPDVLKESDMDIELVMGLLPLQEVLLYPSCPRAPPRARREGVYCARPRDRDDLVRFRGRVLERLRAPQVANYLSNDPGYPSLPTTVFQRAGRAYPDVAANPGELILFFVFVSSWRQAPDGDPRRRATHAGGPNDARIVRGKEAVGWINPACISLGPGSLPPGRIPCASSASLAAQRLRLALRPCRTEWWSTPWHALSSRAFELRHPPIWSYMCADILIWAPPELYSNQFKSVFNDVTNGSNPGGGTPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPM9</accession>
    <name>A0A2G8SPM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPM9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPM9"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27844" checksum="6146B3BCFF673AED" modified="2018-01-31" version="1">MTATYPTQQEAALVAAAEKLMVETMARYDPSHDAYHDSPRIQRRPVQRVRKTALQLARTVSVGLPEDRQPDLLTIELAALLHDVLDKKYVSAEQAADPYAYFVPFFEKAASESGLDLVEDGRARIIARIIDNVSWTTEKKRLAAGQIENWHTQCVELHCVQDADRLDAIGAFGILRCAAFSAATNRSLHVSKNDSTYDATAIGHFYDKLLHIRERLKTEPGKKLAEKRHQLMLDFLHAVDEEYDVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ84</accession>
    <name>A0A2G8SQ84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ84"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ84"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="683" mass="72396" checksum="FFA0CA0316ED66FE" modified="2018-01-31" version="1">MRSFSSEALEYQQTLEIENTWPEKLMYSIMIPHKAWAASEKVSAVVKFQPLVKGARVLHVTTTVNETVKLWARTGCQENTRVIASTKHDIVEGKAICVDEQQHRFRYPLIGNGHGHSHSHSHGHVRRYSASTTTPSTSGQPHAHHTNGNSYFPPAPMSTLSRSESPSHTPIELPPLTTTTTRSSSSSGGGAHSSTSSSPDASAEPSASSSSVDLPPQAGPSSQPLEDTEVSTDVVTTLNITVPLAATPSHSLEPIQVSHRVRWSILIANLDGHTSELRCSLPIHVLDARLAEEARVATLATRRLLLGAADVEGGEAVIGSGDEREEEAESLPSYPAHVRDRVANAYLPDAATMRVANAWVVNGISPVIPPSTSETSSGGGSPAAFAYETWQVGPGHSGERPPPRSEHLPHEPSAGGAAPLEWVNTELLLSLGREAPEAPIFQNHGNHHGQTQSQRATPPSRTPPEQQHQQQHQQSARPSRHGSRFASRANSRTASPERSRSSTELSDAARGEGGSETFVHGHSTASRNVHGLFQIAMRPFTSLTSTFSRSASHANLAALAGTPPSGAQTPREDGINGGAVVMTTQEMLHHAFTQVPDYDMASRGFLGGGIIPLSSLRDLPTYESVVGANAERRGSLGAGERSFSDGDLAGMFAAHRLGPRAGRSALGRAPPASGVAPAAVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQJ1</accession>
    <name>A0A2G8SQJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peroxidase</fullName>
            <ecNumber evidence="15">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_01697</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12 15">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="12">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="15"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQJ1"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00692">
        <property type="entry name" value="ligninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 12" id="KW-0349">Heme</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="4 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013430232" description="Peroxidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="65"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="37"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="279"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL36037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="366" mass="38601" checksum="C4C18D8FCED83FBA" modified="2018-01-31" version="1">MFSKIIVAFTSLAVVVSAVPMRRATCSNGRTATDAACCVWFDVLDDIQQNLFDNSECGEDAHESLRLTFHDAIGFSPNLTAQGKFGGGGADGSIMAFAQIETNFHANIGVDEIVETQRPFALKHNVSFGDFIQFAGAVGVSNCAGGPRLQFLAGRSNISQPSPDLLVPEPSDLTDTILARMGDAGFSPNEIVDLLASHTVAAQDKVDPTIPFRKGTPFDSTPSSFDSQFFIEASDCRTLLQGTLFPGNGSNVGEVESPLLGEFRLFSDNELARDPRTACEWQSFILDHDSMVSKFEAVMAKLATLGQNPAELTDCSEVIPVPASVQLPAPTLPAGKSLADVQAACAATPFPALSAAPGPATSVAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS96</accession>
    <name>A0A2G8SS96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS96"/>
    <dbReference type="OrthoDB" id="2762075at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="224" mass="24693" checksum="EACE8B842C18725F" modified="2018-01-31" version="1">MSCTTSSALCKSGTTTVLRPGAEARTPFGTPFFTLVIDPKTDTGTFVKRPLDSRMWEEIRAWEKLQRTGKLPENREYAAVLQETRFTDDDNDGDNEAVVDAPTSKWAVGGGFVVGGEGYPSYFVPDVDGPGDDDSEATTATTLAEGDGDNEEYDDRLWPDTYSIGSDSDIDYILDGFVVIDMADATGSVFWNQPRRCRRKAVQGRGSLWSRFLRRLRPASGATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSC2</accession>
    <name>A0A2G8SSC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Part of a larger complex that includes HSP70, HSP90, and immunophilins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSC2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSC2"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000004">
        <property type="entry name" value="Putative stress-induced-phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000020">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000027">
        <property type="entry name" value="stress-induced-phosphoprotein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="136"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="8">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL36681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="586" mass="64955" checksum="1AF52833C1F52E8D" modified="2018-01-31" version="1">MADALKDQGNKAFQAKNYDKAIDLFSQALELDPGNFVLWSNRSAAKAGKRQWAGALEDAEQCIKVNSTWSKGYARKGAALHGLRRYPEAIEAYETGLKIEDSPVLRKGLKEVVDAKEADERGDGAEAFGLGKMFSDPGLFAKLAANPRTAKHLSDPTFVQRLQLFQQNPKLAENALQDPRMIDVLGALMGIDMQGFAREEGSDELPPGVSRSDAQSRSRSPPPAATSPPPQPAASSSKAPEPAKEDVEMVDEEEAAAKKQAEEEKKLGAEAYKTRDFEKAIAHFQKAWDVYPKDITFLTNLAAANFEKGDFDETIKICEKAIDEGREIRADFKLIAKAYGRIGTAYQRKGDTSTAIKFFQKSLTEHRTPDILNKLRAAEREQAEKARLDYISPEKAAVAREEGNTFFKAGDFAGAVKAYTEAIKRDPGDPRGYNNRANAYTKLAALPEALKDAEEAIKVDPKFVKAYIRKSHVLYTMRDYTKAIEAVQQATDVDEEKKHAKEIQDQVIKCQQAMFSQREGESEEETLQRAMRDPEVARIMGDPIMQSILQQAQSNPAALEDHMKNPTVRQNIIKLINAGIIKTGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSE1</accession>
    <name>A0A2G8SSE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="10" type="ORF">GSI_00384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSE1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSE1"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000054">
        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03053">
        <property type="entry name" value="CTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032442">
        <property type="entry name" value="CTU1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000541">
        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="8">
        <location>
            <begin position="54"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cytoplasmic tRNA 2-thiolation protein 1 C-terminal" evidence="9">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004976-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL36695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="355" mass="39761" checksum="B841B2A2B873F1EF" modified="2018-01-31" version="1">MPPRTCALCNDARAILKRPKTGQQICKECFFYVFETEVHNTITEANLFKSGDRVAIGASGGKDSTVLAHVMKTLNERYSYGLELFLLSIDEGITGYRDDSLETVKRNQQQYDMPLKILSYDELYGWTMDAIVAQIGKKNNCTFCGVFRRQALDRGAAILNVDHIVTGHNADDIAETVLMNIMRGDIARLGRCTSICTQGEDTIRRSKPFKYAYEKEIVMYAYFKKLDYFSTECIYSPDAYRGHARAFLKDLEAARPSAIIDIIHSGEAFEVREDVKATQKSQQTCKRCGYMSSNELCKACTLLEGLERGMATAAVTDRARQKLDADGPSPGNLRTIPFFQLPASLQNPTTVETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSX2</accession>
    <name>A0A2G8SSX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_00571</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSX2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSX2"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="204"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL36881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="379" mass="40249" checksum="02F79A9F12380A5D" modified="2018-01-31" version="1">MSDTAGKPITCKAAVCWGAGEPLKIEEVEVAPPRAHEVRIHILWTGICHTDEYTRSGKDPEGLFPVILGHEGGGIVESVGEGVTSVSVGDHVIPLYTAECRECKFCKSGKTNLCGSVRATQGQGLMPDKSSRFTVKGQPVHHFMGTSTFSQYTVVADVSVVAVNPKAPLDRVCLLGCGITTAWGAVVKQPGIKGSTVAVFGCGAIGLGVIATSALVGASRIIAIDMNPGKESWARKFGAHEFVNPTTLAEGKRIQDHLVDITDGGLDYTFDATGNVHVMRAALEACHKGWGISTVIGVAAAGQEISTRPFQLVTGRTWRGTAFGGVKGRTELPGLVEDYLQGKVKVDEYVTHHRTLAEINEGFHDMHGGDCIRCVVDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSZ8</accession>
    <name>A0A2G8SSZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_00580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSZ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSZ8"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="63"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="253"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="831"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="898" mass="101330" checksum="76A659201CE148C7" modified="2018-01-31" version="1">MSSWNSAYPPHPPPTRGRSRSRSPFRGDTYPPRPPYPDQYPQDPYRTDWEAYDRDRAWASYERERQAYDYSRRGRSRSPAPGDEAGRKRRRSLSPWERSRYEPRPRYNDDYDAHSRGGYGYERGPYPPPPYQSGRRGPPDPHTFDYPATLKQYAEWFRYYYPQQAMEEDNADKAAEQEAGDGSKPRNGIRSRWEKYKKEFAAQQLQRMFDHHRKSPWFAEKYDPAPEFQAMRTRVRKLGWKGRMDTFIVDLESGTFDPDLSEPVPESTRENANGDSSTTNGAGADASVDDIKPSGDDDMQFNVEPEEDAGGDDATRSGSNKNKGGANRGEEVAVPPEGNQVMIRTIPPDIGRAKLEEFVSKIPGFVYLALGDPLQKRNYYRAGWMKFTEEADMPSVMTELSEKKIEGFKLHVAHITKPFVTRTRHTPDVASKPDRLVKDLENAKRLAAILEEEYMALRKARIDMKQNGDSSADANGETEVPNEDATMGDAVDADDDPEPREMGSETVERHIEKVMADLQEQGAVDTSDEKALEAKRTVIALDLYLAYLRAAFNTCYYCAVITDHVEELQRKCVKHLRKPMSKMLLQEVQAAEASKADKEPKVEEGVEVVKERDALTAKEKENRDWKRNDERWLEWLDSKVALLIDRSGVDPRDYGGKSYEEELSRACEPYIKQEDEGKFRCKTCQKLFKATSFVEKHIANKHPDLVKGLDEIPYFNNFALDPHRIQPFTHPPQTMGSSQPPPPQAYGLQASAAYPPPAAYDARPPPYNPYAVGGYPPYPPGPNYWDPYAYPYGAAAYPPPPPRRDEGVVPRRLSDRISGIALDQPLETLPVPASAGLPAKPAVSLEPGPGVRRGRGGAGGPSPPPPPDAKEDPRAQAGKKVSYVDVDRVAEGDVELEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST74</accession>
    <name>A0A2G8ST74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST74"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST74"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="139"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="894"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="920" mass="101624" checksum="818864766E807CA2" modified="2018-01-31" version="1">MYSSHSPSQSNTSLSEDEEDDFNHKSAFYRDTDSDTALITPAQWCSRRGSLPLKTPPSQADRLPPEILIHILRHLHSSRDLYHALLVSRAWCECSVELLWYRPSFSKLHTLVKMMRVLSRDDSTFVYAQFIRRLNFLCIGNDLTDTLFSRLAQCVRLERLTLINCTSLSDEGLMRVLPHCPSLVALDLTGVSEVRDKSIVALASSAKRLQGINLTGCKKLTDKSVFALATNCPLLRRVKLSNVEHVTDPSISALARSCPLLLEIDLNNCKNITNTAVRDLWTHSVQMREMRLSHCVELTDAAFPASPKRDIFPPTSNPFPSAPFPANELPPLRVLQQFEQLRMLDLTACSQITDEAIEGIVSVAPKIRNLVLAKCSQLTDSAVESICKLGKGLHYLHLGHAQAITDRSINSLVRSCTRLRYIDLANCLQLTDMSVFELSTLQKLRRIGLVRVNNLTDQAIQALGERHATLERIHLSYCDQISVMAIHFLLQKLPKLTHLSLTGIPAFRRAELQQFCRPPPSDFNTTQRAAFCVYSGKGVAELREFLADLFASITNELATSNDTDYDDDFEDEAHDRYHSSRSRDPDPDILDDDDDDDDDVGSDEAAPPENGDLQNTPRLPERMPITPEESSNRTFYPPISRELMMTREIRRNPTPRAQPRAQPANAPPWLNTAITRTRRGFGQQPIVEQSTSPTPSEAASNRSAGTNHSTGTAFFRTYADHPPGSARNGVMTPDLVYAEIGHGRGSGPGPSTILVQGHTRREPVIESSYPSASSSPTRHATTLPSHSSIGMAATEVFSAPQRILRLHEHDPRIEIIQDHGPVLHDASNSYLRPDGAIGFSVLREASPPSPTTRELQESVHSALAGTPLLEGDARGRSVKRTLRSTFAAAETFFTGRGSGGNAPDGAAGLAGGRDADPHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST76</accession>
    <name>A0A2G8ST76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST76"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST76"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="590" mass="62944" checksum="29EEA16A6364F24B" modified="2018-01-31" version="1">MSNPSDTQAAAPNTVQTIPQTTTDPTDLVLLIFIHGFKGTDSTFGEFPQRLQHILSESIDNTVVESVVFPAYETKGELNAAVVRFADWLTDLTVKREVANGGAGKAKVVLCGHSMGGLLAADALLEFVRTRPDKRAPLWPKIVACIAYDTPYLGLHPGVVKNGTNQAAQYARTAQNVLNSFRTWRSKTPSGAAAAAAGGAAAGAAVIAVGPAPIDTNTSPDPDTSKDGDETPKSPTTKTPTGESSEGTTVTSLWQKWAAPAALAIGGVVLAGTAAGTAYYKREEIGVGYTWVTDHLKYIGNLWSKEELEERLDRLLTLESRMGVLFHTFFTDIPASPPAYPSNRTFIVLPHRNSPLATHFMPNRNTLASDEIQAHTGMFDTKTNDGYYQLGLVTAKLIREAVFRARRVEADAQTPKSLPSALAQPRAPLQQPSTVKPAAQESVASPAPPASTAAVSPPAVAGGVAAAATTVAAASAASVAASASAPRPPAADDEDEEDDDDDDEDEEEEEEEEEHIPVMEKPHIMAEKVDATQAASAPKADEEAEDEEDDEEDDEDEDDDEEEDEDDEDEDEEDEDEDEEEGVQAQPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STS1</accession>
    <name>A0A2G8STS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STS1"/>
    <dbReference type="STRING" id="1077348.A0A2G8STS1"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25252" checksum="C396EC348111263C" modified="2018-01-31" version="1">MSAFFGLGKTRTFKPRKDVPEGTKQYQLRKYAEATLGSGNLRLAVRLPDGEDLNEWLAVHAVDFFNHLNMLYGTVTEFCTPQECPIMSAGPRYEYLWEDGVRYKKATKLPAPEYVDALMNWAQGLLDNEETFPSEMGKPFAKNFRETIGRLFRRLFRVYAHLYSNHFDHICALGIEAHLNTSYRHFFLFVNEFDLVDKRELAPLDELNEAILAEDKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU86</accession>
    <name>A0A2G8SU86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU86"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU86"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="103"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="527" mass="57400" checksum="1447EB0963682D2D" modified="2018-01-31" version="1">MLRRAWKPLLGTTVLAGTPAYIYYRYYNKPTLQTFDVSVRETGPDGKRQMVTRAIPLLTKEQVDTRLREHATSKSTTRPGGIVWKSTTSYFSSNDPIEDANGNLLIERDASDNSPPGDYLFYAVMDGHAGYHTSRVLADILIPTVAMELASRINDPKANLHDTGLLQKAKSLIWSSASTPYDANPSNVARAIQDAFTKLDAQIVNAPLEILYHAVDQDALKKKVIPDLSGHPLATSSIQTAQSGDSRAVAGVYEETSDGQGIWRVEVLTEDQTGRNPNELKRMQSEHPADEALDVIRNGRVLGGLEPTRAFGDSRYKWPREVQEVLSKAFMEPQGKSLHSTPAKLKTPPYVRATPVVTHRPLSFLPLPADGTPAPKAALRFVVLATDGLWDELSNEEVVALVGGHLSGLRGTVSKAALPGLVRTATGAAGVDGKDKVGRGRKAEVEPEGAWAFEDDNLSAHLIRNALGGGDVEHLCKLASIPAPWSRRFRDDITVTVVWWEDGQESQAQVEKVAIPGTEGQQAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV45</accession>
    <name>A0A2G8SV45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01335</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV45"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV45"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="386" mass="42988" checksum="76E44EEEE4CB3E11" modified="2018-01-31" version="1">MFTPAPEPPTRLGYYRQLAPRAGIHVSPLCLGGMSIGDKWDKFGMGSMDKDASFRLLDAYFDAGGNFIDTANSYQDGTSEEFIGEWAEARGFRDQLVLATKYGNNNCRGNDSIVQKVNFGGDNLKSLMLSVETSLKRLRTTYIDILYVHLWDSITDVEEIMDGLHNLVVAGKVLYLGVSNWPAWLVVKANDYARQHGKTPFVIYQAHWSVLDRRIEHEVLPMCRHEGLAIAAYGVLGAGHIRTDAEEERRRETGEHGRTSFGLKWERTPEERAVCRVLERIAGEEEVGVGEGNLGAVAIAYVMQKAPYVFPLVGGRKVEHLAANIDALNVRLTDEHMKAIEDAKPFEKAWHAQIIGDYGEVPYLLGSQAKIVPQPLLPPIKPQPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV57</accession>
    <name>A0A2G8SV57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_01350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV57"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV57"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF867">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="7">
        <location>
            <begin position="28"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="6">
        <location>
            <begin position="190"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41413" checksum="8D51A5F8AC75B07C" modified="2018-01-31" version="1">MTETATYPEVPHHPPPPPTTEDLDWADLPIIDISKANTAGGRAELANEVRDAMRTFGFMYVVNHGWTQAQNARIFDIADVPFSQVSEEEKRQFSNEIKNTGSWRGYKPRQFWTVDNGVPDQIEQYQFFEQKHHPQALQPFLPEIYAFAQHNHFKVLHPILRLLALGMELPEDTFVEIHDGDATGPSFVRFIKYYPRSEEDEAKTKNVWLKGHTDFGTITILWSQPISALQIMTPDGQWRWVRHIDNALVINIGDAMEMLSGGFYKATIHRVVQPPPDQRAHARRGAFYFASANDDVRLVPFLDSPVLQREGVRRRIEDGDAPTMAEWRAALVRTYGVAELRRRDDVVEEQVVGGIVVRHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLE8</accession>
    <name>A0A2G8RLE8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_15035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLE8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLE8"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="395"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL22347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="790" mass="88722" checksum="922E6616797EAAAE" modified="2018-01-31" version="1">MLRIPQLLRATCHHDLRTPTVNIQQTLLRTHKFKAKPRQKPVRLHSPSRRVVQEEETGFRLPADQVPDYFSRNVHTWVSQYSQRISDRLTRFGIPKDDLRPLLRLYAISMANGDVFRDLAYGNDQLARISRDMTSNSAQAMDRYFTRMLYEWTSLPEGQQALESAVSSDVVSHMQSLFRAADLSSAGWEYSSARGSPPRKFIMHVGPTNSGKTHNALRALAASKRGVYAGPLRLLAFEIFDRLNKGQIIPLGMEADPQAEPDANSGIDMGDGADKGKAVIVKDGNPRFARECNMVTGEEHKIVSPSAPLLSCTVEMTPLGTRWDVAVVDEIQLIADRQRGGAWTAAVLGLNAKEIHLCGEESAVPLIEAMVKQMGDSIEVHRYNRLTPLVVANESLNGDLSRVRKGDCVVTFSRTGLFGLKQNIEAAAKMRCALAYGRLPPEIRSEQAALFNDPDSDFKVLVGSDAVGMGLNLKIKRVIFETVSKFEGRALRPLSASQIKQIAGRAGRFGLHGSDTTGVVTTLRREDLDFVRQALGTSFEPLNAARLNMNYESYRKIHEVLPWGSSNMTIAEVYHYVSRMSPLFEFQSILELEQSFEFIDEFADCLTLRIRLLTSNSPCPWRDASAVDGARSMMEIFRDKLRVPIEDALHRAQLLNKLNAALVLMESSGGPVPEQKAIVRLLGELETVHKVIVLYLWFSYRHQVAFPEQEKGFHLKHLTELAMDWCLELLHQMRMKTKNPAPHARREVLDRRPMKKPDVRLAEASASLDRESIDAVLEGDDGHFIRHIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLV6</accession>
    <name>A0A2G8RLV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLV6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLV6"/>
    <dbReference type="OrthoDB" id="5429442at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="945"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1024"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1047" mass="117312" checksum="6874DF1686A8CE74" modified="2018-01-31" version="1">MCSDENGAPHAARYLNAQLAVLHENAQKCLEEHDQARTVENKHFYALAEFTVHKPGHIDSAFHAMFGKPELEFVCNHDVIIHLHLKTSHLTLDASRPGRSGQHVKLPSDLVVSYRLAFETRRIIGNDVKIGSHGSAISLVILDFKKPTFVSAEPEVTVGRDILIRYLNEYLDLLHAAGHHVLFSLPQFGDQGGMPMVIDHSLMSTSQLWIGDIHGITVNQINAYLTSIWLKSAMLAQHDVKAGIDWRTRCLAEFSSSSHGARSYGRFKVKFGPPRVEILCAKEVVIYFNIEELDLFKSDDFTAAPERSYKGWRVAMIVNVLYSKECEGQVVDIKLDLSHSRYHHFLSEFPGYDDTDEFAEESWRLLIGFFAEEYLQILESMRYHIVYSRDTRWEVISNHPSSAHEDLDGSWWSLELTDKSGDCSRQTIQHTKMFGFDQVVAISQGSLNAQFATLCTAAQSILHRWHYKEFFSATFRPLSVRLLSNNRAIVWVHLHGGHLKTLKDLAPWEGSTKHDFADWRLAFEVELKMCSHDKFEGASSEVFKKAPAVHMHAGQADRDLRHIFLNLRKCEFLHDYSTFGDLTNGGDNRASILKLQAVVHYITKHYFHAICKDGLNVISSIPVWKTGKSLPSYALTDVAFHVYSKVEITRHNWTHVTPGMEPIVVVIGTTGFHKLPSKHLDFSTGWVVQGNKGFSHGTISISKRVFIEERLLHLLSRINSLTTLIPSTPEMLQGFQGLSLKSWAEHELRKDRPSKWELQPSDGDGYLKYLWEHSEEWVYKLRGNSNMMSGTQGISCVTRNYVELPTTVKQGAMHIKISGSVTLKLTQQTTELYTAEASVNWSTNVTVQTIGSGIKVNTLGSHDPTFSGAHFSTGAAAKFRNPMDMLKEAFPCKIDLDELVQEISAFEGTWQYYFPLMNTYSLASPVFNDDGDLLFELRRHGPSASRMPTAAGSVLGSVNSSSRPRSPALWSRSVSGRSRISLASTISTNGNGQHTVPVNVQAPVPTAHIQLETAEVISVVNGKSTTRKASNGSTLPTKVEDGVARAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMP0</accession>
    <name>A0A2G8RMP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15267</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMP0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMP0"/>
    <dbReference type="OrthoDB" id="3251181at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="563" mass="61021" checksum="4D6810EEBFCCB579" modified="2018-01-31" version="1">MSTEASINSSKYSVPRLATDGSNWVTYQARMQAIQAAKGHMPHIRGTARKPPLPPPLERANPHISGSTAMTTSATATTTTPSSSPKTTPAATTTTKPPSDVYSHLTDDEYTELVEKMDAKYCTWEAKEADARALIYETLGDDLFIEVQSQPTAKHLWEAVVASCENKSLMYANAICTRIQNLRCPESGDVRAHLALLLRERQNLAAVGSCLGEDEFAAIITNSLPESYHPRIQSILDISSLSGHTIPIDFLIGKLNEEYDRRRINKANGSALAAAAAARSNAGSGGRVPVECYNCHRFGHIARNCREKGGGREGQWPKPRDNNSGNGSANANAATEKGFLALGNTVTSALVAAPGSYVDVFDSGASVHILPYRERFTSFRELQPARSITAANGEQFLATGEGEVELRVPNGDKTQLLKLRNVLYSPSVAFALVSIKKADEGGYTTIFEHGECRIVERASDLDVARVPLTDGLYQVVSRYIEVAAAVVSSTRPGSNRRTLEITQAEFHRCLVHYSYKAARSLILNGHATGVEFTDPAPYDAQCDITCGFHCCITLDHYSGPLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNA9</accession>
    <name>A0A2G8RNA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL22991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNA9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNA9"/>
    <dbReference type="OrthoDB" id="2734749at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="86" mass="9608" checksum="71B47741168991D6" modified="2018-01-31" version="1">MRARYLGPYLVVSRNRGGAYILSELDGAVFDRPIAAFRVLPYLARREPIAFQPNILDTDSRRIRELEASTDKGDGIADAELADANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNQ7</accession>
    <name>A0A2G8RNQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_14463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNQ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNQ7"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="128"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL23154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="408" mass="43891" checksum="BF684F29EDB3F336" modified="2018-01-31" version="1">MGAQISSVPRDPFNPNRFLSADAPALDKQVRFDEHQPASANPVVDSTIHRSQTAGSSRSTSTGSLPRQSRWPPSSPPWRRAVSFILALVGVAALLSAFTSYHGESLATRLFGKYARPSLLYTVFPLSFGAPSDPRTTVADNFLARALPIGRYDYALSANGGKIFLPLTTPFDDNPSSPASLSIDSILTDDARLDGSFSSPGAQFQVGISFATTIYPTHFTIDHAFSPDKIGSSNAPRHIVFWGVVEGVGNKGRVSRVVGDLGLSDVFNRTAPNLHQRENFLPLATAEYDVRGSCHVQTFAVHPGLVESNIDFGVVVLEVLDNWGGEVTQLYRVRVHDAGPSTTAALEETAFNPPPSPSAPVHGVRRSLDLNERNIKGCKAARTKLRIGAEETCESPPYHTEANGPCNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ23</accession>
    <name>A0A2G8RQ23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14922</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RQ23"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1353"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="918"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1287"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1497"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1656"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="399"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="869"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1110"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1295"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1506"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1518"/>
            <end position="1541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1691" mass="182466" checksum="49DFE9483E4DABC2" modified="2018-01-31" version="1">MATFSDGGDVAAMADHDPTGNMRLYLQSLLDNKEKQLQSAATLGHQLLAQRVELEERIKQMQELELDSSGSDDGLDVSVRDKYRELADAITAWDTENEQLTSVFGSKPTNGVHAPSSRHPEPSRNEHERSKGAAAGPSAAQSSRRAKNAAHRADDVEFAFEIGSGLLTEVRRLQSLLGERDKVIQDMKEEKDDLDKTLENLRQALRQQEQSADKFKEENWNLEVTLQELRTQVADSQATAQRLEGENKRLTRVLTTTRETADQHKNEADRQQVAFEELKAKHETDVAQARKHAASLQRDKSDLQQALDSMKAEMTKASRRLPRFGSPLTPNGPSAASEAATPADHDEDDVFSNAGASTHTRKKLDNSGLFPPDGFDFDESPDPSPSKPFLAPNHPTNEIEALQQRLAHAQRQITTLKSTLQREKELRMDYRRKLDASPGFAIEEEDDGIIVEDADPVPKPKARLTPYRSGRGRGRGRGRGGLTLIQRLGMAAHSPSSDYNDDQDFDTSPAPSVPPIPAEFRQDAGLGEEDEDEEPDFQASPSPAVISNRTSVDGMDPAFANILRRSASAGSMQNGSPLRQSVLARMARGGTLPRRSRGGAAYQEARPPSLVGAPEALAAEFGFGVMEPDATSSIADDLQDELVAVETVEFGVQTDFEEPLPPPPVIQIIAASSSEMGIQVDPEPLPVVLTSEISLQTEPEIVPVRADAEIQAEAVPVRPASTFASAETQTAVPVVAHAEMQTTPAPARAEMDVQTQPVFTPAAAIAAAYTGVQAADLSRSSSGDTTVHLHRPPSLTLDEEAMFDGDDDVTETGSIMAETTRTEDFTDAHSVLETPTTTESMSDYHSIRTVSESGYSDSESDDESIKASRIQSRNGNVSAMSSAVDIPQESPSPVAPVSPVKPPPTYATVEIATDPILEPPPVETAEEGIQVEPEPEPEPEPEPKPVLVTVGIQAVPEPEPEPGPVVAPVIPPPAPEPEPKPETKEISIQTDEWVPPAPVPVPATIPSAIPSRTSSLTSAIVPVSIPVPSASVASAAGPIAGAATAATVALVSTAASVGATTAPAIPALFRVGPSSQQFQFIPPSSTGPTPTPATSSPSSVPVSLATPSPNTTIRDPNTTIRDVNATFTARPRTSHSDRRQSIESTLSSVVDELGSRSRTASVLPSVDKSRPPMMVLPPPPRQPPPPNSMLPPPFIPEKRMSYDLPPPRPSSPPPPELIQRATTPSLGIPGRGTIGRAHGSSMPPSQQGLRQLPSTSSFRSAANAAARAPLASPSALSFNLRDRERRELSSASLNSGGQSIGSQRSSISSDQQYEAHMRRTSNVEATVQERAGLAMGNGGPMSTDPAIIHAITQTMIGEFLYKYTRRAIGKGHGERRHKRFFWVHPYTRTLYWSSADPGSSNVTESSAKSAYIESVRAVMDPNPLPPGIHQYSVIVSTPQREMKFTAPTKERHDIWFNALKYLLTRPGNAQMGLPSQGGAGPMSPMTRNRELPEEYAANVMSSPESQRSRRTDRSRDSWNNTPRGQRSRSQISLGGSLSKRSGTPAAEYLRWAEAPSSPTKEYEHIPGGQDEEELDFELHDDTLSDEGFEGLENVRACCDGRHTVGRSGRIEHHHHHHHDHPNAPLIQKRASSRSRDQLLDPNVVDIQRPVSPAWSFRSRAGSSTSNDGGFFARFGTRRSARTVASAAGQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRA9</accession>
    <name>A0A2G8RRA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber evidence="4 12">2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALG13</name>
        <name evidence="15" type="ORF">GSI_13806</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141" evidence="4 12"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRA9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRA9"/>
    <dbReference type="OrthoDB" id="20273at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039042">
        <property type="entry name" value="Alg13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12867:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLDIPHOSPHODOLICHOL N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="14">
        <location>
            <begin position="27"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL24055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="22947" checksum="BFF11857B33BC6BD" modified="2018-01-31" version="1">MSESLDSSPATTESARSTPSTPADRMHVFVTVGSTRFDALVQRVLSEPVLDVLRAKGYRTLDVQCGDSEFDASSLLSRNADDHWEGAGELETSVWRFKPTLKEDYERADLIISHAGSGTIIDVLRLRKALIVIPNETLMDNHQAELSDALVGLGHLKSSSVADLPRAIENLDASTLVPFPQFDGSRFRELLDEEMGFSHSRESSSGAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRF4</accession>
    <name>A0A2G8RRF4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRF4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRF4"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013930145" description="1-phosphatidylinositol 4-kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="786"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120130" checksum="1A1FE41856D60CD7" modified="2018-01-31" version="1">MSHALLLRLFLSPSFFSVHVALQYLRIYADNIGITYYLTRRLKELNPQELREVWGFVCHLVVTRPTQSKALESFVVEICHKSTHIAMLTLWYMQAFLKDLSAQHSSNASFLICQRILHECHEIIFGDLPSVPYLSLCPPASIGPSRKKVRPHVSPSMVGIGMVLAGVPGMPQLTEIMGPVAIEQGRVDELGQDIKSIERGEDDGSVVRSLSISSTADSGGDVEDDDSMDSPVPNAEQHSRETTGSGSSSQPASAIPKRMSRRQTVGAQTSPALPLRLRETRKPRLSEDPFGQEDSPPARSATVTTPFQSTPSFSSRHAYRPNSLPTADLLLQKYDFASQMHLLRGHFSRSEVQFILALENICNKLLVVPKPARVSALRAELTGLNHMLPAEICMPMWCSSSDEPQPSSHDVPEPHHRIVRIPPGESVVLNSAERAPYLLLIEILHSDLDFDPAKRGNKEILKKIVMKENEWKGTSKDLVNFAFNGSTKSKPKPIIIVPDHVTGSEAALGDEGGDTGEDTSLPQSASSSSVLSPSEPPEEEEIDLVEQLYGNESSLKANNLDLSDSIVLPPAPKNKELDMVAWSRASTNPHTPQVDKPDPFSTPNLTITPATRPSRSPPTSDPSTPARQTSQGPSPQRVISLDEYSERMRTAAVMLAQLNANLGPSAIPGTPAPPSDSSLIGTPLRWLPGTSWLSGSSANGNGYPTTPGGVGSDPMTPAPMRMRLQASEAAAIRDRIMEEMLALEEERMARMRENGVNEGSLRITPANGDMKTAEDEGIIRRELSKVDPSAVVFSESWAAKKARVRQASPYGHLANWDCVSVIVKTGGDLRQEQLAVQLIQEFEKIWKDENCQCWVRYFRILITGNSSGLVETITDAVSIHSIKKAEYARRLAEGRLGHVTLLDHFKTTYGDPSSAKFVRAQRNFAKSLAGYSLVTYLLQIKDRHNGNILLDRDGHLIHIDFGFMLSNSPGNIGFEAAPFKLPLEYIEVLGGLDSPAFREFRKLFREGFNACRKHCDRIVTLVELMQKDSTLPCFAAFGEQTASQLRDRFQQGLTQAAVEEHVQRLIDTSLGSNWTRLYDSYQYYSQSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS59</accession>
    <name>A0A2G8RS59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_13921</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS59"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS59"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="292"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="756"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL24168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="786" mass="85440" checksum="529F5C4268EDBB12" modified="2018-01-31" version="1">MSQTPYQPVFTNTNPYANQPDPIRDTQYYTPETEHLQLHDDLPPGAAVPRFMGVASHHEHRASFASSNPTLTGDDYNSSTIGLNDRGKQGFYSYNYNDSDLNASQPHLPKESYAIPQDRPYAPKPSSRKKAIIIGSLVALAVIAGAVVAVYFAVIKPKQNKNATSNNSSTGSNNNNSSSTSSGNNQNLVVQTGGAGSIVTMDDGTTFTYNNTFGGFWYYDPSNPFSSSARAQSWTPALNETFKFGEDPIRGVNLGGWLVTEPFIVPALYEKYVNTSQTAYDEWDLSIDMAADTANGGLQQLENHYKTFITEQDFAQIAAAGLNFVRIPIPYWAIETRQNEPFLAKTSWTYFLKAVAWARKYGLRINLDLHALPGSQNGWNHSGRLGTINVLYGPMGINNAERSLDYIRIISEFISQPEYRDVIVMFGITNEPFGPTIGQDAIQRYYVKAYDVVRTASGTGEGNGPWVVMHDAFLGLTNWAGFLPNADRLQLDIHQYICFGGQSADDYAARVQSGQACSTWASGQNASMTAFGMTHVGEFSLAINDCGQWVNGVNLGARYDGTFTASHFDKTGDCGPYLNYPAYTDAEKAAMQQFALQSMSALQNWFFWTWKIGASSVTGLVTAPAWSYQLGLEQGWMPTDPRLSNGVCENTAPFNPPLQAWQTGGAGAGQIPQSSLDALAWPPATLTNEAVLSTLPQYTQTGSLITLPGPSVTSVKGASFSTGNGWENPTDTAQMFVPVASCGYLDPWMGPTASPAACPPLSRRKREAAPAAFPAPTTPPSPSRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTG1</accession>
    <name>A0A2G8RTG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">GSI_12682</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTG1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTG1"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="569"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="755"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="759"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PIL24796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="775" mass="84951" checksum="9954669ACA5E0006" modified="2018-01-31" version="1">MPLAYSLPSNLSPATVTNTSSLLRIISLALISGAAIASRLFAVINFESIIHEFDPWFNYRATRVLAEKGFYAFWNWFDHTAWYPLGRVVGGTIYPGLMATSGVIYNVLHALNLPVDIRNICVLLAPGFSALTAWSTYMFTKEMKDESAGLLAAAFIGIAPGYISRSVAGSYDNEAIAIFLLMFTFYSWIKALKTGSAFFGTLTALFYFYMVAAWGGYAFITNMIPLHALTLILMGRFSSRLYVAYSSWYAIGTLASMQVPFVGFQPVRTSEHMAALGVFGLLQIVAFAELVRAHVSSKQFQSILFGSVIGIGLLGALAFGGLTYKGWIAPWTGRFYSLWDTGYAKKYIPIIASVSEHQPTAWPSFFMDLQFLIFLFPAGVVLCFRELRDEHVFVIIYAVVASYFAGVMVRLMLTLTPVVCVAAAVAFSSLLDTYIDPVEPEASDAAASPAEGTSAAGAAAAASDAGSSKKAKKAAAPDPGVASGILAAVAPSGSGPKSRGIFGLDTRGLVVFNALGMLLFFVLHCTYVTSSAYSSPSVVLASTNPDGSQHIIDDFREAYYWLRQNTPEDAVVMSWWDYGYQIAGMADRPTLVDNNTWNNTHIATVGKAMSSSEEVAYPILRKHDVDYVLVIFGGLIGYSGDDINKFLWMVRIAQGVWPEEIQEPNYFTPKGEYRIDDAAPATMKNSLMYKMSYYRFAELFGGNQAVDRVRGQQVPKTGPTLDYLDEAFTSENWIVRIYQVKKEDPLGRDLKAANAFANGKKRKKSKPLSRRRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTY0</accession>
    <name>A0A2G8RTY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_12859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTY0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTY0"/>
    <dbReference type="OrthoDB" id="5836119at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007811">
        <property type="entry name" value="RPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13408:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05132">
        <property type="entry name" value="RNA_pol_Rpc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL24972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="48691" checksum="F9E4FC3909D53CDF" modified="2018-01-31" version="1">MSQQPSGSGTPGSGSSTPGKAIASLAKKQNDITRLGAQKLKFVPTLPPRRVKEEPKKDEPPASSSADRGRGRGADRGRGRGRGRGGAEGAGRGAAPRPPAVEMTASGPFAMGPALAGTSARRTAPRSNFAPVAPPGGSGSAKLGAGLTQTTAPSLKKKEREREAEAARVKKEEEEEEAYSDPDEGVEIVDMENVRQMDWMAPESLRKERETGKNKGKGKVKKEGVNVEQTGTREAMDVDREGTPEEEVNIANAVDLSESESEEELEDIIDDFALAQEQEEDANVRQERLYFFQFPEPFPVFQSRHTQQAPDKGKGRAEPGAGEDSTKKVTFAEDTKPPAAGAAGANGQAAADKDKAEESPTVDGVMGQLEIYESGTVKMRMRNGIVMDVTAATQPSFLQHAVHLDSTNKRLSVLGEVNRRFVVTPDLDALLTAMELADNPPPSFELGEGLLTMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU30</accession>
    <name>A0A2G8RU30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_12909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU30"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU30"/>
    <dbReference type="OrthoDB" id="3365060at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="10">
        <location>
            <begin position="206"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL25021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="409" mass="43314" checksum="769D6FF6E5B9F313" modified="2018-01-31" version="1">MFPSSSTFPTTSTGTGQEQRQQFPHSHSHPVQYNGSPFNVAGMSNLNQSTASPSVRGGSLGMSMGSSLGMGSPLSESLSQSRSHYQSGYLMSVNQSSSSPPGGQREEPPLVPTKAKLNHTFSGGTVSDFGMDSMFESSRQRPRQTLADEDAPPTASVNDIVNETPEAVSSRFSQRKPFEQSQNRFSLFRSSHPTTPKPAAPPPQQNTQPLYIVVFGYPPDKYSVTVEYFRSLGETTEAEQNSEVMNCFRIGYLNPAEAIRAVRKNGEILGGSWMVGAKWADVAQAEALLGSSLIRSTAQSPDLTSPGGGIESPSHSPNPFGAQSVARMSVDELGPRQGTPRTAEPSTPAVGTPIKLAPSASAFRRPGAGVPVTPAAVIQSTPSHLASGGLQQSPSKGMLGQVSDLIFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUJ4</accession>
    <name>A0A2G8RUJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUJ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUJ4"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="27490" checksum="7A30EE276ACB3361" modified="2018-01-31" version="1">MSGGHCDNCFQGVRHEGTPEGKIETIAGIECYVATPSGVYPKEKVVLFLTDVFGIPLINNKLLADDFARNGYRTIMPDILEGDPRSLDPPSDFDREGWLAKHGVDSWGPIVDKVVQALKADGITWIGTTGYCFGTQPVWRLALKGWSQVSVAAHVAGVRVPEDLQEYFDKAKAPLLLNTSEIDPTFPPEAQKVADEIFSGKFAPGYERTYWEGCTHGFAVRGDLSDPKVKAGKEGAFEATVKFFNKYKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVG6</accession>
    <name>A0A2G8RVG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tyr recombinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVG6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVG6"/>
    <dbReference type="OrthoDB" id="5598396at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="entry name" value="Intergrase catalytic core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052925">
        <property type="entry name" value="Phage_Integrase-like_Recomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605:SF3">
        <property type="entry name" value="P CELL-TYPE AGGLUTINATION PROTEIN MAP4-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34605">
        <property type="entry name" value="PHAGE_INTEGRASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24195" checksum="5F3B1B9B070C963D" modified="2018-01-31" version="1">MRLYSKPVKRQRALAPESRRPPGSALHDDQLFLAELLTGFHGLLRLGELVWPDNPNLRTSRKLSLRTSVELSPSSFSFLLHSHKSDRFFDGDRVLVDRDLSGASSLQAFNTYLSSRDAKFPFHPQLWLRDNGSVPTRRWFISRLRHFFPADISGHSMRSGGATALAVAGVPSSSIQAIGRWSSNAWQLYIRKHPVIVHAQVVAEQLSGPRSNGLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVH9</accession>
    <name>A0A2G8RVH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000050">
        <property type="protein sequence ID" value="PIL25521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVH9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVH9"/>
    <dbReference type="OrthoDB" id="2751552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="725" mass="80890" checksum="0406454B93F0BBD1" modified="2018-01-31" version="1">MAVTNASHISASRVEAEGDELRHTEAATPPGTPPAIDHLPEPPTPDANHPTTGTGPLPSGAGPVLANGVQVPQVTERPSFVRHCPSSTNRDAYKQKTGRQLAPLLIDESGMGARFHLLDNEIFSAHISGAAPSDADRKKFKTPTLKKGMLERDIYLQLGAVVKSVLDAAKCTKLRFLDTAAWFPDEPFPEPPTPPSTAPTVRRFIVGRPHFSAEALVGRCTRGYMAFDVTDPKKWVPCFLKDSWRPFVPHRTRPEHLVYERFKRRKVTERIATMICGGDVGGFRAQRTEVQNDLPDTNKPVLRIHYRLVTKEIGLPLWEFDNFSELSAIFVDALRGHRKAWDLAGVLHRDISVGNIMILTHEDRTRSGFLIDWDLSRLQCELGKGPVEPDRTGTWQFRSALSLRYPRKPYRRSDDIESFIHAYIYLVLRYHTTDVDSLKLEIETVFEGASRVGGIKIGGTHKIKMLRRGDLGFEIVGNIYLQQLLNDILLHCKTTYENINYLEMARLYGPVQGAAQPGPPAQHASGPQNASRVRPKRLMRHASDDERPSASLDHVHSHPEKQRQREDAQPGAPKEPCAIGLFLADPTTLIKRLVQHSEDADGYWDKAPDQFTARQDEDVFRPPEKHGLRSIGALSVTGSFPSEEAVEEAPAALPSRAEVSPANSAASFDQGTHSYDLPPATPRTKRTRAYEEDEDIVDDEGESSDWPRRSKRLKSRKGKGASRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVK4</accession>
    <name>A0A2G8RVK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000047">
        <property type="protein sequence ID" value="PIL25556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVK4"/>
    <dbReference type="OrthoDB" id="2764513at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013963679" description="Terpene synthase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42243" checksum="0DD204FC0D6EB6F5" modified="2018-01-31" version="1">MAAFNRLLSLLNLATLENDAINNPTPWSWGPWMARFQADRAPWAGPRWVPKTGFSRKQWTLVRSFVVAFYESGDNRLARNTFASGLSEGDQFEGLQILMSKIDHDWEQARIDCDADTILASMGINQLVDLHMETFVNRTSIPNIAELFFGRDAFVRPNVLLAVVSGWVLDVLSMTIDRWTLSYNERVQGIPDFQAAIYNACRDVSMPGSGIQEIADYFNTAASLIAQLNLTIDNERQRQLDYYRDVMFATLALIDGSDLAGRGLPPNMRSTLLKSGSWSEEECTVFREGFVAFLDGISLASRHVPESYREGVDVYRMLCEMTLGMVVDDDAPYLHLEENPENHTDNSAVWQDPAQAAFLFAACTLPHVYSNNGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVN5</accession>
    <name>A0A2G8RVN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_11318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVN5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVN5"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL25572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="422" mass="47582" checksum="2F80C9D8142E53E5" modified="2018-01-31" version="1">MPDVANLGLFLADWVGGMLRDHNLPVVGIRDIDEHLHRRRAWNRGLGPAALREYEHVLARRAQLLVRRLEEQEGEVNLGQWVNHFAYDFMSDMAFGGGSELLNEGDKNNVWAVLDKGMALATFFGHVPWLGVYVGHIPGAAWPLNSLHRHGEKCAAKRLARGSTTSDLFHYLNNEDLPDRPPPPARQLYDDGVLAVVAGSDTASSAMTSIFNCLLTHPEMYARLQEEVDRFYPAGEDAFNTKHHRDMHYLQAVINEALRLYPPIASASQRHLPRSAQGVTIGSIYIPPGTAIRLPPWSIHRDARNFTFPESFWPERWLIAPGHLALADAPLPSPLPEPSADNKGKAAFVHNEQAFLPFSVGPMNCPGKALAMQEMRMVVAALVQRFRMRLRDGWDAAFYEREIRDYFNATRPRVPVVLEKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWC4</accession>
    <name>A0A2G8RWC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWC4"/>
    <dbReference type="OrthoDB" id="3256331at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="14"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="202" mass="22416" checksum="A67E3B0285A92127" modified="2018-01-31" version="1">MSTPIAATLILSRDNPSNTTILDPDDKVLYTVHTTHGKVTVTHVLNADEEELASLEWRDVLPDKVTLGNKAPTSLRDWLHTSLVPFYLKDDVSLKDDSGRKYKWRGNAPGRALELFAEDDGYKEPIARFLHSRNDLQQLAQLVLTARAVQVRDIVVISFLFLEKSRRTNETASQSKADIMSAPVLSGVTGNDYNVKDGGIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWR2</accession>
    <name>A0A2G8RWR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11707</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWR2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWR2"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="574"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="373"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="485"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="702" mass="74705" checksum="6A7BA0B48A361A1F" modified="2018-01-31" version="1">MSAHSRSRGPSPSDSPTHTSRLSPDLPDQPPSAGLSTPPDELNGSDIKNSRKREREVSLEPATPQATTLEIGSETLDPKERRTPAKKNRTSDSLLEAPQEQAEDDHKLNGSPPHETKVRQISQGVEDLTWQNLNKDAPPDLDLTSKLSTSPTDLETNMETVTDPQLPSAQEDKIPPSVDTNSESDHQREAIVPPLARGENPPILSDTAGLEEDTVAAAGAEHPTDSHAPGAPGPSIETTPVNDSRKSIPDAPRFPSTQRRDSDSDQEKGLKRKLGDRTVSEALVPGDIPGGNGAATVGAMKRPRDDPEADPNTREKKRPTPPPDEDDKQEKTTSTTPPPDVTPKFGGFMAYASTTSPFSNVSGPRIFGAKQPSTSPWAAASTSGSPTTSAFSSGGTASSFSSFASSTPPFSGASDFVGKDARDVSSSAASLSQAHKRTGFEAFSSSTSPFASAAKRPKSPPPTPSSVLRSRSPSRHGTPARSVNAFSAYAAGGAQGFAAPTPKRSPPLGEATSSGEPNVLGGSSSGHAGSALDGGKDSGSGEESESGKEDKKKGASFKEQLRAGKDREEEDEDEEQKRLNLTEQEVHTGEEEEDTVYQVRGKLFALSEANQWKERGTGMLRLNVRSEDGGGARLIMRKEAVYTVLLNATLFKGMRCFSAQDPRYIRFSVFEGNTTTHYNLRVSNAKIAEELLEEITAHIPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWT1</accession>
    <name>A0A2G8RWT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWT1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWT1"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="233" mass="25592" checksum="F0C1BB8E6CB4E06B" modified="2018-01-31" version="1">MAISSTAPLGPNERLNVLHRPYLMRTPPILPPPERGVVENPSRERCIDADMELVRVLCDAHEEAARWSIGASAGEQQVSAVLFHYAYCAFASRWIQRRASDASIAARALTILAGLRKAGGWNERFGRRDGAPLPALRELAPVPAWGSPFNSAQFGGFGFAATSAAISFLNAGRQVPEMSSFARLQSAVMNQETGLLDLGTYMSLMALLPMDPSWRHPEYGHAVRDVAEQRERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX09</accession>
    <name>A0A2G8RX09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_11810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX09"/>
    <dbReference type="STRING" id="1077348.A0A2G8RX09"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="68"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL26056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="286" mass="31827" checksum="E079B12C382F2576" modified="2018-01-31" version="1">MLMKDSVEELPPAGLFDHLQAFPGDGLPMPDRPLIAPLAPMLVLREEYENGSQFFVKQIDWLMNQGWIGVRRARGDGDCFYRALAFAYVENILNSSDSLLAASSALSVLEATVPQLENVGFQRLVFEDFYDCLAGLINQIINPVNNRLLTIDLLLEAFNNPEVSNSIVVFLRLLTSAEIKTNPDYAAFLLHPETGEQMDPEGFCNNFVEAVGKEADHVQMNALATALKVNVNVAYLDGHDQHGQVSFVPFQNAPFTVIEPVNLLYRPGHYDVLDRRDADPLPPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYH2</accession>
    <name>A0A2G8RYH2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYH2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYH2"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013768937" description="Copper transport protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="20584" checksum="8AB93398738CBAD4" modified="2018-01-31" version="1">MSTISRVFLIAGVLLASGAYAHDNGMDMSMDGAMSLASGSMIPYLHFTPGDILWFYGWVPSSKGAMVGTCIGLFLLALVDRWIAAARSVMEVHWSKRAQMAQADRLNLSQKSSSTSWPGRIRDVATLRTGLPFIPAHDVSRGIIHGAQALIHFAIMLVIMTFQASFIISIVVGLGVGEALFGRFVAHAGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYI1</accession>
    <name>A0A2G8RYI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYI1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYI1"/>
    <dbReference type="OrthoDB" id="2749026at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="588" mass="66860" checksum="C31893B33F71ABF4" modified="2018-01-31" version="1">MWLLSTDRAELHYFANNFEAIGGYAILSHTWTGDEQTLQEVQAIGGQCRRDGTNPRDFVHRKVHNCCIIAERYGYRWVWIDSCCIDKTSSSELSEAINSMFRWYKEAEVCFAYLTDVPSGCNLHARRSAFRKSRWHTRGWTLQELIAPDFIVFLSADWDELGNRADIAGLLEEITGVPARVLTGEAPPAQYSVSIRMSWASGRETTRVEDEAYCLMGLFSVSMPTNYGEGKRAFIRLQYEIMEHNHDMSLFIFGYRVDQNHSFNFYPKEELSSRWSYLLANSPREFDSGFEYIPDLGTNTKQPYPPPISDSRLTGPFKGGIELPRVAVTNYGVELRVPIHESNGITIAVMLCQNNGRNIGILLTRDSRGKDPKRPRYFTGCPFTKPDTGLARYAARLVDLGDDLYALTFDRKPVKAAWRTIYVVPTPSDLDTIDSVTTPNLMINCNPASRFRIPRWLVTRFTTLQFEVRQVRNDESLQVLHFFLTLGTRISCIHHNGGHPDQPPQLWAKVDVLLPHVSIDVFTHSCSEDHIDSKSWATRSRVYSDSTGSVDSFPESFTTFHFLISYTTLSNSSSGVEESTCNEGSCQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYL1</accession>
    <name>A0A2G8RYL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYL1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="77" mass="8838" checksum="0413286F8902C3E3" modified="2018-01-31" version="1">MLRTPHPAPRQRKAPSSRAPFKLEVLERPENQPDQRPAPDRERSHAQARHAQEEEPRPVARDGQAVRDVEIEADEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYS0</accession>
    <name>A0A2G8RYS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000041">
        <property type="protein sequence ID" value="PIL26666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYS0"/>
    <dbReference type="OrthoDB" id="2753764at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="156" mass="16690" checksum="BE7963E5BC0421FF" modified="2018-01-31" version="1">MLRNGIMYFVVLSMLNILQLVLTLGFHAVPDGLFSYVWYLTFPLPSILVSHFLLDLQEAYQRSLAGLGTEDLSGSQGGASSIEFALGSVGATTDPVADVDHDIEEEDNQAAVAEGIPRSEGEPGDQSRAEYEDGFEILEVPRGGVGEETVGVTVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYW8</accession>
    <name>A0A2G8RYW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000040">
        <property type="protein sequence ID" value="PIL26687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYW8"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYW8"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="117" mass="13251" checksum="E622D494928A9FD5" modified="2018-01-31" version="1">MYKVYLDQFVFTPGVVALFFGSMTLLEGKSINDARERISEAYVPTLVRNWGVFIPTQIVNFAVVPTHLRFVTIGIVSLFWNAYLSSVNAKKQAQLALEHQQEHEHAIEDEKKIAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ00</accession>
    <name>A0A2G8RZ00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_11154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000038">
        <property type="protein sequence ID" value="PIL26740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ00"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ00"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="271"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL26740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="55604" checksum="387887B1F99CE075" modified="2018-01-31" version="1">MTFEVLRALHAVIGEAIDEIERVYKAHSPSQEDGAALQFPSLDAPYYSTLKNSVEVKKAEELRTEPAVFGATNRIVAACGQLTATVHKPFFQLVEGGQGGNLIAALEFLESTHIVEILREAGPGGLGVEEIGAKVTELRRAANPGAPGIDPSNIGHLLRLLATYHWIREVKPDVFTNNRLSSFIDSGKSTEQIKTSPTTKYDSTDGIAAYTSTIADETTKIHSALADWLLTGGAAPEGSHNGYPTAFNFAFKTQAKFYEWLETPGNEKRLARFGHAMNGTRYWEVTENIIHGFPWDELPRDAVVADVGGGIGSVSVLLAEAYPHLRFAVKDRASVVGIAHQSWGDKHADLFSSGRVSFHAQDFLEPQTPIDVPAVGTVAQPDVFLLRAVAHNWPDEYAVRILKHFRAAAGPHTKLLIVDNLLPYACRDDDHEGEGGAPGMSSLVPEGSSLLPNLGHASLNGYILDITMMAVFGAKERTYREMDALTQSAGWKISRVKRAVGSLWAYITAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZL6</accession>
    <name>A0A2G8RZL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000038">
        <property type="protein sequence ID" value="PIL26748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZL6"/>
    <dbReference type="OrthoDB" id="4505683at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL26748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="137" mass="15061" checksum="0CCDAB1D384C8A30" modified="2018-01-31" version="1">MSQCAIDCLDQAASANGCDVSDTFCVCTHQDVVTAAVNCALNSCTTEDVNTVPGLFKTECESEYVSSMRSPRYFIAIVPLDNATLLYSKVPDILITIFTVHPTCPYEVVAPASYEDYPIVQPSEHPLDIRVLFHSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZU0</accession>
    <name>A0A2G8RZU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZU0"/>
    <dbReference type="OrthoDB" id="2753572at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="24585" checksum="BFE3E17CE63803C7" modified="2018-01-31" version="1">MAPYVKYSGQEEKPVPPLVDLINRVLDPDGSHSNSSSTLAQSASNPQEAFESRKLPLREFVWGAKLVRNALPHYCIPPWLDPVDVDIDDPRKLPLCWYGVPFHSDMVFKYAHRIRVAVYMTRAHLGLKPGDLDEYKTWPKLVKWFEGESGLTMHLHQVWDEPKPLLTFFNNHEMARVTDDMWRIIGDLLDEMDYPEDCKPMWYLDRRQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZX7</accession>
    <name>A0A2G8RZX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZX7"/>
    <dbReference type="OrthoDB" id="2737129at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="272" mass="30885" checksum="D341A770E5612CC8" modified="2018-01-31" version="1">MTPYTTLCGQDDKPVPPLVDLINRVLDPDRASGDGGPSSSHLSDSESESSSGSAPDHPEASEPLKLPLRKFVWGSKLVRNALPHYAIPAWLDPLDVDVDDPRKLPLCWYGVPFYSDLVFAYAQRIRVAVYMKHENLNLKPGDLDIYETWPKFVDWFKGESGFTMHLHQVWDEREPLLTFFSNHEMARVTDDMWRVIGDLLDEIDYPKECKPMWYLDRRLDHVHAVTRWRVNEGGNLQGKAEGFWIFALESRLVYAATTVAQDAATPAQLSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0F1</accession>
    <name>A0A2G8S0F1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0F1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0F1"/>
    <dbReference type="OrthoDB" id="2746967at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="324" mass="37028" checksum="B865AC6D2EEBB4DA" modified="2018-01-31" version="1">MKRIAIVKSENERLFWNRCEKDYDEFADEWHIHPPQTSGHYAEDDERWLDECDASLITANGATYDPLDCPADVTALKLMQASVTRFDPPIPPFEELAYYRYGITACSGELLDSTANKYQGDMITKSFLLTNVERIGSENITKSTSAFLHGWKLGKNSIPPPLVWDIHPKSPCWLGNKPHPTIHIKEVELDKRTKFRRTFYHIEYKNDDLGWRLFVKDPVTALELYHSTTFINTSHAIAFLVLCGAAFHTLFLPSPREESQFMSQPSAKPCLSNVPMSIHGIRGLGPTNFNYYRATLKAFLESPRARCDHARWDRVADCNGSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0T7</accession>
    <name>A0A2G8S0T7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0T7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0T7"/>
    <dbReference type="OrthoDB" id="2736259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="36964" checksum="AE337DB3E05062A3" modified="2018-01-31" version="1">MTLVVLPNISVLISIWMETLFYGMYVVLFFSSFFVLSRTRNAIVQSWVIRLATVLMFCIATTHMAVNVRRLVEGFILPATKAETLAYLYDIHQPLNIVKQYLWVFNNVLADGIIVWRLYTLWNIQVCVLPILLLLCTTAFGLATATSLLPQIGAGNSIFVSHFSRFATTQYAISLTNNVLVTSLISGRIWYVTREVRASGYATGSDYRRAMLVVIESGAIYALTQVIQLAWYVAKFPGLYFVADSFVQIMAIVPTSVVLLVALGRTLVEESQAAASGALSEMKFTSGATKSSRTLGSMKDGYGLDRVMSGPKFKSGERPTHSQVLLPPGPAEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1D7</accession>
    <name>A0A2G8S1D7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BIR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1D7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1D7"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="599"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="93335" checksum="9003A42E6BB3D2EF" modified="2018-01-31" version="1">MEYYQNRIDSFGPAKSKRTKASSSKPVWPHPSSFKATPKTLAEAGFYFHPDSDNNDNVACFTCGKNLAGWEPDDDPFTIHYEKCRDKCAWAVVRCQTALGDGSFDFSDPTRHPTSKAMEKARLETFAKARWPHDAAKGHGANSKAMAKAGFLCIPTEAGDDTALCLYCELTLSGWDNDDDPYEEHVKRDKKKQTSCPFIKAYSGRSLGKSTNTKRPTSKVVTNPPTQTSKAIVEEEMEDSEDELAALSPLTVDMSMHTTKSKSRASKASSARPSSIAKTPASRRSTRGTSTTGRTPGSRTVSSEVEETDAGSESDAGRRATKSKRKTGRQTKARVSAIAEEEDEPESSRPTLEANDDVEMDDMPGPEPEKKKRGRPPKSAAAKTLTKGKSKKAEVKAEEGNEVEIDTDSPPAPPAKKVPARTRSKANLESDAEVAQPSKAHKRTKSTSKAKAMRDEDENKAPPVAGPASKKKGKQRTAEVVEDEEGPPSAPPAMPKAKAVSRAKPLAKYEGSEDEDTPSTAEGFSHSRADGVRNTTSRESKAISERKSSLSDDAGYATAEAHAEVDRMEVDDEPAPPPKVTKKTQQPPSKAVQPPPRANSRSTASGSDGSQRPSPVVNGVRSSSAVPPSSLSSLTSSSRPPNMLSVSKMSAQDSLKVIEIDSDAEASPERPVRHQPKTKPSASRDQSKGSINGAPNPASQAQKKKLQVEVIIPPNAPKLASSDDVQMRDERPASSPPRPPRSPSRPTKPEIPAPGTPVSAVHRSVHPSPEHDIRGEEDGPVARDTDAVPAASNSPRTYHPFLAQFPNENLAELTEEETDMTLEQYIRREMEVQYAQLKADGERRIEEFKQKAAETRKLIETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1H8</accession>
    <name>A0A2G8S1H8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_10782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1H8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1H8"/>
    <dbReference type="OrthoDB" id="100006at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL27630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="418" mass="45734" checksum="2FA6AE47A0C909DC" modified="2018-01-31" version="1">MGSVQVGSVVHTNEASYGGSSTYGTAEVAGVAVLVVAGAVSLVAVVPVLAALRWYGPKLGQTRIKPFFVSLLVANVLQAIGTIVNAKWVNERNVVAGPLCTAQGGIKQAGNVGMALWSFALSLHVFMLLFKRRMTLNAFMSWVLLGAGWFLVAFVVAIGPLAIETTGRGSYFGPSGFWCWITHNYPLEQFYLEYFFEFISAGLSFALYTAVLLRVRGNLVRTSGKWALRFVPHGERWRLAIRRDMVDSSMMQVAARMVWYPVAYTILLLPVTISRFYAFSGHDVSFRVTIFSDFVFNLQGIVNVALLLATRRFVPDTTALPLFEPRKRISMSSPEAFGITPFVLPPHPRDPVASADLSEKTPTQPDFDRNPSAGADAGMAAKEALSGLRRPELARTLSSTSTNSTSSIDSQTPFRHIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1I4</accession>
    <name>A0A2G8S1I4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1I4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1I4"/>
    <dbReference type="OrthoDB" id="3070249at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="768"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="995" mass="106676" checksum="009B6AA7EF113F67" modified="2018-01-31" version="1">MEESNQPGYDFSQGWDANSIDPRLFAQIQSHTSELAGALTLPPPPHRPADHEAYLHDSHPPQHQPRPRSAGSPPVPPPAPPAPEIHPVLAEVLKTVPGINLTTRITSGPTVLPGPSDGPLPPRFCSIKGCKTLIAGNSFFKMCEPCRDRYRNYGTTKRAKWKREKEVAVAELHQLHDKEDERRASEGLPPLPPPDNEQCEQWREYHPGDGDSTEPDVQPASATPGPPDAGEEGSGSALPPRMCTVSHCREILPGGYQFLRCERHRIQNRHHSKLKRVRDKEVKAQVYDGWAAAIAPRTDGERPADANPAPPVDADTAAAQEIAFTFSELSDQAREAMQPEYITEAAAVDFIHETGTGISATLALLADQPPGEDTPLGEPTTGVPPAARGTRRTNHVCSIKACSNLLSPSNPWKMCDLCRSRDRAGRRIKALRDSGLIPPEEAAAKIVEVRMEVEGKERRERKDKGTKKKNKGKKKKSSGAKEGMREGSDGSSGPSYGEGSGGAADECSSGARGDGDPQTSVFSSVPVPNHSHLVFMQPLFGQIASQLQHHFAQASGSSVPNPAEPSQGSGGSGGGSPSTDGADAGDATGAPPAAKKRGKGKGKAKVTQEESPSQPPDASMSASQGPPPHYPPPNGPPYPYYMPPFMPPYGPPPGFPYGYPAPPPSPSKSGAYSPPVFQPPPYGAYPYPYPYPGHPYPYPGQPYPPPPGPPGQSYSPPPAGPSYTPPPPYIPPPSGEQPQTQSYPQPIPPYPYAHPYPVPPPPPPHQPPTAEQPQQQPQQSSPPAPDEAPISAQSSAPAKRSKSSKNSVKAKSNAGKDISPNKPVDSEEPVPKETTFIVRTSETYEAPGTNRTRPSFSLKRPREHDESGDMSPNKRPEPEASGTYSQFRISLNGTPISTPPPPIPVTGVLNQSDFAPPVSAVEEMVLVPPPFITENGVSEKCGNKTCKRILPSGTSGSLCERCRERLKKKQVKAKHRFKLEPKVLLRRDLGTAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1Q5</accession>
    <name>A0A2G8S1Q5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_10834</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1Q5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1Q5"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553543" description="3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="5">
        <location>
            <begin position="76"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="531" mass="58169" checksum="7149082BDB9EB387" modified="2018-01-31" version="1">MGVTLWLSLASIPLLLYLYVRSNDAKIARLTPDAALFAGKRWTFEAVNQTAATLTSPSSSLFSPEELSPKTGRRYIVVGGAGFVGGWIVLHLIARGEDPRRIRILDIRRPIRQDLLEGSAAQVDFCQVDVSDAAAVEEAFRKPWAHIHDGPEPELTVFHTAAIIRFYERDESLQHFSDKVNLFGTQNVVAAARKVGTSTLVYTSSGSVSVRSNRFFRWPWEGAPEFFTQPISDDDAQVPKRHEHFFSNYAHSKWKAEKFVRAADRSPSAGGINGIMRTGCIRPGNGIYGPGGDLMLGPYLHHKSNPSWIFDILQSFIYVENCSVAHLAYEERLIELERGNPGSNPDIGGQAFCIADAGTPVTYREVYSAITELSKGAVTFIPLSATAMLTFATLVEAYYLARHALLRAPTPLATLGRLLPALNGDIVFLQPSMWSLTQVHLIFDDSRARASPAEGGLGYDGHITTLQGICKGIAEHQKNGGNSQQRVIAGHPTSDLGFDLVKAEKGVEEVIEKLGGGHKVDAKPKVAELQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1Q7</accession>
    <name>A0A2G8S1Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1Q7"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="22905" checksum="39A23AF1A287E86A" modified="2018-01-31" version="1">MTAPPPPPQPRTRPPAPPSTVARTASSRGSSPTSPLLILMTPASSSATGGALARTAAHGSTASTRRQRRACSMPKTRTKSRAPAGRGGCDRDFCASAARVAGRGGHPQRDGLGQGTMLGGLVACGSGPGAGGPSLLGAGTTAGGAGAGWGGEGRVDANAVFADGGLGGSCGEGYWGARAVPYAAASPLHPPRLWTSQAPGLLACSLHPRRRRRPRTHTGPSLSFPAPPPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1Y5</accession>
    <name>A0A2G8S1Y5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1Y5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1Y5"/>
    <dbReference type="OrthoDB" id="3200163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="25"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="640" mass="71008" checksum="B638D13C3D824F34" modified="2018-01-31" version="1">MIAKILDGVQEPVVLHDDLKTTFTGVVHEVSTPDAPVHQYLGIKYATIPARFRQSKVLTRYPPLTDCSRHGPICPQAKFKSVEEELFNLTEDCIPNQALEQSEFDCLNLNITCPASATPDSHLPVMLWIHGGGNRGSGANWVTDAGPLVQKSIQFGKPVVVVSINFRLGLLGFAASPALHEDNAAAGDEGVGNYGLRDQRRAMEWVYRFIQPFGGNPNNVTLFGEASGAGDILCHLHSSANEVAPLFQRSIVQSASVDLEVPNVQSAGWELRKTMASLRVQTVEDLRKLPVEKLVMLGENVRATDDGVFFRKGWSGSLVSDPTDGSWAAHEQHLGSHLESHSHHFKAARHLREHSRSHSRSRMPHLPHVRQPILIGDCGAESLLWSLPASLWTSPGAVKRIRAICQSLTKANTILRLYDISAATPADELPDRVLELVNDTRFAWPTEMLASSLRAERGGHGVWRYVFDQEGPSRGVPHHAVDLMYLFDNVPLPTLSTPSFYDCDLVPNENGCYYSDDDDDSSSDDEAMITKCGTGSDGTRYEYDADWAMPVVDDWTYSRVRNAVQERWLAFAYGEAPWREDRVFVFGPEGETGERSMCIFEARRRTQVWREALAPLGIGLVQKLGVELCNGPPADPRPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2X3</accession>
    <name>A0A2G8S2X3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2X3"/>
    <dbReference type="OrthoDB" id="2797568at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="164"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="902"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="945" mass="104253" checksum="7EB83785A9C1D787" modified="2018-01-31" version="1">MSGVNATPLTVKSKQHPVVVEETNKGGQHEGWAQEIVDRIHVSKDRTDVYLRKFVPSTARCPLTDDFTGRDLFSDWTPTAGKEKESYDTLVCGSRPSRRNRCPDHEKVKGFTELVSTFPEDKRPAFFKAYRVQQQFPFSAFAKDHHKSYPDIAVSFPGVKADALGDKPKWCDIALTMEAKAMEADDPFDKDGLEHVNRQIQLAINARGLMHAHGFLSVFILGVYGHRVRFVRFDHACAVVSKSLSLKDRDHVRLIQRFFWRLVHPCDGGVIVGADPTVRKLTAEDRDWVAPRLRELGIDLKTFVWEEARRAEVPCTPTGDLELDPSPGEPNAFILLKALGVNGRLFSRSTTAWLGLRDTRRWTGDGQLQAEDDGSESDSDSGDPAPLQLAVVKEAWRQLVRQPESDFYARLRAIDEDKRVGLPGLLCGGDMGEWEVRRWEASLYDDSTDAPQPATNNRNGVNHGSRLAASRTRAVDSELPPTASPTPLLSSLAVGEAPYPRPMHQTFTWRQLFGDKYWHRERSHMRLVLDKVGRPLNSFKTTRELAVAMRDAIRGHRAAMSGAGILHRDVSIGNILIVDDVLSKTSRGGFLHDFDFSTMSCAAPEGDLSSLGAEALSELLIGEDGTYYFMAINLLFAPSSGIVHTISHDLESFYWVLVWVVLRYTSYTHHFGDNTFLTVFPAGDDRQCAGAKTVWVKHEAKGLTIPGNQPLTDLMLALSAVMRKCSNDDALDYDLVLQCFDDALAPDKKWPENDKAVSRALPDLRTNSVMPANNRMGSKKKRHHRGGSKRKVAEGAEPPPLREDVEGPVYYDDDADPVAVREDDTGPAPRPTLVRQADQLEDEAAPAGRLPSKRLKTNSGKRSARDHRGDAAGTSGGSRTAPVEVGSTDVAGPSTGTRSRTRANNASRGAGSGRATGSRQASGREGGSRAKRSARGESGSRKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S408</accession>
    <name>A0A2G8S408_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S408"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="143" mass="15249" checksum="53B0A8DDCD822DF8" modified="2018-01-31" version="1">MATRLIPSAAPSIHRPESLAIPSVLEIAPGGAREHFHLDTQPGEAQSSPPASLPPSFRSHLDASLGLDGDLRRSGIVDVAVTNSPVVTTINTDSKMDSTSTESRATRSSPSSGPDEILEPASVTAHRRERNGWRARVRARLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S446</accession>
    <name>A0A2G8S446_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S446"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="273" mass="29056" checksum="30ED6D749D135DAF" modified="2018-01-31" version="1">MVWFCRRRRRQATSFGGETDALGSYVPEDPDATSRLRPGAGPQMPMSEAVTVASAHRLGPFPSTAPSSSSRSGPFAESGDTDSDGTRQLLLPTGSEGYVYVPASYRGPWGSALAAHPRNVSESFPPSSSPGGPVGMQSRPFSAVDQSDVMLKSFADFSPASPHTHTLPTDSDSKPDPPPRDLPLPPSHPSRGPDSRPITQSYVALPTDEQSAFGVGIGVSAGDGARFMRFEEDGGVRLAGGLPGEVLDDELDVNDDSRSSRWTVQPPPYQRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4F1</accession>
    <name>A0A2G8S4F1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08698</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4F1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4F1"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL28656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="239" mass="26547" checksum="68EA953D81CC9B53" modified="2018-01-31" version="1">MDLRYLAKVPAFAIIIAAEYITFRPPNPTPKNVARDKFCEPMLITLTARLYPLLGVVVNPCLHLCEVATVLAREFPSPLSDRVLAALLTHPANAHNLAISPTFLVGLLLIVLGAAWRKRCYDALGRFFTFQLALHKEHKLVTTGPYAIVRHPSYTAFLMTDLGCLMTLMLPGSYVYESGILQTSWVAVCVALWGAVLVGLGLAAVKRARVEDAVLREEFGSEWDAWARKTQYALIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4L4</accession>
    <name>A0A2G8S4L4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4L4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="116" mass="11677" checksum="1B026A3AA3AA4ABC" modified="2018-01-31" version="1">MSLNLLAEVRDATVGVAGPAEESTRGMMPGSSMPENNVTGPSLQNVSQAELRARAATPPGLVLNVADPVATTASARQEAPAGQARAEGPGATHSAQMAAASLNQNPALEVAISTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4T2</accession>
    <name>A0A2G8S4T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4T2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4T2"/>
    <dbReference type="OrthoDB" id="10054429at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL28761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="316" mass="34401" checksum="0C07627158B3A54B" modified="2018-01-31" version="1">MSSFNLWWTLGGTFVLVITLLVKAPVKNSAAFVFTDYENFTGWSNRGFVVLLGFLQAVYTLEGCETAAQVAEEAKRAEVLAPLAVVGSIIGSWFIGLAYMLALLFSVQSIASVQGTAFAIPIAQLYYDAVGKRLTLMCLTVVALAQFMAAVTAFTASSRLFYALARDNAFPFKSKYMALNRYQAPYFGVWTSVLVGCIISCAYIGSAVAFNAILSSAAIAVMLSYLQPIVIRVFWPTTSLPQRGPFSLGRWSWSVNFASFLFTVFICVLFILPTAHPTDALNMNYAIVAIGAVMLIVAACWVLWGRVHFVGPVKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Y8</accession>
    <name>A0A2G8S4Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Y8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4Y8"/>
    <dbReference type="OrthoDB" id="2562681at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="139" mass="15060" checksum="F2F29998E327E631" modified="2018-01-31" version="1">MTRTARASYPNAINKDRSEAKNGMDKHIPKRGAGPYNWGSLEDELEIETAAFEDEQAELDEEAGSPTAKREAERPATERRGSALTAEEIKQGIEFRKKALKSPDTDLASIARTAPVLSTSPTHPVPIVSDANTTAVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S531</accession>
    <name>A0A2G8S531_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_08907</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S531"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18970">
        <property type="entry name" value="CD_POL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="17">
        <location>
            <begin position="544"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="1108"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="1432"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL28861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1485" mass="166181" checksum="377FE7C99FE1FBA7" modified="2018-01-31" version="1">MSSSDASDAQVIFIPKSTPNITDGRVTPAVANTFEHGCVVHFKDKDVPPGRQVAKATANITNALISDWYIARHEEFDAMTFEEFMAEFRDQWLPHGWAMKLRAQILQASQSRQEPFDLFCIRVMKLNTQLRGSNLRFDDDGLRATISANLYPDLAVQANEYAITSIGSFKDWQDAVNELDIARRRIDAQVLSLIATNSKATTKQKASNPFVGVKDAPKPKLPKLTDLEYTYLRTVKGCFKCRKDVDAAHTSANCPNGYPDAATYTTCIPKGWKPSDKENKKPSAHSVNALNAAGGLEDTNVVAAIEALATSTGVLGSGSDSETYVPPLIAPHTILHARIIAPETYSDVLPMLADSAAPTVLIRRSLAVSLKLPLRKLPSPFQFSTAWGSGQKESSEWVKLAVTLKDYSWSSQVVRAIVVDSLCAPVILGKPFLQSNCLVEDFAACTLTDKRCGRDLLAPPSPPPPLRFLLWTVASSEVLLPKNALPSRMQAVSATAISFANSSPQPVGAASQRTTQRRTRLLSSVRLFVLKDANMVIARRQYDCPKKWRDAWKTLLEQHLAAVPKTDPAALPRWVNDYRVLNANTVPDMYPLPRISDILADCAKGSIWGKIDMTNAYFQTRVHPDDIKYTAVTTPFGLYEWTVMPQGCRNAPSTHQRRMYNALRPFLGKFCHVYLDDIVIWSQSLDEHRRNVETVLQALREASLFCSDKKTDLFLTELHFLGHIVSSAGIQADPSKVEKILNWPVPRNARAVRAFLGLVRYVASFLPNLADHTMLLTPLTTKEAEASFPEWTSAHQRAFDAIKQLVVSRECLTVIDHDDLERNKIFVSCDASDLRTGALLSFGPSLEQARPVAFDSAQLKGAELNYPVHEKELLAIVRALKKWRVDLLGVPFEIYTDHRTLENFHRQKDLSRRQACWQEFLSQYDFTIRYIKGEDNVAADALSRIDVAALPVEPSSVTIASTLLNATTVLAACAVDIVTDPALRNSVRFSLHTDPAWLGAIRAGYTKDKFCLRLRSLAGTLGVREQDGLLYIGDRLVIPRVPHLREGIFRCAHDALGHFGFEKSYANLRDAYYWPHMRKELESLYIPSCEECQRNKSLTRKPTGPLHPLPVPDARASSVAIDFIGPLPEDEGFNCLATITDRLGSDYRLVPCRTDTTAEQFAVLFFDHWFCENGLPLEIVSDRDKLFTSKLWDALHKLTGIKLKLSTAFHPQTDGSSERTNKTVTQALRYHVNRAQRGWVRALPRVRFAIMNTVNASTGFSPFQLHLGRSPRLIPPVVNQPVPSSASDAEVSELARSIIDALQTDIMEAQDNLLASKLAQASAANAHRAPERVYAEGDRVLLSTFHRRREYVRKRDGRTAKFMVRFDGPYEVLRAHPETSVYTLKLPDSMRIFPTFHASLLRPFVENDATRFPSRTRSHPGPIVTADGQEEWLVESILDRRRRGRGFQYLVRWAGYGPEADLWLPGKEVEDLEALDRFEAENPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5K6</accession>
    <name>A0A2G8S5K6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5K6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5K6"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47986" checksum="72DDB2B03AA510DF" modified="2018-01-31" version="1">MSSRKLDGLSPLGPHELFDQNALTFPAPAHFDLPTCNPGPLAAFDTPAKATTLPALPSPPRTSLLDEWYTLSTHLVPAAYLRVTPYLPLPAPLKWTPNKDEFRAAVRKTVGDVLSTKEGQWKGDLDSLPPNDHPLWICVNRYVRKGLKGKGNGTTLFLSHPNGFPKETWEPGLQRLITDYAGKANYQIDEIWSWEATNHGDACLLNSANLGGICQCFFLFSLCDFSSSTVADADCATPDDWRDNSRDILHFLLHYLPPSASSAALPTHLPRLADAEADSRKSRGLVDRRFLAIGHSFGGASITRAAIEVPALFEHLFLVEAMVRPMHHIAPGTCSPIQGLVTGAVQRRDGWASQEEAHKMFAATPFFAAWDPAALAVYVDCALYTAPDGQVRLKMPGIHEALCFAEERATFETFELLPALDARISLRWLVAGQLDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5X5</accession>
    <name>A0A2G8S5X5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5X5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5X5"/>
    <dbReference type="OrthoDB" id="448496at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="2">
        <location>
            <begin position="142"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="400" mass="43843" checksum="A2200E6D442B3F26" modified="2018-01-31" version="1">MHRVVLKAPRSFLALPASSTSLTATSGRRLLLARGLTRPANTAPRGSLYTAASSYPLPVRRFALRNTSAGSTSPAIQTPRLTTSARSISMSAPAAANADQSTSPGSAPKPEAAAQELPKFNFELSSVPANPLGEGRYIKTAAALVIGDEILNGKTLDRNSNYFARFCFENGIDLKRIEVIPDEEEEIVEAARRLVKTYDFVITTGGIGPTHDDITYQSLAAAFEQPLEHHAETLRRMGEMIRHRTDLGNQTDEQRVARERMALFPARAEVLYIASDIWVPVVRLEGKLCVFPGIPKLFQRMVDGLVPFLPLPPPSERPYRQQVFTNLPESSIAPYLTTLQARVKNAGVRVGSYPLLAKGVYVSLIGRDQERIQALGEEVAREIQGRLVSEEEAKKEKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6K6</accession>
    <name>A0A2G8S6K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6K6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6K6"/>
    <dbReference type="OrthoDB" id="2803164at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="403" mass="46141" checksum="D8C4B9B983EDAE42" modified="2018-01-31" version="1">MATTRPADITYGPTMVIAAKAIMPVKRSSLKLTEEQRVEMARRNTERNDCIEDTIREVYKFAEDKAKYLSETCGKKDDYYLRLIFSGGEKLGKGRKVNAYNAWSHQLAKEKNAEADPGEASNLLELQQEYRDEYDKLTPAQKMDLCAMLMEERDSRTFGVRVNQKGRTLDVMNTFWYITAMLLSLKCRCGIEAFVGVVRNNTEYDLRPQWFFTSSTINRYLTGAIKKWDVEVIGSQMEVFSIAGCEIFTFLQTNRDRAEWMKNEIREKMNAMYSEAIGQKGLTMQYKNFEQTVAIGHGLDLVGWTHDVFANPASLPASIEPLRKLLNALDIGDCHFVQLSHAERERCRLAFQEQVDAGAVKMRKSCSDKGKKRQLYTRRNGDAHLVSTIVQQYTITVVQTLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6L7</accession>
    <name>A0A2G8S6L7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6L7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6L7"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="86908" checksum="F447CDAECA59B509" modified="2018-01-31" version="1">MALPKAAPFSALPPDILDHIAFALALADPSGPPCPVLPLLCTSSHVHYHLSVPNNAHLYARIFRAKFDYRAPARRMCQEATYASALTNQLVHYSRALHNIRRGDIHSPSILHDFYRLFTLALENDGRNVHHLNWARYADFLHRYVLSRLWQDREESYGWPLESPENAFALWLYFFSLDHDKLSSQSEDEREHIMSLLRPYALYNFRYPPFLVPDNHVHLPLAGDPSDYQNHSAVTPHGYYPLYRDPTSVKHTVEHFGMHIAIAEPSIGLVAKLLYIAHYERWPVDIPDFIPCDRTEANELNLDGPTIADYDEFASRWAIQFPARGTWDWRDALNVEEGQRADSRTWRTDTKGESAAYDNDWERWRGCYDPWDVTRVKGPVYTFGSLSGMWGGQYLVPDVADYHVAMNSAEFLPVLEHPQMRASVTPLFFKLHEHHCVSPARPLPHWEVHDGDPFDEGVLNAYFPRGFPDAYVGLPGAGADVPRDRVLRLRKRGAVQEHVYETFVEGKENSHDEETCEICIEEREAERAARMEEVASDEDGSPTSVQWEDGHICTGNVPSVAAEDAGHEPVSEPENEDARVERIRREVQHVLGPQMDVEQLIEQVARQEDGSDDGASCCDADLASDGSTDISRTCSGILDIILTGETLHRHALAWGDFRIYGRVRAWDGLVVLVRTPIWHGPDLPRHDTFIFRGYLVGGPRGNLVGSWRHITGNVHSIPVEGPFVVSRIDERDAVDSEADAGAREGREGEEVGGAPEQQPAQDNGDGDGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6U8</accession>
    <name>A0A2G8S6U8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6U8"/>
    <dbReference type="OrthoDB" id="2757906at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55372" checksum="316F54D776187BCA" modified="2018-01-31" version="1">MDAVWDATTYSTFYSNQADYRSWALVSRAWRTCAQAVLFRTVELPDPVHLRRFAALLGSTPHLAVYVRVLRAYSRDLHTHDNILALLPTVLPGDVLPNLRSLLVTRVTEQDTWHPHASRPPSDKELAYMPLSLDSPLSTDTSTGSVDGGGSFTRGLEAHFAGVSELYLSYVTFETFGALAQTLHALRNLRLLSCLEVRWRALGAMPECLAWKSEGEGEGGGRGQGQVQGQDAFLAKLEDLTIAYMDLHGVERLLSALGGRSTALKGLYIDCPHYCPMTFWDPPSVDPETGVPLGIDLRAFSRLGSLWLALPYALSACRELPELVAALLRTWAPAKEGVPRKLTLTPSYESDFTRAEFAEVLRTLGPVIEDVLGVQSESEGEGEVGEKSVVRVRQGESGVSAEVEVEVEVEVCVVDKADMCEWWRGEARASFVRLGARGRLDVTFEKGFWPEAQWLDDSYEPEDEEALSASQQCIRRWKTCVGRRSTTEERVVTVYKLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7J1</accession>
    <name>A0A2G8S7J1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSI_08191</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7J1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7J1"/>
    <dbReference type="OrthoDB" id="29460at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013668103" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="25"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="31"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="338"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="600"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="855"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="974"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="438"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="696"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="722"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="745"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="863"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="976"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PIL29752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1010" mass="107791" checksum="9683E95BD91C112A" modified="2018-01-31" version="1">MPSFHRHPVSRAVLLTLLSALVAAQDDQKPFDCHVTIGQDKYDLTGLKGEFAAERDISLPPSTIHDTLSFNLCEDLTTKKDVPAEDQCPSGTRACLVRTTKKNGKDDQVLSVIPLANSSASAVSYEATTSPKGLQLTFAGSSYPSPAGSDPIPQHLHVKLLCSSNMANLNFTSYDGKDLYIQWEAPAGCLFESPPDEGTKDPSKGGDDKSGSGGEKEQESVGSGLGYFFLLLFLAFVAYFALGAYYNYSTYGASGADLIPSTSSSSSVRLRLQEREWRMAKKQAYVVLVGVKPGVYTNWLDVTQNTVGVPHAQFQGFTYFEEASEYFERALRRGATRAVKLPPPLKDHDEDKDEDKPEGAGRKNLKKPEGRSDGGPVKQRRRRIEDSPAESIAQTPASTPKGSSAGRAARDAQIAAALAGVRRNGIGPSASSPNVISSDRERRQQQERSSRRTAALARSATEPAYHFQVQPQVQNSPTVSESTRTPVHTRPRSTRRTVELPSPEPDARTRVRTRTRETRTGSEPHGPVSDIPTDETRTTNRFTNSPGLSTPRIRYAQSLSYASSPSLASSDIRTHISSPSSFGTRYFPEDWLARIGLAGQRREAGVDRDRRGDDRNSILSTSLSKYATAPNTPEQVSTELEDEVEEVRGVASASPSSSVHDRAGLSKSSSSSPRSAVTRSKTWSSAPSPPPATATEVISSPSATSTPRHTGSTSNSTGVNYSLSPSLASVPPSSPPSEPKKKTATRVTRSLSEAQVQTESPSTQARRRKNPEAEAGVQTDSPRRCKNPEVGVQAAPPSPHKRRHLDNQVQTSPVASALRASTAVGDVPVRPLPGGFPCACEHPEYACINCGERPRVEEGGGRSAASSSRSSRAPSTTTASPVPSEFSSAPSSPAPSGTPASASAVSSLVSTRSNSSRSHGGHTPIMGPSESRSYSRSPTARIQESLEMMSFSEAARGVGAEVVVHDVSFDPRSPIQRGTNIPAGTSGSAVRPSPAMAPVPMGSLGLLFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7Z4</accession>
    <name>A0A2G8S7Z4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_08072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; carnitine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7Z4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7Z4"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000001">
        <property type="entry name" value="Trimethyllysine dioxygenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF51">
        <property type="entry name" value="TRIMETHYLLYSINE DIOXYGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0124">Carnitine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="10">
        <location>
            <begin position="22"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL29865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="326" mass="36143" checksum="83A3358B485FDF29" modified="2018-01-31" version="1">MSQPLKSERILWGSKILQDPPTVTYEEAMAPDGQGLFKWLSRIDKFGFCFISGVPATPEATEELSRRIGFIRETQYGAFWDFTSDLAKGDTAYTTLALGAHTDTTYFTDPCGLQLFHLLEHSGGKGGATLLVDGFYVASILKELNPDAYDLLSTVPVPTHAAGEADALFTPSTRNTPILKHEAGELVQVRWNNDDRSVLRDLQTDQIEPWYDAIRTWYKLLSSPDSEYWVQLSPGTAVGTYYPVPSFRTSQPSHADVTSLVVDNHRVLHGRSAFDGKRRMCGAYIGMDEYRSKLAVLTEKFGPDPVTRDTAVGSSVNGRSVWHPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8D6</accession>
    <name>A0A2G8S8D6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8D6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="12170" checksum="FB675EB5A659F82A" modified="2018-01-31" version="1">MIHPPPYFHPLPKSRGHPRLDLDEQGSKTPWPRTPPPSHLRPLEDVQVCELLELPHALSVCLHDLLVIEQHPPLSVRPDVRDVVPRVDGRALMRDKRLETEPRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Z8</accession>
    <name>A0A2G8S8Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Z8"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23341" checksum="1F2E96AA7003431D" modified="2018-01-31" version="1">MPSYAVIGASRGIGIEYVRQMASRSDTVVFAVVRNPERSTHLNTSAAGLKNVHIIPGDVVDYNSLEYKVNSLGPIHAMTAFLPLLRTSDTEKIVVIGSGAGDPSSSRVLYLPHMVAYAVTKAAALLATTKFAVNLQDEGFVVITLSPGMVDCSATAGADSEALADSLKELSASVNKNTGLEVMPQTPEESVAGQLKVIDGLELSHNGLFLQHTGGEYHSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S917</accession>
    <name>A0A2G8S917_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S917"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="141" mass="15654" checksum="D61CBC6A276DACBF" modified="2018-01-31" version="1">MKSKTSTSPSQRMCENQRKKGKCGLGEAPTREETHVFLESLALLARLSHGEARKASLITSRGSLSIGAEEYRVWSEVDAWRETGERSTTRESSERAGGDGLARMKRETRTSDVAKHQAGDKEEALAGSRSRVEKTDERKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S988</accession>
    <name>A0A2G8S988_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S988"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="128" mass="13163" checksum="7C9C288EAB763FBF" modified="2018-01-31" version="1">MPGSLPPRPAASPSRAGAPRLRSEAKQTARERRRETGDGKRAGADGRIKRTRRDIDIIGYSSRGFEAVPLPLPAAASASRNGSSTSTSPGPQQPLSGSPRPYATAYAGGAPESASYHASLSSLSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA02</accession>
    <name>A0A2G8SA02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA02"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA02"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="324" mass="35968" checksum="CE5F107983FDD27A" modified="2018-01-31" version="1">MVHHPEVDAAIAAIEDRSLSPQQAADEVAKQCGQFIGPAPSHGSPTEGDEEGCEDSRVDQFFWSFWNEVLRLAQEDVSMHDRIAHIMAALKARGSEGCEGWKLWGEETDWSRLPVFSLASREEMNGPQPFIKERGFLDITAPKAQALLAGDVPTDDEPDTRELVRCRKVWLNTNAFLARLWALNVWDGAFLGIASMRMHLEPLTLSSTSGPTGTVGRWRDGCADPDELQIEVAALWLRIAGAKMYACREIMGPKGNPDWEANRGCPGGSGGTWDGVDGYHPDRWRHWKGILQEVAKGSWRRNVIEAAQAAIEAMEKYEREAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA48</accession>
    <name>A0A2G8SA48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA48"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="227" mass="25199" checksum="BBAC9B809601E806" modified="2018-01-31" version="1">MNAVGKWTEIHKYTLTVLAHATIRGTGGVESNLRLGRMIVFVLEPGPTSRADSASADVNPASAFILSKVNNQDGDHVPPVRELVSETFGRRGIEGGFRGESSDTTPAGFVPVLCIVEGTSTPTILRYPVYYPSRHPDNAADEKTVGFFQDINRIFFGFINNGIVIRAPADGQIGAPPCGVMVRAKKRWRWQQNQRLWQDMDMAVPHQNPPFQTTGSATELWMRFQQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAG9</accession>
    <name>A0A2G8SAG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAG9"/>
    <dbReference type="OrthoDB" id="2742236at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708296" description="Transporter" evidence="1">
        <location>
            <begin position="20"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="18330" checksum="4265E029EBD14416" modified="2018-01-31" version="1">MGPFTSTLTVSLFAALSFALTLPKRQTTTIYQSPFSGTIVAPVADEVIVPGVNFTFQYDNSNWCESGFSEFIVYLTSGTTPPPFDNVTVNGTLADGTYILDMGEYVVPNFAGLPAIGTPPPSSMVLPATIVDEVDNATQVYVTVLQEYDSCPGHIAKEYSLTSVPVTLGVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB74</accession>
    <name>A0A2G8SB74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-NAD kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05675</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL30982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB74"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB74"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013795685" description="ATP-NAD kinase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL30982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42646" checksum="9B6A90D5E0CBD3C4" modified="2018-01-31" version="1">MTMWRALPALFPALASTRTASLHLLARRTLHSAFPQRSISLCHPTTLPRSKDGLQARRTYATRVTNGISPASVLIVNKLRTKPVIDAINTLLAYIRSNYPGVQIFHEMRSDIPNGVQVWHPGPDADPIDLVITIGGDGTILHASSLFKVGAVPPVLSFSMGTLGFLLPFHIDDYTKAIDSAFAGRITVLHRMRLSCTFKDSGGDRIDTQAEDWQVMNEIALHRGSSPHLNTIDVFVDGQHLTEAVSDGLIVSTPTGSTAYSLSAGGPIVHPSLSAIVLTPICPRSLSFRPLVFPSSSSITLRISERSRASASLSMDGQVSHLLKPGESVTVRASLYPIPCINRSSITEPSEMREGEEGAGPGKEDDWVRDINNLLQYNATFRSKALTRHQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBR2</accession>
    <name>A0A2G8SBR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_05904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBR2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBR2"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL31206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="476" mass="51964" checksum="1938157A374ADF2E" modified="2018-01-31" version="1">MPVTSPPTITVHAHSFPDFTGDKVNGRYELVRLLGTGTFGVVYKAIDHEADCQFVAVKIMRKAGRSDAELVVVKREVLLHTVVSGIKGVVGLIDAFDDDKWCYMVLEFYPGGDLYGQIVDKESYYENDELLRQAFISLIDAVQACHDAEIAHRDLKPENILTNEDGSELYLADFGLAANAKMVSDFGSGTHIYMSPECIGETTGMQPYDPFPSDIWALGVVLINMISMSHPWIQATASDPQFGQFLKDPDFLYKAFPMSAGAHTIIRATLELNPAQRISLPDLREAILSLDTFFRPMCELGLELQYQYRCAAQDTPTATPGCWDSLFATRPKSVPGPTPLDALNIYAPLPSTTSVRAIRHRSSDSASDGVNTVPPSRADTPACTSCFCLWSSPGSGSGSGSGSTSRASSDVSSEEELVTPDGSAGATVVPSKLDSKLEMWEQMMMEAFQEEARAEHDDGWRKGSGRAVRVTRCRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBX4</accession>
    <name>A0A2G8SBX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBX4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBX4"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="396" mass="42856" checksum="2A4775D2CF8804CA" modified="2018-01-31" version="1">MATGHPTRPTSSLPPLRSLPMSTLSQITAAIDNLHALYRPTALAALPQPKALPKHLVHDTSVPDSGYASAEGEDEEDDECEDEEDTFDIDVLRSDSFEREFTIRWLTGFTARSDSWVYPPGCSEDESDARAVLVDAAASLLGSFSGEDEEEAVTRTFTFPTTFGSSGVGAVHVELNDAALLTDDHTSVGLQSWGSAIRLAERMCLDPSAFSLASGQRILELGAGTGLLSIAAAKLLAHPSSIGAQVLATDYHPHVLDNLRDNVSTNFPSSTSSPHSSVEVLPLDWQNPVFEGPLAEKFDRILAADVVYHPDHARWIKACAEHLLTTDGLFWLIIPLRSTGRHEGMSDTVDAIFPHGPSGKNDVQELVILGMEELRKQDGVGRVDEGGYKLYKIGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCX0</accession>
    <name>A0A2G8SCX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCX0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCX0"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="238"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="634"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="876" mass="95912" checksum="0EDFCF7657EEE374" modified="2018-01-31" version="1">MFSSWRHTVESLSQPPKQDASSPNGDEAPVRSSIDGVRSSLSSSSHLAESALSSLRKSLAAQRPASPGANHARTTSASSPVAEPAPISSPAPSPKPRTAGRSTLEDRLRAKFAIGDASNSSTPTASARTSPSPVPTAEHPLAIFPSVSQDQDAPVVKGPPNPLSPTSTPLPDSPLQSPVVDGANSLETLPPTDVNPLILSMQSGSSSSAEEQVSQSLLSPVEVPPAEVVQVVEAPSALETGSLEETPVLATSPPANENVIQLSSQSAPSPSSGELHAVDDDFSSDTSTRHVDAPADTPSETPSAPYISVDDPHAKITVNEVNGDASSDPTNAVNDEYPSPLTPIEDASTTGSETVQHGAPNGKSSDGVDVEALQKRLKLVEQRFTDVSTSFKRLQAEKVAADRVLRELTSVESVTEVDVLRDFLQNMNFKMEMAQDEIRRLNGKLTRQEERIEELRDIHRLEVKSQIDQIDQLKGQVEEAEKLLKASQGSTAQVEQESAKRKAEIEKLHSELDKAKNEAKEEEEKRTKAIALLKTVRQKLVKAEKERDDATKEVGTLKEVEKAEREKEKAERARLQGEIEKVNVEREMAIQGLRAQFDKEVAAAKERFDKELAALRGQYELEAITTKTTHVREIEHKKSRIADLENTVKTLSAEKDELFDQVQLRQAETESSQSHLESLQGQNTELQYQLREANDRIQLLQEEFSDVRREQEIKGAPSGPSAEEVTRILVAAESKHEMKLDDLRRRLAEAERERDEGEARWSKTVKERAREVESLKAAINSSQRSKEAETEEAQALEQEIESLKGEIQSYQTQLKDLLAQLEKAAEVEATVKDQLAEISAKTGDLQQFVDEGKNRETQLRNQNKAGGLLVMVAYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDS0</accession>
    <name>A0A2G8SDS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_06628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDS0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDS0"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="154" mass="17578" checksum="64D13E2EE1099AC5" modified="2018-01-31" version="1">MAEQIEKAFQKQPIFQDAKARGGKKVSTKEKRWYKDVGLGFKTPAEAIQGSYIDKKCPFTGEVSIRGRILTGRVVSTKMTRTIIIRRDYLHYIPKYNRYEKRHKNLAAHLSPAFRVEVGDVVTVGQCRPLSKTVRFNVLRVSKNKAAAKSFGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEF1</accession>
    <name>A0A2G8SEF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEF1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEF1"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="229" mass="24354" checksum="7223A49E59DBBD03" modified="2018-01-31" version="1">MSGGDLPVRATSEDLALLSLIASYSLQDVDEIGGRRRGKAIDGALSDEEIAFQLFAEEARALQTLVGDAIFARSLDQALQTDTALLEEHERIEKVEREDREAVRALTERCGPTTWPKGSSLSKKSSTSTLASFTTATSSTIVSPTTNGNNPEASLAPSSSSKQLPGMSRARHALSVETTSAVLSFAHLAGTPTTSDVSWTYFVPPPSTNPSFHPPVAVSPSTSQRSDNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEH6</accession>
    <name>A0A2G8SEH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEH6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEH6"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="221" mass="24513" checksum="936E3D5E98161B67" modified="2018-01-31" version="1">MSPTNHDGMPSPAHEIRITSHGKIKNWVTFALEHFQNHEDIPLVLHTFPASTKGKGSVPNGDSGSETQNDGPPVDSAAKGAKPNRLHPSMATIPRLVSVVEIIKREYLKTLDPALAQAGSLSGLHQYNEVRDLEVQGFLEDTVDEEQLRIESLAHALQGRNHLKQKKVAFMRVSLCRKEAPELVRKGITYQQPAVRKLSKSTRARLKKKLRKAHSEIESGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEW8</accession>
    <name>A0A2G8SEW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycopeptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEW8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEW8"/>
    <dbReference type="OrthoDB" id="3342934at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013647914" description="Glycopeptide" evidence="1">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="15623" checksum="467903F0A1030CB5" modified="2018-01-31" version="1">MQFSLSAAAFVALAGLVGAVVGETHIVHFDNRCNVTGTPQLIRGGQVLSNGSDYTSPGPLVSAIAYLQTGHCGFNGENCTLIETTLINGGSGSNTDISLISPHKFSVTSGFGYYNGCDGAGADCTDQECPEQYHPVPCSADNVNLAITFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF22</accession>
    <name>A0A2G8SF22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF22"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF22"/>
    <dbReference type="OrthoDB" id="2749397at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="407" mass="47405" checksum="8829FBE344702792" modified="2018-01-31" version="1">MNKSTEIAIAAKQGKIEKSLEELLPDYALEYKRVFEKKVAERFPPSTPWDHAIDFKKDFDPHKHRTWHKIYPLTVVERQELQKFIDENEAKGFIWKSSSPLASPFFFVSKKDGSLRPVQDYRALNKGMVKNVYPLPLIDDLINKVQGATVFTKFDIWAGYNNVRIKDGDQWKAAFNMPLGLYEPMVMFFGLCNAPATFQSMMNHIFADMIREGWLIIYMDDMLIISNDLETHRIRTKKVLKRLQEHDLYLKTEKSEFEVTEVEYLGVILKPGQVLMDPVKLKAIFEWQTPKTVKQVQAFLGFGNFYRRFIRDYSQVVHPLTELTKKGQAFVWTEGCETAFQDLKRHFTSEPILRIPDPLKPFQVECDASNVATAAVLRQQGPDNLWHPCAFLSKSFTEAEHNYQIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFC3</accession>
    <name>A0A2G8SFC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5592585at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="140"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="912"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1154"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1495"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1552"/>
            <end position="1568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1574" mass="176226" checksum="4D72581B614E66D2" modified="2018-01-31" version="1">MDGHFVKADSVVEFLDAFLPYPSTAPKRRTRRKNPFENLVDADKWVEAEVFAHFAVTSQRLCPKLVLTTSERTPDPKGVDKTQQKVDAGFFHPDDAPTNGQPGWPFDLVPVEFKNRKQGNIYDPLDDKAEDEGFESQADSRKDVRGQLTTYSELGHELQHRIFLLMLLVIGRRYRLMRWDRAGTVVTPSIDYYENPDDLCEFLWRISHLDDEALGLDPTAIRLKGDAFDELDTIAKPLRTDVDHTPRVLKEHQLVGEFCYRYVREMFAASIQDRALPRYKLHISMGDTLNTFLVGKPAAVARGMVGRGTRGWVAWHCEGGCFVWLKDAWRVSFEGIEREGDILARLNRAKISSVPTLVCHGDVGGQMTLTADWWKRRNGNNTATSAAPTSTPGEPSSADQAKDDSRKRKRPLEDEGIARPAEYSLRRGPRRACRGSESPDDTSATANAQPSALVEPAEPAPGKTSTDPAVYAHDCHIRRHTHYRMAVAEVGMPLKEIMNGRQLATILLDCIGAHHGAATSRSLGVLLHRDVSDKNILIYPKIKIKGSKKGKRSLVWGGILTDWEISKPIPKFGDEQRARQPVRTGRWQFMSANLLMNPLQRVMIEDELESFFHILVYYAVRYLKSSLLTDDDAAHFLEACFDCFAVHNKKVTCGSQKLYLVKYGEPSDPDIVFIHPMYMGDLPITFGSEALNILVAAMIPCLRARYKVLAWNEWLKSLPKDNPAHPQCKRRYETPPPQGPSSSHAGDERPRATCTRGAVDNEQGCVPRGTRLPPPPTKDDWKDAMRIASHNFIKAQFRSALEDGTWNIADRVGDRVPSDYDWHFITAVRTHHLTPGSTLSTVPFNDLSTGREGLEKHRIHVATYRCSDVPKRGHPVWADQKVSFQFSRYVAGADPFEDNELDEDYTDAGRERKKLRNHVFAAAELLFASQQRISLFMVLIIGRRFRLLRWDRSGVIVTPSIDYVEQSALLCDCLRRLSLLDDLSLGIDPTATRLRPRDADFKRMDAAALDDPCDVDHTERRLEEDEIGEAFVFRYVRSSFRDSLSADWPRYRLRVPDRDNTREFLVGKPLHLPSGAIGRGTRGYVALDCKTQRFVWLKDAWRASDLVIEKEGDILERLNLAGVANVPTLVCHGDIQEQITVTNKWWDITHDARPSCSSAETASPGGQKRKRDERTSAEGSLPNPTVQAPTATARQPCPLRRHTHYRIAVEEVAMPLAKFRCGKQLASVALDCLRAHHQAATHPKTSILHRDISSANMLIYPKVRPDEGGKGQSMCWTGILTDWELAKPVDTPRPMQANRVGTHQFMSVNLLGNPFQAVAIPDELESFFHVLVYYSVFYLRSNCPIPDAWINTYFLANGMPNMYTGGMKTALIRHEGRLTTLAGNRPPFPGSASASSSSSTSAAAASASATSASSTGVEKTNPEGAAAAKKTKPYVPTPSFSDDSDYAEIMAEWKQRKPPDTTPTPEERELAHRVENHDFTLDFIAEVLCDKGWSDDDRLSPRPAPASNPHSEPEPEPEPARADAAPAPAPKRRRKAAPKEKTVVALAQTGPTTARQTRSQTRATSSKTRPGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFD2</accession>
    <name>A0A2G8SFD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFD2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFD2"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="236"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="421"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="708" mass="80738" checksum="619BA0B3ED7D344C" modified="2018-01-31" version="1">MSHGDKFSTPVNSSSRFISPIPRSSAIKRDSLAAELERDPQLSTAKRQQRTQAFSSHLAHASLERQLAAAQTTKLELESKLREKDLLIERLEGDRRWLAEREKEEREEKEREREEALDAKRKADSELRSLRTQLASLREQHVDLEDEHSTLSRSTSQTISSQKSQVTTLARQVSLLENQLEEFRQLAEERAHAFDELQAQFDELNAAQDSVTLNHGQEDEDWTVVREELHRQAKYMRQLESANTKMTVELNVLREKQTSVEVLKEQKRELERKLHGAEDLREQVVKLEAELDAARQAREEWASTAQPATPSKTPVSVTQSLSNLRLTHAKLMEEHGSNVALLRHRDQTISELQARETQLQETVDSLRDEVRDLKGRVARSEHKAALSEREVSFLQAMVASFNAESAANGDVKLEDDASKPLQQLEALVKDYKGVVLALENELKHVRENTVVAEDLQAKQQLLAELERERAAKEEAEQALKEAESESEKQLEQIEELEQTLFELRGEIGAGRHLPPGVRVLSLRDNPAQQWEDLSKAAMDRLKGENEALLKRLKELEESGIRGLGQSASKEDLVPRESYEGVRAEMLKLDQELKAKDKRLQRLQEIFRKKGEEFREATASILGVKLVFYPNGGVRVTSQFDLNAAFVFKPTDSQNGGKMQLIEQGEGGPEDLPQLMRYWIEEQGCIPGFLASVTLECYDKRKRELEHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFR1</accession>
    <name>A0A2G8SFR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFR1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFR1"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654727" description="Transporter" evidence="3">
        <location>
            <begin position="16"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="13021" checksum="18B09A166B49237D" modified="2018-01-31" version="1">MHLVTSVIFLPSCAAHFSPGSLCLLVRAYFATSLAVYISRGRPALPLAAFYAGTTARPKTPKSHAVHVAEGTLDGDVPIPEPLAAHRRVDSAAPRRPSRETALRAPVHCRALPDHVPPAPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGI8</accession>
    <name>A0A2G8SGI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_04994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGI8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGI8"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="4">
        <location>
            <begin position="543"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="431"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="607"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="718"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL32876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="734" mass="82439" checksum="CD8CE3E7E910C0A2" modified="2018-01-31" version="1">MFSDDSDVDVEDVQLTVNEHYAKAYEYRKEREELAKLKEKYGSDVDEDADEEDSEDAESEDEDGEELTPAMDAAILRTLARIKRKDPAIYETGKDVFEEERKRTGEVQLGSRAPKDKSKPLTIRQHALAAALEDASGSRSPSPEPLTYVQEQERLREDTIAAFKAAVEGADEDVDFLVPREKTKDEIEREEEEYRAFLEREVGQDLAEIITVEDDAGVVGGIGGEDEEGEEEKPKKKKKSKTEKGKSKETKAKAGKSKQDEDQEFLMNYILNRGWIDKAARRLPTYKEITGKGKGKVGSDSEDDEFNDEADGGGGEEGLLVDEDEFDDVADAFESSYNFRFEEPDAAEIARYPRNIASLVRRQDTARKDAREKRKARKEEELLKKREEIKRLKALKMKELRAKLERIGAEGGKDLDESKALQDLDLEADWDPEAHDRQMRELYENDVGGFGGDDGDDELEKPTWADDIDITDIVPHGLDSDEEDVAGPSDKKKKKKKKKKKGGDDNDDGGVDVDEMDADVERAPPAFDDDEEWDGTEEMRKQKLEEYMDEVYGLDFNDMVGGMPTRFHYAKVDSQTFGLSSAEILMATDAELNTFMGIKKYAPYRKEGKGRTWDAQRGARLKDLKDTLKERGAGGAKAVEQAMEKTKKRKGKKERMREKAAAAAAAGDEDGAGEELEAEAVEDGPKEKRRKRKAKEEEEADEAGESDDAADGAEGASRKRKRRRHRKTAAAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGI9</accession>
    <name>A0A2G8SGI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGI9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="174" mass="18445" checksum="5C350E79B6FADE5E" modified="2018-01-31" version="1">MPCSAGSPHRTPKGSEDVSTRLSRKLCNQRAAAVRTIAPRSPAGLRCRNRPLEAAAGEAHRCGDDVGTTQEGRRAGTVTDPCQYDEGGVTTQTQDVDLPSARQAKPARRETRIKWKSRRTAGTACGSLNPPPGAGAAGDVMGIRRTHRSESLTPEGPHRQGTAPELCRQAEGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHD8</accession>
    <name>A0A2G8SHD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHD8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="276" mass="28987" checksum="2051B26D23B3FB9B" modified="2018-01-31" version="1">MSTGETPCPHGNFREDPRLAPILVWPEDQSLTRYAASNDDLEYWVTFNKNDANGASQTPRCDPDTMPFSPGPLSSCVNHPEGSMSRGAMPCSQASDLENRATIQSAPTAASGSTTVQVQIPSSAPSSDAFASPFCSPSLASFETMVAGLFPERPSPAHADTVDAMGTNCLPQLWTEQSTSTHCLKPHGLHAVDLGRRSLTQLATNSPELESLSYHGAIPGDHPYLASGKPQSIGAAGRAVSLSIGPASTGGVPSQFTLASEMFYGHAKNAIAGMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHU8</accession>
    <name>A0A2G8SHU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHU8"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013863111" description="Transporter" evidence="2">
        <location>
            <begin position="19"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="30888" checksum="238F63763DF8E7C4" modified="2018-01-31" version="1">MTVLRQLLAAIVLAESLALSSFADGPGPQPGQIKNLVTFGDSYTDIVSLARYNKNRSSCSHSPIHLAGRPRRRRDSLARPRRRRQLPQLFPFKFAKVGATCSNALTYRPFPSLFESQLPAYVAARGARDGAHAVDRAERRTSNDPEARGVTLDTGHDGVRGGLGADAVWEWGAEFRLPEREAVSVSRAEKRGRCMLTRPDATVARDARRGRQMIPLETVPLSLYAPDPYPNLYWNWNARRNTTEWSVFMRELTTSGNAIARLQLQLLAPSLKGAHIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIF2</accession>
    <name>A0A2G8SIF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIF2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIF2"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="178" mass="20432" checksum="01223220546FABF5" modified="2018-01-31" version="1">MYVDSDTLVRRNFDELFRLPYTFAAVPDVYVDAQGYVTAFNAGVLFLRPDSALFTDMVGKIATARYPAEQAEQAFLNQYFGAEALRLPYAYNGNLAIKKRTPQLWAALQDELRIMHFTMAKPFLQGDYDEVPMDQLEKNAAKVAHRKPAYKEEIAEWVEAWRETRRTYATKLAKCSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJD9</accession>
    <name>A0A2G8SJD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJD9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJD9"/>
    <dbReference type="OrthoDB" id="2756548at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="412" mass="42660" checksum="7D2BF16AF13F8813" modified="2018-01-31" version="1">MNHPKHPAHFAFWAKNVLERTAQVVDSVLHLRPCPVLSSVGWMGIQENTWALEGLQSLYIPAQVAPQKKAGGMTLRKRKATANSANAQSPAAADNDEPEKPRKRVRTTRASQRAKAAALAATPTPAPAEDGDGDEEQASSSSLLFSSGAAEALTLPPSAAPAAATSALDGTVGVSVTRDVKQEFIATTPVLQAIGLMLELPSVAAGDLLPPAAIVSSSHDHDHDNDNEGTASPALTTTPIPTTTTTPARRSTRARRKPAPPGPCSLVSTPLSALDTPLPSADAVLPETPESGNGVGKRNRSGSRGSSTAVSEGGYPSEEGTVVDAEIGASESPSPCKGKRKAVEIEIERADFGEPERELGQEREEGEQEEGANTKSAKGKSGSGSRRAPAAKKRKVSAAGGGGGRRRASRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKA8</accession>
    <name>A0A2G8SKA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKA8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKA8"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="532" mass="58811" checksum="14A20FAE6F04CE33" modified="2018-01-31" version="1">MDPVNHHLFSSSYPDYQNPLYPIYNPQQHHPQPHQQHPQQHQHQFQHPHAHPHQHQHPHPHQHPHPLPHQHPHASRHPSPGLSPASTPIPHSPHLFLQNHLPQAPPQQEPQPQQPREPDPPVDQIQDDAPMDEEPLYVNAKQYYRILKRRVARARLEEVHRLSKQRKPYLHESRHKHAMRRPRGPGGRFLTAEEIAVQKLQQEAETVGPSGSASIDGDGEDDDDAMGESTKDVDMAVDSPIEPSKLPSAPAQVQIQSQHFDKQREIRPPPALASGQPLLQPRPQPVGPTLQPQFQPPPQAQQQASMVPQQQPTPQPKPLPSPIPQAPPPMQSPPPPTQPTFNLQLGGHSTTPVSLMNIAYPHPMSHPATPAPVSPNPTPDTLNPLEHVPPEAYSRPLPCSLPHDHSLTMTTAAGTARPRPGAHTHSHPGQPGKAAHMPPSHPTQTAGPSAAPPPSITLRAPYHAAMQMHHVPHPHAHARHHASFINRAERLYSAGPEHNVLNISAEGIKGDMQRRGGDIMRFGAPSHSTNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKE0</accession>
    <name>A0A2G8SKE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_03956</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKE0"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110031">
        <property type="term" value="P:negative regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF190">
        <property type="entry name" value="MITOSIS INHIBITOR PROTEIN KINASE MIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="783"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="643"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="816"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL34245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1119" mass="121036" checksum="29C550BA569126DB" modified="2018-01-31" version="1">MTPLNITSASGQTQGSASTALLFDRLAPLSAPRFASVRETPQTKAETELHLRKQAETMTMLSIRDLDRSDDESGYDSDPDAIHNHSGTIEKQRLLFMGSTGGSAAAPFSSIKARTRTKGNGKGKSPGLEVLTRKGLVNDDEVVEAISPGGHVTKRRARSRPVSAELLESVHRTPVASQDKVTATPRINESKSASTVAFPSTRTMRTRTISNSSTTSSESASPRRRPHAAGATRTRTQSHTSRTLNRLQSSSSATLFFGPSIGPSTANTTKDRKSGRTSSANNKPASPLFLRTDPHPTQRPQFPNRHSYAGSGSPSAWASRSPPAVASSPVPVNARKRMESDCSDDEADLFFSSGPADSSFAISLQRGCTPSPKKKQKRESLDPLPKKFRPRDSGVVLSDSDDDLDLAFDDHTNFIMAAMPRASTSVSTVASSFDDHELVTPGIAPSAASGWPTVVNLDDDHLSASHSTSMGMGRGVDAFILRTLAAGGSVSTRGEAEPKRVPGTPVKKVKTAHLVGGVTRPWQSAVAHKIGFKDFDDVPGQGPGKGKSKPRKSLPAAFPGLGRPKETKTTKKERQIPSRAAASASERDIDVDLDDGDSPTMRRDAKYDGLGLGRPTTGLPPFTRPSGEGKPGKAHWLMRRSSSGAFSTASDGSSINATPTRLTPKEWMLPAPRIRTPGASPLKNALEAASRSTSGSSTSTSTVTNSPTVNAAVLPSGTSSHRARKVSQNLRTPAPALFAALNGQRPHTHAHPARQVHAQPAVRAGRLPAPTDEEAPGRFLRDYVEVDELGSGEFGRAMKVHYKDPAQGNDVFAVKKSKRFEGVKHRLRLREEVDILKHLSDAAARSPDTTVRLARRHPNILGYIDSWEEDETLYIQTELCELGNFAHFLWEYGRAFPRLDEARVWKIMAELAAGLRFIHDVNVIHLDLKPANIFLTGEGRLKIGDFGMASVWPRPSPPGEPQLIPGQKPVGFEREGDKLYLAPEVLQGRYGKAADVFSLGMTMLEAASNIVVPDQGEAWHRLRREDFSQVELDVSPELWDLIKSMMRAAPALRIGIQLVDTHPVVARARHAMERMRAQHGAVFGASPLGAVPAGFLDEILVRGRRTWDDDDDWEMDLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SML3</accession>
    <name>A0A2G8SML3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SML3"/>
    <dbReference type="OrthoDB" id="3058642at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="284" mass="32307" checksum="2BF7429C57A4FE04" modified="2018-01-31" version="1">MQGALDDTFHLLSHSEILRRGVQAFFSLEPVEDGGGTIAGLTNAVCIMSVYSRTTNDYWKPVLPRTSASDAYGWVTEYPPISRLKREQKEGRLKSNLLPYDYSPGARYDLSRPFPPELEDRYVCNSDILMKSKRALASWIWDACNVVLDHVLLDGAIPRCPDDLTAVREDAMERAVAFIDSQRKLYARRPEEPLGPSSSKALLWLRRILEQAPLAPVPGSALWGAPFPGLDFVRAEEERYSYYDWNEAYLERVFTAACEVVEELGAGRDGWRTVRWEVYDKYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMY5</accession>
    <name>A0A2G8SMY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helitron helicase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMY5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMY5"/>
    <dbReference type="OrthoDB" id="3366231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025476">
        <property type="entry name" value="Helitron_helicase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10492:SF57">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14214">
        <property type="entry name" value="Helitron_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helitron helicase-like" evidence="1">
        <location>
            <begin position="289"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="733" mass="83277" checksum="04986EB00E7C6DCF" modified="2018-01-31" version="1">MTIGNSDRATWAIGPISTPTLAWGARRAGREHKCSTCGIKLLTGEEAGFCCGPGGSRFSAVPPLPPLPPEYAPFINDPQVSSLSRILNLVFSFASLETTARFGDSNLPGFFAIGGRVYHRIRPTHKDSAVHWLLYDGFQRSKPPHERWANSLPPRWIDAMQAALQAHNPFVQHLRLLSQLDPQDCPEAQLLILDSGASEIAAVMCYENTSQSQIKPRTIAISRTSSDLHTQPTQISITSRLWEPLAYPLFFPAGTLGWGIAGNTDDITDPGMRSRDSEPETTQIWHYRARLLREPRFAIFGRLTNEYVVDMFSRNLEARLKYIRNNQRRIQQDDADLMGIESVADNDNIYLPASFLGSNRWASEQIADSLAIAAMYGAPTFFITMTCNSEWPEIQSQLRPGQEYHDIPVVVCRVFRRKLMLLEKALRSMFPNAGGLLYIIHCVEFQKRGLPHAHILVKYASDCIEPSDVDAVISAEMPANPADAQLVLKFMSHHHPPPNKPAAKYCQRELENGERHCRFNYPKPVIQSTYTDHSGRVHYRRRTDDDAWVVPYNIELLRKFQCHLNVEAANSSHLFQYIFKYIHKGPDRAKFRIFTAHDNAEPIDEIQDYWDARYLSAGEATWRILGFHITRKEPGVTSLPIHLPQRSSHHRQYARRSQDASKTLSLLERYFRRPQGSFSMPDNSLRTFASLSYAEYFAHFRLAKYDASKAATAGYFAEQDFGDGVVIMHVIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN42</accession>
    <name>A0A2G8SN42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN42"/>
    <dbReference type="OrthoDB" id="2743683at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="389" mass="43918" checksum="483CA3199BCD8A62" modified="2018-01-31" version="1">MRTLRDFGDHFREVYLQVENLWWNQIFGSLPAHSSLLTRLTIDSNYRKYPSSVFSPGMHYFGGIAQGLQHLRIHGVPCLPTDQFPNLTHFAVSDVNVYPLSTILSVFANMPSLEVLSFALVIEEGSATHCVPDTIVELPHLRQLTERHDISIFCDVLQVLPMIKIPSTCLVQIDEQGSNDVTSIAGLLYREAFPQNLTRLRIMPHHDMHPMITSSYENKKTIQYYLEVLNDAGTSGLILGIHSRYSGLWTAEDRTEVTDTFVDFLSDTVGAKLVSNPSSPPIDTRGLVLAQSPHGRTEIPESIVQPAEDGTFCYCPDLTSLYVYACRAKDVGRARRAAISPVLGLEWLVRELSVTVGVTRLEYDWWKPCAIPEGWSRHGVYPWPDRREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNA1</accession>
    <name>A0A2G8SNA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNA1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="107" mass="11709" checksum="3A5C33ECC2FFDBFF" modified="2018-01-31" version="1">MAFFNQVIFSQGRNAEVIQEGPEPEMEAVELLVNLDMVCVCNMLLIVKPLMHTDNLLFELHDLMVGFLDHQVHVGDSVIGMLKSGPEVLDVLSDLLGGPAEYGAAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNH8</accession>
    <name>A0A2G8SNH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNH8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNH8"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="467" mass="51829" checksum="79C98DC77497B423" modified="2018-01-31" version="1">MFCKSCNCNSSIATRVGFALIFCLNSMLAWLMKSPLIFEQLEKMSHGYLKMDCEGDKCYGVLAVHRICFALALFHALLSTSLIGVQDTRDKRAAIQNGWWGPKVLLWLVLVVVSFFIPNGFFMFWGNYVAMVGASIFILLGLVLLVDFAHSWSETCLENWENSNSNLWQWILIGSTAGMYAAAIAITGVLYAFFAGDGCTLNRFFISFNLALCVVVTALCVHPTVQEHNPRSGLAQSSMVAAYCTYLVMSAVGNHDHNTCNPLRRGSGTQYTTLFLGAVFTFLAIAYSTSRAATQSRALVGKDRKGAISLPDEGEHHAELGVVNTQPGRTENPRYQAMLAAVEAGAIPASALNEDWQDEDEDDVSGEARDDERTGTRYNYAWFHVIFAIGAMYVAMLLTDWNVVKQDSSPDHDQDVYIGRSEVAMWMRIVSSWICMLLYIWSLLAPVLMPDRRVPRFTPMPASAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNM9</accession>
    <name>A0A2G8SNM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_02088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNM9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNM9"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="104"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL35362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="204" mass="23338" checksum="7009DAA2F1019D49" modified="2018-01-31" version="1">MATPRPPRQSNGNEDDDRRNSLFRRSWYAMTEVLFPFSPSALASLPKKTFQPRPRYTRADNVPDAPQDEDGQMPTVRDYHAINHLPPQVRIPKKIATPIKVEGKVWFANERTWISYLQTAVLIGTLALALFNASKDQIARNFAYAYAILSVAVTVYGYAVYQHRITMIRRRDPGHFDQITGPVLISAFLFFAVLANFIIRVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPH3</accession>
    <name>A0A2G8SPH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPH3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPH3"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="84"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="643" mass="71576" checksum="CCAEDA07F8ECCA01" modified="2018-01-31" version="1">MYGRAPTRPSAASTLVVYLFVIAVLFLAYLHEPFLLSRAQQYTFAPFATQQKGKTKFPFPDFNKYIHTYTLSPEAFGIGAHDERVIVIGDTHGMNQSLHNLLAAVEYNPRKDTIFMSGDLLAKSTEAGSLAILDFIVRQKQGLCAKGAADPSQLTGSSPSTSQRKTKTPSCKPIYAVRGNHDQMVIQWRAWRDWFEQLQVPFTPTRLHSHLPFPSPLSALASFLPLGFGTASYDAGPAVGTGSEFLQLIEAEWLRDRKKDPNGAGSDVEEWIDVARKRAQGTWRAEWWKRIPGPGKGRAKKDWIMFGDHYNIARDMSSEQAQFLYSLPLVIHIPSEHFFLAHAGLLPYDPRKASDDKHQPLAHAPSADEEDEEDGDDGYEYPTIDVGSSHFQRPLSRTGLDEDEGVDQLRVLQEHALLEDIPHNRDPWVILNIRSIRKDGTVTRQANKGTPWAKVWNGQMKRCAGFTDADDDDLARSNASSVDPFPFAEGEDQAAQKKKDDEKELPCFPSTVVYGHAASRDLDVRRWTIGLDTGCLYGRRLTALILTRERGKSAWEPPVDDEYDDSDDDEEGDVSSDDEGETVAGGGFQGVNSRFARVEGGSAISRRAKGPKTWTRTIKFGDKHSDLEAKLVSVKCPKVGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPN4</accession>
    <name>A0A2G8SPN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPN4"/>
    <dbReference type="OrthoDB" id="3259746at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF3">
        <property type="entry name" value="CLEAVAGE_POLYADENYLATION SPECIFICITY FACTOR A SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013950192" evidence="1">
        <location>
            <begin position="22"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="197" mass="19385" checksum="780FC071B9BDDBA6" modified="2018-01-31" version="1">MYSTLVSVALFSALAIQGALADFTVDTPTITQCGSVQLKWDSTGAQSYNVAVVPAANPCDEILRDLGDHTVNHITWTANIPAGQQVMLSILDSDDNEAWSGAITVQKSDDASCLATSSSSVSASSSTLASASASSGTTLVVNAGAAASTAPAAPSSSGATAVGAANSGVLGNGAFSVRFSAPSVALGAIVAIAALAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR85</accession>
    <name>A0A2G8SR85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_01941</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR85"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR85"/>
    <dbReference type="OrthoDB" id="4506189at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL36279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="252" mass="27671" checksum="442FED6BC583B010" modified="2018-01-31" version="1">MPVEQALHDRVNLARLVRRLEKTVTDETWTDNGPTPVWIRTRGALQKVKHARKLLHNVETGDDASDSPPPMLPALPPPIPADIPSSVEESLPETEPSPLDPAATLLPVEDAAHELLLTPSDSHALTRGPINPSEALLPPSLPAAAQKSGTQATPAFMQNSAALQEELSAQLAQMATQLKRNAVHFASALEKDKAVVQETQEKLERNYDVMSKERVRLRDHHSKSWGTTWITILSLVVVLIGFVMVFLVIRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRE6</accession>
    <name>A0A2G8SRE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRE6"/>
    <dbReference type="OrthoDB" id="2754197at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013930164" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52012" checksum="DB95747F4A44DCBB" modified="2018-01-31" version="1">MNRTVLNVDVLLLVFSLAHKQTQLALMSTTRVLYREGGKQLLKDMDGVWLGTEPRLESFLLFMDADGGSRMRYLHRLILDINLNLSRPVAKRFKNMLNRLAPVSRLTDLSILHLEPLLSAHPFLSKAIANLTSIKTIDLFTVGKRSVKMLKSMQSELETVEFGGFDDQLIQSSKPDDPDLIMLLRPFSSSLRSLTVAGWCATVDPQDDAPQYPLLSALTLDEPTSPTTWHYSRAFPNLKCLTIMTTGFVTAEERLDEFHQANVAQLRRHGCWESLDWFEGPILELWLLGLLCPVSKLNLHDECYPVTPDILRGALVPARATQLRVSFYQFGLFRDEDFIRAFVEGCGATLKVLDLTIKISLSEYDEVGYDLDLGDVLDAITDMLRSFSTLESVTLELHFERCDWGKDEELPGEVFAEDMDVDAMCAALHEAVPSASHVRFELQDHKTRGNVTTEIGSEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRI7</accession>
    <name>A0A2G8SRI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01848</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRI7"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="694" mass="76404" checksum="ADC9218E32182542" modified="2018-01-31" version="1">MEPHHGSHPYHSPPQSYPLMADSLHYTTTPTHHYVPNAYYASQMHAGTAHMHVVAPSTMRQDPAAQRKRPKYTRSKTGCLTCRAKKIKCDETKPTCVRCSHGQRECTWPEGVPTRKKPTPRREPPSPIDGMETRPSTAGSSGVSDTPPTRGPTPPRRGEPVEMGIPPMVSRRHSDPNVNLSVAVNDGRRSAVAPISTSSHGYPMHSNNTHALPAIPEIAASYTSQPQYLHSYPSHHYSQSHSALPRITAHNDPHSRGTDSASPDSQWSSPQLLTPVDPIEPYFPTPQERNLIRHYCDNALSIIMAYPYENPVLAANFQFLFDGVRGTDSAVESLRAALLGVAAVHQSFLLSRSGVSSLAADEAMRVADSFRAKSNHLLVSACATPEGAHNDAALAATVAIALIDIFSGGRNWAKNVDFAKNLVKSRGGPGLLLARSKGYKANSVIGVSRARLLLEIIAVYELFGCLARGKVPNLLNIDCWWLTKTNPHDNVSYIDKVFGMSREFIVILARAATLVARALRPSTSKITEVSEDGEPEPRNGDGTDAQTREAEVLYKSLENWRSGASNLHERVQVGNCVYQHAAQILLLRDVLKAPPTDALVQEHANTILTLCMDCGQSRMGVDLTWPVIIAGSQLYGADRARVLSIFELFRTQCCYEIETSEFIVRQVWQRLDTNHPKADWRSVMQDNDLDVLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSB6</accession>
    <name>A0A2G8SSB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSB6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSB6"/>
    <dbReference type="OrthoDB" id="286814at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="51375" checksum="FCD0C45658129687" modified="2018-01-31" version="1">MGFSSTTTFAPSSVAAILASLFSDTASPQTMNEPTSLVPVGVLDPKVMNMVNFPMNLGVIEFFIDVLVAAVARAVIASRYKAAPPMKTPLLMRCIIEYIVRGLLDTRTILTAVVYLSDIRLTAYDMGDFVCERLAIGALMLAHKANNEPSYPGSQWFQLAQVAFGSSGLHLTRKGLNKIEREFLACLDWQVMPTTEKLLDHHDVFMRYARRDLEVYSVTQAQAQAQMVTTRTRPIPVPERAEPTYPRATLSVAAADLPDLMYPDTPSLSDGYSSDSSAGIITPPSSGHAYAASGSHTGRVGPTRKGRSPPCPYSRPPRRMSSHRTPGYGQNDPRSTITITSSTAVDSAMEARIRFYAADRGTVLRECGGSPRYVPYSPSQRWLHRRDRYDSAPTPSPSSAIAAELAAWNASLGFNSSSKREFAAPPTSTYPPYRRAEDPFCRRYQSWSSTMPGVAANDKWGTFGLFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST77</accession>
    <name>A0A2G8ST77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4050 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST77"/>
    <dbReference type="OrthoDB" id="3366194at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25455" checksum="7AB323A20F394547" modified="2018-01-31" version="1">METLSESLLLEPQSEPSPPPAPIVVTVPSSPDDGQNVRPHLLRTPPLRAFELPAPSDITPRPRALFDSDNLSPPLTFTSQSTDTSMSPFEEQLAAAGLPPPGAEHFDARRALWWAPGPHPPSPTEPNPSRGRLETLLAEPAALEDDRVWDAGLDRVWRGLTGGAKLKHRLPLALVIKILQAGWIREGTWPKGAVAPESDGDVPVPEAKATVSPLYTAAPSSMPEDRPTTEVEIVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STF1</accession>
    <name>A0A2G8STF1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STF1"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="208" mass="22931" checksum="D7A80AF25AEA09DC" modified="2018-01-31" version="1">MPEPLKDKVVDKVESKLDVLADKDVDSTDSELRYMAYGARLRTALRAGQRYIAYTSDVGEAFRPVVHPAVVTAAYGISWLYLAGDVGYETYKAHRRGPNALEAAHFSEPTRLSLIAVKRSVFQSIASMALPAFTIHTAVKQAKKAFANVQNPRVRTWGPTATGLAIVPVLPYLFDEPVEHVTDVAFEWVEKQLARSSESSQGPSKPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STK0</accession>
    <name>A0A2G8STK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STK0"/>
    <dbReference type="STRING" id="1077348.A0A2G8STK0"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="1">
        <location>
            <begin position="37"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="44032" checksum="5929ED5AADD43B70" modified="2018-01-31" version="1">MSDNTAPPYYDSTVEQLYNVANDVEMQDAFPTNQLFLYVVIDTNVLIDYCGIIEQFCQDAERAQYPIMIIIPGVVLGELDGLKNRPELQWFARQASTWLLKKVKERKTVKLQSAKETRSPGGARTESDEVRKNDLAIRDCCLFFADKNKGHGALLVTMDKNLNLECHKEGIDVCLPPNRNSWSSRLLAQALPVDGVNLELFHGREAFPRYRPSKTRQRLGQTEGPMAEAPHLAIADADMMDVDELEQDTSVTVEEYVPVHARDSLHAQIAGHFPLVLRDLAHRVHREYGDPLTVSNSKHAPAYRRTAVSSWTAALCFSYLETKKRFGREAWMGSFFCRRGEDGWRKGQDWSPRMWHLALDMLEDVGKKFDDGPLLSSVAAVRPHVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STL2</accession>
    <name>A0A2G8STL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STL2"/>
    <dbReference type="STRING" id="1077348.A0A2G8STL2"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="9"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL37116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="321" mass="35362" checksum="2B0F62D22D7A7A14" modified="2018-01-31" version="1">MDDPQPTRVDIHHHIFPTSIGKAALSMNVGWQTPAENLPWTPEVSLEAMDKLGIRLAVLSMPAGLPAGPVGHENRKSAREFNCLGSQISAGHPGRFAFFACMPNLFDIQGGLDEIKFALDELEACGVVLSSSYGEGPEARYIGDDAFDPIWEELDRRAAVVFLHGAQVPSSTPYPHPYLGIPVTEVPNETFKAAAHLVVSGKKRRFPNVKIILAHLGGVTPFLAPRVAVLSRHMGCPLSHEEILEDFKTFYYDTALSTHETTLAAMQAFISADRILFGSDFPAVSVEMVQWFSRNAEDFYASNDQQRDAVMHKNAEMLLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STL9</accession>
    <name>A0A2G8STL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STL9"/>
    <dbReference type="STRING" id="1077348.A0A2G8STL9"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="413"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="450" mass="50661" checksum="8D3B513F456AA22A" modified="2018-01-31" version="1">MAALRKVRRFMWGELPESKAERNLLLKIDWFILSYCCLMYFSNYNLMLQVVPPRIWLPTMQIVWGVLTFCTSAVTSVQQIFVIRFFQGIAESSTFVGTHYILGSWYKSGELGKRSGIFTSSGLMGTLFSGILQAAVYTNLNGRAGRSGWRWLFIIDGIITIPIALYGFAMFPDVPTTTKAFYLSEEERLLSCERLESDKDRDIGHGYLNWSLVKKLLGNWRWYGCSLLFAISGETESFGSNNLMGQWMKAIGGFTVPQIDNYPSGMTAFAITSTLVCATWTDATKSRARWPVLVYMCICTITASIILLVWHVPVGAKFFAWYLAGASYAGQATTFAWANQICADDHAARGVVLASMNMWNNVINAWWPLVFYPATDAPRFTKGMWAMIGTSIATLGVTWAAWYLERREKRMKARRDEAGDGEKRDVRGSQKVDEKTAGRSEEKSGNGRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STR0</accession>
    <name>A0A2G8STR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STR0"/>
    <dbReference type="STRING" id="1077348.A0A2G8STR0"/>
    <dbReference type="OrthoDB" id="3358904at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="16038" checksum="51592D832C6FDF1F" modified="2018-01-31" version="1">MSEPSAQEPAPEFSPATDYGSFAVDVLARMTRTSGRIDQMVLRRCLGLASSYLVSDVTMNAEEGVRSWRAGFNRLVDVMVALHMRQELEVETVNAASQACSECWSVAGSWREMDECREGVKAIATRLKGLLDANGKTFRGQAIYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUG6</accession>
    <name>A0A2G8SUG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUG6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUG6"/>
    <dbReference type="OrthoDB" id="2590590at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="762"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="819" mass="90513" checksum="1262A2169D3DFDEC" modified="2018-01-31" version="1">MSDPFNVPTVPEQDQSGGDGLPTYDDLAQQHGPNSRFGRWKEWIEKRAAERYNDLTPADLERRRQRGWGDGVDQQSNQAQARPPRDPSLPTLSVYAPSTYSSSDGSSPQPFSMYSSDPSSYAQSSYTSQPVSMYSNAPSSYNSLPISMYSNVASSYTFAQPPPHPQLQLQTSFLQGMPSPFSHATYPPPPQTLIPEPLEPSHLKLYNFGSRFLPHTTSPIRCLLPLNNHHLLLIGHDNGLSVLDMFPSDWNDDNETEKGPSDAEAKVVWEGEGVHQMTILESESTGEGTPQGVVLALVSTEDTSSSKDSESMKVLRMYNLGSLISLAKYYATQKGARPLDLRSSGKSSQSSGKKHHHHRPPSSITKGLKNLVLDNGIAQPQTPSRHPEPQASYSSITDSWASPSKSKGKAAETPLRADSTDSEWDVVNELPLRWATNYTPLASSGSRLQNCSVVLYDVWRNEGQRGPGGVLLAIGTKSSILLYEAPKGERAFRFTKEFYTPLPARNITFIHQSVQDSMSRSPSDVFPRTTPLDNVSHQRHMRVSSFGSNSRVYPTQLSLFVVFEKKAGTIRVADAAVGEVELYEDNWSAHQSMLMSTPAASPLTSRRSRGSWDGRGFAKEKGVWVRPVRFDVPGAIGRTAFTQMYLLTRGRQSHIIPHPLPARVSAVPPYRILYWTSTPTHISVRICDSDDLDEPPILQIMAFGEEGVEIQEVPLSQLSERKGKGRAQEPVRTQADVGGAAGLLVGGGNWDRPFFQGGLQRSYSTSSADTYGSSSTVDNEDRERRLRSREGVYGWVRRGGEDYRVVWLGGGNEEDDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVF4</accession>
    <name>A0A2G8SVF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_01443</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVF4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SVF4"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="63"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="723"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="484"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL37749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="816" mass="90790" checksum="C19F2BE96095C61A" modified="2018-01-31" version="1">MPSPSDLGCDSSGAANGTVPAPGNSGANALSAPDNILNSRYASARRELLELVRDLHALGHAKTLDVPQIAVIGKQSAGKSSLVEAVAGINVPRDAGTCTRCPMECTLLTSSDKWSCAISLRGDHINEAFSPEITSKADVELWIRRAQAAVLCPHLHMGRFKTMSHEEIKHATDHTVDPEVKRFSNTVVEVKILDPDGTDLVFVDLPGLIPNADDEIVKQVEDMVKDYISQPSTIILVTVPAEDDLENQKAMKLAKDADPRGERTIGVVTKADKIQPGETGRQKAWRDIFEGSAREHKLSLGYYAVRLPTDEERARKITPAQARDQAARVFDTVVPWKDVKAFPGPTRLGVEALIRDLSPLLLNMLIAAIPRLKAAVDQLLAACLADLARIPARAKMDGATELVLLVLRFCEAVEQTVDGTSGDKSFVHGSRTHYRALKGAIRCTAPDFRPFENPAEYYMPPAPGSQQREDVFVDLPLVPPLPRSQQHKDHFPDLPSVPPLSPPSEAASECSRSASPAPSVEFVLDGSVPGNEGVVMGLLDVRQVIKESTGWELPHNIPYLAKTRLIREFVQRWAEPSKTCFASIRRLVEKYVYETLIPRHFEQFPSLGRFVTERLRENMAGYLDRCETAVQQALEREEIPYFTQNGHYLEVTRELWLGHYKEVRAQRDKYRRSSTFASTTSYLNYSSRAVTEALAAIRMLQGYSNITATDLPKLLPADEYIDELGVMADVRSYFQVAYKRVIDNVPHTIHHAFVQGFAQGLRPYLLGKLDIGGEDAPQRLEKLLEEDPEVLRARKELEDRRTRLEDIKARLNIFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLE4</accession>
    <name>A0A2G8RLE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLE4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLE4"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="378" mass="41892" checksum="C45C8627D50187BC" modified="2018-01-31" version="1">MEQNGDSEVHRVWSLLSEVSEQLSQNRSSAVNLHALADGAKTQVIHSQTGFVLRRFNLDKPKEAYDAELERMNAAMSAENQALLNDNRQLSALIREYEQTLENVMTTFRTRAHEVQQRELTLMRQYESVLVQRESEALDEALNVNNARSESLARVGRLLRAVLRRLGGEDIQVYEAHLTHLHATTGGQSAGNPREPSKLVSHPEHAAEREGDEGESGGEVGKAKGADGGAHESDEQSPDQDQEENLDVNRLLEEDEDPEKRLAAAEWALERECELARLERENEELRALVNGLLKPPAAPTATTSTAAPQRPPESTSTTAPIPIPEHPIGEDEEDRSSDEHSSFSTFPRPQQRLLGGPPGTVGPFGTYKKNTLIRVDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLZ4</accession>
    <name>A0A2G8RLZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL29m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">54S ribosomal protein L4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_15225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLZ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLZ4"/>
    <dbReference type="OrthoDB" id="270763at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038340">
        <property type="entry name" value="MRP-L47_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010729">
        <property type="entry name" value="Ribosomal_uL29_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183:SF18">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21183">
        <property type="entry name" value="RIBOSOMAL PROTEIN L47, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06984">
        <property type="entry name" value="MRP-L47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL22536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="235" mass="26770" checksum="49C2B2C23039C0C6" modified="2018-01-31" version="1">MLSVPAVASRAARSVATFSLHLHSRRLATQVPAKTGSSSSQTTSEDGSLRPHLQIPVNPNHGLYAFFRRKEIDGKTFYDTVESADMTGDKSGRSWTAAELRRKSFKDLHTLWYVVLRERNLLATQQAEARRLGANEQALGLWAKSFRCRKTMARIKYVINERRVAYEGALKIFNKRHEKLLRNQKPAPVVRLSEEEEARLAQRALSQEKSMRQQAHIDDIVTRSFLEPEVAQQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM37</accession>
    <name>A0A2G8RM37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM37"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM37"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051340">
        <property type="entry name" value="Haloalkane_dehalogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42977">
        <property type="entry name" value="HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="35"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="296" mass="33578" checksum="49EE4BC6F2D9589A" modified="2018-01-31" version="1">MASSTQVKTITVDNGVEVFYREAVPTSGKDISSLPVILLLHGFPSSSFQFRNLIPILATKYRVLAPDLPGYGFTAVPEERRYQYTFESITNTIAAFLDALRIKEFSVYIFDYGAPTALRLALQRPKAIKAIISQNGNAYEEGLGKDFWAPVKKAWEDPSKENFAALEKVTSLPITKWQYENGSPNRSAIPPETYHLDYYLMTRSGNAKIQLDLLMDYRNNVKLYPEFQKYLREFKPPLLAVWGKNDVIFVPPGAEAFKRDNPNATVKFVDDGHFPLESAVAEIGHDILRFLEKQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMT3</accession>
    <name>A0A2G8RMT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_15308</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMT3"/>
    <dbReference type="OrthoDB" id="3354157at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL22618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="43397" checksum="AB44CF41AD719C93" modified="2018-01-31" version="1">MKEAAESIIQEVAELRITAYVGLASYTVLVYDHLLTLDDEIKYIWKKKKGSPLIWLFFLNRYMTPLAFIGNLCAYLSGTFTYEKCTHYVRYEGATTMIGINIASLMMLLRIYAMYETQKFIVAFVAIIFCLEFGTNAWLLSHGIAVHHSPQVKACSMIFDSSRLPGVAASATAWTVLVYDTIVLLLTIFKTYSSLRYKTVAGTMRTLLKEGVAYYSVIFSVTLVLTLMIAFAPPGIQNLCAQMEYLLTVTMMSRITLHLKRAAHLQEIRESTLRASTMTTAQWRPGSDVHFARLGPAGYTGCTTQNMPYTPLNITVSEQTVTHNDNGEEGCLSHKSMSGPPLSYVGTSSPMGSKSDGREEWHEFSQLRSKGEKDLPLVPDRTVDLDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN36</accession>
    <name>A0A2G8RN36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN36"/>
    <dbReference type="OrthoDB" id="2734101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013688172" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="15221" checksum="56EA746381C1CFD4" modified="2018-01-31" version="1">MKFALALIAFAASALAQHIEIGTPNNFAEVKAGSKITVEVNRPNSLTASTEVGIAIGLWPCGGPKGTSKCASTDVSQVLGNVVYTGSYKAEYDSAQPSKPPHQTFEVTVPTSFSKGEVSLGVAHLFLMGAGSEPVYEFVNTTLVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP01</accession>
    <name>A0A2G8RP01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP01"/>
    <dbReference type="OrthoDB" id="2804474at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="598" mass="68537" checksum="189021CA6FCAF5A7" modified="2018-01-31" version="1">MEREPHSVQDDHVPRELVFLYPRKPDPYDAAHESERSFFILRPGSDVPPKYPEKTSPPTPYDLVVGFLAKHGQTELLSTLAFVNRNWCRAVRKLRFRCLHLEPSLDFPRLLEVFRPNTVLPFLRQLHLNGRLTSGPRSARDPEHRWLAPLVPLFAHILAAAPVDYLFLQSLSWGNVPAEVRAALLGLPGVRALGIHDVDFWNSNQFLRVLNAHAPRLQFLQIWHATYWAYNHVPSQLQHTEPLLLTELVLGCAYTPLIMEWLLGGGQREVLAIEELDVASRDVYRDDARLARVVKKVAPWLKRFSYNEWGALNGMCEGTNGGDDEEPESDEEMEVDEDDDEYEDGDSDMDEDETGDTDGEEDSGMDEETSERIGDDEDQVTVPGNRTDSAVAGLPRMVEVSNTLLLPDDEENSRMEDGDTEFRNPPFTRKGSDLGRAAFAQELEVINNPDSPMEMPMVESVDGRIYWKSSFNFLTLAMLCRPVYSSEGFYRFDLSISFESVDVFDDAPWRDIDRLLLGITVPERDDNHEDDEDDEITFQVVIAVKGWDLRGKQAKERLKEIRRKLPRTVKKNALRIYVETWSRSPPRPGPREWIKTYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP49</accession>
    <name>A0A2G8RP49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP49"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP49"/>
    <dbReference type="OrthoDB" id="2687488at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="406"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="448"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="492"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="633"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="724" mass="79542" checksum="BF2351B8E404EEE3" modified="2018-01-31" version="1">MHSSPPTVNGLQLILKHHLAVHYMVPIEIFEAVIDQASDDTTSLRHLSLACHAFLSRARYHLFSAVVLQTVQRVQAYSEFLGSHPWAGPLVRKLVHSSFIPMSPSHPTARMLDAIPLHLLSYLPNLITWEIGMAGIKSRSEVGAWLSCRDTTLSNYRGLSCNVRNMELAYVHFEDVSDFVELVSAFPAVQNVTCSYITIKSSMEAAQHGSETNRCDRSMQIKSLRVTTTVDIRAIQYLLDSSRTTVDNFSFTFQSLQSDEYFGRLETLVRPLSQLSSLGFVIPSGGISWDDDVGEGFLRDIGFATRIIKTVNSVGAQAMRVDFNPDPVASLGCRLSSGPQSLDVCAALEEALLTFPRPRVLAHDAVYARRTGRVEFWSATIKRAFPRLSERGFISFPESHSGTPDTAGHEATVKCLTASLDGRRVVTASNDGTIIVWNPEGGTASQEWFAHRRGVRALALSPDSQRLVSTGGRDDTLTVWDVSNGVRQAGVIEGHTESVTSCAWSPNGALIGSASADGTVRVWDAQTFEQRDLFEYPWPVDFLEHLRFSPDSRFLSWANRPLRKRGCMIWSPLSGEPAKGLFSESIGDGVHVNALSFDSESRRIAVAYAHGRAHTENVVRLWDVATGALLAQMAGHEMMLMDVSFSPDGRSVLSTSCDATAKIWDAEDGREIACLDILEFSMPAARFSPDGRYVATTSWGGAVQLWRTDDGSSVMGSNLVTVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP93</accession>
    <name>A0A2G8RP93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP93"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP93"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="527"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="850" mass="94660" checksum="60CAA5592A3C2FCD" modified="2018-01-31" version="1">MAQHPTLSWEAMQDGSVFYRRHQLYTIPGKLPGDLQDFIVAGCRYGGPVALMRDTSKLVAINTAAPTFSKAQISIYSPAGEGILLFSWDQGKIIRFGWTGDERLVVLNEEGVYRIYDLQGEYQQYSLGSEAGELGIIDARIHETGLVALTGSLTFLEVKEWSGGKPLTLANPGLSHPPQSWTVIPPDQTISRHVEVLLSVESTIYSVDNLENLDQRISRGPFTHMSPSPNGKSLALLTYSGLLWVVSTDFQRSLAEFDTTGVVGASGNVHQVEWCGNDAVLVTWRGVAVLVGPFGDTLQYFYPGSMFATTEPDGIRIIGPDTCDFVQKVPVSSASVFRPGSTSPSAILFDAWENFSRRSPKADESIRSIRPELAAAVDECIDAAAREWEPVWQRRLLNAAKFGRSFLDLYDPSDFIQVGQALKVLNAARFYEIGIPLSYAQYTQLSPTHLVSRLLARNLHLLALRISSYLALPPDAVLKHWACAKIVRSKPQASGTGKNAELDGGDDALCRVIVDKFETLGRGRAGVSYADIAKRAWEVGRTALATRLLDYETKASDQVPLLLSMQEDKLALAKAVESGDTDLVYHVLLHLQKRLSLGSFFRLIEDGGPRLALASRLLQVYAREQNRDMLRDFYYSDDRRVESAVLCMDDASLALDPTAKLTSIKAAQKFFSEDKDRSFEAKMMDESARLMTVQLTLEKEADGKITFFGQSVNETIRTCLINGMVKRADKIKSDFKVPDKRFWYLKLHALTSIRDFEGLEAFTKSRRNPIGFEAFVKHLVDKGYQKEALSYVPRCDGPKRADLYVLCNDWRAAAKECKDRNDKMKLEQLRKSAPNSLVARELEQVVASMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPP1</accession>
    <name>A0A2G8RPP1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_14791</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RPP1"/>
    <dbReference type="OrthoDB" id="2446696at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="308"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="842"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="17">
        <location>
            <begin position="1142"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1244"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1287"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1244"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1342"/>
            <end position="1354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL23480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1379" mass="156557" checksum="F9F11C9493BBC03E" modified="2018-01-31" version="1">MSNAGTTPAPPQLPAGYDVSKLVTQLAPREYDGKMAQDGLRFVSAASIYHSNITTFSPSFPETILWITLLNKLTEGAAEWAGPHIVTLASGTQPWADFAAFETAFKAHFCAADDKEAAIAELVKLCKGQHKIGTVQDYTVKFNAIAARTSFSAEDKRERYRTGLPYKIKDILATSGHDTSSITKIQAVALTMDQNLLVREEERPKQFSGGWRKKGEKAAATATYTYSQQLAEQEYQKKEIRPVEEIVPKQYHEYLRVFSKEASECLPDHGPYDHAIELVPDARMFHSKVYPLSPSEQVELDKFINENLAKGYIQESKSPMSSPFFFVKKKDGSLRPVQDYQQLNDITIKNRYLLPLVSDLMDRLKKAKYFTKLDIRWGYNNVRIKTGDEWKAAFVTNRGLFEPNVMFFGLANSPSTFSALMNDIFKDLIILGKVTIYLDDLLIFTNDIEEHRTLVREVLKRLAERDLFCKPEKCEFEQPKVEYLGNASDVRKFRGFANFYRRFIKDFSAVCKPLDRLTGNAPWKWEAEEQEAFDELKRRFTESPVLSMYDPDCKTRIEVDASGYATGAVLSQEGEDGKWHPVAFHSESMSDAERNYEIYDKEMLAIIRALQAWRHYLEGLPSVFEIQSDHKNLEYWKTAQNLTRRQARWALYLSRFEFVILHKPGTSNGRADALSRRPDHQTDDADDNLDRVLLQPDRFRVLAAKRGHMSVVPEKALLRRIRECGEREQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGRVYVPKDDALRAEIVRIHHDLPPAGHPGQAKTVELVTRNYWWPGMVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNALQLIADRHGKIIHLIPCTEEIDAEGTADNFIREWFRLHGLPRKIISDRGPQFSSKLFRAVLKGLGIESAMSTAYHPQTDGQSERWNQEIEAYLRMYCSRHRDDWVKWLPIAEFAFNSHVHSATGYSPFYLMYGFEPQFHIPMLSTAVPSADERREELRQAREDATSALTLAAERMKEYYDRYVRDAPEFKDGQKVWLDTRNFRAPGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESRRYGRWKKLQYLVHWMGWGPEHDSWEDAADLANAPKVVQKFHSTHPDAPSPLNKKTKSLTVEPCSALAAQVLVDALARLPSRNTADILVLRQTQGDPTDYSSPTIDLSSRPPPTLKRLTYVDSDSDDDGPVKCQKLEEDVGEGSGSTANAHVNDEFSKSGPIGDGQEDITEAVGRSSDALASSVHHGHEVADGDEVGNPEDEIVEVTTQEGEKLSTRSAKSNRQGRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPV2</accession>
    <name>A0A2G8RPV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_14853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPV2"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="48"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL23540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="250" mass="26927" checksum="321C2CB8656196F3" modified="2018-01-31" version="1">MQAHNPRHGIHTYHSHKQRVLGNPAAQPAPAWRANAKAASGSGPELGSKILLSRLPTDVVENEVEVLFSRTVGPVKEVLMVYNSQGKSRGMAVVAFARPGDAAVARAKYNGKIVDGRRPIKIEIVSDEDTPRSSVPAVVALPGQPSLLARLAKPTPAQAAAAASAPPQNGRKVLAQVQVAAVAPVMPSPRNRVRQKRGAGRLKKQRAQQGQQPQTQHRKQKSKTREELDAEMEDYRANGPSIKISESILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQK9</accession>
    <name>A0A2G8RQK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQK9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQK9"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="2">
        <location>
            <begin position="75"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="447" mass="49983" checksum="DE5BBA9AFB0D17E6" modified="2018-01-31" version="1">MDDWKLADLECLSTAQKQAFAKASILTASNLLVRRVPEVAKKCKIPVAEMEDLIDLVCQELYQSPRTIRTVDRIGEEVFTTGERYLDETLGGGIRTGMVWEIAGEKNAGKTQLALQLSLTVQLPPEEGGLYGAAYYISTRDQPQVLERLQQIIDHHPRLSPYSCTLPQHYTVSSFPLFRDMLHDNIPKYAEELYASTPGRKRLKLLVIDAVSDFFDADREPKYEDIVFRARHLRLAGSLLHQFASEFQVAVVMLAGTRATHPRVDGQDKSPGELRYSDQARWFSRGYSLDGEDANEAILGHVWPNQLNARITMSRTTRERPRNALDPEARRLRVPHEQSAGQALDDEKLPLRRFSVLFSSAAPAASCDYAILDGGVIAFPAEGQERPQSTPEEWPATLPPSTLSFSLEREGSQWALRASLSISESSAEPAAPPSPWYQQSLSYATNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRH2</accession>
    <name>A0A2G8RRH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRH2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRH2"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="478"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="121"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="675"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="850"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="859" mass="93946" checksum="D39E1AB30122E7C4" modified="2018-01-31" version="1">MSPMTVHVMAAVPRRPTRLVEPAAKVTPMSKLKAFFDDVINVSAPRADEVEESSTAPIRRPRIIYVKDYPTLAASSSVWYPALLASVRQRRQGPISRPSSPVLNPTVIVFGVSPSYVVPEAPPHPPPNVQLMSSSARSPASASASASASAKLQNEYGEDVSSEKAREKRTQRRLRRWARGNSDDLPRLFSASEESSEGNDPKGRPNVVVLGQEGFSGLPPFLGSAFSRALAGRNHGSPESDSRLGFFRTVLVCPTLRNIPQERDVRMARRREINQLVMRMGVAQVGGELGELEEVPDAVEELSEGDEQDKTRLQLWEHWGDTVEVWPNVQRIADRAVGSVMAASQAYLPTNRSLEPTLVPWSAVFDAWAADRSTQDMWKNLFTFPPSGKLPRENEEGERTGADEEADVDEIIEKLRRNPDLEEHEQRLLGCIVDTASITTTFNQVHLPPHTIDSIRTMVSLPLLHPGAFQHGILKEHSMTGCLLFGPPGTGKTLVVRALAKEAGCRMLVVSPSDIMDMYVGEGEKLVRAVFSLARRLSPCVVFIDELDALFGARLSRESGNSLAHRGVITEFMQEMDGLKTNKENNVIVIGATNRPFDLDDAVLRRLPRRLLVDLPGEKEREEILKILLRDEALAVDVDLKQLAKKTDSFSGSDLKHLCVSAALDAVKERVTVPWRPSASSSASSPASGEAKPGEDNIKQAPTSRLAPEQHGSFGERKETTPAREDPAQQDEPAATATSASNPDSASASSQDNPSATAEVPHPRSLAWRNFEQALKEITPSASESLGSLAELRKWNEEFGEGRKTKKNQVWGKGRFGFTLPVLEEAGIKLEPGVATPTPATTMPMPTPNAAHSTTSSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS40</accession>
    <name>A0A2G8RS40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MCM7</name>
        <name evidence="14" type="ORF">GSI_14075</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS40"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS40"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="350"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="699"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="721"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL24322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="782" mass="88036" checksum="9F6EB7E92AB9D452" modified="2018-01-31" version="1">MSLPVVTIDLTTPPDRIKQFLSQFASKDLVDGMADIGLQDGDDVLPRPKTLKYMQQLQRIANREQEMLVIDLEDISEHERTVAELVSRIRRNARRYISLFSEVIDSIMPLPTRDISEHDDVIDIILHQRREHNNNAEAGQQLIPEHLLRRYNLYFQPLRSDIAMVVRDVKGAHLGRLITVRGIVTRVSEVKPLLRVNAYTCDSCGSETFQDITRKDFQPIFDCQNEDGCKKNGIHGTLHMQTRACRFTPFQEVKIQEMADQVPVGHIPRSMTIHVHGSLTRQMNPGDIVHLGGIFLPIPYTGYQAIRAGLLTDTFLEANHIHQLKKQYREMELTPNVMREIDTLSTDPELYSKLAQSIAPEIYGHLDVKKALLLLLVGGVTKALGDGLKIRGDLNICLMGDPGVAKSQLLKYISKVAPRGVYTTGRGSSGVGLTAAVMRDPVTDEMVLEGGALVLADNGICCIDEFDKMEESDRTAIHEVMEQQTISISKAGISTTLNARTSILAAANPLYGRYNPKISPVENINLPAALLSRFDLLFLILDKPTREDDEQLAMHVTHVHMHNTHPALDFEVLDPTLIRHYIARARQHRPTVPAEVSEYVVNSYVRLRKEAKDEDAQKKSHTYTSARTLLGVLRLSQALARLRFADSVMQADVNEALRLMEVSKKSLADDDEEGHDHDRSDVSKIFRLIKEMAKQAQVGRKGRRARGARRFGRGPGGERDMDVDEDEEEADAEELSMIDIRSRVLTAGFTEAQLMETVLEYEGLDVWTRVANNTKLRFIETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSS1</accession>
    <name>A0A2G8RSS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSS1"/>
    <dbReference type="OrthoDB" id="2755409at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="337" mass="36684" checksum="353C5F0FA65630A4" modified="2018-01-31" version="1">MANPPPPEPPTDGVSALHIGAPVDAAAAPSSHGSPSDPLPPPTTPPAAQPKFPQHHPYEFKSTPLRPSKNDLDIAQKVGRDRRLGLVDDTGMGSRFHQLGIHTFNALLQGSPPTAEDREKFVSPKITSEGMSERAIGIELSKTIRSVLDAAGTGGLRVLHTPSHKAKGDHTTTMPPSAASSAAAIIAEYSTLTNVNYCGLAGFALILHDYLVTFRQEVNMFWTRKLNGAAILFYLNRYAFITVYAIYQLTTYAPISDERCDMPTLSYAVWALFAGLRAYALSWNWPLGLFVLLLQCVPIGINLSLFHFGVMGIPLPRIGCELNDFVTKTLSRRIGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSW2</accession>
    <name>A0A2G8RSW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSW2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSW2"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF2">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33020" checksum="6527740DD01E8ED2" modified="2018-01-31" version="1">MSVSAEPGSLSSKTDVLQTSSKESSITAMNFCRLFSRPRTILSRNHLMSSVDPHRCSFPLIALCFMTGLIDAVSYSTVFVWAGFQTGNTVQLSIALARLLERPTNFQLSDQHALTSLTCFLGGSFLGRVGNHLGDTTRAWLVLGTFVQTLFTMAAALTAWQSGQASVSPSAASVAQAPWTDATTFVALGFMSASMGLQAIMGKRMNTEYATTVVLTTVYSELVAQKDLFTLRRRVTSRDHRALSIVLLFFGGFSGRAIVQTAGAPTALGVGAGIRLIITLWWLFVPGKEQGKPPGQGRSSSEADTECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT47</accession>
    <name>A0A2G8RT47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_14274</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT47"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT47"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="16"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL24518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="571" mass="61161" checksum="E69DE7FF437AB0C4" modified="2018-01-31" version="1">MSDTTSAHVDNPSVSAHTPGNLPQPVSLLLHDSTIDAASEICEGLALLQHRGQDACGIVTCGPKGRFYQCKANGMVRDVFDASAISRLIGGMGVGHVRYPTAGSSNHAEAQPFYVNSPYGIVMAHNGNLINTPSLLHFMDAVAHRHINTTSDSELLLNIFADNLQKTGKFRINEEDIFTAIGGLMSQVKGAYACVAMLAGFGIIAFRDPNGIRPLGMGSRKALGGGAGKDWLFASESVVADASSFSEWEDVRPGEAIIITRSGVSRRQVSPPATFSPDIFEYVYFARPDSVLDGISVYRSRMAMGDALADEVQRVLSAHNLAVDVVIPVPDTSRVAALNLAQKLGLPYREGFIKNRYVGRTFIMPGQQMRRKNVRRKLNAMALEFAGKSVLIVDDSIVRGTTSKEIVQMAKDVGAKRVIVASCAPPIRHVNVYGIDMPSRSELVAYQRSEDAIAQAIGADLVIFQTLPDLIASVRQFNPAIPQFDCSVFTGEYVTGGVDEEYLAGLEQLRADNVKNLMEVGGLGTMEGKGGGAARHEPNGSIESREIAVGCSGPMNGADSTVGLHNSYSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTA8</accession>
    <name>A0A2G8RTA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTA8"/>
    <dbReference type="OrthoDB" id="10616408at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="143" mass="15732" checksum="C354373A7E42BB46" modified="2018-01-31" version="1">MPTRAPRSHVPGGRRAFRATHPLPNLSLCLRLPPSSLAWSPDPSRDVPRSHPTLPVRDAPGFPNNWCGCRAEHLPSCTPVMLRAAHAGEHSPVLALALVRRWLRRSVPWQHLLPLTLPARLPHLRIPSISGPRGGALCARMHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTP2</accession>
    <name>A0A2G8RTP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTP2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="102" mass="10305" checksum="F03C764273014D11" modified="2018-01-31" version="1">MSIWSLSGSYPGRGVRSVESGGSRFEPRETCAASSGVGEPLSCPAPTAPAILRPTSPPRVGPGPVLGPREGKPPESGLGLGADTDNEFIECGGGRVMLLCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTV0</accession>
    <name>A0A2G8RTV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alginate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12817</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTV0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTV0"/>
    <dbReference type="OrthoDB" id="526316at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008397">
        <property type="entry name" value="Alginate_lyase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05426">
        <property type="entry name" value="Alginate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013768935" description="Alginate lyase domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate lyase" evidence="4">
        <location>
            <begin position="84"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="390" mass="42597" checksum="6A8C0578B899F964" modified="2018-01-31" version="1">MKPSRFLAFVSSALSISVVPAAFVHPGLLHTAADLTRVARQVNAGVEPWLTGWNKLVNSTYAQSSYTPRPVQLLCRGTPASCTQNYPNIYRDAAAAYALAVRWRVTGDPAYGTAAANVLNAWSATLTEISGNSDKYLASGLYGYQLANAAEILRDYEGFTVANMTALVDLLVDVFYPMNHRFLVEHNDAKVDHYWANWDLCNLATMMSTGVISDNQTMFNEALDYFYNGAGNGAIDKTIWTLYDDGTGQLQESGRDQGHSMLDVALLGVIAQTAYNQGVNLFAYQNSRILAGAEYAAKYNLGNDVQFTTYVNSDVTQTVISNNSRGNVRPIWDLLYNHYVKIDGLEATYTTQYADLVRNDGGGADGGGGYYGTTSGGFDQLGYNTLMFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTW0</accession>
    <name>A0A2G8RTW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_12826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTW0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTW0"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="75" mass="8121" checksum="5C6C1ADBA06AF0F6" modified="2018-01-31" version="1">MSTREADRISAAEETLNTLFDISQLLNTGLDKETLATCVSLIESGVNPEALAAVIQELRRESAALRNTRTSSNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV20</accession>
    <name>A0A2G8RV20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_13252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV20"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV20"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL25362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="267" mass="29158" checksum="430E50049B49DBC3" modified="2018-01-31" version="1">MQPYYYDDRSHPPNGQQPSYTAGGWIDGRPAQQYAVDPRMYSDARAAASTQHPGNPYGTTMSAAYPTSLPQGSYPNPNAHALYPGARAYTQHPQTAQWHGQGTTASTHDPYSVQHTSLNANPGSAPVFLYPPSHTGSPTAYPGSSAAHPAYTYPDDTDDPPGRDAHSGAREWSQHFTLQGAPRERIAIACDRCRARKMKCDGALPACSNCQRAAHQGVECHYEPEPGRRGPDQAQRVRSAPGQRKARKSGARRERDESPPESSGYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVN9</accession>
    <name>A0A2G8RVN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVN9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVN9"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="152" mass="16596" checksum="6E05B80F9DCB4C2E" modified="2018-01-31" version="1">MSSSVSDASSPGPSTAALTIPAALLMHQLFRRYETFSVLTHAALLLGPPALIAASAVSDPSMNPESFKNAFRSSVLIYLATLAISIVVYRISPFHPLARYPGPWLAKVSMLTPALYSTTGRRNRAVKRMHELHGDVLRIGPNELSIAIRRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVQ0</accession>
    <name>A0A2G8RVQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVQ0"/>
    <dbReference type="OrthoDB" id="2749026at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="23"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="275"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="685" mass="76532" checksum="5101DE23D0285C38" modified="2018-01-31" version="1">MRLLDLETGDFAEFSSPSTTPPYAILSHRWDKTEQTYQDIKEIQRVCEENRRPAPPPRARSWFPTRFSSPHNGVSDSLPPPPALPQSIWDSSVLSDKVRNACKVAREDGFRYLWIDSCCIDKTSSSELSESINSMFAWYRDAKVCYTFLVDVPTSSFASLNATGSAFRSSVWFTRGWTLQELIAPRQLVFLSKTWEPLGTKASLSALIKEITGIPTSVLARDSQDLSHRSLDQCSVAQRMSWAANRTTAKVEDEAYSLLGIFDIQMPLLYGEGRRAFRRLQEEILRRIPDQTIFAWGNVHPVCFSPQAANPSPGPIRNVFRAGPSSAASGSRTMFAESPGDFAGAGRIVTVRLHVFRELLAAFCDISPQEYTSTPHGIRTDFPLLPLSDSGCPISVLDKHRATDVYLAILACQQSDSPGQLLCCVCHLPRPDAFMSTLCRGYLTDASFRTLSPVNTAESYAVFRLSLPSSDGQGHGKPELNLRLHTVYLDHPKRAPPPLDLENHLGKDSVLEDVTFTLPTWCRGALHTRGYDAMLHQQPISESEEDRAQVHRLIVSPLPVPQTSKLEAGHSFQWNIVADFSCECDDDSILDTEIIRASVHIVGWGERVYDEPEGTSSRAPRTDVIKTATLEWIHQRRGPPGRMVNGIELWREGRKSVALLLGVEVASAYSYRIHVEFVDQDLNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW29</accession>
    <name>A0A2G8RW29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW29"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="130" mass="14885" checksum="BA0B5780522B5894" modified="2018-01-31" version="1">MSRSSISLVSWKTEDPPQRYLLDTYVNHAQEQEVFIWKHKGYMQSKGSRGVHIQAFLPDHGLWRDLDNIPDGILRISPFATTLIVRYDDISFCDAFSEALSKAERPYNKHGVEWPTETPRSEIAVYGAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWG5</accession>
    <name>A0A2G8RWG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinol-cytochrome C reductase hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_11418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWG5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWG5"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013627729" description="Ubiquinol-cytochrome C reductase hinge domain-containing protein" evidence="10">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="11">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="109" mass="12213" checksum="5ADAC30768DB699D" modified="2018-01-31" version="1">MSLSSLFSSFFQTVHADAPEEKEAPQEEPAEEPQAEEEEEEPEDILPALTEECTESAKCAPAAKHFAHCEEKVNAGQGFKGEDCVEEFWLRRTKTVRQAQVEEALAYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWH7</accession>
    <name>A0A2G8RWH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWH7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWH7"/>
    <dbReference type="OrthoDB" id="2741110at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="80481" checksum="464CF34C2DA8BC15" modified="2018-01-31" version="1">MDNIEDSRLQSRHPSLSTEIEENVIDYVYSVDDITTLLNCALTCRDWLPRSRIHLFSAIRLSTREDMYSFCDFLDTHLEFPMLIRSIIMAPNVFEKKPACLLETFPVQLLSRLPRLRGWALRNDLASDRERNISHHPIILRNLRRSSPVVDLDLESLKFASLTVFLRFITSFVQLRHLRCNAIRFDQKGGLKPYGIGGLNLTTLQVGGIPGGALCTLLDRTACTLESLGIASQQDVDGVSAMLSRMSNLRSLTWDIQHEMDWDRITEALSGTPTVPTFMSFRANIFNLDDLWCLKYYGGKELVFTFLEMKLQSFTINVCAKKVHPLSTTIRSMTMFAKFSDEGLYPQLIFTGATFLDELYRPKRIAISPNLQRVAATAQGLDGGILLWNISDGISVRSWHIVCPMVVDPAVVSPQVVFSPENERVLIVGVQGYAYVQDLKWQCRMASIRCAYSLFAAWSPHCIVFLTRTGTICTWDPATYRPIQDYDVFEPLGGVTAEQCRGALLFSPDNHWLAAHFNAQNGLATWILFRVVPDCGGGAKLINPHSLKELSSLAGSAKESPDFRFGEVAFDLESTRMAVLDRLVKVHIWDIAQATPIHALIVDMSTTLAGSQFNNQSLKWPVLPTKLAFSGDGRNLLFLHLKGDDSQKKVQLEVCCAKTGHLRNPLGMQGILGSGPPVRISCDSDAYQFSSCGRYLVASPETGGIIVWRTSDGSLVRRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWK6</accession>
    <name>A0A2G8RWK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWK6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="161" mass="16174" checksum="9B7D883A4B4E8E38" modified="2018-01-31" version="1">MGVSSIGDVAGEGMGAPTVSVGTADCCARAMILASVDWLACGGGTGAGSEAAGAPKPFETSACSSPWIPSTMFCAWWMTAGSTSPSSGPMCSARVGATEDAAIPFQSFARRLISSSPSILSTSTSSISAYAHAASTAESASLDRPFPLRSRRRGRARPCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWN6</accession>
    <name>A0A2G8RWN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_11478</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2,3-saturated acyl-CoA + O2 = a (2E)-enoyl-CoA + H2O2</text>
            <dbReference type="Rhea" id="RHEA:38959"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.3.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; peroxisomal fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWN6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWN6"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000003">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="16">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="17">
        <location>
            <begin position="282"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="15">
        <location>
            <begin position="525"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL25728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="678" mass="73465" checksum="FCE13E29DD0BFB32" modified="2018-01-31" version="1">MANLSQNQNVVDMKRARQLSTVDPKKLSIFLWGETEWEARQRILSILSNDPIFDKSRRPFLTRTQLYTRGLAMMSRIHELTEQHQWSSDDVALAFKILDEPLPIQLHMAAFEPVLKSQGSRELHAKYAALVAHRGILGCYLQTELAHGTNVAALETTATYLPATREFELHTPTPTAAKWWIGALGRTATHGVVQARLVLPSGRDAGPHLFFVQLRSLEDHRTLPGITIGDIGPKAMGGYAAVDNGFARFERVRIPKEQMLSAFAGVTDEGEYVRPPHAKLSYGGMLYIRSSMVSSAGWTIARAATIAIRYATVRRQGTRREDGLEQQVITYPSVYHRLLPILGRAYVFILLGRNLSTAFTALLARLSTGDTSLLPAMHATTAGLKVLASTTAIADLETARRSMGGHGFSAFAGVGRLYADYVPAATYEGDNFVLDTQVVRAALKAFARVASSAPAPGAVGEFAPNEAYLRRLADGGAGNAGSGNSVSTDSWGNPRSVVALLERRAACMVRERAAHAADPDASMDQRVARAVTDAFVAAQVGEVIDGLEGSVGGKEAAVLRKLYALHLLTTVESGLADVLSFGLLGEAGPAEDPSRGLRVAIKRLCEELLPEAIGLSDGFGFSDWELDSALGVYDGNAYETLYKMAQLEPLNESEAPEGYEKYIKPMLERGQRLAGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX04</accession>
    <name>A0A2G8RX04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX04"/>
    <dbReference type="OrthoDB" id="2744591at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61387" checksum="A18F13EFFCA7BC44" modified="2018-01-31" version="1">MSGCQFPSPVLSVQLERSTSSALKAQPSISCLGTFASSSFVVSPQDAHTVAAFFRMDTRPRLPHDVLLNVASFADRKSILALLTTTRSLHSDGGKYVVQDPVTLDGNQDIVSFIYFMRPYKHKRWRHLRFLHLRDAPISPGVAKALAKAIPRASHLSYLEFEDAEKTLGAHPDLPLAFAALRAVKDIVIDHGYHHTCRMLEAMKWPLESAELKHSDHEFDRDCRHRIHPAALLKNSQATLKTLECSLWSDFDDVLDTYPVYPHLESLHVEIWCPSVAHWAVSYPNLKRLHVNTLDDLFMKEANEDQLDRYAAIRSHNLEEHMAQEQQWVELDEFDGHTALDLYLLGLPCRVRAVSFALCPSSLRFFAPAMETARPTALTVFITSELFSQPVPTYLEDPGLVDVKALGIDVQVWAGGTAGDVDVTHVDRFLEHVLRLLQQASAQRFSLCLEVERLDDPPLSDYDTDDQDERRLRPPAPPRAVSPIETWINGTDLGALVRRFHDEVPSLDWVQFSVKAPFISCRKEAESSGRLAPEEQLLDTSLPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXH3</accession>
    <name>A0A2G8RXH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_11957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXH3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXH3"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="691"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL26202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="730" mass="80152" checksum="9F183799EF6F8893" modified="2018-01-31" version="1">MSSFRAPPRKGENFELAADLNSEYKEKRKDAIKRVIANMTVQKDVSGLFPDVLKNMQTDDLEQKKLVYLYLMNYAKTQPELVILAVNTFVKDTDDPNPLVRALAIRTMGCLRAEKIIDYLCDPLQKCLKDDNPYVRKTAALCVAKLYDLKPELVIENGFLEQLRDMIADSNPMVVANTVAALSDIHLAAVAAGVPRDQFPITTDIVNKLLVALNECSEWGRVAILNALSRYTAEDAGESEHICERVVPQFQHANASVVLSAIKVVMIHMREINSENLVKTLVRKMAPPLVTLLSNPPEVQWVALRNINLLLQKRPDMLSNEMRVFFCKYNDPLYVKVEKLDIMVRLASDNNVDPLLSELKEYAQEVDVDFVRRSIKAIGQTAIKIDEAAERCVNVLLELIGTRVSYVVQEAVVVMKDIFRKYPSTYEGVIPTLCANLDELDEPEAKASLIWIIGEYARKIDNADELLGIFVDTFTEESYPVQLQTLTAVVKLYLQKPESSQGLVQKVLNTATKDCDSPDVRDRAYIYWRLLSTDPGAAKAVVLSVRPPITLPRTTVSAGLLEELLGEIPLLASVYHKPAETFVGQGRIGADSMQARKGSDLADDRLATQKALQTVAAGQQAENLLDFDDDVQNDGQPSGLAATTIFSQTPAAANLLAGTSSNPLDDLVSIFGNASLTATPATPATGLGGFGFGGAPLTPAVPSITPTSLSPRPPQQQPAQSGQDDLLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXY2</accession>
    <name>A0A2G8RXY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXY2"/>
    <dbReference type="OrthoDB" id="2548432at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="357" mass="39530" checksum="80F818C817AEE40B" modified="2018-01-31" version="1">MQAMASCTSPVSPSALIIVPVTLVRTGLTFLVLGTVLSSFLIPIAVVLFFFSTPRLRRQPTFVFNVIVIVLGLMQGVIIFFEATGPMLNKPNISIASSTLLVSLNILVPLCAESVLIFRVVAVYPPHILSRTRRLALYGPIVLLKVTRVINAFYFIHLLLGGPHAQDPYALIQSIWRVPNGKLEWFLQLVDDTYVSGIFLYRLHAGTRNAVGRLPLHSASARSSRYLERLKTLFWISVSNFVFPVLLNVVQLIFILRDPDFTRGLLVFMVNNYVTIIGVLLATIWASGSEVRERASARWMMPPAPGAAARKSFFARPVEKDPSALSRKRRPSSAPPTEKAVVVHVEERGEVSPSSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY78</accession>
    <name>A0A2G8RY78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY78"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="359" mass="39648" checksum="990F413EEA8E7866" modified="2018-01-31" version="1">MSQDPRPPKRQRTSLSGEDSSENSAVGLKRSEEFWIEDGNIVLIASGETAFRVYRGLLALQSTVFADLFASSSPSAEERYDECPVIRLTDSPQDLAHLLRALLPTSRASLYRSRGDPPLSIHQISAIVRLAHKYHVEDLLRQALSALKDTFTSSFKAFDEGFLDLPVNINTMAPLSIAVVNLARLTETLAVLPLALYTCCGHGPTVIDGWERDDGTTEYLSAADLKRCIGARETLAKEAFSLVSAIFNPKPSNDCATPAPCHTALRMTLMKVLETDNVAEPWVLDPWAPFIRDNGQPEHGAGYCYACQRELLERDIKERRRIWDRLPEIFDVEVPNWNEGPEPQGGQGGGENPDANGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ04</accession>
    <name>A0A2G8RZ04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000038">
        <property type="protein sequence ID" value="PIL26751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ04"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027796">
        <property type="entry name" value="OTT_1508_deam-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14441">
        <property type="entry name" value="OTT_1508_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="480" mass="53600" checksum="AEBEAF73A51A092D" modified="2018-01-31" version="1">MSTSTSETTAPTTNNLHTVLLALKRLRRPRPDHILPHLRNPKDPSDFDYLDALATLCAFAGPCDSVSTAVRCSPSLEGNDLYIATSSPPPDPPALQAQLAAWTDLMRTLPVRRRVDSDSDSDVSEDGSESEEPGSPESEEGSGSEEDSESKEGPESEFEDHEYATSTQSFIVEVYRGCHAKLLDIINRDDVGQKVLERVETMPERYIVLYGISRPQLAGYLKCLVALARKKLLTSAEDLLSLYSTAKAVAEFERPLYRLECVSFLRALSDLTLAVDTLVDFATHRKMQDIVQSPWNFIWVHVPGPESARDFVATTNVDELAAIVPSKWRDALTSPTIEWRDFHPTPSGNVQQVEESPGHFTGKGVVHCESALLAYLHANQLYEDKAIQPYIGCSRPVCYACLTLIRAHYWELYTRRIDVGRRSDLEEIDVSWAYPRGMGPAVYKRLVADMVGDFKLLVRNPYKDVFHHIVTDPSGLPEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZE8</accession>
    <name>A0A2G8RZE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000040">
        <property type="protein sequence ID" value="PIL26688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZE8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="185" mass="20578" checksum="1CF423C2418EFB50" modified="2018-01-31" version="1">MEQRTMNDANRDMLSFSRICQHESDVRVLSVSDPFLSLTPRHTKQTRSRENSLRRASSASSEIAGPFIRSPRTAIAFSTFFNAAISLCTTQCTTPVHVLGLSEAPDSHFAQCSGPGQHREGGIAHAFIWRWSSSSSILRRSSASRLGSKDKDRDRDDQPKPDRGASIADPMARDGPVYRDARIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0E4</accession>
    <name>A0A2G8S0E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0E4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="230" mass="25356" checksum="3593E47E794085D7" modified="2018-01-31" version="1">MAFRETRYQGQAPSESSRTEKAKQVASTSRSTAVGHKRSYGDQRDSDSSDSDSDSPPPLPKKKKKKKKSESEGIKKLKRGHRRKPVADEVINLDDVGDNVSGGAEDGVIEVEDEDKEEVEDEAAAGKRGKGKEHAWRAASDDRNGSGAEVMSYLRYTTPNMSVLILNASARGLQGSSSDSEFDLPDETQTKLESTADLLTIFSLQYTKTFRSKKKQTQSTEKGRWCSICK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0W4</accession>
    <name>A0A2G8S0W4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0W4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0W4"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="278" mass="30455" checksum="B357B8981569FFA3" modified="2018-01-31" version="1">MPARALASGKVLVTGDVDAIAHVASPVYLSDGEPSEVIDPAVQGTRTVLASALLHRARIRRVFITSSAAALSSGTEVDLVGRTSNRIDESSWNNYSVQHCEEKGKAAEPVHKLKYRASRACGTLEWDMTVFCPPLVFGPGVHESPSLEAFGGTQAQLYRRVVQGDAGGELGRLTPFGIWIVDVRDLAHAFVLGLQKEEAGGERFVICGFPADWQDLINAARRYSDKIPPGDVSHKPEDVFYPNTYITEKSTRLLGIQYRTADELVRDSVEDFKAWGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S104</accession>
    <name>A0A2G8S104_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_10601</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S104"/>
    <dbReference type="STRING" id="1077348.A0A2G8S104"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013641191" description="Phosphoglycerate mutase-like protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="145"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="374"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="47733" checksum="C3A76894BE6098BE" modified="2018-01-31" version="1">MTSLTALFAFLSLVTLAYSTDFNPLHHSGPASPYFNAPSQFGVPPSTPAQCKVDQAAYIVRHGSEAFDLGMELRKRYRFTKGGDNFTVWSAGQQRVVDTATYFTLGYLSQGNYLSAPGTNRGQVVTTPDSVNFTFADSLTPSTACPLYSQGDTSAKATTFRGTYQGNIANRLNKFLDGLALDATDIGVMQDLCGFQAEVDGDTRFCDIFDESEWLDYEYAHDLNYYYGSGPGNPFSATVGYPWLKAITELFSSDSNRTQGGGNFVPPPLIMSFTHDNNLPPIVSALGVWNSSALPDVYPLSTVRANPDRTFRSSFLVSFRGYIALERMSCDAHEPPTSVTHTSGQVALGPGASASAQKYVRLRINNAVVPLPGCATGPGASCSLAAFENYVRSRAEVAGDFVARCGLQDVKNATNTLDIFTNVPSELAQSTVLVVPLPYAGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1J7</accession>
    <name>A0A2G8S1J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_10576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1J7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1J7"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12215">
        <property type="entry name" value="ChiC_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.10:FF:000005">
        <property type="entry name" value="Endochitinase B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.20">
        <property type="entry name" value="Carbohydrate-binding module superfamily 5/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00495">
        <property type="entry name" value="ChtBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="Carbohydrate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013768939" description="chitinase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="12">
        <location>
            <begin position="53"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="423"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="446"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL27428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="553" mass="59009" checksum="2BC100E906FD1459" modified="2018-01-31" version="1">MALSAVFKRVLFIAAVALAAVSDVEATRVMARPKNYNGTATNHAVTKRASGGKVNAVYFTNWAIYSGFNFQPTDINPAPLTHILYSFADISPDDGTIKLTDSWSDEEKHYPGDSWSEPGNNLYGCLKQMYLLKLAHRNLKVLLSVGGWTYSQSGHFNFITDAGKRATFVSSAVQLVEDYGFDGIDIDFEFPSTDALGSGFASLVAELRSAFDALAQKKGDSVPYQITAATSAGQPNYEHMKFPQMNSALTFWNLMAYDYAGSWLTFADNQANLYGGSRTNVSTDKAIKDYISHGASPSKINLGLPLYGRAFENTDGIGKPYNGIGPGTVAPGVYSYKYLPLAGATVHEDTTDVASYSYDTSKRELVSYDTPDIAKIKAQYVESKGLAGAFFWDVSTDKTGDDSLIGTTSGVFGGLDQTQNHIHYPNSKWDNIKNNMGQGSTGGGSPTTTPTSTSTSKTSTTTSKTTTTSKTTTTSKTTTTSKSTTTSKTSTTTSSGSKPTGGSCSGVSAWGSQTVYVGGQSVSYNGHLWTASWWTMGDVPGGVAGVWVDKGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1V2</accession>
    <name>A0A2G8S1V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_10899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1V2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1V2"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="208"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="393" mass="43603" checksum="E0BD3613BA7B9F47" modified="2018-01-31" version="1">MSDTEGGKKSGYRLEYASSSRSKCSGPKPCKGTPIGKGELRFGSLVDFRGNTSFSWRHWGCVTSKIISNMKDSFNEADELDGFDELKDEDQERIKKAWEDGHVAAEDVPETAKKADGDEEDEEEEKPKKKGGKKKAEEEDDGKGVFKFEYAASGRSKCKACGESIGKDYFRLGNEVDFRGNKSYAWRHWGCAEAKLVEKLKASYGEASEVDGFGDLQEGEKEKVQRAWDEGQIPDDDKGPGEPVETGKKKAAPRKKKAEDGEEKPKRSRAKAKKADDDDEMDSRPKKVAKKKKDEDESGEDFGDELAAVDEEEIDEEDEEPEEPTRKRKRAPASKGASSSKPPSKRVKPASTSKSVKPASSAKPASKAKPTTSRGKKKTEEVIEEEEEEDEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1X6</accession>
    <name>A0A2G8S1X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_10890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1X6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S1X6"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="508"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="567" mass="60604" checksum="0B3AFD05B23C60D9" modified="2018-01-31" version="1">MKFNTPLPQPLPKECQKAAHIFKSFVDSGNNGLDGVIPRSVLENAKGFAIFTVFKAGFLFSARAGSGIVIAKLEDGTWSAPSAIGSAGLGVGGQAGAEMTDFLVVLNSRSAVRSFMAAGSLTLGGNLSLAVGPLGRNGEAIGSLNTSGKVAAMYSYSKTRGLFGGVSIEGSVIVERQDTNAQAYRTDVTAKQLLSGAIPPPEWASSLIKTLESCTGLPGGRQWVQEFQDHHPNDPYMFGGVESPGLGNDPFDSRDFPESPSGGARTPTTGTPPIGNSASGKLSKKKKEKSSSISFPPLQWGRQKSSGSYFGDFHDPSRAPAPADAHAPSPKLSPEDRPSPRLDRVLDPSTGLFETRFQSDYISDDQLRQHPPLNRRTSAGRPSLTLGKGKDGGWDSKKTREDEHEWEPDSPFNDLPSGAFSEARANMSDATSHRRAFSAYAPSTSSAGPTRKSSNPFEAWAAREEETFDDDLLGGGRSAGTRDRDFEAYGKPRIAPKKELTRPLLPHEGVARAIALYDFKAVQAGDLSFSKGQVITVTVKSEDTNTWWTGKVDGREGMFPANFVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S277</accession>
    <name>A0A2G8S277_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000033">
        <property type="protein sequence ID" value="PIL27865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S277"/>
    <dbReference type="STRING" id="1077348.A0A2G8S277"/>
    <dbReference type="OrthoDB" id="2755983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="323" mass="36400" checksum="D0A09D5E7CA0F955" modified="2018-01-31" version="1">MSVSKLTFIPFTPDDTDSTPYAYHSDRDLFRGEIRGGLNTKFALAARIVDMCLPYSKERYARIVVWCLHLLLDGWPAHIPFMNLSDIKGGIEPLRLLRDLLLDGTLRFIPAPPDVRQRALHDPESVLPHVLSAAKLPPLPPLPRTISILRFSESRFSDLIAPRGQVAPLKRRQPVSTTAHVPPAPVPTPAEERVLHPDTLELVLAAPLGPESSRTPRKRSQRCDVNKARHRPVSNPDSKPMRARKVGALTSNFVLDRPTRPSAPQSKPMKPLSELRLPVMVNDRLGGYNTPSRDDGEEDEIESFSDSEDESERRIRAKRRRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2D7</accession>
    <name>A0A2G8S2D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_09957</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2D7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2D7"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="255"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL27922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="443" mass="47380" checksum="38E6B32ED688189C" modified="2018-01-31" version="1">MMVRTESPPAVLGSPEKTRVIEKESFKEPVSTVLVKEALAVSEDCPPDGGLRAWLVVFGVVCGMIATVGLVSSWGAFQEYYQEMVLPDQSTSNISWIGSVQNAMMYAPGLFLGRLFDKGYLRLPVFIASAVFVACLFLTAECTQYWQFVLCQGFGMGLSSAVFFQMGEMVLTHWFKKKLGFALGCVLGGSSIGGCIFPILVKALVQRTSFQWMMRILGFVTLGLLIVTNLTMARRLSGTRHLGPLISVSEFKKPVYSIFVASLVVNTLALFTVYTYLTVSAVSSNLDANLSFDLLAIANAISALGQIGSGLFADRYGPLNVLIPATLLTAVVTYAWPFAANVPAFVVIAVLFGIAYGATVAIYVQPFADMGPVEDVGMRIGMAFTLVTAGVVSGAPISGAILDGTGSFEDVGYYGGSTLLLSAALMAGARHFGVRFKRAYLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2E4</accession>
    <name>A0A2G8S2E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_09971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2E4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2E4"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="333" mass="35233" checksum="0A4C103841119959" modified="2018-01-31" version="1">MAFGTNPRTAVEVTRGGGFGFVGAGYRNPESLNEDFAFIRASFPNLESNKPLPVGYGFIGWLLDKDEEAGKQMIDIVIENGVQAIWLAFGNDLHHWVEHVRSSPANARRCSGHRPLIFVQVTSVEEALVAANEWKVDVVVAQGTEAGGHGGARTPSTFMLVSEVLAALPQDGTAPPVLAAGGMANGTQVAAYLTLGAAGAVLGTRFLLTPESPYTDAQKTALLAARSAGSGATVRTLAFDYARDTAYWPAHINGRGLRNKIVDDVEAGVDHAAVQARWKTATAAGDSSYMVVFAGQGLALMDGIKPIKDVMAELHAELVKQLQKLPRAVAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S355</accession>
    <name>A0A2G8S355_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000027">
        <property type="protein sequence ID" value="PIL28167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S355"/>
    <dbReference type="STRING" id="1077348.A0A2G8S355"/>
    <dbReference type="OrthoDB" id="2985259at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="344"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="629" mass="70019" checksum="BF073E2624C83CB7" modified="2018-01-31" version="1">MSLQDLTNQRREEYAARLPPIEDLDLPPAQRPFSEGKNPSLHLGFQCPWPETTGSAHDSVMEISDRLRRVNREVKAAFGRLDWRLVDVTTVNEYPLSSNIFVVAFYINVHKKLKDDSETKKKLREVLETLRKAFGEGVEGPKWYWDATVHGAESTFPDQAASLSSAYAAEGGASLSSTNPHKTVLLVEAPHEVAPLRRAGRVRLEDQLPHQTYELNLMVDSAGAEPEKSPAEASTVSFEPSQIRKQLPTDLKTWRGPSGKDKMREPMEAIWKVLGPFFAQRGYALWPHQYSFMTAEYGHGVAANGYMYATPFRAYENTRRASTRYQSGGNRGIFPDGPTFLGFPDCACRDTSGSIQSILSYQYRNALTRAARAADGRDVVFRVLSIGEEGREHVDFLKTFARGPHSLISANHTLPLLDLIELEDITFAVFPKVGKSCSEVYGTWAESSVGDILDMIGQCLEALVFLHHYGVAHRDAFKDNFLIQWVSESLRIDYDAPPSRPRVYMNDFELAVSFPVDMPPEEHVCVGPPLGGSLPGHSGRPMPPEVLSGKPYDPFKLDVWQLGTSINDFKSTVAEIDTVLVSMTDSDPTTRPTAYEAMKALLDAICAIPPVSLIIEPELVPRYPIKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3R6</accession>
    <name>A0A2G8S3R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3R6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="150" mass="16597" checksum="F954AC5600252C99" modified="2018-01-31" version="1">MFKLYTSRLATHSSHRVPMTTTHLFVPRKKDASNPPSPHLTNGLLFHAHVLACDVFLELAKNRLREIWDGRLPPPASRSSPSPDLPLPDFMDVIYTIQLARQHSISEVLKHALYEVLSSGEGEFCRALDGAMSGKGSPKVLSALSVARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S442</accession>
    <name>A0A2G8S442_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S442"/>
    <dbReference type="STRING" id="1077348.A0A2G8S442"/>
    <dbReference type="OrthoDB" id="2757832at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="251" mass="27769" checksum="40B00ADD88D69F5D" modified="2018-01-31" version="1">MMILADAVYPTSVTPTLSSSFPHYTPIDPQALPMMRARRRGACVLGTLLVTARAMATTVTVDDGDPGIEYRGAWTHNPWGNQSVNYGSSVTFTNTSGSTATYRFQGTAIAVFGAFEMSGTYNVHSSYSIDDGTATDFIPADTFVVFQYNQKFFQSGTLSNDEHTLVITNLGEEFWLDYLVVTQSPPSTTTTTQSAAPQTPAIGDNTIAFQRFLSDTEHTFLFKRSKRYTHIYGYRENITAPFQQRITIPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S453</accession>
    <name>A0A2G8S453_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S453"/>
    <dbReference type="STRING" id="1077348.A0A2G8S453"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF18">
        <property type="entry name" value="NICOTINIC ACID TRANSPORTER TNA1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL28563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="532" mass="58711" checksum="6D8C8876673C9B03" modified="2018-01-31" version="1">MSKAHQTKGGTLSGKVSGVDVVVKDAGLPSELSQVPSFEEEGSVLPPPPVLTPQEEARLWRKVDRHIMPILTMMYLFSFVDRGNIGNAKLQGLVTQLDLTGSRYNAALSFFFLSYNVGSIPANLVLKKFRPSRVLPTITILWGIVMCLMGLVKNYSQLVAVRVCLGAAETGLASGAFYYLSMWYPRHMIQMRFGIFWSGATLAGAFTGLVAFGISFMSGTAGLLGWSWIFIIEGMATVVVGVVACFVFVDFPDTARFLTPEERAFVVNRMKFDNSTVGEDEHFALRHIWEALLDWQVWALGLLNMAVIMPVDGISYFLPWVFAVLSPRRCADMNGQSSIINGFGFNTTTSQLLTVPPYIVAIVMVMVWSIWSDRIKRRSPFLFSGLLLCLVGFAINITNAPIGVKYFGTYLIVIGGYAAHPAIIAWLTNNLAGHYKRAVGIAFQGIFGNTGGLIASNMFRSQDAPRYITGHGAEMGFVGMGLVLVPIVVFAYTRANMKKEAKMREAEDRGEKYAPEELKRLGDRAPDFRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Q3</accession>
    <name>A0A2G8S4Q3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Q3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4Q3"/>
    <dbReference type="OrthoDB" id="2762307at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="139"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="315"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL28756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="718" mass="80638" checksum="AED3FBC19D182D42" modified="2018-01-31" version="1">MRLLDTETGQFVDKDPEDGKTVYAILSHTWDEDGEQTYEQLKEIQQRYHSGSESQTPQSRPNVVDTDSAASPKLVRALPTALGRLTASEVEALLCLVAETFGLALPAHAPGLSQSDPSMPVPDPRLSQQPPPSQSIWDDPELSPKIREACRIAREDGYDYIWIDSCCIDKSSSSELSEAINSMYKWYGLADVCYAYLSDVPSGEIYQADDSAFRKSRWFGRGWTLQELIAPLWVEFFSKDWIPIGSKHDLVDLVESITKIDEKALLHVEPLDAFSVAQRLSWAAERKTSRVEDRAYSLLGIFNINMPTLYGESDYAFRRLQEHIMERTPDQSLLAWEDVYLASRLRETGEKWEAQPDYDPLDLFATSPDLFRSCRGISTLHHHAITPTSESSHGRAMVEYTSTPYGIRTQFWMLALNKDLLLRAIQHRRPVQLEFPQSPRGSQWYLAILSCEHSEYPEHLLGRVCYIASSKSGIDLIRPGYIKGIELHANGVGNYCTPDLFPLSPDTIEHCRAQIELKTVYIPHPYRAALPQSSSIRRQLYTTMKLVLLRGTHDALRSQGYSANLRDPDPGHPTTHRLVLSNDEHTIAVEFQHTLENDGDDFTIAARVKMSGSHGVQLDSDSAPASHQAGRPTLAWWDATSWETALDHQRVELSAAGPRTLILDLGLNFGGRGYYFLHVEVLSEELPALSAVEPAGNQGGERERNEAEDLSSTRGTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S502</accession>
    <name>A0A2G8S502_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S502"/>
    <dbReference type="OrthoDB" id="2736021at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="14740" checksum="5C8328EDD0FD1234" modified="2018-01-31" version="1">MARGRLRPSDEKPVTSCWLQQRPGPVSDRIWHGILTTIGALVDEYAVGTQVDTSKLLAVGADGKLRLQVIWQGDIGESGQKPSCVLMNPVLGRSPASISEVPFGEPVHTVFSIDFVRDLRAGTRTIVASLFALMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5Y7</accession>
    <name>A0A2G8S5Y7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription termination and cleavage factor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09239</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5Y7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5Y7"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.70:FF:000001">
        <property type="entry name" value="Cleavage stimulation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 2 hinge" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription termination and cleavage factor C-terminal" evidence="5">
        <location>
            <begin position="159"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21492" checksum="C7C90111AB0FF316" modified="2018-01-31" version="1">MKAFIITHPEQARALLVAHPQLRYALFQALLLHKIVHPDILNQMLAATGTAVPPPAPVPAPAPVQPAHPAPPPYMTSAPPPVPMYAPPIPPSHTPIQHQTPPVPPPNMYAQPPPQMPPPYYRAPPPPGPPAPPAHMPTPTMHAPPPAPPAQLGGIPEFDQAQRDMLMQVLNLTPEQLNTLPPKERDQILQLRRQFGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6R7</accession>
    <name>A0A2G8S6R7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8S6R7"/>
    <dbReference type="OrthoDB" id="3247418at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1693" mass="189804" checksum="913F92ABD6B0C414" modified="2018-01-31" version="1">MSRNVDVSIVARRPSVGQVLATPRDCGVRTISTIENVELFVHEMSVTVRSGTGIQNLTIRLTGLPIFQETLVAPIRTSLQLVPELTDLTLLLPLAPPPDLLLNLKFKALQFFKSNLPHTALTTFLARHHSVSDLVLGPCGPAKPCPLYDVDLSHVTNLECEATCVRSLAHSDLFRLTIGKSTEGPRVGVVFRTSPVCVSGLYSLTIDFFPDDIDVLDNLSLFAPFLRKLRLLEQRGAFRHNRSGRRPFNDALVWARALRKLRFLEELSLQTSAGLILRPGDYHLERSLVLSWVYGVRTWALRRPPPSAKAHPTLYHVRLWYGARGNDPALSKWFKDGEEWRRLGRPILWALRTNPATHLPTESQPHRDFTPLDADSDMASTLVLPPDGEKSPTTGASSLAGPHSATDSSSETSSPRSSPPSSVNGDDSTVELAVKALMSSAEVTHTLSSLLMRSHELVSRVSENRTTAEEDSTAGLDDATQESEDMLAFATLITRTLEAVKQLAQLQEESSERLFNLESTVVSVWGDMERVQSRANRLLYRTREHVRKERETMRGEERLAIAAQGSLIQDVYRLNLDLISMNERNTMILGGLRGLEAALEELKANDARASAGPPALRMLWDVLQDFGWGVLEFLGSGACCAFGWMLYSFKTVISAYVLTDRMNPQDVALDSHVELHGEESRRTVQESAGASNPDTIQATVDPLSHLREASMPPAVQDAPGLCVDIEDPFALEFEVVVDDSVSPQDRLREVGDIQSILHRAEACFRRPILKFTNIPQTLNDPPSDLDASDPFTAEFVEYRTVTLPNLHTRASQLLPVGDRNVDQLHARLVEDIKTYTERAIRSQLDAWRDEVVKLPHANLDALEDGPPIVTTDDVFVARNVMQPFVTVALIIAVVLHSMAAVARPEVAFVLSGLRAMLFGAFVWCNAPSRTMNAAQRLLLKCIPRDVRTVLRTLHLEPDIVRLFVDWFNPYGNKKAGKSHSIGAIYLACLNLPIDMRYAPEYIYLAGIIPGPREPVLDELNHFIRPLIDEFLVLWTRGLYFGRTALRWTGRFVRAALIPLVCDLPALRKTAGFAGHSSKHLCSFCPLPKDDIGNLNRSTWPARRTRAEHLRIATEWRDATKARRDEIFEEHGLRWSELLCLPYWDPTRFAVLDSMHNLFLGELRHHCMNVWGIDIRDKSPGSKKLLPHTPEEQTKFLQNAVDALKKRSATALGKLRKGYIVSIAKLNGVTPTGAALTKSAYINALLNWVQTVDADAIRIPPILDHDATDFHLSDEMGADISKYRVLSYDVLQSIRADLRSTYLPSWLERPPSNFGSPSHGKLKADQWRTICTVNMVVTLVRLWNSPEASPHDKLLLENFLHLVAAVDMASRRSMSRDRALAYDKHMFSYLCGLQHIFGHDFVPNHHLSLHLYECLVLFGPVHGWWAFPFERYNGLMHRININHKPAEMPLTFMRYFYIGANLCQLMASLDLPNDPEYADMMSSFSCAFSVAARGTDRFNPLSSLSGPHRDNGQATSKVREMELPKNIYDAILHLVNQSGEEAFASDYTTSFGHTDHLVLSPTARELNRIEHGKVLFSTRSKGVRDSFVIFKGPDGDSHAGQIARIFLHTRTRLGELVVEPFILVDVYEPLSGDDEGHDPYRKWPDIHTCLYYNAFQGDSQVIRLQDIVSHFAAFTYTPDALGRECVVVRDLDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S935</accession>
    <name>A0A2G8S935_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S935"/>
    <dbReference type="STRING" id="1077348.A0A2G8S935"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="713"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="501"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="575"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="587"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="804" mass="87881" checksum="F0B46BC411952E5B" modified="2018-01-31" version="1">MDADLIKLVNKLQDTFANLGGELDMPQLAVVGSQSAGKSSVLETIVGRDFLPRGQGIVTRRPLVLQLIHTPVPDTPADYTEWGQFLHIDKRYIDFNEIRREIEQETFRVAGQNKGISKLPIHLRIYSPNVLDLTLVDLPGLTKIPVGDQPGDIERQIRSLVLDYISKPNCVILAVSAANVDLANSEALKLARSVDPQGRRTIGVLTKLDLMDAGTNALDILTGRVYPLKLGFIGVVNRSQADINAEKPLGDAMESEGEFFRNHAAYRNIAHKNGTRYLAKTLNQVLMGHIRDKLPDMKARLNTLMGQAQQELNSFGDAAIYGDKNQQGALILRLMTQFARDFVASIDGTSMDISTKELSGGARIYYIFNDVFGAALTSIDATHNLDNQDIRTAIRNSTGPRPSLFVPEIAFDLLVKPQIKLLEAPSLRCVELVYEELVKICHNCTSAELQRFPRLHAQLVEVVSELLRERLGPTTDYTQSLIDIQTAYINTNHPAFIQGSAAAAHSMTAPQPKQILPRRKSVGRHARTQPSSAESINGIIGNVTDDDESQDETAAPNGNTNGLSAALNERSSRSPAPPITVPPRNAPGKHHQHQHQHHHRDATSTSRNVSGASSGPGSSPHTGTAKETFLNYFFGQNGPGPLSGPNAERAGVSAPTGRDVSGADPALEAGLMAGKRGTMDRSNAAYDMKSLGRHIEAASDGSAQLTMREEMETNLIRSLIQSYFAIVRQTIQDLVPKAIMHLLVNNTSQQVQNRLVAALYKPDLFGELLNEDEALVAERTRVKALLDAYRDAFKTLSEVTLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9A8</accession>
    <name>A0A2G8S9A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9A8"/>
    <dbReference type="OrthoDB" id="2658589at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="838" mass="95382" checksum="F7385500E716A548" modified="2018-01-31" version="1">MIPMQVREQQLGPPVYRTPFADEWTKLEAMLIQVRNLLQKHRLDPVLVTLDKEHIRGPSSEGYEAWLTDRAAAQRRAFFARRKFLYHIAIISFHIAALWKRTNDPRHWYDYLLENGVQGHVLDSLSASVVADFTPNNPRAGLFIKPDAFSWSTYLPVLILANVPIFVYWGPVRSRIAAPAQLNSLKPSKEAVSAAQQLLTDVFDTEGRQPSFETTGRAPEFLSTDTPGTFFAERAAYRAARIRIETEEQRQRRLSREKRATSYLITSNGEDTVFEWDFDWERMRWKREIVLRHDRLSAWSGYDKKDKRYDSVVKEWDLAYFFESSVREARDGEELDEQEVNDHSSNPLFRDGDCKLDPPPPPNPPPPLNRDDVPVEEVPDIGGTPASAIQTPRPPTTTLVTPRVPTATLATPHVPTATPRVPIATTSWLPTAPTGWTSRAATTISGPPEDGEIGIDGEWRPNFPTLMAVLISRHLFRWGISLDDLPLPDGKLLSWSQACKAVGFCPTPEIKCTLDAGKSEGANAFATWVSCMVQNTHPPADWWLLASPSRLRELLRTNDLRIFHLEDPHEDRNLRMWCLDDRGHARYKRTWFAAVENPSTALATAMSHRSIDEAVRWMITTLIYSPRASYEVKQGLKMMDPHLGHRPLRRPTNYVFNVADFCAYEEFRDHFLQANPRIGRAALLAGGILWRLAIESVERDLVLDGPNTIKTALGITFALRDHADDVFIDDSLTADEIHIIIGTYTRDPIFWRNVSGSGFPSWWPDSGHFEASSLDFGWWSPVAEAWYCELRAKYRKGNAQPKTGPEWRNVLRNRDKRARMFTEHSKTAAAAFLRGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9C4</accession>
    <name>A0A2G8S9C4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9C4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9C4"/>
    <dbReference type="OrthoDB" id="2724111at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38839" checksum="8B6567EAC60BA5FB" modified="2018-01-31" version="1">MDKCPNEILTLIFVEACTDDGLAGRSLSLVSRCIHDTSRRYALQSVALYGFYQLSAFASLLDKSDPEDRYVRHLYVSDRPRGWIEYLPGQGREDWLAGRVDEHFHFDDPSPNHSTSSLLHILKTVSPTLETLALLLFDRYDKQPLSDALCLPKLRELTLHGSNLTRPDHSELAQCLALRRLHVVQNVSIRGSMTKAVSHLAPLLTHLRISRIVANRFASGDVVLGLESMLQQDDLASTGFPPTLKCVLVQMLQVGTQDRNGHAAVSPSLMAQQLKDVAMRDVQRRIVLLKPTIVLWGAVGTLIGEISDVEFYAALKLAWQERVSGAESAVWEVESSSILASYGYYAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9I2</accession>
    <name>A0A2G8S9I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9I2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9I2"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1020" mass="109472" checksum="C68B49FD971B49BD" modified="2018-01-31" version="1">MAQPLFDQHPLEQYFRNTGETSEPMPGGSPDFAPIGEDDSEDDLHSSPPVDIQFPEFVVWAAQIAHDLLQSSSCSSRDNGFEERFKYDIISSSLLSSSLAAPTVTSRPSLTPEIPGKLDGGGGSVGDEHSPSGSNPDFPSPDSSAPLDSNFSGPESPIALLSIAVAFLSTGFHLLAIVFFAAAIYVRYVVQASHSTSDSLSQTLHALNELISAGNVWDSAVNEAIVLIENEERSIFYGPTSPQAPSSAVRIALQSSLFTTQTQCDNVRQLLSALTCPSSLSQLTEMYAPTSPIRPPISLAEPGSSPSSSTMRPFSHPSARRTSPTSGEINKRATWNGSYAALAGAGSPTAHLLSNRKKQNRRSNVISMFPPVSPRAGAFSSFSAPVTPEPISPEEGGTHLAGVLEEEDDTVEELGDKNYFGAAALDLQRKRRSVALEALGLPPPSYTPPKSPTRVGGRPLSLLSPAIPSASRLTSVHTTRHPLSLSGLHLALQGALAAKRYACSHLLALRFTEDEDDSYWENVRSVVALLSTTFSDASARLVEALGDAEKRRKKDEHPTPPRGNTPTPGGNGKEYVRGHERKNSPLRNDYTPRSLMELVSFAPMPSSMARLASHVETISAALHDAREHIDECVGALRDPPSRRASLDASNVQTHPAFQAYDRLRKELGFALRECERGRERLLDVLAPRPLAGALAEADDEDAAPHTPGLRHDSDSETSEKGPASPRVPNVNAGLGLTLSYGREDHEHDHDLDDATAHLLLTASSQHLPPPGVDQVFEADSGSGAAFARPRSKLTREERIRLAKARRASGRLLSASSVGAGSADFEAMPMPAPARERWGPGGEVVQELKDVIWKVGEKKRKMSQQVQMQGPRALDLEPAPTTPVLDLPVERAEGEEGEETEKDKDEAALRALPVPVPQRETSISIDVVEGSPVAEVGERAYSPPEATEFETEVEVESELAYLDSPPPSLSLSLRDPHADSCLMLESSSDADDTLWTAPHPTPTPAPSSGLVLEGESRLDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9L3</accession>
    <name>A0A2G8S9L3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9L3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="164" mass="18522" checksum="98C26945E72F8AEC" modified="2018-01-31" version="1">MALQGFQLVGEVWMKNQDESMGGVPTYTIACATSKHSEDTNHLGFVQRRFQMPSQRAIQSRGRLQRAGINDLLDRARRISLDTLDLRIRLRHTNDRVCNLNLTIMENTAKVEALAERLVGLRAQVDQREHDAAAFRGHVNKRIDMIELGLKAIMDHLGIPAPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9M5</accession>
    <name>A0A2G8S9M5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="9" type="ORF">GSI_07159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9M5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9M5"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL30460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="227" mass="25185" checksum="EDAB36E66D5EEF4B" modified="2018-01-31" version="1">MLCTPRTPAIRPLLRCLSTHPPPPLPSTAYTDRTRPNDAAITATPDHIPPIVQHQLQSALRVDQAGELAANYIYMGQHHVLGRDPLTGPLIQEMWDQEKKHLAVMNKLQIQHHVRPTLLWNLARIGGYTLGALTALMGKEAAMACTEAVETVIGEHYDDQLKAFQDLPPDHPSVPLLKDVIREFRDDELEHLDIAVQNDSQKAPAHALLSTVVGSGCKMAIELCKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA55</accession>
    <name>A0A2G8SA55_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA55"/>
    <dbReference type="OrthoDB" id="2734765at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="284" mass="32308" checksum="75D3A747CC0D99D8" modified="2018-01-31" version="1">MLYCTKQCQKRAWEFHKDLCGPKTEEEAAKLGYSSMASVVIALKRWASAHTWALQAMVEAIAHKTGGGIDDHLENQRAIVFVVSQGKQDRKGPRNPAKAFHLDNGGLVHKAEQYFLDENWHILESRCNNLTAAMRASLPETERRAFAGFINVAFHFLPTGMTSFHHYPVYRLRTHGGRPSYDISTTEEERALYSDVVQICSSYLTQGLALRAPGGDYNRPSLPEVGSYERVKKKWTWVRFPNYGWSTYKAKDSPPKLTAETLMRYHGLLAQRNFDENLFDASQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAG1</accession>
    <name>A0A2G8SAG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAG1"/>
    <dbReference type="OrthoDB" id="2734101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013876659" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="15164" checksum="0DD9989BC6E9CE82" modified="2018-01-31" version="1">MKFALSLVAFAASALAQHIEIGAPNNFAEVKAGSKITVGVNRPNSLTGSTEVGIAIGLWPCGGPKGTSKCASTDVSQVLGNVVYTGSYKAEYDSTQPSKPPHQNFEITVPSSFSKGEVSLGIAHLFLMGAGSEPVYEFVNTTLVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB69</accession>
    <name>A0A2G8SB69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL30983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB69"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB69"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="153" mass="17296" checksum="6B1D4CAD603107D6" modified="2018-01-31" version="1">MESSIPFVGHEFRLENPQIPPQSVFHRSVMYSPQKLQSPKYMITMKIITDSFGPGFAPQYPSLNEFEQYCKDHRETGISPVNGFIPTSTVARRTEIHSMLLVRHITSILQFFQAFGDAKAIKLEVAKVPPQIWGAVIECVELPSYLRLVSVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBN9</accession>
    <name>A0A2G8SBN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBN9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBN9"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14504">
        <property type="entry name" value="DUSP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000157">
        <property type="entry name" value="Protein-tyrosine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054498">
        <property type="entry name" value="2H-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052732">
        <property type="entry name" value="Cell-binding_unc_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021122">
        <property type="entry name" value="RNA_ligase_dom_REL/Rnl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883:SF1">
        <property type="entry name" value="GLUCONOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43883">
        <property type="entry name" value="SLR0207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22547">
        <property type="entry name" value="2H-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09414">
        <property type="entry name" value="RNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="334"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="375"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="879" mass="98109" checksum="949845F964DFC70F" modified="2018-01-31" version="1">MALQWYRGCLALVGPQVDEIARNQISHMKNSVQAQHMPHILDPSSSFHITLCTKEESRDNAVKGSLPPLNSVDTRHLHVLGVGGNPKLGVFFVVMIWAAGQTLRKRVGLKPKQFHITLSQHDDYSIDKGPDSLLNQGSSTNLPVHRNNPDLLDHLAFTFHLEGRYDRARATATDLCKIAPTLERGFLRLGDAGLKEGQYKLAMLAFACAFERCSDAKVSEYCLKKMEECSLYTEWGCAFTDPERGQLHEAPRELLEPWSATFREELSAREPQAPPSLCRLAREPVYVPYPTSTSAPPYRLPRWFRWLIPFRIALMSTPRDAADIDALASPHLGIRHVLTLTEETPLNRAWFGSKNIRNTFLPVPNYHPPTIEQMDLVLRLLEDERNAPMLIHCGGGKGRAGTVAACYLVAYGFSKPDSSRTEPAMSASQAIAALRAIRPGSIETEPQEEFVAKYCSAIWKRHAVLPDLVPEPAPCPLECEGALPVDADLFMLVGLPGSGKSTFSRMLMARDPRGWTYISQDDTGSRSACETAIGNVRGGRVLLDLCNVSHAGRKEWLALAGHWAMAPVCVWFDYDRALCTSRAQNRVGHPTLPPGNRVRHAMEQMHGAFVRPTLAEGFKAVFAVRSFAAAEELVARLSPPVGLFKFPRTAHILDLGSATSDDIVASVPAMASGADPRAHAHVVVTEKVDGANMGFSLAADRTQVLVQNRSHYVNPVSHEQFRKLGLWVDRHREGLIRVLDRDPLFAQRYVLFGEWLVATHSIPYTRLPDWFLAFDLYDRSTDSWADRQTLEGLLRDTEIRIVPVVHEGKMPKEEELREMVQRPSMFYEGRVEGVYVKVERDGRVVSRGKVVRADFIAGNEHWSKGPLQLNALELSTEPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBV6</accession>
    <name>A0A2G8SBV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBV6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBV6"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="165"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="39017" checksum="66057FD330D876B9" modified="2018-01-31" version="1">MPDHNGPRNFEFEREQPWGGGAIMNDADTPVSFLFRGPVLRRPPTADGEPATDPVGDEVAVEPPRGLPPPCLKAPPPRQYRVKPTTRSDPPFTYDPADIVVMNGQRWVTTDEGEIRILDVEELPVPSTRMPMPKRALAEPIPGVSKPSRGRHVPTKETAGPDRKHPCTVEGCGKIFTKRAHLNRHIASLHRHERTWSCFAPYCDKSFTRFDNYLRHQSLHSHYQEILQCAPADEYKGVHLQNPNVTDPKSFNIKPFAAIAIHPTALNLWRFQETQRMNGVDLPRVSDCDKYFAAHPEQREAALRGDPEWEWRLPQPGKEFRPIDGRCLEGTFRVNVKSQDAPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD03</accession>
    <name>A0A2G8SD03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl transferase 64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD03"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD03"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57255" checksum="14DC00B7B65AB79C" modified="2018-01-31" version="1">MATREQIWRAFQAVAVPVLLGLISRQIWPSRPEQTPTSLYLPLLADIDFVPRTLPATYRKHDSHFEAYDHVSLLPEVAPAATPDVTAVILNWSRFPNVILIASLLCGPWLEGTISEVFIWNNSPRHITYEEMKNTGCSKSKLRIYNAPSNLLFQARFVACAQASTPYCFVQDDDYLVRPEIIQSLRVHMAAPDASRVIHLLPPHEHLSTTLRETDVQSSHDRQLSSIQTSFAWLGHGTMLHRSEAQSFLRLMRYLDAPPDDMKMADNFFTILSNRVPEVWHDQGFELGGGQPFTVGSEGDDRNKKYILRATRYLESLAHCGRVSCDGFDRNGSGDQQARPQLPYITLDRLHPQKPWIRAACRVAACVLETNIRTLPDDVSHTATNISDMLSLEIENARTLGDAGKQNYLDHAPSNAVDGKAYTVFRSLYGGKKGDKITLDVLTDISEARRWTAVELVLLVDSATEVILNSSLFGWSSDDVTWRSRMSFHVIPFATILRKKPLLTACNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDG9</accession>
    <name>A0A2G8SDG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDG9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="275" mass="30478" checksum="23DC8F2B0B92C647" modified="2018-01-31" version="1">MADFSTMQEVLRMRQSVQEDLRPYALRAVTADWEALEAECADETKPIRRQVAYEFFASLEHLHALDFHDPTIGVYVARASLLLRTRGEHSMADRLASHYNRWASEQRWSETAANYVLSLTEREHAFHARVLVDRFQNEMSREVLAAAEEMAFRVRSVYNDFRLDFRALEAAEDPPRMHATLRRDWHLVVCERPSVVDGEPEVIPSATGAPMSGQPSAAGEVSGRGGERDVSEAAESEGSGRRSSESIEEGAPAVLRVGEEPSAAPAVSVGAPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE56</accession>
    <name>A0A2G8SE56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE56"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE56"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="259"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1052" mass="119219" checksum="FC1900022AC5FEB1" modified="2018-01-31" version="1">MVQGGLFTDTRIIAIRVNAVYYVSASFDDTSQKPVIFFSLTHPPAFESESTLSALTSILSPTYKPIRHRWSSFVDNDDEHVLIVPYTCLAIRLECESIEDLHVFREFVDAAHLRVEDDAYPIVRRDLFSSATRAEYHLWIMTLPWTMAFQIEALLRSWLLNMVEAVSLRGMVDRLVKTQGAAYTVALLRDFASHAKTLYWYGGTQPGAESNIQIQPEVAWSDPVTHLFSQVEEAFVFKPVEPSASMDPSAPFQCLHVTITPTTMILEGPFPERSNRVMRTYYRNQDCFIRVSFQDENRLQFRFDRDVDGRSFINRRVRGVLRDGILIAGSHFRFLAYSQSALKEHAVWFVKPFRHHWQDEQGHEHFADVDATTIIQSLGNFHVSFDPELIRCPARYAARISQAFTATDASISVSVEQLKRKADIKDSTGTYCFTDGVGTISPELAKDIWRALRERGRRGRRDGTYPRAYQVRFQGSKGMLSVDYTLLGRSIAIRPSMIKFEAPQSLEIEVARAFDKPGPYFLNRPLIMLLEGLGVSYETFKHLQDDAVHNAQDSVTSLERSARLLEAHGLGMAFRLTPTMFGLHKLGLGPLDEDMFWRRMMDFAINHVLRELKHHARIPVPGRESWTLVGVADVHQQLREGEVFACVDSPNESRPIYLEGPILVSRSPTIHPGDVQVVHAIGRPAAGTPLAKETLRNTVVFSTKGERPLPSCLGGGDLDGDLYNVTTRRDLLPPRTYKPASYDPARKKLVDHECTMNDVADFVAEFISSDTLGMIATTWLIIADQSPDGIFDADCTKLAALHSDAVDYPKSGQPVPVNEIPRLKFDMKPDWNAPETVNANNGNYYKSQKAIGKLSRLIELPAVQIVQRAGKSHRRCMQKENQREQCKDLLGQFYDEPPALDEVGVAIQQRIAEFIDPDEYNDDFICHIWDLYNSYTSQLRAICADHTLEHKRTAMLTEEEVVIGTIVAKCSQPRKRKDLMSHMREQTTTLVSSVKDEMAGGDTFPFEWSLQRAWIAYRLAIMEDDAFGARSFAWIALGSIFDAIKDIEDEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE78</accession>
    <name>A0A2G8SE78_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWI/SNF-like complex subunit BAF250 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE78"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE78"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="68925" checksum="392D2D86CBB5F093" modified="2018-01-31" version="1">MDGPLHGQLHVPQMPFQPPNMMGVGGGMTTNGANHPPMNGVPMTKLASGGYPAMPGGGPNGTADIEHDMENRKRKMQEAVESDAKRVRQKTGGSDVSDTRGSVAPSQPAENVVTRTILQPSRRKIAYVPLAPELETTGGRNLDFIQNEWHRLASRPLRHSDEWGHVDIDALTLSLRSRISTELSYSLTTFALLTLARNQHSQQHGPREREGGFPIMQAPDLLDEAVDLIEDLGFSGVEDDEDIEDDGPLVTHKELVNTLMEDGSKPFAALQPGPGVKDPSHGPRQRQADIILTAVSIIRNISQGDEHSAQYLAKHEKLLHALVRLCSLAPRSKSSGPVPLSPVLSLSDLIALRKDLVHMVVNFGVFIGLLPTPVPSKQMQRTIRRAYEIMASFFVDASETVSPFQYILQTGIQLSQPQPKPPAPPSLANQALEAFARFTLSDDSRRAVAMSVPTTWLWTTFEALVHRLPVTDHDFHAIMREPWIGYVERLVLCLYAIAFLAPPELKERAKRNSTLGFSKIVLRLLKKFVLQTPPESRNTFTFLVGRAIELLKLVDDAGDSFDPGNAAMPPLSFGMGYGEHGDNRIERGLGMLCAYQEDVTLGLMMHSEFLDPALFSELESLVRVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEW5</accession>
    <name>A0A2G8SEW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEW5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="182" mass="20406" checksum="FD7B9DD90E77701D" modified="2018-01-31" version="1">MASTQRTCPLKCDNDRPTYHAVHMQFEESEEEPDAAGTLDRRLVALGHSAEKHDAAQIKLAREAQVVAAKVKVQTRRLVAHHDKIARLYAETTMLQEEAQEVTNACQEQAHAIQELRRQVYEAECNVFHRNLTCTHTVGGKVTSLEDSSTTNVVVPARRSRSAERGLDPSVPQTRQNDHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGD1</accession>
    <name>A0A2G8SGD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGD1"/>
    <dbReference type="OrthoDB" id="2772415at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="128" mass="14179" checksum="F0CFB34E79EA600D" modified="2018-01-31" version="1">MAATVFRLVTVNTAPERAKRLIGRVVEDVKDKYTIVHAANVERIQDVKATVEREQPNLLFTASMWTPEQAKEIVGIAKATIPGIKTFSLPQGLQVQKGPDAVVEYIKENLPGLLDSYQPSSRTFSTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGQ9</accession>
    <name>A0A2G8SGQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="7">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05005</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGQ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGQ9"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="736" mass="78313" checksum="2C5902BB4491AAA2" modified="2018-01-31" version="1">MASSSNPFEGPRDSLVDSALDTPRGSAYLGPPGALRDSSALRDSAISTPAESSPFLPQTNKEAAFGNSQDVLSAPRRRPLYRRPWFWVAAIVAIVVVALAVVLPIVFVVVKPGQHHTTSSGSSSGSSGSNDSGSNGHSGSNGSGSTPQGAIKTGGDGSTVTKDDGSTFVYHNPFGGYWVSDPANPFDNSARPNSWTPPLNETWQWGVDRIYGVNIGGLFVIEPFIVPSLFEQNAGTVDEWTLSQALAAKGSDTLQQTIEDHYNTFITEEDIAQIAGAGLNWIRVPIPFWAIEKWDNVGVDPSTGATVAEPFLARTCWKYILRLLGWARKYGIRVNLDLHTIPGSQNGYNHSGKLGTINWLSGIMGLANAERSLDYIRIIAEFISQPEWRAVVPMFSMLNEPFLHDIGQTPVQSFYLKAYQMVRDITGTGEGNGPMITIHDGFTGTANWAGFLSGADRLALDTHPYFAFDGNANREPLNITADGDATQLGGQWPLQACNSWGAGMNTSRTAFGVTMAGEFSNAINDCGLFVNGIDGGARYGPDCGYWEDASGWSDATKEGMLNFALASMDALGDWFFWTWKIGNSTTTNTVLAPLWSYQLGLQNGWMPTDPRQAIGKCASLGGNAQAFDGTFQPWMTGGAGAGTITAATATLVWPPTSLTSVPAGSVTALPQYTSTGTASTLPPPTFTATVTASVGNGWFDSKDTAPAVTAISGCTYPDAWNADDAQIPVSGCLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHP8</accession>
    <name>A0A2G8SHP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHP8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHP8"/>
    <dbReference type="OrthoDB" id="2800059at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="36"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="354" mass="38632" checksum="BBD8004DE619EA55" modified="2018-01-31" version="1">MSSGSDGPRSSKRTRVDEEDGPPVLQRDEDVWLSDGNIVVIASDTVAFRVHKSILSLRSEVFSDLFSLPDANMAETMDGLPVVHVSDSPDDIRRLLLVLCCGKNYYYNRDVLVPVPFAVLASLIRMAHKYAIQDVLDDALSRLKRYYTNDLSLWRDPDARARYVTATAHDAPAAVELARLTNTPLLLPTALLVCVGLAETYSVADDGSGGAAESHVATLSVPERARLVHVKGYLTQACATRALYLVAAVPSAGCASRRACTASKEALLEEFREPGNVYSLRVRHISDGNALTPIAEKLWQDDDWERFCGVCREALAKMDAKGVKALWSTLPALFEVDIDKDVWRNGEAPAGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHX9</accession>
    <name>A0A2G8SHX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_03996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHX9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHX9"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="66"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="121"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL33376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="333" mass="36321" checksum="1832C6EF695A8D66" modified="2018-01-31" version="1">MVRVLICGDLVWAHKECEDLFRGLADVVTMDSPNRADFFAGLQPGGKYDGIVGIYRHNVSTDFIGIFDGELVAKLPATVKWIAHNGAGYDQIDVHACKERGIVVSNTPGAVDDATATTALYLIISALRLFAHAEQDLRVNKWKASHRPGAAHDLTGRTLAILGLGGIGLRLAELAHAFPMRVIYHSRHKVAHAPAWCEYYGADRLDALLAEADVLSVHVPLRAETEGFVGEEMIRKLTKGAVIVNTARGKVIDEAALIRALEDGHLGAVGLDVYPNEPEVNPRLLEFPNATLLPHMGTETCDSQKKMEVRALTNLRDYLTTGKGSDIIPEHQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIB0</accession>
    <name>A0A2G8SIB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIB0"/>
    <dbReference type="OrthoDB" id="3358294at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="211" mass="23159" checksum="6EDD3D8AC7F57A65" modified="2018-01-31" version="1">MSSPIASSSTSRPLSFGLFDRPTTPAHDVDLEAQLAQPTLALTHIPHTTRASVDETTDAIDDFFGASRPSSPHRARNTSLSGTRDSRHDEVRLTSPVDDPSMSDALPPPYEHSISPPAYSQVSDQPTLAMYLFKFGFLFPLFWVAGALILLSPLSAPADWETSKPELEREELIASMRRTEVKWARRCLLALSVFALIVISLVLGVLFALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIR9</accession>
    <name>A0A2G8SIR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_04287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIR9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIR9"/>
    <dbReference type="OrthoDB" id="2756257at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013802480" description="SH3 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="608"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="673" mass="75573" checksum="75EAA2AE3A07E1EB" modified="2018-01-31" version="1">MFTFRCLTWGFFLAYLSIGEFAFGKPARRSQTAFNVPKHKAQPVSCLQPLEFNDRYQCGLFEVPLDYHNVSAGTGQIYYARLPADEGVRKGTIFVDPGFQFATGVWRGSSPRTWLFERGEVLHDSTGGEYDIVVWDARGKGTPLDTLTVPGPVTCFTNTTERNEFYDRAAAELGFAAEWDYNLEYRHMQGDKDIEQWYAVQKKVVEHCLGRTDTSMLPYMGTAASARDLAAMADAFDGPGSLINFWGIGHGSLIGSYLLQIFPERAGRVLLDNPVDPETYSEEDPYLTWRRDVQWANKTFARFAQGCTEDHDTGCRMAHNRDPEDVLDWTAWAIDAAVAESRAAFGGWRQQQIVDVGNHHYRSLLEAVYGHDGLDGGPFTERHLKFQSRLAGELDYLDLGPMPIFCGDLNLMPNSETMLARGRKMPGDLITSKADAPILLQTAFPSLQYMCHLWPVRAVERWSGLVAAEHKRPVNPVLVLGNDLNPLSHPQYSESVLRGLRGLNEEYREDAAIVFQTQFGIPTFGHGRCVSDVISAYLRNGTMPARNRCYGNGISDDGSVLAHKNQTEHSPAAVRQRLQTQPYSSISLCSWRAVEPLPSGQKTNHGRPVLFYAKAIFPFHPSEPQDLELLEGDIVGVARIRKDGWAIGEPIDEARRQPRKYLFPSNFVCVLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIX1</accession>
    <name>A0A2G8SIX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIX1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIX1"/>
    <dbReference type="OrthoDB" id="2930792at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="360" mass="41209" checksum="7ABDACAFF701132C" modified="2018-01-31" version="1">MSGFSYPDILEAAKEMTPKKYLVYIITNIGFAWPNEPWFMFDVIPIAPCLPPNDGVSTPEMCVPVFPNTRHPSGRMHIHTNPQFPYDNCYHWSHARQLTVRIRAKPEQFDDDRATKLEPRELLTFWELSGPDRTCEELPEEDQSAHDSESCRSSTAAARNAPSVHSQEQQLEGEPASEDRNKDSRHPTSGSPKWNTGTAVESPSMRSFESASERSARAECRSIVRTGIFGDPHEDKEVYPLVDLWVELADTLKQNDIPRPEDFYKEYDMVENLVVEAKMRRKEEERLETSQQPIDELEMVDTFDGAQGEPTDLGKGESTMQKTRKSCRPKIVIRDLHAQAVRVLVRIKHALRLPYVSIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIY2</accession>
    <name>A0A2G8SIY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIY2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIY2"/>
    <dbReference type="OrthoDB" id="3067625at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47823">
        <property type="entry name" value="lambda integrase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="183" mass="20225" checksum="C1CB18D9688BDBF3" modified="2018-01-31" version="1">MPGSNQKRTDGAGITPSTSSAETVAVPEDHALAIMGLACNMPLSKPTALPNVEPSVPHDHSESTFSPPPPRLWFEAHSQFSRQVASYLWYGPAPDWWSINRVGQKSFIDFVRRDPAYLNEDNSVFPATKRAVIEWIAHLGALNVRSETLKSYLIDVRALHIDAGYPTTVFESPVVQCLIRGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJ01</accession>
    <name>A0A2G8SJ01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJ01"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="111" mass="12127" checksum="FB0FE1520D65B3D2" modified="2018-01-31" version="1">MLRAAIAAPAVAATLRPAARRPPRARPGSRVCPCAHLRPWWDRRSPRASRRNAVSTTRAGPWRLRLRRRTLASRRSHSRSCGTPHGCGCVGGARICFATQQGGQRAGPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJJ3</accession>
    <name>A0A2G8SJJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_03593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJJ3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJJ3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="38"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="289" mass="32233" checksum="7E7FBBFE1D8CD26B" modified="2018-01-31" version="1">MISPQGLSIASTLRLSSGYDMPVLGLGVFQNYDCVPACLAALKHGYRHIDTARYYQNEDQVGRAVRQSGIPREEIFVTTKVYDQDQGYESTTRAVDDSLQKFGYGKQPSLGAYADYFDLYLIHSPLPGKEKRLQTWRALIDAKKAGKIKTIGVSNYGAKHIEEIRAAGLELPAVNQVEIHPFCQQRPIAKYCKEQGIVVQAYSPLVQGRLDEPVLVRLAKQYNKDAAQIAIRWSLQHGFVPLPKSSQPERVLTNSQVYDFELSEEDMAALDALDKGKAGAITWNPVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJL0</accession>
    <name>A0A2G8SJL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJL0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJL0"/>
    <dbReference type="OrthoDB" id="2366471at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="539" mass="59325" checksum="D905FDCDD8688C47" modified="2018-01-31" version="1">MPVIPNTLAEISRLSDDNKGIFPLPLSNAAFTFDSFGIAGFFGGENALAGMATVNLIPGHRWCGWYNNPGSYEIAKRYGALGKLKLCDALFPEGDQDPAHVFKLDGPGGPPFVPVHSGISQSTGQIARLFAQWAADRELYRRERFSGRVGARHDVTIVHLGHIPPGATQYPDLPKSSNFLFSLLPNLVSVGGCVLCALVADWFAFASIAIGIVAHGFACCVIGSGKLEFVLPKLVWPGPGNGVLNGDENMVILIGPEGAVNAVTRSRFRLRYGTEPSQVPRRVQPERGDAVVEDEKRVHNAAPSPKKTGNPPPSLKGVGRPDDLSSTSLPNDSVSSRSLSRWSEHMRQWCSSPPQYLIGHCAILLMLQFLAQLVLIPLSTLFGQLMFIMTVIASWLYSVCLSVSCEEIQTKILLDMLQLQDDDRDVRKYRLETWTATVAFASFVLASSRPLDDAPAFLNGLLPHDTVIWTAWKAWMATKLKADQLNMRPEFTENDLSGMPDKPRRDRLETLFRDVQNAWDAYSAIRPWLLRDQGDSGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLB5</accession>
    <name>A0A2G8SLB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLB5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLB5"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013715139" evidence="2">
        <location>
            <begin position="19"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="393" mass="41449" checksum="219FD73E053203B4" modified="2018-01-31" version="1">MKLSSSILVFSLAMGAAASSFNAKHSACSSAATSAVPGPTVRATKGSNKGASGANEDPQTSLTLLPSVIAHGFENDGQDAPEAGQDPSLTSPNNFINFCATVPSLPLTNGKQIKTGSCNPAPMGVIAAITNMPSSKFVFPTNGAKLKANTDFTIAMAIRNFDTGFFVNPEQNFLAAPQQVDACSGNIKGNSHFVIEQLASLDSTTPTDPRVFAFFKGLNNPADSNGHLTADVPAGLPAGTYRLASINTAANHQPALVPVAQHGTLDDMVYMHCSILHHNSIPIEHEHLKHRRIQSSPLGPGQGFGLQQAWRPRANRVETSWFPGGSTTRMTPSSDHYAVPILRIARMRTKLFSLVLMLQAASLAMGMPVEGRDGTTSSGVSTVSVGEPDWLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLH8</accession>
    <name>A0A2G8SLH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLH8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLH8"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="594" mass="66056" checksum="9B644FCF1D028CD9" modified="2018-01-31" version="1">MPSPQVYRGLVRKLVVGIDVGTTFSGVSYAVLDPGEVLSIRTINRYPGQENDSGNSKIPSVLYYRQDGTLHSVGAEAKAPGMELVAEDENLIFVEWFKLHLRPESLDAGAISRKDLAPLPPKKTVIEVFADFLNYLFDCARRYISETHGNGESLWNSVKDRIEFVLSHPNGWEGLQQGKMRQAAVLAGLVPDTTVGHSRIHFVTEGEASLNYCINNGLATHAMQDGKGVIIVDAGGGTVDISSYLFLSTSPVSVEEVTSPECILQGSTRVNVRLHEHLKKHLASSAFANEEDIKSMLEHFDQNAKPVFKDEKEPSYIKFGGMKDNDPKVNIRRGQLTLSGSDMASFFKPALQSIFNAIQSQRDGASSTLLTAFLVGGFAASPWLYSSLKKKLEARGVALYRPDSHTNKAVADGAVSFYLDHFVSSRVTKVTYGTEVCVKYDPDDPEHFARRYQKFVRPSGTFRLPNGFSVVLQKGTRIREKEEISEWFLQEARESRTLSTISCDVICYRGRGTPTWVDVDPEMFAPLCTIYADTSRVSRQSKQGINGVYYTQEFKIVLLCGLTEMQAQLSWMENGVEKRGPARIVYDDDLQISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLJ0</accession>
    <name>A0A2G8SLJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_03389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLJ0"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027580530" description="Transporter" evidence="7">
        <location>
            <begin position="21"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL34610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44327" checksum="7E241FC35DE6F996" modified="2018-01-31" version="1">MLELRVILLLWLACISWALAEPVAEFFSRPGSSHTNNWAVLVCASRYWFNYRHMANALGMYRTVKRLGIPDSNIILMLADDVACNPRNKFPGCVYANPGRNLDLYGDNIEVDYRGNEVTVENFLRVLTGRVEPSVPRSKRLLTDDRSNVFIFMTGHGGNEFLKFQDNEEISAFDIADAVAQMWEKKRYNELFFMIDTCQANTMYSRFYSPNVLATGSSVIHENSYSYENDYDIGVAVIDTYTHYILEFMEGINKTSQTTMEDLFNTYDPVKIRSHPGVRSDLFRRSLHDTLVTDFFGGVSQAEVLPPLNVPPRPRSTSDEEFQAPTPDAREENQTEVFTSAGDLVDGQAFLTALGHGPTSEVGEPLVRKARTWASTLVVFVLAFWVASRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLU7</accession>
    <name>A0A2G8SLU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLU7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLU7"/>
    <dbReference type="OrthoDB" id="2749985at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="388" mass="41322" checksum="EB5B9CFB62036317" modified="2018-01-31" version="1">MSFAPASSSSYVRGSTPAVAPIAGASSATASGVLNAMTDAQALATAQHEASASAAFVRRLAYNDAVTVADLVLALPRPYQFALDAAIRRIAELAEKRVSIRAAIRRAESADTDGKVLPHLTVKSVQLQPAREYEEAGRWLPIKARLDAAAAKHQADVKAINLEFLKDERAVYDTLLANEAVFNSLRGVAHQRKAELEESHKEPVFEYAHKTGTMDDVVWNKTPSGSSDTRIVDWETSRAVVYEGDNLISDLFFIAARAIAIVEQKDLVLRTKIEKKKEIEKKADTQMEDATRPGPSIQSTIDKAVDGKLRALSDQVKKASRPLGLGAKTKKAKTQKSKATGAGKASSSKATTPAKKSAAASSAKAAGKSKKSAASGKKDVKGKGKASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMZ7</accession>
    <name>A0A2G8SMZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SMZ7"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1396" mass="151064" checksum="153F466BAAA1757B" modified="2018-01-31" version="1">MLSKPESSLIVPVTFSSIATPPSQKTRKGLVDFVQESLTSSSPSCITYWDSHNPVAPSGSRLDSIPAEGVALGCSDGSVFVLRSIGQSGSAPFVTIPSEPVSSPTGTRRYLGLGRPASRSASPSSTKSSLSPFHVTRSRIVSAVSNEQVEAPKNYVDFDEEQEKLRGMLKGKGHTDSRRPSTSRPRSDKDHPVLEKPVQSTSNIGSSLRKDDTMSYLSSALSPTASTLSLSLSGPPSPTLVLGPEPSSPTSFSLRCHVFPPHSGSGRAVSSLKLHEGGKYISCLNTRGGLSVHSTLDGGCIASTTIEARPKPTALTGRVQTVHAMLWVWRTLLVVASEESIILFACASPDEFYPAGQFNDFGAGDSDNYSLLVAYELSLGGEAQIAEAKLESLGDWTIDGPVNSIGLRAEDDHSLTLFYANSSGHLVSRSVRINDALPAPPTLLESHSSSHLPLPNPFKVLKSLSTDHIPDTEKDTVIERVQLADEIDRGEIGLSSHLLGLRGDAGGEDVRLCAWTSNELRVLNWSKSGLEHSPAASIADAQDIRWTGHDTLSVLFPDRTEIHRVIFTPENDQGHRLAVRKIQTEPLTPGDAAALTPRGTVSTHVKHGTRRVLLRAHDAAAEDAKHQTRTLWKGRPGRAPSSSAPVNADVERRITAILPLELEFVVLGFSDGRVCRSSLLDLARGTAGSDVALMSERDTPLPSRIIAMDSVENRRTGERLLVGGAEDGTLGIWSLATLKLFARWTVFTSPLAHMLSLHDEKVGRLCGCVLCISQDGTIAVIALDGYQFVYLVPASAAPLERVCLREDNLMLVYGDGRARLWDTRSREFWRSMSAEKAAEMMQEGDWLNWSLTKSSESKDVLATPSLCDSPDAASTLCIDVSMLLRQFSSSAALVGTNGPLTTKARLEHARALLSLLLTFGISEGIDNICREGLSIVPQLATINFASASGLSLLPQPSPASCWAVSPEVSADRALAIISILQFLMQFEDLVQDASTVMTFYATSVGPLVTESYQPPSLPRLGRHLLQASSAEERQAARLLFDAGVARLSDAETTVIVEGWQRYLPAIQGNTQSESMQSALALCVCGFIAVEKYSLLPTNTLTDIAKSIAGYLHDETSPHRSLGIDLCSRGFQVWQQYVDAVEMLRALFTLATTTKKEAIAVPNIGVQARSAVLQIAASNTPLFITTLAIDILHPRSVQHRKSVMQLVIFMIRKKPLVLYSNLPRLVEAIVKSLDPNSNATREAVLDSATEILSHIVQTFPTVDFHMGTQRLAVGTSEGAVVMYDLKTATRLYVLERHKKRTTACSFSPDGRRLVTVSLEESTVLVWKVGTSFTSFFMPGVPPRQGHSGSEPFKTLNFNIGAAAHMSLEDTLTDVRFEWAGERSVKLMIKDSTLTFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNF2</accession>
    <name>A0A2G8SNF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNF2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="72" mass="7646" checksum="DABB4C739A130B3B" modified="2018-01-31" version="1">MVTKGKLFSDLAHLAHLPATASQVPATSRFSPSSASRVSPIPYTIAQLKFPSPSPLLNDSALASLRARFARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNM1</accession>
    <name>A0A2G8SNM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02091</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNM1"/>
    <dbReference type="SMR" id="A0A2G8SNM1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNM1"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="100"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="281"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL35365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="467" mass="52301" checksum="45832AA650E7209A" modified="2018-01-31" version="1">MEKDADGFYTPYPAAETAAAAPPAEDTAPETKRDADAVTDLIKSTFEVSVTLADQQADPNSPLYSAKTFEELGLHDDLLKGIYDMGFTKPSKIQERALPLLLSNPPQNMIGQSQSGTGKTAAFVLTMLSRVDYSIHKPQALCLAPSRELARQIMSVVVAMGKFTAVQTEYAIKESLPKGATNITAHIIVGTPGTMTDLIRRKIIDVSEVKVFVLDEADNMLDKDGLGEQTLRVKNMLPKSRNVQIVLFSATFPDHVRNFANKFAPNANKIELQRNELSVDNIRQFYMDCRNEEHKYEVLVSLYHLLTIGQSIIFCQHRHTADRISQRMTAEGHKVASLHGAKDATDRDAIIDGFREGKDKVLITTNVIARGIDIMQVNMVVNYDLPLLNERDNFGNKGDFRPDVETYIHRIGRTGRFGRKGMSVNFVHDKATWQQMEQIERATGRQIVRIETTDLDTMEEQMKKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNU9</accession>
    <name>A0A2G8SNU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNU9"/>
    <dbReference type="OrthoDB" id="2554033at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="24377" checksum="1359E714A8F1CE43" modified="2018-01-31" version="1">MSSDEKNFTHSLPIPISEGRRRSGSESDSGSSDSASTSPPSPFPTPASGTLPRIAPPFSPSTSPILSYFLSNQSTSPKSPPSTFPFRRGTTGSTFCEDDDVFEADKPIYSHGRRASAAAWPGHDRYPPAVPAPSDQQERAAGLLRRLSLGGNMARPPVPPIPKQPTLNGSTQAPRSKTPPNLTSTSAAGAPPAVMRKARRANTLAPGTPRPPRAPSPMGERILKGHFDGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNV3</accession>
    <name>A0A2G8SNV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNV3"/>
    <dbReference type="OrthoDB" id="10484539at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="206" mass="22926" checksum="113EBB32BCADE8F6" modified="2018-01-31" version="1">MSLATLKDTLAPGDTIEVEGLTFHPSDTNILSHGVADAMVRVRGGKTVRFDEAQRENDTFVHVASVTAKNAAEGKLIHKGIVLEADYECIYLAATCTFGGSTWLRYKTASVVDATSLPNFIPVRPAEKEEEEVDGNTYKTRDPISKIGGNPNRCVWVYVRWASKIYYSDALKVRISKEKYSAEMVDVIRDEIERHRHMESNGSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP83</accession>
    <name>A0A2G8SP83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP83"/>
    <dbReference type="OrthoDB" id="2757087at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="383" mass="41423" checksum="62DC4F708379F325" modified="2018-01-31" version="1">MFGFFSSRSCSQTAAALHAKILDRTNAADAPPPTPRVARHVVSPGLLNALLGLPEPKSAKHFADVKFVAPSAFYQPKPRPSLTGILSWQDQTEQCSPQSNTSATRKSIIKKILLVAGRRRAEIEDPNAAPVWPPIPELIANPPNRRPRPQAIGLPVPPIGLGLDIALPIASTVSSGHFIGRDGTEWPLPPTECMPRPSLSPIAPPRTLPALTPLGGDKWTTLIATLDTVEDKDAPFFASLHMKHSTRSCSTVATSLPRTPTDEVVLLPVRNAKVECAPRWGVIGDGRPRSKPEPASPPRPFLGASLRLPSPSFMEAEDIYDEDGEESVIGYWSESESEFGSEYSEFEDGDDDAWSINSVYDSDSEVGEGDSRSDFFLASDEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPA4</accession>
    <name>A0A2G8SPA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_02281</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPA4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPA4"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="120"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="460"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="460"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="263"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="354"/>
            <end position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="586"/>
            <end position="590"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="631"/>
            <end position="633"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL35553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="813" mass="88779" checksum="6DE78C28F284F87D" modified="2018-01-31" version="1">MSNATAAKKMKLAVLTSGGDSAGMNAVVRAVVKTAIIKGCETWIVREGYEGLVRGNDAGHHRSHNIGAEKGANGSRSRTPTPEAVETESFTQTLRYGDGDLLRDGTGDHPSGRSLKGRYIVRVGWDDVRGWFSEGGTLIGTARSMAFRTREGRLTATHNMIKEGIDALVVCGGDGSLTGADVFRAEWPGLVSELLSTGKITQEQARNHAHLKIVGLVGSIDNDMSMTDLTIGAPTALHRICESIDNINSTAYSHSRAFVLEVMGRHCGWLALMAGVSSGADFIFIPESPPDADHWADEMCNMIQSHRDIGKRKTIVIVAEGAIDSKLQPIHADHVKDILSERLGLDTRVTTLGHTQRGGRPCATDRTLPTLQGVEAVEALLESTPDTPSYMIGVRENKITRVPLMEAVKLTREVAQAISERDFEKAMSLRDPEFRETLDGFYATSMLESEPKLHHHLRMRVGIMHVGAPAGGMNAATRAAVRYCLRQGHKPFAINNGFVGLLDDNVFQLSWLGVDNWMTRGGSELGTNRKLPDIDLGAVAAKFQQYNFHAFIMIGGFEAFSSLQILEQGRKFYPAFNIPMAHLPATISNNVPLTEFSLGSDTSLNALVDACDAIKQSASASRNRVFVVETQGGKCGYIATMGALACGACIVYTPERGIDLDMLRNDVKFLKRRNEVSSDVYTTDVITKMFKEEGGSLFDSRSAALGHTLQGGIPSPMDRARAVRLSLKCMSFLEQHHELLLKQQSRSKQAPPESAAIITIQGSSVQWVGVQDMVEHADMKNRRGKQAWWQKYTELVEALVARPQLLAKGRPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPL6</accession>
    <name>A0A2G8SPL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPL6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPL6"/>
    <dbReference type="OrthoDB" id="3183258at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="175"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="341" mass="37903" checksum="BF138D733710B5CE" modified="2018-01-31" version="1">MPMFVQEVYGPMFIGVTLNIMLYGVMSAQTYLYFSMYKDDRTWIKVFVLVLFLCDTANTGFDIAFVYDPLVNHFGSLSALTEATWNVFAFNESANMSVVPLDPAITAIIAALVQLFFAWRVKVLTSNRRIVGVIVLCSVTQLLGGLGVTIALGMVPQFYEFRKFRVIGIIWLVAAALADMLITAALVWHLRKHKTGMSVTDDLISKIIRFTVQTGLITALFAMINLALYLTIPSGYDLIFNIPLAKLYTNSLMSTLNSRRIWKAAANHSSESLGHSAQRSMVNVNVLHSDADGRRSIRASERIAFSMESHQMTDFADMKDKVYPSNTASFVPQSAMSLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPL9</accession>
    <name>A0A2G8SPL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_02422</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPL9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPL9"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL35692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="542" mass="59753" checksum="DA69D17135E4FEF5" modified="2018-01-31" version="1">MTTPHVIASSSGHHSSQSATSNGVVGNHFRVGKKIGEGSFGVVFEGTNMLNNQPVAIKFEPRKSEAPQLRDEYRSYRTLNGTPGVPQVHYFGQEGLHNVLVIDLLGPNLEDLFDMCGRKFSIKTVCMAAKQMVTRVQSIHEKSLIYRDIKPDNFLIGVPGTKTANTIHIIDFGMAKHYRDPKTKVHIPYRERKSLSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGGLPWQGLRAATNKQKYEKIGEKKQSTPIEELCEGFPEEFAIYMNYVRKLGFEETPDYDFLRELFTKVLKTLGEPEDGVFDWMLLNGGKGWEASHTSALLASAHGGTPHTPHRDRHRDRERAHRSSRNQLQEGASPASPLVLAPTPAHVKSTRRPHDASRGGSREHVSVQPLAPQSRRQSQAQARAERDSGLVAPHPYAAPGSAGGGYRANANAYGRQSPIPPNGAPGTNGSGALQQHPNNSESFMYGQGAGKPGTASREGTTTAGTRQEGMNSQARMGVYDREQMARVGEQDEHGMGRKKGGFWAAFCCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPQ5</accession>
    <name>A0A2G8SPQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_02474</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPQ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPQ5"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="617" mass="67641" checksum="CFF147D17650D4E9" modified="2018-01-31" version="1">MTLPNTANPVTPLEALLLSRRYLVSQATFCATILLVHVSASWVTEARHRRKLVVPEGEVSSVPRQEGRRTHLYILFAISVTLWILCVRIAMKEAKLGIWQSMSYFEVVASAMFFQFSLYACVRVAHHGLTFGELSLVAFGATVLFMELVNLTKAKLWPLTTPYIKTFRLPTPLLVFQIALIPGSLLTGFLLSPLLYLSRHIAQRPVRRLRYPQEKQKHRRLLALGFYSGTILIVGGLIGLWTRWCLGGRDPWVYLIFWMLDGKNKWTRPALAGYWALLISLSVAGWTRQLARSKRWRQWNVRGSMQATNGTVAETLSAPTSPRYGMMPGQSGYGGTTTIQSVPQQSASVGAGGPAELSDSTSTAPGEGISGYGIRLPNLPNLPNLPDMPNANFANVATDLLDAADKRVPTLSVNARRKFFHALAVVMFVPGIAVDAAFTHLAFSGAFALFTFAEYVRYFALYPFGAAVHLFMNEFLDSKDGGTAILSHFYLLTGCANSVWFEGPSRLLQFTGTLVLGVGDALASIVGKRLGRHRWFAANPKTIEGSAGFVVSVCACGWLLRMVGTVENFSVVRFAVVAGMAGGLEAFSVQNDNLTLPLYMWAMVVLLDVVDESGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPV6</accession>
    <name>A0A2G8SPV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPV6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPV6"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="76"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="118"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="425" mass="46834" checksum="A80FF6B26348C30C" modified="2018-01-31" version="1">MMAGIQLGGRDRDFEFYDFLQDKTHLQPLVRSIVVDPMDFAPVPLLRTLSNLSEIKFISQRPIRALHQSTGLTFLPEGHDTSVRALVISPDSTWVASGSDDSTIILWNTKGTLIRQWVAYDYTPILSLAFSPDSRHLVSAGEDSKMVLWSLDRDACNTTIDLTAHADTIVWSSNSNVIATALWDGTVQLWDGRTLESLHVLLEVQDANLPLVARCLTFSPDGRWLVLGLSGCNYCVYHVQSGTLHQYIQGLEVPAFRDAPTGPLASFAAAFDPTSTRLPHTSGRDAVEIWDIETRSRISLLRYPALANDVSFSPDGRLVLAVLLNRTVCVHDAHTANEVLLLEGHKDRVAKARFSPCGTYIASASWDRTVRVWKTSDGSHVATLSEHDDRVEHLAFSPDGKTLSSGGLDGTVVIRRTMSSDIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQE1</accession>
    <name>A0A2G8SQE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQE1"/>
    <dbReference type="OrthoDB" id="10525492at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="207" mass="22306" checksum="1CC55AF5D865F9B8" modified="2018-01-31" version="1">MAAGATIAATMTHLSDATDYVVQLQKLLKATEAALDTADKLKTSGNRWIKLFRPVLTARAHYKEALSVYAAAIETITPCIDAMDPEDAFAFLMMANAILDLRKTIYENKSYNRKLCVKLLGDAHVLRENAGRSRDHLELQQLSRKIKLATIADESQVGTAAIVTNGMATSDSIAYSGAASRNPFVDPRDPAGMTNPDASGSSTQISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STI5</accession>
    <name>A0A2G8STI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STI5"/>
    <dbReference type="STRING" id="1077348.A0A2G8STI5"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="86" mass="9618" checksum="D302ECF667A6C230" modified="2018-01-31" version="1">MFRRRTVYILLSLLAAVLVGTVVVLSSISYYLSIDVAAYITEDEVNLALNDPHDALPERVPRIIHQTWKSETLPQTGPISRKVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STL1</accession>
    <name>A0A2G8STL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_00797</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STL1"/>
    <dbReference type="STRING" id="1077348.A0A2G8STL1"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL37105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="11504" checksum="41DA8961B07713A8" modified="2018-01-31" version="1">MARSNTRVGLNKGHPTTPIAKTVRPSQRKGALSTRNKFVRSVVREVAGFSPYERRVLELLRNSKDKKARKLTKKRLGTLLRSKRKLEELSNIIQESRRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU42</accession>
    <name>A0A2G8SU42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00945</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU42"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU42"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="384" mass="43667" checksum="5CFF3969DC413067" modified="2018-01-31" version="1">MSTVTVAASCVPSPPPTPSKKAAAAMQKLDIATSQQPVASSSRRFVGDVNLPEHMEPLLMESKRRFVLFPIQYHEIWQMYKKAEASFWTAEEMDLSKDLHDWHNRLNDDERHFISHVLAFFAASDGIVNENLVERFSNEVQAAEARCFYGFQIMMENIHSETYSLLIDTYIKDPKQREHLFDAIDTIPCIKKKADWALRWISDKESTFAERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGMHTDFACLLFSHLQRRPHFDTVRKIITEAVAIEQEFLTDALPVALIGMNSKLMRQYIEFVADRLLVALGGEKHYGVTNPFDFMDMISLQGKTNFFEKRVSDYSKAGVNASATSATAEVSTSKTFTMDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUE2</accession>
    <name>A0A2G8SUE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUE2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUE2"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000002">
        <property type="entry name" value="Prefoldin subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14280" checksum="2AC2FC298AC20A02" modified="2018-01-31" version="1">MSSSKTKSKAPQHKPSAQEIQQQYNRFQNDLQILASKIGELEQEAEEHNLVLATLDEALTDEPNRKCFRLVGGVLVERTVKDVVPALKTNRDGIQKVIGNLAEQYKGKDEEFENFKRESNIRPASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUV9</accession>
    <name>A0A2G8SUV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUV9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUV9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="170" mass="19432" checksum="CE579C7338563B0E" modified="2018-01-31" version="1">MDSPKATRRLTVGRASNTVYNARSIYENTSPQWDLGELPPKLMYFEPTVHYELNTTAADAEWVALFPYDGIVRIGEDREPYTISMFHQLRCLDVIRRAYIAREGLTPEGPSAVSLHCLQYLRQMILCRRDLRLEPVIDTEGPHAVQPWGTMTCKDWTAVYAAQARNARGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVE0</accession>
    <name>A0A2G8SVE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SVE0"/>
    <dbReference type="OrthoDB" id="2751143at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="471" mass="51741" checksum="E3141FEA061D667B" modified="2018-01-31" version="1">MASNPAASILSQARIAGPFSLVIPPTTYCPGSDVEGEVLLTFPKVQEEKIDEVVVALLGNLKASVVVSHGNQRRSISERQELVSLRTSLWKRGSAYPPPGSHVLRLPFRFRLPSDPKLLPSIPSNAGSESASIKYYVEVIAHRPTVLFGAEDKTMRRQLTVVSRGDPGLCASIRSLRGLSAEGGPTWKTVHKEKKMRRGIWGEYSTARVERAQQSNDISPGPLAQLLIPNQHGILPTCIDIPLLVTVKTTTARLSRAKAHKHPEGQGKPVRVFPAIDFDTNDRRFVSLQQAFTVRVRGHTRQHTNEIALAYIKPEDILPSESAYYKHWQADTAAGDRPGEEMGRWVQQWTLQRSVKLQRFPPTFECDFVDCAYVMSVRVPFPGLGNDIEVSTRISLDSGIDHAMPQKNGRATRRVPSATTLTEASGPSASGLGTDVPVPLAEEPQSANPPVRPPTYFDAVYRDGRVVGEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLL1</accession>
    <name>A0A2G8RLL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLL1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLL1"/>
    <dbReference type="OrthoDB" id="2310204at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013694833" description="Transporter" evidence="1">
        <location>
            <begin position="25"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33101" checksum="794C369CD47AAF68" modified="2018-01-31" version="1">MASITATAAALLMLLPSAPTLSLAYTPSRVRSPSPLWRRASSSRSVPPAGFYNPAANGGEMLTVAPNTGGLGEPLNVIVSGNSDELVLADNEDKGGFRNWMISVGFASECLGQHAGDAQTANLGDGNGQLNETSELRWDYGDPNLGTCKETINGGNHFRYWIQDGPSGNSGAFFLATSYEMPIQDGHNIVFDGYNLGRDWLVGNATAQSNLIPTGNVTNGTTYSGKTSFGNYTYSTDAVYLTGILSNSTSGLNHASSVGGNGVEAVDGLVAVLTVKVLSTPTASASGALPSLSTPWWPLGATLLLTTLTLSQSLLSLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLZ1</accession>
    <name>A0A2G8RLZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_15211</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLZ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLZ1"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040909">
        <property type="entry name" value="CHFR_Znf-CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17979">
        <property type="entry name" value="zf-CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL22522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="543" mass="59087" checksum="6CE0246F8957AAF1" modified="2018-01-31" version="1">MDRPPPDPALPQHRARSGPIALTVPVQVQEASASATAPLKRSASEAFEDASDGEATHKKLKDSDGDAKGEDGGPNPDGATLADSLEEELQCGCCSAIVYRPVVVNPCQHFFCGSCITLWIKNGGTSCPACRTLSTSVSFSRPLQKVVDTLIRYAPDKARSVSERMQADALYHPGVHLRIPSPREASPEPALPSANSIYVRPCPNCLQGNQWGWRCPQPIVDPDADPNNAWLADDGNPPGHGVCGNCENILALQAPTTTRCDFCQVSFCGINVPQRCVACPLESQQPQGFSDIGDLIQSGEVYECFDGNTVEVDLMLDYLGAQGLSPKHIYKEIVQHIQNQPRQFALLIEQEMFMDVHPVASGIDPDPRAPRRRICRVCAAEILLFGLREWWVRERKKGFLEPHVLARPDCPDGSQCPRQKSHAHAKEFNHIIAPPDPQPAPEHAPQPVPTREPIMRSSPDFPPPAPAVPQSVQEPPREPRAGPSTIAAVGPISRRLLPLMDDLPPPASFLPFLVAPAEYPVDLPEFGAAPSSQDFRDEVDALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM24</accession>
    <name>A0A2G8RM24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM24"/>
    <dbReference type="OrthoDB" id="437973at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039715">
        <property type="entry name" value="ZCCHC10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491">
        <property type="entry name" value="ZCCHC10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13491:SF0">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13917">
        <property type="entry name" value="zf-CCHC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="172" mass="19188" checksum="CB7951A651A1A30D" modified="2018-01-31" version="1">MSKYAPHCSASSNPRASTTTVCQKCLKTGHFIYECKGSRPYISRPSRTQQLENPKVLAKLKADGKPSVEVPEEFKSKSGTANRILEEKEKERLKNQDKGEGSSRKRRRSRSASSSDSDSDSDSDSDSDSGSSSDSSSASDSDDSRRSRSRSPQRKRYRSESRSRSRSPRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN66</accession>
    <name>A0A2G8RN66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_15452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN66"/>
    <dbReference type="OrthoDB" id="2734101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013661383" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL22758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="15085" checksum="3E586CA8C298ADFF" modified="2018-01-31" version="1">MKFVLALVAFAASALAQHIEIGAPNNFAEVKAGSKITVEVAQPNSLTASTEVGIAIGLWPCGGPKGTSKCASTDVSQVLGNVVYTGSYKSESDSTQPSKPPHQNFEITVPSSFSKGEVSLGIAHLFLVGAGSEPVYEFVNTTLVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP43</accession>
    <name>A0A2G8RP43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP43"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP43"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051981">
        <property type="entry name" value="Glycosyltransf_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042:SF21">
        <property type="entry name" value="ALPHA1,4-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12042">
        <property type="entry name" value="LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50513" checksum="F2E4A24224E0078E" modified="2018-01-31" version="1">MSRPEENLPLYSGRDSPTLRHRSPRPASPSRLPLPRKMDYAVRQLLRPHKLLAFLKVAVPVLIVAVVVALLYWEPHIEIAVYNRAWVKQEVLTVPPLGGCFSPRAVSPAYNFTDAIYGARRTEVHAGTTLQFGMDCYDFAGTVRPLDLGPPAHPVPGEKRVQYHTYWRTDLAPFGARQEWMLKSFFATQDTARAQLVLWSNGDLSGNAILQKWLKKYPEAFALRVVDYAELARGTELEGSALLRVNDAKAWIDGDLVRLLVIWAYGGVWVDMDSLLTRDLAPLLEHEFVTQWDCYDKKYVPMNGALMHFRKHSPYLCEAFHIMVTSPPPRKGTTDWGALLYLKLRRRLLAGGIPPFKVLPFCFSDARSCRLDNRLPDPFTPDPSDGRWTMGYGREEGGGLDSVLKKVFSLHLHNQWEKPYPSGGWVERLLLRRYEREIGSEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPA1</accession>
    <name>A0A2G8RPA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_14665</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPA1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPA1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="524" mass="57460" checksum="E3C645B8FAF35937" modified="2018-01-31" version="1">MSFSVIPNSSTVALTLGIAALLYIVRWLADKGRYDTKRIPSAAHWLWGHELRTFHGEATEMYTKWAARAGPLFRLKGALFHPDIIVAADHDAVQHIFQNVDDYVKSPAFRPPVANVLGKGLVWAEGDDHKTQRRIIAPAFSSEAIKGMADDISECSEKLESRLTNHILSAGGAATVNMLEYASTCTLDIIGRVAFGHDFKAGQSVEAKEIHASWEGHVNTGLGFSGFVAMLVMRALPFITVVLTKLPVESIRAGGRIREITTKLSMRLLESGMVNEKGRDIMSILVKAEKREGSKGLSPQQIVDNVNTFIMVGHETTAGSLAFTLLELAKNPAVQQRLRDEIRSVGRDLNYDDIQRLQYLDAVVKEGLRLHPASPQTERVALRDDVIPLSKPITTASGETLTSIRVRAGQVFHIPFTTMQVNTEVWGPTAAEFDPARWLVPGGVPPPSELPHGWSGLITFCDGPRNCIGYRLAIFEFKVILATLVRGLEFHETTAIVHKKISPTLQPVVDGRGGLLPLHVTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPX6</accession>
    <name>A0A2G8RPX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_14870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPX6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPX6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL23557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="541" mass="59867" checksum="523CF4B1E65B9E1F" modified="2018-01-31" version="1">MLLQAVLLGGFAWALWQIIWPFVVKSPLDVVPGPPSKSFLSGNLEQLFDRDAWGFHDEVGQNYGPIVKINAVLGGKWLYVFDPTALRSIVLKEQGTYDQIPWLIQSTRMLLGPGILGVLGEAHRRQRKMLTPVFSEANLRNLTPVFYEVAHRLVEGISKNLQGTPKSVDMLDWMGRAALEIIGQAGMGHSFDPLTSESSSDPYTKAAKTYLPLSFTPAMVAMRQASPILTSLGPAWFRRLIVNILPIPQVQQLKHVVDVLHGASIQIIGDKKAALVNGEVSKDKDIISILLRANMAAAEGERLPDEQIIGQMSILLFAATDTTSHMMAQVLELLAAHPDIQEKVRSEILASRGGQDVAYDQLQLLPYLDAVCKETLRLYPPTPIVLREAFQDSTLTLSEPMRSSDGSMVDSVFVPKGTNVLVGVRACNRDRSLWGDDAEQWKPERWLKPLPKAVEAASIPGVYSHLMTFVGGSRSCIGFKFAQIEMKVILSTLLANFNFELSEKPIVWNVSAITFPSISKESEKPEMWLKVSRCNSDDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPZ1</accession>
    <name>A0A2G8RPZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methionyl-tRNA formyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPZ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPZ1"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="1">
        <location>
            <begin position="30"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31232" checksum="C37D2944F7A9F210" modified="2018-01-31" version="1">MAERAGLQVYTIPEERSKFKTWQVPPPFKSDLAIPSDVSPFSHHLLVTASFGRILPNSLLNLFLPTRRLNVHPSLLPAYRGAAPIQHALIDGQQETGAVPESATFRTLRDSLAVTGGQLLVSVLRDILAGKDTRTPQPEDPDAPRAPLITAEHSKIDFRTMTAARIVGTHRAISHQKPVTTMLKIGRTLQLHNPSVFTGQHSDIESHLPVEGAATYHPPTKTLVVRCAENTYLRVPEVRQQDRRLLNAKQWWNGVTLGMRLTEGTEGPVHFIPFDSTSAIKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQC7</accession>
    <name>A0A2G8RQC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_13464</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RQC7"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1429"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="213"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="438"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="700"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="813"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1198"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1720"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="459"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="547"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="840"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="880"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="966"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="985"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1072"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1121"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1141"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1198"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1230"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1259"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1277"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1739"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1783"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1811"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL23714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1828" mass="196906" checksum="48917B6F553931AE" modified="2018-01-31" version="1">MSSPPSPTIGQVAHEKGRVKRRDRPPALDIADPKPGLDGDVRYGRDVANDSRKPFLQVVPADESSTDVETDVPRSASATSSLDPYYFGVHTPSDSPIPPVPPVPSVPKTPEMRHYEPVTPGRDPASIDRRTLVGVGELATPRWARGVRNDEYEFVTQERVDEVNEEELVEVGGPEDDRDSDSPWTIEAIDGEQDDKTELMEVKPVARTLRSRRSIAEESGGEEILYPRHPHVNSSDVSPVPQLPSHFQGDSEGQAVLASHIVGEQAPPSAFAIPHQRPRKRTSEEFEMEHGVLVSKFTPPNGTSSTVKDKDKPRRHRSLGGGAPPQQATPKEKVKDRRRDTLSLSIRHSRQGSSSSSHGESHHPRRAHNSDFSHLPPSPSTSSIQQFLGRAGTAGSSTSSPLHTQPHVASNVAHSLLRGTQEGWSDLDDQTTLEALRKLDGLSGKTARARSSIGGHSRVGSSSRPGTPAKATTQWEGIESGGSSKRTSIHASLSGKDKDKGKEGAHRSISGPVPSATDGPADTDYVVTSGDDIHHDSPQPDKATKKAGTTSARSSFTPKRGSASSGTYASTPTTSSRDSASLSVGTSNTSVSAVSGRQSSGKVKRNSTSSDISIGHLSDPTTVRDRAASLVAPADAPEESFVPPVPPLPKELSSFKATLSTPGASHAPIVEYHSDVPISDRSRRETFNDVAFPTTLDVPVVPTTPSKHTSLQVPKSTTPTNLHKTPSKKWSFSGALGRKLSSTPSTSSMKDAAKSSAASTTSPRAMSFGQQLRKSMSKEKPLSPASKVSEDWSPINSDAMASATSLASLSSLGSGRAALSPSSGIPPTLTASKTPDRLVSSRTGTASSGASTHVPPIPQNVPLSPSSTMRRNTSTKRLTPSSIPFFRRSSSQSMQVPPPSIPTTSVSPTLSSGPASGTHLRAPTTMSPTKDSNLSSPIVSGSAKKSSVLSLGLPSLLKGSSSRRSLHSDKEKDVKSSRESAATSSDREKPKKEDKDRSESRISVLMGRKRGKTLSSAQQPPKKTEPVAMPPMQIAALPASTAQRVANLKSSQPSSSANANANASSTKAGSSRATSQTVSSMQKQSDTSLRRHQLPTIAGSPSVTGNTQAVVRETKEGPPLSSLNLSTVLSKETPTKIPRISSRSSAVNSPTLEANGTSRRASMIIGSSSGITPSRGASPTAGSESMNEFGVLENGQVSASKTVSTSNSMANGSTIPRKNRDSLSFGLRKASTGSVASTTSGAHDQPQQSAHSHHRFSALSPSKGLKLLSPKVSLPSARSSNNSTPSIHQTMGTPTGSRQSLSTPSPVPSSVDEEELLGDEEMMQYIKRQQAKKLQSGSTQEDLDAMLRFPEPIPPAPALSPQAVLKSDQARWLCEYECKEILDYESVYYVGAHSEKKMATPDNSTNNYGYDDERGDYQVINHDHLAYRYEIIDTLGKGSFGQVLHCRDHGTGESMAIKIIRNKKRFHHQALVEIKILDSLRKWDAEEKHHVIKMTEHFYFRGHLCIAMELLSINLYELIKANNFHGFTTALIRRFTSQMLQSLLLMRQHRIVHCDLKPENVLLRHPAKSAIKVIDFGSSCFEHEKIYTYIQSRFYRSPEVILGMNYHMAIDMWSLGCIMAELYTGFPIFPGENEQEQLACIMEVLGVPDKDFVNRSSRKRLFFDTTGAPRPVVNSKGKRRRPGTKTLAQALKNPSDEHFVDFITKCLMWDPERRLKPQAALRHPYITGGRRSKVPNPTPSSTAKTFLQSASSNLGSRSTKVTETPKKSLISAPTPLTARTSRTLTVPTTPSGSTSVHSTLGSSSRSYRSSHAQQSMSSYHSSRTMTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR97</accession>
    <name>A0A2G8RR97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR97"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR97"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="332" mass="36388" checksum="4B621536B1B8B51A" modified="2018-01-31" version="1">MHPIAQKILVVGGNGFVGSAVCRTALSRGMQVVSISPSGRPWHTPKGHTPAWVSKVEWHKGNALEPETYEHLLSDVTAVVHTIGTLFEKSGYKSALKDGNVPRFVSSVAAGISGNKMSANPLEREQKKREGSYEALNRDTALRVCETFLKSTPTVQAIKPRAFIYVSAEDCNRPVVPSGYIKTKREAEILIEKMVQKHPEYRSVYIRPPLIYHPHFRPIVSPLAALLDLSATIHAKLPSVFPTPGAVLRTLGSVMPRPAWARESLVDSPFDSMARVLTIPPIHVDHVAEAICIAADNSRTDVHGTYGLEAIRQLIGYYQKGQKGQQRAGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRL8</accession>
    <name>A0A2G8RRL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRL8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="145" mass="16083" checksum="397C55FC8C7AD88F" modified="2018-01-31" version="1">MARYRYEHLSAPRPQRVKWTFAGRRRLSPTSSGNQWHAEEEEVKSFCSGFLWIGWIEVYNVVVVAAEAITNILAQACFPKIEVPSVSLAVLPELLKPFTLTFGFSVATLRTPNYEGTGSLYLRHSNATSAPSSSPPPTSSSSRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRM0</accession>
    <name>A0A2G8RRM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRM0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRM0"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="135" mass="15325" checksum="AD014D9473BBB48F" modified="2018-01-31" version="1">MHVTAWPDDIPEVVPLLQRLGTIHPHQDTQTHIIHLASDGVILPHVDNVEASGTWILGVSLGDERMLRLESSRSPQERYELPLPSGSVYIQRDAIRYNYKHSILHPDGAAHRPRGQRLSIMLRDRLTLNARHEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS10</accession>
    <name>A0A2G8RS10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS10"/>
    <dbReference type="OrthoDB" id="3270460at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="307" mass="34230" checksum="239ED8DB276E2481" modified="2018-01-31" version="1">MVHGNTKGSKRAPTRSPSLEQGSSEQIPKKPRMMSEPWDETLPSEDELTPSTVSDKPEASGNTGDNELDGKEPALIPGQIAPDAFQTYDWVTETKKERLRTFLNYEDAVNVRYAVCKVPPDAGWGTSGAAAKTWRHNGEAVTIWIPGICATKWFVDIKGVLPNRVNIGVMPLRDMDNEAALKLLRLCEPSQEPKAGPIYAGKLMSQWVKDDTKPAIMPFTEIYDAREKFRQKKLMRRLPQTTIGHGDIVLIECNLTRFKTAETKDKPEWTEWHTVFELISVCLLEEAPTGTPLPVVTAVKDATDISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS56</accession>
    <name>A0A2G8RS56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS56"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="149" mass="16090" checksum="0456620BCD69B4DD" modified="2018-01-31" version="1">MLAAVCVKFTRGTVQIFRSGFGIRDSAINMQRTSANANADAPSVVGQWGLGSESYSSNGQGGLILRTPLGGEWCETWTADGRSPERTRKADTGNETRRGASHDTARHDAPSEVKCAQDIRALTRNRAEARRSGPWRAPDWGPTSDRAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSM7</accession>
    <name>A0A2G8RSM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_14256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSM7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSM7"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013950176" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="65"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL24501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="511" mass="53160" checksum="ACD2AE845531101F" modified="2018-01-31" version="1">MRGILASSVALYAASSALGALIPYSGLKARGYSTPLADCLQTAGLDPVVEGDAYAAHSAPYNLRLPWKPAALVYPRDSKGVSAAVNCGAKTGVKVNARSGGHSYAAFALGGEDGHLTVSLDHLRTLSLSGTKGTFGAGNRIGDVALFLWENGTPSLPPFREALIVRRPNSPPSLTLTGKRALAQGTCPYVGIGGHAGQGGFGLPSRAWGLLADQITSLEIVTADGTIRTASKTENADLFWAATGAGASFGIITSFTAETHAALDSVAFAYTFADYGAAEASAGLQAWQAFANDPVNKLDTAVGLQIHVNPGSSPSDIVFSVSGVYYDVEEATVNATFAPLLAKLGTPTSTSLQKQDWITSVLYLAGANTTAQLSTTLAPDMHATFYATSTFVPEAAPMNQKASDALFEYFYGPGANTNIAWYAIFDLFGGGDSVITRADKDTNAFDGRDALYSIQYFGMIPASVSDADGIAFVQGMKKAIESNQPETQFKEYGECCAASASASTGVGECWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT63</accession>
    <name>A0A2G8RT63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT63"/>
    <dbReference type="OrthoDB" id="2794493at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="919" mass="101485" checksum="940CC1701F37D733" modified="2018-01-31" version="1">MEREVARDGVQATPPHSPNAVPTSIHSAPPQSALPAPPQTALPAPPLAALPAPPLTALPVPPALPTPLDAVAQPSRPKRRLAGKLAHQMDNVKAPRVDEFQKNPPHVRVTEDYELSFQDGRTLPKDDASGEPQRKVAIHTFDGIEGVPAYNGFWVESSLQRELDKHNKSTSQSVRKDPIYALQGVTAALAKTVSWIWPSPSPQPRIVPASREVLNLLKLMRQHERGEADLISDEEANAMWFEITDEERFNVLQMYSKCTAKAQIAASEAAFKSLPTNHILAPQNLTAWPAPQPTRVSQHPFAVTQGLNHPGGSTIDTGSHQQPLRTELANPPDVGAGGSSPGGSRASAESSSAGTSLPPEPSQVSTGSSAQGPSMPQDPPPENWHLGCDDPMSDDGPDASNGNVQAAPQVAQTQPSTDRQPMGSNINVLPFDNDHFAFEHEREDLSTPYQDKGKARAVDHMDTSGEAHYMPPESPLVHPPPSLPPAAYEQPTPAGPTPAPQAGTGLGDQSGNLTGGIIALLFNELRTLNANVRENSKLQREAIDAILGLQSDNVQSTTPPGSPGPSKSSQKNSRRTRTPVQTVRERKLNNPSLRARKKQKRVTERVSRWQGEEGETSTDEELVESDDFTRLKARVRNLLRSMLGIDDWAHSAALFPTLTQEQIDEFDEGKLECSAQKFFIDFDHSWAKFKPNRVARQVFLDHYFARVTGGAYAKNPTPEHLLTREVVGRVLDKHMPYCRRLWRESKRPLSKVKKDVIKARAAKNSRKSSIHLARSIVVRRHGDLCHVQMWLLLEPGNMDGDEPEGGQKKKFPVVFNILRPKWASQELCNYWWSLDAEYRTHYGNPTHERATRGNPPRDRVLPENSVEDGVVPFGLWRNCYDQEWLESLQPHLRQELEIIAEDFDFKFAVEPTSRAATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT76</accession>
    <name>A0A2G8RT76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT76"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT76"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="355"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="473" mass="53243" checksum="9FE9532C6769EFB6" modified="2018-01-31" version="1">MGGEFEVSSLKNLLNLWLDNRLTMSGLDSTFSAAFTHYSALAINVLGRQNLSNARWNVEVAYNTSNAFYQCFLSKEMMYSCAIWGEEEHGVRGDLTVGPTAGDLEAAQCRKIHNILTKARVHAGDRLLEIGLSWGAMAIEVLLPQAALLGCTVDTVTLSREQMEMVVQRSLEAGVSDRVRVHLCDYHDMPASFEHAFDAVVTTEMIEAVGPRYMHQFFQCMDRALKPDKATMVITATSQPEFRYTDYQYMPNHGITGHSRGDHGNPEDNCNDVGIYPTTEMARCITHFIKRGVTWSRRKQEVEESSFGRRSWYWMAVLGQVKSETNRTCAFNMVPDALLPPDAAEAAEPYITGDEQGEEGLGQLAEYMHNLLTHQHRCFAYGFYVQGKYARLLYFDRTGALLSEAFDWSEPTSLLHDFVWKVAHMTPEQLGYDPSAQVASESDLDLLRSKMACSELETLPAEVQQYVLRRSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTB8</accession>
    <name>A0A2G8RTB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTB8"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="364" mass="41098" checksum="40934FC5A8EB07C2" modified="2018-01-31" version="1">MALSTFWNHSGELHQLEGFTQSIKHWEPGEPLEDIQQVLLQQLENIFGKEVVLEVEYSDGHQAIVRMPTATSNSDGDIVQDLSWFTREVALLQWLEANEVAIPVPRVLATVHGSESEPYTFSVIEKMSGDCILNVFGALSFDIKESIIRNMANFMLRLNSVDVPQQIGSTAVRGNALDLVPLVPISLTITYPRVFDTLEEYMLYLVQLKRESDSVGSDDDCLTRANGVLDRLLEMLPALLQRLSSTVYRRCVLNHDDLNEANVLVNSDGDITGVIDWEYQSVRPVVLAAQYPCYLRYDGIYHDPRFASVIKAQNKDYWHALVDGELLRQVEEWLTDRNPDPGCAALGRWMDEAFASQPPVEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTH5</accession>
    <name>A0A2G8RTH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTH5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTH5"/>
    <dbReference type="OrthoDB" id="3271284at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="690"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="572"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="884"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="961" mass="102584" checksum="A2640633BA6F686D" modified="2018-01-31" version="1">MDVHRARSPPASLARRPIGPRSPGKPGSLPVKNIIPLDLTTRLQSDEFGALPHTSSPESLSTGSDSPRPESPAFSSPPVLLQRNASAPSGSTSPRHAEDNTSLRRAESARSDRLRVVQEDGGASSRAISGLPTEAGKEEAGGAGTPAKAVTIGDVTTLDSDAPSDSPHRASLLADEAHLPPPPAALGERTPTPPAVFSSPAPEVPPPETPPATSESRGEFTPPPPPLPDHLPPDDAVAAGTFSSTTLVQTNPIPPPPKPASDLPLPDGSMHAVPPPYVAMHADLSSGVSLAVDIPPPPLVADDPATSVPLPPAVVPVPSEGESGPTSPWTDVSRPQSTQSSQVHDAVGRYGVETVNAAHRASGISPVDLLRHQRTMSEKSIQATTVTSDRSSTPASTSRASTPALLKMMPRRPPLAPLPTVNFDSEPVRWKALTLEAAQWTFTSEQLQEIVSGAIRQSAAESFIRVLPTQVADAELPQEADRLEQAQYRFNMHRRAMLLQSLVALSQSPQSDSDGEPLYNLTTQLAELTASCDRLLETLVRIADQKAQVAHLQDLHIASALAMALRKLNASYAKRSAELQETRARNDELKAELEEAWNMAQDMAQEMDDLDNFDLDFTDEEFTPDRDDRRNSHLSYRDEHDDEDLSYSALEAEIHSDMDRMSGISSMRNAKVVEITGKAVATKAVMLTSGAPALAPPNSGDRASRVIAAKKRSSRTSKASLRIPKTPTDGNGERRERPDRSSIYSIRRRRSQSRSVRHAGGRNGEGGKEAPEVPIIRLPEPKSREASFLELSQTRPGSPAASNSDIPPPLPPKEGSSPGLQMNIAASRSEEVLPTQLDSAASSSSPTYDELGIPTISIAEEGLGPLPSEAKGPPSSWRAKSFFNRRTQSMQPSSRPADDDTAAINGKGHSALKRSASEAKQFDGWPFLAASKSHRFSVPVLSVIQPMKGRKSSDSDPAGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTI9</accession>
    <name>A0A2G8RTI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTI9"/>
    <dbReference type="OrthoDB" id="2745177at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="273" mass="30543" checksum="097BC88145AC08A7" modified="2018-01-31" version="1">MDCRPVALDLALQAELEPVANALSSEAVTQETFAAIVPQLVASWQAEQRQILQSFLGRFIKSVPSNVDILDLAVSIVYTGRSVYQNVRTIRYPYILAQGFRHSKPDGDRDDFPPSHYAAPAAGPTRRRPYSLESLKPKQVEVDIKWMRSILTKLGLKPDTATLSDLEQCNACLRCLKCAEEGQGQERAYTWEAAFSHTAQHDTTQLDNAYPRSSHVRWARVGEADMIKVKEREAIAHALTADSNCQWSCVLCVDWKGCGGEGKRRIREHLASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTR3</accession>
    <name>A0A2G8RTR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_12788</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTR3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTR3"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="9">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="240"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="658"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL24901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="730" mass="76356" checksum="89099338C3DDAB04" modified="2018-01-31" version="1">MAPVVLESPAVNMHNSALSPMSRVQFNGHIRTPPASDHSRNDDDASPLITPAPLPPAQARNTASPFPLDPALKERIGDNGDPVADQNNPSAISELACTNCGTVTTPQWRRGDDGKSICNACGLYYRTKHVPRPLSLGRTSTLQSATHPNAKQSVQPSPFQSQAQAQAPSQDRRTSSPPTMPTPAASPALHQTKNQSAEASRAAQKHPGGTCPGDGRCDGTGGTSACNGCPTYNNAIQAGAIEPTNGQPPVQKADPVPAGPEQGGAETSGAESSPVISSQTPGGGNNRSRVRSQVGALSCANCGTSTTPLWRRDDVGNNICNACGPAVELSPEAVGVGANMLHFPGVMALDALNLLSESLVVLELPLTRCTPSTFPPAWHTAGLYFKLHGTHRPNSMKKTVIKRRKRVPAAAGAPSSPTPQDRMTDQAAAEVLASVGRALPSGSAGAQTESEEEQPKKRARRPRTSKARDKDAEGTEMDEDEDEGKPRKARRTTGGRAARASREGSNVAQAGQWGETMMQGMGEPSGSQHLQQELDRYGPGAPRGNPFPPHASQTLPGLIATLGPEVLTSLMNTQYVGVPPPPPSSYIRSGSAQGGMGGPGVPSRAHSPVAQHSMNAPHPPEHLIEGVPTLADLDHHYRALAEERKRLEEMLERTDRMMAGVKRGMDEMRAAGAEDGSQPSGSQQPSQGEGSSVSASAPAVPLASREKGNKEGATVWHVSSPASQPAGARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTT7</accession>
    <name>A0A2G8RTT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_12800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTT7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTT7"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL24913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="315" mass="34416" checksum="EB15210CBCD193F7" modified="2018-01-31" version="1">MSSDALIDSNLTDLRLLSRGKVRDIYATSDPDLLLFVASDRISAYDVILRNGVPDKGKVLTKISLFWFDKLKHVIPTHFVTADVDAMPSEVRKHKDVLAGRAMLVRKAKVVPLEAIVRGYLSGSGWAEYKKSGTVHGIQLPPGLVESQKLPEPLFTPSTKAEQGEHDENISPEKAASIIGADLCAKVEKAALQLYKEAADYALTRGLILADTKFEFGLVPSADGSGQEELILVDEALTPDSSRYWPADTYKPGGGQPSFDKQYLRDWLTQAGFRKGLESGPEGKEGEGWVMAGDVVEGTRKRYLEALELLTGQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTZ7</accession>
    <name>A0A2G8RTZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_12867</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTZ7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTZ7"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="11">
        <location>
            <begin position="60"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="10">
        <location>
            <begin position="225"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL24980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="369" mass="39832" checksum="559544BFC9A400A4" modified="2018-01-31" version="1">MGYAQRKVATTASKLAHVSSSHLKALPPRQSLLSAGRAAPPTVFDAESWAASQPPPQSTLATFAHRVGLGKVVPSPEIIQQACTHPSFVQLHNQQHPDQPLPATNASLATLGNSLLGLFATEFVNSSYPHLPTRVMKAAVSAHVGPTTCANLAREMGAMPILRWHRSPGSSTQSAVLHSDALASVPRALTALVYQYRSLRSARRFAEKFFFSRDIDLRGMMKFRDPKQTLLATVAKFGRERPVSRLLKETGRFSNSPVFVVGIFSGADKLGEGFGSSLKMAEYRAAEDSLLRLYLTRQPPHLVQLPTSTFPDALGNVFEAKGPESPYSPVSLGDSEVLYGSAGRTGVRTPGARSRAAEAAEDDLEDYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUL3</accession>
    <name>A0A2G8RUL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_12916</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUL3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUL3"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="4">
        <location>
            <begin position="8"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="177" mass="19721" checksum="995D786F2A3CAE85" modified="2018-01-31" version="1">MPPPADFLRPLVISGPSGVGKSTLLKRLFADYPDKFGFSVSHTTRSPRAGEVDGKDYHFVSQEKFKDLISQAAFIEHAQFSGNFYGTSFMTVGDIQKSGRRCLLDIEAQGVRQVKATDLNPVYLFRLATALKEIEYAKEGTHDLVIVNDDLNRAYEKFRRVALGEPIVPDSLPPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUU1</accession>
    <name>A0A2G8RUU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUU1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="87" mass="9378" checksum="BEEB50AB048746D3" modified="2018-01-31" version="1">MRVLRRPPEFDLRVFDVGYKGKFEAVLPIPRAPAFRWFPSPDKLIEGAVTLSAVAVASPSSVHNELETNNITNIVASTVAVAAAASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV65</accession>
    <name>A0A2G8RV65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV65"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV65"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF1">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="150"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="365" mass="40374" checksum="7141846AE28A639D" modified="2018-01-31" version="1">MYGDIEDLVLSGRLFAPPSRSSSPVRPLSPSDASEAWHPEADDFAYDSDAERRAEIEAHVASQQPGESQSIGMGPGRTGVKGVIRDRREAEAAARARRAEEVRELNRAMEKASLGGRTWAEEERERRAAEARAEGVGEKGENGEKGKKGARGGRYGHLREVGVRSYVQAVEEDRSVWVVVHIYDPSLDRCATVDDALTRLARTYPHTKFLRARAGAIGFASGQGSKPNLVNASSSLSYSRVPSLGTVPRRSRIQEKDEDEFFGDEEDEKASDGDEDEDDDEQWEDDAVDTDVLPTILVYRGGDLVHSWVRVDWEAKQGIEELLKRHDILTSPRHFGGTSGNINLSDDEFSDDGEELVFGNSDDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXD3</accession>
    <name>A0A2G8RXD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_11931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXD3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXD3"/>
    <dbReference type="OrthoDB" id="2757090at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="357" mass="39822" checksum="32EBA917DFE38C86" modified="2018-01-31" version="1">MLNRPWNIYAEELFPLGYGHPLWYAEANFTTGRQVLVGDIGILHESQFRPLFNTLKPGDDPLNQGNVPDSFQPLALPSGITRTDLLTQPILVSEGITLQGETNDPTAGHRWTFRSHADAGAVLVQDPPGVADALDVRTARPAIINYMRENLDAWRSPAYVQQSEIGDRDILFVCGTVKTTRWGTAAVRDRDFRGREGRVSGDLAWSNNRAFYVEHVLWDYTMTGPLYRAGGPRPEGASQCLFMHYFKMKRFGAASGDDLVESRGRPIRMGGYIVERCPSTPPPEMDYDPVNCLLDYILKNSEAPFAAASDMDVTDLFRGQPFPKLDQLPRAIKRASPRIEIDEHDVGTISIAHAPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXP9</accession>
    <name>A0A2G8RXP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXP9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXP9"/>
    <dbReference type="OrthoDB" id="2749026at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="673"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="762" mass="85666" checksum="E918EC084ED922BB" modified="2018-01-31" version="1">MWLLSTDRAELHYFARNFDAEGGYAVLSHTWDKDGEQSFQEVRAIAKRCLANGTNPRDDPELSPKIRECCILAEKHGYHWVWIDSCCIDKMSSSELSEAINSMYKWYKSSEVCYAYLKDVPSDDVVKARDSAFRKSRWHSRGWTLQELIAPDSVVFLSVDWRELGSRAELSLLLQVITGLPAKLMLGVTRPAEYSACIRMSWASKRQTTRIEDEAYCLMGLFGVNMPTNYGEGKRAFLRLQYEIMQHKECDMSLFAFGEPILPKEIIRDGIVFEGRNEQIDRDNPWQYLLGDSPRQFRISFRYIPDLGSDALQKYPPPQPSVTTAIGPFDRVELPHATVTSYGIQFRLPVAVVDDVTLAIILCQAGSRHFGLFLTRDDRAKDPQRPRYFVGRGYTRATTRPAIYLARMCDLGGDLYKLTFNGKPVQASWSTIYLVPTASDLDCESATSPNLLINCHPHSLFQLPRWLVDRLIGLRFEVDEARYSATLQIIRIVHRSEGRIYLCIGKCTKHPGGPEGSKGPLWAKVFVSTLVSPKEFTHDCSKDHLDSESWAMRWRDFGDEDRMVRLSFTESRRKLPETGVVIHLELLGRKFKKILQGSGISFPSVADMERDPPCTFPDALVVSRSSSDSHGIGRSLAEMLESSSDALGNISDGPIGALLQQLMDGQDKKEDSPQTTPQANPSGAASPQPRTPSLGIESVEEGPLRHTPDGRTIKLLLQRILDGLHEGSSDDAQRRHSKPHPQPFPGRHAVPVGSLFTADRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY42</accession>
    <name>A0A2G8RY42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_12197</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY42"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY42"/>
    <dbReference type="OrthoDB" id="196786at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL26439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1072" mass="117207" checksum="910E0E4CCFFAA9E9" modified="2018-01-31" version="1">MSSASIEKQVSDIEVSHDLTQECQTLSHHVDSRKVFWKLDIRLVPLACLLYLLSFLDRTSIGNAKIAGLVGDLHLTGLRYNLCAAILLVPYALLEVPSNLALKRVGPSKWIPFIMFCWGIIVVAEGFVKSFGGLMTARVFQGMAESGIFPGLTFYLCVWYPRTAHAQRISLLYSAVTLAGAFGGLLAFAIVKMHGVGGLQGWSWIFILEGLVTVLVAAFAWFYMSDYPDKATFLTEAEREWLVETIKRDSLGLSRQFKRKFVLQAFRDPHVWLLFGIHFCLIIPGYAFSLFLPTIITGLGFSASTAQLLSVPPNAAGCITTVVAGVLSDRVHARGPFILVGSLVALAGYATLFATANPWAGYAGTILAACGLFPSIACVLAWAGGNSGGEVKRAVAIAIVIGCGNLGPIVSSFIYRQQDSPRYLPGHGTGIGCLCVAAVLCTIAMLEFARLNRKKIAQCEREGITEDMAGEFVEMGDASPLYRMTGFPEFRVQDVGVKLSTSSDGMADQHTYDYIIVGGGTSGSVLASRLSEDPNTSVLLLEKGPLADSWSSRIPLIGGNPLSKDYLGVEWQSVPQRLADNRSISIMRGEALGGASRINGTPGDYNRWEALGNAGWGYKDLEPYFVKSESTQTHQESEFRGKDGLWMNRKVVNPFKTAPHIDEALQRMGFEHVQDLNDPKAPAACTGALDVIVDSSSRRQSTYWSFLPPELARARRERLKVCTRALVKRVQLDRLHGEVCATGVVFESTDCEQTPGQEFFAKARKEVIVCAGALVSPQILMLSGLGPKDHLHEIGIEVVQDMPAVGSHLQDHIGLPVEFTVPIEDSLHHLQSSPMKTLVEFVKYLFLGTGLLSSAFQFTSTFIPTRLLRDDLTIARDDPRNLDATLPENRPDIEFMHIPVDCVRVQTPGKGTFSFLVALIRPKSEGTVRLVSSDARTPPAVDLGYFDVPEDYVPLRAGVRLALRIAEDVRRQGYPFADLVVPEVDNNEGIDSFIRKNVMSCFHYTSTCRMGPGIDGSWSSVVDAELKVHGVKRLRVCDASVFPEIIGSHTMAPAVMVAEKCAEMVKAARIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY77</accession>
    <name>A0A2G8RY77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY77"/>
    <dbReference type="STRING" id="1077348.A0A2G8RY77"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39915" checksum="98FBC8D1AC30DEDD" modified="2018-01-31" version="1">MPAPAAHDNPPLKRPRTSESEPLPLPSTSGTTQDTGPGLIVRHSEELWFGDGNVILAARHTGFRVFRSLLATQSTVFAEIFASSSSGSDPEIFEGCPVVRVSDTPEDIAHFLRVLLPTSQRILFSRKFSFSFHQISAIIRLAHKYNVLDICNQAIASLQDHFTTDFAAWDRGANEEVIKVRFQQSIGVVNLARLVDRPALLPTAFYKCALLGCDVLAGYRREDKSIEHLSPEDLKRCINGRNKLVEEAFAILLEVFVSRPCDECTTDVVCRTALQRLLEVALVSCKQASASVLQGWDDLIQECAQEWHLCAACVKTVLEREYQARKRVWDALPVIFDVKVDGWPSAPRNKDGDAPASANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYK2</accession>
    <name>A0A2G8RYK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYK2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYK2"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="80"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="471" mass="52323" checksum="B3049690F6EE9465" modified="2018-01-31" version="1">MASLRLSSLAARGVVASAVSRPSPVAVRGFSTSLTRRQNDPATSADSKKPTFAIASRLKDGRALALDVWSVFNAANLPQDCINLGQGYMNFPPPVWARDAAEEALRSVEGNHYAPAKGRLRLRKAIKQFYGTQFGKELDPETEIVVTSGANEGQYAAFTAFIEPGDEVIIFEPFFDQYLPSIAFHGGKCVYVPLHPSSEPAPNVKIGKQSWTIDFDELRRAVTPKTKMIVLNTPHNPVGKVFTRAELEGIAKIAEEHNLIVMSDEVYESLVFDGLEHVRIATLPGMWERTITVGSAGKLFAATGWRVGWLVGPPSLIGPTTAATTRIVFCSNTPMQEAAAAGLEQARERGFFEQQLAEYEERRGVLIDAFEKLELEYAWPEGSYFILLDISKVRWPKNYTFPATIEGRGRDFKASWFIANEIGVSSIPVSEFYCEEHVAIGENYARFAFCKDLDTLRRAGERLQRLREYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYY4</accession>
    <name>A0A2G8RYY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000040">
        <property type="protein sequence ID" value="PIL26694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYY4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="178" mass="18576" checksum="7425C0E8008D4684" modified="2018-01-31" version="1">MLDIIVGEESPDGKVLSDSDDSSMGELPMVIIGEVEVGSEDESSQELALPVVGEEDADGDPSWAVELPIMGEEEAASLISSPLSSPTMSCTEKTVQPAPIVPDFVHGMNTLRVEDDEDSSASDLELPVVGEADDAFAAAASSSEGSKDSDPEDAGIPPDAPNDGFDGRHPACSFIWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ14</accession>
    <name>A0A2G8RZ14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000039">
        <property type="protein sequence ID" value="PIL26724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ14"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ14"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="246" mass="27193" checksum="D205379A12731BBB" modified="2018-01-31" version="1">MAAAKLPLLPLTIPILKFSESRFHDLIAPRGQVAPLTHRQPVSTRACLPAPIPTMAEELVLHPDTLETVLTVPLGPHSSHGPHERRQRCDVNKARHRPVSNPEGRPMRARKVGTLTSCFVLDRPARVSPGQGKVLKPLSELRLPVMVNDHLGGYTVPGEDDREVDDDGVGREDAGGVLELDDVLGWWPGFKFSQLEMKVVLAVLLTKFKFELTEKPIYWNLAPVTYPTVVADGSHPELPLKVTMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZQ9</accession>
    <name>A0A2G8RZQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZQ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZQ9"/>
    <dbReference type="OrthoDB" id="2756145at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="82" mass="9080" checksum="20CC85A502AA9B49" modified="2018-01-31" version="1">MVSSLLDFDRYVVITEDDRPPKPKTARPLRGVKGRGSVVLFNQASMFQLAELGYTITEGKGKGLPTDSDNDAYRSQMPAFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0I5</accession>
    <name>A0A2G8S0I5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0I5"/>
    <dbReference type="OrthoDB" id="2756194at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="770" mass="85905" checksum="F1C8C91DCE65E66B" modified="2018-01-31" version="1">MSSNSPEGRRGSQHVDPDNSQPAAEWSPGTSQERLTEQNAGSRPITKLQSHAFHASPHPALRPSIPLVANRNGVAPQVCKAWEGKVASRGGLDGFVFTSPNMDFVPDYPVHKEVINTNEDGRWGLHEYSRWPQPYVDSMMHLACIPRQPALPHLPRVLFKSLHPSSDWTERIELMVKGLGFVYQETRSELAKAANLAIQRFHATKNVRENVQRYGDFLVMLLRQVVDRMTYVASHSRTAIAVAAHVQRLCLELAGLKTYVELVVPRLESTVDFSPTLLPVLGGFVRDLTDAQTWCRLGLPVWLIQPLTQELVIWRVVDPVGLPSGMSDSPCSPPILHKTGSFVFAPNVTGNWLTSMLMSVSKHLGGSHLECMNLASVPKIPHGLPDNKRARIEEGSTQLAMRAAFPIDGEPSSSKVSRRQRRKQAAAERAALNGTSTTDPSASTLSGTRHPSRTFLPSPFCDPAHVWAAALRSASPLPQTCNSALYFYPPPFLLDTVCAKAPVPEGNAHPERARVDEKVARYLHNLVRIREFCRARLFDKTLSSKPLSIGEWRAALWGDYNPQTSVRAGGTTSDARRAKRRLEERNEVGALLHQVGHMDRYSTDIVVSLEGITVAADTVATNPAVRATLLWESHELNFRAELMALDHLLVNTSDWPERFKWEREMLVSGAWGEPSSGLSVLPSLEPDLRQYCWCAPPDEGWEDCQRFLRAFAQVLSRWHGCPEVVLQVRKMDGKMTADQFSEVQRSAVEFYVRSFTRSFLRLPIPPIPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S219</accession>
    <name>A0A2G8S219_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_10974</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S219"/>
    <dbReference type="STRING" id="1077348.A0A2G8S219"/>
    <dbReference type="OrthoDB" id="2754979at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="171"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL27820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="756" mass="84564" checksum="C88F07C5FA48192C" modified="2018-01-31" version="1">MLQKDSDGNHVYGFLQVGSDESTFQGEQRLSYQRVLYPASTEALEVELKEQCLWIWRAMRNCLSLSGNVLKKGLGSYAHICHVLRFHVQDLQMGHHEFLPLCRTTEGQVKAMLDSVRLVINAHQERMPIGTNATDQLRVRAQRDHVAPSVQPGKETLFRSLWLLNIPVVVPNATDGMQCSWTPRDFVDMHGHVCVKMIKVVDPSPVEVSVTVREFFEKFSQEDSECPFAIKVKMYIATRDPEEQGSTPLHLDATSAVNVLVYSSAGDPQAPGAMWHIFRPEDSDPIRGYLHEKGLYGEDEDPIHARKTYLTLTMRLELAERNVHAFEIRQRLGDAIFIPAGCAHQVSNLHSCMKVACDFLCTEGIALSHAMTEEFRRASMPDVLQLQSMLWHSWVSLGAQRAHPTSCPLTRVQAKRKRSRETPAAQEDAARRKKHKTHRHDGVPMPLFHGYQCPHPACDRQDRTFTQVHGVFSHLFEHLSVDAFREHYAKAFAEGRARVSLLRLLRTSARLTVAQPVTSRMTCPEAWSVRLLVIWPYHNSKLPSPSTYGTPSTLSTVASSPSSTSFPVSNTPLIVRLADGTLHHLVPTDTLTDSSPPSPSSTPPIPIPPPHLRYRSPALSSDSDLDSPRPASTTAVDSDSDYDSDPNDLHATGTIAVSRVINPAHVFFLQTTINTPLFRGTERTAYVARSQYPIVPGHVIFRFPAARATTTTPAYPAYTLYGILALVEPTYFVFHVSLIPYVTNYITTLHITPSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S225</accession>
    <name>A0A2G8S225_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S225"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="86" mass="9309" checksum="9C63C7BCA4597082" modified="2018-01-31" version="1">MLDPNNLSSGRDSPDPSVSADATQVEELTAAQEEQSRTLLCKQTLFHSCARRGVNVGPQLLSLNGVKLGKIRRSNAQSVMMLLKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3M1</accession>
    <name>A0A2G8S3M1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3M1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3M1"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPX" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="105" mass="12060" checksum="0FD96B08E499453A" modified="2018-01-31" version="1">MRWPSGGMSTSPWLTTSSGSYEALKKHIYQLEKQKAGLQESYHDLEANERTSLMAAGHSRTDMGNTGAFFLLLLERELRKICAFYETKEQHFIDDFAPLQTDIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3M2</accession>
    <name>A0A2G8S3M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09486</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3M2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55347" checksum="D8A9C8B4D804C528" modified="2018-01-31" version="1">MAAGTRYWIPLEYAQNPFVCGVIGGPSLGQALRHMPTLRSISVLTRERAVHGLSWTTVKTILSLPQIQEVSITGLLLCPSKLPHDDYRLDSWAPLTSFHYEVFSNRIDGMKTRQNYPFPSEEEVLLLVLSRIHTSLEKLVLSTEPAPLLAMSQWTWPRLRELRLRGERRSLPPVPYMTLLSAMPNLRTLILEFTLVSEECTHAGPLWPPGSHMPFPWPDLTHLSVANPNPSDELYRYLPPSVRVLSLCCRPHKSEKAWISTLLIYTVHVYEYPVLTSAEMLGILENCHLPHLTRLEIEYEVREREGELDLLRRLGSMFPQLTWLQIHRYRAATPSGGPGDIPPLASQMQAGAGLASAGELDFIDDIAQALSHLPRLHTICAHLDLPQQPKIQDNYPFYYNRAKIDEYTKTLRDVTHCLARTIPSLETLYFWRPRRTGHIEWAPFEVVRADGAAKDDFEIRCPEDVRTYGGPQYPVIPMPDLYGVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4F7</accession>
    <name>A0A2G8S4F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4F7"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013930155" evidence="1">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="132" mass="13704" checksum="2BDD1C1892D5ECDC" modified="2018-01-31" version="1">MQFLTLVLASLLASASVYAADIVVETPAEIVQCAETDISWTGGVDSSRLPSSIKRLTTSIKDNGDIVGEADLVFDTTYAWGGYGCPAGSTVVVTVTDYDGDGASTDPVIVSNSCECTASPDPAYSGRFADHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4I5</accession>
    <name>A0A2G8S4I5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4I5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4I5"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="78" mass="8613" checksum="22208E19E8F1117D" modified="2018-01-31" version="1">MIIKVKTLTGKEIELDIDPEDQVSRIKEKVEEQSGVPPPQQRLIYAGRQMADDKVVKEFNISAGAVLHLVLALRGGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6G0</accession>
    <name>A0A2G8S6G0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_09404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6G0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6G0"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="105"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="504" mass="55483" checksum="468D0C7FF89D8743" modified="2018-01-31" version="1">MAESSNFVDLAHHLSPETLVRKANPLKDLIRVALENPHLVTLANGNPHSSLSPFRRVDFEVASLTATDDPVSSWRALGPSAPTQSLAVGDPSDAESTQLLRASMQYGHGAGLEQVLRVVADLNAFYHTAPAHVVTMTLGNADAITKVFRLLGAPGDYFLADEFTFGPMPLAADAHGVRWVPVRIDAGGIIPKELERILEEWDPERGRRPHVLYTTPCGQNPTGSTLSLERRRRIYELAQRFDFIIVEDDPYYFLQYDLPNTPPADPAKPFPTSFLSLDVDGRVIRIDSFSKVLAPGLRLGYITTAPLFRPHLVNLIDFSTQNPSGLPQVLLTQLLGPGGWTLAGFDRWVRSLRHDYQRRRDHFLALFETHVASTGWAVADVPEAGMFFWVRVFVERHPRFHASAPCTDANGSGGQARVVARSNAKEFMAELFEACVAAGLLVCPATIFVLPTDGTFDSESIDDRSNFLRLTFAGSEETMNAGIPILGKVLNEFFGNPGKPDQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6M1</accession>
    <name>A0A2G8S6M1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6M1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6M1"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="578" mass="64904" checksum="752C1A59066E1167" modified="2018-01-31" version="1">MAPPVLWPVDLIAPEGICYGWKRPLICIAGVLPIHDRSEAQRVLTSTLSRTEWAAVRHVFSSDPAILGYCRPDDGRRTPELSFDDDILPSGTAGIQLILYRRHKRQSMRFYAFNFNELDIQPSQEATGVSTYSTYLTHKDFLKADFTRVGNPDTRKGTALDGEVLSQVNLAQLLASIIDKEKSGSRALPRSTPSTPDLHKGGNTSHPGPGRAMAVVAAISKAYSISRTFSTTAEQFDIRYEQGVYVYGEVPYVYRDKARTVQSISKFHNCVWLAFNDVIIGVTFGSFLSENKDYLARWLHYCLQVYLVDGMRDALLWLNHWPAGLKLNTELSEFYCHSLVGVVSAWGWLLQYAAPHFPALIWLVGAGGCCGMTMVVSLLSDVLSVLTAHLYVCYWISATVFRHQLALAGALWNLFRGKRYNVLRNRIDPWDYDLDQLLLGTILFTLLAFLYPTVLTYYALFATARLFVMILHGMFDTSTALLNHFPLFALLLRVKDPLRLPGGVCIQRSRTGTLLLSSLPAPLSSIFRHYAHLAGRLTTHYHPLRMLRQLASGRLLNPIPRAAIRYSMIPAEGVLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7A1</accession>
    <name>A0A2G8S7A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7A1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7A1"/>
    <dbReference type="OrthoDB" id="3353673at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="332"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="404" mass="45509" checksum="3D8AF885EA2A3312" modified="2018-01-31" version="1">MAKTPSSNRSITAFAEFDILIRSLLPPSVSPPLVNQPSVLVSTVDVGHPLPSAPHPIFPKSSTLMASDAIVLDGPNSRPSTSGQHMVMPVNGVKRSFTHLLDEGKYEDPRHVDPLPFLVSLPSNDNDAWYYPSYGFEPNDEDLPQPAFRGNWGVKTYNQAKWVRKGKMTAWGPWMEDWEAEDRARKRIRQLLPSEEEPDQPLTLPHLRSPSPPLMAPYPHPNTQHLSYTSFVLDKATTHSFRSRVFDELEDSTNMLIEGETSLRRALGRLWQVMSENPDEVGVGTSLVPKREDEAEDNDADSRLARAPDLTPVVHKLFLSPNQESIFENTQFSRAEMQLDKLEKSLSTLRELQDDGREYVERLEEIREGLGDARTQRDGVWELVRRKAIQELQEVASSAAIGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7A3</accession>
    <name>A0A2G8S7A3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_08293</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7A3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7A3"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL29656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="270" mass="30939" checksum="279ECC4971046A30" modified="2018-01-31" version="1">MSSKGVKRASPGAETEKNPFGDVELTDEDAVKLQGIQKDIARVELALERRAQEKMVPVYEKRRAVVKAINKFWPVALMNHEMIGVHAQHNADQAALSYLEDVWLVRDSTESRCFTLEFHFKENPYFSNTVLKKEYKYVSPPVETEDKPDADGITETMLEFSWERDVQPQATKIEWKDDAKNLTRLHPRVTHDEDEEPSEGGSFFNFFEIAEDPFDVGVAIANDVFPEAIEYFLGHAGGEELDSDEEEDSDEDEEEEIDLEKPRPKKQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7C5</accession>
    <name>A0A2G8S7C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08117</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7C5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7C5"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="54064" checksum="A96DD3ADE56543AD" modified="2018-01-31" version="1">MAQEHTDTQGLNTFPDELWDAAQLEDGFRGVGPAPEHQSGLGHYYDAGALAAYSVAPEFYVPVPDASGEVAFNHYDADGAHPSSAFGFLHYLPPAAISKKYYALQDPNVYPTDGPSTSSYASPPAAFDAEPSPTTTDAYYGGTQAMTSSPTPKVEPSEEHPPPSASFTPTPGPPSPLTTESSYDVLATPTPTPTPLASPAYYQDFRFQPAQGWHPVPSGPLECACPVLPKQRRNRDDPGGDAGQLAQVCANSPCEFEDQTGTGTPYYRDVAPGAAHGSQYAYHGPGAMSAQEQPAPVVVPSQWKVGAALDRLRFPQYGGDWDALMTTLYGEGYQAYMPRSNSPLNAEDMAQLEQLSLGFGLGLGLSSSVSASAQPTTPMTPITPATPGSAVPRNDDDDDDTKLVVYSPVTGRRIPVTAGPNGPVLQLSAVPPSARRPYKRGAVAACAFCRRRKIACGGPKEGDEAGRCGQCIQRQQRCEFPGSSYQHAQPVPLSAPPYGYAHAAYGVGGAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7I3</accession>
    <name>A0A2G8S7I3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7I3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7I3"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="238"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="534" mass="60449" checksum="69992FD08A781E0D" modified="2018-01-31" version="1">MAARPPPARPHIGLNPTNKFSSYSINDWGEDDAWDSASDSESTSKPDWKRSANARASSSTTAPKPVPRPALNTSSSTLAFSYTHVATPSSYPPKGEQPSKNGWTIVRKSTDRGSVESRESNHLAHSTGYDELDGDMVLGEMESEVDDRSGMLASNSKPRYDRGVLRDDVLEIVDDPLRLIDGQPGRSTSAFHTPSSPGDSEKLTREQSIRTNRRSKFVECITREDVDIAQLRKLAWNGVPDELRPLVWPLLLGYMPLPKPTRISTLARKRREYASLVETTFSRGRDGLDQQIWHQIEIDVPRTRPGVQLWMQASTQRSLERILYVWAIRHPASGYVQGINDLATPFFQVFLSSYIDSDPEEFDTGILPDNVRTAVEADTFWCLSRLLDGIQDNYIAGQPGIQRSVKRMAELVARIDSRLAAHLEAENVEFMQFAFRWMNCLLMREISVQNTIRMWDTYLAEGTDAFSQFHLYVCSAFLVQWSKKLQAMDFQGIIMFLQSLPTHGWTDHEIEMLLSEAFVHYSTWHNAQSHFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7T8</accession>
    <name>A0A2G8S7T8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TMEM205-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08046</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7T8"/>
    <dbReference type="OrthoDB" id="1641132at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053009">
        <property type="entry name" value="Xanthocillin_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PLANTS LEA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23241:SF102">
        <property type="entry name" value="LD23009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="TMEM205-like" evidence="7">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL29839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="160" mass="17227" checksum="F4B6992596CBFE81" modified="2018-01-31" version="1">MSQTILPASHLLSYGMLLGTAVYQTFVMTKVAYLALPTSAFTMLQKRVFPVYFRMQSLLIVATALTYPPTSVLALAQVPLDAGLLAFAGATALANLAKYGPATTAAMIARTHQETRDGKKHDDPSGVSEEMRLKKRAFSRNHAMSIHLNLLSGGVKRGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7X5</accession>
    <name>A0A2G8S7X5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7X5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7X5"/>
    <dbReference type="OrthoDB" id="148331at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000003">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000005">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="298" mass="34309" checksum="D0F666720CDEBB51" modified="2018-01-31" version="1">MILLESHNYIIYTTLADKALKPSSLDVQFVDFDGVRFHLSTPDRKTVLVLSMNIRCWDELVRYGVHDILQREYGPLLKSAPENDYNVSLEIDLEQLPPEGEQRDAFFKGLALLKRNALAAPFELGFQAQKQLEATGSGQGDLTALHYRDEEVIYVQASSDRVTVIFSTMFREETDRVFGKLFLQEFVDARRLPTIQSAPQVLYTTRDPPLEIRHLPGLSDSEDVGYVTFVLFPRHFANAIVASTTITHIQLFRDYLHYHIKCSKAYMHSRMRHRVSEFQKVLNRAKTEQAIVERKTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S929</accession>
    <name>A0A2G8S929_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S929"/>
    <dbReference type="STRING" id="1077348.A0A2G8S929"/>
    <dbReference type="OrthoDB" id="3199698at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="114539" checksum="A2A69E4DF579C2B2" modified="2018-01-31" version="1">MACRPRRKQHNPHQLQCPHCKDKEKWCKNLSGLTQHINAVHLDLFHSKTVDPPPSPPSPSSPPSPINSPPPLLNDMENNSGDHPEPQDSERQEEEEEEEDIDLDSPGPPPRTNAISGDWAPFSNRIEFELAEFLFKREQMPQSNISFLMDLWAADVMQHGGRPPFADHADMYRTIDEIALGDAPWLCLRIRYTGPRPATNIPQWMTEVYEIWYCDPRKIARSMLANPEFKGHFDITPYREFTRSGERRYGNVMSGNWAWRIADAIAREVAGSEGGMVVPFVFGSDKTTVSVATGQNDFYPLYMSLATFDNSVHRAHRDSVIPIAFLAIPKAERKHADTTAFRRFKRQLFHSSLGAILQLLLPGMHVPEVVRCPDGHYRCVVWALGPYIADYPEQVLVANIVQGWCPACYKVPANLDASEPGQKRSRRYSEQLCTMFEPKVLWDDWGIVSDVIPFTTGFPRADIHELLSGDLLHQLIKGTFKDHLVSWVGEYLTMTHGEARGKELLDEIDRWLAATPPFPGLWHFKQGRDFKQWTGDDSKGLMKIYLPALSGIVPSDVVRAIAAYLEFCYLAQRPYLTDSTLVKMEEARKRFHTYREIFRTSGIRLDGFSLPRQHSLDHYIQHIQNFGAPNGLCSSITESKHIKAVKEPWRRSNRYEALGQMLLTNQRLEKILHARADFSARGMLSGTCLSEAIAALALAQHPDHNNPPEPPALINSDEDLFEDDPYVDPLDDDDEDGDGVAPSLPSNDPREAGSPEDNHGDADQVNQDLEDGAVGGPRVSGFVVLARKPQPRYPKTVDVLGLHIGTPSLPMLMSRFLFQQLYPDTDIPDDLNALPICPSRVHVYHSAAATFYAPSDPSGVGGMHREHIRATPSWRKGPARYDCVLVGADPTQRGFRSLMVARIRLFFSFHYIDSQLVMDEARDFSCALVEWFSAVGEEPDEDTGLWVIEPDLDVNGQRVLDIIHINTIFRSAHLIPIHGTHHIPPYMRASDALDSFNAYFVNKYADHHAHEEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9F7</accession>
    <name>A0A2G8S9F7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9F7"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="84" mass="9497" checksum="35A0DA7DDF10FECF" modified="2018-01-31" version="1">MTDGSNSTAIIAAWNAMVVGNYTEMATMVVVLYEYVITFGVEVDLFWGKEITGASIVFFLNRYFVLVYHLVQLPSWFLLFSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9W8</accession>
    <name>A0A2G8S9W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9W8"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="37106" checksum="79367CEC8AD882B7" modified="2018-01-31" version="1">MAAEGIPLDRAYLVAIWLETLFYGINLCLFASYLYITRFRQVPREVSPLIFWVACLMFAFSTVHVSLGFARLIWGFIDYRDEPGGPAAFFSDVSQPPNVAKVTIHTINSILGDSIVVWRCYHVWTGEWRVCVLPVLLIIGSAICGFGQAYIFATAKTTHSAFATTLARWNGSLFSLSLVTNVVVTGLIAVRLWYITRETGGVKKYRFFRAFLLIIESAMIYSTALLIEIILYFSGNNAFYIVYDPIAQLTGIVPTTIIIVAALGLTYRNDSTAHPTTNETTIQFSHIHTRASRPWASTATDTEIADDVGLPKGFKAKAADVEACSSAVPWQKNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA22</accession>
    <name>A0A2G8SA22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA22"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA22"/>
    <dbReference type="OrthoDB" id="2758403at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="53555" checksum="1867C99C926091F7" modified="2018-01-31" version="1">MSRKRRATSLLQETIETREDGSLGSHQGNLTAKPALQSCPTLPLELEHMIIGHLHGNLVALKAASLVCKDWTKAARRHLFHTVELAGVNQLLRFSADVPLIPDIRESVQVLEIRGEGDQLMAAPQPLPTYVNFVVDTVASMPRLLELHFVSAPMVFKPFAINPPRRSSLRFLAFTMRNCSPEDFQCMLHIVGLFSDISSLIFSMIDPMNVDGQAMPSPEKLLQAGVLPSYGPVKLRCLEIMGINHHWLPLLLCTLRHVGALRDRTLAMHLWPNMVRNSDMAVEAASATRTSLEGYGAFFGGLGPALRLLDVDLLYPIAAAREQLNGNLFTILGLSACTNLQWLSLYLDVPNDLDDAQVILASTLRAYTEILATTHFPALNFVALHLIADGATDEDELFYDLDWSLLTSALLGLPALFRFVIYMRCNRPRAPMGGRYLQDLMPLHRAGKFILIHAKEDASGQQAIPVLHPESRDRGILLAEGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAE6</accession>
    <name>A0A2G8SAE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAE6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAE6"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46891" checksum="5FA15F46FCB7D68A" modified="2018-01-31" version="1">MLVRHRFTPPSDRMGPATPSTTSPLTAVERSLRDSLLVSEFRDVYLYAFSRRTILPDGTLRINHPLPVVTISSILKNTDSFSELLRDPGAVQQQAPLSEYDYDSDSDLDEFEVLGIEDPDVSPTGPGPVSAEESSPEGNSKDRTEDPANDQAAAKGSTVVATQRYLQVPIPNIAYKTLRACVFYLYTGKIDFLPLTSSGAAGKWRLLRPSNDLAPPCSPKSMYRLADLYGLTELRDLAYNEVVSQLRPENILEEAFSSFFVRYDRLREHAISFLCRNYYTSAVQESFPDIIQRIALGEMPHASGVLRSLLGLPAVISLQAWGRVPHSRAVKRAHLLGKKPMPPPLSADGLKPQSTLKLEEPCQPGIVSDVSLQVGVAPEPVPPTSESTPPTAPGPSSSIASSTPASDSINGETLQATLEAEPAETAAMCGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAJ4</accession>
    <name>A0A2G8SAJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06939</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAJ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAJ4"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="110" mass="12134" checksum="DD8DEB3041397A67" modified="2018-01-31" version="1">MSGKSTYLRQIALLTVMAMCGCFIPAEYGSFRIYDHLLTRLSNDDDLEKNLSTFANEMASTAMILGLATENSLVLIDEMGRGTSVREGVAMSHAIAEELIRLKSFVFFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAR1</accession>
    <name>A0A2G8SAR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylosidase/arabinosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAR1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAR1"/>
    <dbReference type="OrthoDB" id="2589715at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11576">
        <property type="entry name" value="GH99_GH71_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="104645" checksum="624EB0884D06D60F" modified="2018-01-31" version="1">MASLTKGRTLKRADPSTIHDKFLVGYQGWFTCPGDGNPVGPGHHGWLHWFNYPIPDGGRPNTDLWPDTSEYTPSELFAAPGLRYADGQQAFVFSSRHPRTVQRHFNWMALHGVDGAFLQRFLGQCDVEQGNDGIRRQRDEVGDLVREAAEREGRVFAIMYDISGVAPDRIKRVLEHDWIHLIRRRGVLDSPAYLREQGRPVVALWGFGMSDAHHSPATVRAVTRFIRDNTPGGAYIMAGVPAHWRTSVMDADPNPEFVRVYMEELDAISPWTVGRYSDEDGADRFEEEKIKGDVEFIKAHNERWEMHKTTMRKIDYIPVIHPGGSGYNLSEGRWKWNDAPRNGGRYLWRQVYNVRRHNVRTIYGAMWDEYDEGTAFMPVVSHKRQVPVHEQYRFMALDEDSFDLPPDWYMRICGFAAEGLRGERLVLDTFPSKELQDYWSSRPHYEDKADSSPVVEGSGSGSGSAEKEEGQTWEEWSKMQSKENGDEPPPPPYSLEADEPQSQAASSAGPPVVPLGRRPSVQAQAPPSTPVSTRPAAPTVNSGSRPEKFPIAPQNPSATRHPSSPQLSPHLVPVDEFSRLAVSSSHPSSPKPDQAQFAQYHHVHSHPSSPHLSPRPISPAHSQHSHQSHHSHTSLHSAPYRPTDPGLAPHIFPTPSDPSPPSDPPGQWAQATWPPREWNSPQGPTAIPVIGQLFQDSSHTPPQHGLGYSPSYHPPPNTSSPPPPPSLRPRPSLSHHSRPTSPPTQGHRPSSPHDYVGGFAFPEAHIPGGSDNSYYDRPSSHSSYASSPYNGAPQFPGETSYAPPAGPPPNVPPLPTSHAPYGNASIPGSSYSPAPAEHHHHHHSQPPQHPHQQQQPHSDYGSSSQSYAPPPGPPPSHPAHASSSYGQPAGPYYGVQPSGGYGYGQPASGQSAGGPLGSALNLVGNVAGPGAKHSLQNLANTGSKLFNKYTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB02</accession>
    <name>A0A2G8SB02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_07081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB02"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB02"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL30912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36058" checksum="2F5912B026C0587E" modified="2018-01-31" version="1">MPVMTSSSPTKPTDPAPLAGDENKPQPHFLTEGYSSIPKEDLDFVREQTGIKDEDVLRQHIFDVQAEALSVHPYKYIKVFAFVKMKLSHDMPGYSALLKLGREREGAILLDIGCCRAQIACNHIKAVSDGFPVENCVATDIHPEFWDFGHRLFKSTQETFPARFFAGDVFNPEHLETVPPFTSPPTTPRPHLPTLNCLNPLRGHVSAIHISAVFHLFGEEQQVRLAHSIAGLLSPEPGSIIFGMQSGRAEKGFRVEAGRPTSHGGQMFCFSPETWREMWENVFPKGTIRVDANLKEVERPDLKPVSEDARFWLLTWCVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SB44</accession>
    <name>A0A2G8SB44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL30985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SB44"/>
    <dbReference type="STRING" id="1077348.A0A2G8SB44"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="197" mass="21925" checksum="96617490042F2BA7" modified="2018-01-31" version="1">MQIGEMVLHIFRLPPLPGISPEQLPQSLEECHRGLTHTRWHKSCYMQGTLTQLGGDCNVLRRRHLRIIGSSLIAYNDVTRRAIASIDLRKATAVDCGNRETIQSPASGGTTHSYDDDEGFSAGQHGFLLKFDTDHITFIADSEQEKDDWVNILKALIGRIPPNPLWAELLFQRQEQLKHAVQTHVAAGPSSTPPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBL0</accession>
    <name>A0A2G8SBL0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBL0"/>
    <dbReference type="OrthoDB" id="2758237at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57107" checksum="FFCF40CB0351178E" modified="2018-01-31" version="1">MASPQSAGSHSEVLRTRPVPPADIIAQVCEQIFAAPLHQYDLSLTRGRNGQWSNEISFRLSLPLVSKTWWKPATRGLYKHIVLRRLQQIPYLARTLSSKDSGIDFGALVRKITLFRCILVLPDWNISCRGLQAIFDRCVALEELAFHREPYHRDTLTESEDEYWPLVGSGHNPLWILPKIIFPALQARAPLALHKLDLLSFDCRDAQNMHVALHNLILASPHLASLALQNYRAPTKKLPSLVFLEELYLDFRGHAPKPSSRAIWMWNLPRLRSLTVVATELPTLALERLGRTLTYLHLSSDTPCTGAGFAQLCPALVHLVFYPPTHTAEAICALFDSSEPLLNLRHLDVWIKGVADTQAWTPSTATSILEHLRTRVAPALESARGLLAVTPLPRDLAVICHPSMLAHAGRGADGTRFACVRDVWMAQTALCVQPLGDWWLDEGMWLGSELPDPGAISQGHRSNRGEESESEGWTSESDRPLLMLCAEEDFSFTPENRRKAIDVLVKQKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBY6</accession>
    <name>A0A2G8SBY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T cell CD4 receptor C-terminal region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_05968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBY6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBY6"/>
    <dbReference type="OrthoDB" id="2758521at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021963">
        <property type="entry name" value="Tcell_CD4_Cterm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12104">
        <property type="entry name" value="Tcell_CD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013668104" description="T cell CD4 receptor C-terminal region domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="T cell CD4 receptor C-terminal region" evidence="8">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="359"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="445" mass="48023" checksum="C6E7365E2CF212B2" modified="2018-01-31" version="1">MVGRPLILSSFLFLSHLATATRTNRTIDDEKGDSVSGLLPEFSPPGAWHQGSTCGTACLVHLDPSQTLDGTWHDATYEPNDPEPRSITMRFNGTAVYVYNVLANTVAYADTGTNITFALDGSPVGHYRHIPRNTTLFDYNVPVYSNGTLQNTEHQLVIQAAGAMQSPSLILFDYVVYTFDDTPTATATTKNAKQAASKTPVATTQSSPSTAAIVGAVVGGVVALLILVGIFVFICIRRRRRRQSVHIQVIEEKRRRRRALPRLSILASELGPPSAATNEATVHSARSLMGTPAGDVESQHHDIGISQRSPLPLLAPISARSPKVLHEGQGSARSHAGSTALESPRGVYLFGGKSDVDTAVEASDRPPISLPPALPENSRPRPRRSPNRETVALRSEVATLRKEVEHLREKKKTKTIANNTSEDEEDNVDAPPPEYDGPGDSGGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC34</accession>
    <name>A0A2G8SC34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_06001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC34"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC34"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="672"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="927"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="768"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="830"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="862"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL31303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114956" checksum="1FFFFC817790624F" modified="2018-01-31" version="1">MAKGKSFGKPPSSGRPSRKAANALGYAKRQSLKSKTLGPGLSDVYEYQQEKVRRAKVKPLLEKDESMRVGGAESGSEDEEGASGNRRSVRPRLVGENDDDMGIAEDEDEEIDSDEAFEESDEERFAGFSFSQKGKTKSKPKRKTTGKARAVHFADVDLNEDSDEEAEAPAGDHSASEEDDEEEEEEEGDPSEFIDVLDVLDGRGEPDSGDDMGEVERRNQDSAGASRRQAKDEEDEEEDADEGMEGSDEDSDEESDEEEERNMVSASEDEGGEEGDNALQDLENFVSGLDAGQKRKAPDEDDAQGGDGSKPARKRRLLPERTEAGAENEFAAALGGGKLNLDDLLAPLEGQSSNLQSLKKSAKVLASTGGKIKTLSAPLPQRTAERLDREAAYEQTKEEVDKWKATMKRIQEAEHLSFPLQAEPKSRTSNLELAAKFKPTNELESAVDKLLKSAKMREDEISQTETLKMNHLSVEEVAARRAELAKMRDLMFRAEAKAKRIAKIKSKTYRRIKKKERARLAEKLGEGSDDDLDDEEARLKREVERARERATLRHKNTGKWAKAMRERGELDEDQRRDINEMLDRGEKLRRKIQGQGESDEGSEDEESDEEDGEEGMTRIRAKAFDELAALDADEREAPAGGKGKSIFEMKFMKDAMAREQRKANEMVDDFIKEMGGRDGDEEEDVQQEAERPQVTVQRIGGRVIYRPGAVQLPDMRPTGSLASDTSSVTLKSSDLLHESQTEQSASPPGSPVSQRPVPPPATEVNPWLVQSSSSGKAQTKHEVAVSKESAAAEKSKNKLRKRQQKRLEEKAKVQEDAAVDISMSTVMTLSGPSKAGESSKASSAKSIPATNGKAKPSAMDNQDSDSDVNSELEEQERAAARRGKGKGKANGVKAFEQRDLVALAFAGDNVVQDFADAKRREIAQDAPKEVDTTLPGWGSWGGTGTKKAAPKPHLIKKVAGIDPKSRADYNKAHVIISEKRDKKAAKYLVKDLPYPYTSKAQFERSMEVPLGTEWNTRLGFQRATLPKVVTKMGQLITPLEKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCE5</accession>
    <name>A0A2G8SCE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RuvB-like helicase</fullName>
            <ecNumber evidence="17">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">GSI_05956</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="17"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCE5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCE5"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 17" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="19">
        <location>
            <begin position="70"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PIL31258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="481" mass="52875" checksum="93C8A8E5FAF02BDB" modified="2018-01-31" version="1">MERIGASQLLSGVSYMMLSHKDLGAHSHIRGLGLDDRLEPRESSQGMVGQAKARKAAGMILKMVQEGRIAGRAMLFAGPPSTGKTAIALGMAQTLGPDVPFTMIAASEVFSLSMSKTEALTQAFRRSIGVRIKEETEIIEGEVVEIQIDRSLTGATKTGKLTIKTTDMETIYDLGNKMIDALSKEKVTAGDVIAIDKTSGKVTKLGRSFARSRDYDAMGADTKFVQCPEGEIQKRKEVVHTVSLHEIDVINSRTQGFLALFAGDTGEIKPELRNQINSKVAEWREEGKAEIIPGVLFIDEVHMLDIECFSFLNRALENELAPLVIMASNRGVARIRGTNLHSPHGLPPDLLDRVLIVSTQPYTPEDVKKIINIRCEEEDVSLTSEGLEILSRLASETTLRYVLNLISCAQMLAQKRKAEAVDSEDVKRAYEYFHDEKRSVEWISDQTNYLVSEEGVDFAVGGQPFGKPKTDGSSEVPMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCN6</accession>
    <name>A0A2G8SCN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06213</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCN6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCN6"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="351" mass="38380" checksum="5ABE7FB0EDE27453" modified="2018-01-31" version="1">MSQSPQGDIQERIAAARREAESLKEKIRAKRESSADTSLKAMAANEVDQLPRVVMRPRRALRGHLAKIYAMHWATDRRHLVSASQDGKLIVWDAYTTNKVHAIPLRSSWVMTCAYSPSGSYVACGGLDNICSIYNLHSKEGNNVKGARELSAHSGYLSCCRFLNDRQIVTSSGDMTCMLWDIEAGVRVVEFSDHTGDVMSLSLGPSQNVFVSGACDATAKLWDIRSGKATQTFTGHESDINAVSFFPNGDAFATGSDDASCRLFDIRADRELNAFTHDNILCGITSVAFSISGRILFGGYDDWTCNVWDTLKGERVGVLTGHENRVSCLGVSSDGMALCTGSWDSTLRVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEI4</accession>
    <name>A0A2G8SEI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEI4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEI4"/>
    <dbReference type="OrthoDB" id="2752950at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="174"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="320" mass="35553" checksum="27D4EA4D6B0B9168" modified="2018-01-31" version="1">MPFVPTAEQHLSTAVLLNLVTASFAAFLIGTYASIFLYGLGVHQAYRYLRSFRQDPRYITFLVIAVILLETFHFAQTIDIWLSYKEDDYAVGLLVAQTFFIRRVALITRRHRLLVTFVILCLVAEIGASSASYTMLKNVLSSSACWLHRLHFRFLPSFSLGTAAFLSAAAIGMAAIADTALTIVYAISIRRSRKGRPRPESESWIDVLQLYLVNTGVATGVFNLLAFLAACALPPSQTLVPLSIGSISTRLYANTLLAALNSRQQRGMEFVSDAERKFSLAEARVAAKLDLWNAPQLPEPVAPRKISIQVHMQNEGSRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEI9</accession>
    <name>A0A2G8SEI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEI9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEI9"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="92"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="249" mass="27786" checksum="FB39A494D9E13657" modified="2018-01-31" version="1">MSESPPQSATPTPSTSAQDPAPVEPAKPAFRYFRAPTSAQQPRVDVPDSFFDATTSDIRAQQASLTARSNALQNAPLRTAAMRDADDKKRRARWPQTTIRVRFPDCTVLEKTFPSSDKIKSVYAFVRGSLREDVKPIKFVLYQSPPKREYKVSDPAVRNLSLAELDFAPSSLLMLQFEDPTLNHQNIPAPLDPSVLAVIEDYPVPRTLEATTTKDDKSDGSKPRSNFTFGKKDENGERKLPKWLKLGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEP8</accession>
    <name>A0A2G8SEP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_05485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEP8"/>
    <dbReference type="OrthoDB" id="2766195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="766" mass="83988" checksum="540724BBE81EC285" modified="2018-01-31" version="1">MATTPSVMQLFPDISTPYPSIFSYYAHHSFSTARDEDDTCTKCGSRTILLTPGGVQWCICSLNAVDRQVSGLRRELHTAVDRIAEVESEHAAEIARSEKLRKDLRRSEDSTVRSYPIVAPPTDADKPQAVAQRSVADLERRLVVQVSTRNELNAKIQKLECRLLELQKEDRNLRDDLKAAETENGLLRDKGDRQTQEMTARLKGYESRLSFVESENDSLMSEVALYRGRCADLEMQIEEVAVALDVARTNYNNLEHQSEEEIARLEAGMRDRDMDIAAMQSTQAKLVDAEAQTSVESSAWQSARPIHVHATKLPDQHEYVELTELHVDSTELTCLNESSVSAEGRADQIAVEQLVDATEPPPTNDRADLLVDAPSPAIENLGTAEPPSTYSRTDLLVDATEPPPTNDRADLLVDAPSPAIENLGTAEPPSTYSRTDLLVDATEPPPANDCADLLKHPIAVERAGLPVDATEPPANEDLGMAEPSSTCSRADLLEHPVAVEQLVDSAQPTPTNGRAVLLEHEIAKLPEAPEHPVAVELTALRVDISLLVDVDLFRQAPAAGRSVSLRSLMPRRWTVDLPGDIVHALARLWVVGHSVQAERLLRDVTMVFHRVSAEESYYRSNTPPYPELQLISIDEGIAAPTSRVQRSFGVAHILLLLAIVYVGVVIFATRLVTPCLCEESAWNLANGGPPPNIVNMVWAAVDPRLSTSLPDTQFGTRNRVGRMSQSRAVSSSLSHSRGNTTSLSSPTTAKNLDEFPPSSLLTGIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEQ0</accession>
    <name>A0A2G8SEQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEQ0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="13224" checksum="BFBC13050EB7B599" modified="2018-01-31" version="1">MLLPLARLRPSQASLSLPLAIAGILLSQLLRLPPVLWRFLQTLVFDSERVSLASLGNVVLKLRSTSLGQRAPDGTEIEDKVHHEDTEMNSKGMLLKVARPKHGTSRRVPLPHALAPRQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEQ8</accession>
    <name>A0A2G8SEQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05501</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEQ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEQ8"/>
    <dbReference type="OrthoDB" id="2659442at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="346" mass="38246" checksum="C76800D34EAED114" modified="2018-01-31" version="1">MSKFRVLQMKKLNFERRTSSLRRRLSDHQRLIKVIGSQDYPRLSRILNISMTHGFGPLGITDHLKRAAAGVYAPRGHYTEREIDLAFLSKGIGGTRLLYALCKAYGMAARSTLAKVRKIPRVLPSVGIPTEHEVTFNIDAMFNPNVKPAPPKTVSGRVPGLVLQVDGIALEERCRYLRESHSIIGVCREHSIGLGLQVKDVESIRRVSDALHDPDAPVRCHYGKDGTVVAIAPYARSDHYSAIPIVVSASCKMEKGAELARWLGMVIDVWEKHESGGKAHGEVWALASDGDSAYRVAKHKLCMTEVVDPESALGVLMHCLPGLNCTTGRNMVIATCDPKHVIKRQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFU0</accession>
    <name>A0A2G8SFU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_05270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFU0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFU0"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL32567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="434" mass="46478" checksum="D0FB8D5FF99E7A6D" modified="2018-01-31" version="1">MSASPFCKQPEFETLQLHAGQAVDPTTKARAPPIYASTSFAFKDSQHGADIFALKSLDPVYSRIGNPTVDVFEQRMAALEGGVAAVAAASGQSAQFMAIAAIAKEGDNIVSTTYLYGGTYNQLNVLFARFGINVKFVEGSDPAKFANAIDENTKAIYVESIGNPKYNIAPIPELAEVAHTHKIPLIVDNTLGMGGYLLRPIEYGADIVVHSATKWIGGHGTTIAGVIVDSGKFDWANSGKFPEFTEPVAHYHGIKYAEAFGPAAFAVKVRADILVDVGPALNPFGAFLLLQGLETLSLRAERHSANALALAKWLLQHPKVSWVSYLGLPLHEHHREACRLLRSGLFGGMLNFGVKGDAEMGRAVVDGLRLATNLANVGDAKTLVIHPATTTHSHMSEKERLTTGVTPDLIRVSVGIEHIADIIADFDNALKLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG45</accession>
    <name>A0A2G8SG45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG45"/>
    <dbReference type="STRING" id="1077348.A0A2G8SG45"/>
    <dbReference type="OrthoDB" id="2631350at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="309" mass="35197" checksum="94BC47F0254866D0" modified="2018-01-31" version="1">MTNLPQPSDDEDEDYEPFYGCCRTLKHLVVRGTPGHIDLFLDNTTTCNLKTVAVEFLSGANQQLITDCIEHIAEDALLDHPVLRSLSIKYPYESYYDDEHASGNAGANTLRDATLPGVLSPALRIPFLRKVTLDFHTIPVLTDAGLLQMIDAWPRLTALHIAPPRERYESRVKLSPAVLVAIAQRCPRLAELTLPEIPLDAVPPEKNLPVVGQRALRRLRVTFHDRGREHALYTAALFLDRLFPCLALNPRFEQEVVEPPGQGQGYFRMSWEHDAREEARTWRRVEEILYMMQLGRRHREELKNANAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGS4</accession>
    <name>A0A2G8SGS4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase family Tnp2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SGS4"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040521">
        <property type="entry name" value="KDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18758">
        <property type="entry name" value="KDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1281" mass="144463" checksum="C182C29DA2AD2A86" modified="2018-01-31" version="1">MAPSSTPRTARATKKKCPCCGQDLHPETVSRHVRGKVNVRAQYRLPSPVSGRSHDADAHALPPPPPRPPSLSAGSSRVDPANNSLDSYGLDLSDAAAADLDAAATNLQESVWAGRTRSYRPPTVEDAEDDDDHDMGEGDAGGPELSLEDREVWERLHAEEQEVAEHEAISVWDELAESFLREGMISGEDLTEEDMRILRPFSLKVDKHIPSNTYELFLPTFPESKVATWKTAQAHVARLSGFQPESYDCCINSCCAFTGPHASLSACPYCSEPRYNPSGKPRKVFIYLPVIPRLKAFLANKPMATEMKYRAEEQARHTPGVIRDVTDSENYRTLLNKNVIVDGKTLSHKYFDDPRDVALGLSTDGFAPFKRCTKTAWPLILFNYNLRPDIRTHLDNILGLGVIPGPKKPVDFDSFLWPVVREFLRLSIGVHAYDSLKDAFFALRAYLILVFGDMPAISMVMRMKGHNGACPCRMCDIRGVRIPESRNPVHYVPLDRTRHPDILSNPQAVKTYDPAHLPLRTHADFMKQAKEVQFARSENDYERLSKLYGIKGTPILSALSSLSFPSSFPYDFMHLIWENVIKNLMLFWTGKYKDLDEGAENYQFPSAVWDTIGSATADSGASLPYIFGPRPPNVATDKVSWTADTRSFWAQYIAPVVLRGRFLHDKYYDHFVELVRLINICLGFDITTTQVDDVRRGFIGWVKKYEDILAAGPVWASWAFAMERYCGALGPAIRSRRFPYTSLNCFVLDHARLSQIRLLYGLQDTLPIRLTPKEQGEIYEKYDTRRLLPSHTIFTPDRSLTDKVIACLSTRFTALPAAVREALPTTFGQWARFRILPAGDTIRAADMVAPAEDGRDASFVRYELLVDRNARYRNRPTDFVSKTFWGQLRRILVVNVGPILSATPPETKSQTLLLAVIHTCTIESSHNVLDIHYYRNHGRTEVVDLNYVQCCVGRVKDRGRLAAAPARVCVTVFDPNPRPIAVRLAPIPPYLLIVTITHIIGQTGARESPHHDHHHPILPILPGDVDFSLDKLGPGTTFQAHSADYDMRTPFRYIYVDFAKVSALQRYLKLKMLVGSYDIYCQYIIHFRERLEAEFPPEMLDELESIQDVNIPDIVAAVGKYHLSMHKPACRPFFSLHNLPGACMDCGETCERLWGITNAVSRRTKEMSAGYRQDALNDLYGDHNVQRVHGLGVVSSRIVMTIAYLCILQGQELSRKLQIASERLKAAKEYLETVEASVEDRFSKHTLIKWRKAHVSWTRDVVDVAKHKSLENPFEPPVDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHA0</accession>
    <name>A0A2G8SHA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHA0"/>
    <dbReference type="OrthoDB" id="2800649at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="784" mass="86008" checksum="7B307022AFB0899A" modified="2018-01-31" version="1">MEKNLYLSPEGALADTCGILDAPEVPTPAPKVVVLDTDDVGYDTVTPSDYEPDSDWYSDSDSDSERPPAKRPKITPLVPRHSVDSHMLKSIRSRAQPIAQRSQSTSVGPTLAELRTRSDVPLPVKDWVALSTAIGLYAEDYRLPPHFAKAFPQLFATAVPSAPLTCPAAMTSSFSSPATLYPVPPRGDGSFSPLTQVLTLPVPASPVLGMLPPGQGNHRLGATTVGVKSVGPVDSDGEVEEADAVKSSSRSSFVGCDASLVDEDAHASDSDGSSESKAAARRKKTTPGPGDANNEDVLLASPEVTSWDTHASTNKMPETPRTSPFLHFDEGAHVNRPDLDDLNLDDPGYDTASTLDASDSESESEDEDCGAMPPPKNIPMPLSERTKTNWSPQPQRLVTPRSLIAMGQPPPFGPTIPELLIRDDISPAFRAWAMESHEAAFLGDRPLASAKFATQFPEVFFPPFLHHSCPDTYFASVESFPARYEFIYTSKLHPWTQTLEVPIEVFPRPDNPRNRFHTCPVEQSRDLSRNGDKQTVSHVPVDYEGSLPKIVASRLPTTIHDGDRWHGKFIPTILQFLGTQSKSPWCITVRDLPALQHIWVAVYGETLSWTIEVNDCVYVSVMASIREWRNCISDAAIWAFERFFQSSRKFSDFAARCQFCRAILHDSRLFYETFDAPFKRVTLAQHLYAIRGAVHVPSMYSSNVLKHPWGAIGLSAAAVYRAAFLFKSTQIRYINSSGGSHSAWENHLTFGEVAYGAKAKQYSFAASRLATHEVNMVVKAASAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI21</accession>
    <name>A0A2G8SI21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein prenylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_04022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI21"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="42944" checksum="2D2F796432B4F191" modified="2018-01-31" version="1">MNKNADLCSRLGDLLNVPPISIELLPGDASEWLASAPPEHAPFLFVDNNLGVPHKLAYKAYLEAVARFRAVRPRHDSIDHSHSAELLASSAVLLLVNPAHQTALNARKRLVLLGTHSAAHELRFTDALLTLRDGAKQSILWHHRRWVLRRIHPPLPSPSPSPFSESQAKGHGDGVDTLADIALSPATFRAEIAAVERACEAYPRNYHAWAHRFLCAEALVHVLAHVLSAFSPSSASASSPHDRHEALRELEAERAHIRTWVERHVADYSAMQYACRLEALVQGLPAPDTETKTKTETEKGAEAGAHALELVRAYSSHEALWLYLRGAVALDLFPPGTQGDAGAAIDGLTESYLREGATAVAGHQVVSGTYGHAVRFSAWRKWSVSPRVSNFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIF4</accession>
    <name>A0A2G8SIF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03027</name>
        <name evidence="2" type="ORF">GSI_04178</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIF4"/>
    <dbReference type="OrthoDB" id="2726580at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="560" mass="61007" checksum="484EABA11B2E866B" modified="2018-01-31" version="1">MPPRKAKPHPTSPTPFNQCRMTPVGVWSIVQHLRTQPLLTNIPEDRLFAMAIAFLAQGGTNDGQHHVEPGALHPSHYVAHGGEGRNWRDHLRRYFRITVMDHLTWLDRLSGGASIFVHLPGTRPPDTPAIIEEARLDVYYPPSIVRDFPTLNVVVARVVQYVAEGFAVLVMERWDRAKSLHEGGGLYDPSRPRQPSDRTVCEDLIPRSSTPYHVFPGRTPGTLEEIIARFLQNIPPPINPPLPAASATETAASATRSVTPNAHAPSASTVRSPRVFAPPNTPRVPKYISPENRPDVKLEYDSDKDPWTAEDLAVMVENMEGMQLRETPESPASELDELRRRVAELESIVTTQVQEIEHLHALLTRDMDMRSPTPRSQSAHPSTPSHTGTFGGNKGKGKNKSKGKNTPRNRSRSPSSLSSVSSVSSVTASSASPTPSRHAARLVPLFLQRGAQPATGAPRASHGSGASSSSSASQSAGSSRPSAPPTSSRGSNIIVGFFTDHCIVFHNLPNGAYGIIARIETEFPPERWLSAIRCFLPSCSEAVAQDLVEAMRQDSGLPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIH9</accession>
    <name>A0A2G8SIH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_04150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIH9"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="549"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="790"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="863"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="923" mass="103096" checksum="A1D45A7879072A7D" modified="2018-01-31" version="1">MPLRPPSTAGRPSSARPDTAHTGPISPFYYDREPQYTYEYDIDEEEEDDDDESDAGDVFAFGPPPTAASPITPPPPTFDPASVDRSAPVPGPSQQQPPYPRHPYPLSPVESPPSTDSQNQHDHDDAYRLRRLAPTTAVSTPTTGNTGRFTGVSSAISSREVHVSLPTGDESTGGKGKDRPPSTTRSMSFPSVADSASIKMEFPFEDEDEDSPYPEVRASVSNIDDTEMPAMTLRMWFIGLVLTLAAGCANLFFNFRQPAPSIVSNVLLLIAHPLGKLFALTMPIRTYRLPRWMGPLGGYEFSFNPGPWNIKEHALVYIMANVSIGVPTALNAVVVAELDYNVKLGYGFNALLILATQLTGFSLAGLCRRYLVWPASMVWPQNLIVCTLLNTLHAEEEDARGGITRFKFFCYAAVGSFFWFFLPGYLFTALSVFSYVCWIKPQDVVVNQLFGVSGGLGMGILTFDWAQITWIGSPLMVPWWAEVQIFAGFFLVYWILCPILYYTNSWDLSYFPLMANVPYDRFGQLYNITRVLTADQSFDPVAFDNYSPLYLPASFAITYLIAFALSSAMIVHTVLYHGKTVLHGLTQTRLEKDDIHAKLMRAYPEVPDWWYLLTFIACFALAIVTAEVWHTEIPVWALLLAIALPVTYIVPSGYVYALTGQNITINLLAQIIPGMILPGKPLPNMIFKAYAVQTLAEGTAFVQDLKLGHYVKLPPRATFVVQLVATTLVGLLQVGVKEWMFTNIPDICQPNQKDALTCPHNQVLYTTSAIWGLIGPARQFGTDSIYHPQLYAIAIGGVLPLPFWLWQRKWPNKWNRFINLPIVLNGIGLIPPATGINYSSWFLVGFIFQFLVRRRNFVWWSKFNYVLTAAFDCGTVLSVLFIFFTLQFPKGGFFVNWWGNTVYTRTADYAHSPLRVPPEGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJK5</accession>
    <name>A0A2G8SJK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_03659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJK5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJK5"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="108"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="567" mass="63604" checksum="F1C47A2C922E70BA" modified="2018-01-31" version="1">MDSEFRRSRWFTRGWTLQELIAPANVVFLASDCTVIGSKHSLASLIVEITNISYNALLRVEPLREFSVSERLSWAARRQTTRVEDRAYSLLGIFSINMPALYGEGEGAFRRLQEEIMRRIPDQSLFAWTPFHFDSPPSLHELDISDPQQSARRLFCFGFYQDFGTSSLLASSLDLFEDGWKIAAISHDEVARRLQLRSSTLPATDYSFTPHGIRTQVPIIPLSPYLLAGTAEYHPDNIPPSRWYLVVLGCEHKNMGGHLLCRICYIPPSESAIELLHCGRMSTVPSLESAREFDLLLVSPDTIQRLRPRKMDFKTVYIFHPDLGDDALEVARRQPHDTIRLVLLKKTRDALSALGYTSDLRGPNQARPNAHWLILSDDSDSRTITIEYEHTLKDNGLSLEIEARVAMTGGPAEPSAILPRDQESTSSIRIRRVSWNDSCPWDQSRNMRTQQIMMSTLAARPKSLTLNLGLTFAAKDHYAIHVEVLRDLTSTATSSGTSSLSQQLMRVGKRGSDAVRDYWRDAAARRNIAPAAVDLRSTPRTRTTRGRPKADERDGGPAASGPSGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJY4</accession>
    <name>A0A2G8SJY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_03785</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJY4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJY4"/>
    <dbReference type="OrthoDB" id="1405595at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="88"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="153"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL34074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="840" mass="93196" checksum="3CC649CF9909C7E1" modified="2018-01-31" version="1">MSPDPVPPQLAEDTVLEEPSASASTSTAASASTGSRISKNGSVSKMRSHRGNIPTLPQTKFCPLCPAKFTRTTHLNRHLKTHSNERLHECDRCHAQFTRSDLLTRHKRTCADSSANRSRRKSCQSCADSKVKCDLGRPCSKCKARGRECVYSYGASSSSPEETTSPQNVPSTSSPESGTTSQAASSQQDASPNAMTFPEESSSSPSSIPNLTAPPDLLNNTSPASSFSSPTDALDASATLGSFTQSALVSVPRGGSSTTGEKGYFTELVESEMYDNLFSDVFTSTFQKNPTVPGNHFNFDATSILTDRLESASIDQALFDQVFGTQSTSLAMYPNLSDPVFPLDPLESISEQEIVEPPPPPTQQAVAVFEPEMPSVAEYYQFVMAFLTTYVWHMPVVHLPTFLSESRHPALVKASKACGAMYSNTVSATNFIDRVLATVRDVIIADLSHTTDYDTIIQLTLASGMIQTIGMFHKDPEQRAKSNVYHGMIVMMLRMNGFVDKTRDWKVPDIDFNNPASVQAGWREWVRFESAKRALWICYLHDCCHSIFFNLSPTFHTEQFTLGLPAEDSLWTAKDGAEWAAILNTPSPYGDMETRLRGHYLKALYFYIVQNNPGNDPRPFHITPFGHFIMIHAILRKLFEMYLRDRLHFHQLGDVLGRSKIKPHFVDRDRVFHVQIMLHSWLQSWLQSPETPRDIPEAQQRFCFNALPYYWLAQVGLVAYQEGLPPFDPEGTYITSHEAKFQLVKKWEKHIRKFLETGEQTPTMFWDEVMKVRIENWQQESGFHYTHLLGFFNGQVRADPAIVAAAVAAQTEAAAQATAAGEALAAAARASGSGSGMPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJY7</accession>
    <name>A0A2G8SJY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJY7"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="431" mass="47981" checksum="74548F35DBECCA50" modified="2018-01-31" version="1">MSKTSHRCSHNTTNANYDYLNRTGVEQHLRSTKNVGWGNAFQELLLNAYLTYKSGRTFVFANYTWNDDGSPYTVSFNRTIPSQIPYTALIRGPIVGEPWGPRYEHVPAAVTRTYFEHICPSKSELTQEQVHSSIPYASNTETIIDTWSKAINNVTDPCLQMQKSSGQIFDHWETFGVPGNLASIWPDLIATPLLTHFTWSPLIELAFDVNRDLFLPQSSLANTPYLSSLPYDSSAPTATTTNAARYPLIPGLMAIHIRQGDYSSHCTTLGSIGDPFVSVNSFPSLPDQLMPPGNRTSHGKLPVEWTGSPEQLEYHHRRCFPSIPEIVAKVLEVRSAPVGAGVRRIHIMTNGKAPYIAQLKNALKDAAEWDSVSSSRDLVLNWEQKFVSQAVDVLVAQRAQVIIGNGFSTLTSNAVIMRLANNFSTDSIRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKM6</accession>
    <name>A0A2G8SKM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKM6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKM6"/>
    <dbReference type="OrthoDB" id="3240925at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="229" mass="24050" checksum="030D084D43FC7951" modified="2018-01-31" version="1">MGLSEFPNGRRMHTLKRRKLTHSTSPIISNSTLSLPNLPQLGAKAVVCASCHRAFPVARQSQLIQCARCHAPTCTICSRTCNGCPPSVPPTPELTMSPDTVSPASPAACSPDTTPASLSLSASVSFGNLDGPDTLGLGGGRRPALAPHTNVAAIGTAGRRRKNREHDDADEDGRKGSCEAGHEDERMQETGIVPGCGRVVCRGCSFETPESDLNTCYDCAGRSTPPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKS6</accession>
    <name>A0A2G8SKS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKS6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKS6"/>
    <dbReference type="OrthoDB" id="3335528at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.20">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="34241" checksum="BB63B8B65A603272" modified="2018-01-31" version="1">MSIHSVKRAQTHLAWDNSIAPVIHVSSGDTVTFDCLDASNGQITASSNAATLASLNVSLLDQVNGPVHIAGAQPGDTLRVDVCGLETADWGWSALIPGFGLLADEFPEPALKVWKLVRNSAGKDVSGNGEYGYAWFNEEKGIKVPLKPFCGEMGVAPGKDGAHSTIPPYATGGNIDTRHLTAGSTLYLPVEVPGALFSIGDGHAAQGDGECGTAIETPMKVTVRLTVLKEKPYVKTPHFTTRNPHAGTEEFYCTTGVDSDIREATRAAVRNMITFLGVEHGLGAVEAYMLCSVAGDLRMHEVVDMPNYVIGIMMPKSIFTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL23</accession>
    <name>A0A2G8SL23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_03219</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 21">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL23"/>
    <dbReference type="STRING" id="1077348.A0A2G8SL23"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654729" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="21"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="21"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="245"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="251"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="523"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="556"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL34443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="617" mass="63464" checksum="2B5589415EB65A24" modified="2018-01-31" version="1">MRSGRLSVFFSSVLAAQVAAHGYVKIVTIDGTAYAGNVPYRAPSTDSPIRLINDVDPVMGTSNINLVCGQGAENGAAVVPANPGSKVAFNWVSGTGGNWPHNTGSLMTYMARCEGTTCDKYNATDANWFKIDQAGQRTDGSGWWMADIMQGKSYTVTIPAEIAPGDYLIRHEIIALQRAATLGLVEFFPSCTQVRVGGSGTGVPSPTVHFPGAYAETDPGLYTPDVYNPGFVYQFPGPALVTFSGSGSGGSSTSESASPSSTVSPTSTDVSTAPSSTDSSTVSATSTDSATVSVSTDSAPVPTSTDSSAVSTTTDSATASISTDSSAVPTTTNTSNSVPTSTDSDSCTDVPTSTADSSTVPTSTDSVTVSTSTDSGSHHRSSSRAPSSHAHSSHRVSATHRSSHHVSSTHRSSHVLSTSLPSSTATVSEVTSMPTVALPSSTSTDDDCSDWEPTSTAPVSEVTATPTPTAAPPSSTSTDDDCTDWDPTSTAPVSEVTSTLAHITPTVAPPSSTSTDDDCSDWEPTSTVPVSEVTATPTPTVALPSSTSTDDDCSDWDPTSTAPVSEVTSTPTPTAAPPSGTSTEDDGDDCSETESEPHYTSHPSWPHRMARIRRSHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMW8</accession>
    <name>A0A2G8SMW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thiamine pyrophosphate enzyme central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_02705</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMW8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMW8"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="6">
        <location>
            <begin position="171"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL34918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="414" mass="45593" checksum="A8D214F3526C00C7" modified="2018-01-31" version="1">MARLLSRSSPVLTRWSRSAQPRVTRRSPASPQRLSCTSMSEPRVSGARSTMSIADTLRSSSSPAMRLIQSDRRLKGTKNEWPMWHQDVPDQPSIVRQYMRYTAQIQSGKNARQIVLRALQITTSHPKGPVYLWARRETTEEEVDESIFNEKVEFSKWPSVQGGGLPDSALNTIVDALLTAQFPLIITANAGRNPATVPLLAQLSTLLAIGIYTSCPMSMCIPWTHPHYIGTAFGGKNDLLPHADVIILLELDVGWVVAAGNAPQPGARVFVVDSDPLKMNWGWQHVDAELLCKADAETALTQLVGALDVPAAKAKVESDLVASRQARLKELRAAWVAAQEEAEAVTSLAEGSPTVPYVASTLRQAVAAQTASRGEKVLWVNESISNYPLVWTHLRRLRELARSRNGTIRCQRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMY3</accession>
    <name>A0A2G8SMY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMY3"/>
    <dbReference type="OrthoDB" id="3032208at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="226" mass="25985" checksum="C40BD20FEE68ABF5" modified="2018-01-31" version="1">MRDPRTRGASRRRQLLHIPEEGDNVTYTNSQRRVILTLVNSVFDDGHRALFSRLAMALAPGCEPAYVTHPTPQAFRPRVVFVWRPLPAAEQSLLRAQHSVFFSIDTTPPLSVAHLTFTLLHFTYTAIQTHVTADYNFDPRRLPRMTHLAYHITPGPVYGIAYFDNLHHAFADASAQGLQLTPNHARPLTVITTWPPDVHELLLWAHYHSWRLMTRCNRLCRMMTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPA6</accession>
    <name>A0A2G8SPA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_02332</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPA6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPA6"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="43"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL35604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="463" mass="52574" checksum="3EE051ED48ADAEB9" modified="2018-01-31" version="1">MIPEILFNAFIRVWEYLTFWWYSPPALSNMRLKGPARDGNENELMIQFFTWEAEHPHMSWWKHFETEVPNLAEMGISQVWLPPPNKAMRKQGQGYDAYDLWDLGEFYQKGTIATRWGTKEELVHAIAAANAHGIDVLVDAVLNHKLGGDRLEKFNATPVDPNDRLRDIGPTREIEGWTGFDFNGRAGQYSSFKWTHDHFTGLDWDHRTRTKGIWRITGDKHEGWSDWVDSENGNYDYLLGIDIDPRHPDVRKDLMKWGSWILQTTGGAGFRLDAIKHMDRRFLLSFIKHVRETLGRPDLFSVAEYWSTECVFYGDLYPNEECYDPSIAKGLKRLMEARKNFAYGARTDYFMHQNCIGFVRRGDREPGTGHGHGGCAVLISNADSGLPEQQESGPPVATSAVPVHTLRMNVGSENAGATYCGHVSPGNPEEVVRIDADGWGAFTCPYGGLQVWVRASIDNGTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ03</accession>
    <name>A0A2G8SQ03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ03"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ03"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="395"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="567" mass="59940" checksum="396F4D593B3ADC6B" modified="2018-01-31" version="1">MAPAAPPDMQAPQVRPRAAAVLAPSDRQQSAKGKEVAAEPPSAQPAEGPSADEKSSPPAAAADAPADVGNGHASSPDPSPSTPPPHPSSHPPPPEQADSAGQAPSSSPTPAAVRSAESIPSAQEKTDENGTVRKEKGSLESEQTGTQTFKSSPRKDAVKSMSDGAHTSTTDADASPTPRPKGNLLSKLFRVLVPCVGPSSRAHPIDLHEKALAPAPHVPAPAKTNGAATSGLKEKQAAKEAEELPPAPEQQEQAAGGVASTPDDAQASTSAQEIPPPLQPIDIPPPAEDPSVIVPPTPTRTLPLEETEGVTSGAVQPPGSTGDESIHNRSRRNSREMGEESDGSTSFTEDEDLEDGTPVDEVEDEEERLIMQGGAGIPIGLDGLPRPLLPPISPKHAGRKCLVLDLDETLVHSSFKSIQQADYVVPVEIEYHWHNVYVIKRPGVDNFLKKMGEIYEVVVFTASLSKYADPVLDKLDVHHVVSHRLFRESCYNHRGNYVKDLSQLGRPISDTIIIDNSPASYIFHPNNAVPVSSWFNDPHDTELTDLCPFLADLGQVDDVRGVLDGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ31</accession>
    <name>A0A2G8SQ31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ31"/>
    <dbReference type="OrthoDB" id="10512717at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="66" mass="7021" checksum="096DD440D6EF22B5" modified="2018-01-31" version="1">MLPVVVQNIIKYMPIMAFQGLQAGRDHAHRSSSPFSPGTRSARASPRSDTPVQTKNATNTGARAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQF8</accession>
    <name>A0A2G8SQF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_01613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQF8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQF8"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="9">
        <location>
            <begin position="48"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="10">
        <location>
            <begin position="657"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="803"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL35953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="847" mass="95271" checksum="996C2ED7123295B4" modified="2018-01-31" version="1">MAVEASRLPPPTFRLREEELPPELILSIERILELHTTSDSDPFDNLANDFNSVALLNQYFPDEAALGQLEAVQARLAQSERELQAEIDALREELRKDQDPSRMQLIQEMISDLLGQMSRIREKATESEAVVRNITKEIQVLDLAKKNLILSMTTLKRLQMLVNALGQLEDQIKERKYGDIKQSLAAVKQIGQTFKPYTSVPRIAQLWRRIQEVQNELRPMIDQDWDKFYVQDPSKPIKSSVVTDACLVLDVLGPDVRAQFVERYVALELKEYRRIFRATDEAGQLDNLSRRFAWFRRLLHTHETEQGRVFPAEWRTGWFLTAKFIEITRDDMTGLLSKAGSKLTVKQLLDTLAETMEFEASMVKKYSTPLRDILKATTPANATRQSKPITSAFEAHMGVYIDSQDKILSDMLSQYRGSKSRSSLEAASTSSTADDEGATPVLVLPSSTELFYFYAQTLDQCARLFTGQPLYDLCALFKKWLRIYAEEVLVQSLRRPTNFTRKSVETRHDPAELKNACTLINTADYCQTTALELEENIREKCDEAFKEKITLQEERDLFVSAISAAIGVMIRELESACEPHFNTLSRTPWSTVKQVSGQSVYIQDLLRAIEQIAETVKPVLEQKKYARNYFDKISSTVFAKFTNALVRSRPLLEIGAEQLLIDLQAIKACLLKIPGEALSTSNYTKSVSKHTTRLEALLKVIVTPVDPAEGFILNYTLVIGDASFSNFQKILDLKGTPKSAQNGLLDTFLTITSTKADLENTSFLSSLDMDPAMVANMTSPANSRVSLIPGAAGESILAALSSPPLSNVPSTGSDGTNKSDQSSKREVFSDFKRFVSFGLRRETLPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQS0</accession>
    <name>A0A2G8SQS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_01775</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQS0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQS0"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="129"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="388"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="838"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="936"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL36115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="948" mass="104424" checksum="D1C37769071A11A1" modified="2018-01-31" version="1">MVAAKRKRAEPPQSDSEAEYSEVSLGSEDEIDISSALTGKRPRVAAKSKKLEADDDEDLQEFIRESIAKRDVKEGTELLKKTKGRTKIVKGEVGGGSFQSMGLYPWILRSLTLQGFRIPTPIQRLSIPALLNNPPRDLVGMARTGSGKSLAYMVPLVQRLGGRHSATFGARALILLPARELALQILKVGKELARGWHAGEGDHAGDAQDADESKKGQSLRWGLVVGGESMDEQFEMISNNPDVVIRIIATPGRLLHLIIEMNLDLKSVQYVVFDEADRLFEMGFQTALTEILHRLPAARQTLLFSATLPKSLVEFAKAGLQNPKLVRLDAETKISADLKMAFFSVKQAEKDACLLVLLRDVIGVPLGSTPTEPDESTDKKGKGKGKAKHSSEHAAAPHQTLIFAATKHHVEYLTNLLSAAGYAVSHIYGSLDQAARTQQMDAFRRGRTNVLVVTDVAARGIDIPVLENVVNYDFPQGSRVFVHRVGRTARAGRQGWAWSFVTASELPYLLDLQLFLSRPVRNEVSGTGDQVYTESLILGPFERDKLDEEVAYIRKLDEEHHNLSTLRDVMRKGQGMYERSKGKASPASYHKTREMLKDGRWGYAGTESGVHPVFLRRSPDAAAKLAEEAKRRALLKLVDAFRPAETIIEVGARGNAETAALMKQRRKALSKAAQRASLASTSAAALVADDEEGDGHGRDGDESGEEPEMANEDDIAAVFDVSGKKSKSGKGGFRDEEFYMSHYQKDADTEKGYSLRDGASFAEQARNVAFDLTGDEAAAQERQRRELKWDKKKKRFVKGTGEGADNVKLVRTESGVKLPVTYRSGRFDEWKAKSRLSLPKVGEAEPDGPRISGRGGGGAGGRKYRHKQVVTAKPLDRLRGDYDRKVRQLKKGPQDGEGAAEEGGQVWGKPMGKVKSELKTVDQIRKSRKVVEQKRLKNARAPRKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQW0</accession>
    <name>A0A2G8SQW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQW0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQW0"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="144"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="313" mass="34788" checksum="F40BD9E89F365B74" modified="2018-01-31" version="1">MESLRYLGSMAGHKGWVTAIATSSENPDMILTASRDKTIIVWQLTRGDEVQYGYPKRILHGHNHFVSDVVISSDGQFALSSSWDHTLRLWDLNTGNTTRRFVGHTSDVLSVSFSADNRQIVSGSRDRTIKLWNTLGECKYDIKDDGHTEWVSCVRFSPNVMNPVIVSCGWDKVVKVWELSKFKLKTNHYGHTGYINTVSVSPDGSLAASGGKDGITMLWDLNEGKHLYSLEAGDVVNALVFSPNRYWLCAATASCIKIFDLESKSIVDELKPDFAQSPNAREPECVSIAWSADGQTLFGGFTDDLVRVWTVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR31</accession>
    <name>A0A2G8SR31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR31"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="157" mass="16014" checksum="692BBBF969E9623A" modified="2018-01-31" version="1">MGPRPCASRASGLPEGPTFAASSAASGQAAVTASLSAARRPGPGAGSRAADASPQLPRCGRVAAGAEKALVRMVIAKLGAASESSRQDPHLPPRLNGIRRVAPTSHALCTSCPSRTTAVWATRAPAAPLGCADCLLGLYFAERTWRALGCCRVRVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR81</accession>
    <name>A0A2G8SR81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR81"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR81"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF4">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48187" checksum="C737E622B5B7F06D" modified="2018-01-31" version="1">MHTLVSQAVLADLAVDRSTTNALLSTFFGALQGSISVLLTLFIGYLMARRGYMDHRTVRHVAKLNTDLFLPCLIVEQMGPGLTARRLAVDWIVPLWGLVSSVLGHAIGYAGKRALAVPYWTIVACGRPNANVLPLLLLQSLEHTGVLDTVSRRGESVAGTLRRAKGLILLNAVVQETVTFQFAPGIIARDRATAPSKPRHSDSHDHDLEGRAGVDAGEREREALPPDPRRVPSDLRDPGRVGWLEDEVIGQGHSGRASGSRDMHGLDDVVEHQGPSRYCPHPLRFLERPTKVFHHYVSPPLLGAVLALVIGITPPLHHAVLDEDGTLYSSATQTVVNLGELFPALQAFTVGAELALVRSTHPGARATLWVLCVRFVLAPLLALLLVWCTAGRGLYVDDRLVWFLLVLIPAGPSAMVLVSVAELVDVDQGDIAGYLTVAVRLPPSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRP3</accession>
    <name>A0A2G8SRP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRP3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRP3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="45"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="789"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="892"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="804"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="961"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1136" mass="126607" checksum="575C05D2EBE3FAD5" modified="2018-01-31" version="1">MLQKSSVPIYTAKCHDGINITNWEEQSHPASRATRTVDRSTRLLIVSVGKKADDHVLRQSLASWVHEGIDRNGEAYRFLGYTESQVKAGKLIFFREGDDWTVQRLLESFGDLPAVYLKSGYGKYAARLGLSFSSTVESLDIPHECAIEIPDLLAPDGSLHSDGCGMIRDTFAAQVCRRHDLPPDTTVFQVRRGGIKGLLVRYPDDAFDRHCKKHPHARSGHFMIAYRPSMFKYGGGPTVLELNNHNSPPGAARLNIQFTALLLTLGVPLNVFKRLVQDQLDLIASILTDREKALEYIRGDLDAAAEDEFVQGLYSMLLARHELSEPYMRQRLQAFQKMQFTTLRNKMSLRIHESAYLFGVVDEEGVLGPDEVYVNLPSRSGVLVRDVIVARNPCYHPGDFRKLRAVDHPLLRHHRNCIVFSATAAHSVPDTIASGDLDGDLYFVCWNPSLIPPQEAPPFNRAPSATSAPTPAQRRGRQLSDMPQAAIDTFMQLKFSRLLGMMSNEWTRRVELMPELADSTFCRELVPLIESALDIMKSGEDAAKLEKRFKMLRSRHAQASQNPDGYRSPIQQLRDMIPQGNNEPLKDLNGLQDEALILREEDPARWQFHVSEAAKALPSFNQELSQAIRVDQESAENFGSASQHSQDRDVPRHADRVKQLYQSRYFGGGNEDTRREQRMRASAWYYYGYAKDRPAFAWLGERYLNEIKAWWTNGNRPPLFVGAAIPRPIITSSASLSQGDSQATLLGQPSSTQQASSRTKSTDEVPMDIDSETIPEEVPLATKIREPVDCRTRRRPAPQNAAETRGEQSRRCTTEPVERLPGVPVATNPKPRAPVATRVRIPPTRCSTASHEWNIISSNGTARRYLCACGIEVREKKEKGFWVSVQYNIGELREPNHTPRQPRRPHPEPEPEPDEDDSPPPRRRRTSSLSTVPEESVQNDDDDDSSSDSDSDSDMSLYVSADDRTARIPVEELLPPSPQPRRSSTPRTSGASDAPSSLLELSLRRLPARPGSDISSPVGRPRQVSASSARSRRTSGSTAGFCTPASPPRAVLAGSPSSSRSSVASPAIAAAWPLVAENPKPQAPVATPFISQCPSGVAHNWKVWGNQTHRKYTCRDCGYVVKERKTGTPEVWVPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRT1</accession>
    <name>A0A2G8SRT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRT1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRT1"/>
    <dbReference type="OrthoDB" id="284473at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033925">
        <property type="term" value="F:mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032979">
        <property type="entry name" value="ENGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005201">
        <property type="entry name" value="TIM_ENGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246:SF1">
        <property type="entry name" value="CYTOSOLIC ENDO-BETA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13246">
        <property type="entry name" value="ENDO BETA N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03644">
        <property type="entry name" value="Glyco_hydro_85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosolic endo-beta-N-acetylglucosaminidase TIM barrel" evidence="1">
        <location>
            <begin position="74"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="762" mass="82937" checksum="8F46AE35F748E6F5" modified="2018-01-31" version="1">MPILGEGHSSLVSEDTPFFRSLVDLDQWATSPGVVLQKHEGVLPYIPRSNVQGPLNLSTRGKLLVCHDYKGGYNESPTAPSYTFNFWPYCETFIYFSHHRVTIPPPGWSTAAHKHGVKMLGVLIFEGAESHGECLQLLVGPLPRQTYGAAKPNSNQTLPVSPHYARLLAELAYQRGFDGYLLNFEAPLPGGVEQARALTLWIALLEQELKRKVGPHAEAMWYDSVVVNGQLRWQDRLNSINLPFFLPSTSFFSNYTWPHPYPSMTAQYLLSLDQSTAPRPKLLSDLYIGVDVWGRGSHGGGGLGCYKAISHIDPECLGLSVALFGQGWTWESEQDKPGWSWAAWWAYERTLWLGPAALGEHVDVPPHEPKKGEPPCEHGAFRPLVAFFPRLPPPDPAVRPFFTAFSPGVGWKWFVRGTRVFESETGWTDVDKAGSIGDLVFPRPTLAWEDENGDREEAVPAATADISMDDAWLGGSSLVVSVSVLGSDADDAFFRCVWLPIQSLAITPRKSYRLSIIYKLSGPVDADIGASVKSLAPDLDASFDVTFVPASSDAPLPGGWTELLVDFTLAAATDIAVLSAAGLVIGFTCEDPTQPVAFTLTVGALSVSANPPSPRHTLLHPKIIWAHFAPDSTPKTHPLAGVLTWGTAVGMGPVPALTLTSPEDTDAAWVLDVHPAAPTFSYFNVYVHAYPGEGAAYAPETAAFVGTTGLDGRANRFYVDPACLPPELKDGGVSKARFYVQGVTDRGRVVDWEDCAFVDVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRV1</accession>
    <name>A0A2G8SRV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRV1"/>
    <dbReference type="OrthoDB" id="2734101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013668110" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="146" mass="15136" checksum="CD4E9051F0128AAA" modified="2018-01-31" version="1">MKFVLALVAFAASALAQHIEIGAPNNFAEVKAGSKMTVEVAQPNSLTGSTTVGIAIGLWPCGGPKGTSKCASTDVSQVLGNVVYTGSYKSQYDSTQPSKPPHQNFEITVPSSFSKGEVSLGIAHLFLVGAGSEPVYEFVNTTVVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRW2</accession>
    <name>A0A2G8SRW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRW2"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="106" mass="10838" checksum="610B3FDFEBAE107B" modified="2018-01-31" version="1">MGRSRLCVCASGRTVVQAKEAGGEDGLKLGVGGVGAGVGRGVCLDALGERVDDCPVRRERRQAEVECPAKTDGGQGGGVVALGHECLQGCVQRGVITVLARQYSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRW6</accession>
    <name>A0A2G8SRW6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Blue (type 1) copper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRW6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRW6"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013614234" description="Blue (type 1) copper domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="20693" checksum="CD6E16EFE0910AD6" modified="2018-01-31" version="1">MRFATAATALALVSTAFAADFVVNVGNNGSGNGLFFSPNSITANVSDTVTFVFNTNGTNHTVVQSLFAKPCEPAAGGFASGYIPGSVTDPKNFTLVVGDTKPIWFYCAQTTRTHCIAGMVGAINPPASPATNDLSAFVALATGASSIVQPTQLTFAPLATATAIVPSAASNTSATSTSAAKGTNAAAPGAKGVSGGVVAALAAAFGVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS24</accession>
    <name>A0A2G8SS24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS24"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="180" mass="20697" checksum="15E5439E3797EF0D" modified="2018-01-31" version="1">MLPRQLVQELDIGLLYSEAPTSDEVEEILAGAQSQALVQVVRHHRPDIILLEWSLDSPLERHSDCRMVTLKIKASCLIDAILLPPDPLEMRILEWDQEEECLEALLLEEEMEEVEEEEEAVEVEEILEEAFREEYLDDMVVGYHLREARGRYDHLISSQETVTSPKPSLTHYGSSSLETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSB8</accession>
    <name>A0A2G8SSB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_00355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSB8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSB8"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL36666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="186" mass="20981" checksum="2730D0E1D995DE5B" modified="2018-01-31" version="1">MGIDIKKHHVKKGNRTAPKSEDPYLLLLVKLYRFLARRTDSDFNKTILHRLFLSKINRPPVSLSRIVKETANAPERDSKVIVVVGTVTDDVRLLEVPKLAVAALRFTTAAKERILKAGGEVLTLDQLALRAPTGSNTILLRGKRNTREAVKHFGMGPHKHKKPYTASKGRKFERARGRRKSRGFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STQ9</accession>
    <name>A0A2G8STQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00849</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STQ9"/>
    <dbReference type="STRING" id="1077348.A0A2G8STQ9"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="169" mass="19747" checksum="2F00701D81F4321A" modified="2018-01-31" version="1">METQGNVDRQSILRATEARLKTLREKTPSRVLYMPHDEEHDRRQAFRKQADYILGANKPAQAIESLKAEDYSSCYVYSAKTYNTLRTGSAIIEEILEREIKKQETEVQRRQKEEEEQKELIEKLRNQFFDDRKSVAVRVQRERETGVQEKGLPRRKGAPLTSNIVTLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU10</accession>
    <name>A0A2G8SU10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU10"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="241" mass="26000" checksum="43262CC183AD53A4" modified="2018-01-31" version="1">MSTRLVTNVRPQASTRRPLPGSAASGPASERVRPHPPLPEASHPFHRVLFTPFPIGVTEGFQRTVSVPADPFSTSKRLPFTQTPSFISANDAMRDIFAQRASNQSKKGSSSVPSSPQQHPKRAHAGPDEDSDIDLEPLDDDDLDLNLDEDEDNAATASAIRKKREEQAKRQADKAKREIKPLKRSASRGAATQSLPASMFRFSHEPAGTQVTPAVAKIAEEDDWSESFGASGAVPTASLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLN2</accession>
    <name>A0A2G8RLN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_15115</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLN2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLN2"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="2"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL22427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="891" mass="98655" checksum="BB951AE7F0D0E0D8" modified="2018-01-31" version="1">MAYVFKRAEYGPLPLDGRKERVQFDKITARIAKLCYGLDKDHVDPIGIAQKVIAGVYAGVTTVELDNLAAETAAYLTTKHPDYAILAARIAVSNLHKETKKSFSAVVSDLYHYVDPKNGKPAGLISKETFEVVQANAEVLDSAIIYDRDFNYNFFGFKTLERSYLLKLNGRVAERPQHLLMRVAVGIHGADIERVLQTYNLMSERYFTHASPTLFNAGTPNPQMSSCFLVCMKDDSIEGIYETLKDCAMISKTAGGIGINIHNIRATGSYIAGTNGYSNGIVPMLRVYDSTARYVDQGGNKRPGAFAIYLEPWHADVFEFIDLRKNHGKEEVRARDLFYALWIPDLFMKRVESGGKWSLFCPNEAPGLHEVWGDEFEALYEQYEREGRARKTIEAQKLWYAILESQIETGGPFMLYKDAANRKSNQQNLGTIKSSNLCTEIIEYSSPDETAVCNLASIALPSFIEDGKYNFKKLHAVAKVVAFNLNRIIDANYYPIPEARRSNMRHRPIGIGVQGLADALMALRMPFDSIEARKLNLQISETIYHAAVEASCEMAQADGPYETYEGSPASQGQLQYDLWGVTPTDLWDWASLKSKVAQHGLRNSLLIAPMPTASTSQILGNNECFEPYTSNIYTRRVLAGEFQVVCPWLLRELVELGLWNDDMKNMIIANNGSVQNIDIIPDDVKAIYKTVWEISQKKVLDLAADRGAFICQSQSLNVHLQAPTNGQLTSMHFYGWKKGLKTGMYYLRTRPAAQAIKFTVDSSYLKNAVKKPQAKAAGAVTPVAPSTPIKEEPVTPSLATPISNGRINGVNGTNGAVASDPPSPSPVATVASDVALASAAAQLSLDERTQKAAEADPEFAAALQRQRDRELEQAKLMCSIENKEACLMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLX2</accession>
    <name>A0A2G8RLX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_15203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLX2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLX2"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="261"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="305"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL22514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="397" mass="44188" checksum="076015D2EE217A9B" modified="2018-01-31" version="1">MVRVWAEKEMRNLKRLRTAGIRCPEPVEVRENVLVMTFVGDKDGWASPRLKDADIPEAVFPDLYVELMLMTRKIFTECKLVHADLSEYNILYHIDDTPPGQCSDTPGEADEPATEEQPPSSPRGHLHIIDVSQSVEQDHPHAFDFLRSDLHNIEDFFSKRGVRTVGLRRAFEFVTRERLDPDDTDKDEEKEATVLREWMDTPEAADGEAKASDDAVFMRSYIPRTLNEVFDPERDVGVLSRGEGANLIYKDTIGIVGPKEGRKAEAEVEGGDDRRGAAKAAPAIAKPRVLGDGTPKKAVTFAGSDVEEGSEEDGEAEEGSVGEGDDGSECEGSGEAEDDDAGAEGFKDKKPRGHRHEDKEEKKQRKKAAKEEAREKRKHKIPKAEKKRRVKATARGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM88</accession>
    <name>A0A2G8RM88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15313</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RM88"/>
    <dbReference type="STRING" id="1077348.A0A2G8RM88"/>
    <dbReference type="OrthoDB" id="2720823at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34009" checksum="ADC2913ABC0B6300" modified="2018-01-31" version="1">MSETHRPGWAKPLDPSFYAPDDEEKAFMKATTRIQDDEELKTHIIAIQTKAFEHYKYPCIRMFEFMRLKIARLPAYPQFLELGKQRDGAIFLDMGCCFGNDVRKATLDGWPIQGAIASDLSKDLWNLGHELFRSTPESFPVPFLKGDILDTSFLSPAPILPTSTIPPALAAVPLNEMTSLSQLHGRLSAIFTGAFFHLFKFDGQAHVARLLAGLLSPLPGSMLFGVQGGRAVKGEWRPAEGTRMNAHSPESWRELWEGVFAEVGARVEVKARLRKEIGGMSMFGTYPENTEHYHVLEWSVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMY0</accession>
    <name>A0A2G8RMY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_15557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMY0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMY0"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="185"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL22861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="316" mass="34258" checksum="46083202D2E16A72" modified="2018-01-31" version="1">MATTALEKGKGRARPEDLEDDEVEQTSAASASSEDSDSSDSDSDSDSSDDSSSDSDSDSDSGEEVTQEFLDALLERARQNARAKAKQAAVAAKGGEDEFIHLGSDDEGEEKKQKPLPPLDTSSLPAPYITLPETRTAGPSKLRDPDVELVHKAASSIQAPAAPAPPPELTKDGKRLTKKEMKKMKNKTAGPSWFDLPAPAEADLPRLHREVEALRLHKQLDPKQFYRKEPGEGKGIKGLPKHFAIGKILPTDTPFGGGSADNLPRSARKRTLVDELVDDAEAKSYAKKKFRELQTVRGARGRGTLAARKALRKPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNF7</accession>
    <name>A0A2G8RNF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_15543</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNF7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RNF7"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL22848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="269" mass="28867" checksum="312B1C728352A7F4" modified="2018-01-31" version="1">MLGTAAYVIVHSEDMFAPESIDLLQKSGIDLQRHEEMGIEPNDFAELMITSGLVLTPDTKWISFHSGYDFGYFVKLLTGQSLPTNEETFFDTLHTWFPTIYDIKFVMRSCKVLKGGLQDVADDLGVVRIGPSHQAGSDSLLTASTFFKMREEYFNDTLDDPELSGKLYGLGQTFTLQNGVAETVRAGTAATIAEREDRAGPSLALAGREAHNQTPGPAGPPGHGVMGMGGALTTPVMAGAMPAQMPTTPYGPMANGPYMRTPIGVGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPL5</accession>
    <name>A0A2G8RPL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_14754</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPL5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPL5"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013573923" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="213"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL23443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="621" mass="64685" checksum="52D68102873F2C1F" modified="2018-01-31" version="1">MVAAGLLVLSSLFSLALAAPSLQQRRHVVRSVSVPHGFSYVQKANQEHTLTLRIALVQNNATGLEKALYDVSNPASENYGRHLTKAEVEALVAPAAESVEKVQAWLSKNNITTETISPSGDMLKIQVPVSQANALLSADYNEYTHDTTNQTRFRTLTYALPETVKDHVAFIYPTTQFIEPVQRNGPVFKVVDLPRVGKRTRSKRAVDSSCNTQITPACLQELYNIPTTAASASANSLGVSGFINEIPNKSDLSEFLSVLRPDATAGTFDIVAIDGGITNTNSQGTVEATLDVQYTVGVATNVPTTFVSVGNNNQDGDLGGFLDIINFLLKQDNPPLVLTTSFGFDETGFQSETDVANQLCTAYGQLGARGTSILFASGDGGVSGSQSSNACNGKAFVPTFPSGCPYLTSVGSTQGINEQAADFSAGGFSNIFAQPDYQKDAVATYLNTLGNTNKGLFNTAGRAYPDVSAQGVNFVVDVAGQGQGVSGTSASSPTFAAVVALLNDELLNQGKSPLGFLNPMLYSTGAAALNDITKGSNPGCGTQGFPAAEGWDAVTGLGTPDFTKLLAVVTGSAASSTGTNTTATATDAATTTAAADTTTAAATTTTAATTKTGKHNHHHNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ09</accession>
    <name>A0A2G8RQ09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ09"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="228" mass="25475" checksum="FCED18EFEA98542B" modified="2018-01-31" version="1">MNDIAGATALPLEELRRDEDFWLEDGSVVLVAKKTAFKVYKGLLSAHSPVFSDMFSSTTHADETYDGSPVVRLSDSPEDLKWVLTHVMPKTLRHLQGTYDFKSSELSALARLGHKYQIDLLERHAVDSLKAAFTNDFEQWEGRLRSPQVPSHSGYSRYNPIDIINIARLTNTPSMLPLAFCLCAQNRDIIVDGQARGDGTHLFLSKTDAKRCIVGLAELSWTLQQAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQB2</accession>
    <name>A0A2G8RQB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQB2"/>
    <dbReference type="OrthoDB" id="2741844at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="235"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="326" mass="37119" checksum="147960D5ECD16060" modified="2018-01-31" version="1">MWLLHTKTSELKFYKDSKRVRYAALSHVWEADDHRQPFREIQAIYSRCLASGEDPRELVTAKVRNFLDLAERDGYKWGWLDTACIDKTSSAELSEAINSMYRWYCDADVCYASLSDVADDDSPLLPESDFRSSRWHTRGWTLQELIAPHTVVFLSKSWDFIGTKASLAGVLEEITGVDLPLLASPIPPESSTISIARRMSRASRRETTRPEDRAYSLMGIFGVTMPIIYGEGGERSFERLQVEIIKMRPYDQTIFAWGPIHPNIDTALANLRCPRSLEYPVLCIPEDPCSRLLAPSPGEFSSSSNFEPIEPERRGFDCVTFPHTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQV7</accession>
    <name>A0A2G8RQV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_13640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQV7"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF15">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL23889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="525" mass="57202" checksum="9D87C93E6AD45077" modified="2018-01-31" version="1">MPIDRHSSSSGSSQSPRPEARRLFDDYDSLNDDSALENQKALTPAKPTPLPKAQLATLCVVRLVDPIVFTQIFPYVNEMMDHLHLTDDPSKIGFYSGLVESSFAVAQVVSIYQWARLSGMPVHRAKVSQNLTFTLDVIGRRPIVLVGIFGIGLATVFMGLSSTLGGVLFARSLGGLFSGNIAVIHSVLGEITDSTNQAIAFPLYGLCWPLGAIIGPLMGGLLSNPATKFAWLDIELFRWYPYLLPCLAAAAIAWAGCLYGYFYLGETLPSKRSKQKDDIQMAECHGGVFEKPSQPASIRYLLSIPLIRALCLSGAGLSFITTAFDVTFVLFCYTSVPQGGLAFNATQIGYALSISGFVSIFLQLFCMPYLLRRFDNARMYNFCMGLWPFCFVLLPGLNILARMGTADLATGELDPAAKTLVWMGIFVILTISRSAALAFSVSMILVKEAAPDPASLGVTNGITQFAMCLSRSFSPAFASSLLAFSIGYEFILLRYLWVMVMTTICFLGTTLSRRIAEGRRTPVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR12</accession>
    <name>A0A2G8RR12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR12"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="224" mass="24848" checksum="FCD5B0219455C7D2" modified="2018-01-31" version="1">MDFEDHTRDDVDDLASIVLPVLLDRVKADVDAIEERTRARPLPVNDLEKRLRELADRVCAHVILGGTPTELVRLVERLQGIIGQTPAALALGDCFRQTYNRTRNPIRYREAVTRRATADETRCRASTLEVAYERANTTFAETTLAFRIQRLVEAAQASYYSACSAADKYAAMGGEAGPNVADSLKGERREQEHADKQARIAREIQEASARSVEGDAESGEGRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR54</accession>
    <name>A0A2G8RR54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR54"/>
    <dbReference type="OrthoDB" id="3237202at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="171"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="508" mass="56474" checksum="56A27A16EC0C54B4" modified="2018-01-31" version="1">MPHINPTVHSLAGHPNSQWIQRSPGVPDKFSPEHVHSRDPVNISLVFAQPNSNSLVETQFLVCCRELQAKDEDGRSPTQEEAVPLDPRGVYGVTWPFDNDPLRPVAVFPGSRSKALSIHASLKGLLTQRGLLRPPPPTSTLTTLFSPSHFLSIAHLRPHSNAATMLDHRGFSAYITTNKLELVEFEPRVDQQTHTVTCWIEGPVGQPFVVHWRDHGSKVDSASWIYVDGFKVSGQFLYGRGHELRRGVRVGSEEERPFMFAQIHPADFHAHGAHGGNPADKNVGSIVLEIRLIKRVGEREPNPVRPPPSVVRGNRQPGEVAIRYGNAHPTAMQQRTYKIEPFDPKAPGPYVTFIFRYRSRDWLASQGIISHRDVTSRLLILPDVALCSKADLPPLEPEEDQAASPAVPSPASGRRVSSKSRAQPPAQASSSRLPPPPTPGPSVRLKDLGLGHRPQGIPETSRVSSATTSRSFSGTWDHRTPFNDPYEQWNEYEYRPEDLDDALNNYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRU6</accession>
    <name>A0A2G8RRU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13983</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRU6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRU6"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000020">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL24230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="155" mass="17103" checksum="E5F98C571540A4A4" modified="2018-01-31" version="1">MSLQALWRCADALRNPFRTAGLGSIRTATKRAGGTVSNHGGSPGKRLGVKKFSDEYVIPGNILVRQRGSVFHPGQHVKMGRDHTLYATVPGFVRFYKEPGTRKDRKYVGIVLERGEKLPRDETNRGRSRFFGLVDLTAFNKEPSATQETAAPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS22</accession>
    <name>A0A2G8RS22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_14068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS22"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS22"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="6">
        <location>
            <begin position="81"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="414" mass="45663" checksum="280ECA44CC146326" modified="2018-01-31" version="1">MLSPRQPTLRLLRTVPRLRHTSRRWASTEPPPAGGHSNVIGTSSLLKSTRDVALRTQGLKWVDLVDSDPSRDMVGRETRKMNMYQAVRDALSIALTKDDTAVIFGEDVAFGGVFRCTMGLAEEFGRERVFNTPLTEQGIAGFGIGYAAMGHTAIAEIQFADYIFPAFDQIVNEAAKYRFRSSGNFNAGKLTIRCPSMAVGHGGHYHSQSPEGYFMGAAGLKIVIPRSPIQAKGLLLSSIRESNPVIFMEPKILYRSAVEQVPIDDYEIPLGKAEVLRRGSDLTVVSWGTPIYSCESALDLLAKPPPSISQHVPESLRSAKVELIDLRTIMPWDVETVVESVQRTGRLVVVHEAGRIGGVGAEIGAEIQKKCFLKLNAPVKLVTGWDTPVPMQYEKFYMPDNIRIMDAIVETLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSL3</accession>
    <name>A0A2G8RSL3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSL3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSL3"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Berberine/berberine-like" evidence="2">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="207" mass="23064" checksum="85EC1E2FC336E52C" modified="2018-01-31" version="1">MTHRRRGGGDGQRHLGTPTSTSLQKQDWITSVLYLAGANTTAQLNTTLAADMHATFYATSTFVPESAPMNRNASDALFEYFYGPGANTNIAWYAIFDLFGGGDSVITRADKDTNAFDGRDALYSIQYFGMIPASVSDADGIAFVQGMKKAIESNQPETQFKEYVNYIDSTYTAAEAHKRYYPTHTDKLKTLKDKYDPKRVINFPQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RST7</accession>
    <name>A0A2G8RST7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RST7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RST7"/>
    <dbReference type="OrthoDB" id="2751552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="426"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="608"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1132" mass="125545" checksum="855FBEB2D9F97BD9" modified="2018-01-31" version="1">MPGPDAPDASAPSVEADGDEIDHTEAGTPPGTPPAIDHLPEPRTPDANHPTTGADPLPSGASPAPADGVQVPQITDHPSFVRHCPSSTNRDAYNKKSGRQLAPLLIDESGMGPRFHLLDNEIFSARITGKPPSEAARKKFKSPKLKKGMLERDIYPQLGAVIDSVLKAAKCKKLRFLDTANHKANDGNRGRTETFNDAGLYRTTEHARDATDLDPERLKKSKMSREQLEARLLGARSWFWMDVPVEVKGDEKNSAFYFKTKPKKGWKKHRHPAAAAAASSSEDERPEDAEDEEGSVQQEGEDEEVEEVGEAEGGGDVVVMEEEVADQGGDEVGEGENDEVDEDEDESEDEGEVDDDDDDDDEDEEDEDDENDEEGDEYGFDDLDYFEESGEDEDVDFEDEEEAPEDQENPTGIIKKSVPPFIKLSDNGEKALGQFVEYHLNLFKYQHRTFCYSIYICFDMARLLYFDRAGAYVSEPFSWVEPTSLLHEFVWKFAKLANANKLGDMGHDTTAKMVPLPTRRRFIREAKNPDLAPHVRSGLLKAADSDCPLYKLTVKDVPPSRDEWFPDEPFPEPPPPPPSEPKSISKKSSSSGSAKKSAKAKDSTPPPRKFIVGRPHFSADALVGRCTKGYMAFDVTNPKKWVPCFLKDSWRPCVRGRTRPEHLVYERLKRKGVKPTDGIATLICGGDVGGSRAQLTRVQEDLPDHNKPVLRVHYRLVIEDIGLPLHKFHDFGDLSGIFVDVLRAHYKILKRAKVLHRDVSVGNIMIRVDEDGGTHGFLIDWDLSRLESELGNGPVEPDRTGTWQFRSALSLHYPRKPYRRSDDFESFIHVYLYLVLRYHETLVSSVKDSVMQLFEQVSLVGGVKVGGDAKLNMIDSAKPPFKVASNPPLQDLVIKLVRGCSFAYSQLDLDAMDRVYGPDRTLAPRSPNPSSSSDTGSSPPRPGAVFRARARRMDSDDEMSEASDDDEVEKALGDGDEDDSTHRSAQRDLCTLGTFLTNPRNMTNLFAKHSQAAMGADDKGRDQFAARRHQDVLVPLHMGSRGIATLSVSASVPSEEGLPAEGLPEHDMFGTAWKPSDDVPPPSSSPTRSFGPNKRVRPGPSSDAEDDSVDTEEERRRAKRAKGKGRARGMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RSX3</accession>
    <name>A0A2G8RSX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_12499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RSX3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RSX3"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="134"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="394"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="65691" checksum="C282115A113AA2E5" modified="2018-01-31" version="1">MTPPPPPHTFVDVLIIGAGPAGLMCANALVHAGVKSYGLAERLQREGARFDRAAFYNPGPDGGITRTERTQVIFAPTARYPYLVTRHQAGIESLFHDSIATKGLVVQRPVVPTSIELSEAGSDLENPNAYPVKVTLKRLDSTDNEGEEVVHAKFVLGSDGAHSWVRKALDIVMDGDQTDSIWGVVDIVPDSDFPDLRNWSFIHSNKGTLMNIPREGDMVRFYIQLPDDTDFVNRETGRVDMAKASPERIMETAAKIFQPFRVAQVGEAEWWTVYIIGQRVARTYSVQDRVFIAGDACHTHSPKAGQGMNASMNDTHNLAWKLAYVLRGWAGMSLLKTYESERLKYAQELINFDKKWSKLFRDKPQSEANADGVSHEEFLGMLATSNGFMSGIGIHYEPSVIVDPRHQSYASKVVVGQRMIPYDFIGAADAVPVNIHDMLPSDTRFKILVFTGDISEEGTMNRVRALAERMVAPTGFLKRFGKGAYEDMFDVLCICATKQDKMDFTDVPILFRSHWSKVLLDDKDMMGRCGGGGYEAYGINPAEGAIVVVRPDGFVGTVAPFEHLDDITRYFASFLLDRSSVSEGMRRLCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RT37</accession>
    <name>A0A2G8RT37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RT37"/>
    <dbReference type="STRING" id="1077348.A0A2G8RT37"/>
    <dbReference type="OrthoDB" id="429967at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="191" mass="20612" checksum="EAF352106A456C83" modified="2018-01-31" version="1">MLYIFGEEDAEVCELSACTVVDSDSQSETSSSADEHHSRASSANPPSRWATYPDTYFLWSRLPVWTGRVLPTIGGEASRPRASVSGTYTAKRGALWQSIPSSLPHQLATGAFIPPWRALGGFSEAWLSMHPVSSSLLPPPPPMTTPPPLPEVGAPPWPSRSPLSVSHGREDGSESSDMEEESDTDDMDLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUB2</accession>
    <name>A0A2G8RUB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_12995</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RUB2"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF24">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="10">
        <location>
            <begin position="109"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="424"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="349"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1150"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1229"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1182"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1192"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1246"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1284"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1303"/>
            <end position="1313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL25106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1313" mass="146453" checksum="FB89AAC73B7DA01C" modified="2018-01-31" version="1">MTKFPPTTTTNAMLTPPSPSSSPSLIPHDPTNSRKRQRSLSMESEASTSSPKRSASQDPQTLQSNDMTTAPPPILDTTTPDNDIDAYMAEQGEDTGVPLQQVSTPSAGLTSAQKLQRVEDALQGTMVKGETWYVVSRRWYSRWKKAMTGEEDKEGRLEEQDVGPVDNSDLCSQSGEVTSQLLEHIDCEFVPESTWKLFEEWYGPSRLPLPRKVIERGFLHQASLELRPPKFSVHLLVLSSIPGQSIAPLEVTVSSTDKVADARRAFAEAAAPQTASTTQYRVWRIPSQAASAERLFPAETLRTCGATELTPAEATVEDEFVDSGEAFVVEFMARGEWLVDASEFAVTINGSTSQNAPPPPPPPPLTQPAPLFSTGTDFFSQLQQKSPPAVNTTAVSPFKPTALVSTNKPSTSTRPKLRQDPGTMGLGNMGNTCFMNSALQCLVHTPELMDYFLTGVFQEELNPDNPLGMHGAIAQAFGALLSRIWDNESAMSSYTPREFKQTLQRFAPQFSGYQQHDSQELVAFLLDGLHEDLNRVLKKPYVEKPDWEGGGDKELVDLANVSWEGYMKRNDSVVVDLFQGQYQSTLVCPECSKVSITFDPFMYLTLPLPVQKKWYHDIFYVPWDLEQPHVRVPIEVNRDSSFKEVRQLLGRWMNSNPENLLTLEIFHHKFYKNLDDSVGCDDMADSDTIICFELPCNAQQSRNYRPQPDDPLILPVFASETSPSRAGGYNSGPALFGHPFVAVITQEQAKDPDAMYDAVADRLQRWTKHARDLFTWEYGSRSDDMEPVHIPISGGPVRDSVTEIKENGDIITVEESIPEEGDIVDEKSTIVQQADEDEEMNPVSAVPRKVGFKRDLFRLRVQKCGQPYGAGHSFGGNLSRFDTWEQRVASSKDGVLIRPLDAFFLEFDSHMKGYYFGDEKNHYEYALWTRFDEFIHPELAASRKAASAQKQKGITLQDCLDEFTKEEKLGEDDLWYCPRCKKHQQATKRFDLWKVPDVLVVHLKRFSNSRMLRDKIDTFVEFPLDGLDLTSMVGERSVGKRLQEAGVNVESLGLNDLEEPLVYDLFAVDEHLGGLGGGHYRAYAFNHVTGKWYHFDDSYVMEAKADQAVNSNAYLLFYRRRTSRPIGGKSHEKIEAARVKPIAHVDPVLTQDHQLPTPPSDGSGSRGDPSVGSIPATVLEWPTPNSIVPSSPSSPPPPLENLPPTFDEALYDEVVQPSLDGIHMLSSSQLEFPDPSQEGSPSSVDAEPDLEDNDDSSFYHANDDDPLQDYPEESVRLRKATFGDSDDEGMDDVTDVVMTPGESELDENDSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUP9</accession>
    <name>A0A2G8RUP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUP9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="516" mass="56097" checksum="BD85D40F2449A7B2" modified="2018-01-31" version="1">MVNNVKLPAKLRGCPPHMFANWSQHAEPPNDVPVAPPNLLVWRHYEPQRATDAVGQPSTVQAAAGAPVAVPSDPEPREDDETQFQGGSSANPIPPSHEQRAEGVELSQNPPLDFYVNGAPITPTDDASLWLSPNLPPAAIPYSSHAPLTPLDALHSSRYRPDCPPRPGPRHASHQATQWAETHASTSRVHGADAAHYPSHSDVLPQGSAHDSDPQVHPTSPSDLYSRLSVDAATGAYCWVGTMNLATLDDPAVRTEPSRHVPLLEHLPQPGQFPPFGYRPPLPQDASFHRRTEPSRFAADVPLSDYLPHQPGQFPPLGYPDVVPQNMLIFGQNDAVGPSQLYSQEDEDVSMDDQQDPYREENAYFHGGVPDIPLPDHLSHQHAQIPPFGYPNVVPILSHPNVLPRDIPVLGQNDAVGHSRPYPPEDVAMDDQEDLHHEGDGYPYWGISASGSQEGRNTNLPNGPVAGPSTNHHEPLAADPGLLNAPWHAEFPPPGGWPLPPQDENPQPPSGYQGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW14</accession>
    <name>A0A2G8RW14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW14"/>
    <dbReference type="OrthoDB" id="3239894at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="911"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="935"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1059" mass="117637" checksum="22F4AFCC10CDEEDD" modified="2018-01-31" version="1">MPKVPRLRHSALPRAPPRPSDLAVRHVHEPRTPQDYFVRDVLALPGQDRGHPFECRVGLHLFVEKTTHPVEGIFQDPDTRKLFLCIYPPIPSRPLAVHLDTFDGNDIDAPGAPLWASHVEASRESPLQIFCLAEGLRERAWRLSGQVPSGQSALVLLRLAMVRYLDSFLCFARYTVPATSREVSSRFTAIEKVSDVAPPPRPGLEPRTNTNSIPETCQGLGILEGNSADTEVTQNKDGDGRATTNRSPIQSLIQGATMLENQGNSLFTRIALAPAAAYRMAQSPTSSEISASFVIPSALSSLFTPSAPPTLPAFERPEVISDQTTFEDMSGSEDEDAVCDNSDWEDIGDEDLCGELSDSHLPNGFPSAPPLPTSTPTLSSTSPSSDSIPSPPPQDIDEYYTHPEFDGEQPLAALRLWHPAIVLAALLVAWLHLSGHLPFRYCDTALTVIGYMLMLLGHKDLLAVLPGSLSGCFSALRVEPRFQIHPVCPACHRVFPLAVYANRLAHCDRAPCKHALFRWEDLPGRSSQARPGSAKPVLQFPYKSIAEQLASILGMPGVEDAVDAWRKRHRVSGVLRDIFDGRICRQLLGPDGLSFFRYDLHDTGPDGELRLGVTLGVDWFSYIRSKLSPSHSSCPMSLSIVNLPFYLRYRTAYLLLAGIMPGPKEADPEQVQRYMRVLVNELLRLWFYGAVIPTPKNPKGRRVRVILVGVVCDKPAAHKLGGFGSHSHSFFCTRDWISQAFKATIEAFKKHAFRSRTDSQHRVYMAQYTQCSTKADKEDFVRTYATRWSELSRLPYFDMCRMIVIDPMHNLFLGLVKSHFYHIWVQLKFFRKSRELRCLHEILEQVELPAKLGRLPKLIGEPAGGSLTADQWLILGTIVGPIVLPDLWRRFLDGLDGPDLQERLGTVASAAAARREKRAAKRTAGHESRAVGKQNGKRSGARRRKKVIEDVAAAPRRSGRVLKPTEKRQGMVLEPDDSGALEIEDEDSWSQDSENDDGEDGDGNLPTSKLHPRDLDNFLKLAEALSLYLADELTEESAAKADSLLREYCTELLEASVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWB2</accession>
    <name>A0A2G8RWB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11557</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWB2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWB2"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013909932" description="Cupin type-1 domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="128"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="323"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL25805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="478" mass="52351" checksum="1E87C9C8BE81CF09" modified="2018-01-31" version="1">MFTGLSRLLLAALALSSVVSASPSDDEQVKSFLAREGAAVRSLNLGRRSAATTPTRHLRPEFYEDDVSMRRRDITPPDVGQVADFGGNDPQPIRNGAGDTFLSASNHEIDAQNPDNVAAPTTDQGTVPNLKWSMSLSHTRLLKGGWVREQTITDLPPSKDLAAAELRLSPNAYRELHWHRIAEWGYILNGTGRIAAIDDNGRNFISDVHGPLNGTDPDIYYFPPGVPHSIQALDQGLEILLIFSDGNFDATGTTFMLSDWLARTPLDVVAQNFGVNVSVLSGIPQKDPYVYNSNPDTPPPPYGHADEQAIDDPNGKVPSPFVFHLSDQEKKTAPGGGGWVKIQDSVTNFPVSTLLASALVFVEPNGLRELHWHTNDEWLYIISGHARATAFAGSSSSRTFDFQPGDTAVFPVSYGHYVKNLSPTEPLIYLELFRAPKFVDFSATQWLALMPTRVVADLLNMSTSVVETFKKEKQLIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWL2</accession>
    <name>A0A2G8RWL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lon protease homolog</fullName>
            <ecNumber evidence="10">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_11659</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="10"/>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWL2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWL2"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000091">
        <property type="entry name" value="Lon protease homolog 2, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="ATP DEPENDENT LON PROTEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="12">
        <location>
            <begin position="766"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL25906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="972" mass="105883" checksum="7D797C29603D243E" modified="2018-01-31" version="1">MPTLATLPVLTLPHPLVLLPTARVQLPLHDATGSRLIELVQRSETQLVIATVPCSSSSTLHPWGTTARVVRIVRPLSKSPQRLYHVTLQGLSRIYFPDTKSDAPFAPSDLIQLKAEYPKADDAPSPETVAPFRAAATKLLESLAQNATQQSRKDAYAKISQMMEEVSDDRTPWMADVIVAGINKVEYDDKLDFLSAAGSDDRLRRATELFVKQASISEVTKKIAQSIDESLSKQQKEFFLRQQLAAIQRELSNLNRAPSGGSGPEVPNGFPKPGSELDDNEQSEAEDMAEIRSKIEAMAKDSEERKMAVREWKRLQRIPSGSVEHGVIRSYLEWVTSIPWPSSAAFANATSSDKLRDRGFLADARKQLDVDHYGLEKIKRRLIEYLAVVRLKQLQAEAPLVADLPPLLPASPSVNGEGGSGDAAASAGQRSEGDATARALALISKALKLGTSAEPKAKPDAAVPSSQSQLALVPKRSGSGKAKRGAGSKAVKGPILLFVGPPGTGKTSLGQSIARALDRPFQRISLGGVRDEAEIRGHRRTYVASGPGSIVQALRKAGRPDPVILLDEVDKIGQSNFHGDPAAALLEVLDPEQNHSFNDHYINVPIDLSQVLFICTSNSLETMSAPLLDRCEIVQLSGYTYDEKMHIARKFLLPKQLKANGLTAEHVTLTQPTLLHIATHYTREAGVRSLERAIGAVVRYKAVEWAEYADGAGIQNANQLPAIEVQQSEAEKAKTKGRTYKKVVEEHELEKILGIARWDEEELHREERRGLVYGLVVTGMGEGGLLPIETTVVPGSGQLKLTGSLGDVIKESGELALSWVKSHAYDLYITKLRAQDPLKHPDPIDIHLHLPSGAVKKDGPSAGIAMTCAFVSLLTGACVPTNIAMTGEVTLRGRVGPVGGIKEKVLGAHRAQITKVILPWANRKDVEHDVPLEVRADLQFVFVRTMEEVLEAAFGKGVLNWRRNVLVMESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX95</accession>
    <name>A0A2G8RX95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_11894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX95"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL26139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="525" mass="56474" checksum="90C2F04031B4BD56" modified="2018-01-31" version="1">MPKPSLSLEGTDGSILMEMSPEKGAPVDESTESEAIAGPQEYRLYKRRWIGLVALVILNIVSGMTLVWFGPIANAVVPELGFTLDQINWFGNIANVVYLPSAFVMPYLYRRLGVRKACFIAGSLFVVSAWVRFAGTVHGLSVQGSYALIMVGQLLAAMAMPILQVVVPSYSERWFNLKSRTTATMIMSLANPVGNALGQLISPLVSTTRDSILVMAIIFTAAAPIVFLVGEAPPTPPTFAATHKRPSLSSLGRAMLGKVPRSEYAYMTLRQRIDFVILCVLFGVLSGIINTFAILTAQQLAPYGYSDNTAGFMGAVLLLVGLVCGAISSLLLDHVFTNHLALTGKLLLPAMGASWLAMIWEIKPHNDVVLFVLAAIIGGTGLTLLPVVLELGVELTRNADGSSAILWFSTNLCGLIFVLVEGALRAGPNANPPYNMHRAIIFQGVLGMAVVVLVYLLEGKQTRRAQDEVRDEAARTHDQSTGPGVDVLEVPLSPSMEERDKPAPAEITRVDLESGKDSPVGMVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXC7</accession>
    <name>A0A2G8RXC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXC7"/>
    <dbReference type="OrthoDB" id="2753061at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41101" checksum="5DFC89A2BCDD375E" modified="2018-01-31" version="1">MPPASQDDGGQSAGRSSFVRRVRTNPAWSSGLPEDVWYLVAGQLRPHDLAQFAAICRDTRYIADRFLHRSPTIRTARGVVSWAGALAARQKRRPLVRSLTIGWDGADTVEGDADKAYGEITRMLRGSHHLRSMTLFADGPEGRFATKRSLPHGVHTLNASAATFLNLHMPLPPLLHLSVNLHVRDLKRTLGAICSFGETLLQLRLFVKWETPFVKTKDNPARWCVLKTPRLVYFELREERSEKNVPLRITSGRWDKLSVTSNWPVVLAERVPSLRYLVWQPLWGERENDVLPGGAFYDVVREYRNNLFALLKLDVLAFTLADGRYSCHEAGKEDPRDGRPVAGPEDLWKSMEKPEGHREVQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXG6</accession>
    <name>A0A2G8RXG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_11939</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXG6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXG6"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000636">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="89"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="9">
        <location>
            <begin position="1084"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="579"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="670"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="711"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="728"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1032"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1068"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL26184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1136" mass="123550" checksum="A34094AF3F3A259B" modified="2018-01-31" version="1">MDPFSSLQVPDGSQPGPSRQHGARPVSVQPASSMANSQSASRKRASHNVVTSQPQQDEQPGYRDIYSHPAALEYAAAHPRRTIPKFGPYLLLQTLGEGEFGKVKLGLHMQWGEEVAVKLIRRGNIDSTVRMSKVEREIEVLRTLKHPNIVRLYDVIETDKYIGIILEYASGGELFDHILAHRYLREKDACKLFSQLISGVWYIHQKKIVHRDLKLENLLLDRHRNVIITDFGFANRFEHRSDDLMQTSCGSPCYAAPELVISDGLYVGSAVDIWSCGVILYAMLAGYLPFDDDPANPDGDNINLLYKYIVNTPLSFPDYISEEARDLLSIMLVPDPARRADLPTIMGHRWLAPYAHLFQKSVNELERTAIEQHHQKRLAYQRQMKAVANGESPSSQKMARSQSARVEGYGSSPPSSGSRNHRDQRYPAQPPQPEFLYETSAPSSSGRRGVNSAIVLPTSSPIGLEDDPFAPSPSQEVPSIALPSAHVPQDVTNGIHEDDRMQVDGGSTLPQPVAYAPVKTTSPESKRSKVPNRHTIQVEYGESESRPEPLKERGRTNGTSGTPERASKKRSIDIDPRSSQKPLPGTPSRTQPGSTIPSPSAVTPVVSIEVTAPPVTPVTAVDEKLPHPPVHSQNGSSASSTGSASSKGRHRKGLSIDKIGISKMFGSSFGPEQTNGHVARTPSQSQKPVPDAVPASLKDIVRRPSSVQVGTSTTTSTDTSADASLLSPTGTVNSKKSSRRNTLTVMVAPIRSSIKPRSKKTVETPMKEKADDKGPLSSDAPALPPKGEMLPPSTPQPLRPGQDEASGYNSNTWKSQRAPVPASTVKASKVMQWFRSKSKGRGPADISDVEAEKPVTDAPPTAIIPTPRQAPFAPPINTHLLPTPSEKIHSPIPLTATPSDQSFGHHGITERWLKGISGGRVNLRVHHGAVDQTTITTGSPPEVMKHVKAVLEGMGIDIAIEHEYKYRCIRPKKKRAGLGLRDGSGSLAAFTIVGSAASNGVDKRGLPIPSQMQSPSFGSTTGGMLRGLLMRRQSSQVSSGPVHQVSPSLESEVGSDSVLASAVPGSANDPTSPISLDTIYGDQQQDAGDEVRFSVELTRLDRLDDTYSLDIRRLKGNLRSYKFLYDTLRQRADLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXP2</accession>
    <name>A0A2G8RXP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXP2"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="47"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="257"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="875" mass="96189" checksum="343690668FBA0FEA" modified="2018-01-31" version="1">MDPTLSTTLPPSNSTATNRAVSVTRKSLTDRAELHYFHGPENVPGGYAILSHVWEGQEQTFKEIQDLRAECAKSGQNPRDLASPKVRACCTIAARHGYRWIWNDTCCINKESSAELSEAINSMFRYYSLATICYAYLYDVPRASRSALEDADSPFRKSRWHTRGWTLQELIAPRLIVFLSDDWEMLGTKMELAELLEEITNVPVAVLRLAQAVHDFSVACRMSWASNRETTRSEDMAYCLLGIFSINMPTLYGEGERAFLRLQEEIMKQSFDASLFVWEDPGSMDQNVFVRREIHAKLPDDTCYHTLSDRYFLLAKSPKSFFRSKAVSFSPALIDGVGQALDTNTPSFSVTPYGIRAQIPVIDGPNFSVAMLCCMDGTKQTIGLVLTACQSPPDPSRDLYHTAWNQRVWRTVLLGEDFANPRLFGEPVSPEWRDIYIADRPPPAPASILSTPSDYTLSPPFRFPMQELEKCLGTYGALVHVSQRQFGWAGSPPVVFTFEHKFVFATIYVAFGRCSSGSSRSLGRGPLWASVLFDTGTRHVKPSADGVVPRHDCGEHHIANWPDSSRMFTGKCKNGDILLTLSFGEDALSPTETFVPHIKHHVEVRSMIGPGVVSWKSDSDHAARPGATVFAVVRNPAGSTHLNAAVKDLQNVHVVKADVVDHASLKDAAKLVSGITGGKLDVLIHVAAKMDIPGVMRGFDDFPNMAELDAEFIDAYKVNALGPVHSITAFLPLLRASSTKKIVVISSGGADPNFVRAVEVATMSAYGMTKAAALMATTKFALKLKDEGFIVCSLSPGLVDVSGTIGESGSPELRAATAPIADMWTQKYGISVTFQSPQESVSMQLKVIDELKPSDNGLFLSHEGGEWVVPLINNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RY88</accession>
    <name>A0A2G8RY88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RY88"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="289" mass="30934" checksum="9038EF5770A4AAA9" modified="2018-01-31" version="1">MPSYAVVGASRGIGLEFVYQLACRSDTVVFAIARNPEGSTHLKTAVATFKNVHIISGDVADHSTLEASLRLSKQVSEITSGKLDYLIHNAANLDPNDVFKGFSDYPNMEDLDNDFISAVCGPASRHANQLKLISRPFPLQYKVNSLGPVHSITAFLPLLRASTTRKIIVIGSGGGYAKTILALGIVNICAYAMSKAAAHIAATKFALQLKDEGFVVVTLDPGFVNVSATAPSKDALKGFRAAMRETEVQFAVQTPKESVLDQLRVIDGLESSHNGLYLSHKGGEYQAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ37</accession>
    <name>A0A2G8RZ37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ37"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="317" mass="33695" checksum="C91AE3EB0F7E3C14" modified="2018-01-31" version="1">MSISTDAAETLVLPRTTPSQSPTRNTNTSTATWFPARPPTGYESLPGCEDPETRNHSDVDVELGAPKPTSSAGVRVESEDGPVPPGPAYRGRAQVHYILAQAWTRTSQWTRTHTPAPGVLKMLAILLTGGLPATLAFSSFAWLCGSEILVSLEVPPYASADSGAAFRASMAGAPVVALAIGALACVDFVACRLPRLRARRAARERAQESQSRGRGRGRGRGRGRRRRDTGDTGDGNGDGNRDGEYDQTTDIVALSLVCALASVLAMPLGILMMPHLATETFGAWNALGWSATGLGVPFLVVFVPLSVLWLWCTTVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZQ1</accession>
    <name>A0A2G8RZQ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_10105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZQ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZQ1"/>
    <dbReference type="OrthoDB" id="3238562at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24829" checksum="5742A3CB2907A04E" modified="2018-01-31" version="1">MAPQLKYELRKRDVRVHTESLRCIAICPDGQYLAMGADDGRLFVSTMKDGVLRVMLLTHAPVVSISWIATPVRSLELTFACSNGVIADMTMSSEITQATYFRAPGHQIEHIALTASGSQMASGAGNDVRVWRKLNGAGRWSHHRSLHLKETSTHSRPIWASTMHWYSPGDGTEHLIVAYKHHAICIWDVDYASVIRTIGPPELLPRYKLFSMEPMFHMASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S003</accession>
    <name>A0A2G8S003_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10236</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S003"/>
    <dbReference type="STRING" id="1077348.A0A2G8S003"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="473"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="592" mass="65112" checksum="A7EC862106B5A5A8" modified="2018-01-31" version="1">MAHAGSIPTIYGDGGPLVHIPDDVTIPQFLFDQHHPLGGEALHSRSPTYFVDDATGRQINGEEIRARVFGLANALHIRWAIGNGDVVCIFGPNSVDYPTVIWATHRLGGIFTGANPAYTVDELVYQIQTSKATVLFIHPDCLKVGLEAARKAGIRDDRIALFDAVPGNPHVTIGELVKEGLTQPRRYVEPQLRPGEGKTKVALLLFSSGTTGRPKAVMIPHFAVIANCIQMKQCTDMRDADMPNDQKLYSVGDVGLGVLPFYHIYGFVVSLHFFLFCGMSLVIVSKFNFENMLKSIQRYKITHLTLVPPMVVLLCKHPAVKNYDLGSVKLMACGAAPVSAEITRQVAQVLKNSWIAQGYGMTEIGSISRFFPEADNRVGTMGSAGRLIPGAACRILKADGTWGGYNETGHLIITAPSIAIGYLDNPEATAETFKDGWIYTGDEGYVNEKKEIFILDRIKELIKVRGFQVAPAELEGHLLDHADIADVCVVGAPDDFSGELPFAFVVLHDNVRQRVSKSPVDEERLRQDILKHVSDHKTQYKWLAGVEFVDAVPKNASGKLLRRFARDRLKEGLKDGRIKLVQPGTKKVRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0J6</accession>
    <name>A0A2G8S0J6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_10414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0J6"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0J6"/>
    <dbReference type="OrthoDB" id="5592585at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL27267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="808" mass="91390" checksum="18D56B50845C2212" modified="2018-01-31" version="1">MPPRSFLETFLRRNEMGVRGMRTATDAFCDIPEDPTSEEAIYKPLIEALNLKDRCPGYAFRDTSLKADSQEGKLGSSKPDITCYATRDIPAIDQWKMALKDTPKNNKYKDPLYARADMGLAAVFIEVKQDNKQDCFRDPLPSSNGDKRATWEFVLPSDQLYPDEATQALGQNVAYATEVLRRQHRHCCYSVFLFGCWARLARWDRAGAIVTETFNLHCEPELLCEFFWLFARLSEAQRGYDLTVLSATSLDEMRFRHLIQAHAAVQRNKRKEVSEALEEHYLPNHVVSMWIPSATSHDGIVSDRQLLVSRPLLTPLTFVGRSTRLYWAVDCSTDPGRIVLLKDTWRSPSQDTNEGTIIETLHSTGRVVNIPGIVCHGDVCWTEIEDGSTNGLVVNVHDNEYQMTQTQIFLNASWVCGNREHLGQRIFERRHYRLVLNTAGYNLLDLEGTWELLHGVYDAFEGHVHRGIDPWSVILYREPSRPGRRGYLINWDFSASISENYSGDLLPPPSSQSWQFQSEERLTGNSSHEIGDDMESMLWLLLYCGLLRLPHNIGAPQLKRYMDDLFDQRSLPVGEGGLGALGGYGKVQDLEKRTYLDTIQWQNAIFQEWLHILYDCRSPRAGKAGHHALQGRWEPSELIRLWQKMLGLLGPPTDDVVVNLDPTKLSGHLARSVPRSVVTKQSQMATSVSSRYHVGSPAALKHVSSIKQSIKVSQHRKTMRLARTAAVSGPYPLGTQMRTDTYLAVGMQEIGMSNGPETASTSSHNEDATPKDVNTPSRFFTRGNRRTTERLSHKRQASAPEGGARRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S1P8</accession>
    <name>A0A2G8S1P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S1P8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="59" mass="6323" checksum="E97B439A0B011E6B" modified="2018-01-31" version="1">MSQQSQQQQHRQTNAATQLPASPSRSAVCEPLCCSANADPFAMRAQCGNTACQDGRRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2C6</accession>
    <name>A0A2G8S2C6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2C6"/>
    <dbReference type="OrthoDB" id="2762016at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="573" mass="64676" checksum="705887F05DC2BFAB" modified="2018-01-31" version="1">MTRSFLSRRRSVRTDASASLESDIVATLSPSNTLPHGSSIPDLDEDVMETICAFTEDIHDLLSVSLACSTMWRIAIRQLLRTQTIRLNSRKVICGFREFILNQKPTRAQHIRSLAILHDAWSPGHRLFHLNDMGDQLMDILDCAVNLDTLDLSLDNFEFNRADRYARLSSAIASMRALRHLSLSDPYLLGTIIVLNALSSPPVTICIRSTTIFPVPFLIPPPSPLKIATALDRFQSTPSVLTSLHFDFISLNEDTFALPQIRSVRSVFVSEVRGGPRLDVLLHLFPNLDGTLRLRLTPQERFRLFDNELRLAQIRDDNRRTQEVHHWARLDMLDCEAMTAFAFALQCPVRRLTISRFDSRVLADMRPQHLVVTSIRLPQDLTLINDCTRTPSLCAGSQASHVVLVLAHEAQDHRAENVDFMPRRSENVVFKSAVQALAFFPHVTHARLVFECYKDHPFRDELDEYDLVHQMRECASISPDGRILAACPSLRCLVVTAAGRDESQAGIPSHGGWFATRAWRVVEGNDRQRTTGRAEPASRRLEELSDYAARSIIEAEDLGLPDELEQNLASYGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2C9</accession>
    <name>A0A2G8S2C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2C9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="73" mass="8011" checksum="46B934BE9FBF1414" modified="2018-01-31" version="1">MDTQSVRRGACKALRPTSDSDVRADKPAKTEAILAGCARNLSVKDRLRLSSFTVQPNMSMTQAKSSEKRVDPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2H2</accession>
    <name>A0A2G8S2H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_09909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000031">
        <property type="protein sequence ID" value="PIL27965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2H2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S2H2"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL27965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="513" mass="57224" checksum="594625EEF8BB4F92" modified="2018-01-31" version="1">MDDYKSLAFALLAAGIATYAVRWYTDPLRAIPTVGGSSLPGLSWLAALRMLRNGKAVVEEGYRKYPERTFKLPALDRWLVVVSGRELVEELRKRGEEELSAPESLKEISQAKYIFDPLIVTDQYHVKVLQEKLTRRLPELLLDIVDEVMAAVQDHIVSREDEWTSVEVIPVMQNIIARASNRAFVGLPLCRNEEYLRLAVGIVVDTVKTMIVLSLVPRFLKSTVARFYNKVQRNTELAVQHFRPIIEERQRIAAQRGERWDNKPNDLLQFILDKAKSNNDTISTIAQRVLGLNFAAIHTTSTVTHMLTRLAEHPELLAPLRDEIEESIAAEGGWTSVALANMWMLDSLLRETLRFHGIGLLGMGRKAMKDLTLCDGTFLPRGTIVHTAAHALHHDSAVLERADTFDAFRYARMRAAAVRSGSDQGTGAKLQFAATTTSPEYLPFGHGAHACPGRYFADNVLKAVLAHLILKYDMKLGGDGVRPADVFIAMGVLPAPQSRVLFRPRKCGGDPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3Q9</accession>
    <name>A0A2G8S3Q9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3Q9"/>
    <dbReference type="OrthoDB" id="2746456at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="129"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="403" mass="45616" checksum="5F51E37FA8DD9721" modified="2018-01-31" version="1">MDPPVPPDPADPADVYPTVPLFSYDEGKQIYFQAHLLFSLNSLNPTERRLKFQLCSRLALPTYLPKPPQVLSDPFYTSYKWLTYLSRLQPRDSDADQNDSAPKRAKPAPGRSASPLGRDDDDTFWYHDGNIVVCVPGENTLFKLHRSRLESQCGYFKYMFDTRLVTMAGFFQGCPMYDTPRGVTAKAFKALLKAIETPLSALESPPSQSHTVSLLETAHTLFCNAVARLATNRLLELWDSSHVPTKACPGPYDDRSRSYTTTITTIRLAREYEIPGVLKRALNLLRAPLQRGLLGGVPRHDQAERQGQGAARGVPDAGAVRRLSGEWCCYGYSERGPNWRSAIVERGDLKCGAMDPLRHNLVEKRRAYLKDERWCEGCLRNKEDAWEAKRTERWGMLDQLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S487</accession>
    <name>A0A2G8S487_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S487"/>
    <dbReference type="STRING" id="1077348.A0A2G8S487"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="122"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="385" mass="42559" checksum="C6DCCD54E809B7D0" modified="2018-01-31" version="1">MGKERFRTGLTAIVRVKWLSRTAGFAHGSVESIIQKACKHFRLGAIQSDLVLLGELDGEQLEVTDDLLGLLPKGMTLTLSRVQQEDAPHVQASIDHACSDDELGNRTCSSGGPSRVPRAPGMFVFIAPLVGTKFTLECEHLDTIDYIKDQIAERTGMSPTRQRLLFRGRQLEEGRTLSDYDIQKENTLHLAARQVGGKPVIHLFPPTPNSRRDASKQVEDGQQRVTWSVAAHPDGTLVEKGSGLELSYLFWEAESNASLPRSPPLNPLLPYLDGTLKLLSLHTSARNDFITYWLPKLAKKPFVALRFLPQAAYEGAAKLGVEPAPDVVTRVFMRGISADDAEGPAWSAARARVREVDWVKVVGVEDGAWDESRFRVLEWGGMEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4Q5</accession>
    <name>A0A2G8S4Q5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4Q5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4Q5"/>
    <dbReference type="OrthoDB" id="5964929at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20673" checksum="80ECB8587A8688C3" modified="2018-01-31" version="1">MATTTTQILFNSPALHSLKRDQLVKLCKIHSIKANGKNSELIERLKQRALELPPEAQQPPSDEDEDDRMDEDADAPDIPGGMPMDADPAPPAASDDDCDMQGVVLTSRFSIPRPSEQWEVVMEDIAEVDETMGTASSKNSLKTVSNGEFGTHTSKCWSTVALYVPVFTLWSDGTMRGGLLSDRQSPPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S561</accession>
    <name>A0A2G8S561_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S561"/>
    <dbReference type="OrthoDB" id="2762167at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="136" mass="15072" checksum="6CC6D138B29998D0" modified="2018-01-31" version="1">MKMSSENVTIVSPQPLEIIRPQFNFKFIDTAYNLTANSNLSDFGPLSLTLRNKTFEGALFPSKIQFISDSEPPTAEAQVLIFTHPGFAEGTYNLSINEFILDGASKMPSGVTHFDVPVIFSFDPKGSKEEPTHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S5T0</accession>
    <name>A0A2G8S5T0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S5T0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S5T0"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013708293" description="Acid phosphatase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="50525" checksum="F40A53CC007DE602" modified="2018-01-31" version="1">MHPSLLLVGAMLAFATSAFAAVAQSFQPPASSPTDPSGNYTGQSNGTISNGPLVSGKAFDRFIQIWIENTDYATAASSPVFQNLSKEGLLLDSFYGVTHPSEPNYIAAVGGDFFGAASDNFFHIPQNISTVVDLLEEKNISWASYQENMPYDGFTGFNYTQKNYLTGNGTYTYYVRKHNGLIIFDSVANVSSRALRTRNFNDFAADFKADAIPQWNFVTPNLVNDGHDTTIDFVGDWLNYWLIPLLGDDKFNNNRTLILLTFDESETYTINNRIYTLVLGGGLPADLKGTTDSTFYTHYTALSTVQANWGLKSLGRGDANATLNNVIDFVAKQTSWTNNGIAGNDSSIPLLNITGTIPGPLNTVLYVPFTAPNTSAVGTGGGGVFVSPLLDKNFTAASAPKPVNLTASGLPNPWSTDPGFNYANGTEVIQAPSATSTKPASGKNAGARAAVGMREGAVVTVLVGFVLGVVMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S651</accession>
    <name>A0A2G8S651_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_09266</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S651"/>
    <dbReference type="STRING" id="1077348.A0A2G8S651"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="43"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL29217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="231" mass="24352" checksum="010F4740BCE18462" modified="2018-01-31" version="1">MTVRPPRSKFVSAVEKRLGRSLSDQEMLRLAACARALKVRKAQHQRVYKPRMELWDDGGSPLVTAVLEVPGLRPADVTVDVVDGRLVVSGERRQQGFSMAPKTQASPIANGNGSGNGTGTNPSEPTDPDVCVRASEETLAHAGTVTVLQVRELKYGFFRRVIAVPAGCTSAHLQASMENGMLTVSWPRDPGARLADLLLATKTESALQLNTGAGAGAAGSGFTENGSAACV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6K2</accession>
    <name>A0A2G8S6K2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_09455</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6K2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6K2"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="16">
        <location>
            <begin position="96"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="15">
        <location>
            <begin position="885"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL29403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="951" mass="110207" checksum="B09A4009B80DDD8F" modified="2018-01-31" version="1">MEVQLMARNATYTYSQQLAEQEYQKKEIRPVEEIVPKQYHEYLPVFSKEASERLPDHGPYDHAIELVPDARMFHSKVYPLSPSEQVELDKFLNENLAKGYIQESKSPMSSPFFFVKKKDGSLCPVQDYRQLNDITIKNRYPLPLVSDLMDRLKKAKYFTKLDIHWGYNNVRIKTGDEWKAAFVTNRGLFEPNVMFFGLANSPSTFSALMNIFKDLIILGKVTIYLDDILIFTNNIEEHRTLCEFEQPKVEYLGILVLENCVEIDPVKVKDITEWPVPQNILDVRKFCGFANFYQHFIKDFSAICKPLDRLTGNAPWKWEAEEQEAFDELKRCFTESPVLSMYNPDCKTRSMSNAECNYEIYNKEMLTIIRALQAWHHYLEGLPSVFKIQSDHKNLEYWKTAQNLTRRQARWALYLSQFEFVILHKPGTSNGQADTLSHRPDHQTDDADDNLDRVLLQPDRFRVLAAKRGHMSVVPEKALLRCIRECGECEQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGRVYVPKDDALRAEIVRIHHDLLPAGHPGQAKTVELVTRNYWWPGMVKFIKDYVETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCNFITGLPDVDGYNALQLIADRHGKIIHLIPCTEEIDAEGTADNFIREWFRLHGLPRKIISDRGPQFSSKLFRAMGNQNSGTRRLEAYLRMYCSRRRDDWVKWLPIAEFAFNSHVHSATGYSPFYLIYGFEPQFHILMLSMAVPSADEQREELHQAREDATSALTLVAERMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKCKVGNLAYELKLPKNLALYPVFHVSLLLPHKESRLPGCHPPEPASIEVEGEEEYEVEEVLESQRYGRWKKLQYLMHWMGWGPEHDSWEDAVDLANAPKIVQKFHSTHPDAPSPLNKKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6X9</accession>
    <name>A0A2G8S6X9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08338</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000021">
        <property type="protein sequence ID" value="PIL29530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6X9"/>
    <dbReference type="STRING" id="1077348.A0A2G8S6X9"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="301"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="531" mass="58545" checksum="1E33275DCFAE68D0" modified="2018-01-31" version="1">MTFSTLRALHAVIGAAIDDIELVYRERSDAQGSTLEYPSLDEPYYHHAAQHTPEEELAEELKADPAVAAATKRIVAACSQLSTTVNKPWFGLMEDMLWAQFSSAIRFLEAANIVEILREAGPNGLHVQEILRLVLELRTNSKTATPTDTVPLTPAHLSHILRLLATGHYLREVKPDVFTNNRPSSYIDSGKTVSQLREAPEKKYNDTNGIAAYVGVAGDESLKFMTTLVEWALPEKRRGTDTNFDYRAPPPAGGHDRSASTDSDSEGAVVTPRYVAPFHVAFNTQLNLFAWYELPENEGRLARFGHAMVGTRQCESKDEILRGFSWEDLPRGSVLVDVGGGIGAQAVVVANAHPHIRVVVEDRAQVVAGAREAWGPQYAHLFESGRMSWRVYDFFEAWPPLLLPGLGTVDAPDVFLLRGVLHDWTDENCKRQLLIGDMLLQHACADAAAYDTADGSAATFPFVTRDSPLLPNLGVANILGYITDLMMMDMFDAKERTVAEMTALTQSTGWKIIEVRRTPGAIWGYTTAVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7C1</accession>
    <name>A0A2G8S7C1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7C1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7C1"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41879" checksum="7DAE65E38A91B93C" modified="2018-01-31" version="1">MATVAGNSSSTTFTAEGAVSISFNALVSSPLSLTASIEKAFGSHPDSLGIIIVRDLPPTYTPARERLLRLAYRFANLEPNVRERYADSKSRYSFGWSHGKEIMNGKPDTMKGSYYANPVLDAPDVSAELRQAYPEYYGKNIWPTATAEVGEFEEAFKDLGGFVFKVGCQLAVACQPFASSYLSDSSLSLSNLIGSSQTVKARLLHYFPPSPENPLPAEDEAIDSWCGFHLDHSLLTGLCSVRFPSSYPDRPASEDAYYFTHQAMYLHKQPMGEPTVVQSPSPTSGLYIRTRGGDLTKVSIPVDCLAFQTGEALELATAGKLRATPHCVRVGAAPDAEKISRETFALFMQPNVDQQLSATENFGQFSKRIFDEHYKDESAGTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7E1</accession>
    <name>A0A2G8S7E1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_08119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000019">
        <property type="protein sequence ID" value="PIL29681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7E1"/>
    <dbReference type="OrthoDB" id="2986010at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="162" mass="18189" checksum="FDB27ACF303A7DF7" modified="2018-01-31" version="1">MSDEQHFATDRPVTVVAIPQGTPSPVTPFPPPPAIDSPRGRAVRLRRPDSVASMIGQWPVPHVMVYYRELKIAWGREAIAQMTKQDFMPWLFVSFVWMPPEPGVPFDNAHYDCSPFARNAALFATFYHTVGKDDCGPVMLGSLGWSEMIQNVARIELVYNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S878</accession>
    <name>A0A2G8S878_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S878"/>
    <dbReference type="STRING" id="1077348.A0A2G8S878"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="450" mass="50375" checksum="08E8E0D45FC626CE" modified="2018-01-31" version="1">MLMEMPVHMWSKSSVGGRRDGGVADAVQALFEGTMLKDVSDMDAAMAAVSRLIVDPDTPREEAVAALEAPAHILELVLSAASDDAYRVLVAVILEGYRRNLKGLLASPACRLLSRFALFYHFLPRSSATMDSMADETSRRRSQKAQAGTTVLRELLKLQFDGLWNREPSDDADGQLPFAILIKNGETQRARKRARRENRMPVVDYGVFSAHGITVPQTPAEALLLMRSICGAQCNMLKEYLDMFRRPDIVEAIRKAFLESPSDLPDDSAKEDAIDSDDEDVVDPASASSIHPPKAAMLLDTAEGLGEWHLLFTARAIRDLRQARDGKLFNIFMKKIRELSNGHFSDDNQKRLTAVDLEVPVYEAKMTGDTRLVYQVDCVREPGDEVERQVLKIHGIYTHAQIDRRFRGAIRRHLGEPKGAEYKKRCTFRSPPANPGDNVFAPATWRPRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8K2</accession>
    <name>A0A2G8S8K2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_08065</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8K2"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8K2"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL29858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="987" mass="109132" checksum="21C6A152916CF1C9" modified="2018-01-31" version="1">MAELPSLLLASLRPDSRKQAEQSLHSLSLQPGFLTHLLSLVLQSAQDRAVRLAGSVYLKNLIKSRWEDDEPPIPEADRAGLRGALVPAMIQLSNVSDKAVRAQVAESISLVAKSDFPERWPDLVDNLTVSLSHSNFEINVGVLETAHSIFRPWRAETRSDALFTEINYVLTRFTNPFLELFLHTTTLLFARPPPSNLAQVAQAMVFLVDIFYDLTCQDLPPGIEDSHAQFFGAQDGLFIRLLLWDPPQLQGEPDDTTPSLPSQIKTRILEIIELFVKLYPETLQNSGTVEAFVRAIWDLIGGGKRPGVADDGLVSQSLRFIASAIRTGYYKDLFGSKDTISGLVQGVVVPNVALREHELEQFEDDPLEYIRLDLALPSIGSGVSNEGVTRRQAAADVLRALVGSGHEAEATEVTGAWIGQGLNEYNANKAQSWRAKDTAIYLLIAIATRGSTTQHGVTSTNALIDVVQFFSDHVFQDLQAQEGSIHPILQVDAIRFLHTFRNQLVKQQLLSVLPELVRHLSSDNYVTYTYAAISIERILFIRQGTQLMFTEADVREVAPGLLNALLSKVEKAPSPEKMAENDYLMKCVMRVIVTARSTLAGGYEQILQRLVAILGVISKNPSNPNFDQYIFESISALMRFTVQANPGTLPTFERALFGPFTIILQQDIDQYIPYAFQILAQMLDLHTGEVPPEYRGLLPLLLTPASWQQKGSIPGLVKLLKAFLSHDAKSMVAAGQLTQVLGVVQQRLIPSKINDGWGFELIQAVIQHAPAAALQQYFRGVIVTLLTRMQTSKTDKYVYHFVYFLGFCLAINVEGLTPDYIIGEVDAIQPGLWSQLLVNFIIPQAPKSPPKERKVVVVGLSRLLAQSALMFQDPHTQAWAPTFQALAKLFQTEQLLTKEETDPDAGLTQIDYEEQTAGYQAAYSRLAAAEAAPVDPVAHVKDLKAFVGRELSQASARDQRVRGWIATTDMSITGPFVQALAASGFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8K8</accession>
    <name>A0A2G8S8K8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8K8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="121" mass="13390" checksum="7253BB2552779664" modified="2018-01-31" version="1">MARAGSRRQKLERWRFDVPSTPKLALSEGLAHLIQLLPSSSRPTFMSSESSESSGEPDSEHGHRHVQGQLLYPAPDKVVDDSHVGRQDRGARGDTFPCGPRNARPPSRRHAPLFLSRPGCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8U8</accession>
    <name>A0A2G8S8U8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07735</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8U8"/>
    <dbReference type="OrthoDB" id="2750355at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="486" mass="53215" checksum="250091977E0962B6" modified="2018-01-31" version="1">MNELNMPIHPNVNMDIMLAILSHSPPKTATSIMETCRFLYHEGAKVILQQPVFLWGSESQILALLRFIQAEGLSRCSYLRNLVIIIQISERVANIQPGRPSELVAADVNFDFSTHSSAALSHPFHLLQRSVSTLQRLAYTSSGHPDIDNTASQYPQIIYPEALPNVVDLEVYGISSILHEFPGLRLPEGQDPQMNVARHAPGPVKGSLAWKHIRTYTGPLSVLHTLGISFHIPRLYLTTIPGMSSPLALTEALVHIQPTHLTITYKDQPFSYNLGPDFVSALHSDGASRLPSLGLEIEVMAADVDSNIDVGKFWTSVGTALARLQLCDLCIVMSDISLPEAACASTTPPSSPDGGEQGAHTHELAPEAVEAADCPQCSEAAYRTPCTLAERTLEDFDLDAFAGSLLASVRTLRNAVVSVARPIRCGGGMRTRLLGQHDDLKSQMRVGAEDREMDGVMRETLLSKGLAHEKRWFSSRVRAQYRGMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S967</accession>
    <name>A0A2G8S967_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S967"/>
    <dbReference type="STRING" id="1077348.A0A2G8S967"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23411" checksum="4A85AB641715B0FC" modified="2018-01-31" version="1">MPPTKATKASGPLKQAKLSFASKRTTSANPAAGGKAAKVTRKQAQPPRTSSSSPSSTEPIVLSDSDTDRDGPSGDAEVAPAPKKRRLNANAQRVAAKYEEESVAVVAEPAAEPEPEREPLKLTDKRWRTLYGAARAQMDHLEPIHANGQSMVHHILRVFDLSYEYGPCVGVSRLDRWERAYALGLNPPPEVKEILMTKEGSMDNQFSQSVFYGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBB5</accession>
    <name>A0A2G8SBB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBB5"/>
    <dbReference type="OrthoDB" id="2758506at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="420" mass="45496" checksum="73C271102CC9AA4D" modified="2018-01-31" version="1">MDFNTMIQHTTRLEEYTVPVAVLLAFLLLIHQRHRFLPAASPDFNERYRRSVRPSGHIQRAASVAVAASAAVYLDELDADDTSGPTESEGESEGALEFSSSPSETPSSKAETDVFNGVATRAGSLYSLAEESPEAVVGVRASTYPPSSKELESSTVSGGQRDLRHSTRSRSVTASSTSVRSTLAATSSASKTSKSGLQSSASQAGHETASRIRQTSFAASPSTTPQPSRSSVQRLQPKVESDDDDDYVLDTLIPASTPLPPKRASTPRTPAKARFGRVFTPEDNLASDDLPPSSPLPPKQPSASARTPHSAFRDRSVLSGPSSVGSQDADDEADRVVVTAWFESSSDKLVDSPPDLRDHPDLRLGDLFYHSTANDYQLWIWEVNDHGVLCWVRVKFMSVRNGLYLTLTPGERRPSWGYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBF8</accession>
    <name>A0A2G8SBF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBF8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBF8"/>
    <dbReference type="OrthoDB" id="3232438at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="822"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="774"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1104" mass="123640" checksum="B92EF90282084BF7" modified="2018-01-31" version="1">MSSQCPGCLKTFTSSGLANHLAQTHQPACISARDAAHHSRSVPSPSAPSLPDDFDMDADPIPFEGDYFGTYSDVDFDDDPPSDSGSDPEDDDEFEDEVDMHGWEPPLRCTANVVAGQPAMGPVAMDDMPEDPAGSASDQHLTSQAERRAAEATFRKTRNTFIVPFPIDTAGTPIPPTDLSTETIERVTYQHYQKGLDGSDHNPYAPFSSHRDWEVARWAKMRGPGSTAFSDLLAIEGVAQLLNLSFKTARQLNAIIDKKLPNGRPHFQREEIVVAGEAFEVFFRNILECIRALYGDPEFTPLLLLVPEKHYTDETKSERVYFDMHTGKWWWATQKELEKEKPGATVIPVIISSDKTQLTLFGNKSAYPVYMTIGNLPKDIRSKPSRRGQILLAYLPTTRLQHIKSKAARRRTLANLFHACMTHITAPLVTAGLDGIEIASGDGVFRRGHPILAVYVGDYPEQVLVTGCKTGKCPKCPIPRDELGDDTDTSRPFRDFGKVLDALAAADEGPRAFTRACREAGIKPLYHPFWESLPYMNIYYAITPDILHQLYQGVVKHLIGWLQKACGADEIDARCRRMPRNNSLRHFSKGISCMSRVSGKEHRDMCRVLPGLILGLPLPGGASPTRLLRATKALLDFLYFAQYPTHHTSSLKLLDKALQAFHANKQIFVDLGIRDTFRLPKLHSLDHYRVAIEMFGTTDNYDTQYSERLHIDFTKDAYRASNCKDELPQMTQWLERREKILRHEKYIAWCLRSSVRPDGALAVARPPVLLENGSCTQPTPTSTASSSRTITTTSVSESSSSQPFAARVTPLPSAPTVAAAAVSVPIRRAPGRPRDDPASPRPRIQMTRHPSVKGVKFPQLVTTYGATFFRDALSRYVVEHNHPQLTRHQVEQQASKVFFNFYSVPVFHKIKIHVLDSEGLGLQDTDKQDVVHVRPARKNKYDDTIPGRFDTVLVRTADGNHSGDSPRSIHDFQVAQVRLIFKIPDKGMAHLFPRIPVSERPSHLAYVEWFSKFGRSPHRDHGLYKVTRAIADRRASIIPVDRIERSCHLFPEFGPVAPREWTSSNVLEKCGTFYLNARLNFCTVTDAIFKFQYYAASTGYAPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBX9</accession>
    <name>A0A2G8SBX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_05949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBX9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SBX9"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="123"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL31251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="423" mass="45013" checksum="5B446157765442C4" modified="2018-01-31" version="1">MSVTKVHSRQIFDSRGNPTVEVDLYTAKGRFRASVPSGASTGIHEAVELRDGDKNAYVGKGVSKAVTNVNDIIGPELIKSGLQVTAQKEIDDFLIKLDGTPNKGKLGANAILGVSIAVAEAAPFVLPTPAFNVINGGSHAGNKLAFQEFMLLPTGAATFTEALKIGTETYHTLKKVISAKYGIDAVNVGDEGGFAPNVSGAEESLELLSEAIKKAGYEGKIKIALDVASSEFYKEGKYDLDFKNPNSDPTKWISGVELADLYLGYVKKYPIVSIEDPFDQDDWEAWSHFTSKSGIQIVGDDLTVTNPLRIKTAIEKKACNGLLLKVNQIGTISESIQAAQLAQSDGWGVMVSHRSGETENTVIADLVVALGVGQIKTGAPARSERVAKYNALLRIEEEVGDNSVYAGEKGLSAGAEAPALIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC19</accession>
    <name>A0A2G8SC19_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC19"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC19"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="512" mass="56683" checksum="1AFAA38032E8A211" modified="2018-01-31" version="1">MSNFTLVDPKGWDCDLQSVYSAYIGYFQLHNVPWYDRSWGILFESFEEFLTFSWPTITVTDTWTGRAHIVVRLSTIGAFLKMLKTRFGETLPMVENILRVTPFETSQRHMRTISEYATYKKVFQTLPAVLLSAQKVRVRNGEPKAIRDLWASKDKTFLALDFEWSERNNASCLEWGYAAVRCGHLDIAGAWPPDPEPNYRRGHYIVSEYADKVHNRLKPSFPWAYAFGESQTVSKTKLPQMIQAIISSLISPDSETIPNTLVLVAHGTTGDLRRLEDMKIKLPHNLLVIDAMAFERQLYASGLRGVMQEPSGRTRDPASSLSLSTMLQSFGVDVQRVLHNAGNAAFTTLLGLQLLLAPDTKLPSPKLPHALGAMMRNGKGSPSVPPSIAFMAPPAGAFPHMPVGMVPPVPVPVPFPGMGLSPEIYQDVAGNRVSYSPVQRTISDFRDGRRSSTPSGLHMHSATSPGLTSQSQRLPGRQRVSSTNSINELGERVSSLHVKALTTGPGAPTHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC73</accession>
    <name>A0A2G8SC73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_06040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC73"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC73"/>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16859">
        <property type="entry name" value="ING_ING4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000535">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="377"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="268"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="431"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="453" mass="48706" checksum="EC4AB24AFE1D687A" modified="2018-01-31" version="1">MSRRQQHIMNYPTATASTPVDTALSLACLSEYAHTLDSLPMDLSRSYGDLRELDAVLSSSMALLTAKINELISMIENKEGTNDERLYLLAEISEEASRLKLGGEDKIRVACHAADGLRAHRAHMRTLLDRMPDLAFSRAAEQLGRKTVYPHVTSKPFYPPGMTGEGGRRNRRAAGASASYGGLLLNGAEPSPEKKKRRVQRDDDDDVTRTPSKKERLDGAPPQRQRNGARAKKVAAERPLSPTGSVASVASHLPQAFVAQNAAAVSRQAANGRAGSNSSTNKRAQEAAARRDAYSAQPPSASHPSLPAPFIANPTGVLPEPHTARAVSNGVVSEWPHGQLEGPGMPVARNFPQVSQEGNDGAVSAGGEPDGDAEDNRTYCFCDGVSYGEMIGCDDEDCEREWFHIACVGLTVPPTGTWYCSKCLERRQNQKKSGRGGKKRTAGGRSAARNHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCA3</accession>
    <name>A0A2G8SCA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_06107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCA3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCA3"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="112"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL31406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="571" mass="65080" checksum="35FDCDA73504862F" modified="2018-01-31" version="1">MSTIPSKPLPGNTPSDSDSGSITKGSSSPTDSVLEVPPEGASAPLKETRSFWRKPKHELDSIATQPSVFDDPVTLEIYRPPAVWENVHRFDPSARWTWREEYRIVRKIDLLIMVWAFIMFFSLDLDRSNISQANTDNFLKDLGLTTDDFNLGNTVFKLCFLIAELPSQLISKRVGPDVWIPTQMVLWSFVSLGQFWLSGRASFLATRCLLGFMQGGFIPDVILYLSYFYTKTELPLRLAWFWVSNYMAEIIGAFMATGLLRLRGVGGKAGWRYLFLIEGILTLVVGIISYFMMPPSPTQTKAWFRPKGWFTEREEIIIVNRVLRDDPSKSNMHNRQGLTVKKIWAIIKDWRMWPIYSLGIVFMVPVQPPQTYLTLSLRNLGYTTTQANLLSIPSKVLGMVLLLLFCYISEVVDSRIAVLVALQFWALPLLVTLYTFTSKTSPWAYFAVVTLITGFPYVHPVQVAWASTNSGGVGTRTVSASIYNVFVQAGGMIGANIYRDDDKPLYKRGNRVLIAITVMNIILYGLIWLFYRGINSRRDRIWNKWTAKEQHEYLETAKDEGNAKMNFRFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCM6</accession>
    <name>A0A2G8SCM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCM6"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="218" mass="23091" checksum="821B866C4A05284A" modified="2018-01-31" version="1">MFQFSCPTVGEGPAMPSSSAWTAFSWRISPSTRFAMTLAISSTTSFSPSRESAALVRPRRKSPASTDSLFPNAAGAEAVPLRSGDLSITSSCRSDATWIISTICARRTCVGRRASGAATVGTASAGGNGGGAGGWCGRCGGWREKDVWNDAVWSGMLGFQSLSTSARVRGRSSSSARPPAPSHSAAHFLRCQPEPKPFVAWEKRRTMRGRSCFDGCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCV2</accession>
    <name>A0A2G8SCV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCV2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCV2"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="307" mass="35067" checksum="DF48E72915D156D4" modified="2018-01-31" version="1">MTTPPPFTSPEDFTPVKGRARQYFCQLCLPPGYKKGQAMSLTAALRHERTNTKHLDKVQERIRNDWNYDPPCDWGPIPLPAGTTAWDQSWPADRADDFILFWLENMAAEERGEKPETMDSFIDRYNKKYQDWLDSWYTGETQEIGQEEDEEEADKVGEEDGWDGVPGLWYDGGSFFPHEDGFNTVYHLPAHRTGDNCSAQFKQEQWQACAADPMSEEWVIREDPREEYLAWGFAPDELPDLHASDATPPSQPQVTLPQMKTRGQKNSNGRRGKNHGQGRDDGGRKKQGRGATDAATHARRGQRAKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDK1</accession>
    <name>A0A2G8SDK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDK1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDK1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="28134" checksum="58C9E512C05D34B8" modified="2018-01-31" version="1">MSFSQFHPLGQHPHTGEPYIRLPAPFDRVIITPPRQGDIPRIVTILNDYPVKRWLDGPPFPYLDIHAEEWVTKNQEHSDTIMRELRVADEEQPKGPVVAVSGCPVGCLRGVEEDGTEVFLGAIEFSRCGFPDLLNQQEQERMVSSNDGRKRGDPDIVWCIGCECISNTHLGTLSWSSYTTSRLSRRAGAQSRADELRCANSGRDMGGAADGSKTNTGRDDYWESGEHTCVGEVGISDSKHCEEAESDECRRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SE29</accession>
    <name>A0A2G8SE29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06734</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SE29"/>
    <dbReference type="STRING" id="1077348.A0A2G8SE29"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="230" mass="25089" checksum="CCCA656A66773944" modified="2018-01-31" version="1">MSASTPLFETIEADDPGYEQRTSATGNISAASSQAPANARPPPQMATNLNDAESGIAGILRQSAHPAVLFFLYLFRTVAITVYILSGFFISNYVLSSVIVVVLLAMDFWNCRNVAGRRLVGLRYWNQVDDDGESYWVFESRDIAVYTFPLLWLALLIVSILKFNLSFVPIVVLALVFNVTNAIGFTYADRDAKQKWANNLASSGWSMGMGGIGGQILTGVVKNSVGRVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SED6</accession>
    <name>A0A2G8SED6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SED6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SED6"/>
    <dbReference type="OrthoDB" id="2245455at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37327:SF1">
        <property type="entry name" value="MICROTUBULE INTERACTING AND TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="390" mass="41258" checksum="9BFE8899141A52A3" modified="2018-01-31" version="1">MGTIHQRRGKSSAPPSSLGDAPSPTDSTASAASVPVVGSRIVSAFPASTVSSLGIGRSRAVSQPGRRPSIVSANSYPTAAPGGSPAPRKPSIPSRLNPSAPPQITVNTAILSPQLTLSTLSLTSPPLVPPPPIPYANIPTAPLSPLPSSAPSDPLRKPYHMMTLIRLTMTSKTGGYVTRRLHVPQEVWSQGGAKLTNVPEKIRVVEVLCSALEELAHWSAEYFGAGNVSSGMALGIGAIGRKEGEQWAAKLEEFSSVCDGVVGQFGKKLGVGEGFVTKKSSGVTSWGGRLTRQFDKITNGKNLDSPALYVQGISKLFQAVQVLDEHTKAAGPQGMAPLYAAFPMDVRAALDMKLRHASEFFAKVVLTFVIRDMALLLDKYVKKCEKWLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEG7</accession>
    <name>A0A2G8SEG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEG7"/>
    <dbReference type="OrthoDB" id="3267335at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="340" mass="35415" checksum="1084898725AADCB8" modified="2018-01-31" version="1">MLKVLVHHHGAPANAPFHSTSLLHLLLQLLSQPLLLSFLFVVFAAISIPPVAAAEGIIQSPKDGLSVIDSPAPNSVLHVGSNMTIAIDVSASNSGTFSYRSLEVYLVSATTGKNFTISNGTQLLTQEPASTVKHIDWPVATCLQTGEYNLTVYEASTLTSNDTSYFAIIPVPVEVQNNDVPDNDCASTLNVLQVQPQASDPPPVTLIPGRIPSNSSTVLSGTATNTATATATSPPAGGQVITVTAGDSDITIPLTDLPGTIVVEPSGGAPPTPTSADITSGFTTIFKTVAPTATETLTEIISQPITVTFEETFVSTVTGPGQTEELTVTYGWQPFDFVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEK9</accession>
    <name>A0A2G8SEK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEK9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SEK9"/>
    <dbReference type="OrthoDB" id="544277at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="226" mass="24597" checksum="69DB5DB348CDA39A" modified="2018-01-31" version="1">MCFYGVVPALVKDPTNPTPSEQKIIRSLRVFQAAMLKTPSLAGAKVDVVVIPATADGSPEDKSKEGGSEELIIGVATWLPPNVTLDFNFITTLRGGALKVAFAWGLTSVKRLLGDYTAAVERTLTKEFKARHLDRLDSWHLFEIAIEPSYQGSGYSTMLFQEAFRRAPPKPLHVVASKPANKDIYAHFGFEAQTHMVGVGEVDAAGLKARGQAATGLPEFVMIKWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF47</accession>
    <name>A0A2G8SF47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF47"/>
    <dbReference type="OrthoDB" id="2747524at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33016" checksum="25437C041C326DA0" modified="2018-01-31" version="1">MPLLRSVSLRICRQELHGVGWDVLAAILSAPHLRSFTFGRLLFSPREAPPETWIGTLAPVTAFRYDQPSYPSNLLEYPTQQETLAFILKRLHRSLESLLLPSEIAPVAVLSQVQWPELRELTLRGEFHQSAGYVAPFVSLLSGMSRLRALNLLLAVPVGVDRKQLTLWPQGYKSQLGLPWPDLEVLIVSFPDPEDHIYGELPQSLRHLSLRCTPHHVLCLWVPSIYRCHSPIPPASEMLDILTKISAPLLDTLQLEYLADDAADDLLRCVSQRFSMMDHLYIYSVYSKIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG02</accession>
    <name>A0A2G8SG02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_05401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG02"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL32696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="122" mass="13800" checksum="A5BB00BA402381D3" modified="2018-01-31" version="1">MHRLAEDLNNHPDAPTNNSGLLCAQLFHGWWIIRDCDGNYHQLPEDSYDFRALILPLHPGQDNGRLETLWRLHAGYLGVWPLQGCGIQDFQAYCTRFYELEGEAMDTGRDDPQEGGGANVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGH8</accession>
    <name>A0A2G8SGH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGH8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="67" mass="6997" checksum="5088D4357BDA26AA" modified="2018-01-31" version="1">MYGQLHGGHDALGDATSPLATLDPHEKTRSSKPRKPLATLEYGDTDAKPPKVASRKGPEGGQSGGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGI7</accession>
    <name>A0A2G8SGI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_04979</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGI7"/>
    <dbReference type="OrthoDB" id="2747112at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052035">
        <property type="entry name" value="ZnF_BED_domain_contain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481:SF10">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="7">
        <location>
            <begin position="739"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="884" mass="95540" checksum="FC209531B9C8D436" modified="2018-01-31" version="1">MNFFSNIYLRKDAGAAYLPGLPVRSIILEVDGAAAVEPFVMILPTDKPENVDAATIAGWLAALNGPSVDASGMSSSQRELLLTLVCGYRAFLELPPTVKESDFYTLSHKIIDAVFELAVLQPADQKVREIADWLEALLPATCFLPVLDDSYEPRDPGKLSKDDVASIMTTFASMLDPRVREVIQDIDLSSVVSAVPTSPAHGSAASPNSSTATTKSNARNARKKARKARKAAARRAADGASDVDATESLPSVAGPPTSDNVSAAPSALEAMPVAIDTVPATLDTVTTTAFAAADSAATGGPAHPLGENMRAARTVTVEEVSDIEAAMRRAPVLDVKGKGRAAVLEAISSEDEDELPGLVDVEGSSDEDGEGGARVDLVQVGSGSTCEKPVSVFSLIGHVLNLVVKACISGFQGQHSHDKFKNEFETAFRDVQELTDDDYEDDEVSEDEADEAREQADDEVIASVDDTHPELADTSDEYAAPRAALQKILKLSAKVWNNPNVRAEMSRLAKEAGLQSEVLVRPVATRWNTICAVLERALDMQEVATEVCDQAQFNKRDGVRLRRFVLSEEEWRMLDDLYQLLDPFAFATRQISSSDRALVHEVIPYMDALTEHLDKFSDDESLTPAVRMAAKRGRVVLNKYYGLTDETIIYRIAMVLHPRYKTNYFRTQDWPEDWISEAVDLIRGEWTARYKPAASTDKGKARAPGPARVSGRRTAAAASSRALFESIARGPSAENQDALEAYLEAPPLTTVEDPIKYWELRAQTESNPALARMALDFLSVPATSTDIERAFSRGRLTVSRLRYALGDKSVRASTLLGSWARIPGLVDEGEIVDIIKNGGVVPLATQVVPAAPVTVDSDSDSDIEVVAGPSSSSRGVVTHRASKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGX7</accession>
    <name>A0A2G8SGX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_04462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGX7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGX7"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="6">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="5">
        <location>
            <begin position="131"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="515" mass="55942" checksum="514C4E94FFC9EEDB" modified="2018-01-31" version="1">MAPKGGNAKKESGRAKKAENEAKKASAAETEKERKEADKWSQGSKTNKKQDDKEEKRRAELARKAENARLLAEEETSAPAKVKASPKASAAKKAAPKKDVGPAGPGAIAAGGGLGVVSAAAAAEDGAPKEPESYTATGIDNAIDLLEVVNAKMDKASVGTRAADIERHPERRFKAAFEAYKERELPNVKEDHPGLRLNQYHDLLFKQFQKSPENPQAEIVITEIRSVPPLNAGLRFLSPPTISSILLLILLTASTSPQPISPIMTRSLTISIPGSPGSPTSPPSLTMSSPSSPQRTNTLVMTRLPPHFFEPIIQDAFRSHFETYGPLYSWAPIKGFARVIMTYFSESDAEMAKESNDGLVFGDLRQEPEFVLRVYRADPTPIDSDETREHNYYLKPPANEKNFLISPPGSPPVGWEQLREDPPNATPLANDLIAALRKLEVQEESARRGPGVEVLLEPEDGVGISVCVEDCDAVVQIDGDVSMDEDEDWAYGELAPSRMRFRPPPTAMPPIAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SH07</accession>
    <name>A0A2G8SH07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SH07"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="71" mass="8117" checksum="7D6FFA4034F80824" modified="2018-01-31" version="1">MQVRKSGEKMDRSSIKQAGIQLGAAFRFKLEGDLLDNRDKPWGRIEELAEGPQLLVRLDNDTAEKMDSRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SII1</accession>
    <name>A0A2G8SII1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SII1"/>
    <dbReference type="OrthoDB" id="2734493at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="66" mass="7726" checksum="81481159356E1BD6" modified="2018-01-31" version="1">MHALEAHWKPSKIRTHYLLMHMLYGDRLVRPTPSPFEVEAVEVISHADMRCKADWSRYSDDKDGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIQ1</accession>
    <name>A0A2G8SIQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIQ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIQ1"/>
    <dbReference type="OrthoDB" id="2538345at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689:SF1">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="40542" checksum="804A94EFEF6C4F92" modified="2018-01-31" version="1">MEGPERDRPRGPDRPRRDDRRGHRSRSRSPANRGDYSRRRSRSPRRHSPSPRTRRRSYSRSVSPADRRDRDRDRDTHERRRSRSPSRERERRQDKDRDGDGDRERRRRSRSRSKSRSSSSSSDEEEERERERRHRRKKDKHHRKRSDSRSRERDRDRDRKEKKKKSKKDKKKHKSGAVGHHQWGKYGIINETDLYNKEQEFRAWLVEERKINPETITKDQTKKEFARFAEDYNTATLPHEKFYNMDEYERRMSALRAGEYVPPADDGYDPTADMRAHASTHKRRAIEHDSYMNKEQLMELRKVQNERIQAGKMKLLGMEIKQNMGVRMDGTMFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLA1</accession>
    <name>A0A2G8SLA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLA1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="61" mass="6458" checksum="5DEECFA9563BC316" modified="2018-01-31" version="1">MCTRDTDELEGVVEEDSKVVTVVAEPVEAAALRAVRAEAEVRDDCETAAVAGVVVLTPKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLT2</accession>
    <name>A0A2G8SLT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLT2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLT2"/>
    <dbReference type="OrthoDB" id="2803068at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="853" mass="92353" checksum="F7F354E96948A311" modified="2018-01-31" version="1">MSKLHALRAATRELCVIYLPYAPETPPVSSLTAAPSATAVVPGSPEAPFVASWRRLANGAVVDGREHLLSPCAYHSLPLPPRRIPALARPERKQLAVRVADRACDPLVAHLDVLGTRYLCRSSPPSPAGSEKAGHPARVVHILRTSVRHLSPKDDSDLDLHGIVGSGRLEAAKAWYSDKGHSLASEPIDTDHSLRKRLRSARTASGSGTSAGEPEIRLYVVVPAVSKYLGAKDGGVVERERETYSLDHSRSQRMDDHLWGPSCDLEKDDSIPTRMAALYHPAFAYAQKALRGLQDGLPPEHRDREPGENASGVTGNVGAPVALIDGGKDDGALDGHRFIAQLRDTLHGLSVVEVGRSGLDSKSKEAASAHAAALGRVLQELFDDHTLKVEVTPCGGGIEVEVEAACPTPYRIPTCYIVGKDKLVSACGSDSRSGRAPNVPESMVAYRDAMLDDKHVSIFAATCCPCLVIGTSGSTVQIYAVFFADWVYRTHLCDYVLDAADTDVDEKVHVMRKTARMLREVYARLHVGVSLGPPKHALLPQPAILMPAPLPVHLYLLDRVMLGQSNDLFTGKLKLPGPLNNNDGGPGDGDKSKESSRAEVRELPVHVKFTDNYGVAAHRLLAAHTDASGAPRPLAPQLYWAGEVVAGLWMVVMETLPRDVRMLCQYTRRNCSKHVAWGELEDVRTAVQLLHAHGFVHGDLRDGNVMLQRQPGHRAANSDAGSGLKKGENRNDSGTSHGAGDNGVGTAVVLAPRAYLIDFDSAGKEGEVRYPMDPNPDILWPRPASELPGQLVTKDDDVFMLERLLQAPEEPKGGDGQDDKASRKRKPGKEGDVDKRKRKRNDVDKGKHGKHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMB3</accession>
    <name>A0A2G8SMB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMB3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMB3"/>
    <dbReference type="OrthoDB" id="2801156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="54218" checksum="2D7AB334E51FD6CB" modified="2018-01-31" version="1">MFDVGRKQVYKTETERSKAILEVLGQLFDHPRTNGNDFTGECLTAHGLPALYYVVVEDDVVPGDAAWAYVRGMLEYQRRIASDRYKAVREMTCCPCLVIFRERGIVRVWTAYLTDKVHGRELFPIHPGSLSYCYFEEKETRLSLQILKNTARMLRDSYAKVHTGSALPHTPHLFPRPASIIDFLPSATPSSVAALAALNLTITDRVPGTMHPIPTFGGRRWGHFRGAVQNPIDGTYTPVYIKFTGRGYGEAAHRLLARHDPPLAPQLLYCDEVLTGLKMIVMEDVQGDTLDTPSTLSLSTGTPVLDDSDVLAAIDRDIVRAVRLLHENDLVHGDLRGSHVVIQRASDGATRAYLLKFNWAREVGQARYPIELDRNVEWPEHWELMRHSFIRKTDDECMLGRLRDSLAPLASLGCSAGAEVRLGVRERADSDPDEVEGAAGIDDEGDAAMGDRRPSKRQKLSPIDAGGLEGLTRMDVDDDEEVQPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN00</accession>
    <name>A0A2G8SN00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_02933</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN00"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN00"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013654732" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="174"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="552" mass="60017" checksum="6C931A1302EFB2C2" modified="2018-01-31" version="1">MKLFALVALFAAVYQPVAALWPQPRGLTAGASTLKLASNFQITVSGSTPTDLHDAVTRTQQFLTKDKLGRLVVGRGSGDAKNFAAAKSLSKLTISLEKGATPQPIATEAQKAPEDRVEEYTLTVPSDGSGATLTAKTTLGLLRGLTTFGQLWYDYDGTTYALETPLTIKDSPAYPYRGFMLDTARTFFPVADIKRTLDAMSWVKLNQFHWHIVDSQSFPLQIPGFTDLAAKGAYSAYQQYSPKDVSDIVAYAGARGIDVMVEIDTPGHTSAIASSHPEYIACPGATPWATYANEPPAGQLRLADDNVSKYIANLFTAVTQMFPSKLFSTGGDELNTKCYEIDAPTQASLKKAGKTLEQALDSFTQTTHNALKAKGKTPVVWEEMVLSHNVTLSTKDTRVLVWISSDNVKAVAEKGYKLIHAASDYFYLDCGHGAWVGAFPNGNSWCDPFKTWQHAYSFNPTANLTAAESKLVLGGQHLLWAEQSGPENLDDTVWPRAASSAELFWTGPGLNVSAALPRLHDVSYRFRHRGVKTISLQPEWCALRPGACDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN05</accession>
    <name>A0A2G8SN05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_02930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN05"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN05"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL35141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="211" mass="23655" checksum="D34468D32A60D878" modified="2018-01-31" version="1">MEVLNQRSALLSNYEVLTLLRELESDHLARTKTALRIKKEEEAAGLFPKHQAQPDDVCENLRTVEVEAIQYLSADYQPTASQSPEGIAKLTRSLAQWDLTKAEKLQVVNLAPTEAVELYVIVEELEDRLGDQMEDILNTVKESLHERAAPVNGTADDAHSTQRVQNNAVVYSEYQEDYQADGQWDYDDNEVVFDDSGEGAGVEGDLDVEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN33</accession>
    <name>A0A2G8SN33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN33"/>
    <dbReference type="OrthoDB" id="2781046at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013634504" evidence="2">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="363" mass="38245" checksum="66D1A6B67FAC693B" modified="2018-01-31" version="1">MPSLNRLLVIAVLSLSVYVQAAPVRDATGSYLGREIVATEHNAIVAPVDNFDEVNDDFDTTDSDDEIELGSGVQDSSTPEDLALRKGKANLKPAPKPPKVTPPKQKSTKAVPPKTATKPPPQTTKATTTKLTMLCYPRAYNYVAQLFRRDNPEFIGWHGTNSDTAAFWTSQGQLVQPVNADGLLDFLGLGPNTTDGGSGAESAIGPGVYVIDDQETAIAFANNNAQANPNTTAQLCAIFAKSSATWRTAIPKAFIPEDLVGDSADATTKAKLEQARLDHIAQAVPGVNATSVVKFALLDPQRSTGQLVLPAQIADQFTATCFSADGGAAPSGTSTFPDFSYNGTTLRGEWNIASETAGTGDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN54</accession>
    <name>A0A2G8SN54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN54"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN54"/>
    <dbReference type="OrthoDB" id="3193283at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="508" mass="55076" checksum="D4F68CB19B8043FB" modified="2018-01-31" version="1">MDDSFHHSATVALDAIFEVVTRERWSMSLLQETENSRSRINGLPPEILTLIFSFVSEPLSPPGHRGPSSARQTYDLLPIIQVCRHWRELALGTPSLWSTLCENGSGHTATASFHAHTQQADLAVFVDRARPTPALIGLLGSPSVGSRITELYLQDLNAYSPSQLATELLAFPAPCLERVFVRRRVLRNSPGAELGEAAGAAPSNAATEVFAGVAPKLKSLAFHDVPLLPANYFEQLTHLRLSFEACAIHWTLPDLLHLLSQCPSLEDANLLGLPTHLHLVQDPATQTVSLSCLRKLEIGDCRGQEHAATLMRAILSNLILPADCAVRLYGLDAHRLSPFSDLHLPLGEQCTVLSIDVSFVAITITLTSPNTRGSVSLELSTAGATSTLLQQSIEAFVSVCAASILEVTISSQRVWPAWCDPNLLLSLLPNVASVVLRDTHLVDQCLDAIRPCSSGGPERDSALCPNLAILHLPSPLSDLLLQKLRSVVSERQRCGCRTQLAVVDCRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNA0</accession>
    <name>A0A2G8SNA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNA0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNA0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45835:SF99">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45835">
        <property type="entry name" value="YALI0A06105P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="1">
        <location>
            <begin position="174"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="240" mass="27741" checksum="E72EDD34765AADCD" modified="2018-01-31" version="1">MTGQWLPIAEFAFNSHVHSATGYSPFYLMYGFEPQFHIPMLSTAVPSADERREELRQAREDATSALTLAAEQMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVPGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESRRYGRWKKLQYLVHWMGWGPEHDSWEDAADLANAPKVVQKFHSTHPDVPSPLNKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNH6</accession>
    <name>A0A2G8SNH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNH6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNH6"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="170" mass="19802" checksum="BA0A015318FCD2E2" modified="2018-01-31" version="1">MSIVRSFKATDLFKFNHINLDLWTETYAINFYLGYFCRWPDMCAVQETPQGRMMGYVIGKAEGRGPELHGHVTALTVAPEYRRLGLSRKFMAWLEKVSDENYHGLFVDLYVRCVNFAAINMYERFGYSVYRRVREYYSNLGLGFGVRDEEDGFGACSSHLICGWMRGRDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPU1</accession>
    <name>A0A2G8SPU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_02492</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPU1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPU1"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013916732" evidence="13">
        <location>
            <begin position="28"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="199"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="230"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL35762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="518" mass="53695" checksum="65444551A0C6A076" modified="2018-01-31" version="1">MQLALSFSTLLASVLVILSATDSGVQAAPAKRARTITLPLTRLHQNRGDVHPQVLLQQHINRSQRRIARMKGVAPPSKRDLEHNLAKRLFIPPGGRPGTIEIEKRFNRQGAKSSVSLVEEEDETPELESLAQHAGKAGKVVAAAKKGKGKGKGGANGTGNANGNTGTGAAAAASNLTPAITPTAANSLGLAIEAQDVGYIATIQMGTPARDFNILMDSGSADLWVGAENCQSESGGDCGNHNFLGPQSSSSFKDLGKQFQVTYGTGNVQGDIIQDDISVAGLALPAHTFGVATAESVDFSDNSVPFDGLMGLAQSTLSEQGVLTPVESLSEAGLIGDAITSFKISRLADNKNDGEITFGGLDSSKFDAQTLVTFDNVATNGFWEGAMDSVTVDGTDTGLTGRSAILDTGTTLIVAPPADATAVHQLIAGAQDDGQGGFTIPCDTNASVALSFGGQQFAIDTRDLVFAQADNTGTTCISGISSGQIVDDTTWLVGDVFLKNAYFSTDVTKNQISLAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPZ1</accession>
    <name>A0A2G8SPZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPZ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPZ1"/>
    <dbReference type="OrthoDB" id="2524557at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF41">
        <property type="entry name" value="HL07962P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="83"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="513" mass="56731" checksum="4B318CFB724A3DDA" modified="2018-01-31" version="1">MNPPHILIARNSRGSNTHNPSASLSSPTETHAAASGIFRSAGSPSWYLDCESDEMASSLSTNGDLDDPIEIDETFTRTSKFPGNVKIVVESTTFWAHKEVLYFASSFFKAALCGGWAETEKESGRPQSVSSIITISQPPVVPGSRPNLETHSEITFARFDPDMDPDEVDLDVDLSGSDGSDEETSIEDKVKAREDSLNKLEKSNPTTPTSPSENAKVKAPDVDVDGKAAEPSTLPRHHPSKRQGSEKDKRPDAIIVLKEEKASTFHDFLKYVYPHLVCTITWNNVEGLMNISHKLHVSALQNECLTFLLSHAAGRPIKAMRIAELFEEEELYRESSRFVLDNPGGWSDEELGTLSQATLLKLEKRRTWFLERVLKLGLVQIAKEYQCCLSCPDPINCARLLDEKYKQAYQAVFRFGPCQPSMVFRYLRTLEGVSPPLSLTHLSCQTTAKAFIATLFDRMFSLGVRGSGTDTAPLGARVAAVAGSATSGPRRHFLYCSLHNESAQRSKRSREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ33</accession>
    <name>A0A2G8SQ33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_01483</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ33"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ33"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="600"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="835"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="848"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="912"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL35823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1090" mass="119706" checksum="374734ADA0AD9BD3" modified="2018-01-31" version="1">MTSRIESVDYAHDIRPYLQLPHLLSLTWLAYPILSLVFVVFRLQLSSDSAQDAVANAKEDLLASCKAAEHAATSAASMPRYLAIATNQQITDAVNGTMNAARATLVLALTVMEAIINFVIDIYRSTLLCFIELIVRSVLSVLITLVNDANSLIQAAAGPIATALEDAVKVVNVFLSGASKVAGIIGLDVPSQIDTSGLEKLRNFTLPSSIGDSLQSLNNSIPSPSDLKGKIESIVDTPFELLKKDINDTFGGLSFDVSALPLPSQNTVTFCDQMDTSVVDDLGRDLVKVVKIGTIIMIFLILLLIAANCALEWYKWRSMKTHFQRIRDGLVSDPDVKTQRAPDGRLMVGMSDHDLMSIEGTMSHPLVTKIVNKLELLLRLSKPKKDKLIWFSHYVFHPPAMACFLIGFFGLLSVELQLLAIGPIQAKFQQQTAASVSDFSNLIATSINASMYNQSAAYATQVNTRVDHVQSTINDGVFGWVNGTTTTLNDTISTFYSDVQNVITSVFGGTPLNEPLQEFLNCFLGSKVNAIESALTFLHDNLHVDIPRVNDTVLVLSPQSVNEATQPIAEAAVGTGNSDNSGLVARVVAVYIRSLKQERIMFGIFAALWLFVVLMALCILFWTTYGRPLLMRARSRRGGNGQSPDHIDAFYGGYASEKHVEAGENENMHDIKLTDEKAEPGVGGHFWSSFKAPWGGKAARTDGGEPAPPYPQVMQKPEYQKSWDNILDSADFAPHEADAESNAKISRPFRLMALSRKPSERKGTWLSLFGMSKKEDAPELPENGLVYTQEREVLTDEKPQQSEPEPSALKSRFHEHLEAPAFHKPSFSKHAQLFKSISRSKKQQQQSPNQDDSFTDPLISSTERSDSFSTQPQPQASSAFPTDPFVDRFPAGQTFETQALTQLRPHRRSRSRPNLSISTDNTTFIPDNNLPMSVQTPASDDMPMPVPPKPWVQQDVKASTKAAGIPLPLYYGYERPPPGLAPAPQPAQVSSRYLKPPTLLPSLPKRQQQQVRIDPDTSTPVTRLMTTTHARKSSQAVDPFVTPFDDEHRVAPATLTYAVSWPRAAQNPFADPTAAPRRPDSNPFATAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQB0</accession>
    <name>A0A2G8SQB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_01617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQB0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQB0"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL35957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="262" mass="28576" checksum="A855A18ECDC065A9" modified="2018-01-31" version="1">MARRYDSRTTIFSPEGRLYQIEYAMEAISHAGTVLGVLSKDGVVLAAEKKVTGKLLDMSSAKEGGYGGSGEKIFLLNSNVIAGVAGIAADANSLVNYARQASQRHLFMYNEDIPVESLAQRLCDLKQGYTQYGGLRPFGVSLLYAGYDPHYEFQLYHSDPSGNYSGWKATCIGANNGTATSLLKQEYKEDISVEAAIELVLRTMSKTMDSTTLGSEKLEFATLTLDANKKPKAKVYKPSEIDVLLQKHGLGKKDEDTEMSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQF6</accession>
    <name>A0A2G8SQF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQF6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQF6"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="186" mass="20644" checksum="AEFB95C0C77BADA5" modified="2018-01-31" version="1">MDCASLLVWPGFSETVVVVIKPPKGLNLTGNPVLFGFLEIANADESYHVTYLGLAAALKGTHVDNTDTFFGVQIPAIFHLNSNVVNTTHNFTFQGTDFPSIMSRLDFGTPLFRFDLVQPVTTSLSSRDGVHVFERWAYTFPRDKKPNTLVKFAKRTKIANFGAYRILLRALKGTGDLTREEDSRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQH8</accession>
    <name>A0A2G8SQH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_01633</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQH8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQH8"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL35973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="619" mass="68353" checksum="5C78B1AD6F0F9024" modified="2018-01-31" version="1">MSSRAAFTSKTAWDALGVESGEETEGEVLDETTASQPDSASESAARPSKSALKKQKALARAEKRQLEKAARAAARAQKAAGSDVQPVDPAPSDTPTRSDDDSTPPIATSPVIVDALAASLEEDKTPEPEPEAKAEPVLAPKPVNGAARSLLKVNGSAPSAPPKEPPAPAPAVPSPPVRHVPAPASAPESKPPSYIPSEKAPASPPRRTDIENPPEKQLTPEEKEQVKKRASFLTRTLWTFIMIGGFITLLLMGHAYMVILVMLCQTLVYREVTALFSLKRKDGGENVRGRDPWSKTLNWYFFAVTNYFLYGESIIYYFKHVVFSNAQLTPFATNHRFVSFTLYLIGFVGFVLSLKRGYLKQQFGLFCWVHMTLLLIVVSSHFIVNNILEGLIWFWVPASLVICNDVFAYIWGITVGRTPLIKLSPKKTVEGFIGAFFSTLIFGLLWGTYFMRFDYMICPVDDLGVSAWSSEFHCTPNPVFVWRDWNMPLPLRMFLAPLLGSRTTIPYAPYQLHLLVLACFASLVAPFGGFFASGFKRAFDIKDFGHSIPGHGGMTDRMDCQFLMGVFTYVYYSSLIRQNHVTVGSVLQTIVSGLTLAEQLELMSDLKRYLESQGVSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQI5</accession>
    <name>A0A2G8SQI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQI5"/>
    <dbReference type="OrthoDB" id="2719712at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013876666" evidence="2">
        <location>
            <begin position="23"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="410" mass="44592" checksum="5FF1FC32791E5922" modified="2018-01-31" version="1">MDPLLLSLIGLLSLLLAHFVLDKGPQRERNRFSARAVVHPDKSAILEYTPPHPPHNNVNAVPSVTRVFNNLQLETGSFANPRPSSSEDLMVGDGLSISSALPIGKRANASALTTSSKETVPPPRAMSAPPRPPSRAPSVPPASSSGPPPIPPLNSSLWSRTTSRAGTPAPNGASPTPTPNIKPHPLTRSLSRLGSQPSKSVSAGNRSMSVPVVQPPTPGPSKPRPSALVVSKRHARKCAKNPRFVNVLPNGERPETAYFLSEGRKPLDEPPVEELMKKRPPLKIGDLYCHTTPSTTQIWIYLKAEANTYWEEINVGYVRELDGRMLSLTDAGKPNFVGDDWANKRQAKEEKRKNKGKGRAGAQHEDIDDDTDELYESEEHFAEKSRGQLLLDVVDALDLELHGMGATWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQJ4</accession>
    <name>A0A2G8SQJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQJ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQJ4"/>
    <dbReference type="OrthoDB" id="2748152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="355"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="437" mass="46119" checksum="CCA0A9120C2821A8" modified="2018-01-31" version="1">MEVREKGAETPLELVKQRLVKETQVTELSGTGDPVAAVCTSNDILFIATGDPRQQEDILGGGVGLVLSHIASPRKVKDNVGDGRHDAAVSVLTVSPGGKWVASGSADSTIILWDANLRILAHEWVAHVGGVDRLAFSPSDGQFLASSGKDNAVTIWAVGAQDVVDVKCVIALKEVERMWRVELCGWAGDSLLFTSRTKTKAVVRSWDTRTSTQRQLLAGGSIQVIPSSQDGASGFLVLSTKGNPSILRAREIDKDTGVRPIGFLACDGRTSPPKDASCSSGGRLAIIHGDARVLVWDLEADAPASARPLSELIYSGGNIQGIAVSPDGSQVLAWGGNSMTIWDAHDDFAAPGKLFEGHDDRIVTASFSPDGKAVASASKDGVVRLWNTLNGSCIATLMDHSDSVVCVAFSPDGHLLSSGYANGTVIIHLLRDIILDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQN2</accession>
    <name>A0A2G8SQN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQN2"/>
    <dbReference type="OrthoDB" id="2731524at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="902"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="983"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1071"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117092" checksum="E95CB6656CFB86FF" modified="2018-01-31" version="1">MSSDSNGHAPPYQPDPADAGPSNAPEVPMGKAPSPPPPVHGVKRRLRSTDKLVGFKSHRARGATSVKPLKLIRKGRPSVLRRLHHQAKMAEAEAFARKALAETSTTPPGSPSDTRKRTRRIGVGADEEASGHSADQDDLMDGSSEGEPEGMEEDDDYTEGDNGEKGHEEQMEYEVGSAGLEGPQPREHHATSSAAPHPSALLQQGVSAQPGPQQQAVSNAPGLALFSGPQPAYATTAQESRPDRAHAGVQLYPEGGQPSGAPPRQRREVQEAYPPGPYPSGSQPQGAHSPQGPQPHGVFSAMPYPPGSQPASTHPPQGRQSNAAYSVAGYAQGPTSAHMPPGPQPHGAYPAGPYSQGPNPQHALGPPGLPPPGAYPAGLYSQGSQLQNAQGPQGPHLQGAYSATASQQDPRFQQYAQGMQHQGAYAGPYHQAQGVYPQGPQHQGAYVVAQHGQVPQHGVAPGSAYQPQSQPSQSTSNSIHSGSALQRQRSYPPPQGSFDPPGMRFIAEDPSQPPQKRGVPLSRQSTASSVDSTVRGTPPPSSSGRAKTGRVPSSLRGHKEHAYHPYDPPPQPTPYVPPPRVSASVPPPALQPASSRGGPPIGPRSQAPNTQSNSAAQGPQSGAPHMPAVAMVLDKVQHVEDVFLDHAKQSQKFQDAMRGAVEQVQRDVANLTSGRAGTLAAIMPHATKAPRKVRQSRLKQVGEHLPPDFNTWTVQDRSVWLRRQKDQLDLLSRHFKKYLKKTLEFNSWGELVDNHPPLSDAQIELFAKRGTTIYDVFPDKKIHVDFEQSWAKFPFNREARKVLIADFLSHVQAGQYCNPPVDALYLTEHHVGESLDTYIDTCRRSYRAEVDPPSDDEKDRRADNACKGGRRRTLLQQRKLSAERRGWEKYDALFNRLVPANMSDDETDSEREETSSRRKGKAKAKAKAKAKGKGKEKPKKPKKRHWPRWTIIRSLWQSDELVECFHSLDKHYRRDWENPGRYSKQRRSSGQPPRRRLLKEGTRTEDGVVPKGLWRNCYSQEWVDTLREEQVVALQMIDEDFDLSLPYLAEDTSDEDTSDEDASDDEADMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR46</accession>
    <name>A0A2G8SR46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR46"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="10835" checksum="2A7318B78BAEA217" modified="2018-01-31" version="1">MAQGGRAGEGAVHEPHPMEHGQAGEKETRGEDVKETTATTWRGLAAMHRAARGGTTIYLHNTHPFVFVGSVPVEGADSFAGQGRWDSNLRSFVVRFVYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRC1</accession>
    <name>A0A2G8SRC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid:diacylglycerol acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRC1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRC1"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="74600" checksum="0A56A992C2A1E39A" modified="2018-01-31" version="1">MPLIQRFKKRNRSDSAISGAQQHTAAEDLNKVREDVEDKLKTLKHAEKRQADRRFFATRRFLFPLGLALGIFVGFLLIQPPDFSDFHTHLALLMDEFDITIPEFSTLDIPLMNFSRVEVEWQRLWQNIPEPWKLNNNGLEFTVGEKMAAQGLSAKYPIVLVPGIISTGLESWSTSPEYRPFFRKKLWGGFSMISQVTFNRDKWMAAVLLDPVTGLDPPGVKVRAAEGIDAASNFVRGYWLWSKIVENLAVVGYDTNNLHLAPYDWRLSFFNLEERDGYFSRLRATIEGFVLKWVESPLHGKGGSDWVENHIEAFVSVAGTHLGVAKAMSAFLSGEMKDTVQINPAGAYVLERFFSRKERQKLFRSWAGSASMWIKGGDDVWGNTTWAPDDLSNSTHSHGALIAFREAPSSLDEDMDLNNMTSNEAGTWILERTPTTFQKMLATNYSFGIERDVEKLKANNLDFTKWTNPLEIQLPNAPSMKIYCVYGHGKLTERSYWYTQTNYEYDEVQADFPTAICPDDDPQHGRNCTSPRSPLDMPLYRTTYIDSEYTDETVNPRVMNGVKMGEGDGTVSLLSLGAMCVEGWKRERWNPAGIKVTTVELPHNPVVTIPRGGGTTSDHVDILGSTGLNEIILQVATGAGEGVQDSFVSDIREYAKRVKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRG4</accession>
    <name>A0A2G8SRG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRG4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRG4"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="181"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="355" mass="39463" checksum="3CABF67CA6A2F653" modified="2018-01-31" version="1">MPGLLSLPPFPEDVPTHPLLVIDYQLIKKRDQAEMDKLWKAATELGFWYLKNHGVDQDVNEMFEMGAETMRLPLDEKMKYEQGDAGISFGYKAAGANATDETGALDTVEFINVSKDDALAWPGKVHREYPSTVNARMESTIKPFVEKSLAVNNTLLAVLNDKLGLPEGALARLHPREEPSGSESRCIKNPPPQNGMSEEQAAIGAHTDFGSLSFLHNRLGGLQVMVPGTEQWQYIRPIPGHAICNVGDALTIFSGGILRSNLHRVVPPPKEQGKFERWSLVFFTRPGYSMVLRPLSDESSIIAEAVAKLPEDKYNTGSTSLDWFTRRIKNQRIKNRTGPETWKASRGTEHRPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSI3</accession>
    <name>A0A2G8SSI3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSI3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSI3"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF3">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [FE] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="84"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="235"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL36673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="294" mass="31861" checksum="ACA82E2056619707" modified="2018-01-31" version="1">MLAEDYQQGLLDRLNDQVRGTALENKTIVQTIIDSARDPDKVLEFNYASEALNNSFFLENLKPPPADASSHEAHLQATTSSSPSLIRRILFDYGSLAHFKSNFSAAVLGMSSSGWIWLVTDQDGQLGVIPTFGAGTLLVRSSKPSAALLEWQRLTGEPVLQYFEDLPPRPAAPPAPSSGLPPAPAASSPVSGMAHGAPSIDPHTQARTIASYPIPRGTYGTRDTGLGLNETQPDASKVGTTLFPLLCVSVHEHAWISAGYGVWGKEEYMRRFWTVVDWAKVVKVYEKVAKAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSY1</accession>
    <name>A0A2G8SSY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSY1"/>
    <dbReference type="OrthoDB" id="2804766at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="157" mass="17179" checksum="ADEDA1A833F4EC47" modified="2018-01-31" version="1">MDLRTSPLQPPTAESPGSHASSDLGSYSALPSQMRRSLETFEGRDEDGSELPRDVGAGPARPRFSSPGLDCGHEPCQCGREPSLLSSESQRQTWNAITASPPAIPKDYISDGESSYGSSFPSTMPTPLRNFLEMFPDTQTQDHFEVEPSHRQDDHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST29</accession>
    <name>A0A2G8ST29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_00616</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST29"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST29"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="120"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL36926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="302" mass="33285" checksum="82F995AEE87D2A20" modified="2018-01-31" version="1">MSASQDALDNYEHLLPPSWKSQITTWLQEDTPSFDYGGFVVGEAPREAFLLGKGKQTAVLAGAPFFTEVFAQLGCEVEWHMKEGETFEPVKHVATVRGKARHLLLGERIALNMLARCSGIATQSKKIKDLARGVGYEGVIAGTRKTTPGFRLVEKYGMLVGGIDPHRHDLSSMIMLKDNHIWSSGSITNAIKQARKVGGFSLLLEVEVGSEEEADEAIDAGADIIMLDNIEGAELVGVARRLREKWSGKRKFLFESSGNITETNLHERAINEVDILSTSVVHQSVQHIDFSLKIQKPDRAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STI7</accession>
    <name>A0A2G8STI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_00779</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8STI7"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL37087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="247" mass="28127" checksum="3D70143FDCCE468F" modified="2018-01-31" version="1">MSPTSDAVDDGFETRLRRRAGAKASPLDTVPVDPAHQPRGLIANTPLSVCLISFLLGSLFSFGLLLFFTNGYGLYWWSTYQLGFFLAVWSTFHWAEFAVTAGWNRDKCSVDSFLLENGAMYHVAHALALTEYLLTLFFKPEYKQWPYVSLLGIMLVLIGQTLRSTAMVYAGSNFSHMLAYRKLDGHVLVTGGIYRWFRHPSYAGFFYWALDIKANIIEAEEQYLTKFFGDDYRIYKQSVGTKIPFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STW0</accession>
    <name>A0A2G8STW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyketide synthase-like phosphopantetheine-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STW0"/>
    <dbReference type="STRING" id="1077348.A0A2G8STW0"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="3">
        <location>
            <begin position="566"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117338" checksum="D97A91AFC2ED3049" modified="2018-01-31" version="1">MTPSPTFHSPRELVCSGKVTVPELFEWHAKENPDYPLYHFHDGQKLHDITYAQAIIGIRRAARYVKARITTPQIVGVIVNADTVTYTITQLGILRAGYTMLLISPRNVPAAVADMLRKTGCRHLLLTSDTPIQSLARAALEEVDGVTLHEMPAFDTLIPLNVPVKPEEDSVEDLPTTFDKNSLAMILHSSGSTNHPKPIRWTHKRMTNWTTTPWYGDVDFCQASLAVHGTPMFHAIGVLMYCMAANDGMALGVFPPSSPPTFPTPENVFAGIMKTSSDYVMTAPAMVELWARDPMKIQHMKTMRGIIFGGAPLDQGVGDTLASHGIVLHSLYGSTEIGAFAKFFPTNTEMDWAYFQLNPLLDQRVIDAGEGRFELIVVSDPEMPLPILNTKFEGKDAYATNDILDQHPSRPGWYKYYGRLDDQIILSNGEKTNPAPLETIIGEDPYIQGCVIFGQGKFQNGILVEPKQEYRFDPQDVKQLEEYRSKIWKSIERANELAPQHSRLFKEMIIVTSPGKPFSYNIKGYPRRSWILKDYQEEINTLYTVVEESAQSDVVGPSQWNTESTYTFLRTVVEKVLRKSIPDNADFFRNGCDSLQATWIRNTILRALREYSPALAKRLHMNVVYQAPTISSLTEVVLRVVHNDSTSLAASSADDLIRIAEQYSSELPARPSQLQSREGDKDVVLITGTTSGFGCDILEHLLRDERVGKVYAFNRPSSQAMERQLARFRERSLDESLLHTPKFQMVEAALDVPGFGIEPQLLSEIRASLTHIIHNAWTVNFALTLPSFEPDLKAVRNLLELSWSCPYSPPPRLQFTSSIGVFEHCTVPPPIPEIPLNASSALGSGYSESKWIAEQVLYNLADRAGMPSVVVRLGQISGDKTGHWNEREWFPALVKSAIFTRCLPDVEGEASFFLSYLAAGAFAEMRSSPESILHLVHPRPIPWHDLITPMAQELGVPLAPYTTWLAALESSGSVEGSEGDATRENPALRLLDFFRSFALGNEKPPLGLWQLATSKAVNASETLANMPQIGEADVRRWVAAWRKSGFLNASPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU14</accession>
    <name>A0A2G8SU14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU14"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU14"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="375" mass="41675" checksum="DE9671800F33BDEA" modified="2018-01-31" version="1">MAEYPRMDPYRRARYDQGVDAKIVIMGNTGVGKTSLLHRYTQGKFDPKNTTSTTGAFFVTKKVTVDGTKVRLQLWDTAGQERFRSMAPMYYRGANAALLLYDITNASSFEDVRGWLEELKKNCSPDLIIYIVGAKADLHQFRQVTSDLARLSLHTWFPPPRPPTPPPPPAAPSTFSYIRPRFTSFTSIRSVPALTTTTPKPQSPTPESDSSLSDARSTAIKRANTSTYTRPRAKSGDLLIPRSQSVNSGARPIPSRFAYRPGGWNEIGDGSSNSLPEDDDEADTGEDQEWGLRKGMELFEVSAKDDFGIQHLFDNLIAAIIEKKDKIERENEIKRRDSVLLSSSATPVWAAQADQEEAREKARVAAGSSWSCCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUR3</accession>
    <name>A0A2G8SUR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_01209</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUR3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUR3"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013560422" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="227"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL37515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="617" mass="65744" checksum="DCB7509F1DE4CFF9" modified="2018-01-31" version="1">MRSLSAWVALALAAGVCAVPSTTVHKVKESVVSPRGWVKRAPAPADHIIELRIALPQPNFDELERHLYEVSDPFHDRYGQHLSKEEVEELVAPEAESVHLVNEWLASHGVYEDGLTRSPAKDWVHIKIPVALAEEMLRTKYHVWTHDASGSSVIRTTSYSLPEHLHDHVELIQPTTMFSHMKSLKTTFHFSHFSESAKGSASVTADAPPINIPSASGGHVDASCNATVTVTCLQQLYNAAGFTPSTTNGNQIGITGYLEQFANIQDLQSFYADQRPDALNSSFKTILINGGQNNQSLAEAGAEANLDTQFAFGLTFPTPGTFFSTGGSPPFIPDDLTPTNSNEPYLDWLAFILAQKTIPQTISTSYADDEQTVPASFAKRVCNEFAQLGARGTSLTFSSGDGGVGDGEEDPALQECFTNDGRNVTRFVPLFPPSCPFVTAVGGTIHVPETAVFFSGGGFSDLFSRPAYQNAAVTKFLNKLAPGTYKGLFNPNGRAIPDVAAQADNFLIFLGGRSGLIGGTSAAAPTFASFISLLNSARLSAGLPPLGFLNPLVYAIHAAAPDAFNDITTGNNPGCGTPGFNATEGWDAVTGVGTPNFGKLKEILTFGLGSLDLASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV42</accession>
    <name>A0A2G8SV42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV42"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV42"/>
    <dbReference type="OrthoDB" id="2755889at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="383" mass="42345" checksum="37226C4151310A2F" modified="2018-01-31" version="1">MLPRVVLMSRASQLAAELVVVAITWWHAYQSAYQLRKYGAHVRTSISSILVYNGNIYLLCVPPPNCVDTEAQFRNERFLGTLYITDIVVNTKLPAALVGSILAIFYDPYLVCVQDGTKNPHRGEVANDLVDAILKAKAANGVPAIYHPQAEQEERLVKVYNKWKEHGGVWTAAAAKVHAKQLTHVQKGCLARPRNDIPTDGSRIEGSHKGWNSIMRAFPSGLEVMNALGHDHVLRHNVRLDMRDGCLDKSMFMYYTFGSHHIRLVNAGVKLWNTLIEAQKKNGPLPANIRALPALRPADSQEKFGLVKMSAETATQYSLATIKQEPGDEAIDLSPETVLDADRLLQEIGVDPALLAMPRCCRRGCDLSPLGPPVLEVQMTSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RLW4</accession>
    <name>A0A2G8RLW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_15194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RLW4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RLW4"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="622"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="772"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="809"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL22505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1032" mass="113594" checksum="48596B49AAF6C987" modified="2018-01-31" version="1">MAIATPRALTPEDQQLFDRYSYGARERAPFGCVHHAFEHHAAAQPDAVAVEHLGDFITYGELDRQANILANYLRASGARPGVRVCLLVQRSILMVVGIVAVLKAGGTYVPLDGSIVTQSTLEYVLEDSQATLVLTLKDYAHRVSGIPVFCLEGISELPQDATKPKDLSAPTDSIYIIYTSGTTGKPKGVEVMHDNVTNLVCLSPGNIEMRPGRRVSQLLNVAFDMAAWEILGSLSNGCTLCVRGKSSKEWRAVMKTVDIVIATPSMMAPHDPADYPNIKVVATAGEPCPLPLAEKWGKAAHYYNSCGPTEVTIVNTVHLHTAGTFLTIGGPVPNTNVYVLDEDMNPVPIGEPGVMWAGGACVSKGYLNLPEKTSERYKLDSFKNDGSYMFNTGDLGRWRDNGELEHLGRVDDQVKVKGFRVELDGVSAAMQTCTSVKNATALLIESELWGFVTPEAVKTECVSAATELIQPYYAVPTQYVTMSDFPYTSNGKIDKRALRQMALDKIRRDQAEKDQAAVVPTKPAFYSSSPYDGKLLADVLSTIPHSFPVYKMDIKEDAGAVLLLQPKSEVTSTSSISASPEKSEVSSAHEAGNVWDGYLDDELPEKTNGHYFRNVRHQIFSLYRRLFGVVFITNVAVFIATLAKGGANAQELGLIVVANLFCAILMRQDYVINAFFTVACSVPRSWPLAIRRVAGRVYHIGGLHSGCAISGLVWLVLFTVQATRELLNKERTSIATVAITYFILMLVIGIVLFAYPKVRTSHHDAFERAHRFLGWSTTALVWCQVILLTNDYRAPGETLGRALVHAPPFWLVTIMTGSIILPWLRLRKVPVRAEVLSKHAVRLYFDYVTPRPGHFTRISDSPLMEWHGFATISEPGKTGYSLVVSRAGDWTTKMIEQPPKKIWVRGVPCYGVLRITPLFRRVVFVATGSGIGPCAPCILEQRVPIRLLWTSPNVRETFGDKFVDQILAASPGAVVYDTRKHGKPDMVKLTYRLVKEFDAEAVCIISNQKLTQKVVYGMTSRGIPAFGAIWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RM54</accession>
    <name>A0A2G8RM54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_15286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8RM54"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11883">
        <property type="entry name" value="SH3_Sdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057827">
        <property type="entry name" value="WW_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF368">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23518">
        <property type="entry name" value="WW_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="8">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="9">
        <location>
            <begin position="958"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="270"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="839"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="839"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="862"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL22597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1376" mass="151906" checksum="E1BA5F2181525472" modified="2018-01-31" version="1">MHDPQASMSNDQPQAGDEQYISTFFCCALYDYQTNDSSSLSFHKGDIIEVLTRLESGWWDGLLNDERGWFPSNYVTVISDQEAEAALNGSEYPSSQASLPDDSMVDMAHTMSQALSQADDGDWLGDGDTDYQPPRAAGYPTTNGMSGHGEGQQNDFWVPQVGQDGRIFYVNTQTGQQSRDLPTEAEPDDEVEVAALAPQPSTRAGQSVAYGLGGTNSAGHGNAGFGIPKGARTPEPWVRRLADDGFSYYYLNKLDGTISWTLPETGSAPPPAYNDDGYSGPLSTKDMPPSSGSSIPRNGSSNGISPLRTESSASRSQDQSDSGADRFSIHSDDSDVYPPRRDRSQSSTSRARHPGNGFAHPPTTASSSMHSTSPSSHQHPSPPLELTAAEESARALQETLSPPSPETAVELSNQVREAIAAVLRYLKGACSPRRPEQYREVDQLVLTVVASVRNLLYVTATPSGHVPSHLYPRDPRDPRHTGNSQTLQSHLKAAHRKVAGTLSKLVLSALAMQYDPGLSSSDKPNRMESDVAELERAVVAFVQEVQFFQEQHALSNTLSRTPGAKRLLGVFSTANIGLGLPGAGVGGEWRGFGYVAPEEGIDLPQRILSDDVVIEYKGCLKALEARLGSLVISLRYLDSHPERVSQEGQSACAYLSWLLQSLCNINISRHVDVDGIRPESGLPSTSPSYMQTVDKARQLVRTLEASTQALYDDGATIFMAVQTLGHAALLPQRERATLVTAVESTMPTVRSNCGLVAQSLESLLAAGHDQASISQGDYRNSIEWRTSRINMVDSSIAAISRLAEIPVGDDEFVDMEHAFAQPTMRTATSVDSVVSSTLYSNTNQQPSQSSLDMSERSRSDSVSEPETPTWQPDNGDNTFMGPPSPEPPSPLDEDAVAFVDEDDPVLLGKSPPRAGKGNKLMKILGSEAPQHYISKLNADQKPWYLRPNYDQSEILIDPDGQVRAGTASALVERLTAHELGDTTFIKNFLITFKSFMTVDDLFELLTKRYWVTPPPNLKPTDLEEWTRLKQQVIRMRVLNTFRTMVTDDDILEKEDMYILTHMKEFASNEEVVTFAAAKQLLILIERAQRDGDAPIKTTNTVPLAPPAPIMPKTSKKLKLLDIDPLELARQLTLMEAALYKKIRPMECLQRSREAKPGKTADNITTIIQLSNRIANWVAESVLAREDSQKRARIVKHFINVADRCRMLQNFSTMTAVISGLNTPPIRRLKRTWEQVNAKFMSQLKVCESTIDTNKNFNNYRSTLARIQPPCVPFIGVYLTTLTFINDGAEDKLAGKMINFRKRQKAAEVIQDIKRWQAKPYNFQTVASVLSYLEESFQSYQDGVDYGDQFWNLSLEREPREREDEKMARLLQESGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMG1</accession>
    <name>A0A2G8RMG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_15384</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMG1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMG1"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL22691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="520" mass="58809" checksum="4466C093CE868A76" modified="2018-01-31" version="1">MADFKSWDPSSRHLASIAVVIVTFSFLYLRSFLARLRRPPLPPGPRPLPFVGNIFDMPQVRMWEGLRDLCAKHGAHVVISMDMVILGSSEVIFELLDRRSASTSDRKQTPSIPLMGHDTTFGLMAYGSQWKSHRRAFWQQFSPTGITKYHAVLREMTWRFLNTMLRDPVGLEETLQECVAATMLRTLYGFDAKGRDDRMLSLIWDCIEGTRELLISGGFLMDFFPILRFAPSFLPFHRKLAKWRTANVRFKDELFARFKAQSKDRNHETYPCMVGEVLASLSRDGKDEDALAGAERIAKGITLDAVSAGTDTTTSILLTIFFAMSLYPSIQQKAQAELDAVVGPDRLPSFDDRESLVYLEAIIKEAMRWMPSAPLGLTHCTREDEMINGYFIPAGTVLLANIWACLHDSAVYDDPEAFRPERFLREGKPNPDAQDPGAFSFGFGRRICPGRHFGLAAVFIYTASALHVFEFLPPLDDHGQEIRIEPRMASGFVSRPEDARCVFRPRSTRAEVLVVKHAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RMU2</accession>
    <name>A0A2G8RMU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_15529</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RMU2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RMU2"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF73">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013546732" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="53"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL22834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="549" mass="59864" checksum="EFE81201B98708E7" modified="2018-01-31" version="1">MWSFLPVLSLLLQLDALVHALTFDVHVRERANSLTARDTSHITPVSNTRNSEYIANITLGGRTIPVLLDTGSSDLWVTGSVSNSNDIGKSVSLSYAVGNAAGDIYTADLQFANYTVTNQAFLLVQDTSSFSVDIKSQGYEGLIGLGPNTGSVIRSKVDDASGDSVLDRIFTQNTTSANYLSVLLNREGDPNSPATGQLTISEPLPQYTNISSMPKLPVTKVHKLTDEDQHWQVLTDVNGILGPDGQPIEVKSIVPSAPTGQMVAVFDSGFTLPQVPRAVSDAIYGRVQGAEYNEESEVWTVPCDQLINLTFTFGGVQYPIHPLDVSSSDFNMVSSTGSPVCVGTFQPITSAFSLLGEYDIILGMAFMRNTYTLFDYGNFMENTAVDRGDPFIQLLPLTNVAAAHNDFVQVRLAGVDTTGDSAHALLPTDQMKHSPISAAEKKKQYEEMILSRWPYIFVGCLAFVLICIGLITWRCCVARRRRREAKSKQMRLPDTAPRSPAAHQVSFNHANDSYLEMGQAKAYPVDSGYPAYPAATYRTSTVSSQRTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RND5</accession>
    <name>A0A2G8RND5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_14339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RND5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RND5"/>
    <dbReference type="OrthoDB" id="2798231at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.370:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 17.6-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000063">
        <property type="entry name" value="Zinc knuckle domaincontaining protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL23032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="659" mass="75858" checksum="E054ADBB11DED40E" modified="2018-01-31" version="1">MDLCPGLRPLSHSRDSAWRIGMLAVEVNDEFITVLELIVVFAAVQDGLDFVFEDVVNCHWRGGRRFFAIDRITVPGRQAVDVDDCMALSHGEGELQPDVVWTELAWCKFASATGERNVLGAEPDLVSGFEYMRLWFARFEGVLHVLEAFIECWELDIINRLRQAKYFTKFDVRWGYHNVRIKEGDEWKAAFTTNRGLFEPRVMLFGLTNSPATFQALMNSIFADLIAAGTVAVYLDDILIFTSTLEEHRRVTHEVLKCLQEHDLYLRPEKCEFERTEIEYLGLIIRQGEVAMDPVKVKAVTSWPTPKNLRDVRGFLGFANFYRRFIQDFAKRARPLNDLTKKDTPWTWGTAQRLAFQSLKDAFTQEPVLTTWAPLRPTRIEVDASGFAMGGVLLQKLEDGLWHPVAYRSQSMVEAERNYEIYDREMLGIIRALEDWRHYLEGLPEPFNIITDHRNLEYWQTAQNLTRRQARWSLYLSRFNFHLAHKPGAANTQADPLSRLATYHITDADDNREQIVLGPERFATLAATSMDDSERETDTLEREIREATEKEPEVTWALKVLKERGPRKLANGLLEWEEREGLIYHRGRIYIPPDRDLRKRIVSLCHDAVTAGHPGTSLAATPANVTNLPDIPVRPFNRTTSLKDHGKRWVSISLRASHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP22</accession>
    <name>A0A2G8RP22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.77</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_14569</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP22"/>
    <dbReference type="STRING" id="1077348.A0A2G8RP22"/>
    <dbReference type="OrthoDB" id="73890at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579:SF0">
        <property type="entry name" value="PROTEIN-L-ISOASPARTATE(D-ASPARTATE) O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01135">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL23259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="215" mass="23211" checksum="F1B53C5D203CE718" modified="2018-01-31" version="1">MSRARIINSDRVVAAMGKVDRAHYVLQKSGAYQDSPQQIGHAATISAPHMHAHATENLLPLLRPGARVLDVGSGSGYLCAVLHQVLQDPADPRSTESKVVGIDHIPELVEWSIGNLREDGLGEAVEQGRIKMVAGDGRKGVPEEGPFDAIHVGAAAPALPAALVEQLARPGRMFIPVGTYSQQIMQVDKDEHGRVTQIPLLDVMYVPLTDRDKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP89</accession>
    <name>A0A2G8RP89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP89"/>
    <dbReference type="OrthoDB" id="2972750at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="286" mass="29384" checksum="145D0B20C1D8B925" modified="2018-01-31" version="1">MSTPTGPPFFDPSFTPTFTPTFTPSPPSPTSGFSSIFQSPGGPPLILVCIAAGLLLGAFIGVLLMRRMRPPPIAQRGIGAAAFFAGANQPLGEKPKLVDIHLLPPPATGVDGTGSAGHGTGKEKLGEHGAWGTVSPFAAQYLHPAPSADRPRSLFPSAQSPFASRNRTPLARLAARMPWADPRWRAGAHELSPPAGAQPEARAVQLAVTVSMPSPRHPSFLPPLPKSGSSHGVHAPPAHKGHDDEDPMPDCCIGTVVVSYGQGHDLNAAAPSPAAAAPAVPPAVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPI7</accession>
    <name>A0A2G8RPI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_14741</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Responds to activation by environmental stress by phosphorylating downstream targets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="12"/>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPI7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPI7"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07849">
        <property type="entry name" value="STKc_ERK1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000073">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="40"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL23430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="386" mass="43885" checksum="7D9B2F3E077182F1" modified="2018-01-31" version="1">MPDQAPAAQPAAATKAKHGHAASTVQPAPRKVRFNVGTQYQVLDVVGEGAYGIVCSAIHRPSGRKVAIKKIAPFDHSMFCLRTLRELKLLKFLSEAGVSENIISILDIIKPPSIEQFKEVYLIQELMETDMHRVIRTQDLSDDHAQYFIYQTLRALKALHSADVIHRDLKPSNLLLNANCDLKVCDFGLARSVRTAEPSGTETGFMTEYVATRWYRAPEIMLTFKQYTKAIDIWSVGCILAEMLSGKPLFPGRDYHHQLTLILDVLGTPTLDEFYAITTRRSRDYIRALPFRKRKPFAQLFPNANPLAVDFLTRSLTFDPKKRITVEDALAHPYLEAYHDPDDEPCAPPLDPEFFEFDLHKDDISREQLKELLYEEIMSFRPPPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPS3</accession>
    <name>A0A2G8RPS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_14802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPS3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPS3"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013788948" description="Transporter" evidence="8">
        <location>
            <begin position="20"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL23491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22526" checksum="77E1C1499B555F2D" modified="2018-01-31" version="1">MAVFSIFLCAAIFCLFSSAFYHTFSAHSPDVAARCNALDYTGIVVLTVGSFFPCIYYGFFCDPHLQKFYLTCICVAGIGAAYIVLNPEYRKPTHRGARTKVFIFLGLCGVGPTLHGLVTHGFYTLCVEMGFAWLLLSAACYITGALLYANRIPERFSPGTFDYFLASHQIFHFFVVAAALAHYASVLTAFGHWHRRLGECPAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQF7</accession>
    <name>A0A2G8RQF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_13489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQF7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQF7"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008636">
        <property type="entry name" value="Hook_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05622">
        <property type="entry name" value="HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="7">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Hook C-terminal" evidence="6">
        <location>
            <begin position="192"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="488"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="816"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL23739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="840" mass="95991" checksum="F06B8590103DCDBF" modified="2018-01-31" version="1">MSVDSQKKELNAFFSFFATFDLTRPVTTVADLSDGAALFEILSIVDVEYFRQPARPTAQPSDNWVLRFSALKKLYRLMTQYFSEVLHQPTGALEVPDLQAIAKDYNVNATLIMCRLTIAIAVQCENNKEIIERIQKLTESEQHSLMRVIEQIMTKVRSSADAGMEASMTEDDHYYQIQSERSRILSEKETLEKVYQSLLEEHRTLQTNFDDIVSEKDDAVAQMKQAQREADSNSKRVDARGDAMLRGEIDRLRADLQKSEDNLAMAETELDKQTVLVTDLTRKVDELQARADEATRLKDQLDEYRHAADKLQKTENVMEKYKKKLQEAADMRQQVKALEKQNADLVDKNAALEDEYRKVAAFKPLMESYKSQIAELETKASARSKEIDAVKFELDQTKTKLKVTQEERAKDSETLELYQERVRELELTSQRPVAASRTRPQPDGEPTGNMTEFTEAEMLGNGEVPADVDDDVAGLGEELDTAITGTTMTDLKLQVRKLQRELEAVRKNEADASRVLVLENLLEDANRMKARYEADYLAAHREKLILQNDLEEIRSGKSLGDGAEAAIALRQRLNETVDELDKLKQEHAELEVNFEAMNKELTVAKSDLTLVNRDQLDILKTLRESVDEDKAELEAEVERLRTQLKELSDKNKMQLEQINGLLLEKVNLQSEGLDQRDRMLQRERAIGDLRASLSGKDVPEDVKQRMLGLHEENVSLKEQYKTAQEKLVKAKAFIKQQDKLFKEEHAKTGGSVSSGAFEEAENSYRSQIRILEEDLARQKRLLSDATNRYRREQVLMLSVIHNSGMHTARDQLGYAKQQSQPGPTSWLKQQRQNLGPMLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQJ0</accession>
    <name>A0A2G8RQJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">High affinity uptake of sulfate into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQJ0"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902434">
        <property type="term" value="P:sulfate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000046">
        <property type="entry name" value="Solute carrier family 26 (Sodium-independent sulfate anion transporter), member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="10">
        <location>
            <begin position="528"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="769" mass="83472" checksum="0A2F50FDD73CEE9D" modified="2018-01-31" version="1">MLAELSKACKRLLGASDEDVPVISPRDWAGNIARDPVQQAIAYVTSLFPIFGWITRYNLGWFSGDIIAGLTVGIVLVPQSMSYAQIATLPAEYGLYSSFVGVLVYCFFATSKDVSIGPVAVMSLTVSQIIKYINEAHPDKWDGPQIATTVAFICGFIVLGIGLLHLGWLVEFIPAPAVSGFMTGSALNIVSGQLPGLMGISGFDTRAATYKVFINTLKHLPKAKLDAAFGITGLASLYIIRWACVRLSHRYPSRARWFFFFSVFRNAFIIVVLTIASWLYCRRHGGNGKYPIKILQNVPRGFKHIGQPQIDPELVKALAPQLPVATIILFLEHIAISKSFGRVNGYKINPNQELIAIGVTNTIGTIFGAYPATGSFSRSALQSKSGARSPASGLFSAVVVIVALYGLTPAFFWIPTAALSAVIIHAVADLVASPKQVYSFWRVSPVEFVIWFASVLVTVFATIEDGIYTSIAASLALLLVRVARPRGHFLGRVTLHNTKESSSRDVYIPMQPNKFLMNPQVKVYPPSPGVVVYRFEESFLYPNSSLVNDAIVDYVKESTKRGQDMSGVKAGDRPWNDPGKNSDLEAEENAAKPIIHAVVLDFSAVSHIDTTGVQGLIDTRAEVERWADRPIEFHFATILSPWIRRALIAGGFGVRGSAMSTHFHEEIAPVTRYHDQYIADPEHTEPIDAVSRTADPEAGVSVVPVSAISARSSSEQTVQSLPSESALMMLPDTPFFHLDLAAAVKAAEKGLSRAASIIDAGSVKGPGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR76</accession>
    <name>A0A2G8RR76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR76"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR76"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="98"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="571" mass="60513" checksum="8B3F73325BDFFF4F" modified="2018-01-31" version="1">MAVSDYLVTDDLTIILALVAAGLFLLHNLYKPQALVHPILLGRQSDVARVRNPSESAVYRNYGTGMLGRFPLRPTKDQQVVLDLVKPDVDAPRTLWSTKITNLQLRERVANVGAGLTRAVGLVPQESNVLLLLNDGIEFLVADLALSALLVPTFTVASASVISPVLESHPPSVIITNPELLQHVLELIYDAHESEHHTIVVTGDISGLNLPKVDHVKILMWDDIEADGAAAAKAALPVPDPNDVYTVSFFQTPTGDLEGVQLTHQNLTAGIAATRALLPPSSALSPLDTIVSAFPLGTPYGRAVAYTALFEGTGFATVDSTKLIKSESGGSAPTGMKDLRTSGVYSVSSPTLLFVRPDHLNSLTDAISQEASNSSWFLFNFAWRHKLAGVLEGYITKQSLWDRLVFDSARMKVMGKGAGTVRAVVVGGGPLEAQNLTPSRIALSVPVINVHSHPLVAGPVFASHALDLQTFPPSGTAPSASASDAYAFTYLAPVGPPSVNVEVKLTGVDDSAVEAGSDPVGALRVRGPSVGRPLSVEEEAQEEEERGWRTTGEHAKVAANGTFKVSPAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRL5</accession>
    <name>A0A2G8RRL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_13918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRL5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="217" mass="24823" checksum="70C720327421C901" modified="2018-01-31" version="1">MDPEHRALAHHLPIQVSHRALFQHQASHDVVPMSRELARPTHEEPNVFSPKAQLEPPDRRPHPGGHLIHDLVPFRRQVTCRRRREQHLHLLYRHQGRLRVRAVVRRQVHRPQQVPDPRRLPCTYVLRGQRNKATRPEQPARVLRAPPEPPGDELCVCLGFGHGRGRVGVHGKHDRDEVVAACPRAVLAREDDEHVLGRGVVCVRGHDWELCPQSVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRU0</accession>
    <name>A0A2G8RRU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_13954</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRU0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRU0"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="18">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="17">
        <location>
            <begin position="224"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL24201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="323" mass="35579" checksum="26224D8342EDF2BD" modified="2018-01-31" version="1">MPKADINKAGWEQSEFPILCETCLGDNPFVRMSKQEFGRACGTCARPFTVFRWNPGTGMRFKTTVICQTCAKIKNVCQTCLLDLVYGLPTQVRDTALGIESEAPTSEINREYYAQNMETKLEGSKSLLDVDKSAGAGKEMLKQLARTDPYYKRNRPHLCSFFAKGECNRGDACPYRHEMPVENELSKQNIVDRYHGRNDPVAKKIMSAHAATMGLQPPEDLNITSLFLTSLSATSTEESIRTRVLKSLPAVQPSQLKSVVHVAKTRCAFVNWKDRATAELAAQAWANGLEIDGETINVRWGRSKGAPGAKAPKAGPSVVVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS57</accession>
    <name>A0A2G8RS57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_14097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS57"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS57"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL24344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="550" mass="58778" checksum="EAB146B79ED2D142" modified="2018-01-31" version="1">MATHSTLPRRTLGMSAPASPDNMFHRPYPTVRTSAASSSVSLDDDAPGSRPPSSRSSPRLAPVLTPLAAGLPTINSPVTATGANSESGSGPTICGLPLKYVSLVTLAVQNAMLSIVMHYSRVSIPAAESYSPATAVLLNEILKGSISFVIAFLRIVYASDTSGLGPAGWFFSFRRVCNEIFSPDCWKLSIPALLYVVQNSLQFVAISNLPVATFQVTYQMKILTTAAFSVALLRKRLSSSKWISLFLLAIGVGIVQLQTLATRQVPANTHIGSAHESAPLHIHIMSPLKGFGAVTAACFTSGLAGVYFEMVLKNSKADLWVRNVQLSLFSLPPALLPIFFETHHPARGGLWANMLRNFGGWAWATVAIQVLGGLITAIVIKYSDNILKGFATSLSIVLSFLASVALFGFHITPTFVTGSSIVLVATWMYNQPPGKELVAITNVIPGKPAPPSFPGTPVERDAPILGQFPSEKKRASPFGSPRVFASALGMAEKPEVDRFGETLETSRYLNAPYGSPFPSRTPSPVLTTPPYSPHAPVFSNLGTQNSGRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS73</accession>
    <name>A0A2G8RS73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS73"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL24343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="12722" checksum="1AD4056629CC0D05" modified="2018-01-31" version="1">MNRSTRVTFLRTCLSACPISLSMYIVGSSLCPIGSGLPALAPPPLPPADGGTSSSASTGVPDEGVSRFGRSPPKPRGPYGSSSSTMQRCTRLRSPSYATTTSPLKKRPVTESLMGSDMNIGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTM7</accession>
    <name>A0A2G8RTM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTM7"/>
    <dbReference type="OrthoDB" id="2764371at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="148" mass="16247" checksum="79E288A840C56A9B" modified="2018-01-31" version="1">MSHPSRTVRRPVQRSGRIIGRFVATRAIAWGQPDLGDTCFVTTNTVIYVWKGVGPTFNLFLVICNADPGRAQPDMITIDLQDHTLYPGLGTSAFIGYNGDLPTGLCLIFGDQAQGERFTMWMSVVFLEAAAQRGQIPFRSLVASLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU33</accession>
    <name>A0A2G8RU33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU33"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU33"/>
    <dbReference type="OrthoDB" id="128924at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="161" mass="18941" checksum="946CC60DA4201C8B" modified="2018-01-31" version="1">MDRIRERMQALRVEADKAVERAEEAEAKNKKYEHLLLEKEQEITSLQHKISVLDGDLEKAETKLTDLKSAQEDGEQSKTANEGLQRKIQLLEEELDAADKNLKEAMDKLRQVDVKAEHFERQVTRLEQERDQWEKKYEEANDKYRESKRELDELVASMEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RU61</accession>
    <name>A0A2G8RU61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_12944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RU61"/>
    <dbReference type="STRING" id="1077348.A0A2G8RU61"/>
    <dbReference type="OrthoDB" id="3247158at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053242">
        <property type="entry name" value="PAM2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46651:SF1">
        <property type="entry name" value="SMALL MUTS RELATED FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="7">
        <location>
            <begin position="797"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="506"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL25055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="875" mass="94016" checksum="CAA81B4DB7D014EB" modified="2018-01-31" version="1">MTATLGPPSIAHLRPKSSFSSLSDSASLHNDNDPSPTPRFPHTHAQLAAIARLYKPDAFLGDPDGDQNISPSLVARAVALLDAEREDELKGLLKDMFGPISEDELEQHVLDLMHKHRDDIDNVPFLFLTPTRRPISRPSSRASTHSARLIPNRPDTPNSAPSSPLAMIFRRPHTPLSSPLGTSGPQPASYMSGRSESPGASPIITHAQFAVSLPSSPMLSPRLLNAKASEFKPIPRPLSAASSNPGSLAALRGETPSPDLWAPPSRPTSKLAIAAPLTPDSSLLHRSGTPNSSLRSSMRPDDDDDDPFDPFAAHAIPRSFHPSTSDDLLWGSSPISASSLSPDDSPFPQVFGSGMEHNGSSHETPSRQSRDDDMDPEMAAMLTDGMTPFDVLSSVFGATLAPSELEEALAANGYDFERAMTWLVDRSMASHPSPAQPRIQPVGNRVMLVQRDGHGVRSGRAAFHGPQGRSGGRFASNGRPVQGGNRVCRYFLAGECLRADCRFSHDLERALCRFWLRGTCAKGESCEFLHHLPQDIDVQSLGHAISRVDIHSGQLEHKHSASLEDFPSLNHAASPGRENTIRRGAVGFGRGEGGSYDPSRTRFASAVKKPPANHQTAAPKDAATLAARREAMGTSAEPLHPNTAIVAPKPSPRIKLRAPSLLPTLPMGDSVSKLYMAYRSRALRLGAARNACLSRAADAWRRGDGAAAKRFSREGHDLNAKMAAEMVEAAGKLVRERATLAEQAARGRPVSWSDDPGDRAARGRVCGAGLGVCLGIASQSIGGDTKMTPEERTEVMLDLHGLHSAEATEVLEEFLLALEREHFYGLGYIVVGEEKHTGTQDPARGASRARLAAGVLEKQKQVWTGNGWKQAICTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUG9</accession>
    <name>A0A2G8RUG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUG9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUG9"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="548"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="624" mass="68574" checksum="A1C8109D29C4C565" modified="2018-01-31" version="1">MTTQPSIQDILQNEFSPPLDTSLIAAIVADYVSGNDTKRHDELLQLREVLSNLASEAEKELFDSDEQSVPGFSQLQHSSTSLADDSSSFDYSNTDISGYTSSSRSDASGQSFSHPLGFLRAVFPQVSTDRLKKILASHGGSVDDLDMEALVEEVLTAEYVREFEERDLDESESKLMGYEGPWELVERKKKGSPKQKKHFKKGTTFTLVDVRQQQHARPSPSNSSPHTTAPDPWTQLASVASHLAMLIPSQPASYFQSVFHSPNYPSPAQALRAALIQISRQISKHSNDELTEEESPLLFSMFEILTTSQMYSGLNVEERDQLLEDALFALRATGCDPNTALDVVQVLVELDADLTTKEYAWGVYHQKVPQLKAATKLPPGPPNIPPPPNIPRRSHTLPSSPSPEKARWPPNAWNTVPVKPAPDGPHPLAGVIRAYSVQTPTKPARKVHGSGNGHGKGGKGEVGELRMTRSKALAVGRQWELQEQRRAALREAGKAWQKGHAKNRGGEIAFYFAERARELQEEVQREQLKRAREMVMRNRTVSATSESIDLHGLIVVEAVAISREYLSEYFSGKSVKIITGRGKHSVNGVGVLGPAVRNALTSDGWIVDTVDGGLIARGLTSSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUJ2</accession>
    <name>A0A2G8RUJ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_13062</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="13">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUJ2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUJ2"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0843">Virulence</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="14">
        <location>
            <begin position="66"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="13">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL25173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="431" mass="45182" checksum="D1EA888B26F6DE31" modified="2018-01-31" version="1">MNYNLPNVLHEHVAVVAPTTYFGTMKSMRATSFINTDLPTIESDPFVASLTGPTSLATVPSSCSTTITPACLRALYNTSDYVPAATDKNILGVAGYLDEFANRADLQTFFQRFRTDAVNSSFTTMLVNDGGDDQSDPGVEANLDIQYTTGISFPTVNIYYSTGGSPPFNPDEGTDTNTNEPYLDWLNFILNQTTIPQTFTTSYGDDEQTVPVDYATTVCNLFAQLGARGSSIMFSSGDSGVGSDCVSNDGTNTRKFIPGFPASCPFVTAVGGTIHVNPEVAVSFSGGGFSDYFAQPSYQSSAVSTFLSGLGSTNAGLFNRTGRAYPDVAAQGQGFQVVIGGRVASVGGTSASSPTFAAVISLLNDFRLSQGNSSLGFLNPLIYSTGATGFNDITSGSNPGCNTNGFTAGTGWDPVTGLGTPDFLKLQSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV38</accession>
    <name>A0A2G8RV38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV38"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL25198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="67" mass="7206" checksum="7705FA3C4D5C4169" modified="2018-01-31" version="1">MTCGTSSGLGRSLYIVSPKFYLVKAYTSQDRQKLRHTSAACIQHSRDSLIPPRALHAAVAVSVAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RW25</accession>
    <name>A0A2G8RW25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_11459</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RW25"/>
    <dbReference type="STRING" id="1077348.A0A2G8RW25"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL25709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="354" mass="40135" checksum="8DF99C7C08D0B239" modified="2018-01-31" version="1">MTHHEFHATPVKKYRPILTRHAHDFVSHLTKETIARVPVHLKHMSGANIMEATYGIKVLPEDDPFIELAEAGQEAVSKCAIGFYFVEIFPLLRHVPAWFPGAGFQRQAAVWHEAATRQLHVPYADYVRREELGKADECMAKALAEAYGTDDVAVRHAKMATATMYMGGVETVAAVMHTFFLTMLLYPDVQARARRELEAVVGTHRLPTFDDLGAVPYIDALIKEVLRWAPIVRLDLPRRLREGDVYNGYYLEKDSIVIVNIWSILHDDKMYPDPHAFTPERFLNDDGKLNTDILDPQDVAFGFGRRMCPGRFMAYETLWIAIATLLSCAEIYPAKDGQGREIEVKEDFVSAFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWH4</accession>
    <name>A0A2G8RWH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWH4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWH4"/>
    <dbReference type="OrthoDB" id="3222669at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="569" mass="61827" checksum="BD5C0AB0D9497B5C" modified="2018-01-31" version="1">MAAAVFLHNAIFAADPPSPPAATAATLGAGAHRAPNRRAHHAHDRRLSSVSSITLQTSTSDHSHPTESLIHPDHLGSSESSVYLDLLARQPTHPGSLTHPPDRTSGLTLQGDAVSPRERKERHEKEVRRRLRRLRLVQRVLWVIIEFLTPRHVLHPAALNTRSFVNARAAYHFTTGLGGQCDNSPAWGFWLAGSLVRLIFTAGVLTTYHAVSYKYMVTRRPSRRRHTPSIFRHSEASFRSQFTTITSSRSFRPMTMTSTSTVPVSSPTAVDGPGQTSPPRNLSGTMVDLLEPHSLRTHSRITAGDLSPSGPSKTMRRASAQGFKNVMTAPQDTAFRTASPSSSEGADTDEDWEDRYGRPVPRMVGGYASLPLNGSPPPKEDGVGPHQWDPISDSDLNEIASRFRSLVEQVTRDTNDATPQAHRENDRYEFPVSYDRDRDRDDAHFVLGRAIHRMPTIESLGSHEVISLASTGKGGFSRNSTRSNTLSTADAPASRSASRANSLDAAVSLSVSGDGLAAWSTGTLAETGELSQSPVSTNGTAVYFGSRSTTTSYHTARSAGVHTDELEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXH6</accession>
    <name>A0A2G8RXH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXH6"/>
    <dbReference type="OrthoDB" id="2755266at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013748616" evidence="2">
        <location>
            <begin position="20"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="213" mass="20696" checksum="C4CFA02EE033A556" modified="2018-01-31" version="1">MIHKISTAFVLLMSALSHGYYVSGAVVSLLVPFADPDNAVTANYLGTDAEGHTSWSVGVGVTSGSFTNTDFIPGTVVADATNAQEVGALSTVIDGVTATITATGECSLATATESGGGASAACSFSGQLVDAASGTTSTAVITTAYTSLQTLLAVQIPDTGSGAIPTAAATSGSGTASSTGSPPTSTSTKNGARKERLGWGVAGAAGLVLVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXI8</accession>
    <name>A0A2G8RXI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXI8"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="272"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="549" mass="61705" checksum="420082F3AA29B7F8" modified="2018-01-31" version="1">MSFTSDTYTAVAPALVSEFERKFYWNGISADPPHLIYRSDLDSNPFPHPTPGDRWPYLPVKTAYGVFNTPLNPVWSSVAPLINASLKKRGIARSVLKTARFVTEHENGEKTLGPIVIWIALHPGKNTPSDARDASPEMLRILAEHGVEDAVVEWYEGKVERLVGPPLLRVTDSTNPSYYVRRPLTAALGMPIATMEMEREDAQGSLSFFFHESRDSKGELSARVFGVSCKHVLHKDMTVDYEFEGSGASRQYVHVCGDRRYNRFATETRDLIRENVDEAVSLAEEITRLEQKETRSDPEEAEEDKAALEKKKRLLEEVNSNNRKLQAFFTETDAGWHTIGLRIIGSTHWAPKIAVDVDELRYTRDIGTFELDPEKFRPNFKGNVVDLGNKFSSSELKKIFWPNGTNPTGMKFPSNRQLRIRGAVPREFLARPDCFDENGYPVYIVGKDGNTTDFTVGRYAGLEAYLCDESGQESIEAAVYNYSKTSGNFSAKGDSGSLIFTGNGQMLAILHSGMPRGFSSHVTFGTPAFWVIQQLKTKYKYADFAREAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYJ5</accession>
    <name>A0A2G8RYJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYJ5"/>
    <dbReference type="OrthoDB" id="2662268at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="144" mass="15357" checksum="7C8110E93854157A" modified="2018-01-31" version="1">MLVVPQSRPAGASPFGRIPTVDNSGRGIPMAALAGTPDGMLRAKFPAIAQALDHFSKASTSKFSLKITWAGYEGMNFSEELTGTGLVKGMALAFDRFLREATSFAGKPPAANLRPQQYRLHDLMLIAIVTFSGNVFQAEVQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYS2</accession>
    <name>A0A2G8RYS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYS2"/>
    <dbReference type="STRING" id="1077348.A0A2G8RYS2"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000009">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051915">
        <property type="entry name" value="Cellulose_Degrad_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620:SF117">
        <property type="entry name" value="BETA-1,4-XYLOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30620">
        <property type="entry name" value="PERIPLASMIC BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013876653" description="Fibronectin type III-like domain-containing protein" evidence="4">
        <location>
            <begin position="27"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="5">
        <location>
            <begin position="733"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL26655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="813" mass="87914" checksum="72ED23C0335EE5B3" modified="2018-01-31" version="1">MLPPSASMRRLGLALLPVLVFSLVVADTPARNRFEVRDDLHFPLHARASNKDGTTPVYKNPSASIEDRVNDLLPRMTLEEKVAQIIQGDMDGWMDFSDPLDDTLVFNQTGLEAMMAQKAGSIWGGYLTPWDKFVYGVTVGQKYLMENTTLGIPALIQSEGLHGFTNNGTIWPSPIGLAASFNPDLLQKAAQTIADEAEGLGVSHIFAPVLDLSRELRWGRVEENFGEDPFLTGEMGHAYVAGLQSGRRRNVSSNAIGRMAATCKHFAAFGSPQGGLNTAQVTGGERELRTNYLKPFNRACVEAFSIMTAYSSYDGIPAIANKHLLTDILRGEWGYQYWVTTDAGSVDLLINQHGLCDTRECAAKITLENGLSGEMGGGTFTYLTLPDQVRAGTVDVKYVDETVKAMLRTKLSLGLFENPYPYDDYLSTLRTPETRELLHSMEQETIVLLENRNATLPLSKSINSVALIGPQVDRVSFGDYVFFNASLNGISPLAGFTQLLANTSVEIKYAQGCELWSNDPSGIPAAVETAKSADAAIVMVGTWSLDQTLLWTPGTNATTGEHVDLSDLGLVGAQLQLVQAVKDAGKPTIVVLVSGKPVAEPWIQAHADAVVQQFYPGELGGLALAEVIFGDVNPSGKLPVSFPRSVGTTPVFYNYLKGGRFVDPGQVLDDGTLVFGHQYVLDSPVPLWSFGHGLSYTTFNYTDLAVSKSTISTGEDFSVSVTVHNTGSRDGKEVVQVYATDVVSSVVTPNQELVGFQKVDLVAGASARVTISVNASQLGLWSLDNQWVVEPGKFAIKIGTSDQTFVNTTLTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ96</accession>
    <name>A0A2G8RZ96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_15687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ96"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ96"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL26841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="580" mass="64706" checksum="3CF09897EE21CEC2" modified="2018-01-31" version="1">MPSSPESASLALVLAVSALFAHQIFRKVETLCLPFHVSLLMLPPALVARLSVSSGRVEWTAFLNRLAFCYVTYIGALAGSIISYRLSPFHPLHRHPGPVWYRTSILFHAAHMVSGKQTRYLRQLHDTYGDIVRMGPNHLSIRDPSLVGQILGPAGIPKGPSTLSSHHYDTHVPFIGIQDVEEHSRRRRPWTRGLGPAALKGYEHIMSRRVHQLVDVLEQQQGPVALEKWIQYFTYDFMSEMVIGGGFEQLQNGDSNAIWATVGKGSQVATFLGQIPWLGVYLGYIPGITGLLKVLLEYALNETTRRLAQGSSTRDLFYYLRNEDLPDEAPPPTRLLLNDGVVGVAAATETTSTALISVFHCLLVNPEAYAALQDEVDRFYPQGEDVCNTASHRAMHYLTAFVNETLRLFPPVPTNSSRQAPHHSAPVVLGSLVIPPGTQVFVPPYALHHDARNFVFPDAFWPDRWLIASGQLPLSLSRLPAPAPASESPRGVVEARELDFDFVHNEAAFMPFSHRPINCAGKALAMQQLRTVVCALVQRFRIRLRLPEGEKDVARYKEEFEDSYLVANRAELPVVLEPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ98</accession>
    <name>A0A2G8RZ98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ98"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="153" mass="16335" checksum="FF0B943AD4D79870" modified="2018-01-31" version="1">MASPRSQSTHLARAAGSSSSGGSRGSQPRGAATSAPNTPSPGRETEQFRRTGYPDDIEHLAGPRLALARCQRHSNDGLRLLRHSSLPPRQPPTDRADQTGPSDTSGHESERVLGMTHISAVKMPSLNVYLKPHSQAGGRDETQEHSIAMRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZA3</accession>
    <name>A0A2G8RZA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_11075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000036">
        <property type="protein sequence ID" value="PIL26814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZA3"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="335" mass="36545" checksum="B07AB4728A5A1570" modified="2018-01-31" version="1">MPSATFNALLYQAYSHQNQEDFAMVCLLGGLHGVLSVLRVLLVYGLAKRVRQAQLSAIMLSLTILALFASTTIYVIVAVASDLADCQQTFVSVGYQLSLFYVMPPSADGFPTPLVKPAQSWPLFCSRTFTFMANVCFFQSLGSSGDSGRRIYQPSGNASHRLQGMEIEETVERILRGENRGLAGRETVRDSRQVGSGILRDMGGSPSPTSYIGPYIDRTAQAVVVVFQVAEYNSKTLPGPARARFRLDILGAFVNGALVPVIEIYPAFVVVAVVLNRSHVEKGLSENMESVPTLHMAFTLKVDTLTSGEGDEEGRPAIRIGRRSSMRRAPSRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZC4</accession>
    <name>A0A2G8RZC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000035">
        <property type="protein sequence ID" value="PIL26873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZC4"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="77" mass="8183" checksum="7683D2E87D80A28D" modified="2018-01-31" version="1">MLDTITYLGLDDAFVSVVENYSTDSRTPDLESSPSSRVSSTSAGCPGTARILVQNETVARVAGAMVPESVFLLDNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZI9</accession>
    <name>A0A2G8RZI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_10078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL26940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZI9"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="415" mass="44696" checksum="CA5209CE6B26669B" modified="2018-01-31" version="1">MAHSLIPAYLKRLSVLLPPFSAASAYMPSDTPHRYPHQSYDDEHSSRPPDIALSSPDYSTVAPPAPQPAWWNAFEPEQAVSPLTLRIPCNTSLPESTRNIFTGHLSELFQSSGNRESLPWSISDPPAVPDLNDSRAFMPPSHHFPPCAVSEARPPSIPSLPPVLSRHALASRGVASQGFPLPIIAGSITLNGMMRVAPTPSTPRDGPQPVGGALNASLGLAPFGAPSTIYPSNSVSTTLQLPAPDTGAGPAPSMELGLSTSPEATTMADKPGRNTSSCDGQSTTANRQPQRAELVPQSTVSYGSGCRLDLVKQGQNPARLSDFDAVAFQGQTFAQKTTFQLVFEGYTVPFHQQYNVLLDKGRIQPTKRRLAKVICKAVECFIKLHTDFEYGLERIELLSIGVVSRSSIRPVFRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0G1</accession>
    <name>A0A2G8S0G1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_10405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0G1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0G1"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="155"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="587"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="479"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="770"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="804"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="893"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL27260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="926" mass="101668" checksum="A86681B06DB80913" modified="2018-01-31" version="1">MSSPTQLKLPNSLPYPIKLLHLAAPPNTDVQRGTRLLDYSFAYLSPEGQTESRFGTWDSPLDGTITRWLFNKGEVIHRSRAEDSPAVSILEPCKHGIVFGGLCGICGKDLTRSDYLGSQMDHGGATIPMTHDRNGPTVSLEEAQRIERDTAQHLYSSRKLSLIVDLDQTIVHATVDPTVGEWIGEGEAWEARQAKKVAALEEKENEKEEGEKEEQGALGDPGEDEDEVNPNWEALKDVKKFRLGPEALGQPHQRGLKGKSKEKTIEQNGCMYYIKPRPGLLDFLETMATKYEMHVYTMGTRAYAEEVCAAIDPGGKVFGNRILSRDESGSLTQKSLHRLFPCDQSMVVIIDDRADVWEWSPNLVKVVPSSRIEDDFFVGIGDINSAFLPKLEPLAPVVPPPPPPTTAAAVDGADPALAVPEAEDEDDEDVDEDVVESSDALSSPAEEGLSEAEKNEMLSQNTLALEAQVEERPLAKKQEELQETAKEEAAEKAEHEASESASEGNGTVPTLPEQHEKREKPVQKALLKNDDNELDRVQQILELVHERFYVAYDVRKPDGEHRSPKKRSAKKHDAPVEYDVRTIIPRIRMDTLAGVHILFTGVIPLDQRPHTAEIWKTATAFGAQCHTELSNKVTHVVTNKDSTQKVDAARRCSGIHIVWLNWLTDSLALWRRQDETPYLLHPTFREDTGTPAAVASPASDAHQISSDPDPDANDWDELHVDSSAGGSGGSRAIGVLGVEGPGPGLDMDGEFTPQEVDWDAANNEVDEFLNEPDDEEEGGGEAGNVNTMGGGGMSEDEGSLTDESNSIISSTTSSPRTKRKRVRSLTPSEIGVRNGADADVLRSPLAKRKKLTADRSGASPLKEAFTAEQLHGTSRRTSEDLSGSRRSSPMNGVDDDDENTEDDDDGSEVNMIDDDFLARELEEEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0T3</accession>
    <name>A0A2G8S0T3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0T3"/>
    <dbReference type="STRING" id="1077348.A0A2G8S0T3"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="49"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="246" mass="25842" checksum="0C11A9B433759CB6" modified="2018-01-31" version="1">MCFPGKRLKSNHADDAPPPAKSPPAPAAPPAPAPATQPATPATMSSPKVAIVIYSMYGHIAKLAESVKQGVESAGGSVTIFQISETLPQEILTKMHAPAKPDYPVLAPGDLVKFDAFLFGIPTRYGNFPAQWKTFWDATGQLWASGGLHGKYVSVFVSTASPGGGQESTAIATLSTFAHHGMIFVPFGYAKAFGQLTNLTEVHGGSPWGAGTFAAGDGSRQPSALELEIAQIQGKSFWETVSKVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S0W3</accession>
    <name>A0A2G8S0W3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_10558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S0W3"/>
    <dbReference type="OrthoDB" id="2756746at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL27410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="301" mass="32585" checksum="E3544ECAC64158FB" modified="2018-01-31" version="1">MSSQSDSAVDDAWIAFYSAEFSNGYCAIAVAALTAYDWVLTLPREGQFFWTGKARPISAILYFSNKYLNLFTVAIATPLWQAPLSDQLFASSSTRSSQNTNIQLTVLIVTRMSAILADTLLIAITIWKFRHENLKVATMNSANVSAFLIGILYFIVLVVLNTLHLVLTEVSIGSEGPTSLVSNFTIPLSSILVSHFILDLQEVSQRTAIGLASNDALYTSNGLSERSVHFASALGSLGATIEPGRDLEDAFDEESPNGSSTMSQFSPSDGCGSSRHTKTDDGFAIMEIRREFGEGEVVLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S158</accession>
    <name>A0A2G8S158_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_10435</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S158"/>
    <dbReference type="STRING" id="1077348.A0A2G8S158"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="11">
        <location>
            <begin position="11"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="11">
        <location>
            <begin position="178"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="12">
        <location>
            <begin position="398"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="636"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6 9">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="122"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL27288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="79598" checksum="8CA75C05C12E236C" modified="2018-01-31" version="1">MSGRSSHASAILGQELFGRLPQTKVLLVGAGGIGCELLKNIVLTGFGDITLLDLDTIDLSNLNRQFLFRKKDIKQSKALVAAKTASAFNPNVKITPIHANIKESQFDVAWFRGFDLVLNALDNLDYHGDVDSIVAVPAWLTDASWKGGGLTRRSFFSDFFAPMFTRRKQSVTWSSRPDARRHVNKMCMAANVPLVESGTAGYLGQVQPILKDRAECFDCVPKPTPKTFPVCTIRSTPSQPIHCIVWAKSYLLPQLFGEDEDGSELDEAEKQGENASEIAALRKEAQAFKTVRAALRSAPTPNDVASSSSSAAKLVFSKVYHADILNLLSMADMWRSRAPPTPLDFDGIRDGSFTIPKPQQLINGVLPNGNGAAPVNGNGDAKSARAVTTEKQLNGAGLKDQRALTLQDNLELFVASTERLAARVREGEDTIAFDKDDDDTLDFVTAAANLRSAAYGIPGKSRWEVKEMAGNIIPAIATTNAIIAGLIVLQALHLLRKSYTALRNVHVQFKPSMPLSAIAMCPPNSFCGVCRDTYTEVRCDPARVTLREVVDGVLGVGAGEGEGEDGEDVERREVSVYEDKRVLSDPDWDDNNERTLESLNVTRGKFLSIVDEDGEYATIQVAIGVLPPNHPVDAPAFILPSPLPQPPRKEKPRPATPAPPTPPVSKKRPAPDDDIQELEGPSAKRARVDGVEATGALPFTPSKKRRLEEDGLILLDSAEEKIEEDPDVIEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2H1</accession>
    <name>A0A2G8S2H1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2H1"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL27944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="188" mass="20860" checksum="909FF1E7202BB54B" modified="2018-01-31" version="1">MARVRERPPPLGRIRPLLACERAQAQWSQAARLRPGDLGRGGTGRGERMEGRRGRGPRDRSWRPRWRQNAQHLRARVRDPRRAPAGWHRAPRARRRGHGERHPLSRRVPHPSGETIVDDVEAGVDHATVQARWKTAMGAGAARYMVVFAGQGLAIMDGIKPIKIGRDGGAACRSREAAAKGSLLAPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3I1</accession>
    <name>A0A2G8S3I1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000025">
        <property type="protein sequence ID" value="PIL28321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3I1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S3I1"/>
    <dbReference type="OrthoDB" id="2246127at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912">
        <property type="entry name" value="IP13529P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31912:SF34">
        <property type="entry name" value="NOTOCHORD-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="779" mass="87861" checksum="06D7082E3A678C72" modified="2018-01-31" version="1">MAPPSSPSENADFWWVLVPDVLDRAGKPRYRCTVCNDHKTHEKKYKTTHERTVTHQGMLEAHRFRIEHPGEDDSALHAAHEAQRALIDDAALQLLRSLLGGASMDSEGVSGDSPASAPAPGPGPARIDWGLLEAGTEAAVDYPLDREVIHTVAQDLYRMYSEEDNQDDGDLSEDDGTLEREDGDVEEGPPVPEPTVYVNDGVELPTAPRKRTMPEDDARRRRHWFPWHDKISCTLDVLMHLPRSVFSQRQLDLFLWLLRVNGVEDVPSVRSMLGLNAALQRACGVDTIPYKGALGHNYHVNALDQILAQEMANPRVRPYLHFYPEDTGGRYLAEARQGRRWLEEVADDVLTPMLRLGAQDFYIHEPALLRDGRVCMPVRWFNRVEGGKRVWYAKCWGMEPVVRETESGWRVIQQPFEIATDNLLKTFSEWCRDAELYAFPHPTHVWGKSIYPILKRIEKWTLNDPALGNPWRARSNGHRVLAVPLWMYCDDTSGNLSKKWNKHNSILFTLAGLPREHTQKEYNIHFLTTSNLAPPLEMMDGVIEQLENAQQTGIWAWDAQQQEAVLVVPFVLALLGDNPMQSEFACHMGMHAKFFCRNCWVKGHDASEAEKNHGARSSHQGDDTLSQVSDESEDLNPALEGESGESETESVGGRSRRRKAVESMAEMMTRVKAFVTRAKPRSKDETASKLRSYFETASVPGGKTSVAKERTASGIKDTFQLVFLEKLFVAVKNKRGFDAKQAAITAAIAELPRHTTNPIWRIKGMGCAILLLRFSMSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S401</accession>
    <name>A0A2G8S401_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S401"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="357" mass="36988" checksum="485F6FF8026B73B8" modified="2018-01-31" version="1">MSSFNWLTTITTTGTALGDHVFTLTLITPAQTVVSGEISVGYTVTVPNFGIPNPTESPSTVPTSTSSVLSSSTSTDRSTTSAPGAPPASISQSLETSTPPSTTTSFPTTSVSIPSTPSVPSSISAPSSGLSAGSAVGIALGVFAVASVTAVAGVFLFLQKRKRHRNRSLKSAHYPKRETKPSEGMARSPSLSQTWSWLGSLAVGSEPEPEWNHGLGASLPHPRDDTCPSSSSSPRTGTETGTGTGARTGTPGMEKSSVVDKSDPSTNQIVPPVAFYVDHTLVRIPQPPLPVKHSGGGERLLALAPTGYTHSLLPLYSSQAGQRDVEASEGPWYELETDGDGIRPRASFDPFADPASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4C7</accession>
    <name>A0A2G8S4C7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_08664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4C7"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4C7"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="201"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41450" checksum="FA0B677D2515E9CC" modified="2018-01-31" version="1">MPATTLPPAPRWVPPPPTKENLDWADLPIIDFSKASTPEGRAELAPRVCDVMRTVGFMCIDWASLTDDQTDRIFDIGDVVFTQVPEAERMQHASKLAEEGSKIGYKPRQLWTIDNGVRDQHEQYACHRTVYGGQKHPKALEPFLPELRAFSEFNHYDVLHNILRILALGMELPEDTFVKMHGFDAVGDSHARWIKYHPRTEEDESKTNSVWLKGHTDTGTVTILYSQPISALQILSPDGKWRWVKHIDNALVVNIGESLEMLSGGFYKATIHRVVQPPADQRGRTRLGTYYFALADDAVRLVPVASPALAQGDVARKFADERAPTMGEWRRMRYMAYGLKEAVPVGGDVARQEKIVENGVLVLKYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S4J5</accession>
    <name>A0A2G8S4J5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Large ribosomal subunit protein bL28m</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_08725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S4J5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S4J5"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_bL28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_bL28_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL28681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="142" mass="16555" checksum="3345C3360FA47312" modified="2018-01-31" version="1">MFPSIPLLDLVSVPFKRAQQGLFHGKMKQFGNSVPNSKQKTRRTWLPNVHNHRLLSETLGQRLRVKVSTRALKTINKASYGGLDHYLLKTKPDLLGWEGMRLRTMVRDKREKVLREEQRQKALLEKQQQKSKKRRPSTSRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S553</accession>
    <name>A0A2G8S553_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit gamma, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_08946</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S553"/>
    <dbReference type="STRING" id="1077348.A0A2G8S553"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL28900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="296" mass="32244" checksum="2830842C14E09328" modified="2018-01-31" version="1">MLARRTLGRIASQPTALGAAPSQARNMATLREIELRLKSVRNIEKITKSMKMIASTKLAKAQRAMQAGKDYGIANKEIFSHAVSEDAGKRKLFIVVSSDKGLCGGIHSSVSKATRRAIAEKDKVEEDSPVMVIGDKSKAQLSRALPKNLVMTFNQIGRDIPTFADAAGVADLILTSGAKYDTIAIVYNRFVSAISYEPAIVEIEPETLLKESPGFRTYEMEDDVTRDLSEFTLANAIYAALVEAHACEQSARRNAMDNASKNASDMINRLTMQYNRGRQAAITNELVDIITGASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S613</accession>
    <name>A0A2G8S613_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_09223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S613"/>
    <dbReference type="STRING" id="1077348.A0A2G8S613"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013600727" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL29174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="225" mass="22387" checksum="15BBA9E9EBC2A720" modified="2018-01-31" version="1">MFSSVLLLLAAAVSPALATVYVTAPVATTSWAAGQQQTVSWKDDGTAPSLANFGPSKVSVYVGSQTQQTMVQAIVASVDLSTTSSIVFTPDASTGQNGQYYFIRFESLSFKDPNNPAYPALAFSSKYTMTGMTGTFTADELAQISAAANSGSATATSAASAQTSAAASATSTKMTSVKASGTSSAASGSSTAKAASSGNGASTVPISALTCVAGVAVAVFSAMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6C4</accession>
    <name>A0A2G8S6C4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL29326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6C4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL29326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="221" mass="23386" checksum="15035FD6ACF3EAE8" modified="2018-01-31" version="1">MEKVVESLLITLRPRMRTGRRDFFGLDALLLAPLSEPRSLSPSTLGARAALSPGRSGSSLCKTRTRSGSSSSPNTTDSLKSGSMLNSTLPSGEATAVEPSESADAWTASLAVEWVPEDRADSVLDRIARSQRRNLGDICWLGDPLAENAVLWESRRDIVPGRGFSGDLNVDVVPIAGRTMEEEAAGSVSSRAGPKPSAFQCATMSSAKRDAVGLRPSSNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S6S1</accession>
    <name>A0A2G8S6S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_08403</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000022">
        <property type="protein sequence ID" value="PIL29461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S6S1"/>
    <dbReference type="OrthoDB" id="2756329at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL29461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="175" mass="19504" checksum="AC1C571C7F0165E0" modified="2018-01-31" version="1">MAYNPADPPYIALSTPYAWYCDGAETPAEDPDAWKRVIVLVAELTPKSICLVVCPVLDCDLAPHPCQPIVQVLFPEDQATLQSSDAENKVVRFHLFKKECASHFSLRFSDPLEFWDCVRLISNVLCEAEGHRSDLVLRMSQAIDSIPSHQPGQAAACLCANQKHVPRDEGMQMDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S730</accession>
    <name>A0A2G8S730_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08228</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S730"/>
    <dbReference type="STRING" id="1077348.A0A2G8S730"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003314">
        <property type="entry name" value="PRK04322.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="149" mass="15822" checksum="7AAF53C0A32F426C" modified="2018-01-31" version="1">MPDQSKHVHEDSEGEDEELADGDLSAVKPGFLEPCKMVLVVRTDLGMSTGKIAAQCGHATLACYKALQKTNPALLKHWERTGQAKIALKAGSEDELLELEAIAKSLNLAARSILDAGRTQIAAGSRTVLGIGPGPVELVNKVTAKLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S7V4</accession>
    <name>A0A2G8S7V4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_08063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S7V4"/>
    <dbReference type="STRING" id="1077348.A0A2G8S7V4"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="90"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL29856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="546" mass="59937" checksum="EBF7235D04D18520" modified="2018-01-31" version="1">MPQQSQVLSSPYGLSQPSLGRRLFASLTSIYTRPLASTIFKLFPLYHSLPSAATSDSDLPQAQVEPEVLMADMLFNDEFANIIDGKKETSPTTADIINPATEEVFARVPIATPAQLDAAILAAERAFPAWSATPWEARQAALARLADILDRHADQFAQLLMREVGKDRASAGFELSISSPWLRGVSQQRLEDEVRTEASGRVSKIRFRPFGVVAGICPFNFPLTLCINKFAQAVLAGNCMILKAPPTAPCVVLKFVELAQTVLPPGVLQVLNGGNDLGQLMVKHPRIMRVSMTGSTAAGKSIMRSAADELKSVTLELGGNDPAIVLDDVDVKQVAQVLFLGASHNAGQVCFTMKRLFVHERIYDAVKAELIAMAKEVKLGNPFDPDVTMGPVQNKAQYDRLRGLLADCEEHGYKIAYQSEVPSEGEKGYFIPLTILDNPPDECRVVREEQFGPIIPLLKWKDDDEVIRRANGTEFGFTSSVWGRDMDRIQRIADKLYHGMVWINEWGAVSADHPMSGTKHSGVGVECSKHGLSSWTFIQSFVVRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S872</accession>
    <name>A0A2G8S872_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S872"/>
    <dbReference type="STRING" id="1077348.A0A2G8S872"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="375"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="730" mass="82631" checksum="DBDEDFB79F3CB14F" modified="2018-01-31" version="1">MEVDDSNISFLPILPLPTVHVPATDYDDHREASTPLCIDNGSTHLRFGFCTSETPRTGINMVAKYKERKTNKPLLLFGEGIDIEGGARSQAKTPWEGDVLLNFDALENAMDYAFIHLGIDTPTVDHPILMTERLASPLHSRSLTSELMFEQYSVPSLAFCVDSVMSFYHNNLPSPPVPFHGDGLVVSFNTASTSVVPILDGRGLMSHAKRINWGASQASDYLLKLIQLKYPTFPSRVMPPQCNWMLQTYCEFSPDYTSLLRKLKDPLNLRAAERILQFPYTLPVTEEKTEEELARIAERKKEQGRKLQEIAAKSRQEKLLQKENDLTHLLSVREGREEVSKREWAETLKEEGFANDAAFDATIKKLEADLKKARKKEVDGEEAENEEPPSFPLVDVPDEELDEEGLKEKKKQKLLKAGFEARERVKREKEREREERAAEEKREEEERDRDLTGWAAKLRREQEAIMTRIKERSRRRAALTDRKSAASQARMKSIANLAADDRVPKKRRKAGGEDTFGADDADWAIYRKINTAAASSDEEEDFASLQAIEQKLLAHDPTFTEEHTHAALSSQRSALMAAFRPQYEEGDAQGKARIHLNVERWRVCEAWFSPSMAGVDSAGLGEVLQNVLARFPDQDKGRLVKNVFLTGTPSQLPGLSDRLHATLRPILPPEMPLEIVRAADQTLDAWKGMADFAKTEEFKTVGVTKAEYDEWGGERIKRWWGGNWNSSVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8B4</accession>
    <name>A0A2G8S8B4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8B4"/>
    <dbReference type="OrthoDB" id="3256331at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="2">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL29768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="211" mass="23538" checksum="937E4F043AC74DC3" modified="2018-01-31" version="1">MNVDSNLGHGLETTTLTLSPDDPSNTTISDTEPEETRLYTVSTRHRWNGTTTYIANVHGEVLASLERWLILNDRVILGRDQPVSLREDVSGRKYKWRGHTVSSASALELFMKDDEYAQPIARFDRPRKTSDGREEPATLTLTGRALEIQDLVVLSFVFVEHQRRKEEAQAPGGDIRPLVMTSHGRATLVGPAWTPGASNKERSGGREGEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8G8</accession>
    <name>A0A2G8S8G8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8G8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8G8"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34145" checksum="846F054454380274" modified="2018-01-31" version="1">MSYVPPESWLCNPLNTSKYLKLDKDERAFFKVTTRLEDDTELDHHILEVQAKAYKIFPYPCIRIFGFTRIRISRPPAYKHFLKLGRERANPIFIDLGCAFGSDLRMAIVDGYPIESCLATDLHGGLYTEGHNLFRDTPDTFPVPFLQGDVLDPAFLAIAEPLPTDSEAIPAESAPSLTGLTSLNPLRGHVSAIYLGKFLHVFDEAGQAHIARALAGLLSPEPGSILFGVQGALEERGPFNPAGSPDWTMFCHSPESLGRLFEDAFGGPGRIRFESRMVEEPGGPTYFDTWPGNKKPFTCQEWSVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8M6</accession>
    <name>A0A2G8S8M6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8M6"/>
    <dbReference type="OrthoDB" id="2757774at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="547" mass="60543" checksum="0EC23C92A246392A" modified="2018-01-31" version="1">MLDAKLNTDVFAVVSEFLTDYADVLSFSLVCSTLNRIATRRLLSMRPVSLKGDLSVQKFHTFLFADAVTRAPRVRALRIGGFKLPPWKIANEAEGSPSPLVDILNSCPNLEHIAMCFADGSTDDESSVVAAIAALKTLRSLEVSDWSENTLDLLHGISSPIRKLAIHSGAIRSPDALDEFLPRLAPSLEDLELMYFRVHWGSTLVALDAEAPGPDGHPPPFRALAQYPAVRSFSAIILIGAPLLDRLQHLFPALDGTLSLGDFDTQINRCPRDAIRAANRRAQDAAPGHAWKKLDRVICDAQMLYVLALRCPVRLVMIDKCSAGTVRYAADALRENPVPRLKLTLKYGRGMLDGVFTPDMAGPLSHFTLCLVYGNKKLHKRDAGAGDFGQLRWDRLLPSFSTPQRALLSALRPLRNLTHLRVLICCELHRPGDPIWGKAAYSEKFVDAVRGPAFDFAGTAAALVRAVPSLQYVFLTTCGRFIERVEGGEGARTWRSYDRWDVSRAWRVAVRDAKRPRRLVRLHSDVADTIIRNEELVLSETDKVGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8Q8</accession>
    <name>A0A2G8S8Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8Q8"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8Q8"/>
    <dbReference type="OrthoDB" id="10014216at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF2">
        <property type="entry name" value="PHOSPHORIC MONOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="265" mass="29543" checksum="CBF26828891C56C8" modified="2018-01-31" version="1">MATTEDPAPKSTLPYPPLHKDKKFVVLSDWDGTITTRDSNDYMTDELGYGMEKRRQGNLDILAGKVTFRDAFREMLESVSGNGHSFEFCKEELKKNIVLDAGFKDFYRYCKRHDVPIVIISSGMAPIIRAVLSNLIGEEDSNTIEIVSNEVEVHEDGTWSIKYRHPTSGFGHDKSQAILPYRALPEPPLIFFFGDGVSDMSAARHADVLFVKEKPDGENDLAAYCVREGIPHILFADFGRALAVVADVVEGRTSAKQALDRGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9H0</accession>
    <name>A0A2G8S9H0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_07591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9H0"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9H0"/>
    <dbReference type="OrthoDB" id="2751552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="373"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL30405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="736" mass="81782" checksum="8579840B7226F95E" modified="2018-01-31" version="1">MPATVKLSPSAFLAKIPGTEPYSQEHPILSDPISLEGINSGRQLASLFKRSIESVLDLVPESSAQIVDLGAYKPQRDSYGRTGTIVELGLALESLLEPRLASAVNLPHRRHQIAVPVEISFTAPLCEMDPGELPSLQRDVLLGQHRLFLYRILVQRTKARLVYLDHAGIRISDEFDWTVANSFLHLFVWKLAHMTPEELGFDPTAELATTTEVAALRCAMDSGLLPPHIREAARATFEGDYPVHRVLITVADPLPDEAFPVDPPVLLPPPSIPLGRSGPGVIPSEGHLFLVGRPHFQAERFVGRFTRGYVAFDLQAQRFCFLKDYWRPLVSRRRARPEHLVYERLHAAQTPFIATLICGGDVGGPRAQKTRVQDDFPENRTTPRAHYRIAVEEVGVPLKTFRGFRGLANLFAQAITAHGHAVKYAGILHGDISVGNILIKPAGRALLIDWDHARLVSELETGPVEPGHAGTWQFQSALLLRWPRKPYRVSDDIESFVHAFIYMVLRHHVTSIDNLPAFVEGFFDRCHYVRAELDGGVTTVKRGGDSKLLHLNATSSRFTAVGSPKLQALLDEIARGCAESYAAVDTKAMDRLYGIVRHVPEDRRRATQIAPPPQPISELDMSWVSRCGVKYEPRTDPPSPAPPTISPPAANATPSDPSEMTGFLADWDAVIQVFLVYIVDTNNQADQEADTRSKADDELKRREPERSNGVNVIHRRFHQQKRNVPLKPCRALQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9X5</accession>
    <name>A0A2G8S9X5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_07244</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9X5"/>
    <dbReference type="STRING" id="1077348.A0A2G8S9X5"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000011">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="133"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL30544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="844" mass="93253" checksum="04F4E82968AF3DED" modified="2018-01-31" version="1">MGEPRHRRDIKEIKDAYDYLFNTGYNVAKLKDAALTGRLFQGAEGAAGVAGRSMAWKLFLVPGEPLHDVADVKAIPPWNPLRAAREDYKRLLMEKMRAPDGGYEEGFTIPGSGASPARSEKAGGNLEKNNPLSLDDENPWREWFASADLRKTILQDVERTFPDIAYFRDAEVQAELTHILYLYSDMHPDIGYRQGMHELLAPLYYAVDYDSIPEDSRTDPALKEFCSRSWVAADAWSLFSAVMNGASRWYEWQEKKTPAVAEPTPLPSHVQVNMAVRDSQMKPYIAPIVEAANRVQSVLLKGVDPELWKALQTAGIEPQIYGIRWLRLLFTRELSLDDAMVLWDALFAVDPSFDLALWICVAMLVRIRNKLIPADYSTQLTYLLRYPANPLAAGGIAEATPIHPAILLIRQALTLQLSPTPTVGVSIIHENRNLLGISTEVPPPISPPVNRRQRQGQRGRSFANGSFSGSGSLVLEAGSSTGTHVRQGSSSLGLPETFARNLLERGESLGINKTVMNAVSELKKNLPDLATALGRLPLTPQPANAMYPMSPDRSVSERPPWEPRTRNEMEREVAQVRTLQKKLGDTVGWIVDTLLLDECDIQDDTGRKTIRKRKQEALESLAYVRDILKGTVHNIDEDRLLGEEEGKRRRDKQRREREAAEALSRKTSTPHPPMPAASISIEARPQGAGVRRSQESFIPHASSPNPITNPAPAPVVAHSAHPPGQPNRPAPLSSVPSLPSQSFPLPISPQASKPPNANIPTYNAPWNYTKSAFSSAESPIANLPRMPPRTSTTLPRSSPNPLGHTFRNHPQPPPSLLESANVNGAVSRDQKPKQTPYDPLGAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9Y8</accession>
    <name>A0A2G8S9Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9Y8"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013802475" description="Transporter" evidence="1">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11823" checksum="1650376F3CEA9E31" modified="2018-01-31" version="1">MICLKMPCLFVHSLASCLSAIQVVLIVRSRLESSLPCLTHSYPHFLAPSLISVVVNLSLPIPSFHVRYNCLALEVPVPARILVSCSPHRPPSCLSLFLLHLCSLRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA41</accession>
    <name>A0A2G8SA41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA41"/>
    <dbReference type="OrthoDB" id="2754741at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="185" mass="19696" checksum="44E5EE117EBE7C47" modified="2018-01-31" version="1">MDGPSFSDRQILVTAFKGRGKIKRLPITYMDLLISLKRFFTRCLSRSVYDGAPPGIRAPCAGAGEGRFSLYALRLMFMGICAGIRGCFDLDTELDSVQPKKGSGDEADPDVGVAPSTPAPADDASSSSTSTSIPGPPAMFGTNLNQDDDGENTPPWASTLPVTCAFAQNYSAMSTLSRCKLNDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA65</accession>
    <name>A0A2G8SA65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA65"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA65"/>
    <dbReference type="OrthoDB" id="3192156at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="301" mass="32999" checksum="7FADF57FCE4807D1" modified="2018-01-31" version="1">MSLLLAPIVEVYRLILQPVAPFTWFGLQLSTLDVVATFRLCVALRQIREKFWRDHVLKQKTVRADEKGILAPVSEIEPRSFVRDAAAALVVVYGGEAVMASALAIPPSFMYSGVVPAFYMAVQATVDKLPSVPIPSFQLEGPLALLDAFSRTYLLCNLIPPMVLQHTSPAIKENPWTLLLTSVLTANGGFFFTNLFSFFQPYALTLTTPSEFLPYGWTTTDLWCAPFITGLYSFLTHSQPFWADAHHVAFAWLGTAGAEKVPALDPETARAVCTLVLAGLFTTRAVKNFGPAAAAPKTKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA81</accession>
    <name>A0A2G8SA81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA81"/>
    <dbReference type="OrthoDB" id="2757062at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="359" mass="38913" checksum="ED3E6AD31737A7CA" modified="2018-01-31" version="1">MNGKVLLSGTVVLYLSTTTYMVALIWSWANRNYYVAQAFAALSSPLYDGADANAALRAIRQQSWMLTVGFGLNFIIGDAIVWWRACVIWQRKVVTFTGPILIFISIVMHQSSDSPNVCTIIGMATLEHVPNNHTLYIMIAGNAYGIVALILSFSTNVLATTLIGYKAWQHRQLLKQHFAEGRATSRVLKALALLTESGCIYCAILVLIFAPHTGCYYLVPDHNVQILYLVYEADPSSNSDNANFVFETVGNDFEYGCLVPLIAIYPTTIIAIVALKQSPIDAGGLSRPRQARRHGSALATAEGGTTSTVVFHHSMGVRSSAAAVETQGSVAGPPAPCMHSLETLTSQEKIKAAPEDAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SBH4</accession>
    <name>A0A2G8SBH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SBH4"/>
    <dbReference type="OrthoDB" id="2748713at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="67496" checksum="BD78ACF0F8DAF9BA" modified="2018-01-31" version="1">MGLFIRISTDQPQHRHDHLKLHKQQSAVPRRAIFARPLSFVNQKFAMHRFKADIFRQPRLNFDVLCLVCNSLTEISDVLSFALTCSELTVPALQRRLRISPINLSNDELVHSFHRFIFADEPARAQYIYGLKLPRANRLPLGEPPGSRLRPLQDPLMEILKAAVHLQYISFPTAIDLFPVLTAAANIASLRELHIVFADFGGDCRWSPWKLLGTFRSPLRSLRIDSSNDSANEGFSVKLIHDYLASFATTLEVLELHSIDFYPSPSPLTTQFTALRSLTTHTVLNFDESTMEVLLRLFPNLDNTLSLGFLGVMDGEHDLLGLRERSKEVQTARTWSGLDHVVCDVRLAFLMALQCPIRRMHITVLRFYGRGLLGPVLRDNCPRLLHLSLLNNNSLRDLDDLFPASEEVNALTHLVVFVDVEVRKVYGRPTSIPWAQFKDKLLDSMKHLRLTHLRVVFRYTVWHEATAAPSAIRERDAMYTAHETDLHAVATRVFDAMPTIQYVLLATCGHTYQCLPRNEAPPGATETLNKWHASKAWRAPDSPLTKGQGHSKAKASPVALSREAAETIVAQEELHLSREEEVKVQRCDDATARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC85</accession>
    <name>A0A2G8SC85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC85"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC85"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="153"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57359" checksum="BBD69BB8F4E5A2C5" modified="2018-01-31" version="1">MNGAQPARHGRPAPAGPTPPAPAAAPPVPPNSAGIANTTTNTNTNAGAAPPAAAAPARQTNGASVNGTHAPAAQKGKKKAAEQPVDPSQMYETLKNRIAALEEEEVHEEEEERRFAEEAQKSVSGMTETAIHAKYIELFAEFKRLERDHAKEKQKLVKDKDAAKGQLTKANQTKTKMENLARELQKDNKKLREDSKRLATCVEEAQEEIMQMKTDMAKRAERAKIQESKYREMPDIVVRVVCKYRAELYFKISRKTKLTRLFNAWTERMETNVVSTTSGKKGASPLVNGTIVGSTSSSGSVSGSASTMQFIFSHSGRTLEPDQTPEEAGIEDGDVILAVEMMDLTDGPGTEELDDGPQPVRQKLRKEWVEDPTEARKTLQNIFDGVVRERLKEVLRQYELRERHFECVVRSKELEVLLSRARAAEQKQLADAEKARADKTDDESKQLRKELEDATEQQTILINKLLSCCNEPDSERTRQFLQSLHGALHPKNEPHKHGSPGEGQNQKATNASRKADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SC89</accession>
    <name>A0A2G8SC89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_06086</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SC89"/>
    <dbReference type="STRING" id="1077348.A0A2G8SC89"/>
    <dbReference type="OrthoDB" id="412382at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07999">
        <property type="entry name" value="GH7_CBH_EG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.100.10:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013836167" description="Glucanase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL31386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="458" mass="49074" checksum="01B2A1117E96746D" modified="2018-01-31" version="1">MFPTLSLLALSYAAIAYGQQAGTLTTETHPKLMIQKCTGSNSCTTENHLVVLDSNWRWLHSVSSSTNCYTGNTWDTSLCPDPTTCATNCALDGADYSGTYGITTSGNALTLKFVTHGPSSTNIGSRVYLMDTSDAKYEMFKLKNQEFTFDIDMSKLPCGLNGALYFVEMDSDGGLSRFSGNKAGAKYGTGYCDTQCPHDIKFINGEANVIDWTPSSNDVNAGTGQYGTCCNEMDIWEANAYGEAVTPHVCNVQGQTRCSGTACGDGDNRYGGICDKDGCDFNSWRMGDQTFLGIGKTVDTSSKFTVVTQFHTSNNSTSGTLSEIRRLYVQNGKVIANSKTNIAGMSQYDSITDAFCNAQKTAFGDTNSFENLGGLSQMGTALDTGMVLVMSLWDDHEAKMLWLDSDYPLDKDASLPGVSRGPCATTSGDPTTVESQSPDATVVFSNIKVGPIGSTYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCA1</accession>
    <name>A0A2G8SCA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_06084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCA1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCA1"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006181">
        <property type="entry name" value="D-amino_acid_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF30">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00677">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="653"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="743"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="659"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL31384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="808" mass="88004" checksum="AF24E2C03C49CA2F" modified="2018-01-31" version="1">MSSESSQTPVIVLGAGVIGLTVAHVLSENGRYKIKVVARDTYQDLDSQAFSSPWAGANWSPMGKLSERTYRWEKATFNKLWDMIPSGLVLASPSKVFYEEGADLDGLWYRDLVRDFRVLDPSELSDTQKRGVGFQTVSVCPDHYLPWLAKELQSRGVEFVRRKVVSIGEAAALAGPNGVLVNATGLGARSLIGLEDKDVYPIRGQTVVIDNPKVREFRMEESIGSGRPMAADGNVTYIIPRPWPNATGFTTILGGKYQEGNWDTSFSAADAQGILDRCAKLVPAIKDKDTKILKHNVGLRPARKGGPRVEAEWLDIPYETEWITAEEGSAAARPTGKVLVVHAYGFGSAGYQMSWGAAEEVGSLVNSGLNLSNEMSGHPCVFLLGLLTTAAAAQLSNHTIDDEYGDSVTGALPEYFNHWVQGAECNRCGISLNTAKLFRGTWHGTATSPDAESIPNITLRFTGVAIYVFNVLANRVPSVDFSTDTRLTFILDGAVDGHFQHEATSSTDFVFNHLVYAHSDLANGDHVLYPSPFLTDFASAIVFVNLLSIIDLLVDLFTDIWVSSKTDVSPPMSSQQQAVAQTSGHLGAVVGGSIGGVAIFLLLLLALWVYLRTKRRTVWSWLPPYEGTGTESRHTRTFSSRELLEGILHITSLRPRPSENPSHRSSAPNTLPPTEGGDHETELARDSRPSLPPLFSDQLISFRGLPASVEGPCQETEVSPHTSVEVVVDGKLQLSDVGRRFGCPSSARSDTGRRSFSQTSMTRSFDTTANEEVLSQLASLRAEVAGLRAQQEAQQRLMEAPPRYGEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCA2</accession>
    <name>A0A2G8SCA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_06087</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCA2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCA2"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013970372" description="laccase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="31"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="163"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="366"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL31387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="520" mass="55495" checksum="C42CFDDBEEAE6A69" modified="2018-01-31" version="1">MSRISLLTSLVTAALIGRVYAAIGPVTDLTISNAAISPDGFTRDAVVMNGVFPGPLIIGNKGDNFQLNVIDNLTNHTMFKSTSVHWHGLFQKGTNWADGGASVNQCPIATGHSFLYNFNVPDQAGKILPYHLSTQYCDGLRGPMVVYDPNDPHASLYDVDNDSTVITLADWYHVAASLGARFPTGADSTLINGLGRSTGTVEADLAVISVTQGKRYRFRLVSMSCDPWHTFSIDNHTMNVIEADGVNTKPLAVDSIPIFAGQRYSFVLTANQSVDNYWIRAIPSIGTTGFTDGINSAILRYDGAAPIEPTSSLAPVSSSPLVETDLHPLESMPVPGTATPGGVDKAINFAFTFDGTSFYTNGATFTPPSVPVLLQIMSGAQAAQDLLPSGAVIELPSQSSIEITMPATANAPGVPHPFHLHGHSFAVVRSAGSTAYNYDDPIWRDVVSTGTPANNDNVTIRFRTDNPGPWFLHCHIDFHLQAGFAVVLAEAITSTSAANPVPSAWEDLCPIYDALSDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCF6</accession>
    <name>A0A2G8SCF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCF6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCF6"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="320"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="418"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="516" mass="57106" checksum="FF0ABA45A2055141" modified="2018-01-31" version="1">MSKRSATEVQTSQEGQFEPRKTPRSESKRKENVAEDEMGEFEDGWEDEYESDEEVVDGQSGKPDDNMDVDDEVMPPIEESEEPPQVPEAFIPGVHKLGKDEILEPDDSVYIMRHNMTTNWPCLSFDILRDSLGDQRQRYPATAYIVTGTQAQVAKDNELHLYKMSSLQKTQKENEDSDDEDEDDDEALDEDPVLEHRSIPHLGSVNRVRAQPLPASSPLPSVSQPYYVASWAETGKVHIWDVRPLIEALDVPGYTVDKSRTHTPAFTISSHGRAEGFALDWAASDGANPSALRLLTGDTHARIFLTTTTPTGFNALAQPFASHTSSVEDLQWSPAEPTVFASCSADQSVRVWDVRARGRQSVAGISRAHESDVNVISWNRASTYLLLSGGDEGGIKVWDLRNVKKAGTAPDPSPVAAFNWHSAPITSIEWHPTEDSIFAASGADDQVTLWDLAVEQDDEETGAMDTTEGGREVPPQLLFVHQGQKDIKEVHWHPQIPGAVISTAYDGFNIFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCL1</accession>
    <name>A0A2G8SCL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_06217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCL1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCL1"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL31515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="540" mass="59535" checksum="0569A61FC7481998" modified="2018-01-31" version="1">MLRLGCRRLSGAVVQRYTELVRHASSSSPHHHPNAPLELDPAFQTLLRDVEISLRNKMPQGASGLQQPRELEVFPRDSDPDVDYLTSAELDARDEGLSGKETRKSPAAAFGSQRIGAVVLPLDLQSAISQIVADSDKPTLHQDAKRLFSSETAAGEEWNSTYDIHYKSGKEAGRHALRDATAFATVALPSHYSAIYAVFEQLKQRLGPDWQVDHIMDWGAATGSGLWASGHAFQRPSDMGGRSSLDTEDVQISHTSLGSYLGIDKREGLARIGKRLVRDVDLGGISVVWQKSFHEDNAVDSVDGSNLVALSAFLLSSLPTHVDRKVLVKEMWESGAEVIVLIDHDFENIAVAREQLLKLGRKELEDPTLSDHALRGSHVVAPCPHDGACPLYHPGYGKLQCSFSQRMERPEFVRKTKHSGSGHENMDYSYVVVRRGPRPAHNIDKVGRIGGVGLREFAKRTEDSTPIAHLFLDVDHQKLADGEQASSHEPKLSEAAEDDYGLISAEITSALRQEAYSWPRLVFPPIKRSGHIILDVRLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCN8</accession>
    <name>A0A2G8SCN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MED11</name>
        <name evidence="6" type="ORF">GSI_06226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCN8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCN8"/>
    <dbReference type="OrthoDB" id="3358442at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="180" mass="19525" checksum="98F3112B40C04AAE" modified="2018-01-31" version="1">MENGSNSNGAPMDQGPPEDIEPIWMSSRTARQIYALGEVEKDITRLLSLAASSIALLSLPQTDGPEDEDLPKGAERSEKFVDVANEYFERLDGIHIAIRSSLAHIRQSRIAPSAINAPPPGFIPPSLGVGLPSGDAQGIARGNRGLQEERIERDAWKGILDALTRIKEARDKEKADAMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SD34</accession>
    <name>A0A2G8SD34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_06200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SD34"/>
    <dbReference type="STRING" id="1077348.A0A2G8SD34"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL31498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="226" mass="24587" checksum="EE69FAD4564A442E" modified="2018-01-31" version="1">MSKQFQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGGPSFVSLVSYLGADSREAAFLTQTVTLEDQTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQSTSLEKAKSWIRELQRQADPNIVIALCGNKLDLASRRQVSQEEAKKYADEEGLMWGETSAKSGEGVADIFTSIAKKLPLTAPPSARGGARPGAPGARTGVDLNRQAAAGQGQGDQCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDJ1</accession>
    <name>A0A2G8SDJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_06517</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDJ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDJ1"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF84">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL31813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30329" checksum="F55E579B1A763BFB" modified="2018-01-31" version="1">MPPDYEMQSYWNARFENESHFEWLGDGSDTIIPHLRTHLLSLRVPSPSRPARLLHIGAGTSSLSERIRELYHNIYGPQVDEQAIVNVDFAETLVAREREKEATLARGWLGTGMQWICADALKWKELEAALHWSKEERAFDLIVDKSTSDAISCAQDISYSSPDLSLHPVLKELLAAQEGQKLSVPPVQLLAIHLASLVCPGGLWVALTFSSTRFSFLSSLEPGDNALPSHAAIYWDVEKIVALDAPTGMDPEGGVYGPVVQHYVFLIRRKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF58</accession>
    <name>A0A2G8SF58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF58"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="100" mass="11341" checksum="1ACA86212C29FE79" modified="2018-01-31" version="1">MPPEPTRPPPPENRGWVRRIPTSTGRDSAQLRQTAAILRHELPQPGLGLWLLRRETLGATWRLFRQVRIDRQDLNGAQQPEFGEEYDPACGQGIPVHGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF73</accession>
    <name>A0A2G8SF73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_05473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF73"/>
    <dbReference type="STRING" id="1077348.A0A2G8SF73"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="17"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL32228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="530" mass="56756" checksum="FAB2C411D3B220B2" modified="2018-01-31" version="1">MPPSSPDSPKGSAFWLSFIAVIVANFLSALDMTAVSTAVPKMTNDLHGGDDFVWVGSAYGLASTAILPFSGRLADVFGRRPIMLTSIIIFLVGSALAGAAQTMSWLIAARTVQGIGGGAILNLGSIILSDLVSLAERGTYQGILILVWALAGAIGPTIAGSFAQDATWRWLFYLNLPLAGIAFVLVAVFLRVKTPEGSMRDKLARVDWLGNLIIISGTTLALLALTWGGIRFPWNSSHVLAPLILGIALMLGFFVFEKLVPLEPTTPLDVLQNRTALSGYIATFFHGIVTMSTMFYLPVYFQACFGSSPIHSSVNMLATTLICAPVSLFAGGIVKKVAKYRGANYAGWVLMVIGFGLFTLFKYNSSTGMWAGFQVITAAGIGIIWSATVFPILASIPVHRFAAALAFQNFLRQFAQTWGITISASILQNELKKHLPPAFAAQFPQGVEIAYALIPIIPTLEDPLRTEVRIAFATSMSVVWKAMLGISAGGLLTTFLLKEIPMHTAKDNRYGLESSDSDLVGPADAEKGHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SG61</accession>
    <name>A0A2G8SG61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SG61"/>
    <dbReference type="OrthoDB" id="5599874at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld7 C-terminal" evidence="2">
        <location>
            <begin position="331"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="403" mass="43097" checksum="CD05FD56E6B590F7" modified="2018-01-31" version="1">MESTPSKALAAPHRLLYRGSLSLPDSYLLLDGLSFTVDTAQSHGSPALLNNTLALTLESLRGLPLHLIGTVRVKDVWIEPPPADISIDIHPDSTSTRIYFENLFCINPITSKDRRSEYGIRVSLTDNDDPETPDLIIYAELRPSPPSSSACAPTSSPSPATASTSHSPPHTLHLLAARILPGPPPLPSFRLPRPDDPTPRRPPLAFGGAGAGAGAKRKRESVKFDLSAAQAAGEGGASKRARDAKGKGPAIVTGLLGMDAKALGKHARVGVGKGREGDVFKVPSVPVSRTVSEADVFGRGAGSGKGKEKERAKARDGEKEEQKGEGEGVERENKNVVKRAVINALAREGIEKTHGEFKDFYSPMYHGVCLALRRRMTTGPLDGSLVEHFVDAHLQMYLKDAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGC8</accession>
    <name>A0A2G8SGC8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">GSI_04947</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGC8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGC8"/>
    <dbReference type="OrthoDB" id="2756640at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PIL32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="72355" checksum="F20365F64C6B077B" modified="2018-01-31" version="1">MCQLVTASAYLGSSDTAHALLEAFCLAMAMHPDKQKKAPEELNAVIGPHRLPDFSDRDALPYTRAILKEEMRWHIIAPIRFIHLTMDDDKYNGYFLPARTILNTNIWLVQLREGYPDRESFRLERLLEDGPPSDPADYVFGFGPRLCPGRHFSIASSFITFTSVLRIFDIQPPPTSIWDPNQHGKEAIRTSSKPYLAKLIGLRPALGCNLKMSRQFPNELFDAIISCVPTGHTGWLWPKERETLLNCTLVCRDWLPVSRHTLFSYVHLKRPTAWDSFLRSVVNAEEGRPWLASILRLQVEDGWYSHYEGDKKIPAKPVSEWRGQYVIPVLAGHLPNLELLSLSVDWDRCQPHATTFGMFSQFTSLRELRLDSCRFPSFCTFRRILVSLPALKTLRCSAVHWPSAPQPSILAIPSGHLALQSLGISLLCDSFHDLSLQCGPVDFHPITLPHRTLDYYVQIFAPSVQVAAFGNIQSMHDIANTISDLSRFGNLRSLDFAVNGTDWGDAADLLQSLPARLDTLIIFVDYGRELVDRDMMVKEDGEVKAMKTNGLELLEPVLLRDNFKALHHLEFKPWGYRDTLEPLEESIIQTIWRKLPKLHSRTTLNIRLAPVYINRSPPPSRRPSPSPAVEIISGGFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGE0</accession>
    <name>A0A2G8SGE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04962</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000009">
        <property type="protein sequence ID" value="PIL32845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGE0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGE0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL32845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="301" mass="32829" checksum="7324A1082C2591C6" modified="2018-01-31" version="1">MIAQPALIDAVSTLLTAQYYTFATFAFVTYDWLINLDEEIRCFWDFSKGCRFTAAAVLYGLSRYPPIILIILQLRTIFPMSDKAYVVRPTETIVLSIIPFSLTPAIFSAIRVYTLSPERKITAVATFLILFVPAFIISTLNATDTPEVLPSPFNCTNNPAPHSLKRSILARSGAPSVLALGNLATYASPPLTAILICRFLFDLRQADRTTAAASSPSGMQSLNLDLDFNVSVHSQGHRSSTLPAFVASMGEPVYTGIRFVDEIRESEGVPTTNNGGERNEGCSRARDRDELCGGDMGPASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHJ4</accession>
    <name>A0A2G8SHJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHJ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHJ4"/>
    <dbReference type="OrthoDB" id="3261594at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="455" mass="50764" checksum="07ACD2E0152B2E57" modified="2018-01-31" version="1">MPDISDPGSTEAAESVVPQAEGATDLQDCDGYESLLDGGQVQVDSEPQGSIAPRAEIAAMLGLGLEDPSVFREVESDVARQFSALDLEELDAPLPHAAALEDLSLHHNDESPGYIPPRKTGIPTIDMSQIFVDRLRDNPSLEDSRLDSDTINHLLWEPPTELAKLSADDRLSIKLFLADTNGSEKIYKETRKAVLEHHPNDPILSHHSVKKKVAELTGIYPLTYDMCPKSCMAYTGPWEGLDRCKFCSEPRYDQDLLAQAKPVKKAHRMSDTYPIGPQVQARFRSPEGAQDMRHQQGEMGRIMRELEETEGELDRISDIIKGSDFWDAFQRGQISEDDLCLVFSMDDAQLYEHKASNVWIYIWILVDVSPGKRYKKKFILPGTIIPGPMKPKHADSFLFPGFHHVAALQCTGFWIWDAARKVKYVSRPWIVLGEADAVGAPDQTGYVAHHGKMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHR6</accession>
    <name>A0A2G8SHR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHR6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHR6"/>
    <dbReference type="OrthoDB" id="441812at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34025" checksum="CB1FA0145D4C95A8" modified="2018-01-31" version="1">MVPVADAFNHAHHNHVQLASEYDVCPACGSLSECAHDRQGGAIQVDREEDSGPVPPSIDSTDTVDMVTVCSVPPGVEVFNTYGATLGNAALLARYGFVLDGGETDTVTFGWPGSSLELELERGSQRWENAYTAARSSVDAVVSGSSLVYVPESDTERSLALSINSDGQVSVALFVWAVVDALPQEPPHVQADLVLRVCSALVRFETLRDADEDEDAPAQDRPHDPEAERVLIAAVGSLKWLCHNRAAHIGAEGYRGASLEALVEVLDNLPEDREKTRLALEYLLSERAILGACAAGWEDLERTIVPGAGSTTSDEDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI73</accession>
    <name>A0A2G8SI73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_04098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI73"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI73"/>
    <dbReference type="OrthoDB" id="2919105at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="23"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL33475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="445" mass="49178" checksum="AED6A2C9A892DA5C" modified="2018-01-31" version="1">MTAFLPLDATASFPSSPAFLVVSPDPVNHVKRVVQAIIKARRIVVVCGAGISVEAGIPDFRSSEGLFQSLKKDHPRLVSGEDMFDASVFGSEDTTSQFCQMIARLSQLSEEAEPTTFHRFLRVLDDRGRLLRVYTQNIDALEEKSGLSFGVPTEDSKKIKRASVSRKRKAPGHDAPTTEIADDTAQSTRPSTIRTPSLPAETPRCIPLHGTLQLMHCVACTHACRLRDYLDSLVSGIPPPCPQCTAFEQTRRLLGKRSRGIGKLRPSLVLYNEYHKDGEVVGDIVEKDLMGSSKGKGRAGVDLLLVVGTSLRVSGTKRLVREFSKAVRYQDTTMDEPLSLPASKITQSVHDPVMPTPSSRRTAGRDDGLPVRTICLNLEFPVPTREWEGVFDVWVRGDAQAFATLVFEELKKEELGQELAKERKRKREETIAESTRNTDRVVTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SI98</accession>
    <name>A0A2G8SI98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_04117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SI98"/>
    <dbReference type="STRING" id="1077348.A0A2G8SI98"/>
    <dbReference type="OrthoDB" id="3156807at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="128" mass="13722" checksum="7BF81B57E2F6FB9E" modified="2018-01-31" version="1">MCTQPILVAPPQTYLDYLRLPSVALAARTASLPEIDTGPVVLDGAASDTRLDQDDADAAPVAYPLVQLMKAALYLDNAEGTGRELSNGHFFNDDPRRLTGLNVEIPIYEMRMTASTSGGPSLPLFTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIG8</accession>
    <name>A0A2G8SIG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_04198</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIG8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIG8"/>
    <dbReference type="OrthoDB" id="2752444at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF24">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="10">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="11">
        <location>
            <begin position="522"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="755"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="674"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="768"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="804"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="916"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL33575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1088" mass="119959" checksum="37163C0A6B2366A0" modified="2018-01-31" version="1">MADIHQINPDPSSHTDSHSNVKIPTLIEDGSNWILYKAQFLTDVQSKGLRRYLEGRERLPKQPTAPGVDSDADERYETALDKWTGNHATIKSLLLQTVPESLKLDIATKTRADEAWQILTSKYDNQGDFMQLHCEEGADPRPVLTHLARLRSEYATAGGVLPDDQYKVHILAILPSSYRPAIRAIQASARSAQIPLTPTALIEAITEIAHDEHAMDGDATNPSAMAACNIECYNCHREGHTKAECWSKGGGREGQGLRRRGKGKGKDSRKGGASNKSGESANVAQGSVQAGTSDNSNTLHAYTFWEEESASISIDFSNVSAQRLPIDRFTRLLDSGASCHFEPCRENFLTFRNIEPIPIQSADGRTFHAPGEGDVRIALSYGTRGVNEFTLCRVLYAPSMPVSLISVSCLANAGFQVHFSQDGCHLTSPAGNLSHTIPARQGLYHIRGVEPVTTPQAPETAAATLSDLEFHCRMGHAYPPILRKMIADGAVTGVELDSTAETRFCEVCQQAKQARELFPKARSSPPPTRYGQRVHTDVWGKATVRTWDRKEYYITFLDDYSDEAVVSLMRNKSDALARYRAYEAWVKVHRGVTAIEELQSDRGGEYTGHEFTAHLESQGTVRRLTVHDSPQQNGKGERLNRTTAEHARALLFDARLPKFLWGEAVLHSTWCRNRTTSKNTPGSTPHKLATGEKPDLSQLPRFSATVWVHQEGVGKLDPKSKPGRWVGFDLESKGHRIYWPECRTVSVECNVRFEPEDGTTTTVGTQLEGEHIPDDDLRASTPPPQPNSEPNVQPNKTPSSSDPPSTPSISPPQPSEPSPPIVTPEPPNEPSPRSVPEPPRPKHGQAESSTPETTEQTGHPKRNRRPTQWIRDLQAGVGTMGGRGALRVPKSILGDSARTAVQHEDERELEGELSEESDHGQGEPEDHGGCADEAAVDGGAHHSKPSVFALAAMSSDDEPPYRDAMAGPDREKWREAMEEELDRIAQMDTYELVEAPPGANVVSSVWALRKKRDENNIVTKFKARLCAQGFSQIPGVDFDKTASLTARPSSFRLVLALANANDWEIHQIDFKNAYLNGDLDETIYMRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIM0</accession>
    <name>A0A2G8SIM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_04190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIM0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIM0"/>
    <dbReference type="OrthoDB" id="2742526at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="234"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL33567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="643" mass="72951" checksum="0DB2399C780262C3" modified="2018-01-31" version="1">MWLLSTDRAELRAFSGPEDPEILGGYAILSHTWGKDEQTFKDTQALYAQCKGTDKNPRDLSTRKVRESCVLAEHHGFRWIWNDTCCIDKRNSTELSEAIKSMFRWYSLAEVCFAHLVDVPSDCDLRARGSAFWNARWHTRGWTLQELIAPSLVVFVSQDWQRIGTKTELAQLLEKVTGVWAKVLTGEVHYTSLCVARRMLWASRRSTKRIEDEAYCLMGLFDVHMPTIYGEGRNAFQRLQHEIMKQSFDTSLFAWGRCNSLKNMEPVEPDENRRFFNTPSEEGMYALARSPKSFSTRPFGRFVRYTPAAKSPTQRYPPDPIREFDPEGRPLGPFGPIKLPRFLSTSYGLECHFPIIESDGLTVAVLLCDTGSDHLGLLLHPSSDRVQDRSRKKYYTGCGLRKQPSPGAPGSNSNSSCGYPRREFARLISLGDDYWNLHLNGKAVTAEWRDVFIAEGPPPARRDVPPTLYSALHSTAPAPPFRIPSALVMRLTALGMEPRRMRMESMPADRKPLLASATFEDAGAREGVRLVLGTCLQPQDRGPPMHWAKAVQRWSANWSQWPNYDHDCMEDHVDGWPDLTKDFGDGERAIRLSFWRCSLNPAHTLVVHIELGGRLYDALKDQRGVAFPSREDVRLGMPPNSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIQ5</accession>
    <name>A0A2G8SIQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_04253</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIQ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIQ5"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14829">
        <property type="entry name" value="Zeta-COP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="8"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="185" mass="20841" checksum="D88730FCCC83A400" modified="2018-01-31" version="1">MNLSLYTVAAFLITDTDGHRVLAKYYHPKGHPNGESKKLTTLKEQRAFEKGLFQKTKKAGGDIILYDSHLAVYKHSLDLIFYIIGDPAENELMLHSALVAFSDAVHMLLRNQVEKRGVLENLDLVLLCLDETIDDGIIVETDSTTIASRVSRPRADTTEIVINEQTILNAYQTVKEKMQQRIGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SJC9</accession>
    <name>A0A2G8SJC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_03579</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL33873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SJC9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SJC9"/>
    <dbReference type="OrthoDB" id="2747824at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL33873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="515" mass="56277" checksum="54BB6D04BA0184F0" modified="2018-01-31" version="1">MLCRAIRDLIDNTVELQYKLALARAGRVEVGQSKLCIADRLRALENLCTNGFSLPTVPFIMLPDDIDPRWPAVTDGFIPYLANNSSDLVLWRPTFPSEDAPEERRDVPAVMSHLSTPPQVPEAKMGTLAVDVAQGLLVFTRAAQPDISTPECYVYSISEGRPHSAAGPGPLRIDFEPVFVEDGFNTIEDLQIFGDVVAWSITDDTHSAVYVWNWKTSVLVWHRQSDARGSSCRVISPCHVVLVTAQAVSVYSFDSSEDAERPQEPGASLADPLCVLALPALKPAPYPPYVRTYMQFPPSAPTPAPQSNGDPGVAFGLDPALTVLTITLLLSTVDKHNLVGSDYRYAIFVPLSTLREHIDAAAHSDADTDADVGVDAGRRTVPVPWAEWGPPGTRIVRFSAISHISAMGSRCAFMRQEQGPSGELHVVLFDVRRGAGNDRDVESLFDELFDAREGLGPTLSFVEEIRTTFPVDVEYSVYGSMLSGYLLQDAVAMSSQAWGTQGGLGWQWPGFESWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKI0</accession>
    <name>A0A2G8SKI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKI0"/>
    <dbReference type="OrthoDB" id="3240777at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="166" mass="19011" checksum="4819C61824C97821" modified="2018-01-31" version="1">MSSKISHQRVINRVMNDMAPQVIEAVQVAFAERPDQKEIVAIPTVNSFCCFVYFSRGMVPPLDPAMANQGKGFQDPTGRTGRRLYDKYGKRYTQTIQIMYGGGDFFDKTDVKTNRQASGAGERKILKFGDAFVVHWNNFIRWTRGRDLFPDPEDDEDEEDDEEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL95</accession>
    <name>A0A2G8SL95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL95"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013943391" description="Transporter" evidence="1">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6421" checksum="E54F3FA5E5BCF8D7" modified="2018-01-31" version="1">MPSTRFFLLAVLLVFFAALAVDAAPIPTEDADHEVIDAVWLSVNQRSSESASEDASGVGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLH0</accession>
    <name>A0A2G8SLH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Reverse transcriptase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_03369</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SLH0"/>
    <dbReference type="OrthoDB" id="2801433at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="11">
        <location>
            <begin position="606"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="1171"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="12">
        <location>
            <begin position="2790"/>
            <end position="2953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1368"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1504"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1586"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1652"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1701"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2191"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2578"/>
            <end position="2600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2647"/>
            <end position="2670"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1443"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1368"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1394"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1416"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1587"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="2239"/>
            <end position="2250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL34590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3038" mass="339363" checksum="30F2E139C8BCCC35" modified="2018-01-31" version="1">MSSSDASDAQVIFIPKSTPNIADGHVTPAVANTFKHGCVVHFKDKDVPLGRQVAKATANITNALISDWYIARHEEFDAMTFEEFMAEFRDQWLPRSWAMKLRTQILQASQSRQEPFDLFCIRVMKLNTQLHGSNLRFDDNGLRVTISANLYPDLAVQANEYAVTSIVSFKDWQDAVNELDIACRCIDAQVLSLIATNSKAAPKQKASNSFIRVKDAPKPKLPKLTDLEYTYLRAVKGCFKCHKDVDAAHTSANCPNGYPDAATYTTCIPKGWKPSDKENKKPTSHSVNALNAAEGLEDANVVVAIDALTASTGVLGSGSDSETYVPPLLAPHTILHARIIAPETYSDVLPMLADSAAPTVLIRQSLAVSLKLPLQKLPSPFKFSTAWGSGQRESSEWVKLAVMLKDYSWSSQVVRAIVIDSLCTPVILGKLFLQSNCLVEDFAACTLTDKRCGHNLLALPSPPPPPPLSTADRHKLQSTAVEERVAVKDASRIRHRHFLRELESSTCRRHIAADNSAPDPAPFIIAAVQTWVESLASQDRLRAENVSMKLWFADLFPDDIPHIDCLPTDVCHRFVLKDANMVIAHRQYDCPKKWRDTWKTLLEQHLAAGRLCPSDSLYASPAFLVPKTDPTALPRWVNDYRVKDANTVPDMYPLPRISDILADCAKGTIWGKIDMTNAYFQTRVHPDDIKYTAVTTPFGLYEWTVMPQGCHNAPSTHQCRMYNALHPFLGKFCHVYLDNIIIWSQSLDEHRRNVETVLQALHEASLFCSDKKTDLFLTELHFLGHIISSAGIQADPSKVEKILNWPVPRNARAVRAFLGLVRYVANFLPNLADHTVCLTPLTTKEAEASFPEWTSVHQRAFDAIKQLVVSRECLTVIDHDDLERNMIFVSCDASDLRTGTLLSFGLSLDQARPVAFNSAQLKGAELNYPVHEKELLVIVRALKKWCVDLLGVPFEIYTDHRTLENFHRQKDLSRRQARRQEFLSQYDFTIQYIKGEDNVAADALSHIDVAALPVEPSSVTIASTLLNATTVLAACAVDLATESAPHSSPIRFSLHTDTAWLDAIRAGYAKDKFCLRLRSLAGTLGVCEQDDLLYIGDCLVIPRVPHLREGIFCCAHDALSHFGFEKSYANLRDTYYWPHMRKELEMLYIPSCEECQRNKSLTRKPTGPLHPLPVPDARASSIAIDFVGPLPEDEGFNCLATITDRLGSDYRLVPCRMDTTAEQFAVLFFDHWFCENGLPMEIVSDRDKLFMSRLWDALHKLTGIKLKLSTAFHPQTDGSSERMNKTVAQALRYHVSRSQRGWVRAPPQVCFVIMNTVNASTGFSPFQLHLGRSPRLIPPIVDQPLPSSHADAEVTALARSIIHYGKKAKEEQCQHSLKENGRPSTAREAALKPLEGRSPGRHEERSVRSHLLGVPRGHDPGSDRSGRSSRASDNLRMNVEEFAEDTQVKYDMLADELARVQAKQDLLNSELEGIRARQAAEHAKFARMAECVQEDIAKAGYPAGNSASQNNLFRSRDGDETSTAYGNRINAQTRFLAQEHYRQGAEKRNAKVEQWWRERTGDTGNDRVKTDLNHLAGLIEESRRFHTPSLTSLSTPSSPTPRSRTDRLVSPFEFLPPAFRQRSYSDSFFAVSSARWRRELRALGVAEENFPTELDSQEVAPEDDTFGSALSPDSETELALPGSLPSPPVRVSNLASAVQSLPTTTAPSASRLPTPDPTARPVKVEQEEPTPLTGPVARAPSIAFVSVAPAPVIPPSFSTTTATPQVVPASISKMAQAAKQTMPVRGEKTCPKFDEADPTSLHRYFDDLEALFVRHSMPDADQDDWKVRKELAVRYPPAAVEYGWKSLPEFTEVTKNYTDFQDAVYALYPGVTKDREFTTTDVHRAIDEQLRVKYINDVNDYSRYYVKLRPMLANLLKKSRITNLEANQFLADALDPSLKPLITTRLLHAYSNRTADTPYTVEQFHQSTVYVFLHRNDDAEAIFRSPGSSSRTVGTPVAPAPVPVPATAPAPPIPQALPPIKQEDVKSLALLLQQQIAENWHNQGPPRDHPPHMRGGFGGYGGGPNYGRHPMRCYYCGKENCDTKTCPEVMDDIRAHKIRRERNQIVLYDGSPLHVGFNGQTMREQVNTYCDRNAHTAPRPVDHMLLEIVPNAPECESQSLDYESAVQFHLAEAERLRNERSRNLKFDGVVIPQRMNRGPPRRVAPTSARAVDQARGTSPSAPAAPPPAQPVAPLAASPVVPPPAPSAPPPAAPVHPYANVRPVNDAPLATRPIAPFRAVAPGHIDPATVIRAPVAVATADDRVYNRAVESMPFVTLTLDELIGIRRFVWEHLLVANRIIRRIAHAGGTFSGPKAWPCIDERVLVGSRCTPIGRLPERERVDAIRNWRPCTTLSEVRAFLGTVGVARIFIRDFAKRANALTMLTRKDVPFEFGPAQLAAFDDLKTALLDCPALRPLRYDSDAPIILGVDTSFIAVGYLLCQQDEEDPKIRYYNRFGSITLNARESRFSQLKLELYGLFRALSALKLRLLGIRNLVVETDAGYIKGMLANPDLQPSASMNRWIMGILTFHFELVHVPGKKHAPDGLSRRPPQPGDKPEPPPDEFEDWLENLYSFVHIINPTPRLPSASIPPSPDTVDMFALGLVPQARPPDIEPPPYSNFPRTAHARRSDAQLSRVRDFLDDPKRPAGLDERQWIAFYKYATLFMLDSAGKLWRRKEGGAHRLVIPEERRPSILVEMHDRTGHRGLFATRAFVCDRFWWPQMGSDIDWYVRTCHMCQIRQVVRIHIPPIVPEPTAPMVRIHADSMHMPGRYKYFAHARCTTTSWVEGRALLSETARTLGEWLFQDIICRWNALSEIVTDNGAPWVAACTYLADKYHLHHIRVSGYNSQANGIVERPHFNVRDALFKATEGDGAHWHSSVHTVLWADRTSVRRRLGCSPFFAVTGSHPILPLDFKEATYLVGPPEGILTTEELIALRAIALQKRADDVDRLRSAVYAQRLQEAEDFESRNCATTRDFDAQPGSLVLIRNTAIEKSLGNSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM05</accession>
    <name>A0A2G8SM05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_02540</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM05"/>
    <dbReference type="STRING" id="1077348.A0A2G8SM05"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="51"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL34753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="775" mass="82711" checksum="3C0F0ECD9C42845C" modified="2018-01-31" version="1">MPLPRKTQLQDAPRWKGKERDVSGRDEGDGASDGIVIDLTLITDSQYQSTYVAPIFLGQGLSKHYVQVDTGSSDLWLASTACSSSTCNAVSGERYDPSASQPTGQSIQITYAEGEADGPIVWDAVQLGGYSIDHQALIAASTVNNEPLSSQFNGVMGLALSSNSVIARQLPTATNDVPDGATLSSNLFSITPLGTAPGARFFSLTLERPGSDRVPSVLGIGRHPESLITDPSKIQYAPVSPSGYGTLFWQASITAITVYVDGQPKPVSLPTSVVPAAKAPSAILDSGVPLIVTTTEIANGIYGAMGVGPANDGNYYIPCTTPLNVSFVLDSRSELFLHPLDLTTYPPNDASSETCIGLIQTPASLPGLNFGTTADMVLGVPFLRNAYFVMAYDPPFPNGTFPSNSVNSYSVDAVRPRLGLLNITNPVTAADEFHQVRVLKSPLNNSHAPATSHSKGLSVGVEVLIGLLGFFGLCAVLFASRWVYMRRKYKRERAATAAFNGDYKDPAYVMSALGYKPRPGEPTEDELRQRRFEAYKRRHMNSQYTDDTVLTRVEDTPYDKGGATDEFGALKVPPTPGTPLADYFDPWGDTLVTSPTPDDPQTPLASLLPPPRTARRSLSPRSAHHRTFSGGPSPDVPLLAHTRMDSNQSVHLRDSDIAEFGFGTELPPTPNSMAGIGRRRFSSLGGSTLGSPHEEHEYFSPRTPSYYSSHARTGSAASASVSASVNPRESQSLSPLSTPSVAVPLPAIAVEPAVAEYVMDTSLNNSRASVIGHES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMG1</accession>
    <name>A0A2G8SMG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMG1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMG1"/>
    <dbReference type="OrthoDB" id="2757285at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="657" mass="72158" checksum="0405D5814393C9B8" modified="2018-01-31" version="1">MTTLDVTQPLQHCVPRANRLGICDLPDDVLILVFSSLYGQDVARCIPVCRRVSDLIHGNLSLQYSLELAINGMVDGEYNTLPMSDRLQRLRQYSSDFKSGAFHRQDLTAHSDYLRQDREQIPWPRRLIVGPKPSGAITTKADGVDSVLYLSHFIPGSAQGGIPSNRSLFSVRDALRRDLVVEGWAVDDAQDLLVMVEATRTLMPPVVDWVPDVYIHLHTLSDLKIDSTVLTPHSAAALPSIHLHTFDSAKLSIVGRLQTFGSYVMLEIVAEVGVKQWYNFIDVYNWNTGEIVSRTNLGKLNVSVMPLSERYLLVFPFNLWPEHHPDLRIYDFAPSPSLPPQTGESQAAATANVRAGHHVCTLELPPAPPGERVTWSQAKTGDRRAEESTGHFRTDMTRSVVTLSIQYESVKLYRNPYDDGYDAMIGQEDEDEPAYAYTTHLLIPQATLTAQIQAAESASAARQTRMGDDAGVGNADSPTQHAPAPLAPSVTVPWADWGPRGSLRLYQRGAFFNSARVSVPAPFGSRLPFVVESDSGRAESAGTGSVYVFDVNPLVARSTLRAHRDRRGSAAAPTAVVDTEDVEKVLPGVVDPECAAVPYVVYRFPLPYPSPPASSETPPGSPVGPPEIRAVTMSMAGFTVEFDESVEYEKRSQTCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN22</accession>
    <name>A0A2G8SN22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN22"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN22"/>
    <dbReference type="OrthoDB" id="3363891at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="710" mass="77341" checksum="07A6113F46B02BE2" modified="2018-01-31" version="1">MALTATAQSALPREPIWDEVIVPALRKRLKDESTVLTKRMSAASVTSSEDQAISQYHPRPGTSTSSHSHSNSKPSAIPRPSIQSSRTTESSAGVYAGAPPPSFQRARALSQPFPFEPPLHADQAPPVAETRSISPINAPKGTRIPVSRTRTGSTSSQAQSTYTSSGTTGRVNGYARHNGDASESQLYRVEEKTHPPAQSPPQSHTSRSTIQVPRRKVSDIFQEQAPFPNSLSSSHSQLDYAPERMSSESDERPFEHWYRGDVARNGGVGELRVARRQEMLDIANYGHTLRNAASKSQSGASSRSRSNSRGRDMPNGRAKGRPRADSVGARESIYIDEDAMEDGDAVMDERPLTDLDDDDDDYQGYEDQLDDYYTQTVQPHTNGSVSSPSLERSDTPTSRLTQNTTRSRIPQPTSRSRTTTPTPTLGKPTRSVSENALSGPSSPSVPSMQRSATQPLKTQGSPSPSSLPANPSAPSTPTAKKRAKSPASSTPSTSKKQKAKAPPSSMQKRPGAKDENRRSVGQYPLPDGDEHAIPTWTQPRQANGNWDEVVLPVVARKKGLQDQYETADGTPKPREPEPMVVEPAPGTFGYDPTKRRKRWSGNPAQILMDEFGQPKEFDPPEPQPLPRLEVPEPSPDEQRGSPTTPISSSPRSFERPRVVSPPPFSHYQTAQHLSPQMQTIRPMPPASKEELIQPPADEDGGAGCCKCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SPH7</accession>
    <name>A0A2G8SPH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 4, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytochrome c oxidase polypeptide IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">GSI_02407</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c oxidase subunit 5B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SPH7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SPH7"/>
    <dbReference type="OrthoDB" id="10249250at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00924">
        <property type="entry name" value="Cyt_c_Oxidase_Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.11.10:FF:000003">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.11.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit Vb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002124">
        <property type="entry name" value="Cyt_c_oxidase_su5b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036972">
        <property type="entry name" value="Cyt_c_oxidase_su5b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10122">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01215">
        <property type="entry name" value="COX5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57802">
        <property type="entry name" value="Rubredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51359">
        <property type="entry name" value="COX5B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602124-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PIL35677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="153" mass="16541" checksum="64115DCE579342ED" modified="2018-01-31" version="1">MFAAALRPASFAARAALKPARTAAVRLISSTAARHSDVPTPQIYGEGAKAGQVPTDENQSTGLERLQVLGAIEGVEIFDSKPLDASRIGTLADPIKVFSTEPLRVIGCTGSPADSHELLWMNLTREKNRRCPECGSVYTLDFQGEEHAHEHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR94</accession>
    <name>A0A2G8SR94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_01950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR94"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR94"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="236"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="343"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="236"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="498" mass="54483" checksum="3E534B344C849241" modified="2018-01-31" version="1">MLHMSMPYQVSATNRNLPRRSDSLLKVPTTTIPYFSELDDELRDIRRVHSQGQEEDLRYALSRTINRIEELTSMLKEAYKAQTDLQTELTLAKSNLTMALANNEMLEDALKRDHPSHSKDVGWRRMSAREQSLRVESEAERRRSTDSLATDLSSSPTPSQPPSAVEHSPVVPRSATMPSPAPPSSTTESRFFRFRFGNGSSSASRPSSPRLSAGQSPMLNGSHLTSASLPSLVPPKEDKEKEVEELQHQLEVERKARKDAADAKVALEAEIESLSQALFEEANKMVATERMKLAETEEQLREAREQGEALKNVLRLFERDTEAARTRTHVVDRILEDDTISFRSRRHRASSSAVGIKSPSSGIPSPQQSRSTTPSHSPSDVPSSARTVVAGPSSSPSTPPPKDTDESTDRHDLPGAKLAVSVSTDSESSTLSTSTTLRISPSPPPTSSPHSPSHIPSPLTAPGQFLFTPARAVSYFDGEESPWADATSASTTSPKVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRE5</accession>
    <name>A0A2G8SRE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRE5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="220" mass="23784" checksum="C558750CDCC4C5B0" modified="2018-01-31" version="1">MAMAMACATASAGPCRRRPAVSPHSPASDSGLRSGGRAPHRSLRGIQCSPRTACAIAGRPVPTAHRAMRPPAPARRRHTVAPSPAYVIVVRPAEMLGEHQVSRLSVKPGAADFDFSGSRPRVRGPRPCILAPCAPEFPRSAPLCARRWDRPFACVANTLCAKRIPLRVKQFQLYLPGGVESLADQNPTTARGAAGYMRFILEFWQISTSLCSPFSVEKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SS20</accession>
    <name>A0A2G8SS20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SS20"/>
    <dbReference type="OrthoDB" id="2752849at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="474" mass="52255" checksum="2CE5152EAE5FB8BF" modified="2018-01-31" version="1">MFPEGPHSTQFVEERNEDRRTILEDLLSDALGSPVFDCIATFSPPSTPSRQPQMVSPPSFTLVQDQPKHKSPQYSTTPDSIRELRSSVDSRQPSMDRDRKLSPALPSPLRTPSPVASPRSGTHFYKDFVQAPPAPPRDVFDAYPEDGPQSASIHQQPSKHRKSWRTTSSASSSSKDDFVCDDRDTSDFTYSQASQQNSFGAGNLPHASSRRATEGSFASLTSSDSRRRKFAVRRQAIYAEYGFKLAFPDSDSSSSIRHTHVPTSSSRDFLETGSSRATSAYVESRSVWSASTSAASIRSQMQHDAESADDDDGDDKLEDSEHSIIPYPSARSLANLSNVERFSVQDSFLSSSRNPLLDEHADLMTSTPPAKPRSQIQHPASLKRITQLTPLPAAEVSLPVANAEGYTCGLEWQPWPPLRVPGTDSENGGSIIRRSPSTLERAQMFAKWQDDPGHHPIIQELLNAVDLAIREWGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSH7</accession>
    <name>A0A2G8SSH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSH7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSH7"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="158"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="478" mass="48775" checksum="DD3BD463CE396EA3" modified="2018-01-31" version="1">MSECYQATFRWPHRDASNVIITGSFDGWSCSRYLTKSNSGFFEGIVQIPWGEKVAYKYIVDGRWATTDDRPTEMDNEGNLNNVYRAPARPESPFKPTPAPAAPVKEPKAPTGPTETGATEGSSVAVVGAVGAVTAAVAGVVETAKQAAVDMVEAMAPGTTDTPAATPVVETPQPAPTPAPAPEATQVSEAAPAPAPTHVSEPTPPPVPEPSQPGAVAPDTTAAILPSGPTPVAPIVPVAILPLGTEPASESVTAPLANVSKSKPLAVVEGTSTADGSSPPAPAPAPETAPSTHVPAPASATVDEKPSADLAGPSEEKSTTNGTEHSEDKHAVNGTPAVNGTDAPKSATTDGTTPATTDSTPKPEAAPVNGAEQAAPHVNGKTTTTATATTPTKEKKMRFPSLSSRSSKHSRTRSSAEATSASTSPNHGASELGERTANGDGKDTVSSRFTASQRQKRTSIFGKLKDVFSHHKNEPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SST2</accession>
    <name>A0A2G8SST2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SST2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SST2"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="16"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL36814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="144" mass="16147" checksum="2A89D5A819CF8BBE" modified="2018-01-31" version="1">MSDHEAGGMPSDEDLSLPKATVTKMIAELLPNEITCAKETRDLIIECCVEFIHLISSEANEICEQESKKTIAPEHIITALKRLGFESFTTEVESVLKDHKQQQKDREKKVSKLESSGLTEAELLAQQEALFAQSREKFRTAAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SST6</accession>
    <name>A0A2G8SST6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SST6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SST6"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN / WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47232:SF1">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN _ WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="952" mass="104003" checksum="396016C89D92545F" modified="2018-01-31" version="1">MNVSGKRPASPLPRSFDDIVRPRILDVKKDKRPSTQTPLSDRSVEHGQEVLSFSVSLQHDLSHENINDLILGTTIRLAKEGKRLVKAPRLLSDGIAFDWTYDATACGENVKSLLSVEGIHAQDLERVLLRATPAFGGENSSPAAEERIPLDDILVGAACSQTPRTPNIGSAADPIMVDDDEEGTDGSMFHPIVSISEPSQVQNIAKDSRQDTDYLATYRMTPFKPRSSIPTDVNAAVPSGPQQADLLPLQGIHSGRRPDRELSTTRHTFRGAEPPPSGDVIQEDLSIATLDGDEEPNASVHSSPRFRQLSHYPSAAGPGKRRADYGEWKYLAEDSSDVEMELADHPSSRESSLTRSAPPQETTHGVAGLPFLPRTYDTSGLVSRQFPALASSSSRSGAGSSGSESASQRDRSSRERLYSRRPADTPRRRPHQRLDHDAEQSDENERAESAVFRPHRRLQAVDGVQLGAGNSIDLSENGSDFDVRDKVQKPAVSHRQQRSSRASTNLRKAQPSGSGRVPQHRRGASDRPIRSTRRSASPASGVATSSSEDAQDTGHQASLSSSTSPGHTVVIPKADFARGRRLLVPADPDYPITAILMRGEAHFIDQPRKTRIYRHSLPVEDDFRHVEDACLLRNDTVVIGYDKGPCQVSLITVEGDQRPCRVDLNHKAHSTVIENRSAGRAYPNRGIACLAPVAADRFLSGGHDKYVYHWKLERANHRGKNRGGYWATSERIPTEHSQPVQALAFCAWNEMVYSAAGDRVSMTNLGAIAAADPERVSGKVTQVHVHPQDPRLIALEVDHLDYQVHFYDMREGGFGRRPWLEFGYRSALPKATRASSSLSAPQPDQQGAGSSLSVFASASANGSTSRSASSTIVPKSGSRYTRGSTTNSLFARGYSDGTVLVWDYRNGAQKKVLERFQFRRPAEVVHTVLAGTDVIAYGGYSVTFWSTLATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST37</accession>
    <name>A0A2G8ST37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_00563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST37"/>
    <dbReference type="STRING" id="1077348.A0A2G8ST37"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL36873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="27732" checksum="600AB50C145F603E" modified="2018-01-31" version="1">MSSTRAATSDSIPPTARAISLLVAAIPGVQDTQSGVLHQLLEFSNRYTAQVLSDALVYAEHAGRSGKVEMEDVVLAVQARVGWEFGGRVPKEYMLSLATQTNSVPLPSVPEVYGVRLPPAHECLIAVDFDLVPNKPPPGVKLYDEEVEEVEESESDEDEDMEPAPLPTSQSQSQAQQVQIPPVSAGPAHTPSDVDMLTPGGVPAEEGSEAEEDDGLFAGGDEEEEESGDDAMEDVTASTPAAGDATTNGVKRKLVEEEDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STU2</accession>
    <name>A0A2G8STU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STU2"/>
    <dbReference type="STRING" id="1077348.A0A2G8STU2"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="516" mass="57523" checksum="71471FBB2C06B444" modified="2018-01-31" version="1">MPQDTGDCSVDTQSVLFGQVTEYIVTHPGRSQYSQTGGGVSACGLAALNCARIVLGLQSAGLDPAHLVQELMKRKFLEGILQPCLSWSSPSHLAVDEIYKVPIFQKCLQMVSSDYGQAGLPYFERLVSNIAGYTKSHSASTCVIITRPPEIIACFCLADVPSELFVIFDSHPRPEKHPQGAAFIFKNSIRSTAEYLSELLRYDERLLSDSTVQWQAQLLAHCSGDIFVARANGPTSSQWAEIALDASLEVLKLRARVRSLETDNESLESDKRQLNDEISKLDDKVLELDDELVRLKAKHERLRSSKHHNAGSSTHSFTSTRSQVAQTPLGTPSTRTEVSASNAPSNRRAAQVQPMSHASNYHASDAFAMELQRAFDAENRQLKQQMKRLRETQPAFFDCELDDAAVQQLGLNEKQYEIFNEMQMARFSTIIHCRKCLNTIFVDKGEYQEVQEIVCPLPGCGYAWCKLCSQAIEIGGPKHSCDGTSELNHLMRQRGWKHCPGEHLAFLDVDNSRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU31</accession>
    <name>A0A2G8SU31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU31"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU31"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL37242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="223" mass="25392" checksum="8FB2B0A4D021BB37" modified="2018-01-31" version="1">MQLARASRFHRYPEEPGSPPPQRTVDSQKRRYAVIVKGLNPRTCWQELKDFGRSIDCEVAYCDVDREHRTRGFINYFSEEDAEQAVRKLDGRELLGNVVRVQRQRPLASGSDQSHSPERARTSVETRSPSRPRQDQGMGYIPDQGEGPSYRVQSEYHSREAGGSSRHPAFSGTFYMPPYTPSMGGYPALFPDRTLPHEYAMASQQNTPSQNQGQGNSPSWHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU45</accession>
    <name>A0A2G8SU45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SU45"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="498"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="944"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="904"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1489" mass="167033" checksum="93242C0DD762E632" modified="2018-01-31" version="1">MSQSSDLRREHFPAFLHLFVSHMLFVRHLDLKERARPRLFLSSKLLGLLTCEFLPTAFLALEHVASASDLDGRVFAALLDSILTDHATSLSVFIGPELATTVDDLWRKHGLPSPDYAALRRQFTAPTLAQEEAEAEHFPFQLLPFKHPLFNGELAAINIAAEELSSDEEEESDEDASASHLEFNTRFDDTQHWHNHKRAILPSHLGGNDSIAPVNEWQRKRQLRSEQRFMSKLQWQAETLTGALGTPLQQMVIPSAAMARKSRMASPTKAGDPKPAKPAKGSAGRKGKKETLSSADKIRLANQAKKQAKEDDSNVAWWQEQLSSLEDRPTTNKITAVEHLMRNKRTKEGWLSIESRLYRIHLEFLRWMETLDRESQSVRDGFTVSIMCMVKDLYESKELFPTAAMKLASCLISLGLDDYIESFENAATVSGEDRKLNFDFVKLAKSKSGHAVNKWMRITEPSVVWQLRLFGEYMDRSMDSSSDPRVSFKPDAWQKKVLDCLDRNESVLVAAPTSAGKTFISYYAMEKVLRSSDDDILVYVAPTKALVSQIAAEVYARFRKELGSKACWAIHTRDYRVHNPQNCQILVTVPEMLATMLLSPPLARSWTPRIKRIILDEIHTIGQQEGGAVWEQIILLAPCPLIGLSATIGEPEKFNAWLASVQDAHGFKHTFIRHPHRYSHLRKYTYMLQGKDKTTTFQNLSQYSKSDRMRFVHPISMLSFGARRLPPDFSLEAADCLTLYHALESVREMLDFEVGALNPKVFFADCKGALLTQRDLLRYEAALTTHVSNLIDSTDPQDQNSILSQIIHELSDPLVATADESFVPSADAFFQNLITLVSDLHTSGDLPALLFNFDRKVCEKMATAILEVLEGTETNWRETNAEWNRKVRQWEIWVSKAKERERQAERLKKAKKDEDGPTPDAQPETRWEASFNPEDPSPQFSFAGLSPAFTKEDLEDELQGLARWKSAPEWALKCLRRGIGVHHSGMNKHYRTLVESLYRAGYLRVVIATGTLALGINAPTKTSVFCGDSPFLTALMYRQCAGRAGRRGFDLLGKVVFYGLPMDRCQRLVLSKLPSLGGNFPLTSTMVLRLFNLLQGSNDAPVACNAIKSLLHLPHISFVSDVGRVQILHHIRFSIDYLRRAGLLDKDGNPINLFGVAAHLYYTEPSNLALVALLRHGVIHRISNQSSLITAKRDLMILLSHLFGRRYLPRAYASATYLATITRKSPSTVVLPPLSTDARKVLIEHEDHIKRVFTGYALAYVSQHAAELGQDMRLPFSGKSICPVSSTAPSTPLTLLLRDTAVTPVARSPFVATSGHGDNFSSVKELAVTSRQGLHLNEYVIPTMRQFTSVPGRDDEEFALNAYLLDFYTHGQTAALKAANGIRDGEMWYVLQEFTLTLKAIRTGLAQLLLKASVSENTGNEGHDDVDVASALDSGFASMDPAEADPDVEGSEHGEFKRPVGVSDRDWRVYEVVNGLAAEFDEKFRAMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV31</accession>
    <name>A0A2G8SV31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV31"/>
    <dbReference type="STRING" id="1077348.A0A2G8SV31"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="351" mass="38711" checksum="35C5C6C0140B361A" modified="2018-01-31" version="1">MNPRRRTTVHDLAALRLHRDGTRVANSDSNSSSRRAKYTIRDARGNWVAKDAGGLGTVKLRPAASQPEGEQDDDGGESELEVDGELMKEEGVLPKPDKGKGRARESGDEEEIAVNTRAGKRRRFDEDFSYLDPVTPHIPGGEDPHSHPAEADPGTFPVPSADLLKCLHYFATAYYTAMGQLYDASRESRKERKIRRGQKFKKTEAAGSSPLSVGKELDDAQGSSDEEDIEFEEDEEGEEDQEIAKDMYKLFDGSALMALGMLFQEHVAGLLEPNVPEGWDQEFALAERDRSAAEKRARRARQMWNQRHTVKGEGSEQPETESGGEGGEERSQVQEGIAVSDSDSSDSAADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RN00</accession>
    <name>A0A2G8RN00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_15588</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RN00"/>
    <dbReference type="STRING" id="1077348.A0A2G8RN00"/>
    <dbReference type="OrthoDB" id="3262706at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="8">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb1" evidence="7">
        <location>
            <begin position="124"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL22892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="176" mass="19904" checksum="2EB093FD49F94207" modified="2018-01-31" version="1">MRRPDNGTFIGHIENPPLTAEGENAPEELDDEFDVLRESLELGDGKFKLEISNLKEDNNIKQMVVAGSKGSFINILQMSVCVGQQSVEGKRIPFGFRHRILPHFTKDDFNLEAHWFVENSYLRGLTPQEFFFYAMAGREGLIDTAVKTVETGYIQRCLVKALEDVQVCYAAQSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNU5</accession>
    <name>A0A2G8RNU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNU5"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="65" mass="7162" checksum="CBFCAA58195DD985" modified="2018-01-31" version="1">MESRLNSTLTPSASKRLPEVVEMRSRILVARLTHLATFQSMSPSSPKMSMESMSPYEIASVSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RNZ4</accession>
    <name>A0A2G8RNZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RNZ4"/>
    <dbReference type="OrthoDB" id="2756263at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="395" mass="43443" checksum="5EC10F1C5FFF110E" modified="2018-01-31" version="1">MPAEHLGLCRTLLDDGETRCSVPVKPGRQSCPRHTSAYDASYKRYKDAENAAKDLRAAAQTKRGDVHTIPPEDVEPRIKRVSAYIKALESELQLRNEHDQRFIGNPDKGHLQRLDALEKQLTHHRDIVETLRARLRIQRLKPAGQPTPPKHRRRHRHTVSDPTPQPPAPSASRSFRRRSHGQPSQRRGGHGKSHSVQTGSVQGRKEHPIVLTGEGEGLVEEDDGLGHPIRPSALSFHVLEDSWVGGASGQGVEAEYQGGGVAERYEDEGCQEEPTQCEEDRPILTASCLPVGATNASPPSPSRREPTNEDGSSLQECSENGDTSTRCPVPPSPLPWIVGEYPGANPEHVEEGNEAQLGAAHRGGYLKYAFAAILPATMIVLIRMFTTIRGRTSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RP56</accession>
    <name>A0A2G8RP56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RP56"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="122" mass="13086" checksum="D6DC5C99B4C6AF58" modified="2018-01-31" version="1">MGECAVMSLELRAYAVCVVVVMRAMMMAAVILGQLLSPPSSPMPRASLTIPPVRPCKPPLGSTHLRPRPIVSANSRSPLHHSPPRTHALDVLTFPRGSPAPLRRPSSAPKRSDHKGPCISTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPQ5</accession>
    <name>A0A2G8RPQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPQ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPQ5"/>
    <dbReference type="OrthoDB" id="2737924at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47481:SF7">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="267" mass="29143" checksum="B8B95C889B22E6CD" modified="2018-01-31" version="1">MAPSIPKLDDTNYAEWRMFIKALLTRQGLWGVASGTVTCPQGSPNARTVVAWHKKNDEALAEIILNLHPDQLSHARGSDDAHTVWTNLQTVHQSRGFGTRLSRRRNFFSMVKRDEQSMTSWIAEVHRAAFLLEEIGAVVNDEDVILVLTKLPSTFDNIVVNLDSTPPQDLTVAYVIQRLINEESRQSSSLSVDGTLAGVARARTRTPLAHITCYRCSQKGHYQSDCPLPAPATATAGTPAAAAIAAPIALLSVGGPNEPEEEDAFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQF6</accession>
    <name>A0A2G8RQF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQF6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQF6"/>
    <dbReference type="OrthoDB" id="2757351at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="95"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="286" mass="32698" checksum="6F50B0C35B848ACC" modified="2018-01-31" version="1">MSHTAGNIKDDDQMNSNFSDSNSETDESERGADKVKHDIALDCGICPNVQMRQEGLTRSPRRSWHWIETPIKCKISPTGCPFTFDTHEQDFLHNGDEKGRKALEELARHMSHLFCLPHRTFAYAIYVFCNKEHLVYFNRSGAAVSEWCSFEEDLHLQRFVYRLAMASEVERGHNPAATLVPSSSQDAKDFRTLVDDVRQPELLWEWVAVSTKRKCPIYRLRAISEAAASNTDSKHCGETLAHRDFLVGHPHFYSDSLFGHCTRGYIALDAARKTLCFLKDSWRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQG7</accession>
    <name>A0A2G8RQG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13499</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQG7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQG7"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd21383">
        <property type="entry name" value="GAT_GGA_Tom1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="329"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="486"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="526"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="682"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="715"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="765"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="639"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="841" mass="91349" checksum="EBCEFBE520C9F8FC" modified="2018-01-31" version="1">MPLRRRSTVPYAYNPGNLCYGQDRTGWQATWAPSNHHYSYGAPPAPQPAPYYPPPPGPPPSQPQASPQNTVISPEDDVQRLFNVCKVGRGNAELLQEVLVYAKPQELKNDITKELVGRARASHDLIGSQIPWATSEAEKSRRAAHSPVHTTEEQLLESLLAAHGDLTECLKMHEDLERIAIEQEAEERRKTERLIEALTVVAEYQASTEESPLIEWVFTTGDPDRTGKINPQTATRIFSASNLPPDALARIWEIASVDSKDGLLDRQGAGVALRLIGYAQNGTAVAEGLVKRPGPLAVLENISPVSSEPIAGPSSGVILGALPPMTSHDKAKFRKIFKTSGAQNGILGGQQATEVFMKSKLPRNTLLEIWNLADVQHRGFLDLTDFTIAMYLIQALMTGKLASVPTTLPRHVYEEAGRQSPPPSSTPSHPNLPPPPPVHPTRSNFQPAVPPVAISPFADPPPRHPSSRIAPSSRPPSPPWEVSPATKVQADHVFSTLDPRSKGRVKGERVRQYIQQSGLTPHATGRIWDLVDVGRKGFLTREEFAVAMHLIKTKKDGQHLPHSLPPGILPGSSSSEHSDAYTGIVPDASQHLGPISGLAGTSLHIPAMSEDRSRLSVAAPSSLRSAKSTPHLSTLASQPSTTPSLAPSTPFPMSPLPTGVMTTTYIPSQPTNPEQWNIKPEERARYDRFFDQLDTQRKGYLLSDVAVPFFGRAKLPNDVMATIWDMADSEHDGQLTRDDFAVAMHLIRQKLAGKELPTPALVQAVASPTPSRPSSTATLPRRASLPAPGEASSHRASVSSQQPPQPLHPDPTTVRLPDDVDEDFRSDTPPPPYELIAPDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RR68</accession>
    <name>A0A2G8RR68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RR68"/>
    <dbReference type="STRING" id="1077348.A0A2G8RR68"/>
    <dbReference type="OrthoDB" id="2155101at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="85" mass="10004" checksum="13A133DDC550D5EA" modified="2018-01-31" version="1">MPPPLLSRTLDPVLGVFTGVFAYYLYETHPRTALSEELRLTSLLWWKREKWQRERERKLQATEEVVDWQAITASVEAESDKSPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRB1</accession>
    <name>A0A2G8RRB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_13798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRB1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRB1"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL24047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="113" mass="12704" checksum="64B67FC5D73E8716" modified="2018-01-31" version="1">MNVQNLATFDPFADEGDPLSNTQDVGSQQNYIHIRIQQRNGRKTLTTLQGLPKEYDLKKLLKAFKKEFACNGTLVDDEEAGQVIQLQGDQRLKISTFLVEEGIPKATIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS72</accession>
    <name>A0A2G8RS72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS72"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS72"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="46"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="264" mass="28327" checksum="4F70AB9D5DCD770E" modified="2018-01-31" version="1">MFAATLRNSAKTLDFARCSTTSLRTFSSTSRAHTSVAASFVQQGKKIVAIGRNYSEHAKELNNAVPKEPIIFLKPTTSYVASGGTVEIPQGILAHYEVELGVVVSKRGRDIPASQAESYVAGYALAVDMTARNLQEEIKAKRLPWTVAKGFDTFTPISSYIPKESVSDAANLNLTLKVNGAVKQDGNTKDMIFTIPKLIEHVSTIMTLEEGDLILTGTPSGVGPVVPGDKVECALKDSTGKQLATLDFAAVQREGGYLYKPESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTG3</accession>
    <name>A0A2G8RTG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ESCRT-II complex vps25 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_12688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTG3"/>
    <dbReference type="OrthoDB" id="245150at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13149:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL24802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21550" checksum="F0C031E27E1B371D" modified="2018-01-31" version="1">MSTTLAPYTLPSGFVLPSIHSGPPFFTQQPSPSSRKIATDNWTRLILSYARHQKLFVLRTEDADIPGGEWDDVLSNPRINRKIRAPHLAAVIAHMVATDQAVYDPPNQTSAVLLYWRTPEEWAQVLYDWASSTGHLNTIMTFYEIVEPPVPSPLSDLPLPILRKAIAVLAKSSRAQVIAVADGEGVRFLTAPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RTL4</accession>
    <name>A0A2G8RTL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL24840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RTL4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RTL4"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="129"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL24840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="229" mass="25411" checksum="6B14A14B21D925A9" modified="2018-01-31" version="1">MAPYFETAKSFADVPITGDGVDTATFLLASTDFVNMFDLLGGGVFAFVQNDLRTNIAGVRHRFDAAPAQSSTLEKLVVNECTGGGARHGTACLVRLVRYASLRSRNRLTQTSGPCPPATTHAPARPTKSGLWFTCEALRNMQDDKNAELHICFRRSYDVILKHHHTFVIRTLVALAIRAVPNRQDFYARLEQGGSHEKFDDELRRWLSSLDGLVLRLKAFLSEGHYGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUN1</accession>
    <name>A0A2G8RUN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUN1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUN1"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="21"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL25213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="134" mass="15142" checksum="E5AEFE8ED21018CF" modified="2018-01-31" version="1">MTLRHRPAYEEEDASALRLGSEFNNAGCLLISEVRYLLEHRPSEKAAPDTSVYNKTLDYVKTFAKFDKPEAAAAIRETLRRESALTQFEIAQIANLCPVTAEEAKSIVPSLVKIDDDKLQPLLDEIQTMRKFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RUP4</accession>
    <name>A0A2G8RUP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_13120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RUP4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RUP4"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL25231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="750" mass="85439" checksum="CE31FB0F933CAB63" modified="2018-01-31" version="1">MSAVPTISAAQAVGEYLQSPDDLAKVAAFRKKLEKEKASIDARLRSGVKEQLDATREGLRKLFGTRNNVQSIKDEMETVDKMCGDPAYAVSTFDQISRVSMVHRNFEQTEEMVNNLLEMNSKLEMLEQMLVDDSNDITGPAPNLLSIHFQLNRLEAFRNQTMHQAKKSSTDTRNILNRWFERLTHLIEAFDDYVLEIAKNVLPIVRAGNPDVIVRLMKVVEMEAREDEKAIAIKLVKKAGKMDAASKFRSMQANARVIKHYRSKVMKCITDSIQAKFDEVYAANDRNPAGFLDDLVFIYKDLIRIESDVVPCFPPSYDIWSTFVREYHKALNNTLNRLVKSEPEASVLLTLHAWIKEYKKSMRELEIPPELLEPPLLEGKEQSLIEDYLQLIIKKLDEWSGNLMRTEVAAFTAREEPPEVSADGLYTASGTVIFLDMVNQQVDLALDSNQGLVLARAVEEVNRVMRSIQDRWVKLVDTEYKKHTEKPDEVPGGLVEYCIALANDQIKSADFTEGLSARIESLVSDKYRVTIHDRLNDALDGYLDVAKRCTQTLIGIIFNDLKPAVKQLFGPTWYDGTHAQIIETMRDYMSDYQAFLNESLFEVLLEDLLDMYLVTYLTALVNGPKLNMPAATDRMKKDLDEAYQFFGTYKKMKELEPQMEVLDQVLAMLEASKSLAFLSYWSFAKAHGPCIQFVEALMKLRSDLDRSAVSEVMESIKRKVKEENLADPPEPTIMKKIVIQGALSRFLVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RV24</accession>
    <name>A0A2G8RV24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RV24"/>
    <dbReference type="STRING" id="1077348.A0A2G8RV24"/>
    <dbReference type="OrthoDB" id="2801423at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="2">
        <location>
            <begin position="227"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL25361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="438" mass="50393" checksum="62558E0839ACA22A" modified="2018-01-31" version="1">MNSVPKTPQRPSGSLGTAEPPSSQRKKPLSAAQKLALVMEHLAKVDWSIGDLLYMLFRTRDESGNPISHPKSLETSLSHFLSGRTLHTPIEIIQLWHIHPYSDPATTPERHEPHYSFMKPYLEVKHAKAAITAMVVQLCEKALLRETLRSLARQNALEITRLGVDIDRWFIARFDNVQQQFKLYEQRIGRESTMHIGVAGTVAEAKDFVPSAADLDDRLMRLQQGLRKDLTIEKLLGMIDFDHLEQIASFQWLQTLINYVPALHPYKKDITKTYHDISKLLVPTSKTQIHTLAPVAKNEAVTTDLRDTIVDFLRQLGQSEDSYLRRLALMGGDGLTFEKMVKIKQYLQGQVDEFKRFDIIMPFLETWHTQWTYLCSIFQVHFDESGSQDPSKLGHSMTKMNQKGPSNLKRVEYYKGCFAAYKTLEARQIDCWRYRVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVL6</accession>
    <name>A0A2G8RVL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">GSI_13258</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000056">
        <property type="protein sequence ID" value="PIL25368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RVL6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RVL6"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PIL25368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="138" mass="15486" checksum="B8078EAB743DB2EF" modified="2018-01-31" version="1">MARTKQTARKSTGGKAPRKQLAAKSAARKTAAATTGGVKKPHRFRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDLALARRLRGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWF4</accession>
    <name>A0A2G8RWF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWF4"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL25658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="23367" checksum="EDBEAAFEE0901610" modified="2018-01-31" version="1">MRSVARSVVRILGGRARGRGGDASGRTRMVVTGGVRVALYRLARWDRRDASRATRCVTRRMRRDLRRRARGGGTNVGRGMLRDVASSVRRELGRLARGDGARRRSTVGDVPGPMMRVLWRRPSGSRRDAGRRTTLLVTSGVRVTLGRRHRRSGTSRDASRTTSRSIASGMRRDLGRQAGRGGRNTGRGTCWGLPGVVRRELRRRTNRGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RWI6</accession>
    <name>A0A2G8RWI6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Heat shock 70 kDa protein C</fullName>
            <ecNumber evidence="5">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Transcriptional coregulator SSA1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">GSI_11632</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with transcription factor HSF1 on chromatin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL25879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RWI6"/>
    <dbReference type="STRING" id="1077348.A0A2G8RWI6"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000056">
        <property type="entry name" value="Putative Hsp70 family ATPase KAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013923531" description="Heat shock 70 kDa protein C" evidence="21">
        <location>
            <begin position="22"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PIL25879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="660" mass="72207" checksum="41A12AB3DEB29663" modified="2018-01-31" version="1">MSLVFLAFLALILLCPVSVNADEEKAKYGPVIGIDLGTTYSCVGVQRGGRVEIIANDQGHRITPSWVSFSDEERLVGDSAKNAFHSNPENTVFDAKRLIGRKAEDPEIQRDMKHWPFKVTSKGGKPSVQVKYRGETRDFTPEEISAMVLGKMKETAEAYLGRSVSHAVVTVPAYFNDAQRQATKDAGTIAGLQVLRIINEPTAAAIAYGLDKKGGESQIIVYDLGGGTFDVSLLSIDDGVFEVLATAGDTHLGGEDFDNRVIDFLVKQYKKKTGTDVTPNLRAMGKLKREVEKAKRTLSSQQSTRIEIESFENGNDFSETLTRAKFEELNMDLFRKTMKPVEQVLKDANLKKEDINEIVLVGGSTRIPKVQQLLKEYFGKEPSKGINPDEAVAYGAAVQGGILAGDESLGDVVLVDVNALTLGIETTGGVMTKIIPRNTVIPTRKSQIFSTAADNQQTVLIQVYEGERSLTKDNNLLGKFELTSIPPAPRGVPQIEVTFEVDANGIMKISAADKGTFDSGKSESITIKNEKGRLSPEEIERMVKEAEEFAAEDEAQRKRIEALNHLSSFVYGLKTQLADQEGLGGKLEEDDKKTILEAVKQTTDWVDEHGQSATAEELEEKLSEVQAVVNPITSKLYASSGSSGSADKDDEEYSRSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RX10</accession>
    <name>A0A2G8RX10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RX10"/>
    <dbReference type="OrthoDB" id="2757923at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="20646" checksum="D5BBE5C698ACCBA4" modified="2018-01-31" version="1">MKPRNSHVLVVLSPYLSDPSCVHTDPNMIPQFVPVLAVLSAVCGSHAAATAGGVSYVLPGFPGGEAVTAVLLGTDSAGHATYSLGFALPVTTASTATAPDLTVTAGATLVEGPTDAQVVEIITVGTEAFTYQENCALNNNGNAVCTLVGKNKATTVSTAVTVTQSLTGVSVVTASAPAKNGARHVAAGWAGAAGASVLVAAAVVLGGAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXR1</accession>
    <name>A0A2G8RXR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXR1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXR1"/>
    <dbReference type="OrthoDB" id="2749026at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="234"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="313" mass="35745" checksum="96B6B45A8F8D97F4" modified="2018-01-31" version="1">MWLLSTDRAELHYFARNFDAIGGYAVLSHTWSGDEQTLQAVRAIGERCRASGTNPRDDPALSSKVRRCCILAEKHGYRWVWIDSCCIDKTSSSELSEAINSMFRWYKEAEVCFAYLADVPSDCKLHAPDSAFWKSRWHTRGWTLQELIAPDFLIFLSADWLELGHRAELAALLEQITRVPSEVLTGDIAPAQWSVSIRMSWASSRKTTRVEDEAYCLMGLFGISMPTNYGEGKKAFIRLQYEIMQHNPDMSLFAFGYPVDQDHDLNFQPQEQVNGSWQFLMTDSPRELMSGFEYIPDLGTNTDQQYPPPLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXV4</accession>
    <name>A0A2G8RXV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_12080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXV4"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXV4"/>
    <dbReference type="OrthoDB" id="2796815at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55493" checksum="E0A3F8165E0F9C36" modified="2018-01-31" version="1">MAMAIVEGALRPGKTKPTGLPRDSKRLPQPISQLEPTSFINRMLHNMPDPSDGDGSSSSSSSSSSSETSGSSGSPSPSPESSSSGSDSSDDSDPSSDESSSSSGSSSRRSRRHRHKHRHGSKKRRSSRKHKHGKRRSSATVPVLKPVEPEKYFGNPDLAEFHRFISQAQDYLDGYRVKPRKHGSVIARFLDGRAHEFYVNTVSRNSKEWPFKKILVGLFNYCFPINFRQKMREKLRNIRQNGQSVQTYTYELENLFLVLGMDRNEERVDAFWFGLDKYIQGELWKQMLTLQSPYDDVKARAQMDVAHTLITMTVRDRVTTLPDPVTRPPDRELVRMTDSTVMEGGVADGMLSAPPGVASFNMEIAPDVTEALRNLAESTASTGEVHLNSVEFDYSLLPSLRPAWELIAQDLVPLALGSAAPVSLGEPSADDVDDVWADMPSLQAVSDTLSEYTTAEEGDPPPSQLHGGPSSSSSSDGGGCVVPVEDDSVRVSEVDWDELEFPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RXX0</accession>
    <name>A0A2G8RXX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_12119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RXX0"/>
    <dbReference type="STRING" id="1077348.A0A2G8RXX0"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF100">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="119"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL26363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="503" mass="55982" checksum="B3DEF2599162710B" modified="2018-01-31" version="1">MVKKLKLERINPDLSAEEFFSKYVSKRRPVVLTGLLDDPAFEGRKWTDLSYLSKKAGDVEVMVEPIHPTANQYGTDVERIAMKFREFLAKLRSDDGPHPYLTTQYSDQDPDAETVFPPPTNALKDGFPTVPRIMGNLFLQQVNLWVGKSKDGSSSGLHHDFHDNLYCLLQGRKRFVLFPPSEVKHLYPYGTLDTLHQNGLIAYTDIPVRSDGLSRRAACKARVHALERKIDALKAKSKGKGKDKVHSKEMKALMDAHDEALDELGMLTLEEEVNGEVDDFDVLMAGLEDGDEELGAVPSGYADEDEEEEEEESAEDDEDEETKWPEWRGIGHSDNSQDEDADSSSSNGSQAGEPPSFSRIPTAHLHRYLDIPTTASLPAGFSAASVSALRKATAPYVVELSAGEMLYLPASWWHEVTSTSGPSSSGDSVKGGADIHMAFNYWFYPPNALDNFEAPYEDALIWDYLRAKGKPERTDHKGTAEKVQVGKRSREKGNSEGSKKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYA0</accession>
    <name>A0A2G8RYA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_12243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000045">
        <property type="protein sequence ID" value="PIL26485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYA0"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="342" mass="38551" checksum="E2E7A977FBA481A9" modified="2018-01-31" version="1">MDIVTLLAWRSTSRANYVDACREMHTSLSAILQSFVPNPDVLLGLITDCRALLSGQLALAYLLRDPAVVPYSVDIYVGDLWFDKFMDRFHSTPDLNDYESAYTMLTHHPAFTASRHITHTVELYLSTGRTIFVHASASVSACHALVCSPTSAGFTFITAQCFATAYPMLTMNRRAMVSLERAAMSATSDRLFIQWLEAHRFILPTAPSEWWDYSGATHVESSSDIRRDHCLAVHREICPFRARYFGDQHSFINFIDVLDVDYGLLRSMSVPPYGIMAAWRLPCRDPCQMDCDRLDDLLMHLELISTVIFQTDVDSLGTDCDAMLTNTADPLSCKAQHTNMYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYQ1</accession>
    <name>A0A2G8RYQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_09555</name>
        <name evidence="1" type="ORF">GSI_11260</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000042">
        <property type="protein sequence ID" value="PIL26635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYQ1"/>
    <dbReference type="OrthoDB" id="2755983at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL26635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL28404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="178" mass="19560" checksum="5E50AEE4344A38A1" modified="2018-01-31" version="1">MPGFRAVGDTIGPTYKRLAFAQRGYLRLSANTALSEVSGVSGSKMRWELLEYVLYVYLKLRVQLVGWPGDLVFTNLSNPPLTGLGCISRLVALWDSGAMHFAPVTDAEYRAALEDPYSCAPGPLHRGFPENLGRCDIKKRKYRPKTDPLGLRVGRYIRNGPKSARVVSETAADGAEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RYZ5</accession>
    <name>A0A2G8RYZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_11231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000040">
        <property type="protein sequence ID" value="PIL26704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RYZ5"/>
    <dbReference type="OrthoDB" id="2757163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL26704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="201" mass="21580" checksum="023D182065F4C360" modified="2018-01-31" version="1">MYSGVSSGVAASVLSFSTNLCATVLVGYKAWEARRRLRQYIVAGPVASQMEKVFALLVESGAAYCALWAVVVAWQIGDYQTEVETNAGNNTFWDIFGVIINDALVPLIAIYPTIIIVLVALNRSHVENGMASTGQTSSTGASIRLTTVRVDTTVASHHDHQLPRRSEVLVIGEREFGLGSISEAGASTHAVNDERKIDGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ55</accession>
    <name>A0A2G8RZ55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_11142</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ55"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ55"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="980"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1033"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="908"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL26806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1099" mass="116671" checksum="A5CFDA9A7BF4A34F" modified="2018-01-31" version="1">MISAFPSPILSVAADVVKDLEGEDALCSLWALFTKCKESLKDGRRLENISWRLWYRELAAAQCTPSSSPGSLSPPFSEKRSPSPITPVSEDGHLSQEVLVPLPCPSLTPASDVSTAHSWHAQNSANTVITAGRRLSTASAPMERRKSHSAVGVGKMILDILPGKLDVSSEKEKAARAPSASVATSTPAPATATVPQIAQPRPVVAALPTMQLPATPPQPERASLSFPRVVVVNPTPHPTPPATPSIAHPPHHQTPGVARPSTSSSSASASHLLSPPPLARSLISATAPKHQHQHLHLKPPSPPRLAVSSKHAGSTAKSGELARELQQEGASCSLTSKQQPSSSSSCAGQGQGQGSGSGSHSHSHDGIPSLPTADARPRPRQDTLKASASASASDRRFFLPSSGGSPSSPERPQSATTTSDAVLSPVSPAPSAEHEHERDGDESEADADVKEASERDQQLQEQAPEREHELEHGLSPSSATSSQLRSPTTAAGAGAAHGHGHGHGHGVGGGGGGGGGGKKRQVQARKNKERHAPARPAALQRLHSHGLRTTSAKKGAGQQGAGQQGGERQGQQEKEKERQEKEKEKERQVPHTADARRTTFNIGSVSSNGSGGGKSSKAVEVEVEVEVEKAKATKETKETKEKEKGKGREKEKEKEKGSRERRREGSSSRTRHSLSPAPNPPKKSASTPHIPATAAAPAMTTTATTTTTAKTKANGAGPSQPRRGIVISTSSEYETTDTDDDDSDWASEDSSEDRAKDKAKDKDKDKGRKAKAQAAEDARLLEAAEEAQRQRDMFAKVPIRSYSNLGRVQSGLLSQLLNPDPNMFPPNHPYRSIRSTQDMTQLARAPASALQMQMRKSTAAVPLAAQVQVTAQAPSPAPAPPAASGKGQGQGQGQQGSGYKKAGRPEEMEFSSDDDENPDDTIQVSRSVAQQKLAALADPNRRRHSDRALPPSQLQLQLQLQRQRQAGMGEGRPQLQSVATAPIPLSHPYNLPAPAPPMTPRATRRQMLQTELSESLRRNLLWERQVSRVNLTGRRAGGLGGGLRPMTAVNGDPAAQQQQQTQGSGQGSGQEGPDDKEEKRRRAMARNRSWADEYHYSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZ91</accession>
    <name>A0A2G8RZ91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_11143</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000037">
        <property type="protein sequence ID" value="PIL26807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZ91"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZ91"/>
    <dbReference type="OrthoDB" id="3269380at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL26807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="41913" checksum="59EC967B5CD35293" modified="2018-01-31" version="1">MFSHELFDFASTGHLSDAHIDAPDPYHDALFDSYIDSSCVDQSFCSDFACCGQALPDLHRLLEHFEEDHVLPLPSDARPLFSSPVYAQPRSGSCTSYILSYPQPDPPLHTPAAPHSIPASPTPRGVLPSLQFSEIPPVAIPDLTHTPLSPSPTTSSATSAHSSPEPGEPLCLPPALFSFQPNATSSRSRGLRDRPRGHATSDTDEDVDMYDSDEEGSTGADGGFEDTPPRTRSAPTPTSSVSGNTAGPHRRVKNKTSAARMEPFAAARRSPSERAPSSPKRRDGREKAFKCPCFPASDAAADADDTVCVPARQSYLNPNGLKYHLEKGTCTNADARARDPLPPSSPSSVVASRSASVVPAAATMATTLETGPDSMPPSGGVADADDAASSAGPAEVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RZZ1</accession>
    <name>A0A2G8RZZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">GSI_10204</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000034">
        <property type="protein sequence ID" value="PIL27065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RZZ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8RZZ1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000032">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon 297-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="18">
        <location>
            <begin position="254"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="17">
        <location>
            <begin position="554"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="601"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PIL27065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="620" mass="71627" checksum="48D6F82801AB8E04" modified="2018-01-31" version="1">MSDAERNYEIYDKKMLAIIRALQAWRHYLEGLPSVFEIQSDHKNLEYWKTAQNLTRRQARWALYLSRFEFVILHKPGTSNGRADALSRRPDHQTDDADDNLDRVLLQPDRFRVLAAKRGHMSVVPEKALLRRIRECGEREQEVADALSKLDKLGPARLQNDLVDWNTEQGLLLYRGRVYVPKDDALRAEIVRIHHDLPPAGHPGQAKTVELVTRNYWWPGMVKFIKDYIETCDTCRRGKTSHAKPHGPLQPNEVPDGPGQVVTCDFITGLPDVDGYNALQLIADRHGKIIHLIPCTEEIDAEGTADNFIREWFRLHGLPRKIISDRGPQFSSKLFRAVLKGLGIESAMSTAYHPQTDGQSERWNQEIEAYLRMYCSRHRDDWVKWLPIAEFAFNSHVHSATGYSPFYLMYGFEPQFHIPMLSTAVPSADERREELRQAREDATSALTLAAERMKEYYDRYVRDAPEFKDGQKVWLDTRNFRVKGVSRKLVDRYAGPYLVKRKVGNLAYELKLPKDLALHPVFHVSLLLPHKESQLPGRHPPEPASIEVEGEEEYEVEEVLESRRYGRWKKLQYLVHWMGWGPEHDSWEDAADLANAPKVVQKFHSTHPDAPSPLNKKTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S2C8</accession>
    <name>A0A2G8S2C8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000032">
        <property type="protein sequence ID" value="PIL27930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S2C8"/>
    <dbReference type="OrthoDB" id="2748713at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL27930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56542" checksum="F0F018CE00BCFB8C" modified="2018-01-31" version="1">MSRLNLDVLCSVCSFITDVPDILAFSLTCSTLRPPAIRRRLGMRPVVITDAMSINTLHAFIFVDKAGRSPHIRAITIPQEAGPLLKGCPEDLLHRLLAILSAATCVRTLSLHLPSRSSSSLLAHPLIVPAVARLTGVEDLALVSSFERANALLRCIRSPLKVFRYGSLYDDLSALRNTSLIGSSMRLSSIRRRIAMRQEMDEEFTIEVANHLSDTLSDLELPQVCLPRQPFLRLHPGPFLAVRSFVLRCVTEPLRLDVLLHILPNLDSSLVVEALPLFYNSMRDWQRVETIQEANRFAQERHAWKKLDRVVASPLMLFALGLTCPIRRLTLDLSADENSPSESADAFARHALGSVLRDHAPAHLTIRGLRLPAGLEHLDDLFSTNNALAGMTHLVVNAEYNSVDDGGKLLWPEEALDTLLARIQYSSLTHVHIEITAIIREADPFSGSVYHGIRDLPLERLATQFQLAVPSLYHISVTSRGAVLQSDKELQEVWNLPPRLSLENISRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S311</accession>
    <name>A0A2G8S311_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_09785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S311"/>
    <dbReference type="STRING" id="1077348.A0A2G8S311"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL28134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="178" mass="19090" checksum="A0C58097D667B6A3" modified="2018-01-31" version="1">MLAYRALGLGPALRQAALNPRNVARNPALRNLVARRFVQTESLPPSAAQAILNKQRLLRPSSPHFTIYQPQLTWLGSIANRVTGAGFSVLLYGYALAYLVAPETFSSANVVELIASLPEAVKYAGKVILAAPFAFHSLNGLRHLGWDMGRFLTLKGAYSSGYAVLGATAVSTIALVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3H7</accession>
    <name>A0A2G8S3H7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000028">
        <property type="protein sequence ID" value="PIL28108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3H7"/>
    <dbReference type="OrthoDB" id="2425321at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148">
        <property type="entry name" value="KERATINOCYTE PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48148:SF2">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="853"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="770"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="92561" checksum="7FF312A7362BD74F" modified="2018-01-31" version="1">MSTATARTLPTPPPVPSYQPTSPSKKDPALKPNPHPYAIKTTSTALLTRSNSSGYNVNATHHYYIPPSPSHSRSDSGKAHRATKSLTAVPESPGREAPRPLPIPPELDNTQPRKDGNAGSAGYVSADEPSKARRRPRRSETLPIIPIPSPALSAPPSLDDLPENPKMWTPSQLAIYLTTALRMTSGGKPGDIEPIGLPALVAKDIATFVKSARIGGRTFLRLNEEDLESLGMNKKWRDALLVAARNLRQNVLKGRLWGGDLSPIPSPSPAFASAPATVSVLRPDPSPSSSPTRLYSNPTFNSSSSSVESSASFSTGDEDGPGGAGAALGRAKARRYRNGRVRGMVETFERSGSFSSDGGFDDDANAAPLPSAPTFSRKQLRDLAQAQMQAQLTGQGQHVESRSPSPSKRRPLPVPPSPSGSMSASASGSGSAPMTLLDEEPTMEALLAELGGAHPPPVTGARAWEEVDLANGVTVKRVPAHAHAHGTTATMTTTTTAVGQKTIQGLGSGRSSGGSSSGKGGERRVVTAIFAPHAQGEPPEAPVPLKPLEVASIADLTALAEKEGTGTGTGTSMPTPPPDEHPSVFVSVSVSPSKSESGSRPLPSPPASASEDARAEQDREAEAQRAAAEAEAKEAALLAFERMLEEEVLATRALVDTFRARLEIVEQKVAELEAHEREALRAAAELARRQQAQAQALQHEDVRPQPHPRDQDQEQEPAAGASAGGARVESVEIGVQAEFAQPESSAASAFAGAVPLLVAVAEAAVQSVNEGDAGGPQTQAQLQLHPSSASASARGPASARLRAAEPQPQAHRQIMPGADSDADADTGDAAQKREEEEEEEEPGDELPSHLSELPSYVLLAGLGVCAVVTQVVVRRVFGRGMWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S3K5</accession>
    <name>A0A2G8S3K5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_09511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000024">
        <property type="protein sequence ID" value="PIL28360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S3K5"/>
    <dbReference type="OrthoDB" id="2750874at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL28360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="61495" checksum="57D808CA4467C2C8" modified="2018-01-31" version="1">MSHHFCHSLSDSLSRLDDDSLLELFEHVNTYGGLHSLSLTCKWAREVCKPILFRRCRWAPGYAFNSPHSIPETIWPYVRSISIHGNFHLLKYESNYYPYTPVGYDVVYAPLTTSLCRLPRLHTLTIGSTVGGVPWEAINAAVQVPQLRNLRISGFLDHRDILPAKTEQSLRLPVHSLATIDYPSSGYRKVSATEIKIFSVLLHQVTFQRSLEALSVPSECMSLDYLSTTQFPRLRELALIGRRQHSDGQQDVPYISILANMPRLRKLALTFSQPIGLPRQQIWPVDMAAEFPCPDLEDLSVSYPHPDDEFYAHLPPTLRRLTLRCWPRHYLHLLEHDRRHMTAKYGWYSPILSSSEMLRILRRCPSRNIRRLEVEFEEDHSGRDLFFYISEAFPQLEYVVIHRYRPVGGVEVTSVATLAQALAPLRRLRILLCNLDFEDAPDPFGDDFAPFINRLQDVASILASSLSPSVEIIGLLLRHGMLTPYEYFRPIRDGRNGPRARHDKYVYKTHGMPYVIVIVHRREIVPHDPVIQFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S605</accession>
    <name>A0A2G8S605_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_09015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000023">
        <property type="protein sequence ID" value="PIL28968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S605"/>
    <dbReference type="OrthoDB" id="3168922at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL28968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="237" mass="25480" checksum="79C57EC4431DA74F" modified="2018-01-31" version="1">MSQPLQGSAVSAVRASTSALRTSTRATHWRASSRRMSSVAAYPIEEPNSPSFDLNILDIFDAPSRLGESSRLLVSNAAASSTIRRARLPTQVSPHRHVVKPLPEPVVLDGPARPRHAPFVSFRAFNNAVPRRNVNVSSGAWSPPAPLPTPILFDGPSQLRPYTRGGARWNRYSPSSLAMSAAPIVLALAAGVALFAVDVTSAAPRKSPRPDSDADSTSLSPTSRRGRRARDRLSFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S722</accession>
    <name>A0A2G8S722_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_08209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000020">
        <property type="protein sequence ID" value="PIL29573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S722"/>
    <dbReference type="STRING" id="1077348.A0A2G8S722"/>
    <dbReference type="OrthoDB" id="164902at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="260"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="156"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL29573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="344" mass="37968" checksum="84174C4FD34BF072" modified="2018-01-31" version="1">MDSDEYFDDDLDSSFLNEVNAIEAAHVAASAAATPRESPPSRSKPLLKPAAMSKSQYKPTNAVKLFPQPRPLSPPRAAITEGDDSSDHYFDDDPITLNEADCATLDAVAEGRKASRTGSVHVHSISGSSGPSNLPDRHSHLLQRNLYGEVVRDVEPSKTISTTRPFQRTRSTLRQMPLPGLAKRSKQWDRTAYAKTGWRKPRPNPEKEKEKEKGRTSDNDGEEEAVEFEQFPAPEVPVGLAAKTWIYPLNKPKRDYQYNIVKKCLLENTLVALPTGLGKTFIAGVVMLNFYNWFPEGRVVFVAPTKPLVAQQIDACHKTCGIPGSTAAELTGNVAKDKRITAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S889</accession>
    <name>A0A2G8S889_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07876</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL29965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S889"/>
    <dbReference type="STRING" id="1077348.A0A2G8S889"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="6">
        <location>
            <begin position="50"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL29965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="449" mass="49246" checksum="F00FED54B6F792C0" modified="2018-01-31" version="1">MPAGALLTNDAQAVIEAYAGCYLTDGENVIVNLARFVMNRIGVAGLALEVAADVVVSAALVYYLVTSRSGIRRSDDMLSRLIVLTVTTGMLSTCVAIANLYIAAPGALYVLFFDFLIAKLDANALMTSLNSRDFVRDGSHASTSRLGGVSDVRSVPLSVLRVPPARVQAGSSTTMEQDLLPYGIVDLKVDADRAQVCYFKPSDGGGSRMNWLYAARIPAVAMLMVAERVAFIAPNNPGPKGEEIAKYGRADTVTRIATWFPIFSLAVDYTCHLCEMTAILAREFPSLLSDKVLLALFSDPSAVDRLNLSPLFLFGFVLLLAGATMRQVCYDTLGKFFTFQLAVFKGHKLVTSGPYSIVRHPSYTAFLIARAGLFVVQIFPGSYVYESGLLDTRWMAIVIGIWEAWILSIVFEIVVMRIPREDAVLRKEFGAEWEAWAKKTPYRLCPYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8C1</accession>
    <name>A0A2G8S8C1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_07983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="AYKW01000018">
        <property type="protein sequence ID" value="PIL29778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8C1"/>
    <dbReference type="STRING" id="1077348.A0A2G8S8C1"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase catalytic" evidence="8">
        <location>
            <begin position="42"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="9">
        <location>
            <begin position="183"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL29778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="237" mass="26716" checksum="3F70D95C7D9AD25F" modified="2018-01-31" version="1">MPPVASSAYSVTPWEISFLDPLRQSRNALIILNQPFSYSLLRRVWYSSSWHACADGGANRLHDLLKDCDGKDLRHLFTPDLIKGDLDSLRVDVQLYYSSRGVRIVQDGDQDSTDLMKCIGALVDDEKAERHVEQHTIVILGGLSGRLDQTVHTLSLLHKLRHRRKRVFVITDDNVAWVLDAGEHRISVDHENFGPTCGLLPLGIDLTVLTTTGLKWNLSQFFAVFDLLSCPHKCDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8D8</accession>
    <name>A0A2G8S8D8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000017">
        <property type="protein sequence ID" value="PIL30015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8D8"/>
    <dbReference type="OrthoDB" id="2758552at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38550" checksum="D9ACFE65EBBB4B32" modified="2018-01-31" version="1">MAQVDASTILDLLRNTPALEVLEIKSRDVLAPPNSATISSRPVSLPRLQSAHISHSTSAVAHCLMAALDVPSLAFLDLTVHVNGGTLLSVPPLPRALATHPMRRLAFDVGSDSDFNPSFHAALHGSGASLAIGLHAHNVLHTGTEWAQWMLTDLPTTLPLSGIEEFHIRAREWDAPEDALPHLAVYMPAVSTLLIKHETHDDDYDYDDGDDTDGHMELARVVARVLTSDGPVLFPRLAHVELIVGSIPLAFCELLARALGHRDVGGRRLQRLRIRVDDEHYDSFRWRVMGGRVSEYRKTGIFDHVDVCEIPDGSSDGAGHEPNDGDTQRLGWGKWRDCVQQARHEYWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S8S9</accession>
    <name>A0A2G8S8S9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000016">
        <property type="protein sequence ID" value="PIL30144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S8S9"/>
    <dbReference type="OrthoDB" id="2755760at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="538" mass="58514" checksum="B98A0661D00E8A6B" modified="2018-01-31" version="1">MATCSFLYHEGAKVILQDPVELSDSEEKVLALLRFVQAEGFLRCSYVRQLHIIHMPESVAQIMSDIIPRMTNLKQLSIVLAEQIFTSHPYLLPKFAALRSLMTLVIGFVGERCAEMLRTLQSELSFANIHFPVPGMGRLPPTTTSHPLLMLKGSASTLQELTCHNVAGTTPELVPFPPEVVYPELRTLNLHQSKTLPPNPIPFIHAFPNLTTLNVEYPPGTQLVGDIELYRLEREARLAAQRLSQSSAGWRHIQTFTGHPVALWMLGLKCRIPHLLLDYALTVTAAQNHDAPFILADVLAYARPTRLTLMFEQHPLSAVLAGGFVAALKSEGASGLRSLAFVVNLMPADRNLDVGHALTDMEAALSGLRLDDLLFSVRDIGLSENLSTSTGASVRVPLGPPGLAVPPAHPAHMHPAPQAPPPPAATSHSEDTGATRLNPNLNLGERTLNAFDVHALAQRLAAAIPTLQNMLVLVERPGRGQCGGNMRAGWSAKSTWRNAQPMYTGGEVRYTEAGGSGVMREVFASTIRGWNVHIAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S942</accession>
    <name>A0A2G8S942_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_07450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000015">
        <property type="protein sequence ID" value="PIL30272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S942"/>
    <dbReference type="STRING" id="1077348.A0A2G8S942"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL30272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17530" checksum="BEC07BD26CB3B2B5" modified="2018-01-31" version="1">MSDRLNAFPGWRPRPVSMGRIAVKDITLSDGTRIPEGTLLTAQAYAMHHDGALCDNARTFDPFRFARMRPIAGSGSDGQSANAKCLFTTTSAEYIPFGYGQYSCPGRYFASNELKAILACIILNCDMKLGGDGSRPSDVYTATSIMPAPHGRILFKKRGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8S9S7</accession>
    <name>A0A2G8S9S7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8S9S7"/>
    <dbReference type="OrthoDB" id="2762959at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="251" mass="27280" checksum="47B8347960734234" modified="2018-01-31" version="1">MSYKKSNVTGRTWSTPFNTPFFFRWGEWSIKVPMECLREEYDAWEELQRRRRPQGTPTDQEAGETNARPSLTPNAFDWAEDVEQELFSDGSASDSDDSSSNLESAPDSDTDRGDCPIVDPTAPVETAVAGASIDEGEEEVAVPPGGDEATTTPELTTPTPTTNIDNTVYRVIDVSTANNTLSIRMVEDGRPIATGGSTTAQKASEVIQFLAGAGLLKLDTYETVFEIAARGCASGEPFWLHDPALGYEIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SA17</accession>
    <name>A0A2G8SA17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_07316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SA17"/>
    <dbReference type="STRING" id="1077348.A0A2G8SA17"/>
    <dbReference type="OrthoDB" id="2757990at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="328" mass="36150" checksum="40A3FCFFC95EFF43" modified="2018-01-31" version="1">MPPTNDLPPDIRAFIPPLRCKSCQKAEWPTHKAICVDTTEFIRSLPASTNPTQPPLDISTFGYHSIPALCTALQNFGEAHEWSFSALTKVFVAAKGGIAWSQDPQKMFTVELVPVTTLPGIRERNPSRTFRVKSFYSTAVHDHVAANPLGAMDEWVKQEPLRQAAFETYGEDPYYAGLLPLNLGINGVNVTFMQYIPQFWPVPPSRPMPQLASDEAKKILMQDVAALAYCAINEGIPLRATGPEPPGVGFAYPGRTAKTRLNPQLPVVLENLVRLMRTPSVIAVLRCEENPPKPQLDSRLEDHKGEGRKDVEMDGSLRWPGAAADAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAA5</accession>
    <name>A0A2G8SAA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DOPA 4,5-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_07396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000014">
        <property type="protein sequence ID" value="PIL30692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAA5"/>
    <dbReference type="OrthoDB" id="9970095at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL30692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="19455" checksum="E85491BB1FBA8470" modified="2018-01-31" version="1">MAPCTDLKEVVESEIKEWHFHIYFHQRNANEHHAALELRDAVLRLRRDGAFVAVPLFRVNTDPIGPHPVGSYEIWCPSESFVSVYSYLALNRGDLRDHEVRHAWLGPAFPLDLSTLPIKSDNVPLQYPSLRLGCSSTAPKLSLEERKRIGANVEQILRNEKEAAKAPSDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAJ0</accession>
    <name>A0A2G8SAJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAJ0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAJ0"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL30769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="542" mass="59340" checksum="6F85E5156E4B8E8D" modified="2018-01-31" version="1">MGSLVSKAKLFLYATIQLGKTYDVLRKRIETSPGVPVDNPTLPLWTVPRAQIPSHETGPFPQHVDVVIIGSGITGTSFAYNALAREPGLKIAMLEARDICSGATGRNGGHINPPLYHDYAELKEKYGEHAAKLLVTFRMSHVTEMQRISSQESIQKQSQVRQTEHLDVYTCSIAFAEAKQNLEKWRADMPRESSTFVVHERREAIEKYHLSDDVVGCISNAGGAMHPYRFVTSLLAILLNRHAGNFHIFAHTPCTAVTVPASTSTSASSPALYAVHTPRGTLLAPHVVHATNGWAAHLLPPLLTKLAPARGGMSAQRPGSGPGLRAATQAGGRSFVFYRPGGGYDYLTQLPREDEDELMFGGGWATACDDAQHGLPEIGIADDSAVNHVGQSYLAGALPRYFGMRNWGRDAVPRDDDYEGGEGGEGLWGMGRTKAQWSGILGISADMLPWVGRLPEKVSGRAQPRPELVREKKSVHTAAPGEWIAAGYSGEGMVHAWMSGKALASMVLDRDEEVREWFPDILRVTEKRWKEANIEELFARFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAR2</accession>
    <name>A0A2G8SAR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAR2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAR2"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="224"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="314" mass="35794" checksum="A9C15527FB1660F6" modified="2018-01-31" version="1">MDVGTQHMAKLEPFLLMSKAAKGAAAAKLVQDATAAPGVFVFAELLEQPNVQELAGHEQHDRFYSLLQLFSYKTYSDYLQYKDALPSLNEAQITKLKQLTIVTLAQDSRILPYEQLLSVLEMPTIRELEDLIIDAIYLDIVRGKLDQREQQFEVEYTMGRDLEPGKVEQLLVSLQNWASTTSAILATLDEKLSQISGRTASSKKARDIYEKQYQVTLKEVVDKQKEQRNANKQPVYSGKTGLTPAGIAERDRQQERERRAREEAEREREREKQKEAEEDKDRMDVDEPADTKGKGRKTSGSDSSQGQQRKRNRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SAX2</accession>
    <name>A0A2G8SAX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_07083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000013">
        <property type="protein sequence ID" value="PIL30914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SAX2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SAX2"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL30914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33871" checksum="3FCE95A1062A8C1D" modified="2018-01-31" version="1">MSAQAIIEKEFGDQNPLDESLYRLDEEGLTFMKTQACFEDEEELKKHVLAVQAEAYKIHPYPCIRSFGFLLCKIARLPAYEQLLALGKERKDPIFLDIGCCFGNDIRRAIQDGFPQGGAIGSDLYSEFWDMGHKLFRSTPKTFPVPFVPGDAFDPAFLEPTTPAPPSDPRPGLSTLTSLNPLRGHVSAIHASSFFHLFDEEKQLELAKALAGLLSPEPGSIILGAHGGGPEKGLRVETFGPNSHEIKMFCHSPESWKEMWDGQVFEKGTVKVEADLIEVKRTDLVDVPEETKFYIQLWSVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SCE3</accession>
    <name>A0A2G8SCE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">GSI_06146</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SCE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SCE3"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013553551" description="Endonuclease/exonuclease/phosphatase domain-containing protein" evidence="15">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="16">
        <location>
            <begin position="5"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PIL31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="377" mass="41215" checksum="ED108AD446B5D025" modified="2018-01-31" version="1">MNSGALGAGLVILTRFPILAATIHPYSLNGSPIDVVAGDWFVGKAAASIVFAHPILGQVEVYNTHFFAKGGDEGPEHQRAHRLVNAWEFAKLVRQSAEVGRYIIASGDFNRSPSTLPMDIIRDHAGLTDAWAVTHLDTPEPNLHNPPSPQDAIHLYGVTADSPLNSYSAGKPLEHRARKFQGKRLDYVLYRQPSSIHATARIPILRAVDTRVVMTELVPGYHFSYSDHFGVEATFDIEAPGGGHATEPTSVDIPTSNHPKPALSQTDISTDSITEALVSLTARYRFAESQARKHLMTFVLCVLALIAIISTSPWFPSYVNPALTLATVAVAWCATTMLYVGFVYGNWEVNPLTNIIEELELYRAALEAGQLGRLRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDQ6</accession>
    <name>A0A2G8SDQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">GSI_06411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDQ6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDQ6"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="535"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PIL31708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="619" mass="64962" checksum="BBB968E8852FA7D0" modified="2018-01-31" version="1">MVSPLWKAASDGNLESLSQLLREASPVDVEVKDFTGVTPLIEAVKNGHVEVVRILLDKGADPTNGSSQGPPDSYTSDPVILELLSAARSKLGHSPGMHSEVAYSQEQQPDATNVDPASAGFYPPPGAYYYPPMPVPPPMMPDGSVPYYVPPPPMPTDQNSNGLGNLPPPEVARMIPCRYYPACRYGASCMFAHPQGSYMQGPMPPPTQYPASYDSMNPGQYPPPTYYPVPPSPYSASPNGAPNHMSPPPIAHTASGSDVMSPVQAPFSPANGQPPVPYGVVSPVSPTYGHPAPVPISGPVPPLPPLQTSPTVAQPPPPPGMYPSMSPNGQVVPPPYAIPPQYATASVPNGDATDAISPKSPVHPPADGYVPGPISREMSHHRRGGPRRPSFGGRGGKPPCLFFPSGRCRNGDDCRFPHVLPDGPGNHHPSHFSARGGHRPRPPFHANGVAALEEKFAVMTTTQDVDKAPIHVRKGTGASTDSSRSQSAEPGQKGRLPFKPNGNFVNNARPDRKFGAPKPQRVPNADEFPVLGGSVPSSRASSNGTTTPRYSGPTAAQVLQAPAPRKDGQTRGSTPDLAPVSKPEVNGVLPDQAIPKLPLSFAAAATAVPDPMKEVSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDS7</accession>
    <name>A0A2G8SDS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_06616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDS7"/>
    <dbReference type="OrthoDB" id="2736021at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL31912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="166" mass="18449" checksum="6D4BD425AE7DE931" modified="2018-01-31" version="1">MCIPRDVHPHLFLPKTPLLFKIIGQITVEECFLTARGHLRPPDKEPIASCWLQQRPNITSDITWRGIIPTLEAIIEQYGGEVDPSELLALGPDGKLRLQMTWQGDVGETGRDLPIFDELGIQRVPASISDVPFGEAVHAVFSIEFVHDRTAGARTVFASLFAMHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDS8</accession>
    <name>A0A2G8SDS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">GSI_06629</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDS8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDS8"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="556"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="807"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PIL31925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="828" mass="90874" checksum="6305B9CCE8EA5D3D" modified="2018-01-31" version="1">MSRQQTLGKFFGNGGDPPVQAKLEDAFRGKRKRSAKAEKDGKTEELNAIAVKAEQAPRSPSPHKDAKSKAPASKKRRVIESDDEEAPESGPSNINNRKNVSSKPPSSDGPRGSKSASSLTSKSKRKVKAKVALAADDAMDEDEAAVSSAAEENVDEGEEEPEADEELEEDGVASQNAEAALLKAKEVDLPNGWENGNPVPYAALAKVFSLIEATTKRIEKTSLLTSFLLLVIQRRAKGDTKSLLQAVYLCINRLCPDYMGIELGIGESLLVKAISESTGRSLAVVKADLKKEGDLGLVAMNSKNSQKTLFKPKPLTLPNVFKDLKEIAMSSGHSSQNKKVSIITKLLAACQGQEAKYIVRSLEGKLRIGNAERTVLVALAHATVLAEQESANKKLSNERLAARLEEAAGIIKHVYSNLPNYDLVIPAVLNAGIDGLQGECKLTPGVPLKPMLAKPTKAIGEVLDKFEGKKFTCEYKYDGERAQVHKLADGTIAVFSRNSEDMSKKYPDLMEQLPRCVKEGTDTFVFDAEAVAIDKDTAKLLPFQELSRRKRKDVKVEDIKVRVCLFAFDLLYLNGEPLLQKDFAERRRMLKENFQPVDLEFQFAKASDAETVDEIQTFLEDSVKDGCEGLMVKMLEGDLSRYEPSRRTVNWLKLKKDYLAGVGDSLDLVVVGGYYGKGKRTNVYGAFLLACYDSDSEEYQTICKIGTGFSDEALQSHYEALKPLETQTPRGDVKVGGAKPDVWFEPKIVWEVLTADLSLSPIYTAAQGLVEERGISLRFPRFIKIRDDKDADDATGPEQIAEMYQRQALAQSKGGKKSKGGDGDDGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDY6</accession>
    <name>A0A2G8SDY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_06688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDY6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDY6"/>
    <dbReference type="OrthoDB" id="10265310at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL31984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="631" mass="69844" checksum="B047851438833257" modified="2018-01-31" version="1">MSTTEEHPAKRLKVEAKTIGTHNGTFHCDEALAVFLLKQTNTYAEAVLKRSRDPAVLDTCDIVVDVGGVYDEKAQRFDHHQRGFAEIFGHGFSTKLSSAGLVYKHFGKEIIANRLLVSQEDPKIDTLWLKLYKEYIEAIDAIDNGVNQYPTDLQPKYHVRTDVSARVGHLNPSWNQVADSATVDTKFLQASTLVGTEFLDRLDYYANAWLPARDLVVAALEKRKQVDQNGRIIIFEQFAPWKEHLFELEAVLQIPEAEKPLYVLYPDEFGGNWRIQAVPVTAGSFESRKALPEKWRGVRDDDLSKLSGVEGCIFVHASGFIGGWDVKVVIPSSQKSWIGKAYHIKEIVNGRYYYPRDPDGEGEISEASRPLEEGEIGEWILLDGTPATCANIGLHNLYHGDIDLLLSGPNLGRNSSSAFALSSGTIGAALSSSLSKVRSIALSYGTVLHPVPVTFHDPAHSLAARITGHLWNNWGEDEGGLRGGEIDLYNVNIPMVDGLLSDPGLPICWTHIWRNSYGRLFKAYKERDPEAKKTISAAGPDSPSEDPQGTRAGVLDQQATAKDVGGLVFKFAPDMTDLIKPPSVPIGTDGWAVEKGWVSVTPLRATFSEPVEWVVTTEEEMVNTQVWKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SDY7</accession>
    <name>A0A2G8SDY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed DNA polymerase family B exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_06667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000012">
        <property type="protein sequence ID" value="PIL31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SDY7"/>
    <dbReference type="STRING" id="1077348.A0A2G8SDY7"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05778">
        <property type="entry name" value="DNA_polB_zeta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030559">
        <property type="entry name" value="PolZ_Rev3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45812:SF1">
        <property type="entry name" value="DNA POLYMERASE ZETA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="1">
        <location>
            <begin position="178"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="407" mass="45723" checksum="7927070E2C8F102D" modified="2018-01-31" version="1">MATRPSSQLMTVLSPALRSLHCGKNAYVYALRPPTSAELLGSTDEHGIPNKIYRSPWYSRESDAPERPREYAGLVFHLKGGEGIGNLGDWKCGEGASPAGGEPVHPLDPTGVGGWEYASTPPTVRQVRQWLKEQKGRLDSRTVRIKDSSQIEGPTQRNPYGLQSTLTLRSDMAQRMAQNMTVLTLEVFAPSKDDRVPNPDDDEVAAVFYCFQRHDREVGEALTCESGIVAVDSAQFNPRRLRSLQAEFVESELELLNRLIDVILELDPDVLSGWEVQAASWGYLSARGRSYGLDVGEQISRAPGRTAGGYDGWAMKTSSTFKVIGRHVLNLWRIMRSEQTFAIYSFEHVVFQLLHRRRTPWYSPRTLTEWYNSSVPEHTDRVVRYFASRTSMVLEMLDVAEVVTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SEW1</accession>
    <name>A0A2G8SEW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000011">
        <property type="protein sequence ID" value="PIL32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SEW1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="85" mass="9322" checksum="22991CB30B0A92EF" modified="2018-01-31" version="1">MATFPEVSCWLLDGDEPESIDTLSLPHHPLPLWAVDSHDSANEGMAAPYISTNNAARSQSREGQIRTPPLPEVRTPSSVMTYSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SF65</accession>
    <name>A0A2G8SF65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SF65"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="193" mass="20889" checksum="CBB8FD839E85DA6A" modified="2018-01-31" version="1">MRANVASGRLECLAAETLNDVDTRNHTKKLLQFLYAFTRATAQCGFNPTATGLSDISCGRICTLTIAASHRTSFRRYPKASPSPALHDRGHTSLAILCGDRGRGGGGRTSESGPPLPRSLAEGHGPPDRERRLGLGLDPVPSSSQNWPEKPPQKVYDMAAKLTTHDAILRMLARALRTRVWLGDDYAGDQLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFB1</accession>
    <name>A0A2G8SFB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein LCHN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_05145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFB1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFB1"/>
    <dbReference type="OrthoDB" id="2152680at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL32443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="72259" checksum="7911EFC501C1E409" modified="2018-01-31" version="1">MQLESGDPVPQDLVAIFHASFHRTQGNIIDWSLKADEDLDLSHVEFSSLPSGLHLIERDVVYFTKDDYQGVCVFRRRRTSEDGHRGFRLSSLGVLLAKSPRPRPWQHVASLKRLVSSIYAALDDRDTLEPTDSDWDLARDFFEQRKVRQPQDDNGPSSSTSRNWEGWAAELQGSRSDCAPTIHLPHLLRILGPSSLTLYKHVLGRRRVLVITLPPVEAACILCQVAADTCYEEQVSELVSTADPDGYEDNDQSRRLKGKSTAGVKVLGMVTLNDLDKLAFEGKSGRGWIACTTDSIFLDKPSYYDLLIDLRNATPNTRPAFYIPKPVEHPSGRGVAYRLSTVRFTWSDVRLWTELDRVLQLDSEDSVGSCCDPSHHSGKPRNSTSSSWTDVWRVYEDVCVMCAGLWMGAWRSTTASSSEPDTPRRSENWGTSTTLGAGSIRLDGDDELNVRMVGLGIEGRPAGSGSTLTSSKPSRATRRTSTTSVWTWAGIKGANANANAGDAQPVATTTTGEALAPSEGMFIPGERSKLPEPAGPEDAVASARRNRQVLTTLALLQTFHANTTAILSRLGTLLETRKPCNVAASSSRRLGLSSSAGVVGEGGGDGAGTVVLTPKDVMSFELGPFSALDARFVEWLGEEYGGGVRVLVKRGWKDLVGLILGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFG3</accession>
    <name>A0A2G8SFG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_05184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFG3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFG3"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL32481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="544" mass="60550" checksum="3A772DEF181BA475" modified="2018-01-31" version="1">MFGRGTLGYVAYDCKTCGFVWLKDAWRASYMLAETEGDVLRKLNDSRVQYVPTLVCDGDVRDQTTVTADWWEQMHPDPSTSVRPPPSLASSSSSATLASSASPGSRKRKRGDATSTCTSRRSRWSPGVTMHSDCPLRRHKHYRLVVEEVCMPLKSFQYGRQLVSVVLDCLRAHYQAAIYPKTRLLHCDISDGNILICPKIRRDKNGENPMVVWTGILSDWELSKPVDTQDTASRATQADRMGTYEFMSVNLLNRIAQPVKISDELESFFHVLVYYAVRHLRSNCTGVASWIDNYFHRYAGPERMLTCGQKSYAIEVTGRLQIRSPDRPLVFDSPLDDVLATILESLHAHYKVAQYDLAKAPPSPSSSPPPPLRPETTPPSPPALPILVRELDFDDVDDAQLAQWEAELEAGPRDDSPTAEDRALARNVAGHRFVLDLLLRTLRDPRWCADDRIPIPRVADPNPDTGCGASPTADLNLKPGAGSEEDAELANEQGPPSKSSKRQRTSGPDSKRNASLPVPGPARLRASARRSRTNARTLPIRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SFK5</accession>
    <name>A0A2G8SFK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">GSI_05224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000010">
        <property type="protein sequence ID" value="PIL32521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SFK5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SFK5"/>
    <dbReference type="OrthoDB" id="2724649at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PIL32521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="552" mass="61243" checksum="5DF59807F0FACB66" modified="2018-01-31" version="1">MDAKLPIIAALVVHQFLRRYETFFFSFYSLALLVPPALIVSLPSHNGYGTAPTPSSFLQCLALYLATLATSIAAYRLSPFHPLARYPGPLLGKLSGFWMAYVSTGGRQQHYLKALHDRYGDVLRIGPNTVVIRKPSTANTLTAGGGLPKGPQQLGRFLSDRNLAMIALQDTELHLRRRRAWNRGLSPAALKGYEDQIAKRSSQLVNKIEKHKGEVLLDHWFGYFTYDVMSDMAFGGGTGDMLSGKGDTSFWTGLEKSARNATFLGHVPWFGVLLGRIPFLMSGNKDFNGKCKDNAARRLQRGSVTRDLFHYLNHEDVQDSKHPRPPFQQLVSDGILAMVAGSDTVASTLTSLFACLFAHPEVYEKLQEEVDKYYPPGEALHTKHHREMHYLTGVINETMRIFPAVPDCTQRQVPKTGDGITVDGVYLPPGTAVWMNAYSMQTDARNFSPSPEAFLPERWLPASDGRALCHGPGGYVHNEAAFMPFSLGPMNCIGKALALQEMRTVVCAVLQRVRLRPVGGWRLEDYDRGFKDYGVTVRGELPALVEVRAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SGZ5</accession>
    <name>A0A2G8SGZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BD-FAE-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SGZ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SGZ5"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BD-FAE-like" evidence="2">
        <location>
            <begin position="52"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="318" mass="34525" checksum="3D04165A636C3A51" modified="2018-01-31" version="1">MDYVAGTKDMPIMSIVESTKLAFMKLLENRRSDIEGHPQKTFKFGETDRHQLDVYYPDPAAVSADRTVPVLFFIYGGGFVAGDRKYKAPLDLGYANLGTFFAKRGILTVIPDYRLFPNVVYPAPVEDVRDAIAWLLANAHTVASSPASTIPASSPLSSVFVLGHSAGANHIASLYLSPTLLPLDSPVRAATRGLVPQGGPYVFDFAAPEGSLPPGIVDVYYGSQAQAQARMPLALLKAGSEELVRGLPEFFVLKSAMEPALVDKGNDAFVQALEGRTGRKVKYEVMRGHNHFSPHWALMSGEGEEWGEDVAAWINAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SHU6</accession>
    <name>A0A2G8SHU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_04784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000008">
        <property type="protein sequence ID" value="PIL33333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SHU6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SHU6"/>
    <dbReference type="OrthoDB" id="2758439at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL33333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1129" mass="121943" checksum="0561114D98A287BC" modified="2018-01-31" version="1">MLIVGSRSQTLDHEHGQLKSIFLARIPSLTYGEPPPDQTDTQSAKKGPGLEKAKATASAPKKLLNPSTAMTHFPTLPPPLPPPRQASEAVAQGSVPSQDRNAPSPDTVLSGHATGDAHRSSHGGAVVDSSGYSHGASDESIGATSGLDVNIPAQLPPLPFNTRLPTIPEELGTSTCASEPEVQLPNVVMLSNNQTPPFPDLPGNIRSDSHPENDTLVPSNGNLTSKRIDVRSNDRTTNRLANRPGDGSSNPLIDRLSSSANNRIASQSVPHSQGAVDFSSHADPNVRGIASTAVVTSGENPFHETYGLKTANGMYTITDPLSNPAPCAQPEDMAMDDGDESPADSDLDVTDDEGGEGEEENALGRISDANRLVLKAELHEVHKRLRKVAKKTGLSTSQVFNHWTLATQRKSSKSNAWNLYGKYFKAHEKQELAHLREPIPSDAADVNIRQLCYKAFMADVHPAGPNILKTYSMAEALKGGSMSQSYVERKAEFHRVKDRLTDIMKQSESLHGFSGVFAIVGNVPNSDSGLGVVYETNHAKEFFLTRCRADKDAVLTHLKAHVYNNSSHTLVDLTFDEPLMTARARRGVADIQAAKATGVTHVLAKSGGQADSVAGPSKRAAEEVDQRSSLDSDEEPDDQRRLGISIASKLLHQLNGLAIPNAGVWKNIPWKTFGKKAVQHKFIARNWPEGVPLPPIHEIGQRRTQLQGSDEGEAKKRIVRSIQALPHGQLRLLWSAIYDEKNPLHFARYGGRSSELGKSLDPIVWGAPPRHTSKDRFGRRLFADGRVDRNGVPRLRPPSDNVEKGTESASDSDHSLPEDSAVHKKSSYRRKPISIPSLPTKKTPNAAASEYIDICDESDSDSDSDSDPPAPPKRKSDPAPRSTSRSKLESQRPQKAGTKRKRESLKDSQPSTKGKGKEKAHSPEGKDFLHGSSMVGESKRPRLHPPGYQDPSAVSRPDNFSNTPPCAYTGARPDGFSNFGATGGSNVQPDGFSTVGAAGRSNVQPNGLPDIRPDNFSRVEAIGHLNVRRDGFSDAQQDGFANIRPDGFPNVRPDGFANVRPDGFANVRPDGFANVRPDGFTNVRPDGFLGVRQDGFLDVQANGFPTVRPDSWPDTGMGPRSDVGAGYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIS1</accession>
    <name>A0A2G8SIS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIS1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIS1"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="202" mass="21340" checksum="0EC1A328962FCA97" modified="2018-01-31" version="1">MSLSTPTPDDLEELLLSARYGDVDDIQQFVDKFGSDALTTARDDNGNSILHMVAGNGHTDALDLILPLVPSSLLAARNNAGSTALHWAALNSHLDVAKKLVQHPGGPGVDLIDIKNSTGRSPLGEAENAGWEEGARWFVEVMNLDENAKGETADAEEEGQSAEGVESVEVEIQDAEGQVARMTLGPSSSGPITRPNALSEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SIY8</accession>
    <name>A0A2G8SIY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_04311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000007">
        <property type="protein sequence ID" value="PIL33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SIY8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SIY8"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF6">
        <property type="entry name" value="L-CARNITINE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="405" mass="43603" checksum="9E12D98D752E8889" modified="2018-01-31" version="1">MCHYGAEVIKVEPPNVGDPLRVWRELDVDGVSPWWRSIARNKKSVTIDMRKEEGRKLVKQLAVKSDVILENFKPGTLEKWKLGPADLHPLNPSLIFTRVSGYGQTGPWASRPGYASVCEAESGFRYINGAPDPETGALSGAPVRPNISLGDSVAGLHAAFGTVLALLSRKNREAQGLQGGGQTVDRVCSMINLMEGIIPEYDRKGKIRGPSGSSVTGIVPTNAYPCAPTPDAPTVPTYVVIGANADSIYNRLMGALGRADLTGPAYAHNQHRVARQAEIEDAIAAWTRTRTPQEVEDTLRAVGVPVGRVLNVKDIVESEHARARGLVEDVWVSKPSGEGESKGEGEEGGWTVKMSKVVPVLEGCDAKTRWAGPELGQHNREVLIGELGLDEAEFARLQAEGVIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SK65</accession>
    <name>A0A2G8SK65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SK65"/>
    <dbReference type="STRING" id="1077348.A0A2G8SK65"/>
    <dbReference type="OrthoDB" id="2802356at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="437" mass="47101" checksum="CFFD078F214219F7" modified="2018-01-31" version="1">MAYNYYQTQVPGWGTTQFQFGAPPVPTFHPQPSWRGYDFYNAHAASPDPGLFESIMGRLRDVLGLGIGHSDARHWHKKVYSGMVPLSQLLPADIGAAAAYEAYRTWKYNSFLYEPLSADRERQREGLIGMAIAETQRLWQYSGRPHDAYGLRAACEAAAAAGSSLADRLFSSYGSNGLGRSSSFSSASDAYAYDDGYNRHGRRSRHNSFNNATVVRVGGGSPSLGHAVPAYAGSAPGAVPMPIPGQPIGAQYAVGTPGSYGTYGTPYAASAQAALPGSYTYGSGLSGRVSPSPYGAPQVAAAAPYTYNGMPVGGGFAPSASPYPGAQPGGYVLPNGQSVPPGSTVVITKSRSRRHSSASRHHKHHSGGDYGDYDYGRDFERERERADRERHERDRIRWEQEEQRQQYGMDEYGRYGRVGGSYDAGMPGAGYGYGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKE3</accession>
    <name>A0A2G8SKE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_03934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000006">
        <property type="protein sequence ID" value="PIL34223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKE3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SKE3"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="210"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="875"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL34223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="105514" checksum="E9967F7B0F49944F" modified="2018-01-31" version="1">MATVAGRKKSMVASLPPAIDSPIANNTLLNKAASQSTSLYQQCSSLRTRLMHLQDFSDWFSLAAQPDSARRSTDPVTQLWDVFALGVPLCYLFNLLPLSASSPIAVETDVLSFDPTNERTKKHAIALFAMNVKQVPGCEGFTVRDLWDRNSTDGFVKVVSNVINLVQQLPEDLFLESAPSSPTIASALASTESLTSDNSLAATAVEPGGARANIIKELVDTERKYVQDLEVMQKYCDEAVSCLDRDTLHLLFPGLNKLLNFQRRFLIKVESIAELPWHDQRWGLPFTENEEEFAVYEPYCANYTMASEIMLQEEHNLTALNHIINVKGELPAFLIKPVQRICKYPLLLESLLKAVNNTDYPWIDELKAGVDSAKRITDKINEAQRRAENDATVKNLEGRVEDWKGHHISNFGALLLDDIFSVTKSEVDREYHVFLFEKIILCCKEYIPQPGNGKKVGKSNSILKKPASPSTTFGLPGAGPSNKKKSTPLLLKGRIFLNNVTQAVPKVSQGQYSLAVWWRGDDDLEFFTLRCRNEEQLKLWENQLNRLIKETANRRSSGRDVSRLAQVANSTSPSPQVRSAHSSYAHDSRSSTFSNGSSGYPSGVPHTASINGRMRHPYASDEHAVPQSSHPYASGYAHGPQGYPPHDGFDVDQDDEYEDYPLASAGSASGRGTPMGHPRRPDYPYPHSARHSGHPVSPTLSGGIGGFQQMPASARPIMSRNTGSHASDASFGVSGPRPALRSQFSSTRLRSAYDGPESRGASPMPTPTHQPMRSRSASQPQAYNPPQQVPPPLPTSNRAEWSQGPLSSSKRGSGSSQSTDSADYSPHTSSSPITPYGSSESSLAGMGVATGRSMRGHMDQLPPQPLKEELRLSPPVKIKVHFHEDIFVIQVPRSTEYSELVDKVGKKIRLCGPRRDDGPLRVKYKDEDGDLVSLGSTEDVQMAFESFRPGNQVTLYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SKI9</accession>
    <name>A0A2G8SKI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SKI9"/>
    <dbReference type="OrthoDB" id="2844016at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013903340" evidence="1">
        <location>
            <begin position="18"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="199" mass="20593" checksum="EA84AB0146E626E8" modified="2018-01-31" version="1">MLAFSLLAVTFAAVASALPAAKRALGPWCDNLGGGAFDNVANFTVAAYNTTGTNTNTTGAPLVLGQAGAIDGASFKVFSTFATFPYNQYPFIELVDGRLIPSGPGTSPTAINGVTAGSEVTFVASNSVDPTKSAQIWCAVADTDPAGHGTGHPYLALHGDTDSFSLCQYLSQNNVVYKAAAGNGYDFDTCYPVKLQLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SL45</accession>
    <name>A0A2G8SL45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_03063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SL45"/>
    <dbReference type="STRING" id="1077348.A0A2G8SL45"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="33"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL34288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="339" mass="36692" checksum="FA0D22CF392669C6" modified="2018-01-31" version="1">MSATLVSKSERAYIQASLQTTPPLRADGRSLLDFRTVLLETGVAPLANGSAKLNIGKLAREGGGGTEVLAAVKLEVEDVESGDGVDGGRVACSVTCSPSAYPHLTSNALDDLQHDLTVILQQTIAHPSLHPSNLAIIPGRRAWLLNLDAVILVDSGNVVDALFMAARAALWDTKVPRTRPVAYQAPSVSKNAVKENQDSMDVDQGTSSLDTRDMGRTAADFELPDYWDEGEVLQGRERWPVSVTLNLLPPIHLLDATLTEEASVPLRLHLMFSFPSSAPPTLQSMRLSGPGELDLVYLKSCIADGEKYARGLFTALESKLREEDVRRNAKARDRFAALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLR7</accession>
    <name>A0A2G8SLR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_03496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLR7"/>
    <dbReference type="OrthoDB" id="2757163at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL34715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="372" mass="39859" checksum="E474C6C25A345C16" modified="2018-01-31" version="1">MFTTTSIYLAFVLYDTLSIERATMSAVGEVNRAVTVLEECMEQKSPCLKPRRLRFLFANSDVIRLAAHDIPLEYCVGTAALTTNIIIGDAIVLGRAYVLYPKNRIIRLALLLLLLGTLSTSIVSTAHSCQSPGLSQEFVLPDAETTGVYNLAGPSAGNLMGSFFEGDIFGIAASVISLATNVISTCLVGYRAWQHRALVRGNGLGSFSDRSRVSRAMALLIESGAFYSAIWIVVVVYQFITRPFFDAGSDLMNDGKDGHHSSIFRTFTAGWEGFTEGGLVVVIAIYPTIIMLLVALNRSECDTIASYRGSGQDATVPGSLVFRGSAHHAQTVDFPGGDGGSVPHAAASVFLSSVVDLETADCSFEKEEGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLZ1</accession>
    <name>A0A2G8SLZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLZ1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLZ1"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL34771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="559" mass="61819" checksum="67066E1240A8DABC" modified="2018-01-31" version="1">MPSSFDVPDWLKDHQDLRARDIKLFQGMKLDGNIFCTARPYGSTIPQFVVKVLDPATEESSINERLQDNPSPPNHGLPSEVISSEPRLLVMPYVDNLGMLVFVDRPTSFIIDIFHQIVEVLLPLLRTDARALTSGRVQGVEYLHQLRIAHLDICFDNVACALPHQAASDARLVEGRVYLIDFHTSRQLSLGPGRQPPIVLPPSQEKKPPGVAMLDPYSFDVYCTGKLMQEILMYTSLEEPDLPWIPRRFAQWLVGNERGCTVTLGRAMVWLRASSAPPASCALFILSVVLSAIPVSLSALSATNTLLTDPPRESNGLTDVVQWDTYSLFVHDQRVFLHSGEFHTFRLPVPDLWLDIFQKMVAAGLNGVRRAPSFSIYIHMGATNPSRRVVDFNDWRALQPIFDAAKLAGIFVTLRPGKFSFAPLPCSLLQINAETTAGGIAHWITSEVAGDTRTNATDWTAAYEPYVSGITEAVVPNQVSQGGPVLFVQIDNEFNQTAPHAAYFAQLEEQYRDGGVVVPLTYNDPGEGDNFINGTGAVDLYGFQDNHPQGLKLDSVQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SLZ4</accession>
    <name>A0A2G8SLZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_03524</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000005">
        <property type="protein sequence ID" value="PIL34743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SLZ4"/>
    <dbReference type="STRING" id="1077348.A0A2G8SLZ4"/>
    <dbReference type="OrthoDB" id="3223825at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL34743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31875" checksum="DDDDD5A1262C7623" modified="2018-01-31" version="1">MMLVDEVVVFRNGTLDVRLPYQLSLSIFISPSTTPHPGPSDSRAWPNQRLQRTRYNMRFASPIRVAPPRPIPGLRLPSPSVLRLPRMKPQYSDRRGCVRGHLRESTDDMLYDEAGMYWTVEDYYIESVVLQHGLKPIGWPPDIPFQNLSNIRGGVSALMHLEYRWESGILRFARMMEDKHLTASLNTEHLAPAPKFQLLAAAMHPACQKAAQAELDAVVGPDRLPEFSDYGRLPYVRAFVKELTRWHVSLPMGVPHMTVEDDECNGYFIPAGTIVNVNLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SM23</accession>
    <name>A0A2G8SM23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL34801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SM23"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL34801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="123" mass="13543" checksum="B03D2C2C7ED5541A" modified="2018-01-31" version="1">MSLQSAPTLDRRSALLYLLREADAIDSTFFNTTTGTEGPPKVLPWTFHGLELTVKKRTLSQANSPSNITYDINLGEMLQGSTKPLLAYVLRPKSDAEANRAAFKRCLEDLSVNKAALMSQQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMN9</accession>
    <name>A0A2G8SMN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMN9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SMN9"/>
    <dbReference type="OrthoDB" id="3265210at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="174" mass="20813" checksum="CD333145229BC689" modified="2018-01-31" version="1">MEAEQRRRQAQQAIADREAAKARAVRIRFLEGLVKEERSRLRRRYSGRYWTVSDAINHFTTAGSAFDSARFTMENPPIFDKVPWPTLLPPWELKEEQVNWEQVESFFKKAYARMPTQDYKELVEKAHKRFHPDRWRARQFWKTIGDQEWVEKLDTVANKVSQAVSPIWIESRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SMY2</accession>
    <name>A0A2G8SMY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SMY2"/>
    <dbReference type="OrthoDB" id="2752442at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="178" mass="18391" checksum="C08AB3B916F9A2C2" modified="2018-01-31" version="1">MSHFDPSASVSSLASNATEGTATPDASTANLLPPTQDSRSNAASSPTSAPTSTPSHATISRRHPTTTPKSQTYPSSSTAPPKDYEQAFASLSSAWGFGASVPAKNPKSAKNRGDKKDKKDKKDKQRKKDKQSASSEGTSGARSPAPLMSSESSSRQRSGTPTQSSATSTSTQSQTRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SN01</accession>
    <name>A0A2G8SN01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3 12">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_02891</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11 12">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3 12"/>
    <dbReference type="EMBL" id="AYKW01000004">
        <property type="protein sequence ID" value="PIL35103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SN01"/>
    <dbReference type="STRING" id="1077348.A0A2G8SN01"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03806">
        <property type="entry name" value="GT4_ALG11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013634502" description="GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="47"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="14">
        <location>
            <begin position="299"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL35103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="505" mass="56429" checksum="B6F5C49860CEBF5E" modified="2018-01-31" version="1">MFLALVGFLLALLVAQTTGQIFGLRRRNLKQREKLFSELGVEDASKKKIVGFFHPYCNAGGGGERVLWAAISATQGKEPDIISVVYSGDTDTTKEKIIDKVKARFDIVLSPKSLHFVFLESRHLVEDSTWPRFTLLGQSLGSMYLVWEAMSILIPDLFIDTMGYAFTFPVVSLLGNIPIGAYVHYPTISTTMVSRVKSRAAGHTNSATISSSNVLSTGKLLYYRIFMYYYAYSLRQARFIMVNSSWTKGHVDSILQYSDKFLDTIHLLPPLVLLEVLSRRRSECLKEAQIVYPSCDTRQMAALPLEGRERVILSIAQFRPEKDHQAQLRAFHALLEKYPEYRGSGPDAVQLVLVGGSRNVGDATRVENLRLLARELDIQEQVRFVVNASFPDMLGWLARASIGLGTMVDEHFGINIVEFMAAGAIVVAHASGGPLLDIVVPLDGEPTGYHATSSGTFAEAFRTVLTLSPEADIAMRTRARTWAVRKFSAEEFERGWDESGWRKWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SNX5</accession>
    <name>A0A2G8SNX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_02188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SNX5"/>
    <dbReference type="STRING" id="1077348.A0A2G8SNX5"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL35461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15489" checksum="F15C18C71ADF28C5" modified="2018-01-31" version="1">MGNVTSLVIAGYSYGSLIASLHPVLEDVKTSHILLSYPMGPRHWLTAFHGHRYMTALRTLVDDPRSNVLVVYGDDDNFTAVQSYDSWVASLRENPADRPDASSSTQGKLDVVKVAGASHFWREEDAVETLVETVREWLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP67</accession>
    <name>A0A2G8SP67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_02278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP67"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP67"/>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="3">
        <location>
            <begin position="41"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL35550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="412" mass="43921" checksum="8B6AB92738D76482" modified="2018-01-31" version="1">MPAAAKHFAVPKPGVPRPALPLEHVNPHLRSIDASKPPAVKFQEIVRDGQATIVGRVKIPTPGGHAFILRRLDTGAISVTTMFRAAFPTANEEAEKAETTWIKLSFDTSGANKSGKARFAGTWVTPDVALYLADSYALDTIIPSLANAVPDPNTTFRRSKGQQPTPTASPAAEPGPAPAKRRREASPASPIPAKAQPPAPAPAPVETPTSPQSSHRGGSPAPRRSARLRSPGATAVPQTQPLVPPTPTKTPRARRAAREEHSTPAGSDETAVDEDSEAAKVAEPNMQDDIQEQKELIAKLKAERAAAKAKAIAEAEAEGEQETEEAPTPSQQEAEDAAVGEKRPREEAPTGYRFNFKEPGQEEVGERATVTNRRVRLLSQMPPERKSLAWGTLAFAIGLGAVTFLPNLQAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SP68</accession>
    <name>A0A2G8SP68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_02283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SP68"/>
    <dbReference type="STRING" id="1077348.A0A2G8SP68"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL35555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="254" mass="27062" checksum="9816F47267FC43EE" modified="2018-01-31" version="1">MGHNRRRSRSSSSSSSSSDEEKKKKKDKHDKHGRGHSAFPTPGHDFPHAAGVAHASPGPSFASPPSFPQVAGGHMPQVAMPLFPVTDHGAEHGFPPSRDVESHTGAAPPPYTSAPGAPPASGFRIPLSDNMQFPSQQAGPPVVVDADGRTPVFIGSALFERAVHPCKIIPTFQPPARVAWGGREHEHRGRYDLLPFDPNTMEWVPASHGQLPPGRRPVEGGYEENGEKLYHALASVQGVRVPGKTGAHLVSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQ28</accession>
    <name>A0A2G8SQ28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_02408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000003">
        <property type="protein sequence ID" value="PIL35678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQ28"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQ28"/>
    <dbReference type="OrthoDB" id="2507450at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013856380" description="Transporter" evidence="2">
        <location>
            <begin position="25"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL35678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="76719" checksum="AA37EDC89B1E98E7" modified="2018-01-31" version="1">MAFSKSQAVLVALSVLASTQGAFARMKWLERDNRPVLLNPRRFGQEHPAVIDKLGAACPGQVCGVLSGQAITPLLAAQPECSQQDMADAIIDAAQQFDDTTKANMIALAVEYRQVEKNTPPDFTTNPPTNRNSVFCQKAPKNSQLNGLVQAQDPANDPNIFFDPATQKSVTKGSQANTFPFGTSGSDDSDATSTASQVLVATSTSAAASASASSDCDTVVTVTVTATAAATDAASTSASASQPSASAAASGNIGDFGSCTVPQITFAAGLDGRKETAFEPTDLTSYNHGSAQGIDIITQFICDTLTNSCGADATAKATCQTAKAAADTGAAKTGEQADLFNAAFGITTNFADVVAIDDQGNAIPGTGSVDNQNAITNGTGGIGDFGSCTVPQITFAVGLDNRKETAFEPTDLTSYNHGSAQNIDIITQFICDTLTNSCGADATAKATCQRARTAADTGAAKTGVQADLFNAVFGITTNFASVAAVDDQGNVIAGSTGSATAAAAASTNNAAAATSTTAAAAATTTAAASGSSSGIGDFGSCSVPQITFAVGLDNRKETAFEPTDLKSYNHGSAQNIDIITQFICDTLTNSCGADATAKATCQTARAAADTGAAKTGVQADLFNAVFGITTNFASVAVVDDTGKTIAAGSSGAVATTTAAAAATTTAAAATTTSAAAAATSTAAAATGQNLQTFTGALGGVTAPAVTATSDGQFQVDGNSAFKDLSNALTRSCDVQHNKCANAANASGNQGDLTVAACGDQQTQCDAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SQF2</accession>
    <name>A0A2G8SQF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber evidence="6">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">GSI_01657</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="6"/>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL35997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SQF2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SQF2"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="24">
        <location>
            <begin position="393"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="160"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="744"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="23">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PIL35997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="765" mass="84270" checksum="DF46824EFC2258EA" modified="2018-01-31" version="1">MYYPQQSPGIAHKLPTHQHPAQVQDQSAWARHPAFGPATNSHPPTSPAYPLFAHNGTMTAMQHHPHQHMPGPLAHHHHQNSLSHPHFSSPPNGNAMQGPHGGLGQGGSPGTIATQMMTAHWQQQLLKCEMIRASRSPHHRARASAMAARTVQKAAIPITNPNAIKPPETNGVVKDRDAASNASPTTKFQAASDMSPTTASALANHPSATVPPVVEASRPTAPKPGNTWQSLDMGGVGIKNIPPTSGLFAFTFLTNLYLNHNALTAVPPQIAKLRHLELLDLSGNGLMTIPVELGMLTSLKELYLFDNHLQTLPPELGTLHQLQTLGIEGNPLEPALKQIVQKDGTPALISYLRDSCPIPASPPDRVWKHFVSQAERDAMKTDPTVETFSVVCYNILCERCATERLYGYTPSWALQWEYRKELIIKEISQHNADFLCLQEVDNAQYEEFFSKMLADQGYEGAHWAKSRYKMMSENERRMVDGSAIFYKASKYSLVEKHLIEYSTVAMQRPDFKKTDDMFNRVLGKDHIAVVCLLENKETGTRIIVANTHLHWDPAFSDVKLVQTALLIEEVEKIAQNFAKYPPRLPPTPSSTASSGTTPSTGENNGSARPPPVYSDGYKIPIIVCGDLNSIPQSGVYEFLSTGTLPPDHVDFLSHTYGKYTTDGLRHRLGLKSAYAGIGELSMTNYTPTFKGALDYIWYTTSNLSVDAVLGDVDQSYLDKAVGFPNAHFPSDHLCIVADFRVRPPREAQPPRPPPVFPESSSRAHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SR25</accession>
    <name>A0A2G8SR25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000002">
        <property type="protein sequence ID" value="PIL36219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SR25"/>
    <dbReference type="STRING" id="1077348.A0A2G8SR25"/>
    <dbReference type="OrthoDB" id="2796738at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="172" mass="19184" checksum="5AFAF6E0867EC23A" modified="2018-01-31" version="1">MSTEKHEPDVDVKDRDRDSTSQAGDASQFDFASYYDHNAGRLVVDPDTEHQSTYSEAKREFGDAVASRLKLSADGSKVLWPQPLDDPEDPQNWSDFRKNFQLLIITLAAITPDFDSGIGIADIFALANQFNTTTGHINNLTSKNQTPQAASQLEHLPARYLYHSFLIGVEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2022-12-14" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRJ1</accession>
    <name>A0A2G8SRJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRJ1"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="118" mass="12500" checksum="525E40D256989C7E" modified="2018-01-31" version="1">MAPASTTSSHRLHTAHLIALNRWLRESNLPAYAMLQEVPTRVSAGGLYLVTGIRGGSPPGSARPLYSKECVGIRARNDFASPACPRTLPAAPQGSLARGHPPPATPQLLGTGKWQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRP6</accession>
    <name>A0A2G8SRP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRP6"/>
    <dbReference type="OrthoDB" id="2762075at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="228" mass="24949" checksum="EAC46545B09D3623" modified="2018-01-31" version="1">MSCTTSSALRKSGATTILRPGAEARTPFDTPFFNLVIDPETDTGTFVKQRLDTRMWEEIRAWEKLQRTGKLLENIEYAAVLQEIRFAGDDDDLAVEAPTSEWAVGGGYFVPDVDGPGDSEETTDSTDGDGNNEDYDDRLWPDTYSIASDLDIDYILDGFVVIDMSDATGSVFWNQPRRCRRKVSCAGQKVSEPLVAVPSAPSSCERQNALEGGLGDASGGMATYHELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRS4</accession>
    <name>A0A2G8SRS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_00131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRS4"/>
    <dbReference type="OrthoDB" id="2757940at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL36442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="350" mass="40018" checksum="21CFF6793256EB2D" modified="2018-01-31" version="1">MGEQKQFQEEIEPEAALLPHHFPPLRHHPTAAISNEHRLSYAQAIFTVHQPPLGQVAQEVDKRDVHRDQIPDFVRMIFTYTQSDATPATIRRLIDLWEIKGLNVAERWDSVTARLQALVGIDKHIEQLWMQARAAFAHNEQWTVVYALLIIGPYFSQVVWQRPPDGQAQKVSLSAHFRYALSLALKEQFDGCETQPSWFDPPRVKPDPIVHVDTDPDDDPVAYIRNALVNRSVEKLQGKKKAQFVQTESSVNEDSQDDVSVEYELSPESKRIYRRLGANPLSSPLPTHRSRRPGLGAANRRRISQIPVDNDHVGDLEIAGELREIGFRRDAEEEDERDDYADDEETGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SRX1</accession>
    <name>A0A2G8SRX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SRX1"/>
    <dbReference type="STRING" id="1077348.A0A2G8SRX1"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="342" mass="35952" checksum="F35F81624F2DE119" modified="2018-01-31" version="1">MPLEATIIIVDNSEYMRNGDYPPDRFRAQSDAVTTLFQTKVDSNPENTVGFMTMAGKGPEVLVTNTKEVGSILGAIHEAQDMLGGAANIPNAIEKALLALKHRSNKNLRQRVVVFVGSPLEDHAADEKFMIKLAKRLKKNNVAVDFIAFGDGIEEGERSILKTFVDNVTSNDNCHYLAIPPGAHLLSDMILSSPILAGDRGIPEEAMGDAGAPGAGASAFEFGVDPSLDPELAMALRMSMEEEQARQAAAAQAAAQASGGPSTSAPSASAPQTSAPAASAAQPAAASTAVAADEDEEDEDAMLARALAMSQGQDVEMAEEESEEDEIKRAIESGAKGNNQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSD3</accession>
    <name>A0A2G8SSD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_00380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSD3"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSD3"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="239"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="403"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PIL36691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="635" mass="70679" checksum="C2075D162DE448A1" modified="2018-01-31" version="1">MPQVEPPQATSSHMMKTTKRGRPFLKDTLDLFATLIVSLELTTNRQYFRSFPNSFTTDDAARNLASLKFSQSNRGPDPREPSRIVTTTTTTTFSMTRDMAKAMCQQFMDARLIENAADPGSNLFKERGVYVLTPKGLHVLERFMSKNGINGDHLARVFSSQPICMKLLHLERRSVDDEIIVSHSAITALFRRFVGRSPNAAPEFMENMDAFQKYHERSKGVALMDVSEKALGKSPSSHKHCFAAVTALEWLCDFTSVIGREEAAEMCAQFVRFGLITLVSDKRKNNDSAIIFTVRGAAGGANSSISQHGEFRCTAKAIYRVTDEGRRLARWDSPEGARPSPNNSTANVSSAARTSEDHSVEASTTEGPVSNDAKIHRRISMTEKLNASYDPDKKAHKESNTDRLKFIMEEPQLRALFRDFLRSNFCEENLSFYLDVQDFKKSFTTTSSAIAAGAPAARGGKNTPGQVAMEKHHEALIQKAFIIYNTYLAPSSQSELNIDHGLRNELSGYLSDVIQSLTGKTFQGRVELEQANAFNATQLQTMIRLYERIQTHVFRLMASDSVPKFIKTQKFLALKIKLVEEDDGPLADFPLMNTSSSTPTVPPGLDAGTEEEVGGAYVTISQRAAIQERVPNEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSK4</accession>
    <name>A0A2G8SSK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dicer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8SSK4"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RNase III" evidence="7">
        <location>
            <begin position="934"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="7">
        <location>
            <begin position="1182"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1385"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL36734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1428" mass="158273" checksum="A824BA1F7A8C6966" modified="2018-01-31" version="1">MNVVAGPPPKKRKTTSPLLSGTNGLPRPMITSEDIFAQLEQGNGDYLTFLRAGFVDLVVLSVIAVVENHEEKMSLLQQALGQCTVAQQSMSANGPRSHRVVLFIVDDNQSIGQYSKELEELDFSVGSYTVSMHSSGVNRWPDVIYNDIVVVAANMLLDSLSDGSLKLSQAHLLVVSDAQRVVPMVTPHPVLRMMTDFYGKTPEIPKLLALLTSSSDRWASLDLAWLEIPWRAQSFFLATKTADSWVGPIELVMEFDSSAPAPSEPSMSAVVRKADPEGLLVRPRHYRRARRVFAQLGSFAANAWWRDTLEKLLAAPTSSEGKAALVQAGLGIVKDHGAMDKLQITLNSPVSNVTPKFSKLLQVLQPCSSYGDHFRGILFVQDRVVAQALPGLLQATESQLPFIRAFAPNCKVKSGSDSSLGSRSFDLFDDQLSYAYSHLHSRGQHSHIVHMVERGNNEQRRILIRLQNVDSELRAWMVSLAHGSHDAPPKSIHVGLNSYQSDSEGEDEDHVVDAVTSARLDRSTAVPALYRFAVQIHALPGAEDEKVSLSLETEEREGAPAFRYIVSFPRCTMLQIFTGGFCSTPWEARRDACYQACKKLIRVGIMDHRCFPQSQRFPQDHSSSVGTNSVASQDVKTANTSATTHGYPRKFPDFWKNTQSEPATTLYPTVVAPDNMGGDVHSPILLLARAPIPHIPEFTLFFSGLRTTIRFFQAAPIEVTEPRLKALHEYTLRVARSLTNKPLECPPESLLCYFAPLDSSWHSNLSAHWPLLSVEEHILWDAVQLAADYFAIGLLDGNVSVDDRANDAIVLDRQVEFTMRYYVVKVRHDLTPLSKADDSPREDGYDNFLEYCKARCKEFQGLEDVNQPMIEVNVVPGIVNNLHPTSAPPTPPAKLPLKYLIPELCQKFTIPASTFRTLWLIPSIMTKLESYLLVKELNARLFENTVLEQQLLTALSTPAAYTEINYERLEFLGDSFLKVVASNFYYATMPASGAGDLHHARKSLIANRVLPEGATHAGVPSYIQHKRFVAKLWHPPMATANRVAQQVKCKDVDGNAEMKTDPTEKKDKGKRSKKQRQLDEQNTIWMGEKVSAHHRNEKVIADVVEAILAAAFLSGGHEVALQAARKVRLPIPNIAQWSDYARLAAERAAQAQPATMRALPPSTSVEAIEIILGSKFNRPELLGQALSAMVSNETLAAFCVHVGLQQYIHMESKELTAAIQKYMDFLGELRKKEYDFAERENRLPGQYWLDMPMEPPKCLSDVVESLIGALYVSDNFFEMGVGHFFETVFKPFLEAHVRLQTLSANPKITLLELLQAEGCQNNAVVKRPQTRQNMPVEMDVFIHGKIIASAIDSSAVIATRKVSLAALDTLTHDPELLARMCDCRSSTSSSTKGQGAKVPVAKGDTSLEEETEVAEIEAAMEAHGGSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSK6</accession>
    <name>A0A2G8SSK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">GSI_00401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSK6"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSK6"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PIL36712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="504" mass="55303" checksum="6144BC98D61D4E14" modified="2018-01-31" version="1">MFAGLWARGFALECRSATALAHLSRHGSSRLLHQTLPKPTSLPSLARNRVPAWSTLSAFRKNGLWSPSRHLALRAGGSAPRRAFDPRFFSSNAAEIPASELPVLSPPAVGGWLVASAVLVFAVIVVGGVTRLTESGLSITEWRPIAGVLPPLTRAEWEEEFNKYKATPEFKLLNHSISLSEFKDIFYMEWGHRVLGRLIGVGFVVPLAYFALRKRLTATLPRHLFGMALLIGAQGALGWYMVKSGLEDSLMETPGAVPRVSQYRLAAHLGTAFVLYAGMFYTGLATIADWRYANKGWWSGLKENGSQWKEILANPHIKKFARNVKGLTALVFLTALSGAFVAGLDAGLLYNEFPLMGGRLAPPADELFDPAYAKNVDRSDLWWRNILENPTTVQFNHRCLAITTYVATTALYLSARNPVLRAALPPLTRRMATGAFAMANVQVALGICTLLYLVPISLAAMHQAGSVMLLTTMMHLLLSLRRPGAAAQAWRQAFRNAQKAATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SSR9</accession>
    <name>A0A2G8SSR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">5-aminolevulinate synthase, mitochondrial</fullName>
            <ecNumber evidence="5">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">GSI_00521</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="5"/>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SSR9"/>
    <dbReference type="STRING" id="1077348.A0A2G8SSR9"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="15">
        <location>
            <begin position="208"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PIL36831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="678" mass="72610" checksum="753C8241BCBEA29E" modified="2018-01-31" version="1">MDKLSNITKFKAVCPYLGRTKSSTIRTLCTAASPRYPTLSKLTEKATQCPVMGQALTIRSNQMVAGYASLAGSAEFNKIPEHHGIKPSAADASKCPHASKAIAAARMAEELASAKKGKAPRLPAAAAAAKAATPAPTGCPFHAATNAGSTSEPKPKATTVGGFNYEKFYTDELEKKHQDASYRYFNNINRKADKFPIAHTGDPKDEVEVWCANDYLGMGNNPVVLETMHRTLKAYGHGAGGTRNIAGNTGMHLALEAELAALHRKPAALVFSSCYVANDATLTTLGSKLPGCIYFSDNMNHASMIQGMRHSGAKRVIFKHNDLEDLEMKLAQYPKETPKIVAFESVYSMCGSVGPIAEICDLAERYGALTFLDEVHAVGLYGPRGAGVAEHLDYEVHKQAGQSPDPIPGTVMDRIDIITGTLGKAYGAVGGYIAGSTDFVDMIRSYASGFIFTTSLPPVNMAGARASISYQMEYNGDRQLKQLNVRDLKSRFEALDIPVVPGPSHIVPVLIGDATLTKLASDTLLEKYNVYVQAINYPTVARGEERLRFTCTPGHNKDQIARLAHAVDQVFTELGCKRTSDWRKEGGRAGVGLADAQPVKPIWSDEQLGLLDGTAPHVLRPGQKGVVDVRAVTVTRGKFDDLLGPYTSSPVEAISTLVAAPPLASSLPNKAQSVSATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8ST11</accession>
    <name>A0A2G8ST11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_00397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL36708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8ST11"/>
    <dbReference type="OrthoDB" id="2260578at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL36708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="120" mass="12368" checksum="5D7B41DE11271AC1" modified="2018-01-31" version="1">MAFPSGYGQQAAYGQGAAGGQGGDMFANQGYAAQQGFAGGASYDAYGNAVSATDTRYAYQAAQMAAMAGAGEDQSAAYMGQFPQQQAQMFFDPTSGQMIPAEWAENPNAAFQGQSYSGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STI4</accession>
    <name>A0A2G8STI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_00781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STI4"/>
    <dbReference type="STRING" id="1077348.A0A2G8STI4"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="45"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="643" mass="71079" checksum="6327DCD6311CE4DD" modified="2018-01-31" version="1">MSLYAQTASYAQMPYQGQGYGPTVVPPNPYYAPPPPVPQPVFHLDANTFRRDYMTRLANLTVNSRPIIQTLSMIAQDYNRYADVVVQCIEQHLRRVPPWMKLPSFYLLDAISKNVYDPYARSFTPIVVRLFLDTYEAVDQQTRSKMEEMLLTWRTGSPNGRELFGVVSQVAIERHIWGGESTQSTPGGRDGGSSISQAQVLSELEFVLGQKERVLLASPHDELTKHHISILQQLRGMVQAGVPQRDLQAILTQLRALTTPSSSPPPPAPAPASYPAAPSYSQLPPIPAPPIAPQPPYQSQPPYPMAFEQPQQEPVDLTRLLPPVAPVATTSVPSAPIPDISGIFSALVRAGVVSTTGTPTGAGTSSKPEEPSQSADPESQARQAYRKAIMSVKIKLTSSDVSKHRPRIVETLYERLPTQCKQCGSRFSDDTIGKKQFEDHLDMHFRQNRKATQAVGRGHSRSWFVSLEDWISSNSVDVKGKGRADGRTVSSKVVAAEEAAKREAELRAMFVVVPPGDEAKPISCPICKEPLKSEFLEDDEEWVWRNAVKKDDRIYHATCHAEATASKSSLAVRLRNERPSRSRSRTPEKATPPRVHAPLNGDSRKSETPTPSRLAGMKRKAEDDHTVTVKREGDVPQAKRVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STI8</accession>
    <name>A0A2G8STI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_00715</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1077348.A0A2G8STI8"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110085">
        <property type="term" value="C:mitotic actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903479">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="339"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1714" mass="195488" checksum="16C127EA79748741" modified="2018-01-31" version="1">MPAPIIASPLSPNSTGVTVENLDSPTSNGFSTPAPQRIHLPVSTPLQSSSIAALRNLSSYTQTSDVPAYTSPSRLHRSNTLESLHPNSTGSSVSSENSARSMTTPQTTAPNSPESFSAAPRRRPLSLYGDREVTPTPASPERTSRRPLSSLGMARTTSGSPDKRPDSTSVPPSPSSASSTASSSNPMFPTQYRSSYLAKKRGLDNLGTGQSVRRLERIASGDAPDDWLDNSIPTEPALPSPERDRFGRREERLLRTRDWRQGSPERRTLPEPKLEVKPPPQQELVIPSVMNVDDVVGVPRRKRLLRDTIPGNAPLPSSRLTRGLWADVQRHLIQAYEYLCHVGEAKEWIEGCLGEELPYGVVEMEEQLRNGIALARLVRVFQGEAAVRRIYEAPKLDFRHSDNINHFFLFVRHVGLPEGFIFELTDLYEKKNFPKVIYCIHALSHLLARRGLARRIGNLVGQLQFSDDQLQRTQKGLKEAGVPMPNFGNVGRELAKEINEEPEEEPETEDERRDRLLLECEDSIVSLQAAARAFLVRKDQVTQRARMRLAERYVPKVQAIARAALVRKQLREDRQQRRDLTPFIRALQAQARGMLVRRQWKQHLRRVKSVAPYIVKVQAQARGVLVRRKFQKLKAAIRGCKVSVVKLQSVARARIAQRTHTEIAKSFAQPVVLGNIVALQAHARGALLRARHARQDRRLARAESGVVCMQAQIRGVLVRRRVHTQLAKLDDITNIIVRIQAAARTYLARKRLLNLIRSLRKATPALITLQAIARARLARQQHAAMHKALSEVKVVKSVGGFQARARAALARARHQEQQKRLDFVEPDVVGFQAVARGYLVRVEWNAWRDFLRNSHPHATILQALLRGAMQRKKFRAKMQYYRSNLDKIVQIQSLFRAKETREQYRQLTLGTNVTVGTIKNFVHLLDDSEADFQEEIKVERLRQEVVKRIRENQALEHDVSELDVKIALVVQNVKNFEELVKARRRLGADSAAIHAARASVLAAHGDPFASPSTLDRTAKRKLELYQQLFYLLQTDGKYLTSMLTSMAAEDNWEKNRRMIERVVLTLFGYGQASREEYLMLKFFQTAIRQEVATANSVEDIIHGHPTFINVAVHYLRPKQTAYIRDALQGVIREVVKADDLDLETDPTVIYRVRKDREEMRAGAPNNKAKDIPFHQALQDPDTRAEYIRHLQVLQWWTEEFVRAITSSLSKMPYGMRYMARETLSAVKTKFPDAPTEACAACVARLVYYRYINPAIITPETFDIVSTTVDIASRKNLAQISRMLTQITSGSEFSENHLAYLPVNDYVRKTITSITSWLLEVANVPDAETEFHAHEFLDATIQPRPIWISPNEVYSMHRLLSQYLNQLTSTKDDTLRVILTELDGVPNVGSDELNEARDTAIELQLSNRFARVKDPRADEKALWVQAKRAVLAILRVQPAKDLVESLMQPVTDEHEYVWEGILEEMERDMMRHQRRMPSTHGGDGAYRLEDIRSMTFREVKAHAIYFLLELEKQGMITRMDGYQGILNAIAGDVRSKNRRRVQRLHEKESMEDSLKHLADRKKYFEEQIKQYHDYVETAMNTMQRGKGKRRLLPFTQQYFHMRELQKAGKMPQFGSFKYSAQRFYDKGILLSIDNYSPRQFDKLDVVISSNAVGVFTIEIFNHSLGITNRMAAQDIKMEDLLQAQFEDRASLSMFNGIAKFNLNLLLWQINKKFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8STQ5</accession>
    <name>A0A2G8STQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">GSI_00851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8STQ5"/>
    <dbReference type="STRING" id="1077348.A0A2G8STQ5"/>
    <dbReference type="OrthoDB" id="15478at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF66">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE PTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="38"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PIL37159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="620" mass="69108" checksum="A837C603DC40A2ED" modified="2018-01-31" version="1">MDEVEKAIEYIRETPDVSNEEKKRFFKSANTNLGTSALCLSGGASFGYYHFGVVKAFIDQNLLPRVISGTSAGGLVAALICTYTDEELKELLVPELANRITACEEPFKVWFRRFWLTGARFDSAAWARKACFFTRGSMTFREAYLRTGRILNVSVIPAERHSPTKLLNYITAPDTVIWSALLASAAVPGILNPVVLMQKARDGTIIPWNWGSKFKDGSLRVDIPVQALNLYFNVTHPIVSQANPHVHLFFFAPQGSAGKPVAHSKGKGWRGNFLLSAAEQWLKLELTKNFKVWTRISSIDLIVRIWPRTRLMVSFYLASFVPASRVGFEDWIHILSDPDPAELERMMRIGQLVTWPKLHMIENRYRLERQMFLGRQSVRKALQGGSNDRVTARAESMPLGPVPRPPTGTQLPSLAVPPLSTLASTEDPLPMDTDAEALMLNGDGKSSFSPPAPQRRNSRHDPSEPSLGRPQPRRRRSRASFSSFRDADGDYGGATPDPPPHSASDDLDGYPVQHERQNSSQPSQSHGGSILRRLSRTSLRAAFNSLRRPNPPTSTSAHSKRASVDLEQTWSEDSSTDDDDLSILSRRRSNRYPSVLELQTALQRQLSSDEDDGGQVNEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU67</accession>
    <name>A0A2G8SU67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CASTOR ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU67"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="2">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="606" mass="66529" checksum="84D58FE7B3AB70A5" modified="2018-01-31" version="1">MSDTDSVTISLLPVSLSLVHLPRSRLEQFSTHVLRQILQPNPAFLNVTCNEIEVSLFAEHDTLQEFHKAARKDARRIRQRELEARVSSPDSPRRSRRVRDDWEPIEVTSERWKVLQIDSHSDRLDTSGARVHELSAPIAAAGLSILYQSSYMSDFIFVKESRLVEVTSLLGSAGFDLYLSDPTNLTAQVSAFMSPMLSPAIGYNEGSANPFEVHCLNGSGRKSLDADAGMVFTRSRSNTDETSSSSGSRSRGLSLRVSVDDDTHPKHASDAKPCVGLDRHSERSVSHSPTTCDVRVLPPDITCVGLSDDNADSWGLKVVKLVAFPELILGHSGLLGQTERQPRRPRDPSPPLSALPMEHIHVISLNEGDAGSGSDTTTRVSPDSPKKDPLERSGSQSPIFDIEEKTVIDDAPDSVETSSDDDDSEREACPRLPHLQTSRTARAVDLPEHSRSRSSSQSTSSSIDPPSPLVSFFSFTRTPEGSSLAAPASLLATLFPASERHMVMCGQELDVLDSRNASPERWAEEDEGAVEHEDADAVLPEPEGMLKCLQIDLRKFGLEKHGLVNRFSRTLEENGINHMYSSTYKTANLLIDKAHANRAQALLRSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SU89</accession>
    <name>A0A2G8SU89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">GSI_00830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SU89"/>
    <dbReference type="STRING" id="1077348.A0A2G8SU89"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF14">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="3"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PIL37138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="220" mass="24888" checksum="D5FFC1B77B70D31B" modified="2018-01-31" version="1">MQEVRARHTDKEWIAALRAAANPSAHPLKSVSATNGGTKGDTTGTVPEDNGPRYTMYHSLNHSTRGQRHFGVATFVREPSAVAHAREVGWDAEGRVLVLEMHGGWALLNVYGLNGSEFMWRDPLGQAAPKTRNERKREFNRLLMQECIGLQRQGLRVVLVGDFNVSLGERDCRPRLRTEYPHGLARSEFTEGFMPEVGVADVFREKYPDKRAYSWPWNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUA0</accession>
    <name>A0A2G8SUA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUA0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUA0"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="115" mass="12760" checksum="B9F0C1BD6497CE23" modified="2018-01-31" version="1">MGRELTKIVYKPSPEVNEEFIIIVNPAEFKRWKEGEVVDSFEIFWSNQGAQGLLGRPSKQQLENVFGSSKDVDVVTQILNKGREESGKAIRTQNGTNVTKGSFTVDTKGKSLTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUL2</accession>
    <name>A0A2G8SUL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Virilizer N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUL2"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUL2"/>
    <dbReference type="OrthoDB" id="2011702at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1159" mass="128105" checksum="9CF690AE2B1ACC93" modified="2018-01-31" version="1">MVLLQWCTLEPSEQGGLAAIRFSSPVRVQTIRIFPSDTKPFAQSPDTVSRTEPDAFLLDIFFNAHPVTGPNSKEKPKPSNALVPTSIAYAGGQRDFAVNMGAEYATRLMIVKGTFQSVSMAIYGDVVSDAPTTPEAYEPQPLPSITATPLPSALDPASARDPTQLARELLKLIPDSPELELPIRLVFCLKPSNDDWDSPDFPYLYANLEDDSTEFDLERAFKLTSRPVADDISSEILHGFAEKVSRCVNVKDKDPSQTYLVASLLCHAACQTPTMARSLLDAIDLQKVFDPSTLEDETTLLRLLHASSNVDVAKHLNTDWFHEVLASISGNPNNEDVVRTAARQLTTRIRSWSILGDALANTQGDFVAAAALLRDIGTEEQSFGIWLESMITHDEVVASLAENPVLPVSLPRLLSHRNPSTLPSQDEFVAFLRAYLGVACVLAVYSWSDSLPDERCRARTLGILRLWQGVDGYREMVNHLLLLKQMTFRLECMTDGDTDDPPTQAAIDSEHILVSLAKTPRAFLRPNFVKTVLNIGTSNLFITDEERASMRQAAFVVDDGFAGAVDEVLRPLERPSTFSSLRTLRVALAYLQRELDEDEESKLLDDFWEEANCSFITALCDLLAPVVDDIRSHFSLLEVPSRRSQDVMAQLFFIADDILQLLIRLLPPYPLPSRALRILTTNVADMFSCADAADMSYSPFSQPAAAAQEARQSCLDLAQILVLQDSEATCGKPGAQVVLRTLLQHGLNSYGLDPTHHLLQVFFLLDSVVPSRDSPEEQRTLWVQRVLPAMLHELWAFCHALDTENKVHFVRRLVELDQGGIGIGEWLLVEEVKDMSQAVQTLLDDSLSDTQRLIAHAQVALFFRFFADVLQSPCATWVIEGLAASEEAPHILATSFLTLLDLNLAPLHFGEVADSIVSSYEVFDNEMRFALVIALWRSLQAPELTVSLLERRLEQSVKILVTITPSYINPSKLTSEIGRLVLDLAEHPVPVEGDAAQSLVSLMEWTVKTASTITRMGELSVLSFGQYSKFQDRLKATLPADWIERLDAASNVLVFGGGEEVPPPATSLSDTVELPVHDLEDILRQHTPTPSTPPRRALNQDVFGLISVSPPTLLRSPAATGLTKTYLNNDFRQLRQSSARANTSRLPSMHVDVGVAMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUL5</accession>
    <name>A0A2G8SUL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01159</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUL5"/>
    <dbReference type="OrthoDB" id="2748701at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="356" mass="40575" checksum="991418412451011F" modified="2018-01-31" version="1">MVGDASPYDLATVPTELWRDIIELACTDGGATGRSLILTSKFFHTLANDSRLTSVALFSLDHVQCFLAFVRLRPSEWRNPVRHLYLSFLHEPVISANDESCEKWQSRFTRTMNNFMVLVAPYLRTLTLLQSDRKQLPSFRLDCPMLTELAVWGDISAVVVHSCSGASGPHLPALRRFHFISNEYKARTCLLAPSSWLSTTRLTHLRLSDIDNADEREGFTDTLAGAIGVHMPGSGGSDAVSPQGKGILLPHLRCLWIHGSEWYIASCLEEDWDDGWQLLMPKLREVMKEAERERGMRTLIMERSWRKGRIWALRLWDDWLERMEGLHGCWVESEDEERALEGPDTVKPHEGGQIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUR0</accession>
    <name>A0A2G8SUR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_01001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUR0"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUR0"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43317:SF1">
        <property type="entry name" value="THERMOSPERMINE SYNTHASE ACAULIS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL37308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="639" mass="68668" checksum="96CF2A54A2F48275" modified="2018-01-31" version="1">MSSHAPTTTAKSNPFHAALTRVAAIGVLLGLSLVTWAYQHALEPQYGSAPPALHLSKIIWSASILGSFAPAVPLSRATLGLGLLLYALPNSSYWTAAYTARLGDPIWGPVATHLVVLLPVLALGVALVKVLQDAPYSEENATPQSSITLPVCATAITALQGLWPAVAVVNTLPPNQVFLYAGTAAMTCWAMAPFLPDVSAPPPSATKPLVSTSNSQTSPGAKGRGKKGASDKTAPAKSGSNASVSPGTSAGAARIRIALIPLLPYLTRTVLRGPTLLQPLPEPWTHPSYPLRILSSEQSMLSGVVVVGESLESPNVSNGIENMRYLRAGHSLLGGVWVGPKVTAMDPELVLKDEAGNELGDSVYTAFILQEAVLLAEKADNSRPKNALIIGLGTGISATSFMRHGLSTTIVEIDPAVYDAARRFFGLPAPDHVFLQDARGWVHNRSETVQADPPSSSQTTFQPFDIVVHDCFSGGGIPAHLYTQQFWQELKNIVRLDAIVAVNYAGIISSDSAKAIVLTLRSVFPQCRAFYDSMEPSADAFNEFQNWVFFCTPSSDSLKFRAAVSSDFLGSYLRRHVLSSLPEREGDISTLGSDLSAETRERFILKDTANPLGEWQRKDALHHWKIMREVLPEVFWETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUR8</accession>
    <name>A0A2G8SUR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUR8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUR8"/>
    <dbReference type="OrthoDB" id="2758338at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="423" mass="49197" checksum="60DA5713A755F964" modified="2018-01-31" version="1">MILLEACTDGGRTGCSLSLVSKEIRKRSRAVRFYSVSLLTPSLWKLLRFLHEFGKRRDTAIRGQPPHTMPVVRHLCLLVDIPNELCRDSLDVKRAKQDFLHPDYSLQRRFRNYVLDNSRRRRGWRELPQELALEMLRLEWAYYYAAVMLLEQVAGDLYSLCLYQFPHNRDRRGEGPLQPCVKTFPNLRELWLGGRDGRDASLFLRDTSFPVLRRLHMRADFAPDIMHWLSVAPRLDSLRIVAGPRLLTEEKGRQTLRATAAHPHWREKSKQLTILVPVPRLKRDDPFAWAHFGRCAFELRQELAADPTSPLVFVPCYVAQDVDGCVSKVTEGPGRGRPWPFRIRAWDRRQCSKPVAQDELFRRDWLARIDGWCGGVYVEDFWAHFVGDGEDERKRIEKNIGSYSLPLEGPTYVEPLIIRPESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUY6</accession>
    <name>A0A2G8SUY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_01264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUY6"/>
    <dbReference type="OrthoDB" id="2740860at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL37570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="362" mass="40732" checksum="1127F47943DC7A54" modified="2018-01-31" version="1">MGQYWDLEKDLTGGGKLGEFFFTNHSHLYDSLRIPRLPKDLDMWLSRGSAAVQPGPMGKLSTEVLDMVFERHILHTLISRHARAADCRLVCLGWYAYPPDQAPPGMLTAAELEEIATTPDPDEHSCESVEKAIARRCLYLFAGENYAYAHMAYWRLFEPFRKTVDELWHLRRQDPAKMDAFYSALDLRMITKLGGVGSWAPGLEYAEGPRVLCNTSKGEYVREDALVGWDMEYWRVTLAHALLARVCYSPDDSISMCCGEEYKDGLVKGPWAGDRFRIISMDEMPVLKGGKRWRDVTGEVNELLCHLLEGEFPEEYCKKEAAEKEDVEKEACQQKDSEKDGEKVNGGGGIAGGEVGEGSEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SUZ8</accession>
    <name>A0A2G8SUZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">GSI_01237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SUZ8"/>
    <dbReference type="STRING" id="1077348.A0A2G8SUZ8"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PP4R3 EVH1-like" evidence="5">
        <location>
            <begin position="116"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="4">
        <location>
            <begin position="256"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="442"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="886"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="963"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="982"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PIL37543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="1154" mass="125937" checksum="94BD874B57AD24DA" modified="2018-01-31" version="1">MSSADAASDPAQTVTPQAASSPSAEQPPPQPDPSEPHDPPRDADLALSSSELGPRVPSDPAEQPHDAAAPPMGEGAPSMLEPEVLGAVGEPGDAEHGAGGVDDSGQWAEDDSHELKRVKVYELIGSRWVDRGTAFCFGDFNEHEALLIARAEEDFNRVILTTTIRATDVYQRQQETLIVWTEPNGVDYALSFQDPEGCAEVWHFIEEVQRHLNTGEDMALTSSPLIGPEGPETSVTTANIIRSGRLPQPQMGIIGEIDTAIKALARTAVVKERVCEYIQNEEYIKALIDVFHQAEDLESLGDLHALFGCMQTILLLNEHSLYEHILDDDVFMGVVGILEYDPEFPNYKANYRDFLRETSRFHQPIPIRDDMIQRKIHHTYRLQFLKDVVLARAIDDSTFNVLNSSIIFNQIDIITHIQNDQAFLREIAGMFMDDDLLALLGLPTKNGEPPKEPAPGAPKDADKMDVDSTDAKAPNGAAQPNGHAEGSGSSTPSSSSNKALSPEEFNRRREVVFLLQQLCMMGKNVQLPARMALFRSLVDRGIVFAVQWGLSLSEVEEEGRQMIATSGEIMMALLDHDLNGVRGHVLKQLGTMEREKQNGKSVKDKETVLMLMCRVLVRSKDLAVQSLVGEALRLLLELVGADGAEGPNIGLKMLQQRAKDDPGIEKFLDYFYKFCIELLFKPFQEVPEVKDVPDPTFALSREKTNLFLWLCDLLSNFTQQHSFRSHFFVLSSNIAPRVATLLRSKDKHLRLAAFRFFRTCLRLKNGNIFKHLIKHDVFQSILALTTRESKRDNLVSSTCLEFFDFMRRENIKELIHHCMTKHGATIRALAESPVVGPRFKDFISRWEMNIEPPPMERIEKPLGTPSRGWGQGKLLDTAEEDYFNGDDEDDEHLLPIISTPPRGMLTGKRKRPMRPTGIPVRAPPKPAPFNGIPRTPPLGSLLDYGDDGDDMASIENIAPTPGRASPIPGGFISVAFPPSPSPGGGGGGGGTEPPASPRIAHRTVSPSSIKSAINPEDDSDILAELSKGGPTLLPRISGLGDLGIGIGVGAGVGSKRRRGGDDDDDELLERLAKAKRQTPGPQLQADADSSPGPKAAPPSQKGGREGGGGGGEEGQSQPRKLKLKFGAVGAAVASVQPPKSESASSPGTKDGDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SV43</accession>
    <name>A0A2G8SV43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_01324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SV43"/>
    <dbReference type="OrthoDB" id="2803682at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="152"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL37630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="449" mass="48856" checksum="056F9B096B1CB566" modified="2018-01-31" version="1">MAYSGPVILVHAQFPSVRPGVPGHSDPSTWVWVPCLEFPVERVNALQISSKPLKWIRYCIGAVTGTQGHLSRRQDVPEPVDYDQPLPPESVPESTALYYHVSAAEKELMFPTDPHLADPPKTNSVHSRAATTTSSIACLTFHQELRERDTYCVANGENELFCDAVHLVPHCKDDDYIKALTTRRCRGREEDIVPTIDDVRNGILLQADFHKMLRRTLAFMPLPNFALDINDVTVLPGAAGPPASSQSQSQMYIIHLFEPLEPFPIANTALRLPPSSSSPPPSPSSSSSLNANPNAHRWPPTALFDATYGAAVLHTFGTPHLHARASAIWDALYYDPHHGGSARSVAAAQVQRRRGRIRRAVARDRMAGTGHGEAGGPALRELAALVPYLGMGLGELAAYLEERARGDVAAEGEEKARVAERVRRWREGVVAAARAERGSDLSGLVGGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8SVH8</accession>
    <name>A0A2G8SVH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_01436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000001">
        <property type="protein sequence ID" value="PIL37742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8SVH8"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL37742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="70" mass="7819" checksum="463915825B418DF3" modified="2018-01-31" version="1">MLPSRLSCLATLNLAHNWVPKETFVELMQETIEAEVKRLVQWEGAKAKALATGTEPISWRAQHRIAPGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RL78</accession>
    <name>A0A2G8RL78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000069">
        <property type="protein sequence ID" value="PIL22292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RL78"/>
    <dbReference type="OrthoDB" id="2764441at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL22292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="210" mass="23849" checksum="86FB0898A6AF0838" modified="2018-01-31" version="1">MLDTVRARTVPGAELPDDNNNISSVHRQRVHVEWLCDHDINAFRVYTHAAMNTMRVVPLSGIPHALMWGYNNDNPDNLYYGSEPFVFYAPVKVTHIALEDEGNDEQCLILELAPLALQEIVALDFLMAFAHPVTTDFPRVITVATTLSTEDDFIIPDSAFAFNDDNVNWADVKVDDYLVAELSVYRVWSTPHTWVLQYRLQEATRVATNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPD5</accession>
    <name>A0A2G8RPD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_14696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPD5"/>
    <dbReference type="OrthoDB" id="2739065at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL23385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51208" checksum="767413F7D1D5AFA1" modified="2018-01-31" version="1">MRDPTDCAVPPELELIVLNHLLADKPALASCSLVCSRWLPPTRKHLFREITLKPTMRLNPTPFESFLRTLEIAEETNPEWAIGSCIEKLTIDGSVWKGRLTPSPMLTCSLSFLRRLLSKLPQLASLRAKLLLMPNDIVERPYADQAALNNFKLDKLVVVDCTAKGHDPHHLLALISMFSSIDSLSIINWGGYMQHPISEFSLSSLSPPLVRSLAIEWVSPGVAPAIYALFANSPSVTAGHLAHIYLDASKNSELLEFAGFARIAGAAFRQVDLRANSELFSADHLLDDVSLVNCSALRSLMLCMEPTFDDHASFGDRHARNTREVLSAYALFFQLHRAALPMLTTVRFEMKPIVWMLDAFVRVARDTFPEWPSKAITMVSAEEAEMNRALWEFLEDALGSFPALERVEFVLYERGQEALTEEAKDHLRSALEGRLPELWSRGVAHLVFETFVFRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPE7</accession>
    <name>A0A2G8RPE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">GSI_14687</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPE7"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPE7"/>
    <dbReference type="OrthoDB" id="2757290at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PIL23376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="351" mass="38273" checksum="C1B29F35F53FD149" modified="2018-01-31" version="1">MTSIPLPVLQPIPCVPTPWCTLFDNLKRRTQTDPGTAKKKRRSSALTPDRTSQPGLNDAEDNEQVQQLHPCPLCPRVFPLPNSLALHLKWHWGASGLEWKRGINRNGKGVERARREAEERRCRAPATHREQLPYGSEAGVPESANDPSTTDDSIRGVNGTMYPSPVDNPNVVTGDSSFIPQGVPQTSFEIFRMPCYSSSEASASTSEVGGSPAISPFDSRASFSFHRLPSLEELALPQPLAGNTLGARPCNTEFVLQEGLSHPSPGLAADENFQGITSNHTAWSHNWFGCDNLDQSPGIAAEGEQDLDDVLGNPHPFIEVHTHTEVDGQHGTQENREPLSCAKPGELELVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RPI9</accession>
    <name>A0A2G8RPI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_14746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RPI9"/>
    <dbReference type="STRING" id="1077348.A0A2G8RPI9"/>
    <dbReference type="OrthoDB" id="2019666at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="201" mass="21839" checksum="6C24A3500C05DC52" modified="2018-01-31" version="1">MASHLHTRPQFSDPNNTSAEEPLLSHLKPHILFGNEITDEQLVQCASLFSKNYGLWGPHAPNPLKPGARVKMQPKKLRAECLGSGDPKDSVLGLMLKDGEFVGQAFATKWAVGSETIGWITQLVVDANERRKRIATSLLQGLAASSWFTDITMVGVASTHPAACNAVCNMVPGQRISEVNLSYIQENAPKALQSSTVKYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ51</accession>
    <name>A0A2G8RQ51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transposase family Tnp2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">GSI_14953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000068">
        <property type="protein sequence ID" value="PIL23640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ51"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ51"/>
    <dbReference type="OrthoDB" id="2404451at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004242">
        <property type="entry name" value="Transposase_21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02992">
        <property type="entry name" value="Transposase_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PIL23640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="528" mass="59011" checksum="716DE4F38720F11B" modified="2018-01-31" version="1">MEVLPATGSHDAGVQALPPPLPSPSSSSNRIENSTNVPGLDSSATAALHTAATNLQDSVWAGHDAEGGDNGGPELSLEDQEVWERLHAEEQEVAEYEVISVWDELAESFLREGMISAFLANKPIAKEMKYHAKEQAKHAPSVIRDVTDSENYCALLNKHVTIDGKSLAHKYFDDARDVALGLSTDGFAPFKCRTKTAWPLILFNYNLHPDIHTHLNNILGLGVIPGPKKPVDFNSFLWPVVHEFLQLSVGVHAYNALSNAFFALRVYLILIFGDIPAISIVMRMKGHNGVCPCHMCEIQGVRIPESRNPVHYVSLNRARHPHVLSDPEAVRMYDPSHLPLRTHSNFMKQTKEVQFASSESDSECLTKLYGIKGTPVLSALSSLSFPSSFPYDFMHLIWENVIKNLMLLWTGKYKDLDEGSENYQFPSAVWDAIGSATADSGDSLPYIFGPRPPNIATDKVSWTADTWSFWTQYIAPILLRSCFLHDKYYDHFVELVRLINICLGFDITTAQVDDVHSSFIKWVQKYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RQ97</accession>
    <name>A0A2G8RQ97_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">GSI_13428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RQ97"/>
    <dbReference type="STRING" id="1077348.A0A2G8RQ97"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PIL23679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="229" mass="26326" checksum="6506DC76093134A7" modified="2018-01-31" version="1">MLIMDWVSSAVDHGSTIGLLALNALFMLMKDYNLDYPSFYTRLYSFLERDMLHLKHRARFFRLTELFLSSTHLPANLVASFVKRLSRLSLTAPPAAVIMLIPFTYNMLRRHPALMAMIHRTDDDAGVECDGFLVAEPNPTLTNALESSLWELYSHRQHYHASVSTLAKIFEEAFTRPSYAMEDFLDHTYSTLFDTEVKRKIRKAPAIASVLEFSQVPEGDEMRELWTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RRB3</accession>
    <name>A0A2G8RRB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">GSI_13629</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL23878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RRB3"/>
    <dbReference type="STRING" id="1077348.A0A2G8RRB3"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PIL23878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="204" mass="22587" checksum="CC34E731353EC9DA" modified="2018-01-31" version="1">MHTSEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDNDTFTNVKQWLQEIDRYASEGVNKLLVGNKSDLTSKKVVEYSVAKEFADQLGIPFLETSAKNATNVEQAFLTMAKQIKDRMGSTTTATGTGKSTTITPGQTVQQQQGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RS17</accession>
    <name>A0A2G8RS17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">GSI_13880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
                <person name="Chen S."/>
            </authorList>
            <dbReference type="PubMed" id="26046933"/>
            <dbReference type="DOI" id="10.1038/srep11087"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">ZZ0214-1</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AYKW01000067">
        <property type="protein sequence ID" value="PIL24128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A2G8RS17"/>
    <dbReference type="STRING" id="1077348.A0A2G8RS17"/>
    <dbReference type="OrthoDB" id="3006153at2759"/>
    <dbReference type="Proteomes" id="UP000230002">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PIL24128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000230002"/>
        </source>
    </evidence>
    <sequence length="177" mass="19429" checksum="244F0FA8E0D0CE4B" modified="2018-01-31" version="1">MSAASAQGWYARATAHPFPDFTLTKDAFVFAVLLNAPVDPEGFTMALFQPDVAIDAQGRVLQPQPQDFAALAALAQEASRLPDTGSFMNAWRVSHPRTSQKIDRLFAKTSDSGDIRETSVQGWDPEKTQLQNAVGDHQALPPVLQELFGYIQEARTGFVRGEENKELISQVKALVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-01-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A2G8RVB3</accession>
    <name>A0A2G8RVB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">GSI_13345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ganoderma sinense ZZ0214-1</name>
        <dbReference type="NCBI Taxonomy" id="1077348"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Ganoderma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="Sci. Rep." volume="5" first="11087" last="11087">
            <title>Chromosome-level genome map provides insights into diverse defense mechanisms in the medicinal fungus Ganoderma sinense.</title>
            <authorList>
                <person name="Zhu Y."/>
                <person name="Xu J."/>
                <person name="Sun C."/>
                <person name="Zhou S."/>
                <person name="Xu H."/>
                <person name="Nelson D.R."/>
                <person name="Qian J."/>
                <person name="Song J."/>
                <person name="Luo H."/>
                <person name="Xiang L."/>
                <person name="Li Y."/>
                <person name="Xu Z."/>
                <person name="Ji A."/>
                <person name="Wang L."/>
                <person name="Lu S."/>
                <person name="Hayward A."/>
                <person name="Sun W."/>
                <person name="Li X."/>
                <person name="Schwartz D.C."/>
                <person name="Wang Y."/>
 
[file cut: first 33554432 bytes kept]
[document cut: first 30754956 of 33554432 characters kept]
